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GMT Games
Commands & Colors: Ancients allows you to re-fight epic battles of the ancient world. Here the focus is on the two rivals for power in the Western Mediterranean – Carthage and Rome. Will you, as Hannibal, triumph over larger Roman armies; or as Scipio Africanus, will you beat Hannibal with newer tactics of your own?
The Greeks & Eastern Kingdoms is the first expansion to Commands & Colors: Ancients.
The Roman Civil Wars will feature familiar units with new capabilities.
Imperial Rome is the fourth expansion for Commands & Colors: Ancients.
Commands & Colors: Napoleonics allows you to re-fight epic battles of the Napoleonic era. In this core volume, the focus is on the French and the British, two bitter rivals in the struggle for European preeminence during the time of Napoleon.
In this expansion you will find 18 historical scenarios that focus on Peninsular battles fought by the Spanish army from 1808 to 1813, plus all the new units you'll need to field for these engagements
The Spartan Army expansion features over 20 scenarios, which focus on a period of time from 669 BC to 338 BC.
EotS is a strategic level look at the entire War in the Pacific from the attack on Pearl Harbor until the surrender of Japan.
The U.S. Civil War is a 2-player strategic-level war game of the American Civil War.
Next War: India-Pakistan , the next volume in GMTs series of Next War games and a follow-on to Next War: Korea, allows players to fight a near future war between India and Pakistan.


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Jennifer Leong, MD
Specialties:Liver Medicine, Liver Transplantation
Transplant Hepatology
American Board of Internal Medicine
Clinical Focus
- Cirrhosis
- Colonoscopy
- Endoscopic Band Ligation
- Esophageal Varices
- HIV Coinfection In Viral Hepatitis
- Hepatitis B
- Hepatitis C
- Liver Biopsy
- Liver Transplant
- Toxic Hepatitis
- Upper GI Endoscopy
MD, New York University School of Medicine
Residency, Internal Medicine, Bellevue Hospital Center
Fellowship, Gastroenterology, North Shore University Hospital at Manhasset
Fellowship, Transplant Hepatology, Mount Sinai School of Medicine
- A Phase 2 Randomized Open-Label Study to Evaluate the Safety and Efficacy of GS-4774 in combination with Tenofovir Disoproxil Fumarate (TDF) for the treatment of subjects with chronic hepatitis B and who are currently not on treatment
Subjects are being asked to take part in a clinical research study involving an experimental vaccine named GS-4774 in combination with Tenofovir Disoproxil Fumarate (TDF) for the treatment of chronic hepatitis B.
GS-4774 is not approved in any country for the t...
Siddiqui U, Bini EJ, Chandarana K, Leong J, Ramsetty S, Schiliro D, Poles M. Prevalence and impact of diarrhea on health-related quality of life in HIV-infected patients in the era of highly active antiretroviral therapy. Journal of clinical gastroenterology; 41(5).
Feldstein RC, Leong J, Devito B. Gastric outlet obstruction caused by replacement gastrostomy tube. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008 Jul; 6(7).
Leong J, Rascon MA, Kaushik N. Multifocal angiosarcoma of the gastrointestinal tract. Endoscopy 2008 Sep; 40 Suppl 2.
Leong J, Rascon MA, Kaushik N. Multifocal angiosarcoma of the gastrointestinal tract. Endoscopy 2008 Sep; 40 Suppl 2.
Leong J, Fung-Liu B. A case report of nephrotic syndrome due to intake of certolizumab pegol in a patient with Crohn's disease. The American journal of gastroenterology 2010 Jan; 105(1).
Leong J, Zhou M, Jacob A, Wang P. Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways. Life sciences 2010 May; 86(19-20).
Zhou M, Wu R, Dong W, Leong J, Wang P. Accelerated apoptosis contributes to aging-related hyperinflammation in endotoxemia. International journal of molecular medicine 2010 Jun; 25(6).
Leong J, Im GY. Evaluation and selection of the patient with alcoholic liver disease for liver transplant. Clinics in liver disease 2012 Nov; 16(4).
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.

subset: commoncrawl


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Please let me know if you have a solution for gizzza, this issue is stopping me in my tracks from being able to use this template. Can the top nav bar categories be converted over to just links versus automatically grabbing the stores categories?


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Lorne Coachman Inn
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How has this hotel rated in the past?
- Room service
- Free High-Speed Internet
- Wheelchair accessibility
- Kitchenette
- Free parking
Photos of Lorne Coachman Inn
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- Free High-Speed Internet
- Wheelchair accessibility
- Free parking
- Kitchenette
- Room service
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Travel Blogs from Lorne
Took our time this am getting started. I think we all needed some down time. I think this was the morning we saw the birds on the deck that I described in yesterday's blog. But oh well it happened no matter what morning it was! Leigh did some maintenance work, Al read, Dave did sudoku and I spent some time on the deck enjoying the view, the sun and I think the birds! Helen and Sandi enjoyed some sister time. Around 10 Leigh took Al and Dave on an 8 ...
Day 4 - Kangaroos, Koalas and Wombats... oh my!
... out of your hand (kanagaroo food available for purchase at the door) - they are so adorable! And even more adorable are the Koala Bears, which we arrived just in time for the educational talk about them and be able to touch them (very dense fur but soft). We also learned about wombats and got to pet them (coarser hair), as well as learning about Tasmanian Devils (didn't pet them!). The Tasmanian Devil talk was right at ...
The Great Ocean Road
... It was so much fun and it was also my first time hooping in the dark! (my hoop glows!!) The highlight of the night was when I pulled out the pack of GIANT marshmallows my host mum got me to make S'mores! All the other Americans got super excited and we were all really happy to share the goodness of S'mores with those who had never had one! I was finally able to find Hershey's chocolate but unable to find Ghram crackers even after searching ...
Warrnambool to Lorne
... to Seeker Lover Keeper, suddenly she shuffled to Tool and things then became a great deal faster! Finally I get to use the sides of my tyres. The $111 mystery hotel I booked online this morning turned out to be a ripper! Staying at the Mantra in Lorne which is right on the beach. Doing it tough right now laying on my king size bed... Plans for tomorrow? Hmmm not sure yet. I'm definitely riding back along the Great Ocean Road. After that I'm not sure yet. Good way to be ...
The Great Ocean Road
... night in Apollo Bay. The wind was absolutely howling and the rain continued into the evening and through the night. We ran a load of laundry to wash and dry our damp clothes as we cooked a tasty meal of steak, mushrooms with balsamic reduction, garlic bread, asparagus, and rice. It was a really good hearty meal that had become a staple for us in Australia as we could cook all of it on the BBQ. The next morning as we drove towards the lighthouse at Cape Otway we ...


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James B. Comey
News about James B. Comey, including commentary and archival articles published in The New York Times.
Trump Denounces F.B.I. Over Leaks, Demanding Investigation
The criticism followed a report that the White House asked the bureau to rebut an article about Trump associates and Russian intelligence officials.
February 24, 2017, Friday
A Test for Comey, McCain and the G.O.P.
Republican leaders remain the most important bulwark against national calamity.
February 16, 2017, Thursday
On the Road to Another Watergate?
Michael Flynn has resigned. Now expect the investigations to begin.
February 15, 2017, Wednesday
Trump Is Said to Keep James Comey as F.B.I. Director
President Trump has decided to retain Mr. Comey as head of the agency that is leading an inquiry into ties between Trump associates and Russia's government.
January 24, 2017, Tuesday
Democrats Confront F.B.I. Chief at Closed-Door Intelligence Briefing
They demanded to know why James B. Comey made disclosures about the Hillary Clinton email investigation, but refused to say whether the F.B.I. was investigating Donald J. Trump.
January 13, 2017, Friday
Trump National Security Adviser Called Russian Envoy Day Before Sanctions Were Imposed
Lt. Gen. Michael T. Flynn reached out to the Russian ambassador the day before sanctions were imposed for election meddling.
January 13, 2017, Friday
Comey Letter on Clinton Email Is Subject of Justice Dept. Inquiry
The department's inspector general will look into James B. Comey's hotly debated decision to inform Congress about a new review of the Hillary Clinton email case.
January 12, 2017, Thursday
America Becomes a Stan
Rule of law is for the little people.
January 2, 2017, Monday
Clinton Backers Cry Foul Over What F.B.I. Considers Common Procedure
While the F.B.I. stuck with its decision not to pursue charges against Hillary Clinton, agents believed they needed to examine newly discovered emails, just to be certain.
December 21, 2016, Wednesday
Judge Orders Release of Some Documents Related to Clinton Email Inquiry
A federal judge in Manhattan said a government search warrant and supporting documents belonging to Huma Abedin, a top aide to Mrs. Clinton, should be made public.
December 19, 2016, Monday
Rss Feeds On James B. Comey
Subscribe to an RSS feed on this topic. What is RSS?
Get Alerts On James B. Comey
Receive My Alerts e-mails on topics covered on this page.More Alerts >>


