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user emini's Blog -
Thu, May 31st - 1:10AM
The Discipline It Requires To Be An Emini Trader
Trading emini contracts requires discipline. What decides your success in emini trading is your discipline in trading. Trading eminis is not gambling. In fact, not successful trading is about gambling. Many people seem to believe that trading emini futures contracts is like �gambling� simply because it can involve what is known as �day trading�. However, day traders who have become successful do not approach trading like gambling.
Yes, trading emini futures contracts can yield short term profits, and that�s very largely what makes these contracts so appealing to people who want to trade. Nevertheless, what the whole discipline involving these trades is really about isn�t profits. It�s wanting to learn more and more, each and every day, about how to be a better trader.
It is almost the same as running your own business selling products. Profits may be the first and foremost priority for the business owner, but what must he do in order to get those profits? He must be able to master his business and provide consumers with items that they want. His bottom line may be profits (as it should be), but the bottom line is knowledge. Knowledge coupled with discipline.
Profiting from emini trading is simply about gaining the necessary knowledge to trade productively. Not �perfectly� (without any losses, ever) because that�s impossible. Literally. Successfully trading for profits means that you are making more money in a consistent manner than the one that you have lost. You may encounter losses, however, if your profits outweigh the losses, then in the long run, those losses wouldn�t matter anymore.
In order for an emini trader to become successful, there are techniques and strategies that he has to learn. One strategy that is not included is shooting from the hip. Too many emini traders fall into this pattern. In fact, over 90% of emini traders lose money. This happens because they get swallowed by the idea of making profits and the thrill of thinking of it as a gamble. Knowledge don�t interest them. They care only about the money to be made, like an incompetent businessman who doesn�t think his product quality matters as long as he has a few silver-tongued salesmen who can purportedly sell ice cubes to Eskimos. With emini trading, knowledge is power. In fact, it�s magic. In fact, it�s the only magic that can make for those coveted profits.
For the traders who are willing to gain knowledge, emini profits are not only possible, they can even be expected...after due practice time is put in. Practice is one of the most important ways that you will gain emini trading knowledge. The question is, how will you be able to do that without having to initially lose a lot of money to the point that you can no longer afford to practice? You can do it with the use of today�s virtual trading accounts. This is like playing electronic Monopoly. In this, both the money that you risk and the profits that you make are not real. But an electronic trading account is linked to the real trading world, and therefore it shows you the real world results that you would have gotten if you had opened up a real account and risked real money.
Aside from using an electronic virtual account prior to engaging in emini trading, finding a mentor is equally important. This means that you learn and study what profitable traders do and know. Study, practice. Sound familiar? It is the way to be successful with emini trading, just like in everything else. If you want to try to make $6 million or more gambling, take a trip to Las Vegas or Atlantic City. Don�t consider trading.
Read more here about emini trading
Sun, Apr 22nd - 10:01PM
Techincal Indicators And Emini Trading Fundamentals
For success with emini trading (and success is what means �profits�, after all), you need to be different than at least 90% of all other emini traders. That�s simply a distressing but true fact of the emini trading life. How can you manage to be so different? To put it very simply, you need to learn how to use technical indicators to guide your decision making.
Now, a technical indicator consists of a data point series derived through the application of a formula based on the price data of the underlying security. These price data may include any mixture of the "open", "close", "high", or "low" prices within a given length of time. There are indicators which utilize only the closing prices, just as there are others which incorporate volume and open interest within the formulas. The bottom line for you as an emini trader is that when the price data are entered into the formula, a data point is engendered.
Does that sound a little complex? Well, it is a little complex, but just in case you�re not all that enraptured by mathematics, know that the bottom line for you is that by understanding how to strategically use technical indicators to place emini trade orders, even if they seem to be a little baffling technically, you will become a profitable trader. Moving averages and stochastics are among the most widely used technical indicators for emini futures traders. When you study technical indicators like these, and when you then practice with them with your �paper trading� (that is, electronic demo) account, you become proficient enough with them that you can start making consistent profitable trades.
You may also wonder how knowledge of technical indicators can benefit you� A technical indicator sometimes functions as an indication to you to keep track of price action with additional scrutiny. You may want to look out for a support break whenever there is a waning momentum. The same goes, where you need to look out for a resistance breakout if you notice a large positive divergence mounting.
Technical indicators could serve as confirmation for other tools on technical analysis. You can look to a crossover point to confirm the breakout when there is a price chart breakout and you are utilizing a moving average indicator. When an underlying asset's price breaks support, if you happen to be knowledgeable of On-Balance-Volume (OBV) indicators, you are very likely to be able to verify the weakness, and come up with a trading decision appropriately.
Basically, technical indicators are used by emini traders to predict future price vectors.
What this all signifies for you as an emini trader is that your analysis of a technical indicator is to be carried out with the price action under consideration. So, you need to ask yourself what the indicator is saying in relation to the price action of the underlying asset that is the foundation of your emini contract. Is that price action growing stronger, or is it getting weaker, or is there hardly something of importance happening at the moment?
The best way to gain sufficient expertise with technical indicators is simply to limit yourself to trading just one emini contract at a time when you first begin the practice. Don�t rush in where angels fear to tread with multiple contracts before you�ve proven yourself with consistency on just one. The profits will come in due time, as long as you understand that it is better to be safe than sorry.
If you are looking for part time or fulltime cash,
is an idea you might want to check into.
Emini trading strategies
deliver convenience and flexibility, and features the potential to earn you a lot of income.
Mon, Mar 12th - 5:20AM
Retail Day Trading - A Worthwhile Venture
There are two kinds of day traders; institutional and retail. For many years, institutional was the most popular kind. Recently, thanks to its many benefits and flexibility, retail day trading has become much more popular.
Institutional day traders work for financial institutions. The edge of working for an institution is that you usually have more formal trading education and many more resources, knowledge, and tools made available to you at work. The equipment available is much more costly since it is paid for with the institution's money. These are all great benefits, but nothing beats the versatility of a retail day trader.
Retail day traders work for themselves, either from home or from an office that they have put up. Working for yourself has its apparent advantages. You are your own boss, you are on your own schedule, and you do not have the pressure of a boss always behind you, watching what you are working on. Since having your own computer and an internet connection is so typical and easy to get today, it is easy to put to practice your trading methods right from your home. With a fast connection you can smoothly carry out your job and earn money without leaving the house. With a laptop you can take your computer with you and work from any area.
Some individuals may not think that they would be able to take advantage of working from home by day trading since they do not know the skills. However, with a trading course and some experience you can learn about all the tools of the trade and prepare yourself for a job as a retail day trader.
Besides learning about systems and tools, it is essential to know exactly how the market works. Having an inside knowledge of the system is important since numbers move fast and you have to be able to stay on top of it all in order to do your job properly and earn money. By the time you are done with the course you will have as much of an advantage and knowledge as institutional day traders working in an institution have.
When you're on the lookout for part time or full time cash,
is an alternative you might want to consider.
Emini trading strategies
present convenience and flexibility, and has the opportunity to earn you a great deal of profit.
Wed, Feb 29th - 6:46PM
Day Trading� s Ups And Downs
Just like with every other job in existence today, there are also advantages and disadvantages that you should know about in emini day trading. If the job highly fits you, then you would surely enjoy the benefits, and in fact, you would also find it easy to handle the disadvantages relating to the job.
If you think this might be the career for you, you should be mindful of the advantages and disadvantages of the job. In addition to understanding these basics, you should definitely take a day trading course where you can learn all the trading methods, skills, and techniques you will need in order to get going. For now, here is an idea of some of the positives and negatives of the job before you get started.
� You do not need to have as much money to get started as you do for institutional trading. As opposed to the $25,000 you need for that, you will only need about $3,500 - $5,000. This is a lot more doable, and if you do it right, you will be making that money back, plus more.
� You will not only make money when the market is going up, which is what most individuals think. On the other hand, you can actually make money whether the market is going to the side, down, or up. There are various techniques to learn depending on which way the market is going, so that you can benefit no matter what.
� Unlike in the stock market and with institutional traders, the fast pace of the market is a good thing here. However, in order to take full advantage of the quick ups and downs, a good trader must stay on top of the numbers closely.
� This allows you to work wherever you want to, whether from an office that you have set up, from home, or from a vacation. All you need is your computer and a fast and secure internet connection and you are ready to go, meaning you do not need to spend much money in setting up your office area. You can simply move around and be your own boss. For instance, you do not need to pass up work in order to go on vacation; you can do both.
The only negative aspect to day trading is not having the correct mindset and personality. The job can be stressful, and sometimes brutal, and you simply need to deal with it. You need to think and act quickly, have that great energy, and be able to handle losses. If you have the right emotional stability and the correct mindset, then for sure you could become prosperous in this field.
Before you jump into such a career, try to think upon these pros and cons, so that you may properly decide whether it is the right move for you.
Numerous investors are adding
Emini trading
to their investment mainly because of the convenience and trading income potential the Emini markets have to offer. If you were thinking of buying into
, also consider investing in your day trading schooling in order to prevent irregular trading returns or even a loss in your investment funding as well as your self respect.
Thu, Feb 9th - 3:27PM
The Pros Of Online Futures Trading Are Obvious
Day trading futures has a number of advantages, which is why more and more people are getting involved. The benefits are conducive to many people�s lifestyles, creating a great opportunity for them. Aside from control, convenience, affordability and flexibility, there are still other advantages provided by online trading such as:
Faster results: Day trading works just as the name suggests. You will be able to see results immediately because everything is finished within the day. There is no going to sleep worrying about how the stock is performing over night, because it will not affect your trades, since they are already finished for the day. The difference between short-term results and long-term results is that each day the revenue is not very big. However, if you trade everyday then it adds up to a lot.
Getting faster results also means that you would be able to discover your mistakes right away, learn from them, and correct them the soonest. If you end up losing money one day, you can look over your actions to ascertain what you could have done better. The very next day you can change your trading methods to avoid the same mistake and hopefully make a profit.
Security: One of the benefits of day trading is being able to trade from the comfort and the safety of your own home. Another way to protect your personal information from being at risk online is by installing security software on your pc. This way you can ensure that the information you are sharing online is safeguarded and secure.
Accessibility to newcomers: If you know nothing about trading but are serious in learning more, the thought of starting up could be overwhelming. The truth is, you do not want to jump into trading without understanding what you are doing because the result could be the loss of a lot of money. Luckily, there are plenty of good day trading courses and books that can provide you with a solid foundation to work off of. An excellent course will provide you with all the tools, skills, and knowledge you need to be successful. They will also provide you with practice, such as paper trading, which is trading without the financial commitment.
Trading online has a lot of positive aspects to take advantage of, and can be very profitable if done correctly.
When you're on the lookout for part time or full-time cash flow,
daytrading could be an idea you may want to explore.
Emini trading
tactics offer convenience and flexibility, and has the potential to help you to earn a lot of profit. Trading eminis has become more and more popular as either a part time or a full time career.
May 2012
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You can also use the calendar to search for events to attend in your local area and may like to take inspiration from the ideas on our 'Get involved' page.
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10 Packs, Shipping on Monday! Get your order in for St Patricks Day cigars. Only 3,000 boxes have been manufactured. The annual release of the new Alec Bradley Black Market Filthy Hooligan cigar is always much anticipated, especially as St Patty's Day approaches. This year the 2017 Hooligan maintains the exciting twist of a Barber Pole edition. It's a Black Market Toro with a candela barber pole wrapper. The terrific new green box design is an update to reflect the barber pole on the wrapper, with just 3,000 boxes being produced in advance of St. Patrick's Day, these will all absolutely sell out as they do every year.
So get your order in for the Alec Bradley Black Market Filthy Hooligan 2017 Barber Pole cigars now. As always available for Worldwide delivery.


