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Membrane fusion at neuronal synapses is a highly regulated process that is triggered by micromolar concentrations of calcium in the presynaptic cell. The SNARE proteins drive fusion and form the critical core of the fusion machinery;however, they are not directly regulated by calcium. Synaptotagmin 1 is a vesicle associated membrane protein that functions as the calcium sensor in neuronal exocytosis. It is anchored by a single transmembrane segment at its N-terminus and contains two C2 domains that have been shown to bind membranes in a calcium-dependent fashion. Synaptotagmin also interacts with SNAREs. At the present time, the nature of the synaptotagmin interactions that mediate fusion are not understood. The proposed work will utilize evolving magnetic resonance methods, such as site-directed spin labeling and pulse EPR, to evaluate a number of proposed mechanisms for the molecular function of sytnaptotagmin.
The specific aims are to test the importance of a bridging conformation that is observed for synaptotagmin 1, where the two C2 domains bind opposing bilayers. Proposed experiments will test the hypothesis that synaptotagmin 1 switches from SNARE to membrane interactions in the presence of calcium, and both membrane and SNARE associated structures for synaptotagmin 1 will be generated.
A final aim will examine the effects of synaptotagmin 1 on lipid bilayer properties and test the role of these effects in mediating membrane fusion. Membrane fusion is central to cellular processes such as intracellular transport, host defense (killing of microorganisms, immune response), and human physiology and disease (e.g., glucose regulation/diabetes, allergic response). Calcium -triggered neuronal fusion is a central process in neurobiology and it underlies synaptic transmission and potentiation. Regulated neuronal exocytosis is thought to be relevant to an understanding of schizophrenia, bipolar disorder, Huntington's disease, Parkinson's disease, Alzheimer's disease as well as range of other neurological disorders.
The proposed work is directed at characterizing the molecular mechanisms by which neurons release neurotransmitters and communicate with each other in the central nervous system. The mechanisms of neurotransmitter release are relevant to understanding a wide range of neurological disorders, including schizophrenia, bipolar disorder, Huntington's disease, Parkinson's disease and Alzheimer's disease.
|Moissoglu, Konstadinos; Kiessling, Volker; Wan, Chen et al. (2014) Regulation of Rac1 translocation and activation by membrane domains and their boundaries. J Cell Sci 127:2565-76
|Park, Yongsoo; Vennekate, Wensi; Yavuz, Halenur et al. (2014) ?-SNAP interferes with the zippering of the SNARE protein membrane fusion machinery. J Biol Chem 289:16326-35
|Liang, Binyong; Dawidowski, Damian; Ellena, Jeffrey F et al. (2014) The SNARE motif of synaptobrevin exhibits an aqueous-interfacial partitioning that is modulated by membrane curvature. Biochemistry 53:1485-94
|Hernandez, Javier M; Kreutzberger, Alex J B; Kiessling, Volker et al. (2014) Variable cooperativity in SNARE-mediated membrane fusion. Proc Natl Acad Sci U S A 111:12037-42
|Cafiso, David S (2014) Identifying and quantitating conformational exchange in membrane proteins using site-directed spin labeling. Acc Chem Res 47:3102-9
|Dawidowski, Damian; Cafiso, David S (2013) Allosteric control of syntaxin 1a by Munc18-1: characterization of the open and closed conformations of syntaxin. Biophys J 104:1585-94
|Kiessling, Volker; Ahmed, Saheeb; Domanska, Marta K et al. (2013) Rapid fusion of synaptic vesicles with reconstituted target SNARE membranes. Biophys J 104:1950-8
|Honigmann, Alf; van den Bogaart, Geert; Iraheta, Emilio et al. (2013) Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol 20:679-86
|van den Bogaart, Geert; Meyenberg, Karsten; Diederichsen, Ulf et al. (2012) Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. J Biol Chem 287:16447-53
|van den Bogaart, Geert; Thutupalli, Shashi; Risselada, Jelger H et al. (2011) Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nat Struct Mol Biol 18:805-12
Showing the most recent 10 out of 40 publications

subset: commoncrawl


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$5.00 Sale: $4.24
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This is one more DT LO for Scraps of Darkness June's Kit ""White Rabbit", featuring &Dots Wonderland Collection Paper.
I have chosen this photo, as I like that my DD and DH are more than a parent and a kid, but are friends. I like to watch how they are playing and enjoy each other.
for more details and close ups, please visit my blog
$4.99 $2.78
$5.00 $4.24
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STARmeterSEE RANK
Up 370,242 this week
Jonathon Culver
Jonathon Culver is trained in Shakespearean theatre from an early age, also trained in stunt work, improv, and stage combat. His first starring role on stage was as Bat Boy, in the play of the same name. He was first cast as principal for the camera in the web-series, "Sharp Cooking". He had a starring role in the award-winning short movie, "The ... See full bio »
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text: Across the globe, animal lovers were united in outrage this week, following the euthanization of a dog in Northern Ireland. A two-year international campaign to save Lennox, an American Bulldog/Labrador mix with no history of aggression or behavioral issues, ended on Wednesday with the announcment from City Council officials that the 7-year-old dog had been killed. Lennox's life was cut short not because of any unsavory deed or dangerous act that he had committed, but solely because of his appearance.


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2016 Lumity Health Care and Science Scholarship
For years, it has been Lumity's goal to naturally tend to aging skin with an ideal balance of vitamins, minerals and our unique proprietary complexes. Over time, anyone can feel confident with the way that they look and feel. Lumity's products contribute to collagen and elastin formation, clear out toxins, repair oxidative damage, protect your DNA, revitalize cell energy centers and stimulate the release of HGH (human growth hormone). Skin enhancement is a popular topic in health care, and Lumity is an essential part of that discussion.
Lumity is excited to sponsor the 2016 Health Care and Science Scholarship to currently enrolled college students participating in educational programs involving Health Care, Dermatology, Nutrition or Science.
Featuring a $1,000 grand prize and a runner-up $500 award, the Health Care and Science Scholarship will be accepting applications from current students attending an accredited college or university in the United States. Any student interested in participating should submit a copy of their current transcript as well as an answer to the essay question provided below. Applicants will be judged on their academic merits and the content of the application essay they provide.
1st place: $1,000
Runner-up $500
Essay Question
Besides helping others, what intrigued you to take college courses related to the health care field?
- Applicants must be a current student at an accredited college or university within the U.S.
- Applicants must have a minimum 2.8 GPA.
- Applicants must submit a copy of their transcript.
How to Apply
To apply for the 2016 Lumity Health Care and Science Scholarship, please fill out our online application and submit your essay and most recent academic transcript using the web form. All applications must be received by July 1st 2016. Winners will be announced and notified by August 1st 2016.


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Is Southern Stampede incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog NewZealand provides information regarding Southern Stampede in Queenstown. Southern Stampede is located at 29 Park Street, Queenstown and provides Ice services. Contact them by visiting them on their website http://www.southernstampede.co.nz.
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Want Cable? Get XFINITY TV in Coldwater, MS
XFINITY TV from Comcast has a variety of affordable TV packages to suit everyone in Coldwater, MS. You can count on XFINITY TV for tens of thousands of On Demand choices, versatile DVR packages, and digital cable channels.
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Duke of Burgundy (Character)
from "Joan of Arc" (1999)
Alternate Names:
FilmographyEdit Credits
- Shakespeare's Globe: Henry V (2013) Played by Paul Rider
- "The White Queen"
- The Price of Power (2013) TV episode, Played by Joren Seldeslachts (as Charles of Burgundy)
- "The Hollow Crown"
- Henry V (2012) TV episode, Played by Richard Griffiths
- Joan of Arc (2003) (TV) Played by Vladimír Marek
... aka "Johanka z Arku" - Czech Republic (original title)
- The Messenger: The Story of Joan of Arc (1999) Played by Michael Jenn (as The Duke of Burgundy)
... aka "Joan of Arc" - France (original title)
- "Joan of Arc" (1999) TV series Played by Jaimz Woolvett
- Henry V (1989) Played by Harold Innocent (as Duke Philippe of Burgundy)
- Henry V (1979) (TV) Played by Robert Harris
... aka "The Life of Henry the Fift" - UK (original title)
... aka "The Complete Dramatic Works of William Shakespeare: Henry V" - USA (video title)
- Henry V (1944) Played by Valentine Dyall
... aka "The Chronicle History of King Henry the Fifth with His Battell Fought at Agincourt in France" - UK (original title)
... aka "Henry the Fifth" - UK (short title), USA (trailer title)
- Joan the Woman (1916) Played by Hugo B. Koch
Additional Details
Plot Keywords:
Fun Stuff
The Duke of Burgundy: [to Joan] Personally, I don't believe in God. I don't believe in the Devil either. Perhaps that is why I am never disappointed. See more »
You may correct errors and omissions on this page directly. Clicking the 'Update' button will take you through a step-by-step process.


