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Highest Rated TV Series With At Least 5000 Votes
1. The Filthy Frank Show (2011– )
12 min | Short, Comedy, Fantasy
Filthy Frank and his disease ridden friends talk about various topics and take part in multiple life-threatening shenanigans.
Stars: George Miller, Zeeq, Artemis Holdenberry, Bloody Hairy
Votes: 26,082
2. Game of Thrones (2011– )
TV-MA | 56 min | Adventure, Drama, Fantasy
Nine noble families fight for control over the mythical lands of Westeros. Meanwhile, a forgotten race hell-bent on destruction returns after being dormant for thousands of years.
Stars: Emilia Clarke, Peter Dinklage, Kit Harington, Lena Headey
Votes: 1,123,232
3. Breaking Bad (2008–2013)
TV-14 | 49 min | Crime, Drama, Thriller
A high school chemistry teacher diagnosed with inoperable lung cancer turns to manufacturing and selling methamphetamine in order to secure his family's future.
Stars: Bryan Cranston, Aaron Paul, Anna Gunn, Betsy Brandt
Votes: 954,661
4. The Wire (2002–2008)
TV-MA | 59 min | Crime, Drama, Thriller
Baltimore drug scene, seen through the eyes of drug dealers and law enforcement.
Stars: Dominic West, Lance Reddick, Sonja Sohn, Wendell Pierce
Votes: 202,710
5. TVF Pitchers (2015– )
TV-MA | 40 min | Comedy, Drama
A story of trials and tribulations of four young entrepreneurs who quit their day jobs in order to pursue their start up venture.
Stars: Naveen Kasturia, Arunabh Kumar, Jitendra Kumar, Abhay Mahajan
Votes: 35,013
6. Rick and Morty (2013– )
TV-14 | 22 min | Animation, Adventure, Comedy
An animated series that follows the exploits of a super scientist and his not so bright grandson.
Stars: Justin Roiland, Chris Parnell, Spencer Grammer, Sarah Chalke
Votes: 104,843
7. Sherlock (2010– )
TV-14 | 88 min | Crime, Drama, Mystery
A modern update finds the famous sleuth and his doctor partner solving crime in 21st century London.
Stars: Benedict Cumberbatch, Martin Freeman, Una Stubbs, Rupert Graves
Votes: 560,710
8. The Sopranos (1999–2007)
TV-MA | 55 min | Crime, Drama
New Jersey mob boss, Tony Soprano, deals with personal and professional issues in his home and business life, which affects his metal state and ends up seeking professional psychiatric counseling.
Stars: James Gandolfini, Lorraine Bracco, Edie Falco, Michael Imperioli
Votes: 203,613
9. Avatar: The Last Airbender (2005–2008)
TV-Y7 | 23 min | Animation, Action, Adventure
In a war-torn world of elemental magic, a young boy reawakens to undertake a dangerous mystic quest to fulfill his destiny as the Avatar, and bring peace to the world.
Stars: Dee Bradley Baker, Zach Tyler, Mae Whitman, Jack De Sena
Votes: 143,411
10. Leyla ile Mecnun (2011–2013)
TV-PG | 80 min | Adventure, Comedy, Drama
Turkish television comedy series set in Istanbul, Leyla and Mecnun is a surreal and absurd comedy that revolves around the fictional love story between Leyla and Mecnun.
Stars: Ali Atay, Cengiz Bozkurt, Serkan Keskin, Osman Sonant
Votes: 73,124
11. Sarabhai vs Sarabhai (2004–2006)
TV-PG | 30 min | Comedy
The show revolves around the lives of the members of an Uber Wealthy - High Society Gujarati family of Cuffe Parade - South Bombay, whose daughter-in-law is from a middle class Delhi background.
Stars: Satish Shah, Ratna Pathak, Sumeet Raghvan, Rupali Ganguly
Votes: 9,590
12. Westworld (2016– )
TV-MA | 60 min | Drama, Mystery, Sci-Fi
A Western-themed futuristic theme park, populated with artificial intelligence, allows high-paying guests to live out their fantasies with no consequences or retaliation from the android hosts, until now.
Stars: Evan Rachel Wood, Jeffrey Wright, Ed Harris, Thandie Newton
Votes: 150,054
13. True Detective (2014– )
TV-MA | 55 min | Crime, Drama, Mystery
An anthology series in which police investigations unearth the personal and professional secrets of those involved, both within and outside the law.
Stars: Vince Vaughn, Colin Farrell, Rachel McAdams, Taylor Kitsch
Votes: 350,212
14. Firefly (2002–2003)
TV-14 | 44 min | Adventure, Drama, Sci-Fi
Five hundred years in the future, a renegade crew aboard a small spacecraft tries to survive as they travel the unknown parts of the galaxy and evade warring factions as well as authority agents out to get them.
Stars: Nathan Fillion, Gina Torres, Alan Tudyk, Morena Baccarin
Votes: 197,178
15. Last Week Tonight with John Oliver (2014– )
TV-MA | 30 min | Comedy, News, Talk-Show
Former Daily Show host and correspondent John Oliver brings his persona to this new weekly news satire program.
Stars: John Oliver, David Kaye, Noel MacNeal, Paul McGinnis
Votes: 45,102
16. One Punch Man: Wanpanman (2015– )
TV-PG | 24 min | Animation, Action, Comedy
The story of Saitama, a hero who is a hero just for fun & can defeat his enemies with a single punch.
Stars: Max Mittelman, Makoto Furukawa, Kaito Ishikawa, Zach Aguilar
Votes: 40,943
17. Hagane no renkinjutsushi (2009–2010)
TV-14 | 24 min | Animation, Action, Adventure
Two brothers search for a Philosopher's Stone after an attempt to revive their deceased mother goes awry and leaves them in damaged physical forms.
Stars: Kent Williams, Iemasa Kayumi, Vic Mignogna, Romi Pak
Votes: 57,544
18. Taboo (2017– )
TV-MA | 59 min | Drama
Adventurer James Keziah Delaney builds his own shipping empire in the early 1800s.
Stars: Tom Hardy, David Hayman, Jonathan Pryce, Oona Chaplin
Votes: 29,378
19. Stranger Things (2016– )
TV-14 | 55 min | Drama, Fantasy, Horror
When a young boy disappears, his mother, a police chief, and his friends must confront terrifying forces in order to get him back.
Stars: Winona Ryder, David Harbour, Finn Wolfhard, Millie Bobby Brown
Votes: 269,591
20. House of Cards (2013– )
TV-MA | 51 min | Drama
A Congressman works with his equally conniving wife to exact revenge on the people who betrayed him.
Stars: Kevin Spacey, Michel Gill, Robin Wright, Kate Mara
Votes: 344,303
21. Friends (1994–2004)
TV-14 | 22 min | Comedy, Romance
Follows the personal and professional lives of six 20 to 30-something-year-old friends living in Manhattan.
Stars: Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc
Votes: 515,528
22. Fargo (2014– )
TV-MA | 53 min | Crime, Drama, Thriller
Various chronicles of deception, intrigue and murder in and around frozen Minnesota. Yet all of these tales mysteriously lead back one way or another to Fargo, ND.
Stars: Billy Bob Thornton, Martin Freeman, Allison Tolman, Colin Hanks
Votes: 193,569
23. Arrested Development (2003– )
TV-PG | 22 min | Comedy
Level-headed son Michael Bluth takes over family affairs after his father is imprisoned. But the rest of his spoiled, dysfunctional family are making his job unbearable.
Stars: Jason Bateman, Michael Cera, Portia de Rossi, Will Arnett
Votes: 220,870
24. The Grand Tour (2016– )
TV-MA | 71 min | Comedy, Talk-Show
Follow Jeremy, Richard, and James, as they embark on an adventure across the globe. Driving new and exciting automobiles from manufacturers all over the world.
Stars: Jeremy Clarkson, Richard Hammond, James May, Mike Skinner
Votes: 33,349
25. Skam (2015– )
30 min | Drama
The story of young teenagers and pupils on Hartvig Nissens upper secondary school in Oslo, and their troubles, scandals and everyday life. Each season is told from a different person's point of view.
Stars: Josefine Frida Pettersen, Iman Meskini, Lisa Teige, Tarjei Sandvik Moe
Votes: 10,384
26. The Twilight Zone (1959–1964)
TV-PG | 51 min | Fantasy, Horror, Mystery
Ordinary people find themselves in extraordinarily astounding situations, which they each try to solve in a remarkable manner.
Stars: Rod Serling, Robert McCord, Jay Overholts, Vaughn Taylor
Votes: 47,833
27. Death Note: Desu nôto (2006–2007)
TV-14 | 24 min | Animation, Crime, Drama
An intelligent high school student goes on a secret crusade to eliminate criminals from the world after discovering a notebook capable of killing anyone whose name is written into it.
Stars: Mamoru Miyano, Brad Swaile, Vincent Tong, Ryô Naitô
Votes: 124,731
28. Batman: The Animated Series (1992–1995)
TV-PG | 23 min | Animation, Action, Adventure
The Dark Knight battles crime in Gotham City with occasional help from Robin and Batgirl.
Stars: Kevin Conroy, Loren Lester, Efrem Zimbalist Jr., Bob Hastings
Votes: 57,063
29. Cowboy Bebop (1998–2003)
TV-MA | 24 min | Animation, Action, Adventure
The futuristic misadventures and tragedies of an easygoing bounty hunter and his partners.