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The cafeteria on the former Williston High School campus is up for grabs after Williston City Council voted unanimously Tuesday to not enter into negotiations for its purchase.
The decision came early on in the discussions as City Manager Scott Lippmann told council, "There are issues with the cafeteria."
Lippmann said it would be difficult to expand the building should the city need to at a future date, and there are concerns about storm water and drainage.
Only 30 people have sought out shelter at the three schools, Williston High and Bronson and Chiefland Elementaries, leading to officials' concerns that many people may be in danger from a predicted 11-foot surge at 3 a.m. when high tide arrives in Cedar Key.
A mandatory evacuation is being ordered for Cedar Key, Yankeetown and other coastal areas of Levy County this morning (Thursday, Sept. 1) and areas along the Suwannee River.
A shelter of last resort at the old Williston High School Cafeteria located at 427 West Noble Avenue (on US 27).
This is Williston's plan for the future. Questions or comments should be directed to city hall at (352) 528-3060.
By Ashley Andresen
Contributing Writer
Levy County Judge James "Tim" Browning was the guest speaker at the Suwannee Valley Rotary Club on June 23 and while he spoke on the serious topic of the death penalty in Florida being in a state of flux, he also chose to share a personal experience – a "let me tell you what happened to me story."
If you have not voted yet, get moving.
While more than 3,100 people have cast ballots as of Tuesday, one week before the actual primary election day of Aug. 30, it may not be enough.
Levy County Supervisor of Elections Tammy Jones said she is hoping for a 40 percent voter turnout.
The search for Chiefland Mayor Teal Pomeroy, who went diving alone on Friday afternoon, ended sadly with the recovery of his body on Sunday morning. Throughout the weekend the community prayed for a better ending for the husband and father of two young boys.
On Monday, the family announced plans for the funeral on Saturday, August 27, at 4 p.m. at First Baptist Church of Chiefland. There will be a visitation from 2:30 to 4 p.m.
By Carolyn Ten Broeck
After months of discussions and two extended workshops where residents were encouraged to add their ideas, the report for the future of Williston was unveiled last week to the city council.
Professional facilitator Marilyn Crotty summarized what both council and residents brainstormed and put it into a report listing goals and objectives.
Topping that list is the goal to develop a new city hall.
Copyright © 2017
The Williston Pioneer is your source for local news, sports, events, and information in Levy County and Williston, Fl, and the surrounding area.


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Brookfield Academy
Thirty-six students from the Lower School, Middle School and High School attended the State Concours Oral, a French forensic-style competition, and earned 34 gold medals and two silver medals. French has been part of the Brookfield Academy curriculum since the school's founding in 1962. Students continue to excel in Spanish, German and Latin as well.
Brookfield Central
Brookfield Central sold doughnuts and discounted movie tickets to students to raise money for its Project Graduation, which will fund activities for students about to graduate.
Brookfield Christian
Brookfield Christian School third-grade classes presented a Living Wax Museum for parents and friends. The students came to school dressed as a famous person from history to share their projects, timelines and creativity with others. Parents, family, friends and students discovered that the statuelike person would come to life if they pressed the designated button. By pressing the button, a short speech was recited as third-graders "came to life," describing what it was like to be someone from the past.
Brookfield East
The 18th annual Rockets for Schools event was held at the Spaceport in Sheboygan the weekend of May 2. Heather Paul, an engineer from NASA's Johnson Space Center, spoke to Brookfield East students, and a launch was held Saturday, May 3. The BEHS team placed second out of 16 teams from four states.
Brookfield Elementary
Second-grade Girl Scout Troop 8004 planted a baby Colorado spruce on the berm along the playgound sidewalk of the elementary school earlier this month.
Burleigh Elementary
Burleigh fifth-graders "time-traveled" to the colonial days on May 16. After learning about the time period, students wore colonial-style clothing and re-enacted the lives of other students in the past.
Dixon Elementary
Dixon's Cancer Walk this year will raise money in support of breast cancer patients and in memory of fifth-grade teacher Angie Malett, who died in April. The Cancer Walk will be held May 30.
Elm Grove Lutheran
After the end of the third quarter, the following students were selected for the Principal's Honor Roll: fifth-graders Jamie Krueger, Grady Ma, Cassandra Romero; sixth-grader Samuel Ewert; seventh-graders Emily Ewert, Callie Hedtke, Joshua Hetcher, Connor Hipke, Owen Krueger, Angela Lee; and eighth-graders Margaret Halvorson, Cate Heup, Alexis Roimero, Megan Stritesky and Joshua Zhang.
To submit information, email firstname.lastname@example.com. Items are due one week before publication.
- In Our Schools: June 9
- Brookfield and Elm Grove In Our Schools: May 26
- Broookfield and Elm Grove In Our Schools: May 19
- Brookfield/Elm Grove In Our Schools: May 5
- Brookfield-Elm Grove In Our Schools: April 28
- In Our Schools: April 21
- In Our Schools: April 14
- In Our Schools: April 7
- Brookfield and Elm Grove In Our Schools: March 24
- In Our Schools: March 17
- Brookfield and Elm Grove In Our Schools: March 10
- Brookfield and Elm Grove In Our Schools: March 3
- In Our Schools: Feb. 25
- In Our Schools: Feb 11
- Brookfield and Elm Grove In Our Schools: Feb. 4
- In Our Schools: Jan. 28
- In Our Schools: Jan. 21
- In Our Schools: Jan 14
- In Our Schools: Dec. 24
- In Our Schools: Dec. 10


text: Back by popular demand, following sell-out performances last year, Slava's Snowshow returns to the Southbank Centre this Christmas! The multi award winning international sensation, Slava's Snowshow has delighted and thrilled audiences in over 80 cities around the globe including New York, Los Angeles, Paris, Rome, Hong Kong, Rio de Janeiro and Moscow. 'Pure magic. An evening of enchantment and fun' Daily Express 'Unmissable' The Times 'Simply thrilling' The Independent Experience a joyous dream-like world which will touch both your heart and funny bone, culminating in a breathtaking blizzard leaving you literally knee deep in snow! Book your Slava's Snowshow tickets today!


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Comment CRT Burn in is now LCD Retina Glacouma (Score 1) 195
Old CRTs had burn in because they were steadily being zapped with electricity, how does an LCD have burn in? I can't seem to figure it out. They need a diferent term. Since it is a retina display, how about glacouma?


