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Hotels in Bransford
Hotel reservation
United Kingdom
Hotel rooms in Bransford
There are not so many hotel rooms in Bransford, just 2, still everyone can find an offer to suit his choice. The most common offers in this city are 3 и 4 stars, they count 1 out of 2, and their prevalent location is central district. According to our practice, it is the most profitable to book a hotel in the south of Bransford, as it is the location of the hotels with optimal cost and quality offers along with the cheap hotels. Taking into account the small size of the city, there is no need to dwell hotel reservation on the location: the road to the city center would take less then half an hour, so one can book a hotel in any district of Bransford. The most populated with hotels district of Bransford is the south, 50% of cheap hotel rooms are concentrated here. Bransford is an ideal place for couple and solo, such travellers rate hotels there 8.6 out of 10 on average. Apart from all these, hotels in Bransford offer their customers laundry service, pets allowed, spa and gym. The most appreciated amenities in Bransford hotels are pool and amenities. According to the visitors reviews, hotels in Bransford has great location, rather comfortable and fantastic service. Take a look at our selection of the cheap hotel rooms in Bransford to make a well-informed choice for your reservation!
Best hotels in Bransford
Hotels in Bransford are spread around the city within the distance of 2.5 kilometers, while 1 hotels are located directly in the city center. The most popular accommodations in Bransford is
Bank House Hotel, Spa & Golf Club
, 3 stars hotel located in a 0.2 kilometers from the city center.
The best hotels are here and now. Try them!
All cities in United Kingdom


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National Action Plans
OGP participating countries will co-create a National Action Plan (NAP) with civil society. Action plans should cover a two-year period and consist of a set of commitments that advance transparency, accountability, participation and/or technological innovation.
On this page are guides to developing OGP action plans. You can refer to the National Action Plans Guidance Note that's available in the PoC Manual (español).
OGP participating countries operate on a two-year NAP calendar cycle, in which there are no gaps between the end of the last action plan and the beginning of the new one.
This means every country will be implementing a NAP at all times, although individual commitments still vary in length. In order to achieve this, countries will draft their new NAPs during the last six months of implementation of the previous NAP. All NAPs should cover a period of implementation of a minimum of 18 months, although individual commitments may vary in length. We strongly recommend that each action plan contain between 5 and 15 ambitious commitments
Countries, with the active involvement of civil society, are encouraged to tackle new and ambitious commitments as well as build upon past successes. Effective public consultation process during the development of action plans can help build broad support for commitments with a wider set of actors to rely on for successful implementation.
Guidance on conducting public consultation can be found here.

subset: commoncrawl


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Cadillac introduced the new coupé version of its mid-range CTS to European customers at the Geneva Motor Show this week. The new car shares its wheelbase with the standard four-door saloon but has a lower roof-line and is slightly shorter overall; most of the bodywork is unique to the model. The coupé's standard engine is the 3.6-litre V6, which is the larger of the two options available on the saloon.
The company also showed the CTS estate at Geneva, as well as a 2011 version of the high-performance CTS-V. Although the likeable CTS is much more competitive with mainstream and even premium European models than past American cars, it has so far sold only in small numbers on this side of the Atlantic. The expansion of the range to include coupés and estates may prompt European buyers to take a second look, although there's still no sign of the diesel option that has sometimes been mentioned as a likely future development.
The CTS – usually considered a rival for cars such as the BMW 5-Series and Mercedes E-Class - is Cadillac's smallest model now that the Saab-based BLS is no longer on sale.Reuse content


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At a glance
- Originator Eli Lilly
- Class Antivirals; Small molecules
- Mechanism of Action Undefined mechanism
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
On Fast track
Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.
Highest Development Phases
- No development reported Influenza virus infections
Most Recent Events
- 20 Oct 1999 New profile
- 20 Oct 1999 Preclinical development for Influenza virus infections in USA (Unknown route)


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US: +1 630 333 9501 UK: +44 208 123 1770 firstname.lastname@example.com
Virtual Schools Market in the US 2015-2019
Outlook of the virtual school market in the US
The setup of virtual schools works best for parents with busy schedules and a career with high mobility. Hence virtual schools are more popular with children of expatriates, or families that are unable to enroll their children in traditional schools due to lifestyle, geographic, and time zone concerns. Technavio's market research analysts project the virtual schools market in the US to grow at a CAGR of around 29% until 2019.
Virtual schools with flexible timings are also best suited for students pursuing core training in sports with a need to practice for 6-7 hours a day. Availability of vast course options such as language learning, technical education, music, and theatre in addition to the mandatory curriculum has also led to the rising popularity of virtual schools in the US.
Research scope and segmentation of the virtual school market in the US
To calculate market size, analysts have considered revenues generated from the enrolments at virtual schools across three categories:
- Primary schools
- High schools
- K-12 schools
Virtual schools market segmentation in the US by enrollment 2019:
Key market drivers, trends, and challenges
The convenience and ease of availing education programs without investing in hands on practical applications and classrooms drives the demand for virtual schools. The required expenditure of a virtual school is 50-60% less than the overall expense incurred in a traditional school environment.
User-friendly web conferencing solutions are fast emerging as a key trend in this market. The complexity of a web conferencing product tends to increase with the rise in integrated features. Hence, major vendors in this market are developing improved user interfaces that are capable of delivering effective lectures without any technical or operational glitches.
Top companies in the virtual school market in the US analyzed in this report
- Connections Academy
- Mosaica Education
- White Hat management
Other prominent vendors
- Articulate
- Blackboard
- Edison Learning
- Echo360
- Glance Networks
- Haiku Learning
- Instant Presenter
- InterCall
- Jenzabar
- Onstream Media
- R-HUB Communications
- Radvision
- Saba Software
- Schoology
Key questions answered in the report
- What are the key factors driving the virtual school market in the US?
- What are the key market trends impacting the growth of the virtual school market in the US?
- What are the various opportunities and threats faced by the vendors in the virtual school market in the US?
- Key outcome of the five forces analysis on the virtual school market in the US?
- Growth forecast of the virtual school market in the US?
Technavio also offers customization on reports based on specific client requirement.


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A series on navigating pregnancy in Baltimore.
The weekly fête is back for its 38th run.
Ten events to spring into your pre-summer happy place.
We scoured area markets and shops to fill our carts with some of the best items around town.
Baltimore's public market system is the oldest, still operating public market network in the U.S.
The summer-long market on Alleghany Avenue celebrates its 36th run this year.


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We have 3 of Corkscrew Vallisneria Medium Plastic Aquarium Plant currently in stock. If you would like us to e-mail you when more are available, please fill in the form below. You will receive a confirmation e-mail, and if we have any questions we will follow up with another e-mail shortly, otherwise you can expect to hear from us when Corkscrew Vallisneria Medium Plastic Aquarium Plant is available in the quantity you are looking for. Thank you
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Honest Kitchen Keen Dehydrated RAW Dog Food 10 lb
$ 66.55
Sign Guard Pekingnese On Duty 8 x 4.75 inch Laminated
$ 2.39
NutriSource Dog Lamb and Rice Dog Food 12-1 3oz. cans
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Laxatone Cat Hairball Lubricant 4.25 ounce
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AquaClear 20 Activated Carbon Aquarium Filter Insert
$ 1.88
Stainless Steel Dog Food/Water Bowl 2 Qt 2 pack
$ 6.62
Galapagos Natural Moss and Wicker Birdhouse Shack
$ 9.74
Taste of The Wild Pine Forest Canine Formula Dog Food 14-Lb.
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First of all, let me confess that, despite my affinity for electric guitars, I've never been much of a rock 'n' roller. Truth to tell, I'm more likely to pick up an acoustic guitar or banjo. But I love the "art" of electrics, and they are fun to play, I admit, especially pushed through my old Rat distortion box. But sometimes that "art" goes somewhat awry. At least, in my aesthetic opinion, that's what happened with the '83 Hondo H-2 featured here!
Workin' for the Weekend. No really! (The Story of Hondo Guitars)
Hondo was founded by Freed and Tommy Moore in 1969 with the intention to open up guitar production in Korea, at that time a non-player in the guitar game. Japan had taken over from Europe as the primary supplier of budget-level guitars during the 1960s. However, even by the late '60s the success of the Japanese was being eroded by their very success and the strength of the yen. Americans, mostly as an after-effect of World War II, had little respect for Japanese products and weren't willing to pay much for them, even if they were pretty good. When Nixon cut the dollar loose to float with other currencies on the free market, the yen went up, making Japanese products increasingly expensive, a problem in a prejudiced, price-sensitive market like the US.
Roundup for a Texas Longhorn (1978 Hondo II Longhorn Electric Guitar)
Most of us probably know this longhorned guitar shape from the legendary Danelectro Guitarlin. Indeed, this Hondo guitar was intended to be a tribute to that '60s beauty. Danelectro bit the dust in 1969, yielding to the beginnings of international guitarmaking.


