text:
I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
|Preis ($)
Mesitylene is used to make plastics and dyes. It acts as a solvent, ligand in organometallic chemistry and precursor to 2,4,6-trimethylaniline. It is also used as a developer for photopatternable silicones due to its solvent properties in the electronics industry. It is used as an internal standard in nuclear magnetic resonance (NMR) samples due to the presence of three equivalent protons in it. It is involved in the production of trimesic acid and antioxygen, epoxy firming agent and polyester resin stabilizers. Further, it is used as an additive and component in aviation gasoline blends.
The Adams modification of the Gattermann reaction for aromatic formylation by reaction with Zinc cyanide, L15836 , and HCl is exemplified: Org. Synth. Coll., 3, 549 (1955). The Vilsmeier formylation (see N,N-Dimethylformamide, A13547 ), has been extended to less activated substrates, including mesitylene, by use of the combination of DMF and triflic anhydride: J. Chem. Soc., Chem. Commun., 1571 (1990).
For conversion to mesitoic acid by Friedel-Crafts reaction with oxalyl chloride, and aqueous work-up, see: Org. Synth. Coll., 5, 706 (1973).
Singh, P. Synthesis of mesitylene-based polyamine dendrimer for functionalisation of single-walled carbon nanotubes. J. Exp. Nanosci. 2015, 10 (6), 429-437.
Medina, D. D.; Rotter, J. M.; Hu, Y.; Dogru, M.; Werner, V.; Auras, F.; Markiewicz, J. T.; Knochel, P.; Bein, T. Room Temperature Synthesis of Covalent-Organic Framework Films through Vapor-Assisted Conversion. J. Am. Chem. Soc. 2015, 137 (3), 1016-1019.
Gefahrenhinweise (EU): H226-H335-H411
Flammable liquid and vapour. May cause respiratory irritation. Toxic to aquatic life with long lasting effects.
Sicherheitshinweise: P210-P261-P273-P280-P240-P241-P303+P361+P353-P304+P340-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.


text:
Quality Inn & Suites
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Suites
- Free High-Speed Internet
- Continental Breakfast
- Swimming pool
- Restaurant
- Fitness/Health center
Travelers also looked at:
- More recommendations
- Swimming pool
- Restaurant
- Fitness/Health center
- Free High-Speed Internet
- Wheelchair accessibility
- Free parking
- Suites
- Continental Breakfast
TripAdvisor Reviews Quality Inn & Suites Cincinnati
Travel Blogs from Cincinnati
Last Great Day/Eighth Day
... chocolate and regular cookies, and chocolate brownies. I had one of each. Afterward, I talked with Evelyn, who was on the prayer list some time in the past year or so, but who is doing a lot better now. I had not known that she had spent some time in England, touring and generally having a good time, some years back.
The Last Great Day was busy! We ate from the breakfast buffet that was included in our room charge, then we wanted to ...
Spiritual Food, Fellowship, & Fun
This Feast has been full of great messages, fellowship, and fun with our Church family besides our physical family. I thoroughly enjoyed and benefited from President Kubik's webcast sermon yesterday afternoon. Kind of sobering, too, knowing how much there is to work on to be ready to be the Bride of Christ. I had never before realized how closely Psalm 15 and the Sermon on the Mount tie together. We also had a very helpful seminar ...
Days Three and Four of The Feast
... that they were created at the same time as all the other animals. It was a great way to spend a rainy day, anyway.
Today being Family Day, the children's choir got to sing. I enjoyed helping out with this, and they did a great job. They are always so cute! There were only six children participating, but the children got more individualized attention that way.
We also had a wonderful Family Day event in the meeting hall, which had ...
A Wonderful First Holy Day
... other people, as we had been at our own table for breakfast, and we did, this time. Two of the brethren were the choir director, George Rusnik and his wife Robin. He is such an interesting and friendly guy. The meal we had was wonderful: green beans, mashed potatoes, beef & chicken, bread roll, & best of all, a delicious slice of cake witha lemony filling. We fellowshipped for a long time, and I also met a guy fromToronto, Tony deSanto, who was in ...
Back in London?
... to hit the road again for their various Feast destinations. Mr. Chris Rowland gave an excellent sermon about how to relate to others, and just what it really meant when Peter wrote to be ready with an answer for the hope that lies within us. It doesn't we have to memorize huge long passages of scripture to be a good witness, although I think it helps to know Bible verses, but if we are personally convicted and excited about God's way, we will find ...

subset: commoncrawl


text:
Moment Camera
by Sangho Lee
Universal App – Optimized for iPhone and iPad.>
App Store Description
Moment Camera — Timer/Sequential Shooting
Just a Simple Photo Shooter
The precious Moment of you and me.
Using self-timer and sequential shooting function, never lose the moment you want to remember.
"Moment Camera: A Better iOS Camera App Without the Crap" — GIZMODO: App of the day & iPhone apps of the week
"Moment Camera — The Simpler Camera App Alternative" — Beautiful Pixels
"Moment Camera For iPhone Is A Charming Alternative Snapper With A Beautiful And Clean User Interface" — Redmond Pie
"The iPhoneographer's toolkit: 9 essential iOS apps for shooting, editing and sharing" — The Next Web
"セルフタイマーと連写が魅力のシンプルアプリ『モーメントカメラ』" — Lifehacker
∙ Flash ( Off, On, Auto, Flashlight )
∙ Sequential Shots ( 1, 3, 4, 5, 8, 10 )
∙ Self-Timer ( 0, 3, 5, 10, 30, 60s )
∙ Grid ( None, 3×3, 2×2, Square, Circular )
Self-Timer & Sequential Shooting
∙ Self-Timer: 3, 5, 10, 30, 60 seconds
∙ Timer Sound Effect and Flash Blinking Sign (switch in options, default OFF)
∙ Sequential Shooting: 3, 4, 5, 8, 10 times
∙ Sequential Shooting Intervals: 0, 0.5, 1 seconds (switch in options, Default 0.5)
∙ Sequential Shooting with Self-Timer Function
Concise interface & Convenient functions
∙ Clean and Modern White UI Design
∙ Various Grids: 3×3, 2×2, square, circle
∙ Flashlight Mode Function (Night shooting)
∙ Can Replay(preview) the photos just took (delete in options)
∙ Automatically Saving to Camera Rolls
∙ Touch-focus and Auto-focus
∙ Auto Hide button Function (switch in options, default OFF): When immersed in taking picture, top buttons are hidden automatically. Touch the top or manual focus, the button appears again.
Please allow Camera Roll Access
1. Open Settings
2. Tab Privacy
3. Tap Photos
4. Set "Moment" to On
Moment Camera
∙ Website: http://momentcamera.me
∙ Facebook: facebook.com/momentcamera
∙ Twitter: @MomentCameraApp
∙ URL Scheme: momentcamera://
daramghaus — Studio like a sweet home
∙ Website: http://daramghaus.com
∙ E-mail: email@example.com
∙ Facebook: facebook.com/daramghaus
∙ Twitter: @daramghaus
© daramghaus
What's new in version 1.8
- Fix Geotag bug
Moment Camera is a universal iOS app available in the App Store for $0.99 (Ads free) with no in-app purchases. The app is compatible with all devices running iOS 6.0 or later, including the new iPhone 6 and iPad Mini. To download the Moment Camera app click the button below to go to the app's download page.
If you've enjoyed using the app, please rate and review it on the App store and in the comments section below.
iPhone Screenshots
Recent Reviews
Great!. Excellent!
Perfect but limited.. I thought I had found the perfect delayed shutter app, but I was so disappointed to find that the sequential delay is limited to
only one second.I would give it 5 stars if the delay between shots coul
Simple Burst Camera - Nice!. Great for group photos. I set my camera up for 4 shots, with a 0.5 second gap between each. Later, I pick the best one. The
camera also features an optional auto-flash and optional countdown timer -
Excellent photo app. Small, simple and fast! Exactly what i wanted. Thank you!
Needs something. It would be great if u had a zoom. Unless u do and I can't figure it out, sorry. Lol. But the pinch and zoom in, zoom out would be
great. Thanx for listening.
Share This App
Download Moment Camera App Latest Version on Android and iOS. You can get it directly on your device or download the app to your PC or Mac computer then install the app on your tablet or smart phone.
Similar Apps
17 Your Lifes Moments
Moments Get the photos you didnt take
Heirloom For all the moments we love
Little Moments by Fat Mum Slim


text:
The Zagat Review
"A favorite" for brunch, this "Lowcountry gem" slings "creative" Southern "comfort dishes" in a "cute" Cannonborough/Elliotborough space with a "small-town feel"; while some sniff it's "touristy", more are willing "to wait in line" for the "phenomenal shrimp and grits", "amazing" Charleston Nasty biscuit sandwich and other "reasonably priced", "down-home" eats.
Zagat reviews are compiled from individual user reviews. Write your review.Write your review.
Hominy Grill
207 Rutledge Avenue
Charleston, South Carolina 29403
207 Rutledge Avenue | Map
Charleston, South Carolina 29403


text:
a quotable from Lamont Cranston:
"WHAT EVIL LURKS? ...IN THE HEART OF" ...ah ferget it! :)
To: our dear hosta-lovers-ALL, everywhere!!! ...might anyone here, know
exactly & fer sure and/or even have some ideas as to:
===>>> WHY it is the AHS Executive Board? ..is pushing for an AHS POLICY on
"hosta-registration & preferred grower status"? ..and particularly, with
the following considerations in mind:
(1).. what benefit will result ...from the "registration" of an
un-registered hosta?
(2).. what benefit will preferred-grower status bring?
(3).. how will such a preferred-registration-policy be beneficial
to the AHS rank & file membership and/or the AHS itself?
(4).. how will the exclusion of unregistered-hostas, from
participation at AHS orientated meetings, functions, conventions and
publications: be a benefit to all; and this, also includes our Hosta
Societies, directly affiliated with/to the AHS and including the rank &
file membership of same?
If there is anyone here reading this, whom might like to provide rationale
to the above [PRO?] and/or [CON?]...please do clue us in? ...thanks in
remaining hosta sincerely yours
---< evermore >---
email: "William Nash" <email@example.com>
Personal Website URL = http://www3.sympatico.ca/raffi/
Iril Kolle's Norway Seed Bank =
TO JOIN group list-server = http://www.onelist.com/subscribe/nise
TO JOIN hosta picture group list-server =
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE HOSTA-OPEN


text:
Free personalized radio that
plays the music you love
Lea Salonga (Children's)
Selected Discography
Track List: Now That's What I Call Disney
Track List: Disney Princess: Fairy Tale Songs
Track List: Various Artists: Disney Princess: The Ultimate Song Collection
Similar Artists
I love you so much tarry Rangel you are the best
RhhkcFUSOier s q e b f W e
I like it but 2much adds
Don't have a Pandora account? Sign up
Already have a Pandora account? Log In


text: It's not a B- because they came through in the clutch. They ran the ball pretty well even though they lost their ability to have a sixth OL on the field when Connolly went down, so Marcus Cannon had to play. The OL had lots of protection issues but were good moving bodies off the line of scrimmage. And that late interception, they came back and demonstrated excellent execution in getting the win. Gotta clean up the drops immediately, but great guts late.