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The Quintessence of English Poetry, Or, a Collection of All the Beautiful Passages in Our Poems and Plays, from the Celebrated Spencer to 1688 ...
Olive Payne, 1740 - English poetry
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aster b'ing Barons Wars Beaumont and Fletcher's besore blood body breast Catiline Chapman's chast Crown's Daniel's dare Davenant's death deeds Devil doth earth ev'n ev'ry eyes give glory Gondibert gries griess hath heart heav'n Henry Henry VII hersels himsels honour humour Ibid itsels John Ford's Johnson's Julius C�sar king lise live Lord Brooke's lust man's mind Mirror for Magistrates nature ne'er never ossice passion persect pleasure poor pow'r praise pride princes reason revenge Revenger's Tragedy ruin sace saith sall salse sase sashion sate sather scorn sear Sejanus sels sev'ral Shakespear's shew Shirley's sield sight sire sirst sollow sools sorce sorm sorrow sorth sortune soul spirits sree sriends srom sweet thee theresore things thou thought tongue true truth tyrants unto valour vertue Vestal Virgin virgin virtue Webster's Whilst White Devil wise woman women
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Page 309 - And new philosophy calls all in doubt; The element of fire is quite put out; The sun is lost, and th' earth, and no man's wit Can well direct him where to look for it.
Page 199 - Though I look old, yet I am strong and lusty: For in my youth I never did apply Hot and rebellious liquors in my blood; Nor did not with unbashful forehead woo The means of weakness and debility; Therefore my age is as a lusty winter, Frosty, but kindly: let me go with you; I'll do the service of a younger man In all your business and necessities.
Page 22 - Speak the speech, I pray you, as I pronounced it to you, trippingly on the tongue : but if you mouth it, as many of our players do, I had as lief the town-crier spoke my lines.
Page 88 - I know you all, and will awhile uphold The unyok'd humour of your idleness ; Yet herein will I imitate the sun, Who doth permit the base contagious clouds To smother up his beauty from the world, That when he please again to be himself, Being wanted, he may be more wonder'd at, By breaking through the foul and ugly mists Of vapours that did seem to strangle him.
Page 19 - Perseverance, dear my lord, Keeps honour bright : To have done, is to hang Quite out of fashion, like a rusty mail In monumental mockery.
Page 43 - Even to the teeth and forehead of our faults To give in evidence. What then? what rests? Try what repentance can: what can it not? Yet what can it, when one can not repent? O wretched state! O bosom black as death! O limed soul, that struggling to be free Art more engaged! Help, angels! make assay; Bow, stubborn knees; and heart with strings of steel Be soft as sinews of the new-born babe. All may be well.
Page 104 - Mongst quiet kindred that had nothing left By their dead parents : ' Stay,' quoth Reputation, ' Do not forsake me ; for it is my nature, If once I part from any man I meet, I am never found again.
Page 114 - Now might I do it, pat, now he is praying; And now I'll do't...
Page 21 - What's Hecuba to him, or he to Hecuba, That he should weep for her/ What would he do, Had he the motive and the cue for passion That I have...
Page 105 - A real, or at least, a seeming good. Who fears not to do ill, yet fears the name, And, free from conscience, is a slave to fame. Thus he the church at once protects and spoils ; But princes' swords are sharper than their styles : And thus to th' ages past he makes amends, Their charity destroys, their faith defends.


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Dennis Hissink : October 31th 2006 - 22:30 CET
Sony Cybershot T50 limited edition
Sony Cybershot T50 limited edition :
Sony is offering movie fans and gadget-lovers an opportunity to gear-up like Bond with Sony's exclusive Bond Collection products in anticipation of the upcoming James Bond film Casino Royale, which will be released worldwide on November 17, 2006 from Columbia Pictures and Metro-Goldwyn-Mayer Studios. The collection, available exclusively on sonystyle.com/casinoroyale and in Sony Style retail stores across the country, features limited-edition 007-branded models of VAIO TX and UX series PCs, Sony T50 and Micro-Vault storage devices. All of these products will feature the 007 logo and the VAIO PCs will come pre-loaded with exclusive Casino Royale content, such as wallpapers and screensavers.
Sony T50 - Special production model
Each limited production 007 model is numbered and comes with a certificate of authenticity. "Both James Bond and Sony have always provided a cool-factor that consumers have grown to love," said Hiro Kawano, Sony Electronics' Senior Vice President for Sony Style. "We are excited to be able to offer these collector's items exclusively through Sony Style.' The Bond Collection will be available starting November 10, with pre-orders currently available on Sonystyle.com/casinoroyale.
Sony Style shop - Casino prizes
To take the Bond experience to the next level, consumers can try their hands at one of four Sony-product branded casino games at sony.com/casinoroyale. Players can choose from BRAVIA Blackjack, VAIO/Intel poker, Cyber-shot T-50 slots or Blu-ray Disc roulette. Now through Nov. 17, participants with a winning hand receive a printable game chip, redeemable at participating retailers, including Sony Style, for a chance to win prizes, including a $50,000 Sony merchandise prize package, a $5,000 shopping spree, and a weekend getaway for two. Not only can you gear up like Bond, you can play like him too.
Sony Cybershot T50 compact camera - Price
The Bond Collection products can be purchased as a bundle which includes a choice of either the VAIO VGN-UX007 along with 007 Cyber-shot DSC-T50 and a 1GB Micro Vault for approximately $3,200 or the VAIO VGN-TX007 with the Cyber-shot DSC-T50 and 1 GB MicroVault for approximately $3,900. The bundles come with an aluminum attaché carrying case and a James Bond welcome kit. The Sony 007 Cybershot DSC-T50 and the Micro Vault can be purchased individually for approximately $600 and $60, respectively.
007 James bond accessories - Digital camera
Daniel Craig stars as "007" James Bond, the smoothest, sexiest, most lethal agent on Her Majesty's Secret Service in Casino Royale. Based on the first Bond book written by Ian Fleming, the story recounts the making of the world's greatest secret agent. Martin Campbell is directing the 21st adventure in the 44-year-old franchise, from a screenplay by Neal Purvis & Robert Wade and Paul Haggis.
Sony Cyber-shot digital camera - 007 and Bond
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Sony manufactures audio, video, communications and information technology products for the global consumer and professional markets. With its music, pictures, game and online businesses, Sony is uniquely positioned to be one of the World's Leading Consumer Brands. Sony recorded consolidated annual sales of EUR 54.96 billion (yen 7,475 billion) for the fiscal year ended March 31, 2006 and it employs approximately 158,500 people worldwide. In Europe, Sony recorded consolidated annual sales of EUR 12.61 billion (yen 1,715 billion) for the fiscal year ended March 31, 2006, based on an average market exchange rate for the same period of yen 136 to the EUR. Sony Europe, headquartered at the Sony Center am Potsdamer Platz in Berlin, is responsible for the company's European electronics business and registered consolidated sales of EUR 8.22 billion (yen 1,118 billion) for the fiscal year ended March 31, 2006.
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Möchtest du als deine Standardwährung festlegen oder nur für diese Sitzung behalten?
Drury Inn Indianapolis Northwest
9320 North Michigan Road, Indianapolis, IN
0,3 km von
ab 117 €
Zimmer sauber, Hotellangestellte freundlich und hilfsbereit. Umfangreicheres Kontinentales Frühstück gegenüber anderen Hotels. Internetverbindung im Zimmer schlecht bis zeitweise nicht verfügbar. Zimmer sehr laut durch laufende Wasserleitung beim Duschen von Hotelbewohnern in anderen Zimmern.
Friendly Staff...clean linens. Quality Control Team needs to walk through the rooms...several drywall patchwork needs to be done, as well as other cosmetic items like cleaning the blow dryers, the mildew in between the tiles, the handles to the refrigerators, and so forth.
Bed Toilet running all night. Bathtub wasn't draining properly. No garbage in bathroom. Shower was loud. Barely any soap.
Good price room fee and Indianapolis centore 15 min.
The best part was the location - close to the highway. The room was very small and the pictures of the hotel did not do justice to it's poor condition.
The Guys at the front desk were so helpful. The breakfast was great every day and Cindy was always on point with refills and a smile. The hotel is really nicely appointed and we had a great long stay. Fitness room is not in service right now. But Manager Mike said that he's getting it fixed!
Nothing The fact that the sheets were chalky still dirty from the last occupants of the room and that they wouldn't come change the sheets for us.
The price. No working vending machines.
Good value
Room was clean and it was right off the highway by half a dozen good restaurants There were young black adults hanging out in the parking lot with the music blaring. I asked the attendant in the hotel about it and he said that its normal on weekends because of the colleges in the area. I would never have let my wife and kids stay there because of that!
price just the facts - bare minimum facility; recent remodel was mediocre; linoleum floors, no pictures, etc.; it is ok for a place to sleep, and that is all; never a person at the front desk w/o being called; coffee only in the lobby in the morning, not the room; appears to be a remodeled Microtel; not sure I would stay there again w/my wife; probably would stay by myself; price the sole redeeming feature
Though this is definitely a "bare-minimum" hotel in an older building, I could not have been happier with my stay. I was staying in town for a funeral and had to find a place on short notice and, because I was traveling alone, I wanted to stay at a hotel with interior doors to the room. When I arrived I was leery of the old building, but the staff is was incredibly friendly and interacted pleasantly with everyone. There were lots of people there, most of whom seemed to be on short trips. The same two people were at the front the entire time I was there, and when I checked in I was asked why I was traveling. I mentioned that I was in town for a funeral. When I checked out the manager remembered this and asked who I had lost and if I was okay. Overall I was pleasantly surprised, and I would recommend for short stays.
Pool was nice, staff was fantastic.
This guest did not leave comments about this hotel.
The price
Friendly staff Heat did not work properly in room claning staff left the cleaning solution in toilet burned my eyes when i walked in bathroom
This guest did not leave comments about this hotel.
This guest did not leave comments about this hotel.
very clean you rated it a 1 star (roaches crawling on floor) and it's a solid 2 star
The room was/felt large, the bed was soft, the water was always hot when I needed it. The microwave and mini-fridge made snacks easy. The cleaning staff was always helpful, did a good job cleaning/straightening the room, and the breakfast was sufficient. Didn't have C-SPAN. The treadmill needs to be tightened, it's unsafe at jog speed. The wall-paper is old and some stains are obvious. The carpets in some places could use some attention with the shampooer.
This guest did not leave comments about this hotel.
Location! Staff was friendly and nice. TV size and microwave/fridge in room was a bonus Hotel needs an update- Walls scuffed, holes, pictures hung crookedly. Mold was growing in old tub-surround in shower. A built-in cabinet and top is needed for the fridge and microwave. Plug-ins and wall outlets are dated or not working. Clean but dumpy
This guest did not leave comments about this hotel.
The heat didn't work. And you all could let people know about the deposit.
I really like the kindness that the staff showed during our stay, my family and I would stay there again, the next time we come there.
staff was great,breakfast also. satilite tv was the worst i ve ever seen or not seen.`
cleanliness and quiet and cozy atmosphere
The staff was friendly and helpful. Close to shopping and restrauants.
The hotel was clean & well maintained. Continental breakfast selection was limited..
There was nothing I liked. They lost my reservation. They did not honor my discount. The non-smoking room smelt like an ashtray. There was nothing I liked. They lost my reservation. They did not honor my discount. The non-smoking room smelt like an ashtray
Breakfast was good enough. The man who checked us in gave us keys with room nunber written in two different places (key holder envelope and receipt). The numbers were different. When we went to the room (written on the receipt), the keys would not open the door. We went down to the room written on the Key holder, the key opened the room but the room already had luggage in it. The desk clerk had given us someone else's room keys. It would have been scary for them -- if they had been in the room. Certainly is a problem with respect to safety wouldn't you agree. The desk clerk apologized and reissued new keys to us, but it makes you wonder. We could have ran-sacked that other room, while they were out.
It was excellent. We will come back
The hotel overall felt very dirty, there was some sort of what looked like a blood splatter on our ceiling. The hallways had a lot of stains in them and the chlorine smell from the pool was so overwhelming we stayed on the 3rd floor and could smell the chlorine all the way up there. Would not return to this hotel next time I am in Indianapolis.
They need a hottub and hotter water for showers
The price and it had a kitchen. One has to carry their luggage up stairs for the second and third floor. I like this but most people may not.
Location only Dirty, smelled of urine, misrepresented as motel as it appeared to be halfway house for mentally ill
price The room was not very nice.
The staff was very nice, and it was located near many shopping centers and restaurants. The room was not very clean, there was mice feces and papers from back in september on top op the fridge, the toilet would only flush sometimes, the tub had water constantly running, the kitchen was missing a drawer and part of a door.
Dirty towels left from previous occupant. Windows did not lock, so we had to jam it shut for security. Felt dirty just from being in the room. I'll never stay here again, for what we paid, I expected a lot more.
Staff was courteous and friendly. Location is good. Yes, plenty. 1)Free breakfast meant grab a granola bar and coffee. That's not breakfast in my opinion. 2) Rooms are small and only have one queen size bed. There is an upcharge of $10.00 for a sofa bed at the end of the bed.
I was scared I was going to take something home with me.. main desk closed at night they only gave me one key so if my key quit working I wouldn't have been able to get back in.. bathroom smells like urine really bad.. they took a deposit on your credit c Front desk lady was really nice
dated furnishing, bedding, etc. Not so clean bathroom and kitchen. This was not a 2 and 1/2 star hotel. It is a 1 star hotel.
This guest did not leave comments about this hotel.
My entire experience was great staff was very nice rooms was clean great stay
This guest did not leave comments about this hotel.
The staff was amazing! At 35 weeks pregnant I couldn't find an available hotel in the area until a day after I needed it. I ended up having to sleep in my car for a night but spoke to the manager about the situation and they were able to have me a room ready at around 8am instead of the typical 3pm check in time. Very nice of them and very appreciated! The room was very dirty. Typical things that you'd expect to be done weren't.
Breakfast was good. The elevator was broken and I had to walk up and down the steps outside in the rain. My room was on the third floor. No meat in the breakfast.
The staff was very nice. Beds and room were comfortable. I lost my bluetooth headset in my room and informed the front desk clerk if they found it please give me a call and mail it to me. Because everybody isn't so honest these days I had already started counting it a lost. Within 2 hours of my drive back home the clerk called and informed me that they found it and will be mailing it back. I thank God for his honesty. The toilet and tub kept getting stopped up, no garbage can in the room and I had to call the front desk for an iron.


