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The Watch Appreciation Thread (Reviews and Photos of Men's Timepieces by Rolex, Patek Philippe, Breitling, JLC etc...) - Page 674post #10096 of 483121/25/12 at 4:48amThere is one in the Burlington Arcade "The Vintage Watch Company" http://www.vintagewatchcompany.com/post #10097 of 483121/25/12 at 5:47am
Quote:Originally Posted by Cylon
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Quite a few people have already expounded on the direction I was heading, but I would definitely rather commit a quartz "mistake" with a Cartier Tank than that Hermes. I consider Cartier a jeweler first, and a watchmaker second but Dino944's Tank certainly made me challenge my preconceptions there.
The Cartier Tank is a pretty respected design in watch circles with endless tradition (it is actually inspired by Renault tanks from WWI), although the movement quality has varied over the years. Cartier decided to get real about it and start making an in-house movement which you can see in the Calibre de Cartier.Quote:
I may still pick up the RL watch, but I am waiting for a dealer to come down to a more sane price. I talked to one of the sales reps who said that the RL watches weren't selling all that well (no big surprise), so I feel like it is just a matter of time. Some of the other RL sporting watches are also actually quite handsome as well and have JLC movements in them.Quote:
I have a cordovan NATO strap on the way, so I will probably put it on and see how it goes.post #10098 of 483121/25/12 at 5:47am
What I've heard - avoid Burlington Arcade and talk to good dealers instead (Austin Kaye, David Duggan and Daniel Bourn).
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/Mpost #10099 of 483121/25/12 at 6:08amQuote:
Amen. In terms of style, its timeless. What tends to bug me about Cartier is the ubiquity of their quartz items dragging down their more refined pieces. They've made this calculation in deference to female clientele who prefer quartz to mechanical. From a business perspective, its probably the right decision however as a man it does affect my decision in purchasing one.
Edit: Actually, don't think its accurate to state women prefer quartz to mechanical, but rather women don't see much of a reason to pay a premium for a mechanical timepiece (though there are exceptions). At the end of the day, its one form of jewelery or another, so they could pour that difference into some pearls, sapphire earrings, diamond tennis bracelet, etc. We men, all we have is watches so we tend to be a bit more demanding.
Edited by Cylon - 1/25/12 at 6:24ampost #10100 of 483121/25/12 at 6:14am
And I must admit I kinda like that PP on a NATO strappost #10101 of 483121/25/12 at 6:22am
Quote:Originally Posted by culverwood
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There is one in the Burlington Arcade "The Vintage Watch Company" http://www.vintagewatchcompany.com/
seriously- the markup at this place is just laughable. a nice vintage oyster/air king here costs around 3 grand, when it could be had for around half that at austin kaye or £750 or so on tz.post #10102 of 483121/25/12 at 9:38am
post #10103 of 483121/25/12 at 11:35am
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post #10104 of 483121/25/12 at 11:45amQuote:Originally Posted by Cylon
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I am loving all the action in here of late...well most of it
1. From a Hermes watch to a gold Panerai with a radioactive green strap...YIKES.
Quite a few people have already expounded on the direction I was heading, but I would definitely rather commit a quartz "mistake" with a Cartier Tank than that Hermes. I consider Cartier a jeweler first, and a watchmaker second but Dino944's Tank certainly made me challenge my preconceptions there. Whatever you think about Cartier, that its more for ladies or the price you must pay for the Cartier name, his is a beautiful first-rate timepiece. I too cannot wait to see the 3rd VC you have in your pocket slowly killing us as we wait, because the two you have already presented us are very interesting, unique choices. They strike me as carefully selected, and are an absolute pleasure to look at. I look forward to reading your posts whether pics or info.
Hi Cylon,
Cartier is probably one of the most under rated and under appreciated watch companies in the world. They truly were at the forefront in moving from pocket watches to wrist watches. Some of it may have to do with their fame for making jewelry for royalty and celebrities. However, they have made lasting quality pieces often using the finest movements available, from EWC, Jaeger, JLC, Piaget, F. Piguet, THA, to name a few. Mention the Cartier Tortue Mono-Poussoir (Single Pusher Chronograph) and you will find it is a watch that is highly respected even among watch snobs that are usually only interested in Patek, AP, VC, and Lange. A few relatives of mine that own some really nice Pateks, Langes, and JLCs, were trying to located a Tortue single pusher chrono or Tank XL before production ended. Cartier has often used a multi tier approach to watches, something that Rolex did and maybe protected their brand name a little by selling their lesser line of ETA powered watches under the name Tudor. Cartier allowed people that did not want to spend huge money on a watch to still own a Cartier buy selling a Les Must line and also by using ETA movements in their more ordinary models. However, I think you will find that most of the more classic and higher end pieces, have used very high grade movements. In addition, almost any pre-1970 Cartier is in very high demand by collectors, and Cartier itself has a standing offer to buy them back from anyone that owns one. In addition, many of the recent CPCP pieces are quite coveted and owners often get unsolicited offers to buy.
