text:
Effect of mode of hydrocortisone administration on glycemic control in patients with septic shock: a prospective randomized trial
DOI: 10.1186/cc5696
© Loisa et al.; licensee BioMed Central Ltd 2007
Received: 18 October 2006
Accepted: 16 February 2007
Published: 16 February 2007
Low-dose hydrocortisone treatment is widely accepted therapy for the treatment of vasopressor-dependent septic shock. The question of whether corticosteroids should be given to septic shock patients by continuous or by bolus infusion is still unanswered. Hydrocortisone induces hyperglycemia and it is possible that continuous hydrocortisone infusion would reduce the fluctuations in blood glucose levels and that tight blood glucose control could be better achieved with this approach.
In this prospective randomized study, we compared the blood glucose profiles, insulin requirements, amount of nursing workload needed, and shock reversal in 48 septic shock patients who received hydrocortisone treatment either by bolus or by continuous infusion with equivalent dose (200 mg/day). Duration of hydrocortisone treatment was five days.
The mean blood glucose levels were similar in the two groups, but the number of hyperglycemic episodes was significantly higher in those patients who received bolus therapy (15.7 ± 8.5 versus 10.5 ± 8.6 episodes per patient, p = 0.039). Also, more changes in insulin infusion rate were needed to maintain strict normoglycemia in the bolus group (4.7 ± 2.2 versus 3.4 ± 1.9 adjustments per patient per day, p = 0.038). Hypoglycemic episodes were rare in both groups. No difference was seen in shock reversal.
Strict normoglycemia is more easily achieved if the hydrocortisone therapy is given to septic shock patients by continuous infusion. This approach also reduces nursing workload needed to maintain tight blood glucose control.
Trial Registration Number
Surviving sepsis guidelines recommend low-dose corticosteroids for the treatment of vasopressor-dependent septic shock [1]. In prospective randomized trials, hydrocortisone therapy has shown a significant effect in septic shock reversal [2, 3], and in one large prospective study, a treatment with a hydrocortisone-fludrocortisone combination also reduced mortality in the subgroup of patients who had a poor adrenal response in the adrenocorticotrophic hormone stimulation test [4]. The recommended hydrocortisone dosage is 200 to 300 mg daily in three or four divided doses. Alternatively, hydrocortisone may be administered by continuous infusion [5].
The tolerability of hydrocortisone therapy has been good in previous studies and there is no evidence that corticosteroids have increased the risk of gastrointestinal bleeding or risk of secondary infections when used in septic shock [4, 6]. However, hydrocortisone is a potent glucocorticoid and it stimulates gluconeogenesis in both liver and peripheral tissues. It is possible that corticosteroid treatment may induce hyperglycemia and that the frequency of insulin use may increase with corticosteroid exposure [7]. These effects must also be considered as major adverse events in critically ill patients. Impaired glycemic control has been associated with increased mortality in a heterogeneous population of critically ill patients [8], and van den Berghe and coworkers [9] showed that preventing hyperglycemia with insulin substantially improved outcome in critically ill surgical patients. This survival benefit was also observed in a recent prospective study in a medical intensive care unit (ICU) population that required ICU treatment for more than three days [10]. In addition, corticosteroids may increase the risk of critical illness polyneuropathy and myopathy, and therefore the use of corticosteroids may be associated with protracted weaning from mechanical ventilation [7, 11]. Prolonged hyperglycemia is one possible pathophysiologic mechanism behind these complications [12].
So far, no studies have compared bolus versus continuous hydrocortisone infusion regimen and their effects to blood glucose profiles in septic shock [2, 13]. International guidelines do not precisely indicate which treatment modality would be better [5]. The hypothesis of this study was that continuous hydrocortisone infusion would reduce the occurrence of hyperglycemic and hypoglycemic episodes when compared to conventional bolus treatment. The purposes of this study were to investigate how the different corticosteroid treatment modalities would influence glucose profiles in septic shock and to compare the reversal of shock and nursing workload needed between two different hydrocortisone regimens.
Materials and methods
This prospective study was conducted between July 2005 and April 2006 in the ICUs of Kuopio University Hospital (Kuopio, Finland), Tampere University Hospital (Tampere, Finland), South Carelian Central Hospital (Lappeenranta, Finland), and Päijät-Häme Central Hospital (Lahti, Finland). The study protocol was approved by the local ethics committees, and informed consent was obtained from the patients or their first-degree relatives.
Patients were prospectively enrolled in the study if they met the criteria for septic shock defined according to the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: (a) the presence of systemic inflammatory response syndrome (manifested by two or more of the following criteria: fever [temperature of more than 38°C] or hypothermia [temperature of less than 35.5°C], tachycardia [more than 90 beats per minute], tachypnea [more than 20 breaths per minute], and leukocytosis or leukopenia [white blood cell count of more than 12,000/mm3 or less than 4,000/mm3, respectively]), (b) documented source of infection, and (c) hypotension despite adequate fluid resuscitation (systolic blood pressure of less than 90 mm Hg or a decrease of systolic blood pressure by 40 mm Hg or more from the baseline) [14]. In addition, patients had to receive norepinephrine at any dose to maintain mean arterial blood pressure above 65 mm Hg. Patients under 18 years of age, patients with pre-existing diabetes, and patients receiving glucocorticoids were excluded from the study. Also, patients who died within 24 hours after the randomization were excluded from the analysis. APACHE (Acute Physiology and Chronic Health Evaluation) II score [15] and SAPS (Simplified Acute Physiology Score) II [16] were calculated and the severity of organ dysfunction was assessed using SOFA (Sepsis-related Organ Failure Assessment) score [17] at the time of ICU admission. Hemodynamic variables were recorded with arterial and Swan-Ganz catheters. A pulmonary artery catheter was used in 42 (88%) patients on the basis of clinical judgment.
Study intervention
When patients were considered to benefit from the corticosteroid treatment, they were randomly assigned to receive hydrocortisone either by a conventional bolus therapy (50-mg bolus of hydrocortisone every six hours intravenously) or by continuous infusion with equivalent dose (200 mg/day). Hydrocortisone treatment was started according to clinical judgment when patients required high-dose or increasing norepinephrine support [18]. Hydrocortisone was given in hydrocortisone sodium succinate (Solu-Cortef®; Pharmacia, now part of Pfizer Inc, Täby, Sweden), and when continuous infusion was used, hydrocortisone was diluted in physiologic saline. Randomization was performed in groups of four patients by means of sequentially numbered opaque envelopes. The duration of hydrocortisone treatment was five days.
Algorithm for glucose control in the study
Initial infusion
Blood glucose
Insulin infusion rate
Control interval
1 IU/hour
2 IU/hour
> 12
> 215
4 IU/hour
Maintenance infusion
Blood glucose
Insulin infusion rate
Control interval
< 2.5
< 45
10 % glucose 150 ml iv..
< 3.0
< 54
Stop insulin
Reduce insulin dose by half
Reduce by 0.5 IU/hour
Insulin dose unchanged
Increase by 0.5–1 IU/hour
Increase by 1 IU/hour
> 12.0
> 215
Increase by 2 IU/hour
Sample size and statistical analysis
A sample size was calculated on the basis of detecting a difference of 1 mmol/l in mean blood glucose levels between the study groups. A standard deviation (SD) of 1 mmol/l in blood glucose level was assumed when calculating a sample size based on previous studies [9]. A minimum of 17 patients were required in each group (α = 0.05, power = 80%). ICU mortality was expected to be 30% and therefore 24 patients were randomly assigned in both groups. Results are reported as mean ± SD. Descriptive data were analyzed using the unpaired t test for the continuous variables, and the categorical data were analysed using a χ2 test. Blood glucose profiles, insulin requirements, and serial hemodynamic data were compared with the analysis of variance for repeated measurements. Kaplan-Meier curves were calculated for shock reversal, and the comparison between the groups was performed with the log-rank test. All randomly assigned patients were included for mortality and shock reversal analysis, and the patients who died due to refractory hypotension during the study period were considered as not having reversed septic shock. A p value of less than 0.05 was considered significant. Statistical analysis was performed using the SPSS 13.0 version (SPSS Inc., Chicago, IL, USA).
The primary endpoint in the study was the difference in the mean blood glucose levels between the study groups and the occurrence of hyper- and hypoglycemic episodes. Secondary endpoints included the reversal of shock and the amount of nursing workload required to maintain strict normoglycemia. The nursing workload was estimated by recording the number of adjustments in insulin infusion during the study period. Hyperglycemia was defined as a blood glucose level of more than 7 mmol/l (126 mg/dl) and severe hyperglycemia as a blood glucose level of more than 8.3 mmol/l (150 mg/dl) [19]. Hypoglycemia was defined as a blood glucose level of less than 3 mmol/l (54 mg/dl) and severe hypoglycemia as a blood glucose level of less than 2.2 mmol/l (40 mg/dl) [9]. Reversal of shock was defined as a stable mean arterial pressure of more than 65 mm Hg for at least 24 hours without norepinephrine support.
Patient characteristics in the study
Bolus group (n = 23)
Infusion group (n = 22)
p value
Age (years)
61 ± 17
60 ± 16
APACHE II score
22.7 ± 5.6
22.5 ± 7.9
51.5 ± 11.3
52.2 ± 14.6
SOFA score
10.0 ± 2.1
10.3 ± 2.4
PaO2/FiO2 ratio (mm Hg)
193 ± 110
176 ± 75
Cardiac index (l/minute per m2)
3.8 ± 1.7
3.6 ± 1.5
Mean arterial pressure (mm Hg)
62 ± 7.5
65 ± 7.9
Systemic vascular resistance (dyn·s/cm5)
623 ± 221
731 ± 254
SvO2 (percentage)
61 ± 7.6
64 ± 12
Hemoglobin (g/l)
106 ± 22
105 ± 19
Leukocyte count (109/l)
14.1 ± 9.2
9.6 ± 7.7
Platelet count (109/l)
180 ± 103
141 ± 92
Plasma C-reactive protein (mg/l)
223 ± 115
197 ± 99
Serum lactate (mmol/l)
2.3 ± 1.6
2.8 ± 1.9
Norepinephrine dose (μg/kg per minute)
0.22 ± 0.12
0.19 ± 0.16
ICU mortality, n (percentage)
4 (17%)
7 (29%)
Glycemic control in study groups
Bolus group (n = 23)
Infusion group (n = 22)
p value
Mean blood glucose (mmol/l)
6.4 ± 0.7
6.2 ± 0.7
Blood glucose variation coefficient (percentage)
20.2 ± 6.9
16.5 ± 4.8
Blood glucose > 7 mmol/l (episodes per patient)
15.7 ± 8.5
10.5 ± 8.6
