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Direct Democracy - an agenda for a new model party
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"One of the founding texts for the new, revitalised Toryism... written by some of the brightest young Conservative thinkers" says The Spectator.
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Building A State of Responsible Democracy
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The states that have gained their independence or have been established in the post-war period are usually called democracies, but lately there has been more and more criticism directed towards... More > democracy. A specifically pessimistic tune particularly stands out, stating that democracy can only function properly given a society with strong moral convictions. Looking at these negative opinions in more detail reveals the real reasons for this phenomenon. We arrive at the conclusion that the functioning of democracy could be improved.< Less
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A photo narrative of Apache Troop 1/278th Regimental Combat Team's deployment to Iraq, 2004-2005. A general description of a typical combat tour for a National Guard Unit deployment. There are combat... More > descriptions, normal operations, and unique to the A Troop, 1/278th located on FOB Caldwell were the training and joint missions with the Iraqi Army's first operational Battalion, Brigade, and Division. The 1/278th Military Transition Teams directly influenced the success of this primary mission. The 278th RCT members also monitored the first Iraqi elections enabling a successful outcome.< Less
Direct Democracy in the European Union of the 21st Century: Utopia or Inevitable Pillar in Community Governance?
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America is facing major challenges that require our leaders to put the interests of the people first, not the interests of those with the funds to support the next election. Our elected leaders do... More > not spend enough time listening to us when defining the direction of our government. The time has come for the American people to set the agenda. Jim Brandt has applied the business concepts he used over an entire career to a practical plan to advance real democracy in America. He presents a detailed plan that includes everyone regardless of their experience or available time. We must stand up to big money and special interests. The plan, supported by the Polly Dicta website, will help us give real democracy a voice.< Less
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Prepare to understand contemporary politics as never before! Prepare to see the future of American democracy! A recent study at Princeton University came to a shocking conclusion. Our system has... More > been so corrupted by money and influence peddling, America is no longer a democracy. This manifesto offers a detailed, step-by-step plan for cleaning up the corruption in Washington DC, replacing the current crop of pay-for-play politicians with progressive, independent, minor-party candidates, who will be bound by legal contract when elected, to faithfully serve the interests of the voting public. This is electoral reform so radical that in one master stroke, it puts America on the path to a healthy economy and directly addresses its #1 and #2 challenges: the suicidal march to war and the destructive impact of a historically high level of wealth inequality. Brace yourself for a real game-changer which will redefine politics for the foreseeable future.< Less
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Western democracies are democracies too often unjust. People sometimes have the illusion of governing but in fact it is always the same persons who are elected and govern as they want. This must... More > change. We must imagine a truly democratic and just constitution in order to offer happiness to our people.< Less
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This book is made up of a collection of articles written by us over the period since the fall of 'die Mauer' and the crisis of the European socialist movement brought on in its wake. They... More > record an attempt to argue through the theoretical challenges that this period has posed: ● Why did both Leninist communism and social democracy come to crisis? ● What were the economic weaknesses of both and what economic policy should a future socialist movement adopt to overcome these? ● How can the struggle for popular democracy be integrated into the goals of a new movement?< Less
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One beautiful boat, huge spec, incuing all the Med kit and stabilizers. Fastidiously maintained from new and very low hours. Tristar III was the second Trader built for the same long-standing boating family - a great opportunity to benefit from that experience.
The hull, deck superstructure and flybridge in three separate GRP mouldings
Heavy hand lay-up using woven rovings and chop strand mat with integral stiffening
Four full width plywood bulkheads bonded to hull and deck, complete with bonded longitudinals with hardwood inserts which form the engine bearers complete the hull stiffening
All skin fittings on or below the waterline are in bronze, complete with gate valve
Anodes - transom mounted, on rudders and bonded to all major underwater fittings
Hull Epoxy treatment
Stainless steel opening potholes in all cabins, with insect nets
Coloured boot top + stripes
Full perimeter stainless steel rub rail
Large outward opening transom ports (escape size)
Integrated teak laid bathing platform, with "Sea-stair" access to aft deck
Deck superstructure bolted and bonded to hull along bulwark line, with the joint capped in stainless steel.
Forward coach roof in non-slip GRP
Watertight sliding wheelhouse door
Coloured stripes
Stainless steel framed windows in saloon (3 opening)
Windows throughout in safety glass with extra dark tint
TRADER stainless steel badges
Boat hooks stored in superstructure
Aft deck access to saloon
Main deck sheathed in prime quality teak with PRC black caulking compound between planks
Stainless steel handrails
Teak laid side and fore decks
Toe rails on foredeck
Deck fillers – fuel, water(transom) and holding tank pump out (4)
Twin shore power sockets – waterproof HUBBELL type
Stainless steel foredeck hatch (escape hatch size) to VIP Stateroom
Additional deck hatch to twin fwd cabin
Navigation lights: port, starboard, steaming, stern and anchor
Side deck lighting, low level and under flybridge coaming.
Teak laid flybridge
Flybridge seat units with cushions and stowage underneath
GRP helm console
Stainless steel handrail around flybridge
Stainless steel steps with hand rail and teak treads to flybridge
Windscreen for flybridge helm
GRP mast for mounting radar and antenna
Low level bulkhead lighting
Flybridge aft drains run internally to waterline
Drinks locker with drain
Cup and bottle holders
Teak laid aft deck
Teak ensign staff with stainless steel base
Shower in transom locker
Teak bathing platform
S/s boarding ladder under bathing platform
GRP aft deck canopy together with lights
Stainless steel doorway to saloon
Enlarged GRP seating unit with GRP table
Bow platform with GRP base for anchor stem head fitting
Electric MAXWELL horizontal windlass with 2-way remote control 70 metres calibrated galvanised 3/8'' chain
CQR type 35kg bow anchor stainless steel
Foredeck hatch to chain locker, with lift out GRP storage bin
Cleats - forward and aft bollard type with fairleads
Spring cleats, two each side
Fenders complete with lanyards
Stainless steel fender baskets
Twin electric horn unit
ALMAR hydraulic passarelle (350kg lift)
AVON 3.14 RIB tender with HONDA 20hp outboard, with electric tilt
All external seating and sun pads made in marine grade vinyl with water resistant closed cell foam, and mesh bases
Flybridge helm console cover
"Caribbean" style Bimini top
Covers for f/b seating, helm, aft deck seats tables, windows
Twin resiliently mounted diesel engines, close coupled to gear boxes with handed reduction boxes driving via stainless steel propeller shafts running in stern glands with water lubricated bearing in shaft log, intermediate and 'A' brackets, both with water lubricated bearings
POSEIDON drive thrust bearings and flexible couplings for smooth running
Engine monitors - electric type with displays at main and flybridge command positions - tachometer, volts, oil pressure, water temperature, oil and charge warning light, stop and start switches
Engines are fresh water cooled, with salt water cooled heat exchanger and water jacketed exhaust manifold engine and gear box oil coolers
