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Start ups don't grow on trees. If you're looking to launch a successful company then you're probably going to be responsible for most of the growth yourself. But there is certainly more than one way you can raise the cash to get your business off the ground. Whether you already have a wealthy financier ready to inject cash into your project or need to secure money from more personal links, there are plenty of opportunities for funding. (more…)
Tag: small business funding
Starting a Business Debt-free: Benefits of Using 401(k) Business Financing
When it comes to small business financing options, it's usually traditional funding methods that come to mind: working capital loans, SBA loans, business lines of credit, etc. But did you know an alternative option exists that's allowed thousands of entrepreneurs to launch businesses debt-free? It's called a Rollover for Business Start-up (ROBS), and it enables you to leverage your own retirement assets to buy a business without having to pay any tax penalties or get a loan. (more…)
Your Small Business Finance Timeline
They say timing is everything, and nowhere is that phrase truer than in the world of small business — especially when it comes to business financing. If you're relying on some type of funding to get your business off the ground, your opening date is completely dependent on when you're able to secure start-up capital. So before you commit to a deadline, make sure your expectations are realistic by understanding the small business financing timeline: (more…)
Funding to Jumpstart Your Business Idea
For entrepreneurs in all stages of the business lifecycle, finding funding to jumpstart your business is an integral part of the journey. Not having access to enough capital can quickly derail even the most well laid-out plans, and it's a problem many entrepreneurs still face, in spite of improving consumer and business confidence. According to the Federal Reserve's Joint Small Business Credit Survey, 50 percent of small businesses received none of the financing they had applied for in the first half of 2014. (more…)
6 Tips for Creating a Great Business Plan
Whatever the aims for your business might be, there is a good chance that at some stage you will need to draw up a clear plan for its progress. The process of creating a business plan can be hard work but it serves a variety of important functions, especially when it comes to potentially attracting the financing that small companies so badly need in order to get started.
With that in mind, here are 6 tips for getting it right when it comes to building a great business plan. (more…)
ABCs of Small Business Industry: V is for Venture Capital
We're getting down to the bottom here at our small business industry series. Today's letter is 'V' is for venture capital!
First of all, what is venture capital?
Venture capital businesses give funding to early, high-potential, start up businesses. These businesses make their money by owning equity in the companies that they invest in, which usually have a novel technology or business model in high technology industries, like IT or biotechnology. The typical venture capital investment occurs after the seed funding round as the first round of institutional capital to fund growth in the interest of generating a return through an eventual realization event (like a trade sale of the company). (more…)
How Quick Business Loans Can Encourage Business Turnaround
If you need quick business loans to help you out of a short-term cash flow crisis, what you don't need is hassle when making these loan arrangements. We know all too well that any delay in making those funds available can lead to an operational headache, or threaten the survival of your business.
Reasons you may need a quick business loan
There could be an unexpected interruption in sales such as a delay in the delivery of stock that slows the flow of money coming into the business. It could be that you need quick business loans to pay for expensive new equipment or machinery in order to maintain production or cope with a sudden increase in demand. In difficult trading conditions, the customer has also become savvier, and more reluctant to make an immediate purchase, if they even make a purchase at all. As a result the retailer is late in paying you, the distributor. They, in turn, seek extended payment terms in order to assist their own cash flow. Suddenly, your usually strict 30 days terms of credit are being extended to 45 days or even 60 days. You will be paid, eventually, but later than you were expecting.
A short term business loan does not always have to be used to plug cash flow; it can be used as a tool to speed up business turnaround. Taking the right loan at the right time can be a great tactic to help you take advantage of business opportunities that come your way. The speed in which you can secure funding may determine how quickly you can push out in front of your competition or equally ensure your business does not plummet further into uncontrollable cash flow problems.
Go Against the Crowd: Friends & Family Funding Advice from TrustLeaf
Everyone has been talking about crowdfunding lately, but what about momfunding? Or friendfunding? Earlier this week, family loans site TrustLeaf released their first guide on "How to Borrow Money from Friends and Family." For any small business owner who's done this kind of loan before, the value of doing it right cannot be understated.
Unlike crowdfunding, where entrepreneurs ask for donations from strangers (sometimes with a gift in return) TrustLeaf helps small business owners raise money through their existing social and family network. "Crowdfunding is great if you have a sleek prototype or a chic new fashion line, but doesn't make as much sense for say, an auto repair shop." says Anson Liang, TrustLeaf's founder.
38% of all US small businesses start out with friends and family loans; on average, borrowing $25,000. Compare that with popular crowdfunding site Indiegogo, which only brings in about $1,000 on average per campaign. Kickstarter performs better, but the vast majority of campaigns raise less than $10,000, which in turn is less than half of friends and family loans on average.
How Fundable is Your Business?
Fund • a • bil • i • ty – [adj. Fuhnd-uh-bil-i-tee]
You won't find "Fundability" on Dictionary.com, so don't bother looking. Fundability is a phrase we've coined to describe how a business measures up in relation to the entire business lending and investing community.
All joking aside, how "Fundable" is your business?
Fundability is not just about your credit. It includes several components that determine how your overall business is seen by lenders, investors, insurers, suppliers, and more. Basically, we know that your business was worth the risk for you, but is it worth the risk for them?
5 Things to Know About Financing Your First Startup
By David Nilssen, Co-founder & CEO, Guidant Financial
If your goal for 2014 is to become a business owner, you're most likely being inundated with advice and tips. Maybe so much that sifting through it and evaluating who you can trust is eating up time that would be better spent putting the wheels in motion for your new venture. In the interest of saving you time and aggravation, I've broken down the five most important things you should know about getting the funds squared away for your business:
1) Pre-empt your lender's doubts.
If you're seeking a loan to purchase a franchise, your bank may be well-versed in franchising—or not. Assume they will need convincing about the franchise and do their homework for them: a risk evaluation using banking terminology and analyzing standard underwriting topics. A FRANdata bank credit report in hand will smooth your path with lenders.
2) Get your financial records in shape.
That means get them together in one place in a condition that makes it clear that you are trustworthy, keep meticulous records and are a serious professional. The bank is going to want to see:
- Personal and business credit history
- Personal and business financial statements for existing and startup businesses and as well as a projected financial statements
- A strong, detailed business plan (including personal information such as bios, education, etc.)
- Cash flow projections for at least a year
3) Realize that your payment history is important.
There's no question that your credit score is important, but banks will also look at your back payment history. If it concerns them, it could dilute the weight given even a strong credit score.
4) Make sure your resume reflects your business acumen.
Even if you've never owned a business before, highlight the experience you do have to show lenders that you have knowledge of the space you're entering, that you finish what you start, that you have membership in organizations that are relevant to your new business.
5) Keep calm and carry on.
It's become an internet meme, but it's relevant here. Be patient and move forward with plans as best you can while awaiting a decision from the lender. If you get a 'no,' move on. Successful business owners know that it's all about the long game.
Of course there are alternative ways to fund a business. If you've got a 401(k), there is a rather complex, but completely legal way to use the retirement account to purchase a business—without incurring any debt.
David Nilssen is the CEO & Co-Founder of Guidant Financial. Read more tips about becoming a successful entrepreneur in his book, Making the Jump into Small Business Ownership. He can be found on Twitter at @DavidNilssen.