Stars: Kôichi Yamadera, Unshô Ishizuka, Megumi Hayashibara, Steve Blum
Votes: 56,513
30. Legion (2017– )
TV-MA | 60 min | Action, Drama, Sci-Fi
Legion, based on the Marvel Comics by Chris Claremont and Bill Sienkiewicz, is the story of David Haller (Dan Stevens), a troubled young man who may be more than human. Diagnosed as ... See full summary »
Stars: Dan Stevens, Jean Smart, Mackenzie Gray, Rachel Keller
Votes: 11,185
31. This Is Us (2016– )
TV-14 | 45 min | Comedy, Drama
Follows a unique ensemble, as their paths cross and their life stories interwine, from sharing the same birthday, to so much more than anyone would expect.
Stars: Milo Ventimiglia, Mandy Moore, Sterling K. Brown, Chrissy Metz
Votes: 22,367
32. Black Mirror (2011– )
TV-MA | 60 min | Drama, Sci-Fi, Thriller
A television anthology series that shows the dark side of life and technology.
Stars: Chris Martin Hill, Hannah John-Kamen, Beatrice Robertson-Jones, Paul Blackwell
Votes: 112,265
33. The Crown (2016– )
TV-MA | 52 min | Drama, History
The early reign of Queen Elizabeth II of the United Kingdom is portrayed.
Stars: Claire Foy, Matt Smith, Vanessa Kirby, Jeremy Northam
Votes: 28,108
34. Narcos (2015– )
TV-MA | 49 min | Biography, Crime, Drama
A chronicled look at the criminal exploits of Colombian drug lord Pablo Escobar.
Stars: Wagner Moura, Boyd Holbrook, Pedro Pascal, Paulina Gaitan
Votes: 171,411
35. Twin Peaks (1990–1991)
TV-MA | 47 min | Crime, Drama, Mystery
An idiosyncratic FBI agent investigates the murder of a young woman in the even more idiosyncratic town of Twin Peaks.
Stars: Kyle MacLachlan, Michael Ontkean, Mädchen Amick, Dana Ashbrook
Votes: 117,826
36. Seinfeld (1989–1998)
TV-PG | 22 min | Comedy
The continuing misadventures of neurotic New York stand-up comedian Jerry Seinfeld and his equally neurotic New York friends.
Stars: Jerry Seinfeld, Julia Louis-Dreyfus, Michael Richards, Jason Alexander
Votes: 183,250
37. Freaks and Geeks (1999–2000)
TV-14 | 44 min | Comedy, Drama
A high school mathlete starts hanging out with a group of burnouts while her younger brother navigates his freshman year.
Stars: Linda Cardellini, John Francis Daley, James Franco, Samm Levine
Votes: 98,995
38. Gravity Falls (2012–2016)
TV-Y7 | 23 min | Animation, Adventure, Comedy
Twin siblings Dipper and Mabel Pines spend the summer at their uncle's tourist trap in the enigmatic town of Gravity Falls.
Stars: Jason Ritter, Kristen Schaal, Alex Hirsch, Linda Cardellini
Votes: 29,221
39. Only Fools and Horses.... (1981–2003)
TV-PG | 95 min | Comedy
Classic comedy following the misadventures of two Wheeler Dealer brothers Del Boy and Rodney Trotter who scrape their living by selling dodgy goods believing that next year they will be millionaires.
Stars: David Jason, Nicholas Lyndhurst, Roger Lloyd Pack, Buster Merryfield
Votes: 33,161
40. Hunter x Hunter (2011– )
TV-14 | 24 min | Animation, Action, Adventure
Gon Freecs a young boy aspires to become a Hunter, an exceptionnal being capable of greatness. With his friends and his potential, he seeks for his father who left him when he was younger.
Stars: Megumi Han, Mariya Ise, Issei Futamata, Daisuke Namikawa
Votes: 20,874
41. Monty Python's Flying Circus (1969–1974)
TV-14 | 30 min | Comedy
The original surreal sketch comedy showcase for the Monty Python troupe.
Stars: Graham Chapman, John Cleese, Terry Gilliam, Eric Idle
Votes: 47,730
42. The Return of Sherlock Holmes (1986–1988)
TV-PG | 60 min | Crime, Drama, Mystery
Sherlock Holmes and Dr Watson solve the mysteries of the devil's foot, Silver Blaze, Wisteria Lodge and the Bruce-Partington Plans.
Stars: Jeremy Brett, Edward Hardwicke, Rosalie Williams, Colin Jeavons
Votes: 6,047
43. Kardes Payi (2014–2015)
TV-PG | 70 min | Comedy, Drama, Family
The two brothers have a plumbing company and they are trying to invent something that would make the world a better place.
Stars: Ahmet Kural, Murat Cemcir, Seda Bakan, Emrah Kaman
Votes: 9,354
44. Pod prikritie (2011– )
60 min | Action, Crime, Drama
The specially trained agent Martin has been appointed to the most dangerous mission in Bulgaria - to go undercover in the gang of the mafia boss Djaro. On his way he has to encounter a lot ... See full summary »
Stars: Vladimir Penev, Zachary Baharov, Lyuben Kanev, Marian Valev
Votes: 24,369
45. It's Always Sunny in Philadelphia (2005– )
TV-MA | 22 min | Comedy
Five friends with big egos and slightly arrogant attitudes are the proprietors of an Irish bar in Philadelphia.
Stars: Charlie Day, Glenn Howerton, Rob McElhenney, Kaitlin Olson
Votes: 141,752
46. The Office (2005–2013)
TV-PG | 22 min | Comedy
A mockumentary on a group of typical office workers, where the workday consists of ego clashes, inappropriate behavior, and tedium. Based on the hit BBC series.
Stars: Rainn Wilson, John Krasinski, Jenna Fischer, Leslie David Baker
Votes: 215,447
47. Peaky Blinders (2013– )
TV-MA | 60 min | Crime, Drama
A gangster family epic set in 1919 Birmingham, England and centered on a gang who sew razor blades in the peaks of their caps, and their fierce boss Tommy Shelby, who means to move up in the world.
Stars: Cillian Murphy, Paul Anderson, Joe Cole, Helen McCrory
Votes: 75,931
48. Doctor Who (2005– )
TV-PG | 45 min | Adventure, Drama, Family
The further adventures of the time traveling alien adventurer and his companions.
Stars: Peter Capaldi, Jenna Coleman, Matt Smith, David Tennant
Votes: 156,351
49. Dexter (2006–2013)
TV-MA | 53 min | Crime, Drama, Mystery
Dexter Morgan is a Forensics Expert, but that's what he seems to be, as that's not what he really is. Dexter is a serial killer that hunts the bad.
Stars: Michael C. Hall, Jennifer Carpenter, David Zayas, James Remar
Votes: 522,449
50. Daredevil (2015– )
TV-MA | 54 min | Action, Crime, Drama
Matt Murdock, with his other senses superhumanly enhanced, fights crime as a blind lawyer by day, and vigilante by night.
Stars: Charlie Cox, Vincent D'Onofrio, Deborah Ann Woll, Elden Henson
Votes: 242,133


text:
Yep, same here, the Mormons and the Jehova Witness folks. Other than that
we used to have the teens with the magazines, but that was short lived.
zone 9
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|Table of Contents
|Vol. 3, No. 6, 2012
Issue release date: January 2013
|Section title: Original Article
Gain of FAM123B and ARHGEF9 in an Obese Man with Intellectual Disability, Congenital Heart Defects and Multiple Supernumerary Ring ChromosomesHochstenbach R. · van Gijn M.E. · Krijtenburg P.-J. · Raemakers R. · van 't Slot R. · Renkens I. · Eleveld M.J. · van der Smagt J.J. · Poot M.
Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands Corresponding Author
Ron Hochstenbach
Department of Medical Genetics, Division of Biomedical Genetics
University Medical Centre Utrecht, PO Box 85090, Mail Stop KC04.084.2
NL–3508 AB Utrecht (The Netherlands)
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In a 24-year-old man with mild intellectual disability, congenital heart defects and obesity, we identified up to 4 small supernumerary marker chromosomes (sSMCs) in blood metaphases. The ring-shaped sSMCs were derived from chromosomes 11, 12 and X as well as a fourth, unidentified chromosome. In interphase nuclei of epithelial cells from the urinary tract and buccal mucosa, the presence of the r(11), r(12) and r(X) was confirmed by FISH. Using Illumina Infinium 317K SNP-arrays, we detected 3 copies of the pericentromeric regions of chromosomes 11, 12 and X. The r(X) was present in 84–89% of cells in the various tissues examined, lacks the XIST gene, but contains FAM123B, a potential dosage-sensitive candidate gene for congenital cardiac abnormalities, and ARHGEF9, a candidate gene for intellectual disability. ARHGEF9 encodes collybistin (CB), which is required for localization of the inhibitory receptor-anchoring protein gephyrin and for formation and maintenance of postsynaptic GABAA and glycine receptors. We propose that the 2-fold increase in dosage of ARHGEF9 disturbs the stoichiometry of CB with its interacting proteins at inhibitory postsynapses. SNP alleles and short tandem repeat markers on the r(11) and r(X) were compatible with a maternal origin of both sSMCs through a meiosis II error. The sSMCs may have resulted from predivision chromatid nondisjunction, leading to anaphase lagging, followed by incomplete degradation of the supernumerary chromosomes.