text:
Fendi Brown Zucca Vertical Top Handle Bag
You carry yourself well. No wonder that there is always something buzzing in the Fendi world. Whether it be some sort of clothing, accessory, handbag, or even children's styles, Fendi is a staple brand name in the wardrobes of many.
Exterior: Brown and Khaki Zucca Canvas
Interior: Khaki Canvas Lining, One Pocket
Closure: Snap
Hardware: Gold Tone
Handle/Strap: Brown Leather
Additional Items: This item ships with Bella Bag Authenticity Card
SIZE / FITMeasurements: 13" x 4"D x 13"H --4'" Drop
Please note this is previously owned item. As with all previously carried items, there may be some signs of wear
We can ship to virtually any address in the world. Note that there are restrictions on some products, and some products cannot be shipped to international destinations.
When you place an order, we will estimate shipping and delivery dates for you based on the availability of your items and the shipping options you choose. Depending on the shipping provider you choose, shipping date estimates may appear on the shipping quotes page.
Please also note that the shipping rates for many items we sell are weight-based. The weight of any such item can be found on its detail page. To reflect the policies of the shipping companies we use, all weights will be rounded up to the next full pound.
Returns Policy
- Merchandise must be returned within 30 days of receipt, unworn, unwashed and must have all tags attached.
- Please include your order # and how you want to handle the return (Store Credit or Refund) on the attached order return form.
- Please allow 7-10 business days for your return to be processed once your return is delivered.
- All footwear returns must include the original shoebox in its original condition, without postal labels.
- Unfortunately at this time we don't provide return labels. It is the customers obligation to pay shipping costs to WantMyLook returns department.
- Need to make an exchange? Due to always changing availability, we do not offer product exchanges. If you would like to make an exchange, you can return your product and be issued store credit via online gift card to purchase your replacement item.
- Hair accessories, hats, opened makeup, jewelry (earrings, ear cuffs, etc.), underwear, swim wear and bodysuits cannot be returned.
- Any merchandise marked "Final Sale" cannot be returned.
- All sales merchandise (orders using discount codes included) is final sale and can only be returned for store credit.
Returns for store credit will be processed free of charge, while returns for a refund to your original payment method (i.e. credit card, Paypal) will require a handling & processing fee of $3.99 per item, which will be deducted from the amount to be refunded to you. Original shipping charges are non-refundable.


text:
Sunglasses Brands - MensProboardshop.com is the leading eyewear company on the web for Men's Sunglasses, All Brands. All eyewear brands in stock for next day shipment with up to 50% savings. 29 years of great prices, selection, and service.
Please refine here More in the Outlet Shop.
- Brand: Electric
- Price: 40.00 - 59.99
Sunglasses Brands More in the Outlet Shop.
Electric Back Line SunglassesReg: $110.00 On Sale: $40.95
Electric Flip Side SunglassesReg: $110.00 On Sale: $59.95
Electric G-Six SunglassesReg: $89.95 On Sale: $59.95
Electric Hoy Inc SunglassesReg: $90.00 On Sale: $59.95


text:
Want to renew your focus on Jesus during Lent? Sign up for our free Lent & Easter devotions.
34:1 Gilead as far as Dan. The descriptions here and in v. 2 name the areas in terms of the tribal areas as designated in the Book of Joshua (Josh. 13–19).
Starting your free trial of Bible Gateway Plus is easy. You're already logged in with your Bible Gateway account. The next step is to enter your payment information. Your credit card won't be charged until the trial period is over. You can cancel anytime during the trial period.
Click the button below to continue.
You've already claimed your free trial of Bible Gateway Plus. To subscribe at our regular subscription rate of $3.99/month, click the button below.
It looks like you're already subscribed to Bible Gateway Plus! To manage your subscription, visit your Bible Gateway account settings.
Try Bible Gateway Plus, a brand-new service that lets you experience Bible Gateway free of banner ads! It also gives you instant access to over 40 Bible study and inspirational devotional books, including the NIV Study Bible. With Bible Gateway Plus, you can experience and understand God's Word in life-changing new ways, without the distraction of ads. Try it free for 30 days—you can cancel at any time. Following your 30-day free trial, Bible Gateway Plus is only $3.99/month.
Three easy steps to start your free trial subscription to Bible Gateway Plus.


text:
14 servings (serving size: 1 biscuit)
+ Add To Shopping List
1 package dry yeast (about 2 1/4 teaspoons)
1/4 cup warm water (100° to 110°)
2 1/2 cups all-purpose flour
2 tablespoons sugar
1 teaspoon salt
1/2 teaspoon baking powder
1/2 teaspoon baking soda
1/4 cup chilled butter, cut into small pieces
1 cup low-fat buttermilk (1%)
Butter-flavored cooking spra
Prep: 13 Minutes
Cook: 14 Minutes
Chill: 2 Hours
Dissolve yeast in warm water in a small bowl; let stand 5 minutes.
Lightly spoon flour into dry measuring cups; level with a knife. Combine flour, sugar, salt, baking powder, and baking soda in a large bowl. Cut in butter with a pastry blender or 2 knives until mixture resembles coarse meal. Add yeast mixture and buttermilk; stir just until moist. Cover and chill at least 2 hours or overnight.
Preheat oven to 450°.
Turn dough out onto a floured surface; knead lightly 6 times. Roll dough out to 1/2-inch thickness; cut with a 2 1/2-inch biscuit cutter. Place on a baking sheet coated with cooking spray. Spray tops lightly with cooking spray. Bake at 450° for 14 minutes or until golden.
Created date
March 2010
Nutritional Information
Fat 3.7 g
Satfat 2.2 g
Carbohydrate 20.0 g
Cholesterol 10 mg
Iron 1.2 mg
Sodium 248 mg
Calories 127
Protein 3.2 g
Caloriesfromfat 26 %
Fiber 0.7 g
Calcium 34 mg


text:
Is Raffles Hospital Properties incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
Are these details correct?
Is Raffles Hospital Properties in 585 North Bridge Rd Raffles Hospital, Singapore your business? Claim your listing and attract more leads by adding more content, photos and other business details.
Small Business Hub
Sharing tips, ideas and advice to help grow your small business.
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
Hotfrog Small Business Hub


text:
Even as he took his first steps in the race to become London mayor, a figure from his past was preparing to deal his aspirations a fatal blow.
Ted Francis, a former friend who had provided Lord Archer with a crucial alibi in the Daily Star libel trial, was already consulting the PR guru Max Clifford on how to handle fresh and destructive allegations.
Mr Francis, a writer and actor, is said to have acted in protest at the prospect of Lord Archer becoming mayor. He managed to gain pounds 15,000 in the process.
Lord Archer learnt of the scoop on Friday when he had an unexpected visit from the editor of the News of the World, Phil Hall. They spoke for 20 minutes at his penthouse in London, during which Mr Hall revealed the contents of the story it would run. Mr Hall played a recorded conversation between Lord Archer and Ted Francis, made two weeks ago.
Eleven hours later it was all over: Lord Archer, faced with further ruinous press coverage, had decided to step down.
Last night his campaign team was denying that the order to quit came from William Hague, despite a ringing condemnation of his behaviour by the Conservative leader. But Nadhim Zahawi, a campaign spokesman, was promoting a different version of events, insisting that "no pressure was put to bear on him by William Hague or the party whatsoever".
Recounting the events that led to Lord Archer's withdrawal, Mr Zahawi said Mr Hall's visit to Lord Archer's home had prompted a flurry of meetings and phone calls.
The first was an emergency meeting with his campaign staff. Mr Zahawi said Lord Archer then called William Hague to notify him of the story before travelling to the Houses of Parliament for a pre-arranged lunch. It was between 3pm and 8pm that he made his decision to stand down, said Mr Zahawi.
During these hours Lord Archer also phoned the public relations expert Lord Bell and lawyer Lord Mishcon to discuss his position.
Mr Zahawi said throughout the day Lord Archer had been in constant contact with his wife Mary and family, who supported him in his decision.
"I think Mary was very supportive and was happy to support him in whatever decision he made. It was his decision."
But mystery still surrounds the woman with whom Lord Archer dined on that evening 13 years ago. Mr Zahawi refused to comment on her status or occupation and was reluctant to say whether the peer was in contact with her.
- More about:
- Consultancy
- Jeffrey Archer
- Max Clifford
- News Of The World


text:
Matching: request-for-enhancement X
- Sort by:
- Date ▼
- Title
- Likes/Votes
- Comments
- Views
The new Request For Enhancement Community
CalvinPowers Tags: log4j rfe esso single-sign-on websphere-message-broker operational-decision-mana... odm request-for-enhancement sso 6,681 Views
David Robinson discusses what's new in the Request For Enhancement Community . With Release 12, the RFE Community provides new features that keep you up to date on the requests for enhancement (RFE) you're watching and are...
from Blog: This Week on developerWorks WebcastModified on by CalvinPowers
IBM Software RFE Community, Release 11!
kellypuffs Tags: rfe rfe-community request-for-enhancement ibm 3,152 Views
We are pleased to announce that the IBM Software RFE Community was recently updated, and Release 11 is now live and in production. During the successful deployment of this release, more than 282 RFEs and defects were addressed,...
from Blog: Notes from Rational Support


text:
Playing It UNsafe
American Composers Orchestra & Jeffrey Milarsky
Open iTunes to preview, buy, and download music.
|10 Songs
Formed: 1977
Genre: Classical
Years Active: '70s, '80s, '90s, '00s
Specializing in performing symphonic works strictly by American composers, the American Composers Orchestra was originally conceived in 1975 by composer Francis Thorne and conductor Dennis Russell Davies. Realizing that the majority of American-based orchestras failed to play works composed by Americans, the duo set out to correct the problem on their own. With Davies serving as the orchestra's principal conductor and music advisor, composer Nicolas Roussakis and conductor/flutist Paul Lustig Dunkel...Full Bio


text:
With their fun photo print, these trunks from Bjorn Borg will add a little whimsy to your underwear collection. Made from cotton with a hint of elastane for maximum comfort, theyre finished with a branded elasticated waistband.
Thank you for visiting Bjorn Borg Road Trippin Trunks, Multi on shoppingfind.co.uk
We bring the products from many websites to one website for you to search, save and compare.


