text:
Jenny Lessley, DO Accepting New Patients
Dr. Jenny Lessley has joined the St. John Clinic team, working with Dr. Lee Mills, Dr. Brian Crotty, Dr. Trudy Milner, and Dr. Robert Paulsen. She earned her Bachelor of Science in Nutritional Sciences from Oklahoma State University. She then got her medical degree from Oklahoma State University Center for Health Sciences. She is a member of the American Osteopathic Association and the American College of Osteopathic Family Physicians. Dr. Lessley practices at 1919 S. Wheeling Ave., Lower Level in Tulsa. She is currently accepting new patients. To schedule an appointment, call 918-748-7890.
Dr. Jeff Wright Accepting New Patients in BA
Dr. Wright has practiced in Broken Arrow for more than 10 years and has a combined 20 years of service as a family medicine physician. Dr. Wright is active in the community with a variety of board and volunteer positions, and has served as medical director and in board positions for various nursing homes, hospitals and the Oklahoma State University College of Osteopathic Medicine and Surgery. Dr. Wright is available for all primary care needs. Dr. Wright and his staff are located at St. John Clinic at 5050 E. Kenosha St. in Broken Arrow. To schedule an appointment, call 918-355-9492. He is currently accepting new patients.
Dr. Ranne Now Accepting New Referrals
Dr. Ranne brings with him 20+ years of pediatric surgery in the Tulsa area. He received his bachelor's degree from the University of Arizona before earning his medical degree at the University of Arizona College of Medicine. He is a member of the American Pediatric Surgical Association and the American College of Surgeons. Dr. Ranne currently serves at the Medical Director of Pediatric Surgery at St. John Medical Center. He is board-certified with the American Board of Surgery in general surgery and pediatric surgery and with the American Board of Thoracic Surgery. He performs all forms of pediatric chest and abdominal operations, along with laproscopy, thorascopy, and pediatric GU procedures. Dr. Ranne practices at 1705 E. 19th St., Ste. 701. Please contact your primary care physician for a referral. He is currently accepting new referrals. Dr. Ranne accepts Medicaid and most insurance plans.
Drs. Stanley and David Smith Accepting New Patients in Owasso
Drs. Stanley and David Smith are currently accepting new patients at St. John Clinic in Owasso, OK. They both provide family medicine services to residents of Owasso and surrounding areas. Their practice is located at 13600 E. 86th St. N., Ste. 100 in Owasso. To schedule an appointment, call 918-272-9313.
Great patient care begins with superior nurses! Find your next career with St. John.
Delivering healthcare the right way starts with listening to our nurses, who are the heart of the care we provide. We listened to feedback from our nurses. Learn more about what we're doing to make St. John Health System a great environment for nurses and why St. John should be your next career move.
Bringing Healthcare to Independence
St. John Health System is pleased to announce St. John Clinic Convenience Care will be opening February 20. Hours of operation will be Monday-Saturday 8 a.m. - 8 p.m.
Ramona - Breast CenterRamona Wood
Saving Lives Through Early Detection
Ramona, a patient of Trudy Milner, D.O., primary care physician for St. John Clinic, learns the importance of getting routine mammograms to reduce the risk of breast cancer. With no symptoms present, Ramona did not know she had breast cancer until her mammogram. Today, Ramona has been breast cancer-free for eight years and looks forward to a long and healthy life with her grandchildren.
Joesphine - St. John ClinicJoesphine White
Joesphine White is a patient of Dr. Ashley Hildebrand, M.D., primary care physician for St. John Clinic Family Medical Care. Their patient/physician relationship portrays the importance of open communication and shared decision-making, as well as the reason St. John treats every patient like family.
St. John Online
Personal Medical Records
Quickly view your secure, electronic medical information and lab results.
St. John Clinic
Physician Search
Easily find the right physician to meet your needs.


text:
embedded systems programming
Embedded systems programming is the programming of an embedded system in some device using the permitted programming interfaces provided by that system. EmbeddedJava is an example of a development environment for programming embedded systems that will execute Java programs.
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subset: commoncrawl


text:
|Re:Last Time
|attached to Circuit City Rewards Execs As Stock Tanks
|Utility Computing
|attached to The 'Malware Economy' Evolves
|Re:So the US did all that?
|Re:Fuck You America!
|Re:Fuck You America!
|attached to Will ISP Web Content Filtering Continue To Grow?
|Re:Don't forget: you can't spell DMCA without the
|attached to Congress Creates Copyright Cops
|Verizon FUD Much?
|attached to Is Comcast Heading the Way of the Dinosaur?
|attached to Republican CNN/Youtube debate full of plants
|Re:Haven't found much
|Re:Haven't found much
|Re:Haven't found much - Actually...
|Re:Haven't found much
|attached to Quality Open Source Calendaring / Scheduling?
|Re:It doesn't mean they were the only people here
|Re:If only...
|attached to Gene Study Supports Single Bering Strait Migration
|attached to Rare Soviet Retro-Future Space Art
|Re:A Disco?!
|Re:A Disco?!
|A Disco?!
|attached to Slashdot Anniversary: Portland, OR, US
|Re:The GNU/Linux identity crisis is about Freedom
|attached to The Linux Identity Crisis
|Use Text Files
|attached to Programmer's Language-Aware Spell Checker?
|Re:Where Linux Applications Fall Short
|Where Linux Applications Fall Short
|attached to How Would You Refocus Linux Development?
|Re:Follow the Money
|attached to Hotmail vs Goodmail
"Dump the condiments. If we are to be eaten, we don't need to taste good." -- "Visionaries" cartoon


text:
meet verb (FOR THE FIRST TIME)
A1 [ T or I ] to see and talk to someone for the first time(和…)初次見面;(與…)相識
They met at work. 他們是在工作時認識的。
I met her in Hawaii. 我在夏威夷認識了她。
Would you like to meet my sister? 你願意認識一下我姐姐嗎?
Come and meet (= be introduced to) my friend Laura. 來,認識一下我的朋友蘿拉。
More examples
- I'd like you to meet Ann Gregory, my deputy.
- I'm dreading having to meet his parents.
- It's important to create a good impression when you meet a new client.
- It's not always easy to meet members of the opposite sex.
- We went backstage after the show to meet the actors.
meet verb (COME TOGETHER)
A1 [ I or T ] to come together with someone intentionally(與…)會面,會合
A1 [ T or I ] to come together with someone without intending to遇見,遇到
It's always awkward when you meet someone you know but you can't remember their name. 遇到你認識的人但卻記不起他們的名字,總會讓人很尷尬。
Guess who I met in town today. 猜猜今天我在城裡遇到了誰。
We met our old neighbours at an auction last Saturday. 我們在上週六的拍賣會上遇到了老鄰居。
More examples
- I'll meet you at the check-in desk.
- She's gone to meet Blake at the station.
- I'm meeting a group of friends for dinner tonight.
- The lovers met at a secret rendezvous in the park.
- We met on several occasions to discuss the issue.
meet verb (SATISFY)
C1 [ T ] to fulfil, satisfy, or achieve滿足;達到,完成
The workers' demands for higher pay were not met by the management. 管理層沒有滿足工人提高工資的要求。
They will only agree to sign the contract if certain conditions are met. 只有某些條件得到滿足,他們才會同意簽署合同。
More examples
- This type of computer is too slow and inflexible to meet many business needs.
- Can the sales force meet its financial objectives?
- They threatened to blow up the plane if their demands were not met.
- They agreed to raise the trade embargo if three conditions were met.
- His latest book met all my expectations.
meet verb (PLACE)
B1 [ T ] to wait at a place for someone or something to arrive迎接,等候
More examples
- A representative from the tour company will meet you at the check-in.
- You go on ahead of me, and I'll meet you there.
- It's very kind of you to come all the way to meet me.
- I'll meet you by the down escalator on the second floor.
- She's gone to meet Brian at the station.


text:
The only people with high hopes of Sunday's presidential election in Belarus were probably the incumbent President, Alexander Lukashenko, and his closest comrades. Anyone else will have harboured few illusions about the quality of Belarus's democracy – and that includes the nine candidates who took the risk of standing against him. Mr Lukashenko was duly re-elected with 80 per cent of the vote, easily exceeding the margin needed to avoid a second round.
The ferocity of the protests that followed, however, and the ruthless way in which they were suppressed, suggests that, after 16 years in power, the regime is vulnerable, and knows it. Several opposition candidates were beaten up, to the point of needing hospital treatment, and hundreds of protesters were arrested.
That the election fell far short of being free and fair was acknowledged almost at once by observers from the Organisation for Security and Co-operation in Europe. And while there were reports of stuffed ballot-boxes, the levers of power held by the President would have been enough to keep him in power; election-rigging takes many forms. Even so, the scale of Mr Lukashenko's victory and the brutal official response to the protests came as a disappointment.
The campaign itself had not been quite as bland a walkover as many had feared. It was freer and more fiercely contested than any fought by Mr Lukashenko – which, admittedly, is not saying much. Now, though, what appeared to be modest progress looks more like window-dressing designed to divert foreign critics. Opponents still risk their freedom and their lives.
But, as he embarks on a fourth term, Mr Lukashenko faces a dilemma. The economy, once his saving grace, is languishing. Yet outside help is unlikely to be forthcoming. After overtures from the EU earlier this year – which matched a cooling of relations with Russia – Belarus is isolated as never before. Meanwhile, as the latest protests showed, domestic dissent is becoming bolder. Mr Lukashenko is promising "political changes in general, but no change of power". The question is whether the one is possible without the other.