© 2012 S. Karger AG, Basel
ARHGEF9 Congenital heart defect FAM123B Intellectual disability Mosaicism Multiple supernumerary marker chromosomes Secundum-type atrial septal defect
Small supernumerary marker chromosomes (sSMCs) are defined as additional centric derivatives smaller than chromosome 20 [Liehr et al., 2004]. Single sSMCs are detected in about 0.043% of unselected newborns, 0.077–0.11% of prenatal cases and in 0.29–0.43% of patients with intellectual disability [Liehr et al., 2004, 2006; Bartsch et al., 2005; Huang et al., 2006; Liehr and Weise, 2007; Forabosco et al., 2009]. Multiple sSMCs are among the rarest cytogenetic abnormalities. As estimated from reviewing 1,396 cases, roughly 1.4% of the cases with supernumerary markers have multiple sSMCs [Liehr et al., 2004], and, therefore, the frequency of such cases in patients with developmental delay can be estimated at 1 in 17,000–25,000. More than 30 cases have been described, as reviewed by Beverstock et al. [2003], Daniel and Malafiej [2003], Reddy et al. [2003], and Liehr et al. [2004]. Most of these cases concerned patients with developmental delay or intellectual disability, often in combination with dysmorphic signs and multiple congenital anomalies.
While several models for the generation of single sSMCs have been proposed [Liehr et al., 2004], the mechanism of origin of the multiple sSMCs is unknown. In 1 patient, these sSMCs are either small ring chromosomes, minute linear chromosomes, or both. In general, they contain centromeric heterochromatin and variable, but limited, amounts of pericentromeric euchromatin, either from the short arm, long arm, or both arms [Baldwin et al., 2008]. More recently, also sSMCs of a more complex architecture have been reported, containing material from 2 distinct chromosomes or non-contiguous regions from the same chromosome [Davidsson et al., 2010; Fei et al., 2011; Vetro et al., 2012]. The paucity of informative polymorphic DNA markers, together with chromosomal mosaicism, hampered the identification of the parental origin in cases with multiple sSMCs. As is evident from the literature [Beverstock et al., 2003; Daniel and Malafiej, 2003; Reddy et al., 2003; Liehr et al., 2004], any human chromosome can give rise to 1 of the multiple sSMCs in the patients described so far, with each patient appearing to harbor a unique set of sSMCs. Therefore, the origin of multiple sSMCs in an individual is most likely explained as the result of a single event, such as the breakdown and rearrangement of a haploid chromosome complement shortly after fertilization in a triploid zygote [Beverstock et al., 2003; Daniel and Malafiej, 2003].
Here, we report a new case of a patient with mild intellectual disability who has up to 4 small supernumerary ring chromosomes in metaphases from stimulated peripheral blood lymphocytes. Using FISH, array-CGH and array-based SNP-analysis, we determined the chromosomal origin and gene content of the sSMCs. In addition, using short tandem repeat (STR) and SNP markers, we investigated the parental origin of the multiple sSMCs.
The patient is a 24-year-old male with mild developmental delay, who, from the age of 7 on, gradually became obese. At the age of 20, his body mass index was 33.1. He had a congenital secundum-type atrial septal defect, a hemodynamically significant perimembranous ventricular septal defect and dysplastic aortic and pulmonary valves. The septal defects were surgically corrected at the age of 11 and the redundant tissue of the pulmonary valves was excised as well. He was operated for bilateral inguinal hernias at age 1, underwent left-sided orchidopexy at the age of 14, and surgical correction for a left-sided club foot. A detailed case report has been published [Joziasse et al., 2009].
Slides containing metaphases from phytohemagglutinin-stimulated lymphocytes from peripheral blood were prepared following standard methods. Metaphases were analyzed with GTG-banding at the 550-band level. FISH was performed according to standard methods [Liehr and Claussen, 2002] except that, after hybridization, slides were washed twice in 0.4× SSC/0.05% Tween-20 at 72°C for 5 min, followed by washes in 2× SSC/0.05% Tween-20 and 4× SSC/0.05% Tween-20 at room temperature for 5 min each. FISH on epithelial cells from buccal smears and urine was performed according to Rauch [2002]. Centromere-specific DNA probes were obtained from Abbott-Vysis and hybridized according to instructions provided by the manufacturer. A FITC-labeled telomere-specific TTAGGG peptide nucleic acid probe was obtained from DAKO and used according to protocols provided by the manufacturer. Array-CGH was performed according to Poot et al. [2007a], using the BAC-array described by Vissers et al. [2003]. SNP analysis was performed as described earlier [Poot et al., 2007b] using the Infinium HumanHap317K Genotyping BeadChip (Illumina Inc.) [Poot et al., 2010]. Data about the gene content of the sSMCs were compiled using the Database of Genomic Variants (DGV: http://projects.tcag.ca/variation), Genecards (www.genecards.org), Online Mendelian Inheritance in Man (OMIM; http://www.ncbi.nlm.nih.gov/omim), University of California at Santa Cruz genome browser (UCSC; http://genome.ucsc.edu), and UniProt (www.uniprot.org).
To investigate the parental origin of the supernumerary ring chromosomes, and to determine whether they originated from a meiosis I or II error, we selected STR markers located inside the chromosomal segments present in the small supernumerary ring chromosomes. For the r(11) these were D11S1395, D11S1920, D11S2005, D11S1313, D11S1357, and D11S4459, for the r(X) these were DXS7132 and DXS6785. Four additional STR markers on chromosome 11, located in the long arm distally from the segment within the r(11), were selected as internal controls (D11S1983, D11S2363, D11S4075, D11S4191). There were no suitable STR markers for the r(12). PCR reactions were performed on 50 ng genomic DNA isolated from peripheral blood. Initial denaturation was at 95°C for 10 min, followed by 33 cycles of denaturation at 95°C for 30 s, annealing at 55°C for 30 s and extension at 72°C for 30 s, and a final extension at 72°C for 30 min. PCR products were analyzed using an ABI 3130 automated sequencer (Applied Biosystems) with LIZ-500 fluorescent size standards and formamide (Applied Biosystems). GeneMapper software (Applied Biosystems) was used for data collection and analysis. The father was unavailable for investigation.
Karyotyping of the proband revealed sSMCs (fig. 1) in 98.5% of metaphases from lymphocyte cultures. The number of markers per metaphase varied from 0 to 4 (fig. 1A), with 3 markers being the most frequent number (in 49.5% of metaphases). The markers contained no telomeric DNA as demonstrated by FISH using telomere-specific peptide nucleic acid probes (fig. 1B), and are further referred to as sSMCs. The mother had a normal 46,XX karyotype in all 32 metaphases investigated.
FISH with DNA probes specific for the centromeres of each chromosome demonstrated that 3 small supernumerary ring chromosomes were derived from chromosomes 11, 12, and X (fig. 1C). The origin of the fourth supernumerary chromosome could not be determined because it was present in only 2.5% of metaphases in blood. The analysis of the distribution of the small supernumerary ring chromosomes in cultured and uncultured lymphocytes and uncultured epithelial cells is summarized in table 1. FISH using centromere-specific probes for chromosomes 11, 12 and X showed that 40% of interphase lymphocytes contained these 3 small supernumerary ring chromosomes. In interphase nuclei from urine sediment cells and buccal smears this was 35 and 30%, respectively. The percentages of cells containing different combinations of 2 small supernumerary ring chromosomes was 43–45% in blood and skin, the combination +r(11) and +r(12) being the least frequent in all tissues examined (table 1). In all tissues, the percentage of cells containing no supernumerary ring chromosomes derived from either chromosome 11, 12 or X was low (1.5–5.0%). The small supernumerary r(X) chromosome was present in the highest fraction of cells in all tissues examined (84–89%).
In order to determine the size and the gene content of the ring chromosomes, we initially performed array-CGH using the BAC-array described by Vissers et al. [2003], containing 3,343 BAC clones. This revealed a gain in 8p23.1, identified by a single BAC clone (RP11-80B8) and subsequently confirmed by FISH using RP11-235I5 [Joziasse et al., 2009], as well as a gain in 11q12.1 as indicated by BAC clone RP11-135H8. As a sex-mismatch DNA sample was used as reference for the array-CGH, no copy number gains could be identified for the X chromosome. A higher-resolution investigation was performed using the Illumina Infinium HumanHap317K Genotyping BeadChip. Combining all data from array-CGH, SNP-array and FISH analysis, we conclude that the r(11) contains material from the proximal regions of both the short and the long arm, encompassing 49 olfactory receptor (OR) genes and the genes TRIM48 and TRIM51. The r(12) includes mainly centromeric material, and is devoid of protein-coding genes. The SNP-array demonstrated that the r(X) contains material from the proximal part of the long arm of the X chromosome only, with 8 protein-coding genes. The delineation of the small supernumerary ring chromosomes is summarized in table 2, and the gene content in online supplementary table 1 (www.karger.com?doi=10.1159/000345241). The karyotype of the proband was designated as 46∼50,XY,+1∼4mar.ish dup(8)(p23.1p23.1)(RP11-235I5++),+r(11)(::p11.12→q12.1::)(D11Z1+),+r(12)(::p11.1→q11::)(D12Z3+),+r(X)(::p11.1→q12::)(DXZ1+).
To identify the parental origin of the small supernumerary ring chromosomes and whether they resulted from an error in meiosis I or II, we determined the segregation of SNP and STR markers located on the ring chromosomes of the proband and his mother (summarized in table 3). We tested 6 STR markers located within the segment present in the r(11). For 4 of these the maternal and paternal alleles in the proband could be identified, each showing an increased dosage of the maternal allele in the proband (table 3). We also tested 4 STR markers located more distally on the long arm of chromosome 11 that are not included in the r(11). All of these were informative, showing an equal dosage of the maternally and paternally derived alleles in the proband and his mother (table 3). These observations for the supernumerary r(11) chromosome are consistent with a maternal origin through abnormal segregation during meiosis II. This result is supported by observations on the transmission of STR and SNP markers located on the r(X). The single STR marker tested was heterozygous in the mother of the proband and homozygous in the proband. Five SNP markers located on the r(X) were heterozygous in the mother and homozygous in the proband. This finding is again consistent with a maternal origin of the r(X). Assuming that no recombination occurred between the markers analyzed, the haplotypes can be reconstructed (table 3) to provide the simplest explanation for the segregation of the markers. The SNP-array data also excluded a UPD for either chromosome 11 or 12 in the proband.