I don't think they should have offered quartz movements in their Tank, or a lesser watch like a Tank Solo. However, I think our generation is quick to forget that in the 1970s and 1980s most great brands offered their watches with a quartz movement and it was uncertain in the 1980s if automatics and manual winds would still be around in a few years. Patek, AP, VC, IWC, Rolex, Piaget, etc were all making quartz models to meet the demand for the latest technology. There were Patek Calatravas, Nautilus, AP ROs, IWC Igeniur SLs, and Datejusts availble and regularly sold with quartz movements. It was only really in the late 1980s early 1990s that manual wind and automatics came back into favor. Can you imagine, that in the early 1980s vintage manual winds were so unpopular that people could easily buy a Patek, AP, or VC Perpetual Calendar Chronograph for about $2,000-3,000 USD (or back then the equivalent of a steel and gold Submariner)? Now those pieces are well into six figures.
As for women's watches, none of the major companies other than Rolex, offer a large number of automatic or manual wind watches for women. The ladies market at least for the last 20+ years is still strongly in favor of quartz watches. Maybe its that most women just aren't that interested in watches so its mostly jewelry for them. Check with most manufacturers and the bulk of offerings for ladies from AP, JLC, Patek, VC etc are quartz. Sure there are a few hand wound pieces but not many. Its a problem my wife often has issues with. She will only buy a manual or automatic watch so it limits her choices.
Cartier may not appeal to everyone but hopefully seeing a few interesting pieces will open peoples minds to the fantastic pieces they've made that may have been overslooked in the past. I have a relatively rare steel and platinum Cartier Pasha Chronograph that I will try to post some photos of soon. Maybe I should save the VC posting for over the weekend or beginning of next week.
Best regards,
Quote:Originally Posted by akatsuki
The Cartier Tank is a pretty respected design in watch circles with endless tradition (it is actually inspired by Renault tanks from WWI), although the movement quality has varied over the years. Cartier decided to get real about it and start making an in-house movement which you can see in the Calibre de Cartier.
Hi Akatsuki,
While Cartier has offered some quartz versions of the Tank, the classic manual wind Tank and its variations (Tank Cintree, Tank Obus, Tank Chinoise) have always used very high grade movements from very respected makers. They are making a lot of their own movements for higher end pieces. But we should also be mindful that even brands like Patek, AP, and VC have not exclusively made all of their own movements. They have used movements from Lemania, JLC, and F. Piguet. Patek only recently stopped using outsourced movements in their chronographs (their 5070 and 5970 both used a Lemania base also used in some VC chronographs).
Best regards,
Anyone want to guess what brand supplied the same base movement to Patek, AP, and VC, and never used that same movement in their own product?post #10105 of 483121/25/12 at 11:48ampost #10106 of 483121/25/12 at 11:48amThread Starter
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post #10107 of 483121/25/12 at 11:53amQuote:Originally Posted by atila
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Good tips, thanks...
I've found out that the models that seem to appeal to me more are the older, 80s model face with the Sigma style markers - not a fan of the roman numerals/numbers. I only see the sigma style "dash" markers on models from the 70s and 80s, do they make them on the newer models as well?
I have become more undecided on the jubilee/oyster, I am definitely waiting it out as I am in no rush and being this is my first Rolex, and I'm still just 24, I want it to be right.
edit: Love this type of face, just with a blue dial:
If choosing a Datejust thats from the 70's or 80s you should have a lot to choose from. However, a Jubilee bracelet that is that old will probably resemble a bunch of paper clips strung together unless it was rarely worn. Even some Oysterbracelets from that vintage can be a rather tired. Only other thing to consider is Datejusts that are that old will also have an acrylic crystal rather than a scratch resistant synthetic saphire crystal (you have to be into the 1990s to get a saphire crystal). Not a big deal, just something to consider.
post #10108 of 483121/25/12 at 11:56am
Quote:Originally Posted by gyalos
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There is a shop in London that does that thing with rolexes and birth years. And while at it, does anyone have or care to share any experiences with any one of these second hand shops that are scattered across the Mayfair area? The stated prices seem rather high, are they negotiable?
In my opinion most of those shops are overpriced and have huge mark ups, mostly catering to tourist trade.
They are especially bad for trade ins/valuations.