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Lot 72: Corina Lecca (1908 - 1990) Muki
Opere, maeștri, mărturii / Masterpieces, Old Masters, Manuscripts
by Goldart
19 October 2016
Bucharest, Romania, RomaniaLive Auction
Corina Lecca (1908-1990) Please Register/Login to access your Invaluable Alerts
Past Lot
Looking for the realised and estimated price?
creion conte brun cu accente de pastel alb/hârtie, semnat dreapta jos (T.A.P.) /
brown pencil and white pastel on paper, signed lower right (T.A.P.)
Dimensions: 20 x 26 cm
Artist or Maker: Corina Lecca (1908 - 1990)
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Ruby on rails developer for mail web service
- Status Closed
- Budget min €5000 EUR
- Total Bids 17
Project Description
I'm looking for a developer to build a relative simple but complete mail sending web service with sign up, login, editing of html mail templates, payments etc. Think 37signals feature and focus wise. Simple, easy to use and to the point not trying to solve all your problems just.
I will supply complete design in PSD and description of every user event. There will be probably still be some logic holes to fill as it is difficult to estimate every conceivable case. I will also suggest choice of technique, plugins etc but require the developer to make qualitative choices when it comes to those things.
You will be responsible for building a great web service including how to handle hosting and making sure the code can be further developed and that the service should be able to handle at least thousands of users creating mailing lists, mails and sending emails. I encourage feedback on things if you have opinions on how the service should work.
You will work tight with me through Skype, Google docs, Dropbox and Asana or similar. I encourage that you ask quickly if there is any questions and that we solve every obstacle fast and efficient.
If you get the job, the first thing we would do together would be to estimate the time and set a clear deadline for the project.
If the project is successful and I feel you have done a great job there will be lots of more work over time on this and other projects.
To apply
Please provide samples of web services you have built before preferably with sending of mails, user login/signup and payments. Also please describe how you would tackle this project and making sure you deliver a great end product.
About me
I'm a web designer and entrepreneur who designs web sites for clients but also work on my own projects. I'm looking at building a portfolio of smart, easy to use web services and this is the first one. Let's do great things together!Get free quotes for a project like this
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


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Cloudbreakers Gameplay 1 iOS / Android
By: Jan Tom�ik
Genre: Adventure
Video Tips
Let's play Cloudbreakers! This is part 1 of my walkthrough for the iOS and Android game Cloudbreakers.
Still need help to finish Cloudbreakers gameplay?
I will update this post with more tips and tricks, so please bookmark this page and keep on checking in!
If you have any questions, feel free to ask for extra help in the comments section.
Hit like if this helped you!
Visit Cloudbreakers walkthrough page for level videos, tutorials, cheats and more.


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$2,295 2 bed 710 Colorado St, Austin TX, 78701
$2,295 2 bed
710 Colorado St, Downtown, Austin, 78701
Commute to Downtown Austin
This apartment is in the Downtown neighborhood in Austin. Nearby parks include Wooldridge Square, Wright Field and Republic Park.
710 Colorado St has a Walk Score of 98 out of 100. This location is a Walker's Paradise so daily errands do not require a car.
Beautiful, modern condominium in the heart of downtown Austin. Open air floor plan. Amazing views from the living room and bedrooms. Brand new appliances. Truly stylish, luxury living in the middle of downtown.
Owner/manager tools | Report bad listing | From rentjungle.com
Daily errands do not require a car.
Transit is convenient for most trips.
Mostly flat, excellent bike lanes.
About your score
Explore how far you can travel by car, bus, bike and foot from 710 Colorado St.
710 Colorado St has excellent transit which means transit is convenient for most trips. Car sharing is available from Zipcar, RelayRides and Getaround.
Bus lines:
17 Cesar Chavez
0.0 mi
801 N Lamar S Congress
0.0 mi
803 Burnet/S Lamar
0.0 mi
481 Night Owl North Lamar
0.1 mi
7 Duval / Dove Springs
0.1 mi
20 Manor Rd/Riverside
0.1 mi
37 Colony Park/Windsor Park
0.1 mi
1 Metric/South Congress
0.1 mi
5 Woodrow/South 5th
0.1 mi
10 South 1st/Red River
0.1 mi
Car shares:
Bike shares:
710 Colorado St compared to all of Austin.
Average crime area.
Higher crime area.
How do you feel walking near 710 Colorado St?
Thanks for your feedback!
View all Downtown apartments on a map.
Popular apartment searches include fitness, pool and hardwood floor.
Search for homes in Austin or find a Austin real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
710 Colorado St is in the Downtown neighborhood. Downtown is the most walkable neighborhood in Austin with a neighborhood Walk Score of 90.
Moving to Austin from another city? View our moving to Austin guide.


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© Copyright 2017 Chrysta. All rights reserved.
Status: Finished
Genre: Gay and Lesbian
I really enjoyed this it was somethin u went through personally and dat wat I love about it.....
touching story.
Book / Romance
Book / Horror
Book / Horror
Paste the link to picture in the entry below:
Paste the link to Youtube video in the following entry:
Cannot annotate a non-flat selection. Make sure your selection starts and ends within the same node.
An annotation cannot contain another annotation.
There was an error uploading your file.


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Scallop Quenelles With Red Pepper Sauce
|Sea scallops
|1 Pound
|Dry vermouth
|1 Tablespoon
|3⁄4 Teaspoon
|White pepper
|1⁄8 Teaspoon
|Heavy cream/Whipping cream
|1⁄2 Cup (8 tbs)
|Instant mashed potato flakes
|1⁄4 Cup (4 tbs)
|Red pepper sauce
|1 Cup (16 tbs)
|Boiling water
|1 Cup (16 tbs)
1. Prepare quenelles: In food processor with knife blade attached, blend scallops, eggs, vermouth, salt, and white pepper until scallops are very finely chopped, scraping side of container as necessary. Add heavy or whipping cream and mashed-potato flakes, and blend just until mixed. (To use blender, place 1/2 pound scallops, 1 egg, and 1/4 cup heavy or whipping cream in blender container; blend at high speed until very finely chopped. Spoon into large bowl; repeat with remaining scallops, egg, and heavy cream. Stir in vermouth, salt, pepper, and mashed-potato flakes until smooth.)
2. Grease 13" by 9" baking dish. Using 2 large spoons, shape scallop mixture into 8 large ovals. Gently arrange quenelles in baking dish. Set aside.
3. Prepare Red-Pepper Sauce; keep warm.
4. Pour boiling water around quenelles in baking dish; cover dish with waxed paper. Cook at high (100% power) 4 to 5 minutes, just until quenelles are set, rotating baking dish after 2 minutes.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1220 Calories from Fat 561
% Daily Value*
Total Fat 63 g96.7%
Saturated Fat 33.1 g165.6%
Trans Fat 0 g
Cholesterol 746.8 mg248.9%
Sodium 2953.6 mg123.1%
Total Carbohydrates 38 g12.6%
Dietary Fiber 4.8 g19.4%
Sugars 9.2 g
Protein 96 g192.1%
Vitamin A 127.7% Vitamin C 144.5%
Calcium 25.4% Iron 19.9%
*Based on a 2000 Calorie diet


