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Lake Tai
1958 Kirschner Rd, Kelowna, British Columbia, Canada, V1Y 4N6
Chinese restaurant serving veggie food and using different kinds of soymeat; note that faux meats might not all be vegan (check). Sample items include sweet and sour veggiemeat, spicy vegbeef with black pepper and veggies, plus loose leaf teas, bubble tea, and more. Open Mon-Fri 11:00am-9:00pm, Sat-Sun 12:30am-9:00pm.
Category: Vegan-friendly, Chinese, Take-out, Taiwanese
Reviews (30)First Review by NicolaKnits
Not Vegan - Edit
I recently called Lake Tai to confirm it was a 100% vegan restaurant after seeing on several review websites that the restaurant was listed as "Vegetarian" (not "Vegan"), and that Happy Cow said "note that faux meats might not all be vegan (check)". I wondered if something had changed as years ago, having been drawn in by the reviews stating it was all vegan, we had asked the owner if everything was vegan, and she had told us it was.
I called and asked if any of their veggie meats had whey and she said, "Ye-.. No, no". I asked if any of her dishes had whey in them and she said no - it's vegan. I reiterated to be sure, asking if it was all vegan; she said yes. I then asked if someone with a dairy allergy could eat at Lake Tai and she said, in what sounded like an angry tone, "...maybe you should eat somewhere else". I started to explain my reason for asking (to let her know about the Happy Cow page that said it was vegetarian, not vegan) but she hung up while I was talking.
To clarify, and to hear her response, I called back to tell her about the Happy Cow page. I asked, "Is there any dairy or eggs in the dishes?" She said "Vegetarian is vegetarian". I asked, "Is the restaurant vegan or vegetarian?" and she replied, "Vegetarian". I thanked her and hung up.
We have eaten at Lake Tai many times over the years, enjoyed most of the food and had very friendly and prompt service from the same person I spoke with above, but now we feel deceived and will no longer be eating there.
Please carefully read the description on Happy Cow and read the sign on the restaurant - it says "Lake Tai VEGETARIAN Restaurant".
Consistently incredible vegan food - Edit
We have eaten at Lake Tai as a family for over ten years. The lovely Rose always has a warm smile, treats us like family. The food is consistenly prepared to perfection, never been disappointed in all those years. The menu is extensive and anyone can find something to love.
Pros: Excellent Value, Friendly Staff, Great Food, relaxing atmosphere
best vegan in kelowna - Edit
I'm not sure why this place is not listed vegan? I talked to the owner recently and she assured me it is 100% vegan!
Anyway....we have been eating here for over 10 years and it is always amazing!! Fast service, awesome food, and the best vegan donuts in the world (free with each meal)!
Amazing Taiwanese food, and very friendly service. - Edit
We visit Lake Tai every time we are in Kelowna. The food is unreal and the owners are really sweet. The food comes out FAST and everything is always really good. The donuts at the end are always gobbled up, even though we are so full.
Pros: Very tasty, Friendly staff, Affordable
Delicious food - Edit
I love this restaurant. We go at least once or twice when we come into town.
The food is delicious our favourite is lemon steak. The service is always fast and the lady who serves us is always so friendly. This restaurant has the most friendly staff of any restaurant we have been to. The price is great and the portions are good size.
The little pineapple donut at the end of the meal is so good.
Pros: Food, Fast friendly service, cost
Wouldn't eat here again - Edit
Overpriced for the quality of food....the curry has a weird texture as does the meatless beef! Unfortunately, it was a bad takeout experience for me. As a vegan, I've tasted much better meat alternatives. Couldn't even finish the curry dish.
Cons: Texture is off, Overpriced
I adore Lake Tai! - Edit
Vegan (and some vegetarian) Taiwanese food? Yes! It took way too long for me to visit Lake Tai and when I finally did my tastebuds were extremely pleased! I had never had Taiwanese food before but this is very delicious. I also love how there's sooo many options and the prices are quite reasonable, with amazing service! The lady who has served me every time is very kind and sweet.
At the end of the meal they serve these vegan donut things, which are amazing.
I wish the space and the look of the menu were a bit more modern and it's in a strange location, so often I just do takeout. Other than that, I highly recommend visiting Lake Tai!
Pros: Delicious and yummy, Large menu, Fantastic Service
Cons: Very simple and casual, not modern, Location
Delicious Vegan Food - Edit
There is a nice atmosphere and friendly staff in this vegan restaurant that has food origins from Taiwan and not China as posted. It is very delicious food with a really huge variety of dishes and appies to choose from in their menu. The food is also very unique and it is vegan fine dining at it's best. Many dishes contain too much sugar/salt/oil to be considered health food. The main protein is also soya bean unfortunately. They are however MSG free, and it is much healthier food than any Chinese food buffet. I would highly recommend dining at this restaurant to anyone which is why they get a 5/5.
Updated from previous review on Sunday October 20, 2013
Pros: No MSG, Delicious Food, 100% vegan, no worries
Cons: High Sugar/Fat/Salt
Great choices - Edit
This was the first time we have been here as we were visiting from out of town. Definitely will come again. So many options and the veggie meats are made in house. More than filling and great service. Family run and feel like you're a regular.
WONDERFUL HIDDEN GEM - Edit
This sweet little restaurant is hidden away in a mostly industrial area, surrounded by an auto-detailing shop. However, once you find it, what a wonderful gem of a restaurant. You are greeted as if a family friend, and the service is fast and friendly, with wonderful suggestions by the owner. The menu is Taiwanese-Chinese vegetarian, with many items made of meat analogues that totally replicate those items familiar to carnivores from "traditional" Chinese restaurants. The meal for 2 had 3 entre items and a bowl of (brown) rice for each of us. Defiitely on my list of must-visit places the next time I am in Kelowna.
Pros: Friendly service, Excellent menu, Tasty food
Cons: Rather hard to find
Amazing! - Edit
This was one of the best restaurants I've ever been too!! Highly recommend!
Pros: Amazing food, Nice staff, Excellent price
My Favorite Vegetarian Restaurant - Edit
I've been going to Lake Tai forever and I know the family quite well. I love everything on the menu. This place is a sanctuary for me. Rose is a true friend to her customers and provides outstanding service. Have a chat with her if it's not busy =) Her husband sometimes comes out for a smile & wave, but he's usually just focused on doing his thing... Cooking up some of the best vegetarian restaurant food in Western Canada! He was once a personal chef for the king of Taiwan, and the quality of every dish is ensured. Note that this is not Thai food - it's Taiwanese (very similar to Chinese, with some overlap from Chinese like "Sweet & Sour Veggie Meat", "Hot & Sour Soup" and "Ma Po Tofu"). Satisfaction guaranteed! You'll be back!
Pros: Quality in every dish served, Dedicated & caring service, Free simple appetizer & dessert
Cons: There is only one Lake Tai
NOT Vegan! :( - Edit
I'm not sure how strict of a vegan everyone is who is reviewing this, but Lake Tai's "fake meats" contain whey protein, which is most definitely NOT vegan. This is unfortunate, because I know Lake Tai boasts that they are 100% vegan, but upon further investigation... they are not. Very frustrating. Good tofu, still, but please be warned that this is not actually a fully vegan establishment, but simply vegetarian.
1 Response
27 May 2014 -
How do you know this? I've gone there many times and have asked several times if it's vegan.
If this is true, how sad!
Amazing little hidden gem! - Edit
Great old school style Asian cuisine done Vegan. My non Veg husband salivated over each dish! While I prefer a little less sauce and a little less oil (read deep fried wontons with sweet and sour sauce), it's a delicious treat..... Incredibly good choice for carnivores who can still get their "fix" without grossing out the Veg dining company.
Pros: everything is vegan, tasty, well priced
Cons: saucy, lots of deep fried options, not enough veggies
Delicious! - Edit
An excellent hole in the whole. Very friendly and helpful owner/server. She confirmed everything is vegan on the menu even though it only mentions vegetarian.
We picked the special Lake Tai coconut curry which is wonderful, and spiced right. We had asked for medium spiced, which in some places is still bland, but this is really what I call medium spiced. The portion are very generous and there was enough food for leftovers.
We tried a number of dishes but the curry was the best in our opinion. Their mini chinese doughnuts were delicious. We went back the next day to buy some more!
Pros: All vegan, Tons of choice
um, yum! - Edit
Wanted to go to Lake Tai for a couple of years, and finally made it in today as I passed through Kelowna. Yummy! Had hot & sour soup, fragrant crispy lemon steak, and tofu, broc, and sugar snap peas in a spicy brown sauce, served on a sizzling plate. Everything was delicious! Lake Tai serves quality food for good value. We left stuffed. I also ordered a taro bubble tea to go - first time I've had one in eons. The woman who served us was warm, very nice, and extremely helpful.
We'll be eating at Lake Tai next time we pass through Kelowna, that's
certain - so happy there's a fully vegan restaurant within the Okanagan.
Pros: Great food, Inexpensive, Excellent server
Great Food and one of a kind - Edit
We enjoyed a fabulous meal at Lake Tai last week. It was freshly prepared and very tasty. The ingredients and seasoning were authentic, and there is no MSG! This is the only purely vegetarian (in fact, vegan) restaurant that we have found here. What an oasis. We will definitely be back.
Pros: Authentic ingredients, Completely veg, Compassionate owner
Cons: Street location isn't exactly charming
Amazing! - Edit
So yummy! The owners know us and we don't even go in super often. All of the food we've had is amazing!
Pros: So many options, All vegan! , No contamination worry!
Fantastic, I'm a happy Customer - Edit
Food was beautiful and filling. Staff was kind and caring. Please support this place as their are not any Vegan places in Kelowna. As a raw foodie, it was a great compromise to have a big plate of steamed veggies. My parents and wife loved all the other dishes too.
I love this place! - Edit
From the warm welcome to the great service to the delicious vegan Taiwanese food, Lake Tai is a huge favorite! Some of our faves are Japanese rolls, curried hot plate and fried rice. The stewed soup is also delicious on a cold day. Sweet and sour veggie meat, oolong noodles, and spring rolls are all so good.
Updated from previous review on Tuesday December 18, 2012
Pros: delicious food, amazing service, friendly atmosphere
Cons: would love more healthy options
Not great - Edit
I really wanted to like this restaurant. Maybe my expectations were too high. However, I found the fake meat to be gelatinous, fatty, and bland. The BBQ appetizer seemed suspiciously like scrambled eggs with sauce. I also ordered the satay curry... but it was just mushy broccoli, cauliflower, and blobs of something fatty and unrecognizable. I felt embarrassed, as I didn't want to insult the staff by not eating it. The lady working there was really nice.
I've never written a negative review for a vegetarian restaurant before, as I really appreciate the effort. However, the food here was not good.
Pros: vegetarian
Cons: food isn't very good
Finally Back! - Edit
Last year, I was sad to hear that Lake Tai (previously on Pandosy) had to close to make room for the SOPA development. This week, I was excited to hear that it reopened in January 2012 on Kirschner Road. The location is good, very convenient, lots of parking and bright, friendly dining area. The food is the same and as good as ever, really being the only 100% vegan option in town. Prices are low ... for example, if you chose the Menu for Two, you walk out of there with a full tummy and only $30 less in your wallet (for two). The owners are friendly and the service is very fast. A great alternative to fast food elsewhere!
Pros: Excellent food, Friendly owners, Prices
New location, same yummy veg food - Edit
Lake Tai is at it's new location on Kirshner! My husband and I were happy to see the return of this restaurant. The food is always freshly prepared and delicious. Our favorite dishes are: F3 the fried rice noodle, D2 stir fried vegetables and D1 black pepper veggie beef. The vegetable dishes are loaded with vegetables in a light sauce allowing you to taste the fresh vegetables. The black pepper veggie beef is flavorful and not too spicy. Both family and friends that have tried this dish say that it reminds them of pepper steak and they love this dish.
My husband and I are vegetarians and haven't had meat in over 10 years but every "meat" dish that we have had here is flavorful in a light sauce. The vegetable and noodle dishes are amazing as they are fresh, yummy and the portion sizes are large.
You don't have to be a vegetarian to enjoy the food at this restaurant.
Pros: Delicious food, Good selection, Friendly service
Nice place. - Edit
So far, my favourite restaurant on the BC mainland. The wonton soup is a bit bland, but other than that all the food (and the tea) is excellent. The fried rice is the best (vegan or otherwise) that I've ever had, omnivore mother agreed. Friendly and very fast service.
I went at non-busy times and didn't have a problem, however it is a fairly small restaurant. If you're planning on going at suppertime or on the weekend, it may be a good idea to phone ahead, not sure how full they get.
Pros: great food, great service, large menu
Yum... - Edit
I passed Lake Tai on the way to my hotel and made a mental note to check it out. It was great...really fresh and fast and wonderful flavours. It was great to find a place that served fresh vegan food amidst all the burger joints. The bean curd skin dishes (black bean or honey) are amazing! I'll be back next time I'm in Kelowna.
Pros: friendly staff, fast service, good value
I love Lake Tai - Edit
My boyfriend and I discovered Lake Tai one night when I was getting frustrated that there are no veg restaurants in our town. We found Lake Tai online and drove all the way to Kelowna just to eat there. We weren't disappointed!
We love to split the meal for two and add an appetizer. It's a lot of food and a lot of variety for a relatively small price. The food is delicious and we keep going back.
Pros: Large Menu, Delicious Food
Cons: Some of the food looks weird!
Best Vegan Thai Food ever!! - Edit
My family and I LOVE this restaurant!! There is not any other 100% Vegan restaurants in our area, so being vegans we appreciate this tremendously! My mother is not a vegan or vegetarian, but still loves this restaurant, so that says something in itself. They have a huge assortment of dishes and the service is always wonderful. It is by far my favourite restaurant and I would recommend anyone go here. The restaurant is totally 100% vegan and the prices are great!
Pros: excellent food, awesome service, great prices
Far from the best - Edit
My Vegan friend and I visited Kelowna for a few days, and having read the comments on this site, decided to make the long walk to eat here. We arrived and were happy that the menu had pictures, however a listing of the ingredients would have been helpful. The Japanese Cones were amazing, we both really enjoyed them, and although my friend is not a fan of Sushi, she enjoyed it. Next we had a mildly spicy fake beef dish, and a tofu and vegatable hot plate. The tofu vegetable hotplate was okay,but we found it to be too much sauce. The fake meat I disliked entirely, and my friend described it as simialr to granola. Overall, I would say that you are better to go to the DT restaurants and order veggie burgers or fajitas, or go to the local cafes for their wraps. If you do brave this little restaurant I would not recommend the fake meat, however the tofu was okay, just go light on the sauce. Or, order a BUNCH of the Japanese rolls...YUMMY
Pros: Vegan
Cons: Too Much Sauce
finally a vegan restaurant in kelowna! - Edit
tasty food, large menu, great service.
Love the Lake Tai - Edit
I love the Lake Tai. In a city full of fast-food outlets and steak restaurants, it's great to have a completely vegan place where we can go for special occasions. Our family of five eats a big lunch there for about $100. It's a small restaurant with personal service (owner-operated), freshly cooked food and a pleasant atmosphere.
Pros: excellent food, generous portions
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Lot 839: Grandpa and Me by Norman Rockwell
October Modern and Contemporary Fine Art Sale
by Great Dane Auctions
20 October 2016
Philadelphia, PA, USALive Auction
Past Lot
Looking for the realised and estimated price?
- Grandpa and Me
- Norman Rockwell
- Original lithograph in color on paper
- 1978
- E82 from the rare limited edition of 100
- Hand signed and numbered by the artist
- 30 x 23.75 x 0
Condition Report: Mint
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subset: commoncrawl