Check chrono24.com, there are many reputable UK dealers on there, blowers is one of the best.post #10109 of 483121/25/12 at 12:03pmQuote:Quote:
For a quirky twist to a somewhat funky watch I actually like the green/gold combo.... there I go throwing my elegant, simple, classic aesthetic out the window, but I dig it!post #10110 of 483121/25/12 at 12:04pmReturn HomeBack to Forum: Classic Menswear
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This is a revised new Program Project application from an interactive group of experienced investigators consisting of 3 projects and 3 cores. The overall theme of this PPG is to understand how arterioles are regulated by interactions between cell integrins and extracellular matrix (ECM) proteins and how these interactions are disturbed by vascular disease. Over the last 12 years, program investigators published most of the early work establishing a key role for integrins in microvascular control. Recent insights by our investigative team have identified key integrins and ECM proteins setting the stage for major breakthroughs in this field that will significantly advance our understanding of this paradigm for microvascular control. A central premise of this PPG is that microvascular control in health and disease is influenced by properties of the ECM and ECM interactions with integrins on cells of the microvascular wall. Project 1 will examine the ability of vasoactive mediators to influence integrin-ECM adhesion and determine how adhesion is coordinated with microvascular smooth muscle cell (mVSMC) contraction and control of arteriole diameter. Project 2 will examine the ability of ECM proteins to signal through integrins and modulate Mvsmc membrane conductance of Ca2+ and K+ to control vasomotor tone. Project 3 examines a unique hypothesis that during inflammation emigrating leukocytes cause ECM degradation that generates integrin-binding signals that impair control of arterioles. Core A will provide administrative support for the PPG. For all projects, Cores B will provide imaging technology/support and Core C will provide for molecular and cell level technologies. Together, the projects will shape an integrated view of microvascular regulation using model systems that include freshly isolated mVSMC, isolated arterioles and microvascular network preparations. A multidisciplinary array of technical approaches ranging from atomic force microscopy, fluorescence microscopy, electrophysiology and molecular techniques will allow a comprehensive and systematic exploration of concepts.
|Sehgel, Nancy L; Sun, Zhe; Hong, Zhongkui et al. (2015) Augmented vascular smooth muscle cell stiffness and adhesion when hypertension is superimposed on aging. Hypertension 65:370-7
|Hong, Zhongkui; Sun, Zhe; Li, Min et al. (2014) Vasoactive agonists exert dynamic and coordinated effects on vascular smooth muscle cell elasticity, cytoskeletal remodelling and adhesion. J Physiol 592:1249-66
|Kalogeris, Theodore; Bao, Yimin; Korthuis, Ronald J (2014) Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol 2:702-14
|Sun, Zhe; Parrish, Alan R; Hill, Michael A et al. (2014) N-cadherin, a vascular smooth muscle cell-cell adhesion molecule: function and signaling for vasomotor control. Microcirculation 21:208-18
|Kalogeris, Theodore J; Baines, Christopher; Korthuis, Ronald J (2014) Adenosine prevents TNF?-induced decrease in endothelial mitochondrial mass via activation of eNOS-PGC-1? regulatory axis. PLoS One 9:e98459
|Nourian, Zahra; Li, Min; Leo, M Dennis et al. (2014) Large conductance Ca2+-activated K+ channel (BKCa) ?-subunit splice variants in resistance arteries from rat cerebral and skeletal muscle vasculature. PLoS One 9:e98863
|Fairfax, Seth T; Holwerda, Seth W; Credeur, Daniel P et al. (2013) The role of ýý-adrenergic receptors in mediating beat-by-beat sympathetic vascular transduction in the forearm of resting man. J Physiol 591:3637-49
|Korthuis, Ronald J; Kalogeris, Theodore (2013) TRPing up reperfusion: neutrophil TRPM2 channels exacerbate necrosis and contractile dysfunction in post-ischaemic myocardium. Cardiovasc Res 97:197-9
|Hong, Zhongkui; Ersoy, Ilker; Sun, Mingzhai et al. (2013) Influence of membrane cholesterol and substrate elasticity on endothelial cell spreading behavior. J Biomed Mater Res A 101:1994-2004
|Fairfax, Seth T; Padilla, Jaume; Vianna, Lauro C et al. (2013) Spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting humans. Am J Physiol Heart Circ Physiol 304:H759-66
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Mar 01, 2012, 02.06 PM | Source: Moneycontrol.com
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Ending Discussion Thread - All other threads will be deleted!
I am completely sick of threads on the ending of this game. Discuss it here. Only. Or die.
Did you delete the ones that were already made or just close them...or neither?
Anyway I think the ending is alright besides the magical space child, the fact that the normandy is near a mass relay at the end, and the fact it doesn't really tell me what happens afterwards.
I thought it was confusing at first. I went back and thought about the key elements of the other games. The "overpowering your own indoctrination" thing makes sense.
I say everyone has their own opinion and that's what it is. I destroyed the reapers and was still alive.
I don't know what to make of the old man and boy though.
I think the boy was the reapers trying to get a leg up on Shepard and turn her to the "dark side" so to speak.
Tired of wading through page after page trying to find something else.
This is a a very good idea.
My thoughts on the ending and what will be next are all below.
After watching this video
And this (more expansive) video (http://www.youtube.com/watch?feature...&v=Us4pkLy-PYk)
I can honestly see a DLC being released which begins after you are hit by Harbinger's beam and that everything from that point on in the real game was purely a dream.
An interesting Youtube comment.
"I've been making a list and so far I have over 25 reasons why the indoctrination theory is true. There's just way too much evidence for it not to be true. Bioware is too good at the writing process in order to make all these mistakes, it had to be intentional. They are planning something, and when it happens I think it'll be revolutionary." (A comment from YouTube)
I think he is spot on with what I have highlighted in bold.
