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You cut the bark with a knife. If it's soft and green the tree is still alive. But at a certain point the growth has been retarded enough that you should replace the tree whether it's going to survive or not.
post #2296 of 6775
5/9/14 at 9:11am
They are talking about soil samples taken to labs to figure out a fungus or disease regiment....I don't want to take it that far, just quite yet. That why I thought I'd ask the community here about how to "baby" a tree that is possibly just in shock.


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The gloves finally came off at Laguna Seca in 2008, and The Aussie bit the dust while The Italian went on to win. It should have ended there, but Casey never stopped bitching...
"There's a lot of adrenaline before the race, but it's a good feeling. But after the race starts, you are in another dimension. You get this high level of concentration and do what you have to do. Everything becomes clear," says Valentino Rossi, in the December 2012 issue of Dainese's magazine, Legends. Now 33 years old, the indomitable Italian rider dominated premier class motorcycle grand prix racings in the 2000s, winning no less than seven MotoGP world championships from 2001 to 2009. And with 105 race wins to date, he is second only to that other great Italian motorcycle racer, Giacomo Agostini, who won 122 races in his racing career.
Only Nicky Hayden, in 2006, and then Casey Stoner, in 2007, were able to stall The Doctor's steamroller. And even then, Nicky's 2006 MotoGP world championship win was possibly just a fluke, a freak happenstance, since the Kentucky Kid hasn't been able to win a single race from 2007 onwards. But Stoner and Rossi have been going at it hammer and tongs for the last few years, each making no bones about the dislike they harbour for the other. In the end, Stoner decided to retire at the end of this year, having taken two MotoGP world championships (2007, with Ducati, and 2011, with Honda) in his career, while Rossi still seems to be in a different league altogether with his seven MotoGP world championships.
One race that MotoGP fans still remember is the 2008 race at Laguna Seca, where Stoner and Rossi had a ferocious battle, with the Italian finally winning the race and the Australian rider biting the dust. And as most followers of the sport already know, Casey could never stop whining about it. "Stoner started to hate me just because he lost. After that [the 2008 USGP at Laguna], he always seemed to talk about the past, this race, because he wasn't man enough to understand that at that time, he lost!" says Rossi.

subset: commoncrawl


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- Medium
- Burlap and India ink on cardboard on composition board
- Dimensions
- 13 7/8 x 10 x 2 1/8" (34.1 x 25.5 x 6 cm)
- Credit
- The Riklis Collection of McCrory Corporation
- Object number
- 986.1983
- Department
- Painting and Sculpture
This work is not on view.
Iurii Annenkov has 4 works online.
There are 2,314 paintings online.
Provenance Research Project
This work is included in the Provenance Research Project, which investigates the ownership history of works in MoMA's collection.
Meshulam Riklis, McCrory Corporation. By 1978
The Museum of Modern Art, New York. The Riklis Collection of McCrory Corporation, 1983
The Museum of Modern Art, New York. The Riklis Collection of McCrory Corporation, 1983
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Wego.com.sg recently found 3 hotels in Basalt, United States. Find a range of accommodation in Basalt at great prices. Book luxury Basalt hotels or find last minute accommodation. Save more on cheap hotels in Basalt with affordable room rates.
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Tube and Pipe Production | Articles | The Tube & Pipe Journal
April 15, 2008 | By Jeff Shelton
If you're a tube or pipe producer, you're probably under constant pressure to cut costs. And you probably know that you can reduce your raw material costs by reducing the coil width, within reason, and the change will have little noticeable impact on the final product's quality. However, this doesn't give you license to make wholesale significant width reductions. In fact, you'd probably be better off developing a comprehensive process optimization program and striving for higher efficiency instead of merely cutting costs.


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To be successful in this data-dependent world, you need to connect and share information between applications. The problem is, data integration is complex, messy, and keeps you from getting down to business. You don't want to think about data integration and neither do your customers.
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Actian removes the delivery model discussion from the data integration equation. We focus on enabling our customers to achieve their business goals. That being said, our integration platform is enterprise-grade and feature-rich and can be delivered via the cloud, on premises, hybrid model or our Engineered service – which is delivered by Actian subject-matter experts via our cloud platform.
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The extra firm cactus bristle is excellent for really removing stubborn dirt under the nails and on the hands. The bristles remain stiff even in water and improve with age. The short stiff bristles on one side clean under nails effectively while the longer bristles on the other soften cuticles and stimulate the nail bed for healthy nail growth while exfoliating the skin and boosting blood flow for smoother younger looking hands. Perfect for gardeners and the hands on! Wood: Beechwood (FSC® Certified)
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When Conner was 12, he stops dating, he isolates himself. Why? Because he thinks his life is ruined when he finds out he has to get married to a girl he doesn't know when he turns 18. When the day comes and his new family comes and picks him up, he meets his fiancé, Disarray. Right when he think he's going to hate her and not find himself liking the beautiful rich girl, he's wrong.
ReadForeverG Mar 24, 2016
When i was twelve i have a two year boyfriend ..... It lasted until 9th grade and i realized that im was to horny and he didnt satisfy me ...
rockstarhemmings May 20, 2016
CAUSE I DONT EVEN KNOW YOUR NAMEEE ALL I REMEMBER IS THAT SMILE ON YOUR FACEE..okay just because I'm practically an emo doesn't mean I can't love shawn mendes
trance-likegetaway Jan 12, 2016
okay I'm all for rebelling against parents, but you do NOT swear at them.
Insanity_wolf_dream Oct 28, 2015
This is really good but you need to edit and revise your story. I've noticed many words are spelled incorrectly and you should use more advanced vocabulary. Just constructive criticism ❤
tasha_nandani_S Mar 29, 2015
At least that's 12 I see prep literally prep kids saying guys I'm engaged to my boyfriend
chelseareneedenny Feb 24, 2015
my little brother is twelve haha and he really likes a girl!!


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NY Jets Message Board
New York Jets Videos
JetNation On Facebook
The NFL announced the compensatory picks for the upcoming NFL draft. The Jets have gained an extra 3rd round pick, 107th overall. #jetnation #nfldraft2017 #nyjets ... See MoreSee Less
Revis will make $13 million in salary from the Jets if they don't release him. $6 million of that is guaranteed. ... See MoreSee Less
Jets Release Folk & Giacomini ... See MoreSee Less
The NY Jets have announced that they have released kicker Nick Folk and RT Breno Giacomini. Chris Lopresti is reporting that these moves free up 7.5 million against the salary cap. Nick Folk, who i…


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Window Dressing
The Wolf in Sheep Clothing ...Business, File, Nelson.Work March 6, 2015
Marketing these days defeat the whole purpose to build; especially when cheating to win by manipulating the social media tools is a daily norm. Faking likes, dislikes, and comments is a very profitable niche industry. Spreading like an infectious virus among the on-line community whom is actively participating in disseminating information. Much of these skill-set are readily, and cheaply available for unethical brand to leap … — Read More
The difference between a politician and a statesman is that a politician thinks about the next election while the statesman think about the next generation. - James Freeman Clarke