- More about:
- Belarus
- Minsk
- Police
- Russian Politics


text:
I know it. Our plant in central AL is closed tomorrow and they are
hoping beyond hope they can reopen Friday. Worried about those folks.
Pam Evans
Kemp, TX
zone 8A
----- Original Message -----
From: email@example.com
Sent: 9/15/2004 8:45:38 PM
To: email@example.com
Subject: Re: [CHAT] Ivan, new targets?
> In a message dated 9/15/2004 8:04:03 PM Central Standard Time,
> email@example.com writes:
> Zem... are you ready for the lashing caused by Ivan- stocked up on supplies
> and stuff? I assume you are still in it's path....Stay safe and keep in
> touch, if you can.
> We are only expecting rain, according to our weather honcho. Hopefully,
> that will exclude the possibility of tornadoes. The thought is that since we
> will be on the west side of Ivan the effects will be minimal. I hope this
> turns out to be the case. The people in AL are going to get it.
> zem
> zone 7
> West TN
> ---------------------------------------------------------------------
> Support hort.net -- join the hort.net fund drive!
> http://www.hort.net/funds/
Support hort.net -- join the hort.net fund drive!


text:
Café Scientifique in Toronto is organized and hosted by several organizations.
The Ontario Science Centre has a Cafe Scientifique series which is usually held on the third Saturday of each month at the Rivoli. To receive notification of upcoming Toronto events, send an e-mail with your name and e-mail address to Cafe Scientifique.
The Ontario Institutes of Cancer Research also produces a series which is CIHR-funded and focused on novel research about cancer. To receive notification of these upcoming Toronto events, send an e-mail with your name and e-mail address to Cafe Scientifique.
CIHR also hosts a Cafe Scientifique series in Toronto. For more information on this series of Cafes, please check the CIHR website at http://www.irsc.gc.ca/e/34951.html
Ontario Science Centre's Café Scientifique presents:
Your Brain on Music (click for pdf version)
Whether you feel nostalgic at certain songs, compelled to get up and dance to other tunes, or can't keep yourself from singing along – music has the ability to move us. Ever wondered about how we perceive and interpret music? Want to learn more about current scientific knowledge of the brain and music?
Join our guest speakers to examine the associations between music, behaviour, and neuroscience, get the scoop on current scientific knowledge, and discover intriguing innovations involving the brain and music.
Claude Alain - Assistant Director and Senior Scientist, Rotman Research Institute at Baycrest, and Professor of Psychology at University of Toronto
Sarah Nematallah – Violinist in Cecilia String Quartet and Music Educator
Sarah Robichaud - Dancer, Fitness expert, Founder & Creative Director of Dancing with Parkinson's
Saturday January 24, 2015 - 4pm to pm
The Rivoli, 334 Queen St. W (just east of Spadina)
This event is produced in collaboration with the Ontario Brain Institute
FREE event!
Join in for an evening of drinks, debate, discussion
Ontario Science Centre's Café Scientifique presents:
Your Brain on Food
Ever wonder why some people love Brussels sprouts, or binge on potato chips, or can't turn down an item containing bacon? Our brains have a huge influence on the food that we choose to eat. But does it also work the other way around? Does diet influence our brain health? Can we ward off brain diseases by choosing certain foods? Why are there are snacks that we enjoy or despise? What tricks do chefs use when creating a menu to appeal to our senses?
Join us for an afternoon of investigating the links between food and the brain with our guest speakers!
Dr. Carol Greenwood - Senior Scientist, Rotman Research Institute and Department of Foods and Nutrition, Baycrest, and Professor, Department of Foods and Nutrition, University of Toronto
Wallace Wong - Culinary Arts Instructor at Nella Cucina Culinary School.
Saturday February 21, 2015 - 4pm to 6pm
Nella Cucina, 2nd floor culinary classroom
876 Bathurst Street (1 block north of Bloor)
Please note: There is limited capacity at this venue - please arrive early.
FREE event!
Join in for an afternoon of drinks, debate, discussion
This event is produced in collaboration with the Ontario Brain Institute
Ontario Science Centre's Café Scientifique presents:
Your Brain on Exercise
What role does your brain play when you work out? Can physical movement have an impact on your risk for developing dementia? Does exercise really release certain neurotransmitters to affect your health and adjust your mood? Can mindfulness lead to better physical performance? If you've ever wondered about how your workout routine (or lack of one) impacts your brain health, take this opportunity to exercise your mind and find out more.
Join us for an afternoon to investigate the links between the brain and exercise with our guest speakers! Prepare to challenge your mind and your muscles!
Laura Middleton PhD - Assistant Professor, Department of Kinesiology, University of Waterloo
Alex Hutchinson PhD - Journalist, former national-team distance runner and postdoctoral physicist, author of "Which Comes First, Cardio or Weights? Fitness Myths, Training Truths, and Other Surprising Discoveries from the Science of Exercise"
Stacy Irvine BSc. Kin, M.Sc., D.C. - Personal Trainer, Chiropractor, founder and co-owner of Totum Life Science
Mathieu Ranger, Researcher, Ontario Science Centre
Saturday March 21, 2015 - 4 pm to 6 pm
Totum Life Science King
445 King Street West, Suite 101
(1 block west of Spadina)
FREE event!
Join in for an afternoon of drinks, debate, discussion
This event is produced in collaboration with the Ontario Brain Institute
CIHR Café Scientifique presents:
Myths and Truths about Secondhand Smoke and E-Cigarettes (click for pdf poster)
The link between smoking and cancer is well established.
What are the health risks of so called second-hand smoke? What is third-hand smoking?
Are new products like e-cigarettes, which do not produce smoke, safer?
Recent legislation will ban smoking on patios, on sports fields and in or near playgrounds.
Are we taking the right steps to prevent exposure to second-hand smoke?
Join our panel of experts for a lively discussion on the myths and truths around smoking.
Arshnoor Khoja, RN - Public Health Nurse, Public Health Toronto
Alison Crepinsek - Campaign to Control Cancer
Donna Francis, Researcher, Ontario Science Centre
Tuesday November 25th, 2014 - 5pm to 7 pm
Toronto Reference Library, Novella Room on 2nd Floor
789 Yonge Street, Toronto (One street north of Bloor St.)
Please RSVP to: http://myths-and-truths-about-second-hand-smoke.eventbrite.ca
This event is produced by the Ontario Institute of Cancer Research
with the collaboration of the Ontario Science Centre,
and with the financial support of the Canadian Institutes of Health Research
CIHR Café Scientifique presents:
Myths and Truths about Genetic Heredity in Cancer (click for pdf poster)
Cancer is a common disease, with many people having a history of one or more family members affected by it. What role does genetic heredity play in cancer? How common is it for specific cancers to "run in the family?" What do we know about inheritable cancer genes and how does this affect research, detection and treatment?
Dr. Nancy Baxter, MD, PhD - Division Chief, Division of General Surgery, St. Michael's Hospital and Scientist, St. Michael's Hospital
Kelly A. Metcalfe, RN, PhD - Professor, Faculty of Medicine, University of Toronto, and Adjunct Scientist, Women's College Research Institute
Aletta Poll, M.Sc - Genetic Counsellor, Familial Breast Cancer Research Unit, Women's College Research Institute
Donna Francis, Researcher, Ontario Science Centre
Wednesday May 7, 2014 - 6pm to 8 pm
The Duke of York Pub, Cellar Room
39 Prince Arthur Avenue, Toronto (near St. George subway station)
Please RSVP to: firstname.lastname@example.com
This event is produced by the Ontario Institute of Cancer Research
with the collaboration of the Ontario Science Centre,
and with the financial support of the Canadian Institutes of Health Research
Ontario Science Centre's Café Scientifique presents:
Art & Science: Same process, different products? (click for pdf poster)
Take a closer look at the intersections between art and science. Is there more in common than you imagined at first glance? Are these two fields just different ways of looking at the world? Join a variety of artists and scientists for a spirited discussion about the overlap between art and science. View works from the Occam's Razor exhibition and exchange ideas about the true meaning of art and science.
Natasha Kovacevic, PhD - creative producer, My Virtual Dream and Program Manager at the Centre for Integrative Brain Dynamics at the Rotman Research Institute, Baycrest Centre
Clint Enns - PhD student, York University
Scott Menary, PhD - Professor of Physics, York University
Sally McKay, PhD - Professor of Studio Art and Art History, McMaster University
Wednesday April 9th, 2014 - 6pm to 8:30pm,
Gladstone Hotel 1214 Queen St W
followed by viewing of artworks at Propeller Centre, 984 Queen St W until 9:30
Presented in conjunction with the Occam's Razor exhibition
at the Propeller Centre for the Visual Arts (PCVA) and the !dea Gallery at the Ontario Science Centre
CIHR Café Scientifique presents: Healthy Eating + Physical Activity = Cancer Risk Reduction
Are you eating right and being active enough?
Blueberries. Red meat. Fibre. Wine. Chocolate. Antioxidant. Vitamin D. Eat a balanced diet. Consume in moderation. We are flooded daily with new reports describing what we should or should not do to reduce our risk of cancer. What is the current advice on good nutritional habits that could reduce the risk of cancer?
Take the stairs. Walk, run, bike. Exercise 30 minutes per day. ParticipACTION. Is physical activity also important in reducing our risk of cancer? What is the current advice on good active lifestyle habits that could also reduce the risk of cancer?
