text:
Danny Boyle, the film director masterminding the opening cermony of the London Olympics, has pleaded for the start time to be delayed till sunset to allow his show maximum visual impact.
Boyle wants darkness to have fallen so that the fireworks display is seen to best effect but it means an hour and an half delay from the planned 7.30pm opening and could cause chaos for anyone trying to get home from the ceremony.
By delaying the start of the 2012 Olympics opening ceremony to 8.55pm, as desired by Mr Boyle, according to the Sunday Times, guests who stayed on until the end in East London wouldn't get to start their journeys home until after 1am.
The crowd at the ceremony is expected to be about 80,000 and a further 130,000 are forecast to watch it on giant television creens erected in Hyde park, Victoria Park and close to City Hall. there is particular concern that a late start and finish would be unfair on elderly guests, such as the Queen, who would be 86, and Prince Philip, who would be 91.
Transport for London, which has reponsibility for underground trains and buses in the London, had been expecting the last service out of Stratford, where the Olympics are to be held, to run at 1.30am.
However, it is possible they would be willing to put on extra services out of Stratford and to other parts of London should the Olympic organisers agree to a late start and finish to the ceremony.
Mr Boyle, the director of Slumdog Millionnaire and Trainspotting, has promised an "epic and intimate" show which would be diluted by daylight.
A further hitch caused by his request for a delay is that thousands of brochures have already been published with 7.30pm given as the start time. The Olympic count-down clock would also have to be adjusted.Reuse content


text:
Price on Application (POA)
An abbreviation for "Price on Application" which indicates that price is not quoted publicly and will be revealed to qualified occupiers.
POA i
This Property is unavailable
Pare Ferryman forms part of the established Newbridge Road Industrial Estate, situated approximately 2.5 miles to the west of Newbridge, 1 mile to the east of Blackwood and 7 miles to the north of Caerphilly. Junction 28 of the M4 and Newport is approximately 10 miles to the south and accessed via the A467. Unit 1 offers a high bay industrial / warehousing of steel portal frame construction with profile clad elevation under a pitched roof. The unit has been sub divided to provide 3 self-contained units.

subset: commoncrawl


text:
Physicians and Blogging
Authored by:
Nrip NihalaniEntrepreneur, A Hands-on Health IT Evangelist, Co-Founder Plus91 A firm believer and advocate of collaborative usage of information and innovation with interests in Innovative and Useful uses of Technology to improve Healthcare Delivery in constrained scenarios. Nrip has been involved in Strategy Design and Technological Implementation in the areas of Health Care and Hospitality for 10 ...
Other Posts by Nrip Nihalani
» Already a member? Login now to comment!
» Not a member? Register to comment!
Erick Kinuthia says:
Interesting post Nihalani. Blogging should be an every day task for physicians. Marketing has gone digital making it more fun to engage in and even bring them closser to the patients. Why not blog physicians?
Erick Kinuthia
Team Mdwebpro
Latest News
"It is quite safe to say that local search has been becoming more and more vital, whether you're a local hospital or a national shop, a local SEO strategy seems to be a key to driving more customers through your clinic. Ever since Google's Hummingbird update landed, more and more users are seeing more personalized, relevant, and even localized based results for searches!"
"Actually I do not agree with this article. Sure some cases may be a case of food poisoning. I just had a 24 hour flu yesterday. I had no stomach issues. No constipation, no diarrhea, no stomach cramps. I had severe body aches from neck all the way down to my feet, I had a headache all day, I had a ..."


text:
The catastrophic descent into panic that is inevitably produced by self-diagnosis on the internet - a series of Google searches that builds from the gentle enquiry of 'Why does my chin feel warm?' to the panic of 'Strange, flesh-eating viruses', 'How long have I got?' and 'Tips on painless euthanasia'.
Thanks to guardian.co.uk who have provided this article. View the original here.


text:
Quiche Au Roquefort
|Roquefort cheese
|3 Ounce
|Cream cheese
|6 Ounce
|Softened butter
|2 Tablespoon
|Whipping cream
|3 Tablespoon
|To Taste
|White pepper
|To Taste
|Cayenne pepper
|To Taste
|Minced chives
|1⁄2 Tablespoon
|Pastry shell
1. Preheat oven to 375 degrees.
2. Blend cheeses, butter and cream thoroughly and beat well adding eggs.
3. Season with salt, white pepper and cayenne pepper.
4. Stir in chives and pour filling into pastry shell.
5. Bake for 25 to 30 minutes until quiche has puffed and top has browned.
6. Cottage cheese may be substituted for cream cheese.
7. Serve with garnish as desired.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 427 Calories from Fat 198
% Daily Value*
Total Fat 35 g54.3%
Saturated Fat 13 g65%
Trans Fat 0 g
Cholesterol 135.9 mg45.3%
Sodium 438.1 mg18.3%
Total Carbohydrates 19 g6.5%
Dietary Fiber 0.12 g0.48%
Sugars 1.5 g
Protein 10 g19.3%
Vitamin A 16.7% Vitamin C 1.5%
Calcium 13.8% Iron 3.1%
*Based on a 2000 Calorie diet


text:
- 2,328 Posts. Joined 3/2009
- Location: New Jersey USA
- Select All Posts By This User
I gotta stop reading this thread. Bought 7 cans past few weeks and didn't even bother to open them. Shame on me.
You should open and use those headphones quickly. To date, the only semi-recent headphone that I've known to have gone up in value is the Denon AH-D2000, 5000 and 7000 series. Time's a ticking.
There's a D5000 for sale right now in the FS/T forum. He's asking $525.00, here is the link:
Well worth it. Spend your "mmoney." The D5000 is a terrific HP and the replacement version of it is something like $700. If you can find a "like new" set for $500ish you'll be glad you made the investment.
I got mine pair in like new condition for only $455 and I would have paid $100 more after I saw how beautiful they were and the sound is jaw dropping. I keep thinking about selling them because I could get more than what I paid for them but I can't bring myself to part with them. Only way I give them up is if I get the D7k's and like them more than the 5k's.
On that note, does anyone know where you can get JMoney pads? Or are the angled pads from Lawton Audio better?? Does anyone have any experience with either and where is the best place to pick them up.
Funny, I sold all the headphones I started out with recently and they had all gone up. The Sony XB700's and Sleek Audio SA6's in particular sold for much more than I paid for them....
At this point, the only J$ pads available would be pre-owned. They crop up from time to time on the For Sale forum here.
I'm glad I got both of the Denon top tier here at home, D5000 & D7000 definitely worth the money, can only see these phones going up in price as time goes by.
Creative online store is having a storewide sale on selected products.
Use coupon code - 13SPRING for 25% off
Moon-Audio is having a massive sale. If you've got a facebook, make sure to like them, they post a ton of deals.