text:
Forum Posting Single Account Management On Leading SEO, IM Forum
- Status Closed
- Budget N/A
- Total Bids 16
Project Description
We require a person to take over the management of a specified account We own on a Leading SEO, Internet Marketing, Make Money Online Forum.
Applicants must have a very good knowledge in all of the above areas with the ability to make related and engaging posts.
Applicants must have a high standard of both written and spoken English.
Applicants must be available to post a minimum of 10 posts per day or 70 posts per week.(This is minimum)
Our maximum posting limit would be based around the protection of the account and our weekly/monthly budget for the job.(Between $10-$20)
Posts must be made to look natural and real with a minimum of 20 words.
(This is not a rule. We just don't want useless posting like "thanks" "Nice information" "good post")
Apart from these conditions the job is very simple.
We are going to pay you to be an active member on a forum.
What we need in your offers is your price quote per post. And an estimate on how many posts you would have time to create each day.
We are obviously looking for the best value, But at the same time we are looking for good quality.
This is an easy task for anyone who wishes to supplement their online income by simply getting involved in discussions that interest them on a forum. And would not take much of your time to do each day.
The contract will also continue long into the future with the successful applicant and will also be expanded into other forums if We are happy with your work and We are successful in our campaigns.
So be smart about your bids.Get free quotes for a project like this
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
There's something very weird about the empty store I'm standing in. It's not that it's nearly abandoned (in the middle of the bustling SoHo neighborhood in New York, no less) or that the finishing touches are still being fine-tuned in front of me. What's strange is that it hasn't existed until now.
That's because Sonos, the high-fidelity smart speaker company opening this sleek, Apple-esque shop on Greene Street in SoHo, sells products that you need to experience to fully understand. When the Sonos store officially opens its doors on July 19, the Santa Barbara-based company is hoping that all this extra overhead and effort pays off in exactly that fashion: convincing people that spending several hundred dollars on a smart speaker system is worth it.
"It's a very unusual experience," says Dmitri Siegel, vice president of global brand and executive creative director for Sonos. "We've devoted almost all of the floor plan to these listening rooms. You'll be able to go in there with whoever you come in with, and we're going to leave you alone and let you listen to music."
For the unfamiliar, Sonos makes a handful of different Wi-Fi-connected, high-fidelity speakers that can be linked together to create an immersive, multi-room listening experience. It's sort of like your friend's portable Bluetooth speaker, but without the portability or the Bluetooth. Instead, Sonos is designed to be used in the home or office and relies on Wi-Fi (along with its own proprietary smartphone software) to pump music throughout whichever parts of the building you've decided should have a soundtrack. One can start simple with the compact $200 Play:1 speaker, splurge for the higher-power Play:3, Play:5, or their home theater sound bar. Or hey, go crazy, and drop a few grand and string a bunch of them together. YOLO.
While it's possible to hear a Sonos speaker in a store like Best Buy or Target, it doesn't quite capture anything resembling the experience you would have at home, because until something truly borderline apocalyptic happens, you don't live inside an abandoned big-box retail store. The shape and acoustics of your home are very, very different from that of a Target.
For that reason, Siegel and the Sonos team, with some outside help, designed a space that is made to feel—and sound—more like a home than a store. Indeed, when you walk into the fairly minimalist, two-story retail space, you won't see a row of cash registers with lines of people flowing from them. Instead, after walking by the enormous portrait of famed record producer (and Sonos board member) Rick Rubin on the wall, you'll see a row of seven listening rooms, each one sonically isolated from the outside world with a steel-framed door made of thick, beveled glass. Inside each of the rooms—which are separated from one another by multiple layers of acoustic sheet rock—are comfortable furniture, bookshelves, knickknacks, and design details meant to make prospective customers feel right at home, even if most of us don't live in homes that look like we went on a high-end Etsy shopping spree with an interior design snob. Oh, and there are speakers, of course.
After a brief introductory video, visitors are encouraged to play around with the Sonos software and queue up the music they love, alternating between different combinations of speakers to hear what each sounds like. And the team has gone to great lengths to ensure the results are as pleasing as possible. These rooms have been acoustically designed with, for instance, walls that absorb and reflect sound in just the right way. Even the books are placed strategically—some of them with the spines facing inward on the shelf—to squeeze every last drop of potential sound quality from the rooms. Sonos's "sound experience leader" Giles Martin—the record producer best known for taking up the mantle from his famous father, George Martin, in remastering The Beatles' music—worked closely with Hilmar Lehnert, the company's head audio engineer, to translate the physical details of each room into the best possible sonic results.
Of course, most people's homes are not acoustically tuned by world-class engineers, but it's not as though a Play:5 or Play:1 is going to sound like a trash can once it gets back to your home. Still, it's worth keeping in mind that results may vary once a customer gets their speakers home.
Sound isn't the only sensory detail obsessively perfected by the store's designers, although it is the biggest one. Adorning the walls of the store are artifacts that nod to chapters of New York's musical history. Upstairs, you'll find a collection of rare music zines from archivist Arthur Fournier. Downstairs, there's a glass-encased sampling of mixtapes from the personal collection of Sonic Youth's Thurston Moore. In one of the listening rooms, a wall-sized mural by longtime Village Voice illustrator Mark Stamaty recreates the crowded chaos of SoHo in cartoon form.
If it sounds like Sonos obsessed over every last detail of the store, it's because they did. As a company with rigorous hardware design planted firmly in its DNA, the company spent a long time—probably longer than they expected—crafting a physical experience that's much bigger and more nuanced than a speaker that sits on the shelf. For several months, the company operated a secret store prototype in Carson, California, where it build several iterations of the store's design and ushered in user experience researchers and focus groups to help them figure out how to build a retail environment that's anything but conventional.
Indeed, as Siegel tells me, the store's goal isn't to see as many units flow out the front door as possible. "We know it can be a long buying decision-making process," says Siegel. "It's not generally a spontaneous purchase." To that end, the kiosks in the listening rooms allow customers to email themselves details about the speakers so they can do more research at home later.
The store isn't even expected to drive a huge, short-term boost in sales, necessarily. That would be a welcome outcome, of course, but the company sees plenty of other value in what they just built. For starters, it's great for R&D. "We're going to take what we learn from Greene Street and use it to inform us everywhere we show up, from our studio in London to Best Buy."
With its store set to open its doors, Sonos can now turn its attention to other pressing matters. The unexpected success of voice-controlled smart speakers like Amazon Echo (and upcoming counterparts from Google and, as rumor has it, Apple) clearly caught Sonos off-guard. While the first iteration of the Echo doesn't sound nearly as good as Sonos or allow synced, multi-room playback, the use of voice control is a user interface shift that Sonos knows it needs to embrace and is now reportedly working on integrating voice control into its products. Software is another challenge: As beloved as its hardware is by many Sonos diehards, its proprietary app for controlling music playback has grown stale and seldom gets much love. Presumably, a redesign of its software is on the list of projects to tackle next. But for now, the company has plenty of work to do in SoHo.
related video: Rebecca Minkoff's Store Of The Future Will Blow Your Mind
Slideshow Credits: 01 / Courtesy of Sonos;