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CHANGE of pace, change of venue, change of second-row personnel and, supposedly, a change of tone. England moved from the leisurely atmosphere of the Gold Coast resort to the high-rise hotel life of central Brisbane yesterday and although Clive Woodward, the head coach, talked about "stepping up a gear" and taking on a "whole new mindset", his brow utterly failed to furrow and he seemed more relaxed than on any day for at least three weeks.
At long last, the tournament has arrived at what is called the "business end" and it may be something to do with the run-out


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Evaluation of docking results is one of the most important problems for virtual screening and in silico drug design. Modern approaches for the identification of active compounds in a large data set of docked molecules use energy scoring functions. One of the general and most significant limitations of these methods relates to inaccurate binding energy estimation, which results in false scoring of docked compounds. Automatic analysis of poses using self-organizing maps (AuPosSOM) represents an alternative approach for the evaluation of docking results based on the clustering of compounds by the similarity of their contacts with the receptor. A scoring function was developed for the identification of the active compounds in the AuPosSOM clustered dataset. In addition, the AuPosSOM efficiency for the clustering of compounds and the identification of key contacts considered as important for its activity, were also improved. Benchmark tests for several targets revealed that together with the developed scoring function, AuPosSOM represents a good alternative to the energy-based scoring functions for the evaluation of docking results.
The modeling of protein ligand interactions by computational molecular docking is a widely used approach for virtual screening. One of the most challenging problems with this method lies in the identification of active compounds in large sets of docked molecules. Typically, ligand-binding affinity is estimated by scoring functions. Ideally, scoring functions should be able to select the correct pose for each molecule and arrange ligands in accordance with their affinity to the receptor. In practice however, estimation of binding energy is a very difficult task. Several studies have shown that although docking programs are usually able to provide poses with correct ligand conformation, the relevant estimation of binding affinity for the right pose remains a great challenge.1–6 Another problem posed by the scoring function approach, is the strong dependency of scoring efficiency on a particular data set.5,7 Some authors3 have suggested making trial runs for the target of interest using ligand sets with known activity in order to define the best suitable scoring functions. Various machine learning methods7–9 have been used for the construction of target dependent docking scoring functions. Consensus scoring methods, which offer promising prospects to solve the problem, take into account predictions from several scoring functions.10,11 However, if all scoring functions fail to estimate the binding affinity, the consensus will also yield poor results.12 Thus, the development of new approaches for a more efficient evaluation of docking results remains a pressing issue.
In the past decade, several methods based on binding mode contact analysis have been developed for the characterization of protein ligand interactions in docking experiments.13,14 This approach takes advantage of the fact that in the majority of cases, structurally similar ligands present high conservation of the binding modes to their receptor.15 The key idea of this method uses the similarity of binding modes to identify native like poses to select active compounds. The pharmacogram approach16 utilizes similarity to the pharmacophore grid to score docking poses and compounds. The grid is constructed using the best poses out of several best-docked compounds top-ranked by conventional scoring functions. The template-based method uses knowledge of the key receptor ligand interactions to focus docking searches on poses similar to the template.17,18 The template is generated from an experimental protein ligand complex structure. This method can be implemented as an additional term to the scoring function, and has been shown to improve results of docking evaluation. Analogously, the structure interaction fingerprint method13 uses ligands from cocrystal structures as a reference for the native contact set. Interactions found between a ligand and a receptor are presented as fingerprints which are constructed for all poses of all docked molecules and scored in accordance with the similarity to the reference as measured by the Tanimoto coefficient. The structure interaction fingerprint method has been shown to provide results superior to the conventional scoring function approach. However, the mandatory requirement of reference data for the structure interaction fingerprint method raises important limitations of this promising approach. The concept of contact fingerprint comparison was successfully applied in the maximum common binding mode approach for the selection of the native like poses of active molecules.14 Poses of docked ligands were scored according to the similarity of their binding modes and poses, the highest rank selected as native like conformations. The method performed better than individual scoring functions and did not require a reference structure.
Automatic analysis of poses using self-organizing maps (AuPosSOM)19 represents a new approach that uses the concept of contact fingerprint similarity for virtual screening. Kohonen's self-organizing maps (SOM) method20 is applied for the unsupervised clustering of docked compounds,21 ligands and decoys then arranged in the hierarchal tree with respect to the similarity of binding modes. The problem of the correct pose selection is overcome by the use of statistical analysis of the contact information over all poses of the ligand. The AuPosSOM approach has been shown to provide good results for the tested data sets, clustering a significant number of active compounds separately from the decoys.19 However, preliminary knowledge of activity for at least a few active compounds is required for the selection of the correct cluster.
In this study, we developed a scoring function for the identification of the active compounds in the AuPosSOM clustered dataset without prior knowledge of the compounds' activity. Additionally, we improved the efficiency of the clustering and key contact data analysis. Benchmark tests for several targets revealed that together with the newly developed scoring function, AuPosSOM represents a good alternative to energy-based scoring functions for the evaluation of docking results. Our method does not require reference data such as the crystal structure of the protein ligand complex.
Datasets for the benchmarking tests of AuPosSOM were obtained from the DUD 2.0 database (DUD – A Directory of Useful Decoys; Shoichet Laboratory, University of California, San Francisco, CA, USA).22 The DUD database contains ligands and decoys for 40 protein targets with the approximate active compounds:decoys ratio 1:36. Decoys are physicochemically similar but topologically dissimilar to the active ligands. Because of these properties, DUD is considered to be one of the most challenging datasets for virtual screening benchmarking tests currently available. Datasets for the following nine targets with different polar and geometric properties of the binding sites were selected for the evaluation of the AuPosSOM clustering efficiency: CDK2 (active compounds:decoys ratio 50:1779), COX1 (25:849), DHFR (201:3318), HIV protease (53:1885), HIV RT (40:1437), HSP90 (24:860), progesterone receptor (PR; 27:967), thrombin (65:2292), and trypsin (44:1544). Proteins with metal containing binding sites were not considered, as currently available docking programs do not efficiently treat interactions of ligands with metals. Corresponding protein structures for docking and ligands for definition of the docking search space were also retrieved from the DUD 2.0 database.
Protein molecules for docking were prepared using the Sybylx1.2 (SYBYL, Tripos International, St Louis, MO)23 and Chimera1.524 software programs. Mol2 files of the targets provided by DUD did not contain water molecules. Explicit hydrogens were added and AMBER-ff99SB25,26 charges were calculated for the receptor molecules. Ligand molecules provided by DUD were already assigned with the atom's partial charges. This was calculated using the quantum mechanical approach for unbound ligands. Docking was performed by Surflex-Dock 2.0 from the Sybyl 1.223 package using mol2 files of targets and ligands. Protomol was generated with default parameters (threshold of 0.50 and bloat equal to 0). Each docking experiment was repeated 20 times yielding 20 docked poses. Ligand energy minimization prior to docking and all-atom-in-pocket minimization after docking was performed. Virtual screening with docking was performed on one Linux PC (quadricore Intel 2.66 GHz, 2 GB RAM). Four C Score23 scoring functions were utilized for the evaluation of the docking results using the conventional energy scoring approach: ChemScore, PMF, G-score and D-score.
Identification of the protein ligand contact set that represents the difference in the binding modes between decoys and active compounds is a key point for successful clustering. Five types of atom selections were tested:
Contacts were selected in such a way that one atom belonged to the protein and another one to the ligand. Contact search was accomplished for all datasets. Atom selection and search for the contacts between ligands and receptors were performed using modified "findclash" and "findhbond" modules of Chimera 1.5.24
AuPosSOM clustering was made for all nine datasets using all types of contact selection. Fingerprints were presented as one dimensional vectors and were generated as previously described.19 Clustering was made using the unsupervised learning SOM algorithm implemented in AuPosSOM for each type of contact separately. Optimized parameters for clustering were obtained from Bouvier et al.19 The 4×5 SOM matrix was utilized providing that the resulting tree of clusters of compounds could contain up to 20 leaves.
A filtering step was added in order to increase the efficiency of the SOM procedure and to facilitate calculations. The final clustering algorithm included three steps: (1) first round of clustering, (2) contact filtering, and (3) second round of clustering. As the SOM algorithm uses random value for the generation of the initial map, calculations were repeated ten times to obtain representative results. Two filters were then introduced. The first filter removed contacts that were very weakly populated and could be considered as noise. This facilitates calculation and simplifies manual contact analysis of the clustering results without influencing the SOM efficiency. A contact was considered as weak if its average population over all the leaves of the tree was less than 0.02. This population is caused by non systematic contacts of ligands with receptors and can be treated as noise. The second filter was constructed to remove contacts with large average population in all leaves. This procedure simplifies the contact matrix and increases the efficiency of the SOM clustering. Mean values for the contact population were calculated for each leaf of the tree and the average value of the obtained mean values was calculated. A contact was considered as equally populated and removed from the contact matrix if the following condition was true for all leaves of the tree:
where Icontact mean leaf is the contact population's mean value for the leaf, Itree is the contact population value averaged over mean values for all leaves, and α = 0 and β = 3.2 are empirically optimized constants.
An empirical scoring function was developed for the identification of the leaves containing active compounds. In accordance with the contact activity relationship (CAR) concept,19 it was proposed that active compounds should form more selective and highly populated contacts than decoys, as their affinity to the target is higher. In order to calculate scores for the leaves, Icontact mean leaf values were calculated for each contact over each leaf. Each contact was weighted (Wcontact leaf) for each leaf separately with respect to the following rules:
where I is the number of the contact and N is the total number of contacts in the vector.
The efficiency of AuPosSOM was evaluated in two ways:
Two dimensional heat maps were used for visualization of the clustered vectors. This representation of the clustered vector matrix provides clear information about contact population distribution and allows for easily defined key contacts for the binding of the compounds clustered in the same leaf.
Results of the docking for nine DUD datasets were evaluated using AuPosSOM clustering followed by scoring with the scoring function developed in this study. Comparison of ROC curves for the AuPosSOM and four conventional scoring functions revealed that for eight out of nine targets, the results yielded by AuPosSOM are as good as (or better than) the results obtained using the energy scoring approach (Figure 1 and Table 1). Tested datasets can be divided into three groups based on clustering efficiency and ROC curves for scoring: DHFR, thrombin and trypsin (group 1) for which AuPosSOM was very efficient; progesterone receptor, HIV RT and HIV protease (group 2) for which AuPosSOM provided reasonable results; and HSP90, CDK2 and COX1 (group 3) for which AuPosSOM scoring did not identify a significant number of active compounds with clustering efficiency less than that for group 2.
AuPosSOM ROC curves for the group 1 datasets demonstrated a high level of active compound identification. The results for DHFR and thrombin datasets are better than those of the best energy scoring (PMF function for DHFR and ChemScore for thrombin). Only ChemScore is comparable to AuPosSOM scoring for the trypsin dataset. The group 2 datasets were challenging for both clustering and energy-scoring approaches. For the progesterone receptor dataset AuPosSOM scoring ROC curves are better than those of three scoring functions. HB contact selection and filtered coulomb contacts provided clustering scores that were as good as the best scoring functions for HIV protease. Energy scoring did not yield meaningful results for the HIV RT dataset. AuPosSOM scoring for coulomb contact selection was more efficient than energy function scoring. Both AuPosSOM and energy scoring approaches did not provide ROC plots that were significantly different from the random one for CDK2 and COX1 datasets. For the HSP90 dataset, AuPosSOM scoring was worse than three energy scoring functions, while energy scoring was not very efficient.
Coulomb and HB contact selections were the most efficient and provided the highest level of clustering of active compounds (Table 2). More than 80% of the active compounds were clustered in one leaf for the best contact selection for the targets from group 1. The best result was obtained for the DHFR coulomb contact dataset, with almost 90% of active compounds clustered in one leaf and only 5% of decoys from all compounds in the leaf. Clustering for progesterone receptor, HIV RT and HIV protease provided worse enrichment for the active compounds. The percentage of the active compounds in the best leaf from all compounds in the leaf was relatively low, between 14.5% to 18.5% for the best contact set. At the same time, more than 47% of the active compounds were clustered together for the best contact sets. HB selection gave the best results for progesterone receptor and the coulomb contact set was the best for HIV RT and HIV protease. HSP90, CDK2 and COX1 datasets appeared to be the most difficult to evaluate. A high number of decoys were clustered in the best leaves for CDK2 and COX1 targets. The evaluation of the HSP90 dataset was better for energy scoring functions compared to the AuPosSOM scoring, clustering yielding reasonable results for this target. The absence of populated contacts made it possible to cluster 55.2% of the active compounds in one leaf for the filtered matrix of coulomb contact selection. They formed 9% of the compounds of the cluster.
Clustering can be characterized by the ROC plots created using information about distances between the leaves in the tree to add points in the ROC space. Distance information points out the similarity of the clusters, the best leaf of the tree used as the starting point. These ROC plots provide results superior to the ones derived from AuPosSOM scoring (Figure S5).
The observed set of contacts represents the properties of the protein binding site and ligands. Thus, the probability of obtaining a good clustering for a particular contact selection correlates with the properties of the receptor binding site. For example, COX1 bears a hydrophobic active site buried inside the protein globe. Only four atoms participate in the formation of HB with the compounds from the DUD dataset (Figure 2). These contacts are present in all leaves, providing a highly similar geometry of the polar fragment organization in the docked conformations for both active compounds and decoys, and a low chance for good clustering. The hydrophobic contact set (Figure S4) represents a significantly more heterogeneous contact population distribution, implying that hydrophobic contacts should play a key role in the activity, although there is still not enough difference in contact vectors for successful identification of the active compounds. The progesterone receptor's binding site also bears a small number of HB (6 atoms form HB contacts with the average population over all active compounds higher than 0.05 (Figure 2)), while the dispersion of populations for the contacts between the leaves is much higher than that for the COX1 HB contact set. 53% of the active compounds form two very specific contacts, which makes their clustering in one leaf possible. Trypsin contains a polar active site27–29 indicating that the analysis of the HB and coulomb contacts should give good results. Indeed, five atoms form very intense and specific HB with the active compounds (the average population over all active compounds higher than 0.8 (Figure 2)). Notably, more than 93% of the active compounds were clustered in one leaf.
The number of decoys clustered with the active compounds is relatively high, exceeding 50% for even the best targets (except DHFR). This problem can be attributed to the similarity of the contacts between the active compounds and some decoys, for example as is the case for the thrombin and trypsin HB contact sets. Another reason for this observation is the size of the SOM matrix that allows for the maximum of 20 clusters. This may not be enough for large datasets; although it was demonstrated that increasing the matrix size does not lead to better clustering.16,18 This problem may be fixed by constructing the subtree for the best leaf.
Construction of the subtree for the thrombin coulomb contact set led to the identification of 49% of the active compounds without decoys (Figure 3). The trypsin coulomb contact clustering defined two families of active compounds with different contact fingerprints, yielding two leaves containing 69% and 25% of all active compounds respectively (Figure 4A). The subtree for vectors of these two leaves provided excellent clustering, with six leaves containing 94% of all active compounds without decoys (Figure 4A and B). A high rate of similarity between the contacts for decoys and active compounds meant that the coulomb contact subtree represented a difficult dataset for scoring. Meanwhile, the highest score was assigned to the best leaf, and 63% of all active compounds were identified without decoys (Figure 4B). In order to increase the efficiency of the ligands selection, the coulomb contact subtree was implemented for mapping of the HB and lipophilic type 2 contact vectors. As a result, vectors for HB, coulomb, and hydrophobic contacts were clustered in one tree, providing convenient data organization for scoring cross validation and comparison of the different types of contacts (Figure 4A). However, HB and lipophilic type 2 contacts of decoys and ligands differed significantly, as the selection of the compounds to the subtree was based on the similarity between coulomb contacts. This provided efficient scoring for these contact selections and a corresponding improvement of the ROC curves (Figure 4B). HB scoring selected four leaves with 86% of the active compounds without decoys. Lipophilic contacts scoring yielded a selection of 68% of ligands without decoys, 94% of the active compounds identified together with 0.3% of the decoys.
In contrast to coulomb contact sets, the construction of subtrees for the HB contact sets of trypsin and thrombin did not result in an increase in clustering quality. This is due to the high similarity of HB contacts between active compounds and decoys clustered in the best leaf. In addition, the subtree for the DHFR HB data set yielded efficient clustering (data not shown).
Five types of contact selection were utilized. One of the main goals of this procedure was to probe different types of contacts to find the types of contacts that yielded the best clustering of active compounds. Two types of contacts were described: polar contacts (selections 1 and 2), and lipophilic contacts (selections 3 and 4). All atom contact selection was made as a control for the presence of the specific contacts that were not included in other selections. Atom selection by partial charge was used for selections 2 and 3. This is a robust and flexible way to probe contacts between specific atoms. An additional reason for using this approach was to take into account the electrostatic properties of the molecules, as atoms with the highest partial charges of opposite signs could be expected to come into contact in a space. Atoms with partial charges close to zero could also be expected to group together as a result of hydrophobic interactions.
The best results were obtained for the HB and coulomb contact selections. Lipophilic and all contact evaluation of the interactions appeared to be not specific enough for efficient clustering. The coulomb contact selection yielded the best results for five targets (DHFR, thrombin, HIV RT, HIV protease, COX1, and HSP90) providing the highest enrichment of the best leaf (Table 2). HB was better for PR, CDK2 and trypsin. The better clustering for the trypsin HB contact set can be explained by the fact that coulomb contacts represent more detailed information about binding by providing clustering of active compounds in two leaves. Selections 3 and 4 for lipophilic contacts yielded approximately the same results (Table 2). Even for targets with hydrophobic binding sites, better clustering than polar selections was not achieved.