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text:
SDHB loss predicts malignancy in pheochromocytomas/sympathethic paragangliomas, but not through hypoxia signalling
Blank A.,TU Munich |
Blank A.,University of Bern |
Schmitt A.M.,University of Bern |
Korpershoek E.,Rotterdam University |
And 8 more authors.
Endocrine-Related Cancer | Year: 2010
Prediction of malignant behaviour of pheochromocytomas/sympathetic paragangliomas (PCCs/PGLs) is very difficult if not impossible on a histopathological basis. In a familial setting, it is well known that succinate dehydrogenase subunit B (SDHB)-associated PCC/PGL very often metastasise. Recently, absence of SDHB expression as measured through immunohistochemistry was shown to be an excellent indicator of the presence of an SDH germline mutation in PCC/PGL. SDHB loss is believed to lead to tumour formation by activation of hypoxia signals. To clarify the potential use of SDHB immunohistochemistry as a marker of malignancy in PCC/PGL and its association with classic hypoxia signalling we examined SDHB, hypoxia inducible factor-1α (Hif-1α) and its targets CA-9 and GLUT-1 expression on protein level using immunohistochemistry on a tissue micro array on a series of familial and sporadic tumours of 115 patients. Survival data was available for 66 patients. SDHB protein expression was lost in the tumour tissue of 12 of 99 patients. Of those 12 patients, 5 had an SDHB germline mutation, in 4 patients no germline mutation was detected and mutational status remained unknown in parts in 3 patients. Loss of SDHB expression was not associated with increased classic hypoxia signalling as detected by Hif-1α, CA-9 or GLUT-1 staining. Loss of SDHB expression was associated with an adverse outcome. The lack of correlation of SDHB loss with classic hypoxia signals argues against the current hypoxia hypothesis in malignant PCC/PGL. We suggest SDHB protein loss as a marker of adverse outcome both in sporadic and in familial PCC/PGL. © 2010 Society for Endocrinology. Source
MicroRNA expression array identifies novel diagnostic markers for conventional and oncocytic follicular thyroid carcinomas
Dettmer M.,University of Pittsburgh |
Vogetseder A.,University of Zurich |
Durso M.B.,University of Pittsburgh |
Moch H.,University of Zurich |
And 4 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2013
Objective: The most difficult thyroid tumors to be diagnosed by cytology and histology are conventional follicular carcinomas (cFTCs) and oncocytic follicular carcinomas (oFTCs). Several microRNAs (miRNAs) have been previously found to be consistently deregulated in papillary thyroid carcinomas; however, very limited information is available for cFTC and oFTC. The aim of this study was to explore miRNA deregulation and find candidate miRNA markers for follicular carcinomas that can be used diagnostically. Design: Thirty-eight follicular thyroid carcinomas (21 cFTCs, 17 oFTCs) and 10 normal thyroid tissue samples were studied for expression of 381 miRNAs using human microarray assays. Expression of deregulated miRNAs was confirmed by individual RT-PCR assays in all samples. In addition, 11 follicular adenomas, two hyperplastic nodules (HNs), and 19 fine-needle aspiration samples were studied for expression of novel miRNA markers detected in this study. Results: The unsupervised hierarchical clustering analysis demonstrated individual clusters for cFTC and oFTC, indicating the difference in miRNA expression between these tumor types. Both cFTCs and oFTCs showed an up-regulation of miR-182/-183/-221/-222/-125a-3p and a down-regulation of miR-542-5p/-574-3p/-455/-199a. Novel miRNA (miR-885-5p) was found to be strongly up-regulated (>40-fold) in oFTCs but not in cFTCs, follicular adenomas, and HNs. The classification and regression tree algorithm applied to fine-needle aspiration samples demonstrated that three dysregulated miRNAs (miR-885-5p/-221/-574-3p) allowed distinguishing follicular thyroid carcinomas from benign HNs with high accuracy. Conclusions: In this study we demonstrate that different histopathological types of follicular thyroid carcinomas have distinct miRNA expression profiles. MiR-885-5p is highly up-regulated in oncocytic follicular carcinomas and may serve as a diagnostic marker for these tumors. A small set of deregulated miRNAs allows for an accurate discrimination between follicular carcinomas and hyperplastic nodules and can be used diagnostically in fine-needle aspiration biopsies. Copyright © 2013 by The Endocrine Society. Source
News Article
Site: http://www.nature.com/nature/current_issue/
LAP-tTA and TRE-MYC mice were previously described and MYC expression in the liver was activated by removing doxycycline treatment (100 μg ml−1) from the drinking water of 4-week-old double transgenic mice for both TRE-MYC and LAP-tTA as previously described9, 13. C57BL/6 mice were obtained from NCI Frederick. Chemically induced HCC was established by intraperitoneal injection of diethylnitrosoamine (DEN) (Sigma) into 2-week-old male pups at a dose of 20 μg g−1 body weight13. Twelve-week-old male B6.Cg-Lepob/J (ob/ob) mice or wild-type control mice were obtained from Charles River. Foxp3–GFP mice were previously described31. NAFLD was induced by feeding mice with a methionine–choline-deficient (MCD) diet (catalogue number 960439, MP biomedical), a choline-deficient and amino-acid-defined (CDAA) diet (catalogue number 518753, Dyets) or a high-fat diet (catalogue number F3282, Bio Serv) for the indicated time10, 11, 32. The MCD diet was supplied with corn oil (10%, w/w), and no fish oil was added. Control diet was purchased from MP Biomedical (catalogue number 960441). Custom-made high- or low-linoleic-acid mouse diets were purchased from Research Diets. The modified diets were based on AIN-76A standard mouse diet, and are isocaloric (4.45 kcal g−1) and contained the same high-fat content (23%, w/w). Linoleic-acid-rich safflower oil and saturated fatty-acid-containing coconut oil were supplied at different ratios to yield 2% (w/w) for the low-linoleic-acid diet or 12% (w/w) for the high-linoleic-acid diet. C57BL/6 mice were fed with the high- or low-linoleic-acid diet for 4 weeks. MYC mice were injected i.p. with 50 μg CD4 antibody (clone GK1.5, BioXcell) every week for the indicated time period to deplete CD4+ T cells33. N-acetylcysteine (NAC) was given in drinking water (10 mg ml−1)34 for the indicated time period to prevent excess ROS production. Mitochondrial-specific antioxidant mitoTEMPO was purchased from Sigma. Mice received mitoTEMPO at a dose of 0.7 mg kg−1 per day25 by osmotic minipumps (ALZET). At the experimental end points, mice were killed. For flow cytometry analysis, single-cell suspensions were prepared from spleen, liver and blood as described previously. Red blood cells were lysed by ACK Lysis Buffer (Quality Biologicals). Parts of live tissue were fixed by 10% formaldehyde and subjected to H&E staining. Free fatty acids were purchased from Sigma. Lipid accumulation was detected by Oil Red O staining in frozen liver sections using the custom service of Histo Serv. Cells were surface-labelled with the indicated antibodies for 15 min at 4 °C. Flow cytometry was performed on BD FACSCalibur or BD LSRII platforms and results were analysed using FlowJo software version 220.127.116.11 (TreeStar). The following antibodies were used for flow cytometry analysis: anti-CD3-FITC (clone 17A2, BD Pharmingen), anti-CD4-PE (clone RM4–4, Biolegend), anti-CD4-APC (clone RM4–5, eBioscience), anti-CD8-Alexa Fluor 700 (clone 53–6.7 Biolegend), anti-CD45, anti-CD44-PE (clone IM7, eBioscience), anti-CD62L-PerCP/Cy5.5 (MEL-14, Biolegend), anti-CD69-Pacific blue (clone H1.2F3, Biolegend), PBS57/CD1d-tetramer-APC (NIH core facility). To determine cytokine production, cells were stimulated with PMA and ionomycine for 30 min, and then were fixed and permeabilized using cytofix/cytoperm kit (BD Pharmingen) followed by anti-IFN-γ-PE (clone XMG1.2, BD Pharmingen), anti-IL-17-PerCP/Cy5.5 (clone TC11-18H10.1, Biolegend) staining. Cell death and apoptosis were detected with annexin V-PE (BD Pharmingen) and 7-AAD (BD Pharmingen) staining according to the manufacturer's instructions. Intrahepatic CD4+ lymphocytes were gated on the CD3hiCD4+ population from total live hepatic infiltrating mononuclear cells. Absolute numbers were calculated by multiplying frequencies obtained from flow by total live mononuclear cell count, then divided by liver weight. The antibodies used for human peripheral blood mononuclear cell (PBMC) staining are the following: anti-CD3-PE (clone SK7, BD Pharmingen), anti-CD4-FITC (clone RPA-T4, BD Pharmingen), anti-CD8-APC (clone RPA-T8, BD Pharmingen). Murine T assays were performed as described31. Briefly, liver T cells were isolated as CD4+GFP+ by flow-cytometry-assisted cell sorting from Foxp3–GFP mice kept on an MCD or control diet for 4 weeks. CD4+GFP− T effector (T ) cells (5 × 104) were stimulated for 72 h in the presence of irradiated T-depleted splenocytes (5 × 104) plus CD3ε monoclonal antibody (1 μg ml−1), with or without T cells added at different ratios. 3H-Thymidine was added to the culture for the last 6 h and incorporated radioactivity was measured. Freshly isolated splenocytes from MYC-ON MCD mice were incubated with 5 μg ml−1 of mouse α-fetoprotein protein (MyBioSource) for 24 h. Golgiplug was added for the last 6 h. Then, cells were fixed and permeabilized using cytofix/cytoperm kit (BD Pharmingen) followed by anti-IFN-γ-PE (clone XMG1.2, BD Pharmingen) staining. Primary mouse hepatocytes were isolated from MYC mice and cultured according to a previous report35. Briefly, mice were anaesthetized and the portal vein was cannulated under aseptic conditions. The livers were perfused with EGTA solution (5.4 mM KCl, 0.44 mM KH PO , 140 mM NaCl, 0.34 mM Na HPO , 0.5 mM EGTA, 25 mM Tricine, pH 7.2) and Gey's balanced salt solution (Sigma), and digested with 0.075% collagenase solution. The isolated mouse hepatocytes were then cultured with complete RPMI media in collagen-I-coated plates. Hepatic fatty acid composition was measured at LIPID MAPS lipidomics core at the University of California (San Diego) using an esterified and non-esterified (total) fatty acid panel. Briefly, liver tissues were homogenized and lipid fraction was extracted using a modified Bligh Dyer liquid/liquid extraction method. The lipids were saponified and the hydrolysed fatty acids were extracted using a liquid/liquid method. The extracted fatty acids were derivatized using pentaflourylbenzylbromine (PFBB) and analysed by gas chromatography (GC) using an Agilent GC/mass spectrometry (MS) ChemStation. Individual analytes were monitored using selective ion monitoring (SIM). Analytes were monitored by peak area and quantified using the isotope dilution method using a deuterated internal standard and a standard curve. Isolated primary hepatocytes from MYC mice fed with MCD or control