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- CrackBerry Genius of Geniuses
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Aldiko Book Reader
Been looking for a good eBook Reader, and have not been very successful with the options available in BBWorld. Book Reader the app I used on my PlayBook and on my Z10 in the beginning, seems to be having issues and is no longer supported by the developer. The Kindle App is pretty good but requires you to convert epubs.
Tried a few highly rated apps in Google Play, and the Aldiko Book Reader seems to work very well. BB10 does register it as a default program for opening epub files, so all you have to do is click on the file and Aldiko Book Reader opens and adds the files to it's library.
Just wondering if anyone has bought the full version of this app? I think it might be worth it for the extra features, if the paid version will load.
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The LifeLine Essential Hacksaw is the perfect tool for cutting steerer tubes and trimming handlebars town to size. The rubber grip handle allows you to get a firm but comfortable grip.
Thank you for visiting LifeLine Essential Hacksaw Workshop Tools on oakleysbikes.co.uk
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Syrian Opposition Leader Who First Suggested Negotiations Is Now Wary On Geneva Talks
Moaz al-Khatib was the first Syrian opposition leader to propose negotiations with the Assad regime. Now he's watching from the outside.
ISTANBUL — Moaz al-Khatib was the first Syrian opposition leader to suggest negotiations with Bashar al-Assad's regime. He proposed them a year ago while president of the Syrian National Coalition, which is in Geneva now for the first round of peace talks between the two sides. The idea, still controversial among the opposition, was even more divisive then — and Khatib saw backlash from within its ranks. He dismissed these critics as armchair generals, as he wrote at the time: "sitting down on their couches and then saying, 'Attack — don't negotiate.'"
A prominent Damascus imam, Khatib had been arrested multiple times for his activism against Assad. Amid the fractious politics of the opposition-in-exile, many Syrians saw him as a uniquely charismatic and effective leader, a view shared by many in the West. But the coalition's toxic mix of internal factionalism and outside meddling pushed him to resign last April, and he has largely kept out of the spotlight since.
In a phone interview with BuzzFeed, Khatib said he'd been paying close attention to the talks in Geneva, where the first round will likely draw to a close on Friday with little progress. And while he still supported the principle of negotiations, he said, he was wary of the current process — concerned that it might be intended mainly "to buy time and give some countries that are feeling guilty the chance to say, 'we gave it our best.'"
"Let us wait to see what will happen," he said. "If this is the beginning of a resolution [to the conflict], which I understand will take some time, then it will be a good thing. But if it's a kind of game, I would say to all the countries involved that they will pay a price for this game."
The U.S. and Russia have sponsored the Geneva conference, with each pushing its respective ally to attend and advising it as the talks play out. But Khatib said he expected more from the U.S. — which pushed hard for the coalition's formation in late 2012, in a process that ended with him holding the reins.
"The U.S. can do better," he said, adding that it should put greater pressure on both Russia and Iran to stop supporting Assad and push him to end the war. "I don't care about the negotiations between the Russians and the Americans if it will not help the Syrian people end their slaughter," he said.
Khatib also expressed frustration with the U.S. decision not to punish Assad for using chemical weapons on civilians outside Damascus this summer, despite President Barack Obama's famous warning that such an attack would be a "red line" for him. "Mr. Obama talked about red lines many times. Why put this in the picture if you can't support it?" he said. "Don't promise something you can't do."
Khatib also criticized the opposition's international allies for encouraging the war against Assad while doing too little to support it. "They were thinking they can destroy the regime militarily […] without helping us with enough tools at the time," he said. "Many of them lied, and many of them broke their promises."
He added: "The international community believed that it would be easy to stop the regime, or to change it. I believed that it had deeper roots, and deep support from the Russians, the Iranians and many other countries."
If Khatib were still leading the opposition, he said, he wouldn't have attended the Geneva conference. He would have insisted on some humanitarian relief first. "They must push to stop the aircraft attacks and release, at a minimum, the women and children being held prisoner. It is a shame for the world's governments to allow that," he said. "Without that I would not go."
Still, he added, "it is good that Geneva happened. But Geneva is not a target. It's just a way to arrive at the target. We will wait to see the results."
- The Trump administration wants to send immigrants caught at the southern US border to Mexico even if they're not from the country.
- Several states will keep enforcing bans against transgender discrimination in schools after Trump withdrew guidelines protecting students.
- Police arrested at least 10 people on Wednesday as they began clearing out protester camps at the Dakota Access Pipeline site.
- And people with disabilities are having their photos stolen and Facebook isn't helping them.


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Sarah Hyland attended the premiere of Disney's 'Cinderella' held at the El Capitan Theatre on Sunday (March 1) in Hollywood, California.
The 'Modern Family' actress wore a beautiful charcoal frock from Naeem Khan's Pre-Fall 2015 collection, which was a playful and fun way to celebrate this movie.
What I love about this dress is its classic shape, which brims with elegance, while the adornments bring a touch of glamour further amped up with the metallic-silver Brian Atwood 'Tamara' sandals.
Credit: Getty


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Hanging out streetphotography sea sunset sky landscape Taking Photos enjoying life clouds and sky Istanbul eye4photography hot_shotz — in İstanbul, TURKEY
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Freshen up your casual wardrobe with this bold, printed logo tee from Carhartt. Its made from 100% cotton with a crew neckline and the brand label at the hem. Wear this striking top on off-duty days with jeans and trainers.
Thank you for visiting Carhartt Shifted Printed Crew Neck T-Shirt, Dark Petrol/Severn on shoppingfind.co.uk
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The Xterra always seems to draw road-trip duty. Whether it's to act as camera car for a photo shoot, haul test gear to the track, or carry the spares and rations on a multicar comparo, our not-so-mellow-yellow Xterra is up to the task. The Xterra's 15K-mile service came and went without fanfare: $82 covered an oil and oil-filter change, a new air filter, and an overall inspection. We'd previously noticed the rear lift gate wasn't happy staying in the up position; a new pair of rear gate stays solved the problem, and that job was covered under warranty. Otherwise, "she works like a dog," issuing no complaints in the process. All interior materials are wearing well, though outside, the plastic fascias and bumpers like to be kept clean and treated or they start looking shabby. If we owned this Xterra, we'd be itching for the standard 15-in. tires to wear out so we could replace them with a better-performing +1 wheel/tire combo. And who wouldn't like more power? But that's coming for '02. Otherwise, we're still happy with choosing the Xterra as our 2000 Sport/Utility of the Year. And apparently, so are you, as sales are extremely brisk.
Base price: $25,799
Price as tested: $26,398
Vehicle layout: Front engine, 4WD, 4-door, 5-pass
Engine: 3.3L V-6, SOHC, 2 valves/cyl
Hp @ rpm: 170 @ 4800
Torque @ rpm: 200 @ 2800
Transmission: 4-speed automatic
0-60 mph, sec: 10.9
EPA mpg: 15 city/19 highway
Total mileage: 16,197
Avg test mpg: 15.7
Problem areas: Faulty rear deck stays
Non-warr cost: $82


