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Why Kelo is Not Good News for Local Planners and Developers
Daniel H. Cole
Indiana University Maurer School of Law; Indiana University School of Public and Environmental Affairs; Indiana University Bloomington - Workshop in Political Theory and Policy Analysis
Georgia State University Law Review, Forthcoming
When the Supreme Court announced its 2005 decision in Kelo v. City of New London, few legal scholars were surprised at the outcome, which was premised on precedents extending back to the middle of the 19th century. Legal scholars were surprised, however, by the intense political reaction to Kelo (fueled substantially by Justice O'Connor's hyperbolic dissent), as property-rights advocates, legislators (at all levels of government), and media pundits assailed the ruling as a death knell for private property rights in America.
Kelo's combination of relative legal insignificance and high political salience makes it an interesting case study in cross-institutional dynamics, i.e., the study of how the combination (and recombination) of political, legal, economic, and social forces determine the content of our laws. In this case, the Supreme Court's legal ruling in Kelo generated a political controversy, which is leading to legislative changes in the law. Those legislative changes, in turn, will affect future court decisions.
The primary purpose of this article is to explain the aftermath of Kelo as a socio-legal phenomenon, which is every bit as important as (perhaps more important than) the Supreme Court's ruling in the case. By paying close attention to the political and legislative aftermath of Kelo, we can understand why the Supreme Court's decision is not good news for local planners and developers, who are finding it significantly more difficult to engage in urban (re)development throughout the United States. By contrast, the plaintiffs who lost the Kelo battle, may have won the war to keep their homes.
This article also has a secondary purpose, which is the place Kelo and its political reception in a larger comparative-institutional context. That context (which I develop more fully in another article, Political Institutions, Private Property and Judicial Review: A Comparative Institutional Analysis, forthcoming in 2007 in the Supreme Court Economic Review) examines how political bodies, as well as courts, substantially protect private property rights. Kelo's aftermath, along with other evidence from the United Kingdom and the several U.S. states, supports the proposition that, even in the absence of constitutional protections assiduously enforced protected by judges, the institution of private property would be substantially protected.
Number of Pages in PDF File: 48
Keywords: Law, property, takings, eminent domain, Kelo, United States, United Kingdom, legislation, politics, public choice
JEL Classification: D23, D72, G32, H42, H72, H82, K11, Q15, R3, R14
Date posted: February 5, 2006
Suggested Citation
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. . .c h a s m. . .
He saw a couple in front of the Hachiko statue. The boy had his arms around her waist, her back to him. She was looking desperately, with devastating hope in her eyes, up at the statue, wishing, praying, willing.
He came over to them, walking in front of the girl. She couldn't see him, of course. No one could. But he felt a dangerous need for her to look at him, to see him. He just did. He didn't know why. It scared the living hell out of him.
He found himself reaching out to touch her cheek. If he was alive, he never would have dared to touch a girl this way. But right now, it felt completely natural. He didn't feel out of place at all as his palm cupped her face.
She gasped, flinching backward. The guy's arms tightened around her.
"Babe, what's wrong?" He looked worried.
She shook her head quickly, searching with her eyes over him, over the air. "Nothing, nothing, just thought got a chill." She smiled up at him. "Hey, can you do me a favor?"
He relaxed. "O' course."
"Get me a hot dog? Please?" She gave him a charming smile.
Neku's eyes widened.
The guy sighed. "You're gonna make me walk that far?"
He looked down at the confirming smile on her face.
He huffed. "Right. Be right back, then."
"Thanks bunches!" She waved at him. Once he was out of sight, she turned solemn.
Hesitantly, she reached her hand out toward the direction that he touched her. She didn't say anything. He stared at her hand. He looked back up to her face, to her eyes.
They weren't different. Not at all. He took in a breath and stretched out his hand.
He felt her warmth. He curled his fingers around her hand, only to have it seep through.
He watched her blink, ready for her to pull away. But she didn't.
She stuttered rapidly. "N-Neku…I-is that-is that really-," she didn't finish.
She fished out Mr. Mew. He could've sworn his heart stopped.
She opened her mouth, but closed it. She knew he knew.
He couldn't do anything about it, and it almost killed him. If she only knew how close he was to winning…
He reached out his hand again, touching her cheek, slowly caressing her new—old—face.
It made him feel odder than odd, but he could never be extremely sure if he would ever see her again. In case he-
She put her hand on her cheek, her hand seeping perfectly with his.
And that's how they stayed, her looking directly through his soul, even if she didn't realize. He memorized every curve of her face, every strand of hair, every freckle.
And he hoped that this one, long touch would tell her everything that he carried in his heart, that he begrudgingly admitted when he knew it was her.
And when he felt the presence of that guy nearing closer and closer, he edged, he leaned, he fell.
She fell back.
When it was over, he watched her take the food with a fake smile, and one more glance his way.
He felt his heart tear away and follow her retreating back. He couldn't help but fall to his knees from the explosion in his chest.
And from that moment on, he knew there wasn't a chance in hell that he would lose.
He'd be damned if he let her walk away from him again.
a/n: I think I wrote this sometime last year. But I had to post it, because NekuxShiki is cute. :) And I thought a lost moment between them was deserved, throughout everything they had to go through.
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"It is better that one man should die, rather than the people." This was the prophecy from the high priest Caiaphas, as quoted by the John in the 18th chapter of the fourth Gospel. And it is Caiaphas who questions Jesus about His divinity in Matthew 26:57-64, before turning Him over to Pontius Pilate to be crucified. Those who had seized Jesus led Him away to Caiaphas, the high priest, where the scribes and the elders were gathered together. But Peter was following Him at a distance as f … [Read more...]
Scientists Discover Remains of the High Priest Caiaphas
August 4, 2012 by Leave a Comment


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Groupwork 48" Table
by Turnstone
At A Glance:
Perfect for your own personal workspace or collaborative meeting place, the 48" wide Groupwork Desk provides smart design, good value and the solid performance you'll come to expect from Steelcase office furniture. Choose the depth and finish that works best for your space.
What's To Like:
If you really love straight lines and simplicity: this is your table. No clutter, no distracting "design features," just a sturdy table. The caster options and flip-top option make it a great choice for a training room or constantly-changing workplace.
What's Not to Like:
Let's see ... the Groupwork Table's legs will be difficult to attach if you don't have a drill. You can just use a screwdriver, if you have some serious oomph, but it'll be a task. (Note: we can't believe spellcheck recognized "oomph" as a word.)
The Bottom Line:
With a wide range of laminate choices, optional casters, and sturdy construction, the Groupwork Table is a great work table choice for offices, both home and workplace.
- 1-1/8" thick desktop with durable, low-pressure laminate finish
- Choose from 24" and 30" depths
- Also available are the Groupwork 60" wide desk and the 72" wide desk
- 3mm radius profiled edge banding for a smooth, sophisticated look
- Choose from standard T-Legs or optional post legs or flip-top caster legs
- If chosen, flip-top legs allow you to flip the desktop up for easy storage
- Casters are an option for any of the leg choices, to give you extra mobility
- Leg Height (without casters) is 27" h
- Optional modesty panel for a more private work environment
The Steelcase Groupwork Table is also known by the following manufacturer item number: TS4TLR2448.
Materials & Measurements
Low-pressure laminate tabletop and edge banding. Powder-coated steel legs.
Overall Dimensions:
27.375" h x 48" w x 24" or 30" d (depending on selection)
Top Dimensions:
48" w x 24" or 30" d (depending on selection) x 1.125" thick
Modesty Panel Dimensions:
37.625" w x 9" h
About The Manufacturer
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Standard Curbside: Free
Standard ground shipping includes delivery by FedEx or UPS to your door or main lobby. Once shipped, items generally arrive within 2-5 business days. Simple, fast and easy service.