text:
Atonal, non-rhyming blown out anti-pop hip hop. The new kids will set it free.
In my mind I was waiting for change. While the world just stayed the same
French dance monsters mega-mix it up
The 70's is the zombie of our recent decades.
As formerly heard at Dior and Balenciaga
The track every new girl should practice walking to.
From his album Wander/Wonder
I heard this song this morning in the context of a piece of Hugh Lippe film work
ELECTRO Classique
80kidz is a Japanese electro unit formed in 2006.
You love a superior taste in graphics married to classic techno crescendos don't you!
Hercules And Love Affair...the salvation of New York Dance Music
Carry On Iekeliene Stange!
The deeper it sinks into mix the more deft the vocal tweaking gets
Slow it down a tad: Add a banging baseline and the kids will rampage on the floor


text:
Senate Votes on MTA Bailout and Reform Package
State Capitol Building
Albany, NY 12247
related issues:
Legislation will fundamentally change the way the MTA operates and prevent devastating fare hikes and services cuts
(Albany, NY) The New York State Senate today will vote on the Senate's MTA bailout and reform package that will save straphangers from costly fare hikes and crippling service cuts, while also finally enacting much-needed oversight and accountability to an agency that has demonstrated poor fiscal management and dubious accounting practices. At the Senate's demands, a forensic audit will be conducted by an outside body.
Immediately following the end of session, Senate Majority Leader Malcolm A. Smith, along with members of the Senate, will hold a media availability. That availability will be carried live via satellite, coordinates to be sent soon.
Capitol, Majority Conference Room
Wednesday, May 6th, immediately following session (approximately 1:30 PM)
How a Bill Becomes LawLearn More
Senator has new policy idea
Idea is drafted into a Bill
Bill undergoes committee process
Senate and Assembly pass bill
Bill is signed by Governor


text:
Verified Purchase
Posted by Reviewer1373028 on Mar 10, 2011
My one year old boy loves it.
Posted by Reviewer3211107 on Mar 30, 2011
Healthy Times, Hugga Bear Cookies, Honey Graham, 6.5 oz (182 g) (HTM-32902) 27229
Posted by Reviewer1843845 on Jun 09, 2011
Great for kids
Posted by Reviewer3143745 on Jan 23, 2012
My little boy loved them!I will buy them again for sure!
Posted by Tingeling on Apr 09, 2014
Theese reminds me of the cookies we got when we was kids, yummi! I dont mind buying theese again:)
very good biscuit for my little one
Posted by Reviewer1469586 on Aug 15, 2011
So good biscuit that my baby love it very much
Posted by 5647953489517623935 on May 20, 2014
My kids and I find this quite delicious. We did have a lot of broken biscuits
Taste good
Posted by 5143581158649970136 on May 20, 2016
2nd time to buy it, my son love it. But after delivery, most of the biscuits were broke, it's hard to eat. I always but chip or biscuit from iherb, but they always broke as small piece. Hope can improve the quality of delivery.
Tad too sweet but Kid Likes
Posted by Reviewer1723705 on Jun 10, 2011
My 15-mth-old toddler likes it. Will probably buy again, but personally find it a tad too sweet.
1-10 of 12 total
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text:
Purchasing Tips
You may want to use the following check list, courtesy of Oz-Cover Pty Ltd.
- Will your supplier also arrange lodgement of your building application on your behalf, at no extra cost, to save you the time and hassle involved dealing with Council's red tape?
- Does your supplier use the same thickness of .42 BMT/.47 TCT cladding on the roof and the walls for added strength. TCT (Total Coated Thickness) is the steel thickness including the paint cover while BMT (Base Metal Thickness) is the steel thickness excluding the paint cover.
- Is the roof of the building trafficable i.e. 0.47 roof and correct purlin spacing?
- Are frames made from Hi-Tensile galvanized steel?
- Are the frame connections bolted with substantial connector plates?
- Are wall and roof screws Class 3 and Corrosion protected?
- Is all steel supplied from Australian BlueScope Steel having the BlueScope Steel warranty and offering the full colorbond® colours
- Are hold down bolts included?
- Is P.A. door supplied with proper jambs and entrance lockset?
- Are Flashings for Windows and Roller Doors included?
- Are gutters fitted with appropriate gutter brackets?
- Is the deposit payable less than 20%?
- Will you receive a set of engineers drawings with certificate upon signing agreement?
- Is your supplier a licensed QBSA builder so they can supply, prepare the concrete slab and erect your garage without you having to chase up contractors or insurance etc?
QBCC Act Licence No: 78274 – Click here for more information on the benefits of using a licenced builder.


text:
BETHALTO — In spite of what you may have heard, these colors do run, and it was all for a good cause as more than 275 participants took part in Saturday's Color Dash 5-K run at Trimpe Middle School in Bethalto.
"Every half-mile there was a color station where they got a different color made from corn starch thrown on them," said Bethalto P.E. teacher and event organizer Jason Huhsman. "There were people throwing it on the runners as they went by. Basically they looked like they were completely tie-dyed."
The Color Dash was held to benefit the Bethalto Community School District's Physical Education Department, including the P.E. programs at Bethalto East Primary, Parkside Primary, Meadowbrook Intermediate, Trimpe Middle, and Civic Memorial High School. These schools combined provide P.E. activity to approximately 2,500 students from grades K-12. The Color Dash proceeds will help purchase new P.E. equipment at the schools.
Saturday's event also featured dance, hula-hoop and other contests.
"I found the idea in a P.E. magazine while looking up equipment. I looked at it and thought it would be fun," Huhsman said. "I had seen them being held in different cities around the country, and thought why not give it a try. We've had 5-Ks here before that our P.E. teachers at the middle school put on, and we figured, why not pull the team together and have one big one?"
Stacey Hoffmann of Bethalto is a teacher at Trimpe Middle School who participated in the Color Dash, and she estimated there was no portion of her that did not receive a dousing of color.
"I got it pretty good, it's even down my shirt," Hoffmann said. "It was cool to get all of the colors on us, this was something that was on my bucket list to do, and then it was here in Bethalto and that was even better.
"Everybody seemed to have a blast, there were even a couple of little ones who got out of their strollers at the very end, and they kept putting colors on everybody, and they were running across the field at the very end across the finish line to say they finished it," Hoffmann said.
Hoffmann's 10-year-old daughter Alyssa Hoffmann, a Trimpe Middle School fifth grader, seemed to pick up more yellow color than anything else during the event, but that was OK because "it's one of my favorite colors," Alyssa Hoffmann said. "I heard about it when I was in P.E. at school, and I wanted to do it because it sounded fun and also I wanted to get colored."
Meadowbrook Intermediate School Principal and event organizer Kim Wilks loved the Color Dash idea when she heard about it.
"I thought the idea was awesome, because there are many color runs in St. Louis and some of our kids would probably never be able to participate in something like this," Wilks said. "So we wanted to bring it to our school district and make it a good family day for community involvement.
"One of the goals for our district and for our schools is to make a footprint in our community," Wilks said. "And sometimes in doing that you have to have a little fun like we did today."
The Color Run was held as part of the Bethalto School District's P.E. Alignment Team K-12. The team meets twice a semester to align curriculum and sponsor community events, said Wilks, who is part of the group.
"We decided about four years ago that each school would put on a community event and all schools would help that individual school," Wilks said. "We have an amazing P.E. team in this district and they all help each other and we all support the programs. We are looking at it as a global effort, not just individual schools."
The District 8 P.E. Alignment Team consists of Wilks and Huhsman; David Page, Kristie Ochs, Jeff Ochs, Krista Kuntz, Ty Laux, Mike Parmentier, Jared Reynolds, Angie Parish and Chris Jordan.