text:
Shadynasty Tablet
Shadynasty Protect your tablet with an impact resistant hard shell case featuring an extremely slim profile. The lay-flat feature protects the front of your iPad by extending the bezel above the screen. Compatible with the Apple iPad Smart Cover. Great case offering solid protection and direct access to all device features.
Shipping is £3.99 globally on orders less than £30. Shipping is FREE for all orders over £30. Orders are delivered within 5-7 business days. If you have a query about delivery for a product which you have already ordered, please contact us.
If you don't absolutely love it, we'll take it back!
If you're not happy with your order, please contact us as soon as possible. In all cases we'll ask you to provide photographs of the item, including a close up of any tags/labels. To help us respond to you quickly, please include the order number in your message to us.
We have a money-back satisfaction guarantee, so whatever the problem, we're happy to work with you to fix it.
- Tags: afrikaburn, apogaea, australia, blazing-swan, finland, grammy-award, hands-and-knees, larry-harvey, library-of-congress-control-number, lions-gate-entertainment, live-on-sunset, midburn, naturi-naughton, other, parents-just-dont-understand, pink-mammoth, playa-del-fuego, playas-gon-play, rapping, tony-award, uk-singles-chart, united-states


text:
From Bioblast
|Terms and abbreviations
|Concepts and methods
|High-resolution respirometry
|MiP and biochemistry
Stirrer test
A stirrer test is performed in the O2k for quick evaluation of the performance of the OroboPOS and for dynamic calibration. The stirrer test is initiated by pressing [F9] in DatLab. Stirring is stopped in both chambers and restarted after a selected period (default: 30 s).
Abbreviation: F9
Reference: MiPNet06.03 POS-calibration-SOP
MitoPedia O2k and high-resolution respirometry: DatLab


text:
Southeast Georgia Physician Associates-Glynn General & Vascular Surgery
General Surgery
Vascular Surgery
Brunswick Office:
Office of Drs. Arlauskas, Barrett, Beach, Segerberg & Tsai
2500 Starling Street, Ste. 201 Brunswick, GA 31520
Phone: 912-265-5125
Office Hours:
Monday-Friday, 8:30 a.m.-5 p.m.
Jesup Office:
Office of Dr. Beach:
125 Peachtree Street Jesup, GA 31545
Phone: 912-265-5125
Office Hours:
Monday, 9:30 -11 a.m.
Are you a new patient?
Please bring the following to your first appointment:
- Your insurance card and a picture ID
- Completed registration forms (see below "Related Documents")
- A list of your current prescriptions and/or over-the-counter medications (please include your dose and frequency)
- Pertinent information about your medical and surgical history
- Recent X-rays or other test results related to your condition
If you are unable to complete the registration forms (below) prior to your visit, we request that you arrive at least 30 minutes before your scheduled appointment time to complete the forms in person. However, we respectfully request that you print these forms, fill them out and bring them with you to your first appointment.


text:
Upload Some Contents to Joomla + 6 Products to Virtuemart + 2 Modules
This project was successfully completed by bdweb for $55 USD in 7 days.Get free quotes for a project like this
Project Budget$30 - $250 USD
Completed In7 days
Total Bids13
Project Description
We need a freelancer to upload contents to a Joomla Website + make some small modifications (modules + logo upload, etc.). It is not making a custom template. You will not have to make custom programming. It is just loading contents and small modifications. We will provide… Joomla already installed + administrator + FTP user and pass + the chosen template + source files + quickstart + content and images.
- Logo: the client will send its logo, you will have to upload it and make it fit on the chosen template after editing it and make it look nice or improve it a bit;
- Modules: add 2 or 3 modules (right, or left, or bottom), for example: a link to the client`s Facebook and Twitter pages with an icon + a text with tips or faqs + some banners + google maps + addthis + some contents or similar, etc.;
- Template: a template is already installed and working, you need just to organize the structure to make it look like the client desires (unpublish unnecessary modules, publish others, etc.,);
- Tabs: each tab is a button of the menu you must create. There are 5 tabs to load, for example: Home + About Us + Our Services + Clients + Contact (must include a Google Map), etc.. Each page must contain a text of at least 200 characters and 2 images. The texts and images are provided by the client. If not, you can upload any sample text or image you find on the Internet, always related to the client´s business (most contents will be in Spanish - Español);
- Footer: add a link to our site and a menu;
IMPORTANT: the texts must be in order (justified, with some bolds, typo, nice style, etc.), the images must have text around, a border of 2 pixels, a link to popup, etc. (that means: not just copy and paste). Typography: it is important that ALL the texts of the site have advanced typography, for example… bold, block quotes, notice styles, icons, etc.
Total budget for this job is $ 55,00.- since it is just adding some contents and minimum details (it can be done in a few hours, it is really easy). Please do not bid more than that amount. A plus can be paid if done fast and as indicated. We can send you 50% in advance by Milestone System once you indicate you can start with this. You will start working as soon as possible. The whole Job can be done in less than 1 day, but we can give you 5 or 6 days to finish it correctly.
Please only bid if you have at least more than 5 positive feedbacks (or will not be considered) and have some works to show, of proven experience in Joomla, and you are professional and you are not doing this on your spare time, and you start with this asap.
The freelancer must have experience in working with the following Joomla Frameworks...
Happy Bidding!
Completed by:
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Established 1980, Your Perfect Partner is a most personalized introduction agency, dating service and matchmaker in Sydney. The matchmaking services are conducted by one to one introductions for singles looking for long term relationships, making friends and enlarging social circles. Ongoing personal consultation for each client is an important feature of the successful matchmaking service as well as monthly held singles events. YPP also looks after seniors dating with success since 2004.
The service is a good alternative to online dating. Apart from introductions to existing registered members, YPP provides you with professional technical assistance to maximize your opportunity of finding the right person by utilizing other dating venues and online websites such as RSVP or Match.com. You will efficiently shorten your journey of searching.
YPP is a dedicated dating service which tries to look after clients' personal wellbeing as its ultimate goal;It's not just a telephone number or a piece of photo. The service is affordable; success blossoms on the mutual trust between service and clients.
Our service is personalized and highly professional. We have been successfully matching couples since 1980. You deal directly with Rose, the owner, who has matchmaking experience since 1992 and takes matchmaking as her ultimate interest and passion; and she CARES. .
We provide ongoing support and insightful personal consultation throughout your dating process if you need. Dating with us opens a door towards your brightest future.
Our clientele – Sydney local singles from all cultural backgrounds and all walks of life; Open minded professionals; strong base of Australian Asians and Europeans; We also have good results for active seniors or widowed people.
Our monthly events are tailored and friendly; Rose personally organizes and attends the functions to assist you. You meet a very friendly group of genuine people at our events especially singles over 45 years of age.
Our fees are most competitive. Our service is result driven, not profit driven. The first step is to visit our office and have a friendly meeting with Rose. We shall explain how it works, discuss your needs and requirements and how we shall assist you.


text:
Wall Clock
Night Shift (夜勤)by Dr. Lukas Brezak
Up To $25 Off + Free Shipping on All Wall Art - Ends Tonight at Midnight PT!
Available in natural wood, black or white frames, our 10" diameter unique Wall Clocks feature a high-impact plexiglass crystal face and a backside hook for easy hanging. Choose black or white hands to match your wall clock frame and art design choice. Clock sits 1.75" deep and requires 1 AA battery (not included).
Well... I cannot tell you the story behind this, because it is scary as hell! --- Screaaaaaam!!! --- And it is true story!... :OOOO


text:
Greg Osby
Alto saxophonist Greg Osby is a legitimate rarity in jazz: a major-label artist who makes challenging music.
Public was cut live at New York's Jazz Standard during two nights in January, but it's no throwaway souvenir. Despite the club setting, the sonics are superb, and the playing by Osby and a gifted gaggle of accompanists, including trumpeter Nicholas Payton and drummer Rodney Green, is thrillingly spontaneous yet surprisingly accessible. Osby originals such as "Rising Sign" and "Visitation" remain true to the music's traditions without feeling hemmed in by them. Likewise, the combo's allergy to predictability helps warhorse standards such as "Summertime" wind up in the winners' circle.
Even seeming missteps manage to stay on track, including a version of "Lover Man" featuring vocals by current Dead associate Joan Osborne. At the conclusion of the tune, which works better than anyone has a right to expect, Osborne says, "It's a real privilege to be here." Listeners are apt to feel the same.
Greg Osby
Get the Music Newsletter
Keep your thumb on the local music scene each week with music news, trends, artist interviews and concert listings. We'll also send you special ticket offers and music deals.
In Case You Missed It
Upcoming Events
Bandwagon Magazine Battle of the Bands - Final Round
TicketsFri., Mar. 3, 7:00pm
DJ Ktone 10th Anniversary Bday Bash
TicketsSat., Mar. 4, 8:00pm
UNC Jazz Thang
TicketsMon., Mar. 6, 7:30pm
Chris Trapper
TicketsThu., Mar. 2, 8:00pmpowered by goldstar
Sponsor Content


text: 7 photos $2,500,000 41 acres 3 Beds | 4 Baths | 4695 sqft 20636 Chippewa Cree Lane, Herman, NE 68029 - Washington County Missouri River home Your own private escape! The Pointe House sits on secluded peninsula with approx 1,200 ft of river frontage. Amazing views along with quality construction & features thruout home! Gourmet kitchen opens to living room with soaring 20 ceiling & stunning wall of windows with panoramic views. Luxurious master suite. From the tower, see for miles with 360 views! Property has 41.4 acres, heated shop, 2 addl homes & rural water. Perfect for year round living, private getaway or corporate retreat. Travis Svendgard Your Home Team, LLC


text:
Posted by Anonymous on Monday, January 13, 2014 at 4:15pm.
This doesn't make any sense.
Our supervisor prepared a that reminded the salespeople of the producer to be followed during the Holliday season
This is the whole question:
Converting Terminology via computers.
A. Cryptography
B. Technology
C. Geometry
D. Geology


text:
Chaifetz Arena Offers Valentine's Day Dinner Packages
Still looking for a great way to celebrate Valentine's Day? The New Jack Swing Valentine's Jam will come to Chaifetz Arena Friday, Feb. 15. The show will feature Dru Hill, Tony! Toni! Tone!, Guy, SWV and Al B Sure.
Chaifetz Arena is offering a special package that includes both a ticket to the show and a dinner before the concert. The details of the package are outlined below:
- Sweetheart Package: $105 per person (includes P1 level ticket, red seats on seating chart, and dinner)
- Cupid Package: $95 per person (includes P2 level ticket, blue seats on seating chart, and dinner)
- Valentine Package: $85 per person (includes P3 level ticket, green seats on seating chart, and dinner)
A seating chart can be found and viewed at the Chaifetz Arena website.
The dinner will be held in our Lorenzini's restaurant, which is located in the Arena. Dinner will be at 6:30 p.m. and the concert will begin at 8 p.m.
The menu will include:
- Mixed garden greens with tomatoes, cucumbers and red onions and choice of ranch and Italian dressing
- Yukon gold potato salad
- Cornbread and jalapeno muffins
- BBQ beef brisket
- Herb roasted chipotle chicken
- Lyonnaise potatoes
- Baked beans
- Corn on the cob
- Premium dessert table
- Soft drink and cash bar available
For more information or to order tickets, call Cortney Putters at 314-977-5008. Orders must be in no later than 5 p.m. Wednesday, Feb. 13.


text:
Kaka is leaving ! | AC Milan Transfer News | (28/06/14)
- published: 28 Jun 2014
- views: 1503
Rossoneri TV takes a look at this week\'s news and rumors concerning AC Milan. In this episode, Adamo talks about Kaka leaving Milan and Iturbe\'s advancements. Subscribe, FREE, for more videos: http://bit.ly/RossoneriTV About Rossoneri TV: We are a Youtube Channel that strives to post content for Milan fans. We bring you Match Reviews and Previews before and after every match, breaking news, reactions and more! Follow us on Twitter: https://www.twitter.com/RossoneriTV Like us on Facebook: https://www.facebook.com/RossoneriTV...


