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But the bad news is that the IT industry still has an unhappy fixation with hiring only experienced staff. Breaking in is as tough as ever. It's the problem of "How do I get my first job when companies insist that I have experience first?"
"If anything, I'd say the Catch 22 is worse than it was before the recession," says Clive South, of the IT recruitment consultants Software Personnel. "The recession blew a hole in the old 'jobs for life' ethos, so companies are even less prepared to risk taking on trainees, who will then move on to another employer."
Ironically, the current IT job boom makes the threat of defection even more real. "Everyone wants to hire the first job mover," says Mr South.
But a counsel of despair is not inevitable. According to this summer's figures published by the Association of Graduate Recruiters, "vacancies for graduates in industry are forecast to rise by 19.6 per cent" and the Association identifies IT as one of the main areas of recruitment difficulties, along with finance and engineering.
"A large proportion of our members reported difficulties in recruiting graduates into IT functions, the respective figures for 1995 and 1996 being 16.3 per cent and 21 per cent," reports the Association in its summer update.
So the trick is how to take advantage of those statistics to transform yourself from unemployed arts graduate to lucratively remunerated IT professional.
"Taking on your own training will undoubtedly help," says Mr South. It shows determination and basic ability, though it will still take a couple of years of hard work. "A course will get you going," he argues. "It won't take you half-way up Everest, but it will let you leave Base Camp behind."
That means enlisting on one of the hundreds of software training courses available, both commercial (expect to pay several hundred pounds for a two- to three-month intensive course), such as those from the training company Control Data, and from educational establishments such as the University of Westminster.
This was the route taken by Matthew Walker, who graduated in June 1994.
"I'd read American studies because it got me to the US for a year, but I didn't want to end up as a history teacher," he recalls. Instead he decided to sign on for a three-month government-funded scheme for unemployed graduates, and learnt a brace of PC applications in commercial use, such as Wordperfect, Paradox and the Sage accounting package.
"But it wasn't enough for me to get a career in IT," says Walker. So he moved to London, and paid his rent delivering kit to building sites while doing an evening class in the C programming language at the University of Westminster.
"It was very cheap, about pounds 40 for two terms," he says. But he found that his good marks did not automatically guarantee him a job in IT. "There were good jobs around, but everyone wanted computer science degrees," he recalls.
At Christmas, he applied to a major UK insurance company, and after four rounds of interviews and a barrage of tests, including psychometric and IT tests, he was in, employed as a Cobol and mainframe DB2 database programmer on pounds 14,500 a year.
His experience points to a surprising truth. Most graduates assume that the most useful IT skills are object-oriented languages, such as C++, or those associated with the new wave of distributed client-server computing, such as Unix, C, Novell and Microsoft Visual Basic, or even the latest hot language, Java. But there is still a real shortage of Cobol skills in the market and that demand can only rise, given the need to update millions of lines of Cobol code on mainframes to cope with the date change at the millennium: some estimate that Cobol programmers will increase by 50 per cent every six months until the year 2000.
Moreover, few computer science graduates will have paid much attention to such an old language as Cobol, however pervasive it is on mainframes. "For a non-computer science graduate, leaning Cobol or RPG is not such a bad way of breaking in to the IT industry," says South.
And once you're in, you can always retrain after a year or so and move into a more exciting area of IT
- More about:
- Computer Science
- Employment
- Programming
- Software

subset: commoncrawl


text:
Summarybar message goes here
Toll Free Number
Please enter the dates of your stay, number of rooms, and guests to see a list of available rooms.
Welcome to Best Western Plus Beach Resort!
Don't think that a beachfront vacation is expensive, because at our Fort Myers Beach hotel we offer our guests the best of beach living with competitive rates.
Indulge in your favorite water sports and take a stand up paddle board lesson near our Fort Myers Beach hotel. All rooms offer beachfront efficiencies, so it's simple to stroll outside and enjoy a day of sandcastle building, swimming or bronzing. Renovated in 2008, all rooms have private balconies that overlook the Gulf of Mexico.
Enjoy a relaxing beachside atmosphere while relaxing under our shaded tropical palm courtyard with shuffleboard and a beachside picnic area. Lounge at our beachside heated pool or spend the day on the beach with chair and umbrella rentals from Holiday Water Sports.
Fort Myers Beach hotels are close to the pier, restaurants, and shops are a short walk down the beach. The area has many attractions for the adventurist of all ages. Fishing, golfing, boat, and wave runner rentals are abundant, or enjoy a day of parasailing, exploring J Ding Darling State Park, Key West Express, or partake in a Big M Gaming Cruise. Offshore and inshore fishing is a popular choice for our Fort Myers Beach hotel guests. MLB Spring Training for the Boston Red Sox's and Minnesota Twins happens nearby, and is an exciting time for guests to stay with us. Southwest Florida truly has something for everyone.
Both the Coast Guard and Key West Express regularly bring service men and women or business travelers to our Fort Myers Beach hotel. If you're lucky enough to be in town on business, make sure you have plenty of time to take advantage of the beach right in your backyard. Nothing beats a relaxing stroll on the sands after a long day of work and meetings. Whether you're here for business or to enjoy the tropics, our friendly staff will ensure you're comfortable and relaxed.
Reserve a cool room at Best Western Plus Beach Resort, where the only thing we overlook is the Gulf of Mexico! Enjoy your stay.
Latest Reviews
We stayed here for 5 nights and really enjoyed it. We stayed there before several times in previous years and appreciate the view from the room which include a small kitchen area. Parking free of...READ FULL REVIEW
This was my husband and my second stay at this hotel and it still did not disappoint. This is a beautiful hotel with lush landscaping, right on the beach. The free breakfast was excellent. Coco...READ FULL REVIEW
Right on the beach and very short walk to all the restaurants and shops. Nice little area called time square that has entertainment on weekends. Few of the restaurants have oceanfront dining and...READ FULL REVIEW
Great place to stay! Workers are always cleaning the place to keep it in top shape! I would recommend any family to stay here and enjoy the area. Location is great to walk down to all the eating...READ FULL REVIEW
What a great place to stay! Location Location Location!!! Breakfast was the best of any hotel ones we have had. Very clean and the staff went above and beyond from the housekeeping to the front desk...READ FULL REVIEW


text:
Would this be a good sunny day activity?
Would this be a good hot day activity?
Would this be a good cold day activity?
Is this an outdoor attraction or activity?
Is this attraction suitable for all ages?
Is this attraction free to the public?
Would this be a good rainy day activity?
Does this activity require advanced planning, ticketing or reservations?
Is this activity accessible without advanced planning or reservations?
Is this attraction popular with tourists?
Thanks for helping!
We have visited here on several occasions after a long drive South from the UK. We often stop in Saarbrucken on the way to Austria. Although you can easily spend a day at Calypso...
read more
The place is absolutely worth a visit if you want to have a cozy relax "vacation" day at home ;) Lots of water fun, for big and small kids, outside pools with one salty pool and a Pool-bar!!! to recommend for all the parents out there... the cocktails hit you fast and furious...:)) All in all a great place, prices...
Dear Deelux1968,
thank you so much for the 5 star rating as well as for your kind words.
We are very happy that you enjoyed your stay and more speciafically the Poolbar.
We are looking forward to welcoming you soon again.
We have visited here on several occasions after a long drive South from the UK. We often stop in Saarbrucken on the way to Austria. Although you can easily spend a day at Calypso we tend to visit mainly for just a few hours. The indoor / outdoor pools are always great fun and the kids love it here; there...
Dear Captain_H_UK,
thank you for your great rating.
We like to hear you had a good time. Hope to see you soon again.
Your Calypso-Team
I always like to be there because of the nice site, good service, cleanness and many offers from massage to an exciting water park. But lovers of swimming can find a good solution, too. But the most reason for many people to go there is the huge sauna world. A nice place to relax and to enjoy "hot stone" sauna,...
Dear jueprivat,
thank you so much for your 4 Star rating.
We are glad that you enjoyed your stay and are looking forward to welcoming you soon again.
Best regards
Your Calypso-Team
Nice swimming pool with 4 slides and several pools both indoor and outdoor. Very well organized, friendly staff with clear directions on what is allowed and what is not, good value for money (took the family ticket for half a day).
Restaurant is ok but bit pricy.
Pool is attracting visitors from all over the region, so pretty crowded during...
Dear Chris100200,
thank you very much for 4 stars!
We are happy to hear that you enjoyed your stay.
We are looking forward to welcome you again very soon.
Kind regards
The Calypso-Team
Very nice facility. Very clean and modern. The outdoor heated pools and water slides are amazing in winter months when there is snow on the ground around. The changing rooms and facilities are very well designed especially for families and those with small children. The staff are very nice, friendly and helpful. There is definitely something for everyone here and...
Dear Maria,
thank you very much for your kind words.
We are glad to hear that you had a great experience.
Unfortunately you just gave us one star, maybe you meant five stars :)
Hope to see you again soon.
We had a blast going through all the slides, especially the AdrenaLoop. We left our wives in the bubbles, and went through all the toboggans like little boys over and over again.
Dear Jorik J,
thank you very much for your kind words.
We are glad to hear that you had a great experience.
Hope to see you soon again.
Kind regards,
your Calypso-Team
NATO Jr. wore himself out in this place. We arrived late, 1800h, on a hot Friday. Thought the place would be packed, but it looked like everyone was leaving, so we had most of the place to ourselves.
For adults, there's several inside & outside pools & a floaty river. Also a swim-up bar.
All charges go on your wristband,...
This place was the perfect idea for a weekend getaway. We stayed at a hotel nearby and got up early to hit the waterpark. Played like kids half the day on the water slides then headed upstairs to eat and relax in the spa area. The whole venue was clean and wonderfully decorated, especially the spa. The food was great...
One of the great things about living in Germany is that you can spend the day at a sauna and bath house. This is a very popular way to spend the day. The Calypso bath and sauna park is a great way for couples and families to enjoy the day. The sauna side is textile free (no clothing) but we...
This place is decent if you have nothing else to do and have a small child that needs to be entertained. It has a few small slides, a few pools, a few hot tubs and a bridge three stories in the air. One nice thing is the saltwater pool outdoors that is heated and very warm on a cool autumn...
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


