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Citation: (2005) Memories Are Made of This: Modeling the CaMKII Molecular Switch. PLoS Biol 3(4): e124. doi:10.1371/journal.pbio.0030124
Published: March 29, 2005
Copyright: © 2005 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We all know that our memories are stored somehow in our brains. But exactly how do we remember the way to our office or what our mother looks like or the date we got married? Scientists attribute our ability to store apparently infinite numbers of memories for decades to long-lasting changes in the electrical, structural, and biochemical properties of neurons. One cellular mechanism proposed to be involved in the storage of memories—long-term potentiation—involves alterations in the strength of messages passed from one neuron to another across structures known as synapses.
The initiation of long-term potentiation is caused by activation of n-methyl-d-aspartate receptors on the receiving neuron and a subsequent increase in the intracellular calcium concentration in a region of the neuron that is called the postsynaptic density. The increase in calcium, in turn, activates the calcium/calmodulin-dependent protein kinase II (CaMKII). This enzyme seems to play a critical role in long-term potentiation, and has been proposed as one of the leading candidates to act as the molecular switch that maintains stable synapse-specific cellular changes. To fulfill this role, CaMKII would need to have stable UP and DOWN positions, or states, much like a light switch.
Xiao-Jing Wang and colleagues now provide a new analysis that strengthens the argument that CaMKII is a molecular switch involved in the storage of long-term neural changes. The activity of the CaMKII holoenzyme (the complete enzyme consisting of both regulatory and catalytic subunits) is controlled by its autophosphorylation state—the enzyme is able to add phosphate groups to specific amino acids within itself. Previous modeling studies have shown that the interplay between the autocatalytic addition of phosphate groups to CaMKII and the removal of phosphate groups by protein phosphatase-1 (PP1) enzymes produces two stable states of the CaMKII enzyme at basal free calcium levels. The DOWN state is unphosphorylated; the UP state is highly phosphorylated. When there is a transient high input of calcium, as happens when long-term potentiation is induced, the CaMKII enzyme flips from a DOWN state to a persistent UP state.
The questions that Wang and colleagues have now asked are what factors affect the stability of the state of this switch, and how many CaMKII holoenzymes are needed to construct a switch that could last a lifetime. These questions are important because a switch that could be spontaneously reset by small, random fluctuations of the conditions within the postsynaptic density would not be useful in maintaining stable long-term changes. The researchers have used a mathematical probabilistic modeling technique known as Monte Carlo simulation, together with the known biochemical and thermodynamic characteristics of CaMKII and PP1, to test how random fluctuations in the chemical reactions involved in the CaMKII/PP1 system change the state of the switch.
They report that switch state stability requires a balance between the phosphorylation and dephosphorylation rates of CaMKII, and that the turnover rate of the kinase—the replacement of old molecules with new ones—critically affects switch stability. However, their main finding is that the lifetime of states of the switch increases exponentially with the number of CaMKII holoenzymes that are present. This finding is important because experimental work by other researchers has estimated that there are about 30 CaMKII holoenzymes present in a typical postsynaptic density, and until Wang's team did their modeling it was unclear whether this number of holoenzymes could build a switch stable enough to last a lifetime. In fact, Wang and co-workers estimate that a switch containing as few as 15 holoenzymes can remain activated for longer than a human lifetime. Thus, the researchers conclude, CaMKII switches may indeed play a critical role in preserving our precious memories throughout our lives.


text: do you keep fish as pets and go sport fishing also? Some people argue that sport fishing is cruel, others that it is okay. I used to go sport fishing when I was younger, not sure if I am right or not but I feel different about it now. Generally it seems people assert that using fish to cycle tanks if you know they will die is wrong or not taking care of fish is wrong, so is sport fishing wrong? I mean even if you are catch and releasing the bait fish are going to die. If you have a tank full of small fish and then when you go sport fishing with minnows or some bait that resembles your pet fish, does it make you feel sorry for the fish you catch or use as bait? I am not trying to assert a view either way, but I am curious to know what other peeps think about it.

subset: commoncrawl


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This is the January 30, 2013 news archive. View today's Wizards rumors and news.
Washington Wizards
Washington Wizards News and Rumors
Last Thing: Cartier Martin reveals his softer side
washingtonpost.com Updated Jan 30, 2013
It's been a while since I've done Last Thing, so I caught up with Cartier Martin on Monday night for a quick round. The Wizards forward talked about his funniest teammate and revealed his soft spot for his son. … Continue reading →Share Tweet
Ted Leonsis on Comcast SportsNet and Monumental Networkwashingtonpost.com Jan 30, 2013The two biggest sports business stories in this town over the next few years will be the Nats' relationship with MASN, and the Caps' and Wizards' relationship with Comcast SportsNet. That latter regional sports network - previously Home Team SportShare Tweet
Holiday Leads 76ers Past WizardsJan 30Jrue Holiday scores 21 points in 76ers' 92-84 win over Wizards.


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|Property type
|Minimum Stay
|2 - 5 nights
Drift into vacation bliss at Moondrifter 604! In a sea of cramped condos, Moondrifter stands apart, offering ample space for families even when their budget is small. This beachfront condo is ideally-located by the Super Clubs and is minutes from area attractions.
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After a day of playing in paradise, make yourself at home in this comfortable condo that sleeps up to six. The master bedroom and 2nd bedroom features a Queen size bed. The spacious living room complete with a queen sleeper sofa overlooks the waves. The fully-equipped kitchen is perfect for preparing budget-friendly meals. Best of all, your private beachfront balcony affords stunning, angled gulf views!
Enjoy peace of mind knowing that when you book Moondrifter 604 by Royal American Beach Getaways, you get 24-hour customer service plus a housekeeping and maintenance staff on call. After planning your vacation all year, the last thing you want are unwanted surprises to deal with when you're miles from home and your condo's owner is hundreds of miles away! Don't just book a room—upgrade to a getaway with Royal American Beach Getaways.
BONUS: Enjoy your first round of drinks on us—up to a $75 value! One drink voucher issued per person for travel between March and October. Drink voucher is good for one FREE 16 ounce signature drink in a souvenir cup at Spinnaker Beach Club for adults 21 and older or one FREE soda or iced tea for guests under 21. Additional restrictions may apply.
When we arrived our condo was a absolute mess. Rachel, on the desk that evening got a crew in and it was cleaned up beautifully. We really enjoyed our stay and all staff we met were really nice. Thank you for taking care of us. The property was well maintained and the pool was very nice also. we would recommend this property.


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W. D. Gann said Knowledge plus Time and Study equals consistent Profits.
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For those of you who actively trade (or desire to learn how to trade) the financial and futures markets, there are a lot of other things outside the markets you should be following. But, I guess my bigger message is for those of you that aren't in the futures markets, whether you trade them or not, the futures markets have a significant impact on what happens in the other financial markets, including forex, currencies, options and stocks. That's why you should soak up every piece of good trading knowledge like a sponge in a quest to clearly see the bigger picture. Click-here for a free ezine service to trading knowledge. Get started learning in the comfort of your home, on your schedule, at no cost today. click-here NOW to take advantage of this traders ezine offer!
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Here are some but far from all of the subjects covered in this Gann Trading Course: Did W D Gann use Astrology in his Trading? Square Chart Definition and Usage; Squaring Price and Time; Geometric Angles; Angle Concepts; Gaps on Charts; What Causes Chart Gaps; The Gann Square of Nine, plus more about Squaring Price and Time and other powerful Gann methodologies...
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"Matches are not taken seriously…and there is rampant, uncontrolled hobnobbing between players and bookmakers', a report into the 'grey findings' of the Delhi Police special cell into the recent spot-fixing scandal will read according to highly-placed sources.
The said report, which outgoing Delhi Police Commissioner Neeraj Kumar first mentioned in an interview to HT on Wednesday, is being given final touches and will be submitted before the month-end.
Though the top cop refused to comment on its contents, sources claimed it aimed at 'sensitising the state' about lack of 'adequate administrative control' on the tournament.
"Not just players participating in the Indian Premier League (IPL), but even the franchise owners don't take the matches being played seriously," said an officer who has contributed to the report.
"Apart from the use of female escorts, players are lured by bookmakers — who play a major role in the entire tournament — into activities which infringe conditions of the contract which they sign."
The report will have the tone and tenor of a report submitted by the police commissioner on lotteries during his tenure as deputy commissioner of the crime branch in the year 1991-92.
"It was on the basis of the report that lotteries were banned throughout the country. This time, his report will just argue for more administrative control over the IPL," said another officer.
Meanwhile, police sources said their investigations include having subjected players participating in the tournament to lie detector tests, which, however, came out negative.
The commissioner refused to divulge any details about their identities but sources said these included both Indian and international players whose names had cropped up during the interrogation of arrested bookies and players.
"We will file a detailed report to the government about our findings soon. Investigations have revealed many facts which need to be stated at the earliest," was all that the commissioner was willing to reveal.