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Geir Magnusson Jr <g...@pobox.com>
|Re: [performance] performance measurement of HDK
|Wed, 09 Aug 2006 00:37:16 GMT
Rana Dasgupta wrote: > Before tracking detailed EM/JIT profiling information( which we may need at > some point ), it may be useful to initially just track benchmark raw scores > weekly to see overall progress/regression and make it publicly available. > If there are licensing issues with SpecJVM and SpecJBB, we could use a > broad > public suite like JavaGrande. We could just run this externally weekly > on the same reference machine and post the numbers. Sure - but there's no harm in the profiling info either. > > We need to decide what we want to use benchmarks for. If it to be used > internally primarily for performance health, we could consider requiring > reporting before and after scores as part of JIRA code submissions along > with smoke test logs. For this, in addition to the jitted code oriented > ones > like Linpack, Scimark, we also need the memory benchmarks like decapo. We > could also start filing perf bugs. But given that DRLVM will change > significantly for some time, it seems too early to do this. Yep. And a real discouragement for people to contribute. > > To report/publish competitive scores we will need the rights to run > specJVM98, specjbb2005, specjAPPServer etc. In addition to licensing, this > also has some minimal infrastructure needs. Again, we can do do the prep > work, but it maybe too early to post competitive scores. Right - I'm not so worried about the spec scores at this point. Just working with apps that people can really identify with should be a good start. geir > > Thanks, > Rana > > > On 8/2/06, Mikhail Fursov <email@example.com> wrote: >> >> In my opinion this is a very good idea to have public performance profile >> with a hotspots identified. >> So, if this idea is accepted by community we can start a discussion which >> kind of profile might be useful. >> >> I know that execution manager and optimizing JIT in DRLVM have a command >> line keys to dump a lot of useful profiling information. I hope that >> other >> components have such switches too. So the only thing we need to do first >> (if >> the your proposal is accepted) is to write a tool to parses this data and >> shows as webpage. I can help to anyone with this task (importing profile >> from DRLVM JIT/EM) or just find a time and do it by myself if no >> volunteers >> will be found.. >> >> On 8/2/06, Stefano Mazzocchi <firstname.lastname@example.com> wrote: >> > >> > one thing that happened in mozilla-land that catalized the community in >> > fixing leaks and performance issues was adding profiling information to >> > the tests and start plotting them overtime. >> > >> > Not only that gives an idea of the evolution of the program performance >> > overtime, but it also keeps people honest because profiling is not >> > something that should be done once and being forgotten but something >> > that should be considered part of the feature of the program. >> > >> > -- >> > Stefano. >> > >> > >> >> -- >> Mikhail Fursov >> >> > --------------------------------------------------------------------- Terms of use : http://incubator.apache.org/harmony/mailing.html To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: email@example.com
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Kyowa Hakko Kirin Submits Application for Approval of REGPARA ® Tablets 12.5mg in Japan
Tokyo, Japan, March 25, 2014---Kyowa Hakko Kirin Co., Ltd. (Tokyo: 4151, President and CEO: Nobuo Hanai, "Kyowa Hakko Kirin") announced today that it has filed an application for marketing approval to Japan's Ministry of Health, Labour and Welfare (MHLW) for REGPARA® Tablets 12.5mg(generic name: cinacalcet hydrochloride).
REGPARA® (tablets 25mg and 75mg) acts on calcium receptors on the parathyroid gland to suppress the secretion of parathyroid hormone (PTH). REGPARA® tablets 25mg and 75mg were launched in January 2008 for secondary hyperparathyroidism (HPT) in patients who are undergoing regular dialysis. In February 2014, the drug had received the approval for hypercalcemia in patients with parathyroid carcinoma, and hypercalcemia in patients with primary HPT who are unable to undergo parathyroidectomy or who experience recurrent primary HPT.
REGPARA® has been marketed in Japan for six years and used to treat many patients, but individual patients vary in their response to or tolerance of the drug. Therefore, Kyowa Hakko Kirin applied for manufacturing and marketing approval of REGPARA® Tablets 12.5mg to provide a lower dosage form to allow doctors to finely adjust the drug dose.
Kyowa Hakko Kirin is focusing on kidney area, along with three other focused areas as our category-based strategy*. With variety kinds of products, Kyowa Hakko Kirin will contribute for kidney diseases.
*Category-based strategy: Each category (Nephrology; Oncology; Immunology and allergy; and Central Nervous System) will have its own portfolio management from R&D through to sales. We will achieve sustained growth while striving to improve productivity.
News Source : Kyowa Hakko Kirin Submits Application for Approval of REGPARA ® Tablets 12.5mg in Japan
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- Tablets 12.5mg in Japan
- Approval for Additional Indication of REGPARA ® Tablets 25mg and 75mg
- Approval of Long-Acting Erythropoiesis-Stimulating Agent NESP ® Injection 5μg Plastic Syringe in Japan
- Launch of Long-Acting Erythropoiesis-Stimulating Agent NESP ® Injection 5 μg Plastic Syringe in Japan
- Approval of Additional Indication of Long-Acting Erythropoiesis-Stimulating Agent NESP ® for Pediatric Patients with renal anemia in Japan
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Corporate Governance Consequences of Accounting Scandals: Evidence from Top Management, CFO and Auditor Turnover
Anup Agrawal
University of Alabama - Culverhouse College of Commerce & Business Administration
Tommy Cooper
University of Alabama - Department of Economics, Finance and Legal Studies
September 15, 2015
Quarterly Journal of Finance, 2016, Forthcoming
This paper examines the consequences of accounting scandals to top management, top financial officers, and outside auditors. We examine a sample of 518 U.S. public companies that announced earnings-decreasing restatements during the 1997-2002 period and an industry-size matched sample of control firms. Using logistic regressions that control for other determinants of management turnover, we find strong evidence of greater turnover of CEOs, top management and CFOs of restating firms compared to the control sample. Over the three years surrounding the year of restatement announcement, CEOs and CFOs, respectively, face a 14% and 10% greater probability of being replaced in restating firms than in control firms, after controlling for other factors. These represent increases of about 42% and 23%, respectively, compared to the usual turnover probabilities. The magnitudes of these effects are even larger for restatements that are more serious, have worse effects on stock prices, result in negative restated earnings, are initiated by outside parties, are accompanied by AAERs, or trigger securities class action lawsuits. We find little systematic evidence that auditor turnover is higher in restating firms. Our paper provides evidence of effective functioning of internal governance mechanisms following accounting scandals.
Number of Pages in PDF File: 48
Keywords: Management turnover, CFO turnover, Auditor turnover, Accounting scandals, Earnings manipulation, Earnings restatements, Financial restatements
JEL Classification: G34, M43, K22
Date posted: March 5, 2008 ; Last revised: September 16, 2015
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Am Wasser, Dachrestaurant/landschaftlich, Romantik/Erste Verabredung, Ruhig/friedlich, Feinspeisen
Opening Hour
10.00 - 22.00
Opening Days
The Colonial House Art Gallery and Riverside Thai Restaurant with soft live music. Open daily from 11 a.m.-12 p.m.
There is no review available for this place at the moment. If you've been there and would like to write a review, please visit TripAdvisor.com


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Lot 265: (3pc) CARL KOCH FOR VERMONT TUBBS
November 6 Estate Auction
by Butterscotch Auction Gallery LLC
06 November 2016
Bedford Village, NY, USALive Auction
Looking for the realised and estimated price?
Description: two Sno-Shu chairs and an ottoman, New Hampshire, ca. 1952; Ash and gut, h. 34 w. 27-1/2 d. 32-1/2 in.
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Alliance Party east Belfast alert was a hoax, PSNI say
- 19 July 2014
- From the section Northern Ireland
A suspicious package left outside an Alliance Party office in east Belfast has been declared a hoax.
Army explosives experts were called out to deal with a suspect package at the offices on the Newtownards Road on Friday night.
Roads were sealed off and traffic diverted as a controlled explosion was carried out.
The premises, used by East Belfast MP Naomi Long, have been targeted a number of times.
Most recently, petrol bomb attacks were carried out on the offices on consecutive nights in April and May.
The attacks began following a Belfast City Council vote in December 2012 restricting the flying of the union flag at the City Hall.
Condemning the latest hoax, Alliance MLA Chris Lyttle said: "It is a serious incident for the local area, it causes serious disruption, it puts people's lives at risk, it can prevent emergency services reaching the area.
"Ultimately we need people with information to share that with the police in order for them to do their job and bring these people to justice."