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Phymanthus crucifer
|Phymanthus crucifer
|Scientific classification
|P. crucifer
|Binomial name
|Phymanthus crucifer
(Le Sueur, 1817)
Epicystis crucifer (Le Sueur, 1817)
Phymanthus crucifer, commonly known as the rock flower anemone, flower anemone, red beaded anemone[1][2] or the beaded anemone,[3] is a species of sea anemone in the family Phymanthidae. It has been described as "closely similar" to Heteractis aurora in several ways, commonly exhibiting "tentacles with swollen cross-bars"[4] bearing large clusters of stinging nematocysts.[5] However, P. crucifer may also be found with smooth tentacles, sometimes in the immediate vicinity of a swollen-crossbarred specimen.[4]
The disk, flat and edged with about 200 short tentacles, may grow to 15 centimetres (5.9 in) across.[3] The column, fully extended, may reach 15 to 20 centimetres (5.9 to 7.9 in) in length with a diameter of 51 to 76 millimetres (2.0 to 3.0 in) in large individuals; however, most individuals have only half this length and diameter.[5] P. crucifer exhibits a high degree of colour variability, ranging from sandy or buff to dull green or even red. The base of the column is generally cream-coloured with streaks of red, greying towards the top.[5] Rows of light and dark stripes and bumps radiate outward from the mouth,[3] varying in colour from bright green in the centre to brown, lavender, yellow, or white going outwards.[5] It has bright red suckers on its column, to which debris can attach for camouflage.[5]
P. crucifer inhabits the sandy bottoms of the Caribbean Sea and can be found across the West Indies.[5] The main part (column) of the anemone is usually buried in the sand, anchored to a rock below the surface, so that when disturbed the anemone can pull back into the substrate.[3] Documented as a species often associated with coral reefs[6] and rocky ledges, P. crucifer is able to withdraw into crevices and holes if agitated.[5]
The reproductive cycle in this species has been observed to be prolonged (longer than annual or biannual), suggesting differences between the reproductive cycles of tropical sea anemones and those of cooler water anemones.[7] P. crucifer can reproduce sexually, with the eggs developing into larvae inside the parent.[7] P. crucifer is a dioecious species, having distinctly male and female individuals and large eggs.[7]
- ^ a b "Phymanthus crucifer". Integrated Taxonomic Information System. Retrieved 9 June 2010.
- ^ "Phymanthus crucifer". Smithsonian Tropical Research Institute. Smithsonian. Retrieved 9 June 2010.
- ^ a b c d Kaplan, Eugene H. (1999). Roger Tory Peterson, ed. A Field Guide to Coral Reefs: Caribbean and Florida. Peterson Field Guide. 27. Houghton Mifflin Harcourt. p. 75. ISBN 0-618-00211-1.
- ^ a b Hartog, J C den (1987). "Notes on the genus Amphiprion Bloch & Schneider, 1801 (Teleostei: Pomacentridae) and its host sea anemones in the Seychelles". Zoologische Mededelingen. 61: 405–419. Retrieved 9 June 2010.
- ^ a b c d e f g Verrill, Addison Emery (April 1907). The Bermuda Islands: Volume 1. Supplement to the second edition. Transactions of the Connecticut Academy of Arts and Sciences. New Haven, Connecticut: Connecticut Academy of Arts and Sciences. pp. 229–230. Retrieved 10 June 2010.
- ^ Garese, Agustín; Héctor M. Guzmán; Fabián H. Acuña (December 2009). "Sea Anemones (Cnidaria: Actiniaria and Corallimorpharia) from Panama". Revista de biología marina y oceanografía. 44 (3): 791–802. doi:10.4067/S0718-19572009000300025. Retrieved 9 June 2010.
- ^ a b c Lin, Ming-Doun; Chaolun Allen Chen; Lee-Sing Fang (2001). "Distribution and Sexual Reproduction of a Seagrass-bed-inhabiting Actiniarian, Phymanthus strandesi (Cnidaria: Anthozoa: Actiniaria: Phymanthidae), at Hsiao-Liuchiu Island, Taiwan" (PDF). Zoological Studies. 40 (3): 254–261. Retrieved 9 June 2010.


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Canberra City Gymnastic ClubSports Gymnastics Centres
85 Chandler St, Belconnen, ACT 2617
Best match results for: CATEGORY = Gymnastics Associations for Kids + LOCATION = the Belconnen Region
Results include related kids activities and neighbouring locations.
Gymnastic activities for kids in the Belconnen Region
85 Chandler St, Belconnen, ACT 2617
Gymnastic activities for kids around the Belconnen Region
Unit 4, 4 Dacre Street, Mitchell, ACT 2911
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Erindale Active Leisure Centre, McBryde Crescent, Wanniassa, ACT 2903
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Servicing Bruce, Belconnen, Evatt and 28 other suburb(s)
This business can travel to you.
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From 08-04-2017 To 23-04-2017
Having fun, developing motor skills and coordination whilst learning to play soccer in a friendly and welcoming environment.
From 19-02-2017 To 17-12-2017
Kids Football Club runs development programs for children aged 3 - 12 years. We're really good at making young children feel comfortable in a sports environment and getting them to engage in their activities. Programmes ...
Baldwin Drive, Kaleen, ACT 2617
Cnr Bindubi St & Belconnen Way , Sainsbury & Walford Memorial Diamond , Aranda, ACT 2614
PO BOX 477, Belconnen, ACT 2617
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AIS Combat Centre, Leverrier Crs, Bruce, ACT 2617
100 Eastern Valley Way, Belconnen, ACT 2617
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College St, Bruce, ACT 2617
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Banambila St, Aranda, ACT 2614
100 Eastern Valley Way, Belconnen, ACT 2617
Birie Pl, Kaleen, ACT 2617
PO BOX 7039, Kaleen, ACT 2617


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Web portal LadyPraha
beauty, health and sports in Prague
Beauty salons, hair salons, nail studios, massage and much more
Video of the week
Recent site activity
Information for beauty salons and trainers!
Welcome to LadyPraha!
Our goal is to create the most convenient and comprehensive website that brings together masters and customers, it helps to increase the number of your visitors and improve your ranking among the customers.
We offer FREE and PAID services.
- registration and adding of any text, photo, and video information about your salon, fitness center, master or trainer.
- adding of your discounts and promotions.
- any announcements about searching for staff, equipment, facilities, sales of cosmetics, and others subjects related to our site.
- adding to TOP-salons and TOP-discounts (display of your services in the top five on the pages of the site)
- advertisement for your services (article about you, blocks and banners), which will increase your salons views and attract even more customers to you.
Advantages of LadyPraha among other similar portals:
- Our portal works in three languages. The target audience LadyPraha consists of Czech, Russian and English customers, so the information you post about your salons will be available to the maximum number of your potential customers: Czech, Russian people and other foreign tourists who wish to find a suitable beauty salons, private master or trainer.
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- Using LadyPraha you can also advertise your services on the Internet, share any news of your organization. We are open to advertising and commercial offers to promote your salons and services.
- We love and appreciate every customer. Therefore, we have tried to make our portal as user-friendly, enjoyable and intelligible as possible. Join LadyPraha!


