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|Reviews for False Facades
| Guest chapter 1 . 2/3/2015
Holy shit I had a dream about a guy with Vincent's features and Vincent is my favourite guy name!
| Guest chapter 1 . 2/3/2015
I don't know why but I love stories about girls pretending to be boys, it's so interesting especially this story! I love!
| RainbowJH chapter 30 . 1/28/2015
I love the story. It is very well-written. I won't be able to favourite it as I'm not here on this site.(RainbowJH is my penname on ). Can you perhaps write a one-shot on what was going on in 's mind when she received that call from Vincent and she went to Frank Westlane's house? I would love to read it...now I'm gonna read d sequel:-)
| Muribr chapter 30 . 1/13/2015
Loved the story and will definitely read the sequel. Crestan High has basically enveloped me in its own universe, with its own characters, to a point that I imagined myself in it when not reading. Thank you for the great read and for the amazing new life you placed inside my head; after all, a reader has a thousand lives.
| Guest chapter 30 . 1/8/2015
So worth it! Will is hilarious and I love him. Your sense of humor just stands out and gets me every time. Great story, excellent. Just one det, what happened to Terry?
Thanks for writing this funny, romantic story.
| rie chapter 1 . 1/1/2015
I enjoy reading your story. I have been reading some stories in fictionpress and it turned out that yours is the best. I like the plot, the dialogues, the characters..hillarious. keep up your good work. Regards from indonesia :)
| HunterJumperDressage chapter 30 . 12/24/2014
This was a wonderful story and intrigued me from the very start. I love stories that dress girls up as boys...I guess that's my love of Shakespeare coming out. Anyway, you did a wonderful job with this story and it was a pleasure to read:)
| LadyCarrie chapter 1 . 12/17/2014
Just read this again and I now remember why I loved it so much! Lol
| Lazerkat chapter 30 . 12/6/2014
I see what you did there...wait, the author of this story is Will? That worries me.
This is by far the best FictionPress story I have ever read and I will most definitely read the sequel. :)
| retrospect129 chapter 30 . 10/19/2014
Excellent story, really enjoyed it! You did a really good job of insane Frank!
| jammie.donut chapter 30 . 10/5/2014
Holy crap. This story was beautiful. Just... Wow. It was cute, action-packed and funny (as in 'trying to silently howl with laughter at 3 am while everyone else is asleep but failing because you've rolled off your bed and sent your mum running into my bedroom like there's a fire' sort of funny). I found myself falling in love with all the gang - Sammy and Vincent's hilarious banter, Will's so-called 'colourful' personality, Danielle's general awesomeness - and by the last chapter I genuinely felt like these people, that I've spent a whole night's worth of reading with, are real. I don't know whether it's my 4.30 am craziness or simply my AHHHHHH opinions on this story, but it feels really weird to be going back to school, back to normal life tomorrow, after what I've just experienced here. It takes a bloody talented writer to make someone feel like that. It's... I can't believe that Sammy and Vincent's story is finally over. Although, I've gotta say, I do love the Will-centred twist in the epilogue thing. Thanks so much for writing this! And by the way, if you don't become an author someday, the world will have missed out!
| T.S. Bourough chapter 30 . 10/2/2014
The last paragraphs did it for me, I love Will, he is my favorite character. Once I, reader, learned he uploaded the novel online it made perfect sense why he was such a diva during the entirety of the story.
I don't know if that made any sense.
I decided to read all 30 chapters before writing any reviews, and I simply love it.
What I'm struggling with is with your book's point of view on sexual preferences. Let's take Will's lifestyle, he is open about being bisexual but sometimes his friends don't think his attitude is acceptable. The question that this book raises in me is: what is wrong with being gay, or lesbian, or a crossdresser? I know I don't mind what people's choices are, and you probably don't, but reading in a book that a person cannot accept someone because he speaks openly about his sexuality makes me feel I'm stuck in the past, not looking into the future.
Let me give you an example. Will reminds me of an ex co-worker, for years he would flirt with anyone at the office, we eventually learned to live with his way of showing love, men or women, nobody thought he was crazy, mad, that he had a problem, nor anyone would joke about injuring him, or tell him to be normal. What is normal in the end?
I guess what I'm trying to know is what is your opinion on this, nor personal opinion if you will but from your book's pov, I'm concerned I didn't understand something and got this all wrong.
If this makes sense to you at all, and I cannot stress this enough, I loved it, my favorite part was when Will tried to stop Vincent from going to Sam's room, I can't believe how hard I laughed, I guess it was chapter 17.
I overlooked grammar and spelling errors this time because I would've stopped reading it, it is hard work indeed, and it would've taken all the fun out of it. Besides I'm working on my own writing skills and fighting with my own errors too.
Also I wanna know everything about Will, LOL :)
| evelyn chapter 30 . 9/23/2014
amazing story couldnt stop myself from re-reading it a gazillion times!
| Anonymous Demigods chapter 30 . 8/20/2014
This story is like a modern day Mulan. Except for the reason why she dressed like a boy, nice twist.
| Guest chapter 6 . 8/15/2014
Oh No!


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Wii U News
Nintendo Download 7th January (North America)
Light gun games! Ocean Runner! Discovery! More!
Analysis Assessing Why NX Needs to Take Over From Both the Wii U and 3DS
And why the recent share price drop is illogical
News New 3DS and Monster Hunter Continue to Lead in Japanese Charts
Wii U dips below PS4 but maintains strong sales
News Japanese Games Market Falls To Lowest Point In 26 Years, But Full Picture Remains Elusive
Down 13 percent year-on-year, but digital data isn't included
News Japanese Analyst Claims NX Could Launch As Early As October, Will Eat Into Wii U And 3DS Sales
"Concept" announcement between March and May, official unveiling in June
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News Extended Nintendo Network Maintenance on the Way
Almost exactly two months after the last Direct...
Feature The Biggest Wii U Games of 2016
The Legend of Zelda x2! Star Fox! Pokkén Tournament! More!
Feature Five Key Reveals and Releases That Will Define Nintendo's 2016
It's going to be a big year
Feature Our Staff's Hopes and Dreams for Nintendo's 2016
NX, Legend of Zelda, Mother 3 and more besides
News Get Ready to Add the Octobrush Nouveau to Your Splatoon Arsenal
Ring in the new year with this fresh new paintbrush
News Nintendo Dominates Festive Sales in Japan as 3DS and Wii U Lead the Way
Japanese 3DS hardware passes 20 million lifetime sales
Nintendo Download 31st December (North America)
1080° Snowboarding, Molly Maggot and various discounts
Talking Point 2015 - A Peculiar Year of New, Old and Surprising Nintendo Games
Not quite the expected
Feature How Mario Kart Brought Two Soul Mates Together
The road to true love is littered with red shells
Video Super Mario Maker Gives Us That Excitebike Platformer We Always Wanted, and a Small Update
Birdo is shown off ahead of New Year's Eve release, too