Join some of Canada's leading faculty in nutrition and exercise physiology for an evening of open discussion on the role of food and physical activity in reducing the risk of cancer.
Come and learn how we can eat and move our way to a healthy lifestyle.
Dr. Rena Mendelson - Professor of Nutrition, Ryerson University
Dr. Robert Ross - Professor of Exercise Physiology, School of Kinesiology and Health Studies, Queen's University
Moderator:Dr. Michelle Brazas - Research and Knowledge Exchange Manager, Ontario Institute for Cancer Research
Wednesday, May 8, 2013 - 6 to 8 p.m.
The Duke of York Pub, Cellar Room
39 Prince Arthur Avenue, Toronto(near St. George subway station)
Please RSVP to: firstname.lastname@example.com
Spring is almost here! With the arrival of warmer weather, many Canadians will be shedding their winter coats and sweaters for lighter clothing and enjoying longer periods outdoors in the sunshine. While wonderful, the sun's rays also pose a risk for skin cancers. How much UV exposure is too much? How is UV exposure measured and how do we report this in the daily news? What are effective strategies in skin cancer prevention?
Join CityNews meteorologist Natasha Ramsahai and one of Canada's leading melanoma clinicians - Dr. Danny Ghazarian for an evening of open discussion on the role of UV radiation in skin cancer, and our ability to monitor and control UV exposure. Come and gain a whole new appreciation for the power of the sun.
•Dr. Danny Ghazarian - Consultant Dermatopathologist, Director of Education, University Health Network, Associate Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto
•Natasha Ramsahai - Meteorologist, CityNews, Education Outreach Canadian Meteorological and Oceanographic Society
Dr. Michelle Brazas - Research and Knowledge Exchange Manager, Ontario Institute for Cancer Research
Monday, April 29, 2013 - 6 to 8 p.m.
The Duke of York Pub, Cellar Room
39 Prince Arthur Avenue, Toronto (near St. George subway station)
Please RSVP to: email@example.com
This event is produced by the Ontario Institute of Cancer Research
with the collaboration of the Ontario Science Centre
Playing Games with our Brains: Are Games more important than we think?
Video Games are everywhere. From apps on your smartphone to motion-controlled console games, it is likely that you've played a game or two in the last month. Curious about what playing games does to your brain? Wonder what scientists have discovered about our brains by using games? Join us for a discussion on the importance of games and find out about the groundbreaking ways that they are being used for the sake of science and education.
Got an opinion? Join us for drinks, discussion and debate.
Saturday April 20th, 4-6 pm
at The Rivoli, 334 Queen St. W
Psst…It's February, do you know where your resolutions are?
click image for printable pdf version
Each year, many of us resolve to change our lives. We vow to exercise more, eat healthier food, quit smoking, save money, or find a new love. However, by the end of February, the gyms that were packed in January are ghost towns, and the junk food has crept back into the kitchen cupboards. What if we analyse this phenomenon scientifically?
Do we have a limited amount of willpower to exert?
How can we use social psychology to increase our likelihood of success?
If there is just one resolution you keep this year – attend this science café event!
Jennifer Sygo, M.Sc., RD - Registered Dietitian and Sports Nutritionist, Cleveland Clinic Canada
Anne Bergen, PhD (Social Psychology) -Knowledge Mobilization Coordinator, College of Social and Applied Human Sciences, University of Guelph
Valerie Taylor, MD, PhD - Psychiatrist-in-Chief, Women's College Hospital, Academic Lead, Division of Women's Mental Health, University of Toronto, Associate Professor, Department of Psychiatry, University of Toronto
Got an opinion? Join us for drinks, discussion and debate.
Saturday February 16th, 4-6 pm
at The Rivoli, 334 Queen St. W
click image for printable poster version
Ontario Science Centre Cafe Scientifique presents:
Does Arctic Science have an impact on Toronto life?
The Arctic is warming twice as quickly as the rest of the planet. We often read about the warning signs: receding glaciers, reduced ice coverage, ice-free Northern sea routes, and vanishing habitats. What does this mean for life in the North? Does it have any impact on urban life in Toronto?
Join us for a fresh look at science in the North with Canadian scientists in biology, geology and marine biology. Find out for yourself how their research makes an impact on residents of the Arctic, and get in on the conversation.
Kathy Conlan, PhD - Marine Biologist and Author
David Gray, PhD - Arctic Biologist and Historian
Peter Croal – Geologist
This event is produced in collaboration with Students on Ice.
This event is part of the Science in Canada's North Café Scientifique Series.
The Ontario Science Centre gratefully acknowledges the support of the W. Garfield Weston Foundation and
the Canadian Association of Science Centres for their support of this event.
November 19, 2012
6 pm to 8 pm
The Gladstone Hotel Ballroom, 1214 Queen Street West, Toronto
CIHR Café Scientifique presents:
Can Viruses Kill Cancer?
Not all viruses are bad.
When most people think of viruses, they think of getting a cold or the flu. They also worry about catching a virus as it spreads through their community. While infection from some viruses can be prevented using vaccines, others cannot and people get sick.
But viruses also have a good side and may even be able to make people healthier. Cancer researchers today are exploring how viruses can be adapted to infect and spread in tumour tissues without harming the surrounding normal tissue. The results are promising and they could lead to a whole new type of cancer treatment with fewer side effects for patients.
Join some of Canada's leading faculty for an evening of open discussion on how some viruses can be adapted to kill cancer cells and how these viruses differ from the ones we worry about.
You won't look at the common cold in the same way again.
This event is produced by the Ontario Institute of Cancer Research with the collaboration of the Ontario Science Centre
- Dr. John C. Bell- Senior Scientist, Cancer Therapeutics, Ottawa Hospital Research Institute
- Dr. David N. Fisman - Associate Professor, Division of Epidemiology, Dalla Lana School of Public Health
- Donna Francis - Researcher, Ontario Science Centre
Thursday, February 9, 2012
6 to 8 p.m.
The Duke of York Pub - 39 Prince Arthur Avenue, Toronto
Please RSVP to: email@example.com
Click on the topic to view the poster from a previous Café:
2011 Ontario Science Centre Cafe Scientifique Events at the Rivoli
- Café Scientifique Special Edition: Science Goes to the Movies (June 17, 2011)
- Nuclear Energy: What does the future hold? (April 16, 2011)
- Is there a Formula for Beauty? (March 19, 2011)
- QUANTUM: What is it and why should I care? (January 15, 2011)


text:
Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus
- Yingxia Liu†1,
- Shaoyuan Li†2,
- Guoliang Zhang1,
- Guang Nie1,
- Zhizhong Meng3,
- Dongting Mao2,
- Chang Chen2,
- Xinchun Chen1,
- Boping Zhou1 and
- Gucheng Zeng2Email author
© Liu et al.; licensee BioMed Central Ltd. 2013
Received: 14 May 2013
Accepted: 31 July 2013
Published: 8 August 2013
Host genetic variations may contribute to disease susceptibility of influenza. IL-1A and IL-1B are important inflammatory cytokines that mediate the inflammation and initiate the immune response against virus infection. In this study, we investigated the relationship between single-nucleotide polymorphisms (SNPs) of Interleukin-1A (IL-1A) and Interleukin-1B (IL-1B) and the susceptibility to 2009 pandemic A/H1N1 influenza (A(H1N1)pdm09). 167 patients whom were confirmed with A(H1N1)pdm09 and 192 healthy controls were included in this study. Four SNPs (rs1304037, rs16347, rs17561, rs2071373) in IL1A gene and three SNPs (rs1143623, rs3917345, rs1143627) in IL1B gene were genotyped by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry platform, and the associations of the genetic variants of IL-1 with susceptibility to A(H1N1)pdm09 were then assessed.
The polymorphisms of rs17561 in IL1A gene and rs1143627 in IL1B gene were found to be associated with susceptibility to A(H1N1)pdm09 with P values of 0.003 (OR 2.08, 95% CI 1.27-3.41) and 0.002 (OR 1.62 , 95% CI 1.20-2.18), respectively. However, no significant difference in allelic frequency was observed for other SNPs between cases and controls.
This study provides a new insight into pathogenesis of A(H1N1)pdm09, suggesting that genetic variants of IL-1A and IL-1B may exert a substantial impact on the susceptibility of A(H1N1)pdm09 virus infection.
KeywordsInterleukin-1 H1N1 Influenza Single-nucleotide polymorphisms (SNPs)
The global pandemic caused by the novel A(H1N1)pdm09 was first declared in Mexico and the United States in April 2009, inducing severe morbidity and mortality in a subset of the population [1]. This novel strain of influenza A virus is made up of a unique combination of gene segments from Eurasian swine, human and avian influenza viruses [2]. Thus, seasonal influenza vaccines do not confer effective cross-protection against A(H1N1)pdm09 virus infection. While the virulence and evolution of influenza virus have been intensively studied, the impact of host genetic background on the susceptibility to pandemic influenza virus infection remains largely unknown.
It has been suggested that the host genetic factors may affect the susceptibility and progression of microbial infections [3]. For example, Chinese population-attributable risk for severe influenza infection was ten-fold greater than Northern European population-attributable risk because of the high frequency of rs12252-C in Han Chinese [4]. Meanwhile, the SNPs in TLR3 [5], CD55 [6], C1q and FCGR2A [7], TNF [8, 9], LTA, IL8 and IL1B [9] were suggested to be connected with the severity of A(H1N1)pdm09 virus infection.
