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|Chemistry: electrical and wave energy patents - Monitor Patents
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Chemistry: electrical and wave energy November recently filed with US Patent Office 11/09Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 11/26/2009 > 13 patent applications in 12 patent subcategories.
20090288941 - Photocatalytic air purifier for a fan coil unit: A photocatalytic air purifier is disclosed. The photocatalytic purifier includes filter structures coated with a catalytic material such as titanium dioxide. One or more UV lamps are interposed between the filter structures. The catalytic layer reacts with airborne VOCs and bioaerosols when activated by the UV lamps to thereby oxidize... Agent: Marjama Muldoon Blasiak & Sullivan LLP
20090288942 - Particulate capture in a plasma tool: A method and apparatus for increasing adhesion of particles ejected from a substrate being sputtered to interior surfaces of a vacuum chamber containing the substrate. The method includes: forming a viscous coating on a at least some regions of interior surfaces of the vacuum chamber, the viscous coating having a... Agent: Schmeiser, Olsen & Watts
20090288944 - Sputtering apparatus and method of manufacturing solar battery and image display device by using the same: A sputtering apparatus of a continuous system that a first target 17a and a second target 17b are arranged to obliquely face a substrate 6 and other targets to form a film while conveying the substrate 6 along a conveying path 15, wherein shields 19a, 19b facing the conveying direction... Agent: Fitzpatrick Cella Harper & Scinto
20090288943 - Thin film batteries and methods for manufacturing same: A method of fabricating a layer of a thin film battery comprises providing a sputtering target and depositing the layer on a substrate using a physical vapor deposition process enhanced by a combination of plasma processes. The deposition process may include: (1) generation of a plasma between the target and... Agent: Applied Materials C/o Pillsbury Winthrop Shaw Pittman LLP
20090288945 - Electroactivated film with electrocatalyst-enhanced carbon electrode: An electroactivated film that includes: a first electrode that is spaced apart from a second electrode, a water insoluble electrically conductive medium which is permeable to moisture and oxygen and which contacts both electrodes, an electrocatalyst which can be reversibly oxidized and reduced and which facilitates the production of a... Agent: Nelson Mullins Riley & Scarborough, LLP
20090288946 - Electroactivated film with layered structure: An electroactivated film that includes: a first electrode that is spaced apart from a second electrode, a water insoluble electrically conductive medium which is permeable to moisture and oxygen and which contacts both electrodes, an electrocatalyst which can be reversibly oxidized and reduced and which facilitates the production of a... Agent: Nelson Mullins Riley & Scarborough, LLP
20090288947 - Hydrogen generator system: A hydrogen generator apparatus for a vehicle a reservoir for electrolyte, and electrolyte chamber, an electrolyte feed line to the electrolyte chamber, at least one pair of electrodes chamber, a conduit from the electrolyte chamber to the air line of the engine, the electrodes being vertically disposed in the electrolyte... Agent: Young & Thompson
20090288948 - Physical vapor deposition apparatus: A physical vapor deposition apparatus includes a vacuum chamber, a particles producing means, a substrate stand, a correction plate, and an ion source disposed in the vacuum chamber. The physical vapor deposition apparatus further includes a strain gauge adhered on the correction plate for detecting deforming of the correction plate,... Agent: PCe Industry, Inc. Att. Steven Reiss
20090288949 - Reference electrode including electrolyte containing optically-active material and automatic electrochemical potential correction apparatus using the same: Disclosed herein is a reference electrode including an electrolyte containing an optically-active material, including: an electrode body provided at an end thereof with an electrolyte separation membrane and charged therein with an optically-active material and an electrolyte solution; an inner electrode disposed in the electrode body to be immersed in... Agent: Intellectual Property Group Fredrikson & Byron, P.A.
20090288950 - Liquid electro-mechanical prime mover: A liquid prime mover is provided that includes a support member for holding a contiguous liquid entity (e.g. a water droplet) having a defined dimension "d". An ion permeable exchange membrane is mounted on the support member. Also, a positive electrode and a negative electrode are mounted on the support... Agent: Nydegger & Associates
20090288951 - Method for automated high throughput identification of carbohydrates and carbohydrate mixture composition patterns as well as systems therefore: The present invention relates to methods for the identification of compounds in carbohydrate mixture compositions as well as the determination of carbohydrate mixture composition patterns, based on e.g. orthogonal cross determining migration time (indices) using capillary gel electrophoresis-laser induced fluorescence and identifying said carbohydrate components based on comparing said migration... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20090288952 - Hybrid slip casting-electrophoretic deposition (epd) process: The invention provides novel a hybrid slip casting-Electrophoretic Deposition (EPD) process which can be used to produce arbitrary shape geometries with controlled materials properties. The invention provides processes for the fabrication of Functionally Graded Materials (FGM) by a controlled Electrophoretic Deposition (EPD).... Agent: Morrison & Foerster LLP
20090288953 - Apparatus and method of using porous material for antigen separation, identification, and quantification with electrophoresis techniques: An apparatus includes a porous membrane for retaining antigens from a sample as the sample passes through the membrane. The apparatus also includes a first binding region within the membrane. The first binding region includes antibodies associated with a first antigen of interest. At least some of the antigens retained... Agent: Kris T. Fredrick Honeywell International Inc.11/19/2009 > 13 patent applications in 12 patent subcategories.
20090283399 - Ozone generating apparatus: An ozone generating apparatus is provided which includes a pair of electrodes for producing a discharge by the application of an ac voltage therebetween, and at least one dielectric provided between the pair of electrodes. A source gas containing oxygen is provided into a discharge space in which the discharge... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090283400 - Microwave-assisted rotatable pvd: Disclosed invention uses a coaxial microwave antenna to enhance ionization in PVD or IPVD. The coaxial microwave antenna increases plasma density homogeneously adjacent to a sputtering cathode or target that is subjected to a power supply. The coaxial microwave source generates electromagnetic waves in a transverse electromagnetic (TEM) mode. The... Agent: Townsend And Townsend And Crew LLP
20090283401 - Method for manufacturing liquid crystal device: A method for manufacturing a liquid crystal device that has a liquid crystal layer interposed between a pair of substrates which oppose each other and an alignment film which is formed on an inner face side of at least one of the substrates includes forming an inorganic alignment layer that... Agent: Harness, Dickey & Pierce, P.L.C
20090283402 - Hydrogen/oxygen fuel generator: A compact and portable system adapted for use in decomposing water and separating an oxygen rich gaseous stream and a hydrogen rich gaseous stream which produces a massive output of Hydrogen fuel, (along with the proportional amount of oxygen) capable of operating at varying levels of output, on-demand. This system... Agent: Dana Osman
20090283403 - Sensor element having improved dynamic properties: A sensor element, e.g., for measuring an oxygen concentration in an exhaust gas, has at least two electrodes and at least one solid electrolyte connecting the electrodes. The solid electrolyte has at least one first metal oxide as the solid electrolyte matrix material, and at least one solid electrolyte dopant.... Agent: Kenyon & Kenyon LLP
20090283404 - Reference electrode coated with ionic liquid and electrochemical measurement system using the reference electrode: This invention provides a reference electrode (3) that can be downsized and stable in voltage. The reference electrode (3) in accordance with this invention is a reference electrode (3) that does not require an internal aqueous solution such as a KCl aqueous solution and comprises a metal body (31), a... Agent: Alleman Hall Mccoy Russell & Tuttle LLP
20090283405 - Flow dielectrophoretic separation of single wall carbon nanotubes: According to some embodiments, a method for separating a first fraction of a single wall carbon nanotubes and a second fraction of single wall carbon nanotubes includes, but is not limited to: flowing a solution comprising the nanotubes into a dielectrophoresis chamber; applying a DC voltage, in combination with an... Agent: Winstead PC
20090283406 - Method and apparatus for detection of bioparticles by single-bead based dielectrophoresis: A method and an apparatus for detection of a bioparticle by single-bead based DEP. The method includes the steps of immobilizing a single DEP bead in one electric field; immobilizing a first bio-recognizing molecule on the single DEP bead; intromitting at least one target bioparticle into the electric field for... Agent: Bacon & Thomas, PLLC
20090283407 - Method for using magnetic particles in droplet microfluidics: Methods of utilizing magnetic particles or beads (MBs) in droplet-based (or digital) microfluidics are disclosed. The methods may be used in enrichment or separation processes. A first method employs the droplet meniscus to assist in the magnetic collection and positioning of MBs during droplet microfluidic operations. The sweeping movement of... Agent: VistaIPLaw Group LLP
20090283408 - Universal interface for a micro-fluidic chip: An integrated capillary electrophoresis system comprising a universal interface is disclosed. The universal interface includes one or more of the following structural elements: a chip assembly that receives a capillary electrophoresis CE chip; a fluidic interface for coupling fluids between the chip assembly and external sources or destinations; a first... Agent: Demont & Breyer, LLC
20090283409 - Under-sink apparatus for target pharmaceutical compound treatment: A target compound treatment apparatus of a size capable of being mounted under a sink, the apparatus comprising a destruction zone in which an aqueous solution containing at least one target compound is exposed to a destruction agent adapted to convert the target compound into destruction byproduct; a filtration zone... Agent: Edward L. White, P.C.11/12/2009 > 13 patent applications in 12 patent subcategories.
20090277771 - Treatment of fluids with wave energy from a carbon arc: A method and apparatus for treating a fluid using a wave energy uses a cyclone separator configured to create a flow of the fluid in a thin film along a vortex path from a first end to a second end of the cyclone separator, a first electrode and a second... Agent: Chalker Flores, LLP
20090277772 - Process for continous production of carbon fibres: A process for continuous production of carbon fibres whereby stabilised precursor fibres are carbonised and graphitised with the help of high-frequency electromagnetic waves, characterised in that the stabilised precursor fibres are continuously conveyed, as the inner conductor of a coaxial conductor consisting of an outer and an inner conductor, through... Agent: Oliff & Berridge, PLC
20090277773 - Method of manufacturing particle wire: A method of manufacturing a microwire or a nanowire formed of a metal-containing compound having a desired composition, including the steps of: (1) preparing a vapor or gas of an organometal compound and, if required, a vapor or gas of an optically excitable organic compound and/or a vapor or gas... Agent: Morgan Lewis & Bockius LLP
20090277774 - Treatment of fluids with wave energy from a carbon arc: A method and apparatus for treating a fluid using a wave energy uses a gas-sparged pipe configured to create a flow of the fluid in a thin film along a vortex path from a first end to a second end of the gas-sparged pipe, a first electrode and a second... Agent: Chalker Flores, LLP
20090277776 - Method and apparatus for plasma-treating porous body: A method for plasma-treating a porous body, comprising the steps of generating plasma using an inert gas or a mixed gas of an inert gas and a reactive gas, (a) blowing the resultant plasma gas to the porous body at a flow rate per a unit area of the porous... Agent: Sughrue Mion, PLLC
20090277775 - Reactor for removing chemical and biological contaminants from a contaminated fluid: A reactor apparatus and method for removing chemical and biological contaminants from a contaminated fluid while minimizing disinfection by-products, sludges, and harmful residue. The reactor has a sequential, multi-stage, reaction vessel with an upper end region and a lower end region. The vessel has a liquid inlet port into which... Agent: Brooks Kushman P.C.
20090277777 - Cold-pressed sputter targets: A sputter target includes a sputter material made of an alloy or a material mixture composed of at least two components which are in a state of thermodynamic disequilibrium. The components are compacted by an isostatic or uniaxial cold-pressing process.... Agent: Panitch Schwarze Belisario & Nadel LLP
20090277779 - Magnetic field generating apparatus, magnetic field generating method, sputtering apparatus, and method of manufacturing device: A magnetic field generating apparatus includes a magnet assembly group including at least three magnet assemblies arranged along a straight line, each of the magnet assemblies including a permanent magnet, spilt yokes which are formed by magnetic members and are placed to surround the outer surface of the permanent magnet,... Agent: Fitzpatrick Cella Harper & Scinto
20090277778 - Microwave rotatable sputtering deposition: Disclosed is an invention that uses a coaxial microwave antenna as a primary plasma source in PVD. The coaxial microwave antenna is positioned inside a sputtering target. Instead of using a cathode assist in sputtering, microwaves generated from the coaxial microwave antenna may leak through the sputtering target that comprises... Agent: Townsend And Townsend And Crew LLP
20090277780 - Sputtering device: The present invention relates to a sputtering cathode of the magnetron type and a control method for such a device for, in a vacuum process, depositing very thin films on substrates for a wide variety of commercial and scientific purposes including production of circular optical discs such as CD- or... Agent: Birch Stewart Kolasch & Birch
20090277781 - Magnetron sputtering apparatus and method for manufacturing thin film: In the present invention, in forming a LaB6 thin film by sputtering, the single-crystal properties in the wide domain direction in the obtained LaB6 thin film is improved. In one embodiment of the present invention, high frequency power from a high frequency power supply, and first direct current power after... Agent: Fitzpatrick Cella Harper & Scinto
20090277782 - Silicon oxynitride coating compositions: Silicon oxynitride compositions are described herein. These compositions are typically deposited onto substrates using a nitrogen plasma-based, reactive sputtering method. Depending on their composition, these coatings can be used for field emission suppression, dielectric applications, reflection control, and surface passivation.... Agent: William And Mary Technology Transfer Office
20090277783 - Machine with water heating means and anti-scale device: A machine provided according to the present invention is characterized in that it comprises an electrolytic cell (2, 22, 32, 42) eluting zinc ions in the process water, and in that it further comprises sensor means (11, 211, 211a, 311, 411) and processing means (12, 212, 312, 412) for determining... Agent: Pearne & Gordon LLP
20090277784 - Electrochemical device: An electrochemical device 1A has first and second electrode pads 5a and 5b on the upper surfaces 11 of protrusions 3a and 3b, and has first and second electrode pads 7a and 7b on the lower surfaces 13 of the protrusions 3a and 3b. First and second foil electrode terminals... Agent: Oliff & Berridge, PLC
20090277785 - Coaxial symmetrical completely open electrolytic bath: An electrolytic bath includes a shell, an upper cover joined on an upper end of the shell, an outer supporting member held in the shell, a hollow cylindrical positive electrode plate held in the outer supporting member, a hollow cylindrical negative electrode plate held in the positive electrode plate, an... Agent: Rosenberg, Klein & Lee
20090277786 - Plating processing line: A plating processing line or system includes a plurality of surface processing apparatus including a surface processing apparatus for processing a surface of an object to be treated by introducing a treatment liquid to the surface, and a conveyer unit for conveying the object to be treated, which is disposed... Agent: Barnes & Thornburg LLP
20090277787 - Rotatable sputter target comprising an end-block with a liquid coolant supply system: A tube target with an end block for supplying coolant to the tube target is provided. The end block comprises a rotatably mounted carrier shaft for holding and rotating the tube target; a connecting sleeve arranged in the carrier shaft; a sealing element for the tube target on its end... Agent: Heslin Rothenberg Farley & Mesiti PC
20090277788 - Sputtering target/backing plate bonded body: Provided is a sputtering target/backing plate assembly having a structure such that pure copper is embedded in a backing plate position at the central portion of the target, within sputtering target/copper-zinc alloy backing plate bonded bodies. Consequently, provided is a simple structure of sputtering target/backing plate capable of sufficiently accommodating... Agent: Howson & Howson LLP
20090277789 - Wireless chemical sensor and sensing method for use therewith: A wireless chemical sensor includes an electrical conductor and a dielectric material on the conductor. The conductor is electrically unconnected and is shaped for storage of an electric field and a magnetic field. In the presence of a time-varying magnetic field, the conductor resonates to generate harmonic electric and magnetic... Agent: National Aeronautics And Space Administration Langley Research Center
20090277790 - Individual identification method and apparatus: An individual identification method for identifying an individual by analyzing a DNA sample through electrophoresis, comprises: a first analysis step of analyzing an identifier-attached DNA sample which is given an identifier for an individual; a step of storing a result obtained by analyzing the identifier-attached DNA sample together with a... Agent: Sughrue Mion, PLLC
20090277791 - Method for separation and identification of biomolecules using unconventional gel electrophoresis and detection of single nanoparticle probes: A method for identifying and separating of target biomolecules is disclosed. The method involves contacting a sample with a nanoparticle probe that is capable of specifically binding a target biomolecule. The complex formed by the nanoparticle target biomolecule is separated by electrophoresis using a non-conventional gel composed of a synthetically... Agent: Klarquist Sparkman, LLP
20090277792 - Method for concentrating charged particles and apparatus thereof: The present invention discloses a method for concentrating charged particles and an apparatus thereof. The method comprises: providing a substrate comprising a reservoir; disposing a conducting granule in the reservoir, the conducting granule being negatively charged or positively charged and comprising nano-pores or nano-channels capable of permitting ion permeation; disposing... Agent: Hudak, Shunk & Farine, Co., L.p.a.11/05/2009 > 13 patent applications in 12 patent subcategories.
20090272642 - Method and arrangement for producing contacts on photovoltaic elements without carrier substrate: Please amend the Abstract of the Disclosure to read as follows. In accordance with 37 CFR §1.72, the abstract is submitted herewith on a separate sheet of paper, following page 9 of this amendment.... Agent: Heslin Rothenberg Farley & Mesiti PC
20090272641 - Sputter target, method for manufacturing a layer, particularly a tco (transparent conductive oxide) layer, and method for manufacturing a thin layer solar cell: In the present invention a sub-stoichiometric ceramic ZnOx:Al target, with 0.3<x<1, is used for depositing a ZnO:Al layer in a reactive sputtering process. The process is carried out in an Ar/O2 atmosphere. The diagram depicts the deposition rate R depending on the oxygen flow in a sputtering process according to... Agent: Townsend And Townsend And Crew, LLP
20090272643 - Composite anode well and revitilization method: A composite reconstituted anode well. The composite well has a first while section and a second regenerative section. The first well section has a pre-existing anode well earthen wall, pre-existing sacrificed carbon material, pre-existing sacrificed anode materials, and pre-existing sacrificed well casing. The second regenerative section has a regenerative well... Agent: Jellett Law, Ps Matthew Jellett, Esq.
20090272644 - Plating apparatus with direct electrolyte distribution system: A plating apparatus with direct electrolyte distribution system, including one or more of the following: an electrolyte tank; an electrolyte distribution compartment within the electrolyte tank, the electrolyte distribution compartment for containing electrolyte, the electrolyte distribution compartment having a first side and a second side; a pump having a fluid... Agent: Kramer & Amado, P.C.
20090272645 - Corrosion resistant gas diffusion layer with a micro protective layer for electrochemical cells: A gas diffusion layer with a micro protective layer is utilized in the electrochemical cells. The cell mainly includes end plates, current collectors, flow field plates, gas diffusion layers, catalyst layers, a proton exchange membrane and a circuit unit. When the cell functions as a fuel cell, hydrogen reacts with... Agent: Hdls Patent & Trademark Services
20090272646 - Insoluble electrode: Provided is an economical long-life insoluble anode capable of maintaining an anode function stably for a long time even if it is used in a part where severe consumption occurs to generate a cathodizing phenomenon, and also capable of reducing the amount of an electrocatalyst used as much as possible.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090272647 - Process kit for rf physical vapor deposition: Embodiments of the invention generally relate to a process kit for a semiconductor processing chamber, and a semiconductor processing chamber having a kit. More specifically, embodiments described herein relate to a process kit including a cover ring, a shield, and an isolator for use in a physical deposition chamber. The... Agent: Patterson & Sheridan, LLP - - Appm/tx
20090272648 - Syperhydrophobic nanostructured materials as gas diffusion electrodes for gas detectors: An electrochemical gas detector includes a superhydrophobic, nanostructured gas porous electrode. The electrode exhibits a physically disrupted porous region. In an embodiment, electrode material can be deposited around a templating material which is removed before use. Such electrodes exhibit repeatable and reproducible characteristics.... Agent: Honeywell International Inc. Patent Services
20090272649 - Method for study, determination or evaluation: A method for studying, determining or evaluating a pharmacological action of a test substance, the method including subjecting the brain tissue of an SART stressed animal administered with the test substance to an expression proteome analysis, where expression changes of NSF (N-ethylmaleimide sensitive fusion protein), which is or is not... Agent: Oliff & Berridge, PLCPrevious industry: Distillation: processes, separatory
Next industry: Electrolysis: processes, compositions used therein, and methods of preparing the compositions
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The Horse Forum (http://www.horseforum.com/forumindex.php)
- Tack and Equipment Classifieds (/tack-equipment-classifieds/)
- - Saddles wanted (http://www.horseforum.com/tack-equipment-classifieds/saddles-wanted-115594/)
Saddles wanted
This is a feeler thread - currently looking at a horse.
1) 16-17 western saddle with SQHB or FQHB with no silver. Prefer Abetta or Big Horn but open. $300 and under.
2) 17-18" AP English saddle with knee rolls/blocks in brown with reg, med or adjustable tree. No cheap brands, please. Under $300.
Bumping back up.
Looking for a western saddle only. :)
Sounds like I have exactly what you are looking for: http://www.horseforum.com/tack-equip...wanted-116961/
Let me know if you are interested, I am also willing to throw in the matching breast collar at no extra charge. :)
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Epigenetic modifications, such as DNA methylation and histone acetylation/methylation, play a critical role in dictating the function and behavior of an organism. Efforts to unravel the workings of the epigenome, however, are constrained by severe technical limitations in our ability to manipulate chromatin modifications. Existing approaches typically involve pharmacological agents or genetic modification and tend to have pleiotropic effects. This proposal aims to develop a universal set of tools for manipulating epigenetic modifications capable of targeting specific chromatin modifiers to any desired locus and precisely controlling the timing and magnitude of these modifications. The proposed platform is built on our recently demonstrated CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) interference system-a highly efficient RNA- guided genome-targeting system derived from the CRISPR bacterial immune system. The method requires only a single protein, dCas9, a catalytically inactive variant of the CRISPR Cas9 proteins, and a designed small guide RNA (sgRNA) with a region that is complementary to the gene of interest. The sgRNA guides binding of the dCas9-sgRNA complex to the complementary genomic site. We will develop a CRISPR RNA-based toolset for targeted and inducible manipulation of the epigenetic modifications First, we will develop a series of optimized dCas9-sgRNA pairs in which the DNA location of targeting is determined solely by the sequence of the sgRNA and the epigenetic impact of targeting is dictated by the effector domain that is recruited by dCas9. This will then be coupled with a genome-wide library of sgRNAs capable of targeting the dCas9 at will to roughly 100,000 positions in the human genome. Second, to enable inducible epigenetic controls, we will fuse the dCas9 proteins to a complement of diverse epigenetic modifier domains and effector domains that can be controlled by light or drugs. The epigenetic modifier domains will contain different catalytic and/or regulatory domains derived from natural epigenetic regulators, including both "writer" and "eraser" modules. Optogenetically and chemically gated interaction modules will be used to achieve spatial and temporal control. Third, we will apply these tools to a small set of pilot mechanistic and bioengineering studies to test how the CRISPR epigenetic toolbox can be utilized. Specifically, we will modify the epigenetic marks of the murine Oct4 and Sox2 loci as the endogenous experimental testbed, and study the importance of modifier recruitment positioning and dynamics in controlling chromatin state. Finally, we will develop programmable CRISPR insulators to control long-range chromatin interactions of human beta globin expression. Together, this project will provide a universal RNA-guided platform for precise spatial and temporal regulation of the epigenome. We envision this platform will be a critical tool for studying the interplay between multiple epigenetic modifirs at different loci, understanding the relationship between epigenomic programming and disease, and facilitate the development of therapeutic methods to rewrite and reprogram epigenetic marks.
The human epigenome, governing the chromatin structure organization and DNA or histone modifications, encodes important information related to human physiology and diseases, yet we lack effective methods to manipulate the epigenome, hindering efforts to unravel the principles underlying epigenetic control. To address this deficiency, the proposed research aims to develop a universal RNA-guided platform for precise spatial and temporal regulation of the epigenome, which will be widely applicable to write and erase multiple epigenetic marks for almost any endogenous genomic locus. These capabilities will be critical for studying the interplay between multiple epigenetic modifiers at different loci, understanding the relationship between epigenomic programming and disease, and facilitating the development of therapeutic methods to rewrite and reprogram epigenetic marks.
|Zalatan, Jesse G; Lee, Michael E; Almeida, Ricardo et al. (2015) Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 160:339-50
|Qi, Lei S; Arkin, Adam P (2014) A versatile framework for microbial engineering using synthetic non-coding RNAs. Nat Rev Microbiol 12:341-54
|Tanenbaum, Marvin E; Gilbert, Luke A; Qi, Lei S et al. (2014) A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell 159:635-46
|Gilbert, Luke A; Horlbeck, Max A; Adamson, Britt et al. (2014) Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell 159:647-61
|Ji, Weiyue; Lee, Derrick; Wong, Eric et al. (2014) Specific gene repression by CRISPRi system transferred through bacterial conjugation. ACS Synth Biol 3:929-31
|Qi, Lei S; Arkin, Adam P (2014) A versatile framework for microbial engineering using synthetic non-coding RNAs. Nat Rev Microbiol 12:341-54