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The overall objectives of this proposal are to improve our basic understanding of how dystroglycan binds laminin, and to explore the effectiveness of expressing LARGE and applying drugs of several classes in treating dystroglycan-related muscular dystrophies. In particular, the role of a novel post-translational phosphate modification?an O-linked mannose that is part of the laminin-binding glycan structure of alpha-dystroglycan?in laminin binding will be investigated. Also, new antibodies that recognize only immature alpha-DG with a terminal phosphate modification will be developed and used to evaluate the post-translational modification status of alpha-DG in tissues or cells collected from individuals with various types of dystroglycanopathies (by immunofluorescence, immunoblotting, and radioisotope-labeling). These studies will improve our understanding of the modifications required for dystroglycan to serve as a laminin receptor, and advance patient diagnosis by improving biomarker correlations with clinical severity. In vitro experiments with patient cells have suggested that overexpression of the glycosyltransferase LARGE can bypass alpha-dystroglycan glycosylation defects in a broad range of dystroglycanopathies. This hypothesis will be corroborated In vivo by assessing the ability to prevent disease in different dystroglycanopathy mouse models through either systemic or muscle-specific expression of the Large transgene. This will provide a better understanding of the feasibility and likelihood of success of broadly applying a LARGE-based therapy to the genetically diverse group of dystroglycanopathies. Furthermore, existing clinical drugs will be tested for their potential to ameliorate disease in dystroglycanopathy mouse models. The group of drugs to be tested includes a premature stop-codon readthrough drug (PTC124), as well as steroids (Prednisone) and PDES inhibitors (Sildenafil);the latter two compounds have already shown promise in the treatment of non-dystroglycan related muscular dystrophies. The effectiveness of these treatments will be explored using a combination of cell culture and in vivo mouse studies and measuring dystroglycan function, muscle physiology and pathology. The proposed research will provide a platform for new therapeutic avenues, some of which it will be possible to implement directly in the care of dystroglycanopathy patients
This project outline represents an opportunity to maximize the basic science expertise that contributes to the University of lowa MDCRC to achieve our goal of translating our research discoveries into clinical applications for the diagnosis and treatment of dystroglycan-related muscular dystrophy. Our basic science and translational approach on dystroglycanopathy mouse models will provide the groundwork for future clinical trials in dystroglycanopathy patients.
|Bönnemann, Carsten G; Wang, Ching H; Quijano-Roy, Susana et al. (2014) Diagnostic approach to the congenital muscular dystrophies. Neuromuscul Disord 24:289-311
|Inamori, Kei-ichiro; Willer, Tobias; Hara, Yuji et al. (2014) Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of ?-dystroglycan in cells and tissues. J Biol Chem 289:28138-48
|Chauveau, Claire; Bonnemann, Carsten G; Julien, Cedric et al. (2014) Recessive TTN truncating mutations define novel forms of core myopathy with heart disease. Hum Mol Genet 23:980-91
|Wallace, Stephanie E; Conta, Jessie H; Winder, Thomas L et al. (2014) A novel missense mutation in POMT1 modulates the severe congenital muscular dystrophy phenotype associated with POMT1 nonsense mutations. Neuromuscul Disord 24:312-20
|Willer, Tobias; Inamori, Kei-Ichiro; Venzke, David et al. (2014) The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated ?-dystroglycan functional glycosylation. Elife 3:
|Crockett, Cameron D; Ruggieri, Alessandra; Gujrati, Meena et al. (2014) Late adult-onset of X-linked myopathy with excessive autophagy. Muscle Nerve 50:138-44
|Goddeeris, Matthew M; Wu, Biming; Venzke, David et al. (2013) LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. Nature 503:136-40
|Cirak, Sebahattin; Foley, Aileen Reghan; Herrmann, Ralf et al. (2013) ISPD gene mutations are a common cause of congenital and limb-girdle muscular dystrophies. Brain 136:269-81
|Yang, Amy C; Ng, Bobby G; Moore, Steven A et al. (2013) Congenital disorder of glycosylation due to DPM1 mutations presenting with dystroglycanopathy-type congenital muscular dystrophy. Mol Genet Metab 110:345-51
|Stevens, Elizabeth; Carss, Keren J; Cirak, Sebahattin et al. (2013) Mutations in B3GALNT2 cause congenital muscular dystrophy and hypoglycosylation of *-dystroglycan. Am J Hum Genet 92:354-65
Showing the most recent 10 out of 47 publications

subset: commoncrawl


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Mars Hand Lens Imager (MAHLI)
Second only to the rock hammer, the hand lens is an essential tool of human geologists. Usually carried on a string around the person's neck, the hand lens helps a geologist in the field identify the minerals in a rock. The robotic geologist, Mars Science Laboratory, carries its own equivalent of the geologist's hand lens, the Mars Hand Lens Imager (MAHLI).
MAHLI will provide earthbound scientists with close-up views of the minerals, textures, and structures in martian rocks and the surface layer of rocky debris and dust. The self-focusing, roughly 4-centimeter-wide (1.5-inch-wide) camera will take color images of features as small as 12.5 micrometers, smaller than the diameter of a human hair. MAHLI carries both white light sources, similar to the light from a flashlight, and ultraviolet light sources, similar to the light from a tanning lamp, making the imager functional both day and night. The ultraviolet light will be used to induce fluorescence to help detect carbonate and evaporite minerals, both of which indicate that water helped shape the landscape on Mars.
MAHLI's main objective is to help the Mars Science Laboratory science team understand the geologic history of the landing site on Mars. MAHLI will also help researchers select samples for further investigation.
First Color Image of the Martian Landscape Returned from Curiosity
View of the landscape to the north of NASA's Mars rover Curiosity acquired by the Mars Hand Lens Imager (MAHLI) on the afternoon of the first day after landing
Calibration Target on Curiosity for Camera on Rover's Arm
The Mars Hand Lens Imager (MAHLI) camera at the end of the robotic arm of NASA's Curiosity rover will use a calibration target attached to a shoulder joint of the arm. Credit: NASA/JPL-Caltech