During influenza virus infection, IL-1B has been demonstrated to mediate acute pulmonary inflammatory pathology [10]. Pro-IL-1B was cleaved by caspase-1 which was activated through the formation of the NLRP3 inflammasome [11]. Recent studies have shown that IL-1A secretion was also regulated by the NLRP3 inflammasome [12, 13]. In addition, IL-1A and IL-1B induced the expression of a variety of inflammatory mediators, which may initiate the cascade of inflammatory responses and induced the activation of T cells [14, 15]. To date, few studies have explored the association between IL-1 polymorphisms and A/H1N1 susceptibility [9]. Therefore, investigation of whether the genetic variants in IL-1 impact the susceptibility to A(H1N1)pdm09 is of great importance.
In this study, we examined 7 SNPs in IL1 gene and evaluated their association with A(H1N1)pdm09 susceptibility. The results indicated that rs17561 polymorphism in IL1A gene and rs1143627 polymorphism in IL1B gene, two novel SNPs of IL-1 gene, contributed to the susceptibility to A(H1N1)pdm09.
Study subjects and samples
167 patients with A(H1N1)pdm09 were recruited in Shenzhen Third People's Hospital, China during 2009 influenza pandemic period. 167 patients (91 males and 76 females) were included in this study, and the average age of patients is 22.37 (SD = 11.95). The diagnosis of A(H1N1)pdm09 was followed the guideline released by the Ministry of Health of the People's Republic of China. 192 Healthy donors (HD) were from Shenzhen, China during the same period, and no occurrence of A(H1N1)pdm09 was found in the HD during 1 year's follow-up. 192 health individuals (101 males and 91 females) were recruited as controls, and the average age of healthy individuals is 24.53 (SD = 10.29). All subjects were Chinese Han people whom have received flu vaccine previously. Venous blood was drawn from all subjects after an overnight fasting. Blood corpuscles were stored at −80°C for DNA purification. The study was approved by the Institutional Review Board of Shenzhen Third People's Hospital, and informed consent was obtained from each participant. There is no significant difference for the average age and gender distribution between cases and controls (P >0.05).
DNA extraction and SNP selection
Genomic DNA was obtained from peripheral blood samples, using the QIAamp DNA Blood Mini kit (Qiagen, Hilden, Germany) according to the manufacturer's instruction. Isolated DNA was stored at −80°C before usage. SNPs were selected according to methods described previously [16], with focusing on their potential regulatory roles, such as transcription binding sites in the promoter region, microRNA target sites in the 3′ untranslated region (UTR), protein phosphorylation sites in the extrons and other putative regulation sites.
Outline of primers for IL1A, IL1B SNP genotyping
Forward primer
Reverse primer
Un-extension primer
SNPs' genotyping was based on analysis of primer extension products generated from previously amplified genomic DNA using a chip-based MALDI-TOF mass spectrometry platform (Sequenom, San Diego, CA). The amplification PCR primer pairs and the extend primers were designed by MassARRAY assay designer software v3.1, in combination with manual adjustment (Table 1). PCR amplification was performed in the HotStar buffer system (Qiagen, Hilden, Germany). Extend products were dispensed onto a 384-spot plate, and Thermo cycling (Applied Biosystems, USA) was initiated at 94°C for 5 min; followed by 40 cycles of 94°C for 30 s, 55°C for 30 s, 72°C for 30 s; and a final extension of 72°C for 3 min to amplify identical length products. Following genomic amplification of the target regions, excess deoxyribonucleotide triphosphates were dephosphorylated with 2 μL shrimp alkaline phosphatase by incubation at 37°C for 60 min, and stopped by inactivation at 85°C for 10 min.
The selected SNPs were analyzed in one primer-extension reaction, the PCR was then performed at 94°C for 15 min, 40 cycles of 94°C for 5 s, (52°C for 5 s, and 80°C for 5 s, 5 cycles), followed by a final extension done at 72°C for 3 min. After desalting extension products for MALDI-TOF mass spectrometry analysis by the addition of 16 μL water and 6 mg of clean resin to each sample. Data analysis was performed by using MassARRAY typer software 4.0.
Statistical analysis
The frequencies of allele and genotype were determined by direct counting. All SNPs investigated in this study were tested for Hardy-Weinberg equilibrium. The Pearson χ 2 test was used to compare allele and genotype distribution in cases and controls. Odds ratios (ORs) and their 95% confidence intervals (CI) were calculated with Miettinen's method. Each SNP was calculated under four alternative models (dominant, recessive, multiplicative and additive), as previously described [4, 24–26]. Bonferroni correction was used to compare the allelic frequency between participants with different genotypes. All the statistical procedures were performed with SPSS13.0 software. P <0.05 was considered to be significant.
Selection and genotyping of IL1A/IL1B SNPs
Association of IL1A gene SNPs with A/H1N1 susceptibility
Distribution of genotype and allele frequencies of IL1A SNP
Different genetics models
No (%)
No (%)
P value
P value
P value
P value
161 (83.9)
130 (77.8)
1.32 (0.81-2.15)
1.48 (0.87-2.51)
0.38 (0.04-3.69)
28 (14.6)
36 (21.6)
0.26 (0.03-2.63)
3 (1.5)
1 (0.6)
0.41 (0.04-4.02)
81 (42.2)
68 (40.7)
1.12 (0.82-1.51)
1.06 (0.70-1.62)
1.36 (0.74-2.48)
88 (45.8)
73 (43.7)
1.36 (0.72-2.59)
23 (12.0)
26 (15.6)
1.35 (0.70-2.57)
166 (86.5)
121 (72.5)
2.08 (1.27-3.41)
2.43 (1.42-4.15)
0.54 (0.05-6.37)
24 (12.5)
45 (26.9)
0.27 (0.02-3.10)
2 (1.0)
1 (0.6)
0.69 (0.06-7.66)
80 (41.7)
68 (40.7)
1.13 (0.83-1.53)
1.04 (0.68-1.59)
1.51 (0.81-2.84)
92 (47.9)
74 (44.3)
1.55 (0.80-3.02)
20 (10.4)
25 (15.0)
1.47 (0.75-2.88)
Association of IL1B gene SNPs with A/H1N1 susceptibility
Distribution of genotype and allele frequencies of IL1B SNP
4 statistical models
No (%)
No (%)
P value
P value
P value
P value
57 (29.7)
37 (22.2)
1.27 (0.95-1.71)
1.48 (0.92-2.40)
1.28 (0.79-2.07)
92 (47.9)
85 (50.9)
1.13 (0.68-1.89)
43 (22.4)
45 (26.9)
1.61 (0.90-2.90)
191 (99.5)
166 (99.4)
1.15 (0.07-18.47)
1.15 (0.07-18.55)
1 (0.5)
1 (0.6)
0 (0.0)
0 (0.0)
84 (43.8)
47 (28.1)
1.62 (1.20-2.18)
1.99 (1.28-3.09)
1.68 (0.97-2.91)
81 (42.2)
84 (50.3)
1.29 (0.72-2.31)
36 (21.6)
2.38 (1.29-4.40)
In this study, we analyzed the genetic factors impacting the susceptibility to A(H1N1)pdm09. We examined 7 SNPs in IL1A and IL1B genes and evaluated the association between SNPs of IL-1 and A(H1N1)pdm09 susceptibility. We found that rs17561 polymorphism in IL1A gene and rs1143627 polymorphism in IL1B gene contributed to the susceptibility to A(H1N1)pdm09.
In humans, IL-1 exists in two forms, IL-1A (encoded by IL1A gene) and IL-1B (encoded by IL1B gene), and both forms of IL-1 locate on chromosome 2 [27]. IL-1A and IL-1B are inflammatory cytokines that play important roles in recruitment of the immune and inflammatory cells and development of adaptive immune responses [28]. Accumulating evidence has suggested that IL-1A and IL-1B play important roles in innate immunity against viral infection. Infection of viruses such as, hepatitis A virus (HAV) [29], epstein-barr virus (EBV) [30], HIV [31] and human papilloma viruses (hrHPVs) [3], may activate the extracellular signal and induce production of IL-1. Several studies have documented an early rise in IL-1 in bronchoalveolar lavage (BAL) fluids or lung homogenates in temporal association with symptom formation and lung pathology after infection with A/PR/8/34 H1N1 or A(H1N1)pdm09 [32–34].
In fact, IL1A with rs17561 allele T has been suggested to be associated with immunopathogenesis of several diseases, including nasal polyposis [22], chronic rhinosinusitis [23]. Rs17561 polymorphism was related with high levels of C-reactive protein, which can regulate the severity inflammatory response [35]. Interestingly, our result also indicated that rs17561 allele T increased the risk of A(H1N1)pdm09 susceptibility. In contrast, rs1304037 and rs16347 locating on 3′UTR, and rs2071373 locating on intron box did not display any association with the susceptibility to A(H1N1)pdm09. The SNP rs17561 represents a nonsynonymous mutation (Ala114Ser) in IL-1A protein, suggesting that this mutation may lead to a potential functional variation in host susceptibility to A(H1N1)pdm09. However, the exact mechanism needs to be further studied.