Single lever electronic throttle and gear, with control heads at main and flybridge positions
Water injected exhaust system, with dual chamber silencers
Cleanable bronze sea water strainers to each engine
Five bladed handed turbine profile props in bronze by POSEIDON, secured to propeller shafts by taper key and nuts
24 volt electrics, negative earth
WESMAR hydraulic bow thruster with RS400 stabilizers
Additional anodes above shafts
Halyard exhaust overheat alarms
Twin station hand hydraulic steering with variable ratio helm units
Twin fabricated stainless steel rudders carried in lower and upper bearings complete with emergency tiller steering
All pipe work is in copper, except for the length between the check valves and the ram, which is in correctly rated hydraulic hose
Twin steel fuel tanks complete with balance pipe, deck fillers and breathers, tank mounted sight gauges with fuel shut offs
Fuel system layout allows either engine to draw from either tank
Fuel pipe work to engine via filters with water traps
Fuel gauges at lower helm for wing tanks
GRP water tank aft, complete with deck filler, breathers, electronic level gauge and sight gauge
Hot water is heated by engine coupled VETUS calorifier with 240v immersion heater
Fresh water service lines (hot and cold) in copper
Electric pressure pump and accumulator set
Water tank gauge in galley
2 shower sump pumps
JABSCO QUIETFLUSH electric toilets in both head, with salt and fresh water operation
Holding tank with macerator, contents gauge at lower helm and y-valve for deck pump out. Shut off valve between tank & pump
Automatic bilge pumps
Manual bilge pump
ONAN 13.5kW generator with independent start battery
6 heavy duty 12v batteries - approx. 220 amp hrs each. Two dedicated to engine start, the others to domestic supply. Run as 24V systems
80 a.h. semi-automatic marine battery charger operates from shore power, or generator
2.5kW inverter
All circuits throughout the vessel are protected by circuit breakers complete with volt and amp meters mounted on electrics panel in wheelhouse
Vessel wired for 220v/240v sockets (ring main) immersion heater (also heated via fresh water from engine) and battery charger
All wiring throughout the vessel is multi-stranded copper, sheathed, colour coded and run in looms
Two waterproof HUBELL type deck sockets for twin shore line connections
Battery master and AC selector in wheelhouse electric panel
Full MARINE AIR reverse cycle air-conditioning
Four hand held powder fire extinguishers in accommodation
Automatic fire extinguisher in engine room
Fire blanket in Galley
Emergency tiller
Exhaust overheat alarms
6 man liferaft
6 life jackets
2 throw lines
Searchlight (remote control)
SEEME radar reflector
Large grain teak timber trim
Teak laid floor with contrasting holly splines
Carpet throughout (whipped)
Vinyl ceilings
Deck head halogen lighting
Berth reading lights and opening portholes in all cabins
Rubber non-slip treads on internal steps
Solid timber internal doors
CD stereo system, with fb & aft deck speakers and controls
TV cabinet in saloon with TV and DVD player
TV cabinet in master stateroom
Water tight flush fitting pilot door
Bar unit under helm seat
Forward stowage for charts
L-shaped dinette seating to port
Bench seat to stbd
Helmsman's seat with steering wheel and engine console
High – Low table (movable)
Full length overhead handrails
Spiral staircase to aft deck
Drinks fridge
Copious storage, including full length hanging lockers with internal lights and drawers
Dressing table and seating in Master Stateroom
Opening stainless steel portholes
Full length mirrors in VIP & Master Staterooms
Concealed blind on VIP overhead hatch
Sprung mattresses throughout
Dehumidifier in Master Stateroom
TV cabinet in Master Stateroom
Showers with hot and cold mixer taps, soap holders and separate drain trays
Wash basin with hot and cold mixer taps
Marble counters
Vanity mirrors
Co-ordinated rails and accessories
Heated towel rail in master bathroom
Teak louvered doors and drawers for under work top stowage
Corian surfaces
Further overhead stowage lockers
Access to engine room under stairway
Large work top with deep stainless steel double sink, hot and cold mixer taps and waste unit
Ceramic hob - SMEG
Electric Oven - SMEG
Fridge/Freezer - ISOTHERM
Deck head extractor fan
OCEANAIR Venetian blinds
Lower Helm Station
Full engine controls and instruments
Major compass with night illumination
3 variable speed windscreen wipers with washers
Chart table & chart light
Electrics panel
Console for mounting instrumentation & accessories
Upper console for mounting of accessories
Upper Helm Station
Flybridge compass with illumination
Full engine controls and instruments
Navigation aid repeaters
Console for mounting of accessories
Navigation Aids
SIMARD radar and plotters
Log & Depth
Auto helm pilot (dual station)
Fish finder
Handheld VHF
The Company offers the details of this vessel in good faith but cannot guarantee or warrant the accuracy of this information nor warrant the condition of the vessel. A buyer should instruct his agents, or his surveyors, to investigate such details as the buyer desires validated. This vessel is offered subject to prior sale, price change, or withdrawal without notice.
Universal Marina
Southampton, Hampshire SO317ZN
United Kingdom

subset: commoncrawl


text:
does any one know what happened to episodes 17 18 and 19 of meet the browns season 2 as it goes from episode 16 to 20
meet the browns season 2
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Aug 13, 2009 7:06PM EDT
That was just an error in the labeling. We are only up to episode 17, which hasn't aired yet. Thanks!


text:
In an exclusive interview with Yankee, Andrea Phillips, wife of Captain Richard Phillips, talks about what her life was like in Underhill, Vermont, during her husband's ordeal last April, when he was captured by Somali pirates.
Andrea Phillips maintains that their newfound celebrity hasn't changed them. "We are who we are," she says.
Click here for Audio version of Andrea Phillips interview
Yankee: When was the first time you knew something was different about Richard's trip last April?
Andrea Phillips: I really didn't think anything was different until I got the phone call Wednesday morning. It was from our neighbor Mike Willard, who lives up the road, who is also a Merchant Mariner. He called me up and said, "Andrea, what's the name of Richard's ship?" I said, "Why, what happened?" Because you don't just call up a sailor's wife and ask the name of the ship and not have something happen. Richard always told me that news from a ship is not usually good news. So when you hear something, you know it's not good. [Mike] said, "I think it was just hijacked. I'll be right up." My sister happened to have spent the night with me, and she was getting ready to leave. This was very early in the morning–I think before 7:30. And I ran out to get her, yelling, "Leah, don't go."
Y: How much had you and Richard talked about pirates in the months leading up to this?
Andrea Phillips: This was not news. I was not totally blindsided by it. As a matter of fact, it was during February; we had some friends up and we were talking about pirates, and Richard said it's not a question of if, it's when.
Y: Did you feel helpless?
Andrea Phillips: I'm not sure "helpless" is a word I would use. I'm a pretty tough cookie, so I didn't feel too helpless. I was a little scared. Everybody was trying to reassure me: "Okay, Andrea, you know the plan; they'll want the money, they'll get the money, and Richard will come home, but it takes a while. It doesn't happen within days. Sometimes it happens in months." So I was just trying to get that reassurance. Trying to reassure myself, even. They're not out for blood. Maybe they're not that nice to hostages, but they're not out there to fatally injure them. Also, knowing Richard, I just believed in him, that no matter what the situation was, he'd play it right, he'd know the right thing to do. He'd know the course to take.
I know from my brother, who has sailed with him, he's a different man on the ship. He's focused; the ship is his responsibility, and he takes it very seriously. He has a huge responsibility and takes that responsibility very seriously, as he does as a father and [as] a provider in this house. The burden is on his shoulders. You know, last year he broke his neck playing backyard football, and we talked: "What if this doesn't work out … What if I end up in a wheelchair?" He came very close to being paralyzed. He said, "What would happen if I couldn't take care of my family?" It's all about his responsibility. It was his ship, his crew, his cargo, and I just had faith in Richard as a man, as a leader.