text:
2005 Forever Changes the Face of Bordeaux
The 2005 Bordeaux prices reached dizzying heights for some properties. Those who wanted to buy the first growths and wines like Petrus and Cheval Blanc had to fork over a lot of money. Some customers such as myself were priced out of the market for these wines. The good news is that the 2006 Bordeaux prices will probably be much lower. I would advise you to do what I'm doing: Get over it! The wine marketplace is always in a constant flux. In 1961 first growths cost $3.00, people were outraged when Beaulieu Private Reserve doubled in price form $1.00 to $2.00 in the same era. Things change; that's reality. The reality is also that the weather in Bordeaux has historically never been better than it was in 2005, and there is a plethora of great wine, correctly priced. Here are my tasting notes on some of those. Why not compare them to the price of your average vintage of Napa Valley Cabernet? The 2005 Carraudes de Lafite ($55.99) showed some nice cool dark fruit and elegance, but it was still very tight and unyielding at this tasting. Shows fine concentration. The 2005 Clos du Marquis ($49.99) was off the charts and by far the best I've ever tasted! A beautiful thickness of red fruits and sweet tannins, no question a better tasting wine today than Las Cases. It seems to me that with two great wines like these, they blended the first wine to stand the test of time and longevity, because it's hard to believe how much outrageously fine fruit is in this second wine. Sweet red/black fruit with nice round tannins and a powerful finish are in the 2005 Clerc-Milon ($45.99). Never a softy, this is a very solid Clerc that will age very well. With good strong, spicy fruit entry and then grip, the 2005 d'Armailhac ($39.99) is a wine to cellar quite a few years. Showing good, forward red fruit with smoky-earthy hints, the 2005 Haut Bergey Rouge ($29.99) is a well-balanced mid-weight and mid-term wine. The producer of one of Bordeaux greatest whites has turned its red wine program around! The silky blood red fruit of the 2005 Domaine de Chevailier ($51.99) is deep, pure and outrageously attractive. A wine in perfect harmony, balanced with a sweet, long, elegant finish. The 2005 Barde Haut ($36.99) shows very ripe, large red fruit and good brightness. Not overdone, this one's well balanced and all together. Lost in the middle of all the madness of red wine pricing is the outrageous quality of the 2005 Sauternes, a cross in style between the firm acidity and brightness of 2001, and the lush and fat 2003s. If you missed the 2001s, do not miss the 2005s. Prestigious estates of profound quality like 2005 Ch. Suduiraut (375ml $34.99), offering "great thickness and acid insure longevity," are still available at opening prices. The deal of the vintage is once again the "very sweet and incredible honey flavors" featured in the 2005 Ch. Doisy-Vedrines (375ml $17.99). Two new 2005s have arrived and are perfect for your fall festivities: Rosé from neighbors in St-Estèphe: Rosé de Phelan Segur ($8.99) and the Rosé de Calon ($12.99). Very fun wines to serve chilled, these can handle a range of appetizers as well as traditional turkey, so save a few for the bird! Feel free to contact me anytime with questions or advise on the wines of Bordeaux at ex 2723 or email@example.com. Cheers and Go Giants and Niners! —Ralph Sands


text:
[Wednesday Deadline] Lock in your spot NOW! Incredible fear of loss system
- Status Closed
- Budget $250 - $750 USD
Project Description
Click here: [url removed, login to view]
Most companies charge for marketing systems.
or you need to find your own 3rd party system,
or worst... create your own
90% of people have no clue how to do any of that stuff.
If it's too techie, then there's no duplication.
Fortunately, this company has everything you need to see
simple duplication happen online.
The company will automatically send out emails to let your
opt-ins know that they will lose out if they don't take action
in X amount of days.
This is how you get high conversion and put more money in your pockets.
No need to figure out how to set anything up. All you need is the link.
No need to set up autoresponders, contact managemenet system, capturepages.
This has it all!
Sooner you are in the system, the better.
Doesn't cost you to hold a spot.
Click Here: [url removed, login to view]
To Your Success,
Stephen Forte
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- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Personal | Planning | Life Events | Having a Child | What You Need
You've been looking forward to this day for months: the day you bring your new baby home from the hospital. To make sure they're fully prepared, many parents go all out in buying everything they think they might possibly ever need for their baby before this big day.
You can save some money, however, by scaling back. Here's a handy checklist of the most important things that you absolutely must have on that first day, and the things you can probably hold off on for a little while:
Save even more money by shopping for used clothes, furniture and equipment. Many children's consignment shops offer high-quality clothing, furniture, toys, etc., at a fraction of retail prices. However, use caution with car seats, cribs, high chairs and strollers, as updated safety standards may render used ones obsolete.
Forgot User ID?
Not signed up? Enroll now
Digital Banking
Mobile Banking
An identity theft scheme targeting financial accounts is circulating through text messages, social media platforms and/or by telephone. This scheme is an attempt to get the username, password, Social Security number, or other sensitive information from account holders.
© 2017 First Tennessee Bank
Banking products and services are provided by First Tennessee Bank National Association. Member FDIC. Equal Housing Lender.


text:
Aonang Beach Home
Find Hotel Rates
Recent Searches
Wego searches multiple travel sites so you can find and compare the best rates.
Aonang Beach Home Hotel Reviews
Based on reviews from across the web.
Aonang Beach Home Hotel Details
Check-in: 2 PM
Check-out: 11 AM
Ideally located in the prime touristic area of Ao Nang, Aonang Beach Home promises a relaxing and wonderful visit. Featuring a complete list of amenities, guests will find their stay at the property a comfortable one. Take advantage of the hotel's smoking area, salon, family room, restaurant, safety deposit boxes. Comfortable guestrooms ensure a good night's sleep with some rooms featuring facilities such as satellite/cable TV, air conditioning, refrigerator, balcony/terrace, internet access – wireless (complimentary). The hotel offers various recreational opportunities. A welcoming atmosphere and excellent service are what you can expect during your stay at Aonang Beach Home.