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Portola Packaging Inc., PST to Market Shelf-Life Increasing Packaging Technology
October 30, 2008 | Contact Author | By: Rachel Chapman
- Article
- Keywords/Abstract
Portola Packaging Inc. and Plastic Solutions of Texas Inc. (PST) announced a joint agreement to market technology, closures and bottles that extend the shelf life of oxygen-sensitive products. According to the companies, the U.S. Food and Drug Administration approved and patent-pending technology that retards the growth of bacteria and helps retain the quality of a product for a longer period of time. The system can be implemented with simple adaptations to conservatively extend the sell by date by 5 to 10 days or more. Considering U.S. dairies dispose of over $1 billion per year in expired fresh milk, the savings implications could be significant, said the companies.
Supplied By
Z-Cote LSA
Z-COTE LSA provides broad-spectrum protection from long wave UVA rays and medium wave UVB rays by physically scattering, reflecting and absorbing solar radiation.
- Zinc Oxide
- Triethoxycaprylylsilane
- UVA, UVB Sunscreen
- UVA Protection
- UVB Protection
Supplied By


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Halcyon Condominiums
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Travel Blogs from Bangalore
A journey through time, remembrance of glory
... life, instead it became life and living of people here. We saw many the temples for past two days but the architecture used here is quite different and it looks modern. There is a fort behind and the view from fort was awesome. Blue sky, white sailing clouds, wavy hills, green landscape, splash of yellow from sunflower fields in between and the jewels of the crown are the centuries old Aihole temples.
It was the time to depart and head back to Bangalore, the ...
TMCs and Indian Visas
... As soon as our meetings concluded for the day, we walked around the nearby streets to look for souvenirs. The shops were overflowing with wooden carvings and creative toys and as most places seem to be in India, they were extremely colorful. After a short stint of meandering, we left to meet up with Akansha, one of Ana's friends from school and traveling. Akansha took us to an amazing bar called Church Street Social. We sat outside and ...
In the Begining...
... prying eyes. A big yellow lab named Bruno anxiously awaits my morning pets and sits in the sunshine beckoning me to join. The landlady is nice enough, jiggles her head like one of those toys that wobbles in the sunshine and waves at me when I leave. I have no hot water yet. Yes, cold showers from a bucket because the shower seems a bit much with a constant stream of chilly morning water jettisoning on me nonstop. Notwithstanding the lack of hot water, i've ...
Saved by technology ;)
... we will see! We also discussed the Annual Day, the four schools that run within the Parikrma bracket are going to be doing a performance for the Annual Day. We have to represent Courage and Fear, the colours that represent them have already been chosen, but we have been given the task of choosing what songs represent both courage and fear... All ideas welcome!
For the first time since my time ...
Bangalore and Mysore
Day 24
I woke up at 6 AM. The sleep was not great, but I definitely felt a little recovered after being so tired yesterday. The man sleeping next to me was actually pretty nice and let me use his cell phone to call Bob Barstadt, who worked with my father in Japan. I tried explaining to him this is not normal to sleep in the same bed as another man and say that you are straight and that I was very uncomfortable last night. ...


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For Immediate Release
June 23, 2013
Reno, Nev.-Tucson's Mike Wilson terrorized the Aces Sunday afternoon, as Reno suffered an 8-2 loss to the Padres at Aces Ballpark.
Wilson drove in six runs in the game, including a two-run home run in the first and a three-run shot in the seventh. His sixth double of the season in the fifth also drove in a run. The slugger went 3-for-5 with a pair of runs scored.
The Aces struggled offensively, posting just two runs on seven hits. An RBI double off the bat of Ed Easley and an RBI single by Alfredo Marted plated Reno's only runs.
Chris Owings' hot streak continued, as he recorded his 6th-straight and team-best 42nd multi-hit game. He went 2-for-4 in the game, with two doubles.
RHP Garrett Mock suffered his fourth loss of the season, giving up four runs on six hits through 4.2 innings. He walked four and struck out four. RHP Brett Lorin was the lone Reno pitcher to not give up a run, throwing a perfect ninth frame.
The series continues on Monday night at Aces Ballpark. LHP Tyler Skaggs (5-5, 4.60 ERA) will get the nod for Reno, while the Padres will counter with RHP Sean O'Sullivan (6-4, 3.95 ERA). First pitch is set for7:05 p.m. for another Margarita Monday presented by Alice @ 96.5, featuring half-price margaritas.
Tickets are on sale for tomorrow's game, and all Aces home games, at RenoAces.com, by calling (775) 334-7000 or by visiting the Aces Ballpark Ticket Office.
Today on MiLB.com
Top Stories on MiLB.com
- Torres keeps Baby Bombers in the spotlight
- Yanks' Judge homers off scoreboard in spring bow
- Toolshed: Sisco next in line for Orioles
- Braves taking flier on former NFLer Commings
- Phillies' Cozens opens spring with long ball
- Farm system rankings: Position players (10-1)
- Rays prospect Adames joins MiLB podcast
- Rebrand roundup: New looks abound in '17


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Month: July 2012
Lucy Knisley's "Standard Cat Formations" Comcis Are as Funny as They Are Accurate
How many of these does your cat perform? Airplane Ears? Observant Spiral? The Quad Mitten Defense?
Can My Cat Get Sunburned?
I'd heard about cats getting sunburned, but I thought it was all hype until I met a guy at my show who told me about his parents' sun-sensitive cat. This particular kitty lives in a hot and sunny portion of the country, so they administer special pet-safe sunblock on their cat's nose and ears …
Pete Plumley's Cat Trees Are Functional Works of Art
The former designer for "Pee-wee's Playhouse" makes items that are part sculpture, part furniture.
Guess What? It's Always Independence Day for Cats
In honor of Independence Day, I thought I'd talk about a few of the most independent things I know of: my cats.
The Infinite Cat Project: Cats Looking at Cats Looking at Cats Looking at Cats Looking at …
A never-ending stream of cats watching cats? Yeah, we'll look at that. Actually, our cat should look at that.
HooknLoop's Feline Wall Art Has Us Hooked
The Israeli design firm's wood panels of animals are perfect for the kids' room -- not to mention the dining room.
Happy Fourth of July! Here Are the 8 Most Patriotic Kitties on Shutterstock
We make fun of the patriotic cats on the most popular stock photo site. What's more American than that?
4 Cat Toys You Can Make from a Toilet Paper Roll
Believe us, your cat won't mind that you've turned a toiletry into a toy. Your cat won't even know, actually.
iPad Games for Cats: It's a Thing
How do you think cutting-edge cats unwind after a long day of sleeping? That's right: cat gaming.
The Robin and the Cats: An Unlikely Friendship
In the strangest pairing of the year, a small robin gets to be fast friends with a Michigan family's cats.