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Richard Spires resigned as DHS CIO on May 7.
Richard Spires, who had been on leave for nearly two months, resigned his position as Department of Homeland Security Chief Information Officer on May 7.
In an e-mail sent to various DHS officials and shared with FCW by a source within DHS, Spires wrote:
"Today I have resigned from the Department of Homeland Security. It has been a privilege to work with such a stellar group of public servants to support such important missions. I have served as the Department's CIO for more than 3 1/2 years, and I take pride in working with you to have IT more effectively support the Homeland Security missions and business as we also have worked to more efficiently deliver our services. I have learned much from you and I will miss you."
A DHS official, speaking on background, told FCW that the department had accepted Spires resignation, and that Deputy CIO Margie Graves continues to serve as the acting CIO.
Spires' leave was paid, and his last day receiving government pay will be May 17.
Rumors have swirled since news of Spires' leave broke on April 1, ultimately leading House Homeland Security Committee Ranking Member Rep. Bennie Thompson (D-Miss) to send DHS a formal inquiry asking the department to provide an explanation for Spires "being placed on either voluntary or non-voluntary leave on March 15."
The inquiry, which also asked DHS to provide Graves' job history, instructed DHS to respond by May 6, but DHS did not meet that deadline, according to a House Homeland Security Committee official.
DHS has officially maintained that Spires went on elected leave beginning March 15, yet several sources have told FCW Spires' leave was not of his choosing, and may have been precipitated by fundamental disagreements over CIO's authority over department-wide budgeting and purchasing of commodity IT.
Spires was also vice-chairman of the federal CIO Council, but requests for comment to the Office of Management and Budget regarding how that position will be filled were not returned.
About the Author
Frank Konkel is a former staff writer for FCW.
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Save the date for 28th annual Federal 100 Awards Gala.
March 30, 2017
The Department of Commerce is revising its confidentiality agreement for statistical data survey respondents to reflect the fact that the Department of Homeland Security could see some of that data if it is captured by the Einstein system.
In a Feb. 17 memo, Defense Secretary Jim Mattis told senior leadership to establish teams to look for duplication across the armed services in business operations, including in IT and cybersecurity.
State election officials had more questions than answers after a Department of Homeland Security presentation on the designation of election systems as critical U.S. infrastructure.
The government desperately needs younger talent to replace an aging workforce, and experts say that a freeze on hiring doesn't help.
The Department of Veterans Affairs will test an internally developed scheduling module at primary care sites nationwide to see if it's ready to service the entire agency.
After missing in the last Congress, drafters of a bill to encourage cloud adoption are looking for a new plan.
Well DHS has been mandating components to use the Data Centers and that project is a mass center of inefficiency and a HUGE increase in costs. Seemed to be against the DHS efficiency attempts.
I can understand Richard's position given both ClingerCohen Act and new FITARA legislation that gives the agency CIO the authorities he was requesting. Richard's participation in the IT Acquisition Advisory Council (IT-AAC) Leadership Roundtables was very enlightening and demonstrated his understanding of both the challenges and opportunities. Good luck in your new endeavors, I hope your new home will allow you to continue your public service.
This is horrible. Mr. Spires is a great CIO with a clear vision for the future.
This story has been updated since the comment below was posted. DHS did not meet Rep. Thompson's deadline -- but at this point it's unclear whether there is any causation, or simply correlation.
So did DHS respond the Rep Bennie Thompson's request. It was due yesterday. Is this a coincidence?
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Elucidating the factors that control the replication fidelity of DNA polymerases is a goal of great fundamental and practical importance. In order to advance in this direction we will generate realistic atomic-level simulations of the catalysis and replication fidelity of wild-type and mutant DNA polymerases, focusing on DNA polymerase (pol), which is a key player In human base excision repair and has been Implicated in the incidence of cancer. The main strength of our laboratories has been our combined expertise in state-of- the art simulations of enzyme catalysis and catalytic landscapes, with a deep understanding of the available experimental information on the structural and mechanistic underpinnings of the fidelity of DNA polymerases. Our theoretical toolbox includes the empirical valence bond (EVB), the paradynamics that provides effective way of obtaining ab initio quantum mechanical /molecular mechanics (QM/MM) free energy profiles using the EVB as a reference potential, as well as coarse grained (CG) renormalizatlon approaches for exploring long time coupling between the conformational and chemical coordinates. We have also develop and refined effective sampling methods that should allow us to increase the accuracy of the calculated free energies. These computational studies will be applied in concert with the biochemical studies of Project 3 of kinetic effects of mutations of pol and of changes in its substrates. Our simulations will reproduce and/or predict the functional effects of these changes and analyze their origin. At the same time, we will rely on the important structural information from Project 1. The atomic level understanding Of the structure of the transition state for the insertion of a new nucleotide by pol and the malleability of this structure by modifications of the active site will greatly increase the possibilities of effective design of a potent and selective inhibitor of pol .
Our strategies will allow us to explore the effect of mutations (including distant mutations) and realistically simulate the coupling between the conformational changes induced by the binding of dNTP substrate and the formation of the new PO bond by DNA polymerases. We will also explore the change of this coupling and the resulting rate-limiting transition states due for the right and wrong dNTP substrates
|Kirby, Thomas W; Derose, Eugene F; Beard, William A et al. (2014) Substrate rescue of DNA polymerase ? containing a catastrophic L22P mutation. Biochemistry 53:2413-22
|Wu, Sangwook; Beard, William A; Pedersen, Lee G et al. (2014) Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site. Chem Rev 114:2759-74
|Prasad, Rajendra; Horton, Julie K; Chastain 2nd, Paul D et al. (2014) Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair. Nucleic Acids Res 42:6337-51
|Freudenthal, Bret D; Beard, William A; Wilson, Samuel H (2014) Watching a DNA polymerase in action. Cell Cycle 13:691-2
|Towle-Weicksel, Jamie B; Dalal, Shibani; Sohl, Christal D et al. (2014) Fluorescence resonance energy transfer studies of DNA polymerase ?: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. J Biol Chem 289:16541-50
|Beard, William A; Wilson, Samuel H (2014) Structure and mechanism of DNA polymerase ?. Biochemistry 53:2768-80
|Oertell, Keriann; Chamberlain, Brian T; Wu, Yue et al. (2014) Transition state in DNA polymerase ? catalysis: rate-limiting chemistry altered by base-pair configuration. Biochemistry 53:1842-8
|Hwang, Candy S; Kashemirov, Boris A; McKenna, Charles E (2014) On the observation of discrete fluorine NMR spectra for uridine 5'-?,?-fluoromethylenetriphosphate diastereomers at basic pH. J Org Chem 79:5315-9
|Seamon, Kyle J; Hansen, Erik C; Kadina, Anastasia P et al. (2014) Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. J Am Chem Soc 136:9822-5
|Sassa, Akira; Ça?layan, Melike; Dyrkheeva, Nadezhda S et al. (2014) Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem 289:13996-4008


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Kuendu Beach Resort
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Monday 'n' Tuesday
... cup of tea from the food court. He is very good to me.... Hope everyone is going okay. Two more sleeps and we're back on land, home on Thursday. This has to be one of the most relaxing holidays we have had. Beth While Beth sipped her tea I endeavoured to assist the ship make its way home by going to the gym, getting a treadmill facing in a south westerly direction (towards Sydney) and walking 7 ...
L'île des Pins/ The Isle of Pines
... Kanak after 6pm (2nd subject of frustration). The tribes are divided into clans and sub clans and those are made up of families and old stories of divisions still taint relations between Kanaks. I had the oportunity to lunch in a family, the father is Caledonian from Indonesian descent and the wife is from Brittany, France...and this is where I learned all these things. The father is a " gendarme" but very discreet. The ambiance here is very different from Grande ...
Nouméa, France ou/ or Nouvelle-Calédonie?
... et les Européens se tendent et tournent à la violence. Négociations qui aboutissent sur les accords de Matignon ( 1988), prévoyant la mise en place d'un statut transitoire de 10 ans devant se solder sur un referendum d'autodétermination. En 1998, l'accord de Nouméa accorde une autonomie forte et repousse le referendum entre 2014 et 2017. Entretemps la population Kanak est passėe à 40% de l'ensemble de la population. At noon, after a farewell ...
Jour 1
Fresh multicoloured manicures and best
travelling clothes. A very excited group. Another girls school from Cronulla
was travelling on the same plane as us and the girls were all mixed up in
different seats. Frenchness started straightaway with the French newspaper,
French movies and lots of NC people returning home.
World Cup @ Piscine Naturelle
... br>
We filled the tank at the only station on the island - great prices :)
Baguettes for dinner with tomatoes and cheese ... I went to the main dining room to get some space and wifi ... turns out the actual 'meals' others were eating looked really good...like actual food ... I think we will need to go for it and eat a meal tomorrow at some point.
Sand and sun await us for tomorrow...