text:
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text:
Looking for Redirect mobile website php script Freelancers or Jobs?
Need help with Redirect mobile website php script? Hire a freelancer today! Do you specialise in Redirect mobile website php script? Use your Redirect mobile website php script skills and start making money online today! Freelancer is the largest marketplace for jobs in the world. There are currently 17,764 jobs waiting for you to start work on!View Top 6 Graphic Designers View Top 6 Web Developers
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|Price (USD)
|Price (USD)
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|I need a wordpress expert. Im using a external mobile site for my wordpress site (dudamobile) and some pages dont work with dudamobile platform (pages with java script). The problem is that there is a redirect code implemented in [url removed, login to view] that will redirect all mobile users to dudamobile (our mobile version) but we need to disable/erase this redirect code in the header for s...
|PHP, Website Design, Graphic Design, WordPress, HTML
|Feb 20, 2017
|Feb 20, 20175d 15h
|Manually 301 Redirect Blog Posts
|I am trying to redirect manually redirect 60 blog post from two different wordpress blogs to a new wordpress blog on a different domain. I know there are some 301 redirect plugins, but I think a manual setup would work better.
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|Hello, I need a mod rewrite command in htacess to redirect my visitors that have specific keywords in link to related links on my site. An example: A visitor comes from a site that has in link: house, we will redirect to [url removed, login to view] and so on. I will add up to 120 redirects. Thanks and waiting your bid!
|PHP, Website Design, Graphic Design, Blog Install
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|CSS WP JOB START NOW LONG RUN TONIGHT! fix toolbar WP , checkbox function in signup admin email notification, redirect login ,private area user role functions
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|The new setup is completely the same (only different domains and folder names). But if I go to the base url [url removed, login to view] I will always be redirect to the new domain. Things I have already done/tried: Changed the base_urls in core_config_data Cleared var Cleared session table Reindex Checked htaccess for redirects Checked [url removed, login to vi...
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Members of the Anderson County High School football team celebrated their state runner-up season with the annual team awards banquet Sunday at the high school. Seth Carmichael and Ethan Kelly were named Most Valuable on offense while Travis Phillips was selected as Most Valuable on Defense. Bill Rose and Chris Fitzpatrick were selected as Most Valuable on Special Teams. All are seniors.
Anderson County got 18 points from Jay Smith, while Ross Cox and Lowell Gordon added 14 and 13, respectively, as the Bearcats routed visiting Washington County, 74-55, Saturday night.
Anderson trailed only once at 3-2 and took total control of the game with a 12-0 run late in the second quarter. A 17-2 outburst over 3:14 of the third quarter turned the game into a rout. Anderson led 53-38 after the uprising.
There is a reason they are called free.
They are those unguarded shots, taken at the shooter's leisure, just 15 feet from the basket. They might be called free throws, but they were costly Friday night as Owen County dealt Anderson County its first home loss of the season – and second straight defeat – with a 59-50 decision in overtime.
To be sure, the box score would show that Owen was statistically no better than Anderson, hitting 16-of-32 charity tosses to the Bearcats' 8-of-16. That's 50 percent for either team.
Anderson's girls steam-rolled host Spencer County, 90-12, Friday to run their 30th District winning streak to 19 games.
Anderson took care of business early to run its record to 14-4. The Lady Bearcats led 20-4 after a quarter, then outscored Spencer 29-2 in the second frame.
Ten different Anderson players scored, including five in double figures. Eriel McKee led Adnerson with 20 points.
Spencer fell to 4-11.
The teams will meet again in the first round of the 30th District Tournament in late February.
It only looked like Eriel McKee was a one-girl wrecking crew against Mercer County last Tuesday.
It is true that the Anderson County sophomore ripped the visiting Titans for 22 points and pulled down 14 rebounds. It is also true she blocked five shots as Anderson rolled to a 58-32 win. And it was not much of an exaggeration when Anderson coach Tony Kays just chuckled and said, "Eriel was just off the charts in every category tonight."
Anderson County will get an opportunity to clinch the top seed in the 30th District Tournament when they travel to Spencer County on Tuesday, Jan. 24.
Anderson is 2-0 in district play and will take the top spot in the tournament with a victory, no matter what else happens. At press time, Spencer had not played any district games and could win the top seed by winning all of its district battles.
This was one time I wish I had missed the press conference.
It is usually a perk when I have the opportunity to work a major college athletic event. It's a time when you get to talk with those highly-paid coaches and some players whose earnings will someday make those coaches comparative paupers.
And, being in the newspaper business, it is always a chance to hobnob with the local – and occasionally the national – heavyweights in the field.
I won't lie. It's a lot of fun.
A cash reward is being offered for the woman consider the prosecution's star witness in the trial of a Lawrenceburg man charged with stomping a puppy to death before setting it ablaze.
Elizabeth "Beth" Dennis, 34, was the girlfriend of Paul "Doobie" Dearinger when he allegedly killed the puppy in October, 2010.
His trial is scheduled to begin this Wednesday, and the city police and sheriff's office have been actively trying to serve Dennis a subpoena for her to testify, along with a felony warrant for flagrant non-support.
Owen County's Sawyer Williams scored 22 points and pulled down 19 rebounds as the Rebels slipped past host Anderson County, 59-50 in overtime Friday night.
Williams, ranked as high as the Eighth Region's second-best player in the pre-season, scored 18 of his points after halftime. Williams, a 6-foot-7 senior, hit 12-of-20 free throws, but hit 8-of-12 in the fourth quarter and overtime.
Copyright © 2017
The Anderson News is your source for local news, sports, events, and information in Lawrenceburg, KY and the surrounding area.