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The process of buying a new Honda car or truck can seem overwhelming if you don't know where to begin. Edmunds.com can get you started on the right track with a convenient directory of Honda car dealerships in and around Keizer, Oregon. Compare online price quotes on the new or used car, truck, SUV, minivan, or wagon of your choice to locate the best deals. Edmunds.com makes it easy to find trusted Honda car dealers in Keizer, saving car buyers time and money on what will be an important purchase.
Non Display Review Name "We had a truly wonderful experience. Pedro made it all worthwhile. We highly recommend him. Everything was positive! Truly please with our purchase! H"... Read more Review by: SalemBuyer47
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do you have the picture of 1814-5
i love to see the different siblings of a cross
it's addictive
--- In firstname.lastname@example.com, Autmirislvr@... wrote:
> In a message dated 11/17/2006 12:37:25 P.M. Central Standard
> tasquierloic@... writes:
> <<Both pol parents of each parent is Hindenburg, isn't it?>>
> Expanded parentage on 1814-3Re is (Earl of Essex x Hot Streak) X (
> Reflection x Hindenburg).
> The 2006 crosses does include Hindenburg X 1814-5. Cross # 2138.
This pollen
> parent in the peach sibling that you can see bits of in both
pictures and
> has not rebloomed. Only 22 seed. I really like some of the
variegatas that
> came from this cross, 1814. In fact, I like most of it's
siblings. There is
> also another red that is smoother, but doesn't rebloom. So far.
> always has to be qualified with a cross this new.
> ________________________________________________________
> Betty W. in South-central KY Zone 6 ---
> Bridge In Time Iris Garden@website:
> Where the seeds are in the pots once again!
> _www.thegardensite.com/irises/bridgeintime/_
> (http://www.thegardensite.com/irises/bridgeintime/)
> _Reblooming Iris - Home Page_ (http://www.rebloomingiris.com/)
> _iris-photos archives_ (http://www.hort.net/lists/iris-photos/)
> _iris-talk archives_ (http://www.hort.net/lists/iris-talk/)
> _AIS: American Iris Society website_ (http://www.irises.org/)
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Festival Phobia
February 02, 2013
Can we not embrace a possibility for the happy marriage between the holidays of the host nation and festivals of our home nation?
I get very nervous when an Indian festival falls on a weekday. Most of them have an elaborate menu with specific offerings and a lengthy recital of prayers which is almost impossible to cram in the hectic weekday schedule. If our measure of culture is in the frequency of festivals we celebrate, I'm going to fail miserably.
Pongal is the harvest festival that pays respect to the sun god and cows, both of which nourish our lives immeasurably. This year it fell in the middle of the week. So we burped on the savory pongal, filled our memories with sweet pongal and looked out of the window in vain at the snow filled emptiness. How do we thank the sun god if he fails to make an appearance?
But if the idea is to be thankful for the bounty that fills our homes and stomach, then would celebrating Thanksgiving appease our Gods? While I am not in favor of a big bird slow roasting in my oven, can we not make our own holiday menu? While it is important for my kids to understand the significance of Indian festivals, shouldn't they also learn to respect the holidays of the country they were born in? Does celebrating Thanksgiving make us more American? Can we not embrace a possibility for a happy marriage between the holidays of the host nation and festivals of our home nation?
Halloween is a ghostly all soul's day involving scary costumes and candy overload. It is the day when the entire nation decides to participate in a very elaborate fancy dress competition. Holi, on the other hand is a celebration of colors. Nothing can be as merry as a gang of friends chasing each other with a handful of colors and getting high over bhang. If Halloween sounds silly to our immigrant minds, take a look at our smeared faces. How can we truly claim ourselves to be globalized if we refuse to look outside the window and join in on the ceremonies?
Festivals are a celebration, a celebration of family and food. It doesn't matter which ones we celebrate as long as we send our children a consistent message - learn to appreciate the diversity while reveling in your uniqueness. Instead of clinging on to your nationality to give you an identity, embrace the world with joy. Growing up as an Indian on American soil need not be about making a choice to be either Indian or American. We can lead a hyphenated life where we learn to give thanks to the sun god with equal sincerity as we learn to give thanks over a roast turkey. What's on the table is not half as important as those around it.
So this year instead of merely crossing off the festivals that we celebrate, there is going to be more thought on the reasons behind the celebration. If the journey is more important than the destination, it's better to partake in the festivities rather than make excuses for skipping them.


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On This Page
Social Work
At Gillette Children's Specialty Healthcare, our social workers specialize in helping families through the psychological and social effects of managing their health care needs. We help patients and families adjust to new diagnoses or injuries, coordinate their care, cope with life and health transitions, and locate community resources.
All of our social workers are licensed by the Minnesota Board of Social Work, and many are clinically licensed as well. Our goal is to promote collaboration among patients, families and health care providers. In addition, we help you find resources related to social services, financial assistance programs, personal care assistance, therapy services and education.
Why Choose Gillette?
- Our social workers understand the unique needs of people who have disabilities and complex conditions.
- We believe that preparation and support can reduce stress and promote healing.
- We can help coordinate your care and community needs.
- Our specialists collaborate to provide comprehensive care.
Services We Provide
Our social workers provide emotional support and practical guidance for people who have disabilities that began in childhood. We help patients and families navigate the often complex world of health care and community resources.
Our services include:
- Assessment of psychosocial needs
- Assistance with practical needs, such as obtaining medical equipment, temporary lodging or overnight accommodations in Gillette's Ronald McDonald Family Room® (inpatients only)
- Counseling about issues of grief, loss and transition
- Crisis intervention, including addressing issues of family violence and abuse
- Education and assistance related to questions about guardianship
- Information and referrals to hospital and community resources (e.g. financial assistance, county services, information on guardianship, etc.)
- Short-term counseling to assist with emotional and psychological distress related to health care
- Support in preparing for discharge following a hospital stay
- Therapy (including play therapy) related to health conditions for children, adolescents and parents or caregivers
In addition, we help patients and their families prepare for the transition to adulthood, adult-focused services and care at Gillette Lifetime Specialty Healthcare.
For more information about the tests and treatments we offer at Gillette, search Conditions and Care.
Locations of Service
763-496-6000 or 888-218-0642 (toll free)Learn More »
952-936-0977 or 800-277-1250 (toll free)Learn More »
651-291-2848 or 800-719-4040 (toll-free)Learn More »
651-636-9443Learn More »
218-728-6160 or 800-903-7111 (toll free)Learn More »
Services vary by location. For all locations, visit Directions and Locations.
Why Gillette?
Because all children deserve a lifetime of amazing health care.Why Gillette »


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Freud Moka Stovetop Espresso Maker Oak
Product Code: FD0028
An inspired take on the traditional stovetop espresso makers the Freud Moka espresso maker is both stylish and easy to use.
Simply add espresso-ground coffee to the filter basket and then cold water to the bottom compartment. Join both parts together and place on your stove to heat. As the water boils it is forced under super heated pressure through the ground coffee to create the perfect espresso shot (4 servings per boiling).
Unlike most other Italian models the steam valve is aligned with the spout so that your hand is always away from escaping steam when pouring. And as always the Freud spout is drip free.
Volume 250ml
About The Brand
Freud was originally founded in London in 1986 by founder David Freud. Inspired by the coffee houses of Vienna, the brand started as a design room and bar in Shaftesbury Avenue in London. Now famed for its stylish cafe bars and elegant collection of teaware and sophisticated drinkware, Freud can be found in some fo the world's most prestigious restaurants and bars.
Why shop with Houseology
Houseology is not only the UK's premier online interior design store - it is an emporium of design ideas, advice & inspiration and a platform of tools & technology designed to make your interior design decisions and calculations easy.


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Rates in SGD (taxes & fees included), shown as:
Nightly Average
S$249 Avg. price/night
Qi Lu
No.103, Di An Men West Street, Back Lakes (Hou Hai), Beijing CN, China
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Qi Lu Hotel Reviews
Based on reviews from across the web.
Qi Lu Hotel Details
Check-in: 1600
Check-out: 1100
This hotel is located by the Ping'an Avenue, Beihai Park, Houhai Lake and HouhaiBar Street, Palace of Prince Gong, Coal Mountain Park are within walking distance to hotel. Forbiddedn City is about 2 km to hotel, Wangfujing Street is about 3km to hotel.
No.103, Di An Men West Street Back Lakes (Hou Hai), Beijing CN, China


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MIAMI: The Indians executed two transactions this afternoon concerning minor leaguers.
Right-hander Fernando Nieve was traded to the Athletics for cash considerations, and right-hander Joe Martinez was outrighted to Columbus.
Nieve appeared in 22 games for Columbus (20 out of the bullpen) and compiled a 5-3 record and 1.81 ERA. He walked 12 and struck out 55 in 44 2/3 innings.
Martinez, who was designated for assignment last week, is 2-6 in 19 appearances for the Clippers (16 starts) with a 5.88 ERA.
It's not clear why the Tribe would jettison Nieve, unless the club needs his roster spot for the promotion of a pitcher from Akron or is working on a deal to bring in a pitcher that would be assigned to Triple-A.