Y: When did you find out that things had taken a turn for the worse?
Andrea Phillips: Late Wednesday morning, we started getting people coming to our door. But at this point I wasn't getting anything direct.
Y: What was your life like at this time?
Andrea Phillips: I was with my sister and our neighbor. All of a sudden there were the local TV reporters; at one point we had two cameras and five people sitting on my couch, because I have a sectional couch. We're glued to the TV, I'm still trying to call people at the company; at one point I actually sent Rich an e-mail, hoping to get something back, hoping maybe he could still get to a computer. He'd [sent] me an e-mail a few days earlier: "The pirates are getting restless." I was just hopeful, wishful thinking [that] this is not going to happen to us. Little did I know.
Y: Tell me about the moon connection between you and Richard.
Andrea Phillips: This goes back to our dating. He'd always send me at least a postcard from someplace, somewhere in the world where he'd been traveling. And he sent me one postcard that said, "I'll see you in the moon." And it became this little thing, because no matter where he was in the world, we'd still sit under one moon. And as our kids, Danny and Mariah, were young, I always wanted to keep Richard very much in their lives, because at 2 or 3 years old, out of sight, out of mind. We had pictures of Richard on the refrigerator, pictures of Dad's ship, and we'd always say good night to "Daddy's moon," because I'd always say, "Daddy's looking up and looking at you off the moon." So that really just became a symbolic thing in our family when he was away.
And the fact that all this happened under a full moon was just like wow. I'd go to bed every night, and the moon was just outside our bedroom window, so just before I pulled the shade, I could see that moon, and I sent my thoughts to Richard via the moon. I guess deep down inside, I was hoping he was thinking the same thing: "We're both under the same moon. We're in this together."
I do believe that there is a connection, there is a power up there. Because at one point for me in this whole event, I had a desperate moment when I needed to do something for Richard, and I thought if I could just get all this powerful energy and good wishes and all this positive energy to him, it would help.
Y: What did you do?
Andrea Phillips: [Easter] Sunday morning I was lying in bed, and I was just thinking to myself, "God, Richard must really be exhausted; we're going into our fifth day. I can only imagine how he felt. I thought, "I just have to do something for him." What could I do from 7500 miles away? From the other side of the world, what could I do? That's when I had this idea. We have a little saying that has sustained us during moments of family crisis, through fun times, and not-so-fun times. You would chant, "God is good"; then someone would reply, "All the time, all the time." Then the other person would repeat, "God is good." We picked it up at a Mass many years ago, and we just sort of hung onto it for ourselves.
So I thought, "If only I'd thought about this the day before," because I had the bishop of Vermont calling me, and the local churches calling, all asking what they could do. I could have had the whole state of Vermont saying, "God is good" and have everyone reply, "All the time, all the time." I thought that could just be the power I could give Richard. Something to hang onto. So after I thought, "Why didn't I think of that before?" I finally got up and asked Alison to try and reach at least the local priest.
Y: Alison?
Andrea Phillips: She was the woman sent from Maersk [the shipping company]. And she jumped out of bed. She drove to Morrisville and she got through to the priest and they did it.
Y: Somebody called you so you could hear it?
Andrea Phillips: Alison stayed for the Mass, and she called Jonathan, who is also a representative, and he got on his phone said, "Here, you have to listen to this." And we were sitting around the kitchen table listening, and as I was listening, it started to snow. Now, snow is a good thing for us up here in Vermont. To me it was a sign. I know it's kind of an unbelievable thing to believe, but to all of us in that house we knew it–hearing that, the snow. It was our little miracle. We knew it was going to be okay, and a couple of hours later we got word.
Y: Tell me about when you got the official word that Richard had been rescued.
Andrea Phillips: I had a houseful. I had my sister and two good friends. They were my pillars; they just flanked me on both sides and took control over what I could no longer control. Amber would be the one person who in [the] early morning I would confide in. I'd say, "Amber, what if this doesn't work out?" She had my weakest moments.
So people are coming and going all the time on Sunday. Richard's mother had arrived. She's a very strong, religious woman, a firm believer, and she flew up from Florida; she needed to be here. She showed up Easter Sunday morning. I'm just drained. I'm going to go up [to] my room, which is kind of my safe haven. I just want to lie down for a while. This is close to noon. Even though I'm not supposed to turn on the TV, because we made the rule: no TV, because the constant 24/7, it could drive you crazy. I turned on the television just to see a movie and figured I'd fall asleep in a few moments. And as I did that, there's a little ticker on the bottom: "Captain Phillips rescued…"
I don't think I stopped on a step. I flew down the stairs and said to Jonathan, "Find out if this is true." And he called his contacts; the company was all celebrating, and they kind of forgot to call me. They were waiting for the official word. I still don't know how it came down from out there in the ocean to here at stateside, but there were tons of phone calls from that point. [Vermont senator] Patrick Leahy called me to tell me they were dancing in the parking lot.
My first phone call–because my girlfriends are holding onto the phone–my friend Paige says, "Who is this?" And I hear her scream: "Richard is on the phone!" It was just the moment of hearing his voice.
Y: What did he say to you?
Andrea Phillips: First he said to me, "Is your husband home?" [laughs] I said, "No." Then he said, "I'll come right over." It was just a little thing Richard and I always had; he'd call me at any hour, day or night, and in that little baritone voice of his, he'd say, "Is your husband home?" I teared up. I'm tearing up even now, remembering.
Y: From that moment to when he came home, he had no idea about the media response to this. Was there any way for you to prepare him?
Andrea Phillips: I said, "Richard, you have no idea what's going on on this side of the world; it's absolutely crazy." I told him about people camped out in the yard with satellites.
Y: Why do you think the nation got so caught up?
Andrea Phillips: Well, it was everywhere in the news. You couldn't help but hear about it. And the 24/7 news is usually something bad, you know, like the Tiger Woods thing, not usually a nice outcome, or as spiriting as this was. People will say, and even Richard has a hard time with the hero thing. I say, "You could have let them take control of the ship, you could have told them where the men were; you took a chance, having this play out differently, you did the right thing, Richard." I said, "You did the right thing; you protected your ship, you protected your crew, you protected your cargo… You knew the odds were better if it was just you against them, and that's a heroic moment.
So I can see why the public felt the same way; you don't get everyday heroes. You don't hear a lot about the everyday heroes. Look at the policemen and the firemen who put their lives on the line, and you don't hear about them. And it went on for five days, and it was Easter, a religious holiday for so many in the world. It wasn't just here in the United States. It was worldwide.
Y: When did you know you had your husband back, not the world hero back?
Andrea Phillips: From the moment he got off that plane. I always had my husband, because in our house we are who we are. Even outside this house, we are who we are. I don't want to say I wish it had never happened, but I'd be fine if it hadn't. This has given us unbelievable opportunities to meet some unbelievable people [whom] we would never otherwise have [had] the opportunity to meet, and that's the best part that came out of this: some of our U.S. military people; I had dinner with Madeleine Albright, who is kind of an amazing woman to me. And everyday people like us went to the Washington Opera. We toured the Queen Mary. I was never so impressed as I was meeting some of the military wives. I had a husband who had a job, went to work, who after three or four months came home, and until this pirate thing I never thought he had a dangerous job. But you take these young military wives, and they kiss their husbands goodbye not really knowing again if it's going to be two or three months or 18 months, and are they going to make it home. I was more touched by them than I thought I should be touching their lives.