During influenza virus infection, the immune response was triggered by the influenza virus ion channel M2 which was essential for virus entry and replication, leading to the assembly of inflammasome in macrophages and dendritic cells (DCs) [36]. Then, the activation of inflammasome resulted in the cleavage of pro-IL-1B by caspase-1 and produced the mature form of IL-1B [37]. IL-1B may act with IL-6 to induce IFN-γ production by T cells [14] and promote RORγt expression and Th-17 polarization of CD4 T cells [15]. The Th-17 effector cells produced IL-17 and facilitated the recruitment of neutrophils and inflammation [38].
Here, we found a significantly high frequency of IL-1B rs1143627 allele C in A/H1N1 patients, suggesting the hosts with allele C were more susceptible to this virus infection. Importantly,the frequency of the rs1143627 allele C is quite rich in Han Chinese (minor allele frequency = 0.476). Thus, elucidation of the underlying mechanism of the polymorphism of rs1143627 is of great importance for in-depth understanding of the susceptibility of influenza in Chinese population. Rs1143627 polymorphism involved the variation of IL-1B −31 allele C to T and is located on the TATA box of IL1B gene promoter region, which has been demonstrated to be a critical motif partially determining IL-1B transcriptional efficiency [39]. Furthermore, the rs1143627 and its franking sequences can be bound by transcription factors, including c/EBPβ, TBP and Spi-1 [40, 41]. Electrophoretic mobility shift assay (EMSA) analysis suggested that c/EBPβ confers a much higher affinity to rs1143627-C probe than to T probe [40]. Several reports have shown that the allele T of rs1143627 enhanced IL-1B protein expression [40, 42], and T-allele of rs1143627 was considered to be a pro-inflammatory allele [41]. People who carry allele T had a higher IL-1B expression that may promote the production of IFN-γ, which plays an important role in virus clearance [14]. IL-1B may also facilitate the differentiation and proliferation of pro-inflammatory cells such as Th-17 in humans [15, 43]. In contrast, the expression of IL-1B may be much lower in people who carry allele C, leading to weaker immune response during viral infection.
Thus, it is possible that IL1B SNP rs1143627 C allele has a lower binding affinity to c/EBPβ and reduced levels of IL-1B expression, which may therefore weaken the inflammatory response of Th-17 and Th-1 cells in humans during influenza infection. A cohort of study with a larger population size is needed to further confirm the association of IL1A rs17561 allele T and IL1B rs1143627 allele C with an increased risk for the susceptibility to A(H1N1)pdm09. Functional studies will also be needed to further investigate the role and mechanism of genetic variants of IL-1 on the impact of susceptibility to A(H1N1)pdm09.
IL1A rs17561 allele T and IL1B rs1143627 allele C may confer an increased risk for the susceptibility to A(H1N1)pdm09. Thus, this study provides a new insight into the immunopathogenesis of influenza A virus infection in humans.
Authors' information
Y Liu, MD, PhD, Director, S Li, BS, G Zhang, MD, PhD, G Nie, PhD, Z Meng, PhD, D Mao, BS, C Chen, BS, X Chen, MD, PhD, B Zhou, MD, PhD, Dean, G. Zeng, PhD.
- SNPs:
Single-nucleotide polymorphisms
- A(H1N1)pdm09:
2009 pandemic A/H1N1 influenza
Matrix-assisted laser desorption/ionization time-of-flight
Odds ratio
Confidence interval.
This work was supported by NSFC (No. 31170847 and No.30873264) and Shenzhen Science and Technology Foundation (No.201002107 and No.201202063) and Shenzhen Key Clinical Department of Emerging Infectious Diseases. We thank staffs, doctors and nurses of Shenzhen Third People's Hospital for patient management, sample collection and analysis in this work.
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
This Classified is Closed
For Sale:
Sennheiser HD-448 HD448 Excellent Condition
Will Ship To: Anywhere
Sennheiser Closed-Back HD-448 in excellent condition
Bought new in September 2010; in super clean/excellent condition; very low hours (used them for the odd gaming session and the odd travel). The pads are full and look new. They're light as a feather and plugged directly into my main system these little guys are *very* impressive sounding--for the money or not.
Comes with original accessories (travel pouch, extension cable, and 1/4 inch adapter); selling for $OLD plus shipping.
Edited by Toob-Toob - 12/15/12 at 7:17am


text:
I turned vegan at the beginning of this year which was a fairly easy transition for me as I had been a vegetarian for 4 years and didn't eat very much dairy (Minstrels, Mini Eggs and feta cheese were my main weaknesses). Being vegan doesn't automatically equal healthy and my emphasis when cooking has been to cook wholesome, healthy meals packed with lots of fresh veg, herbs and spices (then I don't feel quite so guilty for sneaking in some M&S veggie percy pigs..)
The books I've been turning to are Anna Jones' A Modern Way To Eat & A Modern Way To Cook, whilst both books are vegetarian most of her recipes are easily adapted for vegans. With recipes like 'Dhal with crispy sweet potato and quick coconut chutney' and 'Carrot and chickpea pancake with lemon-spiked dressing', leave these books on your coffee table and even the meat-loving carnivores will find something up their street.
The River Cafe Cook Book Green is an oldie but a goodie. Again, not strictly vegan but there are tons of recipes that are and any others are easily adapted. The book is a dedication to all that is great about the humble veg and it's organised by month and what is in season in each month. Some of my favourites recipes are the simple salads like the 'Mint and lentil salad'.
The Mildreds cookbook is the highly anticipated cookbook from the vegetarian restaurant Mildreds in London (well worth a visit if you're in London), all recipes are vegetarian but have clear labels if they are vegan or gluten-free, any others can again be easily adapted to a vegan diet. Some of my favourites from this book are the 'Sri Lankan sweet potato & cashew nut curry' and the 'saffron & pea risotto cakes'
Last but not least the two newest additions to my book shelf are Aine Carlin's Keep It Vegan & The New Vegan. I'm so happy my hubby discovered these for me, all my latest dishes have come from these books. The recipes are simple, fool-proof and delicious. Her 'Macaro-no cheese with crispy kale' blew my mind and I haven't yet made a dud dish from her books. I'm excited to try her 'Swedish-style vegballs with mash and creamy mustard sauce' this evening.


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PSD to HTML/CSS
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Basic PSD to HTML/CSS conversion.
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text:
Fifth Circuit Contract Cases
Negotiable Instrument Cases, Dockets and Filings
Cases filed
Cases 1 - 10 of 1,154
Regions Bank v. Martinez
as 4:2017cv00569
Plaintiff: Regions Bank
Defendant: Nestor Martinez
Cause Of Action: Diversity-Breach of Contract
Court: Fifth Circuit › Texas › Texas Southern District Court
Regions Bank v. Master Sound Co Inc et al
as 3:2017cv00489
Plaintiff: Regions Bank
Defendant: Master Sound Co Inc, Edwin Wayne Dalton
Cause Of Action: Diversity-Breach of Contract
Schmidt v. JPMorgan Chase Bank, NA et al
as 4:2017cv00532
Plaintiff: Jimmy D. Schmidt
Defendant: JPMorgan Chase Bank, NA , JPMorgan Chase & Co. , Chase Bank Card Services Inc.
Cause Of Action: Petition for Removal- Negotiable Instrumen
Court: Fifth Circuit › Texas › Texas Southern District Court
RREAF Holdings LLC et al v. First Capital Real Estate Investments LLC
as 3:2017cv00469
Plaintiff: RREAF Holdings LLC , RREAF Holdings (O&G Portfolio Number 1) LLC
Defendant: First Capital Real Estate Investments LLC
Cause Of Action: Breach of Contract
Mack Financial Services v. Fodale
as 5:2017cv00285
Defendant: Christine L Fodale
Plaintiff: Mack Financial Services
Cause Of Action: Diversity-Breach of Contract
Roberts-Harris v. JPMorgan Chase Bank, N.A.
as 4:2017cv00150
Plaintiff: Patricia Roberts-Harris
Defendant: JPMorgan Chase Bank, N.A.
Cause Of Action: Diversity-Petition for Removal
whitmore v. Ditech Financial LLC
as 2:2017cv01265
Plaintiff: wilmore wiley whitmore
Defendant: Ditech Financial LLC
Cause Of Action: Cause Code Unknown
Midwest Feeders, Incorporated v. Bank of Franklin
as 17-60092
Plaintiff - Appellant: MIDWEST FEEDERS, INCORPORATED
Defendant - Appellee: BANK OF FRANKLIN
Type: Contract › Negotiable instruments
Thrift Way, Inc. v. Meza et al
as 4:2017cv00142
Plaintiff: Thrift Way, Inc.
Defendant: Juan Antonio Meza, United States of America
Cause Of Action: Default of Promissory Note
Green Riverside Inc v. Black Jack Oil Company Inc et al
as 3:2017cv00396
Plaintiff: Green Riverside Inc
Defendant: Black Jack Oil Company Inc, Kevin L Wilson, M L Vines Jr
Cause Of Action: Diversity-Breach of Contract
Disclaimer: Justia Dockets & Filings provides public litigation records from the federal appellate and district courts. These filings and docket sheets should not be considered findings of fact or liability, nor do they necessarily reflect the view of Justia.


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Mbah a Moute cleared to play, joins teammates
Minneapolis - Bucks forward Luc Richard Mbah a Moute had his work visa issue settled Friday and he took a later flight to join his teammates for Saturday's preseason opener against the Minnesota Timberwolves.
Even though Mbah a Moute has yet to practice, Bucks coach Scott Skiles said at shootaround he intended to put the fourth-year forward on the floor, at least for limited minutes.