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Rivers of Ink
Write here! Write now!
Welcome to Rivers of Ink, the Mid-Columbia's only professional writers' conference. We are pleased to announce that Rivers of Ink has transitioned into a full two-day writers conference featuring opportunities and workshops in Honing your Craft, Publishing & Marketing, and Genre Specific. Join us August 2017 for this exciting event. Gain knowledge. Network with local authors. Meet publishing professionals. It's all right here at Rivers of Ink!
Registration will open May 1, 2017.
Note: New date this year – August 18-19! Now in its 9th year, Rivers of Ink focuses on quality writing, submissions, the road to publication, and the life of a published author. Features include keynote…Read more
For our 2017 conference, we have exciting news! We are moving the conference up from October to August so as to remove the conflict with school schedules. We hope to see you at the same…Read more
The winner of our final registration giveaway is Mike Langevin. Mike will receive a copy of Terry Persun's book, To Our Waking Souls. Mike can collect his prize at the conference, which starts on Friday. See…Read more
The good news? The 2016 Rivers of Ink Conference is happening in a little more than a week! The bad news? This is our last registration giveaway before the conference. All of you who have…Read more
Our lucky winner of this week's registration giveaway is Rhiannon Hulse. Her prize is a romantic duet generously donated by one of our workshop presenters, Krista Lynne Jensen. The duet includes Kisses in the Rain and…Read more
In the past years, we have provided advertising for anyone who would like to purchase space in the conference program, and we would like to do the same this year. However, the physical size of…Read more
For our next registration giveaway, workshop presenter Krista Lynne Jensen has kindly donated two books, Kisses in the Rain and With All My Heart. Be a sweetheart and register before Sept 26 and you'll be…Read more
Laura Kostad was the lucky winner of the registration giveaway for the week ending Sept 19. Laura will collect her prize - a copy of The Killing Machine by Terry Persun - at the conference. Congratulations,…Read more
For this week's giveaway, our very generous keynote speaker, Terry Persun, has donated a copy of his book, The Killing Machine. If you register by Sept 19, you'll be eligible to win this limited availability book.…Read more
The winner of this week's giveaway is Betsy Dickinson. This week's prize is a two-fer from our workshop presenter, Liz Fountain. Liz donated a "Women Who Don't Make Coffee for Men" mug and a copy…Read more
For this week's giveaway, one of our speakers, Liz Fountain has donated a coffee mug and a copy of one of her books, An Alien's Guide to World Domination. Even though Amazon describes Alien's Guide as…Read more
The winners of this week's giveaway are Jeanette and Greg Mendell. Jeanette and Greg both registered for one-day attendance on Saturday, October 8. That's the equivalent of one person registering for two days. So, they'll…Read more
Rivers of Ink is pleased that Amanda at Adventures Underground has agreed again this year to sell books on behalf of participating authors. Please provide (no more than) four or five copies of your book(s) to…Read more
Don't miss out on the Early Bird Sale, still going on now through Sept. 7. After that registration prices go up to $110 for the two-day conference. You don't want to be late, so make…Read more
No, not like that. For our next registration giveaway, DeeAnna Galbraith is giving the lucky winner the complete set of her romance novels: Chasing Glory, Delta on My Mind, and Gambling on the Goddess. This week's giveaway…Read more
Congratulations to Linda Lunde who won the registration giveaway for this week. Thanks to Terry Persun, Linda will receive a signed copy of his sci-fi thriller, Hear No Evil, when she attends the conference in…Read more
The 2016 Rivers of Ink Conference team is grateful to our keynote speaker, Terry Persun who is donating a copy of his sci-fi thriller, Hear No Evil, for our next registration giveaway. If you register…Read more
Congratulations to Donna Brown who has won the registration giveaway for this week. Whoo hoo! For registering early, Donna will receive a signed copy of the sci fi thriller Pod, written by our very own…Read more
Did you know that that October 8 is Indie Author Day?! From the Indie Author Day webpage: During the Inaugural Indie Author Day on October 8, 2016, libraries from all across North America will host their…Read more
For our next registration giveaway, Rivers of Ink is happy to announce we will be giving away a signed copy of Steve Wallenfels' sci-fi thriller POD to one lucky winner who registers by August 22nd. One…Read more
The winner of the first 2016 Rivers of Ink Registration Giveaway is Lois Olmstead. Congratulations, Lois! You'll be getting your $20 Starbucks gift card, sponsored by Seiders House Publishing, at the conference in October. Thanks…Read more
Good news for all of our local authors who also have day jobs! We've added single-day registration options. Early bird rates will apply until Sept 9, just like full, two-day registration. Check it out on…Read more
@InkRivers is now live! Follow us and keep up to date on all the exciting things we have planned leading up to our 2016 conference in October. And don't forget to register so you can be…Read more
If you haven't registered for the 2016 Rivers of Ink Conference, now would be a good time to do it! Seiders House Publishing will be giving away a $20 Starbucks gift card to one lucky…Read more
There are still some slots yet to be filled for presentations at the 2016 Rivers of Ink conference. Fill out your application before time runs out! See the application for specific instructions. Please submit: Presenter information…Read more
Rivers of Ink is happy to welcome Suzanne Selfors and Terry Persun as our 2016 Keynote speakers.Read more
The 2015 conference has ended and now it is time to start thinking about 2016! Click here, 2016 call for presentations, for the application to enter your idea for next year's workshops. Let's make 2016 Rivers of…Read more
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The Peace Of Christmas Eve
At Ghent five Americans—divided and far from home—held firm for a treaty that won their nation new respect, and began a lasting alliance
December 1960 | Volume 12, Issue 1
That answer spewed forth a torrent of words on the subject of Indians, but the British mandate on Indian pacification was accepted, however ungraciously. It was, said the American commissioners, similar to their own suggestions on the matter (suggestions which had been made, strangely enough, in September by the same John Quincy Adams who went livid when he saw the words in British handwriting). In conclusion, the Americans asked for a complete treaty project from the British, to which they would respond with one of their own. "May it please God," intoned Adams, after the note had been sent, "to forgive our enemies, and to turn their hearts!"
What the Lord did to British hearts will remain a celestial mystery. In any event, on October 17, while the British commissioners were considering their rejoinder, it was their turn to receive bad news from America. On September 11, Thomas Macdonough, working his ships as if they were water-borne carrousels, had outlasted a superior British naval force in Plattsburg Bay, and Sir George Prévost, who was to have severed New England from the not-so-United States, had sunk in spirit as his naval brothers were sinking in fact and promptly marched his intimidating horde back to Canada. A few days later, Robert Ross, the general who had put the torch to Washington, lay dying near unconquered Baltimore, listening to the same bomb bursts that provoked patriotic verse in Francis Scott Key.
The discouraging news did not, however, noticeably temper the next British note to the American commission. It insisted that the Americans accede to the principle of hold-what-you-have, specifying that a good part of Maine and some forts and islands should be given to Canada, and repeating the prohibition against the drying of fish on Canadian shores. On the matter of a treaty project, the British demurred. Their terms were clear, they said; it was up to the Americans to produce a plan. The American answer was prompt and negative, and it gave Lord Liverpool the queasy sensation of balancing on a seesaw that could not touch ground at either end. He wanted to break off the negotiations and fight, but he thought of the Czar, of Talleyrand, of the British budget, and wept. On the last day of October Anthony St. John Baker, secretary to the British mission at Ghent, trotted across town with a note that was brief, terse, and only too familiar. The British had given their terms. They had nothing more to say. They awaited the American project. They were, they neglected to say, stalling.
The American commissioners had in fact been discussing and composing a treaty project for two days when Baker surrendered his blunt message and a packet of London newspapers to four sober men, three of them the restless audience for an Adams monologue. Only Russell was missing; it was perhaps one of his greatest contributions to the progress of peace.
An occasional merchant, lawyer, and unlikely diplomat from Rhode Island, Jonathan Russell was a perverse and bristling mixture of acute self-adoration and gelatinous principle. Like a sulky little boy, he fumed when Gallatin forgot to tell him of a Ghent social invitation, and at the end of September he moved away from his condescending peers and back to the more appreciative companionship of the secretaries and messengers at the Hotel des Pays-Bas. Adams he hated. Gallatin he suspected. Bayard he dismissed. Clay, the man in whom "all the nobler passions have found their home," was his idol and, Russell hoped, his viaduct to a political future. In Ghent Russell's course was that of a wayward carriage, but in November he latched on to Clay and, usually, whenever the latter raised his hand two votes were counted.
Clay would have snickered had he known of Russell's praise. Clay was the epitome of crude, calculating, dice-throwing western ambition, and in him lay the source of the overstatement of American attitudes at Ghent. The British, he maintained, were nothing more than card players, faking a flush when they held a pair of deuces. At a time when his companions floundered in a vale of pessimism and made sounds like departing tourists, Clay blandly asked the British for his passport and sent Goulburn's spirits surging. But Clay was playing "brag." He later asked Adams if he knew how to play. John Quincy most surely did not. It is, said Clay, the art of "holding your hand, with a solemn and confident phiz …" Adams, however, could not put on such a "phiz."