I believe that everything which happened after the beam hit from Harbinger was a dream/hallucination and the scene where Shepard takes a breath (under CONCRETE rubble) is him waking up on earth after the dream in the same place as he was when Harbinger attacked the squad trying to enter the conduit.
I think that the true ending wil be revealed in "The Truth" DLC which has been hinted at in various threads across the web. It is also specualted that this will most likely be free to all players with an active Online Pass.
In my opinion this is the only theory which adds up, and as the guy who posted the youtube comment said, Bioware are too good at their writing (as shown in ME1&2) to produce so many plot holes at the climax of their epic trilogy.
EDIT: Link to thread related to "The Truth" DLC. (http://www.xbox360achievements.org/f...ighlight=truth)
EDIT2: Link to GameFront article about "The Truth" (http://www.gamefront.com/rumor-mass-...h-due-in-april)
i just want to know what makes all these people so damn sure that bioware isn't planning some fantastic endgame dlc. Everyone is so quick to just completely discard Bioware now, but if they do release dlc with an ending that answers all the questions from previous mass effect games, then they will be praising them again. The turth is, no one knows what they are planning and no one knows what they are thinking, so just be patient. Until they announce something concrete about the ending I will hold fast my faith in Bioware.
I would take the Truth with a pinch of salt untill there are concrete proof.
Anyways, here's what's happening on the inside currently.
Ive found a couple of more bits supporting indoctronation. James said a couple of times "Can you hear that hum?" A humming noise is one of the first signs of indoctronation.
Secondly somone pointed out the little kid can be seen going into a building just before a reaper blows it up. I havent confirmed this one yet.
Good video explaining
Only problems with giving us the "real" ending through DLC are the people who don't have internet connections - which continues to increase with the worldwide recession - and the point in that recent Game Informer article about the people who might want to play this game in its entirety some time in the future. They will need not only the discs but a system with the ending downloaded. Still, I'm in the wait-and-see camp.
BioWare is not off the hook just by releasing DLC, unless it's free DLC ofc, as I already paid 800NOK (approx $140) to get the N7 edition.
I could accept "ending DLC" if BioWare at least hinted to it in the end, but what we have now are people grasping at straws, over analyzing the hell out of the game, making it up to be something more than it ever was.
i just finished SP and i actually like the ending. To me it's a well constructed Sci Fi ending, that, rather than give you absolute closure, leaves you pondering, not only the trilogy but themes and ideas beyond. I completely understand why many aren't happy, and i would have liked to see some of the aftermath from different character's perspectives but from the beginning, i knew it wasn't going to be a "happy" ending and i'm still holding on hope from the very last scene that my Shepard is still alive.
As for the rumours of DLC endings, if true, i hope it simply fills in some of the plot holes rather than give an alternate ending.
After watching the above video, my concerns about the cut and paste cut-scenes w/o any real closure on your comrades and yourself/universe are somewhat calmed. I do hope he's right (video) and there is a DLC, if not... that sucks.
I just wanna say I'm sick of all the ending videos, because half of the people making them don't even have their Mass Effect facts in order. People are like how in the hell did the Normandy outrun the shockwave at the end if the Mass relays blew up? Remember the part at the end of ME2 where you take the Omega 4 Relay to the Collector base? At the end of the suicide mission they "jump" away out of the Collector base without the aid of a Mass Relay. I'm not saying I'm the authority on fucking ME facts, but it seems pretty obvious the ship contains a drive in which some form of FTL travel is possible. How long it can be maintained or how far it goes is another story entirely but it seems pretty fucking obvious as per usual people are fucking retards and like to bitch about anything, even when they clearly know nothing about the subject matter.
Sorry my rage for people just bubbles over sometimes.
I'm not saying this justifies a new ending. But it's far from this open-ended clever masterpiece everyone's talking about. I'm not even sure I'd want a new ending. If we want people to accept games as art we have to accept what the artists who make them do. Besides, if they wrote an ending this poor I'm not sure they could do better given a second chance.
This should of been done from the start lol.
The dark energy story was better so well done all those people that bitched when it was leaked because Bioware canned it and rushed this crap.
If the Indoctrination Theory is true then Mass Effect 3 could have one of the best endings ever but I highly doubt that Bioware were that deep in the story. Also what happened in the leaked ending, I never read what happened.
I belive Destroy simply killed all reapers in the original ending
I think the ending(s) was/are just fine. Not quite sure what everyone wants or is expecting? Before the ending, did you listen to the child and his 3 choices? Those explain what the hell is going to happen. Destroy the reapers, control the reapers, synthesis organics with synthetics. Each choice goes with their own pros and cons too. I don't recall all the little details of each, and I do wish they would of gave a confirmation before picking what you wanted before you did it, along with a summary of what your choice was going to be.
And for those wondering about the Stargazer and the child at the end? I thought it was obvious. They are both many years (possibly 100s or 1000s of years) in the future and the Stargazer is retelling the story and legend of Shepperd to his grandchild.
The problem is the ending completly ignores everything we have found out upto that point and has No closure.