text: Recent stories about Derriford Hospital / RheumatologyRecent postings from Patient Opinion, the independent healthcare feedback sitehttps://www.patientopinion.org.uk/feed/opinions?nacs=RK950_410Patient Opinion, under Creative Commons Attribution-Noncommercial-No Derivative Works 3.02017-02-22T06:17:12Zhttps://www.patientopinion.org.uk/content/UK/1/images/logos/default_theme/po_header_logo_footer.gif/opinions/335370Disappointing lack of patient centered careStory from as 2016-12-31T12:43:27Z2017-02-22T06:17:12ZI was referred to this department following positive blood tests for certain antibodies that may answer why I have such tiring and debilitating symptoms. I am desperate to return to work but have had to take unpaid time off due to my symptoms. I felt the doctor I saw was treating me with an prejudiced opinion that I 'want a diagnosis and pills and to stay off work'. I felt like this because despite my positive tests from a year ago, (the appointment has taken that long), they said positive tests also be don't merit a diagnosis and the symptoms I gave them were dismissed. The doctor was not interested in photos of various rashes I have had, instead they said I should see a dermatologist etc etc . I wanted to have these conditions 'ruled out' not in because at least I can tell my employer I will soon be fit to return, but it felt like the doctor was ruling the conditions out because they treated me and my symptoms as nonsense and the same as 'most of the general population have these symptoms'. My review has been written because I want these doctors to understand that empathy and understanding is needed to be shown to us patients, not everyone 'wants time off work' and not everyone exaggerates their symptoms......please treat us with respect and how you would wish your loved one to be treated and remember why you entered into medicine.....to help patients improve their health and life, please. I felt totally dismissed and a time waster./opinions/94943Wonderful treatment from Plymouth Cardiac and Rheumatology teamsStory from sarah4132 as the patient2013-05-02T11:02:48Z2017-02-22T06:17:12Zsarah4132It all started in early September. My nightmare begins when I woke at 3am with a pain in my left arm and tight chest. I went down stairs thinking it was wind and I had hurt my arm so was jumping around the front room untillabout five in the morning. Then I relized it was not going away, and not wind. I went and woke my wife to be told it's only wind so jumping around some more before giving up and decided to go back to my poor sleeping wife to say I'm not right I'm going to phone for an ambulance which I did but then my wife came down to take over and phoned 999. Within 10 minutes I had help with the paramedics - within two days after having a stent and doing well in hospital was sent home, and thought all was well. Until 6weeks later when I tried to go back to work when both hands started to swell up causing me a lot of pain. After visits to the doctors he thought that it was gout in the hands. It got really bad and I phoned 999 again for help and ended up back in hospital again when they decided it was gout and told me to keep taking the pills. After about two months on different pills I managed to go back to work the week before Christmas. I lasted one week before I got home, had a bath, got in the bath then could not get out. I got a pain from hell in my groin - I was in so much pain. So we phoned 999 again and I ended up back in hospita. They did the tests and thought that I had Septic Arthitis in my hip joint. I was in so much pain I could not walk or do any thing for myself. Luckily I managed to get out for Christmas day - they sent me home Christmas eve but was still in pain, then my hands swelled up Christmas day. As I sat on the settee watching my hands swell up. After that me and the doctor found out what it was. I was given the wrong drugs and I now have rheumatoid arthritis as well as having had a heart attack all the time. I was in hospital at Derriford, the doctors and nurses were fantastic - I cannot fault them. I will get through this but I can not do it without their help and believe me, I have had alot of help from them. As part of the heart attack treatment, I attended cardiac rehabilitation classes with the NHS in Plymouth at the rugby ground - the nurses there have been wonderful again they really give you a sense of purpose. I never thought I would like it but its been fun and I went when the rheumatism let me and to come away feeling good about oneself. The nurses really help you to feel good about trying to get on and nothing is to much trouble for them - they have even said although I have finished the classes I could still phone for help if I needed it which is nice - I cannot thank them enough. That's the Plymouth cardiac rehabilitation classes at Brickfields Leisure Centre - keep up the good work./opinions/8386Finally, a diagnosis!Story from Lol as the patient2008-05-11T14:53:40Z2017-02-22T06:17:12ZLolI am a 54 yr old female and I moved to Cornwall from Oxfordshire 7yrs ago. After 30 years of suffering violent hemiplegic migraines, Raynaud's phenomenon, menopause at 32 & gangrenous appendix, (all of which had been treated as seperate incidents by my GPs up country) I developed a pronounced redness on both my cheeks and nose, fatigue to the point where I could not work - needing to sleep constantly, multi neurological symptoms, profuse sweating, abdominal & gastric pain, joint & muscle pain & weakness, photo-sensitivity, rash & flu like symptoms when exposed to sunlight & weight gain. My GP, Dr Dale Staff was absolutely marvellous & wasted no time in referring me to various consultants at Derriford hospital Plymouth. Thanks to the superb care from Mr Mohad-Nor, Consultant Neurologist I was admitted for 2 weeks in September last year, and my care was passed over to Dr Lindsay Robertson, Consultant Rheumatologist who, after many tests & medical history diagnosed Systemic Lupus Erythematosus & aPL (Hughes) syndrome. She started treatments for my illness and has continued to monitor me carefully. I have been to Derriford many many times since & would like to sincerely thank Dr Robertson for the patience & understanding she has shown to me since my diagnosis. It took my GP & two consultants at Derriford less than 9mths to diagnose & treat something which had gone undiagnosed & untreated for so many years! I am still struggling with the magnitude of symptoms of SLE but could not ask for better shared care.


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Spun off from bug 337744 comment 6, chrome URLs can syntactically wrap arbitrary protocols and confer chrome privs! some don't work, but wrapping them in jar: does.
Luckily we block web content from directly loading chrome URLs as content, but it would be pretty easy to get a fair number of people to copy or drag a "broken" link to the address bar to get at content they really wanted (download the latest movie or music, free pr0n, etc).
> chrome://global/content/http://www.google.com/ does *not* work, because
> of the channel-unwinding checks at
> But if remote content were loaded from a JAR file it would work, e.g.:
> chrome://global/content/jar:http://www.example.com/myjar.zip!/somefile
Created attachment 222076 [details]
zipped alert.html testcase
Load the testcase unprivileged as
Load the testcase with chrome privileges as
Assigning "moderate" severity because of the required user-interaction, but if someone discovered a way to bypass checkLoadURI and find a way for web content to load chrome this would be "critical".
Anyone know a better bugzilla component for the chrome registry code? The description for XP Miscellany says "COMPONENT RETIRED. Please do not file bugs here." But this isn't a XUL bug, nor does this code live in Networking although it is related to URL processing. The "Core" product does not support any other general category.
Mozilla 1.7 may not have this bug or it may be manifested differently (even ff 1.0.x may have different manifestations), because of the different revisions and forks of chrome registry code involved.
Created attachment 222099 [details] [diff] [review]
Make colon an illegal character
This should be pretty safe and simple. Darin, if you can review ASAP, we're thinking about respinning 188.8.131.52 for this.
Yeah, but FF2 definitely has this issue.
I can't seem to reproduce with that testcase in trunk Seamonkey, but I'm not sure whether that's just a matter of needing URI syntax tweaks or a genuine chrome registry difference.
Wouldn't that prevent the use of ':' in filenames too? Would it make more sense to error out if NS_NewURI on some substring succeeds, since that's the case we really care about as far as I can tell?
I believe colons aren't legal characters in windows filenames anyway, and I'm worried about performance and reentrancy issue having to call NS_NewURI all the time.
But don't chrome URLs support query and reference fragments? If we are going to restrict ':' then that should only apply to the file path. Isn't it possible that chrome apps are using "chrome://foo/bar.xul?x=y:z" for stuff?
> Isn't it possible that chrome apps are using "chrome://foo/bar.xul?x=y:z" for stuff?
Also, what about escaped colons. Do we need to worry about those too?
Created attachment 222149 [details] [diff] [review]
Use NS_NewURI
This uses NS_NewURI to check for absolute URIs. I still prefer the first version, but I understand the concern with query strings.
I'll also look at colon-checkin just the path (not sure which would be more efficient).
Created attachment 222154 [details] [diff] [review]
Use GetFilePath
I think that this is probably the most-correct. BTW, the documentation of .filePath, .directory in nsIURL.idl is incorrect.
Comment on attachment 222154 [details] [diff] [review]
Use GetFilePath
I think you should add some comments explaining why these checks
are necessary. In what way is nsIURL's documentation incorrect?
Fixed on trunk.
Fixed on 1.8 branch
This does not appear to be a problem in Firefox 1.0.x or the Mozilla 1.7 series. I caused this in bug 278534, where I changed nsChromeRegistry::ConvertChromeURL from using string manipulation to resolving against the baseuri.
perhaps we should verify that the URL resulting from URL resolution is still a chrome: URL?
Except it's not, it's typically a jar:file:/// url.
Comment on attachment 222154 [details] [diff] [review]
Use GetFilePath
unfortunately missed the 220.127.116.11 train by a couple weeks, and we didn't do a respin we could slip this into.
Comment on attachment 222154 [details] [diff] [review]
Use GetFilePath
We need to get this into 220.127.116.11
Comment on attachment 222154 [details] [diff] [review]
Use GetFilePath
approved for 1.8.0 branch, a=dveditz for drivers
Fixed on MOZILLA_1_8_0_BRANCH
v.fixed on 1.8.0 branch with Mozilla/5.0 (Macintosh; U; Intel Mac OS X; en-US;
rv:188.8.131.52) Gecko/20060626 Firefox/220.127.116.11, permission denied for alert testcase.