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Joanne Y. Cleaver
Photo: shutterstock.com
Real estate agents like to say that house hunters make offers based not on price, but emotions. Recently, Duke University published scientific research that supports the reality of such a phenomenon.
Whether you're buying or selling a home, even a rudimentary understanding of how the brain synthesizes emotions can help you develop (and stick to) a logic-based valuation of the property in question.
Related: What's My House Worth?
Let's say that after 25 happy years, you're putting the family home on the market. When you look at the place from the curb, you see holiday memories and the hard-won result of your maintenance and remodeling efforts.
Indeed, fond associations may lead you to view the property in more favorable economic terms than it warrants. But you can't put a price on memories. For a fair assessment of the home's market value, seek out a third-party appraisal.
Remember also that emotions figure largely in the real estate negotiation process, no matter which side of the table you are sitting on. And in the heat of the transaction, small incentives can deliver outsize impact.
If you are selling, hold back on a small concession, such as a $500 allowance for new carpeting. Once you are close to reaching an agreement, toss that incentive into the mix, as it might help your buyer feel more comfortable accepting the terms.
Conversely, if you are negotiating to buy, carefully monitor your own emotional response to the tactic described above. Don't let your emotions attach an outsize value to the incentive. Ask yourself whether it's truly enough to make you agree to the sale price.
Duke researchers found that for human beings, emotions inevitably factor into valuations. The best you can do is to be aware of your own tendency toward irrationality, working around it by focusing on facts.
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Suncast SC2700 20-Inch Snow Shovel/Pusher Combo with Wear Strip And D-Grip Handle
Holiday Wonderland 100-Count Clear Christmas Light Set
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BEIRUT A group of powerful rebel brigades in northern Syria is struggling to defuse an armed standoff pitting insurgents against an al-Qaida affiliate for control of a strategic town near the Turkish border.
The conflict over Azaz has shuttered a Turkish border crossing long used to supply the rebel movement and heightened tensions between rebels who seek the ouster of President Bashar Assad and extremists who want to found a transnational Islamic state.
The al-Qaida group, the Islamic State in Iraq and Syria, known as ISIS, routed rebels to take control of Azaz two weeks ago. Rebels who oppose the ISIS jihadists have collected forces at the Bab al-Salameh border crossing a few miles away. Turkey has kept the crossing closed since Sept. 19 because of security concerns, a Turkish Foreign Ministry official said.
Seeking to end the crisis, a group of six rebel brigades released a statement Wednesday calling for a cease-fire.
It told the ISIS jihadists not "to shed the blood of Muslims and be hasty in calling them heretics and apostates." It also called on both sides to submit themselves to the Sharia Commission, a rebel-run court in the northern city of Aleppo, within 48 hours to resolve the problem.
It was unclear if the ISIS would heed the call.
While many insurgents are deeply Islamist, their focus remains on toppling Assad, and they accuse ISIS of prioritizing its own jihadist agenda. But the rebels hesitate to confront ISIS, saying their resources are already stretched by fighting the government.
ISIS seized Azaz from a local group known as the Northern Storm that led the fight last year to oust government forces. A Northern Storm commander reached by phone said ISIS has since attacked his group in nearby villages and that his fighters were shooting back with heavy machine guns meant to down airplanes.
"This is all we can do until we find a way to end this," said the commander, known as Abu Yamen.
This week, an al-Qaida spokesman accused the Northern Storm of attacking first and said the rebel group had struck a deal with Sen. John McCain, R-Ariz., during a visit to Syria earlier this year to fight against ISIS "and hit the mujahedeen."
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Ford's 2015 Ford F-150 is a technological tour-de-force, what with its aluminum-intensive construction and its powerful and efficient new 2.7-liter EcoBoost engine option. But now that it's hit the market, it's time to get down to brass tacks and find out how just the latest F-150 actually stands up to its rivals in the hyper-competitive fullsize segment.
2014 Ram 1500 Diesel
Ram 1500 bests new F-150 in MT pickup shootout
- Chris Bruce
- Nov 25, 2014
Chrysler 3.0L EcoDiesel V6: Autoblog Technology of the Year finalist
- Jeremy Korzeniewski
- Nov 19, 2014
Offering a diesel engine in an American pickup is anything but new – Ford, General Motors and Chrysler all offer excellent and almost impossibly powerful oil-burning engines in their various fullsize trucks. What is new and novel about the 3.0L EcoDiesel, though, is its size, and the variety of vehicles that use it. It's the smallest engine, as far as displacement is concerned, currently offered in a large truck in the US, and, for 2014 and 2015, it is available in the Ram 1500 and the Jee
Weekly Recap: Ram doubles down on diesels
- Greg Migliore
- Oct 4, 2014
Chrysler now expects about 20 percent of Ram 1500s will be sold with the EcoDiesel engine for the 2015 model year.
Consumer Reports says Ram 1500 tops fuel economy fight [w/video]
- Sebastian Blanco
- Aug 27, 2014
Consumer Reports takes its independent vehicle testing procedures seriously. In an era when we have to question the EPA's official ratings thanks to recent re-evaluations from Ford and Hyundai, an independent voice is important. So, when CR says something is the best, it's worth paying attention to.
Ram pickups to keep it steel through 2020
- Chris Bruce
- Aug 22, 2014
One of the hottest topics in the industry these days is automakers' expanding use of aluminum, especially for vehicle bodies and platforms. While the lightweight metal has historically been the preserve of premium brands and sports cars, Ford shocked the industry when it announced that its 2015 F-150 would go aluminum-intensive for its new generation. As it turns out, the material change doesn't even mean a big jump in the prices for most of its trims. Possibly in reaction to the big change, Gen
Ram and Fiat Professional announce plans for new trucks, vans starting in 2015
- Jonathon Ramsey
- May 6, 2014
Ram Trucks CEO and President Reid Bigland got his turn among the executives elucidating the near-term futures for brands in the Fiat Chrysler Automobiles umbrella, laying out the plans for both Ram trucks and Fiat Professional. After Bigland said that the company "will continue to invest heavily in commercial vehicles" for the Italian arm, he didn't give many specifics as to where that investment would go. What we do know for now is that a new Fiat Doblo will come next year - that's the truck we
Chevy ramping Silverado incentives after Ram beats it in March
- Chris Bruce
- Apr 5, 2014
General Motors isn't losing the pickup war without a fight. With the Silverado narrowly falling to third place in the truck segment in March, Chevrolet has announced that it is going to continue its Truck Month pricing through the end of April. In addition to those incentives, some Chevy pickups are going to see even deeper discounts, according to Automotive News.
Did Ram outsell Chevy Silverado for first time in history last month?
- Chris Bruce
- Apr 2, 2014
Recently released automotive March sales figures point to a major shakeup in the pickup world. Last month, Ram's trucks overtook the Chevrolet Silverado to become the second-best selling vehicle in the segment for the first time ever.
Ram/Jeep Ecodiesel engine has Maserati roots
- Jonathon Ramsey
- Mar 16, 2014
The 3.0L turbodiesel V6 in the 2014 Ram 1500 EcoDiesel earned a slot on Ward's Automotive 2014 10 Best Engines for its power, fuel economy and refinement. In a piece looking at how Fiat subsidiary VM Motor developed the engine, Ward's also makes note of the fact that the same lump goes in diesel versions of the Maserati Quattroporte and Ghibli. They're tuned a bit differently, naturally, with the QP putting out 275 horsepower and 442 pound-feet of torque, the smaller, lighter Ghibli making do wi
Chrysler flooded with over 8,000 Ram 1500 EcoDiesel orders in 3 days
- Chris Bruce
- Feb 19, 2014
The diesel, half-ton pickup has long been a Holy Grail to many truck fans, largely because of its potential to achieve both high payload and great fuel economy. Strange, then, that auto companies have seemingly been slow to react. However, Chrysler is finally wading into the pool for the 2014 model year with a version of its Ram 1500 pickup, and early claimed returns are showing the advantage of being first on the market. The Auburn Hills automaker has just revealed that its initial allocation o
2014 Ram 1500 EcoDiesel nets car-like 28-mpg rating
- Chris Paukert
- Feb 4, 2014
Not long ago, 28 miles per gallon would have been a perfectly fantastic highway fuel economy rating on the window sticker of a midsize sedan, and here we are just a few years later, with a fullsize pickup laying claim to the very same number. According to Chrysler, the EPA has certified its 2014 Ram 1500 with 3.0-liter EcoDiesel V6 at that lofty number – a figure, not incidentally, that's better than anything available from the industry's midsize trucks. The drop-shouldered pickup gets a c
Ram 1500 Motor Trend's first back-to-back Truck Of The Year
- Brandon Turkus
- Dec 4, 2013
For the first time ever, Motor Trend has named a back-to-back winner of its Truck of the Year competition, handing the crown to last year's winner, the Ram 1500. Ram's entry to the pickup battle bested a range of new or heavily improved models, including its big brothers, the Ram Heavy Duty and Ram ProMaster van.
Ram thinks EcoDiesel will lure small-pickup buyers into fullsize 1500
- Pete Bigelow
- Nov 21, 2013
One of the more curious developments at the Los Angeles Auto Show this week was the return of the Chevrolet Colorado pickup truck. General Motors ended production of the Colorado and its cousin, the GMC Canyon, early last year. At the time, the decision seemed to be the final curtain for small and midsize domestic pickups, as it followed Ford's decision to kill the Ranger and Chrysler's decision to end production of the Dodge Dakota.
2014 Ram 1500 named Truck of Texas, Chrysler Cleans Up at Truck Rodeo
- Jeffrey N. Ross
- Oct 14, 2013
Trucks are king in Texas, so the annual Truck of Texas awarded by the Texas Auto Writers Association gives automakers big bragging rights. This year's Texas Truck Rodeo featured 63 trucks, crossover and SUVs, and the 2014 Ram 1500 took home the prestigious Truck of Texas, giving the pickup back-to-back wins for this award. The good news didn't stop there for Chrysler Group, as Ram, Dodge and Jeep dominated most other categories, accounting for 15 of the possible 24 awards.
2014 Ram 1500 Diesel
- Jonathon Ramsey
- Sep 26, 2013
Remember when Mahindra & Mahindra was close to offering a compact diesel pickup here? A million voices from the truck-and-bed-loving tribes of the Internet cried out at once in anticipation, only to be silenced in disappointment when it didn't happen. And this was for a jitney with a bed that didn't exactly look robust in its press photos. The message these fans had was clear: light-duty truck + a diesel engine = a prayer answered for a significant contingent of truck buyers.
- Biggest automotive sales disappointments
- Fastest-depreciating cars in the United States
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html website conversion of wordpress website needed
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Your search returned 109 cottages.
- Sleeps5
- Bedrooms3
- PetsYes
Charming barn conversion in a village location. Open fire, WiFi, conservatory. Two mins stroll from the pub. Ulverston 3 miles. (Ref. 918749)
7 nights from £286Find out more
- Sleeps2
- Bedrooms1
- PetsNo
Charming semi-detached wing of the owner's cottage in the centre of Great Urswick in Cumbria. Romantic getaway. Open plan accommodation. Ulverston 3 miles. (Ref. 9837)
7 nights from £248Find out more
- Sleeps14
- Bedrooms6
- PetsNo
Spacious family cottage in Bardsea. Grounds of country house with use of facilities available. Private hot tub and wood-fired sauna. Use of woodland grounds. Ulverston 1 mile. (Ref. 13570)
7 nights from £1013Find out more
- Sleeps25
- Bedrooms13
- PetsNo
A stunning Edwardian house in Bardsea with hot tub, sauna, woodburner, WiFi, en-suite bedrooms, mature grounds. Close to Ulverston, coast and Lake District National Park. (Ref. 918339)
7 nights from £2910Find out more
- Sleeps6
- Bedrooms3
- PetsNo
Superb large contemporary cottage on the east coast close to Ulverston. Stunning coastal sea views and sunsets. Large luxury kitchen/diner and orangery with wrap around gardens. Ulverston 8 miles. (Ref. 933082)
7 nights from £460Find out more
- Sleeps6
- Bedrooms3
- PetsYes
Immaculately-presented Cumbrian cottage on the stunning Morecambe Bay coast close to Conishead Priory. Woodburning stove. Pet-friendly. Ulverston 2 miles. (Ref. 17105)
7 nights from £343Find out more
- Sleeps5
- Bedrooms3
- PetsNo
Cosy detached cottage 1 mile from Roa Island. Quality accommodation, furnished to a high standard. Sea views. Excellent touring base for South Lakes. Ulverston 6 miles. (Ref. 1383)
7 nights from £289Find out more
- Sleeps3
- Bedrooms2
- PetsYes
Charming Grade II listed 17th century terraced cottage in the market town of Dalton-in-Furness. Period fireplace and original floor boards. Pet-friendly. Close to lovely historic pub and pele tower. Private seating area. Ulverston 5 miles. (Ref. 940094)
7 nights from £254Find out more
- Sleeps6
- Bedrooms3
- PetsYes
Superb detached cottage in centre of Ulverston. En-suite facilities. Off road parking. Pet-friendly. Lake Windermere 12 miles. (Ref. 914672)
7 nights from £363Find out more
- Sleeps2
- Bedrooms1
- PetsNo
Immaculately-presented, superbly located detached cottage in Pennington. Woodburning stove, bright sunny patio. Ideal touring base for Lakes and coast. Ulverston 2 miles. (Ref. 27034)
7 nights from £265Find out more
Just show me Aldingham Cottages
Searching for a holiday home in the Lake District away from the usual tourist traps? Rent a cottage in Aldingham, an ancient coastal village overlooking Morecombe Bay. Within easy reach of the Lake District's postcard fens, as well as Cumbria's magnificent - and frequently overlooked - beaches, a cottage in Aldingham is a great base for a Cumbrian touring holiday.
Enjoy coast & country on an Aldingham cottage holiday
When you rent a cottage in Aldingham with Sykes, you can look forward to the very best of coast and country. Thanks to its location on Cumbria's south coast, Aldingham proves perfect for exploring the many beaches which scatter the shore, including Walney Island, Silecroft and of course, Aldingham. Though not frequented by sun-seeking tourists, these breath taking pockets of coast provide a playground for aquatic pursuits, not to mention the perfect place for walkies.
Head north from your Aldingham holiday cottage and you'll soon find yourself on the fringes of the Lake District National Park. Famed for its natural beauty, the Lake District is a dramatic destination, and one that visitors will never forget. If you're into walking, make for Grizedale Forest, a remarkable woodland on the banks of Windermere. Or, if you'd prefer to explore the Lakes' charming heritage towns, drive to Ulverston, Coniston or Kendal, where country pubs, independent shops and fascinating historic attractions await.
What else can you look forward to on an Aldingham cottage break? Discover the Lakes Glass Centre in Ulverston. Walk the Cumbria Coastal Way. Explore the Arnside Silverdale AONB. Eat Grasmere Gingerbread. Or simply relax and unwind in your Aldingham holiday cottage, basking in the peace and quiet Cumbria is renowned for.
Interested in renting a cottage in Aldingham? Scroll down to browse our collection of Cumbrian holiday rentals in and around this delightful village.