We report on a 24-year-old man with mild intellectual disability, congenital defects (secundum-type atrial septal defect and a left-sided club foot) as well as obesity. Cytogenetic studies revealed mosaicism for 0–4 sSMCs, 3 of which could be identified as small ring chromosomes derived from chromosomes 11, 12 and X, respectively. Analysis by SNP-array revealed that only the r(11) and r(X) chromosomes contained protein-coding genes.
Since the GATA4 duplication in 8p23.1 does not co-segregate with a cardiac defect in the family of our proband [Joziasse et al., 2009] and because a ∼4-Mb duplication containing GATA4 occurs in about 0.6% of the general population [Zogopoulos et al., 2007], it is unlikely that the additional copy of GATA4 is sufficient to explain the congenital heart defect in our patient. We therefore searched for putative phenotypic effects of the ring chromosomes. To do so, we investigated their gene content and compared our case with published cases with a similar, single sSMC or direct duplication covering the same chromosomal segment (online suppl. table 2). In addition, we determined whether the chromosomal segments within the supernumerary ring chromosomes have been described in the DGV as segmental trisomies occurring in normal, healthy individuals (table 2 and online suppl. table 1). The supernumerary r(11) harbors 49 OR genes as well as the TRIM48 and TRIM51 genes (online suppl. table 1). Based on the presumed gene function and the patterns of transcription of the genes on the r(11) in adult human tissues, there is no apparent relationship to the phenotype of our patient. This is consistent with the existence of several normal individuals carrying an sSMC derived from chromosome 11 of a comparable size (online suppl. table 2, also see the sSMC database compiled by T. Liehr and collaborators (http://www.fish.uniklinikum-jena.de/sSMC.html)). In contrast, individuals with a larger sSMC derived from chromosome 11, containing more material from 11q12.1, show a combination of severe motor delay, hypotonia, seizures and exotropia (sSMC database). In addition, both TRIM48 and TRIM51 are contained entirely within copy number gains detected in normal, healthy subjects (see table 2 and online suppl. table 1). Also CNV of OR genes has been reported, including genes located in the OR cluster in 11q11 [Hasin et al., 2008; Young et al., 2008]. According to the DGV, 28 of the 49 OR genes occur in copy number gains described by several investigators to occur in healthy individuals (online suppl. table 1). The supernumerary r(12) does not harbor protein-coding genes. In addition, the chromosome segment contained in the r(12) has been reported by multiple studies as a copy number gain in healthy individuals (DGV). The sSMC database shows several examples of individuals carrying a single sSMC containing pericentromeric euchromatin from chromosome 12, but who lack an apparent clinical phenotype (see online suppl. table 2). Also, Liehr et al. [2004] concluded from a review of 1,396 published cases that a single sSMC without euchromatic content and without UPD of the structurally normal sister chromosomes does not lead to phenotypic consequences. Based on these observations, it is highly unlikely that the supernumerary r(11) and r(12) chromosomes contribute to the clinical symptoms of our patient. Assuming that the findings in blood are representative for most other tissues and organs, a significant phenotypic effect of the fourth, unidentified sSMC is also unlikely, because in comparison to the other 3 sSMCs, it is present in a much lower percentage of cells (table 1). In addition, it is possible that, similar to the r(12), it does not contain protein-coding genes.
In contrast, the genes on the supernumerary r(X) are more likely to contribute to the phenotype of our patient. Firstly, the r(X) is the most abundant sSMC in both blood (85% of cells) and epithelial cells (84–89% of cells). Therefore, most cells contain 2 copies of the genes on the r(X), in contrast to males with a normal karyotype, who have 1 copy. Secondly, the r(X) does not contain the XIST gene, located in Xq13.2, and therefore it is reasonable to assume that the genes present on the r(X) are transcriptionally active. Thirdly, several patients with an sSMC derived from the X chromosome that contains material from proximal Xq only have been described in the literature (summarized in online suppl. table 2). All of these lack the XIST gene, as shown either by their small size or by lack of hybridization signal with a XIST-specific DNA probe. Although comparison to our patient may be complicated by varying sizes of sSMCs and by different degrees of mosaicism, 9 out of 12 of the previously reported patients have intellectual disability or severe structural brain malformations (online suppl. table 2), similar to our patient. An apparently normal phenotype has been observed in 3 cases. Amiel et al. [1995] described a healthy newborn boy with an X-derived sSMC that was otherwise not characterized in more detail, but that has been detected prenatally in all cultured amniocytes investigated. Starke et al. [2003] described a girl, normal at birth, with a min(X) sSMC that was identified prenatally in 65% of cultured amniocytes. A boy with a small supernumerary r(X) in 25% of blood metaphases had no signs of intellectual disability when observed at 1 year of age [Chen et al., 2006]. In these cases the percentage of cells containing the sSMC may be low, as in the boy described by Chen et al. [2006], or the sSMC may be too small to be of clinical relevance [Amiel et al., 1995; Starke et al., 2003]. We conclude that these observations, together with those on our patient, strongly suggest that supernumerary r(X) chromosomes containing the region between the centromere and the breakpoint in Xq12 are associated with intellectual disability, but only if the degree of mosaicism exceeds a certain, as yet unknown, threshold.
Of the genes on the r(X) that have not been identified in phenotypically neutral copy number gains (see DGV), ARHGEF9 and FAM123B have been associated with hereditary disease (see OMIM). These genes are likely dosage-dependent candidate genes for explaining certain clinical features in our patient. ARHGEF9 (also known as CDC42 guanine nucleotide exchange factor 9) encodes the collybistin protein (CB), a brain-specific GDP/GTP exchange factor, that is essential for clustering of specific GABAA and glycine receptors at inhibitory postsynaptic sites in specific regions of the mammalian central nervous system [reviewed by Papadopoulos and Soykan, 2011]. At inhibitory synapses, CB is required for formation of a hexagonal lattice, built from gephyrin trimers, beneath the postsynaptic plasma membrane [Harvey et al., 2004; Papadopoulos et al., 2007]. In its inactive state CB binds to gephyrin trimers in a 1:1 ratio during microtubule-mediated transport of the trimers to synaptic sites. Observations on CB-deficient mice indicate that CB plays a role in synaptic plasticity and affects the regulation of the excitation/inhibition balance [Papadopoulos et al., 2007, 2008; Jedlicka et al., 2009; Poulopoulos et al., 2009]. In male patients, a missense mutation in ARHGEF9 is associated with hyperekplexia, epilepsy and decline of psychomotor development [Harvey et al., 2004]. A deletion of this gene and a nonsense mutation have been identified in males with intellectual disability and epilepsy [Lesca et al., 2011; Shimojima et al., 2011]. In female patients, balanced translocations that disrupt ARHGEF9 are associated with mild intellectual disability and hyperarousal [Marco et al., 2008], or with severe intellectual disability, epilepsy and anxiety [Kalscheuer et al., 2009]. These findings support the hypothesis that the 2-fold increase in gene dosage of ARHGEF9 in the majority of cells in our patient is causal for the intellectual disability, probably by perturbing the stoichiometry between CB and its interacting proteins [Poot et al., 2011]. We speculate that a 2-fold increase in ARHGEF9 gene dosage leads to excess amounts of gephyrin-free CB molecules that bind to the cytoplasmic NL2 domains, thereby blocking the anchoring points required for gephyrin lattice assembly. However, other possibilities cannot be excluded, such as effects on the relative amounts of CB isoforms that are produced by alternative splicing.
The FAM123B gene has been found to carry somatic loss of function mutations in up to 30% of Wilms' tumors [Rivera et al., 2007]. Germline mutations cause osteopathia striata with cranial sclerosis [Jenkins et al., 2009]. The gene encodes a component of the β-catenin degradation complex that inhibits WNT signaling and may function in the transcriptional regulation of cellular differentiation [Rivera et al., 2009]. During mouse embryogenesis, the gene is strongly transcribed in the central and peripheral nervous system [Comai et al., 2010]. These observations support a role in intellectual disability as seen in our patient. Because perturbation of WNT signaling has been linked to congenital heart defects in animal models, the additional copy of FAM123B, possibly in conjunction with the GATA4 duplication, may also have contributed to the congenital heart defects seen in our patient [Joziasse et al., 2009]. Contributions from the additional copies of other genes on the r(X) cannot be excluded. For example, the ZC4H2 and ZC3H12B genes both encode zinc-finger proteins, the latter being transcribed in the heart of fetal mice (see the Mouse Genome Informatics database; www.informatics.jax.org).
Both the r(11) and r(X) are present in ∼70 and ∼85% of uncultured peripheral lymphocytes, respectively. This allowed us to determine the segregation of SNP and polymorphic STR markers in order to reconstruct haplotypes for the proband (table 3). Four STR markers on the r(11) were informative. As in each case the maternal allele occurred at a higher dosage than the paternal allele, a maternal meiosis II error is the most likely explanation for the origin of the r(11). Since the father of the proband was not available for investigation, we cannot completely exclude a paternal meiosis I error, a fertilization by 2 sperm cells, which both share the same haplotype for the chromosomal segment within the r(11), or fertilization by a diploid spermatozoon resulting from a paternal meiosis II error. However, these latter scenarios would provide an explanation only if it is further assumed that the father and the mother have an identical haplotype at proximal 11q. Given that there are no indications for consanguinity between the parents, this appears remote. Also, the SNP marker data and 1 STR marker on the r(X) do not support a paternal origin of this sSMC.