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peluang usaha, Saham, Online Trading
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For developers and debug-willing Linux enthusiasts, the Intel GPU Tools 1.7 open-source release is now available.
The Linux graphics developers within Intel's Open-Source Technology Center have already prepared a fresh batch of changes that will land with the Linux 3.17 kernel -- even though the Linux 3.15 kernel hasn't been released yet and the Linux 3.16 kernel merge window opened early.
For many months now Intel has been working on RAPL support within the Linux kernel as part of their power-capping framework as a power feature for Intel hardware on Linux.
For those interested in DisplayPort MST support on Linux to support the specification's multi-stream transport ability, there is now a revised patch-set providing this support.
Intel has published a new Linux kernel patch-set that adds Quick Assist Technology support to Linux along with a driver to handle their DH895xxC hardware accelerator. This is a new chip for trying to accelerate cryptography and data compression tasks.
Intel will begin shipping the Core i7 4790K "Devil's Canyon" processor this month and thanks to Computex now getting underway we're able to publicly talk about this high-performance chip.
To complement the recent ACPI CPUfreq vs. Intel P-State Scaling With Linux 3.15 testing that was done using an Intel Core i7 Ivy Bridge Extreme Edition system, here's some similar tests done using a low-power Intel Celeron N2820 "Bay Trail" SoC within the Intel NUC.
Intel Broadwell processors will be supported by the P-State driver with the upcoming Linux 3.16 kernel release.
While improvements to Intel's open-source Linux graphics driver that explicitly target Sandy Bridge hardware is rare these days with the Intel OTC crew being busy with Broadwell, Haswell, and Bay Trail, there is an SNB improvement to report this afternoon. A patch-set has emerged for Sandy Bridge to implement layered rendering and in the process it takes care of a long-time OpenGL performance regression.
Beignet as the open-source project to provide Intel OpenCL support that works with Intel's open-source Linux graphics driver stack is beginning to show signs of maturity and progress so that Intel Linux desktop users can finally begin exploiting the GPGPU potential of their hardware.
Following the benchmarks I posted this morning showing Intel Haswell graphics having some OpenGL slowdowns with the newer Mesa graphics driver code, I tested a sharply different Haswell system to see if the performance differential was also to be found on this Intel ultrabook with Iris Graphics 5100...
As I wrote about when Intel launched the Z97 chipset earlier this month in preparation for the Haswell Refresh and Broadwell CPUs, the Linux compatibility for the new motherboards powered by the Intel 9-Series chipsets should be in good shape. One of the motherboards I have been testing since then is the Gigabyte Z97-HD3.
The 2014 release of Intel's OpenCL SDK for Windows and Linux is now available.
Intel has released a new version of their open-source PowerTOP utility for Linux systems to diagnose power consumption issues and make improvements to power management by individually analyzing the system's current power settings.
We're anxious to test out Intel's next-generation Broadwell processors but it doesn't look like they'll be out in time for "back to school" shopping but should certainly arrive in time for the holidays.
We're still a few weeks away from the release of the Linux 3.15 kernel but open-source Intel developers have already sent in another drm-next pull request to land more of their kernel graphics driver changes for Linux 3.16.
Intel this week has released their Intel Graphics Installer 1.0.5 for Linux, which ships their 2014Q1 open-source graphics driver stack. Supported with this quarterly update is now also Ubuntu 14.04 LTS while the other primary target, Fedora, is still obviously at version 20.
Today the NDA clears covering Intel's new Z97 and H97 chipsets, which are targeted for the Haswell-Refresh CPUs along with Broadwell CPUs later in the year.
Last month Intel announced a new, fan-less Intel NUC Kit, the DE3815TYKHE and it featured an Intel Atom E3815 SoC. While at first I immediately planned to buy one, now that they're available, I've changed my purchase order instead to another DN2820FYKH NUC Kit for Linux usage.
Daniel Vetter of Intel's Open-Source Technology Center is presenting this week at LinuxTag 2014 about the state of their Linux kernel graphics driver.
Last year on earlier versions of the Linux kernel we've uncovered performance issues around Intel's P-State / CPUfreq driver that was causing adverse performance in certain configurations. While it looked like most of the Intel CPU clocking issues were resolved in more recent versions of the Linux kernel, it looks like some Linux performance problems are present in Linux 3.14.
Intel Linux developers have been pursuing work on creating a DRM color manager for Linux to standardize some interfaces related to color management for the DRM GPU drivers.
For supporting Linux networking on very small embedded systems like the Intel Quark, developers at Intel are working on a lightweight networking stack to fit on such systems.
For several months now Intel has been working on graphics virtualization support for their HD Graphics hardware on Linux for use by virtual machines. One of their big projects has been XenGT for mediated GPU pass-through with Xen, but here's a full rundown of what they have going for them right now.
Intel developers landed the bulk of the support into Mesa for supporting the GL_INTEL_performance_query extension, which should be able to assist Linux game developers and driver developers in better optimizing software/games for the open-source Linux graphics drivers.
Eight months ago today was the first development release of xf86-video-intel 3.0, the X.Org Intel DDX driver, with support for SNA by default and XMir. While Intel reverted their plans to support XMir, this major Intel DDX driver update still hasn't surfaced.
Intel has submitted their first drm-next pull request of the Intel Linux graphics driver changes aimed for the Linux 3.16 kernel.
The Intel P-State driver that's found in modern versions of the Linux kernel as a replacement to the older CPUfreq code is getting tuned for better performance while boasting greater power-savings.
A Linux developer at Intel has proposed a new CPU load metric for power-efficient scheduling by the Linux kernel.
Intel next week is expected to begin shipping a new NUC Kit that is fan-less and suited for "value-conscious businesses and organizations." This new NUC Kit has just a single-core "Bay Trail" processor that runs at 5 Watts but overall it looks like it could have some interesting applications if the price is right.
1102 Intel news articles published on Phoronix.


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Sir: In the wake of the Stephen Lawrence inquiry, the Prime Minister suggests that all public organisations should review their attitudes and practices for institutional racism. Noting that under the Government's Immigration and Asylum Bill, Immigration Officers will be given new powers to search premises, and arrest asylum seekers"using reasonable force if necessary", and remembering the tragic death of Joy Gardner, it has to be asked whether the Government's bold stance on rooting out institutional racism will apply to the Immigration Service. Or not?
London SW12Reuse content


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While on hand for London Men's Fashion Week this June, Tokyo-based brand BEAMS had the opportunity to sit down with four different designers to capture their varying takes on their brands, as well as their upcoming Fall/Winter 2012 collections. Spotlighting the likes of 1205′s Paula Gerbase, Patrick Grant of E. Tautz, Claire Malcolm of Hardy Amies and Sibling's Sid Bryan, Joe Bates, and Cozette McCreery, the 10-minute video catches the designers' musings on the state of menswear, inspiration, Savile Row, the London design scene, and much more.


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Children are set up for success when they enter school prepared to learn.
Good school attendance maximizes learning and helps students stay on track.
Engaging educational opportunities over the break prevent summer slide.
Parents are their children's first teachers and most important advocates.
The Oakland Literacy Coalition (OLC) is a collaboration of literacy service providers, foundations, businesses, public agencies, the Oakland Unified School District, and other community partners committed to the goal of equipping all Oakland children with the life skills of reading, writing, and communication by the end of third grade. Oakland Reads 2020 is an OLC initiative.
by Jessica Scadron, MDC Network "The colored pencils are my favorite," said Talia, a soft-spoken, excited 8-year-old with... Read post »