Y: When did life become more normal?
Andrea Phillips: It took a while. We were so bombarded. People wanted us to get on TV. Larry King called us personally, and Jay Leno called us personally, wanting Richard to tell his story. It took pretty much until the end of May, when it started to die down a little bit. We joked and said, "Thank God for swine flu," because that became the next media sensation.
Y: Did you have a refuge?
Andrea Phillips: I think we did. We'd go out on the lake with a boat or just being with our close friends. People said, "We didn't want to call you, didn't want to bother you." We said, "Are you kidding? Your calling us is our normal, asking us to come over for a beer." Even our closest friends felt they wanted to give us time, but they were part of our real life. That's my norm. That's part of my everyday life.
Y: Richard has said that in his life he always had this pattern: home for certain months, then away. Now he faces a mysterious future. How does that affect you?
Andrea Phillips: I'm not sure yet. Ask me if he never goes back. Rich and I get along really well. We had the routine where I wouldn't see him for a while, and that kept everything new and fresh. Even my friends would joke: "Get my husband a job where he could go away."
We're in a different phase right now, the kids are away in college, and now it's back to where it started, just the two of us. But I still do what I always do: I get up and go to work. My everyday routines are still my everyday routines. It's different at this point having him home. He's actually busier with planning events, which is odd for us, because Rich would come home and never have to do anything except fix the door handle or cut the lawn. We're not used to having Richard sit in front of the computer or on the phone. I'm not sure how it will affect us; I'm hoping that it doesn't. I don't think it will. Through all of this, I'm proud that we've maintained who we are. We haven't lost that.
Y: That's hard to do.
Andrea Phillips: He's a very grounded man, and he grounds me, and it grounds our kids. We've just stayed focused on who we are and who we've always been, and I don't want that to change, except [that] some of the opportunities to go places and meet people has been sort of wow! I sat in the Oval Office, I sat on the couch, and I couldn't help but think of all the amazing people who have passed through these doors, and I'm one of them. Not that I'm amazing–but how did I get here? Why am I sitting here? That was an absolute wow.
To read more about Andrea Phillips, her husband, and her husband's ordeal, check out our story from March, 2010 – Captain Richard Phillips and The Pirates.


text:
Amy April 1, 2014
Posted in the Chicago Forum
"...,to wit"
Since: Jun 09
Location hidden
#1 Apr 1, 2014
Dear Amy: My youngest child is in her 40s. She is kind-hearted, a giver and allows others to take advantage of her. I applaud her attitude of wanting to be helpful, but I know she often resents the person who accepts her help because she'll text me about it in a way that lets me know she's not happy. I've told her (apologies to Eleanor Roosevelt) that nobody can take advantage of her without her consent, and have encouraged her to say no if she really feels put upon or overextended.
If I react too strongly I risk alienating her (she seems to have no problem bristling at me). Her husband is also bothered by this tendency of hers but seems equally powerless to effect any change.
What also troubles me is the potential adverse effect of her behavior on my 3-year-old grandson, an only child.
She seems to want to be liked, and has many friends, but can't seem to bring herself to refuse someone a favor when asked. Do you have any suggestions? Frustrated Father
Dear Father: Your daughter is a grown woman. You (and her husband) have already tried to urge her toward change by giving her advice and pointing out the obvious.
You sound like good guys who care about her. She vents to you but then discounts your sound, logical and 100 percent correct advice.
I am going to suggest something that might be very challenging for you: It's time to back away from this problem.
The next time you get a text where she complains about being taken advantage of, you should respond by saying, "Bummer. This sounds tough!" If she further engages you by complaining about being taken advantage of, you simply say, "I'm sorry you're unhappy, honey. I wish you weren't so hard on yourself."
Your daughter already knows how to change this dynamic. Her life will be easier and more joyful if she has some positive energy left over for herself and her family. Being more careful about her commitments will also make her feel better about those times when she does choose to step forward for a friend.
If she doesn't manage to do this, her son will grow up with a mother whose generosity is always tempered by an undercurrent of dissatisfaction.
Dear Amy: After a couple of years of searching, I finally found a hairdresser who understands what I want. He gave me the greatest haircut.
However, I noticed that his tools (combs, brushes, hand mirror) were (far) less than clean. When I got home, I found many dark hair clippings on my face. I am a blonde.
How can I bring this up with him without offending? I'd really like for him to do my hair, but yuck! What should I say? Bothered
Dear Bothered: The fact that you want to spare this man's feelings rather than run screaming into the street (or post a negative review on Yelp) says what a nice, lovely and (possibly pathologically) passive person you are.
When someone is in business, he simply has to find a way to provide the kind of service that will keep clients coming back, and lead to positive referrals.
Because you are so nice, you need to think of your comments as helpful and they will be helpful.
Leave a message at the salon and ask him to call you back.
You say, "James, I want you to know that I absolutely love my haircut. You are a dream machine. I'd like to share one serious concern, however...."
How he responds to this reasonable feedback will tell you a lot about him.
If this continues to be a problem for your next visit, you will have to find another skilled cutter. This lack of basic hygiene is unacceptable.
Dear Amy: I've contemplated writing to you for advice on a family situation. But your recent suggestion that a meddlesome reader ask herself, "What does this really have to do with me?" is a good starting point for my solution.
So thank you! An Unintentional Meddler
Dear Meddler: That's the whole idea. Thank you.
"Where is Tonka?"
Since: Feb 09
Neda, stay with me! Charlie
#2 Apr 1, 2014
1 YUP not you're problem
2 Absolutely positively gross.
3 The rehash that wasnt.
"reign in blood"
Since: May 09
#3 Apr 1, 2014
1- You raised a daughter without a spine, but anyway it's her and her husband's problem
2- Gross, and isn't that some kind of health code violation?
3- No rehash? Perhaps L1 should take your advice
Since: Mar 09
#4 Apr 1, 2014
"The two baby belly, please!"
Since: Sep 09
Evanston IL
#5 Apr 1, 2014
LW1: Instead of trying to get her to say no, you need to say no to her b!tching and whining.
LW2: Won't saying thing until they get lice.
LW3: I feel cheated.
Since: Aug 08
Location hidden
#6 Apr 1, 2014
LW1: Sounds like you and her husband have tried to talk to her. So, I would drop the issue. It's really her problem, not yours.
From now one when she texts or calls to vent, Id say, I really dont want to listen to you vent Ive told you before that you need to learn to say no and you dont listen.
LW2: Find a new barber or say something to him.
"Where is Everyone?"
Since: Jul 12
Location hidden
#7 Apr 1, 2014
L1: Take Amy's advice. Your daughter is playing the martyr card. Stop making it work for her.
L2: Eww!
"An Apple a day"
Since: Jun 08
nil carborundum illegitemi
#8 Apr 1, 2014
1. You're the one who raised her.
2. Gross.
#9 Apr 1, 2014
1: I agree with all the above comments on this one. I'd like to add one thing though. I wonder whether the woman might also have something of a self-esteem issue. She seems to think the only way people will like her is if she lays down and lets them walk all over her. She has put herself into this situation; people think she will be happy to help them out whenever they ask. What she needs is therapy to find out why she allows this and to make her realize she doesn't need to be this way. For those who say this isn't the lw's problem, I can see why she's involved. Her daughter makes her involved by complaining to her. Oh, no. I don't mean to say the lw needs to help her daughter; only that the daughter brings her into it. She can't help feeling an emotional involvement. But she needs to learn how to tell her daughter to get some professional help in saying no to people and that she doesn't want to hear these complaints again because all that happens is that she gets stressed out. I've been in that situation and never had the gumption to tell the complainer to stop telling me about things I had no control over and did not have anything to do with me. I wish I had. I bet the daughter tells her mom that she's the only one she can talk and "vent" to. It probably makes the lw feel that she HAS to listen. I can only advise her to stop listening. In a way, she's enabling her daughter to continue her self-destructive behavior.