text:
Domain hijacking
This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages)(Learn how and when to remove this template message)
Domain hijacking or domain theft (a cybercrime) is the act of changing the registration of a domain name without the permission of its original registrant, or by abuse of privileges on domain hosting and registrar software systems.
This can be devastating to the original domain name holder, not only financially as they may have derived commercial income from a website hosted at the domain or conducted business through that domain's e-mail accounts,[1] but also in terms of readership and/or audience for non-profit or artistic web addresses. Additionally, the hijacker can use the domain name to facilitate illegal activity such as phishing, where a website is replaced by an identical website that records private information such as log-in passwords, spam, or even distribution of malware.[2]
Domain hijacking can be done in several ways, generally by exploiting a vulnerability in the domain name registrar's system, through social engineering, or gaining unauthorized access to the domain owner's email account that is associated with the domain name registration.[3]
A frequent tactic used by domain hijackers is to use acquired personal information about the actual domain owner to impersonate them and persuade the domain registrar to modify the registration information and/or transfer the domain to another registrar, a form of identity theft. Once this has been done, the hijacker has full control of the domain and can use it or sell it to a third party.
Other methods include email vulnerability, vulnerability at the domain-registration level, keyloggers, and phishing sites.[4]
Responses to discovered hijackings vary; sometimes the registration information can be returned to its original state by the current registrar, but this may be more difficult if the domain name was transferred to another registrar, particularly if that registrar resides in another country. If the stolen domain name has been transferred to another registrar, the losing registrar may invoke ICANN's Registrar Transfer Dispute Resolution Policy to seek the return of the domain.[5]
In some cases the losing registar for the domain name is not able to regain control over the domain, and the domain name owner may need to pursue legal action to obtain the court ordered return of the domain.[6]
Although the legal status of domain hijacking was formerly thought to be unclear,[7] certain U.S. federal courts in particular have begun to accept causes of action seeking the return of stolen domain names.[8] Domain hijacking is analogous with theft, in that the original owner is deprived of the benefits of the domain, but theft traditionally relates to concrete goods such as jewelry and electronics, whereas domain name ownership is stored only in the digital state of the domain name registry, a network of computers. For this reason, court actions seeking the recovery of stolen domain names are most frequently filed in the location of the relevant domain registry.[9] In some cases, victims have pursued recovery of stolen domain names through ICANN's (Uniform Domain Name Dispute Resolution Policy (UDRP), but a number of UDRP panels have ruled that the policy is not appropriate for cases involving domain theft.[10][11][12][13]
Another method of cybercriminals doing "domain hijacking" is from the backend of hosting and registrar companies. Misusing their company systems to prevent the owner from being contacted by interested parties, for example by fraudulently entering whois-data, and even knowingly stopping or cancelling a customers payment for renewal, allowing the "stolen" domain to then be expired and auctioned via a domain-auctioning site. This is considered to be backend computer-misuse, which is within the scope of the U.S. Computer Fraud and Abuse Act and the UK cybercrime legislation.[14]
Although many persons have been involved in Domain Hijacking and cybercriminal "drop-catching", police have made arrests for these offenses in several jurisdictions.[15]
ICANN imposes a 60-day waiting period between a change in registration information and a transfer to another registrar. This is intended to make domain hijacking more difficult, since a transferred domain is much more difficult to reclaim, and it is more likely that the original registrant will discover the change in that period and alert the registrar. Extensible Provisioning Protocol is used for many TLD registries, and uses an authorization code issued exclusively to the domain registrant as a security measure to prevent unauthorized transfers.[16]
There are certain steps that a domain-name owner can take to reduce the exposure to domain name hijacking.[17] The following suggestions may prevent an unwanted domain transfer:
Use strong email passwords and enable two-factor authentication if available. Disable POP if your email provider is able to use a different protocol. Tick the setting "always use https" under email options. Frequently check the "unusual activity" flag if provided by your email service. Use a two-step (two-factor) authentication if available. Make sure to renew your domain registration in a timely manner—with timely payments and register them for at least five (5) years. Use a domain-name registrar that offers enhanced transfer protection, i.e., "domain locking" and even consider paying for registry locking. Makes sure your WHOIS information is up-to-date and really points to you and you only. If you have 2500 or more domain names consider buying your own registrar. Relief via the Inter-Registrar Dispute Process [18]
See also[edit]
External links[edit]
- Major Domain Hijacking Alert: Industry Pioneer Warren Weitzman Has Over a Dozen Domains Stolen From his Enom Account
- Anatomy of a Domain Hijacking
- Wall Street Journal: Web-Address Theft Is Everyday Event
- Office of Attorney General - State of New Jersey: First Known Conviction in U.S. of Domain Theft
- Quotes from Landmark 2011 Domain Name Theft Case: First U.S. Criminal Conviction
- Stop Domain Theft - Alerting Media, Lawmakers, Law Enforcement
- non-profit trade organization representing domain name investors, website developers and related companies.
- How to Recover a Stolen Domain Name
- Domain Name Security Checker Tool
- ^ Simon, Ruth. "Cybercriminals Are Misappropriating Businesses' Web Addresses As a Result, Customers Can't Find the Real Companies on the Web". The Wall Street Journal. The Wall Street Journal. Retrieved 12 September 2016.
- ^ Weslow, David. "Dealing with cybersquatting: the wisdom of thinking ahead". TBO: Trademarks & Brands Online. Retrieved 12 September 2016.
- ^ "CLBR Featured Segment: David Weslow on Domain Theft". Cyber Law Radio. Retrieved 12 September 2016.
- ^ http://aplegal.com/2014/12/31/slamming-door-domain-name-hijacking/
- ^ "Registrar Transfer Dispute Resolution Policy". ICANN. Retrieved 12 September 2016.
- ^ "Domain name theft: Knowing where to turn". TBO: Trademarks & Brands Online. Retrieved 12 September 2016.
- ^ Smith, Gerry. "When Hackers Steal A Web Address, Few Owners Ever Get It Back". The Huffington Post.
- ^ Berkens, Michael. "Wiley Rein Files Suit Over 14 Stolen Domain Names: 9 Are 3 Letter .com's". The Domains.
- ^ Allemann, Andrew. "Lawsuit filed to recover stolen three letter domain names". Domain Name Wire. Retrieved 13 September 2016.
- ^ "WIPO Arbitration and Mediation Center". Retrieved 12 September 2016.
- ^ "WIPO Arbitration and Mediation Center". WIPO: World Intellectual Property Organization.
- ^ "Mascot Media Circle, LLC dba OnlineMBA v. WhoIsGuard, Inc. / Ahmed Guettouche Case No. D2015-1209". WIPO: World Intellectual Property Organization. Retrieved 12 September 2016.
- ^ Forum: Arbitration, Mediation, International http://www.adrforum.com/domaindecisions/1674326.htm. Retrieved 12 September 2016. Missing or empty
- ^ https://www.snapnames.com/domainnewsresources/news/how_to_get_a_domain_that_is_already_taken
- ^ http://www.internetblog.org.uk/post/370/more-domain-theft-arrests-could-be-on-the-way/
- ^ Internet Corporation For Assigned Names and Numbers (15 July 2005). "DOMAIN NAME HIJACKING: INCIDENTS, THREATS, RISKS, AND REMEDIAL ACTIONS" (PDF). Retrieved 17 October 2014.
- ^ Cyger, Michael. "Help! My Domain Name Was Stolen (And 3 Ways to Recover It) – With David Weslow". Domain Sherpa. Retrieved 12 September 2016.
- ^ http://aplegal.com/2014/12/31/slamming-door-domain-name-hijacking/