These are all very valid points. Especially the bonus irritation above me...those questions are EXACTLY what I wanted to have answered.....Damn space child ruined it
Drew Karpyshyyn's original draft for ME3's ending which explained the motivations behind the Reapers. They were supposed to be a union of countless alien races with the first-generation Reapers having discovered in the distant past that Dark Energy (which was alluded to in ME2 during Tali's recruitment mission) was threatening the entire galaxy/universe, and so they preserved themselves in Reaper shells and tried to do the same to 'save' other sufficiently advanced races, while attempting to figure out a permanent solution for untold millions of years, although they were unable to find one up to the present.
When this original script got leaked, fan backlash was apparently so bad that they had to rewrite ME3's ending and so we ended up with this instead, and you know the rest.
IMO, slightly better than what we ended up with but still shite!
Okay why does everyone keep calling it a star child or space child? It is not a child it is the catalyst. It just chose the form of the child Shepard failed to save for some reason. So call it the Catalyst.
All of you complaining about Joker suddenly flying the Normandy away from battle. The battle was over. The Reapers were either being destroyed, taken over or synthesized with organics but doing this resulted in the destruction of the Mass Relays. As any fan of this series has learned from playing the DLC, destruction of the Relays causes them to go Super Nova. So Joker was trying to out run/fly the blast but as we have seen to no avail. As for your squad mates being on the ship, they didn't get there by magic. I'm sure a lot more time passed between Shepard getting knocked out/nearly killed by the Reaper blast to him limping into the beam, being teleported to the Citadel, finally waking up because I doubt he awoke a few seconds after in the shape he was in. Then of course he limped his way to Anderson, then had a lengthy conversation with the Illusive man, a short one with Anderson, then has a conversation with the Catalyst and finally chooses to either control, destroy or synthesize. That is enough time for the Normandy to fly in to pick up your squad mates, especially as Fast and elusive as the Normandy is. As for the Catalyst giving the options to Shepard at the end is because Shepard prove it was wrong about Organics, the fact that he made it that far in the war against the Reapers "its priorities have now changed". Before its priorities were the Reapers have to do what they were doing and Organics had no choice but to submit. It believed that Organics weren't strong enough to escape their fate, that they had no say in deciding their future, yet Shepard prove it wrong based on what he accomplished. So that's why the Catalyst put the fate of the galaxy in Shepard's hands.
That being said, the lack of closure is a problem for me, not a "OMFG This game sucks now Bioware needs to make another ending, I'm never buying another Bioware game again" problem but it did leave me disappointed. I'm not upset over there being no happy ending. Casey Hudson did say Mass Effect 3 was about victory through sacrifice. That's what the endings were, Shepard puts an end to the cycle of the Reapers harvesting and destroying Organic life and saves countless lives from that particular fate. That was the Victory, the sacrifices were Shepard's life and the destruction of the Mass Relays and the results of the Relays being gone. They are pretty much bitter sweet endings instead fairy tale endings that are so common among games and other forms of media. The only real issue I have with the ending is the lack of closure, did my teammates survive then I want to know, did the fleet survive, did they manage to escape the Super Nova. Does someone locate Shepard in time to save him or does he just die alone. These questions could have been answered and Bioware could have still delivered a bitter sweet ending. That is my issue.
Not sure what all the hate on the ending is all about. I was accepting of what happened...well, whatever they want me to think happened. A dlc to further explain it (and delve into the consequences of whatever choice you made at the end) would still be welcome, however.
so people are happy with finishing the story via dlc? You dont mind a BS ending that goes against everything the ME series has been about? EA called they said they love you.
Best Renegade Ending:
Rather than sending an entire fleet in towards Earth, Shepard's forces find about a half-dozen asteroids from the system's belt and hurl them towards the Relay, escaping before collision. Bam: Everything in the system is wiped out, including the majority of the Reapers.
I loved the ending. No other game has left me thinking as much as this one. After first choosing the middle option I thought about it a bit and realised that the game controlled me.... For good I always choose the top option in speech and the blue colour, when the reaper is controlling you it is trying to make u choose what it wants.. Hense the good being first choice and blue. Because your being controlled its the opposite. I preferred what the game classed as the "renegade" option which to me seemed like the good option in the end. So confused but I love the fact that it makes u think so much, no other game has achieved this!!!! :D
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Acute myelogenous leukemia (AML) is one of the most common and aggressive forms of acute leukemia affecting 30,000 people per year. Greater than 5 year survival rate still remains around 10-30%, and this depends greatly on the patient's ability to tolerate the combination of cytotoxic chemotherapies, which suppresses much needed haemopoiesis. The limits of current treatment modalities indicate a need for innovative therapies directed against relevant biological targets in AML to improve the clinical outcome. AML is a heterogeneous disease;recent studies have identified a set of activating kinase mutations in FLT-3, c-Kit, and Ras and constitutively active transcription factors such as STAT5 and chimera MLL relevant to disease outcome. One of the major challenges in treating AML is developing therapies that are capable of affecting multiple biological pathways promoting AML proliferation and survival. Histone deacetylase isozyme 6 (HDAC6) is over-expressed in AML patients and is hypothesized to play a key role in maintaining oncogenic signaling through the regulation of heat-shock protein functions that are critical for AML pathogenesis and survival. HDAC6 is also required for malignant cell transformation both in transformed cells and in vivo. Moreover, HDAC6 knock-out mice have been shown to resist mutagen induced tumors and develop normally, which further underscore the potential of HDAC6 as a better tolerated and less toxic therapeutic target for AML. We have identified novel HDAC6-Hsp domain inhibitors, which preferentially inhibit the HDAC6-Hsp deacetylation domain at low ?M concentration and induce Hsp90 acetylation, unlike the canonical hydroxamate HDAC6 inhibitors, tubastatin A and Tubacin. Our overarching hypothesis is that HDAC6-Hsp domain activity promotes AML proliferation and survival by maintaining proper function of multiple heat-shock proteins. Selective HDAC6-Hsp domain inhibition deactivates multiple Hsp activities, attenuates aberrant AML oncogenic signaling, and promotes AML apoptosis. This proposal intends to use multifaceted and innovative approaches to develop novel HDAC6-Hsp domain inhibitors and to investigate the role that HDAC6 plays in the regulation of Hsp activities and apoptosis initiation in AML.