diet were cultured in complete RPMI for 24 h. Supernatant were harvested and FFAs were identified by GC/MS. Splenocytes from MYC mice were cultured with or without 50 μM C18:2 for 24 h. CD4+ and CD8+ T lymphocytes were sorted and total RNA was extracted using miRNeasy mini kit (Qiagen). Array analysis was performed in the Department of Transfusion Medicine, clinical centre at NIH. Mouse gene 2.0 ST array (Affymetrix) was used and performed according to the manufacturer's instruction. Data were log-transformed (base 2) for subsequent statistical analysis. The Partek Genomic Suite 6.4 was used for the identification of differentially expressed transcripts. The Ingenuity Pathway Analysis tool (http://www.ingenuity.com) was used for analysis of functional pathways. RNA was extracted from frozen tissues with RNeasyMini Kit (Qiagen). Complementary DNA was synthesized by iScriptcDNA synthesis kit (BioRad). Sequence of primers used for quantitative RT–PCR can be obtained from the authors. The reactions were run in triplicates using iQSYBR green supermix kit (BioRad). The results were normalized to endogenous GAPDH expression levels. CD4+ T lymphocytes were isolated from the spleen of MYC mice by negative autoMACS selection using a CD4+ T lymphocytes isolation kit (Miltenyi Biotec) or flow cytometry cell sorting. Human CD4+ T lymphocytes were prepared from PBMCs by autoMACS using a CD4+ T lymphocytes isolation kit (Miltenyi Biotec). The purity of CD4+ T lymphocytes was above 90% after autoMACS separation and above 95% after flow cytometry cell sorting. C16:0, C18:0, C18:1,and C18:2 were purchased from Sigma. Fatty acids were dissolved in DMEM with 2% fatty-acid-free bovine serum albumin (BSA; Sigma, catalogue number A8806) after solvent was evaporated, then followed by two rounds of vortexing and 30 s of sonication. Isolated CD4+ T lymphocytes or splenocytes were incubated with different fatty acids or conditioned medium from hepatocyte culture for 3 days. Unless specifically described, fatty acids were used at 50 μM concentration. For fatty acid depletion, active charcoal (catalogue number C-170, Fisher) was used as described before36. Briefly, 0.5 g of active charcoal was added into every 10 ml of conditioned medium. Then pH was lowered to 3.0 by addition of 0.2 N HCl. The solution was rotated at 4 °C for 2 h. Charcoal was then removed by centrifugation, and the clarified solution was brought back to pH 7.0 by addition of 0.2 N NaOH. NAC (10 mM), catalase (1,000 U ml−1) or mitoTEMPO (10 μM) was used to inhibit ROS production, mitochondrial ROS levels were determined by mitoSOX staining 24 h after treatment, cell death and apoptosis were measured by annexin V and 7-AAD staining 3 days after treatment. Caspase activity assay was measured by caspase-Glo 3/7 assay kit (Promega) according to the manufacturer's protocol. Fresh prepared liver-infiltrating mononuclear cells were washed and resuspended in 500 μl of BODIPY 493/503 at 0.5 μg ml−1 in PBS. Cells were stained for 15 min at room temperature. Then cells were subjected to flow cytometry analysis. Two pZIP lentiviral shRNA vectors targeting human CPT1a and a control vector (NT#4) were purchased from TransOMIC Technologies. Lentivirus was packed in 293T cells. Jurkat cells were purchased from the German Collection of Microorganisms and Cell Cultures (DSMZ), and no authentication test was performed by us. Cells were cultured in complete RPMI medium and were tested to be mycoplasma free. Jurkat cells were infected with shRNA lentivirus. Puromycin was added to eliminate non-transduced cells. Doxycycline (100 ng ml−1) was added to induce shRNA and GFP expression for 3 days. Efficiency of shRNAs was confirmed by western blot. Jurkat cells with CPT1a knockdown were treated with 200 μM C18:2 for 24 h. Mitochondrial ROS production and cell survival were measured in GFP+-transduced cells. Fatty acid oxidation was measured according to a previous publication37. 1-14C-C18:2 and 1-14C-C16:0 were purchased from PerkinElmer. Briefly, isolated CD4+ or CD8+ T lymphocytes were pretreated with C18:2 or kept in regular media. After 24 h, cell media was changed to media containing 50 μM cold C18:2 plus 1 μCi 1-14C-C18:2 per ml or 50 μM cold C16:0 plus 1 μCi 1-14C-C16:0 per ml. After 2 h, medium was removed and mixed with concentrated perchloric acid (final concentration 0.3 M) plus BSA (final concentration 2%) to precipitate the radiolabelled fatty acids. Samples were vortexed and centrifuged (10,000g for 10 min). Radioactivity was determined in the supernatant to measure water-soluble β-oxidation products. Mitochondrial membrane potential was measured by TMRM (ImmunoChemistry Technologies) staining according to the manufacturer's protocol. Briefly, cells were kept in culture medium with 100 nM of TMRM for 20 min in a CO incubator at 37 °C. After washing twice, cells were processed to flow cytometry analysis. Mitochondria-associated superoxide was detected by mitoSOX (Life Technologies) staining according to the manufacturer's protocol. Briefly, cells were first subjected to surface marker staining. Then cells were stained with 2.5 μM mitoSOX for 30 min in a CO incubator at 37 °C. After washing twice, cells were processed for flow cytometry analysis. OCR was measured using an XFe96 Extracellular Flux Analyzer (Seahorse Bioscience) as previously described38. AutoMACS-sorted mouse CD4+ and CD8+ T lymphocytes were attached to XFe96 cell culture plates using Cell-Tak (BD Bioscience) in RPMI media with 11 mM glucose. Cells were activated with 1:1 CD3:CD28 beads (Miltenyi BioTech) and vehicle or 50 μM C18:2 was added. Twenty-four hours after activation, cells were incubated in serum-free XF Base Media (Seahorse Bioscience) supplemented with 10 mM glucose, 2 mM pyruvate and 2 μM glutamine, pH 7.4, along with 50 μM C18:2 if previously present, for 30 min at 37 °C in a CO -free cell culture incubator before beginning the assay. Five consecutive measurements, each representing the mean of 8 wells, were obtained at baseline and after sequential addition of 1.25 μM oligomycin, 0.25 μM trifluorocarbonylcyanide phenylhydrazone (FCCP), and 1 μM each of rotenone and antimycin A (all drugs from Seahorse Bioscience). OCR values were normalized to cell number as measured by the CyQUANT Cell Proliferation Assay Kit (Life Technologies). Human liver samples were stained as previously described8. For immunostaining, formalin-fixed, paraffin-embedded human liver tissue samples were retrieved from the archives of the Institute of Surgical Pathology, University Hospital Zurich. Fibrosis grade was analysed for NASH according to NAFLD activity score (NAS)39 and for others according to METAVIR score40. The study was approved by the local ethics committee (Kantonale Ethikkommission Zürich, application number KEK-ZH-Nr. 2013-0382). Human PBMCs from healthy donors were obtained on an NIH-approved protocol and prepared as described previously41. Informed consent was obtained from all subjects. The sample sizes for animal studies were guided by a previous study in our laboratory in which the same MYC transgenic mouse stain was used. No animals were excluded. Neither randomization nor blinding were done during the in vivo study. However, mice from the same littermates were evenly distributed into control or treatment groups whenever possible. The sample size for the patient studies was guided by a recent publication also studying NASH-induced HCC, but focused on different aspects8. Statistical analysis was performed with GraphPad Prism 6 (GraphPad Software). Significance of the difference between groups was calculated by Student's unpaired t-test, one-way or two-way ANOVA (Tukey's and Bonferroni's multiple comparison test). Welch's corrections were used when variances between groups were unequal. P < 0.05 was considered as statistically significant.
Dettmer M.,University of Bern |
Dettmer M.,University of Pittsburgh |
Schmitt A.,University of Bern |
Steinert H.,University of Zurich |
And 3 more authors.
Histopathology | Year: 2012
Aims: Poorly differentiated thyroid carcinomas (PDTC) are an ongoing diagnostic challenge. Although the Turin consensus criteria for PDTC excluded consideration of oncocytic tumours, the World Health Organization (WHO) classification does recognise an oncocytic variant of conventional PDTC. The aims of this study were to establish whether the Turin criteria can be applied to oncocytic PDTC, and to determine if there are prognostic differences between conventional and oncocytic PDTC. Methods and results: We applied the Turin criteria to 129 thyroid carcinomas. We identified 18 oncocytic PDTC and 16 conventional PDTC. Kaplan-Meier analysis revealed a significantly worse outcome for oncocytic PDTC with regard to overall and tumour-specific survival but no difference for relapse-free survival, all of which were confirmed by multivariate analysis. There was no association of survival with gender, age or tumour stage. Conclusions: The Turin criteria can be applied to oncocytic PDTC and patients with this variant have a decreased survival using conventional radioiodine treatment compared to conventional PDTC and might therefore be candidates for novel treatment modalities. © 2012 Blackwell Publishing Ltd. Source
Diagnostic and prognostic implications of the PAX8-PPARγ translocation in thyroid carcinomas-a TMA-based study of 226 cases
Boos L.A.,TU Munich |
Boos L.A.,University of Zurich |
Dettmer M.,University of Bern |
Schmitt A.,University of Bern |
And 6 more authors.
Histopathology | Year: 2013
Aims: Follicular thyroid carcinoma (FTC) has been a diagnostic challenge for decades. The PAX8-PPARγ rearrangement has been detected in FTC and classic papillary thyroid carcinomas (PTCs). The aims of this study were to assess the presence of PAX8-PPARγ by using tissue microarrays in a large cohort of different thyroid neoplasms, and to assess its diagnostic and prognostic implications. Methods and results: Fluorescence in-situ hybridization (FISH) analysis for PAX8-PPARγ was performed on 226 thyroid tumours, comprising FTCs (n = 59), PTCs (n = 126), poorly differentiated thyroid carcinomas (PDs; n = 34), follicular thyroid adenomas (FTAs; n = 5), and follicular tumours of unknown malignant potential (FTUMPs; n = 2). PAX8-PPARγ was detected in 12% of FTCs, 1% of PTCs, 7% of PDs, and in both cases of FTUMP. There was no correlation between the extent of capsular or vascular invasion and PAX8-PPARγ, or between lymph node or haematogenous metastasis and PAX8-PPARγ. Overall survival (OS), tumour-specific survival (TSS) and relapse-free-survival (RFS) were not influenced by PAX8-PPARγ. Conclusions: In this study, we demonstrate for the first time the presence of PAX8-PPARγ in PDs and FTUMPs, whereas in FTCs and PTCs the prevalence of PAX8-PPARγ is lower than previously reported. PAX8-PPARγ did not correlate with invasiveness or affect prognosis in any tumour type. © 2013 John Wiley & Sons Ltd. Source