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I Shall Not Hate
A Gaza Doctor's Journey
A Palestinian doctor who was born and raised in the Jabalia refugee camp in the Gaza Strip, Izzeldin Abuelaish is an infertility specialist who lives in Gaza but works in Israel. The Gaza doctor has been crossing the lines in the sand that
divide Israelis and Palestinians for most of his life--as a physician who treats patients on both sides of the line, as a humanitarian who sees the need for improved health and education for women as the way forward in the Middle East. And, most recently, as the father whose daughters were killed by Israeli soldiers on January 16, 2009, during Israel's incursion into the Gaza Strip.
It was Izzeldin's response to this tragedy that made news and won him humanitarian awards around the world. Instead of seeking revenge or sinking into hatred, he called for the people in the region to start talking to each other. His deepest hope is that his daughters will be "the last sacrifice on the road to peace between Palestinians and Israelis."
Sand and Sky
It was as close to heaven and as far from hell as I could get that day, an isolated stretch of beach just four kilometres from the misery of Gaza City, where waves roll up on the shore as if to wash away yesterday and leave a fresh start for tomorrow....
A Globe and Mail Best Book
Heather's Pick
"In this book, Doctor Abuelaish has expressed a remarkable commitment to forgiveness and reconciliation that describes the foundation for a permanent peace in the Holy Land."
— President Jimmy Carter, Nobel Peace Prize laureate
"It is impossible to read this book without feeling deep compassion for Abuelaish and his surviving children, and profound respect for his determination to turn tragedy into triumph."
— Winnipeg Free Press
"A passionate human cry for peace and understanding."
— Jonathan Garfinkel, The Globe and Mail (Best Book)
"This story is a necessary lesson against hatred and revenge."
— Elie Wiesel, Nobel Peace Prize laureate
"Powerful. . . . Moving. . . . Abuelaish does not attempt to set out a political solution to the conflict. He simply tells his own story, with clarity and a humanity of vision."
— The Gazette
"A vivid, haunting and all but heartbreaking account. . . . Fast-paced, skillfully organized and highly evocative."
— Toronto Star
"Unshakeable courage, optimism and belief in the healing power of love is [Abuelaish's] story. . . . This book, penned from the heart, with grace and insight, is his way of engaging us all in this quest [to create peace between Israelis and Palestinians]."
— Heather Reisman, Heather's Pick