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Surgery for ovarian cancer
This page is about surgery for ovarian cancer. You can find the following information
Surgery for ovarian cancer
Surgery for ovarian cancer is usually quite a big operation. The type of surgery you have depends on the stage of your cancer. But you are most likely to have your ovaries, fallopian tubes and womb removed. This is called a total abdominal hysterectomy (TAH) and bilateral salpingo oophorectomy (BSO). The surgeon will also remove a sheet of tissue from inside the abdomen. This tissue is called the omentum, so this part of the operation is called an omentectomy.
If the cancer has spread to other areas of your pelvis or abdomen, your surgeon will remove as much of the cancer as possible. This is called debulking. The less cancer there is after surgery, the easier it is for chemotherapy to kill off any that is left behind.
Interval debulking surgery
You may have some chemotherapy before debulking surgery. The aim is to shrink the cancer so that it is easier to remove it. You have the rest of your chemotherapy once you have recovered from the operation.
After your operation
You usually go home about 3 to 4 days after your operation. Your doctors will contact you when they have the results of your surgery. They may give you these over the phone, or you may come in to the hospital. If you would rather have your results face to face, tell your nurses and doctors before you go home after your operation.
You can view and print the quick guides for all the pages in the treating ovarian cancer section.
Surgery for ovarian cancer is usually quite a big operation. The surgeon (gynaecological oncologist) needs to make sure that they remove as much cancer as possible. You will be in hospital for 3 to 4 days. And recovering at home afterwards for at least another month or so.
Most women with ovarian cancer will have surgery to remove
- Both ovaries and fallopian tubes
- The womb, including the cervix
This operation is called a total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO).
If you have a borderline ovarian tumour or a low grade very early stage cancer (stage 1a) you may have just the affected ovary and fallopian tube removed.
Surgery for early ovarian cancer
During surgery to remove your ovaries and womb, the surgeon will take samples from several areas within the abdomen and pelvis to find out if the cancer has spread. This is so that they can fully stage the cancer. This helps the doctor decide if you need treatment after surgery.
Your surgeon will remove a layer of fatty tissue that is close to the ovaries, called the omentum. This is important as ovarian cancer can spread there. Removing the omentum is called an omentectomy.
Your surgeon will put some sterile fluid inside your abdomen and then remove it. They then send this to the laboratory to see if it contains cancer cells. This is called peritoneal or abdominal washings.
Your surgeon may remove some lymph nodes from around the womb and ovaries, in the pelvis and from your abdomen. They will also take samples of tissue (biopsies) from the lining of your pelvis and abdomen to check for cancer.
Surgery for advanced ovarian cancer
If the cancer has spread to other areas in your pelvis or abdomen, your surgeon will aim to remove as much of the cancer as possible. This is called debulking. The less cancer there is after surgery, the easier it is for chemotherapy to kill off any cells left behind. As above, your surgeon may take several samples from within the abdomen and pelvis to check where else the cancer may have spread to. If you have fluid in your abdomen (ascites), they may send a sample to the lab to check for cancer cells.
In some cases surgeons have to remove part of the bowel. They will usually only have to do this if the cancer has spread there and is blocking the bowel. They may have to create an opening (stoma) on the outside of the abdomen for bowel movements to come out into a bag. This is called a colostomy. This is often only temporary. The surgeon can do another smaller operation to close the stoma up again once everything has settled down from your first operation. There is more information about this in the section on treating advanced ovarian cancer. Below is a diagram showing a colostomy with a bag.
If your surgeon thinks it is possible to remove all or most of your cancer, you will have surgery before your chemotherapy. But if it would be difficult for the surgeon to remove enough of the cancer, you may have chemotherapy first. In this case, you have a biopsy of the tumour first to confirm the diagnosis, followed by chemotherapy and then surgery. This is called neo adjuvant chemotherapy (this is pronounced nee-oh-ad-joo-vent) or primary chemotherapy.
The chemotherapy may shrink the tumour so that it is then possible for the surgeon to remove it. You will have the rest of your chemotherapy after the operation. This operation is called interval debulking surgery (IDS).
You may also have IDS if you have already had surgery as your first treatment. You have this done if your surgeon couldn't remove enough of the cancer during your first operation or if it was done by a non specialist surgeon. So in this case, you have surgery first. Then you have some chemotherapy, followed by the second operation to remove the rest of the cancer, followed by more chemotherapy.
Your surgeon will need to be sure you are fit for your operation. You may have had some of these general tests when your cancer was being diagnosed. If so, you won't need to have them again. You will probably have
- A chest X-ray
- Blood tests
- Urine test
- ECG (heart monitor)
You will have an appointment before your operation where you meet the surgical team members and they will arrange any tests that you need. You will usually have these tests done 1 to 3 weeks before your surgery. During this appointment, the surgeon will explain the operation to you and ask you to sign a consent form to say that you agree to have the surgery. The doctor should explain the form fully to you before you sign it.
When you go into hospital for your surgery, your anaesthetist and one of the surgical doctors will come and see you. Your nurse or a physiotherapist will talk to you about the breathing and leg exercises that you will need to do after surgery to prevent chest infections and blood clots in your legs. They will give you a pair of white elastic stockings, called anti thrombotic stockings. These help to prevent blood clots in your legs. You will also have blood thinning drugs, called anticoagulants, to help prevent blood clots. And you will have antibiotics to help prevent infections.
Below is a short video showing breathing and circulation exercises after surgery. Click on the arrow to watch it.
View a transcript of the video showing breathing and circulation exercises after surgery (opens in new window)
If you have not emptied your bowels that day, your nurse may ask you to have suppositories or an enema to clear out your bowel. This helps to avoid constipation after your operation.
Your doctor or nurse will tell you when you need to stop eating or drinking before your operation. This is called being nil by mouth. As a general guide, you may not be able to eat for 6 hours before your operation. You may be allowed to drink water up to 2 hours before.
When you wake up after your operation you will have a few tubes in place. You may have
- A drip (intravenous infusion) into a vein in your arm to give you fluids until you are eating and drinking again
- A tube (catheter) into your bladder to drain your urine
Your nurses will advise you about when you can start drinking and eating again. You should be able to eat and drink normally within a couple of days.
Feeling sick
Some people feel sick after a general anaesthetic. Painkillers can also make you feel sick. Do tell your nurse or doctor straight away. They can give you anti sickness medicines. If the medicines aren't working, it can help to change to another drug. Let the staff on the ward know if you feel sick.
You will almost certainly have some pain for the first few days after your operation. But there are many painkilling drugs you can have. If you are in pain it is important you tell the nurse or doctor as soon as possible. With your help, they will be able to find the right type and dose of painkiller for you.
Doctors often give painkillers by epidural after surgery for ovarian cancer. An epidural is a small tube into your back, which anaesthetic is pumped into. There is more information about different types of painkillers in our pain control section.
Getting up
The nurses and physiotherapist will get you up as soon as possible, maybe even the day of your operation. You should have your painkillers before you have to get out of bed. While you are still in bed, do the breathing and leg exercises you have been taught. This helps to stop chest infections and blood clots.
Going home
You usually go home about 3 to 4 days after your operation. Your wound is usually closed with dissolvable stitches and so do not need to be removed. Your doctor will let you know if you do have stitches or staples that need taking out. This is usually about 7 to 10 days after your operation. The nurse at your GP surgery can normally do this for you. Before you leave the ward, your nurse or doctor should tell you if they will phone you with any results or give you an appointment to come back and see them. Do say if you would prefer to have your results in a face to face meeting, rather than over the phone.
If you live alone, or might have difficulty managing when you return home, let the doctors and nurses know during your clinic appointment before your surgery. Then plans can be made to help you cope until you have recovered from the operation.
It takes time to get over a hysterectomy. It is a big operation. And it can affect you emotionally as well as physically. There is more about recovering from hysterectomy in the section about living with ovarian cancer.
Rated 5 out of 5 based on 69 votes
Question about cancer? Contact our information nurse team


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The Future of Classroom Education
CLASSROOM 21 | by Greg Limperis Instead of reviewing The Year in EdTech, instead of giving you the Best 100 Education Apps, let's do something different: let's look forward. We all have some idea of what's out there. Here are … Continue reading
Posted in trends Tagged 2012 edtech predictions, 7.85-inch iPad, chips in education, controversy, educrates, eLearningInnovation, ereader, EXOdesk, future of classroom education, Greg Limperis, Mimio, RFID, Samsung SUR40 for Microsoft, smaller iPad, tablet, TAP-it, Technology Integration in Education, technology professional development for teachers, the year ahead 4 Comments
Trends | Infographic: Tech Use on the College Campus
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Men's basketball
Despite this being a so-called "Game to Watch," I can't find evidence there was actually a reporter in attendance.
So you probably won't get anything but the nuts and bolts AP story until Tuesday's Buchtelite.
Anyhow, if you take a look at the stats, you'll see Akron did exactly what it intended. Caleb Green got his 32 points. No one else did much. Ken Tutt scored 11, only because he launched 15 shots, making four. A total of five Golden Eagles even scored.
Coming in, I thought 6-foot-10 juco center Shawn King might present matchup problems. He played 12 minutes and did not score.
It was good to see the team's leaders play well in an important game. Dru Joyce (10 points, six assists and six rebounds) and Romeo Travis (18 points, seven rebounds and five blocks) filled the stat sheet. It's hard to be good when your senior leadership, like Tutt in ORU's case, fails to make an impact in an important game.
I still think the Zips can play much better than this. They had 13 assists to 16 turnovers, which is the worst ratio I've seen from them in a while.
Women's basketball
The Zips (1-5) will play Lehigh (2-5) today at 2 p.m. at Rhodes Arena.
Congrats to Dan Kadar, the Buchtelite's sports editor, for winning the newspaper's College Pick'em League.
Kadar overcame Stark County Zip Alum in the final week.
I tied for sixth, but held a decent lead for the first half of the season. Then I forgot to make my picks one week. D'oh!
Still, Kadar is to be congratulated for his "untainted" win.


text:
Rice Pudding Deluxe
24 Sep 2009
Rice Pudding Deluxe is one of those dishes that is very delicious. I can assure you, this Rice Pudding Deluxe will make you crazy for all your life!!
|Cooked rice
|2 Cup (32 tbs)
|1⁄2 Teaspoon
|Canned crushed pineapple
|20 Ounce (Drained)
|Whipped cream
|1⁄2 Pint, beaten
Mix rice, salt, and pineapple until well blended.
Add most of whipped cream (reserve some for garnish); fold in gently.
Spoon into individual serving dishes; top with whipped cream.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1715 Calories from Fat 747
% Daily Value*
Total Fat 83 g127.7%
Saturated Fat 55.1 g275.3%
Trans Fat 0 g
Cholesterol 342.8 mg114.3%
Sodium 1037.5 mg43.2%
Total Carbohydrates 204 g68.2%
Dietary Fiber 6.7 g26.9%
Sugars 98.8 g
Protein 9 g18.9%
Vitamin A Vitamin C
Calcium 14.8% Iron 29%
*Based on a 2000 Calorie diet
Rice Pudding Deluxe Recipe