The technique for filtering the contacts that are present in all leaves helps to simplify vectors for the SOM analysis and can increase its efficiency. Additionally, removing equally populated contacts can improve scoring and significantly simplifies visual identification of key contacts on the heat maps. The technique is especially useful when the number of equally populated contacts is much higher than the number of specific contacts. In this case high-populated non selective contacts mask the difference in binding modes and decrease the efficiency of AuPosSOM. Removing these contacts may significantly improve clustering. An example of this is the HIV protease coulomb contact dataset (Figure 5 and Table 1). For good datasets, like DHFR, where a few very specific contacts are present for active compounds and where the number of contacts that are common for all leaves is not higher than the number of specific contacts, filtering decreases the number of decoys in the best leaf (Table 1). However, this may also slightly decrease the number of active compounds. Removing weakly populated contacts does not influence clustering or scoring, but simultaneously simplifies the analysis of the heat maps.
AuPosSOM scoring function provided good evaluation of the clustering, the scoring consistent with the distribution of the active compounds in the tree for eight datasets. AuPosSOM scoring for the clustered HB contact matrixes without filtering is shown in Figure 6. Scoring function defined the best leaves for eight datasets unambiguously. Heat maps for the corresponding matrixes are displayed in Figure 2. Careful analysis of the contacts revealed that clustering of the best leaf active compounds for the group 1 and progesterone receptor datasets is governed by the presence of selective contacts. For HIV RT, HIV protease, CDK2, and COX1 datasets, the best leaf ligands' clustering is mainly provided by highly populated contacts. These two types of contacts make a strong positive contribution to scoring, yielding the highest scores for the leaves containing active compounds. The HSP dataset was the most difficult for scoring, as active compounds did not contain remarkably populated HB contacts. This corresponds to a close to zero value of the score for the best leaf.
Scoring values provide information about dispersion of the contact populations over the leaves. A negative scoring value indicates that the leaf contains mainly equally populated contacts. The absence of positive scores for all leaves of the tree implies that compounds of the dataset do not exhibit significant differences in the contact sets, and that the probability of efficient clustering is low.
We have developed a scoring function for the identification of the active compounds in the AuPosSOM clustered dataset. The results demonstrate that the AuPosSOM contact analysis followed by scoring of the compounds using the scoring function developed can provide a high level of selection for active compounds. For three datasets, the clustering scoring method gave better ROC curves than the best energy scoring functions and for five datasets the efficiency was approximately the same. Thus, this new approach represents an alternative to the energy-based scoring functions and can be more efficient than conventional techniques. Construction of subtrees for the best leaves and cross validation of scoring for different types of contacts proved to be a powerful method for increasing the level of identification of active compounds.
Analysis of the results revealed that clustering efficiency depends strongly on the data set and contact selection. AuPosSOM ROC curves for the filtered coulomb contact selection were better or comparable to those of the conventional scoring functions for eight out of nine datasets, indicating that the clustering approach is more robust than the energy-based one. Score values may be used to estimate the probability for efficient clustering, while information regarding the receptor binding site's properties can also be helpful.
The clustering was efficient in cases where the difference between contact sets of active compounds and decoys was significant, while the presence of well-populated contacts for active compounds was additionally required for successful scoring. These conditions were satisfied for HB and coulomb contact selections for eight tested datasets. The only exception was the HSP90 target, for which active compounds were characterized by the absence of well-populated, selective HB and coulomb contacts. This may point out the need to search for new types of contact selection. At the same time, energy scoring did not provide good results for this target either. Altogether, these data may indicate that docking failed for HSP90.
Various contact selections were tested for clustering. They characterized two types of contacts: polar and lipophilic. Additionally, all contact selections were probed. Polar contact data sets provided significantly better clustering than lipophilic and all contact selections. Even for hydrophobic active sites, like that of COX-1, lipophilic datasets were not superior. The selection of the atoms by their partial charges appeared to be an efficient method for the evaluation of coulomb interactions, providing the best results for most of the targets. All atom selections failed as a result of masking of specific contacts by a high number of non specific interactions.
An important difference in the AuPosSOM clustering and scoring approach in comparison with the energy scoring approach, is that it takes information about the contacts of all poses of the docked compound simultaneously. This allows for average docking imperfections and avoids errors related to the best pose search. A weakness of this approach might be its inability to evaluate the results correctly when the number of poses with correct contact sets is low. In this setting, the energy scoring-based approach may be used to extract the right pose by energy estimation. Remarkably, in accordance with our results, the scoring functions used in the tests were not efficient for most of the difficult targets. Another important idea is that the contact-based approach does not take the conformation of the pose into consideration. This approach greatly simplifies the analysis, as the main requirement for successful clustering is the presence of a unique set of contacts for active compounds rather than the correct overall conformation of the pose. The latter is often hard to achieve, especially for ligands that were not obtained from the receptor's crystal structure used for docking.
Fingerprint heat map data representation allows for the identification of key contacts for groups of compounds, as well as easy comparison of contact sets for compounds of different structural families. The examples of the implementation of the AuPosSOM software demonstrate the possibility of its utilization for pharmacophore characterization and its applicability to CAR analysis. The analysis of a contact set of compounds with known activity can directly provide the requirements needed for a search of compounds with the highest binding affinity. The information about key contacts and their populations may also be utilized as a filter for screening large libraries of ligands. One of the recent uses of AuPosSOM clustering is the integrative computational protocol for the discovery of the inhibitors of the Helicobacter pylori nickel response regulator.30
It is necessary to emphasize that the DUD database contains ligands and decoys that have similar physicochemical properties, and thus represents challenging objects for CAR analysis. For AuPosSOM contact-based clustering and scoring, the search for active compounds in libraries containing compounds with highly diverse properties, should be a much easier problem to manage than DUD datasets. Active compounds have a high affinity for the receptor and are expected to form the largest number of high-populated contacts corresponding to the decoys. Consequently, clusters with these vectors will be assigned the highest scores. Additionally, these clusters can be defined by the visual analysis of the heat maps. Good efficiency of clustering for libraries of compounds with highly diverse properties was demonstrated in our previous publication for Thrombin and HIV Protease targets.19
Version 2.0 of AuPosSOM is available online (http://www.aupossom.com). Further improvement of clustering and scoring efficiency is in progress.
ROC curves for the Coulomb contact set of protease. (A) Vectors were not filtered, (B) Vectors were filtered.
Notes: Different charges were tested for the contact search. ROC curves obtained using preliminary knowledge of the best leaf position in the tree and distances between the leaves in the tree.
ROC curves for the coulomb contact sets of protease (A and B) and thrombin (C and D). (A and C) Vectors were not filtered, (B and D) Vectors were filtered.
Notes: Different distances were tested for the contact search. ROC curves were obtained using preliminary knowledge of the best leaf position in the tree and distances between the leaves in the tree.
ROC curves for the selection 4 contact set of thrombin. (A) Vectors were not filtered, (B) Vectors were filtered.
Notes: Different distances were tested for the contact search. ROC curves were obtained using preliminary knowledge of the best leaf position in the tree and distances between the leaves in the tree.
Data for the selection 4 contact set of COX1. (A) Fingerprint before filtering, (B) Fingerprint after filtering, (C) ROC curves.
Note: ROC curves were obtained using preliminary knowledge of the best leaf position in the tree and distances between the leaves in the tree.
ROC curves for the AuPosSOM clustering and conventional scoring functions results.
Notes: ROC curves for AuPosSOM were obtained using preliminary knowledge of the best leaf position in the tree and distances between the leaves in the tree. ROC curves for the lipophilic contacts 2 selection is not shown as the results are close to those of lipophilic contacts 1. ROC curves for the clustering of the filtered contact matrixes are presented for AuPosSOM.
AuPosSOM scoring.
Notes: ROC curves for ten runs of the AuPosSOM clustering. HB contact dataset. Filled circles: clustering without filtering, blank circles: clustering with filtering.
AuPosSOM scoring.
Notes: ROC curves for ten runs of the AuPosSOM clustering. Coulomb contact dataset. Filled circles: clustering without filtering, blank circles: clustering with filtering.
We thank the Language Centre at Paris Descartes University, for English corrections in this manuscript.
The authors report no conflict of interest in this work.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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The first feature film under the recently formed Australia India Film Fund (AIFF), Unindian released the first look of the upcoming film. The Australia India Film Fund was established in the year 2013 and is a first of its kind initiative between the two countries. The body was established to fund those Australian films which have Indian themes so as to reach out to a broader audience base. Unindian is a romantic comedy film with renowned cricketer Brett Lee and Brick Lane famed actress Tannishtha Chatterjee in lead roles.
Unindian is written by Thushy Saathu and directed by Anupam Sharma. The film is about Meera (played by Tannishtha), an Australian women of Indian origin. She lives in Sydney. She is a divorcee and a single mother. She follows her dreams instead of following the dreams set up by her parents for her. She falls in love with an Australian man Will (played by Brett Lee). This is a scandalous issue. What happens next is what the film deals with.
Presented by Devendra Gupta and Yateender Gupta, the film is produced jointly by Anupam Sharma and Lisa Duff. The executive producer is Chandru Tolani.