subset: commoncrawl


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Katy Jane Designs - Invitations, Personalised Invites, Bunting, Party Bags, Favours and more
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Results 1 to 3 of 3
- 12-06-2012, 11:10 PM Thread Author #1
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Htc one v - emailing/texting videos
Hi guys,
I'm new to the forum. I just bought an HTC ONE V phone and I'm getting a little frustrated w/ the HTC help, they just told me to use the "trim function". I'm trying to send a 38mb (2 min) video using the email system. I'm using the trim function on the phone to knock down the video into 4 segments of about 9megs each, is that still to large for each segment? I tried to send a 10 second segment of the video to myself and that didn't work either. Any sugestions on how to send the video using an app (email/text) would be appreciated, could I use winzip or some other type compression program, downloaded on my computer, to send it or could I get an app to send it from my phone directly? Any help would be appreciated.
p.s. my carrier is cricket
- 12-06-2012, 11:21 PM #2Banned
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Re: Htc one v - emailing/texting videos
you can use a zip program but i think it depends on your carriers limits. For instance, my limit is 25MB
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Re: Htc one v - emailing/texting videos
You could try uploading your video to your Google Drive, then send it as an attachment via Gmail. Google recently made it possible to attach up to 10 GB (!) to an email via Gmail as long as the data being attached is stored in Google Drive.
How to share - Google Drive Help
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Hotfrog Singapore provides information regarding Focus Thermal Engineering in Singapore. Focus Thermal Engineering is located at 3015 Ubi Rd 1 #03-204, Singapore 408704 and provides Engineering services. Contact them on 6766 6086.
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The UW Bothell First Year and Pre-Major Programs (FYPP) offers Academic Advising to First Year and Pre Major students. First Year and Pre-Major Academic Advisors have the experience and information to help guide students as they navigate through the university. They can explain requirements, procedures, and help plan for a major. They'll discuss how to match interests with opportunities at UW Bothell and how to integrate academic and career plans.
In addition to general advising, FYPP Academic Advisors offer services to Pre-Health students.
For Undergraduate students already admitted to a major, visit the undergraduate and graduate programs list and select your major for a list of resources and additional advisor contact information.
For quick questions visit us in UW1-160.
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The Environmental Protection Agency's settlement of a lawsuit pertaining to ocean acidification could pave the way for greenhouse-gas regulations under the Clean Water Act, according to this article. Under the terms of the deal filed in U.S. District Court in Seattle, the agency agreed to solicit public comment on ocean acidity, including how states could regulate "total maximum daily loads" of pollutants associated with acidification.
Full Story:The New York Times (tiered subscription model)


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Hi, I'm Georgia, and together with my husband Yiannis and the rest of my family we are the owners of the Village Apartments in Mirthios and will try to make your stay a memorable one
Both Yiannis and I are from the village of Mirthios and have always lived here. Our family has been involved in Tourism for many years, both here in the village of Mirthios as well as in the sea resort of Plakias.
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Teleworking for Library and Information Professionals
By (author) Monica Blake
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Teleworking for Library and Information Professionals by Monica Blake
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When you open a project in Adobe Premiere Pro CS6 installed as part of the Creative Cloud, you receive the following error:
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Additionally, when you try to create a project, you only have DV sequence presets available.


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Corkscrew and Sky Jump, Knott's Berry Farm, circa 1980
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Photo from the Knott's Berry Farm Collection, Accession #2006/8.
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Băile Herculane, 8 Complexelor Street
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Băile Herculane is a city in Romania, Caraș-Severin county , with 5,008 inhabitants. It is located in the region(s) Banat, Bánsági-hegyvidék, Oltenia. Nearby attractions are the Cazanale Dunării.
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If you're looking to buy a new 2017 Ford Super Duty as a potential new truck, you'd be hard-pressed to find one more unique than one we stumbled across at a dealership in Texas. According to salesman Trey Roedy at the dealership in Houston, Texas, who posted pictures of the truck on Facebook, this unique Super Duty is on the lot for the low price of $100,000.
If you're looking to buy a new 2017 Ford Super Duty as a potential new truck, you'd be hard-pressed to find one more unique than one we stumbled across at a dealership in Texas. According to salesman Trey Roedy at the dealership in Houston, Texas, who posted pictures of the truck on Facebook, this unique Super Duty is on the lot for the low price of $100,000.
MASSILLON, Ohio – A.R.E. Accessories is offering owners of 2017 Ford Super Duty pickups a complete lineup of fiberglass truck caps and tonneau covers that add function and style to these hard-working trucks. Made to fit all rugged F-250, F-350, F-450 and dually models with all bed and cab configurations, both products provide truck bed storage that will help contractors and outdoor enthusiasts keep valuable gear secure.
Stow, Ohio – Mickey Thompson was presented with a Project Excellence Award by Ford Motor Company at the 2016 Specialty Equipment Market Association (SEMA) Show in recognition of its custom 2017 Ford F-250 Super Duty built by Mike Duval of X-Treme Toyz.
Skyjacker and Matchbox partnered on a cool build for this year's SEMA Show using the new Ford Super Duty F350 as the platform for this Police-inspired tactical truck. Although there's only one of these trucks currently in existence, Matchbox has actually created a replica version of the 4×4 to commemorate the build.
Ford trucks earned top honors at the Texas Auto Writers Association's 2016 Texas Truck Rodeo, with the all-new 2017 Ford F-Series Super Duty – the toughest, smartest, most capable Super Duty ever – being named "Truck of Texas," the most prestigious award given at the 23rd annual competition.
Ford will offer its new adaptive steering technology on the all-new Ford F-Series Super Duty pickup and Ford Edge SUV to make it "easier to steer at all speeds."
Ford says its 2017 F-Series Super Duty lineup will boast the largest fuel tank in the segment at 48 gallons. Ford uses the longer wheelbase and wider track of the new long-box Crew Cab to fit the huge tank between the frame and driveshaft.
Ford unveiled the payload and towing capability of its new F Series heavy-duty Super Duty trucks, claiming the "most towing and hauling capability and the most horsepower and torque of any heavy-duty pickup truck," which includes a whopping 925 lb.-ft. of torque and 32,500 pounds of max towing capacity.
If you're even wanted to see how close a heavy-duty truck can come to rolling without actually trying it yourself, then this new Ford Super Duty video is worth a few minutes of your break today.
Southfield, Michigan – An innovative one-piece front axle shaft seal that permits faster, easier installation and provides superior sealing characteristics on Ford Super Duty 4×4 trucks has been introduced by Federal-Mogul's (NASDAQ: FDML) National® Oil Seals brand. The new, patent-pending unitized seal (No. 710825) is available immediately through National Oil Seals distributors and jobbers.
The new National seal – engineered for Ford F250, F350, F450 and F550 4×4 trucks equipped with Spicer 50 or 60 Monobeam front axles – features a sophisticated, one-piece design that helps provide proper axial alignment during installation to ensure trouble-free performance and longer life. The new design does not require a snap-ring and can be installed by hand.
"Our innovative new unitized National seal is ready to install right out of the box without tools and eliminates the misalignment concerns commonly associated with conventional oil seals for these applications," said Raymond King, director of business development, sealing, Federal-Mogul Vehicle Components segment.


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OfficialXFC - The Next Generation of MMAThe largest independent mixed martial arts promotion on television watch video >>
PFC 9 professional main event between XFC Lightweight Champion Scott "Hot Sauce" Holtzman and George "Lights Out" Sheppard! watch video >>
Casey hits the mats with Scott "Hotsauce" Holtzman for for an inside look at one half of the XFC 22 main event. Here he discusses his training, his opponent Jason Hicks, and Te possibility of meeting watch video >>
BCMMA#10 Main Event - Charlie Leary (Team Crossface) takes on Jason Cooledge (BKK Fighters) for the vacant BCMMA Professional Lightweight Title. watch video >>
Lightweight champion Sittichai defended his title for the first time in the main event of GLORY 36 GERMANY, which took place as part of the GLORY: COLLISION card. He beat Marat Grigorian over five ro watch video >>
BAMMA 23 Night Of Champions Main Event for the Vacant BAMMA Lightweight Title Martin '50 Cal' Stapleton Vs. Gavin 'Warhorse' Sterritt. Held on November 14th 2015 at the Barclaycard Arena, Birmingham watch video >>
BCMMA#13 Co-Main Event - Adam Boussif from Force MMA takes on Charlie Leary from Team Crossface for the vacant BCMMA Lightweight Championship. Visit www.bcmma.co.uk to keep up to date with the UK's watch video >>
MMA H.E.A.T. brings you the complete TUF 22 Finale post-fight press conference from the Chelsea at the Cosmopolitan in Las Vegas, NV. In attendance: UFC President Dana White, Frankie Edgar, Ryan Hal watch video >>
Main Event - Pro Lightweight Title match, 155 weight class: Mike Wilkins (5-1) vs. Robert Hanna (5- 0) watch video >>
BKK Fighters Jason Cooledge takes on Kieran Malone from Dinky Ninjas Fight Team in this Professional Lightweight Title contest. #Subscribe to our YouTube Channel. watch video >>
Headlining GLORY 18: RETURN TO GLORY is the Lightweight World Title clash between reigning GLORY Lightweight Champion Davit Kiria (22-9-0, 7 KOs) and #2 ranked challenger Robin van Roosmalen (32-6-0, watch video >>
From BAMMA Fight Night: Askham Vs. Nunes is the main event of the evening for the BAMMA World Middleweight Title. Scott Askham (c) Vs. Max "Power" Nunes held at the O2 Guildhall Southampton on 8th J watch video >>
Xtreme Fighting Championships (XFC) - The Next Generation of MMA Televised Nationwide | www.XFCMMA.com Follow us daily on Facebook, Twitter, G+, Instagram, Pinterest, & more.... watch video >>
OfficialXFC - The Next Generation of MMA The largest independent mixed martial arts promotion on television watch video >>