text:
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Group Since April 2, 2009
Join the group to start a discussion!
Group DescriptionThis is a group of photographers that live in and/or around the DC region. The blog, www.dcshotlist.com, pulls from this pool to feature photographers and/or photographs weekly.
This group is restricted to DC regional photographers only, so please inquire about an invite.
Additional Info
- Accepted content types: Photos, Videos, Images, Art, Screenshots
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text:
There is nothing wrong with you wanting a lover
There is nothing strange about you wanting more
There is nothing weird about you trying to prove that there is more life can offer
Come a little closer whatever you are
I am telling the DJ to play it a bit louder
You have not yet said your name
You must think I m just a little crazy
But trust me this is not a game
I am not after fame
You know you will be down
But we cant have all these people staring and standing around
But this one here is only for your eyes to see
None of this is to have me being seen
But you being beside me drive me sane
As strong as the feeling is
Don't let it disappear into the forest of fears
A new year comes after many years
Lean on it
Yeah! Go on and take your time
This is what the voice within is telling you
Do you see the light coming out of it?
right you are in love
let the poetry Bite your lips, who don't like that lady truth when she is a little bit provocative
And it is just a synonym for being seductive
Let it breathe on your neck
But don't let it switch off the light; it is never honest in the dark
This right here is only for the pure in heart
Those who know that love is all about making space
This is for the one who can hold a conversation without having to be controlling
They don't need the world approval
Because what they live is eternal
And eternal is nothing because it is no thing
It start like a seed, here it looks like a tree with fruits to eat
poetry has been stuck in our mind like the greatest melody
No need to think about eden, her presence erase the feeling of time and shame and brings eternity
I am not talking about having my hands stuck in your what I wrote
I am saying about making our love life a success
Be my partner in this slow process
© Copyright 2017 alhain. All rights reserved.
Status: Finished
Genre: Poetry
and putting it very nicely, liked it - cool and complex...you have a particular style that is growing on me:)
Book / Religion and Spirituality
Book / Memoir
Short Story / Humor
Paste the link to picture in the entry below:
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text:
From Pearl's Catster Photos[ View profile page ]
While the spouts are pawsome, I quite like the 2-3 combo the best!
Your cat loves a clean toilet -- don't we all? Catster's singing Cat Lady, Sarah Donner, explains why.24
October 24th 2009 at 11:34 pm
Copyright © I-5 Publishing, LLC. All rights reserved.


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Markus Jelsma <markus.jel...@buyways.nl>
|RE: Re: MoreLikethis and fq not giving exact results ?
|Tue, 07 Sep 2010 22:15:56 GMT
I know =) I was just polling votes for a feature request - there is no such issue filed for this component. Perhaps there should be? -----Original message----- From: Chris Hostetter <firstname.lastname@example.com> Sent: Wed 08-09-2010 00:13 To: firstname.lastname@example.com; Subject: RE: Re: MoreLikethis and fq not giving exact results ? i don't disagree with you -- i was just commenting that it doesn't work that way at the moment, because it was designed with differnet use cases in mind (returning docs related to the result docs, independent of how you found those result docs) -Hoss -- http://lucenerevolution.org/ ... October 7-8, Boston http://bit.ly/stump-hoss ... Stump The Chump!
|View raw message


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text:
What is ground chuck (ground beef)? About the cooking ingredient ground chuck (ground beef). Including 43 recipes, nutrition data, and where to find it.
Ground chuck (ground beef) is usually found in the meats section or aisle of the grocery store or supermarket.
Ground chuck (ground beef) is a member of the Beef Products USDA nutritional food group.
|1 lb
|1 oz
|In Chinese:
|British (UK) term:
|Ground chuck (ground beef)
|en français:
|rez-de-mandrin (boeuf haché)
|en español:
|carne molida (carne molida)
There are 43 recipes that contain this ingredient.
|Usda nutrition data
|about 2 years ago
Created: Last updated:
- or use -
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Join now for FREE!