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- Reel Reviews: 2017 Oscar picks
- 'American Idiot' at EPAC
- Warwick grad producing 'Million Dollar Quartet' at Dutch Apple
- 'Somewhereville Station' revisits the 50s and 60s
- St. Patty's musical at Ephrata Main
- Dance, concert will benefit Jamaica missions
- Happy Anniver5ary, St. Boniface!
- Downtown diversity
- Travelogue will explore Colorado River this Saturday
Harting to perform in Christmas Day parade
Harting, along with 600 other performers chosen from across the country, traveled to Disney's Coronado Springs Resort at Walt Disney World Resort Dec. 5 through 8, to tape the parade.
The participants chosen are cheerleaders or dancers who qualified at one of NCA (National Cheerleaders Association) or NDA's (National Dance Alliance) summer camps across the country. Cheer participants had to receive an all-American award, Top Team award or Champion Chant award to qualify to attend. This select group represents the best all-around cheer and dance talent attending one of more than 400 NCA or NDA summer camps held each summer.
Neil Patrick Harris, Nick Cannon and Lara Spencer will host the special which includes performances by Mary J. Blige, Ne-Yo, Demi Lovato, Jordin Sparks and more.
The 30th annual holiday special will air nationwide Christmas morning at 10 a.m. on ABC television networks.


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Preheat oven to 350 degrees.
In a bowl, combine eggs and milk. Mix in stuffing, onion, parsley, salt and pepper. Add ground meats; mix well. Pat meat mixture into two greased 8-by-4-by-2-inch loaf pans.
Bake meatloaf uncovered in preheated oven 60 to 75 minutes or until internal temperature reaches 160 degrees. Remove from oven and spoon off excess fat.
In small bowl, combine ketchup, brown sugar and dry mustard; spread over meatloaves. Return to oven and bake an additional 10 minutes. Remove from pan and slice to serve.
Read and share your thoughts on this story.


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Royal Century Hotel
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A Universal truth
... transmit the complex motion of the performer's body (and face) to an animated character. We witnessed this first hand with one of the hosts and who started doing Drew Barrymore's famous 'Butt Dance' as a troll type creature on the screen behind him. See pictures to get a clearer idea of what we saw. When we left the studio we walked out into Springfield and all of our Simpsons dreams came true. Life size Moe's, Krusty Burger, Springfield Prison and Krustyland were ...
Dodgers and the Queen Mary
... and walked around the mall before going to see the movie The Water Diviner, the Australian Best Picture Winner, to round out the night.
Saturday: Saturday, was a very fun and busy day. Jordan, Ashley, Lydia, and I got up early and went into the mountains for a bit of hiking. It was super cloudy and a bit chilly, but the hike was really cool. We found a path that led to the top of Mount Lowe, (actually the same path Jordan and ...
Basic Outdoor Skills Must Be in your Mind
... keeps up the temperature of your body; gives your hint to the rescuers and cook your sustenance crude. For beginning the flame, pick the spot where dried woods are in copious quality. In the event that you don't have lighter or a matchbox, then beginning a flame may be troublesome for you. You can light a flame by utilizing your eyeglasses like an amplifying glass. A PDA battery likewise creates starts on making the short ...
Life on the ocean wave
... all chatting to fellow passengers so maybe that was the idea! Thankfully we had bodies that could manage a two hour stand. Given the demographic and fitness of a large majority others would have been severely impacted. Due to good planning and advice from the Trailfinders Cruise specialist we have a marvellous central balcony cabin which is very well appointed and by the sounds of it very spacious compared to some. The sun rises on our side of the ship and ...
Unexpected welcome encounters
Today I headed up to Warner Bros for the studio tour. It was interesting, saw the sets for Friends, Heart of Dixie, loads of films, Gilmore Girls and lots I can't remember. It's so interesting to see how they use the sets for loads of things but change minor details. Because of a lack of communication with Dave I ended up waiting on Sunset Boulevard for ages which sounds a lot more glamorous than it is. In the end I ...


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Need some inspiration? See a project you love? Click on an image to get more design details or add it to your shopping bag! Click here to see the latest and greatest ...How To Wiki is a place to learn and share knowledge. How to guides, hacks and other useful information. Add your guide today!I recently got a Roku box, and while there is an impressive list of available channels, I wanted to create my own. I searched around for a way to do this on the net ...6/30/2009 · How to download Files What Downloading Means. When you download a file, you access digital information (electronic "bits") from a remote computer using a ...Instructables is a place that lets you explore, document, and share your DIY creations.When I bought something at a store recently, the clerk handed me my purchase in a bag made from a newspaper. I liked it very much and had to make some more ...Food How To Marinate And Make Better Food. Throw a bunch of things in a plastic bag, put in raw meat, go to work (or sleep), and when you come back, best friends.Based on the previous blog post – steb-by-step guide to install Elysium, this tutorial shows how to create Metro style window on WPF XAML using Elysium.4/17/2013 · Despite the fact that you can find a cup of coffee on every street corner -- whether from a specialty coffee shop or a convenience store -- it's amazingly ...In this tutorial I'll show how to make a simple name generator. A sort of "build your own name generator" to experiment with. You just need to add your own word ...
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hmm why cant I edit the poll I made that... any ways it should be skilled based, a 4 star general is just as durable as a recruit
If it's not broken, you are not innovating.
Originally posted by CalmOceans
I'll be the drunk air hostess who spills drinks over everyone.
Can I take my shirt off in the back?
"We need men who can dream of things that never were." - John F. Kennedy
And for MMORPGs ever so true...
Flight Sims can be very complicated. Many of them require you to read the manual and actually learn a bit about aeronautics. Most modern mmorpg players are not willing to do that.
Maybe if you greatly simplify it so it plays more like an action style flight game then it would have a chance.
There are certain queer times and occasions in this strange mixed affair we call life when a man takes this whole universe for a vast practical joke, though the wit thereof he but dimly discerns, and more than suspects that the joke is at nobody's expense but his own.
-- Herman Melville
There you go -- supposedly arcade or realistic flight styles will be available and pitched against each other. Looks good...
Originally posted by h0dg1k1ll3r
I dont know how many of you are old enough to remember it, but the only really great, popular, and (mostly) realistic flight sim I've played was Strike Commander (1993, Origin Systems). You played a mercenary, and your gun ammo was unlimited, so that became your primary weapon. The aircraft health system was quite similar to that on War Thunder, you received some money for each target destroyed, and you had to take off manually using the basics, flap, airbrake, wheelbrake, etc. Everytime you lost a plane, it cost big bucks-lose 10 in the game and your base gets shut down. Getting an air kill was relatively difficullt, and it was easier to shoot someone down w/guns than w/missiles. All guided weapons were VERY expensive (100,000 for a guided bomb, 60,000 for a missile which only locked onto the rear of a plane), and whatever actually fit on the same plane in real life is what fit on yours.
. . . . .i dont know about popular but there are a ton of realistic simulators out there several of which i own and enjoy. never heard of this one though but meh i only got into them in the last 3 years so not suprised, but unlimited anything is a turn off for me in sim games like this. ether way ill have to look into it and check it out
F2P may be the way of the future, but ya know they dont make them like they used to
Proper Grammer & spelling are extra, corrections will be LOL at.