text:
I can not believe that I have 3 weeks of Nutrisystem under my belt (pun intended!) already! It has been going pretty smooth. This week was a little hectic in terms of my schedule so I did hit some bumps in the road. Doctors appointments, a new college class and a 3 years old birthday party really threw me for a few loops.
What did I learn from my busy schedule and trying to stay on my diet?
I need to pack an emergency kit for my car. I need to have healthy snacks and Nutrisystem snacks/meals with me at all times. This way when I spend all day traveling from appointment to appointment, I don't just starve myself or turn to a quick fix like fast food. This week I did have a few "slip ups" but I have learned and have packed my emergency bag so hopefully I will be more prepared next time.
This week, I also got to customize and order my next month of food and I am excited this time around because now I know exactly what foods I like. This time when the box arrives I know it will be full of all my yummy favorites! Pizza, popcorn, cinnamon rolls and chocolate muffins!
So now for the important part…
Week #1 = -3 lbs
Week #2 = -2 lbs
Week #3 = -2 lbs
Grand Total = –7 lbs
I fought through my busy schedule with only a few minor slip ups and lost 2 more pounds!
Go me!
Now to check in with my Nutrisystem Buddies:
Each of my NS buddies are in a different stage of the program so if you want to see what it is truly like to take the Nutrisystem journey you may want to check out their blogs as well.
Brett @ Mama Loves Her Bargains
Xenia @ Thanks Mail Carrier
Heather S. @ Our Kids Mom
Heather @ Living on Love and Cents
Melissa @ Sippy Cup Mom
Want to join me on the Nutrisystem journey? Sign up and receive a special offer or call 1-888-853-4689!
Disclosure: Nutrisystem is providing me with food and program support free of charge in exchange for blogging about my experience as part of the Nutrisystem Nation Blogger Program. The opinions above are 100% my own. Of course, others experience may vary.


text:
The horror device of a small, at-first-cute child turning out to be anything but has been absolutely done to death. Popularised by Japanese horror (or "J-Horror" as it's commonly known), with the likes of Ringu and Ju-On: The Grudge, English speaking audiences are most used to it in the remakes of these original pieces of brilliant cinema.
What's refreshing to see, then, is a movie like Orphan, which takes that idea and puts a relatively fresh spin on it. This is achieved through the way in which the little girl, in this case a 9 year old Russian orphan, is slowly but surely unveiled as a lot worst than she looks. The film has an effective grasp on what makes a scary scene, and some fine performances. It's let done, however, when it gets to the last 20 minutes with the obligatory explanation/twist – why does that almost always happen with these kinds of movies?
The film follows a couple who have just recently lost a child through a still birth, and sometime later decide to adopt a child to join their family. They already have two children, a rebellious boy and an almost-deaf girl, and they decide to adopt a quiet, sensitive and extremely bright little girl, Esther, who was forced into adoption after her family was killed in a fire. At first everything seems to go well, but things start to go wrong when the mother (Vira Farmiga) starts to notice something isn't quite right with Esther.
Orphan is saved by director Jaume Collet-Serra (House of Wax remake) having the knowledge of the difference between a genuinely effective jump scare and creepy atmosphere, and just loud noises that evoke a natural human reaction. There's a difference, and sadly not many horror movies these days realize this. Orphan thankfully does. There is many-a-moment, much like in the similarly titled Spanish film, The Orphanage, that the scene will build up with tension as if something is going to pop out, but just when you think something's going to happen nothing comes of it. This could be very frustrating if done wrong (overly done, for example) but it's employed pretty damn well here.
For gore to take place, there has to be some reason for it. Some logical purpose within the film's story for someone's blood to end up on the outside through some horrible means. This is something Orphan thankfully realizes, too. This is without a doubt a bloody and gory film at times (a jarring pre-credit dream sequence comes to mind right away), but not in the fashion that Hostel or some of the lesser Saw movies (i.e. the endless sequels) are. There's justification for the copious amounts of blood that spills. And I don't think it's a spoiler that the majority of this horrible carnage comes from our deceptively loveable orphan, Esther.
The fact that Esther is the "villain" of the picture isn't really a spoiler, since anyone who's seen half a dozen modern American horror movies should be able to guess going just by the premise, or even poster which depicts a suspect little girl with ponytails. No, the devil (so to speak) is in how the events within the film play out, which a lot of the time is structured as Esther causing various problems for her newly adoptive parents.
With the very precise application of often spine chilling atmosphere, and the surprisingly great performances from Farmiga, Peter Sarsgaard and Isabelle Fuhrman (playing Esther), it's all the more disappointing to get to the film's climax to find one of the most ridiculous explanations to what's been going on for the past 90-plus minutes that I've seen in quite some time. Not to give too much away, but let's just say everything slots so conveniently into place with this one laughable and ludicrous explanation that it drags the film way down. In one swift move, the film went from a very, very good example of how this type of horror should be done, to simply an enjoyable chiller.
So even if the ending of the film weighs it down significantly, I still recommend Orphan to anyone who enjoys well done thrills and chills. It may employ one of the horror genre's most overused devices (the creepy little child), but it at least tries to do something unique and original with it. This is The Ring without the supernatural element, or The Omen without the religion.
The film is about 25 minutes too long, with the occasional lull in the narrative that could have been removed to remedy that. But overall Orphan can rest assured it's a more impressive example of mainstream horror than most that gets released nowadays.Powered by Sidelines


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Crown Vintage Tabitha Bootie
Sorry, this item is sold out!
Looks like you've got more shoe shopping to do - have fun!
Looks like you've got more shoe shopping to do - have fun!
Item # dsw12prod4970065
Step out in a casual leather Chelsea boot from Crown Vintage. The Tabitha is the perfect transitional bootie to rock any season!
- Leather upper
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By: mickey85470
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November 15, 2016
leather too stiff
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November 15, 2016
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November 10, 2016
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May 21-25, 2015
Purina Farms,
Grey Summit, MO
The specialty is now over and it was hugely successful. Congratulations to the entire committee and members for an extraordinary job on this event.
For information about the results please check here. (Please note that this takes you to Rau's website and a drop-down menu with various ways in which to search the results.)


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Timothy Johnson vs Alexander Volkov
UFC Fight Night 99 - Mousasi vs. Hall 2
Main Card Fights watch video >>
http://fightnetwork.com/ - Paul Shaughnessy (@PaulShag) and Cody Saftic (@CjSaftic) preview Timothy Johnson vs. Alexander Volkov ahead of their bout at UFC Fight Night Belfast this Saturday in Northe watch video >>
A heartfelt tribute at XFC Australia and action from Alexander Volkov and Alexander Shlemenko in highlights from Inside MMA. AXS TV is Your Home for MMA every Friday Night! Find AXS TV HERE: http:/ watch video >>
Alexander "Drago" Volkov vs Cheick "The French Sensation" Kongo
Bellator 139 - Kongo vs. Volkov
Kansas Star Arena, Mulvane, Kansas, United States
June 26, 2015 watch video >>
Tonight to behemoths step in the cage! Who wins? Jimmy Smith breaks down what to watch for. watch video >>
Zane Simon is once again joined by Victor Rodriguez and Eddie Mercado of http://www.bloodyelbow.com/ to talk about the Bellator 139 fight card headlined by Cheick Kongo vs. Alexander Volkov and inclu watch video >>
As he prepares for his fight vs Alexander Volkov, take a look back at the slick sub by Cheick Kongo that's very much a part of his foundation. watch video >>
On Friday, it's a Heavyweight scrap with Cheick Kongo facing Alexander Volkov live and free on Spike! Former Champ Pat Curran returns to the cage to take on Emmanuel Sanchez while striker Joe Schilli watch video >>
Alexander "Drago" Volkov sent a message to the Heavyweight division, after his devastating head kick win over Mighty Mo! Jimmy Smith Breaks down his remarkable win. Watch Volkov return to the cage watch video >>
http://fightnetwork.com/ - Fight Network previews Bellator 139 set for June 26, 2015 featuring Cheick Kongo vs. former heavyweight champion Alexander Volkov, season 8 lightweight tourney winner David watch video >>