text:
Midwestern State University Makes List of Top 10 Best Universities in Texas
New study shows that Midwestern State University in Wichita Falls has a lot to offer at a reasonable price tag.
New study shows that Midwestern State University in Wichita Falls has a lot to offer at a reasonable price tag.
The MSU Football team put all the tackling drills to use when when they caught and dog-piled onto a thief until WFPD could arrive on the scene.
A Political Science assistant professor has filed suit against Midwestern State University, saying he was denied promotion due to his race.
The historic Zales Building in downtown Wichita Falls will get an artsy update in the near future
Students and parents interested in financial aid possibilities should plan to attend the final event for the year
When asked a series of political and pop culture questions, how did these students do?
A 21 year-old Wichita Falls woman accepts plea deal in the 2014 shooting death of a former Midwestern State University student.
Lemonade Day comes to Wichita Falls this Saturday.
Possible bomb threat on MSU campus
Dr. Louis J. Rodriguez, former MSU president, has died at 81
This week will be a celebration of Caribbean culture, music, food, and more as Caribfest kicks off on the Midwestern State University campus
Boys ages 6-17 can learn basketball skills from Midwestern State coaches and players this week.


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Early Christian Thought in its Jewish Context
Edited by John M. G. Barclay John Philip McMurdo Sweet
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Early Christian Thought in its Jewish Context by John M. G. Barclay
Book DescriptionThe theme of this volume is that of continuity and discontinuity between early Christianity and its Jewish parent. The formation of Christian thought in the context of its Jewish beginnings is the focus of much debate and controversy. These essays cover the historical and social background of Palestine and the Diaspora; the main components of the New Testament canon and early non-canonical writings, examining their relationship to the Jewish tradition; and central themes including monotheism and Christology, apocalyptism, ethics, and martyrdom. The concise treatments, with their helpful bibliographies, by an international team of experts will be of interest and value to teachers and undergraduate students of the New Testament and Christian origins. It puts an alternative complexion on the relationship between Judaism and the convictions of the early Christians, and will stimulate discussion.
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Book DetailsISBN: 9780521462853
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Pages: 316
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Publisher: Cambridge University Press
Publish Date: 28-Jun-1996
Country of Publication: United Kingdom
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Books By Author John M. G. Barclay
Divine and Human Agency in Paul and His Cultural Environment, Paperback (March 2008)
Aims to re-examine Paul within contemporary Jewish debate on the topic of divine grace and its relation to human agency, attuned to the significant theological issues he raises without imposing upon him the frameworks developed in later Christian thought.
Early Christian Thought in Its Jewish Context, Paperback (November 2007)
Examines the continuity between early Christianity and Judaism - the focus of much controversy.
Negotiating Diaspora, Paperback (May 2004)» View all books by John M. G. Barclay
The study of the ancient Jewish Diaspora is developing in exciting new directions on the basis of fresh archaeological material and
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Originally Posted by 7pntail
COOL!! THANKS FOR THE PICS. Nice looking pitt! Never thought I would say that in a lifetime. That is quite a "buck" you have made for training.
That buck has been around the block many times. There are a number of tooth marks in it and there have been several dogs that have used it. I never, when I built it, would have guessed a Chessie or a Golden would ever use it. Let alone a Terrier (or mixed terrier) breed!
"Determining and applying the criteria for when and when not to use correction is the essence of the art of dog training. I make a distinction between a mistake and a lack of effort." - Mike Lardy - Volume I "After Collar Conditioning"
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Indiana Jones and the Kingdom of the Crystal Skull
Dark Horse Comics, May 22, 2008 - Juvenile Fiction - 96 pages
The intrepid Doctor Henry Jones Jr. is back in his biggest adventure yet! This time, the world-renowned archeologist finds himself caught in a series of events that all point to a discovery unlike any other. But will his rivals in pursuit of this priceless treasure seize his quarry from right under his nose? Not if he, and a few unexpected companions, have anything to say about it! The thrill and the humor, the action and the romance, the hat and the whip - everything you love about Indy is here: this is a tale sure to please long time fans as well as foster a whole generation of new ones!
What people are saying - Write a review
MovieUser Review - artistswife - Overstock.com
Good service and price on the order. It is a really fun escape movie. Harrison Ford still has the character down and Cate Blanchette makes a good bad guy. The Crystal Skull completes our Indiana Jones collection and brings closure to the series. Read full review
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Indiana Jones and the Kingdom of the Crystal Skull
John Jackson Miller,George Lucas,David Koepp,Luke Ross
No preview available - 2008