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More women are getting involved in entrepreneurship, but there is still a gender gap, writes Candida Brush. It may be possible to encourage more women to start companies by helping them view entrepreneurship as a worthy pursuit, she notes. "Further, we need to disseminate the stories of women entrepreneurs, and provide more role models of women entrepreneurs of all kinds," she writes.
Full Story:Forbes


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Constant Contact Integration Goodness
You can integrate Constant Contact newsletter list management, and archives in your webpage.
This is a 2 part process involving your constant contact address and links on your website. Go here: http://constantcontact.custhelp.com/cgi-bin/constantcontact.cfg/php/enduser/popup_adp.php?p_faqid=1641&p_created=1165429783 and send me the code generated.
Here is a lovely video to link to your archived newsletters. : http://www.constantcontact.com/display_media.jsp?id=13t This exciting video will show you how to generate code in your Constant Contact account that we can put into your site to create a nice archive page for your newsletters. We could also link directly to the individual newsletters, but is more ongoing work for you.


text:
- Home
- Garden Statues
- Orlandi Statuary
- Dedo Gargoyle Statue (9"H)
- Home
- Garden Statues
- Gargoyle Statues
- Dedo Gargoyle Statue (9"H)
Dedo Gargoyle Statue (9"H)
Dedo Gargoyle Statue (9"H)
Product Description
"Little Dedo" is a small gargoyle with pointy ears and human-like feet on the Notre Dame Cathedral. Crafted of Fiber Stone for a quality look that will withstand the elements. Fiber Stone is fiberglass with a mixture of sand and stones cast into the surface followed by a hand painted finish to give the appearance of aged stone. Since it is reinforced with a fiberglass backing, the statue remains light-weight and less fragile than concrete. Each item is finished by artists and is original artwork, therefore no two are identical. This is a made-to-order item; Please allow 4 weeks for delivery.
Available in five finishes:
- White Moss (white wash with hints of moss)(shown)
- Sandstone (yellow ocre with revealed earth tones)
- Verde (rich green with a brown wash)
- Cathedral White (white with a brown wash)
- Soot (black wash over natural stone)
- Dimensions: 9"H x 8"W x 9"D
- Weight: 5 lbs.


text:
Office of Adaptive Services
Florida Gulf Coast University
10501 FGCU Blvd. S.
Fort Myers, FL 33965
Wellness Building
Phone: 239-590-7956
Fax: 239-590-7975
Disability Care Center, an organization that helps disabled Americans apply and appeal for Social Security Disability benefits by providing information, resources, and customer service. Their mission is to assist the disabled community and now offer 2 new annual scholarships for college students who have a disabling condition or are majoring in special education.
webpage outlining the specific details of the scholarships: disabilitycarecenter.org/giving-back/scholarships/
Below is some information about the organization as well as a short description of the Disabled Student scholarship.
Website: disabilitycarecenter.org
Address: 2875 South Orange Ave #500 Orlando, FL 32806
Phone number: (888) 504-0035
Scholarship Email: email@example.com
Scholarship Information
Name of the scholarship: The Disabled Student Scholarship
Deadline: August 1st, 2016
Scholarship Amount: $500
Description: This scholarship program is for students who are suffering from a debilitating condition(s) while continuing their education at a college institution. The condition can be any medically diagnosed impairment (physical or mental) that interferes with everyday activities and quality of life.
Bottar Leone, PLLC, is proud to announce its first ever scholarship for students with physical or learning disabilities (the "Bottar Leone Scholarship"). This $2,500 scholarship will be awarded twice annually to a recent high school graduate with a documented physical or learning disability
Deadlines for Applications: July 1st for fall, December 1st for spring
The Springboard Foundation, which was created solely to provide scholarships to college students with disabilities: The 2016 application process is now open.
To learn more about the Foundation, the scholarships and the 2016 scholarship application process, please visit www.thespringboardfoundation.org
Purpose To fund post-high school educational opportunities at the college, community college, or technical
school level for men and women with a physical disability who use a wheelchair
Award The number of scholarships awarded each year and the amount of each is determined by the
Selection Committee. Students may reapply.
Eligibility Requirements
• Must have graduated from a public or private high school in Charlotte, Collier, Glades, Hendry or Lee
County; or currently be enrolled or planning to attend a Florida state college, community college or
technical school
• Must have a physical disability and use a wheelchair
• Must document financial need
Any student interested please go to to www.floridacommunity.com to complete the application. Once opened click on "I'm a Student".
There's an excellent app called Duolingo that is multi-platform that is being touted as the best way to learn a new language on the go. It's supposed to be easy, fun, and very effective.
And a link to the app's webpage: http://www.duolingo.com/
AudioNote for iPad and iPhone. It records the audio and syncs it with the typed content. Click on the link for more information:
This Virtual Career Fair is FREE for students and alumni with disabilities to attend.
Great opportunity for College students & College grads with disabilities to meet online with employers across the nation including Abbott, American Airlines, Booz Allen Hamilton, Capital One, FAA, PwC, Peace Corps, USDA, & More Great Employers!
Register at www.disability.careereco.net
Career Opportunities for Students with Disabilities
Centers for Independent Living
Disability and Business Technical Assistance
Job Accommodation Network
The Office of Disability Employment Policy
Plan to Achieve Self-Support
Rehabilitation Services Offices
Ticket to Work
Workforce Recruitment Program
disABLEDperson, Inc. announces new portal for college Grads with disabilities!
disABLEDperson, Inc. is a faith-based non-profit organization dedicated to helping people with disabilities find employment. This occurs through the www.disABLEDperson.com online recruitment program and through cooperative agreements with other mainstream employment services. We are proud to announce the addition of our new service for students with disabilities who have or are close to obtaining a college degree. We are working alongside employers to secure job postings for these graduates.
www.disABLEDperson.com/grads will launch September 15, 2009.
Diana Corso
Executive Director
disABLEDperson Inc.
http://www.loc.gov/nls/ (National Library Service for the Blind and Physically Handicapped)