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SEO Article Rewriting - 6 Articels needed
- Status Completed
- Budget $30 - $250 USD
- Total Bids 18
Project Description
We are a company that sells a software for marketing automation, now we are looking for a freelancer to help us to rewrite the text from a Buying Guide (published by ourselves) into a blog series.
The Guide consists of approximately 2700 words and will be rewritten into 6 blog posts.
Type of blog series: The blog series is about "The inbound marketing process", including the following topics; Drive traffic, Capture contacts, Nurture leads, Close sale, Sell more
Please note the text already exists today. The job consists of rewriting the text into a blog series.
Language: English, perfect grammar and tone of voice is important.
Special knowledge: It is important that you have real interest in marketing. We are looking for a long term relationship.
Every page shall be written with a SEO perspective, including:
- 100% Copyscape passed
- Right keyword density (1-3%)
- Proper meta description (max 150 chars)
- Page title (max 64 chars)
- Right headings (H1, H2…)
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A Diamond.... so sharp, not just
inspiration for art, beautiful and rare. For
diamonds, a constant stare.
A Rainbow....sung by artists, used by
cultures, a period of unresistable colours
together, one list.
A Diamond.....just a thing, created conflict
and clash between class.
A Rainbow.....exposes due to rain,
something most people despise, people
created lies.....
Theres always two sides to everything,
you see, dont take sides, make a smart
judgement that blame should not be
© Copyright 2017 Headphones Vocal Method. All rights reserved.
Status: Finished
Genre: Poetry
Poem / Poetry
Poem / Poetry
Poem / Poetry
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Serves 4-6
Place all ingredients in blender.
In a large stainless steel bowl, mix noodles, Thai vinaigrette, cucumbers, green papaya and bean sprouts. Toss well, then gently mix in cilantro and mint leaves. On 4 plates, divide shredded lettuce equally and top with tossed noodles. In stainless steel bowl, toss shrimp in remaining vinaigrette and place on top of noodles. Top with crispy shallots.
** These items found in Asian grocery stores
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I hope you are trying out the fertility of these
Lakeside Elf X Nut Ruffles seedlings. Are these seedlings OGB- ? If
there is fertility, that would be a good thing, as we have so few fertile
arilmedians. Pretty flower.
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Canadian weather radar network
The Canadian weather radar network consists of 31 weather radars spanning Canada's most populated regions. Their primary purpose is the early detection of precipitation, its motion and the threat it poses to life and property. Each has a range of 256 km (159 mi) in radius around the site to detect reflectivity, and a range of 128 km (80 mi) for detecting velocity patterns (Doppler effect).
Research in weather radars in Canada began at the end of the Second World War with "Project Stormy Weather".[1] After the war, J.S. Marshall continued at McGill University the work with the "Stormy Weather Group".[2] The Canadian network was thus gradually formed and by 1997, there were 19 weather radars of two kinds across the country: 18 five centimeter wavelength (C-Band) radars and 1 ten centimeter wavelength (S-Band) at McGill, all of the radars detected reflectivity with 3 sites equipped with Doppler capabilities (Carvel, King City and McGill).
Environment Canada received approval in 1998 to upgrade the network to Doppler standard and to add 12 more radars with the operational characteristics coming from King City weather radar station (CWKR), the research radar of Environment Canada.[3] However, McGill radar (at the J. S. Marshall Radar Observatory), while being part of the network, is owned by McGill University. It is a research as well as an operational radar and is modified independently. The Jimmy Lake and Lac Castor stations are owned and operated by the Department of Defense (DND), these are also part of the network.
- McGill radar (at the J. S. Marshall Radar Observatory):[4]
- 9 metre (30 feet) diameter antenna.
- Uses a klystron to produce a wavelength signal of 10 cm. (S-Band)
- Doppler since 1993 and dual polarization was added in 1999.
- King City weather radar station
- This research radar is essentially a WSR-98A (see below) upgraded with dual polarization capability in 2004.
- The rest of the network:[3]
- The upgraded radar have antennas from two manufacturers: Enterprise Electronics Corporation (EEC) and Raytheon.
- The new radar have antennas produced by Andrew Canada. With a diameter almost double the old ones; resolutions improved by the same amount.
- Use 5.6 cm wavelength emitting magnetrons. (C-Band)
- Process received reflectivity and Doppler data with Sigmet Radar Data Systems, now a part of Vaisala Oyj.
- Each radar in the network will thus be called a WSR-98E, WSR-98R or WSR-98A for Weather Surveillance Radar - 1998 (for the year of the start of the program) and the first letter of the manufacturer of the Pedestal/Antenna (Enterprise, Raytheon or Andrew).
- Antennas of 3.6 metres in diameter for the ungraded radars and 6.1 m for the new ones.
- Pulse length and pulse repetition frequency adjustable. Pulse length 0.8,1.6 and 2.0s. Pulse repetition frequency (PRF) 250 Hz and Dual PRF (Doppler Mode) 1190/1200 Hz.
Scanning strategy[edit]
Because the network is using C band radars, compromises had to be used (see Doppler dilemma) between maximum reflectivity range and maximum non ambiguous velocities. The actual scanning strategy (2006) is divided in two separate scans over 10 minutes:[3]
- Conventional cycle: 24 elevation angles scanned in 5 minutes to obtain a tri-dimensional view of the atmosphere within 256 km of the radar in reflectivity.
- Doppler cycle: 4 angles scanned in reflectivity and velocities, the first three in a range of 128 km and the last within 256 km. This cycle is used to locate possible small scale rotation and shear in the wind pattern as well as the large scale circulation. The velocity data also help to filter artifacts in the reflectivity such as ground echos.
The McGill radar is currently the only station that uses a S-band transmitter instead of a C-band transmitter to acquire reflectivities and velocities during each of its 24 elevation angles with the same 5 minute cycle time.[4]
Modernization project[edit]
Environment Canada received the funding from the Treasury Board in 2011 to undergo a major modernization project called 'WES Renewal' to upgrade to dual polarization all Canadian Radars in two separate five year plans. Complete network stabilization and systemic problems resolution will also be part of this major effort by Environment Canada. The first five years will concentrate on the upgrade of the ten 98A radars to dual polarization. McGill will be upgraded to a new antenna (will either remain S-Band or change to C-Band), but will be operated by Environment Canada in the near future (probably by 2016).[5]
List of radars[edit]
The first modernization process began in the fall of 1998 with the opening of Bethune radar and ended in 2004 with the one in Timmins.[6]
See also[edit]
- NEXRAD, the weather radar network in United States
- ^ Atlas, David. Radar in Meteorology. American Meteorological Society.
- ^ "Stormy Weather Group". McGill University. 2000. Retrieved 2006-06-15.
- ^ a b c Joe, Paul; Steve Lapczak (2002). "Evolution of the Canadian operational radar network" (PDF). Proceedings. 2nd European Conference on Radar in Meteorology and Hydrology (ERAD). Delft, The Netherlands. pp. 370–382. Retrieved 2011-09-19.
- ^ a b J. S. Marshall Radar Observatory (2010). "McGill S-band radar". McGill University. Retrieved 2011-09-19.
- ^ Government of Canada (January 25, 2012). "Weather Monitoring Infrastructure". Environnement Canada. Retrieved October 29, 2012.
- ^ "The National Radar Program". Environment Canada. 2004. Retrieved 2006-06-15.


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More Videos...
Duramax 2500 vs. Cummins 2500
My bros Dodge vs my friends Dmax. I have a 6.0 Ford. * We know there is a difference in years, power, and traction. We did this as just something fun to do in spare time. Quit bitching about whats wrong with it. It was never supposed to be the last word on which is better. What were you expecting?
Cummins vs duramax tug of war
Lifted duallys at the texas heatwave 2014
Duramax vs Cummins
Crew cab duallie Duramax vs. crew cab Cummins. both mid 12 seconds trucks.... very close at the end... Duramax was about a half truck length ahead.


