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Sjogren's syndrome (SS) is a common, complex autoimmune disorder characterized by lymphocytic infiltration into exocrine glands causing dry mouth and eyes, fatigue, malaise, and polyarthritis. Diagnosis of SS remains challenging and limited therapeutic options often culminate in irreversible destruction of the exocrine glands. SS shares many clinical and immunological similarities with other autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, Though large-scale genetic and genomic studies performed in these other diseases have proven enormously successful in identifying novel target pathways and loci associated with disease, the genetics of SS are woefully unexplored, giving us an opportunity to make an important contribution toward conquering this enigmatic disease. With the guidance, assistance and resources provided by the Oklahoma Sjogren's Syndrome Centers for Research Translation (OSSCORT), we will use state-of-the-art genetic and analytical tools to integrate extensive laboratory, clinical and genetic data to identify and characterize the molecular basis of etiology and pathogenesis of human SS. Specifically, we propose to 1) test for association of SS with genetic variants previously shown to be association with SLE and other autoimmune diseases using the ImmunoChip;2) perform genome-wide association studies to identify novel candidate loci associated with SS susceptibility and disease subphenotypes through integrative analyses of genetic, genomic, laboratory and clinical data, and 3) establish novel robust genetic associations with SS through replication in independent cohorts. We will exploit our substantial infrastructure and network of multidisciplinary experts to achieve these goals. No other group in the world has the sample sizes, volume of clinical data, or concentration of expertise to conduct these studies. At the completion of Project 1, we will provide new genes with fundamental insights into the mechanisms regarding etiology of SS. At the same time, the infrastructure developed through this OSSCORT will provide the basis for and have profound effects on future investigations in SS and potentially related autoimmune disease.
We are witnesses to the genetic revolution coming to fruition for the basic understanding of human disease and hope to include in this march of progress. SS is clearly a disabling disorder affecting a significant proportion of the US population. The identification of genes associated with SS has significant potential for rapidly advancing our understanding of disease mechanism and ultimately, in its etiology and pathogenesis.
|Seror, Raphaèle; Theander, Elke; Brun, Johan G et al. (2015) Validation of EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI). Ann Rheum Dis 74:859-66
|Altorok, Nezam; Coit, Patrick; Hughes, Travis et al. (2014) Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome. Arthritis Rheumatol 66:731-9
|Rasmussen, Astrid; Ice, John A; Li, He et al. (2014) Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. Ann Rheum Dis 73:31-8
|Maier-Moore, Jacen S; Horton, Christopher G; Mathews, Shirley A et al. (2014) Interleukin-6 deficiency corrects nephritis, lymphocyte abnormalities, and secondary Sjögren's syndrome features in lupus-prone Sle1.Yaa mice. Arthritis Rheumatol 66:2521-31
|Maier-Moore, Jacen S; Koelsch, Kristi A; Smith, Kenneth et al. (2014) Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjögren's syndrome. Arthritis Rheumatol 66:3445-56
|Igoe, Ann; Scofield, R Hal (2013) Autoimmunity and infection in Sjogren's syndrome. Curr Opin Rheumatol 25:480-7
|Lessard, Christopher J; Li, He; Adrianto, Indra et al. (2013) Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet 45:1284-92


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Below is an excerpt of an inspiring article in the Winter Issue of On Patrol, the Magazine of the USO. Click here to read the full story and hear and audio interview with the artist. Click here to learn how to get your own subscription.
[caption id="attachment_619" align="alignright" width="300" caption="Michael Naranjo with the Eagle Dancer. Photo by David Holman."][/caption]
"By David Holman - Santa Fe, New Mexico
Michael Naranjo reaches up and runs his fingers over the bronze nose and lips of a sculpture that he passes every day. "It has been a while since I looked at his face." The eagle dancer, a figure common in Pueblo Indian ceremonies, is mid-trot with his arms effortlessly waving attached feathers. With his one functional hand, Michael sculpted the exquisitely detailed eagle dancer that sits in front of his Santa Fe home — one "look" at a time.
Michael is blind from wounds he received in the Vietnam War. And he wouldn't sculpt any other way." …read more.