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Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff
DOI: 10.1186/ar1965
© Neuwirth et al.; licensee BioMed Central Ltd. 2006
Received: 10 October 2005
Accepted: 24 April 2006
Published: 23 May 2006
Degeneration of the rotator cuff is often associated with inflammation of the subacromial bursa and focal mineralization of the supraspinatus tendon. Portions of the supraspinatus tendon distant from the insertion site could transform into fibrous cartilage, causing rotator-cuff tears owing to mechanical instability. Indirect evidence is presented to link this pathology to ectopic production and secretion of bioactive bone morphogenetic proteins (BMPs) from sites within the subacromial bursa. Surgically removed specimens of subacromial bursa tissue from patients with chronic tears of the rotator cuff were analyzed by immunohistochemistry and reverse transcription-PCR. Bioactive BMP was detected in bursa extracts by a bioassay based on induction of alkaline phosphatase in the osteogenic/myogenic cell line C2C12. Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue. The bioassay of C2C12 cells revealed amounts of active BMP high enough to induce osteogenic cell types, and blocking BMP with specific antibodies or soluble BMP receptors Alk-3 and Alk-6 abolished the inductive properties of the extract. Sufficient information was gathered to explain how ectopic expression of BMP might induce tissue transformation into ectopic bone/cartilage and, therefore, promote structural degeneration of the rotator cuff. Early surgical removal of the subacromial bursa might present an option to interrupt disease progression.
Alterations to the rotator cuff owing to chronic degenerative and traumatic lesions are not only frequently diagnosed in the elderly, but are also seen as a result of occupational or sports activities. It is also widely accepted that cuff ruptures attributed to an accident mostly occur in patients suffering from asymptomatic degenerative lesions of the tendon.
Chronic degeneration of the rotator cuff frequently presents as an 'impingement syndrome', with painful restriction of joint mobility. X-rays can reveal dense clouds within the tendon, establishing the diagnosis of 'tendinosis calcarea' as an additional pathologic trait. Ultrasound or magnetic resonance imaging usually demonstrates an enlarged subacromial bursa adjacent to the rotator-cuff lesion. Surgical treatment focuses on anatomic and functional reconstruction. Nevertheless, the results are often poor. Even after debridement of the torn tendon, followed by suturing or osseous reattachment, the tissue does not better: does not re-adjust to the functional and mechanical demands. As a result, nearly two-thirds of surgically reconstructed rotator cuffs experience a re-rupture [1, 2]. This clinical dilemma emphasizes that the underlying pathomechanisms involving the rotator-cuff tendon and subacromial bursa are not yet understood.
One of the pathologic hallmarks is inflammation, with consequent hypertrophy of the subacromial bursa [3, 4]. Hypertrophy of the bursa is regarded as one of the causes of the chondroid transformation of the supraspinatus tendon because the expanded bursa tissue can act on the tendon and surrounding tissues. Expansion of the bursa, however, does not explain calcification of the tendon. Therefore, tendinosis calcarea is classified as a separate disease entity, although quite frequently co-existing with an impingement syndrome attributable to rotator-cuff tears [5–8].
Here, we present evidence that chronic degeneration of the rotator cuff is associated with inflammation-related induction of bone morphogenetic protein (BMP) activity in the joint. The deposition and activation of significant quantities of BMP could, in part, explain the observed rotator-cuff pathologies, together with inflammation-induced proliferation of connective tissue. BMP might induce differentiation of competent cell types, such as mesenchymal precursors, tendon cells, and other soft tissue cells, into osteochondral lineages, to form ectopic populations of (fibro-) cartilage and mineralized tissues. To support this hypothesis, experiments were carried out to define the level of BMP and its activity within the affected subacromial bursa.
Materials and methods
Subacromial bursa was harvested from a total of 29 patients (age range, 36–75 years; median age, 57 ± 9.8 years; normal distribution (Kolmogorov-Smirnov) during surgical interventions to address rotator-cuff tears, with patient consent and institutional approval (approval #0981-10/02 from the Ethics Committee of the Medical Faculty at the University of Jena, Jena, Germany). Two patients were acute trauma cases who received emergency shoulder surgery and served as donors of 'normal' bursa tissue. The tissue was collected in an oriented fashion and immediately frozen using dry ice. Aliquots from segments close to the acromion, the medial portion, the basal portion, and close to the tendon (containing tendineus tissue) were excised using a 2.5-mm tissue punch, placed into an RNA extraction solution (TRIzol™ reagent; Life Technologies, Invitrogen, Carlsbad, CA, USA), and stored at -80°C. The deep-frozen tissue was also stored at -80°C before use.
Bone morphogenetic protein extraction
Deep-frozen tissue was placed into 4 M guanidinium/HCl (approximately 1 ml/100 mg tissue), which was supplemented with protease inhibitors (0.1 mM phenylmethanesulfonylfluoride, 0.1 mM N-ethylmaleinimide, and 5 mM ethylendiaminetetraacetic acid). Extraction was performed overnight at 4°C. The enrichment of BMP followed established procedures. The extract was centrifuged at 10,000 rpm in a microvial centrifuge and then exhaustively dialyzed against column buffer (0.05 M Na-acetate and 30% isopropanol; pH 5.0). The clear solution was placed on top of a small bed of MonoS beads (GE Healthcare, Munich, Germany) in a 10 ml syringe and allowed to flow by gravity. The beads were washed with column buffer, and the bound protein was stepwise eluted with 0.1 M, 0.5 M, and 1 M NaCl in column buffer. Typically, most of the BMP activity was detected in the 0.5 M NaCl fraction. The eluates were concentrated by lyophilization and dialyzed against PBS before being applied to the cell culture.
Cell culture
The osteogenic mouse precursor cell line C2C12 (purchase number CRL-1772) was purchased from American Type Culture Collection (ATCC) (LGC Promochem GmbH, Germany) and routinely cultured at low density in Dulbecco's' modified Eagle's medium supplemented with 10% fetal calf serum, with serial passages by trypsination. The serum was pretested to ensure that it contained as little as possible osteogenic activity towards C2C12 [9]. For testing the extract, 1,000 cells/well were placed into 96-well microplates and allowed to adhere overnight. Medium was then exchanged with medium containing defined amounts of extract respectively recombinant human BMP-2 [10] and BMP-7 (Stryker Biotech, Hopkinton, MA, USA) standards, plus 10 μg/ml vitamin C and 20 nM vitamin D (cholecalciferol, Sigma-Aldrich, Munich, Germany). After 5 days of cultivation, the medium was removed and cells were washed once with PBS before determination of alkaline phosphatase (AP) activity, as a marker for osteogenic activation. To detect localized BMP activity in bursa tissue, frozen sections (10 μm) were dried onto sterile glass slides and 10,000 C2C12 cells were seeded onto each slide. Following 5 days of incubation, the cells were fixed with 4% paraformaldehyde in PBS and submitted to AP detection, as described below.
Alkaline phosphatase
AP activity in 96-well C2C12 cultures was detected and quantified using an AP chemiluminescence detection kit (Roche Diagnostics GmbH, Mannheim, Germany). As a calibration, purified AP (activity 35,820 units/ml; EMD Biosciences, VWR DEUTSCHLAND GMBH, Darmstadt, Germany) was serially diluted and allowed to react with the kit in parallel wells without cells. Detection of bioluminescence was performed in a FluorS MultiImager (Bio-Rad Munich, Germany). Enzyme activity was evaluated against a calibration curve in the activity range from 1791 down to 17.91 μU (regression coefficient, >0.9) with purified bone AP. Significance (P) was calculated with a paired t test, comparing quadruplicates from the control group with each treatment group. For qualitative detection of AP activity in histological sections, frozen sections or paraffin-embedded sections (after deparaffination) were incubated with an NBT/BCIP detection kit (Roche Diagnostics GmbH, Mannheim, Germany), forming a dark blue precipitate. Levamisole (0.5 mM) was used, as directed by the manufacturer, to differentiate bone AP from other isoenzymes.
RNA and reverse transcription-PCR
Primers for RT-PCR
RT-PCR product (base pairs)
Annealing temperature
The real-time quantitative RT-PCR reactions were carried out, using an iCycler 'iQ Real-Time PCR' instrument (Bio-Rad Munich, Germany) and an 'IQ SYBR Green Supermix' (Bio-Rad Munich, Germany), with primers that specifically amplified the transcripts of the genes of interest. The primers used for qRT-PCR were the same as those used for RT-PCR, with the exception of GAPDH, type II collagen, and tumor growth factor (TGF)-β mRNA-specific primer pairs. These were as follows (upstream and downstream primers, and expected product size (base pairs (bp))):for GAPDH, 5'-CATCACTGCCACCCAGAAGA-3', 5'-CCTGCTTCACCACCTTCTTG-3', and 254 bp (NCBI: NM_000660); for type II collagen, 5'-CAACACTGCCAACGTCCAGAT-3', 5'-CTGCTTCGTCCAGATAGGCAAT-3' [12], and 107 bp; for TGF-β, 5'-CGGCAGCTGTACATTGACTT-3', 5'-AGCGCACGATCATGTTGGAC-3', and 270 bp [NCBI: NM_002046]
Frozen sections (5 μm) were obtained from the deep-frozen bursae and stained by indirect immunofluorescence procedures. Mouse monoclonal antibodies were chosen for BMP-2/4 (final concentration, 2.5 μg/ml; MAB 355, R&D Systems,) and for BMP-7 (final concentration, 40 μg/ml; MAB 3541, R&D Systems, Wiesbaden.Nordenstadt, Germany). Parallel sections were stained to obtain information on approximate co-localization and BMP activity on application to C2C12 cells (see above).
Statistical analysis and graphs
Statistical calculations were performed using SigmaStat 3.0 (SPSS GmbH, Munich, Germany). The graphs were made with SigmaPlot 8.0 (SPSS).
Immunohistology and histochemistry
Expression of mRNA for bone morphogenetic protein, matrix proteins, and cytokines
mRNA for growth factors of the TGF-β superfamily was found in all samples (some stratification was typical), with the following order of magnitude: TGF-β (in a ratio to GAPDH of 0.3) > BMP-7 (in a ratio to GAPDH of 0.03) > BMP-2 (in a ratio to GAPDH of 0.001). BMP-2 did not show preferential sublocation in its expression; however, BMP-7 mRNA in the acromial portion of the diseased bursa was approximately two orders of magnitude higher than in the healthy samples (in a ratio to GAPDH of 0.09 compared with 0.0009, respectively), representing the largest difference in growth factor expression between diseased and healthy tissues.
As examples of alternative tissue growth factors, fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF) mRNA was also present and helps to explain the proliferation of the bursa into granulation tissue, with loose connective tissue and blood vessels amply present. However, FGF-2 mRNA levels were low throughout the tissue – the ratio of FGF-2 mRNA to GAPDH mRNA was about 10 times lower than the ratio of BMP mRNA to GAPDH mRNA- and was not preferentially localized within the bursa. Of the family of inflammatory cytokines, we tested for interleukin (IL)-1 and tumor necrosis factor (TNFα. As in the present example, typically IL-1β mRNA was not prominent, whereas TNF-α mRNA was always expressed, in particular within the top portion of the bursa. Figure 5b shows a representative cross-sectional mRNA analysis from 14 patients.
Biogenic bone morphogenetic protein activity
We decided on a bioassay for differentiation rather than directly determining quantities of specific BMPs. Although measuring BMP concentrations is an exact method, no information is given on the bioactivity, because molecules might exist in an inactive pro-form, partially degraded or denatured, or in mixtures that cancel out effects on differentiation. The C2C12 cell line is an established detector of BMP type I receptor-related BMP activity owing to its induction of AP [9]. On the basis of this receptor constellation, BMP-2 and BMP-4 should be initiators of osteogenic differentiation. However, we also found, although to a lesser degree, that BMP-7 could induce AP within these cells. In the extract, we found that the BMP equivalent induced 380 ± 135 μU AP/100 mg of bursa tissue, with the medium control displaying 175 ± 51 μU AP/100 mg of bursa tissue (P = 0.0163). By contrast, under the same conditions, 25 ng/ml recombinant BMP-2 induced 460 ± 154 μU AP/100 mg of bursa tissue (P = 0.0021) and 50 ng/ml of recombinant BMP-7 induced 430 ± 111 μU AP/100 mg of bursa tissue (P = 0.0058). BMP activity could be completely abolished by incubation with neutralizing antibodies against BMP-2 and BMP-7, in addition to incubation with the soluble BMP receptors Alk-3 and Alk-6 (not shown).
Degenerative alterations to the rotator cuff are generally regarded as the consequence of mechanical abutment, undefined 'rheumatoid' inflammation, or previous accident. Although these causes could describe possible etiologies, they do not completely explain the cellular and molecular alterations seen in and around the rotator cuff, such as chondrogenic transformation and ectopic mineralization of the tendon tissue. With the present set of data, an additional perspective towards a causative explanation is given: chronic activation of morphogenetic factors (BMP-2, BMP-7, TGF-β, VEGF, and FGF) that might actively contribute to the rise of mechanically incompetent and (because of the mineral deposits) chronically irritating tissue components. The differential expression of BMP-2 and BMP-7, with BMP-7 expressed in a decreasing gradient from acromion to tendon, suggests a distinct contribution of BMP-7 to the disease process. Additional expression of inflammatory cytokines (IL-1β and TNF-α) might serve in propagating local inflammation and tissue destruction.