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Rarely is there a discussion of California wine country without that tired comparison being made between Sonoma and Napa counties. Yes, Napa has the glitz, the glamour, the star chefs and stellar Cabernets -- and along with it the crowds and high prices. Sonoma, on the other hand, cherishes its laid-back reputation and its (relative) affordability, though its many excellent wines could be better appreciated.
So let's stop right there, and throw out some numbers. Napa boasts around 450 wineries; its neighbor, less than half that. But what Sonoma lacks in quantity, it makes up for in variety. At 1,600 square miles, Sonoma County is twice the area of Napa, and is made up of 12 regions that vary greatly in terms of terrain, climate and grape varietals.
Closest to San Francisco (about 30 miles) and bordering Napa are the Sonoma Mountain and Sonoma Valley regions. Thanks to its dry climate, the area produces robust Zinfandels and Cabernets and fruity Chardonnays, and its undulating golden hills are a sight to see at sunset. This is where you'll find the largest concentration of wineries (more than 40) and some of the biggest names in California wine: Ravenswood, Gloria Ferrer, Cline Cellars, Schug, and St. Francis among them. Benzinger, one of the few bio-dynamically produced wines, is located in Sonoma Valley, in the tiny town of Glen Ellen.
Stay in the town of Sonoma itself, a peaceful little enclave in the center of which is the historic town plaza, dominated by an grand early-20th-century stone City Hall. Surrounding the square (designated a National Historic Landmark) are colorful, Mexican Colonial-style buildings housing smart boutiques, restaurants and even a classic 1930's movie house, the Sebastiani Theatre, its ticket booth manned by a stylish mannequin.
Locals will point you to the New Haven-style pizza at The Red Grape, just off the plaza. If the weather is agreeable, head to the quiet back patio for a pizza -- try the Fig & Goat Cheese ($14.25) or the Margherita ($12.75); complement it with one of the 30 or so local wines available by the glass (starting at $6.50). If beer is more your thing, Murphy's Irish Pub, tucked away in a courtyard off the main square, has plenty on tap (including the Petaluma-brewed Lagunitas IPA). It can get rowdy at night, with live music and outdoor seating that fills up quickly with townsfolk sipping on 20-ounce Imperial pints ($6).
Lay your head at one of two boutique hotels: the 16-room, rustic Sonoma Hotel (home to the famous the Girl & the Fig restaurant) or the El Dorado Hotel, where several of the 27 sleekly designed rooms have balconies overlooking the plaza. Rates at the Sonoma Hotel start at $115; at the El Dorado rooms start at $175.
For a completely different experience, head about an hour northwest into the Russian River Valley, where the climate becomes noticeably cooler and damper, and more conducive to growing delicate grapes like Pinot Noir, or Chardonnay (for sparkling wine). Two-lane rural roads connect the many of the valley's wineries, which share space with pine, oak and redwood forests, apple orchards and of course, the 110-mile-long river itself. (Iron Horse, Korbel and Sonoma-Cutrer are some of the well-known wineries scattered throughout this scenic region.)
Santa Rosa is a good base for visiting area tasting rooms, thanks to its proximity to Highway 101, which cuts north through the Russian River Valley. Our pick for hotel is the 50s-era Flamingo Conference Resort & Spa -- easy to spot thanks to rotating pink neon flamingo -- which boasts a huge outdoor pool and live music in the kitschy cocktail lounge. Rates start at just $109. (Beware: it's a magnet for wedding parties on weekends.)
Another historic Santa Rosa spot is Stark's Steakhouse, located in downtown's Old Railroad Square. This 1906 structure, formerly a hotel and later Italian restaurant, was recently turned into a warm, cozy steakhouse and bar by successful area restauranteurs Mark and Terri Stark. Classic steakhouse decor -- dark leather booths, deep wood accents and a roaring fire -- are a showcase for the in-house dry-aged Certified Prime Black Angus beef, which ranges from $31 to $39, depending on the cut.
A 10-minute drive north of Santa Rosa is the town of Fulton, where you'll find the Kendall Jackson Wine Center, just off the on Highway 101. The European-style château surrounded by immaculately groomed shrubbery, rose bushes and culinary gardens with Italian, French and American herbs and produce. Visit the tasting area and tour the gardens, or better yet, enjoy a seated wine and food pairing ($25) with dishes created from the fruits and veggies harvested on site.
There's also a fair share of smaller, artisinal wineries worth a visit. Like the little-known Foppiano Vineyards, Sonoma County's oldest family-owned winery, founded in 1896. Foppiano doesn't make a whole lot of wine -- growing mostly Petite Sirah and Sauvignon Blanc in small quantities -- but what it does bottle is quite tasty and fairly priced (from $15 to $25). And a bonus, tastings are free!
Foppiano is just south of Healdsburg, a ritzy town that feels more Napa than Sonoma. The town plaza, with its impressive towering redwoods, is ringed by fancy art galleries, upscale clothing boutiques and kitchenware shops, and most notably, the two-Michelin star restaurant Cyrus, as well as Charlie Palmer's Dry Creek Kitchen.
Eight miles north of Healdsburg, in the northernmost part of Sonoma County, is the Alexander Valley region, which, during the day, is one of the warmest places in Northern California. At night, however, it cools off considerably, which produces distinctive reds in the Bordeaux style, as well as French Syrah and Italian Sangiovese.
Alexander Valley's most famous winery is also its newest, the 88-acre Francis Ford Coppola Winery, near Geyserville. Where most tasting rooms in Sonoma keep a low profile, Coppola's isn't afraid to be showy .¤.¤. in a very show business kind of way. The Hollywood memorabilia on view -- including Vito Corleone's desk from "The Godfather," costumes from "Dracula," and an actual Tucker car parked on a rotating stage -- nearly takes precedence over the wines.
Then there are the winery's outdoor swimming pools (complete with cabanas) set to open later this month after extensive construction delays. It's been called "water park meets wine tasting," but don't dismiss the delicious, hearty Italian fare at the winery's restaurant, Rustic, with recipes culled from Coppola's family cookbook. Spaghetti Pomodoro ($11) and Mrs. Scorcese's Lemon Chicken ($24) are standouts.
Since Sonoma County covers such a vast area, a great way to experience the diversity of its wines is by having them all in one place. Fortunately, there's no shortage of festivals and tasting events here. The largest is the Taste of Sonoma (usually held over Labor Day Weekend) with more than 150 wineries pouring thousands of wines under three huge tents, and 60 local chefs offering tasty pairings.
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The PI, Robin Felder, Ph.D., with the assistance of the Administrator, Beth McGrath, will provide routine management of the Program Project Grant from this core. The fact that Beth will be also working on Project 1 as a seasoned Research Assistant will provide unique continuity between the laboratory and administrative office. The core will oversee the finances of the project. It will allocate resources and finances to the individual subprojects and cores. It will provide a monthly financial review for project and core leaders. It will undertake the documentation and processing that is required for tracking of the expenditures and changes in personnel. The core will process purchase orders and service contracts for the project leaders. It will provide expert editorial assistance for preparation of manuscripts for all the principal investigators. It will convene the internal and external scientific review groups. It will handle the travel arrangements for the external review committee members and the remuneration for their expenses. It will schedule investigators'meetings and seminars and arrange for visiting professors and their itineraries. The Administrative Core will be responsible for the preparation of reports and summaries that are required by the NIH for administrative review. It will have a full time staff person to conduct statistical analyses for the data generated in the projects, and the final data sets will be kept on a secure web site to allow all PPG participants to view and comment on the ongoing productivity.
The Administrative core is the central coordinating site for all the projects to assure there is an adherance to our core specific aims, and to facilitate communication, documentation and publication.
|Armando, Ines; Konkalmatt, Prasad; Felder, Robin A et al. (2015) The renal dopaminergic system: novel diagnostic and therapeutic approaches in hypertension and kidney disease. Transl Res 165:505-11
|Lee, Hewang; Abe, Yoshifusa; Lee, Icksoo et al. (2014) Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. Kidney Int 85:561-9
|Gildea, John J; Shah, Ishan T; Van Sciver, Robert E et al. (2014) The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. Kidney Int 86:118-26
|Yu, Peiying; Sun, Min; Villar, Van Anthony M et al. (2014) Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells. Cell Signal 26:2521-9
|Chen, Ken; Fu, Chunjiang; Chen, Caiyu et al. (2014) Role of GRK4 in the regulation of arterial AT1 receptor in hypertension. Hypertension 63:289-96
|Gildea, John J; Seaton, Joscelyn E; Victor, Ken G et al. (2014) Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells. Clin Biochem 47:89-94
|Yang, Yu; Cuevas, Santiago; Yang, Sufei et al. (2014) Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production. Hypertension 64:825-32
|Jiang, Xiaoliang; Konkalmatt, Prasad; Yang, Yu et al. (2014) Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells. Hypertension 63:e74-80
|Yu, Peiying; Han, Weixing; Villar, Van Anthony M et al. (2014) Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells. Redox Biol 2:570-9
|Armando, Ines; Villar, Van Anthony M; Jones, John E et al. (2014) Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation. FASEB J 28:1422-34
Showing the most recent 10 out of 88 publications