More from the USO
Feb 9, 2017
Baking a Difference: Dog Tag Bakery Provides Job Training and Community for Transitioning Service Members
Upon first glance, Dog Tag Bakery seems like any other cafe. But one look at the patriotic décor – like the dog tag chandelier – and it's clear there's more going on behind the counter than cake decorating.

subset: commoncrawl


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1kg packet frozen octopus tentacles
1 cup red wine
2 fresh bay leaves
2 tsp salt
2 tsp black peppercorns
1 small bulb fennel
1 eschallot
¼ cup flat leaf parsley leaves
¼ red capsicum
1 Tbsp dry wild oregano leaves
4 Tbsp extra virgin olive oil
2 Tbsp red wine vinegar
1 loaf crusty bread, sliced thickly
1 clove garlic
Thaw and rinse octopus. Place in a medium sized pot with wine, bay leaves, salt, pepper and ½ fennel bulb (reserving fronds). Add just enough cold water to cover, then apply a cartouche (a piece of baking paper over the top, touching the contents, to prevent drying out). Bring to a slow simmer, then cook for approximately 30 minutes until tender. Allow to cool in the stock.
Once octopus is cool, remove from the stock and pat dry with paper towel. Slice into 0.5 cm thick disks. Very finely chop remaining fennel (white part only), eschallot, parsley, and red capsicum. Mix together with olive oil, vinegar and wild oregano until well coated and check for seasoning.
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The Dynamics of Statistical Discrimination
This article demonstrates how learning dynamics select among equilibria in a statistical discrimination model of employment. The static market model exhibits multiple equilibria. The belief revision dynamics generate a Markov market process which, in the long run, is mostly near one and only one of the static equilibria, regardless of initial conditions. Usually policy effects appear in comparative statics, where the equilibrium set moves with different policies. But here policy is also seen to effect which equilibrium is selected even when it has no comparative statics effect at all. Copyright 2006 The Author(s). Journal compilation Royal Economic Society 2006.
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Volume (Year): 116 (2006)
Issue (Month): 515 (November)
Pages: 480-498
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Soldier Killed By Rocket Propelled Grenade In Afghanistan
Wednesday, July 17, 2013
Army Staff Sgt. Sonny C. Zimmerman, 25, was killed July 16 in Mushaka, Afghanistan when a rocket propelled grenade hit his vehicle, according to the Department of Defense.
Zimmerman was assigned to the 1st Battalion, 506th Infantry Regiment, 4th Brigade Combat Team at Fort Campbell in Kentucky.
Zimmerman was from Waynesfield, Ohio. According to WTVF-TV, he is survived by his wife, Morgan; his stepdaughter, Riley McVicker; and his parents, Chris Zimmerman and Michelle Fischbach.
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Early Buddhism: A New Approach
The I of the Beholder
By (author) Sue Hamilton-Blyth
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Early Buddhism: A New Approach by Sue Hamilton-Blyth
Book DescriptionNew interpretations of the central teachings of early Buddhism, mainly the relationship between identity and perception in early Buddhism.
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Book DetailsISBN: 9780700712809
(234mm x 156mm x 24mm)
Pages: 248
Imprint: RoutledgeCurzon
Publisher: Taylor & Francis Ltd
Publish Date: 16-May-2000
Country of Publication: United Kingdom
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This work focuses on the relationship between identity and perception in early Buddhism, drawing out and explaining the way they relate in terms of experience. It presents a picture of these issues in the context of Buddhist teachings as a whole and suggests they represent what Buddha taught.