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16 Comments
Realtime comments disabled
ddritzenhein 2438 days ago
Beautiful Scenary
CerenFCB 2441 days ago
really good pic!
cardsfan11a 2441 days ago
wat happened to spain steve? I hope mexico wins tomorrow and the U.S. on friday
brydonredding 2441 days ago
Crazy that Spain lost today!
leafya99 2441 days ago
the view is really gorgeous!
EarlaRiopel 2441 days ago
Wow! Beautiful view Steve! Have fun at the World Cup! Go Spain! :)
eastlands1 2441 days ago
damn awesome scenery man. Spains team is so stacked, and torres isnt even playing yet!!! CTID!
SusieQ_L 2441 days ago
Thanks so much for sharing this lovely pic! Be safe, have a ball! Vayase, hombre! Hugs
Nba_Video 2441 days ago
One of the best assister of the NBA watching two great assisters of #esp. Que grande eres @the_real_nash
beamoore61 2441 days ago
BTW! Lovely Coastline! Have fun over there.
beamoore61 2441 days ago
No way, Steve! Stay in Phoenix. Although, it would be nice seeing you & Shawn & Dirk 2gether agin
chellebelle21 2441 days ago
wow thats beautiful!!! good luck!
Danielson93 2441 days ago
Nash come back to Dallas!
Chabi84 2441 days ago
enjoy the match! I'll be watching it by tv. good luck for spain, my country!
DinosharkVsDom 2441 days ago
hope the box wasn't too uncomfortable, also that Spain can liven up this world cup!
Carlos_Barrutia 2441 days ago
Both incredible players! Go Spain!