In bursa samples from patients with ruptures of the rotator cuff, expression of collagen types I and III was enhanced compared with normal controls [16]. In addition, enhanced expression of IL-1β, both secreted and cell-bound IL-1 receptor antagonists, and VEGF have been demonstrated [4, 17, 18]. Participation of the bursa in the disease progression of the rotator cuff has also been shown in animal experiments with rabbits [19] and chickens [20]. Specifically, chemical induction of a bursitis-induced chondrogenic metaplasia of the supraspinatus insertion site [21]. These reports are not only in line with our findings, but also strongly suggest significant influence of molecular events within the subacromial bursa on the fate of the underlying supraspinatus tissue.
Unfortunately, there is no recent literature on the histology of the normal bursa. Organ material from tumor-related and joint-replacement surgery was available but always showed signs of degeneration, depending on the primary disease, and was thus unrepresentative of a normal situation. Nonetheless, the presence of bioactive BMP in itself supports the hypothesis of its role in induced chondrogenesis, irrespective of whether and, if so, how much it is expressed in normal tissue.
The amounts of BMP we detected are quite significant. Although direct estimates are hard to compare, the mid-ng quantities/mg of bursa tissue represent an overwhelmingly strong potential for morphogenetic signaling. In particular, the in-situ transformation that was achieved by placing the detector cell line C2C12 onto tissue slices reveals the effectiveness of the deposited BMP within the bursa. BMP detected within the cell and extracellular matrix of blood vessels might have been transported there through the bloodstream. However, the microanatomic distribution of immunohistological signals and the results from the PCR analysis strongly suggest local production rather than introduction from outside the bursa. Because we could block the differentiation signal by incubating the extracts with anti-BMP antibodies or soluble BMP receptors, a dominant role of BMPs in activating tissue transdifferentiation can be assumed, although a contribution of other growth factors cannot be excluded.
Because of the normal function of the bursa, the BMP might reach the tendon tissue through anatomic secretion pathways from the glandular elements within the bursa. Unfortunately, too little is reported in the literature about the secretary activity of this normally rather inconspicuous layer of tissue underneath the acromion. It is obvious, however, that there was significant cartilage differentiation, with RNA levels for cartilage collagen types II and X at quite significant levels in parts of the patients' tissue. Collagen to GAPDH ratios of >0.1, as detected here, are usually found in normal articular, mineralizing, and osteoarthritic tissue [22, 23]. In addition, studies performed in the rat support our observation of long-term preservation of cartilage-related gene expression in the supraspinatus [24].
There is some information on the production and role of BMP in adult soft tissue. BMP is produced by gingival and periodontal fibroblasts [25], megakaryocytes and platelets [26], cells supporting egg maturation [27, 28], the kidney [29], and also connective tissue tumor cells. More importantly, arthritic synovial membranes have been shown to express BMP-2 and BMP-6 and can influence cell turnover [30]. Early studies showed that BMP induces tissue transdifferentiation of tenocytes into chondrocytes in vitro [31] and, more recently, studies showed BMP-induced transdifferentiation of kidney fibroblasts into epithelial cells [32]. Our finding in itself is not unexpected, retrospectively, but so far, to our knowledge, no attempts have been made to directly link the 'shoulder syndrome' to ectopic overexpression of BMP. Our approach using AP differentiation within the C2C12 cell line gave us a tool to explore primary features of the BMP deposited within the bursa. However, to describe the entire pathologic pathway from soft tissue to mineral deposits and fiber cartilage, more experiments are needed using chondrocytes and primary mesenchymal precursor cells in vitro or with exogenous deposits of defined BMP in animals.
In the absence of pharmacologic strategies to counteract untoward BMP activity, only surgical intervention is an option for curative approaches to preventing eventually dramatic outcomes, such as in cases of ossification of the rotator cuff [33]. Complete excision of the subacromial bursa either before acute rupture or during restorative surgery of torn ligaments or the tendon might represent the only option we currently have.
= alkaline phosphatase
= bone morphogenetic protein
- ΔCt:
= threshold cycle number for amplified cDNA
= fibroblast growth factor
= glyceroaldehydephosphate dehydrogenase
= interleukin
= phosphate-buffered saline
reverse transcription-PCR
= tumor growth factor
tumor necrosis factor
= vascular endothelial growth factor.
The excellent technical assistance of Christine Mollenhauer and Cordula Mueller is gratefully acknowledged. This work was supported, in part, by a grant from the Interdisciplinary Center for Medical Research at the University of Jena (# TP 2.7), a grant from the Deutsche Forschungsgemeinschaft (AU 56/6-1), and both a research fellowship for MA and a grant from the German Ministry of Science and Technology (0313177).
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- Ivanovski S, Li H, Haase HR, Bartold PM: Expression of bone associated macromolecules by gingival and periodontal ligament fibroblasts. J Periodontal Res. 2001, 36: 131-141. 10.1034/j.1600-0765.2001.360301.x.View ArticlePubMedGoogle Scholar
- Sipe JB, Zhang J, Waits C, Skikne B, Garimella R, Anderson HC: Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Bone. 2004, 35: 1316-1322. 10.1016/j.bone.2004.08.020.View ArticlePubMedGoogle Scholar
- Pierre A, Pisselet C, Dupont J, Mandon-Pepin B, Monniaux D, Monget P, Fabre S: Molecular basis of bone morphogenetic protein-4 inhibitory action on progesterone secretion by ovine granulosa cells. J Mol Endocrinol. 2004, 33: 805-817. 10.1677/jme.1.01545.View ArticlePubMedGoogle Scholar
- Glister C, Kemp CF, Knight PG: Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin. Reproduction. 2004, 127: 239-254. 10.1530/rep.1.00090.View ArticlePubMedGoogle Scholar
- Ozkaynak E, Schnegelsberg PN, Oppermann H: Murine osteogenic protein (OP-1): high levels of mRNA in kidney. Biochem Biophys Res Commun. 1991, 179: 116-123. 10.1016/0006-291X(91)91342-A.View ArticlePubMedGoogle Scholar
- Lories RJ, Derese I, Ceuppens JL, Luyten FP: Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum. 2003, 48: 2807-2818. 10.1002/art.11389.View ArticlePubMedGoogle Scholar
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Smithsonian Staff Photo
Four thousand Smithsonian staff stood on the National Mall to pose for a photograph in the shape of the Institution's starburst logo. You can see additional images on the Smithsonian's website. Photo: Dane Penland, Smithsonian Institution
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Ghost Stories
Edited by Peter Washington
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Ghost Stories by Peter Washington
Book DescriptionA new anthology of classic ghost stories the second volume in the beautiful and collectible Pocket Classics format. The chilling classic stories gathered here offer a remarkable variety of approaches to the theme of haunting. Revenge comes from beyond the grave in Robert Louis Stevenson s The Body-Snatcher, while visions of the dead come between the living in Henry James s The Friends of the Friends. P. G. Wodehouse gives us a farcical take on the haunted house in Honeysuckle Cottage, and in L. P. Hartley s W.S., a writer is fatally stalked by his own aggrieved creation. Here are ghosts of every stripe and intent in stories from writers as varied as Elizabeth Bowen and Jorge Luis Borges, Eudora Welty and Vladimir Nabokov, Ray Bradbury and Edith Wharton, among others. In the hands of these masters, the ghost story ranges far beyond mere horror to encompass comedy and tragedy, pathos and drama, and even a touch of poetry."
Buy Ghost Stories book by Peter Washington from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780307269249
(183mm x 124mm x 30mm)
Pages: 407
Imprint: Random House USA Inc
Publisher: Random House USA Inc
Country of Publication: India
Books By Author Peter Washington
Detective Stories, Hardback (August 2009)
A glorious collection of some of the best sleuths in the business. Including creators such as Poe and Conan Doyle to Hammet, Christie, Chandler, Rendell and Rankin. Perfect gift edition.
Russian Poets, Hardback (May 2009)
Ranging in extremes from the melting tenderness of unrequited love to the bitter comedy of political chaos, this collection of poems covering two centuries includes work by Lermontov, Tyutchev, Fet, Annensky,Mayakovsky, Bely, Mandelstam, Akhmatova, Tsvetaeva, Pasternak, Brodsky and others less celebrated but no less extraordinary.
Rumi, Hardback (September 2006)
This volume draws on a wide variety of translations--from the early 20th century to the present--of Rumi's deeply moving, sensually vibrant poetry.
Rumi Poems, Paperback (June 2006)» View all books by Peter Washington
It is often said that Rumi (aka Jalal al-Din, 1207-73) is the most popular poet in the United States. The main key to Rumi's success is the spiritual appeal of his work. It combines lyrical beauty with philosophical profundity, a sense of rapture and an acute awareness of human suffering in ways which speak directly to contemporary audiences.
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Author Biography - Peter Washington
Peter Washington is the editor of many of the Everyman's Library Pocket Poets, including "Love Poems," and is the author of Madame Blavatsky's "Baboon: A History of the Mystics," "Mediums," and "Misfits Who Brought Spiritualism to America."
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Can someone help me with this?
The measurements, cc and ml, are apples and oranges.
ml measures capacity
cc measures volume
Yet they appear to be interchangeable. Are they equivalent?
The prescription says:
bottle contains 22.5 ml
Give 1.8 cc every day for 21 days.
Except, if they are interchangeable, that's only 12.5 doses.
And I did only get 12 doses from the bottle.
Can someone explain? And can you also explain why they can't be consistent - ml or cc?
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One location which featured in the Some Mothers Do 'Ave 'Em Christmas special Jessica's First Christmas (1974) was St Peter and St Paul's Church, Runham, Norfolk - http://www.norfolkchurches.co.uk/runham/runham.htm
Hello do you know wherethe locations are if so please tell me so i can go round the places thanks
One location which featured in the Some Mothers Do 'Ave 'Em Christmas special Jessica's First Christmas (1974) was St Peter and St Paul's Church, Runham, Norfolk - http://www.norfolkchurches.co.uk/runham/runham.htm
I have written below some location information about the Some Mothers Do 'Ave 'Em episode Cliffhanger.
Filming of the cliff scenes took place at Durlstone Point, near Swanage, Dorset, and Dancing Ledge, near Seacombe Cliff, Langton Matravers, between the 7th and 11th of August, with the cast and crew staying at the Richmond Hotel, Swanage.
I found the above information in the following Book - http://www.amazon.co.uk/Some-Mothers...08/ref=sr_1_1?
One I recall was one hilarious episode where Frank is on roller skates and goes down the ramp at Edmonton green shopping centre, acroos the road from Lower Edmonton station, as I recall he goes through a window in a babycare shop and ends up in a cot!
from the book "some mothers do ave em " by richard webber "the job interview" the shop where frank has his interview is 126 high street ,herne bay kent
"have a break take a husband" the stations are windsor riverside and herne bay the hotel the spencers stay at is in central parade ,herne bay
"cliffhanger" durstone point, swanage and dancing ledge,seacombe cliff, langton matravers both in dorset
"fathers clinic" twyford zoo,leicester, the roller skating is at picketts lock leisure centre ,enfield ,north london and right at the end the baby care shop that frank roller skates into is in chiswick high road, west london
apparently a lot of locations for series 3 were in bedford ,in "king of the road" at the end where frank causes the car crash you can see a sign for maitland street
"learning to fly" christmas special cranfield airport ,bedfordshire
my own findings
"the psychiatrist" at the end frank is buried in the sand at mulberry parade,west drayton ,middx
"fathers clinic" frank roller skates between the mini and the capri in princes way ,wimbledon,south london
does any one know any of the locations for the christmas 1975 episode "learning to drive"
Last edited by eric1; 28-01-13 at 01:24 PM.
what is the location for the house in the episode from moving house does anyone one know?
what is the location for the house in the episode from moving house does anyone one know?
Does anyone know the location for the episode Fathers Clinic? I mean outside the clinic itself, where there is a Patisserie, as seen at the beginning here, where Frank gets picked up by "Charles"
Does anyone know the locations for the 1975 chritmas episode "learning to drive" when frank is taking driving lessons and his driving test?.
"learning to drive" christmas 1975 episode frank is having his driving lesson in the white mini where he is overtaken by the woman on a bike is in west side common, wimbledon ,south london, he then turns left onto the runway and nearly has the plane land on top of him (no airfield here!) the following scenes of frank chasing after the runaway mini look very much like wimbledon does anyone know where?