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Showing 97-192 of 238 items
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"The Best Motel by a Dam Site" located across from the Lake Shelbyville Dam, on the Kaskaskia River. Twenty-One 2-3 bed units with Wi-Fi, microwave, refrigerator, TV, hair dryer, Jacuzzi suite available. All rooms are ground floor. Free electric hook-ups for over 30 boats. Excellent location for fisherman, boaters, water skiers, sunbathers, picnickers and passers by. Bait Shop.
5 rooms, non-smoking, credit cards accepted, small meeting rooms, restaurant within walking distance.
This hotel is only 30 miles from O'Hare International Airport and a short drive to Naval Station Great Lakes. Get the best of your stay and visit Six Flags Great America, located only 1,000 feet across from the hotel. Each room comes with convenient amenities to help save travel time including free Wi-Fi internet access, 39-inch HDTV's, micro-fridge combo, heated indoor pool & hot tub.
Whirlpool suite, no pets, HBO, ESPN, CNN. River Oaks Shopping Mall and numerous restaurants nearby. 30 Minutes to Midway Airport and Purdue University Calumet is only 5 miles away. Downtown Chicago in 25 minutes.
Relax, renew and recharge at the AmericInn of Princeton Illinois, conveniently located at the intersection of Interstate 80 (exit 56) and Route 26. Our comfortable guest rooms are equipped with wireless high-speed Internet access and 32" flat LCD, HD satellite televisions. All guest rooms are equipped with a refrigerator and microwave. Also available are seven luxurious whirlpool suites, all decorated in different themes, including four with fireplaces
Super 8 chain.
48 rooms, including ones with microwaves and refrigerators. Truck parking available. Restaurants nearby. Handicap rooms, pet friendly.
Days Inn & Conference Center - Mattoon
123 room facility located in Mattoon, IL. Located just off Interstate 57 and a short drive from Charleston, Eastern Illinois University, Lake Shelbyville, Tuscola and Amish Country.
52 rooms, super start breakfast from 6am-10am, Olympic-size jacuzzi.
Best Western Plus Green Mill Village Hotel & Suites
Beautiful brand new hotel and conference center that has 68 rooms and suites available and features over 4,000 square feet of meeting and banquet space. Indoor pool, deluxe fitness center and easy on and off access to I-57. Located at 917 Green Mill Rd.
63 rooms are available. CableTV with HBO, queen and king size beds and air conditioning . Restaurants nearby. Reasonable rates.
Bed and breakfast with a beautiful, quiet country setting on a heavily wooded three acre lot. Breakfasts include international recipes. Charger ports for electric cars.
Fifty-room hotel. Minutes from downtown Woodstock.
32 rooms. King-size beds available. Honeymoon and kitchenette suites or handicap rooms available.
Comfort Inn is conveniently located in Crystal Lake with easy access to Route 14. The pet-friendly hotel features an indoor pool, meeting room and complimentary hot breakfast. All of the rooms offer soft and firm pillows, irons, ironing boards and hairdryers. There are also suites with whirlpool bathtubs, sofa sleepers, microwaves, coffee makers and refrigerators.
CITY:Crystal Lake
Free continental breakfast. Free local calls. Cable TV with Showtime and pay-per-view available.
Americas Best Value Inn & Suites - Matteson
The Americas Best Value Inn & Suites in Matteson guarantees high quality accommodations, friendly & efficient service, and clean, comfortable surroundings. Every guest feels that this is their "home away from home."
57 rooms, 3 suites, pets welcomed
Impeccably kept, older property with 45 units on 2 stories, exterior corridors, free continental breakfast, free parking.
This beautiful two story early 1880s home has four sleeping rooms available with a shared bath. The decor has lots of charm and elegant taste. The facility also is available for parties, showers, teas and family events - reservations needed. Meals served by reservation only, including full service breakfast. Handicap accessible. Pets accepted.
Always a friendly, warm comfortable place, the new Elizabeth Inn in Freeport serves guests traveling in the area with 50 well appointed rooms, both smoking and non-smoking, free wireless high speed internet access, cable TV, in room refrigerators, microwaves, irons and ironing boards, and hair dryers. Also exercise facilities, game room, on site laundry, pets allowed, and breakfast included. Indoor pool and whirlpool, restaurant, lounge, and banquet facilities will open in the future. Elizabeth Inn is committed to a comfortable, relaxing experience for all its quests at a budget friendly price.
Oswego 's newest lodging facility is the AmericInn Lodge & Suites featuring the unexpected charming lodge feel thought-out. Conveniently located in Mason Square on Douglas Road . Whether on business or pleasure the high quality beds and pillows to the INN-hanced Continental Breakfast Buffets big Belgian Waffles to the "Bears" will capture your attention. Other amenities include the large vaulted ceiling pool area, FREE high speed internet throughout with wireless option, fully supplied Business Center and Fitness Center, conference ability all enhanced with natural Hickory woodwork and Amish handcrafted accent furniture in all public areas and sleeping rooms. The (14) different room styles such as Business King, Deluxe Double Queens some with spa's, fireplaces, extended stay, two rooms or oversized rooms will meet any and all needs
2-story facility. Upper level is three efficiency units equipped with microwave, refrigerator, and stove. Monthly and nightly rates available.
Feel at home at Hampton Inn – Joliet I-80. Conveniently located off of I-80 and Houbolt Rd, you'll find a warm welcome and award winning customer service. This Joliet hotel is within ten minutes of downtown Joliet IL and near two riverboat casinos.
An 1870 era, traditional brick home overlooking Galena and the scenic countryside. Two guest rooms, one suite. Full breakfast, A/C, cable TV in parlor. Limited smoking. Senior, off-season, multi-night discounts are available.
Get the rest you need after a long day on the road at our Super 8 Jerseyville hotel. Located on Illinois State Route 109, less than one hour from St. Louis, MO, our hotel makes it easy to enjoy small-town charms with convenient access to big-city excitement. Enjoy queen size beds, recliners in most rooms, satellite TV, free local calls, jacuzzi bathtubs in selected rooms.
83 guest rooms, including single-studio suites, double queen suites and one bedroom suites. Suites include fully equipped kitchens with full-size refrigerator and icemaker, dishwasher, microwave and stovetop plus a variety of dishes, cookware and utensils. Suites also include spacious work area with two-line phone and free high-speed Internet access. Perfect location for business, leisure and extended-stay travelers.
Newly Renovated Hotel Property, Outdoor Pool, Free High Speed Wireless Internet, Free Coffee, Pets Are Welcome, 3 Miles From Six Flags Great America, The Great Lakes Naval Training Center And Gurnee Mills Mall.
America's Best Value Inn & Suites - Waukegan
Indoor Heated Pool, Free Wireless Internet, Free Continental Breakfast, all rooms with refrigerator, iron/ironing board, hair dryer, and coffee makers.
28 room motel, credit cards accepted, cable television. restaurant witnin walking distance.
This 61 room facility is located just off I-57 and Illinois Route 16, and has a variety of restaurants within walking distance. Attractions nearby include the Lincoln Log Cabin State Historic Site and the Lincoln-Douglas Debate Museum. Free Wi-Fi, business center, free breakfast bonanza, and pet-friendly. Kids 17 and under stay free with an adult.
Super 8 Motel in Princeton offers a seasonal heated pool, queen beds, HBO, CNN, ESPN, laundry facilities, hot tub suites and high speed internet. See you along the way. Take Exit 56 of I-80 then North
Baymont Inn & Suites - Mattoon
Consider our Baymont Inn & Suites Mattoon hotel your home base during your stay in Mattoon. Conveniently located off Interstate 57, the hotel is just minutes away from local destinations like Lake Mattoon, Fox Ridge Park and Rockome Gardens. Each guest room comes with homestyle amenities to make your stay relaxing. Take advantage of amenities like free Wi-Fi Internet access and our heated indoor swimming pool and hot tub. After a peaceful rest, start your day with free continental breakfast before starting your Illinois adventure.
Extended Stay America - State Street
Full kitchens in all rooms, in-room wireless Internet access. Conveniently located just off I-90 and Business Rt. 20. Near Magic Waters waterpark, CherryVale Mall, antique shops, OSF Saint Anthony Medical Center.
Best Western offers free breakfast, pool & spa, non-smoking and smoking rooms, and is pet friendly. If you want to go out diner you don't have to travel to far, because the Raintree Restaurant is located next door and it is owned by the same family.
Paradise Inn is a clean, well-maintained hotel. The hotel allows small pets, has cable and bus parking, and is adjacent to restaurants.
2-story facility. Indoor pool. Handicap accessible and pet friendly.
Facility is one story with all outside entrances. 20 rooms available. Pet friendly.
Stay just minutes from Chicago Premium Outlets, Paramount Theatre, Two Brothers Roundhouse and Hollywood Casino Aurora. 71 newly renovated rooms with complimentary Wi-Fi, refrigerator, microwave, 39" LED TV. Indoor pool and fitness center. Pet friendly with deposit.
CITY:North Aurora
Welcome travelers, wayfarers and refined persons. Celebrating 100 years, this historic inn is on the Courthouse Square in Hillsboro. Restaurant and bar at the facility.
22 rooms, Credit cards accepted, cable television available, and a restaurant within walking distance.
43 rooms, sits back-to-back with Comfort Inn, semi parking available, all major credit cards accepted, no checks please. Free cable/HBO, and free local and 1-800 calls.