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Johnny Kewl" <j...@kewlstuff.co.za>
|Re: Trying to mix db connection pooling on web and desktop applications
|Wed, 23 Jul 2008 07:00:16 GMT
Out of luck ;) Dont think it can be done... I think JNDI has a problem serving dB connection pools outside of a container... it needs the classloaders, common JVM etc etc. I imagine one could make a RMI type provider... but a direct connection to the dB via JDBC is probably always going to be better. ie outside of the container... JNDI is very much DNS/LDAP etc... because they just tcp/ip derivatives, not a recordset on a wire... Maybe other solutions... Find your own dB Pool... there are some good ones out there... You place the biz logic and pool in the JRE EXT extension classloader folder... Your servlet uses it thru the INIT method... Your app can see it... IF its on the same JRE.... (see, thats why JNDI/JDBC becomes an issue outside of the same process...) Then EJB is an option.... biz logic on app server ... ok dont have a heart attack ;) If its just a dB connection.... what about an old fashioned JDBC connection from the app... a single app probably doesnt need a connection pool... // Load the database driver Class.forName( "sun.jdbc.odbc.JdbcOdbcDriver" ) ; // Get a connection to the database Connection conn = DriverManager.getConnection( "jdbc:odbc:Database" ) ; Unless of course that biz logic is holding state... in which case its more than just a dB pool, you trying to share the biz logic... thats more EJB like... For this I would just use the POJO Application server (runs on TC)... thats different again... There you put your biz logic in the PAS and let both Tomcat and the external app use it... its a brand new type of technology (yours truely) Or you put the whole app in the server and it jumps out of browsers... a long story ..... a good old fashioned JDBC connection from the application.... probably the easiest. I dont think JNDI can do it.... ie it cant suck up a recordset thats going to work on the wire, not without RMI and a whole lot of other stuff happening ;) Generic problem is that one cant even assume the application and tomcat are even on the same JRE... same machine is not enuf. Just dont start sharing classes in tomcat libs on the general classpath to try make this work... that will really screw TC up Good luck... nice question... almost the kind of thing one expects to work... at first anyway... =========================== ----- Original Message ----- From: "Alejandro Hernandez Angeles" <firstname.lastname@example.com> To: <firstname.lastname@example.com> Sent: Tuesday, July 22, 2008 9:51 PM Subject: Trying to mix db connection pooling on web and desktop applications Hello, this is the scenario: I have an application that must have two interfaces: as a desktop application and as a web application I've put the business logic inside a JAR library (client_bpm.jar), which must connect to an Oracle 9i database I configured the web application so it can use a db pool connection, in the following manner: And the web application runs fine, i have no problems with it Now, what i want is to use the same db connection pool facility (that Tomcat provides to web applications) on my desktop application, and use the same code (or something very similar) i used in point 6 to obtain a db connection With points 1-3 Tomcat provided my web application with a db connection pooling facility I want Tomcat to provide to my desktop application the same db connection pooling facility, ¿How do i do that? I have tried invoking my desktop application with the following: java -classpath ".;%CATALINA_HOME%/webapps/myWebApp/WEB-INF/lib/client_bpm.jar;%CATALINA_HOME%/lib/catalina.jar;%CATALINA_HOME%/bin/tomcat-juli.jar;%CATALINA_HOME%/lib/ojdbc14.jar" -Djava.naming.factory.initial=org.apache.naming.java.javaURLContextFactory -Djava.naming.factory.url.pkgs=org.apache.naming MyDesktopApp Any suggestions will be appreciated --------------------------------------------------------------------------- HARBOR : http://www.kewlstuff.co.za/index.htm The most powerful application server on earth. The only real POJO Application Server. See it in Action : http://www.kewlstuff.co.za/cd_tut_swf/whatisejb1.htm --------------------------------------------------------------------------- --------------------------------------------------------------------- To start a new topic, e-mail: firstname.lastname@example.com To unsubscribe, e-mail: email@example.com For additional commands, e-mail: firstname.lastname@example.com
|View raw message


text:
Roosevelt University-Graduate Business Programs Information Session
Roosevelt University: Office of Admission
Wednesday, October 19, 2011 from 5:30 PM to 6:30 PM (CDT)
Event Details
The Graduate Business Programs Info Session will provide you the opportunity to meet with faculty, learn about new scholarship opportunities, and gain more information on the many business graduate degrees Roosevelt University offers.
The Heller College of Business offers diverse classes while still maintaining small class sizes that allow the faculty to provide personal attention to each student. With the exception of the real estate program, offered only in Chicago, all of our business programs are available at both our Schaumburg Campus and our Chicago Campus.
In addition to these convenient locations, you will also have the flexibility of taking classes in the daytime, evening, and on Saturdays. Opportunities to learn are vast as all of our faculty members have business experience and we also offer free mentoring as well as tutoring for some of the core MBA courses. Internships are also readily available as there are currently more jobs than students. The GMAT, although recommended, is not required for students with a cumulative undergraduate GPA of 3.0/4.0.
When & Where
Roosevelt University-Gage Building
18 S Michigan Ave
Wednesday, October 19, 2011 from 5:30 PM to 6:30 PM (CDT)
Add to my calendar
Roosevelt University: Office of Admission


text:
Engine trouble may have caused the Turkish Airlines crash that killed nine people in the Netherlands, the head of the agency investigating the accident said yesterday.
Pieter van Vollenhoven said the Boeing 747-800 had fallen almost directly from the sky, which pointed toward the plane's engines having stalled. He said a reason for that had not yet been established.
Sandra Groenendal, of the Dutch Safety Authority, added that stalled engines on the plane were still "one of the possible scenarios" for the crash. Mr van Vollenhoven said analysis of the flight data recorders in Paris could be completed today, but his agency would probably not make a preliminary finding until next week. "We hope to have a firmer grip as soon as possible," he said, adding that the information retrieved was of high quality.
Flight TK1951 from Istanbul crashed about a mile (1.5km) short of the runway at Amsterdam's Schiphol airport on Wednesday morning, smashing into three pieces and spraying luggage and debris across a farmer's field. It was carrying 134 passengers and crew.
Despite the catastrophic impact, the wreckage did not burn and dozens of people walked away with only minor injuries. Emergency services took the injured to nearby hospitals; six were still in critical condition yesterday. Both pilots died.
- More about:
- Air Transport
- Amsterdam
- Baggage And Luggage
- Istanbul


text:
Man arrested in Aliso Viejo after Starbucks robberies
ALISO VIEJO – A man was arrested Sunday morning in connection with two coffee-shop robberies in Laguna Niguel, sheriff's officials said.
Orange County Sheriff's spokesman Lt. Jeff Hallock said Darren Ong, 21, of Laguna Niguel, is accused of first entering the Starbucks store at 30065 Alicia Parkway about 5:37 a.m., handing an employee a note demanding money and claiming he had a gun, then fleeing the store with an unknown amount of cash.
As Ong fled, a witness was able to get his license plate number, deputies said, and it was broadcast to officers.
Deputies said Ong also is suspected of robbing another Starbucks store less than a half-mile from the first incident.
Ong was spotted by deputies outside a Circle K at 24281 Pacific Parkway in Aliso Viejo, about five miles from where the original robbery occurred and taken into custody at gunpoint, deputies said.
Hallock said a search of Ong's car did not turn up a weapon, but that an undisclosed amount of cash was found.
Ong faces robbery charges, Hallock said.
Contact the writer: firstname.lastname@example.com or on
Contact the writer:
Contact the writer: Twitter:@earleyOC
Most Popular
- Mourners gather to remember slain Whittier policeman killed in the line of duty
- Cyclist hurt after crashing into SUV in Newport Beach
- 1 person hurt in crash where 2 cars crash, 1 flips on 57 freeway at 91
- Newport Beach celebrity dentist from TV's 'The Swan' surrenders license
- Lakers have much to address before season ends
User Agreement
Comments are encouraged, but you must follow our Privacy Policy Policy & Terms of Use
Keep it civil and stay on topic. No profanity, vulgarity, racial slurs or personal attacks. People who harass others or joke about tragedies will be blocked. By posting your comment, you agree to allow Orange County Register Communications, Inc. the right to republish your name and comment in additional Register publications without any notification or payment.


text:
Chicken Liver and Onion Kabobs
|Chicken livers
|12 Ounce (8 Large Sized)
|Vegetable oil
|1 Tablespoon
|Canned small white onions
|8 Ounce (1 Can)
|Bacon slices
|2 , cut into 8 small pieces
|Worcestershire sauce
|2 Tablespoon
|Dry wine
|1 Tablespoon
1) Take the chicken livers and cut each piece into half.
2) Devein the veins connecting the liver pieces together and peel off the skin.
3) Use vegetable oil to brush the livers.
4) Take 4 wooden skewers and follow the order: whole onion, chicken liver, whole onion, bacon, chicken liver, whole onion, bacon, chicken liver, whole onion, chicken liver, whole onion to thread each kabob to it.
5) Other 3 skewers may also be arranged in the same way.
6) Take a baking dish and use two folded sheets of paper towels to cover it.
7) Place the kabobs on it.
8) Apply Worcestershire sauce and sprinkle dry wine on top.
9) Use another paper towel to cover.
10) Allow cooking for 10 minutes.
11) Serve hot with sauce.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 155 Calories from Fat 74
% Daily Value*
Total Fat 8 g12.8%
Saturated Fat 2 g9.8%
Trans Fat 0.1 g
Cholesterol 294.3 mg98.1%
Sodium 360.6 mg15%
Total Carbohydrates 4 g1.3%
Dietary Fiber 0.68 g2.7%
Sugars 2 g
Protein 15 g30.2%
Vitamin A 188.5% Vitamin C 31.1%
Calcium 4.1% Iron 45.2%
*Based on a 2000 Calorie diet