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UFC light heavyweight Tom Lawlor is suspended for two years following a positive test for ostarine, the promotion's anti-doping partner USADA today confirmed.Filed under: News, UFC read news >>
USADA announced on Monday that UFC athlete Daniel Omielanczuk has tested positive for a prohibited substance, but found "without fault." read news >>
Mike Richman tested positive for steroids following a 2015 Bellator bout, and then he surprised the sport by breaking from the usual script with a frank admission: He did it, and he had no excuse. Fi read news >>
Nick Diaz and Snoop Dogg discuss the real issues. read news >>
Professional athletes wield more influence than some of them realize. They're heroes to an impressionable youth, but aren't always role models. read news >>
Flyweight Matheus Nicolau had just picked up his computer on a Thursday when he read an email he said felt like being hit by a bucket of cold water.Filed under: News, UFC read news >>
Photo by Jeff Bottari/Zuffa LLC A positive out-of-competition drug test was the reason UFC interim light heavyweight champion Jon Jones was pulled off the historic UFC 200 card back in July. He was s read news >>
The U.S. Anti-Doping Agency (USADA) officially suspended Jon Jones for one year Monday after he tested positive for two banned substances prior to his UFC 200 clash with Daniel Cormier in July, accor read news >>
UFC fighter Adam Hunter has received a two-year suspension after testing positive to multiple prohibited substances. read news >>
Adam Hunter's planned UFC debut was canceled due to a potential anti-doping violation. Now, it'll have to wait at least a few more years.Filed under: News, UFC read news >>
Jon Jones' attorney, Howard Jacobs, claimed his client's positive UFC 200 drug test result stemmed from a contaminated product. read news >>
It was rumored that asthma medication may have caused Brock Lesnar's positive tests at UFC 200, but the former UFC heavyweight champion has instead requested tests on both an eye medication and foot read news >>
Joao Zeferino has a surprisingly positive outlook on the current status of his career. With back-to-back losses, Zeferino said he doesn't feel an unordinary amount of pressure to get back on track wh read news >>
In his return, Chael Sonnen has to endure much tougher drug testing scrutiny. If he slips up, his contract imposes crippling financial repercussions. read news >>


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Music: Lovee to the song the makes you look at your volume and ask, "can this turn up louder"?
Photography,Why I love it (not just it's obvious beauty): I'm anxious to see and use all the different cameras available, and I want all the different types of cameras, only to be able to see the different view of the world and the beauty it has. To capture it so that others can see that beauty as well and be able to see the wonders of the earth and the expression of photography. Spreading the passion, the wonder, the magnificence, happiness, of the world, even sometimes capturing the pain of others so that they can share their pain.


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More Videos...
1970 Maverick Grabber
This is my friend Roger's 1970 Maverick Grabber that his Grandmother origially bought new. She was the only owner of this car and it still has the original interior, paint and dealer installed a/c. Originally had the straight 6 but now has a Stroked 347.
Maverick GT
um maverick muito 10
historia del maverick
historia de la restauracion completa del maverick del tio de abdiel


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There is growing evidence that alterations in gene expression contribute to the long-lasting effects of antipsychotic drugs on the brain. Project 4 contributes importantly to our understanding of the molecular actions of antipsychotic drugs by examining these phenomena at the chromatin level, and by thereby providing novel insight into the molecular basis of antipsychotic drug action. Project 4 will first characterize global changes in histone modifications induced by chronic antipsychotic drug exposure within striatal and prefrontal cortical regions of brain. Preliminary data, indicate that repeated haloperidol or clozapine administration increases levels of a repressive form of histone modification, methylation of Lys9 of histone H3, in these two regions. This effect is mediated via the upregulation of a particular Lys9-H3 methyltransferase, G9a. The proposed studies are aimed at characterizing the cell types within these regions where this drug-induced adaptation occurs and exploring its contribution to the behavioral actions of antipsychotic drugs in several rodent models. Using state-of-the-art chromatin methods, Project 4 will then identify the specific genes that show altered Lys9-H3 methylation, or alterations in other histone or DNA modifications, after chronic drug exposure. We also will study the role of two transcription factors, DeltaFosB and CREB, which are induced in striatal and prefrontal regions by antipsychotic drugs. This will include a cell type analysis of transcription factor regulation and altered binding to gene promoters genome-wide in response to drug exposure. By overlaying the results of these analyses with cell-type specific studies of mRNA expression in Projects 1 and 2, and biochemical studies in Project 3, we will identify antipsychotic drug targets with unique precision, and pursue a small number of targets for their functional role in antipsychotic drug action in our behavioral models. Finally, we will validate the regulation of histone modifications, transcription factors, and novel drug targets in postmortem tissue obtained from patients with schizophrenia. Together, these studies will advance our understanding of antipsychotic drug action, and provide novel approaches for the development of new drugs with improved efficacy and side effect profiles.
to public health: Schizophrenia is a debilitating psychiatric disorder affecting ~1 % of the population. New therapeutic treatments for schizophrenia are needed. Project 4 will contribute to a more complete understanding of the cellular and molecular actions of antipsychotic drugs through molecular studies of the actions of these drugs in specific populations of nerve cells.
|Snyder, Gretchen L; Vanover, Kimberly E; Zhu, Hongwen et al. (2015) Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission. Psychopharmacology (Berl) 232:605-21
|Nakajima, Miho; Görlich, Andreas; Heintz, Nathaniel (2014) Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons. Cell 159:295-305
|Dietz, David M; Kennedy, Pamela J; Sun, Haosheng et al. (2014) ýýFosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes. Neuropsychopharmacology 39:538-44
|Svenningsson, P; Berg, L; Matthews, D et al. (2014) Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram. Mol Psychiatry 19:962-4
|Meyer, Douglas A; Torres-Altoro, Melissa I; Tan, Zhenjun et al. (2014) Ischemic stroke injury is mediated by aberrant Cdk5. J Neurosci 34:8259-67
|Surmeier, D James; Graves, Steven M; Shen, Weixing (2014) Dopaminergic modulation of striatal networks in health and Parkinson's disease. Curr Opin Neurobiol 29:109-17
|Heiman, Myriam; Kulicke, Ruth; Fenster, Robert J et al. (2014) Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP). Nat Protoc 9:1282-91
|Oh, Yong-Seok; Gao, Pu; Lee, Ko-Woon et al. (2013) SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell 152:831-43
|Nestler, Eric J (2013) Treating the brain deep down: Brain surgery for anorexia nervosa? Nat Med 19:678-9
|Svenningsson, Per; Kim, Yong; Warner-Schmidt, Jennifer et al. (2013) p11 and its role in depression and therapeutic responses to antidepressants. Nat Rev Neurosci 14:673-80
Showing the most recent 10 out of 20 publications