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Great Reception Chairs!
Your review: We got three of these chairs for our reception area and love them! They are comfortable, affordable, and professional. We have gotten a lot of compliments on them. They were little difficult to get together at first, but a screw gun made it a lot easier.


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Daily Flights to Haneda Airport, Tokyo Start on 3rd June 2013
DUBAI, U.A.E., 28th January 2013: Emirates, one of the world's fastest growing airlines, announced on Monday that it is increasing its commitment to Japan with the launch of daily, non-stop flights between Dubai and Tokyo International Airport (Haneda Airport) on 3rd June 2013.
Haneda Airport is located in Ota-ku, Tokyo and handles the majority of domestic flights to and from Tokyo; it opened its doors to international carriers following the opening of the fourth runway and the international terminal in October 2010.
Haneda, which will become Emirates' 131st destination, is currently ranked as the second busiest airport in Asia.
Operated by a three-class Boeing 777-200LR, EK312 will depart Dubai at 0935hrs and arrive at Haneda Airport at 0001hrs the following day. The return flight, EK313 will depart at 0130hrs and arrive at Dubai International Airport at 0705hrs.
"As Emirates' third gateway in Japan, the Dubai to Haneda route will help to build on the vibrant relationship between the United Arab Emirates and Japan, in terms of trade and increasing the opportunities for business and tourism," said Thierry Antinori, Emirates Executive Vice President, Passenger Sales Worldwide.
"Emirates has been operating to Japan since 2002 when we introduced non-stop flights to Osaka; our commitment continued when we launched flights to Narita International Airport in 2010. We are confident that the demand in terms of both passengers and cargo is strong enough to warrant Emirates operating non-stop, daily flights to both of Tokyo's airports, offering our passengers more flexibility on the route to Dubai and onwards to over 70 destinations in the Indian Ocean, Middle East, Africa and Europe," added Mr Antinori.
Emirates' longstanding partnership with Japan Airlines will be expanded to include a code share on the new Dubai-Haneda-Dubai services. The flights will be identified with the Emirates 'EK' code as well as with Japan Airlines 'JL' code.
With the new daily flight to Haneda, Emirates SkyCargo is able to provide an additional 210 tonnes of cargo capacity per week, further supporting Japanese exports of mechanical components, electronic goods and automobile parts, and its imports of gas and oil products. Dubai is an important hub for the re-export of Japanese manufactured products to the Middle East, Africa and Central Asia.
Passengers will enjoy unrivalled comfort and amenities on board Emirates' Boeing 777-200LR which is equipped with eight luxurious private suites in First Class, 42 of its latest lie-flat seats in Business Class, and generous space for 216 passengers in Economy Class, along with gourmet cuisine in all cabins which has been tailored to Japanese passengers, served by Emirates' multinational cabin crew.
The aircraft also features ice, Emirates' award-winning inflight entertainment system which offers over 1,400 channels of movies, TV and game entertainment on demand, which includes 40 Japanese channels
With a fleet of 196 aircraft, Emirates now flies to 128 destinations, having launched services to 15 destinations in 2012, Warsaw and Algiers are set to join the network this year on 6th February and 1st March respectively.
Emirates Holidays, the airline's tour operating arm, offers holidays to Japan, with itineraries that highlight attractions in Tokyo, Kyoto and Osaka. Emirates Holidays provides holiday options that take travellers from Tokyo – the modern capital city; to the majestic Mount Fuji and the natural beauty of Hakone; to Nagoya and Kyoto, the cultural heart of Japan; and to Osaka, gateway to the Kansai region.
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Are you looking for roman blinds in East Sussex? Hotfrog showcases more than 20 popular businesses related to roman blinds in East Sussex! Find a specific region or suburb using the left navigation.
Brighton, East Sussex
BellaVista of London / Brighton and the South East UK are experts in the manufacture and installation of . We supply and design high quality …
More info
Hove, East Sussex
We design, make and fit handmade made to measure curtains, fabric
blinds, venetians, shutters and soft furnishings. Whether a simple roman
blind …
Eastbourne, East Sussex
Blind Design will be celebrating 21 years in business during 2010. During this time they have grown from very humble beginnings into what they are to…
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Peacehaven, East Sussex
The Real Curtain Company Made to Measure Curtains, Roller Blinds, Venetian Blinds, Roman Blinds & Vertical Blinds Bespoke made to measure curtains and blinds at a fraction of the high street price. At the Real Curtai…
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Suplier and installer of awnings, blinds, transporter awnings and giant umbrellas throughout the UK. BBSA British Blind and Shutter Association, Roller blinds, vertical blinds, venetian blinds, shutters, interior shutter…
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Crowborough, East Sussex
Established since 1988 Ashdown Blinds serves East Sussex, West Kent & South East Surrey. Free advice, free quotes, exceptional service, high quality and value for money have helped Ashdown Blinds become what they are…
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Burwash, East Sussex
With nearly 30 years of experience I specialise in interior design, hand-made curtains and blinds, soft furnishings, lighting and upholstering and restoring furniture.
I believe that I offer expertise and professional…
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Brighton Sunblinds is a manufacturer and supplier of quality shutters and blinds in Brighton, Sussex region. We have vast range of shutters and blinds. We also offer blinds and shutters repair services. For quality blin…
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Established since 1984 with an enviable reputation I have been an interior designer working with clients, combining my experience and knowledge with their tastes and ideas and we have produced many unique schemes. I wo…
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Seaford, East Sussex
Here at Sussex Window Blinds we have been supplying made to measure blinds for meny years. We have gained an enviable reputation for supplying a high quality products with an excellent service to match. All of our produc…
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New Light Interiors has been a recognized name London, Brighton, Hampshire and Berkshire curtains and blinds industry for over 10 years. New Light Interiors carry a range of fabrics for curtains, blinds, cushions and oth…
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Hailsham, East Sussex
Concept Textiles bring style, colour and inspirational contemporary fabrics that adds a luxurious feel to any room. Our current versatile range of products offer modern colours and designer fabrics at realistic prices fo…
tie backsdesigner fabricsMade To Measurecurtains
Manufacture and supply of Blinds, Awning and Canopies, Brite Blinds supply and fit a wide range of quality blinds and awnings at competitive prices in the Brighton, Hove and Worthing areas. Our range of blinds consists o…
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Danehill, East Sussex
Curtain and blind specialists for quality contract curtaining and window blinds for commercial or domestic use. Fire retardant and anti blast materials available for specialised requirements
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Having been in business in Sussex on the South Coast for over 35 years we are a well respected and established company, renown in the industry for our quality of product and have previously been members of the Briti…
Seahaven Blinds is a family run business which offers a fantastic range of blinds. Selling everything from verticals, venetians, wooden venetians, through to roller blinds nationwide
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Uckfield, East Sussex
Here at Uckfield Blinds we have a strong passion for window blinds, and we enjoy passing this on when meeting our customers. Every appointment is a new and exciting challenge, a re-visit to a previous customer, and a cha…
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Katie Sillett of Curtains by Katie, Seaford, has been making hand-sewn, bespoke curtains, blinds and pelmets for 25 years. Working from her home studio she keeps her overheads low and is able to offer superb quality at …
pelmetscurtain making
Brighton Carpet Centre specialise in supplying and fitting a wide range of domestic and commercial Carpets, Natural flooring, Vinyls, Amtico, Karndean, Project Floors, Marloleum and Rubber flooring for use in living room…
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Bexhill-on-Sea, East Sussex
Harmony Blinds is a renowned company in the window furnishings industry specialising in Blinds, Awnings and Canopies We offer the whole window treatment collection for Awnings, Canopies, Wooden and Aluminium Ve…
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Willingdon, East Sussex
It has been incredibly successful so far and as well as featuring wooden venetian blinds, we are constantly adding new fabrics As a family run business we are proud of our friendly and efficient service
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Bexhill-on-sea, East Sussex
We offer an enormous selection of products, which range from simple designs in gentle colours to bold patterns, printed onto vibrant fabrics Our dedicated customer service team is available to answer any query …
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Prima Awnings are one of the UK's leading blind and awning manufacturers Prima Awnings Eastbourne Sussex Blinds Awnings For further information on the Prima Awnings systems and use of textiles in blinds an…
Brighton and Hove, East Sussex
Blinds Information lists information on the various types of blinds available with links to more information and places of interest.
Can't find roman blinds company near near East Sussex? Let us know by adding the missing business here.
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Brazilian coach Dunga holds his team's training session at the Johannesburg's Hellis Park stadium on June 24, 2009. Brazil will face the South Africa team on June 25, in the Confederations Cup semifinal match. AFP PHOTO / VINCENZO PINTO