2: What Amy said.
3: Boring.
Since: Aug 08
Location hidden
#10 Apr 1, 2014
I have too, and I have told folks if they don't wish to follow my or anyone's advice then I fail to see the need to discuss the issue.
It's one thing to come to friends and family looking for advice when you are facing troubles, but it's another to refuse to follow anyone's advice and expect folks to just basically listen to you whine on and on about something that is completely within your ability to change. I just don't have the patience for the latter, and I don't like to spend my time listening to folks whine just for the sake of whining.
#11 Apr 1, 2014
LW1: The first problem is that she allows others to take advantage of her and then whines about it. The second problem is that she whines to her father and husband, and men tend (generally) to be fixers rather than listener-sympathizers. LW is a fixer. So I agree with Amy. What LW needs to do is prepare some responses that acknowledge that the daughter was heard without giving any advice. "Oh really? Uh-huh. That's unfortunate. Wow, that was rude." Etc.
LW2: My mother was a hairdresser and I used to help her clean up on Saturdays when I was growing up. Standard procedure was to NEVER use the same comb or brush on more than one customer! At the end of the day, all of the combs and brushes were soaked and then washed in a sterile solution. What LW is describing has got to be a health code violation! And LW should definitely tell him about it. Gross.
LW3: Yup!
#12 Apr 1, 2014
LW2 spoke up to that hairdresser when:
(a) she got head lice
(b) she found a hair dresser that kept the equipment much cleaner
(c) other
#13 Apr 1, 2014
LW1: Your daughter gets off on helping people. She gets off *even more*
by biching and moaning about it. She doesn't want your help--she just wants to be a whining martyr.
You can't do a thing about it. Let her whine and moan to her heart's contents, or just tell her to STFU.
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Unemployment Insurance: Survey of State Administrators and Contacts with Companies Promoting Tax Avoidance Practices
GAO-03-819T: Published: Jun 19, 2003. Publicly Released: Jun 19, 2003.
GAO appeared before Subcommittees on Oversight and Human Resources, House Committee on Ways and Means to discuss the results of our investigation of the extent to which states have found that companies manipulate state unemployment tax rates through a variety of methods in order to lower their unemployment taxes, a practice known as "SUTA dumping," and of the extent to which some consulting firms...
Compact of Free Association: An Assessment of the Amended Compacts and Related Agreements
GAO-03-890T: Published: Jun 18, 2003. Publicly Released: Jun 18, 2003.
In 1986, the United States entered into a Compact of Free Association with the Pacific Island nations of the Federated States of Micronesia, or FSM, and the Republic of the Marshall Islands, or RMI. The Compact provided about $2.1 billion in U.S. funds, supplied by the Department of the Interior, over 17 years (1987-2003) to the FSM and the RMI. These funds were intended to advance economic develo...
Military Retiree Health Benefits: Enrollment Low in Federal Employee Health Plans under DOD Demonstration
GAO-03-547: Published: Jun 6, 2003. Publicly Released: Jun 6, 2003.
Prior to 2001, military retirees who turned age 65 and became eligible for Medicare lost most of their Department of Defense (DOD) health benefits. The DOD-Federal Employees Health Benefits Program (FEHBP) demonstration was one of several demonstrations established to examine alternatives for addressing retirees' lack of Medicare supplemental coverage. The demonstration was mandated by the Strom T...
Financial Audit: Congressional Award Foundation's Fiscal Years 2002 and 2001 Financial Statements
GAO-03-737: Published: May 15, 2003. Publicly Released: May 15, 2003.
GAO audited the financial statements of the Congressional Award Foundation for fiscal years 2002 and 2001 and the related statements of activities and cash flows.We found that (1) the financial statements are presented fairly, in all material respects, in conformity with U.S. generally accepted accounting principles, (2) the Foundation had effective internal control over financial reporting (incl...
Workforce Investment Act: Issues Related to Allocation Formulas for Youth, Adults, and Dislocated Workers
GAO-03-636: Published: Apr 25, 2003. Publicly Released: Apr 25, 2003.
The Workforce Investment Act (WIA) of 1998 required states to streamline employment and training services and established three separate funding streams for serving youth, adults, and dislocated workers, for which about $3.3 billion was appropriated for fiscal year 2003. The formulas for distributing these funds to the states were left largely unchanged from those used to distribute funds under th...
Unemployment Insurance: States' Use of the 2002 Reed Act Distribution
GAO-03-496: Published: Mar 6, 2003. Publicly Released: Mar 7, 2003.
The Unemployment Insurance (UI) program, administered by the U.S. Department of Labor in partnership with states, plays a critical role in ensuring the financial security of America's workforce. In fiscal year 2002, state UI programs paid benefits totaling $50.8 billion to 10.6 million unemployed workers. In March 2002, in response to an increase in unemployment and the September 11, 2001, terrori...
Tobacco Settlement: States' Allocations of Fiscal Years 2002 and 2003 Master Settlement Agreement Payments
GAO-03-407: Published: Feb 28, 2003. Publicly Released: Feb 28, 2003.
The Master Settlement Agreement (MSA) requires four of the nation's largest tobacco companies to make annual payments to states in perpetuity as reimbursement for past health care costs related to tobacco use. The Farm Security and Rural Investment Act of 2002 requires GAO to report annually on the amount of MSA payments states receive and how they allocate these payments for the years 2002 throug...
Tobacco Settlement: States' Allocations of Phase II Funds
GAO-03-262R: Published: Dec 3, 2002. Publicly Released: Dec 3, 2002.
The Farm Security and Rural Investment Act of 2002 (the 2002 Farm Bill) required GAO to report annually on how states have used funds received under the Master Settlement Agreement and the Phase II agreement. This letter is the first in a series of reports responding to the 2002 Farm Bill requirement. Specifically, this letter provides information on (1) the amount of funds that have been distribu...
Options to Enhance the Long-term Viability of the Essential Air Service Program
GAO-02-997R: Published: Aug 30, 2002. Publicly Released: Aug 30, 2002.
Over two decades ago, Congress deregulated the airline industry, phasing out the federal government's control over domestic fares and routes served and allowing market forces to determine the price, quantity, and quality of service. Concerned that air service to some small communities would suffer in a deregulated environment, Congress established the Essential Air Service (EAS) program as part of...
Compact of Free Association: An Assessment of Current U.S. Proposals to Extend Assistance
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The United States entered into the Compact of Free Association with the Federated States of Micronesia (FSM) and the Republic of the Marshall Islands (RMI) In 1986. The Compact has provided U.S. assistance to the FSM and the RMI in the form of direct funding as well as federal services and programs. The Compact allows for migration from both countries to the United States and established U.S. defe...


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Does anyone know any good places to start with 3D in jitter?
I'm really just hunting aroung for some examples or tutorials.
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Well, someone had to post it......
Well, someone had to post it......
I speculate that there will be such a book. If you view it twice on the book shelves, you will have re-viewed it.