In order to explain the occurrence of the sSMCs in our patient, a mechanism must be invoked that causes multiple additional chromosomes to be present in the zygote by misdivision during meiosis II in the fertilized oocyte. As a next step, it must be assumed that the additional chromosomes are incompletely degraded, leading to mitotically stable supernumerary chromosomes that are necessarily small when not interfering with viability. This, then, must happen in such a way that, preferentially, ring chromosomes are formed. First, a model proposing that the multiple sSMCs are the result of fertilization by 2 spermatozoa [Beverstock et al., 2003] is not supported by the DNA marker studies in our patient (although such a scenario may provide an explanation for other patients with a r(Y) as 1 of the multiple sSMCs, see the case described by Weimer et al. [2006]). Another model is based on the incomplete degradation of a non-extruded second polar body during meiosis II [Daniel and Malafiej, 2003]. This mechanism would be compatible with the DNA marker studies in our case. Predivision chromatid nondisjunction can lead to gain of up to 6 chromosomes in the zygote, and may account for the majority of meiosis II errors [Handyside et al., 2012]. We propose that anaphase lagging can explain this. The meiosis II error has to be followed by incomplete degradation of the supernumerary chromosomes, leading to retention of multiple small rings. As demonstrated by array-CGH, about 80% of the non-acrocentric, ring-shaped sSMCs are formed by a break within the centromeric alpha repeat array, as they contain unique-sequence material from 1 chromosome arm only [Baldwin et al., 2008]. This is seen in our patient for the r(12) and the r(X). The other 20% are formed from proximal breaks in both arms [Baldwin et al., 2008], similar to the r(11) in our patient. Array-based investigation of chromosome rearrangements in single cells from cleavage-stage embryos shows that the gain or loss of an entire chromosome arm is the most common type of abnormality during the first mitotic cell divisions [reviewed by Voet et al., 2011], and possibly this is the case also when the multiple sSMCs are generated. These observations are supported by studies of spindle defects and DNA breaks in tumor cells [Martínez-A and van Wely, 2010]. Spindle defects can cause chromosomes to lag behind on the metaphase plate if the kinetochore is attached to both spindle poles. In such lagging chromosomes the opposite tension generated by the microtubules can cause double strand DNA breaks in or adjacent to the centromere, reminiscent of observations of McClintock in maize, leading to a deletion chromosome and a complementary small ring chromosome [Baldwin et al., 2008]. Clearly, these hypotheses need further in-depth studies. In a separate review, we will examine these hypotheses as a putative general model to explain the rare cases of multiple sSMCs, each being derived from a different chromosome.
The authors would like to thank the proband and his family members for their participation in this study, and C.G.F. de Kovel for assistance in finding suitable DNA markers. In addition, we are grateful to J.P.M. Geraedts of the Maastricht University Medical Center, Maastricht (The Netherlands), for stimulating discussions and helpful suggestions.
Ron Hochstenbach
Department of Medical Genetics, Division of Biomedical Genetics
University Medical Centre Utrecht, PO Box 85090, Mail Stop KC04.084.2
NL–3508 AB Utrecht (The Netherlands)
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Accepted: September 27, 2012
Published online: November 20, 2012
Issue release date: January 2013
Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 3
ISSN: 1661-8769 (Print)
eISSN: 1661-8777 (Online)
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Publication Name: Reno Evening Gazette
Location: Reno, Nevada
Pages Available: 338,126
Years Available: 1876 - 1977Learn More About This Publication
Reno Evening Gazette (Newspaper) - September 22, 1890, Reno, Nevada
THE STATE FAIR! QO and make it a Great Success. Vacation Thla weak juut persuade your to do the and attend the Fair. VOL. XXIX. RENO, WASHOE COUNTY, NEVADA, MONDAY, SEPTEMBEK 22, 1890. MISCELLANEOUS. H. LETER, THE BON TON TAILOR, Has just received a fine line of Fall goods, both FRENCH AND DOMESTIC. made to order cheaper than nny other place in the city A perfect fit guaranteed or no VIRGINIA STRKET, NEAR COMMERCIAL ROW, RENO, NEVADA. _ coscp _ OPERA HOlSk JOHN PIPER I.KSSBE. McAuliffe and Slavin Under Bonds. 4 SWISS VILLAGE The Weather East of Missouri River. the ONE NIGHT 22, 1890, Portuguese u Ask for Appearance of Favorite Irish Comedian, J. I'KEK-A-BOO." Under the manngemenit of Augustus Pitou, his romantic four-act comedy, "MILES ABOON." Mr. Scanlan will aing the following wnrs, written and composed by him especially for this play YOU AND I I.OVK MY MA.OGIK." MY LOVE, OH LIVK." THK SWING 8ONG." his nlways PEEK-A-BOO." SCALU OF PRICES Drews Circle oo Dress Circle Admission....... i oo Balcony 75 Admission Balcony.................. Boxen 500 Box .sheet now open at Nasby's Dazaar. The Clarendon. F HOTKL IN RENO, SITUATKD on Commercial Row, directly opposite the Depot. Newly construct d and hard; finished throughout. Klectrlc light, gas, hot and cold water fixtures in every room. Bath-room and every accommodation for guests. First- class trade invited. Terms reasonable and tnblc first-class Fine bar attached, with the very choicest of nines, liquors and cignrs. nep2o A. J. CLARK, Proprietor. The PajrtliHtM LONDON, Sept, is reported that Slaven and McAuliffe have been arrested. McAulifle was arrested at his lodgings in this cjty. Slavin was arrested on hif- arrival from his train- ing quarters at dover. They will be arranged this uf ternoon on a charge of conspiricy to commit a breach of the peace. Upon his arrival at the rail- way entered a cab and immediately placed under arrest. He was conveyed quickly to the Lani- police station 'when both were arranged and bound o'ver under 000 pounds each to appear tomorrow.' BIVERSIWS HOTEL. The rate at the Riverside Hotel Fair week will be 50 per day each when- two persona occupy one room and per day for oue person. The hotel will trarmport the quests to and fron> the Fair grounds free of charge. No room without board. R. CHAMBERLAIN, BlSwl 1'roprietor. Windmill and Outfit T TRUCKKB. CONSISTING OF ONE Regulator wind mill, one wind mill frame, made out of whole timbers 33 feet hlyh, stories, well secured with large iron rods. One gallon red wood tnulc, one red wood tan both with good covers, nnd one bronze weather indicator. hot further pai titulars, enquire of Mrs. M. Mai'- tden, at Truckce, or A. O. r ol the Reno CAXItTTIv. 320 Carts, Etc WJ. CARRIES THE 1IEST o class of goods to be found on the Agent for Studebnker's Fine Carriages, which cannot be excelled, agent for Fraier'' Koad Carts and best; also agent for the U. S. Carriage Co. 'the Best Horse-shoeing in J. UTJOECE By Cable and Associated LONDON, Sept. liquidators of the Cape of Good Hope Bank report a deficit in addition to total loss of its fully paid up capital and reserve fund, which amounts to pounds. The report recommends that a first call be made on the shareholders for one hun- dred pounds per share, payable in ten monthly installments. Klllrit by By Cab'c and Associated Press.] LONDON, Sept. advicef from Goa. India, state that 18 persons killed and 50 wounded in an election riot at that place by Portuguese troops who fired on the crowd of Republicans The Portuguese residents of Bombaj have resolved to apply to tho.pngliHl unJess the Portuguese Government Ye dresses their grievances. Vartci.v IV. at her By Associntrd Pros'. WASHINGTON, Sept. has fallen in the lower Mississippi valle> and in the Gulf and South Atlantii States; elsewhere the weather has re- mained fair. The temperature lias fallen in New England, Minnesota, Wisconsin, Iowa, Kansas and Texas, und it has risen or remained stationary elsewhere. Heavy Fire By Cable and Associated Press.] Sept. village of Ruthi St. uull is on fire, and three hundred houses uro already destroyed. A loss of one life is reported, and the people are destitute. A Fnrnnornien'H Ntrikr. By Cable and Associated Press.] GiMbaow, Sept. Scotch furuaceuien have struck for higher wages, and the furnaces are being iilown out. The iron market is excited in consequence of the etriko. PROFESSOR ALFRED IMYlNAiW Gives thorough instruction in Vocal and Instrumental Music Orders may be left at C. J Brookins'. Reno BANK NOTICE. DURING HAIR WEEK will close each


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Saint Inigoes Real Estate
Saint Inigoes is located in Maryland. Saint Inigoes, Maryland 20684 has a population of 959. Saint Inigoes 20684 is less family-centric than the surrounding county with 14.46% of the households containing married families with children. The county average for households married with children is 37.93%.
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If you're looking for anime similar to Kaleido Star, you might like these titles. All recommendations are made by Anime-Planet users like you!
Kyoko moves to the big city with the prince of her dreams Shotaro; he wants to make it big in the entertainment business, so she works hard at many different jobs to support him as he achieves his dream. However, one day, Kyoko accidentally discovers the horrible truth: the love of her life thinks of her as a 'plain and boring woman!' Outraged, Kyoko swears revenge – she will make it even bigger than Shotaro in the entertainment world. The only question is, how will she fulfill her desire?
3 votes
I agree
In both shows you see the struggle of two girls trying to succed. They both start off with the left and often they end up being hated by the rest. Nothing lets them down and they as they try to exel at what they do, proving to everyone that there is more to them then meets the eye. Even though one is about a circus performer and the other about an actress, both shows are about searching for stardom
Both of these animes feature prominent female characters, and quick character development both on the part of story telling and on the part of the character growing into themselves as part of the story.