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This houndstooth cloche style hat is a classic. The textured rope band at the crown adds a modern touch to a vintage style. Flattering for any age, this smart and stylish hat is the perfect compliment to any winter outfit.
UPF Rating: UPF 50
Brim Width:1.75"
Adjustable Chinstrap?No
Adjustable exterior headband to size down?No
Material:Felt Wool
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Wayne Rooney net worth: Wayne Rooney is a British footballer who has a net worth of $145 million and annual salary of $26 million. But it's not his net worth that's made him a famous soccer player around the globe – rather it's been his skill and talent in football that put him on the map. His athletic career began as he was a very young child, playing football with the Liverpool Schoolboys. He seemed destined for greatness even then. At one time he held the organization's record for most goals scored in a single season, at 72 goals. As Rooney grew older, his football star continued to rise, until eventually he was playing for Everton, making his senior debut in 2002, becoming the youngest-ever goal scorer at Everton at the age of 16. In 2004, the outstandingly valuable Rooney was snatched up by Manchester United, where he remains today. His career with that organization has been as distinguished as everyone could expect, continuing to break records with the team. Like many big soccer players, Rooney has a career in international football as well, playing in several World Cups.
Wayne Rooney Net Worth
Wayne Rooney
Football player
Date of Birth
Oct 24, 1985 (31 years old)
Football player, Soccer Player
United Kingdom
5 ft 9 in (1.76 m)
175 lbs (79.4 kg)
More Soccer Players
All net worths are calculated by applying a proprietary algorithm. The results are then fact checked and confirmed by a team of editors. We scan all publicly available data and resources and work diligently to ensure that our numbers are the most accurate and up to date net worth data you will find anywhere on the internet.


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Term: Pantheism
Pantheism: The belief that everything is God.
The story of the Golden Dawn, like that of any human organization, is replete with high points and low points—with human achievements and human failings. There is no need for us to try to whitewash or sugarcoat the faults of some of the individuals ...
Relevance: 2%
To mention the word Druid is to evoke images of ancient wizards and wonder-workers from old Irish sagas, Welsh legends, Caesar's Gallic Wars and Scottish folktales. If you have read about the Druids, you've probably retained one of their many images ...
Relevance: 2%


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Ubiquitin System: The Next Class of Drug Targets?
A Complex Role in Cellular Process & Growing Tool Set to Elucidate It
Bispecific Antibodies Close in on Cancer
Plotting Molecular Pincer Movements, Denying Cancer Room to Maneuver
Troubleshooting SPR
Resolving Nonspecific Binding, Regeneration and Other Problems
Data Deluge
Researchers Turn to Cloud Computing as Genomic Sequencing Data Threatens to Overwhelm Traditional IT Systems
Scientists Create Targeted Knockout Rats Using Sangamo's Zinc Finger Nuclease Technology
A group of scientists report the creation of the first genetically modified rats using Sangamo Biosciences zinc finger nuclease (ZFN) technology. The rats had permanent, heritable gene mutations, which paves the way for the development of novel genetically modified animal models of human disease, according to the researchers.
"Until now, rat geneticists lacked a viable technique for knocking out, or mutating, specific genes to understand their function," states Howard Jacob, Ph.D., director of the human and molecular genetics center at the Medical College of Wisconsin. "This study demonstrates that ZFN technology bypasses the current need to conduct cumbersome experiments involving nuclear transfer or embryonic stem cells and allows rapid creation of new animal models."
The study appeared in the July 24 issue of Science and is titled "Knockout Rats via Embryo Microinjection of Zinc Finger Nucleases." Besides investigators from the Medical College of Wisconsin and Sangamo, the research team included scientists from Sigma-Aldrich, Open Monoclonal Technology, and INSERM.
They used ZFNs to knock out an inserted reporter gene and two native rat genes without causing measurable effects on other genes. Importantly, offspring of the ZFN-mutated rats also carried the modifications, demonstrating the genetic changes were permanent and heritable. Together, these results demonstrate the ability to deliver engineered ZFNs into early-stage embryos and generate heritable, knockout mutations in a whole organism.
ZFNs are engineered proteins that induce double strand breaks at specific sites in an organism's DNA. Such double-strand breaks stimulate the cell's natural DNA-repair pathways and can result in site-specific changes in the DNA sequence. ZFNs have reportedly been used to knock out specific genes in fruit flies, worms, cultured human cells, and zebrafish embryos. They are also currently in clinical trials for the treatment of HIV/AIDS.
Sigma-Aldrich, the sole source of commercial zinc finger nucleases for the research community, markets Sangamo's ZFN technology through its CompoZr™ line of products and services.
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I've expanded the etymology of the term. I deleted a paragraph about problems with the AI field. It was correct, but not related to the topic of the page. --LC
I deleted the "MindForth" code, which does not belong here, also known as "example" in previous edits. Montalvo 8 July 2005 05:25 (UTC)
If this term was coined by Fanya S. Montalvo, why is there reference for this author?--188.8.131.52 13:19, 19 October 2005 (UTC)
I'm not an expert in computer AI terminology, but perhaps some parts of this article ought to at least be clarified. The phrase "AI-hard" and a direct reference to "NP-hard" in computational complexity theory makes it sound like an AI-hard problem is one to which every problem in AI (presumably the class of problems that can be solved effectively by strong AI) can be reduced. Yet, problems that are given as examples of AI-complete (therefore AI-hard, I assume?) seem to not have the property of every problem solvable by strong AI being reducible to those problems. For instance, speech recognition cannot be reduced to go-playing in any way I am familiar with. I understand quite well that there is not a perfect analogy between the class NP and the class AI, but perhaps this should be clarified some more in the article? Am I correct to think that the coining of this terminology was more professional humor than anything else? —Preceding unsigned comment added by 18.104.22.168 (talk) 20:25, 14 September 2008 (UTC)
this article has got to be total bs. if this is what the AI community has come down to, God help us... --unsigned
Why is this article tagged with Computational complexity theory? It has nothing to do with it. It just borrows from words from complexity theory. This topic would not appear in any text book on complexity theory. I removed the category, but was reverted [1]. --Robin (talk) 14:08, 5 January 2010 (UTC)
- Hello, yes I reverted. The reasoning is that the formalisation in the article is a generalisation of conventional computational complexity: it defines a computation as having both human and computer components and there are equivalence classes of these computations. The article Complete (complexity) is in the computational complexity category so AI-complete, as a generalisation, appears (to me) to belong there too. It probably doesn't appear in textbooks because it's quite recent. Disclaimer: I have no connection with this work but think it is an interesting and useful notion. pgr94 (talk) 13:05, 9 January 2010 (UTC)
- Hi, thanks for the response. The thing is, that "complete" has an extremely precise mathematical definition on computational complexity theory. Indeed, all of computational complexity theory is very mathematical, and there are no vague notions. AI-complete, on the other hand, is a fairly vague notion, and an informal one at that. There's no mathematical problem that is proven to be AI-complete, and indeed that might not be possible, since the problem "make machines behave like humans" would not even be expressible mathematically. It seems like AI-complete borrows terminology from complexity theory just to indicate the hardness of some AI problems in an informal sense. These problems are not complete in the technical sense of complexity theory. Moreover, "AI" is not a complexity class in complexity theory, unlike NP-complete (related to the class NP (complexity)) or PSPACE-complete (related to the class PSPACE). For all these reasons, I don't think this article should be in Category: Computational complexity theory. --Robin (talk) 14:53, 9 January 2010 (UTC)
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Chris Young Announces Date for 2015 Fan Club Party
Chris Young knows how to throw an unforgettable party, and his fans are invited.
Chris Young knows how to throw an unforgettable party, and his fans are invited.
It may still be icy cold in Nashville, but that's not stopping Sports Illustrated from celebrating like it's summertime.
CDs? Tickets? T-shirts? Every country star has signed a thousand of those, but only one man has signed a dirty sock. OK, maybe two people have. Find out who will and won't sign a baby, why Scotty McCreery gave a weirdo the Sharpie and the bizarre twist to Luke Bryan's answer in this video.
Two of country music's hottest young performers have teamed up for a string of co-headlining concert dates this winter.
Chris Young traveled to Miami over the weekend to receive an honor from a very special group of young people.
The fans have spoken and requested Chris Young be the subject of the first 'You Think You Know Country?' episode of 2015.
Chris Young is teaming with Kidde Fire Safety to promote a national fire safety campaign.
Chris Young is packing his bags (and passport!) in preparation to head overseas. The singer has announced his A.M. World Tour, which kicks off in March in Australia.
Trucks and guitars are typically exchanged after a major country tour wraps up (Miranda Lambert bought Carrie Underwood a motorcycle after she recorded 'Somethin' Bad). But Dierks Bentley takes the prize for most creative, unusual and potentially dangerous thank you gift.
Country's biggest stars have taken the challenge -- the Ice Bucket Challenge! It turns out, dumping a bucket (or many buckets) of freezing cold water on your noggin brings in lots of money for ALS, as millions of dollars have been raised since Blake Shelton and company started taking the plunge.
Chris Young's new song 'Lonely Eyes' is sneaky. At first, his story and familiar shuffle are easy to dismiss as just another fine croon from the 29-year-old. But listen closer.
Strap on your helmets and put on your dancing shoes! Dierks Bentley's ninth annual Miles & Music for Kids is going to be filled with roaring motorcycles and popular country stars like Kip Moore, Chris Young.