text:
Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial
DOI: 10.1186/cc6173
© Jimenez et al.; licensee BioMed Central Ltd. 2007
Received: 17 July 2006
Accepted: 07 November 2007
Published: 07 November 2007
Extracorporeal circulation induces hemostatic alterations that lead to inflammatory response (IR) and postoperative bleeding. Tranexamic acid (TA) reduces fibrinolysis and blood loss after cardiopulmonary bypass (CPB). However, its effects on IR and vasoplegic shock (VS) are not well known and elucidating these effects was the main objective of this study.
A case control study was carried out to determine factors associated with IR after CPB. Patients undergoing elective CPB surgery were randomly assigned to receive 2 g of TA or placebo (0.9% saline) before and after intervention. We performed an intention-to-treat analysis, comparing the incidence of IR and VS. We also analyzed several biological parameters related to inflammation, coagulation, and fibrinolysis systems. We used SPSS version 12.2 for statistical purposes.
In the case control study, 165 patients were studied, 20.6% fulfilled IR criteria, and the use of TA proved to be an independent protective variable (odds ratio 0.38, 95% confidence interval 0.18 to 0.81; P < 0.01). The clinical trial was interrupted. Fifty patients were randomly assigned to receive TA (24) or placebo (26). Incidence of IR was 17% in the TA group versus 42% in the placebo group (P = 0.047). In the TA group, we observed a significant reduction in the incidence of VS (P = 0.003), the use of norepinephrine (P = 0.029), and time on mechanical ventilation (P = 0.018). These patients showed significantly lower D-dimer, plasminogen activator inhibitor 1, and creatine-kinase levels and a trend toward lower levels of soluble tumor necrosis factor receptor and interleukin-6 within the first 24 hours after CPB.
The use of TA attenuates the development of IR and VS after CPB.
Trial registration number
Cardiopulmonary bypass (CPB) may activate an inflammatory response (IR) involving contact system, complement, cytokine, and coagulation-fibrinolytic cascades, among others. The coagulation-fibrinolytic cascades and the IR, though in many respects separate processes, are closely interconnected [1]. Several preoperative and perioperative risk factors for IR have been proposed [2, 3]. The incidence of vasoplegic shock (VS), the most severe presentation of IR, may be as high as 10% [4].
Numerous strategies to reduce IR and bleeding in high-risk patients exist, among which is the use of aprotinin [5]. Like aprotinin, tranexamic acid (TA) inhibits fibrinolysis (that is, plasmin activity and D-dimer formation), but its effect on IR remains unclear. Additionally, there is evidence that fibrinolysis is a marker for the onset of systemic inflammation. [6].
This paper describes a study in two parts. First, we performed a case control study to determine risk factors associated with IR in patients who underwent CPB. Second, we carried out a randomized, double-blind, placebo-controlled study to test the hypothesis that inhibition of excessive fibrinolysis by TA could reduce the incidence of IR and VS after CPB. The second study was interrupted because of the high incidence of adverse effects observed in the placebo group. Thus, we present data of an interim analysis.
Materials and methods
The study was approved by the institutional ethics committee of the University Hospital of the Canary Islands (La Laguna, Spain) and was conducted according to the Declaration of Helsinki. The study consisted of two parts.
Part 1: Assessment of postoperative incidence and protective/risk factors for inflammatory response after cardiopulmonary bypass
After obtaining informed written consent, we prospectively enrolled 191 consecutive Caucasian adult patients scheduled for cardiac surgery with CPB between January 2002 and February 2003. To avoid the effect of confounding factors on the IR, patients with endocarditis and those admitted with cardiogenic shock or with intra-aortic counterpulsation balloon were excluded (n = 26). Finally, a total of 165 patients were included. No patients received perioperative anti-inflammatory agents such as corticosteroids or nonsteroidal anti-inflammatory drugs.
IR was clinically defined as a core body temperature of greater than 38°C (100.4°F) in the first 4 hours after intervention, a systemic vascular resistance index of less than 1,600 dyn-seconds/cm5 per square meter, and a cardiac index of greater than 3.5 L/minute per square meter. VS was defined as persistent hypotension (mean arterial pressure of less than 70 mm Hg) requiring norepinephrine for at least 4 hours after failure to respond to appropriate volume expansion (pulmonary capillary wedge pressure of greater than 15 mm Hg). Serum concentrations of interleukin-6 (IL-6) were measured at 4 hours after CPB (Materials and methods, part 2). Risk factors associated with IR after CPB, including demographic variables, comorbid conditions, preoperative medication, duration of CPB, aortic crossclamp time, and the use of antifibrinolytic drugs, were investigated. Perioperative management of the groups was similar in the two studies (Materials and methods, part 2), except for the study medication. In this study, the surgeon decided when to use TA.
Part 2: Prospective double-blind trial of tranexamic acid effect on inflammatory response after cardiopulmonary bypass
We performed a randomized, double-blind, placebo-controlled study with consecutive Caucasian adult patients undergoing elective CPB surgery from February to May 2004. Postoperative care of the patients was performed in a 24-bed intensive care unit (ICU) at a university hospital. We excluded emergency interventions, patients with a history of chronic coagulopathy (prothrombin time [PT] of less than 50% or international normalized ratio of greater than 2 and platelets of less than 50,000/mm3 or aggregation dysfunction), renal failure (creatinine of greater than 2 mg/dL), chronic hepatopathy (Child B or higher degree), use of immunosuppressant drugs, endocarditis, sepsis in the first 24 hours after intervention, or unwillingness to enroll. Before CPB, participants had normal bleeding time, platelet collagen/epinephrine and collagen/ADP closure time, PT, activated partial thromboplastin time, and thrombin time. None of the patients received anti-inflammatory agents such as corticosteroids or nonsteroidal anti-inflammatory agents, including acetyl salicylate acid or clopidogrel or immunosuppressants, on the previous 5 days and the first 24 hours following intervention.
After informed written consent was obtained, patients were randomly assigned by independent pharmacists using a list of pseudorandomized numbers to receive coded infusions of either TA or placebo (0.9% saline) with doses of 2 g pre-CPB and post-CPB after protamine administration (using the same protocol as in the previous part of the study). The code was revealed once recruitment, data collection, and laboratory analyses were completed. The primary endpoint was to test the effect of TA on the incidence of IR and VS in patients undergoing elective CPB. Secondary endpoints were biological parameters related to inflammation, coagulation, and fibrinolysis systems.
Data collection
Demographic variables, comorbid conditions, perioperative clinical data, and postoperative outcomes (IR, VS, duration of mechanical ventilation, postsurgical ICU stay and hospital stay, and mortality) were recorded. Core body temperature, biochemical determinations (hematology, inflammation, coagulation, and fibrinolysis), and hemodynamic parameters were recorded before intervention (baseline), on admission to the ICU after surgery (0 hours), and at 4 hours and 24 hours after intervention. In addition, blood loss measured by tube chest drainage and the amount of hemoderivatives used, as well as its frequency, were collected after intervention at the above time points and when chest tubes were removed (defined as total bleeding). Surgical risk was calculated by Parsonnet score.
Anesthetic procedures were standardized and consisted of an opioid-based anesthetic supplemented with volatile anesthetic and muscle relaxants. All interventions were performed by the same surgical team with wide experience in these surgical interventions. All patients were preoperatively monitored with a pulmonary artery continuous thermodilution catheter (Edwards Lifesciences LLC, Irvine, CA, USA). Neither heparin-coated circuits nor leukocyte filters were used. The extracorporeal circuit consisted of a hardshell membrane oxygenator (Optima XP; Cobe, Denver, CO, USA, or Quantum Lifestream International, Inc., Woodlands, TX, USA), a Tygon™ (Dideco s.r.l., Mirandola, Italy) extracorporeal circuit, and a Medtronic™ Biopump (Medtronic, Inc., Minneapolis, MN, USA) centrifugal pump. Below hypothermic temperatures of 28°C to 30°C, the pump flow was adjusted to maintain a mean arterial pressure of greater than 60 mm Hg and a flow index of 2.2 L/minute per square meter. Myocardial protection was achieved using antegrade, cold, St. Thomas 4:1 sanguineous cardioplegia. The circuit was primed with 30 mg of heparin followed by an initial dose of 3 mg/kg and further doses when necessary to achieve and maintain an activated clotting time of 480 seconds. To reverse the effect of heparin, protamine was used based on blood heparin levels measured by Hepcon® (Medtronic, Inc.). A blood salvage device was used in all patients. The transfusion trigger was a hemoglobin threshold of less than 8 g/dL, PT of less than 50%, and platelets of less than 50,000/mm3. Fluid management was carried out to achieve 8 to 12 mm Hg of central venous pressure or 12 to 15 mm Hg of pulmonary artery occlusion pressure at zero positive end-expiratory pressure by infusions of crystalloids and colloids. Catecholamine support, when necessary, was used as follows: Norepinephrine was titrated to achieve a mean arterial pressure of greater or equal to 70 mm Hg, and dobutamine was titrated to achieve a cardiac index of greater or equal to2.5 L/minute per square meter. Amines were tapered off in steps of 0.02 and 1 μg/kg per minute, respectively.
Cytokine levels
Soluble tumor necrosis factor receptor (STNFR)-1 and IL-6 (normal range: less than 5.9 pg/mL; intra-assay variation: 4.5%) were measured using an automatic immunoenzyme assay system (IMMULITE ONE™; Diagnostic Products Corporation, now part of Siemens AG, Munich, Germany). STNFR-1 EASIA (normal range: 3.4 to 10.8 ng/mL; intra-assay variation: 1.7%) are solid phase enzyme-amplified sensitivity immunoassays performed on a microtiter plate (, Biosource Technologies, Inc., Fleunes, Belgium).
Coagulation and fibrinolysis determination
Quantitative plasminogen activator inhibitor 1 (PAI-1) antigen (normal range: 2 to 47 ng/mL; intra-assay variation: 3.7%) and tissue plasminogen activator antigen levels (normal range: less than 9.0 ng/mL; intra-assay variation: 4.2%) were measured using an enzyme-linked immunosorbent assay (IMUBIND®; American Diagnostica Inc., Stamford, CT, USA). D-dimer (normal range: less than 300 ng/mL; intra-assay variation: 3%) was measured using an immunoturbidimetric test (D-dimer PLUS; Dade Behring, now part of Siemens AG).
Statistical analysis
Comparisons between groups (patients with and without IR or the TA group versus placebo group) were performed using the Pearson χ2 test or Fisher exact test for categorical variables and the Student t test or the Mann-Whitney U test for continuous variables, as appropriate. Logistic regression analysis (forward stepwise conditional) was used to identify independent risk factors associated with IR. Initially, only variables with a P value of less than 0.15 (TA, clamping time, and mixed cardiac surgery) in the univariate analysis were incorporated. To perform the controlled study, a sample size of 100 patients was required to detect a statistically significant reduction of at least 20% in IR by TA. Assuming an incidence of 30% in the placebo group, a study population of 100 patients was expected to have 80% power to detect a 20% reduction in IR. For primary endpoint outcomes, all differences in preoperative variables with a P value of less than 0.15 in the univariate analysis of the controlled study were entered into a logistic regression analysis. Results for qualitative variables are expressed as frequency and percentage. Quantitative variables are expressed as mean ± standard deviation or as median and interquartile range in the case control study and as mean and 95% CI in the controlled study. A P value of less than 0.05 was considered statistically significant. For primary endpoint outcomes of the controlled study, exact P values are reported. SPSS version 12.2 (SPSS Inc., Chicago, IL, USA) was used.
Part 1: Assessment of postoperative incidence and protective/risk factors for inflammatory response after cardiopulmonary bypass
Part 1. Patient characteristics and associations with inflammatory response after cardiopulmonary bypass
Inflammatory response (n = 34)
No inflammatory response (n = 131)
P value
Age, years
61 ± 12
61 ± 13
Male, number (percentage)
24 (70)
88 (67)
Female, number (percentage)
10 (30)
43 (33)
Body mass index, kg/m2
28.5 ± 5
27.5 ± 4.2
Parsonnet score
13.6 ± 9.2
12.1 ± 6.8
Renal disease, number (percentage)
4 (11)
8 (6)
Diabetic status, number (percentage)
12 (35)
44 (34)
Angiotensin-converting enzyme inhibitors, number (percentage)
10 (29)
45 (34)
Cardiac intervention
Coronary, number (percentage)
19 (56)
81 (62)
Valvular, number (percentage)
9 (26)
41 (31)
Both, number (percentage)
6 (17)
9 (7)
Reintervention, number (percentage)
2 (6)
6 (5)
Surgical data
Total cardiopulmonary bypass time, minutes
101 ± 33
93 ± 33
Aortic clamping time, minutes
61.6 ± 27.3
54 ± 22.8
Tranexamic acid, number (percentage)
8 (26)
78 (60)
No antifibrinolytics, number (percentage)
26 (76)
53 (40)
Intensive care unit stay, days
7.8 ± 6.4
3.2 ± 1.7
Hospital stay, days
17.6 ± 20.5
9.1 ± 6.2
Twenty (12%) of the 165 patients presented VS. In the non-TA group, 16 (20%) out of 79 patients developed VS. As expected, patients with IR were more likely to develop VS (58% versus 0%; P < 0.001). There were 3 deaths (1.8%) in the whole group; none of them had developed IR.
Part 2: Prospective double-blind trial of tranexamic acid effect on inflammatory response after cardiopulmonary bypass
Part 2. Baseline clinical data of controlled study (n = 50)
Tranexamic acid (n = 24)
Placebo (n = 26)
P value
Age, years
66 (63–70)
67 (62–71)
Male gender, number (percentage)
12 (50)
15 (57)
Body mass index, kg/m2
28 (25.8–30.1)
28.1 (36.4–29.7)
Parsonnet score
13.1 (11.8–15.5)
17.5 (13.7–21.3)
Cardiopathy, number (percentage)
13 (54)
12 (46)
9 (38)
10 (39)
2 (8)
4 (15)
Medical treatment
Angiotensin-converting enzyme inhibitors, number (percentage)
11 (61)
7 (39)
Calcium channel blockers, number (percentage)
6 (60)
4 (40)
Preoperative parameters
Platelet count, × 103/mL
210 (186–234)
210 (186–239)
Hemoglobin, g/dL
14.1 (13.5–14.6)
13.6 (12.8–14.4)
International normalized ratio
1.08 (1.05–1.12)
1.09 (1.05–1.14)
D-dimer, ng/mL
250 (166–333)
275 (215–325)
Plasminogen activator inhibitor 1, ng/mL
34.2 (29–39.5)
35.2 (29.4–41.1)
Surgical data
Cardiopulmonary bypass time, minutes
82 (71–94)
85 (74–96)
Aortic clamping time, minutes
51 (44–58)
55 (47–62)
Temperature after cardiopulmonary bypass, degrees Celsius
35.3 (34.9–35.6)
35.1 (34.7–35.3)
Total heparin dose, UI/kg
430 (400–470)
420 (400–440)
Total protamine dose, mg/kg
2.7 (2.5–3)
2.7 (2.6–2.9)
Blood salvage device, mL
681 (605–756)
764 (694–833)
The incidence of IR was significantly lower in the TA group (17%) than in the placebo group (42%) (P = 0.047). TA showed a protective effect for IR (OR 0.1, 95% CI 0.01 to 0.7) after adjusting for Parsonnet score, aortic clamping time, and type of surgery. As compared with the TA group, the relative risk for developing IR was 2.47 for the placebo group (97.5% CI 1.1 to 5.7). The absolute risk difference was 25%. Thus, the number needed to treat to reduce IR was 4 patients (97.5% CI 2 to 20 patients). The incidence of VS was 0% in the TA group versus 23% in the placebo group (P < 0.001).
Part 2. Clinical outcomes of the controlled study
Tranexamic acid (n = 24)
Placebo (n = 26)
P value
D-dimer at 0 hours, ng/mLa
448 (270–625)
1,069 (951–1,189)
D-dimer at 4 hours, ng/mL
499 (364–633)
974 (880–1,069)
D-dimer at 24 hours, ng/mL
433 (280–608)
976 (868–1,064)
Plasminogen activator inhibitor 1 at 4 hours, ng/mL
88 (35–140)
129 (70–188)
Creatine-kinase at 0 hours, U/L
261 (199–322)
327 (270–383)
Creatine-kinase MB at 0 hours, U/L
41 (35–47)
63 (50–77)
STNFR-1 at 4 hours, ng/mL
1,274 (958–1,590)
1,656 (1,175–2,138)
Interleukin-6 at 4 hours, pg/mL
236 (140–332)
362 (250–474)
Interleukin-6 at 24 hours, pg/mL
87 (61–114)
119 (88–151)
Twenty-four-hour bleeding, mL
464 (308–620)
1,037 (771–1,303)
Total bleeding, mL
835 (407–1,263)
1,466 (1,116–1,818)
RBCb units transfused within the first 4 hours (percentage)c
1 (4)
2 (7)
RBCb units until chest tube withdrawal (percentage)c
9 (38)
19 (73)
Plasma units until chest tube withdrawal (percentage)c
1 (4)
8 (31)
Inflammatory response after CPB, number (percentage)
4 (17)
11 (42)
Vasoplegic shock, number (percentage)
7 (27)
Norepinephrine, hours
1.2 (0.5–2.4)
25.4 (5.6–45)
Mechanical ventilation, hoursd
6.5 (5–13.5)
12 (7–24)
Intensive care unit stay, daysd
3 (2–5.5)
3.5 (2–5)
Postsurgical hospital stay, daysd
4.5 (3–6)
4 (2–5)
Part 1: Assessment of postoperative incidence and protective/risk factor for inflammatory response after cardiopulmonary bypass
According to previous reports, it is widely accepted that a systemic response is induced in nearly all patients undergoing open-heart surgery [1]. The occurrence rate of a hyperdynamic state after CPB has been reported to be as low as 4%. [7] and as high as 44% [8]. Indeed, much of the difference in prevalence may relate to the criteria used to define the vasodilatory syndrome [9]. The American College of Chest Physicians/Society of Critical Care Medicine consensus proposed a very sensitive, but very low-specificity, definition for systemic IR syndrome [10]. This definition is often inappropriate for cardiac surgery patients (mechanically ventilated, hypothermic, with pacemakers, and so on), and therefore we applied a definition based on hemodynamic data provided by the latest International Definitions Conference [11]. Other studies have proposed definitions based on analytical data such as high levels of IL-6 [12], whose serum concentrations correlate with morbidity and mortality following pediatric cardiac surgery [13]. The present study has shown that patients who fulfilled clinical criteria also had higher levels of IL-6. Therefore, the definition used seemed to be suitable to identify protective or risk factors for IR after CPB, even though this clinical picture may vary from mild to severe form. IR was found in one fourth of the patients, of whom more than half developed VS. TA was significantly associated with a lower incidence of IR. The incidence in those patients who did not receive TA was nearly one third, similar to other reports [12]. Thus, the next step was to test this hypothesis using an experimental design.
Part 2: Prospective double-blind trial of tranexamic acid effect on inflammatory response after cardiopulmonary bypass
The trial was interrupted by the ethics committee due to the adverse effects (excessive bleeding) observed in the placebo group during follow-up. Our results indicate that TA reduces the incidence of IR and VS in CPB patients as well as postoperative bleeding and hemoderivative requirements. Several mechanisms have been proposed to explain the development of IR after CPB, such as contact activation, ischemia-reperfusion, and endotoxemia. These initiating factors may activate numerous systems involving complement, cytokines, immune cellular response with dysfunction of endothelium, and alteration of coagulation-fibrinolytic cascades [1]. This activation exposes patients to either immediate risk of major bleeding [14] or IR, as we saw in the first part of the study. The IR in cardiac surgery is closely related to hemostatic alterations. [15]. In this sense, higher D-dimer and IL-6 levels have been found in CPB patients with vasoplegic syndrome. [16]. In fact, IR and major bleeding could be considered as final outcomes of the same triggering stimulus, so that hyperfibrinolysis could play an important role in these processes. [17, 18]. The suppression of excessive plasmin activity or D-dimer formation may play an important role in the generation of proinflammatory cytokine (IL-6) during and after CPB [5], which has been reported to be involved in circulatory dysregulation and metabolic derangement [4].
TA, an antifibrinolytic agent. [19], reduces bleeding and transfusion requirements after cardiac surgery. [20, 21]. A synthetic derivative of the amino acid lysine, TA exerts its antifibrinolytic effect through the reversible blockade of lysine-binding sites on plasminogen molecules. However, the effect of TA on IR during cardiac surgery and CPB has received little attention [22]. In our study, low levels of D-dimer at all postoperative time points in the TA group clearly suggest that these patients experienced less secondary fibrinolysis which leads to reduced postoperative bleeding. Lower levels of PAI-1 at 4 hours may reflect less previous activation of fibrinolysis with less secondary production. We observed no striking changes in coagulation and complement parameters in the TA group. However, STNFR levels and IL-6 levels at 4 hours, which have been implicated in the development of postoperative morbidity after CPB [23], were lower, as were myocardial enzymes on admission, which may reflect a reduced IR [24] and thus less perioperative insult. Casati and colleagues [25] have proven that TA can effectively decrease postoperative IL-6 levels in this context. Blood transfusions are able to alter the IR, including cytokine concentrations of IL-6. However, we suppose that an influence of transfusions on the postoperative development of IR can be ruled out by the fact that only three patients were transfused before setting up the clinical criteria for IR. Furthermore, the number of red blood cell units given during the first hours of the postoperative period did not differ significantly between groups. Finally, due to the fact that vasodilator drugs may interact with vascular resistance, the inclusion of temperature as part of the clinical criteria rules out the confounding effect of these drugs.