Inside Delivery: $99.00 per item
Inside delivery is a cost efficient way to have large or fragile items delivered to your room of choice. When your order reaches the local station in your area, the delivery agent will call to schedule a four hour delivery appointment. Caveat: If you need debris removal or light assembly (30 min max), you may want to consider our White Glove service.
Premium Inside Delivery: $149.00 per item
Premium Inside Delivery is our most comprehensive delivery service option. This service includes a four-hour delivery appointment, placement inside your room of choice (two flights of stairs max), unpacking, set up (up to 30 minutes without tools), and debris removal. If you want a no hassle delivery experience, this is your best option.
Assembly time of over 30 minutes and room placement over two flights of stairs incurs additional shipping charges. Please call 888-467-6278 for more information and a customized quote.
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Product Q&A
Turnstone Groupwork Desks are backed by Steelcase's limited lifetime warranty.


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AWS Backup And Recovery
These thoughts were running through my head at Cloud Connect when I ran across a second bit of information that strikes me as addressing that latter topic in a different way. SunGard, which now has six cloud data centers for providing high availability production environments, is about to sign a pact with Amazon Web Services to provide backup and recovery services to customers in Amazon data centers.
That is, Amazon seems aware--as well it should be after its U.S. East data center outage last April--that customers need a simple option for implementing backup in a geographically separate facility. Amazon so far has offered it in different availability zones within an Amazon data center or complex of centers, but not in a geographically separate part of the country. During the 2011 Easter weekend freeze-up, one of the ways customers avoided being hurt was to shift their virtual machines out of U.S. East. Not everyone had provided for such a maneuver, and in the crunch, they learned the hard way that one availability zone wasn't as isolated from another as they had assumed.
Amazon, for its part, has caught the scent of what those telcos have in mind as they maneuver behind its pioneering back. Amazon hasn't linked its own data centers so a workload in one can be backed up in another. But it also wants it to be easy to implement disaster recovery and data recovery. Linking to a SunGard center in Ireland or the United Kingdom would be a natural for Amazon's Dublin, Ireland, facility. Likewise, U.S. East isn't far from Philadelphia, where SunGard has another center. Better to provide an ease of linking itself, rather than leave it to those telco suppliers. SunGard will have more than just backup services available. An announcement is coming soon.
Cisco Tackles Cloud Security
On another front, Lew Tucker, CTO of cloud computing at Cisco Systems, gave a revealing talk in his 15-minute slot in the rapid-fire Cloud Connect keynotes Tuesday, but it was just complicated enough for perhaps some its import to be missed. Enterprises have progressed smartly with both storage and server virtualization, while the network, hardwired into its devices, has tended to lag behind.
Tucker, who was lead on cloud computing at Sun Microsystems before joining Cisco, is in an excellent position to say what's happening on that front. To realize the full benefit of virtualized resources, the network needs to be subdivided into a series of isolated subnets, with one or more subnets serving a single virtual data center, he said in his keynote.
That would mean an additional guarantee of privacy and security for the user or users of a virtual data center, allowing them to do in the cloud many of the things they do in their private enterprise data center. This can already be done, of course, by establishing a VLAN for each user that needs to tunnel into the cloud center, but that's an expensive and wasteful alternative. Only so many VLANs can be created per data center--the max is somewhere around 2,000, a finite number compared to the demands that can be placed on a modern data center.
Cisco has been working on the problem, said Tucker in an interview after his speech, and its answer takes the form of a contribution to the OpenStack open source code project--Quantum. Developers today seek a cloud service by generating a call to its IP address. They should be able to include a description of networking requirements in an application, and have a software receiving agent, with access to services, examine the incoming workload and specify the service they want. It would issue orders for services through the cloud API, and services would be activated from there.


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Iron ore has soared on the back of Donald Trump's US$1trn infrastructure promise and a favourable Goldman Sachs report citing further supply shortages in China.
Zak Mir, technical analyst at Tip TV, believes the price spike to US$75 per tonne that followed Trump's US presidential victory has yet to run its course.
Indeed, the bulk metal may be heading to as high as US$90 per tonne in the short-term he suggests.
Story by ProactiveInvestors


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pinMode(ledPin, OUTPUT); // sets the pin as outputanalogWrite(ledPin, 75);
Even in very simple sketches using Arduino Duemilianove (atmega 328), whenever I use Wire.begin AND lcd.begin I get bizarre erroneous results both on the serial monitor and on the LCD.
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The 'yes' vote has declined to 45 per cent from 48 per cent a week ago and the 'no' vote has risen to 29 per cent from 27 per cent, according to the Gallup poll published in Berlingske Tidende. However, last week bookmakers stopped taking bets on the referendum outcome, so convinced are they that the result will be support for the treaty.
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If ever there was a sport that combined seasonal drinking with inclement weather conditions, it has to be table-sledging. This new sport was apparently dreamed up by a group of drunk students who became stuck in deep snow in a cabin in the Austrian Alps and decided that their only way out was to turn a table upside down and bomb down the slopes on it. Legend has it that when they got to the bottom, they turned it back over and carried on drinking. Now the Austrian ski resort of Kühtai has just staged the inaugural three-day Table-Sledging Championships. It's not known if the Bolton Mountain Rescue team are intending to enter the event next year but one of their members, Matthew Hailwood, had to be rescued by the North West Air Ambulance on Boxing Day after they had spent the day sledging on Rivington Pike. He sustained serious bruising and had been carried to the bottom of the hill on a stretcher, which came in handy since it was the stretcher that they had been using as a sledge.
Speed in miles per hour achieved by Paul Stender's portable toilet at a race track in Indianapolis, Indiana. The outhouse is propelled by a 1,000 horse power Boeing jet engine and produces 30ft of flames in its wake – though these are not produced by natural gases. So if you ever really need to go...
Eve implicated in fall of man again
It's New Year's Eve with a difference in Turlock, California. Like so many others before her, the model Amazon Eve found it a real struggle to land the acting roles she craved. But in one crucial respect she is not like all the others: she is 6ft 8in tall. Fed up with being cast as a monster or an alien, she has turned to a new venture: wrestling small men. The 31-year-old, whose real name is Erika Ervin, will toss you around for $400 (£260) an hour – though you have to be less than 5ft 8in. In Fresno, California, the leader of the Buchanan High School Bears wrestling team faces charges of sexual battery after using a traditional maneouvre called the "butt-drag". Competitors grab the buttocks of a fighter to gain leverage but Preston Hill, 17, stuck a finger up his opponent's anus in the process. Apparently these things happen in the ring from time to time.
Good week
Tristan Miller, 33, from Melbourne becomes the first man to run 52 marathons in 52 weeks – taking in 42 countries on all seven continents... Ping-pong players from outside China will be allowed to enrol on the four-year course at the new Academy of Table Tennis in Shanghai... Bend It Like Beckham becomes the first Western-made film to be shown on North Korean television in recognition of 10 years of diplomatic relations between the country and the UK.
Bad week
Brett Favre, the veteran Minnesota Vikings quarterback, is fined $50,000 (£32,000) for not co-operating with an NFL inquiry into allegations that he sent lewd pictures of himself to the New York Jets match-day host Jenn Sterger... Mario Ferri, Italian serial pitch invader, is arrested in the hold of a cruise ship after announcing on Facebook that he was fleeing trial in Abu Dhabi for running on during the Club World Cup final... Dancing On Ice, preparations for which were disrupted in Shepperton, Surrey, by the local council commandeering ice-treating chemicals.
Tee but no sympathy. Is this a fair way?