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Chef roble
Pozrite si súvisiace témy
Chef Roble Ali's Snapper with Tomatoes, Olives and Capers: Perfectly seared and peppery, this snapper recipe is perfect for long summer nights.
Chef Roble and Co Season 1 - Shrimp and Grits Appetizers perfect for my "La Crema" Style summer soiree....
Chef Roble Making Father's Day Chili
Chef Roble Ali, chef to the stars, shared his recipe for Whole Roasted Chicken that was so good, it even appeared on an episode of "Empire."
Mini Jamaican beef patties with scotch bonnet cream and micro cilantro. #FoodPorn (From Chef Roble)
Chef Roble's Cucumber Lemonade Granita. (shaved ice)
Chef Roble and Co Season 2 - Photo Gallery - Bravo TV Official Site
Chef Roble's Whole Roasted Chicken recipe is so good it was even featured on an episode of "Empire!" He joined Dr Oz to reveal how you can make it yourself at home.
Chef Roble
Chef Roble and Kikuyu - Peach Cobbler Push-Up with Crème Anglaise, Streusel


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The WAYWT Discussion Thread - Page 4206post #63076 of 1176663/2/12 at 8:41amsend them to blue owl.post #63077 of 1176663/2/12 at 10:08amwould still look better without the tuckpost #63078 of 1176663/2/12 at 10:55am
Would if I could, but the look of an untucked shirt would be less than agreeable in my office... normally I just wear a casual long sleeve button down if I'm going to the office in denim, but decided on a polo todaypost #63079 of 1176663/2/12 at 11:00am
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post #63080 of 1176663/2/12 at 11:07amQuote:
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If the dress code calls for no untucked shirts, then don't wear jeans. It almost never looks good.post #63081 of 1176663/2/12 at 11:29am
It is shameful how bad people must dress to conform to work dress codes.post #63082 of 1176663/2/12 at 11:36ampost #63083 of 1176663/2/12 at 11:40amfuck dress codes. whole world would be better without them. i want a gothninja accountantpost #63084 of 1176663/2/12 at 11:40ampost #63085 of 1176663/2/12 at 11:50am
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Quote:Originally Posted by furoQuote:
Nah, I just wasn't standing up straight. Here's another:Quote:
If you are implicitly required to tuck your shirt in, just don't wear a polo. It makes you look like a bestbuy employee.post #63086 of 1176663/2/12 at 11:56amI don't see how a tucked in polo is any more professional ... you're still wearing a white polo and blue jeans.
Also I just realized that was grizzlybear not ronnel. lolpost #63087 of 1176663/2/12 at 12:02pmpost #63088 of 1176663/2/12 at 12:06pmpost #63089 of 1176663/2/12 at 12:29pm
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Oh I can't stand this anymore..yesterday, the cardigan was on trial with the clueless riffraff as jury...today it's the polo...
First things first--the jeans--with that cuff folding they look ridiculous, especially with those dressy shoes...ignore the hipsters, it looks bloody daft. The belt is also too much with those jeans...
Now--the polo: The polo shirt is one of the classics of the 20th century that will last long after the last drop of petroleum is exhausted from the ground. The reason for its enduring success--versatility. There are so many styles, cuts, shapes, sleeve lengths, lengths,blah blah blah....but even with such diversity the polo is unforgiving. The fit must be precise.
First rule of thumb...upper chest, shoulders fit...it has to fit very snugly here. Yours does, good. You have chosen a more modern athletic fit with shorter arms, it seems to work for you...although it is impossible to tell this without seeing you move around in it. The collar is also modern, which is fine, and you've chosen to leave the buttons closed, that's also fine. You are doing a lot of things right.
Here is Sean Connery in Dr No, wearing one of the great icons of the 20th century--John's Smedley's Isis, available at Mr Porter, John Smedley online and all other fine, no lifetime return with no questions asked, non-riffraff establishments.
See how he has left the buttons opened, but also tucked in...but because of the simplicity of the pants and the lightness of the fabrics for the tropical Caribbean setting, it works!
Here is Fred Perry, also tucked in...but notice the casual belt and the non-domineering pants....
For yours, with that athletic fit with the rolling collar and the shorter sleeves, I also think untucked would work better...but tucked doesn't look bad at all actually.
If you want untucked, here is Daniel Craig in Tom Ford's plagiarism of another John Smedley 50-year-old classic--the Jeremy, also available at Mr Porter.
So for you, I would just lose the overaccessorizing and just loosen up...and ignore all the criticisms about polos...you look quite good actually.post #63090 of 1176663/2/12 at 12:34pm
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Advice from the master!Return HomeBack to Forum: Streetwear and Denim
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Cancer Cuts
Oncologists seek patients' budget help.
From the July, 2013 issue
Oncologists squeezed by the federal "sequester" are looking for help--from their patients. St. Joe's docs sent out what one calls a "Dear Patient" letter emphasizing that while they will still treat everyone "regardless of insurance," federal Medicare cuts make it harder to provide "high quality services."
Philip Stella, St. Joe's director of oncology, explains that with some drugs costing $5,000 to $10,000 a month, the sequester's 2 percent cut hits hard. If funding isn't restored, he says, St. Joe's docs--who operate as a private practice--may be forced to reduce staff and support programs. The feds pay nothing, he points out, for "four nurses in our employment doing nothing but taking care of patients on the phone."
As staff physicians, U-M Hospital oncologists are reimbursed differently, and are less worried. "There's lots of hype right now," says Hematology/Oncology chief Kathy Cooney. "The ultimate impact is not predictable." Still, U-M oncologist Sam Silver, like Stella, has protested the cuts to legislators and officials, both on the phone and face-to-face in D.C. And Stella says the stress for private practices is real. "They're unfairly targeting cancer patients," says Stella. "Doctors have to step up and speak for the patients."
[Originally published in July, 2013.]
Government, business, environment, the U-M, and more.>> Blogs
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The city wants downtown parking to generate an extra $3.7 million a year.
Plans to repeal Obamacare threaten the U-M Health System. But the hospitals have a hidden lifeline.
Exit Interview
As she departs for California, Sabra Briere considers the state of our town.
Software Blues
What happened to the city's NuView software?
Dill's Moment
It took nearly two years, but the county finally has a new administrator.
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September 13th, 2016
Episode 558 of 601 episodes
Every day is a gift from God! Learn how to live your life "on purpose," take control of your day, and use godly wisdom to manage your time.
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Welcome to the daily audio workout for your head.


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Title IX
Prohibited conduct
- Sexual exploitation
- Partner or relationship violence (including stalking)
- Sex or gender-based discrimination (including harassment)
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See definitions and more information on prohibited conduct.
Virginia Commonwealth University is committed to providing an environment free from sexual misconduct, assault, harassment or any sex/gender discrimination that may violate Title IX of the Education Amendments of 1972 and other state and federal laws.
VCU will take prompt and appropriate action to eliminate prohibited conduct, prevent its recurrence and remedy its effects. VCU will also offer reasonable and appropriate measures to protect a complainant and facilitate the complainant's continued access to university employment or education programs and activities. Such measures may include no-contact directives, residence modifications, academic modifications and counseling.
All reports of prohibited conduct will be addressed and resolved. Investigations of prohibited conduct will be conducted by civil rights investigators in Equity and Access Services. Those who violate the policy will face disciplinary action up to and including termination or expulsion.
All VCU employees are defined by the policy as either confidential employees or responsible employees. All responsible employees have a responsibility to immediately report incidents of prohibited conduct involving sexual assault, sexual exploitation and partner or relationship violence to the Title IX Coordinator.
Supervisors, management and human resources professionals are required to report incidents regarding sex or gender-based discrimination to the university's Title IX Coordinator. Reporting is required when such supervisors, management and human resource professionals know (by reason of a direct or indirect disclosure) or reasonably should know, of such incidents or conduct. For academic faculty, supervisors include department chairs, deans and other unit administrators.
VCU policy
VCU's policy on Sexual Misconduct/Violence and Sex/Gender Discrimination applies to the entire university community and third parties. The policy provides a fair and impartial process for all parties.
The policy replaces and supersedes the Title IX Student Sexual Harassment and Sexual Misconduct Anti-Discrimination Policy (Student Sexual Misconduct Policy) and the Prohibition Against Sexual Harassment. The policy applies to all prohibited conduct reported on or after Aug. 5, 2015. The procedures established under this policy will be used to address, investigate and resolve all reports made on or after Aug. 5, 2015, regardless of when the underlying conduct occurred. When the prohibited conduct occurred prior to Aug. 5, 2015, the former definitions of misconduct will be used.
See more information about the new policy.