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HS admissions: Register now for our fall workshopsWritten by Insideschools staff Monday, 12 September 2016 09:09
Got an 8th-grader at home? Then you must be gearing up for high school admissions. Our advice: Check out our tips and handy action plan for making the most of your high school search and register for our fall high school admissions workshops!
Insider tips on specialized high schools: September 27, 6 pm
Are you auditioning for LaGuardia? Taking the SHSAT and wondering how to rank the specialized high schools? Got questions about the academics or homework load? Join the InsideSchools staff along with specialized high school students and parents on Sept. 27 for a panel discussion moderated by Clara Hemphill, followed by a Q&A session. RSVP on Eventbrite.
Best Bets for the "B" Student: October 5, 6 pm
Everybody hears about the tip-top schools, the ones that accept only "A" students and ace testers. But what about the average student? What are some good high school options for the "B" student? Join Clara Hemphill and the InsideSchools staff for a panel discussion designed to help you sort out your options. Got other high school admissions questions? We'll tackle those too. RSVP on Eventbrite.
College counselor: Starting over after two yearsWritten by Dr. Jane S. Gabin Sunday, 11 September 2016 12:51
Q: In high school, I was sure I wanted to enter the police force, so I attended a police academy for two years. But then I realized this was not the right career for me, and I left the academy. Now I want to apply to a regular college, but am really worried about this. Will my chances of admission be less because I went to the police academy? I want to get into a top school, but will they consider me good enough for their programs? I am concerned that I might not get in at all, and that my earlier choice might affect my future. What should I do?
A: Don't be so harsh with yourself! A lot of young people make a choice they think is appropriate for them AT THE TIME, but which turns out not to be the right choice. Do you think you're the only one? What about the student who spends a year or two in nursing school, and then realizes her heart isn't in it? Or the one who studies engineering and then discovers it's really math that he wanted?
High School Hustle: Let LaGuardia be LaGuardiaWritten by Liz Willen Monday, 22 August 2016 11:22
The call to our home came a few months into my older son's freshman year at Fiorello H. LaGuardia High School of Music & Art and Performing Arts, the performing arts public high now under fire for prioritizing academics over talent.
"This is Dr. Barbara Rowes, and I have something to tell you.''
My heart caught in my throat as I waited to hear from this feared but highly respected English teacher, notorious for setting seemingly impossibly high standards at the school made iconic in the 1980 movie "Fame".
"Now, I know that your son wants to be a rock star,'' she told me. "But I just finished grading his paper. I think he has a future as a scholar."
I knew he'd been struggling. And now, here was one teacher in this sprawling school of the arts who cared enough about his writing progress to let me know—a measure of how seriously the school takes its dual mission of both college and conservatory arts preparation.
Applying to middle school? Tips from a 6th-graderWritten by Nathaniel Cain Tuesday, 16 August 2016 14:53
Applying to middle school—a process that begins in the fall of 5th grade—can be stressful if you don't know what you're doing. It's very important that you stay on task.
My name is Nathaniel Cain and I am a soon-to-be 6th-grader at MS 51, the William Alexander School in Brooklyn's District 15. I comment on Insideschools frequently and you may know me from my profile, "sixthgrader."
When I was applying to middle school, I had two challenges: 1. There are no zoned middle schools in District 15; and 2. I was living in one of the most competitive school districts in all of New York City. Your struggles may be different.
Here are some tips as you navigate through the middle school process, whether you're a parent or a rising 5th-grade student:
How to rule your school: Advice for rising 9th-gradersWritten by Insideschools staff Monday, 15 August 2016 13:00
By Katie Radvany and Kaia Tien
If you're a rising freshman, you're probably already freaking out about your first day of high school. But everyone is just as terrified as you are. You might think everyone is going to be in a competition to rise to the top of the social strata, but being at the top is overrated. High school is only four short years, so you might as well spend it with the people you like.
Do's and don'ts:
We've been through this year ourselves, and we have a lot of advice to offer. But the most important thing to remember is do not, under any circumstance, use a rolling backpack. Everyone will be giving you dirty looks in the halls when they trip over it.
Summer homework: Start your high school search nowWritten by Insideschools staff Monday, 01 August 2016 14:39
The first few months of 8th grade can be a hectic time for kids and parents. It's easy to lose track of all you have to do for high school admissions. Our advice to rising 8th-graders and families: Don't wait until September to start your high school search.
Summer is a great time to start researching and compiling a list of schools you want to apply to in the fall. Check out our written and video guides on applying to high school. Use Find a NYC Public School to search among the city's 400+ high schools for ones that may be a good fit for you.
Didn't make it to one of the Department of Education's high school admissions workshops held in July? Don't worry. You can find a recap of the July sessions here, and there will be more opportunities for 8th-graders to learn about high schools in the fall at open houses and at the city- and borough-wide high school fairs.
To help you get started, we compiled some useful information and advice into a handy packet for you to review this summer. Read and print it out here or click on the link below to download. It includes tips on how to get yourself organized, answers to frequently asked questions about the specialized high schools and our action plan, a step-by-step checklist to help you stay on top of everything you need to do between now and the high school application deadline in early December.
A long, hungry summer? Filling the nutrition gap for kidsWritten by Insideschools staff Wednesday, 29 June 2016 14:16
by Karra Puccia
During 10 months of the year, hundreds of thousands of New York City kids eat free school breakfasts and lunches. These meals constitute a vital lifeline for families with already-stretched food budgets. So for many such families, the June 28th last day of public school classes may be less about planning summer fun for the kids and more about facing a serious months-long gap in their nutrition.
It doesn't have to be that way. Each year, the federal Summer Food Service Program (which New York City's Department of Education administers under the name "NYC Summer Meals") provides free breakfasts and lunches to all kids 18 and younger—without registration, documents or ID required. From June 29th—the first full day of summer school vacation—right through September 2nd, Summer Meals will be offered weekdays at public schools, Parks Department outdoor pools, New York City Housing Authority complexes, libraries, food pantries, soup kitchens, community organizations and other locations throughout the city. There will also be four mobile food trucks providing meals seven days a week.
Unfortunately, the Summer Meals program can seem like the world's best-kept secret. Food Bank For New York City is in a position to know. We serve nearly 1.4 million people—almost one out of every five New New Yorkers –through a network of food pantries, soup kitchens and community-based charities. And our October 2013 report, "Hunger's New Normal: Redefining Emergency in Post-Recession New York City," which was based on interviews with more than 1,200 people using food pantries and soup kitchens in all five boroughs, found that a whopping two-thirds of families using those resources don't take advantage of Summer Meals. The number one reason? They don't even know about it.
From LEGO to underwater robotics: Coney Island teachers create marine science "pipeline" for studentsWritten by Chalkbeat Monday, 27 June 2016 14:48
Originally posted on Chalkbeat by Monica Disare on June 27, 2016
When people think of Coney Island, they often picture a beachline with brightly colored roller coasters and hot dog stands, but high school teacher Lane Rosen sees it a laboratory for the next generation of marine scientists.
"People don't realize there's 567 miles of coastline in New York City," Rosen said. "There's tens of thousands of jobs, but we're not training anybody for any of them."
Rosen and a group of teachers in Coney Island have a radical plan to transform education in their neighborhood: build a marine science pipeline that helps guide a student all the way from the first day of elementary school through college or into a career.
Diversity in New York's specialized schools: A deeper data diveWritten by Insideschools staff Wednesday, 22 June 2016 15:53
by Nicole Mader, Bruce Cory, and Celeste Royo
The most recent Urban Matters ("Tough Test Ahead: Bringing Diversity to New York's Specialized High Schools") reported on patterns of racial and ethnic admission to some of the city's most prestigious secondary schools and how admissions might more closely mirror the overall composition of the city's public schools. As we showed, only about 16 percent of high-performing Black and Hispanic middle school students gain admission to these elite public high schools.
This week we're following up on comments and questions we received from you.
First, we show all 7th graders in 2012-13 by race, ethnicity and performance level at all 536 public middle schools (including charter schools). At the top of this chart, we see the handful of "feeder" middle schools that send high-performing students of all races to the eight high schools that rely on the specialized high school admissions tests (SHSAT). But we also see hundreds of schools that fail to prepare any students for these specialized schools. Click here to see the chart.
Tough test ahead: Bringing racial diversity to specialized high schoolsWritten by Insideschools staff Wednesday, 15 June 2016 16:08
By Bruce Cory, editorial advisor and Nicole Mader, data analyst at the Center for New York City Affairs.
There's a longstanding debate about why so few Black and Hispanic students are admitted to New York City's specialized high schools, including Stuyvesant, Bronx Science and Brooklyn Tech. They accounted for fewer than 9 percent of students offered admissions at eight specialized schools for the current school year; that's down from 9.6 percent the year before. Some say the specialized high school admissions test (SHSAT) is discriminatory and should be scrapped; others say the test merely reflects the poor preparation most Black and Hispanic students, who make up some 68 percent of public school enrollment, get in the elementary and middle schools.
Now, new research by the Center for New York City Affairs shows that even Black and Hispanic students who do very well in middle school—that is, those who as 7th-graders earn the best possible scores on either math or English language arts (ELA) state standardized tests—are much less likely to attend specialized high schools than their similarly high-performing Asian or White classmates.
This suggests that the City's Department of Education (DOE) may be able to increase Black and Hispanic specialized high school admissions without scrapping the SHSAT (a politically daunting task) or completely overhauling the elementary and middle schools. It offers hope that plans announced last week to increase the diversity of students taking and passing the SHSAT could produce progress.