Great news for all rubbish golfers out there. The New York Court of Appeals has thrown out a personal injury lawsuit stretching back to 2002 and ruled that a player cannot expect to be warned with a shout of "fore!" every time another player hits an errant shot. Dr Anoop Kapoor was said not to have committed intentional or reckless conduct when he struck Dr Azad Anand on a course in Long Island, blinding him in one eye. Meanwhile Rebecca Dunn is suing the NFL's Cincinnati Bengals, their Paul Brown stadium and a beer vendor for continuing to sell beer to two "noticeably intoxicated" fans who fell on her at a game. She broke a finger and received a gash to her nose — injuries which have so far incurred medical expenses of $20,000 – and is also seeking compensation for the cost of staying in a hotel because she could not retrieve her car after being treated, and for a pair of $700 sunglasses that were broken in the mêlée. The shits have really hit the fan.
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Multiple plumes on Io
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Meet Nathalie Yafet
Nathalie and her husband, Steven, have lived in Hillside for 24 years. A past board president and vice-president, she has served on every committee at some point in her 15 years on the board and is the current chair of Education and Negotiations.
Nathalie is on the board of directors for the NJ School Boards Association and the Union County Educational Services Commission and is an NJSBA certificated board member. She is past-president of the WOK PTA.
She is convinced that keeping politics out has helped turn our schools around.
Nathalie has a bachelor's degree in music from the University of Wisconsin.


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Director Responds to Earl Sweatshirt's Comments on Taylor Swift's 'Shake It Off' Video
Earl Sweatshirt is one of those people who brand Taylor Swift's brand new "Shake It Off" music video racist. Earlier this week, the Odd Future Wolf Gang Kill Them All rapper said on Twitter that he hadn't seen the visuals but he knew it was "inherently offensive and ultimately harmful."
Mark Romanek, who directed the clip, has now responded to the criticism and defended his work. "He stated clearly that he hadn't seen the video and didn't even intend to watch it. So, respectfully, that sort of invalidates his observations from the get-go. And it's this one uninformed tweet that got reported on and rehashed, which started this whole 'controversy,' " he told Vulture.
"We simply choose styles of dance that we thought would be popular and amusing and cast the best dancers that were presented to us without much regard to race or ethnicity," he continued. "If you look at it carefully, it's a massively inclusive piece. It's very, very innocently and positively intentioned. And - let's remember - it's a satirical piece. It's playing with a whole range of music video tropes and cliches and stereotypes."
The helmer, who has previously worked with the likes of Johnny Cash, Jay-Z and Nine Inch Nails, went on saying that Swift came up with the idea of "Shake It Off" video. "She wanted to make a sort of paean to the awkward ones, the 'uncool' kids that are actually cooler than the 'cool' kids," he explained.
Romanek added, "I think, if Earl Sweatshirt was open-minded enough to take the four minutes to watch it, he might see what the larger, humanistic, and utterly color-blind message was intended to be."
More Taylor Swift News
- Blac Chyna Celebrates 40-Pound Weight Loss by Posing Nude in Bed
- Kristen Stewart In Talks for Fox's Thriller 'Underwater'
- 'The Predator' Reboot Adds 'Chuck' Alum Yvonne Strahovski
- Nick Cannon Introduces Newborn Baby Boy Golden 'Sagon'
- Jamie Chung to Play Blink in FOX's 'X-Men' Pilot
- Racist Men Charged for Hurling N-Word at Jamie Foxx
- Cate Blanchett Turns Into a Drag Queen for Charity
- See Mindy Transforming Into a Handsome White Man on 'The Mindy Project'


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Terrence Malick Speaks
The first promising wide release of the year is arriving in just over a week, as Steven Soderbergh debuts what is purportedly said to be his final theatrical film, for at least some time. While those that have seen the pharmaceutical drug thriller Side Effects have warned fans to go in knowing as little as possible, Open Road has unveiled a new batch of clips, following the first one last week.
In case you were on the fence, or simply want to see Soderbergh directing his last theatrical film for some time in over 8 minutes of behind-the-scene footage, this should do the trick. Check them all out below for the film starring Rooney Mara, Jude Law, Channing Tatum and Catherine Zeta-Jones, and one one can also read our mostly spoiler-free review, in which we adored the first hour, but were let down by the rest.
Side Effects hits theaters on February 8th.
Since any New York City cinephile has a nearly suffocating wealth of theatrical options, we figured it'd be best to compile some of the more worthwhile repertory showings into one handy list. Displayed below are a few of the city's most reliable theaters and links to screenings of their weekend offerings — films you're not […]
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With Instructables you can share what you make with the world, and tap into an ever-growing community of creative experts.
I needed to clean the chimney of a new/old house I just moved into. I looked online and found a couple videos of professional chimney sweeps using a ...
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Expert needed to create a Bigcommerce website with webgility integration
This project received 50 bids from talented freelancers with an average bid price of $5119 USD.Get free quotes for a project like this
Project BudgetN/A
Total Bids50
Project Description
This is a summary of our requirements. The link provided gives more information. We have tried to be as explicit as possible in writing the requirements.
Google doc requirements link: [url removed, login to view]
We are building a store that will be selling assorted goods (like [url removed, login to view] or [url removed, login to view]). We will start by selling grocery and personal care products. In this initial release, customers will be able to buy products online and pick them up at the warehouse. In a later release, we will ship products to our customers. We want you to configure a Bigcommerce template (or create a new template) that has responsive design (I see that some Bigcommerce templates already have this). We want the website to be structured like [url removed, login to view] or walmart.com. This template should match the colors in our logo. We will need integration with Quickbooks (webgility integration). In addition to placing an order and paying online, customers will also need to be able to place an order online, but pay in the store. This store will need the typical things such as order management and inventory management (provided by Bigcommerce).
At delivery time we need a demo of all developed functionality (including workflows like order management) and where in Bigcommerce is the configuration for that specific piece of functionality
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Is Techtuch Ur Life incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog INDIA provides information regarding Techtuch Ur Life. Techtuch Ur Life provides Home Entertainment services. Contact them on +91 9990 638 978 or by visiting them on their website http://www.techtuchurlife.com.
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There are hundreds of nationally recognized Professional qualifications & training courses from the worlds leading education providers. Course objectives should lead to teaching methods and student interest.
If you enjoy and are good at playing and making music, a master's program in music could be for you. In a music program, you will learn how to compose, write and play music. This will improve your musical talent and propel you further in your career, in music.
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Research Topics
Genomes and Genes
lysyl hydroxylase
Gene Symbol: lysyl hydroxylase
Description: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Alias: EDS6, LH1, LLH, PLOD, lysine hydroxylase, lysyl hydroxlase 1, procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications267 found, 100 shown here
- Identification of arginine-700 as the residue that binds the C-5 carboxyl group of 2-oxoglutarate in human lysyl hydroxylase 1K Passoja
Biocenter and Department of Medical Biochemistry, University of Oulu, Finland
FEBS Lett 434:145-8. 1998b>Lysyl hydroxylase catalyzes the formation of hydroxylysine in collagens by a reaction that involves oxidative decarboxylation of 2-oxoglutarate...
- Deletion of cysteine 369 in lysyl hydroxylase 1 eliminates enzyme activity and causes Ehlers-Danlos syndrome type VIH N Yeowell
Division of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
Matrix Biol 19:37-46. 2000This study describes the relative contribution of the 10 cysteine residues in lysyl hydroxylase 1 (LH1) to enzyme activity...
- Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activityKati Rautavuoma
Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
J Biol Chem 277:23084-91. 2002b>Lysyl hydroxylase (LH) catalyzes the formation of hydroxylysine in collagens; three human isoenzymes have been cloned so far...
- Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblastsMitsuru Saito
Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan
J Bone Miner Res 18:1695-705. 2003..We found that altered gravitational load affected the post-translational modification of collagen, particularly the collagen maturation pathway, through altered expression of enzymes involved in cross-link formation...
- An Ehlers-Danlos syndrome type VIA patient with cystic malformations of the meningesHeather N Yeowell
Div of Dermatology, Duke Univ Medical Centre, Durham, NC, USA
Eur J Dermatol 15:353-8. 2005..9 kb in the lysyl hydroxylase 1 (LH1) gene that is the cause of severely decreased levels of LH activity in her skin fibroblasts...
- Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?J Brinckmann
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Matrix Biol 24:459-68. 2005..In the present study, we analyzed the cross-link pattern and the gene expression of lysyl hydroxylase 2 (LH2) in the skin of SSc...
- A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestationsTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 152:1333-46. 2010..and skeletal features, overlapping with the kyphoscoliosis type Ehlers-Danlos syndrome (EDS) but without lysyl hydroxylase deficiency [Kosho et al. (2005) Am J Med Genet Part A 138A:282-287]...
- Differential diagnosis of muscular hypotonia in infants: the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VI)Uluc Yis
Division of Child Neurology, Dokuz Eylul University School of Medicine, Department of Pediatrics, 35340 Izmir, Turkey
Neuromuscul Disord 18:210-4. 2008..Biochemically, it is characterized by a deficiency of collagen lysyl hydroxylase (EC 22.214.171.124) due to mutations in PLOD1...
- Interstitial collagen synthesis and processing in human amnion: a property of the mesenchymal cellsM L Casey
Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas, Southwestern Medical Center, Dallas 75235, USA
Biol Reprod 55:1253-60. 1996..2(I), and alpha 1(III) subunit mRNAs and the specific activities of the enzymes prolyl 4-hydroxylase and lysyl hydroxylase were greatest in human amnion tissue early in gestation, decreasing rather abruptly after 12-14 wk gestation ..
- Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylationL C Walker
Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Med Genet A 131:155-62. 2004..diagnosis of Ehlers-Danlos syndrome type VI (EDS VI; kyphoscoliosis type), have significantly decreased lysyl hydroxylase (LH) activity due to mutations in the LH1 gene (classified as EDS VIA: OMIM no. 225400)...
- Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome--an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13Cecilia Giunta
Division of Metabolism and Molecular Pediatrics, University Children s Hospital, CH 8032 Zurich, Switzerland
Am J Hum Genet 82:1290-305. 2008..2 in controls. Lysyl and prolyl residues of collagens were underhydroxylated despite normal lysyl hydroxylase and prolyl 4-hydroxylase activities; underhydroxylation was a generalized process as shown by mass ..
- Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequencesKati Takaluoma
Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014, Oulu, Finland
Matrix Biol 26:396-403. 2007b>Lysyl hydroxylase (LH), with three isoenzymes in vertebrates, catalyzes the formation of hydroxylysine by acting on -X-Lys-Gly- triplets in the collagenous domains of proteins of the collagen superfamily and also in -X-Lys-Ala- or -X-Lys-..
- Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxonA Samimi
Pulmonary Critical Care Medicine, University of California, Davis, California 95616, USA
Toxicol Appl Pharmacol 176:181-6. 2001Direct inhibition of lysyl hydroxylase by malathion and malaoxon was observed in an in vitro enzyme assay with recombinant lysyl hydroxylase expressed via a baculoviral system...
- Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null miceKati Rautavuoma
Collagen Research Unit and Department of Medical Biochemistry and Molecular Biology, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland
Proc Natl Acad Sci U S A 101:14120-5. 2004..We generated mice with targeted inactivation of the gene for one of the three lysyl hydroxylase isoenzymes, LH3. The null embryos developed seemingly normally until embryonic day 8...
- Lysyl hydroxylase 3 (LH3) modifies proteins in the extracellular space, a novel mechanism for matrix remodelingAntti M Salo
Department of Biochemistry and Biocenter Oulu, University of Oulu, Oulu, Finland
J Cell Physiol 207:644-53. 2006b>Lysyl hydroxylase 3 (LH3), the multifunctional enzyme associated with collagen biosynthesis that possesses lysyl hydroxylase and collagen glycosyltransferase activities, has been characterized in the extracellular space in this study...
- Coenzyme A stimulates collagen production in cultured fibroblasts; possible mechanisms in enzymatic and gene expressionK Mio
Life Science Research Center, Lion Corporation, Odawara, Kanagawa, Japan
Arch Dermatol Res 293:522-31. 2001..hand, coenzyme A did not stimulate the activity nor the gene expression of two other processing enzymes: lysyl hydroxylase, which provides the sites for glycosylation and crosslinking between collagen peptides, and lysyl oxidase, a ..
- Procollagen synthesis is increased in hypothyroid rat ovary by a parallel and compensatory pathwaySamir Kumar Saha
Molecular Endocrinology Laboratory, Indian Institute of Chemical Biology, Kolkata, India
Cell Physiol Biochem 19:313-22. 2007..Down regulation of lysyl hydroxylase in hypothyroid condition results less collagen formation...
- Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymesJanice A Vranka
Research Department, Shriners Hospital for Children, Portland, Oregon 97239, USA
J Biol Chem 279:23615-21. 2004..3-hydroxylases, which share the conserved residues present in the active site of prolyl 4-hydroxylase and lysyl hydroxylase. P3H1 is the chick homologue of mammalian leprecan or growth suppressor 1...
- The myotomal diwanka (lh3) glycosyltransferase and type XVIII collagen are critical for motor growth cone migrationValerie A Schneider
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Neuron 50:683-95. 2006..cloning of diwanka and show that it encodes LH3, a myotomally expressed multifunctional enzyme with lysyl hydroxylase and glycosyltransferase domains...
- Morphological and molecular analysis of idiopathic gingival fibromatosis: a case reportNicoletta Gagliano
Department of Human Morphology LITA Segrate, University of Milan, Milan, Italy
J Clin Periodontol 32:1116-21. 2005..As this overgrowth involves collagen accumulation in the gingival connective tissue, we measured the collagen turnover to clarify the pathogenic mechanisms potentially involved...
- Lack of collagen type specificity for lysyl hydroxylase isoformsC Wang
Department of Biochemistry, University of Oulu, Finland
DNA Cell Biol 19:71-7. 2000b>Lysyl hydroxylase is the enzyme catalyzing the formation of hydroxylysyl residues in collagens. Large differences in the extent of hydroxylysyl residues are found among collagen types...
- Cloning and characterization of a third human lysyl hydroxylase isoformK Passoja
Collagen Research Unit, Biocenter and Department of Medical Biochemistry, University of Oulu, FIN 90220 Oulu, Finland
Proc Natl Acad Sci U S A 95:10482-6. 1998b>Lysyl hydroxylase (EC 22.214.171.124), a homodimer, catalyzes the formation of hydroxylysine in collagens. Recently, an isoenzyme termed lysyl hydroxylase 2 has been cloned from human sources [M. Valtavaara, H. Papponen, A.-M. Pirttilä, K...
- Tissue specificity of a new splice form of the human lysyl hydroxylase 2 geneH N Yeowell
Division of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
Matrix Biol 18:179-87. 1999In this study we present the first report of alternative RNA splicing in a gene for lysyl hydroxylase (LH) in a normal population. This splicing event, which we have observed in the LH2 gene, appears to be tissue specific...
- A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblastsN Gagliano
Department of Human Morphology, Extracellular Matrix Laboratory EML, University of Milan, Milan, Italy
Transplant Proc 40:1419-24. 2008..Collagen type I and III (COL-I, COL-III), lysyl hydroxylase 2b (LH2b), MMP-1 and -2, tissue inhibitor of MMP-1 and transforming growth factor-beta1 (TGF-beta1) mRNA ..
- Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblastsLinda C Walker
Division of Dermatology, Duke University Medical Center, Durham, Box 3135, NC 27710, USA
Matrix Biol 23:515-23. 2005..b>Lysyl hydroxylase 2 (LH2) exists as two alternatively-spliced forms; the long transcript (the major ubiquitously-expressed ..
- Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situI Ishida
Department of Ophthalmology, Wakayama Medical University, Kimiidera, Japan
Graefes Arch Clin Exp Ophthalmol 239:770-7. 2001..Minoxidil is an inhibitor of lysyl hydroxylase, an enzyme involved in procollagen hydroxylation...
- Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2Russia Ha-Vinh
Division of Molecular Pediatrics, University of Lausanne, Lausanne, Switzerland
Am J Med Genet A 131:115-20. 2004..One BS locus has been mapped at 17p12, but more recently, two mutations in the lysyl hydroxylase 2 gene (PLOD2, 3q23-q24) have been identified in BS, showing genetic heterogeneity...
- Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3)K Rautavuoma
Collagen Research Unit, Biocenter and Department of Medical Biochemistry, University of Oulu, Kajaanintie 52 A, FIN 90220, Oulu, Finland
Matrix Biol 19:73-9. 2000b>Lysyl hydroxylase (LH) catalyzes the formation of hydroxylysine in collagens and related proteins by the hydroxylation of lysine residues in peptide linkages. Three isoenzymes of LH have so far been characterized...
- Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cellsRoman Thaler
Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna, Austria
Bone 46:703-9. 2010..increased the ratio of pyr/divalent cross-links of collagen, and down-regulated mRNA expression of lysyl hydroxylase (Plod2) and lysyl oxidase (Lox), genes which play an important role in the formation of a stable matrix...
- Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J miceK Reiser
Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA
Am J Physiol 271:R696-703. 1996..Expression of types I and III collagen, lysyl oxidase, and lysyl hydroxylase was increased in all tissues analyzed...
- Evidence that impaired intracellular collagen synthesis reduces proliferation in cultured rat hepatocytesH Ikeda
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Biochem Biophys Res Commun 200:1701-7. 1994..The addition of P-1894B or minoxidil, which inhibits specifically prolyl hydroxylase or lysyl hydroxylase, respectively, also produced similar results...
- PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5Mrudula Ganga
Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
J Biol Chem 278:22437-45. 2003..5. We further demonstrate that the procollagen lysyl hydroxylase (PLOD1) promoter is regulated by Nkx2.5. Mechanistically, PITX2C and Nkx2...
- Penicillin G does not alter collagen type I metabolism of dermal fibroblasts in cultureU Anderegg
Department of Dermatology, Leipzig University, and Saxon Academy of Science, Leipzig, Germany
Dermatology 200:111-4. 2000..Penicillin G (PenG) has successfully been used for therapy of dermal fibrosis in patients suffering from systemic sclerosis (SSc). However, there is little knowledge on the mechanism of the antifibrotic action of PenG...
- cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylaseS Jia
Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
J Biol Chem 267:14322-7. 1992..amino acid sequences of two other alpha-ketoglutarate-dependent dioxygenases, prolyl-4-hydroxylase and lysyl hydroxylase, with that of Asp beta-hydroxylase showed no significant homologies...
- Genomic structure and embryonic expression of zebrafish lysyl hydroxylase 1 and lysyl hydroxylase 2Valerie A Schneider
University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, Philadelphia, PA 19104 6058, USA
Matrix Biol 26:12-9. 2007Collagen biosynthesis in both invertebrates and vertebrates is critically dependent upon the activity of lysyl hydroxylase (LH) enzymes...
- Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscleM Valtavaara
Biocenter and Department of Biochemistry, University of Oulu, FIN 90570 Oulu, Finland
J Biol Chem 272:6831-4. 1997We report the isolation and characterization of cDNA clones for a novel isoform of lysyl hydroxylase (lysyl hydroxylase 2), a posttranslational enzyme of collagen biosynthesis...
- Lingual leiomyomatous hamartoma with bifid tip and ankyloglossia in a patient without oral-facial-digital syndrome: a case report and literature reviewHsing Liang Wang
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
World J Surg Oncol 11:230. 2013Here is a rare case of lingual leiomyomatous hamartoma (LLH) with bifid tongue tip and tongue-tie in a patient with non-oral-facial-digital syndrome (OFDS)...
- Characterization of a mutant strain of Rhodovulum sulfidophilum lacking the pufA and pufB genes encoding the polypeptides for the light-harvesting complex 1 (B 870)Laura J Raiger-Iustman
Catedra de Microbiologia, Facultad de Agronomia, UBA and Instituto de Investigaciones Bioquímicas y Fisiológicas IByF CONICET, Av San Martin 4453, 1417, Capital Federal, Argentina
Arch Microbiol 185:407-15. 2006..complex 2 (LH2) directly to the reaction center (RC) in mutant strains lacking the core light-harvesting complex 1 (LH1) have been obtained with cells of Rhodobacter capsulatus and Rhodobacter sphaeroides...
- Projection structure of the photosynthetic reaction centre-antenna complex of Rhodospirillum rubrum at 8.5 A resolutionStuart J Jamieson
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
EMBO J 21:3927-35. 2002Two-dimensional crystals of the reaction-centre-light-harvesting complex I (RC-LH1) of the purple non- sulfur bacterium Rhodospirillum rubrum have been formed from detergent-solubilized and purified protein complexes...
- Excitation dynamics of two spectral forms of the core complexes from photosynthetic bacterium Thermochromatium tepidumFei Ma
Beijing National Laboratory for Molecular Science, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Biophys J 95:3349-57. 2008The intact core antenna-reaction center (LH1-RC) core complex of thermophilic photosynthetic bacterium Thermochromatium (Tch.) tepidum is peculiar in its long-wavelength LH1-Q(y) absorption (915 nm)...
- Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfectaWayne A Cabral
Bone and Extracellular Matrix Branch, NICHD, NIH, Bethesda, Maryland, United States of America
PLoS Genet 10:e1004465. 2014..We confirmed and extended the reported role of CyPB in supporting collagen lysyl hydroxylase (LH1) activity...
- Construction and structural analysis of tethered lipid bilayer containing photosynthetic antenna proteins for functional analysisAyumi Sumino
Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso cho, Showa Ku, Nagoya 466 8555, Japan
Biomacromolecules 12:2850-8. 2011..bacterial photosynthetic membrane proteins, light-harvesting complex 2 (LH2), and light-harvesting core complex (LH1-RC) is described and establishes this system as an experimental platform for their functional analysis...
- Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targetsSamantha Gadd
Department of Pathology, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
Lab Invest 90:724-38. 2010....
- Energy transfer and charge separation in the purple non-sulfur bacterium Roseospirillum parvumH P Permentier
Department of Biophysics, Huygens Laboratory, Leiden University, The Netherlands
Biochim Biophys Acta 1460:338-45. 2000..6 ps. This and other evidence indicate that both types of BChl belong to a single LH1 complex. Flash induced difference spectra show that the primary electron donor absorbs at 886 nm, i.e...
- Natronovirga wadinatrunensis gen. nov., sp. nov. and Natranaerobius trueperi sp. nov., halophilic, alkalithermophilic micro-organisms from soda lakes of the Wadi An Natrun, EgyptNoha M Mesbah
Department of Microbiology, University of Georgia, Athens, GA 30602, USA
Int J Syst Evol Microbiol 59:2042-8. 2009..nov. Strain JW/NM-WN-LH1T represents a novel genus and species within the family Natranaerobiaceae, Natronovirga wadinatrunensis gen. nov., sp. nov. The type strain of the type species is JW/NM-WN-LH1T (=DSM 18770T=ATCC BAA-1444T)...