Blood glucose > 8.3 mmol/l (episodes per patient)
3.6 ± 3.4
2.6 ± 3.2
Mean insulin dose (IU/day)
66 ± 43
61 ± 40
Insulin infusion adjustments (number per patient per day)
4.7 ± 2.2
3.4 ± 1.9
Blood glucose < 3 mmol/l (episodes per group)
3 (13%)
1 (4.5%)
Blood glucose < 2.2 mmol/l (episodes per group)
Hemodynamic parameters in study groups
Day 1
Day 2
Day 3
Day 4
Day 5
p value
Heart rate (beats per minute)
Bolus group
107 ± 20
93 ± 20
85 ± 20
78 ± 22
86 ± 21
Infusion group
100 ± 21
95 ± 19
87 ± 23
86 ± 22
83 ± 15
Mean arterial pressure (mm Hg)
Bolus group
62 ± 7.5
75 ± 12
79 ± 13
85 ± 15
87 ± 15
Infusion group
65 ± 7.9
72 ± 9.4
72 ± 12
75 ± 13
79 ± 19
Cardiac index (liters/minute per m2)
Bolus group
3.8 ± 1.7
3.5 ± 1.1
3.5 ± 0.9
3.4 ± 1.0
3.4 ± 0.7
Infusion group
3.6 ± 1.5
3.9 ± 1.3
3.5 ± 1.1
3.6 ± 1.3
3.8 ± 1.5
SvO2 (percentage)
Bolus group
61 ± 7.6
67 ± 7.2
69 ± 7.3
70 ± 7.6
69 ± 7.0
Infusion group
64 ± 12
65 ± 10
63 ± 11
66 ± 13
70 ± 13
SVR (dyn·s/cm5)
Bolus group
623 ± 221
770 ± 323
861 ± 249
999 ± 334
1,061 ± 200
Infusion group
731 ± 254
705 ± 248
818 ± 274
836 ± 332
832 ± 214
Shock reversal, n (percentage)
Bolus group
0/24 (0%)
3/24 (13%)
14/24 (58%)
18/24 (75%)
20/24 (83%)
Infusion group
0/24 (0%)
5/24 (21%)
12/24 (50%)
14/24 (58%)
15/24 (63%)
The main findings in the present study were that the hyperglycemic episodes were more common in those patients who received hydrocortisone in bolus therapy and that the amount of nursing workload needed to maintain normoglycemia was higher in bolus-treated patients. Our findings suggest that, in septic shock, strict normoglycemia is more easily achieved with continuous hydrocortisone infusion. However, the differences between the study groups were rather marginal and in both groups the normoglycemic goal could be achieved quite successfully.
The most important risk associated with intensive insulin therapy is the occurrence of severe hypoglycemia. This risk seems especially likely to increase if the target range for the glucose control is set at 4.4 to 6.1 mmol/l (80 to 110 mg/dl). In the study of van den Berghe and coworkers [10], severe hypoglycemic episodes (less than 2.2 mmol/l [40 mg/dl]) were observed in 25% of the long-stay ICU patients, and more importantly, hypoglycemic episodes were associated with increased mortality. In severely ill ICU patients, this risk seems to be higher than in postoperative patients, and patients with sepsis are especially vulnerable to hypoglycemia [10, 20, 21]. In our study, only four episodes (8.8%) of hypoglycemia (blood glucose of less than 3 mmol/l [54 mg/dl]) were detected, and more importantly, no severe hypoglycemic (less than 2.2 mmol/l [40 mg/dl]) episodes were observed in either study group. These findings suggest that even a slightly more liberal glucose control will prevent dangerous hypoglycemic episodes very effectively. Other authors have also suggested that blood glucose control might be somewhat more liberal than in the study of van den Berghe and coworkers [22].
Certain limitations of this study should be addressed. The study was not placebo-controlled or blinded. The major limitation in our study was that the nutritional support in individual patients was rather heterogeneous despite the unambiguous feeding protocol. The majority of the study patients had septic shock due to gastrointestinal primary disease (gastrointestinal perforation or acute pancreatitis) and in these patients the enteral feeding could not always be increased according to the study protocol. In four patients (two in both groups), parenteral nutrition was initiated during the study because enteral feeding was not possible. In 16 patients, the maximum intake of calories remained below 15 kcal/kg per day, and in eight patients this underfeeding was due to the problems associated with enteral nutrition. Additionally, nutritional goals were not achieved in eight patients because they either died or were discharged to the general ward before the completion of the five day study period. The remaining eight patients received poor nutrition because they either died or were discharged to the general ward before the study period was completed. However, in those patients who stayed in the ICU for the entire study period, the nutritional goals were achieved quite successfully: the mean intake of calories in these patients was 19.0 ± 6.0 kcal/kg per day with no detectable differences between study groups. The standardization of nutritional support has also been difficult in other trials concerning critically ill patients [23].
Continuous hydrocortisone infusion reduced the number of hyperglycemic episodes, and this approach also reduced the nursing workload during intensive insulin therapy. Strict normoglycemia is more easily achieved if hydrocortisone therapy is given to septic shock patients by continuous infusion.
Key messages
In septic shock, continuous hydrocortisone infusion will reduce the number of hyperglycemic episodes during intensive insulin therapy.
Continuous hydrocortisone infusion will also reduce the nursing workload needed to maintain tight blood glucose control.
ICU = intensive care unit
SD = standard deviation.
This study was supported by the Medical Research Fund of Tampere University Hospital, Tampere, Finland, and the Medical Research Fund of Päijät-Häme Central Hospital, Lahti, Finland.
Authors' Affiliations
- Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, et al.: Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 2004, 30: 536-555. 10.1007/s00134-004-2398-yView ArticlePubMedGoogle Scholar
- Bollaert PE, Charpentier C, Levy B, Depouverie M, Audibert G, Larcan A: Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998, 26: 645-650. 10.1097/00003246-199804000-00010View ArticlePubMedGoogle Scholar
- Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, et al.: Stress doses of hydrocortisone reverses hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 1999, 27: 723-732. 10.1097/00003246-199904000-00025View ArticlePubMedGoogle Scholar
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- Rady MY, Johnson DJ, Patel B, Larson J, Helmers R: Corticosteroids influence the mortality and morbidity of acute critical illness. Crit Care 2006, 10: R101. 10.1186/cc4971PubMed CentralView ArticlePubMedGoogle Scholar
- Krinsley JS: Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003, 78: 1471-1478.View ArticlePubMedGoogle Scholar
- van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345: 1359-1367. 10.1056/NEJMoa011300View ArticlePubMedGoogle Scholar
- van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354: 449-461. 10.1056/NEJMoa052521View ArticlePubMedGoogle Scholar
- De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, Cerf C, Renaud E, Mesrati F, Carlet J, et al.: Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002, 288: 2859-2867. 10.1001/jama.288.22.2859View ArticlePubMedGoogle Scholar
- Bercker S, Weber-Carstens S, Deja M, Grim C, Wolf S, Behse F, Busch T, Falke KJ, Kaisers U: Critical illness polyneuropathy and myopathy in patients with acute respiratory distress syndrome. Crit Care Med 2005, 33: 711-715. 10.1097/01.CCM.0000157969.46388.A2View ArticlePubMedGoogle Scholar
- Oppert M, Schindler R, Husung C, Offermann K, Graf KJ, Boenisch O, Barckow D, Frei U, Eckardt KU: Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005, 33: 2457-2464. 10.1097/01.CCM.0000186370.78639.23View ArticlePubMedGoogle Scholar
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- Viresendorp TM, van Santen S, DeVries JH, de Jonge E, Rosendaal FR, Schultz MJ, Hoekstra JB: Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med 2006, 34: 96-101. 10.1097/01.CCM.0000194536.89694.06View ArticleGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Against Technology
From the Luddites to Neo-Luddism
By (author) Steven E. Jones
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Against Technology by Steven E. Jones
Book DescriptionThis book addresses the question of what it might mean today to be a Luddite--that is, to take a stand against technology. Steven Jones here explains the history of the Luddites, British textile works who, from around 1811, proclaimed themselves followers of "Ned Ludd" and smashed machinery they saw as threatening their trade. Against Technology is not a history of the Luddites, but a history of an idea: how the activities of a group of British workers in Yorkshire and Nottinghamshire came to stand for a global anti-technology philosophy, and how an anonymous collective movement came to be identified with an individualistic personal conviction. Angry textile workers in the early nineteenth century became romantic symbols of a desire for a simple life--certainly not the original goal of the actions for which they became famous. Against Technology is, in other words, a book about representations, about the image and the myth of the Luddites and how that myth was transformed over time into modern neo-Luddism.
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Book DetailsISBN: 9780415978682
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Pages: 288
Imprint: Routledge
Publisher: Taylor & Francis Ltd
Publish Date: 9-Jun-2006
Country of Publication: United Kingdom
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Blue Eagle Meets Double Trouble, Hardback (September 2008)
Peaceful Valley is a haven where the critters roam freely. The tranquility is disrupted when Blue Eagle departs to his brother's land and the coyotes, Clem and Clod - bent on taking advantage of the creatures - charge into the valley. In the absence of their protector, the animals try to figure out how to deal with the wily twosome on their own.
Meaning of Video Games, Paperback (April 2008)» View all books by Steven E. Jones
Explores the ways in which textual studies concepts - authorial intention, the paratext, publishing history and the social text - can shed light on video games as more than formal systems. This book treats video games as cultural forms of expression that are received as they are played, out in the world, where their meanings get made.
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Author Biography - Steven E. Jones
Steven E. Jones is Professor of English at Loyola University, Chicago. He is author of Satire and Romanticism and editor of The Satiric Eye.
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Aeria Games = Areola Games.
I appreciate the post, but this is just one of those games where it doesn't matter what anyone says. It can be the deepest and most complex / well-written post... the only things that will ever be talked about are boobs.
Originally posted by Dauzqul
Aeria Games = Areola Games
Conqest of the Nipple Mountain?
Aeria's idea of PVP = Perkyboobs vs Perkyboobs
the best way to kill a troll is to FLAME ON! ...or with acid...
Originally posted by Archid
All about BVB...
Better than DVD....
Oh well to each his taste.
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Gee, thanks Japan. I last expected Queen's Blade to actually migrate medias to MMO.
Considering that in this world praying to god involves many sexual positions, I'd say this is in fact a mirror universe with strong females and what's conservative and what's not is laterally inverted.