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This Lent, take a 40-day devotional journey with Dietrich Bonhoeffer. Click here to sign up.
9:11 this mad fellow. Because of their unusual lifestyle, eccentric habits, and ecstatic prophetic messages, the prophets struck some people as deranged (cf. Jer. 29:26; Hos. 9:7).
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Jun 11, 2013, 09.52 AM | Source: Forbes India
Edelweiss Group's Rashesh Shah recalls the crises he faced in setting up his business, and how he turned them into opportunities.
Edelweiss Group's Rashesh Shah recalls the crises he faced in setting up his business, and how he turned them into opportunities
Have you seen batman? in the movie, the butler Alfred asks young Bruce Wayne something profound, "Why do we fall, sir? So we can learn to pick ourselves up." Every setback is an opportunity. When we started Edelweiss in 1996, we wanted to be a Category-1 merchant bank. There were more than 440 such banks, we wanted to be the 441st. At that time, the rule was you had to have a net worth of Rs 1 crore to qualify as a merchant banker.
Initially, my co-founder Venkat Ramaswamy and I were only able to pool together about Rs 50 lakh from our own savings. We spent almost six months convincing our families: I took a Rs 25 lakh loan from Citibank and mortgaged my house, and Venkat borrowed some money from his father. We somehow managed to scrape together the additional Rs 50 lakh we needed to apply for the licence. We thought we would be a merchant bank doing IPOs, right issues and things like that. And just as we were making our application to Sebi, the rules changed to a minimum capital requirement of Rs 5 crore!
Our entire business plan went out of the window. I was in shock for weeks. We managed to go from Rs 50 lakh to Rs 1 crore by fighting for each lakh, but Rs 5 crore was impossible. After cajoling and convincing our families for additional capital, I learned that things can change in a jiffy.
The change, however, was a blessing in disguise. We started working on private equity syndication and mergers and acquisitions (M&A). In those days, there was no intermediary, there was no merchant bank focusing on private equity. It made us change our business plan completely.
Only in 2000 did we cross the Rs 5 crore capital mark, and finally become a Category-1 merchant bank. But in those five years, the work we did was pure advisory instead of focusing on equity capital markets. Advisory became our calling card and we became market leaders. We were advising on private equity when there was no private equity in India.
It was the crisis that made us create this new business model. Every setback is an opportunity to recalibrate, and fortunately in India there's always an opportunity. I believe if one window closes, three will open up. You need to have the conviction that there are other windows out there and look for them.
We didn't flick the switch in one day: As the weeks passed and we went ahead with our business, we realised there was a lot of advisory work that wasn't Category-1. Within a year, we were advising at least five companies on private equity and a couple more on M&A. There was a business model there. The experience hardened us and helped us grow. We now see change as an opportunity. Looking back, now it seems small, but back then it was an existential issue.
It was yet another crisis that made us evolve again. During the 2000 dotcom bubble, we saw ourselves as a technology specialist with a focus on BPOs. But, as the bubble burst in 2001, we had to rethink our strategy once more. But this time it was easier. We expanded from a pure advisory investment bank to a broad-based capital markets firm.
It has become a theme for us: Every time there is a setback, we use it as an opportunity to expand the business model by taking big operational risks as opposed to financial risks. Operating risk means hiring the right people and investing in them.
When the tech bubble burst, we had 10 people. A year later, after the business had totally collapsed and 9/11 had happened, we had 40. We acquired a broking arm, we started the futures and options equities and derivatives, and became market leaders in that; we set up an analytics team for equities and raised some risk capital.
After a setback, the normal human instinct is to go back into a shell, hunker down and protect what you have. But we use it as an opportunity to quietly and sensibly discover which new windows have opened up.
By 2003, we were 60 people. From 60 we went to 140, then 300, then 800 to our peak of 1,800 in 2008.
The fact that we had opened those windows helped us scale up when the growth came back. Instead of hunkering down, we said, "Let's take calculated risks in adjacent markets."
There are a number of ways to keep your head and stay grounded in times of extreme growth:
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Shamed fashion designer John Galliano cannot remember an anti-Semitic rant he is facing criminal charges over because he was out of control on drugs and pills at the time, a court heard today.
The British former Dior star - he was sacked after the incident - said he was addicted to alcohol and prescription drugs at the time.
"I have a triple addiction. I'm a recovering alcoholic and a recovering addict," he told the court.
He said he started drinking in 2007 and became addicted to alcohol, barbiturates and sleeping pills.
He said he had since undergone rehabilitation treatment in Arizona for two months and in Switzerland.
"After every creative high, I would crash and the alcohol helped me," he said, adding that his creativity "helped make Dior a billion-dollar business."
Asked why he didn't tell police investigators about his addictions, Galliano responded: "I was in denial. I was still taking those pills and alcohol, and I was in complete denial."
Galliano's appearance at the one-day trial in Paris put him in the public eye for the first time in months.
In a conservative look for him, he was dressed in black with a polka dot neckerchief, wearing a pencil moustache and long hair.
Galliano is charged with "public insults based on origin, religious affiliation, race or ethnicity" and could face up to six months in prison and 22,500 euros (£20,000) in fines. The verdict is expected at a later date.
The designer was escorted to a front-row seat in the wood-panelled, gilded courtroom at the Justice Palace, sitting next to an interpreter as he faced the three judges presiding over his fate.
Asked about the specifics of the evening of February 24, 2011, when he allegedly attacked a couple in a Paris cafe with the insults, Galliano repeatedly said he remembered nothing.
Days after the February bar incident, a video was shown on the website of The Sun showing an inebriated Galliano insulting a fellow cafe client, slurring: "I love Hitler."
In court, Galliano described increasing work loads at Dior and his signature label, John Galliano, in part as a response to the financial crisis. "They kept me very busy," he said, adding that he had not had time to mourn after the 2007 death of his right hand man and the 2005 death of his father.
His lawyer, Aurelien Hamelle, said outside court that the designer's comments were "misplaced and hurtful" but attributed them to Galliano's addition to alcohol and prescription drugs.
Galliano issued a statement at the time saying: "Anti-Semitism and racism have no part in our society. I unreservedly apologise for my behaviour in causing any offense." He also said he was "seeking help" for personal failures.
The lawyer said he would be calling witnesses at the cafe during both incidents who say they did not hear any insults by Galliano.
French law prohibits public insults toward others because of their origins, race or religion.
If the court determines that the insults against the victims were heard by other people, it would be a crime and a conviction could lead to a prison term. If such insults were not witnessed, they would only amount to a petty offence and be punishable by a fine.
The February cafe incident and the video reverberated throughout the fashion world because they emerged on the eve of Paris Fashion Week. Dior fired Galliano after 14 years with the company and denounced his comments.
The trial is being held on the opening day of another round of Paris fashion shows, the menswear spring-summer 2012 collection.
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- Alcohol
- British Fashion
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Friendly Takeover Offers for Public Corporations: Interim Uncertainty, Reserve Prices, and Bustup Fees
Bernard S. Black
Northwestern University - Pritzker School of Law; Northwestern University - Kellogg School of Management; European Corporate Governance Institute (ECGI)
Robert A. Dam
University of Colorado at Boulder - Department of Finance
March 15, 2012
Legal restrictions create a material delay between the announcement of a friendly acquisition of a public firm and the deal's final approval by target shareholders: a month for a takeover with a first step cash tender offer, longer for a merger. During this time target values may change, perhaps dramatically. While a target can accept new bids if its value rises, bidders usually cannot back out if the target's value falls. We also observe that most takeovers occur at a significant premium to the target's prior market price. Prior models of takeover bidding ignore the law-induced delay and resulting asymmetry between bidder and target, and generally assume that targets (if for sale) will accept zero-premium offers. We develop a model that incorporates delay-induced asymmetry and reserve prices. Principal new predictions include: targets often optimally set reserve prices higher than the current market price; first bidders may value the target for more than the target's reserve price, yet be unwilling to bid because they expect a loss after accounting for the implied put option they provide the seller; the likelihood of a bidder making a bid is generally decreasing in the reserve price, the interim uncertainty, and the number of potential competing bidders; optimal reserve prices are decreasing in the interim uncertainty and number of potential new bidders, and can be below the target's current price in extreme cases; (if the target offers a bustup fee to the first bidder, this increases the (conditional on the bustup fee) optimal reserve price, but reduces the target's expected profit. Our predictions on the effect of bustup fees provide theoretical support for legal limits on bustup fees and other deal protections.
Number of Pages in PDF File: 34
Keywords: mergers and acquisitions, reserve price, bustup fee, termination fee
JEL Classification: G34, G38
Date posted: March 24, 2012
Suggested Citation
Contact Information