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"Nintendo DS and DSi 9-in-1 Accessory Kit in Black" is not available for sale online.
This item may be discontinued or not carried in your nearest store. Please call your local store to check in-store availability before heading there. For informational purposes, the product details and customer reviews are provided.
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- Nintendo DS and DSi 9- in -1 Accessory Kit will help you keep your devices powered up at home or away
- Kit includes:
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- USB charging cable for DSi or DS Lite
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The Ultimate Desktop Biotope!
JBJ is pleased to announce the next generation of nano-cubes to our ever growing list of JBJ Aquarium Products. The newest models reflect the same classic nano cube look that has proven successful for almost a decade a now but has been combined with more efficient technology. Most notably these new next-gen nano cubes have replaced the hot power compact bulbs that necessitate annual to bi-annual replacement with a cool running, long lasting, low power consumption LED lighting system. JBJ continues to prove that small things really do come in small packages. Whether you are a novice aquarist trying his or her hand at their first freshwater aquarium or an advanced marine aquarist looking to add a nano-reed to your desk, JBJ has the right tank for you.
Advanced Features:
6 Gallon Glass Cube
Still in place in the next generation nano-cubes are the patented curved glass, which allow for a unique and dynamic panoramic view of your aquarium and all of its inhabitants.
Integrated 3-Stage Filtration:
Being an all inclusive biotopic system for aquatic denizens the nano-cube has discreetly hidden in the rear of the tank a small yet powerful and effective 3 stage filtration chamber system. The first chamber includes an intake with a protective screen, the second chamber is empty and can be utilized with the included filter media or any other media you see fit. The third chamber consists of a quiet and efficient 106 GPH return pump which directs water back into the display area of the nano-cube via a directional nozzle. Filter media included with your nano cube;
*Biological - Ceramic Rings and Plastic Bio-Media is also included, these too serve as breeding grounds for beneficial bacteria that assist in breaking down harmful organics such as ammonia and nitrites.
Despite utilizing the much cooler running LED lighting system, the next generation Nano Cubes still include (2) 50x50mm cooling fans within the canopy to aid in cooling and aeration of the electrical equipment in the canopy to prevent damage via humidity build up.
JBJ LED Flip Top Canopy and LED lighting system
While only concealing 6 LED`s of approximately 1.3 watts each (3: 10,000k and 3: 20,000k). These high intensity LED diodes put out three times the amount of an equivalent power compact fluorescent system (with the assist of an integrated reflector) while still remaining cool to the touch. This means less evaporation, and less chance for a catastrophic salinity change if utilizing the nano cube for brackish or marine tanks. The canopy still houses built in cooling fans that draw air out of the canopy to assist in dealing with heat generated by the tanks, as well as managing moisture. The LED`s are not only more efficient but cost saving as well, utilizing an electronic ballast and a lifespan of 50,000 hours before diminishing in output compared to about 3,000 hours with a power compact system.
Approximate PAR readings for the 6 Gallon LED:
340 at 2"
165 at 6"
60 at 10"
CE Approved
Manufactured with the highest quality components for trouble free performance.
Dimensions: 11.81" (L) x 13.39" (W) x 11.81" (H)
Capacity: 6 gallons
Power Supply: AC110V-60Hz
Pump (included): 106 GPH
Lift: 1.3m
What`s in the Box:
106GPH Pump
LED lighting system
Integrated 3-Stage Filtration
Product Manuals & Documentation
JBJ is a top-of-mind brand name in freshwater and saltwater aquarium supplies. The company is committed to innovation and manufacturing only the absolute highest quality equipment. JBJ's philosophy is "to create products that provide extra value" to hobbyists. JBJ produces hundreds of aquarium products including lights, filters, heaters, UV sterilizers, wavemakers and top-off systems. The company is best known for their affordable line of Arctica chillers and the best-selling Nano Cube aquarium series. We carry the gamut of JBJ products and accessories and are happy to provide you free technical support while you're setting up your new equipment.
Accessories for JBJ 6 Gallon Nano Cube LED Aquarium
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Kukla's Korner Hockey
It Just Won't Die
by Paul on 10/16/07 at 01:38 PM ET
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from William Houston of the Globe and Mail,
Among hockey broadcasters, speculation has Toronto Maple Leaf general manager John Ferguson fired in November if the team continues to lose more than it wins.
Who would replace him? Colin Campbell, the NHL's Toronto based head of hockey operations, seems to be a favourite. But would the league allow him to leave his job in mid-season?
Would Scotty Bowman take the job?
Two views Bowman:
Filed in: NHL Teams, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: scotty+bowman
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This review is from: ASUS USB-BT211 USB 2.0 Mini Bluetooth Dongle
Pros: *Cheap
After installing the driver from the small CD it worked great. Then I had re-install my OS and lost the driver cd.
Cons: Windows 7 Ultimate 64bit:
If you uninstall it and lose the disk get ready to have driver problems. I've tried all three available drivers for this thing and none of them would work. Windows will try to install the MotionJoy driver which will not work.
Other Thoughts: Finally got it to work
*Uninstall everything labeled Bluetooth
*Reinstall the Bluetooth suite.
*Manually ran "BtvStack.exe" and "AthBtTray.exe" as Administrator
*It will default to a communication device depending on your BT device. If so just set it to default audio device and everytime you turn your BT device on it'll connect
This review is from: G.SKILL Sniper 8GB (2 x 4GB) 240-Pin DDR3 SDRAM DDR3 1333 (PC3 10666) Desktop Memory Model F3-10666CL9D-8GBSR
Pros: Does what it's supposed to do. No glitches since installed in a new build since 5/6/2011. My PC stays on for weeks on end unless the power goes out because of weather issues.
Cons: None
Other Thoughts: Wished it was cheaper of course.READ FULL REVIEW
This review is from: CORSAIR Enthusiast Series TX650 650W ATX12V/EPS12V 80 PLUS BRONZE Certified Active PFC High Performance Power Supply
Pros: Everything in the specs that I wanted and has performed as I had hoped.
Running 8 Drives, an SSD and optical drives. The PC is always on unless the power goes out for some reason due to weather. No glitches since 5/6/2011
Cons: This isn't really a "con", but I just wished at this price it was modular.READ FULL REVIEW


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Monday, 16 June 2014
Fireman Fun
These are the days.
Kudos to the service folk who attend these days; the police men, the guide dog fundraisers (plus dogs!) and firefighters.
The firefighters in particular make a lot of dreams come true just by letting small children climb into those huge cabins and stick a fire helmet on for five minutes.
Amongst all the bric-a-brac, second-hand books and bouncy castles, the fire engine is certainly the most attended and most 'wow' some event for small children - my two always make a bee-line for it!
And I am always amazed at the patience and diligence the lovely firemen display when dealing with wee kids and sometimes quite pushy parents.
Thank you firemen and women, for making little people happy!
Posted by Genna Millar at 04:23
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Description: The seventh edition of this dermatology atlas follows the same format as its predecessors: beautiful color clinical photographs with succinct discussions of clinical presentation, diagnosis, laboratory evaluation, treatment. Helpful tables detail the differential diagnosis for similar clinical presentations and how to distinguish them. Excellent clinical tips appear throughout the book. Curiously, this edition is smaller than the previous one of four years ago by over a hundred pages, but I can't see where that has compromised the value of the book in any way.
Purpose: The purpose is to provide an excellent color atlas for learning dermatology.
Audience: It is intended for medical students, dermatology residents, and all other medical professionals. This atlas is an all time favorite of mine. It is a wonderful way to learn and/or brush up on conditions you do not encounter every day but do not want to forget about.
Features: The latest edition adds a few new entities: Nocardia, erythrokeratodermia variabilis, and penicillinosis. There is a new photo of Lyme disease on the face. Entities that were previously categorized under miscellaneous now appear under their own category, e.g., neutrophilic dermatoses. The chapters on life-threatening dermatoses and severe drug reactions are examples of the valuable information it presents. The book lends itself to be a rapid resource to refresh one's memory.
Assessment: This is one of the best clinical atlases around, and it is portable. Most of the information in this edition appeared in the sixth edition, with a few minor updates.


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[Date Index] [Thread Index] [Author Index]
A question about derivatives of quadratic products
Hello, I am a new user of mathematica. I met a question about derivatives as following: D = Norm[w, 2]^2/2+sum(αi(yi(w.x+b+sqrt(w.M.w))-1)) (which i=1 to n) w and x are two-dimension vectors, yi is a number either -1 or 1, b is a number, M is a 2*2 matrix, αi is a lagrange coefficient. I want to get the value of w when D's derivative on w is equal to zero. But many errors happen, and it seems mathematica does not know what it should do next. Can somebody help me? Many thanks for your kind help.