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Lo and behold, there is a new team in control of its own destiny in the Atlantic Division. Hello NC State!
Now that the Wolfpack have pulled the upset on Florida State, can they run the table and get into the ACC championship? Heather and I weigh in on the hot topic of the day.
Heather says: Yes they can.
What happened in Raleigh on Saturday night shouldn't have come as a surprise.
The more puzzling performance was how poorly NC State played against Tennessee in the season opener, and how average the Wolfpack looked through the month of September. NC State entered this season capable of having a special year under coach Tom O'Brien -- a darkhorse candidate to play in Charlotte -- and thanks to Saturday's monumental upset, it still can.
NC State now controls its own destiny in the Atlantic Division. It owns the head-to-head tiebreaker over preseason favorite Florida State. All it has to do is win out. You better believe O'Brien is a good enough coach to get that done. The Pack has a bye this week to emotionally digest the upset and turn its focus to Maryland. Back-to-back road trips won't be easy, especially against rival North Carolina on Oct. 27. The Tar Heels look like the most complete team in the Coastal Division, and they're playing much better defensively. Plus, the added motivation of a five-game losing streak to their in-state rivals and having home field advantage will be intangibles that favor UNC. The biggest test for NC State will be at Clemson on Nov. 17. Clemson, though, is one play away from losing again. The Tigers' defense continues to struggle, and it's a weakness quarterback Mike Glennon will be able to exploit. Don't forget that NC State beat then-ranked No. 7 Clemson at home a year ago.
The six turnovers and 14 penalties in the loss at Miami were inexplicable, but they were also an anomaly. NC State learned a lot from that loss, and to come back from a second straight 16-point deficit -- this time against the No. 3-ranked team in the nation -- shows that NC State can beat anyone in the ACC.
Florida State might still be the best team in the ACC, but until proven otherwise, NC State is the team to beat right now.
Andrea says: Not so fast my friends!
Tom O'Brien pulled a page out of his Upset 101 Handbook against the Seminoles last Saturday night. He refers to that book about once a year, right folks? But here is the thing about NC State: The Wolfpack have been unable to beat both Florida State AND Clemson in the same season since 2002.
That stat is one O'Brien pointed to several times during ACC media day earlier this summer. If his team can figure out a way to pull the upset against Clemson next month, then it will be in great shape. But I am not buying just yet. First of all, FSU coach Jimbo Fisher called way too conservative a game. I am not taking anything away from the plays Mike Glennon made to win the game for the Wolfpack. I give him and his teammates major credit for the comeback win.
But as EJ Manuel told reporters Monday, he thought the Seminoles would throw it more on what had proven to be a very inconsistent secondary. You can all but guarantee that Clemson is not going to go all conservative against the Wolfpack. If Miami receiver Phillip Dorsett had nearly 200 yards receiving on that secondary, well you can pretty much bet DeAndre Hopkins and Sammy Watkins will have their way. Yes, Clemson is not great on defense. But the Tigers are better than Miami. NC State may not be able to win a shootout.
Secondly, NC State still has injury concerns on the offensive line. Its receivers have been inconsistent. All-American cornerback David Amerson is not having a great year. This team has got big improvements to make.
Are they capable? Yes. Heather is right when she says this team has talent and potential.
But we have only seen one good game against a bona fide FBS opponent this season. I am going to need more than that to truly believe the Wolfpack are championship material.


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Please View Larger
Thank you all for your encouragement and support. This photo was placed on the Art Featured page in February 2008. The response has been awesome. There have been hundreds of views of this photo and many people favoriting "The Overseer".
This image was taken in 2006 with a Canon 300D. The location is the Milwaukee County Zoo in Milwaukee, WI.
Postprocessing was done in Adobe Photoshop Elements 6 and Corel 12.
Thank you all very much!!!
Canon 300D
1/200th Sec
Canon 75-300mm Zoom
2209 views and 91 favoritings as of 1/12/11


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Illinois Railway Museum
Categories:ARTS & CULTUREHISTORY
The mission of the museum is to demonstrate the vital role railroads have played in the growth of the Chicago area as well as the United States through the preservation and operation of railroad and mass transit rolling stock and the display of related artifacts in a realistic setting. These exhibits provide an interactive, educational experience for visitors of all ages. We welcome all to our Museum and encourage you to join in our education, restoration and preservation efforts.
Location & Nearby Attractions
What's Nearby


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FA is a rare disease and about 500 patients with FA are alive in the U.S.A. The 3 main clinical features of FA are birth defects (missing thumb/radius;microphthalmia;cafe-au-lait spots etc.), progressive marrow failure and cancer suscepfibility [1]. In FA. the life span Is severely shortened [2]. The main cause of death is bone marrow failure with the associated complications of anemia, bleeding and infecfion. Another cause of death is cancer, particulariy acute myelogenous leukemia, but also solid tumors, particulariy squamous cell carcinomas [3].
|Zhang, Qing-Shuo; Benedetti, Eric; Deater, Matthew et al. (2015) Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling. Stem Cell Reports 4:90-102
|Zhang, Qing-Shuo; Marquez-Loza, Laura; Sheehan, Andrea M et al. (2014) Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model. Pediatr Blood Cancer 61:740-2
|Kim, Hyungjin; Dejsuphong, Donniphat; Adelmant, Guillaume et al. (2014) Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Mol Cell 54:107-18
|Park, Eunmi; Kim, Hyungjin; Kim, Jung Min et al. (2013) FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell 50:908-18
|Zhang, Qing-Shuo; Watanabe-Smith, Kevin; Schubert, Kathryn et al. (2013) Fancd2 and p21 function independently in maintaining the size of hematopoietic stem and progenitor cell pool in mice. Stem Cell Res 11:687-92
|Dao, Kim-Hien T; Rotelli, Michael D; Brown, Brieanna R et al. (2013) The PI3K/Akt1 pathway enhances steady-state levels of FANCL. Mol Biol Cell 24:2582-92
|Mistry, Helena; Hsieh, Grace; Buhrlage, Sara J et al. (2013) Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther 12:2651-62
|Park, Eunmi; Kim, Jung Min; Primack, Benjamin et al. (2013) Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Mol Cell Biol 33:4360-70
|Garbati, Michael R; Hays, Laura E; Keeble, Winifred et al. (2013) FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1* in macrophages. Blood 122:3197-205
|Anur, Praveen; Yates, Jane; Garbati, Michael R et al. (2012) p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes. Blood 119:1992-2002
Showing the most recent 10 out of 81 publications


text:
This Blueberry Cheesecake Dessert recipe is my husband's favorite with a light, moist cheesecake topped with blueberry pie filling and whipped cream.
Before I got married almost 20 years ago, my family, my husband's family and my friends gave me a box of recipes. I love that recipe box and still have all of the recipes. They are tried-and-true recipes that I know I will turn out. I love that the recipes are handwritten which gives them a more personal feel. While I realize that it is somewhat ironic for someone who shares recipes online to treasure handwritten recipes, it is what it is. I decided to share one of the recipes from my box called Blueberry Dessert.
Disclaimer: Please note that some of the links in this post are affiliate links. There is no additional cost to you, but I will earn a small commission if you purchase through those links. Thank you for your support!
Brian's grandmother gave this recipe to me because she knew it was one of his favorites. Both his grandma and his mom used to make this dessert for him. It is light, moist cheesecake topped with blueberry pie filling and whipped cream. Here is the recipe she gave me (with her name removed to preserve her privacy). I'm not sure where the recipe originated so if you have the source, please share it with me and I will add a link to this blog post.
*Update: A couple of readers have said the credit for this recipe goes to Philadelphia Cream Cheese although I have not been able to locate it on their website to add a link here.
The first step is to crush 12 double graham crackers. You can use a food processor or a zip top plastic bag and a rolling pin to do the crushing. Add melted butter and sugar to the graham cracker crumbs. Press into a 9×13 inch pan.
Next, cream 2 packages of softened cream cheese using a stand mixer. Then, add eggs, sugar, and vanilla. Pour the mixture over the crust and bake at 375 degrees for 20 or more minutes until done (top is dry to touch).
Allow the dessert to cool and top with canned blueberry pie filling and whipped cream.
Zack came home from school and asked about this dessert. He was very unsure about it and didn't think he would like it. I encourage him to taste it and he surprised at how good it was! I brought the Blueberry Cheesecake Dessert to my parent's house to share with everyone. My mom was busy feeding a bottle to my niece when dessert was served but she wasn't worried because she wanted a piece of my dessert and knew there would be some left because we didn't think the kids would eat it. Then, we overheard Zack telling all of his cousins that they had to take a piece of the Blueberry Cheesecake Dessert because it was soooo good! We quickly set aside a piece of the dessert for my mom so that she could enjoy it after feeding the baby!
- 12 double graham crackers
- ¼ cup melted butter
- ½ cup sugar
- (2) 8 oz packages cream cheese - softened
- 4 eggs, beaten
- 1 cup sugar
- 1 teaspoon vanilla
- 1 can blueberry pie filling
- 1 tub Cool Whip
- Crush double graham crackers.
- Add melted butter and sugar.
- Press into 9x13 inch pan.
- Cream together cream cheese.
- Add beaten eggs, sugar and vanilla.
- Pour over crust and bake at 375 degrees for 20 or more minutes until done (top is dry to touch).
- Cool and top with blueberry pie filling and Cool Whip.
Here are three more of my cheesecake recipes to try:


text:
Looking for Indian girl for Webcam Website.
This project received 1 bids from talented freelancers with an average bid price of $12 USD / hour.Get free quotes for a project like this
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Open minded girls for erotic webcam show (just to chat) for a famous website. Basic pay per 3 hour of work is 30$ and you have the opportunity to earn more if you wish so by doing private but we do take a percentage. Website is totally safe and renowned. We pay biweekly. PM for more info.
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MAB E-Book: Eating & Overweight Beginners
View Single Post
Senior Member
Max Brawn
Join Date: Feb 2011
Location: Kansas
Posts: 1,974
Training Exp: 5+ years
Training Type: Bodybuilding
Fav Exercise: Pullup/Bent Over Row
Fav Supp: Feeding the Brain
Reputation: 186560
Originally Posted by
It begins with the
personal Interview of the trainee
(in this case a hypothetical overweight or severely overweight individual).
This can be implemented in a variety of different ways where the questions asked have the point of soliciting answers that will more appropriately setup diet mechanics and training to the persons individual particulars. People are going to vary in age, structured body type (as not all overweight, or severely overweight individuals are put together the same), and individual particulars need to be considered.
Once these questions are answered, and dependent on the content of these answers, the person can be pointed to a basic template of diet and training routines, in which advance as the person progresses.
How the above is actually structured, depends on the audience you want to reach, and some educated assumptions inferred. What do I mean by educated assumptions? It can be clearly stated that the e-book assumes one is medically cleared and healthy, and has no known physical complications or disabilities (as these bring different sorts of approaches, dependent on the complication, injury, or disability).
If you want I can setup, the "Personal Interview" questionnaire, and post it here.
But the e-book, needs to have a rolling structured format, which clearly defined intentions, and targeted audience.
Best wishes,
Steve how is this coming along? Have we decided anything? I posted some thoughts and questions, I think are important.
Where are we on this? Some threads can get forgotten or lost, so I thought I would bring this back from the dead
Best wishes
After losing 40+ unwanted lbs:
At 152/154lbs:
At 162-168:
View Public Profile
Send a private message to Chillen
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text:
Independence Day in Israel
Israelis celebrated the 38th anniversary of their independence Wednesday without incident but mainly indoors. Unseasonably chilly weather discouraged the usual mass exodus to beaches and picnic grounds. Thousands of residents of the northern border town of Kiryat Shemona participated in Independence Day festivities. Local leaders said it was a gesture of defiance after a Katyusha… More ▸


text:
From Zach's pool hall's Catster Photos[ View profile page ]
|"Milo, doing what he loves"
Are you going on a fox hunt? Dude, you look so refined!
Your cat loves a clean toilet -- don't we all? Catster's singing Cat Lady, Sarah Donner, explains why.24
|"Milo, doing what he loves"
March 12th 2012 at 9:40 am
Copyright © I-5 Publishing, LLC. All rights reserved.


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Used Mclaren cars for sale in Alton
We currently have 0 used Mclaren cars available in Alton. With the widest range of private and trade Mclaren cars available in Alton, you have access to the biggest choice and the best prices.
Feel free to browse our selected vehicles, further refine your search, and find your perfect car.
Latest second hand Mclaren cars for sale in Alton
Sorry, it looks like we have no used Mclaren cars available in Alton
However we currently have: 3 Used Mclaren cars available in Hampshire on Auto Trader
Selection of the latest second hand Mclaren cars for sale in Hampshire
|Showing 1 - 3 results
Mclaren 675LT 3.8 V8 SSG 2dr
2015 (65 reg) Coupe
McLaren 675LT, Date of Registration 10/12/15, Only 1432 miles, Finished in Chicane Grey with Alcantara and Leather trim in black with green accent stitching to match brake calipers, …
Mclaren MP4-12C 2dr
2012 (12 reg) Coupe
Fully loaded with Carbon Fiber LHD. Recent Service and tyres. Full dealership facilities inc PX & Finance, Black Full leather interior, Left-hand drive, Pearlescent Volcano Red, …
Mclaren MP4-12C 2dr
2012 (12 reg) Coupe
We are very proud to offer this flagship Super Car For Sale., , This Wonderful car has a super high spec to include, P1 Carbon Paddles., Exterior - Pearl White Elite finish Paintwork, …