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P R O J E C T I This project is a part of a program project directed at turning a platform for the expression of highly active glycan processing enzymes into new high-specificity tools for the synthesis of complex glycans, the detection of their existence on glycoproteins and glycolipids in cellular environments, and the monitoring of redistribution in the course of disease. This is no small task as there are an estimated 7000 distinct glycans in mammalian systems and ~200 glycosyltransferases (GTs) contributing to their synthesis in humans. We will take an important step toward accomplishing this task by building a molecular level understanding ofthe origin of GT specificity. The initial focus is a subset of GTs important in modifying the termini ofthe glycans on glycoproteins and glycolipids, members ofthe sialyltransferase and fucosyltransferase families, and building a protocol for the study of other families. Pursuit of three general aims will contribute to this understanding. 1) Substrate specificity of GTs will be characterized using glycan arrays to identify sugar residues and linkages where primary recognition occurs. Novel enzyme based technology will be developed to allow sensitive detection of recognized glycans and the results will be fed to internal and external collaborators to allow development of new synthetic procedures and tagging strategies that will further expand arrays. 2) Atomic level structures of GTs and their bound sugar donors and acceptors will be produced. A combination of X-ray crystallography and NMR methodology will be applied, taking particular advantage ofthe expression platform's ability to produce homogeneously glycosylated GTs for crystallography and sparse isotope labeled GTs for NMR investigation. The resulting structures will provide information needed forthe rational design of functionalized acceptor and donor analogs, as well as future GT inhibitors and genetically modified enzymes. 3) The efficiency and specificity of glycosyltransferase reactions will be examined in cellular environments using a glycoprotein substrate in order to assess the influence of a protein context and cellular location on GT specificity. The information will be essential in extrapolating molecular level specificities to action of enzyme-based reagents in vivo.
The diverse set of glycans (sugars) that are found on human proteins and lipids influence processes from cell development to cell-cell interaction and the lifetime of signaling molecules in serum. Knowledge ofthe enzymatic synthesis of these structures is important to detection, diagnosis, and understanding disease. The proposed studies will examine the enzymatic and structural basis for glycan biosynthesis.
|Praissman, Jeremy L; Wells, Lance (2014) Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates. Biochemistry 53:3066-78
|Bullard, Whitney; Lopes da Rosa-Spiegler, Jessica; Liu, Shuo et al. (2014) Identification of the glucosyltransferase that converts hydroxymethyluracil to base J in the trypanosomatid genome. J Biol Chem 289:20273-82
|Teo, Chin Fen; Wells, Lance (2014) Monitoring protein O-linked ?-N-acetylglucosamine status via metabolic labeling and copper-free click chemistry. Anal Biochem 464:70-2
|Praissman, Jeremy L; Live, David H; Wang, Shuo et al. (2014) B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of ?-dystroglycan. Elife 3:
|Prudden, Anthony R; Chinoy, Zoeisha S; Wolfert, Margreet A et al. (2014) A multifunctional anomeric linker for the chemoenzymatic synthesis of complex oligosaccharides. Chem Commun (Camb) 50:7132-5


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Q1: Is your lifestyle killing you? Not sure? Let's look at your physical activity…
Q2: Last week did you do over 150min of physical activity that got you warm and slightly out of breath? Did you try to move more and sit less?!
In the UK we know that 33% of men and 45% women do not do enough physical activity for good health.
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Source: Public Health England
Read on to get one step closer to adding 10 minutes of activity every day.


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Toledo police have arrested a second suspect in a September shooting death of a Toledo man. Davonte Nicholson, 21, of 1017 Avondale Ave., who was arrested Tuesday, was charged with premeditated aggravated murder in the Sept. 9 death of George Smith,
NORTON, Ohio — When the two Norton, Ohio patrolmen saw the car in the middle of the street Sunday night, fully engulfed in flames, they started sprinting. Somebody is in the car, patrolman Brody Fratantonio thought to himself, he told local
Has been away from duty since June for firing fatal shot.
Amendment aims for upcoming ballot.
Retired police officer leaves behind 3 daughters.
Charged with delinquency after 5-minute car chase
He has not worked since June 16 shooting near Montpelier.
He took vehicle to go shopping
Authorities have identified a retired Toledo police officer as the man who was found dead in a burning North Toledo house Monday evening. Gerald Kwiatkowski, 84, retired from the police department at age 55 on Dec. 31, 1987 with the rank of
Fatal blaze on Brophy Drive, near border of Washington Township.


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Dedicated to improving the mundane task of carrying everyday essentials, leather accessory purveyor Bellroy created a short film showcasing various scenes that form the inspiration for their Australian-based company. Characterized by crisp visuals, rich lighting and a smooth depth of field, the footage highlights some of the processes, elements, and craftsmanship that go into the creation of their small leather goods and wallets. The brand's latest styles recently released for Fall/Winter 2011 and are now available through the Bellroy online store.


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General Dynamics (NYSE:GD) is a worldwide aerospace and defense company headquartered in Falls Church, VA. It has around 96,000 employees. GD operates through four business groups: Aerospace, Combat Systems, Marine Systems, and Information Systems and Technology. The U.S. government is its largest customer.
There are several competitors to GD such as Lockheed Martin (NYSE:LMT), Northrop Grumman (NYSE:NOC), Textron (NYSE:TXT), United Technologies (NYSE:UTX), Honeywell (NYSE:HON), Boeing (NYSE:BA), and others. For simplicity, we will choose to compare GD to Lockheed and Northrop.
GD trades at a trailing twelve month P/E of 17.6 versus the Aerospace and Defense average of 19.52. GD is trading at slightly higher P/E than LMT and much higher than NOC.
GD PE Ratio (TTM) data by YCharts
The Price/Sales (trailing twelve months) of 1.34 is reasonable and below the industry average of 1.66, but above competitors Lockheed Martin and Northrop Grumman.
GD PS Ratio (TTM) data by YCharts
The price to book for GD is 2.98 versus 10.60 for the industry average and well below LMT.
GD Price to Book Value data by YCharts
Based on several valuation measures, GD is valued below the market and below the industry, but higher than its historical norms.
GD is estimated to grow its earnings at 6.94% over the next year and 7.83% per year over the next 3-5 years. (source Fidelity.com)
This is below the industry average of 10.96% and 10.39%, respectively, and comparable to NOC. LMT has a projected 3-5 year growth rate of 8.88%.
Sales growth is projected to be 1.28% per year over the next 5 years for GD. LMT is 1.20% and NOC is -6.16%. All three have seen sales growth slowing over the past three years.
GD profit margin (trailing twelve months) is 8.06%, versus 6.95% for LMT and 8.37% for NOC.
The EBITD Margin (trailing twelve months) is 13.88% versus 13.08% for LMT and 15.17% for NOC.
The operating margin (trailing twelve months) is 12.13% for GD, versus 10.87% for LMT and 13.15% for NOC. All three companies have improved their operating margins recently.
This is how Return on Assets and Return on Invested Capital has looked for the three:
GD Return on Assets (TTM) data by YCharts
GD has trailed LMT on Return on Assets and ROIC, and is comparable to NOC.
Cash & Debt:
Long-Term Debt/Equity: GD: 28.8%, LMT: 210%, NOC: 59.1%
Debt to Assets: GD: 11.2%, LMT: 16.3%, NOC: 22.2%
Debt to Capital: GD: 22.1%, LMT: 56.2%, NOC: 35.9%
Current ratio for all three is above 1.2.
GD has a dividend yield of 2.07% with a 34.8% payout ratio.
LMT has a dividend yield of 3.22% with a 55.5% payout ratio.
NOC has a dividend yield of 2.27% with a 31.3% payout ratio.
All three have grown their dividend by over 10% per year over the past 5 years.
GD has increased its dividend 16 years in a row, while LMT has increased it 11 years in a row, and NOC is 6. (NOC was formed in 1994).
After viewing the careers section of the websites, we found the following:
All three companies are aggressively hiring right now from 2000-3000 jobs, with hundreds of them posted recently. This is a great sign and something we always look at.
Fundamentally, NOC is trading at the best valuation, but GD is not overvalued. All three are estimated to have solid earnings growth over the next 3-5 years in the 7-9% range. But sales growth has been slowing and looks to continue to be slow. Margins are a little better with NOC and GD than LMT, but all are solid and have actually increased recently.
Based on the above, we would give the edge to NOC and GD, but LMT is solid also.
Let's look at the stock charts:
GD and LMT have tracked closely together, while NOC has separated itself over the past year and may revert back near the others.
General Dynamics specifically is in a clearly defined uptrend:
As for an entry point, the $115-$118 price looks relatively attractive for long-term holders.
In conclusion, the aerospace and defense industry as a whole looks to be undervalued relative to the market, but overvalued relative to its own historical figures. This is enough reason to not jump in right away.
However, with a new administration entering office soon, tensions constantly stretched overseas, and new technologies (drones) becoming more important, this dynamic industry will always be needed. In fact, the big defense companies have some room to make up in the drone area. Northrop is the biggest player among the companies mentioned, but LMT, GD and BA are also participating.
General Dynamics pays a solid dividend, has been growing it steadily, has plenty of room left to increase, and has growing cash and low debt. They are aggressively hiring for positions all over the world.
There may be better entry points for the stock price, but it has good relative strength, and is in a clear uptrend. Using a DCF analysis and 7.8% earnings growth rate over the next 5 years, we have a fair value of GD at $126.44.
Additionally, using those same numbers, and assuming a reversion to the mean for P/E of 14 from 16.8, we are projecting a 5-year average annual total return of 6.22% (~4% capital gain, 2.22% dividend).
For patient investors, General Dynamics looks like a reasonable buy in the $118 area.
Disclosure: The author has no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. The author wrote this article themselves, and it expresses their own opinions. The author is not receiving compensation for it (other than from Seeking Alpha). The author has no business relationship with any company whose stock is mentioned in this article.