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Ordered this several weeks before Halloween. Received email after I ordered it that it was on back order. Have not heard anything since. Halloween has come and gone.
This costume was really a hit! I got 2 "XL" and they fit my 75lb dogs perfectly. I didn't notice that the bones glowed at all but there really wasn't a time when we needed them to so it was cute anyways. Would definitely recommend to others!
I would love to review this product, however, I never received the product I ordered. I was sent the wrong product while this one was backordered. I am still waiting to receive it... 2 months later
not only is it adorable but its also good quality!
Its like a jumpsuit, that's light and "movable" the dog is able to actually wear it. not just for Halloween.I was very pleased with it,the head piece however is tad too big for my dog
(He is a chinese crested and is 9lbs) I simply sewed it to his size but other than that Im very happy with this purchase. The costume I received DOES glows in the dark,and makes it safe also looks pretty cool at night.My dog seems to love it.I definitely recommend this product.
The size chart -small IS accurate and true to it's size.
great, my dog love going around and having all the attention
Good construction. A little short for my dachshund, but the medium was WAY too big. I like the glow in the dark feature.
I also bought the skeleton costume for my Howie too. He is a white Malti Poo so the costume looks great.
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This is the January 30, 2013 news archive. View today's Panthers rumors and news.
Carolina Panthers
Carolina Panthers News and Rumors
Smith optimistic about new coordinator Shula
charlotteobserver.com profootballtalk.com Updated Jan 30, 2013
Veteran wideout Steve Smith knows the Panthers? new offensive coordinator, having worked with Mike Shula the past two seasons.Click to Continue »Share Tweet
Carolina Panthers face uphill push for state moneyIt could be a tough game for the Carolina Panthers to persuade the state of North Carolina to give them as much as $62.5 million toward a planned $250 million…Click to Continue »Share Tweet
Ravens receiver Jacoby Jones was almost a PantherJacoby Jones, a New Orleans native, visited Charlotte last spring on a free agent tour and was set to sign with the Panthers. But after his agent encouraged him to…Click to Continue »Share Tweet
House Speaker Tillis: No direct state money for Carolina PanthersN.C. House Speaker Thom Tillis said Tuesday he cannot support using state tax dollars to renovate Bank of America Stadium, but he left open supporting a local tax hike to…Click to Continue »Share Tweet
Ryan Kalil Has No Regrets About July Full-Page Super Bowl Predictionpanthersgab.com Jan 30, 2013Ryan Kalil sure doesn't seem to have any regrets about taking out that full-page Super Bowl ad back in July. Panthers center Ryan Kalil took out a full-page ad in the Observer in July predicting the Panthers would end their season in New Orleans, hoistiShare Tweet


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I am SO relieved to find that Noreen and Pam have come thru' this
OK...hopefully Scottie as well AND her house and boat. My ex SIL
lives in Alvin - she headed to Huntsville where my niece goes to
college - and they all appear to be OK, plus, hopefully, their house
is gonna be OK as well when she gets back to it.
Can't believe you haven't gotten a good soaking rain out of this
Pam...that would be too much; maybe it will still come as weather
person said storm is sort of just sitting over the borders of TX, AR
and LA....
Important thing is that the gang's OK!!!!!
Marge Talt, zone 7 Maryland
Editor: Gardening in Shade, Suite101.com
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ORIGINAL VINTAGE 1927 MATHER WORK INCENTIVE POSTER -COMING - TRUMPETERS(117 views)
Description: This is an original poster as printed in 1927 by Mather & Co. of Chicago as a work incentive poster. It is one of 78 posters created by Mather in 1927 and it symbolizes a special era in communicating and motivating domestic employees. They were intended to encourage productivity and performance. This particular image was the cover piece for the year 1927 announcing the Coming series of posters. This is an Original Vintage Poster printed using stone lithography; it is not a reproduction. This poster is conservation mounted, linen backed, and in excellent condition. We guarantee the authenticity of all of our posters.
Dimensions: Approx. 37" x 48"
Artist or Maker: ANONYMOUS
Date: 1927
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Edit: Ha - looks like I'm not the only one! ^
- Posts: 312
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Edit: Ha - looks like I'm not the only one! ^
I want to add another shoe to my rotation but not sure which one to get.
I currently have a shell burgundy macneil, black ecco shoes(meh).
I am itching to get another pair of shell cordovans. The shoe bank has a pair of burgundy and brown shell park avenues.
I can't find any live pictures of the brown ones and the burgundy pictures vary widely. The pictures on AE site does not look like true representation of the shoes.
Which color should I purchase? My other option is to wait and get the brown shell strands.
mikeharo: The 2 for $300 sale occurred around a month ago.
These are my McTavish shoes in Natural Tan plus a couple coats of leather conditioner. I notice the dark cognac is popular here but if you're looking for a brighter and more casual look these get the job done. They have a red hue and go well with jeans or cords. They are probably too bright for navy.