Seriously, I wonder if Lucasbooks would let them advance into the future and make them stormtroopers rather than clonetroopers (post-Order 66 era). It might be cool to have them interact with younger SW characters (Han, Boba, Tarkin, et al).
Too late; I already copyrighted these parodies: Rogue Juan, Rogue Won, Rogue Huan, Rogue Wan, Rogue Obi-Wan, Rouge One, Rogue Wand.
That may happen eventually. But, that is likely not going to be until book 5 or 6.
I wager 3 will be set immediately before Orger 66. And, of course, the McGuffin baby will be born.


text:
Skip to comments.Neil Patrick Harris Shares Christmas Family Photos (Disgusting Barf Alert)
Posted on 12/27/2012 7:41:17 AM PST by 3boysdad
Neil Patrick Harris, 39, enjoyed a very merry Christmas with his partner David Burtka and their 2-year-old twins Gideon and Harper. The actor shared photos of the fam via Twitter, which showed Burtka and Gideon donning Santa hats as they made breakfast, and Harper sporting a silly pair of toy glasses that belong to Mr. Potato Head. "Ms. Harper likes Mr. Potato Head's fashion sense," Harris cracked. "She is quite the looker, but I think it's a bit shortsighted."
The kids must have worn out the parents, since Burtka was also snapped taking a nap. Here is @Davidburtka enjoying his favorite, much needed, and well deserved gift, wrote Harris.
(Excerpt) Read more at omg.yahoo.com ...
Yuck. I'm disgusted to admit that I used to watch Doogie Howser.
The Russian Federation passed a law about two years ago expressly forbidding adoption by homosexuals and single people.
More like filthy Butt-Brothers!
At least they had the little boy in the suit and the little girl in the skirt. Poor kids.
Another disgusting rimmer seeking access to a young boy. Formerly confined to a mental institution, and now, allowed to take possession of children. Simply, the next item in the NAMBLA agenda to remove another roadblock to allow perverts access to other people's children. Was Sodom really a more civilized place?
And I am proud to admit I have never watched this little creep.
This is all propaganda to continue to erode the culture further down the road of hedonism.
These two will be in divorce/custody battles within 5 years when raising these two children becomes harder than the occasional phot-op.
Pray, fast do penance and live by example... it's the only way.
Harris' partner, Burtka, also "has" two children from a previous "relationship".
That is how the gay agenda is being advanced—"What' s wrong with two people loving each other? See, they' 're just like any other normal family." They ignore all of the negative aspects of the homosexual lifestyle while drawing a moral equivalency between perversion and a committee's marriage between a man and woman. Check back with these kids in 20 years
I never knew he was gay.
Some of the homosexual acts are much worse than the one you mentioned.
Reading the comments after the article, it is clear that people like you and me are the minority on this.
Ditto, Lesko!
A view not of Santa, but under Satan's rock. I pray that the souls of their two small victims can be saved.
These children will never have a mother, thanks to their two male "parents". How very, very selfish and sad.
"Neil Patrick Harris, 39, enjoyed a very merry Christmas with his partner David Burtka and their 2-year-old twins Gideon and Harper." Just 2 more screwed up adults trying to twist a religious holy day into their warped worldly and sinful view of a holiday while they also screw up two children's lives. And the rest of us are supposed to smile and nod and agree that they are totally ok and what they are doing is normal.
Does this world need Jesus? Yes, NOW!
"Neil Patrick Harris, 39, enjoyed a very merry Christmas with his partner David Burtka and their 2-year-old twins Gideon and Harper." Just 2 more screwed up adults trying to twist a religious holy day into their warped worldly and sinful view of a holiday while they also screw up two children's lives. And the rest of us are supposed to smile and nod and agree that they are totally ok and what they are doing is normal.
Does this world need Jesus? Yes, NOW!
I meant "committed" marriage. Darn Kindle Fire autocorrect!
Even Elton John admitted that he was sad that his kids wouldn't have a mother....deep down they know it's wrong, but their selfishness gets the best of them.
A committee's marriage. LOL! Polygamy's next. (Probably would've happened a long time ago, if it didn't make for good Mormon-bashing.) (And I'm all up for a good theological dismantling of Mormonism, but not because it serves my political goals.)
More actors looking for attention? THIS is news???
When that photo of the happy couple appeared on the web a few days ago, I ignored it thinking from the goofy headline that he and the partner were the twins. They look a lot alike. Everytime I see him, I also think how could I have watched Doogie. To think he was a teen heartthrob but it was the boy fans he was interested in. What is it about Hollywood that turns so many boy actors gay? Is it all the make believe and attention grabbing?
Sorry, but whenever these folks try and brainwash me into accepting their lifestyle, I always remember one important thing: THESE PEOPLE ENGAGE IN SODOMY! Nuff said!
Lucky for them the twins were born by surrogate and NOT adopted.
I can't take some of the commenters here seriously between their use of language, disinterest in situation-specific facts (not adopted kids) and various realities like the gay men who did marry women and had children naturally and ended up in divorce, etc.
This is where their lackadaisical approach to the care and feeding of the culture for future generations has come back to bite. They act like they were powerless when they simply didn't care to take up the cause. This fight was really lost in the 90s and certainly by the time W was talking about a marriage amendment (conveniently for reelection) that never got close to reality. Taking the attitude "it'll never happen" and not getting involved as more and more ground was ceded... they have no right to complain.
Just like thinking not voting for Romney last month would teach everyone a lesson, they just put themselves further and further away from being "winnable" by campaigns... it's self-marginalization which in the end guarantees they will not be listened too if they are even heard. In the final analysis they get what they truly wanted: even more things to complain about.
You voted for this? That is just messed up, LOL.
"I feel that all people should be able to participate in the Boy Scouts regardless of their sexual orientation."
- Mitt Romney, 1994, former Boy Scouts of America National Executive Board member
Romney: The Boy Scouts should admit homosexuals
After seeing what's on network television these days I'm not surprised.
For some reason I just want to smack him.
For some reason I just want to smack him.
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text:
The Disappearing Sea
Uzbekistan adventure jeep tour package to the Aral Sea
|View the route map »»
|Tour duration:
|5 days / 4 nights
|Best time to travel:
|April-May, September-October
|Nukus - Kungrad - Ustyurt Plateau - Sudochye Lake - Aral Sea - Muynak - Khodjeyli - Mizdakhan Complex -
|- Nukus - Khiva - Urgench
Guarantee Dates Of Group Tours In 2017:
|Group No. 1. 12.04 - 16.04.2017
|Group No. 2. 30.08 - 03.09.2017
The Aral Sea and the surrounding deserts and cities form a unique region in the heart of Central Asia, which, probably, has no equals anywhere in the world. Currently, the once large saltwater lake occupies one fourth of its original area, shrinking still more year after year, leaving towns and villages that once were on its shore in the centre of a white desert named after the disappearing sea, the Aralkum desert. The shrunken sea has ruined the once-robust fishing economy and left fishing trawlers stranded in sandy wastelands, leaning over as if they dropped from the air.
However, the sea is still alive and beautiful!
The jeep adventure to the Aral Sea is very interesting and adventurous, revealing the wonderful world of the Central Asian nature and unique oriental culture. The extraterrestrial landscapes of the little-studied Ustyurt Plateau, the gigantic blue mirror of the Aral Sea, once an important Central Asian weather regulator, the sorrowful ship graveyard - rusted ships frozen in the desert, the grandiose Mizdahkan necropolis, the ghost town Muynak, the hot sands of the Kyzylkum desert and the inner part of Khiva, left almost untouched since the medieval times - you will see all this for five days!