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An upcoming redevelopment slated for three buildings on the corner of Magazine and Nashville streets means that a handful of local shops are moving to make way for a New York City-based business, small business owners and the location's development company said this week.
Butler Callahan Holdings development company bought the property on the 5700 block of Magazine, in an area that currently houses the three specialty shops Rare Cuts, Vom Fass and Parcels and Post. Ben Butler, a managing partner of the company, said Thursday that while he can't yet announce the name of any new businesses slated to take over the spot, he can say that the company is "in lease negotiations with a very exciting tenant out of New York City." Continue reading »


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text: levees With Waters Rising, Army Corps Likely To Open Bonnet Carré Spillway To Protect New Orleans By Tegan Wendland • Jan 5, 2016 Tegan Wendland / WWNO As the Mississippi and Red Rivers rise, officials are grappling with how to manage all of the water. The Army Corps of Engineers may open the Mississippi River's Bonnet Carré Spillway this weekend. New Orleans District Commander, Col. Rick Hansen, says it is time to open the spillway. Just west of the city, it diverts the Mississippi River to protect New Orleans. Flood Warning Issued For New Orleans Area By Tegan Wendland • Jan 5, 2016 National Weather Service The National Weather Service has issued a flood warning for the Mississippi River in New Orleans and surrounding areas, effective January 12. This comes as floodwater from devastating winter rain in the Midwest makes its way south. The river is expected to reach flood stage, 17 feet, in the next week. Rain is also in the forecast starting Wednesday night, adding to the risk of flooding. NWS warns not to drive cars through flooded areas. New Technology Tested Along The Gulf Intracoastal Waterway, A Battle Line For Saltwater Intrusion By Nick Janzen • Dec 22, 2015 Nick Janzen The Gulf Intracoastal Waterway is a shipping canal that runs over 1,000 miles from Texas to Florida. But in Lafourche Parish, it's become more than an industrial throughway. It's a battle line against coastal erosion, and experts are determined to keep saltwater out of it. How Secure Is The New Orleans Levee System? By Jesse Hardman • Sep 11, 2015 Jesse Hardman Over the last decade more than $14 billion was spent to upgrade New Orleans's storm protection system. But ask around, and you'll get a variety of responses as to how safe the city actually is now when it comes to storms and flooding. Mark Schleifstein is the Environment reporter for Nola.com | The Times-Picayune. He's been covering all facets of New Orleans's attempts to shore up it's natural and man-made defense systems. St. Charles Parish Coastal Plan Up For Public Review By Tegan Wendland • Sep 10, 2015 St. Charles Parish Government St Charles Parish officials hope to gain more control over their local wetlands by adopting their own coastal plan. A Decade After Disaster, Army Corps Touts Infrastructure Improvements By Tegan Wendland • Aug 25, 2015 Tegan Wendland / WWNO Ten years after Katrina, the Army Corps of Engineers says it is ready for the next big one. The Corps has built new levees, floodwalls and gated structures over the past decade to protect the city and its people. Corps To 'Armor' Levees To Protect Against Erosion By Laine Kaplan-Levenson • Jun 2, 2015 Paul Floro / Army Corps of Engineers The Army Corps of Engineers held a public meeting to discuss a new project that will add fabric matting and natural grasses to the top of the levees along the lakefront. The design aims to protect from surges caused by a 100-year storm. The Corps refers to this project as "armoring" the levees. The existing system is defined to withstand a hurricane with a 1 percent chance of occurring any given year: a "100-year storm." This armoring strategy is being put in place in case there's an even stronger storm that breaches those levees. Pentagon Announces Levee Armoring Contracts By Associated Press • Dec 16, 2014 The Pentagon says three Louisiana companies have contracts worth up to $200 million in total to armor levees in the New Orleans area. The Pentagon says Bis Services of Kenner, Circle of Belle Chasse, and Shavers-Whittle Construction of Mandeville, were among 10 companies that bid over the Internet. Their contracts are with the Army Corps of Engineers in New Orleans. They were on a list of contracts released last night by the Pentagon. The work is to be done by December 2020. The amount paid for each job will be decided individually. With SLFPA-E Nomination, Fate of Lawsuit and Levees Hangs in the Balance By Amy Jeffries • Oct 3, 2014 Listen Listening... / The nominating committee for the South East Louisiana Flood Protection Authority-East has made its selection to fill a slot on the levee board. They voted 7-3 a week ago to renominate Paul Kemp — a geologist in the Coastal Ecology Institute at LSU — who's current term is expiring. The ball is back in Gov. Jindal's court — he can accept or reject Kemp's nomination or ask the state Senate to consider it — and the fate of the levee board's lawsuit against oil and gas companies over damage to coastal wetlands hangs in the balance. Bob Marshall, reporter with The Lens in New Orleans, has been following all this. Debris Found In 17th Street Canal Levee By Eileen Fleming • Jul 11, 2014 U.S. Army Corps of Engineers The US Army Corps of Engineers says there is no major threat from debris found inside the 17th Street Canal levee. Corps critics aren't so sure. Chunks of concrete, bricks and glass were discovered during work to install sheet piling. The Southeast Louisiana Flood Protection District—East has been assured by the Corps that the material is being removed. Sandy Rosenthal founded Levees.org after the catastrophic levee breaches following Hurricane Katrina nine years ago. Pages1 2 3 next › last »