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On January 8, 2013, the Supreme Court of the State of New York conducted a hearing in a criminal case that may cause concern among software developers whose software could be used for illegal activities.
In February 2011, Robert Stuart and his wife were confronted by authorities at their Arizona home with potential charges ranging from money laundering and operating an illegal enterprise to engaging in the promotion of gambling. The potential charges stemmed from Mr. Stuart's software, called Action Sportsbook International (ASI), which provides infrastructure for online casinos and sportsbooks to run betting operations.
While opinions regarding whether certain forms of gambling are illegal appear to be changing, it is still illegal in New York to operate an online sportsbook or horse racing betting business. It is also illegal in New York to aid and abet someone in the operation of such an illegal gambling business.
Initially Mr. Stuart signed a plea agreement that would have required him to install a "back door" into ASI to collect information on online gamblers; however, Mr. Stuart later rescinded the agreement. Consequently, in October 2012, Mr. Stuart, his wife, his brother-in-law and his company were formally charged under New York Penal Law § 225.10, which states that "[a] person is guilty of promoting gambling in the first degree when he knowingly advances or profits from unlawful gambling activity by . . . [e]ngaging in bookmaking to the extent that he receives or accepts in any one day more than five bets totaling more than five thousand dollars."
According to the New York County district attorney, the defendants each "knowingly advanced and profited from unlawful gambling activity by engaging in bookmaking to the extent that [the defendants] received and accepted in any one day more than five bets totaling more than five thousand dollars." The New York County District Attorney's Office has not publicly alleged that Mr. Stuart accepted any bets, but it has alleged that others used ASI to make or receive illegal bets. The district attorney's office also alleges that the quarterly licensing fees paid to Mr. Stuart's company by businesses that were licensing ASI directly resulted from illegal gambling operations by third parties in the United States. It appears that the district attorney's reasoning is that by distributing software that facilitates betting or wagering infrastructure and by taking licensing fees, Mr. Stuart (indirectly at least) accepted illegal bets and profited from illegal gambling. The district attorney may also argue that by accepting payment, the source of which may have derived from illegal bets, Mr. Stuart accepted illegal bets. Although each line of reasoning may come as a surprise to some, the end result is that Mr. Stuart is being held accountable for others' illegal activities using a product that he developed and licensed for lawful purposes.
Mr. Stuart, in discussing the charges, has stated that he simply licensed ASI to his customers, all of whom he says are abroad and operate in jurisdictions where online gambling is legal. Because online gambling is legal in the jurisdictions where his clients reside, he says he had no knowledge of any illegal operations. However, his claims of ignorance may not be enough: Under New York Penal Law § 15.05(2), a "person acts knowingly with respect to conduct . . . described by a statute defining an offense when he is aware that his conduct is of such nature or that such circumstance exists." In Mr. Stuart's case, this may mean that he may have been aware that ASI may have been used for illegal gambling. Software companies should note that, under federal law and possibly the law in other jurisdictions, a person's "knowledge" includes his or her intentional ignorance of facts that indicate unlawful activity. This means that if a company actively ensures that it remains unaware of illegal use of its software, it could still be prosecuted for knowingly engaging in illegal activity.
Here, Mr. Stuart's company received licensing fees for ASI in three ways: (1) by wire transfer; (2) by cash deposits made directly into his company's bank account; and (3) by money orders deposited directly into his company's bank account. Because cash and money orders are unusual methods of payment for software licenses, Mr. Stuart, it can be argued, should have been aware that the payments could have been made up of proceeds from illegal gambling. Consequently, Mr. Stuart may have "knowingly" been accepting illegal bets from the licensees of ASI in the form of licensing fees. Similarly, the license to ASI permitted licensees to sublicense the software to others without Mr. Stuart's knowledge or consent. Because the license permitted sublicensing without Mr. Stuart's consent, and indeed Mr. Stuart knew that ASI was often sublicensed to casinos or sportsbooks, he may have been aware that ASI may have been used to take illegal bets. That ASI was freely sublicensable, coupled with the fact that the popularity of illegal online gambling in the United States is well known, bolsters the likelihood that he was aware that a licensee in a jurisdiction where online gambling was legal could have freely sublicensed ASI to illegal gambling operations in the United States.
This action against Mr. Stuart and the other defendants is still in its early stages, and the strength of the district attorney's case remains to be seen. Software companies, however, should pay attention to how this case proceeds. Prosecution of a software developer for crimes committed by its users sets a dangerous precedent and starts the country down a slippery slope of prosecuting people for others' acts.
The key practice tips for software developers who license software for operations that are legal in some jurisdictions but not others are as follows:
See more »
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
© Perkins Coie
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Cheap flights to Medellin Enrique Olaya Herrera
Information about Medellin Enrique Olaya Herrera
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Best Of :: People & Places
Someone once told us, "If you don't find what you want at the Fordham Road shopping strip, go look for it in Jersey." By last count, there were nearly 120 stores and restaurants on this venerable road, with everything from diamonds to hardware. There are national names including The Gap and American Place, outlets for name brands Nine West. There's even a first-rate comic book store, Fordham Comics, and four—count 'em, four—tattoo shops. (Try finding that in Jersey.) You can eat the usual fast food, but some of the restaurants are a cut above strip-mall level—particularly Dickey's Barbecue Pit and Parrilla's Latina Steakhouse, both of which come highly recommended. An easy subway or bus ride from the other boroughs. Fordham Road, from Jerome to Webster avenues, The Bronx
New York is full of charming 19th-century streets, but one that's less known and kind of hard to get to only makes it more charming and more 19th-century. Our current fave owes its relative obscurity to its location in what's become a time-capsule pocket neighborhood in Brooklyn. We're talking Vinegar Hill here, bounded by DUMBO on the south, the East River to the west (strange as that sounds), the Navy Yard to the north, and the oppressive Farragut Houses to the east. And if Vinegar Hill could be said to have a main street, it's the lovely and atmospheric Hudson Avenue, which blissfully retains its intimate 1800s feel. Walking down it, the street feels almost like a movie set, as improbable as it looks in 2011. The Vinegar Hill House restaurant is likely what brings most outsiders to the street these days, but we recommend a lingering stroll along it anytime. Although a couple bottles of Lighthouse Ale at the rustic bistro's bar will certainly lend Hudson Avenue an extra glow.
Streetsblog founder, Honku creator, and longtime bike-lane advocate Aaron Naparstek is not an easy person to ignore. While the biking community, such as it is, has worked with the bike-lane-friendly Transportation Commissioner Janette Sadik-Khan, years on the margins have made its advocates a touchy group. Naparstek and acting Streetsblog EIC Ben Fried have pushed back hard against what they've seen as anti-biking messages and reacted aggressively and in concert with organized pro-bike interests to fight against bad press—even just loose tweets and asides—and to push stories about injured bikers and the perfidy of the anti-biking forces. In the course of that, they've managed to earn the resentment of some media types with what can come off as disproportionately aggressive responses. Joining an older and out-of-vogue tradition of advocates who might be addled but are basically right on the facts, Naparstek, currently on a fellowship at Harvard but continuing to weigh in frequently on New York issues, is a force to be reckoned with, especially as long as he can keep the commissioner's ear.
New York City is a land full of cheap dates. Where else can you make a perfectly entertaining and even romantic outing out of traipsing over a bridge, catching a ferry, going on a long, meandering walk through neighborhoods known and unknown, maybe stopping in a bar or restaurant for some drinks or food, maybe packing your own to take along with you and stopping at a green spot to snack? A favorite of ours is taking the cheap (free on weekends) Ikea ferry from Pier 11 at Wall Street to Red Hook, Brooklyn, on a sunny day. Jump off the ferry and head down to Van Brunt Street, where you can browse boutique wine stores and art galleries, relax with a pint at the taxidermy- and tchotchke-filled bar Bait and Tackle, have a proper dinner (less cheap, equally delicious), or just a drink at The Good Fork or Fort Defiance, or get fresh lobster rolls at the Red Hook Lobster Pound and enjoy them sitting on a bench outside the store. For dessert, if you have cash left, head to Baked. All on Van Brunt Street: nywatertaxi.com/tours/ikea, redhookbaitandtackle.com, goodfork.com, fortdefiancebrooklyn.com, redhooklobster.com, bakednyc.com
Oh, jeez—construction. Construction and trucks. Construction and trucks and rumble sirens. Construction and trucks and rumble sirens and people bitching into their cell phones. In other words, New York City. Really, sometimes it just has to stop. It's not always so easy to zip out of town to flee the oppression, so the city's little in-town escapes seem all the more precious. Our choice these days is nestled behind a low brick wall at Hudson and Barrow streets in the West Village and comes to us courtesy of those good people the Episcopalians. What they've done, see, is nurture their beautiful Garden at St. Luke in the Fields into something quite lovely and soothing. Tend it and love it, then open the gates and let us undeserving public people in to enjoy its lush Edenic calm. Sigh. Thank you, Episcopalians. Check it out next time you're in the nabe and need a quick calm-down. But leave a nice donation in the little box on your way out, or St. Luke might have a few words for you in his next gospel.
The only kind thing to be said about sports-talk callers—"not for nothing, Mike, but if I was making $6 million a year I'd hustle down the first baseline"—is that they're not as terrible as sports-talk hosts (excluding the great Steve Somers), perhaps because they get cut off after a few minutes instead of having to fill hours of airtime with their addled "ideas." The only kind thing to be said about sports-talk-radio hosts is that they're less offensive than political-talk-radio hosts, if only because the stakes are so much lower that their stupidity is less consequential. And political-talk-radio hosts at least share the aggrieved tone of their sports-talk kin, which puts them both up on the toneless dullness of public-radio hosts, lulled into deep self-satisfaction by their own voices and affect. Brian Lehrer would be a hell of a radio man if the bar was set much higher, but given the alternatives, his smart topics, deep knowledge of New York (among many other topics), willingness to ask simple and direct questions and to listen to the answers makes him the city's indispensable moderator. WNYC 93.9 FM and 820 AM 10 a.m. to noon Monday through Friday