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Testing Subsets of Structural Parameters in the Instrumental Variables
We develop Lagrange multiplier and likelihood ratio statistics to test hypotheses on subsets of the structural parameters in an instrumental variables regression model. The asymptotic distributions of these statistics are robust to instrument quality. A key assumption is, however, that the instruments are valid for the remaining endogenous variables. We show that the statistics lead to 95% confidence sets for the return on education in data from Card (1995) that are considerably different from the confidence sets that result from the 2SLS Wald statistic, which is the common statistic used in the literature. © 2004 President and Fellows of Harvard College and the Massachusetts Institute of Technology.
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Volume (Year): 86 (2004)
Issue (Month): 1 (February)
Pages: 418-423
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The Zookeeper's Daughter(2016)
A novel by Elise Broach
Twelve-year-old Lizzie Durango and her dad have always had a zoo to call their home. Lizzie spends her days watching the animals and taking note of their various behaviors. Though the zoo makes for a unique home, it's a hard place for Lizzie to make lasting friends. But all this changes one afternoon when she finds Tyler Briggs, a runaway who has secretly made the zoo his makeshift home. The two become friends and, just as quickly, stumble into a covert investigation involving the zoo wolves who are suddenly dying. Little do they know, this mystery will draw them into a high-stakes historical adventure involving the legend of John Muir as they try to navigate safely while lost in Yosemite National Park.
A Christy Ottaviano Book
Genre: Children's Fiction
A Christy Ottaviano Book
Genre: Children's Fiction
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Task and Task<TResult>, Waiting and Continuations
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Join Danny Shih as he introduces the heart of the Task Parallel Library (TPL). He'll talk about two core types (Task and Task<TResult>) and two functionalities that they support (waiting and continuations).
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Tip 1: Async void is for top-level event-handlers only
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A CELEBRATION OF MINISTRY for Intl. Prelate Dr. Lloyd Benson, Sr.
World Link of Churches & Ministries, Inc.
Multiple Dates
Event Details
Life Cathedal Worship Center invites you to join in the celebration of Intl. Prelate Dr. Lloyd Benson, Sr., for five awesome years of local ministry in the Gonzales, LA area. Many lives have been impacted and changed through this man of God.
Sunday, October 20th at 8:00 a.m. and 5:30 p.m. is the date and times of the celebration. Come, see and hear what God is speaking through these dynamic speakers. Bring a family member, co-worker or friend with you. We look forward to seeing you there!
Life Cathedral Worship Center
2103 South Philippe Avenue
Multiple Dates
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World Link of Churches & Ministries, Inc.
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Charge Nurse (RN) Salary
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Job Description for Charge Nurse (RN)
A charge nurse most often works in a hospital or a similar health-care environments such as nursing homes and other long-term care facilities. A charge nurse is effectively the manager of the department or hospital unit to which they are assigned. Common duties include overseeing operations, monitoring admissions and discharges, and directing and overseeing the activities of the nursing and support staff. A charge nurse also often is responsible for direct patient charge, as well as any additional duties assigned to the role of charge nurse.Read More...
A charge nurse usually is expected to plan and maintain the schedule of the nursing and support staff and may work on the unit's budget. The charge nurse often has the responsibility of monitoring inventories of supplies and medicines. Typical coworkers include nurses, certified nurses assistants, physical therapists, nutritional aides, doctors, and respiratory therapists. The charge nurse often works closely with the unit manager.
Above-average communication skills are mandatory for charge nurses. Completion of training as a registered nurse is required through completing a bachelor's or associate's degree. A charge nurse usually works 12-hour shifts in a hospital setting. Some charge nurse may work a shorter shift, closer to 8 hours, while some charge nurses may work a 16-hour shift. Often, charge nurses working 12-hour shifts or longer can expect to work three days a week, but this will vary depending on the individual and the facility.
Charge Nurse (RN) Tasks
- Coordinate the activities of the unit and assign work to the nursing staff.
- Institute emergency procedures as necessary.
- Communicate patient status to incoming nursing shift and to physicians.
- Educate the nursing staff on patient care.
- Supervise the delivery of care in a nursing unit.
Common Career Paths for Charge Nurse (RN)
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It's not very common for RN Charge Nurses to move on to become Family Nurse Practitioners. Average pay for a Family Nurse Practitioner is $82K annually. Clinical Nurse Managers or Nursing Managers are common next-step roles for RN Charge Nurses moving up in their careers; annual pay for Clinical Nurse Managers is $8K higher on average, and it's $9K higher for Nursing Managers.
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HCA, Inc., DaVita Inc., Fresenius Medical Care Holdings, Inc., Golden LivingCenters, and Fresinius are some prominent firms with considerable interest in employing a large team of RN Charge Nurses. The Veterans Administration (United States) offers the largest salaries in town — $78K on average. RN Charge Nurses can also look forward to large paychecks at WellStar Health System ($75K), Providence Hospital ($73K), and DaVita Inc. ($71K).
Golden LivingCenters offers the lowest pay in the field with a median salary of just $51K. There's also little variation in pay at the company, with pay ranging from $45K to $74K. Also sliding in at the lower end of the scale are Genesis HealthCare ($54K), Kindred Healthcare ($58K), and SSM Health Care ($61K).
Popular Skills for Charge Nurse (RN)
RN Charge Nurses report using a deep pool of skills on the job. Most notably, skills in Operating Room / OR, Labor & Delivery, Birthing, Intensive Care Unit, and Dialysis are correlated to pay that is above average, with boosts between 8 percent and 14 percent. Skills that are correlated to lower pay, on the other hand, include Geriatrics, Hospice, and Pediatrics. Most people experienced in Acute Care also know Medicine / Surgery and Geriatrics.
Pay by Experience Level for Charge Nurse (RN)
Median of all compensation (including tips, bonus, and overtime) by years of experience.
RN Charge Nurses with a lot of experience do not necessarily enjoy more money. The median compensation for relatively untried workers is $58K; in the five-to-10 year group, it's higher at around $64K. RN Charge Nurses bring in $71K after working for 10 to 20 years. More than 20 years of experience mean a somewhat bigger median paycheck of $74K, but it's not much more than what less experienced people make.
Pay Difference by Location
For RN Charge Nurses, working in the bustling city of Los Angeles has its advantages, including an above-average pay rate. RN Charge Nurses will also find cushy salaries in Houston (+24 percent), Chicago (+17 percent), Denver (+16 percent), and Tampa (+14 percent). With compensation 6 percent below the national average, Cincinnati is not known for hefty paychecks and actually represents the lowest-paying market. Employers in Nashville and Indianapolis also lean toward paying below-median salaries (2 percent less).
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Brown Bear, Brown Bear
Curriculum Area: Art
Activity Title: Drawing Brown Bears
Materials Needed: Patterns of bears, paper, patterns of eyes, nose, mouth, crayons, scissors and pencil
Activity Purpose: Encourage children by telling them about brown bears
1.Have the children sit at art table
2.Give each child a brown bear and some eyes, nose, mouth, paper, crayons and scissors.
3.Have children begin drawing their brown bears and coloring them
Conclusion: Ask the children where do brown bears live? What do brown bears eat? What color are brown bears?
© Copyright 2017 lisa2012. All rights reserved.
Status: Finished
Genre: Children Stories
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See all
Smithers Rapra is a leading authority for E&L assessments. Our experts have a proven track record of developing and delivering comprehensive E&L assessments tailored to your specific needs in our FDA registered laboratories.
This expertise derives from Smithers Rapra's 90 year history of working with rubber and plastic materials, our medical and pharmaceutical industry experience and our excellent understanding of analytical chemistry.
The examination of Extractable and Leachable substances is extremely important for the protection of patients and for regulatory documentation destined for authorities such as the FDA and EMA. Find out more about Extractables and Leachables.
Smithers has a wealth of experience to share, to support our clients to effectively and efficiently develop, test, validate and document their products for qualification and regulatory submission. We understand that you have specific requirements that need to be addressed. Understanding E&L regulations, deciding on a suitable test strategy, and meeting timelines and resource restraints, can be a challenge for those new to E&L. Because we know that decisions made early in an E&L study will affect later stages, we can guide you through what is required, and how best to meet your needs, to support your regulatory submission and protect patients. We will:
Each stage of an E&L study is designed with you, to develop a customised service.
As material and E&L experts, we can offer our services on a purely consultative basis. We regularly support
Please contact us to discuss your needs, for more information or to request a quote
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Diabetic macular edema (DME)—a manifestation of diabetic retinopathy1—is the leading cause of vision loss in patients with diabetes.2 It is estimated that by 2020, approximately 1.34 million people in the United States will be affected with vision-threatening diabetic retinopathy.3 Risk factors of DME, including the duration of diabetes, severity of hyperglycemia, hypertension, and hyperlipidemia, are now well established,4 and intensive control of blood sugar, blood pressure, and serum lipids is highly encouraged to prevent and reduce some of the complications seen with diabetic retinopathy.4-6 Once it develops, however, strict control of these systemic factors alone is not sufficient to manage DME.7
In 1985, the Early Treatment for Diabetic Retinopathy Study demonstrated that laser photocoagulation achieved a 50% reduction in risk of moderate visual loss in patients with clinically significant macular edema.8 Since then, laser therapy has become the mainstay of therapy for DME.9 However, concerns surrounding some of the damaging effects of laser therapy (including scar expansion,10 choroidal neovascularization,11 subretinal fibrosis,12 and visual field loss13), as well as its inability to achieve significant visual improvement,9 have inspired researchers to find safer, more effective treatment alternatives for DME.9
In recent years, substantial effort has been devoted to investigating pharmacologic agents for DME, including corticosteroids and vascular endothelial growth factor antagonists (anti-VEGFs).2 The use of corticosteroids, such as intravitreal triamcinolone acetonide (IVTA), is now becoming increasingly common in patients whose DME is refractory to laser therapy.14 In addition, the benefit of IVTA adjunct to laser therapy is also being explored; so far, results from different studies have generated conflicting outcomes, where some have shown an added benefit and others have not.15-18 The most common complications of IVTA are cataract formation and increased intraocular pressure.19,20
To reduce the need for repeated intravitreal injections of corticosteroids—as observed with IVTA—extended- and sustained-release corticosteroid devices, including fluocinolone acetonide-eluting intravitreal implants and dexamethasone drug delivery systems, are currently being considered for DME and have yielded encouraging results.21-24
Anti-VEGF therapies are another class of pharmacologic agents investigated for the treatment of DME. There are currently 4 commercially available anti-VEGF agents: pegaptanib, bevacizumab, aflibercept, and ranibizumab4; the latter is the only one approved by the FDA for DME.25 Ranibizumab, a recombinant humanized monoclonal antibody fragment, gained FDA approval in 2012, based on favorable results from 2 randomized, sham-treatment controlled, 3-year studies.25 In addition, outcomes from other studies showed that ranibizumab either alone or in combination with laser therapy, was more effective than laser monotherapy.18,26,27 Clinical trials with bevacizumab, pegaptanib, and aflibercept have similarly yielded more favorable results when compared to sham or laser therapy.28,29 The safety profile of anti-VEGFs reveals that some patients may experience intraocular pressure elevation and only rarely endophthalmitis, following repeated intravitreal injection.30,31
So the question still stands: Will pharmacotherapy eventually replace laser photocoagulation for DME? With current and emerging pharmacologic agents, evidence suggests that treatment may be headed in that direction. Nevertheless, laser therapy continues to play an important part in the treatment of DME, particularly in clinically significant macular edema.32 Furthermore, the role of combination therapies with laser photocoagulation has yet to be clarified.4