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Celebrity Gossip | Entertainment News | Celebrity News
Monday, July 1
Photo: Taribo West Arrives in Ghana to Spread Word of God
The Nigerian international footballer-turned pastor was spotted in Accra Ghana last week, he had arrived in Ghana to broadcast the word of God.
God bless him.
Posted by Laila Ijeoma at 7/01/2013 06:42:00 pm 8 comments:
Labels: celebrity pictures, taribo west
Hot Or Not? Genevieve Nnaji's Outfit For Ebony Live Launch
Posted by Laila Ijeoma at 7/01/2013 04:26:00 pm 22 comments:
Labels: celebrity pictures, genevieve nnaji
Nigeria's Hottest 'Female' Man, Joshua Agai Shares New Photos
If this is your first time of meeting Josh, then you need to click here.
Josh is something else! The eyelashes, the blue eyes...... Josh's style is...
Just in case, Josh wants to know who says he ain't hot. *winks
Continue for more pics
Posted by Laila Ijeoma at 7/01/2013 04:05:00 pm 22 comments:
Labels: celebrity pictures, joshua agai
Omotola Jalade Ekeinde Dazzles In New Photoshoot
Posted by Laila Ijeoma at 7/01/2013 03:23:00 pm 21 comments:
Labels: celebrity pictures, omotola jalade ekeinde
Why I Celebrated And Married My Wife In A Truck - Victor Osuagwu
Here is what actor Victor Osuagwu told Leadership magazine about his wife and marriage.
- Why did it take you almost 14 years before taking your wife to the altar?
Some people even said it was because I didn't have money to organise the wedding. But to me, it was a deliberate act. It was a promise made to God that when he blesses me I'm going to celebrate my marriage in a very big way. I don't owe my in-laws, everything about marriage was done in 2002 but
Posted by Laila Ijeoma at 7/01/2013 03:02:00 pm 26 comments:
Labels: celebrity stories, victor osuagwu
Mercy Aigbe @ Ebony Live TV Launch
Posted by Laila Ijeoma at 7/01/2013 02:57:00 pm 9 comments:
Labels: mercy aigbe
SHOCKING: Reverend Father Gets Beheaded By Militants Infront Of Cheering Crowd (Graphic Video & Pictures)
According to local sources, the monastery where Fr. Murad was staying was attacked by militants linked to the jihadi group Jabhat al-Nusra.
In the video, filmed on a camera phone and posted on LiveLeak, three men - including Father Francois - are seen sitting on the dusty ground as a crowd around them cheers.
The priest, wearing a brown robe, is filmed sitting cross-legged with his hands apparently bound.
He is pulled forward and laid face down on the grass as the crowd chant 'Allahu akbar' and take photos.
You'll notice there are even kids present while the dastard act was carried out when you watch the video. Apparently, these children are been groomed to become terrorists in the nearest future.
He is then decapitated, using what looks like a rudimentary kitchen knife.
See pictures below. VIEWER'S DISCRETION IS ADVISED!
Posted by Laila Ijeoma at 7/01/2013 01:46:00 pm 14 comments:
Labels: society stories
More Photos: Celebs @ Mo Abudu Ebony Tv Launch
The Ebony Life TV launch held last night in Eko Hotel & Suites, Lagos and had big acts Tiwa Savage and Banky W do a beautiful rendition of Onyeka Owenu and King Sunny Ade's 'If you love me, you will wait for me'.
At some point during their performance, they were joined by Onyeka and King Sunny Ade.
The show was hosted by Dare Art Alade and Dolapo Oni, and also had ex-governor Cross river State Donald Duke, present Governor Liyel Imoke in attendance.
MI, Wizkid also perfomed.
More pics below
Posted by Laila Ijeoma at 7/01/2013 12:22:00 pm 10 comments:
Labels: celebrity pictures, toolz, Uche Jombo -R
Check Out Rita Dominic & Chidynma's Outfits To Mo Abudu's Ebony Live Tv Launch Last Night
Posted by Laila Ijeoma at 7/01/2013 11:25:00 am 13 comments:
Labels: celebrity pictures, chidynma, mo abudu, rita dominic


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On April 29, 2014, the Versailles Appeal Court issued an interesting decision as regards assessment of likelihood of confusion between two French trademarks composed of Chinese characters and designating wine, the prior trademark being owned by the famous Domaines Barons de Rothschild (Lafite).
Given the nature of the signs, it was important to first determine the "relevant public" before assessing the similarities. Indeed, depending on the definition of the the targeted consumer the assessment takes into consideration all the visual, conceptual and phonetical components or only the sole visual components of both signs.
With the first two Chinese characters of the trademarks presumed to be identical, the applicant was therefore strongly claiming that likelihood of confusion should be assessed from the perspective of a Chinese consumer living in France (the Chinese community in France is one of the most important ones in Europe composed of about 600.000 people) and understanding Chinese language. It was claimed that this was the only consumer targeted to buy wines sold under a trademark composed of Chinese characters, rather than the average French consumer who is unlikely to perceive the Chinese meaning of the signs.
To support its claim, the applicant has given affidavits of Chinese translators asserting that both signs were phonetically and conceptually different, and referred to the description included in the trademark application forms indicating that the prior trademark was the transliteration of LAFITE DISTRIBUTION whereas the post application was the transliteration of LAFINESS. However, these circumstances were challenged by the owner of the prior trademark as irrelevant for the following reasons:
To convince the Court, the applicant has also produced numerous decisions which took into consideration specific targeted consumers to waive the likelihood of confusion between signs composed of foreign characters. For instance, the Paris First Instance Court, in a decision dated September 13 2012, considered that there was no imitation between the signs KOL-TOV and OF TOV within the mind of the consumers of kosher products, likely to perceive different meanings of each sign in Hebrew. However, this was strongly criticised by the prior trademark's owner as irrelevant since the solution was justified in this specific case by the strict definition of the relevant public due to the specific nature of the goods: kosher food products. Moreover, apart from the conceptual difference, both signs were also phonetically and visually different.
The Court, following the arguments raised by the owner of the prior trademark and the French Trademark Office, considered that the assessment shall not be restricted to one part of the targeted consumers, namely Chinese consumer or of Chinese origin, and given the nature of the products (staple goods), they were intended for an average consumer who was well informed and reasonably observant, and not familiar with the Chinese language. Since the Court has retained a broad definition of the relevant public - the French consumer unlikely to perceive the meaning of the signs - only a visual comparison between both signs was relevant. This visual comparison led the Court to uphold imitation.
This case is important for the protection of the prior trademark composed of Chinese characters, both in France and in China. Even with a different assessment (visual comparison/global comparison based on visual, aural and phonetical similarities), imitation has been successfully upheld in both countries, with other trademarks composed of the same two Chinese characters.
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DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
© Reed Smith
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1. In a medium bowl add in the strawberries and raspberries. Microwave for 5 minutes until hot and soft.
2. Take out the bowl from the microwave and add in the sugar free instant strawberry gelatin. Mix well and set aside.
3. In a medium bowl add in the egg, milk, vanilla and cinnamon. Whisk for few minutes.
4. Dip the bread into the egg mixture, until evenly coated on both sides.
5. Grease a large skillet with non – stick cooking spray. Place the bread slices and cook on medium heat until golden brown on both sides.
6. Serve Whole Wheat French Toast with Quick Berry Sauce.
Serving size Per servingComplete recipe
Calories 185 Calories from Fat 39
% Daily Value*
Total Fat 4 g6.7%
Saturated Fat 1.1 g5.4%
Trans Fat 0 g
Cholesterol 106.3 mg35.4%
Sodium 245.6 mg10.2%
Total Carbohydrates 33 g11.1%
Dietary Fiber 10 g40.2%
Sugars 8.5 g
Protein 10 g19.8%
Vitamin A 3.1%
Vitamin C 64.6%
Calcium 11.2%
Iron 11.1%
*Based on a 2000 Calorie diet