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1. "The altar is Parganya (the god of rain), O Gautama; its fuel is
the air itself, the smoke the cloud, the light the lightning, the
coals. the thunderbolt, the sparks the thunderings.
2. "On that altar the Devas offer Soma, the king (the moon). From
that oblation rises rain.
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Lot 165: 165. English "The White Horse"Pub Sign
Country, Americana, Steampunk, Machine Age & Advertising Auction
by Haw River Junktion, LLC
December 3, 2016
Graham, NC, USALive Auction
Past Lot
Looking for the realized and estimated price?
Description: Vintage "The White Horse"Â English Pub Sign.This beauty could be from any number of pubs that dot the English countryside. Wood with metal frame. Â Two sided. Dimensions: Â 36.5"w x 48"h
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text: st. louis university Saint Louis University Plans Human Trial for Zika Vaccine By Associated Press • Jun 23, 2016 turkletom / flickr Saint Louis University will begin a human clinical trial this fall for a vaccine that seeks to prevent the Zika virus. The university said Thursday that funding from the National Institutes of Health will fund the trial. Lead researcher Dr. Sarah George says the goal is to make sure the vaccine is safe and then measure the immune response to Zika. The vaccine contains an inactivated version of the virus. After testing in St. Louis begins, the university plans a second study in Puerto Rico, which has been hit hard by the virus. SLU Students Help NASA Ozone Study Soar Over Saint Louis By Véronique LaCapra • Aug 22, 2013 If you happen to be near the Saint Louis Science Center planetarium at around 2 o'clock in the afternoon, look up. You might see a weather balloon. Students at Saint Louis University are launching them as part of a study sponsored by the U.S. space agency NASA. The mission aims to improve our understanding of air pollution and global climate.


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4pages onAdd New Page
this wiki
this wiki
Welcome to the Sir, You Are Being Hunted WikiEdit
Open alpha was launched on August 19th 2013 by the studio Big Robot of just 3 developers, so let's help them out creating a comprehensive wiki of robots, items, and strategies to survive and thrive in this unforgiving world!
About the gameEdit
Sir, You Are Being Hunted is a first-person survival and stealth game where you must find twenty-five artefacts to escape a bunch of deserted British Isles while robots try to hunt you for sport.
The alpha can curently be purchased for $20 USD from Big Robot's Website through Humble Bundle or directly on Steam
Launch TrailerEdit
Latest activityEdit
- Rifle
edited by A Fandom user
Summary: General information:
- Welcome to Sir, You Are Being Hunted Wiki!
comment by A Fandom user
- Talk:Rifle
new comment by A Fandom user
Comment: Actually, the most powerful weapon in the game is the blunderbuss. I think they should add a musket.
- Talk:Rifle
new comment by A Fandom user
Comment: I dont think the rifle is the most powerful weapon in the game, I think its dynamite.
- Shotgun
edited by A Fandom user
Summary: Ammunition:
- Category:Overview
edited by A Fandom user
Summary: Removing my test
- Category:Overview
created by A Fandom user
New page: asdasdasd Summary: Just testing how this works.
- Sir, You Are Being Hunted Wiki
edited by Pseudobread
Added video:
- Shotgun
edited by Doomdude1
Summary: Expanded article
- Binoculars
created by SaltedPony
New page: The binoculars are an equippable item found at the beginning of the game, but can also be found by exploring. The mousewheel is used to zoom in and... Summary: Created Binoculars page and added a picture. Added photo:


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This paddle leash is perfect for securing your paddle during photo opportunities, snack breaks, or windy passages. Long enough for use while paddling, but small enough for easy out-of-the-way storage. Assorted colors.
|Item #:
|42 in / 106.68 cm
|Part Number
|Assorted Colors
Great Price, Great Product. I'm over 6'2" and have fairly long arms--the length is perfect for comfortable paddling and storage.
I broke the end off the second time out. Probably my fault. I made a live basket leash out of it so it turned out pretty good after all.
I really like this paddle leash. It's simple, fool proof, and sturdy. If you dump your yak it keeps the paddle close (a feature my wife loves...) In addition to keeping your paddle tethered, you can attach other items (i.e. water bottle, etc.) that you have loose on deck. Can't beat the cost.
Tried this paddle leash in mild conditions today - but it is too short. I am 6ft 4in and a stern rudder manoevre is not possible. I need to extend it myself by about 1 ft.


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Writer for specific technical Articles wanted
- Status Closed
- Budget $30 - $250 USD
- Total Bids 7
Project Description
I am looking for writers who can write proficiently in the English or German language and have a strong technical background.
My company is working in the field of selling material for milling, turning or drilling ( steel, titanium, aluminium etc. ) especially for prototype builders and private persons as well as the tools to do this.
Another main part of our business is cnc – technique for building mills, turningmachines, saws … as well as manufacturing the main construction parts to build these machines.
I am looking for writers who can write technical "how to" articles either by their own knowledge or by intensive research.
The first project will be several Articles on how to turn different Materials, Forms, angles etc. on a lathe.
As the size of the articles varies from text to text
Only those fluent in American English or German and grammar!. I need qualified writers that are capable of producing top quality content. Prior experience in the same field is important.
Plagiarism is NOT acceptable, of either online or offline works. We will check originality through several programs such as Copyscape, Plagisoft and others. I expect you to run the articles through online copy checking websites &/or software prior to submission.
Please provide me with samples of previous work when applying, especially related to the technical content described earlier.
If this works out well and I am happy with the finished work, I intend on using your services on a regular basis.
I will own exclusive and complete copyrights to all article content once delivered and paid. You may not distribute the articles in any way after delivery to me. Once I pay for the Articles I will own ALL publishing rights.
I will Pay through escrow upon completed work.
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Reward brand-desired behaviors while collecting personalized and actionable data.TRY DEMO
"Our recent Billow promotion numbers almost tripled our most optimistic projections, resulting in 15,500 new email addresses and nearly 100,000 targeted consumer actions. We're amazed at the speed and effectiveness of their platform. Customer service was outstanding. Very responsive to all questions and providing stats. Plus the team is fun and easy to work with."
– Road Runner Sports
Billow Engagement's gamification solutions are based on the client's needs and goals. Billow has built proprietary tools and features which allow us to create engaging campaigns which help clients achieve their goals.
Billow's gamification marketing campaigns can be integrated with existing marketing and can help leverage existing databases and fanbases. Billow campaigns can also integrate with loyalty programs via API integration.
Billow Engagement has a proven record of helping clients achieve their goals all while increasing consumer engagement with the brand. We get and keep consumers' attentions while encouraging brand-desired actions.
Billow gamification campaigns are ideal for companies looking to engage social media followers as well as mobile consumers. ``Text-to-Play`` feature makes it easy for mobile consumers to play!
Consumer Interactions


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The Nike Pro Women's Training Capris are made with sweat-wicking stretch fabric for a comfortable fit and locked-in feel during intense workouts. A lined gusset and ergonomic seams offer enhanced range of motion.
Thank you for visiting Nike Womens Pro Capri - SU15 Running Tights on oakleysbikes.co.uk
We bring the products from many websites to one website for you to search, save and compare.


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Roulette Kemer 5
Find Hotel Rates
Recent Searches
Wego searches multiple travel sites so you can find and compare the best rates.
Roulette Kemer 5 Hotel Reviews
Based on reviews from across the web.
Roulette Kemer 5 Hotel Details
Kemer is a small resort approximately 45km west from the city of Antalya and 60km from the airport. There are a number of smaller resorts in its' environs, dotted along the coastline. The Taurus Mountains back onto the coast here and create an impressive backdrop to the resorts and hotels which mostly look out over the turquoise Mediterranean. The beaches in this area tend to be pebble and gently shelve into the sea. Kemer has a good choice of shops, a marina, open-air nomad museum and a number of cafe bars and restaurants. Under the 'Roulette' system, the customer receives a considerable discount on the price. The name of the hotel is revealed a minimum of 72 hours before the arrival date and the customer is guaranteed accommodation in the requested category and destination. Any modification on the part of the customer after the initial reservation is made could change the conditions of the offer.