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Carrot and Orange Soup
|1 3⁄4 Pound, sliced
|1 , chopped
|Celery stick
|2 , chopped
|Chicken stock/Vegetable stock
|4 Cup (64 tbs)
|Bay leaf
|1 Tablespoon
|Orange juice
|1 Cup (16 tbs)
|1 Pinch
|Ground black pepper
|To Taste
|1⁄4 Cup (4 tbs)
|Bay leaves
|1 (For Garnish)
Place the carrots, celerv and onion in a pan with the stock and bav leaf.
Cover and simmer for 20 minutes until tender.
Puree the vegetables in a blender or through a sieve.
Blend the cornstarch with a little of the stock and return it to the saucepan with the pureed vegetables, orange rind and juice and nutmeg.
Season to taste.
Bring to the boil and simmer for 3 minutes, stirring.
Pour soup into a serving bowl and decorate with a swirl of cream.
Garnish with bay leaves.
Recipe Summary
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Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1132 Calories from Fat 152
% Daily Value*
Total Fat 17 g25.7%
Saturated Fat 5.8 g29%
Trans Fat 0 g
Cholesterol 32.9 mg11%
Sodium 2101.2 mg87.5%
Total Carbohydrates 212 g70.8%
Dietary Fiber 27.4 g109.6%
Sugars 101.5 g
Protein 38 g75.5%
Vitamin A 2674.4% Vitamin C 310.9%
Calcium 52.7% Iron 36.6%
*Based on a 2000 Calorie diet


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Join the fight against LBD!
Lewy Body Dementia Association volunteer, Kam Aggarwal, is featured in a news story about a brand new LBDA support group in Minn.
Two years had passed since they were last together, so Bill Denk and his four buddies had a lot to talk about. What they didn't have a lot of was time.
Philip Software has developed 'decision support software' for FDG-PET scans, which may assist in diagnosing several types of dementia, including LBD.
MayoClinic.com informs caregivers how to develop a plan to cope with Lewy body dementia.