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http://sutherlandinstitute.org/wp-content/uploads/2015/03/logo_white_red_225x64.png 0 0 Sutherland Institute http://sutherlandinstitute.org/wp-content/uploads/2015/03/logo_white_red_225x64.png Sutherland Institute2004-12-01 14:49:082012-04-11 14:49:37Wages
By: Antonovics, Kate, and Robert Town.
These researchers use data from monozygotic twins and the Current Population Survey and find that marriage causes men's wages to rise. After controlling for educational attainment, first wage, and family size, they find that married men earn wages ranging from 19 to 26 percent higher than wages of unmarried men.
Are all the good men married? Uncovering the sources of the marital wage premium. American Economic Review 94 (May): 317-21.


text:
He was sitting on the couch that night
That night he was on the couch
His aunts and his uncles and sisters were gone
And he had nobody now
He softly looked out the window that night
That night he looked out the window
And when he looked he was all alone
And the rain was drizzling slow
He saw a shadow through the fog that night
That night he saw a shadow
An eerie figure of a tall woman
So to the shadow he would go
He put on his coat that night
That night he put on his coat
He put on his boots and gloves that night
He would no longer be alone
He opened up the door that night
That night he opened the door
He looked out right to the shadow
His feet on a creeky floor
He went into the cold that night
That night he was in the cold
So he wouldn"t be alone anymore
No more a lonesome soul
He walked towards that figure that night
That night he walked towards the figure
But the closer he walked, the farther it got
Yet he still walked through the winter
His boots sloshed through the mud that night
That night he sloshed through the mud
To find the figure of the woman
He would give up all his blood
It led him to the graveyard that night
That night he went to the graveyard
The graveyard where his family lay
Their bodies burned and charred
The figure disappeared that night
That night it disappeared
When he went to the graveyard
He shed a million tears
He lay by his family that night
That night, that's where he lay
And he passed away that night
A deathly figure in the rain
© Copyright 2017 hillaryanne. All rights reserved.
Status: Finished
Genre: Other
This was pretty creepy, I liked it. I really liked the first two lines of each stanza, how you said something, then switched it around a little and repeated it, that was really cool. The end was powerful, I never would have thought he would die! Great job on this :)
Poem / Poetry
Poem / Poetry
Poem / Poetry
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Force Supports Lesbian, Gay, Bisexual and Trans History Month
Monday 1 February, 2016
West Yorkshire Police and the Police and Crime Commissioner for West Yorkshire are supporting Lesbian, Gay, Bisexual and Trans History Month as part of our continued hate crime campaign.
To coincide with February's LGB&T History Month, a particular focus is being placed on raising awareness of homophobic and transphobic hate crime and how to report it. Over the coming month, officers will be engaging with lesbian, gay, bisexual and transgender communities at LGB&T History Month events.
LGB&T History Month aims to promote equality and diversity and celebrate the lives and achievements of both lesbian, gay and bisexual and trans communities.
The joint 'Hate Hurts' hate crime campaign was launched in 2014 to raise awareness of the five strands of hate crime - race, sexual orientation, faith, disability and gender identity.
Temporary Assistant Chief Constable Angela Williams said: "This coming month is all about celebrating the achievements of lesbian, gay, bisexual and trans communities.
"As a society we have come a long way in our understanding and acceptance of all sexual orientations and gender identities. Unfortunately though there remains a small minority who think it is acceptable to target someone because of their sexuality or gender identity.
"At the heart of our hate crime campaign is the message that being who you are is not a crime and is something that you should be proud of but targeting a particular individual because of their perceived differences is abhorrent and something that will not be tolerated.
"We would urge anyone who has been a victim of, or witnessed, a hate crime or incident to report it to us. That way we can ensure that it is dealt with, with support put in place and appropriate action taken against those responsible."
West Yorkshire's Police and Crime Commissioner (PCC) Mark Burns-Williamson said: "Hate crime is committed against people when they are targeted because of their race, sexual orientation, religion, disability or gender identity...essentially for being who they are which is never acceptable.
"With West Yorkshire Police, I am committed to tackling all hate crime, putting victims and witnesses at the heart of what we do, we all have a responsibility to challenge the attitudes and behaviours that foster hatred.
"As your PCC I am ensuring the right services are put in place and commissioned for victims and witnesses of hate crime having just given out more than £110,000 through a targeted grant round to organisations with plans to tackle hate crime head on. The fact that this money, from my ring-fenced Victim Support Services Fund, was oversubscribed with applicants applying for more than £500,000 shows how important it is that we all work together to ensure that victims of hate crime feel supported and reports acted upon appropriately."
Anyone with information about a hate incident is asked to report it either by calling 999 in an emergency or 101 in a non-emergency, online at www.westyorkshire.police.uk/hatecrime or www.report-it.org.uk or in person at a police station.
Alternatively, there are independent Hate Incident Reporting Centres (HIRCs) across West Yorkshire for anyone who does not want to speak directly to the police. To find your nearest centre visit the West Yorkshire Police website.
For non-emergencies dial 101
In an emergency always dial 999