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The goal of the University of Zimbabwe-University of California San Francisco Clinical Trials Unit (UZ-UCSF CTU) is to provide scientific leadership, a well organized and efficient research-support infrastructure, and even high-capacity Clinical Research Sites (CRS) to conduct state-of-the-art HIV/AIDS prevention and treatment intervention trials in Zimbabwe, with potential application throughout southern Africa and other highly affected regions. Currently there are three research programs in Zimbabwe that participate in DAIDS network activities: 1) UZ-UCSF HIV Prevention Trials Unit (HPTN funding);2) the UZ-Clinical Research Centre (ACTG and HPTN funding);and 3) the UZ Pediatric AIDS Clinical Trials Unit (PACTG funding), each with well-established CRS. We propose to integrate the three programs and seven of their CRS to continue implementation of 12 transitional protocols (HPTN 035, 046, 052;ACTG A5175, A5199, A5221, A5208, A5225;and PACTG A5190/P1054), and to conduct future trials affiliated with four DAIDS networks;the Adult Clinical Trials Group (ACTG), HIV Prevention Trials Network (HPTN), the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT), and Microbicides Trial Network (MTN). Our CTU brings together many of the world's leading researchers from the finest research and public health institutions around the world.
The specific aims i n this proposal are to:
Aim 1. Develop an integrative Clinical Trials Unit by consolidating three existing research programs into a centralized infrastructure to implement existing transitional protocols associated with four DAIDS Clinical Trials Leadership Groups, and to expand our scientific and logistical capacity to participate in future trials. Objective 1 .a. Provide scientific leadership that promotes high quality research, contributes to priority research areas, oversees capable and productive CRS and supports the development of new researchers. Objective 1 .b. Develop centralized research support components to coordinate fiscal management, quality assurance and control, regulatory, human subjects and ethics, data management, laboratory, pharmacy, training, community advisory board liaison, and counseling functions for all UZ-UCSF CTU activities. Objective 1 .c. Strengthen our management and communication systems to ensure high quality research implementation and effective oversight of the seven proposed CRS. Objective 1 .d. Manage transition of clinical protocols from current awards to the proposed CTU structure.
Aim 2. Contribute scientifically to the leadership and prioritization of research activities in four networks: ACTG, HPTN, IMPAACT, and MTN.
Aim 3. Achieve meaningful community partnership in the CTU clinical research activities through effective outreach and communication and Community Advisory Board (CAB) participation.
Aim 4. Work with established clinical research sites that have proven capacity, experience and a record of scientific productivity. ADMINISTRATIVE COMPONENT:
|Fowler, Mary Glenn; Coovadia, Hoosen; Herron, Casey M et al. (2014) Efficacy and safety of an extended nevirapine regimen in infants of breastfeeding mothers with HIV-1 infection for prevention of HIV-1 transmission (HPTN 046): 18-month results of a randomized, double-blind, placebo-controlled trial. J Acquir Immune Defic Syndr 65:366-74
|Sarnquist, Clea C; Moyo, Precious; Stranix-Chibanda, Lynda et al. (2014) Integrating family planning and prevention of mother to child HIV transmission in Zimbabwe. Contraception 89:209-14
|Grinsztejn, Beatriz; Hosseinipour, Mina C; Ribaudo, Heather J et al. (2014) Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. Lancet Infect Dis 14:281-90
|Balkus, Jennifer E; Richardson, Barbra A; Rabe, Lorna K et al. (2014) Bacterial vaginosis and the risk of trichomonas vaginalis acquisition among HIV-1-negative women. Sex Transm Dis 41:123-8
|Borok, Margaret Z; Busakhala, Naftali; Makadzange, Tariro et al. (2014) Setting the research agenda in a resource-limited setting--viewpoint. J Acquir Immune Defic Syndr 65 Suppl 1:S3-4
|Touzard Romo, F; Smeaton, L M; Campbell, T B et al. (2014) Renal and metabolic toxicities following initiation of HIV-1 treatment regimen in a diverse, multinational setting: a focused safety analysis of ACTG PEARLS (A5175). HIV Clin Trials 15:246-60


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The benefits and costs of strong patent protection: a contribution to the current debate
No abstract is available for this item.
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Volume (Year): 27 (1998)
Issue (Month): 3 (July)
Pages: 273-284
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| Web page: http://www.elsevier.com/locate/respol
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Richard Gilbert & Carl Shapiro, 1990.
"Optimal Patent Length and Breadth,"
RAND Journal of Economics,
The RAND Corporation, vol. 21(1), pages 106-112, Spring.
- Gilbert, R. & Shapiro, C., 1988. "Optimal Patent Length And Breadth," Papers 28, Princeton, Woodrow Wilson School - Discussion Paper.
- Richard Gilbert and Carl Shapiro., 1989. "Optimal Patent Length and Breadth," Economics Working Papers 89-102, University of California at Berkeley.
- Teece, David J., 1993.
"Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy,"
Research Policy,
Elsevier, vol. 22(2), pages 112-113, April.
- Teece, David J., 1986. "Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy," Research Policy, Elsevier, vol. 15(6), pages 285-305, December.
- Richard C. Levin & Alvin K. Klevorick & Richard R. Nelson & Sidney G. Winter, 1987. "Appropriating the Returns from Industrial Research and Development," Brookings Papers on Economic Activity, Economic Studies Program, The Brookings Institution, vol. 18(3), pages 783-832.
- Kenneth Arrow, 1962. "Economic Welfare and the Allocation of Resources for Invention," NBER Chapters, in: The Rate and Direction of Inventive Activity: Economic and Social Factors, pages 609-626 National Bureau of Economic Research, Inc.
- Dasgupta, Partha & Stiglitz, Joseph, 1980. "Industrial Structure and the Nature of Innovative Activity," Economic Journal, Royal Economic Society, vol. 90(358), pages 266-93, June.
- Klemperer, Paul, 1990.
"How Broad Should the Scope of Patent Protection Be?,"
CEPR Discussion Papers
392, C.E.P.R. Discussion Papers.
- Paul Klemperer, 1990. "How Broad Should the Scope of Patent Protection Be?," RAND Journal of Economics, The RAND Corporation, vol. 21(1), pages 113-130, Spring.
- Glenn C. Loury, 1979.
"Market Structure and Innovation,"
The Quarterly Journal of Economics,
Oxford University Press, vol. 93(3), pages 395-410.
- Glenn C. Loury, 1976. "Market Structure and Innovation," Discussion Papers 256, Northwestern University, Center for Mathematical Studies in Economics and Management Science.
- Edwin Mansfield, 1986. "Patents and Innovation: An Empirical Study," Management Science, INFORMS, vol. 32(2), pages 173-181, February.
- Caves, Richard E & Crookell, Harold & Killing, J Peter, 1983. "The Imperfect Market for Technology Licenses," Oxford Bulletin of Economics and Statistics, Department of Economics, University of Oxford, vol. 45(3), pages 249-267, August.
- Suzanne Scotchmer & Jerry Green, 1990. "Novelty and Disclosure in Patent Law," RAND Journal of Economics, The RAND Corporation, vol. 21(1), pages 131-146, Spring.
- Kitch, Edmund W, 1977. "The Nature and Function of the Patent System," Journal of Law and Economics, University of Chicago Press, vol. 20(2), pages 265-290, October.
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Dale Hancock, Ph.D.
Dr. Dale Hancock
3540 Clemmons Road Suite 233, Clemmons, North Carolina 27012
The family is the foundation of our society. It is so easy, however, for the family unit to lose focus and fall into a myriad of problems. Sometimes the need is to involve the whole family in counseling to understand the unique dynamics that each member brings. Today there also has to be strong focus on blended families since it is quite prevalent in our society.
Maria Russell, LPC
Licensed Professional Counselor
Salisbury, North Carolina 28146
Families provide a unique complexity of dynamics and relationships. Different personalities, families of origin and opinions/perspectives often lead to conflict among two or more members within the family. While there may be one "identified client", it is important to work together as a system to make changes and grow. I work with families on communication skills, conflict resolution and becoming more aware of how their behaviors effect others around them.
Jill White-Huffman, LPC, MFT
Licensened Professional Counselor, Marriage & Family Therapist
1921 D Boulevard Street / Holden Executive Center, Greensboro, North Carolina 27407
Family Therapy usually consists of learning healthy ways to communicate so that problem solving becomes much easier. In my practice, I have been able to help family members improve their understanding of one another by simply offering helpful strategies that have been researched over time and have been founded to be helpful. Family members learn that if things are not going well within the family dynamics that it is not only important but healthy to get help from a professional so that they learn skills to communicate with one another better. Parents learn ways to model healthy communication patterns with their children and their children will model these same patterns in the future.
Juan Santos, M.S., CRC, LPC
Licensed Counselor
3300 Battleground Avenue Suite 303, Greensboro, North Carolina 27410
My strength and focus when working with your family is to hear what the problem is and provide you with a solution that your family can benefit from. When working with families, I understand that their are many voices wanting to be heard and different personalities clashing. That is why - I work to help each involved family member with tools and strategies on how to manage their areas of concern and that of the whole family. Give me a call today to explore what it is that may be impacting your family and how I can help. I understand that the process of "shopping" for a counselor is lengthy - difficult - and a bit scary --- but so is the alternative of continuing on.