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The court allowed in part a claim for infringement of copyright in certain computer programs which formed part of a bond-broking system, and for breach of confidence in relation to those programs.
The plaintiffs ("CFI") and the first and second defendants ("Tradition") carried on business as inter-dealer brokers ("IDB") in bonds in London. An IDB facilitated trading between clients who wished to sell or to purchase financial instruments.
Mr Howard, the third defendant, was effectively dismissed by CFI. On his dismissal he cast around for employment and met Mr Adler, who was effectively in control of Tradition. Mr Howard proposed that he should set up an IDB business for Tradition in London. He recruited Mr Harland, the fourth defendant, then head of the systems department at CFI.
Roger Wyand QC and Robert Onslow (Norton Rose) for the plaintiffs; Peter Prescott QC and James Mellor (Wilde Sapte) for the first, second and fourth defendants; George Hamer (Warner Cranston) for the third defendant.
Mr Justice Pumfrey said that copyright protection was conferred on computer programs as literary works. In Ibcos Computers Ltd v Barclays Mercantile Highland Finance Ltd [1994] FSR 275, Jacob J had said that a claim in copyright was to be tested as follows: what was the work or works in which the plaintiff claimed copyright?; was each such work original?; had there been copying from that work?; and, if there had been copying, had a substantial part of that work been reproduced?
There was however, a real risk of making an error if the court adapted well-known principles which had been developed in the context of literary works addressed to humans, and applied them uncritically to literary works whose only purpose was to make a machine operate in a certain manner.
In the present case, the interrelationship of the originality of the work (the prerequisite for the subsistence of copyright) and substantiality of the part of the work copied (the prerequisite for infringement) was of considerable importance.
So far as English law was concerned the correct approach to substantiality was straightforward. It was the function of copyright to protect the relevant skill and labour expended by the author of the work. It followed that a copyist infringed if he appropriated a part of the work upon which a substantial part of the author's skill and labour had been expended.
The statement of principle in Catnic Components v Hill & Smith [1982] RPC 182, at 223, could not be applied directly to infringement of literary copyrights in general or literary copyrights subsisting in computer programs in particular, but it none the less reflected the approach the court considered appropriate.
In the general case, it was well established that a substantial part of the author's skill and labour resided in the plot of a novel or a play, and that to take that plot without taking any part of the particular manner of its expression might be sufficient to amount to copyright infringement.
The closest analogy to a plot in a computer program lay in the algorithms or sequences of operations decided on by the programmer to achieve his object. Moreover, it was generally accepted that the "architecture" of a computer program was capable of protection if a substantial part of the programmer's skill, labour and judgement had gone into it.
Applying that approach to the present case, the allegations of infringement of copyright and breach of confidence succeeded in part: the claims against Mr Howard and Mr Harland as joint tortfeasers succeeded, Tradition's claim for an indemnity against Mr Howard succeeded, and Mr Howard's claim for an indemnity failed.Reuse content


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Lap up the Dog's Brew
From Moondoggies to premiere beer destination
Chad Deal 5 p.m., Feb. 22
Trinity Theatre presents Mitch Albom's comedy about a movie star, nominated for an Oscar, who dies the night before the awards. Elizabeth Greene and Larry Fox co-direct.
1531 Tyler Avenue, San Diego, 92103
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Develop an ethical hacker mindset to test the best Network security products. In this role, you will be working with the Content QA team working on the latest...
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Penetration Tester / Ethical Hacker:. New Penetration Tester / Ethical Hacker full-time employee position in Dallas, TX....
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Common web application security issues, Active Directory, exploitation frameworks (such as Metasploit, etc.),....


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Whether you're looking to personalize learning for better outcomes or empower your students with problem solving skills, sourcing the right software and content—with guidance from the Intel® Edtech solutions framework—is critical for student success.
From helping at-risk students with immersive content to simplifying administrators' distribution of it, Intel® Education Study is the right solution for putting engaging digital content and student-educator interaction at the center of learning.
With enhanced content that increases engagement, comprehension, and retention, the Intel® Education Study App helps students make more efficient use of their study time.
Streamline digital content deployments, organize student data, and manage content distribution, all while saving time with the easy-to-use Intel® Education Study: Administer.
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Immerse students in interactive learning with Intel® Education Study: School Publisher—an enhancement tool for modifying curriculum through simple creation and distribution of enhanced eTextbooks.
Intel® Education IT advisors work with you to solve IT challenges in education.
Intel® Education delivers a comprehensive approach to creating successful learning environments. By developing a strategic plan that supports your education vision, you can build a robust infrastructure, choose the right devices, and source the best software for your needs—all keys to driving a holistic solution for student success.
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Come back in February for a review of the 200th Anniversary celebration events and actvities
In 2016, this area of eastern Ontario will mark its 200th Anniversary - and preparations are underway to deliver a major celebration! As we move into 2016, this section of our website will provide links to the partner organisations involved in the celebration, as they develop and stage their events. See the sidebar menu to connect to these organisations.
Organising committees have been appointed for the Town of Perth, Tay Valley Township, and Drummond/North Elmsley Township. Further east, the Beckwith Township Heritage Committee will also be presenting anniversary events.
The 200th anniversary will mark the arrival of the first European settlers and War of 1812 veterans to this area. It will also celebrate the building of our communities through these 200 years, in the four municipalities. The celebration will honor our forebears, recognize their achievements, pay tribute to the First Nations, and commemorate this significant and enduring history through activities and events in these municipalities leading up to and during 2016. The celebration will, in particular, highlight the original historic municipalities of Perth, Bathurst, North Burgess, South Sherbrooke, Drummond, North Elmsley and Beckwith.
In March 2015, our historical society provided an early launch for the 200th Anniversary with the presentation, to each of the four municipalities, of a traditionally styled lantern, recognising the essential role that lanterns played in early settlement life. The lanterns also provide a means for member Councils to symbolically welcome the anniversary in 2016.
For a detailed history of the founding of this area, click here.
For a listing of important dates leading up to and during the founding of the Perth Military Settlement click here.
Historical Mapping Project
Use the links below to find the names and locations of the earliest military personnel and settlers:
Perth Military Settlement Map - zoom in and place your cursor on any Lot to view the data.
Searchable Database: use the magnifying glass icon and enter family or transport ship names. Use the map icon for a map view.


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St. Jude Children's Research Hospital has been named one of the best cancer care hospitals in the country by Parents magazine. The results, based on the magazine's survey of more than 60 children's hospitals, appear in the March 2013 issue.
"Being recognized is always a great honor, especially since our focus on some of the toughest pediatric cancers often makes comparisons difficult," said Dr. William E. Evans, St. Jude director and CEO. "This recognition is a tribute to the tireless dedication of all of our physicians, researchers and staff who help families facing the most challenging times imaginable."
Based on published research data, St. Jude has the best worldwide outcomes in a number of pediatric cancer categories, including acute lymphoblastic leukemia, acute myeloid leukemia and medulloblastoma. "Our strategic plan focuses our efforts on two ambitious goals: improving pediatric cancer cure rates and improving long-term quality of life for survivors," Evans said.
St. Jude was ranked No. 2 in the cancer care hospital category. "Among our points of pride are the depth of the comprehensive care we provide and the highest nurse-to-patient ratio in the nation," said Joseph Laver, M.D., St. Jude clinical director and executive vice president. "But, perhaps most meaningful to our patient care staff is the high satisfaction of our patient families." St. Jude's patient satisfaction scores exceed national averages, with the hospital earning a perfect 100 percent overall satisfaction rating for its outpatient services in the most recent NRC Picker survey.
"These families are our inspiration, and we work hard to engage them in our everyday discussions on how to enhance their experiences," Laver said.
The hospitals on the list were ranked based on their voluntary responses to a set of detailed questions regarding survival rates, experience in performing complex procedures, research programs, safeguards to prevent medical errors, staffing ratios and quality, community outreach and services that address the emotional needs of patients' families.
The magazine also chose the top children's hospitals for orthopedic care, pulmonary care, heart care, preemie care and emergency care. A complete list of the best children's hospitals by specialty can be found at www.parentsmag.com.
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital is leading the way the world understands, treats and cures childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20 percent to 80 percent since the hospital opened more than 50 years ago. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill from St. Jude for treatment, travel, housing and food — because all a family should worry about is helping their child live. To learn more, visit stjude.org or follow the hospital on Twitter and Instagram at @stjuderesearch.
St. Jude Media Relations Contact
Jann Ingmire
Desk: (901) 595-6384
Cell: (901) 356-5716