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"Dance Moms" took a dramatic turn in Season 4 when studio owner Abby Lee Miller brought in a second competition team to her studio. She tells Zap2it how it all came about and that the new team of girls will continue to be featured in Season 4.
"What I was suggesting [to the network] was that we go around the country and do four mega-conventions, workshops, masterclasses that I do anyway on my own," says Miller. "I wanted to cut all of that in and do it bigger, on a grander scale, to find the next cast of 'Abby's Ultimate Dance Competition.' … But when ['Abby's Ultimate Dance Competition'] got put on hold for me to do this new show, 'Abby's Studio Rescue,' we decided that because all the plans were made, we needed to use the kids for a new team, so that's how that happened."
When Season 4b begins shooting, "both teams are going to be here some of the weeks," Miller continues. "Some of the weeks it will be me going up against Cathy. Some weeks it will be the original team and I might bring in a kid from the new team to dance with them."
The one thing we won't be seeing later this year is the return of "Abby's Ultimate Dance Competition." Miller explains that due to the competition nature, it isn't as success overseas as "Dance Moms," so it is on hold for now. Miller will launch "Abby's Studio Rescue" on Tuesday, June 17 on Lifetime.
Meanwhile, Miller continues to expand her repertoire, donning the hat of music producer for Mackenzie Ziegler's debut video and album.
"All of the music on Mackenzie's album is very empowering," says Miller, "and I even do a guest spot on one of the songs. It was so interesting to do that and learn about the recording industry. Every day on this job I learn something new."
Information about Ziegler's album, "Mack Z," can be found here. It debuted at No. 1 on the iTunes pop charts. "Dance Moms" Season 4b returns later this year.


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More Videos...
It's Got Frickin LASER Beams! 10 Second Plymouth Laser Turbo - Kyle Cimbron 10.36 @ 134mph
1g awd DSM Drag Race Kyle Cimbron running a new best 10.367 @ 134.14 MPH on DOT Street Legal Hoosiers in his mint condition 1g Plymouth Laser RS. Won the Forced Induction Sport Class at Import Face Off at New England Dragway. Car info:turbo is a FP3565 (old school Non HTA 35R in FP's bolt on housing) Quartermaster Twin Disc, FIC 950's, C16 fuel. www.uRaceIfilm.com - Drag Race Videos www.Facebook.com/Professional Spectator Drag Race Videos, Import Drag racing, Muscle car drag racing, street racing, how to's, parts reviews, turbo, all motor, Nitrous, supercharged. New England DSM New England Dragway Epping, NH 10/13/13
10 Second Plymouth Laser Turbo on Hoosiers! Kyle Cimbron 10.60 @ 132mph
1g awd DSM Drag Race Kyle Cimbron running a new best 10.60 @ 132mph on DOT Street Legal Hoosiers in his mint condition 1g Plymouth Laser RS. After running some high 10's on pump gas he dumped in a few gallons of C16 and made some more power. Took 2nd place in the Pro Shootout class at New England Dragway's Import Wars. Car info:turbo is a FP3565 (old school Non HTA 35R in FP's bolt on housing) Quartermaster Twin Disc, FIC 950's. 37psi Boost, 1/4 tank pump gas with 2 gallons of C16. www.uRaceIfilm.com - Drag Race Videos New England DSM New England Dragway Epping, NH 9/8/13
1941 Plymouth Special Deluxe Business Coupe - Jay Leno's Garage
1941 Plymouth Special Deluxe Business Coupe. Jay goes old school with this bulletproof pre-Pearl Harbor Plymouth, passed to him by a man known as Fred the Kingpin. There's really nothing like original and unrestored, before power steering and brakes, when America built the best cars in the world... » Subscribe: http://bit.ly/JLGSubscribe » Visit the Official Site: http://bit.ly/JLGOfficialSite THE BEST OF JAY LENO'S GARAGE » Exclusive First Looks: http://bit.ly/JLGExclusives » Ultra Rare Supercars: http://bit.ly/JLGSupercars » Jay's Book Club: http://bit.ly/JLGBookClub JAY LENO'S GARAGE ON SOCIAL Follow Jay: http://Twitter.com/LenosGarage Like Jay: http://Facebook.com/JayLenosGarage ABOUT JAY LENO'S GARAGE A new video every Sunday! Visit Jay Leno's Garage, the Emmy-winning series where Jay Leno gives car reviews, motorcycle reviews, compares cars, and shares his passion and expertise on anything that rolls, explodes, and makes noise. Classic cars, restomods, super cars like the McLaren P1, sports cars like Porsche 918 Spyder and Camaro Z28, cafe racers, vintage cars, and much, much more. Subscribe for more: http://full.sc/JD4OF8 NBC ON SOCIAL: NBC YouTube: http://full.sc/MtLxIM NBC Facebook: http://facebook.com/NBC NBC Twitter: http://twitter.com/NBC NBC Google+: https://plus.google.com/+NBC/posts 1941 Plymouth Special Deluxe Business Coupe - Jay Leno's Garage http://youtu.be/gd5qq9e3apk Jay Leno's Garage http://www.youtube.com/user/jaylenosgarage
Eagle Talon Acceleration 22psi 20g TSi AWD
Just a brief pull I did from 35-115mph in my old 92 tsi awd. Fully stock motor. Stock block stock head. Stock trans. stock manifold and maf. just tuned on 91 pump gas when i didnt know hardly anything about what i was doing. car ran 12.7@107 on this setup I was bored and just made the vid for shits and giggles. Yes I know its really shaky. Sorry my camera mount wasnt with me and shifting/driving/recording = a pita.


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Stuffed Mushrooms with Feta Cheese and Spinach - Part 2 - Stuffing Mushroom and Grilling
|Extra virgin olive oil
|2 Tablespoon
|Softened butter
|4 Tablespoon
|5 Small, minced
|2 Clove (10 gm), minced
|1 Cup (16 tbs), finely shredded
|Sea salt
|1 Dash
|Black pepper
|1 Teaspoon ((or to taste))
|Meyer lemon juice
|1 Tablespoon
|Organic chicken broth/Vegetable broth
|1 Cup (16 tbs)
|Italian seasoned bread crumbs
|8 Ounce
|Organic salt free white wine
|1 Cup (16 tbs)
|Parmesan cheese
|1 Cup (16 tbs), shredded
|Feta cheese
|1 Cup (16 tbs), crumbled
|10 Large, stem removed
1. In a large pan, heat olive oil and butter over medium high heat.
2. Add the minced shallot and garlic to the pan; let soften under medium high heat.
3. Add the finely shredded spinach to the pan and season with salt and pepper.
4. Add Meyer lemon juice and ¼ cup Organic chicken broth.
5. Add the bread crumbs and more ¼ cup Organic chicken broth.
6. Add half of the Organic salt free white wine and give it a quick stir.
7. Remove pan from heat and add parmesan cheese and feta cheese; mix well.
8. Use the spinach cheese mixture for stuffing the mushroom caps.
9. In a baking dish, place the stuffed mushrooms and sprinkle little bit of parmesan cheese on top of each mushroom.
10. Pour the remaining white wine in between the gaps of mushrooms; do not pour on top as it will wash away the cheese.
11. Grill in oven for about 10 minutes.
12. Serve the stuffed mushrooms with a salad on the side.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 688 Calories from Fat 336
% Daily Value*
Total Fat 37 g57.5%
Saturated Fat 18 g90%
Trans Fat 0 g
Cholesterol 82.6 mg27.5%
Sodium 2449.5 mg102.1%
Total Carbohydrates 58 g19.3%
Dietary Fiber 3.3 g13.2%
Sugars 6.8 g
Protein 24 g47.7%
Vitamin A 35.1% Vitamin C 16.4%
Calcium 64.8% Iron 20.9%
*Based on a 2000 Calorie diet