The TA patients needed smaller amounts of vasopressors and shorter duration of mechanical ventilation. Greater bleeding may lead to higher doses of vasopressor but not simply because of a direct mechanistic principle. Other factors are implicated; there is evidence that several shared key components of IR are activated in major bleeding [26] and in vasoplegia after CPB. [16]. Therefore, we may consider that the use of a vasopressor does not depend exclusively on the amount of bleeding. We believe that TA could attenuate inflammatory changes through blockade of fibrinolysis and may modulate interactions between the different systems involved in the global response to CPB [1].
Limitations of the study
Even though greater postoperative bleeding was associated with IR after CPB, a limitation was the failure to determine fibrinolysis parameters in the first part of the study. The main limitation of part 2 of the study is the sample size. However, this was a randomized controlled study and baseline data were comparable between groups. Additionally, although inclusion of patients was prematurely stopped, data analysis demonstrated that TA attenuates IR in patients after CPB. This small sample size could lead to a type II error regarding secondary endpoints, such as durations of hospital stay and ICU stay.
The use of TA attenuates the development of IR and VS after CPB, with hyperfibrinolysis playing a predominant role in their development.
Key messages
Hyperfibrinolysis may play a role in inflammatory response (IR) after cardiopulmonary bypass (CPB).
Inhibition of fibrinolysis with tranexamic acid may attenuate IR after CPB.
confidence interval
cardiopulmonary bypass
intensive care unit
inflammatory response
odds ratio
plasminogen activator inhibitor 1
prothrombin time
soluble tumor necrosis factor receptor
tranexamic acid
vasoplegic shock.
The authors thank the staff of the Intensive Medicine Unit and Hematology Department (Hospital Universitario de Canarias, La Laguna, Spain) for their invaluable collaboration in this study. This study was supported by FUNCIS (Fundación Canaria de Investigación y Salud) 2202.
Authors' Affiliations
- Laffey JG, Boylan JF, Cheng DC: The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology 2002, 97: 215-252. 10.1097/00000542-200207000-00030View ArticlePubMedGoogle Scholar
- Taneja R, Yared JP, Hammel J, O'Connor MS, Insler S, Starr NJ: Hyperdynamic circulation following cardiopulmonary bypass predisposes to postoperative bleeding. Critical Care 2001,5(Suppl 1):P110. (2 March 2001)PubMed CentralView ArticleGoogle Scholar
- Tuman KJ, McCarthy RJ, O'Connor CJ, Holm WE, Ivankovich AD: Angiotensin-converting enzyme inhibitors increase vasoconstrictor requirements after cardiopulmonary bypass. Anesth Analg 1995, 80: 473-479. 10.1097/00000539-199503000-00007PubMedGoogle Scholar
- Cremer J, Martin M, Redl H, Bahrami S, Abraham C, Graeter T, Haverich A, Schlag G, Borst HG: Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg 1996, 61: 1714-1720. 10.1016/0003-4975(96)00055-0View ArticlePubMedGoogle Scholar
- Greilich PE, Brouse CF, Whitten CW, Chi L, Dimaio JM, Jessen ME: Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: a randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin. J Thorac Cardiovasc Surg 2003, 126: 1498-1503. 10.1016/S0022-5223(03)00946-2View ArticlePubMedGoogle Scholar
- Cvachovec K, Horacek M, Vislocky I: A retrospective survey of fibrinolysis as an indicator of poor outcome after cardiopulmonary bypass and a possible early sign of systemic inflammation syndrome. Eur J Anaesthesiol 2000, 17: 173-176. 10.1046/j.1365-2346.2000.00643.xView ArticlePubMedGoogle Scholar
- Gomes WJ, Carvalho AC, Palma JH, Teles CA, Branco JN, Silas MG, Buffolo E: Vasoplegic syndrome after open heart surgery. J Cardiovasc Surg (Torino) 1998, 39: 619-623.Google Scholar
- Kristof AS, Magder S: Low systemic vascular resistance state in patients undergoing cardiopulmonary bypass. Crit Care Med 1999, 27: 1121-1127. 10.1097/00003246-199906000-00033View ArticlePubMedGoogle Scholar
- Johnson MR: Low systemic vascular resistance after cardiopulmonary bypass: are we any closer to understanding the enigma? Crit Care Med 1999, 27: 1048-1050. 10.1097/00003246-199906000-00008View ArticlePubMedGoogle Scholar
- Vincent JL: Dear SIRS, I'm sorry to say that I don't like you. Crit Care Med 1997, 25: 372-374. 10.1097/00003246-199702000-00029View ArticlePubMedGoogle Scholar
- Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003, 31: 1250-1256. 10.1097/01.CCM.0000050454.01978.3BView ArticlePubMedGoogle Scholar
- Kilger E, Weis F, Briegel J, Frey L, Goetz AE, Reuter D, Nagy A, Schuetz A, Lamm P, Knoll A, et al.: Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery. Crit Care Med 2003, 31: 1068-1074. 10.1097/01.CCM.0000059646.89546.98View ArticlePubMedGoogle Scholar
- Hauser GJ, Ben-Ari J, Colvin MP, Dalton HJ, Hertzog JH, Bearb M, Hopkins RA, Walker SM: Interleukin-6 levels in serum and lung lavage fluid of children undergoing open heart surgery correlate with postoperative morbidity. Intensive Care Med 1998, 24: 481-486. 10.1007/s001340050600View ArticlePubMedGoogle Scholar
- Despotis GJ, Avidan MS, Hogue CW Jr: Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. Ann Thorac Surg 2001, 72: S1821-S1831. 10.1016/S0003-4975(01)03211-8View ArticlePubMedGoogle Scholar
- Baufreton C, Corbeau JJ, Pinaud F: [Inflammatory response and haematological disorders in cardiac surgery: toward a more physiological cardiopulmonary bypass]. Ann Fr Anesth Reanim 2006, 25: 510-520. 10.1016/j.annfar.2005.12.002View ArticlePubMedGoogle Scholar
- Iribarren J, Jimenez J, Brouard M, Lorenzo J, Perez R, Lorente L, Nuñez C, Henry C, Martinez R, Mora ML: Vasoplegic syndrome after cardiopulmonary bypass surgery associated factors and clinical outcomes: a nested case-control study. Crit Care 2007,11(Suppl 2):P254. (22 March 2007) 10.1186/cc5414PubMed CentralView ArticleGoogle Scholar
- Syrovets T, Jendrach M, Rohwedder A, Schule A, Simmet T: Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation. Blood 2001, 97: 3941-3950. 10.1182/blood.V97.12.3941View ArticlePubMedGoogle Scholar
- Robson SC, Shephard EG, Kirsch RE: Fibrin degradation product D-dimer induces the synthesis and release of biologically active IL-1 beta, IL-6 and plasminogen activator inhibitors from monocytes in vitro . Br J Haematol 1994, 86: 322-326.View ArticlePubMedGoogle Scholar
- Dunn CJ, Goa KL: Tranexamic acid: a review of its use in surgery and other indications. Drugs 1999, 57: 1005-1032. 10.2165/00003495-199957060-00017View ArticlePubMedGoogle Scholar
- Karkouti K, Beattie WS, Dattilo KM, McCluskey SA, Ghannam M, Hamdy A, Wijeysundera DN, Fedorko L, Yau TM: A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion 2006, 46: 327-338. 10.1111/j.1537-2995.2006.00724.xView ArticlePubMedGoogle Scholar
- Diprose P, Herbertson MJ, O'Shaughnessy D, Deakin CD, Gill RS: Reducing allogeneic transfusion in cardiac surgery: a randomized double-blind placebo-controlled trial of antifibrinolytic therapies used in addition to intra-operative cell salvage. Br J Anaesth 2005, 94: 271-278. 10.1093/bja/aei044View ArticlePubMedGoogle Scholar
- Asehnoune K, Dehoux M, Lecon-Malas V, Toueg ML, Gonieaux MH, Omnes L, Desmonts JM, Durand G, Philip I: Differential effects of aprotinin and tranexamic acid on endotoxin desensitization of blood cells induced by circulation through an isolated extracorporeal circuit. J Cardiothorac Vasc Anesth 2002, 16: 447-451. 10.1053/jcan.2002.125145View ArticlePubMedGoogle Scholar
- Marano CW, Garulacan LA, Laughlin KV, Igidbashian L, Trace C, Goldman SM, Sutter FP, Reichard GA Jr, Mullin JM: Plasma concentrations of soluble tumor necrosis factor receptor I and tumor necrosis factor during cardiopulmonary bypass. Ann Thorac Surg 2000, 70: 1313-1318. 10.1016/S0003-4975(00)01932-9View ArticlePubMedGoogle Scholar
- el-Barbary M, Khabar KS: Soluble tumor necrosis factor receptor p55 predicts cytokinemia and systemic inflammatory response after cardiopulmonary bypass. Crit Care Med 2002, 30: 1712-1716. 10.1097/00003246-200208000-00006View ArticlePubMedGoogle Scholar
- Casati V, Della Valle P, Benussi S, Franco A, Gerli C, Baili P, Alfieri O, D'Angelo A: Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: comparison between on-pump and off-pump techniques. J Thorac Cardiovasc Surg 2004, 128: 83-91. 10.1016/j.jtcvs.2003.10.034View ArticlePubMedGoogle Scholar
- Jimenez JJ, Iribaren JL, Raya JM, Nassar I, Lorente L, Perez R, Brouard M, Lorenzo JM, Alarco B, Martinez R, et al.: Factors associated with excessive bleeding in cardiopulmonary bypass patients: a nested case-control study. J Cardiothorac Surg 2007, 2: 17. 10.1186/1749-8090-2-17View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Welcome to WebmasterWorld Guest from 220.127.116.11
Forum Moderators: mademetop
Not just Google, but all the major players in the search and blogging spheres. However, this is a Google initiative.
The specific method described is correct, and the rel attribute is designed to mark "untrusted links".
blog announcements:
True, but only if it comes from the sort of site that google approves of.
I dont think its meant to be that black and white - not all links will or should have the nofollow tag attribute. obviously, it will be up to individual blog owners to decide which links out are valid and which are just spammy links. Google will index those links denoted to be valid (not spam). So the shaping of the web falls upon the blog owners.
I think that this (tag) attribute could be abused by people wanting to set up fake reciprocal links etc. But, to me, the whole web is "caveat emptor".
When you set up reciprocal links, its wise to monitor them automatically. The new tag attribute just means an additional step in that verification process.
<edit>change tag to tag attribute</edit>
and in regards to BAD use of this, let me share a few steps forward thinking with you, the SE will be able to detect blogs spammers by seeing how many backlinks from that TAG they have, sounds ok, doesn't it, WRONG! by doing that the spammers will be able to spam using a legitimate site url and make the SE "THINK" it belongs to a spammer and take it of the SERPs.
I dont think its meant to be that black and white
Doesn't matter what it's meant to be; only what it will be if this idea is really unleashed.
such as
2) Artifical link manipulation
In essense, giving a SE a different picture of a web site by closing off pages you care less about for ranking reasons. This coin obviously has two sides since there are legit reaons. But those were easily handled with noindex instructions. Now we can subdivide individual links and reroute PR in increasingly artificial ways. Just more power to the SEO, which is not really what G wants, and certainly puts the innocent webmasters at huge disadvantages. And don't think about single sites here. Think about the profound effect it would/will have on the entire Web.
What if a news site decides some lesser pages are not worth finding, in favor of bigger pages that draw more ad dollars. Result: poorer quality.
Of course, gee, now that I think about it...my affiliate links no longer need be java redirected. Hmmm.
3) Nevermind, I've got work to do. :/
OMG, this could radically and negatively change the face of the entire web, since the web no longer has a face except thru the eyes of SE's, for the most part.
With only a few minutes to consider this, seems that PR manipulation just became a sport for the novice.
Oh, and BTW, does anyone think this will stop the majority of blogspam? Puhleese. Something might. This won't.
<added>I need to take a deep breath. I'm sure that I'm just not getting it somehow. So many smart SE's couldn't be wrong.</added>
Nah. It changes the SEO game a little bit.
How many people really look at tag attributes when they use CMS driven sites? How many people use HTML authoring packages like Frontpage?
One of the key lessons I learnt from the senior members here is to not look at the web from your own myopic view. We tend to live on the bleeding edges and have a very skewed view.
For those whose world revolves around blog links, Six Apart could roll out a plug in which allows a visitor to donate a configurable amount via paypal. If the said donation is made the links for that user would not be made nofollow. ;)
Engines can still follow the tag and remove the link from its ranking algorithms. From little I know, crawl/index and rank algorithms should use a different set of criteria.
Possibly more than a little...but I'll grant that "radically" was perhaps too strong a word. :-)
I'm no tech guy but I"m wondering if this can be confined for use in just blogs, forums, etc.? I doubt it. If not, this seems to offer a tool for manipulating entire websites on a micro level (one link at a time). Smaller innocents can't / don't have the knowledge / time / patience to do this or learn the tools that can help them do this. It puts another signficant tool in the hands of the SEO at the expense of the little guy.
As one recent example, Florida was a blow to the little guy, albeit from an entirely different angle. This is quite possibly another if it's real and can be manipulated as easily as it appears on first glance. The little guy just doesn't know it yet. Florida changed the accessible web. This could too. Little guys get pushed further and further and further down in the SERP's. Anyone seen a trend towards smaller doing better in the SERP's lately? Ummm, not.
This new tag seems to have the potential to be good for larger companies/sites with resources...and bad for the little guy. If it comes to pass, that's a substantial shift, and not a good one IMHO/. OTOH, nothing new as far as the trend goes. :-/
I can already see the day when G will need to decide whether or not to punish non-blog sites that use this tag for PR manipulation. Good grief.
I'm not ready to *any* make changes just yet. We'll wait and see just exactly how this is implemented, and how the SE's bend its use contextually, if at all. But it strikes me that this has the possibility of forcing us - for the first time since Florida - to look hard at the way our sites and links are sructured....or lose the advantage to those who do it while we sit idly by.
Does this mean that when we do reciprical linking we are going to have to view the source code to ensure that tag is not added?
Uh, you mean that you don't currently check the source of the google cache of your page?
I don't do link exchanges, but if I did, I would want to check what Google sees, not what looks like a link to me. This new attribute has noting to do with this, I've been cloaking or using javascript to hide links from the search engines for years.
This will be another tool shady webmasters can use after they setup a reciprocal link exchange.
As if they aren't doing it already, only using other techniques. Maybe, just maybe, this will put real links, put up by interest and the will to inform others, back on the web.
Also this new tag will help only those blogs where the blog is updated by its owner. There are huge number of blogs, message boards and guest books out there that are abandoned. Their owners have simply not updated those sites in last many months or even years. Such blogs are the target of comment spammers and they will continue to remain so for a long time to come.
When search engines start making manual adjustments and specific algo adjustments to fix one problem rather than tackling the issues within the basic premise of their algo the battle has been lost and the door is open for a new contender.
It's slightly bemusing that this is being seen as an attack on comment spam, when IMO it's clearly a PR exercise for search engines and blog software owners.
As others have mentioned, it does nothing to solve the problems of large-scale comment abuse - but it does allow the two sides to address the negative PR that they were receiving on this issue from "important" blog users. (And it has allowed some critical bloggers to increase their self-importance to such a stage that their heads might well explode...)
And, every time, the change is in line with the original description of the purpose.....which was not, ever, simply counting backlinks. Backlinks are a way of arriving at pagerank, but not the exclusive way.
Tbe paper says:
Academic citation literature has been applied to the web, largely by counting citations or backlinks to a given page. This gives some approximation of a page's importance or quality. PageRank extends this idea by not counting links from all pages equally, and by normalizing by the number of links on a page.
Academic citation indexes have long discounted self-citation and circular citations.
The addition of rel="nofollow" simply allows a site owner to state unambiguously if the citation is a recommendation endorsed by the site owner or not.
Links were never meant to be counted equally (see above quote), so adding distinguishing marks is a smart idea.
Links were never meant to be counted equally (see above quote), so adding distinguishing marks is a smart idea.
Surly the purest view is that most sites are not built with Google PageRank in mind.
You could ask, why would webmasters start using this tag as the default? The answer is, why wouldn't they? They can use this tag to block PageRank transfer and stop giving credit to other sites.
If use of the tag on regular websites starts to become widespread then it will rollercoaster and there will be hardly any "real" links left. What happens then?
I can't understand the need for a new tag. Why they couldn't have modified the popular blog scripts like MT, wordpress etc. to convert all regular links in blog comments to the Java script links?
If the search engines had to come up with this solution it means their algorithms could not handle blog links.
It's slightly bemusing that this is being seen as an attack on comment spam, when IMO it's clearly a PR exercise for search engines and blog software owners.
The bottom line is: anything we can do to halt spam should be welcomed.
Then the web ceases to be a set of interconnected pages, but an isolated collection of islands
Not at all.
That would degrade the value of search engines. But it wouldn't change the web at all. Every single link would still work.
But the engines are simply moving the onus onto the blogs/site owners to implement this tag because they could not do it from their remote location.
And it would have been even better if they'd added an endorsement factor:
Then site owners could make it clear what the strength of a link is -- ie what they intended when they made the link.
The "all links are equally important endorsements" view is clearly so 20th Century in its naivity that it is time for a change.
My first thoughts exactly. I think a lot of merchants just woke up with a major headache. Not to mention the endless opportunities this opens up for manipulation.
I see a lot of busy webmasters over the next few weeks.
News flash! Knowledgable webmasters are already implementing this same feature in a hundred different ways and the search engines see it in our code. They're letting us accomplish the same thing our javascript links accomplish in a standards based and simpler way.
If you think this means that "suddenly search engines are deciding how the web works" then you've missed the last five years.
If you think this is a new way for reciprocal linkers to lie to you, then you have no idea how bad you're already being lied to. This isn't shady, it's in the HTML source of the page.
"But it will be manipulated!" Yes, it will. Once a site starts to manipulate it, then each search engine will likely turn off that attribute's effect on a per site basis. Sites which use the tag for it's intended purpose will have the attribute taken into account. Just like semantic markup, it only matters if you use it.
If the new attribute was only used for un-moderated comments, then that would seem ok, but tarring all comments with the same brush seems to degrade the community building aspect of blogging. I've always felt blogging is different from ordinary websites, as it encourages trackbacks and commenting. This would seem to be a step backwards for blogging, to solve a problem that is better solved by moderating comments first.
Oh wait, it is ALREADY available in the headers, bloggers are just not using it.
I also forsee a new kind of cloaking - humans get regular links, engines get rel="nofollow" added to all anchors.
Link exchange? No problem, because it won't weigh the page down.
Ya, that is a whole different story than if just Google alone were doing it. I am really surprised G let the story set out there the way it was without correction - (they had ample opportunity to correrct it too).
> humans get regular links, engines
> get rel="nofollow" added to all anchors
Bot content for bots - human content for humans. Been doing that for years.
> Way to block links.
Exactly. Now you can link out without having to hide it from the bot.
How about short changing your recip linking partners with cloaking? Is this the rebirth or death of organic linking?