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Call us, email us, tweet us, and let's get started.
918-493-5700 | firstname.lastname@example.com | @mandy_vavrinak
Rather than an exhaustive list, we think of it in pretty straightforward terms. We help our clients achieve their business goals.
Often a variety of tactics go into that, but where we start isn't with the "What" it's with the "Why." We get to know our clients, their businesses, their markets and marketplaces, their challenges and opportunities, their products and their people.
Then, we form proactive partnerships with them to become either an adjunct marketing department or their complete marketing solution. They expect excellence.
The formal answer is that at Comm-Arts, we create and execute Integrated Marketing Plans that achieve results which keep our clients coming back, year after year.
The slightly less formal, but possible more informative answer, is that we are a full-service creative marketing, design, and public relations firm. That means we can work with you to develop strategy, define needs, determine tactics, and execute the work required to reach your goals.
Yes, we "do social media." Yes, we "design brochures." But more importantly, we most often do both (or do neither, but rather do other things) for the same client because the strategy demands it, not because that's a thing we sell.
If you are ready to approach your marketing in a more integrated, strategic way, we can help.
And, because it sometimes helps to have a bulleted list… here are some of the things we do:


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Taking a little time to indulge, Bar Refaeli headed to the Epicurea Food Festival at the Bulgari Hotel in Milan on Tuesday (December 3).
The Sports Illustrated Swimsuit cover girl looked gorgeous as always in a black blouse and black pants with her blonde locks worn down over her shoulders.
She makes millions of dollars flaunting her flawless figure in front of the camera, but Bar Refaeli isn't above babysitting for a friend when the need arises.
The Israeli-born supermodel posted a photo to her Instagram account on Tuesday (November 26) to show her fans she's good with kiddos.
She's practically perfect as far as millions of men are concerned, but Bar Refaeli had to have mole removal surgery earlier this week to get rid of a pesky mark on her side.
The 28-year-old Israeli supermodel posted a pre-surgery photo to her Instagram account on Tuesday (November 12), and despite the hospital trappings she looked positively gorgeous.
Looking gorgeous while out and about in the Big Apple, Bar Refaeli strolled in Soho on Friday (October 18).
The Sports Illustrated Swimsuit Edition covergirl wore a green jacket over her green top and white skinnies as she chatted on her phone outside.
She loves sharing selfies, and Bar Refaeli uploaded yet another steamy pic to her Instagram account on Sunday (October 6).
The Israeli supermodel posed in a tiny two-piece bikini while basking in the sun, adding the caption, "Israeli water + Jordanian mountains = perfect weekend."
Looking to beat the midweek slump with an exciting evening out, Ashlee Simpson and Bar Refaeli both hit up Hooray Henry's nightclub in Hollywood last night (September 11)
Racking up the frequent flier miles, Bar Refaeli landed at LAX Airport in Los Angeles on Saturday evening (September 7).
The Israeli fashion model was stylish yet casual in grey sweats and a blue tank top with a large 31 on it as she rolled her own luggage through the terminal.
She's the hottest export to come out of the Middle East in decades, and Bar Refaeli is ready to head back home to Israel for a whole new "X Factor."
The stunning supermodel stars in a new promotional clip for her forthcoming show "The X Factor Israel," along with well-known talent guru Simon Cowell.


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Originally Posted by cross777
dude im not arguing with u ok but it a valid point cuz it does happen all the time weather it makes sense or not its a fact of life
Honestly though, I wouldn't say it happens like that way IRL, it sounds more like you've been watching too many military movies... Like drgnx has said many times, you do not want to put troublemakers where they can cause more trouble, and even if they are troublemakers but get promoted anyway, it means they got other qualities that still make them fit for the job.
Avatar and signature by me.
Forum Rules


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4 stars
Festival Music Society, Indiana History Center; June 26
The second of the six FMS-sponsored summer Early Music Festival programs featured only two composers: George Frideric Handel and Alessandro Scarlatti - more than sufficient to give us a sustained evening of high-quality Baroque music, both played and sung. Especially when presented by a Philadelphia group called Tempesta di Mare ("Storm at Sea," named from a Vivaldi concerto), which impressed more than the Rebel group of two days earlier with their precision and balance.
Archlutist Richard Stone and recorder player Gwyn Roberts directed the ensemble's remainder: violinists Karina Fox and Emlyn Ngai, cellist Eve Miller and Baroque soprano Clara Rottsolk. From Scarlatti (whose son, Domenico Scarlatti, became yet more famous as a harpsichord-sonata composer forming a unique bridge between the Baroque and Classical eras), we heard two chamber cantatas, perhaps the two evening highlights: "Bella, s'io t'amo il sai," with Rottsolk joined by Stone, Roberts and Miller, plus "Bella dama di nome Santa," featuring all six performers.
Rottsolk showed beautiful control with a pitch-perfect "white" voice occasionally embellished with vibrato at a phrase ending. It appeared that Stone used an archlute, long-necked but with a smaller body than the theorbo, more often seen in these series. Handel was represented by a concerto, a trio sonata and a chamber cantata of his own. Roberts offered dazzling recorder work, especially on her small, high-pitched instrument. On second thought, the entire evening presented nothing but highlights.


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Michelle Grattan reports from Canberra each weekday on Breakfast. Counterpoint and Late Night Live dip into all sides of political commentary and, if it's serious news, it'll be discussed all over RN from RN Drive to Sunday Extra.
October 22nd, 2015
Episode 1108 of 1761 episodes
We've heard a lot about Peta Credlin, Tony Abbott's former right-hand woman. But what precisely is the role of the chief of staff to the Prime Minister?
You'll need to sign in to write a comment.
Welcome to the daily audio workout for your head.


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|Message view
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|Saberex <Sabe...@gmx.net>
|How to switch off transitive maven2 dependencies while building with ivy2
|Wed, 03 Jun 2009 06:36:10 GMT
Hi to all, I ´am thinking about how ivy2 is resolving dependencies. The build of my artefacts is ported from IVY 1.4 to IVY 2. Since that time some of the developers started a new project build with mvn2. My problem now is that the jars in the mvn2 build are newer and higher versioned than the ivy2 jars. I need the resulting mvn2 artefacts for the ivy2 build but not the other in the mvn2 pom declared dependencies. I know how to get ivy2 to download the needed artefact from my maven repo but it downloads all dependencies and put then on the classpath and the tests at the end are failing. Thanks for your help Saberex -- View this message in context: http://www.nabble.com/How-to-switch-off-transitive-maven2-dependencies-while-building-with-ivy2-tp23846160p23846160.html Sent from the ivy-user mailing list archive at Nabble.com.
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XenServer 5: More Management, More HA
Citrix has released version 5 of its virtualization solution, XenServer, claiming to have made more than 100 improvements to the product.
The commercial software is based on the open source hypervisor Xen in Linux kernel, and supports both Intels virtualizations technology VT, and AMD-V.
Citrix presented the new Xen version as part of its product-line Citrix Delivery Center, which will integrate its virtualization products from server platform to desktop computer, and deliver a more dynamic PC performance. Also in the portfolio is Citrix Cloud Center (C3), which is aimed at the providers of cloud computing services.
The management tools of XenServer 5 are meant to give administrators an improved overview of the system territory, it allows the labeling of workloads and virtual machines similar to Web 2.0 tags, to help sort and search for costs, locations and performance criteria. Citrix promises the new installation of Xen should take no more than 10 minutes.
On the high availability features of the new version, Citrix worked together with Marathon Technologies. This means Citric customers that buy the XenServer 5 Enterprise or Platinum edition will also have auto restart abilities. Higher HA levels via Marathon's Everrun VM are also available at a surcharge.
The recommended price for the XenServer 5 is US$ 900 per server, Xen management software and a one year subscription to Citrix Advantage included. Along with the 30-day restricted evaluation version, a free Express Edition of the software is now ready for download, limited to one server but not in the view of VM's or memory support.
Issue 28: GIMP Handbook 4th Ed./Special Editions
Buy this issue as a PDF
Munich Plans to Ditch Linux and Go Back to Windows
A major setback for the Linux desktop.
Linux Kernel 4.10 Comes with New Security Features
Improved support for GPU in virtualization.
OpenSUSE Site Hacked
News site for the openSUSE community falls victim to a Wordpress exploit.
LibreOffice Goes Online with 5.3 Release
The source code is available online.
Microsoft Brings Clear Linux OS to Azure
One out of three virtual machines on Microsoft Azure Cloud run Linux.
ASUS Announces a Single-Board Computer
The form factor of the board makes it a drop-in replacement for Raspberry Pi.
Red Hat Releases RHEL 6.9 Beta
Makes it easier for customers to move workloads into container-centric applications.
SUSE Working on a New Operating System Called MicroOS
SUSE's answer to container-centric operating systems.
Biggest Kernel Release Ever
Linux 4.9 is the biggest release in terms of number of commits.
CentOS Linux 7 (1611) Released
The latest version of the official RHEL clone is here.