Both of these shows are not only intensly satisfying to the viewer, but they portray a female protagonist who just won't give up. I would definitely say that Skip Beat! has more comedic elements, but both shows are light hearted and wonderful to watch. These are two of my favorite shows EVER.
While examining an old Go board in his grandfather's basement, twelve-year-old Shindo Hikaru is possessed by the restless spirit of Sai, an ancient Go master who has waited for over one thousand years to play the Hand of God: the perfect move. Sai convinces Hikaru to act as a vessel for making his moves, but it is soon clear that Hikaru also enjoys Go and wants to play his own games. Moreover, the rules of Go have changed since Sai's time, and Go players from all over the world are now much stronger, having had the benefit of hundreds of years of evolution and experimentation by the masters before them. Can this unlikely pair form a successful partnership and rise to the top of Japan's Go community, and can Sai finally play the Hand of God and find some peace?
2 votes
I agree
There is a same structure in both series: getting to the top, starting from the lowest skill level possible. While Kaleido Star however is more focussed on glamour, Hikaru no Go is mainly focussed on the game itself. The characters of Kaleido Star are however alot deeper than the ones in Hikaru no Go and there is more humor in Kaleido Star. if you'd rather look at boardgames than at acrobatics and if yo uare more fond of historical settings, check out Hikaru no Go. If you are however looking for something with more action than Hikaru no Go and deeper characters, check out Kaleido Star
If you enjoy watching a main character develop and grow before your very own eyes like Sora in Kaleido Star, I have a feeling that you'd also be attracted to Hikaru from Hikaru no Go. Both anime have light humour and a supernatural companion (Sai in Hikaru no Go, and Fool Kaleido Star). Hikaru no Go has more intense battles and more drama. I'm confident that you'll enjoy Hikaru no Go if you enjoyed watching Sora develop.
Awayuki Himeno is a normal schoolgirl who is in a bind: her father's remarriage yielded two new cruel stepsisters, and to top it off, she meets seven men who call themselves Liefe Knights. They reveal to her that she's a Pretear, someone who can lend powers to them when their powers aren't enough to defeat the evil creatures called mayouchuu. Now, she has to fight the ambitious Fenrir, whose only purpose is to leech the life force from all living beings. Can Himeno save the world and find a way to deal with her growing feelings for one of the Liefe Knights?
1 votes
I agree
Both anime have a young girl striving to get along in a new life. The young girls struggle with new families, whether adopted or circus. In addition, the animation styles are similar; both are very bright and colorful with airy themes.
Misaki Suzuhara is a young girl who traveled to Tokyo to live with a relative, but ended up becoming involved in the greatest game of all time: Angelic Layer! In this fast-paced competition, players customize dolls and fight them in arenas of all sizes, hoping to gain experience and perhaps win the greatest tournament of them all! With new friends to meet and new enemies to defeat, the best time of Misaki's life seems to be just beginning. Join Misaki as she struggles to be the best, even in the face of overwhelming odds...
1 votes
I agree
Kaleido Star and Angelic Layer have girl power! You might find meaning in either of these if you are a 12 year old girl. They have a very light plot and light angst, and are really good for a laugh on a Saturday afternoon when you have nothing to do!
It is the year 2356 AD, 189 years after a shockwave from a distant supernova decimated the Earth. Since that fateful day, humanity has begun training for a final mission to protect the planet from the inevitable oncoming 2nd shockwave - a mission whose failure means the annihilation of mankind. For Katase and her friends, their training at the foundation Stellvia is just the beginning of an adventure that could lead to saving the world, or seeing its end...
1 votes
I agree
While these series have little in common when it comes to theme, genre, plot or character sub-types; they are very similar in tone. Both Stellvia and Kaleido Star are very hopeful shows with a complementary amount of realistic drama and a moderate dose of comedic relief.
Without being too sappy or too cute, these shows are near opposites to many of the darker and more twisted shows out there. If you are looking for something epic and uplifting and you liked one of these shows, you will surely like the other.


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This is one method of preparing absinthe: pour it over a sugar cube (or sugar) which you then light on fire to caramelize it. Then, mix with water. A sugar cube would work better than the loose sugar that I used, since it will burn longer (and caramelize more thoroughly.)
The more traditional method is simply to run a slow stream of water over ice, called "louching" which creates the same beautiful clouding of the Absinthe liquor. Here's a Youtube video showing that method.


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3M Biometric Access Control Readers Integrated with Schneider Electric Building Management Solutions
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This program is open to anyone having a degree in the Life Sciences area, such as Biology, Biochemistry, Biotechnology, Chemistry, Genetics, Medicine, Pharmacy, Veterinary. It aims to train researchers in Molecular Medicine and in Post-Genomics, focusing particularly on Molecular Oncology. Students can opt for basic or applied research projects.
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Taught courses
Molecular Oncology, Statistics, Bioinformatics, Genomics, Proteomics, Cancer Genetics, Drug Discovery, Developmental Biology, Immunology. Students are also given the opportunity to attend courses to develop complementary skills, such as How to give oral and poster presentations, Scientific Writing, Ethical Issues History of Medicine and Science Communication.


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Card Games
Special Decks
Designed by James Ernest. Published by Cheapass Games. For 3-6 players. Nominated for Origins award 1998. A two-minute thrill ride. It's a freeform card game in which players are falling, fighting, and struggling to hit the ground last. There are no turns in this game. Everyone is playing at once. One player deals from a mostly-shuffled deck, while the other players play their cards in real time. The Dealer isn't falling, he just distributes the cards and moderates the game. The other players receive stacks of cards, like Skip, Stop, Hit, and Push, and try to cope with them as quickly and accurately as they can. Sitting on the bottom of the deck are five Ground cards: when you get a Ground card, you are out, and the last player to hit the Ground wins. To win a game of Falling, you have to be lucky, fast, and clever. Or at least two out of three.
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Koding Launches 2nd Annual Global Virtual Hackathon
Sponsored by IBM, the event is expected to bring together more than 100,000 developers worldwide to compete for $150,000 in prizes.Koding, a San Francisco-based cloud development organization, this week announced its second annual global virtual hackathon, set for Dec. 12 and 13. The event will be sponsored by IBM and is expected to draw more than 100,000 participants worldwide, which is expected to set a new Guinness World Record—surpassing last year's inaugural event, which set the record for the largest-ever virtual hackathon. "Last year, we set a new record for the largest virtual hackathon," Devrim Yasar, CEO and co-founder of Koding, said in a statement. "Koding's cloud-based software development platform enables this type of collaboration at scale. We plan to double last year's participant count in 2015. In parallel, we're introducing our upcoming product, Koding for Teams, to the hackathon participants. This new product builds on our current platform and allows teams to create and manage their own unique development environments with ease and to do it all in the cloud." IBM's sponsorship of the event is part of the company's strategic relationship with Koding, a developer community and cloud-based developer environment that enables users to easily collaborate to write and run apps on a Web browser. Confirmed hackathon participants will receive an invitation for a free trial of IBM Bluemix, IBM's platform-as-a-service offering based on Cloud Foundry.
"We are working with Koding for this virtual hackathon as part of our commitment to promote open-source technology and support the talented community of developers who are dispersed all over the globe," Sandy Carter, general manager of Cloud Ecosystem and Developers at IBM, said in a statement. "Cloud-based open-source development platforms like Koding make it easier to get software projects started, and hackathons are a great place to show how these kinds of platforms make software development easier and more fun."
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Experienced Ebook Writer Needed
This project received 14 bids from talented freelancers with an average bid price of $436 USD.Get free quotes for a project like this
Project BudgetN/A
Total Bids14
Project Description
I need an experienced eBook writer to read and summarize the core concepts from 10 weight loss books. All books will be provided in digital format. Per book, I will need 5 pages, 250 words per page. You must use your own language and convey the summary in your own words without using any of the words used by the author of the work. You will be signing a legally binding agreement asserting that none of the material you provide has been plagiarized.
After interested applicants are screened, the finalists will be issued the specific content to be pulled and summarized from every book.
Good Luck!
Skills Required
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- Set your budget and the timeframe
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Apache has been the most popular web server on the Internet since April 1996.
Certificate provided by GeoTrust.
RapidSSL certificate provider.
This site is hosted on Amazon infrastructure.
The Sender Policy Framework is an open standard specifying a technical method to prevent sender address forgery.
PHP is a widely-used general-purpose scripting language that is especially suited for Web development and can be embedded into HTML.
A quick and simple placeholder service.
New Relic is a dashboard used to keep an eye on application health and availability while monitoring real user experience.
JQuery is a fast, concise, JavaScript Library that simplifies how you traverse HTML documents, handle events, perform animations, and add Ajax interactions to your web pages. jQuery is designed to change the way that you write JavaScript.
jQuery UI provides abstractions for low-level interaction and animation, advanced effects and high-level, themeable widgets, built on top of the jQuery JavaScript Library, that you can use to build highly interactive web applications.
Google Hosted Libraries is a globally available content distribution network for the most popular, open-source JavaScript libraries.
FancyBox is a tool for displaying images, html content and multi-media in a Mac-style "lightbox" that floats overtop of web page.
Allows a user to make a website more sociable and connected with integrations from the hugely popular Facebook website.
This page uses the viewport meta tag which means the content may be optimized for mobile content.
The AJAX Libraries API is a content distribution network and loading architecture for the most popular, open source JavaScript libraries.
A family of web feed formats used to publish frequently updated content such as blog entries, news headlines or podcasts.
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More Videos...