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Yet Another Act of Surrender from the Usual Suspects
Another sad act of surrender, compromise and collaboration on the part of certain orthodox Anglicans in the Episcopal Church. There are so many repugnant aspects of the document linked above it is difficult to know which ones to identify. Perhaps the worst is the core premise of the document, that those teachers and ordained leaders who promote homosexual behavior in the church are "brothers and sisters" with whom we are called to exercise tolerance and patience. Jesus despises such tolerance (Rev 2:20).
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Genetically Engineered Lymphocyte Therapy in Treating Patients With B-Cell Leukemia or Lymphoma That is Resistant or Refractory to Chemotherapy
This study has been completed.
Abramson Cancer Center of the University of Pennsylvania
Information provided by (Responsible Party):
Abramson Cancer Center of the University of Pennsylvania
ClinicalTrials.gov Identifier:
First received: December 9, 2009
Last updated: July 31, 2015
Last verified: July 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
Adoptive immunotherapy has been successful in treatment of cancer due the graft versus tumor effect, but effective treatment is typically associated with graft versus host disease (GVHD). Autologous T cell transfer for cancer immunotherapy is an alternative approach that offers cancer specific immunotherapy without GVHD. To break immunological tolerance to tumors, autologous T cells have been modified with tumor-specific T cell receptors (TCRs)1,2. Studies using this approach have demonstrated the potent expansion, trafficking and antitumor activity of the redirected autologous T cells, but the approach is limited by MHC restriction and therefore is challenging for broad clinical application3,4. An alternative approach is to modify T cells with a chimeric immunoreceptor (CIR) which mimics the signaling of the natural TCR when encountering tumor antigen. This creates a universal tumor specific TCR that can be used across patients with a common tumor antigen5. Despite advances in current treatments, most patients with B cell malignancies remain incurable. Most B cell lymphomas, mantle cell lymphomas, ALLs, CLLs, hairy cell leukemias, and a subset of acute myelogenous leukemias express the CD19 antigen6-8. Expression of CD19 is highly restricted to B cells, and is not detected on other normal tissues, including hematopoietic stem cells, thus making it a safe tumor antigen for the CIR approach9. Previous clinical approaches have utilized the CD3 or Fc receptor signaling chain for T cell activation10. Costimulation via 4-1BB signaling has been shown to improve antitumor activity in vitro, and therefore incorporation of this signaling chain in the CIR may improve function of the T-bodies in vivo11-13. Our hypothesis is that CD19:4-1BB:CD3 modified cells will demonstrate improved engraftment and function over CD19-CD3 modified cells in patients with B cell malignancies.
Hematopoietic/Lymphoid Cancer
Adult Acute Lymphoblastic Leukemia in Remission
B-cell Adult Acute Lymphoblastic Leukemia
B-cell Chronic Lymphocytic Leukemia
Prolymphocytic Leukemia
Recurrent Adult Diffuse Large Cell Lymphoma
Recurrent Grade 1 Follicular Lymphoma
Recurrent Grade 2 Follicular Lymphoma
Recurrent Grade 3 Follicular Lymphoma
Recurrent Mantle Cell Lymphoma
Refractory Chronic Lymphocytic Leukemia
Stage III Adult Diffuse Large Cell Lymphoma
Stage III Chronic Lymphocytic Leukemia
Stage III Grade 1 Follicular Lymphoma
Stage III Grade 2 Follicular Lymphoma
Stage III Grade 3 Follicular Lymphoma
Stage III Mantle Cell Lymphoma
Stage IV Adult Diffuse Large Cell Lymphoma
Stage IV Chronic Lymphocytic Leukemia
Stage IV Grade 1 Follicular Lymphoma
Stage IV Grade 2 Follicular Lymphoma
Stage IV Grade 3 Follicular Lymphoma
Stage IV Mantle Cell Lymphoma
Other: laboratory biomarker analysis
Genetic: polymerase chain reaction
Genetic: reverse transcriptase-polymerase chain reaction
Biological: anti-CD19-CAR retroviral vector-transduced autologous T cells
Biological: genetically engineered lymphocyte therapy
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Pilot Study of Redirected Autologous T-cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patient With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma
Resource links provided by NLM:
MedlinePlus related topics: Leukemia Lymphoma
Genetic and Rare Diseases Information Center resources: Lymphosarcoma Diffuse Large B-Cell Lymphoma Acute Lymphoblastic Leukemia Mantle Cell Lymphoma Chronic Lymphocytic Leukemia Leukemia, B-cell, Chronic Follicular Lymphoma Lymphoma, Large-cell B-cell LymphomaU.S. FDA Resources
Further study details as provided by Abramson Cancer Center of the University of Pennsylvania:
Primary Outcome Measures:
- Number of Adverse Events
|Study Start Date:
|July 2009
|Primary Completion Date:
|July 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm I
Patients receive CART-19 cells transduced with a lentiviral vector to express anti-CD19 scFv TCRζ:41BB administered on days 0, 1, 2 and 11 in the absence of disease progression or unacceptable toxicity
Other: laboratory biomarker analysis
Genetic: polymerase chain reaction
Other Name: PCRGenetic: reverse transcriptase-polymerase chain reaction
Other Name: RT-PCRBiological: anti-CD19-CAR retroviral vector-transduced autologous T cells
Given IVBiological: genetically engineered lymphocyte therapy
Detailed Description:
Primary objectives:
1. To evaluate the safety and feasibility of a single target dose of 5 times 10e9 total cells, acceptable range of 1.5 times 10e7 to 5 times 10e9 total cells comprised of autologous CART-19 cells that express the TCR zeta and 4-1 BB costimulatory domain.
Secondary objectives:
- Proof of mechanism: determine if 2nd generation CAR expressing 4-1BB costimulation domains have improved persistence in patients.
- Proof of concept: determine the effects of CART-19 on CD19 expression in vivo.
- Proof of bioactivity: Evaluate changes in systemic soluble immune factors in patients
- Proof of bioactivity: Evaluate impact of CART19 treatment on tumor burden
- Explore whether CART-19 cells retain anti-tumor activity in vivo.
- Determine if host immunity develops against CART-19.
- Characterize the relative subsets of CART-19 T cells (Tcm, Tem, and Treg).
- Describe survival and response rates
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Male and female subjects with CD19+ B cell malignancies in patients with no available curative treatment options (such as autologous or allogeneic SCT) who have limited prognosis (several months to < 2 year survival) with currently available therapies will be enrolled
- CD19+ leukemia or lymphoma
- ALL in CR2 or CR3 and not eligible for allogeneic SCT because of age, comorbid disease, or lack of available family member or unrelated donor
- Follicular lymphoma, previously identified as CD19+:
- At least 2 prior combination chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy
- Stage III-IV disease
- Less than 1 year between last chemotherapy and progression (i.e. most recent progression free interval < 1 year)
- Disease responding or stable after most recent therapy (chemotherapy, MoAb, etc)
- At least 2 prior chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy. Patients with high risk disease manifested by deletion chromosome 17p will be eligible if they fail to achieve a CR to initial therapy or progress within 2 years of 1 prior
- Less than 2 years between last chemotherapy and progression (i.e. most recent progression free interval < 2 years)
- Not eligible or appropriate for conventional allogeneic SCT
- Patients who achieve only a partial response to FCR as initial therapy will be eligible.
- Mantle cell lymphoma:
- Beyond 1st CR with relapsed or persistent disease and not eligible or appropriate for conventional allogeneic or autologous SCT
- Disease responding or stable after most recent therapy (chemotherapy, MoAb, etc...)
- Relapsed after prior autologous SCT
- B-cell prolymphocytic leukemia (PLL) with relapsed or residual disease after at least 1 prior therapy and not eligible for allogeneic SCT
- Diffuse large cell lymphoma, previously identified as CD19+:
- Residual disease after primary therapy and not eligible for autologous SCT
- Relapsed after prior autologous SCT
- Beyond 1st CR with relapsed or persistent disease and not eligible or appropriate of conventional allogeneic or autologous SCT
- Expected survival > 12 weeks
- Creatinine < 2.5 mg/dl
- ALT/AST < 3x normal
- Bilirubin < 2.0 mg/dl
- Any relapse after prior autologous SCT will make patient eligible regardless of other prior therapy
- Adequate venous access for apheresis, and no other contraindications for leukapheresis
- Voluntary informed consent is given
- Pregnant or lactating women
- The safety of this therapy on unborn children is not known
- Female study participants of reproductive potential must have a negative serum or urine pregnancy test performed within 48 hours before infusion
- Uncontrolled active infection
- Active hepatitis B or hepatitis C infection
- Concurrent use of systemic steroids. Recent or current use of inhaled steroids is not exclusionary
- Previously treatment with any gene therapy products
- Feasibility assessment during screening demonstrates < 30% transduction of target lymphocytes, or insufficient expansion (< 5-fold) in response to CD3/CD28 costimulation
- Any uncontrolled active medical disorder that would preclude participation as outlined
- HIV infection
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01029366
Please refer to this study by its ClinicalTrials.gov identifier: NCT01029366
|United States, Pennsylvania
|Abramson Cancer Center of The University of Pennsylvania
|Philadelphia, Pennsylvania, United States, 19104
Sponsors and Collaborators
Abramson Cancer Center of the University of Pennsylvania
|Principal Investigator:
|Noelle Frey, MD
|Abramson Cancer Center of the University of Pennsylvania
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on February 27, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222.
|Responsible Party:
|Abramson Cancer Center of the University of Pennsylvania
|ClinicalTrials.gov Identifier:
|NCT01029366 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|December 9, 2009
|Last Updated:
|July 31, 2015
Additional relevant MeSH terms:
Lymphoma, Follicular
Leukemia, Lymphocytic, Chronic, B-Cell
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid
Lymphoma, Non-Hodgkin
Lymphoma, Mantle-Cell
Lymphoma, Large B-Cell, Diffuse
Leukemia, Prolymphocytic
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, B-Cell
Lymphoma, B-Cell
ClinicalTrials.gov processed this record on February 27, 2017


text: Paul,Wow! Why is this still a seedling and not registered?ChristySkip & Christy HenslerTHE ROCK GARDENNewport, WAhttp://www.povn.com/rock/----- Original Message -----From: "J. Paul Hill" <email@example.com>> This seedling ( Queen in Calico x Sky Hooks ) has gotten me the bestresults as parent over any other tall bearded seedling of mine.....When it'sin the mood it will show horns......This stalk is from the neglected bedI've returned to. I was happy to see it doing well.....Paul Hill


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Hi, I'm William,
Welcome to my website.
I'm an entrepreneur and freelance web developer in Phoenix Arizona. I founded CornerstoneLibrary.com and the D3FY Development Group. I'm also one of the Meteor Captains in Phoenix. Whenever there's free time, I try to go rock climbing, camping, or practice desert survival.
Here you will find some stuff I write, and some pictures too. Feel free to browse my portfolio, read my blog, or send me a message.