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But fear not - there is plenty to explore...Shop all Ronix Shop sale Ronix
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Prices lag LI home sales
While sales are up and prices remain flat, one of the most surprising statistics is the steadily shrinking inventory of homes for sale.


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Jefersson_lasombra is listening to: Abertura Dragon Ball Budokai 3 (em Portugues) by Renato Garcia
Serena is listening to: Carry On by Fun.
putona is listening to: Where Were You by Michael Cash
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ACT tourism authorities will try to use viral marketing in a new $1 million campaign to promote Canberra, offering 500 people a free holiday in return for spruiking the city through social media.
Australian Capital Tourism's "human brochure" campaign, which began yesterday, is trying to collect "first-hand accounts of our nation's capital". It is looking for people who are active on social media, and will give them – and a friend or their family – a free weekend in Canberra.


text:
Thanks for letting me know you like it. I'm quite fond of it's colour
and intend to watch it closely to see if it is good enough for
introduction. In it's first year it had acceptable plant and stalk
habits. Nice large well formed flower. Consistent colour. flower bud
is black up until it opens.
Chuck Chapman
Re: Re; Broken colour # 8
Posted by: "Francelle"
Mon Jan 5, 2009 11:31 am (PST)
Chuck, your 06-B33-1-cc is the first of all these broken
color pictures that
I have really liked. To my eyes, broken color irises usually look
This one has clear colors and sharply defined splashes. Have you
thought of
introducing it?
Francelle Edwards Glendale, AZ Zone 9


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This is our studio site. Among other things, we run two businesses:
Field Notes Brand and The Deck Network. Visit them please.
Fresh Signals
From "Biggest Eaters of Seafood" to "Most Airports Per Capita" here's the WSJ's The World Cup of Everything Else. -sd.06.13.14 #
A post from the daily flow of linkage called Fresh Signals, at Coudal.com.


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UGG® Women's Delizah Casual Shoes
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"Mek Some Noise"University of California Press 2007; US$ 29.95
"Mek Some Noise" , Timothy Rommen?s ethnographic study of Trinidadian gospel music, engages the multiple musical styles circulating in the nation?s Full Gospel community and illustrates the carefully negotiated and contested spaces that they occupy in relationship to questions of identity. By exploring gospelypso, jamoo ("Jehovah?s music"), gospel... more...
'Nationes', 'Gentes' und die Musik im MittelalterDe Gruyter 2014; US$ 148.56
The notion that ideas and judgments about music are based on culturally specific and national frames of reference and ideologies was not invented in the modern era. Taking an interdisciplinary perspective, this volume examines the role played by notions of communities such as Germani , Itali , and Franci (Germanic, Italian, and French)... more...
In Your Mercy, Lord, You Called MeThe Edwin Mellen Press 2010; US$ 59.95
In this study Dr. Nancy C. James analyzes the symbolism in Josiah Conder's poetic hymn, the expression of his beliefs and the notion of prevenient theology that motivated Conder. more...
100 Best Albums Of All TimeHardie Grant Books 2013; Not Available
The 100 Best Albums of all Time announces and elaborates on the best albums of released since music gave birth to rock and roll. From the opening snare shot that was heard around the world on Like a Rolling Stone from Bob Dylans stunning Highway 61 Revisited , through the pioneering genius of the Beatles best work, across the... more...
101 Amazing Marilyn Manson FactsAndrews UK 2013; US$ 2.99
Are you the world's biggest Marilyn Manson fan? Or do you want to know everything there is to know about the controversial frontman?If so, then this is the book for you! Contained within are 101 amazing facts about everything, from how Marilyn got started in the music business to his personal life, awards he has won, unusual objects he is said... more...
2006De Gruyter 2006; US$ 328.02
K�rschners Musiker-Handbuch (K�rschner's German Music Handbook), recording some 12,000 living music professionals from the world of serious music, comprises composers, conductors, soloists, singers and music professors who work predominantly within the German-language area. Individual entries contain biographical particulars, a contact... more...
The 80s Pop Music Quiz BookAndrews UK 2012; US$ 2.99
How well do you know your 80's Pop Music? This Quiz book will test even the most avid fan, with questions that span the 80's bands and songs! Test yourself and your friends with this 80's Pop Music Quiz Book. more...
Accompanied VoicesBoydell & Brewer 2015; US$ 27.69
Accompanied Voices is a unique book: not only is it a highly readable anthology of some of the most memorable and accessible international writing about classical music, but also a moving commentary by one set of practising artists on the work of another. more...
The Advancement of Music in Enlightenment EnglandBoydell & Brewer 2014; US$ 99.00
Casts new and valuable light on English musical history and on Enlightenment culture more generally. more...
The Advent ProjectUniversity of California Press 2000; US$ 70.00
In his final accomplishment of an extraordinarily distinguished career, James W. McKinnon considers the musical practices of the early Church in this incisive examination of the history of Christian chant from the years a.d. 200 to 800. The result is an important book that is certain to have a long-lasting impact on musicology, religious studies, and... more...


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Oct 10, 2013, 12.28 PM | Source: CNBC-TV18
Uday Kotak, MD, Kotak Mahindra Bank in the next few months he expects the long-term rat on government securities to be between 8-9 percent and short-term rates between 8-8.5 percent.
Uday Kotak (more)
Executive Vice-Chairman & MD, Kotak Mahindra Bank |
In the next few months, he expects the long-term rat on government securities to be between 8-9 percent and short-term rates between 8-8.5 percent.
Also read: Pull out the champagne; current account deficit trounced
Below is the verbatim transcript of his interview to Manasvi Gehlani of CNBC-TV18.
Q: What is your view on MSF rate cut?
A: There is not much room for us to drop rates because we did not increase rates against a 300 basis points increase either.
Q: Your view on the overall interest outlook for the company?
A: My view is that right now the short-term rates are higher than the long-term rates. We will see the reverse. I see the long-term rates on the government securities between 8 and 9 percent and the short-term rates between 8-8.5 percent in the next few months.
Q: One question on the IMF looking a little more negative or rather pessimistic on the GDP numbers that we are expecting, your sense on that?
A: My sense on GDP growth is assuming it was normal that is business as usual based on the first half GDP growth looks like 4-4.5 percent. There are two positives to that, one is agriculture coming out of a good monsoon, it could surprise us positively. Number two, in the second half of this year there is going to be significant election spending, which can add to growth. So, both these can bring it up a little bit but without these two factors 4-4.5 is where I see growth.
According to Ashwani Gujral of ashwanigujral.com,
Describing the 24 PSU banks as "the 70 percent pro
Speaking to CNBC-TV18, Shanti Ekambaram said that
Kotak Mahindra Bank, in a recent intimation to the
Chandan Taparia of Anand Rathi Securities recommen
Contact No.*
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text:
Pressler and Pressler, LLP has been a practicing law firm in New Jersey since 1930. As an established member of the retail collections community, we have grown exponentially in size and volume over the past decade. Now operating throughout the State of New York as well, we process a significant number of lawsuits annually between the two states.
Pressler & Pressler maintains two separate offices, with our main buildings headquartered in Parsippany, NJ. With over 300 employees and 18 attorneys, we continue to seek new members to join the firm in expectation of our ever-increasing caseload. We recover millions of dollars annually for our clients and as a result of our success, are constantly in receipt of new work from our clients. Our clients include the state of New Jersey, a variety of major credit card companies, hospitals, and hundreds of other clients.
We encourage professionals to seek employment with our firm without previous legal experience as we have a thorough in-house training program for incoming employees. By offering hands-on legal experience, we provide a background for our employees to gain admittance into law school, graduate school, or advance within the firm at an accelerated rate.


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Update 04/18/2016
This pic was originally inspired by the stories of victims of torture during a dark military period my country went through. Mainly women.
That someone just recalled that fact yesterday during the impeachment vote as if it was something to praise leaves me dumbfounded and disgusted and therefore I'm adding this text.
PS: I don't want or care to discuss my political ideas or whatever, but some actions cannot be accepted.