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It's a disturbing statistic for the Hoosier State.
The report was just released by the Governors Highway Safety Association. It tracked the number of fatal accidents during the first half of last year. Every state was tracked and at the top of the list was
The report states that from January 2012 until June 2012,
The report showed that during that same time period in 2011,
It is illegal for everyone in
Indiana State Police Sergeant Ron Galaviz says he suspects that texting was a big factor.
Other top states in that report include
Drugs and alcohol are also believed to be responsible for those increases in deaths.
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The overall goal of the center is to identify genes or genetic mechanisms that cause or contribute to an individual's susceptibility to Parkinson Disease (PD) and to translate these discoveries into early detection of risk or disease, as well as provide therapeutic targets for PD. Our long-term goals include improving therapy for patients by providing important genes, genetic mechanisms and pathways that may be useful to target with drug treatment or other intervention to slow the disease. Project 1 "Identification of rare variants (RV) in PD through whole exome sequencing (WES)" continues our work from the previous year in at total of 1000 PD patients and 1000 controls. The number of genes which have reached genome-wide significance through genome wide association studies (GWAS) remains small and with small effect. This has led to the hypothesis that there is a missing genetic component. The most likely candidate for this missing "hereditability" has been suggested to be rare variants. Pathway analyses and gene network analyses will be included with more traditional frequency analyses. Project 2 " Long ncRNAs as epigenomic modulators and CSF biomarkers in PD" brings an exciting new area of research to PD. Recent RNA sequencing studies have shown that a large proportion of RNA produced by the cell comes from DNA sequence that does not code for protein (ncRNA). Recent work has shown an important role in the regulation of gene expression by ncRNAs in neurological disease. This project seeks to identify key ncRNAs that contribute to the etiology of PD and could serve as biomarkers of disease in CSF. Project 3 "Vitamin D concentration, genetic modifiers, and PD" is a study of the pharmacogenetics of Vitamin D (ViD). Studies have suggested that low ViD is a risk factor for PD. This study seeks to confirm this in a large dataset, and define the gene-ViD interactions that will be necessary if it is to become preventive therapy. The Center has 4 cores: (A) Administrative with Education and Community functions (B) Clinical Resource Core, (C) Statistical Analysis and Bioinformatics Core and (D) a new and innovative core, the Disease IVIodeling Core using yeast, zebrafish and induced pluripotent stem cells. PROJECT 1 Principal Investigator: Jeffery M. Vance, MD, PhD Title: Identification of Rare Variants in PD through Whole Exome Sequencing Description (provided by applicant): Genetic studies in Parkinson Disease (PD) have been a major tool fueling the tremendous growth in research. However, there is increasing realization that common variations (MAF >5%) alone are not responsible for the genetic contribution to risk for developing PD and many other complex disorders. One of the alternative hypothesis for this missing genetic contribution are rare variants. Over the past year we initiated one of the first whole exome sequencing (WES) projects for Parkinson disease to search for rare variants contributing to PD. This project continues this work, incorporates our recent work on pathways into our analyses, and will provide information on the pathways and function of the genes discovered.
Specific Aim 1 identifies an initial set of rare variants and additional SNPs in a discovery set of 500 Parkinson Disease patients and 500 controls for testing in our replication dataset in Specific Aim 3a.
Specific Aim 2 utilizes a large Amish pedigree to look for rare variants using WES, targeted capture and potentially whole genome sequencing. The Amish present a group of individuals with both a relatively uniform environmental exposure history and increased genetic homogeneity. Linkage analysis reveals a strong locus on chromosome 9 In several branches of the pedigree, and additional loci on other chromosomes. This is thus a good model for PD in the outbred population.
In Specific Aim 3 we will test the top 200 genes and/or variants from our discovery dataset in an additional 500 cases and 500 controls. To accomplish this efficiently we will create a targeted capture for next generation sequencing. Analyses of this verification datasets will include multiple subsets of the data including by variant, variants within a gene "cluster", pathway analyses, gene networks of interest such as mitochondrial nuclear genes and AAO differences. In order to improve information on pathways and also evaluate the identified genes and their relationship to other known PD genes, we will examine differentially expression using silencing and other interventional techniques for the candidate genes in three different biological systems through Core D: yeast, zebrafish and induced pluripotent stem cells derived from PD patients and controls.
|Alcalay, Roy N; Caccappolo, Elise; Mejia-Santana, Helen et al. (2014) Cognitive and motor function in long-duration PARKIN-associated Parkinson disease. JAMA Neurol 71:62-7
|Nuytemans, Karen; Inchausti, Vanessa; Beecham, Gary W et al. (2014) Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Mov Disord 29:827-30
|Nalls, Mike A; Pankratz, Nathan; Lill, Christina M et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 46:989-93
|Huang, Anhui; Martin, Eden R; Vance, Jeffery M et al. (2014) Detecting genetic interactions in pathway-based genome-wide association studies. Genet Epidemiol 38:300-9
|Wang, Liyong; Nuytemans, Karen; Bademci, Guney et al. (2013) High-resolution survey in familial Parkinson disease genes reveals multiple independent copy number variation events in PARK2. Hum Mutat 34:1071-4
|Nuytemans, Karen; Bademci, Guney; Inchausti, Vanessa et al. (2013) Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease. Neurology 80:982-9
|Hedges, Dale J; Guettouche, Toumy; Yang, Shan et al. (2011) Comparison of three targeted enrichment strategies on the SOLiD sequencing platform. PLoS One 6:e18595
|Williams, Sion L; Huang, Jia; Edwards, Yvonne J K et al. (2010) The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metab 12:675-82