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Tag: Car-Free - Page 11
San Francisco Turns Intersection into Park in 72 Hours (Video)
Image credit: StreetFilms Dangerous intersection reclaimed as public space One of my favorite things about the folks at StreetFilms is that they don't just report on innovative projects for livable streets - they deconstruct what has been done so we can
Global Car Survey Finds Six In Ten Say Green Is The New Dream
Global market research firm Synovate has released a study showing that six in ten people "would choose to buy a green car over a dream car, even if money was no object."
eCycleway - Safe Urban Cycling or Dangerous Segregation?
It is an undisputed truth that the majority of American cities have incomplete bicycling infrastructures. This is perhaps especially true in Los Angeles, where
Haven't Biked Yet? Don't Berate Yourself. Read Bicycle Lifestyle Guide
This new 30-page booklet, Bicycle Lifestyle Guide, takes just an hour to read, and it is an inspiring and cheerful general audience guide to urban biking from the non-profit C.I.C.L.E. organization. If you thought bike
Solar-Powered Bicycle Parking Pods Provide Solar Hot Water Showers in Queensland
It's a shame we missed this for the recent Ride To Work week. Because it directly answers the main concerns people have about commuting on bicycles, namely arriving at work sweaty from exercise or wet from rainy weather. Business partners Tim Ceolin
Lorax Motor's 900 mpg Hauler, It's A Solar Tricycle
Our pals over at the excellent Wend Magazine thought our readers might be intrigued by a new company they found. I reckon they're right. For they've unearthed the delightfully named Lorax Motor Works, a start-up who are providing purpose built
7 Things I Wish Every City Would Do to Make Urban Living Even Greener
Though it sometimes might not seem so, living in cities is a pretty green thing to do. Two prime reasons being that average home sizes are smaller and transportation distances are generally shorter, both leading to lower
Recycled Bike Guards Stop Rider From Getting Trashed
Two guys, who used to work for Planet Bike, whom we profiled recently, have since set up Portland Design Works (PDW). Their mission:
20 Freaky Bikes As Selected by Matador Life
Matador Life is about people in their hometowns, how they represent where they're from, and what we can learn from each of the unique places we inhabit. Amongst the portraits of people's hometowns and profiles of individuals strongly rooted in their
Bike to Work, Pocket 20 Bucks a Month
Remember that Renewable Energy Tax legislation that passed a few months ago? It was filled with all sorts of green goodies, like alternative energy credits and money for weatherization assistance programs. Congress,
One Wheel Wonder: ExtraWheel's Voyager Bike Trailer
It's not often that TreeHugger visits Poland, so we are pleased to present ExtraWheel, who hail from Nowy Targ in the south of the country. They produce an incredibly simple, single wheel bike trailer, that doubles as an emergency spare
Folding Bike Recall for Dahon and REI
Any regular reader of TreeHugger knows we are passionate advocates for bicycles, and that we also have certain penchant for folding bikes, due to their extra versatility. So it was with a heavy heart that we noticed that U.S. Consumer Product Safety
Gruber Assist is a Stealth Electric Bike: No One Will Know But Your Mechanic
In honor of bike to work week, here's a product to help the hill-plagued bicycle commuter - Gruber Assist, a 200 watt electric-assist motor which hides in a bike's seat stem. I am
Ten Reasons Not to Bike To Work. All Debunked. Threefold
The mayor of Copenhagen reckons Biking to Work in that city is as commonplace as brushing one's teeth. But, as was evidenced by Utah's plan to make cycling fashionable, much of the rest of the western world is well served by awareness-raising
Modular, Sporty, Flexible Steintrikes from Bike Revolution
Image: author Steintrike Mungo Takes the Stairs Apologies for the unfocused photo, but when a Mungo flashes past you down the steps, there is not much time to point and shoot. The amazing suspension in the Mungo Sport trike makes going anywhere easy.
Haul A Heffalump with Help From Bikes At Work
OK, so you were slowly coming around to the idea of ditching your car and taking up cycling. For the workday commute, the weekend recreation and the after hours trips to do the shopping. But then you thought, "Hold on a minute, how do I get the
The IF Mode: Full Size Bike Folds Flat Fast
The much mooted IF Mode, a 26 inch folding bicycle, is almost available stateside. Finally. The bike has sprung from the fertile imagination of Mark Sanders, of MAS Design, who is also behind the Strida and X Bike.
Bike Bonus: In One German Town, You Can Cash in On Car AND Bike Swaps
Germany's 2,500 Euro car swap rebate, which came into effect back in January, has been controversial - organizations such as the Association for Sustainable Mobility say it


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Articles About environmental sustainability
Local food activists strategize, plan for a commercial kitchen
A growing interest among villagers around local food has led to an ambitious effort to make the village a regional food hub, with an initial step of creating a commercial kitchen as the first component of a community economic incubator.
Plan, curtail for climate goals
Villagers Faith Morgan and Pat Murphy believe planning a personal energy budget and curtailing personal energy use are the essential actions individuals can take to help slow global warming.
The Rumpke Landfill and Recycling Center: a YS News pictorial
An article published in this week's paper discusses a recent tour of the Rumpke landfill and recycling center organized by Vickie Hennessy and Zero Waste Yellow Springs. Words cannot do the facilities justice.
Seeding a food revolution
Here in the heart of industrial agriculture, a quiet revolution has begun. It's small-scale, and plans to stay that way. Its dimensions are measured not in acres, but millimeters.
Yellow Springs Resilience Network ramps up efforts
Yellow Springs Resilience Network hopes to insulate the village from the worst impacts of climate change.
Antioch College is a real food leader
According to Antioch Food Service Coordinator Isaac Delamatre, 56 percent of Antioch's food is considered "real", meaning sourced from locally owned, ecologically sound, humane farms with fair employment practices.
Village Council denies appeal to stop solar array
At its July 21 meeting, Village Council voted unanimously to deny an appeal of Planning Commission's June 23 decision to allow a solar array at Antioch College. The decision means that the college solar project is allowed to go forward.
Help spread pancake cheer at the Glen
The Glen needs volunteers to put on its once again annual Pancake Breakfast friend-raiser next weekend.
Antioch College Farm raises animals, concerns
The farming activity on what is affectionately known as the Antioch golf course is just beginning, and it's the heart of what Antioch College envisions for its sustainability program, one of the key components of the college curriculum.
Antioch College, Glen Helen begin reforestation
If one of the key components of an effective education is giving people the tools to make positive change, then Antioch College, Glen Helen and the host of conscientious villagers here are in a strong position to help save the environment.


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Hug your finger with this nocturnal creature! Crafted in 18K yellow vermeil over sterling silver, this owl ring showcases two round cut 3mm Madeira citrines in bezel settings and 13 round cut 1.3mm white zircons in prong settings.
Click here to find your ring size.
From the NYC II® Collection. Gemstones will vary in color or patterns. Please allow for these natural variations. All weights pertaining to diamond weights are minimum weights. Additionally, please note that many gemstones are treated to enhance their beauty. Click here for important information about gemstone enhancements and special care requirements.
Vermeil Plating:
Pronounced "vermay," vermeil is an electroplating process in which 14K gold or higher is coated over sterling silver. Officially designated by the jewelry industry, items may only be sold as vermeil if they have a minimum thickness of 100 millionths of an inch (2.5 microns) of gold over the silver. Regular gold plating is less than 2.5 microns.
The "vermeil" technique of plating sterling silver with gold originated in France in the 1750s. It differs from "gold filled" or "gold plated" in terms of the thickness or thinness of the microns over sterling silver. "Gold filled" pieces have a much thicker layer, between 15 and 45 microns, which is mechanically bonded to the base metal with heat and pressure. Vermeil is a more expensive version of "gold plated". It does not wear off as quickly as gold plating does. However, over time, vermeil wears off and therefore will require re-plating.
Gold/Platinum Embraced Silver or Bronze:
Our platinum and gold embraced collections feature layers of platinum or gold over sterling silver or bronze for a lustrous, radiant finish everywhere you look and touch.
To care for your plated jewelry items:
Named from the French word for lemon, "citron," citrine is a variety of quartz available in a range of golden hues from lemon, to straw, to sun yellow, to deep gold, to orange, brown and deep red. Darker colors are more highly valued, including the medium golden-orange and dark-sherry colors, sometimes called Madeira citrine after the color of the wine.
Citrine crystals can form together with amethyst to form ametrine, or with smoky quartz to form bicolored quartz. Citrine is generally less expensive than amethyst, and is also available in a wide range of calibrated sizes and shapes, including very large sizes. Considered an alternative to topaz as the birthstone for November, it is also thought to be the traditional gift for couples celebrating their 13 th and 17 th wedding anniversaries. Citrine ranks a 7.0 on the Mohs Scale, and because of this durability, it is ideal for jewelry wear.
Citrine is found in volcanic rocks and quartz veins and owes its color to the presence of iron. Most citrine is mined in Brazil, but almost all of the Brazilian material is heat-treated amethyst. Supplies are most plentiful in the Brazilian state of Rio Grande do Sul, particularly from the Serra Mine. The Ira' Mine also produces large quantities of the gem. Citrine can also be found in the Ural Mountains of Russia, in Dauphine, France, and in Madagascar.
In ancient times, citrine was carried as a protection against snake venom and evil thoughts. It was thought to give calmness and mental balance to its wearer. Throughout history, people have confused citrine for topaz. Many citrines were sold as topaz and thus thought to carry the same qualities, such as knowledge and beauty. Today, citrine symbolizes truth and integrity, and is believed to promote creativity and personal clarity. It is also believed to impart happiness and cheer to its wearer while raising self esteem, as well as cleanse, regenerate and attract abundance.
Zircon often suffers for its name's similarity to "cubic zirconia," the simulated diamond. The stone zircon, however, is actually a beautiful natural gemstone. It is named from the Persian word "zargun," meaning "gold-colored." This is despite the fact that it comes in a wide range of rainbow colors . The majority of zircons are brown or yellow-brown, while pure red and green are the most valuable colors. The yellow-red to reddish-brown variety is called "hyacinth."
For many years, the most popular type of zircon was the colorless variety. More than any other natural stone, colorless zircons produce a brilliant sparkle similar to diamonds . The most popular color today tends to be the bright pastel blue variety. Sometimes called "starlite," blue zircon has recently become considered an alternative birthstone for December.
Zircon is one of the heaviest gemstones, meaning that it will look smaller than other varieties of the same weight. It ranks a hardness between 6.5-7.5 on the Mohs Scale and is mined in Cambodia, Sri Lanka, Thailand, Myanmar and Australia.
Travelers during the 11th century wore zircon amulets for protection and to encourage welcome greetings on their journeys. In the Middle Ages, the stone was said to bring wisdom and prosperity to its owner. Hindu mythology even mentions the gem when referencing the Kalpa Tree, which was a glowing tree covered with gemstone fruit and leaves of zircon.