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Pedigree Dogs Exposed - The Blog
From the makers of Pedigree Dogs Exposed, the latest news and views regarding inherited disorders and conformation issues in purebred dogs.
Wednesday, 25 January 2017
Fighting for air their whole lives
|© Ralph Rückert
Take a good look into this French Bulldog's eyes. He has just woken up from an anaesthetic and the endotracheal that supported his breathing during the procedure is still in place. Dogs always fight it because it makes them gag. But not this dog - and many other brachycephalics. The ET tube has opened his airways, enabling him to breathe properly - probably for the first time in his life.
His story was posted on Facebook last week by a German vet, Ralph Rückert.
I was so moved that I asked Dr Rückert if we could translate it and post it here.
Here's what he wrote:
It might sound implausible, but the French Bulldog in the photo just woke up from anaesthesia. The eyes focus on me and see me. Seconds later we removed the pulse oximeter from the tongue, and the dog rolled itself upright.
Every (every!) other dog will immediately try to dislodge the endotracheal tube at this moment, which is why we usually take it out much sooner. But with Frenchies (and other flat nosed dogs) we leave the tube in position as long as possible, dreading respiratory collapse during the home stretch of their anaesthesia.
This frequently leads to the moment - a moment that regularly sends cold chills down my spine - when you realise that these dogs, while fully conscious, are enjoying the ability to breathe without effort (through a tube) for the first time in their life. I know that I am anthropomorphising unashamedly but nonetheless: when you pull the tube eventually, the wheezing starts up again and you see - I swear to high heaven - a glaze of resignation and disappointment fall over their eyes that were previously bright with fascination.
This is a moment where the lifelong - and too often ignored – suffering of many brachycephalic dogs becomes crystal clear to see. Sadly it is a moment only vets witness. The first time I noticed this phenomenon, I was inclined to dismiss it as my own sentimental fabrication. But as time passed, I heard stories of the same curious and touching moment from several colleagues with a lot of experience with flat nosed breeds. You absolutely have to ask yourself honestly what it means when a dog prefers the discomfort of an endotracheal tube to its natural airway.
In fact, one in six Kennel Club registered dogs today is an extreme brachycephalic - either a Frenchie, Bulldog or Pug - up from one in 50 ten years ago. Thousands more are being bred outside of the Kennel Club, feeding the obscene demand for flat-faced "cute".
It is, frankly, the biggest explosion in suffering the purebred dog world has seen in modern times.
Wednesday, 21 September 2016
Thanks a (five) million!
The PDE blog has this week just tipped over five million views.
I started it in November 2010 with the following message:
I should have got this blog up and running when Pedigree Dogs Exposed was first broadcast in August 2008. Guess I hoped there wouldn't be a need... And anyway, I fully expected to have moved on to pastures new by now...
It is now more than two years since PDE. I could never have guessed that the film's subject would have turned into such an ongoing passion. But passion it is, along with running Black Retriever X Rescue and living with my own dogs - trying not to count but there appears to be at least seven of 'em at the moment, plus two fosters.
Inherited disorders and welfare issues related to conformation affect millions of dogs all over the world and much of the problem is due to an antiquated breeding paradigm promoted by a kennel club system founded in England and exported to more than 100 countries. The price is paid by the dogs who suffer unnecessarily and by their owners seduced by a certain look unaware of the welfare cost that often comes with it.Almost six years and 600 posts on, the blog is more popular than ever - with well over a million hits this year already (due in no small part to the fuss over the German Shepherd at Crufts this year. The post showing the footage that the KC had edited out of the Channel 4 broadcast is now the most popular post of all time, including garnering 250,000 page views in a single day. (Links to all the most popular posts are in the sidebar on the right).
The blog is still most popular in the UK, followed by the US, Canada, Germany and Finland.
As I hope most people realise, the blog is a labour of love. I am not paid to write it and continue to refuse any offers to "monetise" it.
I write it because I hope and believe it is effective in drawing attention to specific issues and in galvanising those who are in a position to effect change.
Thanks to PDE (the films and this blog) there is a great deal more awareness of the problems and a large community of researchers, welfare bodies and vets focusing on them - absolutely key to drive through reforms.
Today, we have a Kennel Club that acknowledges that inbreeding is an issue and has given breeders tools to tackle it - something that was unthinkable before Pedigree Dogs Exposed when first-degree relative matings were considered acceptable and there was zero awareness that breeding profligately from one top-winning sire might be a bad thing to do.
Today, we have a Kennel Club that is much more aware of phenotypic excess and has taken steps to address them (and quite big steps recently in respect of the German Shepherd).
But we still don't have a Kennel Club that acts without outside pressure. Oh how I long for the day when the KC issues a release saying it is taking action on a particular breed because an internal review has revealed a specific problem. I know there are people at the Kennel Club who would like to be more proactive, but sadly they are often thwarted by those at the top, where the batten-down-the-hatches mode prevails.
I had a good laugh this morning at a BBC report highlighting vets' concerns about flat-faced (brachycephalic breeds). It contained this gem:
Sean Wensley, President of the British Veterinary Association (BVA) said: "Prospective owners need to consider that these dogs can suffer from a range of health problems, from eye ulcers to severe breathing difficulties."
"We strongly encourage people to choose a healthier breed or a crossbreed instead."
The BVA's warning has been backed by the PDSA, Royal Veterinary College, RSPCA and the Kennel Club.
Almost blogged it with the title: "KC urges puppy buyers to avoid Pugs, Frenchies and Bulldogs; choose a healthier breed or a crossbreed instead".
Of course it's just bad wording by the journalist who doesn't realise that the Kennel Club would never tell people to avoid a breed - or buy a crossbreed - on health grounds.
I hope the KC will find it too embarrassing to demand a change.
In fact, the BBC piece does go on to include this frustratingly-predictable (and somewhat garbled) deflection from Caroline Kisko:
Caroline Kisko, the Kennel Club secretary, said: "The breed standards were set many years ago. If you look back through history there are some dire things that went on, and undoubtedly we would accept all responsibility for that."
"But I would say that in the here-and-now, after all of the changes to the standards that were made in 2009, we would expect dogs to be far healthier if they are winning prizes at dogs shows."
Mrs Kisko said the problems with brachycephalic dogs were being perpetuated in the main by disreputable puppy farms.
She said: "If we continue to allow dogs to be brought in from central and eastern Europe where there is no concern for how these dogs are bred, it is inevitable that pet owners will end up with dogs they can't deal with."
"These are breeds which aren't hugely suited to pet homes. If you want a pet that will run around and chase a ball and so on, don't go out and buy any short-faced breed based on what celebrities are walking around with under their arm."And this is why I continue to give up time I don't really have to write the PDE blog. General journalists simply don't have the time or the interest to dig beyond the deflection and easy reassurances uttered by the Kennel Club.
• It is, of course, in the show-ring that you will find the very flattest of faces. In fact, show dogs' faces are flatter now than they ever have been as a direct result of show-ring selection and the pursuit of prize-winning rosettes. It is important to not be in any doubt about that.
• The KC continues to resist the introduction of minimum muzzle lengths into their standards.
• The standards still include demands that are counter to good health.
And then there's the small matter that all the recent surveys looking in detail at the health cost of having a flat face have been of of KC-registered dogs. These studies agree that at least half of all Pugs, Frenchies and Bulldogs struggle to breathe (and some have put it a great deal higher than that). Remember, too, that this is looking at just one consequence of being brachycephalic. There are many others, including eye, oral, dental, mating and whelping issues.
Bottom line... Kennel Club-registered dogs are still being bred and shown under the auspices of the Kennel Club in a way that perpetuates suffering for many breeds - and which, unless things change, will lead to their extinction.
At the end of the day, that's what this blog is about.
Monday, 12 September 2016
Ivan the terrible
If you cannot see the photos of Ivan below it's because they were embedded from Ivan's owner's Flickr album. M. Faucheron has now exercised his right to remove them at his end so they will no longer show.
If you missed them, they showed a "hyper-type" harlequin Great Dane with severe ectropion.
Just in case there is any doubt about how bad this dog's eyes are/were, here is the opinion of one of the UK's most senior veterinary ophthalmologists.
Just in case there is any doubt about how bad this dog's eyes are/were, here is the opinion of one of the UK's most senior veterinary ophthalmologists.
"There is marked lower eyelid ectropion and the dog would benefit from surgery (most simply as shortening of the lower lids). This dog will not be able to blink effectively and all kinds of rubbish collects in the ventral fornix, so chronic conjunctivitis is also a feature.
"Great Danes generally have rather poor eyelid anatomy and just look at all the loose skin elsewhere which gives a clue as to why they are so likely to have conformational eyelid abnormalities."
Et pour nos amis français (this dog's breeder is threatening to sue me for defamation - see comments section below):
"Il est marqué ectropion de la paupière inférieure et le chien bénéficieraient de la chirurgie (plus simplement comme le raccourcissement des paupières inférieures). Ce chien ne sera pas en mesure de clignoter efficacement et toutes sortes de collectes d'ordures dans le fornix ventral, la conjonctivite donc chronique est également une caractéristique.
"Les déformations des paupières graves sont celles associées avec soi-disant 'Diamond Eye', car cela provoque à la fois ectropion et entropion.
"Dogue Allemands ont en général assez pauvre anatomie de la paupière et il suffit de regarder toute la peau lâche ailleurs ce qui donne un indice quant à la raison pour laquelle ils sont si susceptibles d'avoir des anomalies de la paupière conformationnels."
(PS if the pix still show it is because you have visited before and your browser has cached them.)
The above picture is one of the first in a series of photographs by French Great Dane owner Arnaud Faucheron. The dog's name is Ivan de la Grisonniere (from a famous French show kennel) and the pictures below follow him from two months to about three years old.
That this dog is loved and has an amazing life in a beautiful part of the world shines through in these pictures - as does Ivan's spirit. But of course, it is overshadowed by how head-shakingly awful it is that anyone could think it was a good idea to breed a dog that looks like this.
The tragedy is that there are thousands of dogs like Ivan (and some even worse) being bred, shown and sold in Europe, where the "hyper-type" predominates.
Scroll down to the bottom of the page to see how you can help stop this.
That this dog is loved and has an amazing life in a beautiful part of the world shines through in these pictures - as does Ivan's spirit. But of course, it is overshadowed by how head-shakingly awful it is that anyone could think it was a good idea to breed a dog that looks like this.
The tragedy is that there are thousands of dogs like Ivan (and some even worse) being bred, shown and sold in Europe, where the "hyper-type" predominates.
Scroll down to the bottom of the page to see how you can help stop this.
There is a petition calling for urgent action on the Great Dane. You can find it here.
Please, please sign it - and share this post as widely as possible.
Sunday, 11 September 2016
UC Davis challenge: prove your Bulldog is healthy and we'll diversity-test for free
The Bulldog world has gone tonto following the publication last month of a study from a team at UC Davis which found that there was so little diversity in Bulldogs (or English Bulldogs as they're usually called outside of the UK) that there was little hope of being able to improve the breed.
On social media, the comment above is about par for the course. In case it needs to be said, it is also at best untrue and at worst defamatory. Professor Pedersen and the team at the UC Davis VGL Laboratory are leading researchers in the field. The paper was published in Canine Genetics and Epidemiology (a journal in fact financially supported by the Kennel Club ).
The health problems of the English bulldog have been well documented and start with conception, fetal development and parturition. Severe conformational changes have necessitated a high rate of artificial insemination and Caesarean sections and litter sizes tend to be small. The breed ranks second in congenital disease and associated puppy mortality, due mainly to birth defects such as flat chests with splayed legs; anasarca (water babies) and cleft palate. Although some English bulldogs enjoy reasonable health, their longevity is definitely affected by the degree of conformational change and inbreeding, which is reflected by lifespan estimates ranging from 3.2 to 11.3 years with a median of 8.4 years. Individuals requiring extensive veterinary care at a young age rarely live beyond 5–6 years of age, leading to a bimodal mortality curve for the breed.
The brachycephalic syndrome is a leading cause of ill- health and death in the breed. However, the syndrome is not caused by brachycephaly per se, as brachycephalic breeds such as the boxer do not suffer the syndrome to the same degree. The bulldog tongue is excessively large at the base, the palate is large and easily obstructed by the base of the tongue, the lower jaw is pushed forward (prognathous), and the nares are frequently stenotic and the trachea hypoplastic. This leads to loud panting during physical exercise, stridor during rest and slobbering; sleep apnea, hypercapnia and hypochloremia/hypomagnesemia; exercise intolerance, cyanosis and collapse; and choking fits manifested by gagging, retching, vomiting, aerophagia/ flatulence and aspiration pneumonia. The breathing difficulties of English bulldogs also make them very sensitive to overheating and heat stroke.