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Find a Steakhouse
Another one of my experiments with siri while in Las Vegas for PubCon 2011 was to see how good the function was for locating popular searches like steakhouses and nightclubs.
While standing directly in front of BOA Steakhouse inside the Caesars Palace Forum Shops I asked siri to "find a steakhouse."
Looking at the reply we can see siri found a number of steak restaurants nearby, 20 of them were listed as fairly close to me.
Unfortunately, BOA wasn't listed as one of the 20 results.
There are three steak restaurants inside the forum shops (BOA, Joe's and Palms), and only Joe's got listed.
A "steakhouse" search via Google maps returned all three, in positions A., B., and C.
Siri has a significant amount of improvements to be made.
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Uploaded on November 15, 2011


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window blinds, conservatory blinds, pleated blinds
There's no need to drill holes to fit Perfect Fit Pleated blinds –
they come with their own frame that fits snugly and easily to your UPVC
window and door frame around the edge of the glass. These blinds are
ideal for the sides of conservatories, tilt and turn windows and most
uPVC replacement windows.
Print this page
Slim 20mm pleats with unobtrusive slim Aluminium top and bottom rails available in a choice of either white or Brown. To raise and lower the blinds, cords are used. Please choose if you require the controls on the Left or Right. All our Free Hanging Pleated Blinds are supplied with a choice of brackets for either Recess or Face fixings.
Our Roller blinds can be raised and lowered by a Sidewinder made of white plastic bobble chain. Please choose if you require the Sidewinder control on the Left or Right. You
can choose a pull for the Roller Blind as an option. Please note the
pull is purely for decorative purposes, and not to be used to raise and
lower the Roller Blind.
Our Deluxe Roman Blinds are raised and lowered with a white beaded sidewinder Please choose if you require the Sidewinder on the Left or Right. All our Deluxe Roman Blinds are fully lined, and have a With Care Instruction label. Some of our fabrics are available with a choice of Blackout linning. Selected Roman Blinds can be Dry Cleaned. Please ensure all fibre rods and cords are removed beforehand.
Our Vertical Blinds are controlled by cords and can be made to either
draw to the Left, Right or the bunch of the lourves can be Split to both
sides. The tilt control - to angle the lourves - is controlled by a plastic chain. The Deluxe Wide Bodied Vertical Blind head rail is supplied in White with colour co-ordinated visible components. The track dimensions are: 45mm wide x 25mm deep. Brown
track is supplied using our Slim Line Vertical Blind head rail.
Our Wood weave Blinds have a Roman Style operation with a cord lock. All blinds have a wooden head rail and are supplied with a matching valance that measures a depth of 12cm.
Our Venetian Blinds can be tilted, raised and lowered by seperate controls. To raise and lower the blinds, cords are used. Tilting of all our Venetian Blinds, is by a wand. Please choose if your require the controls on the Left or Right. The Head rail for our 15mm, 25mm and 35mm Venetian Blinds measures 27mm wide x 19mm deep. The 50mm Venetian Blind Head rail is 38mm wide x 28mm deep. All our Aluminium Venetian Blinds are supplied with standard swivel brackets for either Recess or face fixings
The Perfect Fit frame means that
the blind becomes an integral part of your window and helps prevents
light from entering in down the sides, enhancing your privacy and also
improving insulation. Perfect Fit venetians do an excellent job of
reducing heat in a conservatory during summer and in winter help with
improving insulation. Venetian blinds are a great choice as the
slats can be tilted to allow as much or as little light into your home
as you wish.
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text:
What's the soil like in Wichita Falls? I know it's zone 7 and runs 10
degrees colder there than in Dallas. Are they dealing w/ black gumbo
clay or something easier?
Pam Evans
Kemp, TX
zone 8A
----- Original Message -----
From: cathy carpenter
Sent: 8/8/2004 7:00:37 PM
To: firstname.lastname@example.com
Subject: Re: [CHAT] Art in Garden talk - now vines
> Speaking of vines (back from escorting my daughter and granddaughter to
> Wichita Falls, TX) any one have some ideas for vines and foundation
> plants that might do well in that area? They are in quarters at
> Sheppard AFB and do not want to have their yard stand out as the worst
> in the housing area. (My "plant challenged" offspring asked for my
> help!) As is typical in "rental" property, the yard has suffered from
> years of neglect.
> Cathy
> On Monday, August 2, 2004, at 07:40 PM, Donna wrote:
> > I have so many gates and fences here it looks like Starlock 13 here.
> > Long story, but besides the outer fence the last twelve feet also have
> > another fence. (If it were up to me- it would not exist) Anyways, I did
> > hang a large sign on that gate, built these fake tree type things for
> > the trumpet vines to cover- I am still waiting for the vines to grow to
> > cover them... Everyone says they take over the world, well they may,
> > just not here :( .....may cash in the whole idea soon.
> >
> > Donna
> ---------------------------------------------------------------------
> Support hort.net -- join the hort.net fund drive!
> http://www.hort.net/funds/
Support hort.net -- join the hort.net fund drive!


text:
I am curious Theresa.... just how many things did you find to buy that didn't include something from other countries.
----- Original Message ----
AS I was happily drinking a bottle of apple juice at work yesterday I
happened to catch the label that indicated it was made from apple
concentrate from about 8 different countries- including China. I
seriously considered tossing the rest of it. I'm just a bit concerned
that we don't really know what is going into the food chain anymore.
And I realize that this could be a problem from a number of countries,
but given China's current track record, I'm more concerned the usual
about it. So, I'm off to the store (think I'll make the trek to the
CoOp or Whole Foods) and see if I can find food made in the US and
Canada for now.
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE GARDENCHAT


text:
LDAP-Interface for Google App Engine
This project received 4 bids from talented freelancers with an average bid price of €190 EUR.Get free quotes for a project like this
Project Budget€30 - €250 EUR
Total Bids4
Project Description
I create And deployed Appengine with google: https://xxxxxxxx.appspot.com. At another Website Student have Username And password with [url removed, login to view] job is allows this student With Help of Ldap-Interface to login with their old Username And password in my Site:>[url removed, login to view]
for more Details contact [url removed, login to view] just for freelancer with Experiance with ldap-Authentikation ?you dont Need App Engine Experiance for the job
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Store Details
At the Casselberry, FL Home Depot, we're pleased to have you shop with us! You can find us near the Casselberry Police Department, off of SR 436 and Hwy. 17-92. When you get here you'll quickly see why we're much more than a hardware store. We hope to be your go-to experts for all things home improvement.
We have experts in paint, lighting, building and more. Need advice on deck boards? We're sure to have an associate who can help you get the information you need.
Not only do we love helping with home improvement projects, but we also stay involved in the community through supporting organizations like Casselberry Veterans Inc. At the Casselberry Home Depot, we love our customers.
Shop the best, forget the rest!
Your Casselberry Store Team


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Digital Fiber Laser Marking Head - Chinaprice: contact company for price
Cooling good
Prevent dust
Work light, observe the working state
1.Instrustion of 25 Pin of Marking head
Power shield
X Power shield
Y Power shield
2.Instrustion of led of Marking head.
Red on: Just on or Projection.
Green on: Working Well.
Company Contact:
- Posted By: Beijing viasho Technology Co.,Ltd
- Phone: 8601057282272
- Address: Binbin Group Dingfuhuangzhuang Huilongguan Changpi, Beijing, China
- Email:
- Website: http://www.viasho.com
Published date: May 18, 2013 -
- Business Description: Beijing Viasho Technology Co., Ltd., founded in 2002 by Dr. Liu, is a
Hi tech company, which specializes in the R&D and manufacture of laser
scanning galvanometer and Diode Pumped Solid State (DPSS) lasers and
related laser products.
Beijing Viasho Technology Co., Ltd. can also provide special service for non standard requests. Whether your requirement in on our product list or not, we will modify or produce an entirely new design to satisfy your needs or application. Don't hesitate to contact our engineers and sales person for assistance with your applications. We are certain that we can provide a product to fulfill your needs.
Related listings
Jct Reactor TankGeneral Manufacturing - Foshan JCT Machinery Co., Ltd - China - May 20, 2016 - contact company for price
1. Simple Description JCT reactor tank: 1) . Different capacity design from 50L to 50, 000L. stirred mixing reactor 2) . Made of stainless steel 304/ 316L, or other material ( decide by client) . 3) . Have jacket and coil- pipe style. stirred mixing ...
Selling All Models Of Pto Hydraulic PumpsGeneral Manufacturing - A&S Hydraulic Co., Ltd - China - May 17, 2016 - contact company for price
A& S Hydraulic Co. , Ltd supplies all models of PTO Hydraulic Pumps: PTO Hydraulic Pump HC- PTO- 1A PTO Hydraulic Pump HC- PTO- 2A PTO Hydraulic Pump HC- PTO- 3A PTO Hydraulic Pump HC- PTO- 7A PTO Hydraulic Pump HC- PTO- 8A PTO Hydraulic Pump HC- PTO...
8 Mm Container Bolt SealGeneral Manufacturing - Shandong Tengxin Seal Co., Ltd - China - May 17, 2016 - contact company for price
High Security bolt seal with ABS covered and ' H' stamped at the bottom is a special locking device. It can be used on shipping container, truck and trailer doors and where high security tampering evidence is required. Various colors to choose. C- TP...
Safe Trade Tips
- Ask for business references and check them
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- Verify their business via their local Chamber of Commerce
- Search the internet using their website address, their business name, their phone and fax numbers, and their email addresses to see if you can find any feedback about them.
- Get to know more about scams to avoid: Internet Crime Complaint Center - International Financial Scams
- This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"