text:
Banana and coconut is a wonderful flavour combination, and when you add honey and oats into the mix, it makes for a dreamy banana granola that's far simpler and quicker to prepare than you might think.
It's also far healthier than most packet cereals and comes in at a fraction of the cost of shop-bought granola, so why not give this easy and truly delicious recipe a go?
- 250g (9 oz) jumbo oats
- 50g (2 oz) banana chips, roughly broken into 1-2cm pieces
- 25g (1 oz) coconut chunks or dried slithers
- 6 tbsp runny honey
- 2 tbsp olive oil, coconut oil or sunflower oil (plus a little for greasing)
- Preheat the oven to 180C (160C fan assisted). In a bow, mix all of the ingredients together until evenly combined.
- Press the mix into a greased tray. The idea with this granola is to get nice clusters at the end.
- Bake for 15-20 until lightly browned. Remove from the oven and allow to cool completely, then break up into 1-2.5cm pieces. Store in an airtight container to keep it fresh.
I like mine with yoghurt and a little fresh fruit, but it's equally delicious with a splash of ice cold milk. How will you eat yours?
Pin this recipe for later – just hover over the image below until you see the Pin It button!
This recipe originally appeared on Avon and has been rehomed here. Do check out my Avon food blog – I pop a new recipe up over there about twice a month.