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Garcinia Life Plus Review: IS it Scam or Magic Pill? Read Garcinia Life Plus all bad side effects, consumer complains, scam reports
The magic pill Garcinia Life Plus has flooded the internet offering the slim body you have always dreamed of without working out or dieting. Really? Is this possible? I myself have experimented with numerous supplements in hopes to find something to help me with my postpartum body but have failed to find something that works. I have little to no time to work out because of my daughter and it has become more and more difficult to drop the pounds which only increase. After several advertisements on Garcinia Life Plus I decided to give it a shot. Let's see the results:
The Official Garcinia Life Plus Website
The things that the official Garcinia Life Plus website promises are beyond impressive. It says that if you hate to or don't have time to exercise you will still lose weight! Because of the high consistency of HCA in the supplement hunger will be suppressed and fat will simply melt away all the while getting more energy. Could this really be the new magic pill to losing weight and if so, why aren't more people taking it? Unfortunately, I wasn't able to find any further substantial information about the supplement, ingredients, or possible side effects in the official website, which in itself was somewhat disquieting.
What is Garcinia Cambogia and where does it Come From?
Garcinia Cambogia, the main ingredient in Garcinia Life Plus is a pumpkin like fruit found in Southeast Asia and India. It was discovered that the natives have consumed it for centuries and have a number of uses for it including using it to reduce appetite while hunters are on long hunting trips. Although it does seem pretty reasonable that it could have similar effects on Westerners do bear in mind that after all, we not only eat a lot more junk food but we live relatively stagnant lives.
The reason Garcinia Cambogia has this effect is because it contains a lot of HCA which is Hydroxycitric Acid. HCA is extracted from the rind of the fruit and is known to increase serotonin levels and aid emotional eaters and prevents fat from being formed. These are all fantastic points but still not convincing enough.
The official Garcinia Life Plus has three easy to follow steps. Just take the pill 2-3 times a day, start burning fat, and transform your body. Sounds great but really??? Absolutely no effort? I cannot believe that this is possible and had to try it for myself.
My Experience with Garcinia Life Plus
I ordered a bottle of Garcinia Life Plus and dedicated two months to trying it. It cost me nearly $200 but I had to see if it really is that effective. I took it initially the first month without changing a thing. No added exercise or special diets, just the pills and what I've been doing so far. The first week was traumatizing to say the least, perhaps until my body got used to the effects of the supplement. I spent quite a bit of time in the bathroom and I had an upset stomach. They subsided slightly after the first week but I certainly took more bathroom breaks during those 2 months than I have in the last year.
The results from the first month were interesting but certainly not impressive. Perhaps because my metabolism got a kick in the butt I did manage to lose about 3-5 pounds but overall my body didn't really change much. Considering the price and the effect on my body and daily routine I wouldn't say it was really worth it. The second month I took the supplement I tried to find time at least 3 times a week to work out with one extensive workout and focused on eating healthier. The results were much better and nearly doubled but honestly, I think I would have been able to see these results even without the supplement if I had just done the workout and dieting alone. I am far from impressed.
How does Hydroxycitric Acid Work?
Garcinia Life Plus contains HCA which is extracted from the Garcinia Cambogia fruit rind. Generally the recommended amount of HCA in supplements is 50% for it to have an effect. Unfortunately I did not see anywhere on the official website what percent HCA Garcinia Life Plus has. Not only that but you cannot see anywhere the types of ingredients aside from HCA that are found in the supplement.
HCA is known to inhibit citrate lyase enzyme which is found in the body. It is an essential catalyst within the metabolic process of converting carbohydrates into fat, so basically stops fat from forming. In addition to this HCA is also known to suppress appetite and help reduce cravings. This in turn is great for emotional eaters because it helps manage the stress hormone which is what piles fat onto the belly. On paper this all looks feasible and a great addition for anyone looking to lose weight but its effectiveness has still not been researched enough to guarantee results.
They Claim Garcinia Life Plus is ALL NATURAL but it DOES have Side Effects!
One thing that really irked me in the official Garcinia Life Plus website is that they keep claiming that it is 100% natural, 100% effective, and has no side effects. Though the HCA extract is natural that doesn't necessarily mean that all ingredients are natural within the supplement to add to that you cannot guarantee 100% effectiveness with so little research and testing. Since supplements in general are not FDA approved or tested for safety and effectiveness generally there is no guarantee that what you read on websites such as these is true. With that said I did some research and found the following possible side effects, out of which I experienced nearly all.
Possible Side Effects from Garcinia Life Plus:
- Dizziness
- Dry Mouth
- Headache
- Upset Stomach
- Diarrhea
They aren't serious and do not put your life in danger however back in 2009 the FDA warned everyone taking supplements containing Garcinia Cambogia to stop because there were many people that were left with serious liver problems. To this day it still isn't known whether these problems were because of the Garcinia Cambogia or from other ingredients in the supplements themselves. Either way, considering this, make sure you do not take the supplement if you have liver or kidney problems just in case.
If you are taking medication do keep in mind that Garcinia Cambogia doesn't interact well with the following medications:
- Asthma & Allergy Medicines
- Diabetes Medicines
- Iron for Anemia
- Pain Medicines
- Prescriptions for Psychiatric Conditions
- Statins (drugs lowering cholesterol)
- Blood Thinners
Price and Payment Method
So, if you are still willing to try the supplement it's important to know the process of purchasing it. Initially you can try the supplement for 14 days. This of course is not near enough time to actually see if it works for you. All you pay is shipping & handling at $4.95. Your 14 day trial begins the day you order not the day you receive the supplement, which is a very important detail or else you will be charged the full price of the bottle. If you do decide to continue with the Garcinia Life Plus you will be enrolled in their membership program where you will receive a new bottle every month and will be charged $79.95 for it. Personally, I avoid these types of programs primarily because you feel pressured in continuing, communication with customer service is near impossible, and the moment you try to cancel they try to sell you something else or keep you in the program.
So is it the Magic Pill?
In all honesty, I don't think this supplement is for me. Garcinia Life Plus may be suitable for some people but with me it had pretty negative side effects that were far from comfortable and the price was outrageous. I don't really think it is necessarily a SCAM but Garcinia Life Plus is not what I am looking for because I think I can achieve that kind of weight loss by spending that money on a gym membership and healthy food.


text:
Schilling, Johnson cured many woes
How dominant were teammates Randy Johnson and Curt Schilling
in the 2001 fantasy baseball season?
Well, let's put the pair of Arizona aces to the ultimate
test: Mr. Johnson, Mr. Schilling meet Mr. Hampton, Mr. Neagle, Mr. Chacon and
four equally hideous-numbered Colorado relievers. These are your new teammates
for this test.
You will compete against that darling of fantasy baseball
known as the Marlins' pitching staff. Tell you what: We're also taking out Matt
Clement, who had a rocky season himself, and bringing in phenom Josh Beckett.
So that's Beckett, A.J. Burnett, Brad Penny, Ryan Dempster, Chuck Smith, Braden
Looper, Antonio Alfonseca, Armando Almanza and Juan Acevedo.
This is just a quick test using 2001 Roto statistics. (The
added Rockies combine for an ERA just below 5.00 and a WHIP right at 1.50, by
the way.)
The results:
Johnson, Schilling, et al: 87 wins, 4.02 ERA, 1.31 WHIP.
The Fabulous Fish: 54 wins, 4.11 ERA, 1.37 WHIP.
Saves? The Fish pulled it out, thanks to Alfonseca's 28,
but it's a small consolation.
The National League Rotisserie pitching season belonged
to Johnson, Schilling and an interesting combination of old and young starters
whereas the American League was pretty much a young man's game for starting
pitching in 2001.
Greg Maddux, John Burkett, Jon Lieber, Matt Morris (old
in terms of injuries, anyway), Kevin Brown and Kevin Appier were joined by Javier
Vazquez, Penny, Roy Oswalt, Wade Miller and Russ Ortiz.
Yes, in 2002, relief pitching will replace starting pitching
as the biggest head-scratcher. Will John Smoltz close in Atlanta? Will the Dodgers
sign a closer or turn it over to Matt Herges? Will Milwaukee go to Chad Fox?
Will Tom Gordon's arm hold together? Will Matt Mantei come back? Will Byung-Hyun
Kim pull a Rick Ankiel? Who will lead Pittsburgh with the usual team-high 15
saves? These are just a few of the closing questions, and a closing thought:
Thank goodness for Trevor Hoffman.
Previous question: These are good, but
I think we can beat 'em: More team names, please.
Try 'The Hitting News' or 'My Life as Tom House'
For the past four years I have had the tradition of naming
my fantasy club after an Oscar-nominated film. The list goes like this: Good
Will Bunting; Shakespeare in Glove; The Talented Mr. Rooney; and Lou Brockovich.
Could need some help next year!
Rob Rooney
Wildwood, Mo.
Prairie homer companions
I like baseball fiction and believe a team name should
be firmly grounded in that tradition. My team in the Naples Fantasy Baseball
League honors W.P. Kinsella's quirky Onamata, Iowa, and Garrison Keillor's
never-say-die Lake Wobegon town team, the Whippets. In the truest spirit of
fantasy, my guys all know "it's great to be young and an Onamata Whippet."
Jack Zerby
Naples, Fla.
The name's the thing
My team name is the Nannincompoops a pun on my
last name. In more than 10 years of fantasy league play, I'd never seen a
team lose 10 points in the final three days of the season and fall from second
place to fourth. Nannincompoops? Indeed.
Michael Nannini
Arlington, Va.
A place for everyone
My Scoresheet team is called the Malkin Tents. It was
a sad day when Mitch Meluskey was traded out of the NL, as it was my dream
to have a power-hitting catcher who also hit his teammates for power. Since
we play the winter version of Scoresheet as well (players of the past), I
also try to pick up historical troublemakers. My finest moment was trading
for the 1965 Curt Flood last year.
Robert Malkin
Not rural yawners
The name Urban Shockers combines baseball history (tragic
'27 Yankees' starter) with our league's metropolitan base (New York area).
Plus, it sounds good, suggesting a vitality and dynamism that our performance
has yet to match. Name: very good. Team: We're working on it.
Tom Kissane
New York
Next question: Is your league considering
any rules changes or additions this offseason? If so, what are they?
E-mail John Hunt at email@example.com
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