"I'll talk to him before tonight and see where he's at, but more than likely I will put him out there some," Skiles said. "He knows everything we're doing. We've put in some different offensive things.
"He's been standing on the side watching, but he went right in and ran them (the plays) today. He has the ability to do that. I'm certainly not going to overplay him or anything tonight. But I would like to get him in there and get him a little bit of game work, since we only have two games."
Skiles said his starting lineup Saturday would have Brandon Jennings and Mike Dunleavy in the guard spots, Carlos Delfino at small forward, Drew Gooden at power forward and Andrew Bogut at center.
Veteran guard Stephen Jackson did not make the trip. Skiles said Jackson was getting a second opinion on a back injury which has slowed him during training camp.
Mbah a Moute, who signed a four-year, $18.7 million contract with the Bucks earlier this week, said he had not played organized basketball in a whlle. He was not with the team at the start of camp because of his restricted free agent status, and one week ago the Bucks matched an offer sheet from the Denver Nuggets.
Bucks owner and Sen. Herb Kohl helped facilitate the visa process, Mbah a Moute said. "I'm glad I got cleared so I can go back to practice and get back into basketball shape," he said. "It will be good to get back in the mix of things and get back to playing."
Skiles said he hoped to have the Bucks rookies "get their feet wet" and indicated first-round pick Tobias Harris and second-year forward Larry Sanders would be available. Both have not gone through a full practice since suffering dehydration issues following a practice session on Sunday.
"My understanding is they're still being worked on," Skiles said. "They're cleared to play but there may be some sort of restriction on how much they play. I'll be looking forward to, particularly Tobias, getting him into a game and hopefully Darington (Hobson), too.
"Even though it's an exhibition game, it's still your first pro game. It seems to me it's always benefited rookies to at least get them out there a little bit, get any jitters they have out of the way, bang bodies with Kevin Love and some real pro players."
On guard: Jennings drew attention from the Minnesota media after Saturday's shootaround, and he was asked about his comments two years ago when he declared that Spanish guard Ricky Rubio was "all hype."
"I think at the time I was 18, I was young," Jennings said. "Just for me, going against the best point guards in that draft and him not being there (in workouts), I think I was a little bit upset.
"I think that was just the moment. I like to choose my words kindly now. I'm not 18 no more."
Jennings and Rubio will go against each other on an NBA court for the first time Saturday and will meet three times over the next four games, including the MACC Fund game at the Bradley Center on Wednesday and the Bucks' regular-season home opener on Dec. 27.
"I'm excited," Jennings said of Rubio's arrival on the NBA scene. "It's also good for the city (of Minneapolis). Everybody keeps saying superstars don't want to come to the small markets. So for that, I think it's another great thing."
Jennings also said he got to know Timberwolves' draft pick Derrick Williams on the Under Armour tour during the summer. Williams also will be making his Minnesota debut on Saturday after being taken No. 2 overall in the June draft.
"The dude can jump out of the gym and do a lot of great things," Jennings said of the former Arizona forward. "With the tour, it's not really the NBA, so it's hard to say. But flat out, if he's running down the lane and somebody throws it up, somebody better watch their head."
- Bucks, Plumlee agree to four-year, $50 million deal
- Maker named to Vegas summer league second team
- Dekker, Rockets knock off Bucks in Vegas finale
- Giannis, Thanasis get call to service in Greek military
- Bucks face Mavericks in tournament play Wednesday
- Kidd recalls nearly joining Spurs, salutes Duncan
- Maker impresses with his poise off court, play on it
- Bucks Podcast: Gardner & Velazquez discuss summer league and free agency
- Brogdon says NBA pace takes an adjustment
- Giannis' Olympic dream ends in Greece's 66-61 loss to Croatia


text: The seeds of Danish power metal band Iron Fire were planted in the middle of the 1990s, when singer Martin Steene, then of the band Misery, gradually began to exercise more creative control over the band. After leading the group through a few lineup and name changes (it was briefly known as Decades of Darkness), he named it Iron Fire. In the summer of 1998 the new band, taking its cues from the fast yet melodic approach of German power metal bands like Helloween, recorded the... Read more


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by: tmeta.com • 107
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by: tmeta.com • 107
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Notes on a Conversation: Angee Lennard
February 22, 2011 · Print This Article
Guest post by Julia V. Hendrickson
Notes on a Conversation.
With—Angee Lennard (Founder, Director, and President of the Board of Directors at Spudnik Press)
In—my car, driving to a printmaking workshop at the Marwen Foundation in River North
Commenced—on Wednesday, February 9th, 2011, 8:30–9:15am
The moment I mentioned the word "printmaking†when I moved to Chicago, someone told me to visit Spudnik Press. Time and again I was encouraged by friends and new acquaintances alike in the art community to get in touch with Angee Lennard, to ask her questions, and to get involved in the print shop. When I finally met Angee and stopped by Spudnik Press, it dawned on me what the hubbub was all about; Angee is a quietly welcoming person, and her tireless efforts to maintain and promote a community print shop are inspiring. She is an educator who has chosen her cause, and the harder she works, the more those around her are energized to keep up. [Photo credit C.J. Mace, during Art on Track, 2010].
The last year has been a busy one for Angee, and for the Spudnik Press Cooperative community. In January 2010 Angee was the artist-in-residence at AS220, a community print shop in Providence, RI, where she focused on perfecting the art of mezzotint (a 17th century drypoint etching technique). Spudnik also hosted a few of its own artists-in-residence last year; early in the 2010, Lilli Carré made a small suite of illustrative screen prints recalling classical Greek ceramic decoration, as well as boldly colored, hand-printed artist books (one of which was featured in the MCA's January New Chicago Comics exhibition).
Throughout the summer Jessica Taylor Caponigro (who is also an instructor at Spudnik) printed a subtly complex edition of etchings; wallpaper patterns inspired by class differences in George Eliot's Middlemarch (1874). Most recently, Sanya Glisic has finished the 2010 residency program. Her stunning production is an edition that begs for a publisher and wider distribution: over 50 illustrated, hand-screen printed, and hand-bound artist books reinterpreting cautionary German children's tales from Der Struwwelpeter (1845).
L: Jessica Taylor Caponigro, "Our Vanities Differ" (installation and detail, "Farebrother"), 2010;
R: Sanya Glisic, "Der Struwwelpeter," 2010-11
All of these projects are a testament to a hard-working and supportive print community at Spudnik. Be sure to keep an eye on the residency program, because the newest artist-in-residence is about to get the ball rolling: Dawn Gettler is slated to start printing etchings and a wallpaper installation in March. Other artists who have been utilizing the space include Liz Born, who just finished a series of complex reduction woodcuts called Dimorphisms; comic artist, book maker, and illustrator Edie Fake, who is printing the Chicago Zine Fest poster (which takes place on March 25th-26th); and Stan Shellabarger, who is creating a second "walking book.â€
Future printmakers are bound to have a very different experience of Spudnik, however, because over the next few weeks, Spudnik is rapidly expanding. The shop began in 2007 in Angee's Ukrainian Village apartment, and in 2008 (in order to make it a more egalitarian space), Spudnik moved to the third floor of the 1821 W. Hubbard building. Now, over three years later, Spudnik's rapid expansion warrants another new space. It's just down the hall, but it's much bigger, and the exciting part is that it means the shop can now offer letterpress and offset printing.
Spudnik Press' former studios spaces in 2007 (left) and 2008-2010 (right). Images from Flickr.
A peek at Spudnik Press in 2011 (under construction)
Fund raising (under the tag line, "Space Race: an epic mission to expand the boundaries of community printmakingâ€) is currently under way through the $50 membership program and the $250 subscription program (limited and exclusive access to Spudnik published prints throughout the year). Angee and the other board members hope to keep the shop sustainable by taking commissions and publishing editions for artists who don't typically work in print.
Coming up this weekend is the Hashbrown, an annual fun-fund raiser and celebration. You can catch a glimpse of all the Spudnik activity at 1821 W. Hubbard St, #302 this Saturday, February 26th, from 7:00-10:00pm. Tensions are already high surrounding the printmaker's chili cook-off, so be prepared to witness a little friendly competition. Representatives from One Horse Press, Screwball, The Post Family, Hummingbird Press, Rar Rar Press, Ork Posters, Anchor Graphics, Jetsah (Dan Grezca), and the student printshops at Columbia College, SAIC, and Harold Washington City College will all vie for the title of chili royalty while helping support Spudnik's efforts to expand into a new studio space.
Julia V. Hendrickson is a native of eastern Ohio who lives and works as a visual artist, writer, and curator in Chicago, Illinois. In 2008 she graduated with a B.A. in Studio Art and a minor in English from The College of Wooster (Wooster, Ohio). Julia is currently the gallery manager at Corbett vs. Dempsey, as well as the office manager and design assistant for Ork Posters. She is a teaching assistant at the Marwen Foundation, an active member of the Chicago Printers Guild, and has taught at Spudnik Press. A freelance art critic and writer for Newcity, Julia also keeps a blog called The Enthusiast, a documentation of the daily things that inspire, intrigue, and inform. She is currently exhibiting at Anchor Graphics (Columbia College Chicago) in a solo show titled FANTASTIC STANZAS, on view through March 26th.
Notes on a Conversation: Mark Pascale
February 21, 2011 · Print This Article
Guest Post by Julia V. Hendrickson
Notes on a Conversation.