text: The Clone Wars cartoon will get an ending, courtesy of Dark HorseRob Bricken1/08/14 4:20pmFiled to: star warsclone warsdisneydark horsecomicsanimation534EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Dark Horse may be losing the Star Wars comics license next year, but they're clearly trying to end it right — including the new announcement that the Clone Wars cartoon will get a real, official ending courtesy of a new four-part comic miniseries, beginning this summer. Advertisement I don't need to tell Clone Wars fans that the cartoon didn't "end" as much as "stop", as new rights holders Disney decided to close up shop to begin work on a new Star Wars cartoon to air on their own Disney XD channel. According to The Hollywood Reporter, a screenplay for a four-part cartoon miniseries, which was intended to be the actual finale, was written but obviously never made. Dark Horse is turning that into this comic series, which will be titled Darth Maul: Son of Dathomir. "All you need to know is that Darth Maul has returned, that he's really pissed off, and that his former master Darth Sidious is determined to put him back in the ground, permanently," writer Jeremy Barlow told Newsarama.This is awesome, and this news makes me even sadder that Dark Horse is losing the Star Wars license. I feel they should get at least another bonus year for this, don't you?Reply53 repliesLeave a reply


text:
Alternative Title: John David Tatum
Jack Tatum (John David Tatum), (born Nov. 18, 1948, Cherryville, N.C.—died July 27, 2010, Oakland, Calif.), American football player who earned the nickname "the Assassin" with his exceptionally hard tackles, one of which paralyzed New England Patriots wide receiver Darryl Stingley in a 1978 NFL preseason game. Tatum spent nine seasons (1971–79) with the NFL Oakland Raiders, where his brutal hits, 30 interceptions, and quality play at safety contributed to the team's tough reputation and 1977 Super Bowl championship. He garnered special notice in 1972 with the controversial "Immaculate Reception," when he deflected a pass by Pittsburgh Steelers quarterback Terry Bradshaw, which ... (100 of 256 words)


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|Frequency Response
|10Hz ~ 100kHz, 0dB ~ -3.0 dB (Optical 1, Optical 2, Coaxial, Analog, USB)
|Power Output
|300W total RMS, 55W x 3 (Front), 16W x 2 (Surround), 102W x 1 (Subwoofer)
|Inputs / Outputs
|Toslink optical digital x 2, coaxial digital, stereo analog, USB 1.1 port
|140 x 165 x 83mm (Satellite) and 406 x 235 x 41mm (Subwoofer)
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