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My Tyler End Table is a stylish and functional way to accessorize your living space. With a removable top, this end table provides handy hidden storage!
Includes one table only.
Product Details:
- Dark Brown finish
- Black poplar, plywood, oak and vinyl construction with MDF surface top.
- Wipe clean with a damp cloth.
Tyler End Table
Hidden Storage End Table
Shipping Info
Shipping Info
In stock items usually ship within 10 days via Bob's Delivery Service. Lamps, Rugs, Bed Pillows, Bed and Pillow Protectors, select Kids Chairs and select Mattresses ship via FedEx through my Bob's Value Express program when purchased alone or in combination with each other. If purchased along with furniture, Bob's Value Express items will ship via Bob's Delivery Service. Mattresses shipped via FedEx / Bob's Value Express require special set up. Click here for details. Bob's Gift Cards ship FREE via USPS Ground Shipping or via FedEx 2 Day Shipping for only $9.50. A Bob's representative will call within 24 hours of placing an order to schedule Bob's Delivery Service, arrange a Pick-Up date or give FedEx delivery information.
Please note:
**Due to limited quantities, most Outlet merchandise must be delivered within 2 weeks, pending available delivery dates. Some Outlet items may require transfer within distribution centers requiring up to 3 – 4 weeks for availability.
**Mattresses shipped via FedEx under the Bob's Value Express program do NOT qualify for removal of old mattress and foundation.
For more information about shipping and delivery charges, click here.
- What is Goof Proof Plus?
- Description
My Tyler End Table is a stylish and functional way to accessorize your living space. With a removable top, this end table provides handy hidden storage!
- Specs
Short Description Hidden Storage End Table SKU 20008064 Color Black & Brown Height 23 Width 22 Depth 22 Collection Tyler Material Wood/Vinyl Finish Dark Brown Style Transitional Warehouses Taftville, Shorewood, Aberdeen


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This beautiful collection of laptop cases brings a contemporary slant on classic design. Each case has been carefully crafted with a stylish approach to practicality. Constructed from quality materials, each case features a protective padded laptop section so you can be sure that your laptop is safe. Carrying is made comfortable with a cushioned shoulder pad. The length of the shoulder strap is adjustable and the strap can be removed completely if desired. The trolley strap on the back of the case allows you to securely attach the case to luggage for easy transportation. Keeping belongings organised is easy with the rear document section and a selection of sized pockets designed for convenience, which are easily accessible in front zip down section and in the main compartment.
Catalogue Number: 428-3966
- Adjustable shoulder strap
- Padded handle
- Trolley strap
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Buy on Tesco Direct from:
Available from Cleverboxes
Earn 30 Clubcard points
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4 more buying option(s) available.
Available from Buyur
Available from MoreFrom
Available from Laptop Outlet
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Product Details
Product specifications
Additional Information
Maximum Screen Size To Fit (in)
Key Information
Laptop bag
Compatible Device
Universal laptop bag


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Trump Today: Some news outlets blocked from White House...
At least 18 TV shows in danger of being cancelled
Photos show the insane amounts of snow piled up in Tahoe
See this amazing photo of the Oroville Dam from space
Warriors contact Turner Sports about JaVale McGee coverage
Karl Lagerfeld calls Meryl Streep 'cheap' for cancelling...
Time to rethink SF? These US cities have better tech salaries
Update: Andrew Bogut eligible to return to Warriors
Mission District's La Taqueria to close on Mondays
CPAC crowd waves tiny Trump-branded Russian flags before they...
Posts filtered on Category
Calling all Beauties!
By Sophie Shulman Stars Model Management is searching for Marin's next top model. If you are between the ages of 13 and 21 and at least 5'7″ for girls and 5'11" for boys, keep reading! The open call, …
Paul Simon, Jamie Redford and Hooman from Alice 97.3 at the Sausalito Film Festival May 11-13
By Sophie Shulman at Marin Magazine For those who love movies – especially documentaries − head to Sausalito for the 4th annual Sausalito Film Festival May 11-13. The festival brings a curated …
Registration for the annual Mother's Day BBQ ends tomorrow!
Still not sure what to do on Mother's Day? Tomorrow (May 5th) is the last day to register for the Mother's Day BBQ at the Martin Griffin Preserve in Stinson Beach on – you guessed it – Saturday, May …
Just in time for Cinco de Mayo! Sausalito's Copita hits the scene.
By Logan Elle Link, Marin Magazine There is officially a new Mexican spot hitting the Sausalito dining scene – and just in time for Cinco de Mayo. Executive editor Mimi Towle and I just got back from …
Dwell + Marin Magazine modern home tour this weekend
Ever wish you could take a peek inside some of Marin's most stunning and cutting-edge modern homes? Well, aren't you lucky … this weekend is the 2nd annual Dwell + Marin Magazine home tour. The …
Are you a sailor? Win $100 at Spinnaker Restaurant
America's Cup countdown How well do you know the history of the America's Cup? Be the first to answer the following questions correctly via our online poll, and you'll win a $100 gift certificate for …
Watching the Oscars in Marin?
Of course Meryl Streep is brilliant, we all know that…but when it comes to the Oscar, should it go to her for her role in Iron Lady or the hot new-comer Rooney Mara who played "the girl" with the …
Get front row seats for Saturday's San Rafael Boat Parade!
Here at Marin Magazine, we've made it pretty clear that we're loving the stand up paddleboarding craze. In fact, we have a thing for anything and everything water-related, which would explain why …
10-year-old Isabella Carlucci gets into the holidy spirit at ACT
Marinites know how to get into the holiday spirit, but sometimes it's the littlest ones that really bring on the cheer. Here at Marin Magazine, we were thrilled to hear about all of the Marin kids …
Spooky side trips
With Halloween just around the corner, Marin Magazine editorial intern David Pascoe found some spooky and spirited side trips. 1 Truckee History Tour This year's third annual historical walking tour …


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The objective of the proposed research is to discover, characterize, and validate small molecule natural product-derived hypoxia-inducible factor-1 (HIF-1) inhibitors as adjunct agents for cancer therapy. The long-term goal is to develop cancer chemotherapeutic agents that specifically target tumor hypoxia (low oxygen tension). Solid tumors contain hypoxic regions and the extent of hypoxia correlates with malignant progression, resistance to radiation treatment and chemotherapy, and relapse of the disease. Hypoxia-associated treatment resistance can be caused directly by reduced cellular oxygen concentrations or indirectly by hypoxia-induced modifications in gene expression. We propose a new approach that specifically targets this important indirect effect of hypoxia (alteration of tumor gene expression). There is no approved drug in clinical use that specifically targets hypoxia. This drug discovery program uniquely combines natural products chemistry with cutting edge biomedical research.
Specific Aim 1 will evaluate natural product-rich extracts, isolate and elucidate the chemical structures of active leads that inhibit hypoxia-induced and/or constitutively activated HIF-1, the principle transcription factor that activates the expression of adaptation and survival genes under hypoxia. Not only does HIF-1 promote hypoxic tumor survival and metastasis, oncogenic activation of HIF-1 is also associated with malignant progression and treatment resistance. Natural product-rich extracts will be examined in a panel of high-throughput bioassays for HIF-1 inhibitory activities (hypoxia-induced and oncogenically activated). Active compounds will be isolated through bioassay-guided isolation, and their structures elucidated using a combination of spectroscopic and spectrometric methods. Proof of principle has been established by the discovery of some of the most potent small molecule HIF-1 inhibitors.
Specific Aim 2 will determine the effects of active compounds on hypoxic tumor cell survival, angiogenesis, and metastasis. A panel of tumor cell lines that represent different disease stages and hypoxia responsiveness will be used as in vitro models. Nontoxic active compounds that inhibit hypoxic tumor cell survival, angiogenesis, and metastasis in vitro will be further investigated in genetically engineered murine breast cancer models.
Specific Aim 3 will investigate the therapeutic potential of natural product-derived HIF inhibitors as adjunct agents with chemotherapeutic agents. The goal is to identify the optimal combination of HIF-1 inhibitors with chemotherapy that can achieve the maximum efficacy of inhibiting tumor growth with low toxicity.
Specific Aim 4 will characterize natural product-derived HIF inhibitors at the molecular and cellular levels and resolve the mechanisms of action. Accomplishing these objectives will provide antitumor drug leads and molecular probes that will afford new insights into the intracellular pathways that mediate hypoxic signaling.
This project is highly relevant to public health because the goals are to discover and develop new drugs to treat breast, prostate, and other forms of cancer. The proposed research is aimed at the discovery of tumor-selective small molecules that will have markedly fewer side effects and less toxicity than most current chemotherapeutic agents. These compounds will target unique physiological differences in the tumor environment and specific genetic differences in tumor cells that allow them to survive and grow even under conditions where they are deprived of oxygen.
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