text: Bear Trapped In Shopping Mall. Uploaded 07/23/2012 He just came to get some bear necessities. He bearly posed any risk to the public and they quickly darted him off to bearback mountain. Share Video REPLAY VIDEO Bear Trapped In Shopping Mall. NEXT VIDEO The GARLIC Challenge (Eat An Entire Garlic w/peeling) RELATED MEDIA Bear Dismantles Electric Trap Like A Boss Heavy Rains Turn This Chinese Shopping Mall Into A Water Park Jimmy's Costume Shop This Girl Can Sing, But Wait.... Little Girl Swims In Mall's Koi Pond Teen Rescued on Artic Ice A Mall's Shark Tank Explodes In Front Of Spectators San Francisco Cop Gets Hit By Barricade Take a Look at This Grizly Bear Cub Playing With Wolf Cub! Sex In The Mall Mall Prank Mall Accident Mall Prank Mall Fun Mall Prank Girl Falls in Mall Fountain While Texting Mall Santa Fail Having Fun At The Mall Mentos And Coke Trap Autoplay On Next Video Share Tweet Stumble Email Pin It Embed: Use old embed code Use new embed code Tags: bear trapped shopping mall NEXT VIDEO The GARLIC Challenge (Eat An Entire Garlic w/peeling) 0 Comments Login to Comment


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Added to Cart
Estee Lauder Beyond Paradise Eau De Parfume Spray (50ml/1.7oz)
Estee Lauder Beyond Paradise Eau De Parfume Spray (50ml/1.7oz)
A tempting fragrance
Embraces your skin with a blend of tropical wetness, freshness & floral scent
Gives you a rich sense of fantasy
Top notes: Eden's Mist, Blue Hyacinth, Orange Flower Templar, Jabuticaba FruitMiddle notes: Laelia Orchid, Crepe Jasmin, Mahonia Japonica, Pink Honeysuckle
Base notes: Natal Plum Blossoms, Ambrette Seed, Zebrano Wood, Golden Melaleuca Bark
Due to the nature of this product, we are unable to accept a return under the terms of our Returns Policy for 'change of mind' purposes or sizing errors.
Returns for these products will only be accepted where the goods are deemed faulty under the terms of our Warranty Terms & Conditions .
This Product is offered and supplied by Kogan HK Limited pursuant to the Terms and Conditions.
Related CategoriesHealth & Beauty - Bundle & Save!Health & Beauty - Deodorants & Anti-Perspirants Health & Beauty - Eye, Ear & Nose CareHealth & Beauty - Fitness EquipmentHealth & Beauty - FragrancesHealth & Beauty - Grooming & ShavingHealth & Beauty - HaircareHealth & Beauty - Hair CareHealth & Beauty - Hair Dryers & StylersHealth & Beauty - Jewellery CleanersHealth & Beauty - Kids' FragranceHealth & Beauty - Makeup & CosmeticsHealth & Beauty - Massage & RelaxationHealth & Beauty - Medical & First AidHealth & Beauty - Men's SkinOral CarePharmaceuticalsScales (Bathroom)Shampoo & ConditionersSkincareSoapSunscreen & RepellantsVitamins & SupplementsWomen's Fragrance


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They don't these are much smaller than ear bud size The CKM300 have even smaller drivers so they should be even more comfy. Even though the CKM500 has some bigger 12.5mm drivers the housing is streamlined and smooth. Very comfy for normal to larger ears and I am willing to bet even smaller ears while you will certainly know it is there, should have no issues.
Edited by Dsnuts - 6/10/12 at 11:05am


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"Glee" [1] has tipped its hat to Broadway, Lady Gaga [2] and classic rock including its recent Fleetwood Mac [3]-inspired episode, so why would the Fox dramedy, whose goal is to stress the importance of music education and appreciation, cover Rebecca Black's much-maligned "Friday" [4]?
'Glee' to Cover Rebecca Black's 'Friday' [4]
"There's a rule for it that's explained in the show," "Glee" co-creator Ryan Murphy told The Hollywood Reporter. "The [glee club] is hired to perform songs for the prom and they were told by the principal to please do popular songs that the kids know."
Black's heavily Auto-Tuned song became an Internet sensation for all the wrong reasons and landed its 13-year-old singer death threats. The YouTube clip has garnered more than 133 million views.
Murphy noted that "Glee's" "Friday" cover -- performed by Puck (Mark Salling), Artie (Kevin McHale) and Sam (Chord Overstreet) -- offers a different take since it's performed by males.
'Glee' Spreads Fleetwood Mac's 'Rumours' [5]
"It's songs that supposedly 17-year-olds are performing for other 17-year-olds," he noted. "I think younger kids have a definite reaction to that song."
He added, "The show pays tribute to pop culture and, love it or hate it, that song is pop culture."
"Glee's" prom episode airs Tuesday (May 10) on Fox.
- News [6]


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SOURCE Harwood Feffer LLP
SOURCE Harwood Feffer LLP
The point-and-figure chart indicates upside potential of $174, perhaps even higher.
Jim Cramer explains how bullish comments from one semiconductor equipment maker lifts shares throughout the sector.
Amid all the pre-inaugural craziness, it's comforting to know market moves aren't random.
Qualcomm is being sued by the Federal Trade Commission for allegedly unfair practices in licensing its technology.