With—Mark Pascale (Curator in the Dept. of Prints & Drawings at the Art Institute of Chicago, and Adjunct Professor of Printmedia at SAIC)
In—the Prints & Drawings Study Center
Commenced—on Thursday, February 17th, 2011, 4:15–5:15pm
"It's a dream job. It's great place to work. Even under great pressure, when people are at their most difficult, there is still a lot of love here and we all know it. We give each other a lot of space, there's a tremendous amount of collaboration here, and people supporting everybody when they need the support. I think it's very collegial.â€
— Mark Pascale
In a curious corner of the Art Institute, beyond the lions and the ticket booth; through the first gallery on your left (filled, currently, with John Marin's watercolors); past a large glass door; and adjoining a nondescript long white hallway, lies a room full of natural light and very busy people. Dedicated to public inquiry, the Goldman Study Center in the department of Prints & Drawings is one of this city's quiet treasures. Open to the public by appointment only (available to classes in the mornings and to individual researchers in the afternoons), since the 1940s the department has made available over 80,000 works on paper that are part of the Art Institute's collection. Staffed by hard-working curators, collection managers, researchers, administrators, and interns (as well as its own paper conservation department), the study center serves as a visual library; it offers the rare opportunity to examine a small selection of major works of art in person, without the distancing of glass or display.
However, one of the most invaluable treasures in Prints & Drawings is not actually on paper. It is, in fact, embodied in a living, breathing, wise-cracking person: a curator, Mark Pascale, who is celebrating his 30th year with the Art Institute. I first knocked on Mark's door over two years ago, armed with the brazen assumption that he would meet with me based on a shared love of comic art and his connection to Ohio (he went to graduate school at Ohio State University). Since then, Mark has proved to be an encyclopedically resourceful, tirelessly supportive, always kind mentor and friend.
While visiting the study room last week, we looked at one of my favorite recent departmental acquisitions, a bequest from the estate of Sylvia Sights: a small collection of envelopes and ephemera illustrated by Edward Gorey (who was born in Chicago in 1925). Sylvia Sights and Gorey were childhood friends and Lakeview neighbors. Gorey attended SAIC for one semester in 1943, and after he left Chicago he wrote to Sights frequently. Many of the envelopes are from his time at Harvard (1946-50), and were often sent under fantastic pseudonyms like "Childeric Drool†and addressed to "Fascia Scorch.†You can see more photographs of the collection in an album here.
I asked Mark about print-related shows he is proud of being involved with during his time at the Art Institute. He spoke of the intense research and collaboration that goes into major museum exhibitions:
"Being involved in the Jasper Johns: Gray show [in 2007] was a career changing moment for me. He was an artist that I had admired, as an artist, and I especially had admired his printmaking. It was hugely inspirational and instructive to me. It was a frightening prospect because he's very judgmental, and he is not known for his generosity. But I was asked to join the team and I did. […] That experience, working with James [Rondeau] and Douglas [Druick], Harriet Stratis, Christine Conniff-O'Shea, and Maureen Pskowski, having a cross-departmental experience was fantastic.
The other show that I've done that I'm extremely proud of is the one that was called After the Crash: Picturing the U.S. 1930-1943, which I did [in 2000] in conjunction with a curatorial assistant in photography and the special collections librarian in Ryerson. We incorporated prints, photographs, and texts from the Depression, [about] the Depression.
We used our WPA [Works Progress Administration] and FSA [Farm Security Administration] holdings, and it was based upon my question: 'If so many of the artists who worked for the WPA were urban, why are there so many farm images?' So, [we were asking] whether or not the FSA photographs played any role in what got depicted in printmaking. To some degree we found evidence that it definitely was true, and there were quite a few artists that worked both on the FSA project and the WPA project. […] The crowning moment for that was, even though we didn't get to do a book, we had a panel discussion that was chaired by George Roeder, who created the Visual and Critical Studies area at SAIC (now sadly deceased), and included Studs Terkel, who was still really sharp, he really had his wits about him, and the photo historian and photographer Naomi and Walter Rosenblum, respectively.â€
— Mark Pascale
Mark also collaborates across the city with other museums and galleries. In the mid-1990s Mark was an advisor and catalogue contributor to one of the definitive Chicago print shows, Second Sight: Printmaking in Chicago 1935-1995, a survey exhibition at Northwestern University's Block Museum of Art. When I mentioned that show, he sighed and said, "I wish I could redo it because I've learned a lot more about the history of Chicago printmaking since then. But I covered some of it in the Chicago Stories exhibition.â€
(Chicago Stories is Mark's most recent departmental exhibit from the summer of 2010, an historical survey of local printmaking called Chicago Stories: Prints and H.C. Westermann's 'See America First'. While I served as an intern in the department with Mark, fellow intern Andrew Blackley and I collaborated with him on the research, writing, and exhibition planning for Chicago Stories.)
Although Mark rarely has the time to advise or organize more than one show a year outside of the department, he is often asked to judge exhibitions. This year he selected a members exhibition for the upcoming Southern Graphics Council Tempting Equilibrium conference in St. Louis (March 16th-19th, 2011). At the Art Institute, Mark is currently working on a departmental exhibit showcasing a promised gift of over 100 contemporary drawings from a private Chicago collection. He notes that the museum recently has received a lot of criticism for doing private collection shows, but that it's simply a way to honor and celebrate the major support of private collectors:
"We're often accused of being an island, and we're not. To some people we might be. We don't buy that much art. We spend a lot of time engineering gifts. […] The people who are quick to criticize the museum don't seem to know of the long and distinguished history of giving that Chicago museums enjoy, and don't seem to know that we don't receive much public money. There's a limit to what we can do, and a high expectation for what we put out. My feeling is that they should be excited and happy that this art stays in the city forever.â€
— Mark Pascale
The other big show Mark has been working on for the last few years, scheduled for 2013, is a Martin Puryear retrospective, focusing on Puryear's printmaking processes. Although much of Puryear's early work was destroyed in a fire, Mark has been able to find a number of working and state proofs for his more recent editions. The exhibit will highlight Puryear's etchings from Paulson Bott Press (Berkeley, CA), and a major work from Arion Press (San Francisco, CA): illustrations for Cane, a 1923 novel by Harlem Renaissance writer Jean Toomer.
PASCALE'S PICKS:
Above and beyond his knowledge of modern and contemporary art, Mark also knows a thing or two about good food in the city. At the end of our conversation, Mark humored me with a list of a few of his favorite places to eat out.
"Any opportunity to eat badly, I will accommodate it. I have a very high threshold for people's hot dogs and fries, because it's such a Chicago thing. Chicago-style hot dog joints are not like what I experienced growing up. It's local, and I love local.â€
— Mark Pascale
1.) Hot dog and fries at Gene and Jude's Red Hot Stand (and many other places, but G&J is the best) (2720 River Road, River Grove, IL)
2.) Tom Yum Koong (shrimp soup) and Pad Ped Pla Dook (spicy catfish) at Opart Thai House (4658 North Western Ave., Chicago)
3.) Enchiladas Mole at La Oaxaqueña (3382 North Milwaukee Ave., Chicago)
4.) Bhendi Masala (okra curry) at Hema's Kitchen (2439 W Devon Ave., Chicago) or Udupi Palace (2543 W Devon Ave.)
5.) Hungarian Potato Pancake at Smak Tak (5961 North Elston Ave., Chicago)
6.) Chicken Fatoush Salad at Pita Inn (Skokie, Wheeling, and Glenview, IL)
Julia V. Hendrickson is a native of eastern Ohio who lives and works as a visual artist, writer, and curator in Chicago, Illinois. In 2008 she graduated with a B.A. in Studio Art and a minor in English from The College of Wooster (Wooster, Ohio). Julia is currently the gallery manager at Corbett vs. Dempsey, as well as the office manager and design assistant for Ork Posters. She is a teaching assistant at the Marwen Foundation, an active member of the Chicago Printers Guild, and has taught at Spudnik Press. A freelance art critic and writer for Newcity, Julia also keeps a blog called The Enthusiast, a documentation of the daily things that inspire, intrigue, and inform. She is currently exhibiting at Anchor Graphics (Columbia College Chicago) in a solo show titled FANTASTIC STANZAS, on view through March 26th.
Take-Away Art Gets "Twice Removed"
February 16, 2011 · Print This Article
A few weeks ago, some friends and I attended the opening of Twice Removed: A Survey of Take Away Work at Golden Age. I was excited to see a show entirely dedicated to this concept, a concept that one of my favorite artists, Félix González-Torres, explored throughout his career.
Curator Karly Wildenhaus requested submissions of take away art from the personal collections of individuals, and not surprisingly, she amassed a great set of work hailing from places as far away as London and Antwerp, in addition to more local pieces from Chicago, Minneapolis, and Brooklyn, to name a few. (You can read the full exhibition description here and see additional images from the show.)
I've always been intrigued by the idea of audience participation and multiplicity in art – two ideas which take away art knowingly references, but then pushes to a new level by creating an entirely removable installation.
What's so compelling about the take away object is that audience participation is fundamental to the pieces' meaning as a whole. The viewer, at zero cost, leaves with a multiple, and at the artist's encouragement, is sent out into the world to re-appropriate the object in whatever way they see fit. This element of freedom, and the open-ended nature of the artwork's new life, is both exciting and disruptive to the ways in which people traditionally experience art (i.e. in an institutional setting).