Travel to Uzbekistan and ride on jeep to see with your own eyes what happened to the Aral Sea. Find yourself amidst an absolutely different, unusual world, which will be so different from what you observe every day!
- Itinerary /
Services & Cost
Itinerary in Detail
- Useful Information
Route Map
|Day 1.
|Arrival in Nukus.
Arrival in Nukus, capital of Autonomous Republic of Karakalpakstan. Transfer to hotel and check-in. Excursion in Savitskiy museum. Leisure time. Overnight rest in hotel.
|Day 2.
|Nukus - Kungrad - Ustyurt Plateau - Sudochye Lake - Aral Sea.
Early breakfast at the hotel. At 07:00 in the morning departure from Nukus. Proceeding to Kungrad, then up to Ustyurt Plateau. Transfer to Sudochye Lake. Proceeding to Village of Urga, first Russian settlement in Khorezm and Aral Sea region, lunch en route. Then transfer to Aral Sea. Photographing canyons en route. Arrival at camp site; descent to shoreline. Dinner. Overnight in tents.
|Day 3.
|Aral Sea - Muynak - Khodjeyli - Mizdakhan Complex - Khiva.
Landscape: steppe, desert, saline land, cliffs, bottom of gone-away sea.
Breakfast in tent camp. Proceeding to Muynak along the bottom of the disappeared sea. Visiting monument to the victims of the Second World War (now a monument to the Aral Sea), which is the highest point of the town of Muynak providing a wonderful panorama of the town and the bottom of the former sea.
Visiting famous "Cemetery of Ships" in Muynak. Next visiting a museum at the House of Culture in Muynak, where you can familiarise yourselves with the works of artists F. Madgazin and R. Matevosyan, who used to depict the Aral Sea and the Amudarya River. Lunch in traditional guest house of Muynak. Proceeding to and visiting Mizdakhan Complex: Caliph Erejep, Jumart-kassab hillock, half-underground Mazlumkhan-sulu Mausoleum, Shamun-nabi Mausoleum. Transfer to Khiva. Overnight rest in hotel.
|Day 4.
Breakfast at the hotel. Guided city tour in Khiva, visiting Ichan Kala (historical inner city), Pakhlavan Mahmud Complex, Kunya-Ark Fortress, Islam Hajji Madrasah & Minaret, Tash Khauli Alakuli Khan Palace, Juma Mosque, Muhammad Amin-Khan Minaret & Madrasah, and Avesta Museum.
Overnight rest in hotel.
|Day 5.
|Khiva - Urgench. Departure.
Breakfast in hotel. Transfer to airport of Urgench. Departure.
|The cost of the tour 2017 in USD for 1 person:
|The cost of the tour for 1 person
|SGL supplement
* This tour is guaranteed and will be arranged whatever final number of persons in a group.
|Cost includes:
|Cost does not include:
|Additional Services:
We choose the most conveniently located and reputable hotels for our customers to stay at hotels 3* - very comfortable hotels providing excellent facilities and services with notable for very warm hosting and home-like atmosphere; mainly located in or near city centers.
The tour comes with the following accommodation:
|Hotels 3*
|Jipek Joli Hotel 3*
|or similar
|Orient Star Khiva Hotel 3*
|or similar
|Aral Sea
Depending on the size of a group the following means of transportation are used during the tour:
|From 1, 4 to 5 tour days
|From 2 to 3 tour days
|Group of 1-2 pers
|"Chevrolet Lacetti"
|"Toyota Land Cruiser" - 1 car
|Group of 3-7 pers
|"SsangYоng Istana"
|"Toyota Land Cruiser" - 2 cars
|Group of 8-11 pers
|"SsangYоng Istana" - 2 cars
|"Toyota Land Cruiser" - 3 cars
|Group of 12-14 pers
|"SsangYоng Istana" - 3 cars
|"Toyota Land Cruiser" - 4 cars
"Chevrolet Lacetti"
"SsangYong Istana"
"Toyota Land Cruiser"
Day 1. Arrival in Nukus.
Welcome to the capital of the Karakalpakstan Autonomous Republic - Nukus, our starting point for traveling to little-studied Ustyurt Plateau and disappearing Aral Sea.
Day 2. Nukus - Kungrad - Ustyurt Plateau - Sudochye Lake - Aral Sea.
In the morning you are going towards Ustyurt Plateau (the town Kungrad) and then, through the village Sudochye, to today's shore of the Aral Sea, the tragic fate of which has become an enormous ecological problem the whole world is concerned about.
After seeing the lake standing right on its present-day shore and having dinner you are spending the night in a tent camp pitched beforehand.
Day 3. Aral Sea - Muynak - Khodjeyli - Mizdakhan Complex - Nukus.
Saying goodbye to once the much larger sea, you are going back to Nukus, visiting the former port city Muynak on the way.
Day 4. Nukus - Khiva.
Nukus has no architectural monuments, but it is host to a world-class museum of art, which is quite intriguing. The I.V. Savitskiy State Art Museum is famous for its collection of modern Russian and Uzbek art of 1918-1935 all over the world. Stalin tried his best to eliminate all non-Soviet art of this period, and sent most of the artists to the Gulag. But Igor Savitsky, the prominent Soviet artist, 'Central Asian Tretiakov', and his collection of Russian avant-garde paintings in Nukus survived because of the city's remoteness. Now it is the world's second largest collection of Russian avant-garde paintings. During 1957-1966, Igor Savitskiy also assembled an extensive collection of Karakalpak jewelry, carpets, coins, clothing and other artifacts. He convinced the authorities of the need for a museum, and, following its establishment, was appointed its curator in 1966. After his death in 1984 Igor Savitskiy was called 'a savior of beauty'. Francois Mitterand and Albert Gore called his museum 'one of the best in the world'.
After visiting museums of Nukus you departure for Khiva - a unique and truly Orient-style city with the charming aura of the distant past. Khiva has no tall modern buildings and wide roads with much traffic. It seems time has stopped here to preserve what was built centuries ago. You are seeing a lot of magnificent Oriental architectural monuments and medieval adobe homes. All the sights of the city are compactly located within the historical Ichan-Kala old town walls. Ichan Kala is encircled by brick crenellated walls whose foundations are believed to have been laid in the 10th c. The walls themselves date back to the late 17th c. Behind them there are over 50 architectural monuments and 250 old houses; most of them date back to the 18th - 19th c.
Day 5. Khiva - Urgench. Departure.
You have made a trip to the dying Aral Sea. Your descendants may not see it "live" if it is not recovered. Witnessing the sea's disaster today teaches us quite a lesson.
Frequently Asked Questions
What nationals need visas to enter Uzbekistan?
Is it necessary to get a stay permit (temporary registration of stay) while visiting Uzbekistan?
What is Uzbekistan's currency? Where can I exchange money?
Can I use credit cards in Uzbekistan?
What is the difference between GMT and Uzbekistan time?
Can foreigners to Uzbekistan use the services of a local mobile network operator during their stays in the country? s
Can I bring alcoholic beverages into Uzbekistan?
What maximum amount of cash can I bring into Uzbekistan?
What maximum amount of cash can I take out of Uzbekistan?
Can I use a photo / video camera at the tourist sites?