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SW-MOTECH Bags-Connection Blaze Sport Saddlebag System for BMW F800GT '13-'17 & F800R '09-'14$400.95


text:
More Videos...
Russian Police Kill a Pit bull WARNING *Graphic*
Bank Robbers Shooting at Cops
Racing and car crash fan? Subscribe to http://link.base79.com/polepositionsub Pole Position is the place for motor sport fans and petrol heads covering the very best races, teams and drivers from around the world. From F1 to banger racing and from Indianapolis to Monte Carlo we'll cover the best of the best, keeping you entertained. Highlights, interviews, team tours and on location we'll be there to give you the inside track. Follow on Twitter: http://goo.gl/fyE5O Like on Facebook: http://goo.gl/d15Mv +1 on Google+: http://goo.gl/B7PU4 This clip has to be seen to be believed. An officer keeps chasing a suspected criminal despite having a shootout.
Crazy firefight on pursuit (Russian police vs BMW X5)
black bmw x5 try to escape. but police car catch him and shoot wheels


text:
Police in Northern Ireland are bracing themselves for a fresh wave of violence today after officers came under sustained attack during riots that again proved that no solution has been found to the parades problem.
As Belfast counts the cost of the latest eruption of violence, officers are preparing for another contested parade in the border village of Castlederg, County Tyrone.
Police described as "mindless anarchy" the activities of loyalist rioters who injured 56 officers on Friday night when half-bricks, pieces of metal and debris flew through the air in Belfast's main shopping street, Royal Avenue.
One of the most striking images of the clashes was that of a semi-conscious policeman stretched out on the street for 30 minutes while colleagues, working under a hail of missiles, administered first aid. Police responded by dousing loyalists with water cannon, firing 26 plastic baton rounds and arresting seven people for offences including riotous behaviour, disorderly behaviour and hijacking.
Today's march, organised by Sinn Fein, has been condemned by local people who claim it will glorify the IRA, which killed almost 30 people in the area during the Troubles. But Sinn Fein has argued that the event, to mark the deaths of two IRA members whose bomb prematurely detonated 40 years ago, is intended as a commemoration, not a celebration.
The marching issue will top the agenda for talks later this year under the chairmanship of the former US diplomat Richard Haass, who has been invited by local parties to tackle issues they have been unable to resolve.
- More about:
- Belfast
- Derby County
- Police


text:
Sarukkai Jagannathan
Sarukkai Jagannathan (b 18 May 1914 - d 1996) was the tenth Governor of the Reserve Bank of India from 16 June 1970 to 19 May 1975.[1]
Educated at the Presidency College, Madras, Jagannathan was a member of the Indian Civil Service, and had served with the Central Government. Prior to becoming the Governor of the RBI, he was India's Executive Director at the World Bank.[2]
The oil shock of the 1970s was re-elected by a very active monetary policy during his tenure. Other achievement include an expansion of banking offices in pursuance of the objectives of the nationalisation of private banks.
The Credit Guarantee Corporation of India, and State Level Bankers' Committees were established during his tenure. Indian Rupee notes of 20 and 50 denomination were introduced, and these bore his signature.[3]
He relinquished office to take up the post of the India's Executive Director at the International Monetary Fund.
- ^ "S Jagannathan". Reserve Bank of India. Retrieved 2008-09-15.
- ^ "List of Governors". Reserve Bank of India. Retrieved 2006-12-08.
- ^ Jain, Manik (2004). 2004 Phila India Paper Money Guide Book. Kolkata: Philatelia. pp. 45, 49.
|This Indian business-related biographical article is a stub. You can help Wikipedia by expanding it.


text:
How to build the Micro storage box:
1. Connect both HDDs to the power and to the Sata adapter
2. lay the HDDs down in the storage
3. put the cooling plates on the HDDs
4. position the power supply unit in front of the first hdd
5. position the two sata to usb adapter with light pressure; the first above the power supplie unit; the second in frot of the second hdd.
6. put the the cover on the storagebox and mount the backpanel.
7. built the remote control unit in the backpanel of your pc.
8. connect the remote control unit to a free molex power connector.
9. connect the storagebox to your pc with 2 usb cable and remote control cable.
writing mode: 34 Watt
After 1h writing:
|Last Updated on Sunday, 30 December 2012 19:26


text:
Baltimore County News
Public Hearing is October 13, 2015
In accordance with the amended Annotated Code of Maryland, Environment Article Section 9-1712, the Baltimore County Department of Public Works is proposing an amendment to Baltimore County's Ten Year Solid Waste Management Plan ("the Plan") regarding the availability of recycling at certain special events.
In order to solicit input from the community, a public hearing is being held on Tuesday, October 13, from 7 to 8:30 p.m. at the Towson Library meeting room, located at 320 York Road in Towson. Representatives from Baltimore County will be present at the hearing to accept comments and answer questions. Further information can be obtained by calling the Bureau of Solid Waste Management at 410-887-2000.
Proposed Plan Available, Submit Comments
Download a copy of the proposed Plan amendment or pick up a hard copy at the office of the Bureau of Solid Waste Management at 111 West Chesapeake Avenue in Towson (County Office Building), and at every branch of the Baltimore County Public Library system.
In addition to the public hearing, people may submit written comments on the proposed amendment to Edward C. Adams Jr., Director, Department of Public Works, 111 West Chesapeake Avenue, Towson, Maryland 21204. Comments must be received within 35 days of the public hearing.


text:
After bug 573733, this is the second part to sync us with Firefox' bug 554005, it makes sense to move over to .tabContainer and instead deprecate .mTabContainer.
Created attachment 456632 [details] [diff] [review]
do the switch
This is easy, esp. as we already support both names, this patch moves the old one to be deprecated in accordance with Firefox.
Pushed as http://hg.mozilla.org/comm-central/rev/9bbc9b44bbf0


text:
Mess Kid
LRG's "The Hustle Treehouse"
If you're familiar with LRG, then you're familiar with their mantra "Hustle Trees." So it's only right that the California-based company celebrate 4/20 in style.
Photo Recap: 5th Annual Brooklyn Electronic Music Festival
When Mass Appeal first previewed the talent for the 5th annual Brooklyn Electronic Music Festival, your ears were treated to their mastery of DJing through…
Tribeca Grand Hotel's Basement Party with BPM LWR LVL
People look good when they party. Here's what the BPM LWR LVL event looks like every other Saturday.


text:
It looks like you're new here. If you want to get involved, click one of these buttons!
MMORPG.com Warhammer Online Correspondent Andrew Bobb writes this guide to combat for the first ten levels of the Magus career in Mythic's RvR game.
The multi role ability of the Magus is shown right from the start with the skills Flickering Red Fire and Daemonic Maw. Flickering Red Fire is a long range elemental damage spell with a two second cast time and no cooldown. Daemonic Maw is a melee range ability that casts instantly and has no cooldown. In addition to dealing damage, Daemonic Maw will cause a hexed target to lose forty percent speed for ten seconds.
Jon Wood
Managing Editor
Although it is one of your worst spells for AP conservation, Demonic Lash can be lethal in the thick of battle. Combined with DOTs you can get top of the table for damage done and killing blows by spamming this spell. It rocks... until some MDPS class clicks onto you then comes and whoops your ass... oh well, fun all the same hehe


text:
Top Definition
When you're so hungry you're willing to rape someone if it means you'll get food afterwards. Other uses; rape thirsty, rape tired, rape bored, etc.
Man, i am rape hungry right now. I would RAPE someone for a hamburger!
by richardbreeeees May 23, 2009
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