In Aim 1, we will refine our HDAC6-Hsp inhibitors through a phylogenetic library synthesis in order to characterize the structure activity relationship of the HDAC6-Hsp domain.
In Aim 2, we will investigate the HDAC6-Hsp pathway axis, study HDAC6 dependent Hsp70 regulation, and the roles of Hsp70 acetylation play in apoptosome formation. Finally, we will examine our HDAC6-Hsp deacetylation domain inhibitors in vivo using a physiologically relevant disseminated AML xenograft model. We will determine the efficacy of our lead HDAC6 inhibitor candidates against AML, performing pharmacokinetic and dynamic studies on lead inhibitor candidates, and validate the inhibitor's ability to influence biomarkers in vivo.
Acute myelogenous leukemia (AML) is one of the most common and aggressive forms of acute leukemia affecting 30,000 people annually. With an expected increase in American life expectancy, the numbers of AML cases are also expected to increase, as the majority of AML patients are over the age of 60. Little has changed in the standard AML therapies for the last 30 years, and treatments with low cytotoxicity and high therapeutic windows are highly desirable. By studying molecular mechanisms of HDAC6-Hsp domain inhibition and induction of selective AML apoptosis, the development of novel HDAC-Hsp domain inhibitors against AML can be a significant advancement from the current treatment disadvantages.
|Rahn, J J; Bestman, J E; Josey, B J et al. (2014) Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy. Neuroscience 259:142-54
|Li, Xiaoyang; Inks, Elizabeth S; Li, Xiaoguang et al. (2014) Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity. J Med Chem 57:3324-41
|Zhang, Lei; Zhang, Yingjie; Chou, C James et al. (2014) Histone deacetylase inhibitors with enhanced enzymatic inhibition effects and potent in vitro and in vivo antitumor activities. ChemMedChem 9:638-48
|Fan, Jie; Alsarraf, Oday; Dahrouj, Mohammad et al. (2013) Inhibition of HDAC2 protects the retina from ischemic injury. Invest Ophthalmol Vis Sci 54:4072-80
|Chou, C James; Inks, Elizabeth S; Josey, Benjamin J (2013) Vitamin K: a structural basis for the design of novel neuroprotective agents? Future Med Chem 5:857-60
|Zhang, Yingjie; Inks, Elizabeth S; Zhu, Mengyuan et al. (2013) Discovery of a Pair of Diastereomers as Potent HDACs Inhibitors: Determination of Absolute Configuration, Biological Activity Comparison and Computational Study. RSC Adv 3:
|Zhang, Yingjie; Liu, Chunxi; Chou, C James et al. (2013) Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem Biol Drug Des 82:125-30


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I have 10 KCI 19 15rd mags. 3 are out of wrapper. 7 are still in wrapper.
These are all new. Asking $10 a PC
Last edited by Patrick/GSA; 05-14-2013 at 04:54 PM.
Reason: Need to move these mags
Now 10 bucks a pc
5 sold 5 left
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text:
wowGod used a truck to deliver a kiss from heaven
My husband's truck is his favorite ever. He traded a man for it. For real. Like a long ago "I'll give you 3 chickens for a new wagon wheel" kind of trade. From a craisgslist.com ad, he went to see it years ago. The guy selling it said what he really needed was an old junker truck to use on the farm. The farmer looked at Darin's old junker truck, looked at his truck, they looked at each other - and it was a trade (plus a couple thousand dollars from us since the truck Darin was getting was worth more, fo shizzle.)
So it's been a really great truck for our family. There are four doors (helpful since we have the boys getting in and out of the back seat) and there's a nice short bed (which has been a huge help for moving and for children's ministry and just for life). Pick-up trucks are nice to have around.
About 4 months ago, the driver's side back door started to stick. So our son Jesse had to crawl in through the backseat passenger door and Darin had to unroll the window from the front seat to buckle Jesse in his carseat.