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text: Witness The Insanity Of Galaga Legions DX, The Next Game From The Pac-Man CE TeamMichael McWhertor4/06/11 3:40pmFiled to: VideoGalaga legions dxGalaga LegionsXbox Live ArcadeXblapsnplaystation networkPS3Xbox 360Namco BandaiNamcoGalaga73EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Galaga goes completely batshit insane with the next re-imagining of Namco's shoot 'em up series, Galaga Legions DX. This is the next effort from the people who make the excellent Pac-Man Championship Edition games, so we'd better pay attention. Advertisement As you can see in the first real footage of this PlayStation Network and Xbox Live Arcade game, Galaga Legions DX aims to fill our screens with thousands of Galaga armada ships, turning this series into more of a space-bug hell shooter than before. One newly touted feature is "Focus Fire," which appears to offer better control of secondary aiming.Galaga Legions DX is coming to the PlayStation 3 and Xbox 360 sometime this year—the franchise's 30th anniversary. The next classic Namco game to get the "Namco Generations" DX treatment? Metro Cross! Reply73 repliesLeave a reply


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Global Estimates of Pro-Poor Growth
The main objective of the present paper is to present a cross-country analysis of pro-poor growth in 80 countries in 237 growth spells during the period 1984-2001. To achieve this objective, the paper proposes a new measure of pro-poor growth that captures gains and losses of growth rates due to changes in the distribution of consumption. The gains imply pro-poor growth, while the losses imply anti-poor growth. The statistical test carried out in the paper shows that regional location of countries has a significant association with the pro-poorness of growth. The paper also attempts to test for the association between growth patterns and certain variables that the literature has identified as significant determinants of growth and inequality. Out of many variables, the paper focuses on four, namely, inflation, the share of agriculture in GDP, openness to trade, and the rule of law.
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|Date of creation:
|Oct 2006
|Publication status:
|Published by UNDP - International Poverty Centre, October 2006, pages 1-27
|Contact details of provider:
| Web page: http://www.ipc-undp.org
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Daniel Kaufmann & Aart Kraay & Massimo Mastruzzi, 2006.
"Measuring Governance Using Cross-Country Perceptions Data,"
in: International Handbook on the Economics of Corruption, chapter 2
Edward Elgar Publishing.
- Kaufmann, Daniel & Kraay, Aart & Mastruzzi, Massimo, 2005. "Measuring Governance Using Cross-Country Perceptions Data," MPRA Paper 8219, University Library of Munich, Germany.
- Pierre-Richard Agénor, 2004.
"Macroeconomic Adjustment and the Poor: Analytical Issues and Cross-Country Evidence,"
Journal of Economic Surveys,
Wiley Blackwell, vol. 18, pages 351-408, 07.
- Agenor, Pierre-Richard, 2002. "Macroeconomic adjustment and the poor : analytical issues and cross-country evidence," Policy Research Working Paper Series 2788, The World Bank.
- Atkinson, A B, 1987. "On the Measurement of Poverty," Econometrica, Econometric Society, vol. 55(4), pages 749-764, July.
- Son, Hyun Hwa, 2004. "A note on pro-poor growth," Economics Letters, Elsevier, vol. 82(3), pages 307-314, March.
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Summary | Excerpt | Reviews | Beyond the book | Readalikes | Genres & Themes | Author Bio
The Coral Thief is an epic tale of change, love, and science set against the backdrop of post-Revolutionary France. Napoleon has just been deposed, and France is wrestling with an identity crisis. Will the values of the revolution - independence, freedom, brotherhood - take pre-eminence, or will the country revert to its monarchial tradition? Alongside these philosophical and political debates, similar ones are being waged in the realm of science. Are species static, non-changing, much like the centuries-old tradition of kingship, or do animals change to adapt to their environments, similar to the idealistic revolutionaries? Wide-eyed and anxious to learn, Daniel Connor travels from staid Edinburgh to the hotbed of Paris, the center of the political, philosophical, and scientific debates that will effect change across Europe. In his purse he ...
About the Author
Rebecca Stott was born in Cambridge, England in 1964 and attended the Hove High School for Girls before studying English and Art History at York University, where she also earned her M.A. and Ph.d. The Coral Thief is her second work of fiction after the critically-acclaimed Ghostwalk, a novel set in Cambridge. In addition to her novels, Rebecca is the author of several academic works on Victorian literature and culture, two books of nonfiction, a biography of Charles Darwin and a cultural history of the oyster. She currently works as a Professor of English Literature and Creative Writing at the University of East Anglia in Norwich, England for half of the year. The other half is spent as a freelance writer and broadcaster. She is currently working on a nonfiction book about the first evolutionists, the heretics and infidels behind The Coral Thief, and a historical novel...
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