text:
Explore Area
Gennemgå eller ændr en nuværende reservation:
Log på for at se alle reservationer på din konto
Enjoy our excellent location near the Fargodome
From the Radisson Fargo, you can explore popular downtown attractions including, shops, restaurants and entertainment thanks to a special climate-controlled skyway pedestrian system. Our hotel's location is also near the Fargodome and the Fargo Civic Center, so you can attend performances and games throughout the year. As an added convenience, our hotel offers complimentary shuttle service to Hector International Airport (FAR), which helps take the stress out of travel.
Popular nearby attractions include:
- Fargo Civic Center (407 feet)
The Fargo Civic Center hosts conferences, trade shows, musical performances, sporting events and more throughout the year.
Phone: +1 (800) 745-3000
- Fargo Theatre (0.2 miles)
Build circa-1926, the Fargo Theatre screens classic films, new release and independent movies throughout the year.
Phone: +1 (701) 239-8385
- Plains Art Museum (0.3 miles)
View paintings, sculptures and photos by regional artists at the Plains Art Museum.
Phone: +1 (701) 232-3821
- Hjemkomst Center (0.7 miles)
The Hjemkomst Center features a replica Viking ship and several cultural exhibits about the Red River Valley.
Phone: +1 (218) 299-5515
- Concordia College (1.1 miles)
Concordia College is a private liberal arts college with more than 2,500 students.
Phone: +1 (218) 299-4000
- North Dakota State University (1.4 miles)
This beautiful 260-acre campus is a well-known research institution.
Phone: +1 (701) 231-8011
- Minnesota State University-Moorhead (1.8 miles)
Minnesota State University-Moorhead is home to more than 7,500 students and the Dragons sports teams.
Phone: +1 (800) 593-7246
- Fargodome (2.5 miles)
The Fargodome hosts conferences, shows and performances throughout the year on the campus of North Dakota State University.
Phone: +1 (701) 241-9100
- Fargo Air Museum (2.7 miles)a
See an impressive collection of historic planes at this museum that is home to the world's only flying Super Corsair.
Phone: +1 (701) 293-8043
- The Children's Museum at Yunker Farm (2.8 miles)
This interactive museum offers fun for kids of all ages.
Phone: +1 (701) 232-6102
- Scheels Arena (3.2 miles)
Scheels Arena hosts exciting live performances and exciting hockey games throughout the year.
Phone: +1 (701) 356-7656
- Red River Zoo (6.5 miles)
See more than 300 animals from around the globe, including red pandas, Bactrian camels and grey foxes at the Red River Zoo.
Phone: +1 (701) 277-9240
- Bonanzaville (10.9 miles)
With more than 43 historic buildings and 400,000 artifacts, Bonanzaville is the perfect place to learn about local culture.
Phone: +1 (701) 282-2822
Nearby Attractions


text:
Curried Sweet Potato Strips
|Sweet potatoes
|1 1⁄2 Pound, peeled (3 Small Ones)
|Vegetable oil
|1 1⁄3 Tablespoon (1 Tablespoon Plus 1 Teaspoon)
|Unsweetened apple juice
|1 Tablespoon
|Curry powder
|1⁄2 Teaspoon
|Vegetable cooking spray
1. Cut each potato lengthwise into 14 thin wedges; place in a large heavy-duty, zip-top plastic bag. Add oil, apple juice, and curry powder to bag. Seal bag, and shake until potato wedges are well coated.
2. Remove wedges from bag, and place in a single layer on a 15- x 10- x 1-inch jellyroll pan coated with cooking spray. Bake at 400° for 45 minutes or until crisp and lightly browned, stirring every 10 minutes. Serve immediately.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 264 Calories from Fat 66
% Daily Value*
Total Fat 7 g11.4%
Saturated Fat 1 g5%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 125.8 mg5.2%
Total Carbohydrates 47 g15.6%
Dietary Fiber 7.1 g28.3%
Sugars 10.1 g
Protein 4 g7.3%
Vitamin A 643.6% Vitamin C 9.2%
Calcium 7.7% Iron 9.5%
*Based on a 2000 Calorie diet


text:
Handmade at Kew
Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3AB
This four-day international contemporary craft event offers visitors the opportunity to meet and buy from over 200 extraordinary designer-makers working across all disciplines including: ceramics, jewellery, fashion and textiles, glass, paper, furniture, metalwork, sculpture and interior accessories.
Celebration of Craftsmanship and Design
Thirlestaine Long Gallery, Bath Road, Cheltenham, GL53 7LD
Celebration of Craftsmanship & Design has become the largest selling exhibition of high quality bespoke furniture in the country and every year it draws visitors and exhibitors from around the world.
Last Summer MissFire switched her Forest of Dean studio for the leafy canopy of West London's Kew Gardens for a few days, the perfect setting for her recent Flower Series.
Taking part in the Handmade at Kew event was one of the most exhilarating, exciting and exhausting experiences of her career so far.
Outside in the sunshine the Dicentra and Digitalis captured the attention of passers-by and beckoned them towards the entrance of the marquee, where 150 designer-makers exhibited their work. On stand K4 MissFire displayed a range of work, including brand new piece 'Red Cherries', and chatted to visitors over the course of four days.
The opportunity to meet so many new people was extremely rewarding, and being surrounded by a wealth of talent was invigorating and inspiring. Ceramicist Lindy Martin of 'All Washed Up', Jeweller Annika Rutlin, Daniel Bryne of 'Faunart' with his incredible butterflies, and Elliot Walker's stunning glass sculpture, to name a few...
I am grateful to all those who made it to the event, and of course to the organisers behind it all. Huge thanks goes to Paul McHugh of Inner Demon for capturing the essence of the event on film for you all to enjoy...
Elegance and Form Summer Sculpture Show
Wyndcliffe Court, St Arvans, Chepstow, NP16 6EY
Wyndcliffe Court Gardens are Grade II listed and designed in the Arts and Crafts style. Situated along the Wye Valley between Chepstow and Tintern.
Artist in Residence
Nature in Art, Wallsworth Hall, Twigworth, Glos, GL2 9PA
Find MissFire in the artist's studio during this week. Exhibiting and working on her latest creations. A fantastic opportunity to meet the artist in an inspiring setting.
Walford Mill Crafts - Garden Exhibition
Stone Lane, Wimborne, Dorset, BH21 1NL
Craft and the garden have enjoyed a symbiotic relationship for centuries, providing a continual source of inspiration for both artists and makers.
Charingworth Court Sculpture Exhibition
Winds of Change Gallery, 8 High Street, Winchcombe, GL54 5HT
An intimate outdoor sculpture exhibition held in the grounds of Charingworth Court, co-inciding with the NGS open gardens and the Winchcombe Festival of Music and Arts.
Affordable Garden Art Exhibition
Showborough House, Twyning, GL20 6DN
Showborough House opens its garden every spring to host the Affordable Garden Art Competition and Exhibition. A wide variety of sculpture can be seen in the natural setting of the one and a half acre garden
Elegance and Form Spring Sculpture Show
Wyndcliffe Court, St Arvans, Chepstow, NP16 6EY
Wyndcliffe Court Gardens are Grade II listed and designed in the Arts and Crafts style. Situated along the Wye Valley between Chepstow and Tintern.
To keep up to date with MissFire please 'like' my Facebook page.
If you want to see more recent works, browse my Portfolio
Copyright 2013. MissFire - Artist in Metal. All Rights Reserved.
MissFire would like to thank Inner Demon Ltd and Jonathan Gurr Photography for video footage and stills used on this website


text:
Mangolee Inc
- August 27, 2013
( 300)
"D10 CoolPix" brings 10 funniest pictures to you every day from around the world. Our editors work around the clock to bring you the latest and most popular pictures from Facebook, twitter, Instagram, Flickr and Youtube. Entertain yourself with all these pictures. At least 10 pictures are added every day.
Excellent very nice application
روعه برنامج راقي
Real nice
Good Good idea
galaxy s2 its the best app يعتيك العافية


text:
Karahe Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Airport Transportation
- Beach
- Free High-Speed Internet
- Continental Breakfast
- Swimming pool
- Restaurant
Photos of Karahe Hotel
Travelers also recommend:
- Beach
- Swimming pool
- Restaurant
- Bar/lounge
- Free High-Speed Internet
- Wheelchair accessibility
- Free parking
- Beverage Selection
- Airport Transportation
- Continental Breakfast
TravelPod Member ReviewsKarahe Hotel Manuel Antonio National Park
If you like sleeping with a thousand ants in your room and taking a shower with a thousand more then you should definitely come here. Otherwise, I advise against it. Loved the beach here and loved the staff but woke up with a billion bug bites that I didn't have when I went to bed.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews Karahe Hotel Manuel Antonio National Park
Travel Blogs from Manuel Antonio National Park
Pura Vida here we come!
... He charges us $20 to go 3.5 miles to the airport. I know he is robbing us but I am more concerned about making my flight than arguing with a thief. When we arrive, the masses of crowds tell me that was the right choice. Lines, lines, lines...as far as I can see. Geez, this is crazy. We get our tickets and try to find the security checkpoint. The line is so long I can't find the end of it. We can't figure out if people are going into the same area or ...
Costa Rica - Manuel Antonio Day 2&3
... than is typical. thank goodness for us otherwise we would have died. (not literally mom....) they did recommend a rafting trip out of San Jose. They said it was 3 days and there are these amazing lodges on the river that you stay at. Sounded awesome! but in all honestly I don't know we would come back here. one it's kind of a pain in the bottom to get here to Manuel Antonio (a long flight to san jose then a 4 hour bus ride, although you could get a charter ...
A Monkey Wrench in the Works, Minus the Monkeys
... of course were having none of his bullsh*t, and told the company (no names but it rhymes with Smudge It) to get their asses up to the park and fix the car. Two sweaty hours in the baking sun later, it was agreed by all parties involved (us, Smudge It, and a mechanic) that the fob sensor had indeed broken, it wasn't our fault, and we were given a new car. So instead of the sunset happy hour we'd planned, we just headed back to the hotel for a shower and a nap. Upon arrival, ...
Animals Galore
... storm we've ever experienced. It was like the storm sat above our head for a couple of hours and dropped a years worth of rain in that time. The lightening covered the entire sky in flashes which lasted up to 2 seconds and the thunder felt, and sounded, like it was 10m above the house. The house was actually shaking with the biggest flashes that touched the ground. Really amazing experience even if a little worrying at times...
A Day on the Boat
... ride this afternoon that leaves from the Quepos Marina. The van ride there was sweltering but certainly worth it. We spent about 4 hours on the boat, went swimming, and had a delicious dinner. Then my wonderful friends Jerry and John got engaged on the front of the boat facing the sunset. It was very nice and I am truly happy for them both!!! It was a great day for everyone on the trip ...