We kept saying - we need to get that fixed!
Months passed.
Then in early December, the driver's door started to malfunction. If Darin locked it, it wouldn't open unless he forced it from the inside. A few times Darin AND Jesse were both crawling in from the passenger side.
At this rate, everyone would be jumping through the moon-roof soon.
So we went to the Ford dealer a few weeks before Christmas to get an estimate. After a full Saturday of Christmas errands, we went back to get the bottom line. Darin said in an uncharacteristically optimistic moment (I'm usually the optimist in this union and he's normally the realist), "Maybe it will be under $200. We have that much in our car repair envelope."
We found out it would be well over $1000, plus they were recommending several other things, as they often do :)
I left Darin at the dealership while they finished up an oil change. We decided to live with the messed up doors for a few more months while we saved up. AGAIN, uncharacteristically, Darin was not bummed out. He said with a smile something like, "God will take care of it." I drove off thinking - wowGod is moving in Darin's life big-time.
Okay, so now starts the big wowGod story for my little heart.
While sitting in the lobby waiting for them to finish, a little girl from our church recognized Darin. So she and her father came over to introduce themselves and chat. In the course of conversation, they discussed why they were there. Darin explaind that we got an estimate on a repair, but we were going to wait until we could save up. The guy asked for details and Darin explained about the doors.
This friendly conversation wasn't relayed to me.
The next morning, I was serving in children's ministry and at the end of the small groups time, there was one little girl who hadn't been picked up yet. She helped me clean some things up, then we started talking. I love any moment I get to go deeper with an individual child because there are so many children at our church - and my goal for 2012 is to know all their names.
I learned her name. I learned that her dad was serving in youth ministry that morning. AND I learned that it was her birthday! So we walked around for a while and I had everyone sing happy birthday to her:) It was fun and sweet because this little girl was so fun and sweet. These kind of moments are my favorites in life.
Then we decided to walk together over to the youth building and find her dad.
When we met up with her dad, we introduced ourselves and chatted for a while. We talked about her birthday party the day before and laughed a lot.
Then he asked, "Are you Darin's wife?"
"Yes, I am."
"Oh, I'm going to fix your truck."
"I'm sorry, what did you say?"
"I'm going to fix the doors on your truck."
I'm going to try and write out what happened inside of me at that split second. First off, how did he know our car was broken? Darin and I don't share stuff like that openly (for lots of reasons, but mainly because we never want to manipulate people into helping us).
Secondly, in that split-second I thought, "Who are you? I don't even know you and you're saying you're going to fix our truck."
Thirdly, my mind reeled because I remembered Darin's faith - "God will take care of it".
Fourthly, it was less that 24 hours later and someone was saying they would fix it.
Fifthly (is that a word?), for the past 15 minutes, I had had a remarkably pleasant experience laughing and singing with his daughter, a precious God's girl.
Sixthly, I was - in a moment - overwhelmed.
So my eyes spontaneously filled with tears and I said, "I'm sorry, I don't understand." Even as I write this, my eyes have filled with tears. I feel it again. How did this virtual stranger have knowledge about my family and how did this "chance" meeting happen with his precious birthday girl, standing out in the sun on a beautiful Sunday morning outside the youth building?!?
He smiled and said he and his daughter had met Darin at the Ford dealership the day before. He said he is skilled in fixing such problems and that he would be taking care of it for us.
I just have to express to you that, for me personally, it felt like a kiss from heaven.
a few days ago, Darin came home from work and told me that his truck doors were all fixed. :)
It's a sweet wowGod moment I hope I never forget.
FYI, God WILL take care of it.


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New York State Prisons & Institutions located inside the GREEN HAVEN HUB - Green Haven, Downstate, Fishkill, Beacon, Taconic, Bedford Hills.
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Fishkill Correctional Facility
Fishkill Correctional Facility
Box 307
Beacon, New York 12508
(845) 831-4800
(Dutchess County)
Inmate Mail:
P.O. Box 1245, Zip 12508
Medium Male
Visitation Hours:
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FRP available: YES There are reserved parking spots for FRP visitors in the small lot next to the regular visiting area.Check-in is btw 10:30 and 11:00 am at the big gate in same lot. Have food bagged and go thru metal detect. Then on the van,thru the gate to the office.Bags go on a table for further processing. Show ID's.Lock up any meds (remind them later that you need to take them..at count times)Bring a quarter for the locker to put your ID's and any non-allowed stuff. On in.You will be called to get your stuff after they process it(around 30min).
The usual no glass,no alchohol content. No Deli products. Must be sealed.Grocery meats(styrofoam/plastic wrapper)OK. Sealed bread to be safe.No shells-on shellfish. There are drip coffee pots there so remember filters,sugar packets best.They provide salt/pepper.Other spices(sealed)ok.
Cookware decent/variety.Charcoal grills(you bring charcoal).Picnic tables for each unit.
Small play area for younger children outside. Some toys/games available in office.Movies to choose from on first nite.You may bring some toys. No battery op. Matchbox cars and a few action figures have been OK.