- Evaluation of structure-function relationships in the core light-harvesting complex of photosynthetic bacteria by reconstitution with mutant polypeptidesC M Davis
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
Biochemistry 36:3671-9. 1997Seven mutant LH1 polypeptides of Rhodobactor sphaeroides have been isolated, and their behaviors in in vitro reconstitution of LH1 and its subunit complex have been characterized...
- Reconstitution of bacterial photosynthetic unit in a lipid bilayer studied by single-molecule spectroscopy at 5 KDaisuke Uchiyama
Department of Physics, Tokyo Institute of Technology, Tokyo 152 8551, Japan
Phys Chem Chem Phys 13:11615-9. 2011..a lipid bilayer by reconstitution of the light-harvesting 2 (LH2) complex and light-harvesting 1-reaction center (LH1-RC) complex through detergent removal of their micelles in the presence of lipids...
- Oxygen tension regulates the expression of a group of procollagen hydroxylasesKarl Heinz Hofbauer
Institut für Physiologie der Universität Regensburg, Germany
Eur J Biochem 270:4515-22. 2003..involved in collagen fiber formation, such as prolyl-4-hydroxylases (Ph4) and procollagen lysyl-hydroxylases (PLOD)...
- Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrixMaija Risteli
Department of Biochemistry, P O Box 3000, University of Oulu, FI 90014 Oulu, Finland
J Biol Chem 284:28204-11. 2009b>Lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase, collagen galactosyltransferase, and glucosyltransferase (GGT) activities...
- Mutational analysis of the lysyl hydroxylase 1 gene (PLOD) in six unrelated patients with Ehlers-Danlos syndrome type VI: prenatal exclusion of this disorder in one familyH N Yeowell
Duke University Medical Center, Durham, NC 27710, USA
Hum Mutat 16:90. 2000Screening of full length cDNAs for lysyl hydroxylase 1 (LH1; also PLOD) amplified from dermal fibroblasts from six unrelated patients with the autosomal recessive disorder Ehlers-Danlos syndrome type VI (EDS VI) has shown them to be both ..
- A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cellsHengwen Yang
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Nat Commun 6:5717. 2015..However, several studies suggest that PSR may also act as an arginine demethylase, a lysyl hydroxylase, or an RNA-binding protein through its N-terminal JmjC domain...
- Probing binding site of bacteriochlorophyll a and carotenoid in the reconstituted LH1 complex from Rhodospirillum rubrum S1 by Stark spectroscopyKatsunori Nakagawa
Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso cho, Nagoya, 466 8555, Japan
Photosynth Res 95:339-44. 2008..Tr(Deltaalpha) and static dipole-moment change |Deltamu| upon photoexcitation) of isolated and of reconstituted LH1 complexes from the purple photosynthetic bacterium, Rhodospirillum (Rs.) rubrum...
- Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cellsSuchaya Pornprasertsuk
Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7455, USA
J Bone Miner Res 19:1349-55. 2004..The data indicate that LH2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues...
- Atomic force microscopy reveals multiple patterns of antenna organization in purple bacteria: implications for energy transduction mechanisms and membrane modelingJames N Sturgis
Laboratoire d Ingenierie des Systemes Macromoleculaires, Institute de Biologie Structurale et Microbiologie, UPR 9027, CNRS, 31 Chemin Joseph Aiguier, Marseille, 13402, France
Photosynth Res 95:269-78. 2008..LH2 antenna was seen either in large clusters or in fixed rows interspersed among ordered arrays of dimeric LH1-reaction center (RC) core complexes...
- Monitoring response to treatment in melanoma patients: potential of a serum glycomic markerSenthamil R Selvan
Cell Biology Laboratory, Hoag Cancer Center, Newport Beach, CA 92663, USA
Int J Cancer 122:1374-83. 2008..volunteers on weeks 0, 4 and 24, patients were categorized into cohorts-I (LLL, n = 16), II (HHL/HLL, n = 4), III (LLH/LHH/LHL, n = 7) and IV (HHH/HLH, n = 7)...
- Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinomaAkira Kurozumi
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
Int J Oncol 48:1837-46. 2016..Thus, our data showed that two genes promoting metastasis, LOXL2 and PLOD2, were epigenetically regulated by tumor-suppressive microRNAs, miR-26a and miR-26b, providing important insights into the molecular mechanisms of RCC metastasis...
- Expression profile of proteins involved in scar formation in the healing process of full-thickness excisional wounds in the porcine modelMagda M W Ulrich
Association of Dutch Burn Centres, Beverwijk, The Netherlands
Wound Repair Regen 15:482-90. 2007..This type of cross-linking is dependent on the enzyme lysyl hydroxylase-2b...
- Ciliate ingestion and digestion: flow cytometric measurements and regrowth of a digestion-resistant Campylobacter jejuniMatthew R First
Department of Geology and Geophysics, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
J Eukaryot Microbiol 59:12-9. 2012..Campylobacter and the nonpathogenic bacterium Pseudomonas putida LH1 were labeled with a 5-chloromethylfluorescein diacetate, which fluoresces in intact and active cells but fades when ..
- Maternal dietary n-6/n-3 fatty acid ratio affects type 1 diabetes development in the offspring of non-obese diabetic miceYukiko Kagohashi
Department of Health and Nutrition, The University of Shimane, Matsue, Shimane, Japan
Congenit Anom (Kyoto) 50:212-20. 2010..combined L and H chows during gestation, lactation in mother and in post-weaning offspring revealed that only the LLH chow significantly suppressed the development of diabetes with similar kinetics to LLL chow, although the other ..
- Investigation of Rhodobacter capsulatus PufX interactions in the core complex of the photosynthetic apparatusMuktak Aklujkar
Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, BC, Canada
Photosynth Res 88:159-71. 2006..the genus Rhodobacter includes a core complex consisting of the reaction centre (RC), light-harvesting complex 1 (LH1), and the PufX protein. PufX modulates LH1 structure and facilitates photosynthetic quinone/quinol exchange...
- Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6Monica Mantri
Department of Chemistry and Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
J Mol Biol 401:211-22. 2010..Together with mutational studies, the structural data suggest how JMJD6 binds its lysyl residues such that it can catalyse C-5 hydroxylation rather than Nepsilon-demethylation, as for analogous enzymes...
- Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis BullosaStephen A Watt
Division of Cancer Research, University of Dundee, Dundee, United Kingdom
PLoS ONE 10:e0137639. 2015..identify a significant decrease in PLOD3 expression and its encoded protein, the collagen modifying enzyme lysyl hydroxylase 3 (LH3), in RDEB...
- Probing the effect of the binding site on the electrostatic behavior of a series of carotenoids reconstituted into the light-harvesting 1 complex from purple photosynthetic bacterium Rhodospirillum rubrum detected by stark spectroscopyKatsunori Nakagawa
Department of Life and Materials Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, Japan
J Phys Chem B 112:9467-75. 2008Reconstitutions of the LH1 complexes from the purple photosynthetic bacterium Rhodospirillum rubrum S1 were performed with a range of carotenoid molecules having different numbers of C=C conjugated double bonds...
- The origin of the unusual Qy red shift in LH1-RC complexes from purple bacteria Thermochromatium tepidum as revealed by Stark absorption spectroscopyFei Ma
Department of Biophysics, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands Electronic address
Biochim Biophys Acta 1847:1479-86. 2015Native LH1-RC of photosynthetic purple bacteria Thermochromatium (Tch.) tepidum, B915, has an ultra-red BChl a Qy absorption...