text:
Amateur FFM Interracial Dreier in der Sauna
Four Ladies and one lucky guy!
Reaching new level
Teen helps her friend to get fucked
You only live once. Don't be a pussy!
Taking a break from touring
Sophia and I decided to pick up a random boy
Summer paradise with horny blondes
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Perfect sluts team up
Learning Curves
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Two busty brunette MILFs share a cock
Avril Hall and Kristal Summers crazy ffm in the living room
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Euro Teen Riding Rocco Siffredi with Ass
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Passionate threesome in the couch
Teen babe caught MILF sucking off her BF
With her step mother
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text:
Mobile QA Engineer
Engineering | Santa Monica, CA | Full Time
Mobile QA Engineer
Who are we? We are a well funded technology startup specializing in secure mobile messaging, located in Santa Monica, CA.
What is in it for you?
- Great salary
- Full benefits
- Fun, fast paced, laid back startup environment
What you will be doing:
- Creating, maintaining and executing test plans and test cases
- Participating in design and specification reviews
- Partnering with the development team to troubleshoot and resolve issues quickly for rapid release iteration
- Tracking industry's best practices for QA testing of mobile apps
Qualifications & Desired Skills
- BS in CS or similar field from a 4 year university required
- 2+ years testing commercial software on one or more mobile platforms
- Software development experience
- Coding knowledge in one or more of the following languages: C/C++, Perl, Python, Java, Objective-C
- Experience with iPhone/Android mobile technologies, Java, MySQL, and Cocoa
- Strong experience in both Blackbox and White-box testing
- Comfort with agile development
- Web Automation / Testing:
- Experience with Selenium, Watir or other testing frameworks
- Ruby, Python, Java development skills for automating testing using
the above frameworks
- Mobile Testing:
- iOS testing experience with KIF / Objective-C
- Android testing experience with AndroidTestCase, Robotium, Roboelectric, etc
- Performance / Load Testing:
- Experience with Tsung, Jmeter, Loadrunner or other load testing tools
- Experience instrumenting servers to capture critical metrics
coinciding with performance testing
- Continuous Integration:
- Experience setting up and configuring CI environment with Jenkins,
Hudson or other continuous integration server
- Ability to generate and run automated testing scripts after CI builds
TigerText, Inc is proud to be an Equal Opportunity Employer. Applicants are considered for all positions without regard to race, color, religion, sex, national origin, age, disability, sexual orientation, ancestry, marital or veteran status.


text:
Ginger Pear Marmalade
|Firm pears
|4 Pound, sliced to make 10 cups (10 Large Size)
|White sugar
|6 Cup (96 tbs)
|Fresh green ginger
|3 Ounce, peeled, sliced to make 1/2 cup
Place the sliced pears and sugar in a large preserving kettle.
Peel the zest off the lemons, and sliver finely.
Juice the lemons.
Add these ingredients and the ginger to the pears.
Stir well, cover and leave overnight.
The next day, uncover, bring to the boil, reduce heat and stirring frequently, simmer gently 40-45 minutes or until the marmalade is thick and the fruit transparent.
Pour into hot sterilized jars.
Seal with melted paraffin wax.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 5787 Calories from Fat 27
% Daily Value*
Total Fat 3 g4.9%
Saturated Fat 0.33 g1.6%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 32.7 mg1.4%
Total Carbohydrates 1508 g502.6%
Dietary Fiber 63.4 g253.6%
Sugars 1378.2 g
Protein 10 g19.7%
Vitamin A 9% Vitamin C 283%
Calcium 26% Iron 25.1%
*Based on a 2000 Calorie diet


text:
Wrong (2013)
Blend Film Database
Wrong Synopsis
Dolph Springer (Jack Plotnick of Comedy Central's
Reno 911!
) awakens one morning to find he has lost the sole love of his life - his dog, Paul. Desperate to reunite with his best friend and to set things right, Dolph embarks on a journey which spirals into the realm of the absurd. On his quest, he alters the lives of several bizarro characters, including a promiscuous pizza delivery girl (Alexis Dziena from HBO's
), a mentally unstable, jogging-addicted neighbor, an opportunistic French-Mexican gardener, an eccentric pet detective (Steve Little of HBO's
Eastbound And Down
) and most mysterious of all, an enigmatic pony-tailed guru, Master Chang (William Fichtner from HBO's
) who imparts his teachings to Dolph on how to metaphysically reconnect with his pet. From fearless cinematic surrealist Quentin Dupieux, the director behind the head-exploding Rubber,
is an entrancing and wholly original hallucinatory universe all its own, which TwitchFilm calls "a wild and hilarious ride of absurdity!"
Wrong Release Date
In Theaters March 29, 2013
Wrong Credits
Jack Plotnick, Todd Giebenhain, Eric Judor, Alexis Dziena, and William Fichtner
Written By:
Quentin Dupieux
Directed By:
Quentin Dupieux
Produced By:
Gregory Bernard, Nicolas Lhermitte, and Josef Lieck
Drafthouse Films
External Info:
Wrong Official Website
Running Time:
94 min.
Subscribe To Topics You're Interested In
Subscribe To Topics You're Interested In
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If you're excited for Wrong
Wrong Images
Latest Wrong News
Exclusive Motion Poster For Quentin Dupieux's Wrong Will Get You Ready For The Weird
What you see featured in the motion poster inside is a shot from the very beginning from Quentin Dupieux's Wrong. In the scene, a firefighter drops trou in the middle of the street and starts taking a number two while an unmarked white van burns to ashes in the background...
Eric Eisenberg
Mar 28, 2013
Exclusive Motion Poster For Quentin Dupieux's Wrong Will Get You Ready For The Weird
Quentin Dupieux's Wrong Gets An Insanely Weird New Trailer
Anyone who knows the work of director Quentin Dupieux's knows that the filmmaker doesn't quite have the same sensibilities as most. To put it bluntly, his movies are pretty goddamn weird. Take, for example, his 2010 film Rubber. Not only was the movie's main character a telekinetic used tire named Robert who enjoys blowing up peoples' heads, the film features its own audience that watches the plot unfold while they stand on a hill using binoculars.
Eric Eisenberg
Jan 09, 2013
Quentin Dupieux's Wrong Gets An Insanely Weird New Trailer
Alamo Drafthouse Reveals Mind-Bending Poster For Quentin Dupieux's Wrong
With the imaginative but downright weird horror-comedy Rubber, writer-director Quentin Dupieux established himself as a filmmaker to watch. I mean, how many moviemakers think to make their protagonist an actual tire named Robert, who has a passionate obsession for a beautiful young woman and a telekinetic power for destruction on par with Carrie White? Just Dupieux.
Kristy Puchko
Jan 09, 2013
Alamo Drafthouse Reveals Mind-Bending Poster For Quentin Dupieux's Wrong
Sundance Teaser Trailer For Wrong, From The Director Of Rubber
As was said in the Sundance rundown, the film is about a man named Dolph (Plotnick) who is searching for his lost dog, but constantly keeps running into strange characters, including "a nympho pizza-delivery girl, a jogging neighbor seeking the absolute, and a mysterious righter of wrongs." Sadly the film doesn't have a distributor yet (hopefully its show at January's festival will change that) and, therefore, does not yet have a release date.
Eric Eisenberg
Nov 30, 2011
Sundance Teaser Trailer For Wrong, From The Director Of Rubber
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text:
2063 Brea Mall, Brea Mall, Brea, California, 92821
Note: Brea Mall
(714) 674-5040
Fax: (714) 674-5044
Click Here for 40% Off Lenses with Frame Purchase
Personal Services & Care > Repair Services
With a mission of helping people look and see their best, your Brea LensCrafters has a passion for eyes. LensCrafters located at 2063 Brea Mall offers the best selection of the latest trends in eyewear from leading designer brands —and an on-site lens finishing laboratory for the fastest service & most personalized prescription. Associates at LensCrafters are trained to provide you with personalized eye health service throughout your experience. Eye exams are available from Independent Doctors of Optometry at or next to LensCrafters in most states.
to 9:00pm
Tuesday: 10:00am to 9:00pm
Wednesday: 10:00am to 9:00pm
Thursday: 10:00am to 9:00pm
Friday: 10:00am to 9:00pm
Saturday: 10:00am to 8:00pm
Sunday: 11:00am to 6:00pm
Payment options: American Express, Cash, Check, Discover, MasterCard, Visa
Twitter: @LensCrafters
Facebook: http://www.facebook.com/LensCrafters
Year established: 1983
Associations: OneSight Foundation
Specialties: Prescription Eyewear, Digital Retina Photo - varies by location
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Services: AccuFit, myLook