Small Turbo Supra vs. '08 997 Porsche Turbo
Some explorations on the Dyno and casual highway pulls of the n/a conversion Supra with 50 trim and AEM compared to a '08 997 with Exhuast and chip
More Project STi action
We test drive the Project STI, do some burn outs, recieve mental theorapy from our financial advsior, meet a girl evo driver for a tune and check the progress on race prep
Amazing 530 WHP Pump Gas STI
This is one opf the nicest steet cars we have ever put together. 530 whp on pump and meth on the stock ecu and a car which really handles amazingly. A geat combination.
468 TQ and 418 WHP Stock Turbo Evo IX on Pump and Meth
Stage II Evo IX with Intake, Exhuast, MBC and Fuel pump makes loads of power with Dyno Flash and Aquamist


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Vacation rental in Oliver, British Columbia, Canada
Come and stay in the heart of Okanagan Wine country. This 1000 sq foot, self-catering, daylight basement suite is the perfect location to explore the valley. Close to two golf courses, a 5 minute walk to main street, with views overlooking the valley, this oasis in the desert is the ideal place to vacation.
Make Oliver your summer or winter destination. Use the two touring bicycles to amble along the banks of the Okanagan River using the paved hike and bike trail, or take the back country road to visit a dozen or more wineries.
In the winter, you are 45 minutes from Mount Baldy with its powder snow and no lineups. Return to the valley and relax in the hot tub with a glass of local wine.
Your home away from home in the wine capital of Canada.
10% discount for 7 or more night stay. Complimentary bottle of local wine for a 3 night stay.


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Added to Cart
Ovela Luxe Bean Bag Lounger (Yellow)
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Ovela Luxe Bean Bag Lounger (Yellow)
Relax indoors or outside
FREE SHIPPINGWas $59
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Lie back and relax on this comfortable water-resistant lounger – you can even lounge in the pool!
- Chill out at home or in the garden
- Easily move the lounger around
- Float in the pool for the ultimate in relaxation
Lounge around in style on the Ovela Bean Bag Lounger. This soft, squishy bean bag has a classy look that complements any decor, whether you place it by the pool or in front of the TV.
Water-resistant and durable, this luxurious lounger can be used outside and will even float on the pool. The exterior is easy to clean and maintain, making it perfect for everyday use.
- Water-resistant material
- Suitable for indoor and outdoor use
- Made from 420D polyester
- Floats on water (only with beans)
- Luxuriously large seat: 120cm long, 110cm wide and 65cm high
Note: Beans not included. 500L of polystyrene beans recommended.
This Product is offered and supplied by Kogan Australia Pty Ltd pursuant to the Terms and Conditions.
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Politicians and Poachers
The Political Economy of Wildlife Policy in Africa
By (author) Clark C. Gibson
Series edited by Randall Calvert Thrainn Eggertsson
Format: Hardback
Normal Price: $205.00
Your Price: $184.50 AUD, inc. GST
Shipping: $7.95 per order
You Save: $20.50! (10% off normal price)
Plus...earn $9.22 in Boomerang Bucks
Availability: Available to Backorder, No Due Date for Supply
Politicians and Poachers by Clark C. Gibson
Book DescriptionAlthough wildlife fascinates citizens of industrialized countries, little is known about the politics of wildlife policy in Africa. In this innovative book, Clark Gibson challenges the rhetoric of television documentaries and conservation organizations to explore the politics behind the creation and change of wildlife policy in Africa. This book examines what Clark views as a central puzzle in the debate: Why do African governments create policies that apparently fail to protect wildlife? Moving beyond explanations of bureaucratic inefficiency and corrupt dictatorships, Gibson argues that biologically disastrous policies are retained because they meet the distributive goals of politicians and bureaucrats. Using evidence from Zambia, Kenya, and Zimbabwe, Gibson shows how institutions encourage politicians and bureaucrats to construct wildlife policies that further their own interests. Different configurations of electoral laws, legislatures, party structures, interest groups, and traditional authorities in each country shape the choices of policymakers - many of which are not consonant with conservation. This book will appeal to students of institutions, comparative politics, natural resource policymaking, African politics, and wildlife conservationists.
Buy Politicians and Poachers book by Clark C. Gibson from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780521623858
(228mm x 152mm x 16mm)
Pages: 262
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 13-Jun-1999
Country of Publication: United Kingdom
Other Editions...
Books By Author Clark C. Gibson
Samaritan's Dilemma, Hardback (September 2005)
The authors argue that much of foreign aid's failure is related to the institutions that structure its delivery. They explore the workings of Sida and find that Sida's institutions lead to perverse incentives and poor outcomes in the field. The authors offer concrete suggestions about how to improve aid's effectiveness.
Politicians and Poachers, Paperback (August 1999)» View all books by Clark C. Gibson
This book explores the politics of wildlife conservation policy in Africa, specifically Zambia, Kenya, and Zimbabwe.
» Have you read this book? We'd like to know what you think about it - write a review about Politicians and Poachers book by Clark C. Gibson and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
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Address: Boomerang Books, 878 Military Road, Mosman Junction, NSW, 2088
© 2003-2017. All Rights Reserved. Eclipse Commerce Pty Ltd - ACN: 122 110 687 - ABN: 49 122 110 687
For every $20 you spend on books, you will receive $1 in Boomerang Bucks loyalty dollars. You can use your Boomerang Bucks as a credit towards a future purchase from Boomerang Books. Note that you must be a Member (free to sign up) and that conditions do apply.


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New Shopping Cart Checkout HTML CSS - 5 Templates
This project was successfully completed by ayudeveloperssl for $190 USD in 4 days.Get free quotes for a project like this
Project Budget$30 - $250 USD
Completed In4 days
Total Bids5
Project Description
Need someone to create 5 new template pages to be used within the Body an existing website
Deliverable will include 100% working HTML pages to include: html, css, images, etc. I will take what you create and then turn this into a template on my website - most of what you do will simply 'plug-in' to my other system
I have screenprints and notes of exactly what I want. This screenprints are from a live operational website. If you want to copy exactly what is there, that is fine, but nothing in the html or css can point back to their website
[url removed, login to view]
- Everything should be copied as much as possible!!
- These 5 pages must use a shared CSS file
- should be generically colored with shades of Grey
- will include such items as DIV popups, Mouse hover popup displays,
- each of the 5 template pages must have a new horizontal image created, which should be similar to the screenprints.
- On page Error Messaging labels/messages must be built in
To see this 'live'
- goto [url removed, login to view]
- add an item to your cart
- click CHECKOUT (top right)
- Go thru as much of the process as possible and you will see most of the items in the above Google Drive link.
Completed by:
Skills Required
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- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
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From: Chris Darlington <firstname.lastname@example.com>
Thanks for sharing Jan ,
I'll be very disappointd if my new rhizome of INCANTATION doesn't bloom
in June. What are the dimensions of the flower , it looks large. Is it
really tall ?
Your image is razor sharp , I guess I'll have to break down one day and
get a digital as well.
email@example.com wrote:
> From: email@example.com
> hope the picture gets through this time!
> Janet
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Lamb Chops With Mint Pesto
|Packed mint leaves
|1 Cup (16 tbs)
|Parsley leaves
|1⁄2 Cup (8 tbs)
|1⁄4 Cup (4 tbs)
|3 Clove (15 gm), chopped
|Extra virgin olive oil
|1 1⁄2 Cup (24 tbs)
|White wine vinegar
|2 Tablespoon
|1 3⁄4 Teaspoon
|1⁄4 Teaspoon
|Lamb shoulder chops
|56 Ounce
1. Place mint, parsley, walnuts, and garlic in a food processor. Process until chopped. With machine on, pour 1 cup olive oil through feed tube in a slow stream. Continue to process until pesto is finely chopped but not pureed. Season with vinegar, 3/4 teaspoon salt, and 1/4 teaspoon pepper. Set mint pesto aside.
2. Light a hot fire in a grill or preheat a broiler. Trim excess fat from chops. Season with remaining 1 teaspoon salt, 1/4 teaspoon pepper, and 2 tablespoons olive oil. Grill or broil 3 inches from heat 4 minutes on one side. Turn and cook 2 minutes more, or until cooked to desired doneness. Serve with mint pesto
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 8929 Calories from Fat 7354
% Daily Value*
Total Fat 808 g1243.3%
Saturated Fat 24.7 g123.3%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 6235.5 mg259.8%
Total Carbohydrates 16 g5.2%
Dietary Fiber 5.8 g23.3%
Sugars 1.1 g
Protein 358 g715.2%
Vitamin A 80.4% Vitamin C 93.7%
Calcium 18.2% Iron 26.6%
*Based on a 2000 Calorie diet


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Editor's Note: Hearing With My Heart
Editor-in-chief Liz Vaccariello recalls the sounds of her life.
I was recently inspired to think about sound, thanks to Trevor Cox's story in the May issue of Reader's Digest. I'd never considered the isolated sense of hearing outside the context of music and noise ("Can you please turn that television down?!"). So one afternoon I went for a walk and asked myself, What are my sonic memories? Perhaps you'll be inspired to do the same.
I'm a kid in the backseat of the family car. I hear the confident knock of my father's class ring on the steering wheel. I love this sound.
I'm a girl preparing for a piano recital. I hear the steady click of the metronome keeping me in perfect time. I resent this sound.
I'm a traveler who's walked right up to the edge of Exit Glacier in Seward, Alaska. I hear the creaky groans and happy pops of ice moving, pulling, shifting, settling. I am in awe of this sound.
I'm a new mother, peering into her daughter's crib. I hear the soft sucking of fingers in a tiny mouth. I cherish this sound.
I'm a daughter, sitting beside her dad in his final days. He's sleeping in his bedroom under the mustard-color blanket that's come out of the closet to comfort us since before I can remember. I hear heavy, still quiet. I hear, almost imperceptibly, his beloved cat Lucy licking her paw. She's curled at the foot of the bed, keeping his feet warm, keeping watch. This is the sound of peace.