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Vertebrate cells employ a litany of non-coding RNAs (ncRNAs) to orchestrate and regulate the synthesis of proteins. In addition to the transfer RNAs and ribosomal RNAs that decode messenger RNAs in the cytoplasm, ncRNAs are involved in the earliest steps of gene expression in the nucleus: long ncRNAs modulate chromatin structure and thus transcription, while two sets of small nuclear RNAs (snRNAs) are the building blocks of the major and minor spliceosomes that remove both constitutively- and alternatively-spliced introns from pre- mRNAs. Even the 32-end formation of histone mRNAs requires the U7 snRNA. These essential ncRNAs themselves undergo covalent modification directed by yet other classes of ncRNAs during their biogenesis in the nucleus: small nucleolar RNAs (snoRNAs) and small Cajal body RNAs (scaRNAs) guide the specific introduction of 22-O-methyl and pseudoU residues into rRNAs and snRNAs, respectively. Once exported to the cytoplasm, mRNA translation and stability are regulated by microRNAs, the newest class of ncRNAs, which undergo regulated processing steps in both the nucleus and the cytoplasm during their biogenesis. All of these ncRNAs act in conjunction with bound proteins, forming ncRNPs, to execute their functions. The proposed research will continue to discover novel ncRNP functions and protein interactions that underlie the biogenesis and stability of ncRNAs, particularly in the vertebrate cell nucleus. Specifically, a novel chaperone function for a scaRNA in assembling the U2 snRNP will be investigated. Our discovery that the core RNA helicase component (eIF4AIII) of the exon junction complex has a second conserved role in ribosomal RNA biogenesis will be confirmed. The probable existence of additional eIF4A/eIF4G-like pairs will be explored and their contributions to critical steps in gene expression assigned. Phosphoproteomics and single-molecule approaches will complement functional studies of the core components of the Microprocessor-Drosha and DGCR8-to uncover the molecular basis of regulation of pri-microRNA processing in the nucleus of tumorigenic versus non-tumorigenic cells. RNA elements that confer stability on nuclear long noncoding RNAs will be identified bioinformatically and characterized both biochemically and structurally. Nucleases participating in rapid RNA decay in the nucleus will be identified, and their possible localization in nuclear bodies will be investigated using single-molecule live-cell imaging techniques. Together, this understanding will contribute to the development of therapeutic approaches to combat multiple genetic diseases that derive from faulty RNA processing and surveillance, as well as cancer.
Some RNA molecules do not serve as messages for making proteins but nonetheless play essential roles in the production of the cell's repertoire of proteins. Recently, additional kinds and novel functions of such noncoding RNAs have been recognized, underscoring their importance in regulating the production of cellular proteins. Our exploration of the contributions of noncoding RNAs will provide novel insights into potential targets and therapeutic mechanisms for combating a multitude of devastating genetic diseases including muscular dystrophy, spinal muscular atrophy and cancer.
|Brown, Jessica A; Bulkley, David; Wang, Jimin et al. (2014) Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix. Nat Struct Mol Biol 21:633-40
|Cech, Thomas R; Steitz, Joan A (2014) The noncoding RNA revolution-trashing old rules to forge new ones. Cell 157:77-94
|Xie, Mingyi; Steitz, Joan A (2014) Versatile microRNA biogenesis in animals and their viruses. RNA Biol 11:673-81
|Riley, Kasandra J; Steitz, Joan A (2013) The "Observer Effect" in genome-wide surveys of protein-RNA interactions. Mol Cell 49:601-4
|Herbert, Kristina M; Pimienta, Genaro; DeGregorio, Suzanne J et al. (2013) Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile. Cell Rep 5:1070-81
|Alexandrov, Andrei; Colognori, David; Steitz, Joan A (2011) Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex. Genes Dev 25:1078-90
|Mortensen, Richard D; Serra, Maria; Steitz, Joan A et al. (2011) Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs). Proc Natl Acad Sci U S A 108:8281-6
|Pawlicki, Jan M; Steitz, Joan A (2010) Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function. Trends Cell Biol 20:52-61
|Borah, Sumit; Wong, Anthony C; Steitz, Joan A (2009) Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron. Proc Natl Acad Sci U S A 106:2577-82
|Tycowski, Kazimierz T; Shu, Mei-Di; Kukoyi, Abiodun et al. (2009) A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. Mol Cell 34:47-57
Showing the most recent 10 out of 115 publications


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We are committed to our valued customer base of certified Value Added Resellers (VARs). Authorized by the end user, VARs have access to around-the-clock technical support and diagnostic services. That means you can serve customers in the areas of technical repair and installation and provide upgrades to existing products and systems through this network of qualified resources around the globe.
Technical Support & RMA assistance for Professional Security products can be obtained by phone, e-mail, or chat around the globe:
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To contact our Global Support team by phone for assistance with any of the products above, dial the phone number for your Region found below. Note, a valid Software Service Agreement (SSA) is required to receive phone support for our Latitude, Horizon & Meridian software platforms. Platinum level customers are entitled to 24/7 support.
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Which actors are coming back for Season 3 of #AmericanCrime? https://t.co/GjU3F1Ta1s pic.twitter.com/WY8UFkNYpJ
— TV Guide (@TVGuide) June 29, 2016
Hurray!! #AmericanCrime gets another year! Can't wait to hear what John Ridley has in-store for us! https://t.co/iUROfRnKDh @AmericanCrimeTV
— Felicity Huffman (@FelicityHuffman) May 13, 2016
Sony Pictures Home Entertainment is bring their award-winning drama, Stealing Cars, to DVD. Before the official release date, take a peek ensemble drama starring Mike Epps (The Hangover), Felicity Huffman (American Crime), William H. Macy (Shamless) and John Leguizamo (John Wick).
Taking home the the Zeitgeist Award at the 2015 Los Angeles Film Festival, the critically acclaimed drama comes from Rachel Winter, a producer of Dallas Buyers Club, and executive producers Mark Wahlberg and Stephen Levinson (Entourage). Winter had been in development of the project since the mid-1990s before finally getting the film going into production. She first read the Stealing Cars script by Will Aldis and Steve Mackall back in 1999.
According to the official plot synopsis, Billy Wyatt (Emory Cohen) is a young man with tremendous promise. A tragic car accident sends the confident yet rebellious teen spiraling downward into the juvenile penal system, His troubled past unfortunately leads Billy straight to the Bernville Camp for Boys. Inside the camp, Billy must navigate his way through dangerous inmates, while dealing with a cruel and equally punishing staff. During his incarceration, Billy learns to inspire others and find out the truth about himself in the process.
Balancing work and motherhood isn't always easy — even if you're an award-winning actress like Felicity Huffman.
"First, I have to recognize how lucky I am to have to navigate these sorts of issues. I have a job that I love and a fabulous family that I love," says Huffman, who is featured in the current issue of PEOPLE.
"But people always ask, 'How do you balance home life and work?' And I tell them, 'I don't. I just drop the ball all the time.'
Felicity Huffman, star of John Ridley's ABC anthology series American Crime, is guest starring in Ridley's ABC drama pilot Presence. The gig, limited to the pilot only, stems from Huffman's relationship with Ridley and fellow Presence executive producer Michael McDonald, who also exec produce Presence, and is the type of favor name actors do for writers and producers they have a strong relationship with. Huffman tweeted about her stint yesterday.
Shooting on location away from home has it's challenges for Felicity Huffman. But if her ABC drama American Crime couldn't be filmed in Los Angeles, she's glad it's shooting in Austin.
"It's a great city," says the actress, who is featured in the current issue of PEOPLE. "The people there are so kind and polite and outgoing and friendly. I love working there."
This is the second season the anthology series has shot in the capital of Texas, which has given Huffman, 52, plenty of time to explore the city.
Viewers we're surprised last year on "American Crime" when you played a woman with bigoted views. Now you're portraying a woman who is more pleasant on the surface but is more cunning and dangerous. What was your response when John Ridley first talked to you about her?
I was pleased. As we were building Leslie, I said to John, "She wants to be someone that people are drawn to." Men find her attractive, but women don't find her threatening. They go, "I like her skirt, I like her hair." She wins people over. She's such a chess player and a mastermind, a politician.
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Dr. Kaylakie attended dental school at Fairleigh Dickinson University, Hackensack, New Jersey. He served nine and a half years in the United States Air Forces. His prosthodontics specialty residency was at the University of Texas Health Science Center in San Antonio. This was completed in 1981 with a post-doctoral master's degree in Prosthodontics and Biomaterials. Dr. Kaylakie was then stationed at Bergstrom Air Force Base and moved to Austin, Texas. After leaving the Air Force in 1986, he established this current private practice here in Austin where he resides with his family. In his spare time, Dr. Kaylakie enjoys spending time with his wife, kids, grandchildren, and dogs from Heart of Texas Lab Rescue. He also likes playing the guitar and lute, as well as painting, drawing and wood crafting. When he has free time, Dr. Kaylakie loves to kayak on Lake Austin with his wife.Read more
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Original image data dated on or about July 1, 1997.
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