Award-winning motel with 41 newly renovated guest rooms. A themed hot tub suite. Free continental breakfast, 24-hour coffee, hair dryers, irons and ironing boards. Free local calls, microfridges, cable TV with free HBO, bus and truck parking, outside outlets.
The Super 8 has 42 rooms, some with whirlpool tubs. Complimentary continental breakfast, free local calls, cable TV. Major credit cards accepted.
Americas Best Value Inn & Suites - Waukegan/Gurnee
This hotel is known for its friendly, spacious and comfortable environment and is located a few miles from Six Flags, Gurnee Mills, Great Lakes Naval Training Center, downtown Waukegan, area attractions and the best sport facilities.
Conveniently located off Interstate 55 at - less than 30 minutes south of Springfield attractions. Enjoy close proximity to shops and dining in downtown Litchfield, historic Route 66 attractions and outdoor recreation on Lake Lou Yaeger. Facility has 61 rooms with 2 suites. Free Wi-Fi and kids 17 and under stay free.
Red Roof Inn Chicago Downtown Magnificent Mile
Surprising luxury at affordable rates! From our beautiful exterior to our fashionably remodeled lobby and guest rooms, Red Roof Inn - Chicago Downtown boasts Windy City convenience at surprisingly suburban rates.From designer fabrics and furnishings to friendly staff willing to help you explore our exciting hometown, Red Roof Inn - Chicago Downtown offers even more reasons for you to stay with us!
Hotel offers a variety of rooms from standard double queen rooms to king and whirlpool tub suites. Relax in the hotel indoor heated pool and whirlpool or host your next meeting in our executive conference room.
Americas Best Value Inn - West Frankfort
The inn is located right on Factory Outlet Blvd. It is close to many attractions, shopping destinations, and restaurants. Complimentary wireless hi-speed Internet access is available for all guests. They offer large suites and rooms with one or two beds.There are rooms furnished for handicap access also available and some rooms have exterior access. Just walking distance from the Factory Outlet Mall.
CITY:West Frankfort
Enjoy a wealth of amenities at an affordable price when choosing the smoke-free Sleep Inn & Suites® hotel in Danville. The pet-friendly hotel is conveniently located just off of Interstate 74 and in close proximity to Kickapoo State Park, Kennekuk County Park, Danville Area Community College, the David S. Palmer Arena, and VA Illiana Health Care System.
Centrally located to Vernon Hills, Lincolnshire and Deerfield corporate centers, Great Lakes Navy Base, Six Flags Great America/Hurricane Harbor and Gurnee Mills Mall Outlet Shopping Center. This Lake Forest hotel features170 rooms, each equipped with complimentary high-speed internet access, flat screen TV, microwave, refrigerator and coffeemaker. Relax in the indoor pool, whirlpool or work out in the exercise facility. The on-site restaurant serves breakfast, lunch, dinner and evening room service. An exceptional meeting and banquet space for business and corporate meetings, intimate wedding receptions, family reunions, military reunions, or religious retreats is also available.
An upscale limited service property. Free high speed internet in all rooms, free enhanced continental breakfast, lobby business center and a variety of room types including whirlpool & fireplace suites.
Pride of Super 8 Award. Complimentary USA TODAY. Copy and fax machine. Free local calls. HBO and SVI movies. Continental breakfast 6 a.m.-10 a.m.
63 rooms and a free toast bar. Some facility amenities include free parking, pets allowed, and complimentary breakfast.
Nine-unit motel on Highway 20. New 32" flat screen TVs with cable, credit card phone service, nearby café. Midweek/multi-night discounts. Visa/MasterCard. No pets. Non-smoking. Amenities in office. Coffeemaker, microwaves, refrigerators.
Conveniently located near Springfield and the historic Old Route 66. Litchfield Lake Lou Yeager boasts a beautiful lake, nature trails and picnic areas. There are a variety of restaurants nearby.
23 unit hotel. Restaurant facility on location. Room service and cableTVv offered. Phones in the rooms. Weekly rates offered.
Galena's Value Motel. Offering simple comforts of home: one-three beds/room, mini fridges, convenient parking. Laundry/kitchen facilities. Fitness equipment. Gas grills, picnic pavilion, volleyball, bean bags. Dog-friendly. Spacious backyard, scenic views.
Rodeway offers standard amenities, along with microwaves, refrigerators, coffee makers, and cable television. Whirlpool bathtubs, sofa sleepers and spacious work desks are available in some rooms. A continental breakfast is also provided.
The Best Western Regency Inn in Danville offers the best in service and hospitality with convenient access off Interstate 74 at exit 220.Guests are just minutes away from Danville's corporate, industrial, and leisure areas and are ideally located near area shopping and attractions including Kickapoo State Park, Kennekuk County Preserve, David S. Palmer Arena and many historic sites.
Conveniently and centrally located the Americas Best Value Inn proves to be a great starting point for those visiting historic Mt. Vernon. The property is a four story, exterior corridor facility with spacious guestrooms.
CITY:Mount Vernon
Queen-size beds, HBO, ESPN, cable TV, free continental breakfast, guest laundry, children stay free with parents. Pets allowed with permission.
55 rooms, non-smoking, handicapped accessible, credit cards accepted, cable television available, indoor pool, whirlpool, restaurant within walking distance, and a complimentary breakfast served.
CITY:Fairview Heights
1-story Butler type building with outside entrances and inside doors to ice and pop machines.
CITY:Mount Sterling
13 rooms, restaurants nearby, and free movie channel.
Located just off I-57 at Benton Exit, this modern motel extends the traveler 48 clean rooms, free morning coffee and convenient restaurant and lounge on premises. Special packages for hunters and fishermen.
The Welcome Inn conveniently located in downtown Quincy overlooking the Mississippi River. Also offering extended stays and within walking distance to downtown shopping and dining and is one block from the Oakley Lindsay Civic Center. Serving a hot breakfast daily with affordable rates and a large outdoor pool.
70-room property with clean and comfortable accommodations. Featuring coin-operated laundry facilities, remote controlled TV, Free HBO, SHOWTIME and ESPN. Free local calls
52 rooms and 4 suites; King size suites; non-smoking available; truck parking; in-house laundry facilities. Handicap rooms. Pet friendly.
28 rooms, handicapped accessible, credit cards accepted, and cable television available.
Indoor pool, Jacuzzi suites, free high-speed internet, complimentary breakfast, guest laundry.
28 rooms, 18 rooms completely new. Enjoy a meal at Three Stars Family Restaurant.
Affordable rooms with continental breakfast, cable TV, and large vehicle parking.
Large comfortable rooms with queen-size beds. Only 10 minutes from Galena. Meet new friends around outdoor fireplace. Complimentary coffee/tea. Special group rates. New 26-inch flat-panel HDTVs with satellite. Free Wi-Fi.
The perfect rest stop at the end of a busy day. Complimentary continental breakfast, free local calls, free cable and special facilities for physically challenged travelers.
Close to Great Lakes, Six Flags Great America, and Gurnee Mills. We also offer a deluxe continental breakfast. www.The.DaysInn.com/Libertyville13906
Built in 1993 located just off the toll-way. Very convenient location with a friendly staff eager to help guests. Spa suites make a perfect weekend getaway. Amenities include: Indoor Pool, Free Continental Breakfast, Handicapped Accessible, Pet Friendly, Wi-Fi Access, Guest Laundry
Located on Highway 1 off Interstate 70. Your stay includes free breakfast bonanza, free Wi-Fi Internet, free parking including for truck and RV, and pet friendly. Hot tub rooms are also available. Attractions nearby include Twin Lakes Park and Bicentennial Art Center & Museum.
48 rooms with double beds. Cable TV wtih HBO & ESPN. Direct dial phones, local calls are free.
32 units with double-queen size beds. Locally owned. Free complimentary breakfast, HBO-cable
81 rooms, pets allowed, complimentary breakfast
CITY:Fairview Heights
Welcome to the Super 8 Pinckneyville. We offer 47 Rooms, as well as Indoor heated Pool, Banquet Facility for up to 75 persons, Interior Corridors, 27 inch Televisions, Exercise Room, Free local calls.
26 rooms, some with kitchenettes. Handicap rooms, pet friendly.
Town and Country Inn and Suites
93 room hotel with a wide variety of rooms and suites. Rooms with microwaves and refrigerators are available. All rooms have coffee makers. Complimentary expanded continental breakfast Hi Speed Internet 300 room banquet hall – two smaller meeting rooms – full service catering available Indoor Pool Exercise Room Lounge with limited hours Whirlpool suites Two room suites Adjoining rooms
63 rooms, complimentary breakfast, restaurant within walking distance
This 67-room hotel offers suites; handicapped and non-smoking rooms; indoor pool; exercise facilities, cable TV with HBO; free highspeed internet; in room phones with a second line; iron and ironing boards; coffee makers; deluxe continental breakfast. AARP, group, and multiple night discounts. American Express, Discover, Mastercard, Visa.
Motel offers clean rooms for your stay.
This motel offers affordable rates with a location close to I-57. It features clean and spacious guest rooms with cable television. Senior rooms are offered. Non-smoking rooms are also available.
Newly remodeled; rooms with kitchenettes; others with microwave and refrigerators; cable television, free HBO and free local calls.
A fourty plus room motel with many amenities travelers seek.
Experience a fun, comfortable stay. Free continental breakfast. Clean rooms, affordable rates.
Newly remodeled, 21 rooms. Singles and doubles. Carport parking. Pet friendly.
63 rooms located close to I-57.
CITY:Mount Vernon
This recently opened facility presents an excellent accommodation for the traveler.
42-room motel with cable TV, restaurants in immediate area and complimentary breakfast.
Super 8 chain.