They provide bedding/toweld. Dr note if you bring your own. Bring dish soap and sponge.
There is a hairdryer provided(whoever asked about those).
The units have been clean and everything in working order both times we have been there.
General Information: thanks jellobean!
Visits are pretty laid back, which is nice. You park at the bottom of the hill and walk up (about a 1/4 mile) unless you are there for an FRP or have a handicapped plate. If you have a package you can drive up and drop it off inside the door and go park (never done it, but I was told to do it by a CO - it's hard to carry 35 lbs of food up a hill for a 1/4 mile!)
Processing starts at 8:30, you go up to the counter and give his DIN# and your ID, and fill out a pass to go back. If you get there later, sometimes its difficult to find a locker (I've never not been able to get one, but a lot of them are broken - they will just spit your quarter right out and are unusable, so you might have to try a few different ones.)
After you get the pass, you go to the package line or the Xray/scanning line (if the lines are long when you first get in, ask people which line you're in - I've totally stood in the wrong line for like 10 minutes and not realized it because they were getting mingled together!) Package lines can get pretty long, especially on the first weekend of the month, just as a warning. They can be strict with some things (depending on the CO).
Depending on the day and the CO, they can be strict about clothes. I've seen people get in and was appalled that they were allowed to wear that outfit in, and I've been made to change my not-very-low-cut t-shirt (which I had worn in/taken in many times before). I always bring an extra t-shirt in my purse that I know will be allowed, but I've only been made to change once. You don't have to take off your bra to go through (they will just wand you if you beep and let you through). Sometimes they will make you take off jewelry/glasses, other times not. You can also bring sealed packs of cigarettes and lighters (as long as they don't have the adjustable flame).
You can bring in like a little clutch purse (doesn't have to be clear) but you can only bring money, ID, locker key, or car key (just the car key, no electronic unlocker or other keys attached). After you are scanned you go out the door and through a "trap" (where they lock the one door behind you before opening the next) and up the stairs and to the left. Once you get to the end of the hallway they check your pass and your handstamp and then you walk down and through the second visiting room (with 2-person tables) to the front room where the COs will check you in and give you a table.
If you are a family member or have more than 1 visitor you will be in the first room (with 4 person tables, you can sit next to each other), if you are just one visitor they will most likely put you in the 2 person tables across from each other. You can go outside, there are benches and picnic tables, and the smoking area is in the back corner.
Food... there is a frozen vending machine, a sandwich machine, snack machine, 2 drink machines and 2 microwaves in the second visit room (also where the ladies bathroom is). Visit room one has a hot drink machine, 2-3 cold drink machines, snack machine, 2 sandwich machines and 3-4 microwaves, I believe. The vending machine people are always there refilling the machines (they will also give you change in $1s for larger bills if you ask). Sandwiches are like $3.50, snacks $0.50-$1, drinks 75 cents for a can or $1.35 for a bottle, usually.
They have a kids area with games, etc. - the inmate has to go in with the kids. They also have coloring and crayons, cards, dominos, pencils and paper, sorry, scrabble, uno, crossword puzzles, etc. at the games desk that you can take back to your table. You can take pictures (inside or outside), they are $2 and you just pay the CO in the click-click room (no tokens or anything).
I've never been talked to about "physical contact" or anything, as long as you aren't doing anything super inappropriate. I mean kissing, hand holding, hugging is ok, at least what I've experienced. When you're outside, they won't let you stand holding each other face-to-face, you have to be next to each other, but that's about it.
Edit: Sometimes, especially in the summer, they will start to terminate visits if it gets too crowded. If it's nice outside, you can volunteer to give up your inside table and just take a bench outside (what we usually do), so we can just stay outside in the sun and not have our visit terminated.
Also, bathrooms can get kind of gross! The ones in the visitors center are usually low on TP, the doors don't lock (either jam it with your coat, or have someone hold it). They usually have bar soap but no paper towels.
The ones in the VR aren't too bad. Never seen them run out of TP but sometimes they run out of soap. Rarely have paper towels but I would just get a paper towel or napkin from by the vending machines. They also have a diaper changing station in the VR bathrooms.
I assumed you were driving, but there are van services that go (see the other posts for more information) or you can take the Metro-North train from Grand Central (Hudson Line) to the Beacon stop, and its about a $5 cab ride from there.
They will usually call inmates to be in their seats for the count around 11:15 and make them stand for the count at 11:30 (count is usually only about 5 minutes). Visits end at 3, and they are only weekends and holidays.
Sorry I don't have any more information on what you can/cannot bring in with a baby/child, since I don't have kids. If you come in with someone else, make sure you both get separate passes if you want to leave at different times.
If you have an inhaler or something, tell them and you can bring that in (they will write it on your pass). You can also bring in picture (not sure of the limit) but they will count them and then you have to bring them all back out (can't leave any with him).
If you have any additional information, you can PM Mrs G.- and it will be added accordingly
I no longer work for PTO and do not have updated information to share
please go to the NY Forum for help from current staff and members!
Good Luck to you!
Last edited by Momma Ann; 03-24-2010 at
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