Chondrodysplasia, a heritable skeletal disorder that has been incorporated into the phenotype of many dog breeds, predisposes English bulldogs to skeletal disorders such as hip dysplasia, elbow dysplasia, luxating patella and shoulders, intervertebral disk disease, cruciate ligament rupture, hemivertebra, torsional pelvic deformity and problems with normal copulation and parturition. Prognathism predisposes to dental disease, while excessive folding of the skin, especially on the face, is associated with skin fold dermatitis, muzzle acne, folliculitis, furunculosis, and eye conditions such as entropion, ectropion, and eversion of the third eyelid. The cork-screw tail can result in tail fold dermatitis. Other heritable conditions that are related to loss of genetic diversity and inbreeding include cataract, various heart valve defects including pulmonic stenosis, hydrocephalus, cysteine urolithiasis, and hiatal hernias; immunologic disorders that include a propensity for severe demodectic mange indicative of immunodeficiency, allergies associated with atopic dermatitis and ear infections, and autoimmune diseases such as hypothyroidism; and cancers including glioblastoma, mast cell sarcoma and lymphoma. Although the bond and affection between English bulldogs and their owners is strong, the cost of treating health problems is often prohibitive and many of them end up in shelters or euthanized.
We believe that this paper accurately portrayed the current genetic and health problems of the breed, but we did mention that there was still phenotypic variability among bulldogs and that there are bulldogs that breathe freely, move freely, reproduce naturally, and that are free from skin and eye problems, allergies and other immunologic disorders. We did state, however, that it might be difficult to find a single dog that met all of these criteria.
Therefore, we are offering a challenge to bulldog breeders and owners from around the world to provide us with proof that their dog is a purebred (registered) English bulldog and to include a narrative and photographs/videos that supports their health status. Please email us at: email@example.com with this information and if we feel that this is indeed a dog that meets the criteria listed above, our Veterinary Genetics Laboratory will provide you free of cost with a DNA collection kit and from this a genetic profile of your dog that can be compared with the information provided in our genetic assessment paper.
We will also add genetic information from your dog to our genetic profile database for the English bulldog. Hopefully, this information will allow us to identify a genetic profile that is conducive to greater health. We may share your information online, but like the email alone any personal information regarding the owner, the dog and the breeder will be either redacted or changed. We do not make personal information public.
The UC Davis team says the impetus for the challenge came from an email from a Bulldog owner who sent them these pictures of their Bulldog 'Spike' (born and registered in India but now living in the UK).
Spike, said his owner, is as an active, healthy dog who loves to play. They admit he doesn't have the widest nostrils and that he snores a bit, but overall reckon he's fit as a fiddle. He's certainly lovely and lean - always good to see in Bulldogs. And I'd agree that Spike looks good for a Bulldog - although I don't think he'd be considered show material (he is not undershot enough and he doesn't have the correct 'layback').
You can read the whole of the UC Davis statement/challenge here.
Bottom line, I do have some sympathy with the Bulldog folk on this one. I do think there is a bit of wiggle room in the UC Davis paper.
Here's why:
The study drew its conclusions after studying DNA samples from 139 Bulldogs in total.
• 37 DNA samples were collected from dogs submitted for various diagnostic tests at UC Davis Veterinary Medical Teaching Hospitals (ranging from breathing, eye, skin and joint disorders to cancer)
• 102 DNA samples came from dogs submitted mainly to test for for coat colour or HUU (hyperuricosoria) (i.e. the tests done by breeders before breeding so presumed healthy). 87 were from the USA, six from Finland, three each from Canada and Austria and one each from Czechoslovakia, Hungary and Argentina.
Now that's a reasonable spread and the researchers found almost no discernible difference between them, hence their conclusions. But of course there were no dogs, for instance, from the breed's country of origin (UK). There has also been concern expressed by some Bulldog breeders that the coat-colour samples represent "colour" breeders who they think are more likely to inbreed (ergo less diverse) and thus are not representative of "responsible" breeders.
Of course, there were dogs being tested for HUU too (a sign of a "responsible" breeder) too and I would be surprised if colour-bred dogs are more inbred that your average show-bred Bulldog. But it's fair enough to question it.
So Bulldog owners... please do rise to the challenge!
I also think it would be a great idea for Bulldog owners in general to get together to send in more DNA samples - and not least because the current price of just $50 a dog (around £37) per dog is a bargain.
If nothing else, wouldn't proving the UC Davis team wrong be worth it? Even if they're right and you're wrong, you'd still get useful diversity info about your dog - a tool that many breeders in other breeds are now using to breed better dogs.
More info here...
Saturday, 10 September 2016
Kennel Club identifies "priority" breeds for new conservations plans
The KC has finally released more information about its new breed health and conservation plans (BHCPs).
The plans will, it claims, take a "holistic" approach, embracing genetic issues, conformation concerns and population genetics.
As revealed in today's Dog World (see here):
"To help determine the impact and importance of the health concerns in each breed, a number of evidence-based criteria will be used. Each health concern identified will be assessed and prioritised, based on welfare implications, proportion of the breed affected and likelihood of the concern getting worse in the future. The bespoke nature of these breed-specific health plans will include monitoring and review, to ensure they are up-to-date and remain relevant."
The KC has identified the following as its "priority" breeds for 2017:
Basset Hound
Cavalier King Charles Spaniel
Chow Chow
Clumber Spaniel
Dogue de Bordeaux
English Setter
French Bulldog
German Shepherd Dog
Neapolitan Mastiff
St Bernard
This comprises all 11 Category 3 breeds (defined as "Breeds where some dogs have visible conditions or exaggerations that can cause pain or discomfort") and six others that regularly feature on this blog.
I am, of course, delighted that the Kennel Club has seen fit to take my advice regarding the introduction of conservation plans - as I proposed in this post just over five years ago.
The devil, however, will be in the detail....and also key will be how influential the breed health co-ordinators will be allowed to be. As the KC says:
"Breed Health co-ordinators will continue to be central collaborators in the identification of health concerns and risks."
Unfortunately, many reading this will know that while there are some decent health reps others are abysmal, essentially seeing their role as defenders of the status quo.
Most of the BHCs for the above breeds would fiercely oppose any meaningful changes to the breed standard or any proposals to outcross (outside of the breed) to inject some much-needed genetic diversity - with one or two exceptions perhaps. Three of these breeds have seen outcrosses - the Clumber to a Cocker (the descendants of which are now being shown in the UK); the Bloodhound and Otterhound to non-registered working dogs. All have caused a fuss, though.
The KC, however, maintains that the project will involve collaboration across a broad spectrum of stakeholders including breed clubs and the veterinary and research community so hopefully it won't be possible for an in-denial BHC to have too much influence.
In fact, the Dog World article includes this:
The KC has asked for any health information you have collected through health surveys or health schemes. This can be e-mailed to firstname.lastname@example.com.
I am pretty sure that's aimed at the Breed Health Co-Ordinators, but I would urge anyone with useful observations/research about genetic, conformation or diversity concerns in any breed (not just the ones listed above) to take this opportunity to contact the Kennel Club, with "BHCP - [breed]" in the subject line. That should ensure they are included when the discussions start in earnest.
It would also be a good idea to forward relevant papers as I am astonished at how often breeders appear to have never heard of key health surveys/published research on their breed.
That address again: firstname.lastname@example.com
Please feel free to copy/blind-copy in on any emails you send to the Kennel Club. I am very happy to act as a back-up repository of breed-specific information - in complete confidence of course unless mutually agreed otherwise.
Please feel free to copy/blind-copy in on any emails you send to the Kennel Club. I am very happy to act as a back-up repository of breed-specific information - in complete confidence of course unless mutually agreed otherwise.
Friday, 9 September 2016
Cavalier challenge exposes fundamental flaws
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Dog World columnist Sheila Atter tackles health-testing in this week's issue (see here), broadly supporting cavalier campaigners' demand for an official heart-testing scheme for the breed.
She writes:
Many of us have been urging the formalisation of heart testing for many years. There is already a panel of recognised cardiologists and several breed clubs make use of their services, so it really can't be too difficult to regularise this can it?
But Sheila has infuriated the campaigners by her lack of enthusiasm for a mandatory testing for the breed's other big problem: syringomyelia:
The problem with syringomyelia is far more complicated, not least because the geneticists can't really come up with an accurate explanation of the mode of inheritance of the condition. There are many breeders who have been scanning for years, and still cannot predict with 100 per cent confidence whether their pups will be SM free.
Instead of haranguing all Cavalier breeders – and in particular those who show their dogs – critics such as Emma Milne would do more good by throwing their support behind those breeders who are health testing, nearly always the same it's show breeders who get all the flak. If the general public were continually urged to steer clear of unregistered puppies, virtually none of which come from health tested parents, some progress might be made.
It has prompted a sharp response from cavalier owner and campaigner Charlotte Mackaness, who has posted in the Comments section:
But the challenge raises a really key issue. We need to make it a whole heap easier for consumers to buy better dogs. Currently, we are asking them to do way too much work - ridiculous in an age where we can order a fridge off the internet with the full expectation that it will work and that we can secure redress if it doesn't.
We've got to stop being disappointed with consumers for not doing the research and opting for instant fixes like the one offered by the peddlers of the puppy in the pic above.
My suggestions:
• a centralised resource, offered ideally by the Kennel Club, where puppy buyers can:
- review best practice for that breed
- see the compliance to this best practice for every litter advertised on the KC's website
• every puppy to be sold with a 2-yr warranty (extendible at the buyer's expense) against preventible genetic defects. Plain and simple and an added value something every consumer would understand.
• speed up the puppy-buying process so that people are not being asked to wait for weeks for a new dog.
• customer reviews: we do this for absolutely everything these days: hotels; sellers on eBay; goods on Amazon.
I read with alarm the suggestion that testing for Syringomyelia was somehow less pressing because of the condition's complex inheritance. Just like MVD, SM is polygenic with no simple test that can give a guarantee puppies will be unaffected but studies have shown that their chances are greater if their parents are clear. Surely this makes scanning worthwhile because doing something to improve the odds is better than doing nothing at all and simply hoping for the best? Playing that kind of Russian roulette is morally indefensible.
In my book, any Cavalier breeder who truly has the breed's future and well-being at heart is scanning and putting the results through the official scheme so, even if for no other reason, researchers have more information with which to learn about SM and the KC may stand some chance of establishing Estimated Breeding Values.Ms Mackaness then goes on to tackle Sheila's assertion that the consumer must take some of the blame for buying puppies from untested parents:
And she issues this challenge:
Undoubtedly the consumer wields a great deal of power but finding a puppy from properly health tested parents can be a difficult task for even the best-informed and patient of puppy buyers. While many breeders and breed clubs talk a good game when it comes to health, my experience is that very, very few walk the walk.
I wonder whether you could find 10 litters registered within the last 12 months bred following the MVD protocol (heart tested clear at 30 months or older with parents aged at least five and heart clear), eye tested, DNA tested and with BOTH parents complying with the MRI breeding guidelines?
I appreciate this might be quite a task given the absence of an official heart scheme and so few MRI scans going through the official CM/SM scheme but it might also lend an appreciation of the barriers and difficulties facing puppy buyers. Perhaps starting with Cavalier Club committee members might save some time as it would be sensible to assume that such people follow the highest possible standards when breeding.Well, I'll happily save Ms Atter some time in telling her that it is impossible - Cavalier breeders at the very highest level are simply not complying - in no small part because they don't have to.
But the challenge raises a really key issue. We need to make it a whole heap easier for consumers to buy better dogs. Currently, we are asking them to do way too much work - ridiculous in an age where we can order a fridge off the internet with the full expectation that it will work and that we can secure redress if it doesn't.
We've got to stop being disappointed with consumers for not doing the research and opting for instant fixes like the one offered by the peddlers of the puppy in the pic above.
My suggestions:
• a centralised resource, offered ideally by the Kennel Club, where puppy buyers can:
- review best practice for that breed
- see the compliance to this best practice for every litter advertised on the KC's website
• every puppy to be sold with a 2-yr warranty (extendible at the buyer's expense) against preventible genetic defects. Plain and simple and an added value something every consumer would understand.
• speed up the puppy-buying process so that people are not being asked to wait for weeks for a new dog.
• customer reviews: we do this for absolutely everything these days: hotels; sellers on eBay; goods on Amazon.
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