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Report: Ashton Kutcher Asking Demi Moore Not to File for Divorce
Ashton Kutcher is reportedly trying to save his marriage to Demi Moore. Shortly after Us Weekly published Sara Leal's confession over their September 24 affair, Radar Online came with a report that the "Two and a Half Men" actor has been asking his actress wife not to file for divorce.
"Ashton was hoping that Sara wouldn't give any interviews about their sexual encounter, but now she's spilling all the seedy details and it doesn't help matters at all," said a source close to the 33-year-old actor. "Ashton is asking Demi not to file for divorce, but there is nothing he can do to stop her."
The inside source further claimed that 48-year-old Demi is "currently consulting with divorce attorneys". Although Ashton has reportedly been telling friends and associates Demi is likely to file for divorce, he actually "doesn't want her" to make the move, and "is hoping they can work it out."
Having said that Ashton "is absolutely gutted", the insider continued to spill that the "No Strings Attached" star "had confessed his sexual relationship with Sara to Demi after it happened." The source added, "Demi was naturally, devastated, but not surprised as they had spent their sixth wedding anniversary apart. There have been problems for a very long time in the marriage."
Marriage trouble aside, Demi herself has her new Holiday 2011 campaign for Ann Taylor. Putting on a brave face and sporting faint smile, the former wife of Bruce Willis posed in a Nordic Winter Wonderland setting for the photos taken by famed fashion photographer Norman Jean Roy in Los Angeles.
Speaking about the gig, Demi said in a press release, "It has been a true pleasure to continue my collaboration with Ann Taylor." She added, "The energy and enthusiasm behind the evolution of this iconic brand is remarkable, and being a part of that has been a wonderful creative experience. The new Ann Taylor is so chic, and I personally love their Holiday collection."
More Ashton Kutcher News
- Tarek and Christina El Moussa 'Desperately Trying' to Stay in the Limelight by Eying Solo Shows
- Kylie Jenner Goes Makeup Free During a Day Out With Tyga
- Listen to Lana Del Rey's Long-Awaited Dreamy Song 'Love'
- Liam Payne Is Doing Home Renovation Before Cheryl Gives Birth
- Britney Spears Bares Her Naked Body in NSFW Instagram Pic
- 'The Walking Dead' 7.11 Sneak Peeks: What Happens to Dwight After Daryl's Escape?
- Madonna's New Twins Singing 'Twinkle Twinkle Little Star' Are Just Too Cute
- Report: Louis Tomlinson Rekindles Romance With Eleanor Calder Two Years After Split


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Thanks very much for checking out the Beta Version of Live Scores!
Obviously this is still in a developmental phase, but we're working hard to put things right so that you can enjoy the best live coverage of your favourite leagues.
Bear with us, it'll be worth it!
AMSTERDAM, NETHERLANDS - NOVEMBER 19: Macnelly Torres of Colombia during a FIFA Friendly match between Colombia and Netherlands at Amsterdam Arena on November 19, 2013 in Amsterdam, Netherlands. (Photo by Scott Heavey/LatinContent/Getty Images)


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Megan is a long haired tricolour female. Her date of birth is unknown but we estimate it to be May 2014. Megan is another cat that was rescued following a car accident and brought to us after recovering at the vets. She shuns the company of other cats but loves human attention.
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Miners reject Lonmin pay offer
South African miners rejected a pay offer from Lonmin that would have seen workers get at least 5,550 rand (£413) a month, far less than the 12,500 rand demanded by strikers. But Lonmin shares bounced along with the rest of the mining sector as stock markets took heart from the US decision to try to boost growth with QE3.
Eads hits back at merger 'snipers'
Eads, the owner of Airbus, has attacked critics of its proposed £30bn mega-merger with the UK defence giant BAE Systems as "anonymous snipers". The political aspect has worried the markets since the deal was announced. Shares in BAE and Eads were badly hit, although the UK group recovered yesterday.
UK sees better construction figures
A shallower than feared decline of 3 per cent for Britain's builders between April and June looks likely to see growth estimates for the UK economy lifted again in the second quarter. Analysts said the better construction figures meant the UK was likely to have shrunk by 0.4 per cent instead of 0.5 per cent.
Timeweave spurns Joe Lewis offer
Joe Lewis, the billionaire owner Tottenham Hotspur, suffered a setback yesterday when Timeweave rejected his £50m bid to acquire the horseracing broadcaster. Timeweave, which holds licences with 34 courses to televise races in betting shops, said the offer of 22p a share "fails to reflect fully the value" of the company.Reuse content