As an integral component of the work, viewers are invited to step into the role of collector, a role traditionally inaccessible to the masses for a variety of reasons. And for this particular moment, the "new collectors†dictate the rules of the game by choosing when, where and how to display their newfound pieces, all the while challenging the idea that increased production (many multiples) devalues artwork both in a market sense and in an ideological sense.
Twice Removed draws attention to all of these issues, bringing together an impressive selection of work from well known artists such as Félix González-Torres, Bruce Nauman and Adrian Piper, while also including the work of lesser known artists such as Rivane Neuenschwander (I'm still regretting not having a chance to see her show at the New Museum this past summer).
Walking through the show, I found myself not necessarily thinking about what it meant for these objects to be literally "twice removed†(initially from the museum or gallery, and then yet again by Karly for the purposes of this show), but instead lost in thought about the period in between – what life was like for the object inside the collector's home. Sure, displaying the work as individual pieces this second time around reinforces the transient nature of take away art, and highlights how insubstantial the materials actually are (candy, postcards, pins, ribbon etc.). But, the pieces I was most drawn to were those that the collector had personalized, imbuing the object with an additional layer of meaning and sentimentality.
One great example came in the form of a homemade candy box. This particular collector visited the Guggenheim numerous times to see Félix González-Torres' piece Untitled ("Public Opinionâ€). Each time he went, he gathered a piece of black licorice candy, and once happy with the quantity accumulated, created a display case for them. I loved seeing the transformation from the original installation to this collector's interpretation, although it definitely made me wish that I hadn't just haphazardly eaten my Félix González-Torres candies.
It's been weeks since I saw the show, and I really haven't stopped thinking about it since. The weather is starting to improve, so make the trek to Golden Age to see Twice Removed before it's over. If for some reason you can't make it, there will be an accompanying website and pamphlet published by Golden Age after the show's run.
Elizabeth Corr received a bachelor's degree in Psychology and a master's degree in African Studies from the University of Illinois at Urbana-Champaign. Her graduate work focused on contemporary African art in post-apartheid South Africa. She lives in Chicago and works at NRDC, an environmental nonprofit.
Ray Noland's Urban Fairway
November 15, 2010 · Print This Article
Guest post by Elizabeth Corr
There has certainly been no lack of political drama in Chicago over the past two years. Starting in November 2008, with the historical election of Barack Obama, a wave of excitement and pride swept through the city. This atmosphere proved to be short lived.
It wasn't long until Mayor Daley leased Chicago's parking meters to a private company in an attempt to account for a massive city budget deficit. The public was outraged over increased rates and the quickness with which the deal went down. A few months later, then-Governor Rod Blagojevich was indicted over his alleged attempt to sell Obama's soon-to-be-vacant Senate seat.
Things were going swimmingly, when Chicago was the first city eliminated from 2016 Olympic battle. And then, the icing on the cake for the Mayor's political legacy: In June 2010, the U.S. Supreme Court officially overturned Chicago's handgun ban. Just prior to the ruling, an infuriated Daley, in a now infamous outburst, challenged a reporter's question regarding the effectiveness of the ban. Daley picked up a bayonet at the press conference from a slew of seized guns in Chicago police custody and said, "If I put this up your butt, you'll find out how effective it is.†A mere three months later, Chicago was rocked by the announcement that Daley wouldn't be seeking a 7th term as Mayor of Chicago.
These political developments have provided excessive fodder for pundits, comedians and perhaps most interestingly, artists. In Chicago, Ray Noland has been pioneering the visual response with his fantastic graffiti art. Noland operates the Creative Rescue Organization (CRO) and works under the same name. During the 2008 election, he gained national attention with his street art campaign "Go Tell Mama!†His striking images appeared throughout Chicago streets and alleyways. The concept was particularly interesting because of its contemporary, urban aesthetic, which proudly defied traditional campaign propaganda and stood apart from the graffiti most of us are used to seeing.
It was the beginning of a love affair with politics for CRO, who quickly followed up that series with "Run, Blago Run!†As the embattled former Governor of Illinois pleaded his case on national television, his image started popping up all over the Chicago's buildings and alleys and sure enough, CRO began garnering more and more attention.
CRO hasn't skipped a beat, and since the announcement that Daley won't be running for reelection, graffiti images of the Mayor golfing have started to adorn vacant lots and alleyways throughout Chicago. The graffiti images of the Mayor are instantly recognizable, done in the same precise stenciling style as the Obama and Blagojevich pieces. The latest CRO endeavor, however, far surpasses the previous for one brilliant reason. Until now, CRO's imagery hasn't attempted to critique policy initiatives or laws. For the most part, the work has been lighthearted, satirical and just plain funny commentary on current political affairs.
CRO's Mayor Daley graffiti is particularly effective as street art not just for its aesthetic simplicity, but also because it takes one of the Mayor's signature political policies and flips it on its head, creating an added element of irony – the Mayor as graffiti – the Mayor, seemingly breaking the exact laws he enacted.
Way back in 1992, as an attempt to combat what was perceived as an increase of graffiti within the city, Chicago banned the sale of spray paint to private citizens within city limits. Sales were to be made only to government agencies, public utilities, and contractors. It wasn't until 1995 however, that the ban was actually enforced thanks to a ruling by Justice John Paul Stevens. A year after the spray paint ban was introduced, the Mayor established the Graffiti Blasters – a free graffiti removal service run by the Department of Streets & Sanitation, a service estimated to cost anywhere from 4 million to almost 8 million dollars annually.
In certain neighborhoods of the city, the Graffiti Blasters are ubiquitous. The trucks were all over my Wicker Park/Bucktown neighborhood as the 2016 Olympic committee was preparing its visit. Not a coincidence I'm sure. In fact, it's gotten to the point now where I can't even say the phrase "graffiti blasters†without finding myself humming along to an updated version of the Ghostbusters theme song.
If there's somethin' strange in your neighborhood
Who ya gonna call (graffiti blasters)
If it's somethin' weird an it won't look good
Who ya gonna call (graffiti blasters)
For those not familiar with one of the Mayor's oldest initiatives, it works like this. There are blaster trucks and paint trucks. The blasters remove graffiti from brick and stone surfaces, utilizing a pressurized mixture of baking soda and water to BLAST that graffiti away. The painters, in the most horrible color of brown paint imaginable, cover graffiti on metal, wood and even fabric based surfaces. According to the blaster website (where you can also watch blasters in action) "Graffiti is vandalism, it scars the community, hurts property values and diminishes our quality of life.â€
And this is the heart of the problem with the Mayor's initiative. Its infantile definition of graffiti makes no distinction between actual vandalism and street art. Instead, any act involving spray paint is automatically lumped into a category stripping it of conceptual value and artistic merit. It's been refreshing to see this argument played out in the streets of Chicago with the Mayor as primary subject. As I watch him golfing from my apartment, I often wonder if he's aware of his stenciled avatar, a legacy I'm sure he never expected to leave behind.
Perhaps due to the increasing popularity of his images, CRO is launching a new street endeavor called the [ASC] Project (check out the CRO's Tumblr page for details) – an approved stencil campaign. Business and property owners interested in transforming their surroundings can contact CRO and for no charge, they will transform your surroundings using stencils of their choosing. This is an interesting and unexpected partnership between property owners and graffiti artists, one that I hope might help Chicago's new Mayor better understand the distinction between graffiti as vandalism versus graffiti as street art.
As Chicago contemplates what a future without Daley might look like, CRO is already offering one such possibility….
Elizabeth Corr received a bachelor's degree in Psychology and a master's degree in African Studies from the University of Illinois at Urbana-Champaign. Her graduate work focused on contemporary African art in post-apartheid South Africa. She lives in Chicago and works at NRDC, an environmental nonprofit.
Center Field on art:21 blog: Interview with Derek Chan
October 26, 2010 · Print This Article
Our latest post for our Center Field column on art:21 blog is up! This week, Martine Syms talks to Derek Chan, whose 12 x 12 exhibition at the Museum of Contemporary Art Chicago opens on November 6th. A brief excerpt:
Derek Chan and I have been friends for a little over four years. We both moved from Los Angeles to Chicago in the Fall of 2005. We had several mutual friends and emailed back and forth a few times but never met up. I spent that summer in Los Angeles and unknowingly started talking to Derek at a party. Inevitably, our conversation turned to Chicago and I laughed when I realized that this was the guy I'd had so much trouble making time for. Since then we've stayed close, meeting often to check in with each other, share food, and hang out.
One of Derek's large abstract landscapes, Eclipse, was stored at my house for a year. I was happy to look at it every day. While works like Eclipse captured autobiographical moments with grand gestures, Derek has since focused his attention on the quotidian. During his residency at Theaster Gates' Dorchester Project in South Chicago, Derek began making daily ink drawings to document his thoughts and share them with his fellow residents. All 260 images are available for download on Derek's website. As part of the Whitney Biennial, Derek presented Being/Becoming, a durational performance that included ink drawings and temporary interventions to the Whitney's courtyard. Derek developed a system of marks, influenced by Tibetan rituals, to record the passage of time and his interactions with museum visitors.
Cries and Whispers from the Salt Song Trail is a continuation of this practice. This forthcoming book chronicles his recent journey to the Four Corners region of Arizona through drawings and writings about the sacred places he visited. Golden Age, the project space I run in Chicago, is publishing Cries and Whispers in conjunction with Derek's upcoming exhibition Derek Chan: A Way of Life at the Museum of Contemporary Art Chicago (November 6 – 28, 2010). Continue reading.


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