- Platelet factor 4 gene transfection into tumor cells inhibits angiogenesis, tumor growth and metastasisKentaro Yamaguchi
Department of Surgery, Tokyo Women s Medical University Daini Hospital, 2 1 10 Nishiogu, Arakawa ku Tokyo, 116 8567, Japan
Anticancer Res 25:847-51. 2005..In this study, Lewis lung carcinoma (LLH) cells were transfected with the human PF4 via mammalian expression vectors and the ability of the transfected ..
- From the left to the right: 13-year experience in laparoscopic living donor liver transplantationRaffaele Brustia
Department of Hepatobiliary Surgery and Liver Transplantation, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83 boulevard de l Hopital, 75013, Paris, France
Updates Surg 67:193-200. 2015..Laparoscopic Left Lateral Section (LLLS) was performed in children receiver, while Laparoscopic Left Hepatectomy (LLH)-including or not the middle hepatic vein-and Laparoscopic Right Hepatectomy (LRH) in adults...
- In vivo carotenoid triplet formation in response to excess light: a supramolecular photoprotection mechanism revisitedJean Alric
Laboratoire de Genetique et Biophysique des Plantes, UMR, 6191 CNRS CEA Aix Marseille II, France
Photosynth Res 83:335-41. 2005..work, we investigate the coupling between energy conversion and energy deactivation, in isolated complexes of RC-LH1 and LH2 increasingly integrated systems up to intact cells of the purple anaerobic photosynthetic bacterium ..
- Crystal structure of the RC-LH1 core complex from Rhodopseudomonas palustrisAleksander W Roszak
Department of Chemistry, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Science 302:1969-72. 2003The crystal structure at 4.8 angstrom resolution of the reaction center-light harvesting 1 (RC-LH1) core complex from Rhodopseudomonas palustris shows the reaction center surrounded by an oval LH1 complex that consists of 15 pairs of ..
- Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2Marjo Hyry
Oulu Center for Cell Matrix Research, Biocenter Oulu, and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
J Biol Chem 284:30917-24. 2009..Three point mutations in lysyl hydroxylase (LH) 2, the enzyme responsible for the hydroxylation of collagen telopeptides, have been identified in Bruck ..
- Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3)Chunguang Wang
Department of Biochemistry, Biocenter Oulu, University of Oulu, P O Box 3000, University of Oulu, FIN 90014, Finland
J Biol Chem 277:18568-73. 2002Collagen glucosyltransferase (GGT) activity has recently been shown to be associated with human lysyl hydroxylase (LH) isoform 3 (LH3) (Heikkinen, J., Risteli, M., Wang, C., Latvala, J., Rossi, M., Valtavaara, M., Myllylä, R. (2000) J...
- A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 geneAntti M Salo
Department of Biochemistry, University of Oulu, PO Box 3000, FI 90014 University of Oulu, Finland
Am J Hum Genet 83:495-503. 2008b>Lysyl hydroxylase 3 (LH3, encoded by PLOD3) is a multifunctional enzyme capable of catalyzing hydroxylation of lysyl residues and O-glycosylation of hydroxylysyl residues producing either monosaccharide (Gal) or disaccharide (Glc-Gal) ..
- A case of Ehlers-Danlos syndrome type VIA with a novel PLOD1 gene mutationAyse Tosun
Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey Electronic address
Pediatr Neurol 51:566-9. 2014..The kyphoscoliotic type of the Ehlers-Danlos syndrome is an autosomal recessive connective tissue disorder characterized by soft extensible skin, laxity of joints, severe muscle hypotonia at birth, and kyphoscoliosis...
- Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activityJ Heikkinen
Department of Biochemistry, University of Oulu, P O Box 3000, FIN 90014 Oulu, Finland
J Biol Chem 275:36158-63. 2000b>Lysyl hydroxylase (EC ) and glucosyltransferase (EC ) are enzymes involved in post-translational modifications during collagen biosynthesis...
- Vitamin C and bone markers: investigations in a Gambian populationKaren Munday
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
Proc Nutr Soc 62:429-36. 2003..Vitamin C acts as a cofactor for the enzyme lysyl hydroxylase, which is required for the hydroxylation of lysine residues in procollagen chains...
- Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitusM Saito
Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
Osteoporos Int 21:195-214. 2010..Collagen cross-links can be divided into lysyl hydroxylase and lysyloxidase-mediated enzymatic immature divalent cross-links,mature trivalent pyridinoline and pyrrole ..
- Glycosylation and cross-linking in bone type I collagenMasahiko Terajima
From the North Carolina Oral Health Institute, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599
J Biol Chem 289:22636-47. 2014..Perdivara, I., Yokoyama, M., Nagaoka, H., Terajima, M., Tomer, K. B., and Yamauchi, M. (2012) Lysyl hydroxylase 3-mediated glucosylation in type I collagen: molecular loci and biological significance. J. Biol. Chem...
- Excitation energy transfer and trapping dynamics in the core complex of the filamentous photosynthetic bacterium Roseiflexus castenholziiYueyong Xin
Departments of Biology and Chemistry, Washington University, St Louis, MO 63130, USA
Photosynth Res 111:149-56. 2012..Assuming that the light harvesting complex is generally similar to LH1 of purple bacteria, the possible structural and functional aspects of this unique antenna complex are discussed...
- Ca(2+)-binding reduces conformational flexibility of RC-LH1 core complex from thermophile Thermochromatium tepidumSelma Jakob-Grun
Department Biology I, Botany, Ludwig Maximilians University Munich, 82152, Planegg Martinsried, Germany
Photosynth Res 111:139-47. 2012The light-harvesting complex, LH1, of thermophile purple bacteria Thermochromatium tepidum consists of an array of α- and β-polypeptides which assemble the photoactive bacteriochlorophyll and closely interact with the membrane-lipids...
- Molecular cloning of chick lysyl hydroxylase. Little homology in primary structure to the two types of subunit of prolyl 4-hydroxylaseR Myllyla
Collagen Research Unit, University of Oulu, Finland
J Biol Chem 266:2805-10. 1991b>Lysyl hydroxylase (EC 188.8.131.52), an alpha 2 dimer, catalyzes the formation of hydroxylysine in collagens by the hydroxylation of lysine residues in X-Lys-Gly sequences...
- Isolation, size estimates, and spectral heterogeneity of an oligomeric series of light-harvesting 1 complexes from Rhodobacter sphaeroidesWillem H J Westerhuis
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854 8082, USA
Biochemistry 41:8698-707. 2002A series of light-harvesting 1 (LH1) complexes was isolated by lithium dodecyl sulfate-polyacrylamide gel electrophoresis at 4 degrees C from Rhodobacter sphaeroides M21, which lacks the peripheral light-harvesting 2 (LH2) complex...
- Excited state dynamics in photosynthetic reaction center and light harvesting complex 1Johan Strumpfer
Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Chem Phys 137:065101. 2012..the purple photosynthetic bacterium Rhodobacter sphaeroides studied here, surrounded by light harvesting complex 1 (LH1)...
- Polarization angle dependence of stark absorption spectra of spirilloxanthin bound to the reconstituted LH1 complexes using LH1-subunits isolated from the purple photosynthetic bacterium Rhodospirillum rubrumTomoko Horibe
Department of Physics, Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi ku, Japan
Acta Biochim Pol 59:97-100. 2012Reconstituted LH1 complexes were prepared using the LH1 subunit-type complexes, isolated from the purple photosynthetic bacterium Rhodospirillum (Rs.) rubrum, and purified all-trans spirilloxanthin...
- Dynamics of excitation energy transfer in the LH1 and LH2 light-harvesting complexes of photosynthetic bacteriaR van Grondelle
Department of Biophysics and Physics of Complex Systems, Faculty of Sciences, Vrije Universiteit, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands
Biochemistry 40:15057-68. 2001..We are now in a position to discuss the physical origins of excitation energy transfer and trapping in the LH2 and LH1 antennae of photosynthetic purple bacteria...