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The staff at TCM prides itself in its culture. This group thrives on teamwork, respect, and fun (and good food)!
Mike Logan - President
A recovering (brief) collegiate cross-country and track runner, Mike spends most of his time running these days as a competitive amateur soccer player. He joined the TCM team in October of 2015 as the organization's inaugural staff president, charged with of evolving the organization's reach as an active-living events organization. Mike is a board member of the Sanneh Foundation and also serves as an executive committee member of the British American Project. Prior to joining TCM, he was an external affairs executive at Comcast and Target Corporation. Mike spends his free time travelling with his wife Jen and chasing his obstinate basset hounds.
Virginia Brophy Achman - Executive Director
Virginia joined the TCM team in June 2000 as Race Operations Manager, became Race Director in 2003, and Executive Director in 2004. She recently re-joined the Board of Directors for Running USA, also serving on the advisory Board of Directors for Team USA Minnesota and Bolder Options. In December 2008, she was elected Chair of Women's Long Distance Running for USATF. As a volunteer, Virginia has been involved with Susan G. Komen Twin Cities for many years, and has served as Chair of Registration for a 46,000 person event for the last 15 years. Virginia is a marathon runner, and has completed more than ten marathons!
Terry Ryan - Director of Operations
For some of us, a love of running comes natural and for others, it has to be learned. Terry is one of the others. As a junior high student, Terry dabbled in other sports, mainly football. He thinks his love for running developed as he was being chased down the football field by guys twice his size, where outrunning his opponents was nearly a matter of life and death. He's continued to run on and off over his adult life, running 12 marathons and countless other road races. He's been a coach for a local running group and a volunteer for a number of road races, including the Medtronic Twin Cities Marathon. Terry joined the staff in the summer of 2006.
Breanne Hegg - Marketing & Media Director
Breanne's loves of running and marketing came together in this position, which combines her many years of experience in marketing with her passion for physical fitness. She knew she'd found her home when she was presented with a stack of tech shirts on her first day and was welcomed at the lunch table by several coworkers who had also brought quinoa. Breanne enjoys the balance of diving into spreadsheets, analytics and marketing plans while also exploring the creative execution of TCM's brand. A fiercely proud Minnesotan, Breanne can often be seen running around the Lakes with her husband and two young daughters.
Amy Farsht - Director of Partnerships
Joining Twin Cities in Motion in April 2016 combines Amy's love of fitness and community with her professional experience in partnerships and event marketing. Amy enjoys building meaningful and lasting relationships between brands, companies and consumers by creating positive and impactful partnerships. With multiple previous positions in corporate sponsorships, special events, partnership marketing and merchandising in the retail and legal industries, Amy is thrilled to continue her career journey at TCM. Volunteer work allows Amy to focus on inspiring and promoting women to achieve their professional goals, hopes and dreams as a founding member of the Ellevate Network Twin Cities Chapter and with Dress for Success. Amy's other passions include travel, running (when her back allows it), yoga, cooking and entertaining. She can also be found enjoying Lake Harriet in the peaceful morning hours, on weekends supporting the fantastic local chef-driven restaurant scene with her husband Dan and playing referee to their two young and very active sons.
Elizabeth Vincenty - Race Director
Elizabeth has been passionate about events since she learned you don't need to have a birthday to throw a party at the age of five. Since then, all signs have pointed her towards a career combining her love of sports and events. Shortly after receiving a degree in Sports Marketing and Management from Indiana University, Elizabeth found her calling working on the Chicago Marathon and continued to work on the event directly and with event partners for nearly 20 years. Along the way, she worked on dozens of other events and couldn't wait to get more involved with the Medtronic Twin Cities Marathon when she moved to Minneapolis with her husband and two school-aged children in 2014. A dream realized, Elizabeth proudly accepted the role of Race Director for TCM in 2016 and has run with it! When she isn't planning events, she enjoys running (at a leisurely pace), playing volleyball, cooking, photography and exploring the Twin Cities and the rest of the great state of Minnesota with her family.
Catherine Bishop - Registration Coordinator
Catherine keeps everything in working order with our event registration. You'll often find her working with duo monitors and her Shih Tzu, Dutchess, lying nearby. Catherine started working for TCM in 1999 before online registration was available and was paid $.25 for each registrant she entered in the database. She did seasonal data entry for 5 years before coming on board in a year-round capacity. Not really a runner before working at TCM, Catherine has worked her way up to being a half marathoner!
Lindsey Altermatt - Administrative Coordinator
Lindsey, the voice of TCM keeps the physical office in motion by keeping up with office supplies, providing administrative support to managers, and providing every day frontline customer service. Lindsey also spends time helping with course operations. Favorite activities include: singing while she works, drinking wine around a bonfire, keeping up with her two dogs and two cats, gardening, biking, and spending time with her husband and daughter! She especially loves curling up with a book and admiring the view from her high-rise condo in downtown Minneapolis.
Sandy Unger - Youth Programs & Community Outreach Manager
Sandy is a recovering New Yorker, having been born and raised there. She settled in Minnesota right out of graduate school and fell in love with the people and the green spaces and only goes back to NY to visit friends and for an adrenaline rush. After spending a "lifetime" working for multiple municipal Park and Recreation Departments, School Districts and non-profits, she found a place with TCM. When not helping kids develop healthy lifestyles by learning to love running, she can be found traveling the world, geocaching, collecting matchbooks, cooking, and providing leadership to local and national non-profits helping to prevent domestic violence.
Vanessa Graetz - Online Engagement Manager
Vanessa joined TCM staff in spring of 2012. Originally from Green Bay, Wisconsin, she's now enjoys her time exploring Saint Paul. Also known as Webnessa, you can find her maintaining all TCM accounts online and near the finish line on race day. Vanessa spends her free time soaking up the sun, traveling to visit friends, and posting pictures of coffee on her Instagram. She likes training for and completing half marathons, and became a marathoner thanks to the encouragement from her coworkers at TCM.
Kelli Bartholow - Operations & Volunteer Manager
Kelli, a former Twin Cities In Motion intern and volunteer, joins the full-time staff after serving as the Outreach Coordinator at Bolder Options, a local non-profit organization focused on healthy youth development through mentoring, wellness activities, and leadership opportunities. Her responsibilities at Twin Cities In Motion include recruiting and organizing the 6,000 volunteers needed to manage our year-round events. Kelli grew up in Shoreview, MN and graduated from the University of Minnesota, Twin Cities with a B.S. in Sport Management. Kelli has a passion for running and loves spending time with her two favorite people in the world: her growing nieces, Zoë and Cora.
Charlie Mahler - Media and Communications Manager
Charlie joined TCM after wearing many hats in the running industry. A former college coach and the founder of the popular running website Down the Backstretch, Charlie is pleased to work for an organization that has long been important to him. A spectator at the first Twin Cities Marathon in 1982, Charlie won the inaugural Medtronic TC 10 Mile in 1999 and served the organization in various capacities prior to joining the staff. Charlie enjoys running, reading, cycling, and being active in the outdoors.
Colleen O'Connell - Accounting and Program Support Specialist
Number crunching is the name of the game for Colleen! Coming to us from REI, Colleen joined TCM in December 2013. An avid runner, Colleen can often be found around the Saint Paul trails training for one of her marathons or half marathons. When she isn't laced up, she can be found cozied up on the couch with a good show, a good book, and some good wine!
Ed Whetham - Race Operations Manager
Stemming from his experience as store manager for Run and Fun, and serving as the LDR Chair for USATF MN, Ed played several key volunteer roles within the Twin Cities In Motion organization such as logistics with our youth events, and most recently was the division director for the Red, White & Boom! TC Half Marathon before officially joining the staff in August 2014. When Ed isn't at his desk filing permits, and procuring myriad race supplies, he can be found schlepping pallets around the warehouse, or out at the race sites taking measurements. Favorite activities include cheering on the Vikings, running and spending time with his four cats!
Sara Brennan - Corporate Relations Manager
Sara was born and raised in the St. Paul area and attended the University of St. Thomas, graduating with a B.A. degree in Marketing Management. She joined the TCM Staff in June of 2014, after running her first marathon at the Medtronic Twin Cities Marathon the previous year. Sara began her TCM career as an intern and transitioned into a full-time staff position in January of 2015. Prior to TCM, she worked for her family-owned fence company. When not working, Sara likes to spend her time playing bingo, doing jigsaw puzzles, and running around the lakes.
TBD - Event Experience Manager
Autumn Eklund - Office Assistant
Autumn is Lindsey's right-hand when it comes to any tasks needed to be done in the office, along with being in charge of any interactions and orders with our online store. Autumn was never much of a runner before working at TCM, but with the support from staff, she decided to register for her first marathon! She is finishing her Retail Merchandising degree from the University of Minnesota, and enjoys exploring everything the Twin Cities has to offer.
Cyndi Hovey - Corporate Relations Assistant
Cyndi feels blessed by the opportunity to continue combing her talent and love of movement motivation, community outreach, and event planning for TCM as the Corporate Relations Assistant. She is energized by creating spaces where people gather for entertaining, engaging and enjoyable events. Her spirit animal is a lion: strong as an individual, but much more powerful within community. Cyndi calls herself a "mover" and tries to live a life where play and exploration replaces "working out." She prides herself in being a year-long biker in Minnesota. If she's not biking, she can be found gettin' after it with November Project Minneapolis, practicing yoga, rock climbing or… eating (her life philosophy: food is good). If you tell her when your birthday is, you're likely to receive some type of baked good!
Chelsea Kipp - Marketing & Communications Intern
Mark Gilkerson - Sports Management Intern
TBD - Corporate Partnerships Intern
TBD - Event Experience Intern
TBD - Merchandise And Office Assistant
TBD - Volunteer & Community Outreach Intern