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Experienced mature Mistress is something every slave dreams about in his sleazy fantasies. Look how nasty this bitch is in her super-sexy black leather outfit, posing with her toys and spreading her pussy lips so that your cock is ready to explode!
Super-hot strapon action in total darkness! Semi-naked Mistress in sexy fishnet stockings teases her muscular slave with her nakedness and then drives her red strapon righr up his ass! He loved that and licked her gorgeous tits in gratitude.
Two sexy Mistresses in pretty lingerie train a dog. Such training is not an easy thing, you have to win complete control over your dog. Some trampling and spanking will surely help!
Witness a busty Mistress in sexy black leather outfit dominate an obedient slave. She makes him worship her feet, gags him and puts a mask over his eyes. Then she rubs her huge breasts against him, which brings him ultimate subdued pleasure.
And then she was raping me with her strapon. She was fucking me for such a long time and so quickly that I almost cummed. But I have no rights to do it. My mistress ordered me not to let the cum out of my body without her permission. If there are only other slaved right by me at that time, that's when I can come.
I'll make a suspended upside down mummy out of this slave. And then I get his scrotum naked and will play a little with it. Some needles will make him beg me stop it. He's so tender.
While the girl was imprisoned in her cage, I decided to suspend the male slave and play with him for a while. What a pleasure it was to slap him and attack his reddened butt with my strapon. I flew into a real dominatrix passion and trampled his balls for a while and made him suck my fingers. How amazingly beautiful it was!
Sometimes dressing a slave as a sexy girl does not fully satisfy me. I want to make full use of his subdued femininity, and look how I do it. Poor thing, he was tied to the bed and I made him suck my long strapon. Also I couldn't but fuck his tight ass and give him a bit of pleasure of fondling his erect cock.
Some slaves do enjoy when I play with their tight asses and stuck something there. So there is this victim, gagged and tied doggy style. What else could I do but fetch my favorite balls and started penetration games with his asshole?
I'm the happiest slave in the world today. My mistress gave me her saliva. She barely touched my lips when she was spitting into my mouth.


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Frank Rijkaard will take over as Galatasaray coach replacing Bulent Korkmaz as technical director, the Turkish club said today.
The club's web site which gave the news did not provide further details but broadcaster CNN Turk said Rijkaard would arrive in Istanbul at 1430 GMT.
Former Galatasaray captain Korkmaz had been appointed coach in February in place of Michael Skibbe, who was sacked after a poor run of results. Korkmaz had a contract until the end of the 2009-2010 season.
Galatasaray, Uefa Cup champions in 2000 and 17 times domestic champions, had a disappointing season and finished fifth in the league, ten points adrift of champions Besiktas.
Rijkaard had previously been mentioned as a possible candidate to take over at various clubs including AC Milan and CSKA Moscow.
The former Dutch great took charge of Barcelona in 2003 and led them to back-to-back league titles and victory in the Champions League in 2006. He left the club in May last year.
- More about:
- CSKA Moscow
- Galatasaray SK
- Süper Lig
- Turkish Football


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Nick Bonino: Second Line Center?
J.D. Burke
July 07 2014 10:22AM
The first step of the "retooling" job that Jim Benning inherited with this roster involved trading away locker-room malcontent Ryan Kesler. The move was bound to clear up cap space necessary to not only keep their own RFAs like Chris Tanev and Zack Kassian around, but also dip into the free agent pool.
The fact that Kesler had essentially given the Canucks a list of one and a half teams he'd waive his no-trade clause for allowed Canucks fans and media to preemptively temper their expectations on the prospective return. Then the inevitable happened.
Ryan Kesler was traded to the Anaheim Ducks in exchange for Nick Bonino, Luca Sbisa and the 24th overall pick in this year's draft. You figure that the Bonino component of the package would be the centerpiece in the eyes of the Canucks, given that he's currently viewed as the favourite to fill the spot the guy he was traded for successfully occupied for years prior.
Is Nick Bonino really a capable 2nd line center option, though?
Does Ryan Miller make the Canucks a better hockey team?
Cam Charron
July 05 2014 09:00PM
I've started a new job, and people have gradually begun to learn what I did with my old one, which is analyze and write about hockey. A few co-workers have asked why it is I'm not as keen on the Ryan Miller signing as others, and I think that the answer goes well beyond "don't overpay for goalies, because they're random".
The right answer here is that even if Miller were to provide a significant upgrade over Eddie Lack in net, is it really something the Canucks need?
Canucks sign Chris Tanev to one-year deal, put off long-term commitment for now
Dimitri Filipovic
July 05 2014 01:11PM
It was just yesterday that Dan Murphy joined me for a podcast in which we discussed the very real likelihood of a deal between restricted free agent Chris Tanev and the Canucks dragging out this summer.
It sure didn't take long for that conversation to become dated; with a potentially unfavourable arbitration process for the player looming, the two came to terms on a 1-year deal that could wind up being beneficial for both parties in the long run. But particularly the Canucks, as Jim Benning's largely inspiring first summer as the team's GM continues on.
Canucks Army Podcast: with Dan Murphy
Dimitri Filipovic
July 04 2014 01:46PM
Friend of the blog, Sportsnet's Dan Murphy, was kind enough to hop by for a chat with me about the current state of affairs for the Vancouver Canucks. In the podcast below we touched on a variety of topics including:
- How much say Jim Benning had on this past draft class
- Why the Canucks felt the need to give Ryan Miller the contract that they did
- How many of the circulating stories about John Tortorella were actually true
- Where the team and Chris Tanev currently are in their negotiations
- How progressive the new braintrust will be in using analytics to help make decisions
Two RFA deals down, two to go; Zack Kassian signs on for 2 years, Yannick Weber for 1
Dimitri Filipovic
July 04 2014 10:49AM
The Canucks made two very notable signings this past week, leaving them with roughly $7 million left in cap space to lock up their four restricted free agents. They got one of those done on Thursday evening when they agreed to a 2-year deal with Zack Kassian.
Kassian's time in Vancouver has been a rather bumpy one thus far - having been traded for a polarizing young player like Cody Hodgson, then being asked to live up to expectations ranging anywhere from Milan Lucic to Todd Bertuzzi - but despite all of that, he's trending in the right direction. He may never wind up reaching the lofty goals some people have built up for him, but that doesn't mean he can't continue to grow into a fine player over these next two seasons.


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I was looking for textures when I found these nice linen textiles, so I started to "sew" them together...
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R-T Photo/Diane LowreyDino's Diner celebrated its one-year anniversary with a ribbon cutting on Wednesday. The ribbon cutting was sponsored by the Trenton Area Chamber of Commerce and Trenton Ambassadors.
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STARmeterSEE RANK
Down 57,000 this week
Francis Greenslade
Francis Greenslade was born on October 3, 1962 in Honiara, Solomon Islands. He is an actor and writer, known for Shaun Micallef's Mad as Hell (2012), Winners & Losers (2011) and The Micallef Program (1998). He has been married to Louise Greenslade since September 4, 1999. They have four children. See full bio »
Born:in Honiara, Solomon Islands


text:
M G Road, Indore
B.E., B.Tech, MCA, BCA and MSC IT students.
Interest in learning PHP
Writing Pad
§ Good opportunity to work on live project-domestic and offshore.
§ All the candidates will awarded with the Training Certificate.
§ Trainees can choose interested field.
§ Good company environment.
§ Guidance for placement and training for interview.
Not decided yet
Students Interested 0


text:
Event: Bollywood actors Ayushmann Khurrana, Kunaal Roy Kapur, Pooja Salvi, Gaelyn Mendonca, Evelyn Sharma, T-series head honcho Bhushan Kumar along with wife Divya Kumar, singer Tulsi Kumar, director Rohan Sippy, filmmaker Ramesh Sippy with wife Kiran Juneja were snapped at the success bash of the film NAUTANKI SAALA!
Guest List: Ayushmann Khurrana, Kunaal Roy Kapur, Pooja Salvi, Gaelyn Mendonca, Evelyn Sharma, Bhushan Kumar, Divya Kumar, Rohan Sippy, Ramesh Sippy, Kiran Juneja, Tulsi Kumar
Bollywood actors Varun Dhawan and Alia Bhatt promoted BADRINATH KI DULHANIA. Varun and Alia Bhatt displayed their chemistry.
Bollywood actress Urvashi Rautela celebrated her birthday with family.
Bollywood celebs like Shatrughan Sinha, Armaan Malik, Subhash Ghai, Alia Bhatt, Sonu Sood, Raveena Tandon, Sunny Deol, Vivek Oberoi, Sophie Choudry, Jeetendra, Jacqueline Fernandez, Shreyas Talpade, N...
Suuny Deol spotted at Bandra and look all ready for summer
Barbie doll Katrina Kaif and Rohit Roy spotted at the aiprort looking causal and smart.