—Liz, @LizVacc, [email protected]
Thanks! You're on our list.
And your life's about to get more interesting.
Some people like to travel by train because it combines the slowness of a car with the cramped public exposure of an airplane.
Dennis Miller
I think my pilot was a little inexperienced. We were sitting on the runway, and he said, "OK, folks, we're gonna be taking off in a just few—whoa! Here we go."
Kevin Nealon
"I can't wait until your vacation is over." —Everyone following you on Instagram
A man knocked on my door and asked for a donation toward the local swimming pool. So I gave him a glass of water.
Comedian Greg Davies
Just found the worst page in the entire dictionary. What I saw was disgraceful, disgusting, dishonest, and disingenuous.
Client: We need you to log in to the YouTube and make all our company videos viral.
From clientsfromhell.net
My cat just walked up to the paper shredder and said, "Teach me everything you know."
"Just because you can't dance doesn't mean you shouldn't dance." —Alcohol
@yoyoha (Josh Hara)
My parents didn't want to move to Florida, but they turned 60 and that's the law.
—Jerry Seinfeld
Q: What do you call an Amish guy with his hand in a horse's mouth?
A: A mechanic.


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|Bauer Lightweight Warm-Up Team Pants Sr
Lowest Price Guarantee
The Bauer Lightweight Warm Up Pants are your classic hockey team warm-up pants. The Bauer Lightweight Warm Up Pants have replaced the Bauer Warm Up Pants, and will work as a replacement product for teams formerly using the Bauer Warm Up Pant.
- Model Numbers: 1039312, 1039314-16
- Bauer sizing guidelines:
Pant size / Waist / Player height (inches)
Small / 29-30" / 5'5"-5'9"
Medium / 31-33" / 5'9"-5'11"
Large / 34-35" / 5'11"-6'1"
- Materials:
- 100% Water-resistant polyester dobby construction
- Lightweight mesh lining with 3M™ Scotchgard™ Protector moisture wicking finish
- Lined from the knee up
- High quality YKK® zippers
- Design:
- Elastic waistband with drawstring tie
- Two side-slit "on-seam" pockets
- Zippered back pocket
- Lower leg zips for easy on/off
- Bottom zippers are set 2.5" above bottom leg opening
- Allows for easy alteration
- Embroidered Bauer logo on lower right leg
- Great team pant - Blank space allows room for a custom team logo
Click here for more information on a team purchase
Comments: Love these pants. As a coach, they are constantly getting hit with skate blades and velcro from bags and have proven to be extremely durable. They are warm and breathe well which makes them very comfortable while being lightweight. They do run a little long but are easy to adjust with the tie system on the waist. Highly recommend!
From: Dan, NJ
Comments: The pants are made of a material that's similar to the Bauer warm-up jackets. That's a good thing because they have a very "high quality" feel. They seem to keep warmth nicely with a soft material lining the upper portion of the pants.
I'm 6'4" and 195 lbs (36 waist) so getting pants that fit correctly isn't exactly easy. I bought the XL- they're a tad short but fit good enough. If they were another inch in length then they would be perfect. I plan on using them on the ice, however, so the pant length doesn't bother me too much since I'll be wearing skates.
From: Matt, Macomb, MI


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Symmetrized's Recent Activity
Looking to buy my first Hi-Fi Headphones - Help Please?
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The most well regarded headphones for under 150$
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Now offering FREE High-Speed Internet Access in ALL rooms. Located in the capital city of Louisiana, the La Quinta Inn-Baton Rouge Seigan Lane is close to all area attractions including the Blue Bayou Waterfront, the Old Louisiana State Capitol, all Louisiana State Government Offices, and Louisiana State University. Walk from here to a variety of great restaurants or head to nearby Boutin's Cajun Music & Dining. Mall of Louisiana is two miles.
Pet Policy
Pets stay FREE at La Quinta! Domestic pets, like cats and dogs, are welcome to stay at La Quinta. While rooms are spacious, no more than two (2) domestic pets are allowed per room. Be sure to keep your pets on a leash or in a carrier if they're outside your room. Pets may remain alone in a guestroom so long as the pet is well-behaved. With the exception of authorized service animals, pets are not allowed in the breakfast area, the fitness center and the laundry room or at the pool. If your cat is staying with you, you'll need to provide a litter box.
Features and Amenities
- Free Internet Access
- Free Breakfast
ReservationsBook Online or call 225-291-6600
Address & Contact:
10555 Reiger Rd
Baton Rouge, LA 70809
United States
10555 Reiger Rd
Baton Rouge, LA 70809
United States


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More Videos...
BMW S1000RR with stock swingarm beats drag car and runs a 8.75et in the 1/4 mile!
Dragbike Live was on location at the 2010 Citrus Nationals in West Palm Beach at Palm Beach International Raceway as history was made aboard the new BMW S1000RR. Jeremy Teasley riding for Brocks Performance ran an incredible 8.75 elapsed time at over 163 mph aboard a BMW S 1000 RR in Super Sport specs and thus beat a drag car too! Guys this is a stock swing arm on the bike!
2015 BMW S1000RR Quarter Mile Drag Race!
I take my 2015 S1000RR to the drag strip! Res Socks and Stickers! - http://tinyurl.com/o6je995 Keytags- http://tinyurl.com/ps3xyk9 MotoFrogger! - https://www.youtube.com/channel/UCgFUhJiNmcJL68jTOX1ahPQ https://www.facebook.com/RidingWithTom http://instagram.com/RidingWithTom https://twitter.com/RidingWithTom
Stretched Carbon Fiber BMW S1000RR
Super light all carbon fiber BMW S1000RR runs 9.0 in the 1/4 mile at Toronto Motorsports Park.
ZX10r vs BMW S1000rr - 1/4 Mile passes


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More Videos...
2012 Honda Accord EX-L V6, Fully Loaded with Navigation
My brand new 2012 Honda Accord, Ex-l V6, with navigation, chrome handles, leather interior, beige interior, sun roof, moon roof, automatic climate control, dual climate control, 19 inch wheels, white, white diamond, pearl, pearl white, luxury car, fast car, toyota, toyota camry, hyundai sonata, kia optima,
2012 Honda Accord EX-L V6 Review, Walk Around, Start Up & Rev, Interior
Rare top trim model with navigation. Still a great car, tho a tad too pricey in this top trim especially with the dated Navigation map and interface, really excited for the 2013 model. Its amazing how a fully loaded Kia Optima (which i would compare to this car) is about $31,400 similarly equipped. At that price, I would stick with the Honda, its just crazy how the Koreans used to be thousands cheaper and now they are asking for Japanese money (although, admittedly the Kia is much better looking than this Accord, but I would rather own and drive a Honda over a Kia today still)
2012 Honda Accord EX-L V6 NAVI Walkaround, Exhaust, Review and Test Drive
Final year of the 8th generation Honda Accord. Very much looking forward to what the 2013 Accord will be like when it comes out this fall. "The 2012 Honda Accord still has a lot going for it, but we think astute shoppers will find that several of its competitors are now more compelling." www.Edmunds.com
2012 Honda Accord Sedan Test Drive & Car Review
http://www.autobytel.com/honda/accord/2012/ The2012 Honda Accord Sedan lives in the most competitive car segment in the automotive world. Surrounded by midsized cars like the Toyota Camry, Nissan Altima, For Fusion, Hyundai Sonata, and more; the Accord has to shine in all areas. And year after year Honda continues to produce a car that lives up to its heritage. The 2012 Honda Accord is comfortable, well built, has excellent features, and it rides great. This midsized sedan does everything you want and more. The 2012 Honda Accord Sedan has a base price of $21,380 and the top of the line EX-L model cost $31,930. There are 21 different model/trim configurations between the sedan and coupe body styles. There are also 2 different engine choices. The first is a 2.4 liter 4-cylinder engine that makes 177 horsepower and 161 lb-ft. of torque. The other engine is a more powerful 3.5 liter V-6 that produces 271 horsepower and 254 lb-ft. of torque. Gas mileage for the smaller engine is 23 MPG in the city and 34 MPG on the highway and the larger V-6 engine gets 20 MPG in the city and 30 MPG on the highway. See More Car Videos http://www.autobytel.com/car-videos/ Join Our Facebook Page http://www.facebook.com/autobytel


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Showcase your love for this global sport with the Overhead Shot Of A Soccer Field wall mural from Eazywallz.com. This wallpaper photo brings the location of all the action into any room. The pleasant green color will liven up any walls, and makes this an ideal choice.
- Material: Peel & Stick Thin Canvas
- Finish: Matte
- Thickness:6.0 mil
No extra tools, glue, paste or water needed for hanging. This wall mural is removable, re-usable and will not damage your walls.
Eazy Wallz Inc. does not offer refunds on any product.
EazyWallz Inc. will offer an exchange for any incorrect, damaged and defective items within 30 days of the date of receipt. If you wish to return your item for an exchange, please contact our customer service by calling 1.877.631.EAZY or by email at firstname.lastname@example.com for a return authorization. Items must be returned in unused and intact condition in the original shipping package. We will pay the shipping costs.
Please allow 1 to 7 business days to process and print your order.
We ship almost everywhere in Canada and Contiguous United States via FedEx Ground. You will receive an email of confirmation when your item ships. FedEx Ground will have your order delivered within 1-10 business days depending on your location.
We now offer International shipping, outside of North America. Please contact us prior to your purchase in order to receive a shipping quote for your country.
We do not accept shipping addresses that are post office boxes.