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Cosmoquest Astronomy Hour, Sept. 26, 2012: Curiosity update
Emily Lakdawalla and Fraser Cain talk about Gale crater, the site of Curiosity's investigation on Mars, and how to look at HiRISE images of the site.
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awe-inspiring science.
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SMS Messages that appear randomly????
This may sound completely crazy but I have have two different random messages appear on the stock SMS that appear to be sent out by me. It appears to be a random jumble of words. The first happened on Thursday night, I had sent a text to a friend and left the phone on my kitchen table. About a half hour later my phone buzzes and my friend has sent me the WTF? quote. The exact same scenario happened last night to a different friend. Has someone hacked my phone? What is going on? Any suggestions for a fix? Should I use a non-stock SMS program? If so, suggestions?
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Family Law
Family Law Questions? Ask a Family Lawyer Online.
Yes, there is nothing that would prevent you from filing personal bankruptcy while you are in the midst of a divorce. In fact, it is quite common for one spouse to do so to get an entirely fresh start once the divorce is completed. This will discharge virtually all debts that you have (student loans, child support, and a few others excepted) and will make your spouse solely liable for any jointly acquired debts. In turn, this usually forces the other spouse to file as well because then they are solely liable for the debts.
So if we haven't reached the point in our divorce to get debts assigned, then I still have time to file?
How is this viewed by the court and it there nothing the judge can do about assigning me debt if I have had it discharged in bankruptcy court?
Sure, you would just list all debts, even if they hadn't been assigned to you yet to cover all possible assignments.
The court wouldn't have any thoughts one way or the other as bankruptcy is covered under federal law which trumps state laws (which cover divorce). The judge can't assign you debts that are in the process of being discharged.


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Education, Education, Higher Education, Higher Education, Science & Medicine, Science & Medicine, Natural Sciences, Natural Sciences, Technology, Technology, Tech News Tech NewsFollow
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The Naked Scientists flagship science show, includes the latest science news, interviews with top scientists, hands-on science experiments and answers to your science questions.
June 1st, 2009
Episode 170 of 1119 episodes
How does nature inspire technology and engineering? We find out how bamboo may make effective wind turbines, and how the material that makes up locust tendons could soon be in your shoes and electronics!
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The "American Idol" tour came through Cleveland today, and I ambled up to the press event this afternoon. A few notes about how it worked, and what came of it, after the jump.
I had interviewed Danny Gokey awhile back for an advance story on the tour, which ran in Thursday's Beacon Journal (and is on Ohio.com), so I could have taken a pass on today's event. But this was still an opportunity to meet other performers. And there is always insight to be had from sitting in the same room with someone, as well as a chance to become a face to a performer I may have to interview again down the road. Not that I assume I would be remembered; in fact, considering what these young people have to go through, I'd be impressed if they remembered much of anything today.
They had ridden into town from Pittsburgh today, then had various business to do, including interviews and a meet-and-greet, then had the concert and finally were going to hit the road to Columbus tonight. Tomorrow will be a day off before they play in Columbus on Tuesday night, but it's still a bit of a grind. "It's what we do every day, the same routine," Allison Iraheta said. "Everything's the same." There's lots of time sleeping on the bus, or watching things. Anoop Desai mentioned they had been watching the first season of "True Blood," Michael Sarver recalled "Step Brothers."
This press event today lasted about an hour. Five of the performers -- Desai, Sarver, Iraheta, Adam Lambert and Scott MacIntyre -- met with reporters in round-robin fashion; I was seated at a table and the performers came to me, or to other tables with other reporters. They were unfailingly nice folks, very easy to talk to, and consistently interesting. It's an awkward process on both sides, since they are repeatedly asked some of the same questions in short order, and I was at once trying to cover some of the same ground with each (plans post-tour, music they're listening to), but also to pay attention to what they had to say, so it's not all a formality. Still, it offered a sense of who they were beyond the confines of "American Idol," and each in different ways made clear that what you saw on TV wasn't a full portrait.
For one thing, seeing them in person is a reminder of how young they really are -- at least, young from my gray-haired point of view. Very mature, very composed (although also freely bantering and rough-housing with each other) but still young. And they can see a big world stretching ahead of them; 'Noop's moving to LA to further his music career, Adam's album should be out in November; Adam, Allison and Scott all talked about writing songs.
And, for the old guy here again, there's a music gap. "Idol" traffics so heavily in songs recognizable to a wide range of viewers -- which means a sizable dose of oldies. Their own taste is, as you would expect, strongly contemporary and wide-ranging; Scott noted that on the show he had been pegged "the adult-contemporary guy," not long before talking about his fondness for Jimmy Eat World and "punk pop."
Each interview was no more than 10 minutes, but you can gather a lot of string in a pretty short time, especially when you and the person you're talking to are both focused and used to the system. (I remember years ago doing a rapid-fire interview with an actress in which we covered a lot of ground very quickly. When we finished and I noted how swiftly it had gone, she said, "Do you know how many of these I've done?" And she was just talking about that show, on that day.) Now the problem is to figure out what I'm going to do with the information. I hadn't really planned to do a full print story, but there may be something there. If nothing else, I'll do some themed notes here.
Today's theme: What are you listening to these days?
Anoop Desai -- Jazmine Sullivan's latest album, the new Maxwell, Keri Hilson. "The music that she writes -- a lot of it is in my vein, but what makes it is the production. ... As a singer on the show, you don't get to experiment a lot with the production, and that's part of the sound I'm looking for."
Allison Iraheta -- Yeah Yeah Yeahs, Keisha Cole, Kings of Leon.
Michael Sarver -- "Been listening to Robin Thicke. I love his soul. A lot of Rascal Flatts. A lot of Michael Buble. He relaxes me. ... That's why it's interesting that anyone thought they could pin me down to one genre." Still, he plans to focus on country for the time being, although he's aiming for country with a dose of soul.
Adam Lambert -- Peaches, Lady Gaga, Muse, IAMX. "He's a British artist. He's amazing. ... He used to be lead singer for the electronic group the Sneaker Pimps. He's had a couple of solo albums out and they're great. ... The production's really interesting. It's electronic but it has an organic-ness to it. It's melodic and vocal at the same time. ... It's kind of dark and theatrical but yet there's a beat to it."
Scott MacIntyre -- Jimmy Eat World, Matt Nathanson ("someone I just discovered"), John Mayer and "I'm listening to Scott MacIntyre. I do that a lot. ... I released six independent CDs before 'American Idol' and they're still floating around out there." He also has some new tracks on his MySpace page.


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Hearty Meals – larger portion meals, 500-565g
Two succulent steam roasted chicken breasts in a tasty rich chicken gravy. Served with roast potatoes and a delicious mix of broccoli, carrots, peas & sweetcorn.
Celery Free, Mustard Free, Soya Free, Beef Free, Garlic Free, Mushroom Free, Alcohol Free, Fish Free, Crustacean Free, Mollusc Free, Sulphites Free, Cheese Free, Milk Free, Egg Free
Pre-heated oven 170 C/325 F/Gas 3-4. If fan assisted 150 C/300 F. Cook until piping hot. Typically 50/55 minutes or longer if necessary.
Cook from frozen. Position the plastic container in the centre of the microwave oven. Cook on FULL power.
If you use our Mikrofix microwaves then this meal requires number 4
Store at -18 C, do not refreeze once thawed.
potato, cooked chicken breast (25%), water, broccoli, carrot, peas, sweetcorn, vegetable oils (palm, rapeseed, sunflower), cornflour, dextrose, tomato puree, starch, salt, yeast extract, natural flavourings, fully refined soybean oil, caramelised sugar, sugar, chicken stock, dried onion, rice flour, pepper
Allergy Advice: For allergens see ingredients in CAPITALS
Please note that ingredients may change from time to time, meaning more than one recipe could be in circulation. Whilst every effort has been made to ensure all variants are detailed here, please refer to the product labels for the exact specification of any individual dish. If you have any concerns regarding ingredient changes, please ask when placing or receiving your order.


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No Closing Costs Refinance Loans And MortgagesFebruary 23, 2017
When you take out some kind of borrowing like a mortgage or loan there are many choices on how to raise the finance and one option is to have a no closing cost refinance loan. Simply put, you can choose to pay the required closing costs when you first take out the loan or alternatively you can pay for them throughout the life of the loan.
This method of finance agreement is known by many different terminology but all essentially mean the same thing. You may have heard of "no fee refinances", "no cost mortgage refinances", "no cost refinance loans" or sometimes "no cost refinances". These terms often provoke confusion but be assured they all allude to the same thing – a mortgage refinance agreement which has very small closing charges.


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