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Repeated exposure to environmental agents, such as pesticides and metals, can alter gene expression patterns, potentially resulting in enhanced susceptibility to future toxic insults. With greater than 90% of Parkinson's disease (PD) cases considered idiopathic, epidemiology has indicated the involvement of pesticides in PD. Specifically, exposures to the herbicide paraquat (PQ) and the fungicide maneb (MB) are associated with a 75-80% increased risk of PD. Additionally, epigenomic changes in gene expression are postulated to play a role in neurodegenerative disorders like PD. My previous NIEHS funded research (F32 ES019821) demonstrated that MB-potentiation of PQ neurotoxicity was not simply due to enhanced oxidative stress, but a complex mechanism involving thiol-modification by MB and oxidation by PQ. Additional gene expression data show that MB significantly altered the expression of more genes compared to PQ. MB induced 4 different amino acid transporters and 2 metal transporters. Of particular interest, Ala-, Ser-, Cys- preferring transporter-1 (ASCT-1 (Slc1a4)) and proton coupled, divalent metal ion transporter (LSH (Slc11a1)) were induced greater than 2-fold by MB and PQ+MB compared to control. The working hypothesis for this K99/R00 Career Development Award proposal is that long-term exposure to MB potentiates PQ-mediated neurodegeneration of dopaminergic neurons caused by increased uptake of PQ due to modified amino acid transporter expression, metal-mediated oxidative stress and changes in the epigenome. To accomplish this, 4 specific aims (2 mentored, 2 independent) consisting of in vitro and in vivo models will be used.
In Specific Aim 1 (K99 mentored phase), both in vitro and in vivo models will be employed to determine if potentiation of PQ neurotoxicity is due to MB-mediated induction of ASCT-1 and LSH.
Specific Aim 2 (K99 mentored phase) will study if methylation of genes associated with dopamine metabolism is mechanistically involved in MB- potentiated PQ neurotoxicity. Research proposed in Specific Aim 3 (R00 independent phase) will explore alterations in histone H3 methylation and acetylation caused by long term pesticide exposure. Lastly, Specific Aim 4 (R00 independent phase) will investigate global alterations in the DNA methylome in response to long term pesticide exposure. This project is designed to further develop my research program and fulfill strategic goals of the NIEHS by connecting environmental influences to disease through the study of epigenomics and to train the next generation of environmental scientists. The proposed research will meet these goals and foster the development of my independent research career.
Pesticide exposure is believed to contribute to the development of Parkinson's disease, which affects 1% of the worldwide population. We believe that effects occur due to a combination of pesticides, where one pesticide can enhance the toxicity of a second pesticide via increased transport and altered gene expression. This project is designed to test this hypothesis.


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Melanocortin-3 receptors (MC3R) are an important component of the central nervous melanocortin system. While this system is under active investigation with respect to energy homeostasis and obesity, surprisingly little is known about the specific functions of MC3Rs expressed in the brain. Our long term goal has been to investigate and understand the functions of MC3R in the central nervous system. In the previous funding cycle, we developed the overarching research hypothesis that MC3R(+ve) neurons are a point of convergence for systems governing the anticipatory response to nutrient intake. The overall objective of the next funding cycle is to identify and characterize MC3R(+ve) neurons involved in expression of the anticipatory response to food intake. To achieve this objective, we developed a strain of C57BL/6J mice where Mc3r transcription is inhibited by a "lox-stop-lox" (LoxTB) sequence inserted 5'of the open reading frame. We will use this model in pursuing the following specific aims to test the central hypothesis.
Aim 1 will identify MC3R signaling pathways involved in regulating the expression of ingestive behaviors anticipating nutrient intake. The anticipatory response appears to involve a circadian or clock-like mechanism. Our data suggests that MC3Rs are inputs into systems governing the synchronization of circadian rhythms with food intake.
This aim will investigate the working hypothesis that the expression of rhythms anticipating food presentation involves actions of MC3Rs in the dorsomedial and lateral hypothalamus and in mesolimbic dopaminergic neurons. These objectives will be met by assessing FAA and entrainment of circadian rhythms to food in LoxTB MC3R mice crossed with transgenic mouse strains expressing Cre in areas of the mediobasal hypothalamus and ventral tegmental area.
Aim 2 will identify MC3R signaling pathways responsible for maintaining metabolic homeostasis and synchronizing metabolic rhythms during restricted feeding. It is well established that the central nervous Melanocortin system is coupled to efferent pathways governing glucose and fatty acid metabolism. Our data suggests that MC3Rs regulate inputs into systems that govern hepatic glucose production and insulin action during periodic cycles of fasting and re-feeding.
This aim will investigate the working hypothesis that actions of MC3Rs expressed in the lateral and ventromedial hypothalami are involved in synchronizing rhythms in metabolism with food availability to minimize the impact of nutrients on the body. Melanocortin analogs are being actively investigated in the development of therapies against obesity and diabetes, so the outcomes from the proposed research may have a positive impact on the development of new therapies. Outcomes from the proposed research also have the potential to impact on strategies for treating metabolic disorders through using MC3R modulators. Moreover, investigating the regulation of circadian rhythms by MC3Rs could also have an impact on the development of treatments for behavioral disorders linked to aberrant circadian function.
of the proposed research to public health is based on clinical data showing that the Melanocortin system functions to prevent obesity in humans. This system is considered an attractive target for developing drugs against obesity and eating disorders, however little is known about the functions of melanocortin-3 receptors. The proposed research may therefore have a direct impact on the development of drugs targeting this system.
|Lute, Beth; Jou, William; Lateef, Dalya M et al. (2014) Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab 20:333-45
|Girardet, Clemence; Butler, Andrew A (2014) Neural melanocortin receptors in obesity and related metabolic disorders. Biochim Biophys Acta 1842:482-94
|Butler, Andrew A; O'Rourke, Robert W (2013) Bariatric surgery in the era of personalized medicine. Gastroenterology 144:497-500
|Begriche, Karima; Girardet, Clemence; McDonald, Patricia et al. (2013) Melanocortin-3 receptors and metabolic homeostasis. Prog Mol Biol Transl Sci 114:109-46
|Begriche, K; Marston, O J; Rossi, J et al. (2012) Melanocortin-3 receptors are involved in adaptation to restricted feeding. Genes Brain Behav 11:291-302
|Begriche, Karima; Sutton, Gregory M; Butler, Andrew A (2011) Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism. Physiol Behav 104:546-54
|Smith, B J; Sutton, G M; Wu, X et al. (2011) Ovariectomy and genes encoding core circadian regulatory proteins in murine bone. Osteoporos Int 22:1633-9
|Begriche, Karima; Levasseur, Peter R; Zhang, Jingying et al. (2011) Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis. J Biol Chem 286:40771-81
|Sutton, Gregory M; Begriche, Karima; Kumar, K Ganesh et al. (2010) Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J 24:862-72
|Sutton, Gregory M; Centanni, Armand V; Butler, Andrew A (2010) Protein malnutrition during pregnancy in C57BL/6J mice results in offspring with altered circadian physiology before obesity. Endocrinology 151:1570-80
Showing the most recent 10 out of 15 publications


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chicagoyogi Review
Not your boring vanity mirror
I wanted an oval mirror but not the typical boring one everyone has. This was is an interesting shape and matches my new TOTO sink just right!! And you can't beat the price!
- How did the color on site compare with the actual product? Exact match
- Please tell us about the quality of the product. Seems good
- How accurate was the on site description of the product? Good
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Puyang Zonghoo Industry&Trading Co., Ltd.
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The supplier's company premises has been checked by Alibaba.com staff to ensure onsite operations exist there. A third-party verification company has confirmed the legal status of the supplier.
|Business Type:
|Manufacturer, Trading Company
|Henan, China (Mainland)
|Main Products:
|Flaxseed Oil,Grape Seed Oil,Walnut Oil,Rice Bran Oil,Safflower Seed Oil,Camellia Oil
|Total Employees:
|51 - 100 People
|Total Annual Revenue:
|US$1 Million - US$2.5 Million
|Year Established:
|Top 3 Markets:
|Domestic Market 30.00% North America 18.00% Oceania 14.00%
|Product Certifications:
|Business license of enterprise legal person
Puyang Zonghoo Industry&Trading Co., Ltd is a modernize enterprise which mainly concerned with N...
Puyang Zonghoo Industry&Trading Co., Ltd is a modernize enterprise which mainly concerned with Natural plant resources' scientific research, production and trade. Our company is located at Puyang city, Henan province. Close to Beijing-Guangzhou and Beijing-Kowloon Railway line. Transport is exceptionally convenient and geographic position is advantage.
Since the establishment we hold the "Extract the Plant's Essence for Your Healthy Life" as our company management concept. Our main products contain two series: previous oil series & plant extract for about hundreds of plant extracts. We own the Import & Export right and have exported the products to Europe, North America, Japan, Korea, Middle East and Southeast Asia etc.
In order to have the continuous improvement in plant extracts' new applications and new production technologies; we keep close and long term cooperation with prestigious universities and research institutions. We own perfect production equipments and raw material supply base for providing you with high quality assured products
Our company - holding the true faith and innovation as business philosophy; the customer first as working principle to provide you with excellent products and favorable services, we sincerely wish to cooperate with you!
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Trade & Market
|Main Markets
|Total Revenue(%)
|Domestic Market
|North America
|Western Europe
|Eastern Asia
|Mid East
|Southern Europe
|Eastern Europe
|South Asia
|Southeast Asia
|Northern Europe
|Export Percentage:
|81% - 90%
|Export Mode:
|Have Own Export License
|No. of Employees in Trade Department:
|11-20 People
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Wealth Manager - the site for professional investment managers
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Gravis Capital Partners LLP is the Investment Manager and it will receive a management fee accrued daily and payable quarterly in arrears calculated at an annual rate of 1% of the prevailing NAV. No performance fee is earned by the Investment Manager. The Investment Management Agreement is for an initial term of 6 years, thereafter being terminable upon 12 months' written notice and at any time in the event of the insolvency of the Company or the Investment Manager.