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This pretty popover style blouse from Fat Face boasts a feminine Peter Pan collar and button neck. Crafted from brushed cotton, the shirt is cut to a relaxed fit with rolled 3/4 length sleeves.
Thank you for visiting Fat Face Buffalo Check Popover Shirt, Multi on shoppingfind.co.uk
We bring the products from many websites to one website for you to search, save and compare.


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Hotel Boquier
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Travel Blogs from Avignon
Day 72 - Avignon of Popes and Palaces
... to the village. We strolled the route from our gite (rental) through town, past the church, bakeries, small shops and the mayor's office and a small open air market where we bought some fresh goat cheese. The walk took an hour.
We returned to the rental and got ready for a tour of Avignon. It took about twenty minutes to drive to the train station parking lot where we parked while we toured. We strolled to the North through town to the Palais des Papes. Avignon was the ...
Day 71 - Provence Provincial
... a hundred years old. Check out the photos on the website of our cottage as we have no photos today. This location would be great for a family gathering, albeit a bit far to go.
http://www.moulindelaroque.com/la-roque -villa-maison-du-meunier-en.htm
After settling our things in the cottage, we headed to a nearby village for an exciting afternoon of ....laundry. Yes, since ...
Avignon and Pont du Gard
... the mountains in the distance. Next on our journey we stopped outside of the Palais des Papes and the church right next to it. The Palais des Papes was constructed in the 13th century and housed six Papal Conclaves. We also found a Cathedral near the Palais and the forum with extremely well-preserved, intricately designed wooden doors dating back to the same time period. ...
DAY 24 (Sunday) "Daytripper"
... important town on the road to Spain. Most to the aqueduct was on or even under the ground but whenever it needed to span a river, they built a bridge. In this case a very large bridge.
At each town, they dropped us off at a meeting place and we had 30-45 minutes to explore on our own. This was nice because we didn't have to always be with a group or hear ...
... of the train staff (a common theme I'm finding across Europe) I missed the train which was leaving in 10 mins and had to wait an additional half an hour to reach the town. So my start was not a good one.
But finally I found them!! And we enjoy a lovely lunch at a small restaurant. The centre of Avignon, known as the city of Popes, is a UNESCO protected area. It's like stepping back into a different time. We walk all around the centre, up to the ...


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This apartment is rent subsidized by the Florida Housing Finance Corporation. Currently Sherwood Apartments has 33 subsidized apartments out of a total of 33 apartments. Occupancy status: Ready for Occupancy. The apartment is rent subsidized by the US Department of Agriculture Rural Development. There are 32 one bedroom apartments at Sherwood Apartments. Housing program available: Housing Credits 9% | Rental Assistance RD | Section 515.
Note: Apartments may not have openings or may have long waiting lists. Call for complete details.


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Feb 10, 2014 at 5:20 pm | Print View
One University of Iowa researcher says theĀhuman brain is limited to what it can focus on andĀscience shows drivingĀwhile doing other activitiesĀpulls the driver's mind away from the road.
Shaun Vecera, a UI psychology professor and researcher, told a Senate Transportation Committee the brain cannot focus on everything at once meaning humans fall prey to selective attention, where an event or object goes unnoticed as the brain is focused on something else. This "inattentional blindness" means although something occurs it can go unnoticed by someone focusing on something else.ĀVecera said thisĀcognitive limitationĀmeans drivingĀwhile talking on the cell phone "hasĀserious implications forĀdriving behavior" and greatly increasesĀthe chances of an accident.ĀPublic safety officials say distracted driving is a growing concern and have pushed for ways to better enforce state driving laws. Following the presentation, Chairman Sen. Tod Bowman, D-Maquoketa, said it's concerning all of the distractions Iowa drivers face on the road. He said it's important that drivers and legislators understand the science that no one is immune to how the brain responds when distracted.
Current law bars drivers from texting while driving and teenagers from using a cell phone to talk or text while driving under with a restricted or intermediate license.
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Hey guys, I had to really scrape around lately to find some good art, it was a chore, but I found some stuff today that's pretty good. A few original characters coming so keep an eye out for that! I'd also like to apologize for this being later than I usually do, things have been a little backed up, so this was a bit late.
Okay, I'm sure you're wondering what this one is doing here, well, photography is art after all and I find this to be really cool and quite smart. Commander Cody leading the way to repairing and preparing the camera! Now the question is, if that's the camera, how was the picture taken!?
Passage au numrique by ERBK on Deviant Art
ORIGINAL CHARACTERS! Okay, this one brightened things up, my search through art was pretty antagonizing this time around, and it's always fun to get the stand out, just the characters hanging out or goofing around, it's refreshing. It's sad that they are so few and far between.
Padawans, Padawans Everywhere. by MonochromeAgent on Deviant Art
This one that got plugged to me on twitter and I was SO not disappointed by this!it's really cool, very life-like! I'm just amazed by the detailing of this, I really don't know what to say, it just amazes me. I really hope to see more stuff from you Liam and it was great to get this from you.
Chewbaca by Liam Nicholson
Here is a nifty looking cartoon stylized Yoda. This was a neat one, I thought this was a great showing of Yoda, the surroundings are pretty cool too, it's a complete picture and I had almost not noticed he was levitating on the cushion when I first looked at the picture!
Yoda by AndrewMcIntoshArt on Deviant Art
A cool inking which was colored in photoshop, it's just a straight up, bad ass picture of a Tusken Raider. It reminds me of a samurai, I dunno what it is, just, I seem a samurai standing there in the wrappings of a tusken raider and it is what has me loving this picture!
Tusken Raider by Neoncypher on Deviant Art
Darth Maul, probably everyone's favorite sith, (thanks Lucas arts for ruining him in the episode of clone wars last week,) I like the realism in this picture, very nicely done. One of my favorite things about this picture is the lighting, it gives a nice feel to the picture.
Darth Maul by SereNNa666 on Deviant Art
Okay, this is another original character, it's pretty bad ass looking. I cannot help but wonder what that sphere is spinning there, is it just something to show use of the force, maybe some sort of sith relic, or maybe something sentimental to the character? Who knows at this rate, either way, it's an awesome picture, she looks like a sith I wouldn't want to cross.
Sith Happens by medders On Deviant Art
Well, that's everything, sorry about the cut in content I again I had to scrape for this stuff, anyway, Ihope you guys and gals enjoyed the art, I know I did!
And as always...
I'd appreciate some help and guidance on where to go and things I should see that may deserve a posting, E-Mail me a link at email@example.com or tweet me @PoweroftheFans with #ThePoweroftheFans and it will probably see it's day in the sun. Doesn't matter if it's by you, a friend, or a complete stranger who makes things you like. Just make sure it links to the customizer's/art's post/site/submission, as I would prefer to credit the customizer/artist.
Thanks guys,
Related Fly Posts
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From Milla's Catster Photos[ View profile page ]
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Hi Milla, you have a very sweet face and gorgeous eyes!
Your cat loves a clean toilet -- don't we all? Catster's singing Cat Lady, Sarah Donner, explains why.24
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