text:
Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children
- Hector R Wong1, 2Email author,
- Natalie Z Cvijanovich3,
- Mark Hall4,
- Geoffrey L Allen5,
- Neal J Thomas6,
- Robert J Freishtat7,
- Nick Anas8,
- Keith Meyer9,
- Paul A Checchia10,
- Richard Lin11,
- Michael T Bigham12,
- Anita Sen13,
- Jeffrey Nowak14,
- Michael Quasney15,
- Jared W Henricksen16,
- Arun Chopra17,
- Sharon Banschbach1,
- Eileen Beckman1,
- Kelli Harmon1,
- Patrick Lahni1 and
- Thomas P Shanley18
DOI: 10.1186/cc11847
© Wong et al.; licensee BioMed Central Ltd. 2012
Received: 17 July 2012
Accepted: 26 October 2012
Published: 29 October 2012
Differentiating between sterile inflammation and bacterial infection in critically ill patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) remains a clinical challenge. The objective of our study was to mine an existing genome-wide expression database for the discovery of candidate diagnostic biomarkers to predict the presence of bacterial infection in critically ill children.
Genome-wide expression data were compared between patients with SIRS having negative bacterial cultures (n = 21) and patients with sepsis having positive bacterial cultures (n = 60). Differentially expressed genes were subjected to a leave-one-out cross-validation (LOOCV) procedure to predict SIRS or sepsis classes. Serum concentrations of interleukin-27 (IL-27) and procalcitonin (PCT) were compared between 101 patients with SIRS and 130 patients with sepsis. All data represent the first 24 hours of meeting criteria for either SIRS or sepsis.
Two hundred twenty one gene probes were differentially regulated between patients with SIRS and patients with sepsis. The LOOCV procedure correctly predicted 86% of the SIRS and sepsis classes, and Epstein-Barr virus-induced gene 3 (EBI3) had the highest predictive strength. Computer-assisted image analyses of gene-expression mosaics were able to predict infection with a specificity of 90% and a positive predictive value of 94%. Because EBI3 is a subunit of the heterodimeric cytokine, IL-27, we tested the ability of serum IL-27 protein concentrations to predict infection. At a cut-point value of ≥5 ng/ml, serum IL-27 protein concentrations predicted infection with a specificity and a positive predictive value of >90%, and the overall performance of IL-27 was generally better than that of PCT. A decision tree combining IL-27 and PCT improved overall predictive capacity compared with that of either biomarker alone.
Genome-wide expression analysis has provided the foundation for the identification of IL-27 as a novel candidate diagnostic biomarker for predicting bacterial infection in critically ill children. Additional studies will be required to test further the diagnostic performance of IL-27.
The microarray data reported in this article have been deposited in the Gene Expression Omnibus under accession number GSE4607.
Differentiating between sterile inflammation and bacterial infection in critically ill patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) remains a clinical challenge [1–3]. Standard microbiology culture techniques remain the gold standard, but they can lack sensitivity, and often, a substantial delay occurs between obtaining cultures and generating clinically useful data. Consequently, a great deal of interest exists in developing biomarkers to differentiate sepsis from noninfectious causes of SIRS before microbiology data become available [4].
We generated a large genome-wide expression database (transcriptomics) of critically ill children with SIRS, sepsis, and septic shock by way of microarray technology [5–18]. In the current study, we mined these data to discover gene signatures having the potential to differentiate sepsis from noninfectious causes of SIRS. Herein we report that interleukin-27 (IL-27) may represent a novel diagnostic biomarker for predicting bacterial infection in critically ill patients.
Materials and methods
Patients and data collection
The study protocol was approved by the Institutional Review Boards of each participating institution (n = 17) and was previously described in detail [14, 18]. In brief, children 10 years of age or younger admitted to the pediatric intensive care unit (PICU) and meeting pediatric-specific criteria for SIRS, sepsis, or septic shock were eligible for enrollment [19]. After informed consent from parents or legal guardians, we obtained blood samples within 24 hours of initial presentation to the PICU with SIRS, sepsis, or septic shock. Clinical and laboratory data were collected daily while patients were in the PICU, and stored by using a Web-based database. Mortality was tracked for 28 days after enrollment, and organ-failure data were based on pediatric-specific criteria [19]. Control samples were obtained from healthy children in the ambulatory departments of participating institutions by using previously published inclusion and exclusion criteria [18].
All patients with microarray data in the current study were previously reported in studies addressing hypotheses entirely different from that of the current report [7, 9–16, 18, 20]. For the current study, all patients in the sepsis and septic-shock cohorts had clinical microbiology laboratory confirmation of a bacterial pathogen from blood cultures or other normally sterile body fluids, whereas all patients in the SIRS cohort had negative bacterial cultures.
RNA extraction, microarray hybridization, and microarray analysis
Total RNA was isolated from whole-blood samples by using the PaxGene Blood RNA System (PreAnalytiX; Qiagen/Becton Dickinson, Valencia, CA, USA) according the manufacturer's specifications. Microarray hybridization was performed by the Affymetrix Gene Chip Core facility at Cincinnati Children's Hospital Research Foundation, as previously described, by using the Human Genome U133 Plus 2.0 GeneChip (Affymetrix, Santa Clara, CA, USA) [18].
Analyses were performed by using one patient sample per chip. Image files were captured by using an Affymetrix GeneChip Scanner 3000. Raw data files were subsequently preprocessed by using Robust Multiple-array Average (RMA) normalization with GeneSpring GX 7.3 software (Agilent Technologies, Palo Alto, CA, USA) [21]. All chips were then normalized to the respective median values of normal, age-matched controls, as previously described [18]. Differences in mRNA abundance between patient samples were determined by using GeneSpring GX 7.3. All statistical analyses used corrections for multiple comparisons. The specific statistical and filtering approaches for identifying differentially regulated genes are provided in the Results section because of their relevance to data interpretation. All microarray data have been deposited in the Gene Expression Omnibus [22] under accession number GSE4607.
Generation of gene-expression mosaics
Gene-expression mosaics were generated by using the Gene Expression Dynamics Inspector (GEDI) platform. GEDI is a publicly available gene-expression analysis program developed by the Ingber Laboratory at Harvard University [23, 24]. The signature graphic outputs of GEDI are gene-expression mosaics that give microarray data a "face" that is intuitively recognizable by human pattern recognition [10, 11]. The underlying algorithm for creating the mosaics is a self-organizing map (SOM).
Computer-assisted image analysis
Individual patient mosaics were compared with SIRS and sepsis reference mosaics by using a publicly available image-analysis platform (ImageJ), as previously described [10]. In brief, the absolute difference in RGB pixel-to-pixel intensity was calculated for each individual patient mosaic relative to the SIRS and sepsis reference mosaics. Final classification was based on the "least difference" between the individual patient mosaic and the two reference mosaics.
Measurement of IL-27 and procalcitonin serum protein concentrations
Serum IL-27 (EMD Millipore Corporation, Billerica, MA, USA) and procalcitonin (Bio-Rad, Hercules, CA, USA) protein concentrations were measured by using a magnetic bead multiplex platform and a Luminex 100/200 System (Luminex Corporation, Austin, TX, USA), according the manufacturers' specifications.
Statistical analysis
Initially, data are described by using medians, interquartile ranges (IQRs), and percentages. Comparisons between study cohorts used the Mann-Whitney U test, χ2, or Fisher Exact tests, as appropriate. Descriptive statistics and comparisons used SigmaStat Software (Systat Software, Inc., San Jose, CA, USA). Classification and regression tree (CART) analysis was conducted by using the Salford Predictive Modeler v6.6 (Salford Systems, San Diego, CA, USA) [25]. Biomarker test characteristics are reported by using diagnostic test statistics with 95% confidence intervals computed by using the score method, as implemented by VassarStats Website for Statistical Computation [26].
Initial identification of candidate sepsis diagnostic genes
Clinical characteristics of the gene-expression cohort
SIRS (n= 21)
Sepsis (n= 60)
Median age in years
3.3 (2.0 to 8.3)
1.9 (0.6 to 5.1)a
Males (%)
Median PRISM score
10 (4 to 14)
14 (10 to 21)a
Mortality (%)
The initial step for identifying candidate sepsis diagnostic genes consisted of an expression filter. Starting with all gene probes on the array (>80,000), we selected gene probes having ≥2-fold expression between the median values of patients with sepsis and patients with SIRS, respectively. This expression filter yielded 228 gene probes. We next subjected the 228 gene probes to a statistical test (ANOVA with a Benjamini-Hochberg false-discovery rate of 5%) by using the sepsis and SIRS cohorts as the comparison groups. This statistical test yielded 221 gene probes differentially regulated between patients with sepsis and patients with SIRS.
We then performed a leave-one-out cross-validation (LOOCV) procedure to determine whether the overall expression patterns of the 221 differentially regulated gene probes could identify SIRS and sepsis classes. The LOOCV procedure correctly predicted 86% of the SIRS or sepsis classes. The top 100 class-predictor genes (based on predictive strength) are provided in Additional file 1. Epstein-Barr virus-induced gene 3 (EBI3) had the highest predictive strength.
Gene-expression mosaics of the top 100 class-predictor genes
Test characteristics of gene-expression mosaics for identifying sepsis versus systemic inflammatory response syndrome (SIRS)
95% Confidence interval
Positive predictive value
Negative predictive value
IL-27 as a diagnostic biomarker for bacterial infection in critically ill patients
As previously noted, EBI3 had the highest predictive strength for bacterial infection in this cohort of critically ill children. EBI3 is a subunit of the heterodimeric cytokine, IL-27, which is produced by antigen-presenting cells and plays a role in regulating T-cell function [27]. Because IL-27 protein concentrations can be readily measured in the serum compartment, we tested IL-27 serum protein concentrations as a diagnostic biomarker for bacterial infection in critically ill children.
Clinical characteristics of the interleukin-27 cohort
Controls (n= 61)
SIRS (n= 101)
Sepsis (n= 38)
Septic shock (n= 92)
Median age in years
4.3 (1.2-6.5)
3.8 (1.2-6.4)
1.3 (0.4-5.3)a
2.4 (0.9-5.8)
Males (%)
Median PRISM score
7 (2-11)
7 (5-13)
14 (8-21)b
Mortality (%)
Median IL-27 (ng/ml)
1.0 (0.7-1.6)d
2.5 (1.6-3.7)e
6.1 (3.6-9.5)
5.9 (3.2-10.9)
Median PCT (ng/ml)
1.3 (0.1-2.4)
1.8 (0.1-4.9)
6.1 (2.7-20.5)b
Interleukin 27 (IL-27) test characteristics for predicting bacterial infection
Cut point ≥ (ng/ml)
Positive predictive value
Negative predictive value
92% (86-96)
35% (26-45)
65% (58-72)
78% (62-88)
79% (71-86)
60% (50-70)
72% (64-79)
69% (58-78)
69% (61-77)
82% (73-89)
83% (75-90)
67% (58-75)
61% (52-69)
92% (84-96)
91% (82-96)
64% (56-72)
51% (42-60)
96% (89-99)
94% (85-98)
60% (52-68)
Comparison with procalcitonin
Procalcitonin (PCT) test characteristics for predicting bacterial infection
Cut point ≥ (ng/ml)
Positive predictive value
Negative predictive value
88% (81-93)
30% (21-40)
62% (55-69)
67% (51-80)
85% (77-90)
37% (28-47)
64% (56-71)
65% (51-77)
70% (61-78)
62% (52-71)
70% (62-78)
61% (51-71)
63% (54-71)
82% (73-89)
82% (73-89)
63% (54-71)
56% (47-65)
87% (78-93)
85% (75-91)
60% (52-68)
Combining IL-27 and PCT
We previously reported differential patterns of gene expression across the SIRS, sepsis, and septic-shock clinical spectrum [14]. In that previous study, however, the classifications of "sepsis" and "septic shock" were based on either laboratory confirmation of a pathogen, or high clinical suspicion of infection, according to published, pediatric specific criteria [19]. The current analysis is specifically targeted toward identification of patients with signs of inflammation and laboratory confirmation of a bacterial pathogen. Accordingly, all of the patients in the current study who met criteria for sepsis and septic shock also had laboratory confirmation of a bacterial pathogen.
Based on this analytic approach, we leveraged the discovery potential of microarray-based transcriptomics and generated a list of genes differentially regulated between critically ill patients with SIRS (that is, patients with sterile systemic inflammation) and critically ill patients with sepsis (that is, patients with systemic inflammation secondary to a documented bacterial pathogen). This gene list represents a potential working list of candidate diagnostic biomarkers for bacterial infection in critically ill patients. The global expression patterns of the top 100 class-predictor genes were able to predict SIRS and sepsis classes with high specificity and a high positive predictive value.