text:
Hebrews 8:13 - In that he saith, A new [covenant], he hath made the first old. Now that which decayeth and waxeth old [is] ready to vanish away.
Romans 7:6 - But now we are delivered from the law, that being dead wherein we were held; that we should serve in newness of spirit, and not [in] the oldness of the letter.
Jeremiah 31:31-34 - Behold, the days come, saith the LORD, that I will make a new covenant with the house of Israel, and with the house of Judah: (Read More...)
Matthew 5:17-18 - Think not that I am come to destroy the law, or the prophets: I am not come to destroy, but to fulfil. (Read More...)
James 2:10 - For whosoever shall keep the whole law, and yet offend in one [point], he is guilty of all.
1 John 2:3-6 - And hereby we do know that we know him, if we keep his commandments. (Read More...)
Topics and verses are auto-generated from user searches. If a verse or topic does not belong, please contact us. Some scripture references/categories courtesy of Open Bible .info under CC BY 3.0
Search the King James Version (KJV) for more references about Old Testament Law...
Bible Verses About God
Bible Verses About Children
Bible Verses About Divorce


text:
Uploading your own images
If you want to upload specific images to your study sets, first upgrade to Quizlet Plus or Quizlet Teacher.
Getting Started
You can add images to new sets as well as sets that you've already made.
To add images to a new set, click "Create Set" in the blue header.
To add images to an existing set, click "Edit" in the Tools section of the set page.
Uploading Images
You can upload your own images by dragging and dropping them into the definition field, or by clicking the image icon on the right side to browse your computer's files.
Drag and Drop
To add your own images quickly, use drag and drop. Click on and drag the image from your computer, and drop it directly to the right of the definition. The image will load and appear in this area.
Browsing Files
Click the image icon next to the definition to browse files on your computer.
In the options that appear, click on "Upload your own image."
Choose the image file, and click "Open."
Saving Your Set
Add images to as many terms as you'd like, and then click "Done."
These images will now show on the set page and in the study modes.
Other Questions
Can I upload multiple images at the same time?
You can upload multiple images at the same time, using either the drag and drop or the browse option. Just select as many images as you need and they will be added to empty rows in your set (or to new rows). Unfortunately right now you can only upload one image per term.
What types of image files can I upload?
We support uploading of jpegs, pngs, and gifs. You can upload images of any size, but we show downsized versions in the study modes and on the set page. You can view your image full screen from the set page or in Flashcards by clicking on the image.
Can I upload an image to the term side?
We only support uploading images to the second/definition side of your cards. However, you can choose to be prompted with either side in any study mode - this means you'll be able to see your images first when studying.
Can I upload images from an iPad, iPhone or Android device?
If you're using the Quizlet app for iPhone/iPad/iPod Touch, you can upload images from the app. If you're on an Android device, please go to the Quizlet.com website and log in to your account to upload images.


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Solarflare, Velocimetrics Integrate Trading Analysis Platforms
The two companies will jointly offer a distributed and customizable, real-time, end-to-end capture and analysis solution for trading firms.Solarflare, a specialist in application-intelligent 10/40 Gigabit Ethernet (10/40GbE) software and hardware technology, announced that it is partnering with business flow performance analytics specialist Velocimetrics. The two companies will jointly offer a distributed and customizable, real-time, end-to-end capture and analysis solution for trading firms. The combination of Solarflare's Capture SolarSystem, an open, flexible, high-performance persisted Ethernet capture platform, and Velocimetrics' analytics is designed to enable orders and trades to be tracked as they move across business-critical processes. The platform will provide detailed, live analysis and real-time issue alerting, which allows emerging problems to be quickly detected and their root cause understood and acted upon.
"Solarflare and Velocimetrics have complementary solutions that are critically needed to address regulatory, security and performance concerns," Mike Smith, vice president and general manager of hosted solutions for Solarflare, told eWEEK. "Our Capture SolarSystem is a comprehensive capture solution capable of storing indexed, precision, time-stamped packets to disk at line rate. Velocimetrics provides advanced network, middleware, market data and business-level analytics."
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Hideo Tokoro vs Asen Yamamoto
Rizin 4 World Grand Prix 2016 - Final Round watch video >>
Kron Gracie vs Hideo Tokoro
Openweight Grand Prix First Round watch video >>
Kizaemon Saiga vs Hideo "The Human Octopus" Tokoro
Rizin Fighting Federation 1: Day 1 watch video >>
http://www.smackhisface.com Kizatmon Saiga vs. Hideo Tokoro Rizin FF Day 1 watch video >>
n this clip, both Travis Conley and LC Davis, re-cap three specific heel hook attempts from the fight. They explain the details which allowed Davis to escape as well as submission details of the heel watch video >>
Hideo "The Human Octopus" Tokoro vs L.C. Davis
Full Fight Video
Bellator 135 - Warren vs. Galvao
Spike TV Main Card
WinStar World Casino and Resort, Thackerville, Oklahoma, United States
March 2 watch video >>
Onyok Transmonte of MAP Makati and Hideo Morikawa of Kyokushin Zendai Phil square it off in one of the most eagerly anticipated match ups in recent URCC history. Catch these two dangerous fighters fi watch video >>
Hideo Tokoro vs. Yusup SaadulaevFight For Japan: Genki Desu Ka Omisoka 2011December 31, 2011 watch video >>
FieLDS presents FIGHT FOR JAPAN??????!! ???!! 2011?(2011?12?31?(?)/????????????)??????????????????! ¦???:??????EP http://www.dreamofficial.com/ Fight card announcements for FieLDS presents FIGHT FOR watch video >>
Antonio Banuelos vs. Hideo Tokoro DREAM.17 World Bantamweight GP watch video >>


text:
More Videos...
Honeycomb airless tire on Ram 2500 4x4
Ram 2500 trying out honeycomb airless tires.
Concept Dodge Charger and Daytona
I bare no hatred towards the current Charger, I've got tons of respect for it. With that in mind I just wanted to have some fun and do my own version based off the old cars and give it a modern spin like what was done with the Challenger. This is all done for fun, I'm not out to start flame wars or anything. Opinions and criticism are most welcome. With that said this is my concept of at Charger and Daytona it's largely based off of the 69 & 70 with optional grills for both years. It's been designed in a way to support being put on the current Challenger chassis the dimensions of it are almost the same it's just a little longer in the front and back. The interior for the moment is almost the same as the current Charger. Some things are still subject to change like the backup lights being in the tail lights I might put them in the body. This is a fully modeled car with interior engine bay and trunk, I started designing it last year about this time on my laptop (pc had just died). The base design was done in about 5 days modeling the interior, motor and other details took a little longer and I spent the rest of the time tinkering with the body shape. The music is from the site danosongs(dot)com First track is I feel You Second track is Black box in the Ground Credit for the music goes of him. Anyway this is my concept for the new Charger and Daytona, opinions and criticism welcome, just keep it constructive. : )
Police Chase Scion XB in California
CHP chases a woman in a scion xb. erratic driver!
1967 Plymouth Hurst Barracuda - Jay Leno's Garage
Chris McCollum stops by to talk muscle and show Jay the project car that B&M purpose-built to relive the dream of the original Hurst Hemi Cuda that stormed the nationals and world finals in the '60s and '70s. » Subscribe: http://bit.ly/JLGSubscribe » Visit the Official Site: http://bit.ly/JLGOfficialSite THE BEST OF JAY LENO'S GARAGE » Exclusive First Looks: http://bit.ly/JLGExclusives » Ultra Rare Supercars: http://bit.ly/JLGSupercars » Jay's Book Club: http://bit.ly/JLGBookClub JAY LENO'S GARAGE ON SOCIAL Follow Jay: http://Twitter.com/LenosGarage Like Jay: http://Facebook.com/JayLenosGarage ABOUT JAY LENO'S GARAGE A new video every Sunday! Visit Jay Leno's Garage, the Emmy-winning series where Jay Leno gives car reviews, motorcycle reviews, compares cars, and shares his passion and expertise on anything that rolls, explodes, and makes noise. Classic cars, restomods, super cars like the McLaren P1, sports cars like Porsche 918 Spyder and Camaro Z28, cafe racers, vintage cars, and much, much more. Subscribe for more: http://full.sc/JD4OF8 NBC ON SOCIAL: NBC YouTube: http://full.sc/MtLxIM NBC Facebook: http://facebook.com/NBC NBC Twitter: http://twitter.com/NBC NBC Google+: https://plus.google.com/+NBC/posts 1967 Plymouth Hurst Barracuda - Jay Leno's Garage https://youtu.be/nR3RnkTNocE Jay Leno's Garage http://www.youtube.com/user/jaylenosgarage