What kind of clothes should I wear in Uzbekistan? Are there any clothing requirements for women in the country?
What languages do people in Uzbekistan speak?
Useful Information on Traveling in Uzbekistan
Route Map
Photos of the tour:
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All rights reserved. No part of this publication may be reproduced without written permission of the copyright owner.
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Album There Is No Greater Love
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The potential benefit of simultaneously attacking multiple targets in order to improve therapeutic outcomes has become increasingly clear. This is illustrated in the field of opioid analgesics, where the co- administration of a mu opioid receptor (MOR) agonist with a delta opioid receptor (DOR) antagonist retains the MOR-mediated analgesia but with reduced negative side effects, such as the development of tolerance and dependence, features that limit the clinical use of opioid analgesics. Clinically, it would be preferred to administer a single bifunctional drug containing both opioid receptor actions: MOR agonism to promote analgesia along with DOR antagonism to prevent MOR tolerance and dependence development during chronic administration. We propose to develop such compounds by extending our very promising initial studies that have led to both peptide and non-peptide ligands displaying the desired MOR agonist/DOR antagonist profile and which are active after intraperitoneal administration. We will simultaneously elaborate and improve both peptide and non-peptide series. For the peptide series, our focus will be on increasing potency and MOR efficacy and on improving bioavailability, the latter primarily through glycosylation. For the non-peptide compounds, we will pursue three related peptidomimetic series with the major aims of equalizing MOR and DOR affinity and increasing metabolic stability. A panel of pharmacological and pharmacokinetic assays will be used to evaluate new compounds and to select those best suited for more extensive in vivo analysis. As always, our design of new compounds will be driven by our ligand-receptor structural models which we have successfully demonstrated to be highly valuable for structure-based design.
Opioid drugs such as morphine are the primary treatment for severe pain, however development of tolerance to and dependence on these drugs limits their usefulness. Evidence exists that the desired actions of opioids can be separated from the undesired side effects by simultaneously targeting two different types of opioid receptors. Our goal is to develop single, bifunctional agents that achieve this and thus have potential as safer opioid analgesics.
|Anand, Jessica P; Porter-Barrus, Vanessa R; Waldschmidt, Helen V et al. (2014) Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues. Biopolymers 102:107-14
|Mosberg, Henry I; Yeomans, Larisa; Anand, Jessica P et al. (2014) Development of a bioavailable ? opioid receptor (MOPr) agonist, ? opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. J Med Chem 57:3148-53
|Kumar, Vinod; Ridzwan, Irna E; Grivas, Konstantinos et al. (2014) Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. J Med Chem 57:4049-57
|Pogozheva, Irina D; Mosberg, Henry I; Lomize, Andrei L (2014) Life at the border: adaptation of proteins to anisotropic membrane environment. Protein Sci 23:1165-96
|Bender, Aaron M; Clark, Mary J; Agius, Michael P et al. (2014) Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity ? opioid receptor (MOR) agonist/? opioid receptor (DOR) antagonist ligands. Bioorg Med Chem Lett 24:548-51
|Pogozheva, Irina D; Tristram-Nagle, Stephanie; Mosberg, Henry I et al. (2013) Structural adaptations of proteins to different biological membranes. Biochim Biophys Acta 1828:2592-608
|Mosberg, Henry I; Yeomans, Larisa; Harland, Aubrie A et al. (2013) Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy ýý opioid receptor (MOR) agonist/ýý opioid receptor (DOR) antagonist ligands. J Med Chem 56:2139-49
|Lomize, Mikhail A; Pogozheva, Irina D; Joo, Hyeon et al. (2012) OPM database and PPM web server: resources for positioning of proteins in membranes. Nucleic Acids Res 40:D370-6
|Lomize, Andrei L; Pogozheva, Irina D; Mosberg, Henry I (2011) Anisotropic solvent model of the lipid bilayer. 1. Parameterization of long-range electrostatics and first solvation shell effects. J Chem Inf Model 51:918-29
|Lomize, Andrei L; Pogozheva, Irina D; Mosberg, Henry I (2011) Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranes. J Chem Inf Model 51:930-46
Showing the most recent 10 out of 75 publications


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This project received 20 bids from talented freelancers with an average bid price of $254 USD.Get free quotes for a project like this
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At design level all completed. 2 tier straight forward product levels, eg, Select the Brand, all products are listed under each category. Stand alone inventory. Payment gateway VISA/Mastercard to be completed.
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The long-term objective of this work is to understand the molecular basis by which cells are polarized. Polarity is a fundamental property of cells that is required for proper development as well as adult physiology. For example, during development cell fate determinants are polarized in dividing cells as a mechanism for generating cell type diversity and the loss of cell polarity is a hallmark of many disease states, including cancer. For spatially and temporally precise establishment of cell polarity to occur, cellular signals must be interpreted and ultimately coupled to the segregation of the relevant cellular components. In diverse cell types, polarity is controlled by the evolutionarily conserved Par complex consisting of Bazooka (Baz;aka Par-3), Par-6, and atypical Protein Kinase C (aPKC). It has recently become clear that aPKC activity is the primary output of the Par complex. In this grant we seek to answer three fundamental aspects of aPKC-how it is targeted to specific cellular sites, how its activity is regulated, and how phosphorylation of substrates regulate their localization. Understanding the molecular events that lead to the coupled recruitment and activation of the Par complex will yield new insight into cell polarity.
Many cells in our body, such as skin cells that provide a physical barrier to the environment, are polarized and loss of polarity is a hallmark of many diseases, including cancer. In this work, we are investigating a set of three proteins, known as the Par complex, that regulate cellular polarities required for proper development and adult physiology. As the loss of polarity is associated with human disease, improving our understanding of the molecules that control this process will contribute to our knowledge of the mechanisms of disease states.
|Graybill, Chiharu; Prehoda, Kenneth E (2014) Ordered multisite phosphorylation of lethal giant larvae by atypical protein kinase C. Biochemistry 53:4931-7
|Mauser, Jonathon F; Prehoda, Kenneth E (2012) Inscuteable regulates the Pins-Mud spindle orientation pathway. PLoS One 7:e29611
|Graybill, Chiharu; Wee, Brett; Atwood, Scott X et al. (2012) Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement. J Biol Chem 287:21003-11
|Wee, Brett; Johnston, Christopher A; Prehoda, Kenneth E et al. (2011) Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation. J Cell Biol 195:369-76
|Johnston, Christopher A; Whitney, Dustin S; Volkman, Brian F et al. (2011) Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. Proc Natl Acad Sci U S A 108:E973-8
|Smith, Nicholas R; Prehoda, Kenneth E (2011) Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pins. Mol Cell 43:540-9
|Prehoda, Kenneth E; Bowerman, Bruce (2010) Cell polarity: keeping worms LeGaL. Curr Biol 20:R646-8
|Segalen, Marion; Johnston, Christopher A; Martin, Charlotte A et al. (2010) The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish. Dev Cell 19:740-52
|Ricketson, Derek; Johnston, Christopher A; Prehoda, Kenneth E (2010) Multiple tail domain interactions stabilize nonmuscle myosin II bipolar filaments. Proc Natl Acad Sci U S A 107:20964-9
|Cabernard, Clemens; Prehoda, Kenneth E; Doe, Chris Q (2010) A spindle-independent cleavage furrow positioning pathway. Nature 467:91-4
Showing the most recent 10 out of 21 publications