Generating gene-expression data and gene-expression mosaics for 100 genes may not yet be clinically feasible within the time-sensitive constraints of the intensive care unit. Accordingly, we investigated the ability of serum IL-27 protein concentrations to predict bacterial infection in critically ill patients. The rationale for investigating IL-27 is based on the observation that EBI3 had the highest predictive strength for bacterial infection of all genes differentially regulated between patients with SIRS and patients with sepsis. IL-27 is a heterodimeric cytokine belonging the IL-6 and IL-12 family of cytokines and is composed of the IL-27-p28 and EBI3 subunits, which are produced by antigen-presenting cells on exposure to microbial products and inflammatory stimuli [27]. IL-27 is a regulator T-cells, having both pro- and antiinflammatory effects [28, 29], and is rapidly induced in a murine model of septic peritonitis [30]. Furthermore, genetic ablation of EBI3 or neutralization of IL-27 via a soluble IL-27 receptor fusion protein is protective in a murine model of septic peritonitis [30]. Thus, it is biologically plausible that IL-27 can serve as a biomarker of bacterial infection in critically ill patients.
Serum IL-27 protein levels ≥5 ng/ml, obtained within the first 24 hours of meeting clinical criteria for SIRS/sepsis, had a high specificity and a high positive predictive value for predicting bacterial infection in our cohort of more than 200 critically ill patients with SIRS or sepsis. Thus, serum IL-27 has the potential to serve as an effective "rule-in" test, given that concentrations ≥5 ng/ml had a >90% specificity and positive predictive value for bacterial infection in this cohort of critically ill patients. Conversely, serum IL-27 protein concentrations <5 ng/ml do not necessarily rule out bacterial infection, given that the negative predictive value for a concentration ≥2 ng/ml was 78%. Finally, it does not appear that increased IL-27 protein concentration in critically ill children with bacterial infection reflects increased illness severity, because the median IL-27 concentrations were similar between patients with sepsis and patients with septic shock.
PCT has emerged as a widely used diagnostic biomarker for bacterial infection in clinical practice. However, the performance of PCT varies depending on the patient population in which it is applied, and a meta-analysis by Tang et al. [1] concluded that PCT does not reliably differentiate sepsis from noninfectious causes of SIRS in critically ill adults. In our study population, PCT concentrations were not significantly different between patients with SIRS and patients with sepsis; and IL-27 generally performed better than PCT as a diagnostic biomarker based on the AUC and the test characteristics calculated for various cut points.
Given the biologic complexity and heterogeneity of critical illness, it is unlikely that any one biomarker will consistently predict the presence of bacterial infection. Accordingly, a strategy that combines diagnostic biomarkers may perform better than any single biomarker [2, 31]. With a combination of IL-27 and PCT, we were able to demonstrate an improved overall ability to both "rule in" and "rule out" bacterial infection in this cohort of critically ill patients.
Several strengths of our study design are worthy of discussion. First, we selected IL-27 as a candidate diagnostic marker in an objective manner, by using the discovery potential of transcriptomics. Second, our study cohort was relatively large, and all patients in the sepsis cohort had formal microbiologic confirmation of bacterial infection. Third, the study cohort represents patients from 17 different institutions. Finally, the serum IL-27 data reflect the first 24 hours of meeting criteria for either SIRS or sepsis, which is a clinically relevant time point for the prediction of bacterial infection in critically ill patients.
Our study also has a number of limitations worthy of discussion. First, although EBI3 mRNA levels had the highest predictive strength, we did not directly measure serum EBI3 protein concentrations, because it was technically more pragmatic to measure serum IL-27 concentrations. Second, EBI3 is also a subunit for IL-35, but we were unable to measure serum IL-35 concentrations for technical reasons. Third, we cannot exclude the possibility that some of the patients in the SIRS cohort had bacterial infections that were undetectable by conventional microbiologic cultures. Fourth, our data are limited to critically ill children and may not be generalizable to other clinical settings. Finally, we have no data regarding the temporal production of IL-27 during the course of bacterial infection. These limitations provide further research opportunities for future studies.
Genome-wide expression analysis has provided the foundation for the identification of IL-27 as a novel candidate diagnostic biomarker for predicting bacterial infection in critically ill patients. We also demonstrated that a combination of IL-27 and PCT improves the overall ability to predict infection, compared with that of either biomarker alone. Additional studies will be required to test further the diagnostic capabilities of IL-27.
Key messages
By using microarray analysis, we identified 221 gene probes that are differentially regulated between patients with SIRS and patients with sepsis.
The expression patterns of these differentially regulated gene probes can distinguish patients with SIRS and patients with sepsis with a high specificity and positive predictive value.
Epstein-Barr virus-induced gene 3 (EBI3), a subunit of IL27, has the highest predictive strength among the 221 differentially regulated gene probes.
Serum IL27 protein concentrations had a high specificity and positive predictive value for predicting bacterial infection in a cohort of critically ill children.
The performance of IL27 was generally superior to that of procalcitonin in this cohort.
area under the curve
classification and regression tree
Epstein-Barr virus-induced gene 3
Gene Expression Dynamics Inspector
interquartile range
leave-one-out cross validation
pediatric intensive care unit
pediatric risk of mortality
receiver-operating characteristic
systemic inflammatory response syndrome.
Supported by National Institutes of Health Grants RC1HL100474 and RO1GM064619 to HRW. Supported, in part, by the National Center for Advancing Translational Sciences, National Institutes of Health Grant UL1TR000040.
The authors thank the following research coordinators for their effort and dedication in enrolling study participants: Tasha Capozzi, Mary Ann De Liberto, Mercedes Galera-Perez, Kristin Greathouse, Lauren Hoadley, Katherine Luther, Stephanie Osborne, Amber Hughes-Schalk, Tonia Polanski, Julie Simon, Debra Spear, Lisa Steele, Naresh B. Talathoti, Tiffany Vertican, Monica Weber, Andrew A. Wiles, Trisha Williams, and Erin Zielinski.
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Would you like to save as your currency permanently or for this visit only?
We stayed 3 days it was nice my kids enjoy it alot, you have the pool and the beach right there,it was awsome, the location was great you have a big Boulevard of restaurants, cafe,a small mall...all in front of the beach... I did not like that you have to rent the chair and umbrella,of the beach that should be included,
Rooms need update. Lobby and the other parts of hotel have been updated.
View was fantastic. Front desk was excellent in getting our rooms near each other. Couldn't have asked for anything better. Guess the only thing I didn't like was paying $18 per day for parking whether you parked it yourself or used valet.
Location on the beach with easy access was nice. Also, I appreciated that they let you take pool towels onto the beach (at least I didn't see a sign telling you not to). It wasn't just the outdated room infested with ants that irritated me (not the biting kind; the ones that just seek out food residue). It was really the little things that pissed me off. Like in the bathroom, which seemed nice and updated but then you realize that the sink doesn't turn off. And the toilet paper holder doesn't fit the slots in the wall. Also, remember that their private beach is THEIR private beach, not yours. If you want to sit in a chair or have some water you must buy it from THEM. You can't bring your own. This is basically a $69 budget hotel in a great location which allows them to jack up the room rates.
Liked the pool and beach The rooms felt old, dated and carpet was old and smelly.
We really liked the atmosphere and the staff. Everyone was helpful and fun to talk too. The beach view is great! The Tiki bar was fun and efficient!
Rude night clerk that greeted us. Old food in the vending machine that only take chaneed or dollars no larger bill changers anywhere. If not for the night clerk they would have gotten 5 stars from me everyone else was extremely friendly.
Beach front location, relatively quiet . Bed was comfortable and seemed clean. , . - Room was very dark, old beaten up furniture, - very small sink area and bathroom, - air conditioner was not possible to shut off or adjust, it was unnecessary noisy and cold in the room. - terrible pillows, used my own travel pillow - Kind of very gloomy depressing room. - very cold inside lobby and restaurant. weather was rainy but staying inside was even worse
Good: on the beach location Not so good: daily parking fee
Loved the location. My husband and I really wanted to spend time at the beach and relax. Restaurant lighting is more cafeteria style and lacks ambience. Food was not good, burned & a major disappointment.
Not impressed with the overall condition.
Clean friendly staff. Drinks great! That I had to leave.
This hotel was an unexpected treat because has the original architecture, lighting and friendly staff without even trying to market their retro vibe. Reminds me of the hotels in the south florida mysterIes I love to read, Best part, I was a little worried because I was unfamiliar with the area, no problems at all, we even left our car unlocked without knowing. Great bar and fun bartender, make sure you ask the price of the "Skittle" shot offered before you order one or more!!!
The hotel was located across the street from the beach which was easily accessible. Many restaurants and clubs were nearby. Staff was helpful when we were in need of cab service. The bathroom, although small, had been recently renovated. The hotel is in need of updating. Many things were outdated. We felt the room was overpriced, although we were there during high season.
The staff was very friendly. I was happy to be close to the beach. For the money I paid, I was very far from the airport and any sort of night life. But that was definitely not the worst. I do not like to give bad reviews, but the room was hot and musty, the mattresses were covered in plastic and worst of all, my friend got BED BUGS. Talk about being embarrassed about booking that room. I would not recommend the hotel to anyone.
Too far from airport and ship port. Was not clean. Didn't book our shuttle when we requested it. Continental Breakfast was awful.
Customer service was horrible. I damaged by vehicle on the building because there were no signs warning me of a sharp turn. When I asked for help the staff was rude. When I asked for assistance from the manager over the phone he made excuses for his staff and refused to help with expenses to fix my vehicle.
It is a "nothing special hotel", next to a very busy road. Luckily my room was not noisy. Maybe the breakfast is a little boring after a few days. Also the wireless had problems in my room.
Nothing. I could not wait to check out. Nonsmoking room smelled like smoke. the room I was transferred to had the A.C. off. I had the front desk figure out the connection. the room did not cool off until after 3 A.M.
The staff were very pleasant & helpful. The hotel was in a prime location and we could use two beaches. One was within 5 - 10 minutes walking distance and the 'Fort Lauderdale Beach' was 5 - 10 minutes on the bus. There were a great choice of restaurants in the area too.
I liked the staff, the kinda retro vibe, low keyed. It was right next to the beach, just had to cross the A1A. Bar right there, free breakfast. Lauderdale by the Sea is more relaxed than Ft. Lauderdale and they didn't allow spring breakers in so there was never loud noise. I would highly recommend this hotel. It was all fine. It isn't luxury by any means so if you like super fancy, this isn't the place. Other than that, it was perfect.
Staff was was friendly, WIFI was very sporadic....and had to be outside to use it. So bring a long Ethernet cable as the port may not be in an ideal location (mine was hidden behind the TV stand) . Bar was closed (by the state of Florida.....not sure why.) Close to Beach, local stores and restaurants. Not fancy....no frills....but a good value. WIFI isn't strong ....must be outside of room (in patio area) to use. Even then it was sporadic. Parking was a little limited due to the rear parking lot losing about 10 spaces due to being flooded.
Nothing that we liked, my wife wanted to leave immediately and couldn't wait to leave, we travel the world, but this hotel is no three star, may be less than one.


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by Duncan Larkin, Published Jul. 6, 2011, Updated Jul. 6, 2011 at 8:44 AM UTC
Former world-record holder Zola Budd Pieterse will be competing in the games.
by , Published Oct. 8, 2009, Updated Oct. 8, 2009 at 1:29 PM UTC
Kick Off Marathon Weekend with Pep Rally at Niketown Are you ready for marathon weekend in Chicago? Niketown is bringing in the big guns
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Categories: Domination, Old Man
Tags: babe, euro, femdom, Humiliation, group, voyeur, handjob, european, cfnm, jerking, eurosex
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