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This review was written by a gamer who bought nostalrius gold several times from MmoGah, and the review was adapted by MmoGah. Let me share with you, and I hope that you can choose the best place to buy nostalrius gold!
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Re: What to bring as gifts for relatives
Well , I agree , most things can be found in Romania but maybe at a higher price than in the US...(as in brands)
Kids love technology and sweets and also the older people in general love sweets:) especially if they are gifts.
A T-shirt or a watch would be nice too for the kids and a scarf-shawl for the older lady...
Any gift would be appreciated!
Oh, and yes many Romanians that live in the US now, whenever they return to visit, they give money and not presents...sometimes that is helpful as there are people who need it, but money is not a gift that lasts...
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Holiday Inn & Suites at Grand Prairie
The Holiday Inn & Suites is Peoria's newest full service hotel! Conveniently located across from the Shoppes at Grand Prairie, this contemporary hotel offers everything you need when you're away from home. The modern rooms and suites feature high-speed internet, flat screen TV's, refrigerators, microwaves, Keurig coffee makers and comfortable beds for the ultimate sleep experience. Other hotel amenities include a relaxing indoor saline pool, on-site upscale casual restaurant and lounge, fully equipped fitness center, 24-hour E-Bar business center, flexible event space and complimentary parking. The staff at the Holiday Inn & Suites are proud to offer superior customer service and conveniences to make your stay easy and enjoyable.
Conveniently located at Monmouth Place at the intersection of IL Route 34, 67 and 164, each of our clean and spacious rooms feature plush bedding, high-speed internet, flat-screen TV's with cable channels, coffee makers and more. Of all the amenities you'll enjoy at AmericInn, quiet rooms may be your favorite. Every one of our rooms were built with AmercInn SoundGuard construction, assuring you a peaceful stay. Guests are also treated to other hotel amenities including a complimentary breakfast buffet, relaxing indoor pool and spa, fully equipped fitness center, private event space, an elegant and spacious lobby with a fireplace and cozy conversation areas. Welcome to the end of the day.
Attractive, two story updated home with a fenced backyard. Minutes from Lake Shelbyville and just blocks to downtown. House has 3 bedrooms, 2 baths, and a queen sleeper sofa for up to 8 guests. Fully equipped kitchen, washer and dryer, towels & linens provided. Streaming TV, Wi-Fi, A/C. Deck with seating, charcoal grill, Two night minimum Open Year round. Please call for pet policy.
122 guest rooms, Amenities: Business Center, Exercise Room, Outdooe Pool, Complimentary Hot Breakfast. Pet friendly - charges apply.
CITY:St. Charles
Crane Hollow Bed and Breakfast
Come hug an aged oak tree, watch the cranes in their early morning graze or search out the scarlet cardinal flowers. Listen to nature's whisper.
Best Western PLUS Chicagoland - Countryside
The Best Western hotel offers the best in amenities, customer service, and accommodations at an affordable rate. Located about 20 miles from Chicago and located on Old Route 66. Convenient access to I-55 brings them to the favorite Chicago area attractions. Hot breakfast buffet is complimentary along with High-Speed WiFi.
Holiday Inn William Tell Hotel Chicago SW Countryside Banquets and Conference Center
Located just minutes from downtown Chicago and both Midway and O'Hare airports, the Holiday Inn & William Tell Chicago SW Countryside Banquets and Conference Center is the premier destination for business and leisure travel. We feature 176 comfortable Countryside, IL hotel rooms appointed with modern amenities, over 25,000 square feet of flexible meeting space, onsite dining and easy access to area businesses and sightseeing. While here, guests can enjoy a 25-yard lap pool, sauna, steam room and jacuzzi tub, making us a top choice for families. Our Countryside, Illinois hotel is also pleased to offer complimentary Wi-Fi and a free shuttle within a 5-mile radius upon request. When it's time to explore, venture out to a plethora of nearby attractions and activities, including the Brookfield Zoo, Max McCook, Toyota Park and much more.
Conveniently located near I-55 and I-80, Wingate by Wyndham welcomes business, groups, sports and leisure travelers. Serving hot complimentary breakfast daily, business center, free parking, Wi-Fi, indoor pool and fitness center.
Get away from it all and enjoy the peaceful sounds of nature under the shade of the catalpa trees in this two bedroom cabin in scenic Calhoun County. The Watkins Place is private and secluded with access to the hiking trails at the McCully Heritage Project. Amenities include a full kitchen, coffee maker, refrigerator, all kitchen utensils, towels and linens and board games. There is no TV reception, internet or phone service.
A truly unique lodging experience is available at Sleepy Creek Vineyards! The lodging facility includes a full kitchen, living space, two private bedrooms, and a sleeping loft with maximum sleeping capacity of 10. The spacious retreat is close to Kickapoo State Park, Kennekuk County Park, and of course just steps away from the scenic 10 acre vineyards at Sleepy Creek.
Step back in time to simpler days at White Tales Lodge. Nestled in the beautiful and remote hills of Calhoun County, the lodge has a warm and inviting atmosphere and is surrounded by some of the most unforgettable landscapes in the Midwest. Enjoy hunting packages in season or design your own weekend getaway with the family. Outdoor cooking facilities are available as well as an indoor kitchen, dining room, game room and sleeping accommodations.
Homewood Suites by Hilton Schaumburg
Schaumburg's premier all-suite hotel offers a Suite Alternative for the traveler who expects all the comforts of home at a great price-value. Ideal for corporate travel, relocation and a leisure getaway with your family or friends.
Hilton Garden Inn Naperville/Warrenville
Close proximity to local businesses and attractions makes the Hilton Garden Inn an ideal spot for both business and leisure travelers. Rooms have a spacious desk, ergonomic chair, free high-speed internet, flat screen HD TV, microwave and refrigerator.
Holiday Inn Chicago Elk Grove Village
Conveniently located in the center of Elk Grove Village Business Complex and only 15 minutes from O'Hare International Airport (ORD). Hotel offers comfort, convenience and professionalism that your travelers deserve. Well-appointed, upgraded rooms, bright bathrooms with amenities from Bath & Body Works. Perfect environment to relax after a hard day at work. Complimentary wireless internet, local calls and business center. In the morning we suggest our cooked-to-order breakfast, fitness center and/or indoor pool, and sauna at no additional cost.
CITY:Elk Grove Village
Holiday Inn Express Hotel & Suites Deerfield-Lincolnshire
This beautiful hotel is conveniently located close to Six Flags Great America Amusement Park, Botanic Gardens, Gurnee Mills Outlet Mall, Great Lakes Naval Base, Ravinia and just 15 minutes from O'Hare International Airport. Our new contemporary rooms and whirlpool suites are a refreshing retreat and include a complimentary hot breakfast, microwave, mini refrigerator and wireless and wired high-speed Internet. The hotel offers an indoor pool, whirlpool and modern fitness center featuring Life Fitness Cardio equipment. Hotel also offers complimentary local shuttle.(Based upon availability) Business travelers can relax in one of the Executive suites, hold a meeting in the 900 sq. ft. meeting room and take advantage of the 24-hour business center.
Holiday Inn Express Hotel & Suites - Sycamore
69 rooms, all queen and king beds for your comfort. Located close to Northern Illinois University, Texas Roadhouse, and Walmart. Amenities include: Fitness Center, Indoor Pool, Free Continental Breakfast, Handicapped Accessible, Wi-Fi Access, Business Center, Refrigerators & Microwaves in all rooms.
Sheraton Chicago Northbrook Hotel
The Sheraton Chicago Northbrook's 161 deluxe guests rooms offer ultra-comfortable Sheraton Sweet Sleeper Bed and an oversized bath. The hotel's full service restaurant, Connections, serves breakfast, lunch, and dinner. Located in the upscale residential community of Northbrook, the hotel is within walking distance of many restaurants and shops.
Located just off of the South East corner of Pittsfield's town square, Monroe Street Suites is a luxury oasis, offering travelers quiet and unique accommodations with 6 themed African rooms to visit. Explore the decorated themes of Lions, Big Cats and Zebras, while in the heart of America's deer hunting capital, Pike County, Illinois.
A natural place to be... Welcome to the Hampton Inn McHenry. When the glaciers receded from this part of Illinois, they left behind a remarkable series of lakes, marshes and wetlands. These gorgeous natural areas have been preserved near the Hampton Inn® hotel in McHenry. Just minutes from the front door of our hotel in McHenry, you can see wildlife ranging from more than 100 species of bird to red fox and white-tail deer. For preservation of a different sort, simply walk through our downtown Riverwalk area to appreciate McHenry's commitment to its long history. And lastly, when you feel like a game of golf or a shopping excursion, you can find both near our hotel in McHenry. So come, check into the Hampton Inn hotel in McHenry. We think you'll find it a natural place to be.
243 rooms. 7 suits. One restaurant. Lounge. valet. business center. Exercise Facilities. Indoor pool. Room service. Amenities include complimentary shuttle to and from O'hare airport. Free pass to Bally Total Fitness. Located near O'Hare airport, 15 minutes from Downtown Chicago, Allstate Arena, Rosemont Theatre.
Southland Inn & Suites - Markham
Treat yourself to one of our deluxe whirlpool suites. Then start your morning off right with our deluxe complimentary breakfast bar. Smoking rooms are available upon request.
200 Rooms. Three suites. Seven meeting rooms. All non-smoking rooms. One restaurant. Indoor pool. On-site health club. Room service. Amenities include complimentary 24 hour shuttle service to Midway Airport, complimentary hi-speed internet service. Located near Orange Line trains to Downtown Chicago attractions.
Marriott Suites Chicago Deerfield
his hotel features 248 suites with a private parlor room separated by French doors. Suites include a spacious bedroom with a separate living area with sleeper sofa, wet bar, microwave, refrigerator, coffee maker, Plug-In Panel to connect your laptop, iPod
Hilton Chicago O'Hare Airport offers unparalleled convenience to savvy travelers in a quiet, no fly-zone. We are within walking distance to all domestic terminals via underground walkways and the Blue-line train to downtown Chicago. After your flight, swim some laps in the indoor swimming pool. Dine on the finest steaks, seafood and drinks, catch the game at our friendly sports bar or grab something quick at Caffé Mercato.