text:
Storage Elements Launches First Mac OS RAID System
News Analysis: The company claims the industry's first comprehensive Mac OS X-based, iSCSI/FCNAS unified storage server on the market, and it may be right.SAN FRANCISCOOutside of Apples introduction of the iPhone earlier this week, there really werent that many breakthrough-type products at the Macworld Conference and Expo, which ended Jan. 12. But one of the few was a new data storage software system exclusively for Mac OS X produced by a small and relatively unknown software developer and hardware integrator called Storage Elements, of Minneapolis, Minn. Mythos iSCSI Storage Server is an enterprise-ready hardware-software package designed specifically for Mac OS X servers. President and CEO Brad Wenzel of Storage Elements told eWEEK that this is the industrys first comprehensive Mac OS X-based iSCSI/FCNAS unified storage server on the market, and a look around the Internet indicates that he might be right.
"This product, launched at the show this week, is the first enterprise-level RAID system developed for the Mac OS," Wenzel said. "Weve been working in the field a long time, and weve put about six years into building this system."
Loading Comments...


text:
Current / Slices
Hip-hop star and anti-addiction advocate Macklemore recently joined President Obama to discuss the dangers of a rising problem in America: addiction to prescription pain killers.
The reality of the problem is shocking. As the president notes, drug overdoses now kill more Americans every year than traffic accidents. And, in the last 16 years, the number of Americans who have died after overdosing on opioids has tripled. And, because the the pain killers are prescribed by doctors, more and more Americans are getting access to the medicines that could also become the source of deadly addictions.
Macklemore, who himself overcame addiction with the help of recovery resources and a 12-step program, has been vocal about the drugs' danger. Along with advocating for new legislative measures—including training for doctors and additional resources to first-responders helping overdose victims—the duo announced that they are creating a new MTV special to help raise awareness about the issue. It will air later this summer. Discuss
Culture / Slices
Any Friends fan could tell you their favorite moments of the beloved show. The flag football Thanksgiving episode, the time Chandler Bing becomes Ms. Chanandler Bong, the one where Chandler and Monica finally get together, and of course, who could forget the time the gang went to Vegas? Well, as it turns out, Matthew Perry could. In recent interview with BBC Radio 2 about his play The End of Longing, the Friends actor revealed that he couldn't really remember filming seasons three through six of the NBC sitcom. When asked what his least favorite episode to film was, Perry responded, "I think the answer is, I don't remember three years of it. So none of those … Somewhere between season three and six ... I was a little out of it." Perry struggled with alcohol and painkiller addiction during his time on the show. He told People in 2013, "I couldn't stop. Eventually, things got so bad that I couldn't hide it, and then everybody knew." Discuss


text:
The Horse Forum (http://www.horseforum.com/forumindex.php)
- Horse Pictures (/horse-pictures/)
- - My horse Bert (http://www.horseforum.com/horse-pictures/my-horse-bert-112994/)
My horse Bert
This is my new buddy bert only a few months of haveing him and we are two peas ina pod
384 Attachment(s)
Hi, welcome to the forum, great pic of you & Bert. I used to live in Surrey years ago when I could ride my horse along aside of King George Hwy, so you know that is many, many years ago, lol.
Handsome boy, welcome to the forum!! What breed is Bert and how old is he?
Bert is 7 years old and he is a standardbred an ex-race horse and as calm as a quarter horse :}!
Welcome Western Rider
you have a very nice horse
He sure is a good looking guy!
He looks like a character!
thank you for the comments Bert is a bratty good boy if that make sense at all XD hes soo good i cant even ground tie him because he just follows me evverywhere and if im brushing him and have treats in my pocket he nips my butt!!!
how tall is he? and how long have you had him for?
|All times are GMT -4. The time now is 12:42 PM.
Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2017, vBulletin Solutions, Inc.
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.