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"While Islam is projected today as inimical and hostile to Christianity, Judaism and other Religions, the truth is that the Prophet was the great educator, teaching people the meaning and explanation of their own Religion, correcting and assisting them in following the right path, as taught by previous Prophets and messengers."
Related quotes
""In the beginning was the Word, and the Word was against God, and the Word was God. " "With." is derived from old English "against.""
"If I had to baptize a Jew, I would take him to the bridge of the Elbe, hang a stone around his neck and push him over with the words "I baptize thee in the name of Abraham""
"For thou, o Lord of hosts, God of Israel, hast revealed to thy servant, saying, I will build thee an house: therefore hath thy servant found in his heart to pray this prayer unto thee. (2 Samuel 7:27)"
"He trusted in the Lord God of Israel; so that after him was none like him among all the kings of Judah, nor any that were before him. (2 Kings 18:5)"
"The careful reader of the New Testament will find three Christs described: - One who wished to preserve Judaism - one who wished to reform it, and one who built a system of his own"


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Each month, direct to your email inbox, we'll send the best camping news, tips, recipes and more, to enhance the camping lifestyle that you love so much. Learn More
No matter the time of year or the weather these TV shows and movies are sur...
In the unfortunate event you get your rig caught in a tough spot, these tip...
These tips will have you crafting campfire tales like a pro.
Plan the perfect trip from home or on the road with the official KOA app. Learn More
Open April 20 - October 20
Reserve: 800-562-9395
Info: 450-763-5625
171 Route 338
Coteau-Du-Lac, QC J0P 1B0 CanadaGet Directions
Located at Exit 17 from Hwy 20. Easiest access to downtown Montreal and Hwy 401. From Hwy 20: Take Exit 17 to Route 338 West. From Valleyfield Road: 132 west to 201 North turn right to Route 338 East. From Ottawa 40: Take 201 South. Turn right on 338 West.Get Google Directions
Camper Rating 4 out of 5


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Apple Pie Filling For Pie Or Tarts
|4 Cup (64 tbs), peeled thin
|1 Teaspoon
|1 Teaspoon
|Vanilla extract
|1 Teaspoon
|Lemon juice
|2 Teaspoon
|Lemon peel
|1 Teaspoon, grated
Put the apple slices into a large non-stick pan that has been coated with non-stick cooking spray.
Cover and cook for about 10 minutes.
Stir occasionally.
When the apple slices are soft, add the remaining ingredients and stir to mix.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 557 Calories from Fat 30
% Daily Value*
Total Fat 4 g5.4%
Saturated Fat 1.6 g7.9%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 11.8 mg0.5%
Total Carbohydrates 141 g47.1%
Dietary Fiber 27.3 g109.2%
Sugars 102.4 g
Protein 3 g6.2%
Vitamin A 10.9% Vitamin C 92.6%
Calcium 12.5% Iron 9.8%
*Based on a 2000 Calorie diet


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Is Emmanphil Manpower Services incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Philippines provides information regarding Emmanphil Manpower Services in Quezon City Metro Manila. Emmanphil Manpower Services is located at 30 Lot 35 Mabini Street, Quezon City Metro Manila 1123 and provides Employment Agencies services. Contact them on (02) 417 2009.
Is Emmanphil Manpower Services in 30 Lot 35 Mabini Street, Quezon City Metro Manila 1123 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
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Lot 7 Hearthstone UNIT 7,Horse Shoe NC, 28742
Status: Active
Berkshire Hathaway HomeServices Lifestyle Properties
(828) 233-1150
Last Updated: 2/27/2017 7:19 AM
Description for Lot 7 Hearthstone UNIT 7 Horse Shoe, NC 28742
Peaceful natural wooded setting with wildflowers, rhododendrons, etc. Restricted subdivision with city water, natural gas, paved roads and underground utilities. co-listing broker is officer of selling corporation.
Listing Information
No Sewer
School Information
Room Information
Exterior / Lot Features
Greater Than 1 Acre
Driving Directions
FM H'Ville, Brevard Rd (Hwy 64) west to left on Battle Creek Rd (just past S Rugby), left into Hearthstone, lot on left just past 1st house.
Financial Considerations
Inside AccessTM
Current market conditions for Lot 7 Hearthstone UNIT 7
Active Market Trends
Source:MLS DATA
Median list price$249,900
Days on market66
Properties for sale9
Sold Market Trends
Source:MLS DATA
Median sold price$234,000
Sales to list price9,575.0%
Properties sold4
Median sq ft price$159
Arrows indicate 90 day trend
Listing Price History for Lot 7 Hearthstone UNIT 7
Horse Shoe Real Estate
Horse Shoe is located in North Carolina. Horse Shoe, North Carolina 28742 has a population of 2,770.
The median household income in Horse Shoe, North Carolina 28742 is $67,171. The median household income for the surrounding county is $46,503 compared to the national median of $53,046. The median age of people living in Horse Shoe 28742 is 49.8 years.
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Berkshire Hathaway HomeServices Lifestyle Properties
(828) 233-1150
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Be Vewy, Vewy Quiet
- The bug where your username was randomly replaced by someone else's is fixed according to a few readers.
- I am aware that the site gets shoved down the page in IE 6 and am attempting to fix it; give me a week or so.
- I'm also trying to fix the flyout menus showing up under flash content.
- I know the tabs look weird for some, but it's been really hard to track down why because it's been intermittent.
- The recruiting board has been ported over. It now lives under "useful stuff" on the nav menu.
- I am not enthralled with everything yet but I wanted to get the site live so I could spend July working out kinks instead of August or September. If you have suggestions I am open to them.
Update: Forgot one bug in the queue: anonymous comments are apparently getting registered -- they bump up the comment count -- but not displayed.
The only thing bugging me so far is that the Fanhouse links aren't on (yet?). Honestly the only time I'll go there is if a link in the sidebar catches my eye.
Other than that, it's gravy.
WAHOO! GRAVY- My favorite beverage!!!!!
/Charlie Weis
(Sorry, but that one never gets old to me)
Wow, if there are this many diary entries already, I can't imagine what September is gonna look like. Anyone care to wager an over/under on the number of new diaries after the first game?
Also, why does the spam filter think this comment is spam?
now, nice & new. i thought i'd change the name a bit to
- protect
- the
- innocent.
Although not the best photoshop job, I just thought I would offer this as it fits the theme.... Until the banner contest is settled of course...
Do with it what you will. All the "space bitches" talk inspired it.
Looks like the Yardbarker ad issue has been fixxored. Wahoo!
And Brian, thanks for the updated site man- on a scale of one to ten, it rates a "Girls making out".


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the EVOLVE is the one of the first full turbo back Exhausts available for the 2013 Hyundai Genesis Coupe 2.0T
3.8 Hyundai Genesis Coupe Ark GRiP / Stock Exhaust Comparison
Please note: R2C intake installed for both configurations. GRiP includes H-pipe (secondary cat delete). Start up and in-cabin road test. A good portion of the in-cabin sound comes from the R2C.
2015 Hyundai Genesis Coupe 3.8 with Flowmaster 80 exhaust and tips before and after
My 2015 Hyundai Genesis Coupe 3.8 with Flowmaster 80 Exhaust and tips. This is a before and after. The Exhaust is a flowmaster 80 part 42583 and flowmaster 15369 tips. Is a lot louder after installation. The whole set up with installations cost about $230. This is a axle back install only. No other modifications to car or Exhaust.


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Welcome to our new website!
The time has come for us to find our place on the world wide web! We have been working on creating a website for most of 2008 and are happy to finally be up and running, although incomplete as yet....
You will notice quite a bit of our 'envisioned' site is still under construction, but it won't be long until all the blanks are filled in for your benefit!
For now, the "Our Products" link will be a great tool for you to check our supply of 'in stock' hay, straw, bedding etc, with prices to be updated on a daily basis. This page will eventually feature all of our most popular and in demand products available in the Feed Store.
We have recently been very surprised to discover that many locals had the impression we only delivered hay by the truckload. Of course we do provide that service as required, but also sell from our stock on hand any amount needed from one bale to hundreds! Our new Vanderveen slogan is "One Bale, One Ton, One Trailer." HAY WHERE QUALITY COUNTS..!
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