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Featuring a glossed obsidian upper and shiny bronze accents, this latest Jordan V retro follows the gold medal releases of weeks prior in true bronze medal form.
Available September 24th online and in store at Highs and Lows, King Street.
Reebok Fury Adapt - Black →
← Highs and Lows, Spring 16" Lookbook


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Styrene Butadiene Latex Market analysis is provided for global market including development trends by regions, competitive analysis of styrene butadiene latex market. Styrene-butadiene latex (SBL) is a water-based polymer produced by emulsion polymerisation from styrene and butadiene. SB latex is a water-based emulsion of styrene-butadiene copolymer particles. Featuring high elasticity and adhesive strength, SB latex is widely used in paper coating, carpet backing, wood lamination, and many other applications.
Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Styrene Butadiene Latex Market Research Report @ http://www.360marketupdates.com/global-styrene-butadiene-latex-market-by-manufacturers-regions-type-and-application-forecast-to-2021-10331285
Market Segment by Manufacturers, this report covers
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This report focuses on the Styrene Butadiene Latex in Global market, especially in North America, Styrene Butadiene Latex Market in Europe and Asia-Pacific, Styrene Butadiene Latex Market in Latin America, Styrene Butadiene Latex Market in Middle and Africa. This report categorizes the market based on manufacturers, regions, type and application.
Market Segment by Regions, regional analysis covers
Get Sample PDF of Styrene Butadiene Latex Market Report @ http://www.360marketupdates.com/enquiry/request-sample/10331285
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Market Segment by Applications, can be divided into
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Picked up the TF700 today
I just picked up the Infinity from BestBuy for $429.99, got them to price match a third party Amazon seller on a color they don't even stock (personal victory!) after trying with much futility to find a Nexus 10 in stock...well...anywhere.
So far I love it, upgraded from the TF101 because I was looking for something a bit snappier, happy with the results. I was trying to either pick up the N10 or wait for CES, but the deal I nabbed plus my getting a free iPad in the mail that I'm going to sell basically makes this a free upgrade plus $100 in my pocket. Any major differences I should note? I've seen threads about the 300 to 700 differences, but not much on the jump from the 101.
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Re: Picked up the TF700 today
I had the Nexus 7 until I sat on it and broke the same screen. I liked it. Went to Best Buy and ended up buying the Infinity TF700. I absolutely love it.
Sent from my ASUS Transformer Pad TF700T using Tapatalk 2
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Re: Picked up the TF700 today
Noggaholic, do you have flash player installed on your Infinity? If you don't and you want it, check my posts under the threads "Considering purchasing the Infinity 700" or "WeChat Incompatability" on how to successfully download flash player to your Infinity.
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text: Rally Drivers Have Monster Crash And Even More Hilarious ResponseMichael Ballaban8/23/14 4:19pmFiled to: LOLCarsRacingWRCRallyCar Crashes799EditPromoteShare to KinjaToggle Conversation toolsGo to permalinkDriver Thierry Neuville is rapidly gaining a reputation around these parts, both for incredible drifts and humongous crashes. But when he and co-pilot Nicolas Gilsoul went off the course at the Rally Deutschland this week, their passionate cries of " AHHH FUCK FUCK FUCK FUCK FUCK" rang throughout the land. If you found yourself sliding off the road and doing a sextuple barrel roll into a German vineyard, you might find yourself spouting a string of profanity as you tumble down the hill, too. But somehow it's even funnier when they're professional rally drivers. Advertisement Advertisement And they're Belgian.*Both were unhurt, but that's just really a huge testament to the safety technology in their Hyundai rallycar. Seriously, just watch it from the outside:Reply79 repliesLeave a reply


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Breeder Directory
The UK Dog Breeder Directory is a comprehensive, searchable guide used by thousands of prospective dog owners who are actively searching for high quality, ethical dog breeders as well as information and advice on particular pedigree dog breeds.
The UK Dog Breeder Directory applies the highest standards of practice complete with our own 'Charter for ethical dog breeding'.
Our motto:
"The UK Dog Breeder Directory breeder has three priorities – 1) Health, 2) Health, 3) Health"
If you are looking for a puppy and want one today, you're in the wrong place. We promote research and encourage dialogue between breeder and buyer.
If you are looking for the cheapest prices for puppies, you're in the wrong place. Our breeders emphasise quality, quality and quality. A dog will be with you for upwards of a decade – it is NOT the same as buying a new fridge.
If you are looking for high quality pedigree dog breeders who will engage and educate you about the breeds in which they specialise, welcome to The UK Dog Breeder Directory!
UK Breeder Directory published by Indy Media.
Select Your Favourite Dog Breed or Choose a Breeder…
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PANDORA CHARM Related Articles
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Give older ornaments a renewed look by sprucing them up utilizing the identical provides with the intention to mix in together with your new ornaments. Each year make and add new kinds of ornaments to your assortment. Make extra ornaments to provide as gifts to associates, teachers and relations.
Obviously, on this state silver is useless for jewellery purposes. To keep away from the problems of malleability and softening, and thus to extend the life-span of your silver jewelry, other metals are added to the pure silver. The result of this mixing process with alloys is a mixed silver and alloy substance which is way extra resistant to scratching and harm.


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Moscow, Russia
Turned Pro:2007
2016 Earnings:$328,339
Two-time champion Ferrer and Sousa, who reached the final two years ago, are the top two seeded players this year.
Jul 11, 2016
by AP
The world No. 118 only faced one break point against the 39th-ranked Croatian.
Oct 20, 2015
Jan 05, 2015
U.S. Open champion earns 6-3, 3-6, 6-3 victory; Begu tops second-seeded Makarova 6-4, 6-4.
Oct 15, 2014
Does Francis Tiafoe have the right game? Where were the women in D.C.? Plus: Tuesday preview.
Jul 29, 2014
by Steve Tignor


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02.08.2017 Mars Reconnaissance Orbiter Observes Changes
01.26.2017 Mono Lake
01.25.2017 'Wing' Dike of Hardened Lava in New Mexico
01.25.2017 Blade-Like Martian Walls Outline Polygons
01.23.2017 Spirit And Opportunity By The Numbers
01.10.2017 Mars 2020 Rover - Artist's Concept
01.06.2017 Earth and Its Moon, as Seen From Mars
12.13.2016 Now and Long Ago at Gale Crater, Mars
12.13.2016 Where's Boron? Mars Rover Detects It
11.15.2016 Schiaparelli Impact Site on Mars, Stereo
11.03.2016 Schiaparelli Impact Site on Mars, in Color
10.17.2016 MAVEN Captures Rapid Cloud Formation
10.17.2016 Mars' Nightside Atmosphere
10.17.2016 Ultraviolet Image Near Mars' South Pole
10.17.2016 Ultraviolet Mars Reveals Cloud Formation
10.05.2016 Dust Haze Hiding the Martian Surface in 2001
10.04.2016 Test of Lander Vision System for Mars 2020
10.03.2016 A Sharpened Ultraviolet View of Mars
10.03.2016 Curiosity Self-Portrait at 'Murray Buttes'
10.03.2016 Butte 'M9a' in 'Murray Buttes' on Mars
09.19.2016 Ribbon Cutting
09.09.2016 Farewell to Murray Buttes (Image 5)
09.09.2016 Farewell to Murray Buttes (Image 4)
09.09.2016 Farewell to Murray Buttes (Image 3)
09.09.2016 Farewell to Murray Buttes (Image 2)
09.09.2016 Farewell to Murray Buttes (Image 1)
08.26.2016 Out-of-this-World Records
08.04.2016 Mars Rover Is New Social Media Game
08.04.2016 Mars Rover Social Media Game
08.02.2016 Artist Concept for RIMFAX
07.20.2016 Viking 40 Year Anniversary Artwork: Medal
07.18.2016 Mars 2020 Range Trigger
07.14.2016 NASA to Launch Mars Rover in 2020
'Cumberland' Selected as Curiosity's Second Drilling TargetThis map shows the location of "Cumberland," the second rock-drilling target for NASA's Mars rover Curiosity, in relation to the rover's first drilling target, "John Klein," within the southwestern lobe of a shallow depression called "Yellowknife Bay." Cumberland, like John Klein, is a patch of flat-lying bedrock with pale veins and bumpy surface texture. The bumpiness is due to erosion-resistant nodules within the rock, which have been identified as concretions resulting from the action of mineral-laden water.
North is to the top of the map. The scale bar is 50 meters (164 feet). Cumberland lies about nine feet (2.75 meters) west of John Klein. The base map is part of an image from the High Resolution Imaging Science Experiment (HiRISE) camera on NASA's Mars Reconnaissance Orbiter. The mapped area is within Gale Crater and north of the mountain called Mount Sharp in the middle of the crater. After completion of investigations near the edge of Yellowknife Bay, the rover's main science destination will be on the lower reaches of Mount Sharp. For broader-context views of the area, see PIA16832, PIA16064 and PIA16058.
Image Credit: NASA/JPL-Caltech/Univ. of Arizona
All Images