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For Manuscript Submission, Check or Review Login please go to Submission Websites List.
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|Table of Contents
|Vol. 36, No. 4, 2012
Issue release date: October 2012
|Section title: Original Report: Patient-Oriented, Translational Research
Prevalence of Cardiovascular Events in Patients with Autosomal Dominant Polycystic Kidney DiseaseHelal I. · Reed B. · Mettler P. · Mc Fann K. · Tkachenko O. · Yan X.-D. · Schrier R.W.
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colo., USA Corresponding Author
Robert W. Schrier
University of Colorado Denver, Division of Renal Diseases and Hypertension
Box C-281, 1270 East 19th, RC2 7th floor, Room 7001
Aurora, CO 80045 (USA)
E-Mail firstname.lastname@example.com
Background: This study evaluates the prevalence of cardiovascular events in autosomal dominant polycystic kidney disease (ADPKD) patients. Methods: We distributed surveys to 1,439 subjects from our ADPKD research database. In total, 426 subjects completed and returned surveys; 7 of these were from children and were excluded from the study. Results: The patients who responded were female (63.2%), nonHispanic (88.1%) and white (93.6%). The mean age of the total group was 53.2 ± 13.7 years; 82.8% had a family history of ADPKD and 32.5% had reached end-stage renal disease (ESRD). With respect to cardiovascular risk factors, 86.6% were hypertensive with a mean age at diagnosis of 36.9 ± 12.9 years and hypertension was significantly more prevalent in males. In addition, 19.6% of the subjects were obese, 20.8% were smokers, 8.7% had diabetes, 45.7% had high cholesterol and 17.8% were sedentary. The most prevalent self-reported cardiovascular events were arrhythmias (25.9%), evidence of peripheral vascular disease (16.5%), heart valve problems (14.4%), cardiac enlargement (9.5%), stroke or cerebral bleeding (7.5%), myocardial infarction (6%) and brain aneurysm (5.0%). The most commonly used antihypertensive medications were renin-angiotensin inhibitors used by 75% of ADPKD patients. Older ADPKD patients and those at ESRD had a significantly higher incidence of cardiovascular events. Conclusion: These findings support the high prevalence of cardiovascular risk factors and events in ADPKD patients which contribute to a greater mortality risk. Due to the prevalence of cardiovascular risk factors in the ADPKD population, early diagnosis and clinical intervention are recommended.
© 2012 S. Karger AG, Basel
Approximately 6 million Americans have chronic cardiovascular and kidney disease combined, resulting in an increasing epidemic of heart and kidney failure [1]. This morbid association represents unique challenges to the clinician. Approximately 600,000 Americans are affected with autosomal dominant polycystic kidney disease (ADPKD), with over 2000 patients starting dialysis every year [2]. Patients with ADPKD have an increased incidence of early onset hypertension, left ventricular hypertrophy (LVH) and cardiovascular abnormalities [3,4]. The reported relative mortality rate in patients with ADPKD ranges between 1.6-fold [95% confidence interval (CI) 1.3–2.0] and 3.2-fold higher (95% CI 2–4.8) in comparison to the general population [5].
Cardiovascular complications are the most common cause of morbidity and mortality in patients with ADPKD [6]. Primary prevention is important to reduce early morbidity and mortality, thus the need for detection and treatment of cardiovascular risk factors in the ADPKD population. There is evidence that blockade of the renin-angiotensin-aldosterone system (RAAS) with better control of blood pressure has improved ADPKD patient and renal survival [7,8,9]. There also are results in hypertensive ADPKD patients which demonstrate that initial therapy with RAAS inhibition compared to diuretics necessitates significantly few antihypertensive medications for comparable control of blood pressure [10].
This study analyzed the cardiovascular events and risk factors in a large number of ADPKD patients according to gender, age, hypertension, cholesterol, smoking and end-stage renal disease (ESRD). This observational study was undertaken in an era in which the majority of patients were receiving RAAS inhibition.
We developed a 6-page survey that was distributed to 1,439 study subjects listed as having ADPKD in our database. The survey asked basic demographic questions and specific questions related to the occurrence of cardiovascular disease in ADPKD patients, including the occurrence of stroke, peripheral arterial disease, abdominal aortic aneurysm, angina pectoris, myocardial infarction, atrial or ventricular arrhythmias, LVH and cardiac valvular abnormalities. The survey also collected information regarding the presence and treatment of cardiovascular risk factors, including hyperlipidemia, smoking, diabetes mellitus, hypertension and medication use (see appendix).
The survey was sent in a single mailing (January 2011) with instructions and an envelope provided in which to return it. A total of 426 (30%) subjects with ADPKD returned the survey completed; of these, 7 were from patients under the age of 18 years and these were excluded from the analysis.
SAS version 9.3 PROC FREQ and PROC MEANS were used to obtain descriptive statistics for the surveys. The difference between the distribution of age categories for men and women was tested using a contingency table χ2 test. p < 0.05 was considered significant.
Proportions for demographics were calculated as a percentage of all respondents.Proportions for other tables were calculated as a percentage of those who responded to that question.
Because multiple outcomes were tested, p values were adjusted using the Bonferroni method. Adjusted p values less than 0.0036 (0.05/14) or unadjusted p values <0.05 were considered significant. This adjustment corrects for the probability of getting a significant p value purely by chance.
ADPKD patients who responded were female (63.2%), nonHispanic (88.1%) and white (93.6%) (table 1). The mean age of the total group was 53.2 ± 13.7 years; 82.8% had a family history of ADPKD and 32.5% had reached ESRD. Analysis of cardiovascular risk factors (table 2) demonstrated that 86.6% had hypertension with a mean age of diagnosis of 36.9 ± 12.9 years with a significantly higher prevalence in males. In addition, 19.6% were obese, 20.8% were smokers, 8.7% had diabetes, 45.7% had high cholesterol and 17.8% were sedentary. The most prevalent self-reported cardiovascular events (table 3) were arrhythmias (25.9%) with a mean age of diagnosis of 43.3 ± 16.4 years, evidence of peripheral vascular disease (16.5%; mean age of diagnosis 45 ± 13 years), heart valve problems (14.4%; mean age of diagnosis 41.2 ± 16.5 years), cardiac enlargement (9.5%; mean age of diagnosis 42.6 ± 13.9 years), stroke or cerebral bleeding (7.5%; mean age of diagnosis 50.8 ± 13.4 years), myocardial infarction (6%; mean age of diagnosis 53.4 ± 9.6 years) and brain aneurysm (5.0%; mean age of diagnosis 43.4 ± 13.7 years). Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) were used in 75% of hypertensive ADPKD patients (table 4). Statins and antiplatelet medications (aspirin) were used in 11 and 22.5%, respectively.
Demographic parameters or cardiovascular risk factors were not significantly different between males and females (table 5). The occurrence of reported heart attacks was significantly higher in males (11.4%) than females (3.1%) (adjusted p value of 0.0136) (table 4).
ADPKD respondents over the age of 45 years were significantly more likely to report hypertension and high cholesterol than those 45 years or younger (table 6). Cardiovascular events were higher in older ADPKD respondents but did not reach significance (table 6).
ADPKD respondents with ESRD were significantly more likely to report diabetes, hypertension and high cholesterol levels (table 7). They also reported a significantly higher incidence of stroke or cerebral bleeding, heart attack and cardiac enlargement (table 7).
The most common extra-renal complications that contribute to morbidity and mortality in ADPKD patients are of a cardiovascular nature [4]. Hypertension is the most frequent cardiovascular complication and contributes to both an increased incidence of cardiovascular mortality and a faster progression to ESRD [6,11,12]. Hypertension develops early in the course of ADPKD [13] and occurs in 50–70% of ADPKD patients with normal kidney function [14,15]. We previously reported a median age at diagnosis for hypertension in ADPKD of 32 years in males and 34 years in females [16]. The current results support the presence of early hypertension in ADPKD. Hypertension is a widespread feature of this disease and has been reported in up to 80% of ADPKD patients with ESRD on dialysis [17]. Thus, the main and most effective therapy in ADPKD remains control of hypertension primarily by including RAAS inhibition [7,8]. For the definitive answer of whether treatment with either ACEIs and/or ARBs results in a decreased rate of renal disease progression in ADPKD, we await the results of the HALT-PKD (Halt Progression of PKD) study [18]. However, the control of hypertension in ADPKD patients is important as it is a specific risk factor for intracerebral hemorrhage and aneurysm ruptures [19].
Our study demonstrates a high prevalence of cardiovascular risk factors including hypertension, obesity, diabetes and hypercholesterolemia in an ADPKD population. In a previous study, 22% of ADPKD patients (age 35.9 ± 11.1 years) with normal kidney function also fulfilled the International Diabetes Federation criteria of metabolic syndrome [20].
LVH is a significant risk factor for cardiovascular morbidity and mortality and a common finding in hypertensive and even normotensive ADPKD patients [21,22,23,24]. However, a recent study in ADPKD patients with preserved renal function reported a prevalence of LVH of 3.9% [25]. Increased LV mass index does occur in children and young adults with ADPKD [13,26,27,28]. The early onset of hypertension in ADPKD may be associated with LVH in nearly 50% of ADPKD patients by their 40s [22].Increased LV mass index has been found to be associated with poor renal and overall outcomes in ADPKD patients [12], and a significant correlation between hypertension and increased LV mass index has been demonstrated in both children and adult patients [13,26,27,28]. RAAS inhibition in hypertensive ADPKD patients has led to the long-term reversal of LVH [29,30]. This finding was significantly greater in association with a rigorous control of blood pressure (<120/80 mm Hg) in ADPKD patients [30].
Structural cardiac abnormalities are found more often in ADPKD patients than in non-ADPKD family members or in normal controls [31]. A prospective echocardiographic study in ADPKD subjects found mitral valve prolapse in 26% and mitral regurgitation in 31% [27]. Tricuspid regurgitation and aortic regurgitation were also found, in 15% and 8%, respectively [29]. In our study, overall heart valve problems were found in 14.4% of patients.
The occurrence rate of coronary events, such as angina, myocardial infarction, and the need for coronary revascularization in ADPKD patients with normal renal function has not been previously reported in the literature. Our survey reported that 3.3% of respondents had angina, 6% had suffered a heart attack and 5.9% had undergone angioplasty, angioplasty and stent or cardiac valve surgery. The mean age for heart surgery was 50.7 ±11.9 years. ADPKD patients with ESRD had less coronary events than matched ESRD patients of other causes [32,33]. This has been attributed to less severe anemia in ADPKD patients [32,33], which is probably due to increased endogenous erythropoietin production [34].
Arterial aneurysms, particularly intracranial aneurysms, are more prevalent in ADPKD patients than in the general population (4.0–11.7 vs. 1.0%) [35,36]. Moreover, it has been suggested that ADPKD is a risk factor for coronary artery aneurysms [37]. Abdominal aortic aneurysm also appears to be more prevalent in ADPKD patients [38,39,40], although in our cohort, the incidence was actually very low (0.8%). However, a tendency towards larger aortic diameters in ADPKD patients compared to a control population has previously been reported [39].
The other major vascular abnormality in ADPKD is intracranial aneurysms (ICA). The prevalence ranges from 5% in patients with no family history of ICA to 21% in those with a positive family history of ICA rupture [32,35,41]. The prevalence may be even higher in ADPKD patients on dialysis, as observed in our study. An occurrence rate of both asymptomatic and ruptured ICA of 33.3% has been reported in ADPKD patients with ESRD [42]. Another study [43] found no difference in incidence of cerebrovascular accidents between ADPKD patients on dialysis and a non-PKD dialysis patient population. Only 25–50% of cerebrovascular accidents in ADPKD patients have been reported to result from ICA rupture [6,44]. In our cohort, brain aneurysm and stroke prevalence or intracerebral bleeding were 5 and 7.5%, respectively. ICA rupture accounts for a 35–55% risk of combined morbidity and mortality [19,45], so identification and screening of patients at risk for developing symptomatic ICA are recommended. Systematic screening of ICA with 3-dimensional magnetic resonance angiography (MRA) is recommended for ADPKD patients, particularly for adults (≥30 years), with a positive family history of hemorrhagic stroke or ICA, those undergoing major surgery with potential hemodynamic instability and those with high-risk occupations [46,47]. It has been recommended that MRA be conducted every 5 years if initially negative and every 2–3 years if positive [46]. However, recent data support a requirement for less screening for ICAs in ADPKD patients and therefore widespread screening is not indicated [48].
Patients with non-PKD chronic kidney disease demonstrate significantly increased cardiovascular events and risk factors [49]. However, ADPKD is unique, due to the early occurrence of hypertension, heart valve problems and ICA. As expected, older ADPKD patients and those with ESRD are at a higher risk for cardiovascular events; male gender, however, may be losing its importance as a risk factor. The early and effective treatment of hypertension in ADPKD is critical for the prevention of cardiovascular events in ADPKD.
There are intrinsic limitations to the survey-based nature of this study and the reported frequencies may be underestimated. Nevertheless, these findings confirm the high prevalence of cardiovascular risk factors and events in ADPKD patients which are associated with an increased risk for mortality. Moreover, older ADPKD subjects and those with ESRD had an increased risk for cardiovascular events, and this increased morbidity and mortality. Due to the prevalence and early onset of cardiovascular risk factors in the ADPKD population, early diagnosis and intervention by aggressively treating blood pressure in ADPKD patients is considered important for the prevention of LVH, cardiovascular complications and mortality.
I.H. received an International Society of Nephrology-funded fellowship and support from the Laboratory of Kidney Pathology (LR00SP01-Pr Ben Maiz Hedi), Charles Nicolle Hospital, Tunis, Tunisia.
P.M. was supported in part by NIH/NCRR Colorado CTSI, Grant No. UL1 RR025780.
The research was supported by grant Nos. M01RR00051, M01RR00069 General Research Centers Program, National Center for Research Resources (NCRR)/NIH, DK34039 from NIH(NIDDK) and by the Zell Family Foundation. The content of this publication are the authors sole responsibility and do not necessarily represent the official NIH views.
Please mark answers with an X or fill in the information in the box as indicated.
By returning this form, I indicate my consent to participate in this survey.
Information will be kept strictly confidential.
Feel free to attach a sheet of paper if needed to clarify an answer.
Robert W. Schrier
University of Colorado Denver, Division of Renal Diseases and Hypertension
Box C-281, 1270 East 19th, RC2 7th floor, Room 7001
Aurora, CO 80045 (USA)
E-Mail firstname.lastname@example.com
Received: July 11, 2012
Accepted: September 10, 2012
Published online: October 04, 2012
Issue release date: October 2012
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 7
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: http://www.karger.com/AJN
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


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Kimberly Kunkel started to work with the ABTA as a means to help others who have been affected by a brain tumor diagnosis. She was diagnosed with a brain tumor herself in 1993, so having the platform to share the impact of brain tumors on patients and their families has been a fulfilling opportunity. Kimberly's background as a Registered Nurse Case Manager helps her connect with members of the brain tumor community both personally and professionally. She believes it is important to keep the faith and allow others to help in any way they are able to in order to have a successful recovery.
Kimberly is a mentor in our CommYOUnity™ Connect program where she is able to provide a listening ear to others who have faced a similar story of having a brain tumor and potentially undergoing surgery. In addition to being an ABTA mentor, she was part of the inaugural group of Social Ambassadors and has contributed to our health care provider outreach efforts. She also made the trip from Ohio to Louisville, KY to serve as a patient panelist at our Partners in Treatment and Care meeting of 2016.


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Lot 348: A rare and early Mills of Sunderland patent aluminium head driver fill
Sporting Memorabilia
by Graham Budd Auctions
November 7, 2016
London, United KingdomLive Auction
Past Lot
Looking for the realized and estimated price?
Description: A rare and early Mills of Sunderland patent aluminium head driver filled from the front with hardwood circa 1900, hickory shaft, a crack in the neck; together with a Jack White driver with Palakona cane shaft, in reasonable condition (2)
Notes: Golf
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Deals on products Chloé Floyd likes
My Lists
My Likes
Win my heart dress
Why buy when you can hire? You'll be the belle of the ball in the Win my heart dress by Jovani. It's embellished detailing mixed with the ruffled hem make this dress extra flirty. A clutch and heels would be ideal accessories. Hire for proms, cocktail parties or a night out. Hire this for your special occasion.
by WISH WANT WEAR


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Free personalized radio that
plays the music you love
Franklyn Ajaye
Selected Discography
Track List: I'm A Comedian, Seriously
Track List: Comedian
Track List: Don't Smoke Dope, Fry Your Hair
Track List: Vagabond Jazz & The Abstract Truth
Track List: Comedy Tonight
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