- Differential effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on gene expression of collagen-modifying enzymes in human adipose tissue-derived mesenchymal stem cellsMarlene Knippenberg
Department of Oral Cell Biology, Academic Centre of Dentistry Amsterdam ACTA, Universiteit van Amsterdam, and Research Institute MOVE, Vrije Universiteit, Amsterdam, The Netherlands
Tissue Eng Part A 15:2213-25. 2009..AT-MSCs may thus be able to appropriately modify type I collagen to form a functional bone extracellular matrix for tissue engineering, dependent on the growth factor added...
- Combination of Genistein and Cisplatin with Two Designed Monofunctional Platinum Agents in Human Ovarian Tumour ModelsLaila Arzuman
Discipline of Biomedical Science, Sydney Medical School, The University of Sydney, Cumberland Campus, Lidcombe, NSW, Australia
Anticancer Res 35:6027-39. 2015..we report the synthesis of monofunctional platinum tris(3-hydroxypyridine)chloroplatinum(II) chloride (coded as LH1) and tris(imidazole)chloroplatinum(II) chloride (coded as LH2), and their activity alone and in combination with ..
- Discovery and characterization of hydroxylysine in recombinant monoclonal antibodiesQing Xie
a Protein Analytical Chemistry Department, Genentech, 1 DNA Way, 94080, South San Francisco, CA, USA
MAbs 8:371-8. 2016..proteins such as collagen, and was therefore presumed to result from the activity of the CHO homolog of the lysyl hydroxylase complex...
- Role of the C-terminal extrinsic region of the alpha polypeptide of the light-harvesting 2 complex of Rhodobacter sphaeroides: a domain swap studyJohn D Olsen
Robert Hill Institute for Photosynthesis, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, United Kingdom
Biochemistry 42:15114-23. 2003The LH1 and LH2 complexes of Rhodobacter sphaeroides form ring structures of 16 and 9 protomers, respectively, comprising alpha and beta polypeptides, bacteriochlorophylls (Bchl), and carotenoids...
- Ultra-broadband 2D electronic spectroscopy of carotenoid-bacteriochlorophyll interactions in the LH1 complex of a purple bacteriumMargherita Maiuri
CNR IFN, Dipartimento di Fisica, Politecnico di Milano, P zza L Da Vinci 32, Milano 20133, Italy
J Chem Phys 142:212433. 2015We investigate the excitation energy transfer (EET) pathways in the photosynthetic light harvesting 1 (LH1) complex of purple bacterium Rhodospirillum rubrum with ultra-broadband two-dimensional electronic spectroscopy (2DES)...
- Self-assembled monolayer of light-harvesting core complexes from photosynthetic bacteria on a gold electrode modified with alkanethiolsMasaharu Kondo
Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso cho, Showa Ku, Nagoya 466 8555, Japan
Biomacromolecules 8:2457-63. 2007Light-harvesting antenna core (LH1-RC) complexes isolated from Rhodoseudomonas palustris were self-assembled on a gold electrode modified with self-assembled monolayers (SAMs) of the alkanethiols NH2(CH2)nSH, n = 2, 6, 8, 11; HOOC(CH2)..
- Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencingHaruya Sakai
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama, Japan
Hum Genet 131:591-9. 2012..Next-generation sequencing was able to detect almost all types of mutation, but requires improved informatics methods...
- Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenonAnnemarie J van der Slot
TNO Prevention and Health, Biomedical Research Division, Department of Tissue Repair, PO Box 2215, 2301 CE Leiden, The Netherlands
Matrix Biol 23:251-7. 2004..This is consistent with our previous observation that LH2b is a telopeptide lysyl hydroxylase. We conclude that the increased expression of LH2b, leading to the increased formation of pyridinoline cross-..
- The nature of coherences in the B820 bacteriochlorophyll dimer revealed by two-dimensional electronic spectroscopyMarco Ferretti
VU University, Amsterdam, The Netherlands
Phys Chem Chem Phys 16:9930-9. 2014..2DES to an excitonically coupled bacteriochlorophyll dimer, the B820 subunit of the light harvesting complex 1 (LH1-RC) of R. rubrum G9...
- A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of ItoH V Toriello
Cytogenetics Laboratory, Butterworth Hospital, Grand Rapids, Michigan 49503, USA
Nat Genet 13:361-5. 1996..types I and III have been demonstrated in EDS types VII and IV, respectively, while mutations in the lysyl hydroxylase and ATP7A genes, with roles in collagen cross-linking, are responsible for EDS types VI and IX...
- Hydrophobic pockets at the membrane interface: an original mechanism for membrane protein interactionsVeronique Arluison
Service de Biophysique des Fonctions Membranaires, DBJC CEA and URA 2096 CNRS, CE Saclay, 91191 Gif Yvette cedex, France
Biochemistry 43:1276-82. 2004The effect of partial digestion by trypsin and GluC protease on the association of the membrane polypeptides of LH1 from Rhodospirillum (Rsp.) rubrum was studied...
- Nanodissection and high-resolution imaging of the Rhodopseudomonas viridis photosynthetic core complex in native membranes by AFM. Atomic force microscopySimon Scheuring
Institut Curie, Unité Mixte de Recherche Centre National de la Recherche Scientifique 168 and Laboratoire de Recherche Correspondant Commissariat à l Energie Atomique 34V, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France
Proc Natl Acad Sci U S A 100:1690-3. 2003..vertical resolution reveal a single reaction center (RC) surrounded by a closed ellipsoid of 16 light-harvesting (LH1) subunits...
- Monomeric RC-LH1 core complexes retard LH2 assembly and intracytoplasmic membrane formation in PufX-minus mutants of Rhodobacter sphaeroidesPeter G Adams
Department of Molecular Biology and Biochemistry, University of Sheffield, United Kingdom
Biochim Biophys Acta 1807:1044-55. 2011..of light-harvesting 2 (LH2) complexes surround and interconnect dimeric reaction centre-light-harvesting 1-PufX (RC-LH1-PufX) 'core' complexes, forming extensive networks for energy transfer and trapping...
- Secretion and assembly of type IV and VI collagens depend on glycosylation of hydroxylysinesLaura Sipilä
Biocenter Oulu, Department of Biochemistry, University of Oulu, FI 90014 Oulu, Finland
J Biol Chem 282:33381-8. 2007..The formation of glycosylated hydroxylysines is catalyzed by multifunctional lysyl hydroxylase 3 (LH3) in vivo, and we have used LH3-manipulated mice and cells as models to study the function of these ..
- Reaction mechanism of CO oxidation on Cu(2)O(111): A density functional studyBao Zhen Sun
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, People s Republic of China
J Chem Phys 133:154502. 2010..Four possible mechanisms are explored (denoted as M(ER1), M(ER2), M(LH1), and M(LH2), respectively): M(ER1) is CO((gas))+O(2(ads))→CO(2(gas)); M(ER2) is CO((gas))+O(2(ads))→CO(3(ads))�..
- Spectroscopic characterisation of a tetrameric subunit form of the core antenna protein from Rhodospirillum rubrumAttila P Vegh
Section de Biophysique des Fonctions Membranaires, DBJC CEA et URA CNRS 2096 C E A Saclay, 91191 Gif Yvette cedex, France
FEBS Lett 528:222-6. 2002The core light-harvesting complex (LH1) of Rhodospirillum rubrum is constituted of multiple heterodimeric subunits, each containing two transmembrane polypeptides, alpha and beta...
- Subtle spectral effects accompanying the assembly of bacteriochlorophylls into cyclic light harvesting complexes revealed by high-resolution fluorescence spectroscopyMargus Rätsep
Institute of Physics, University of Tartu, Riia 142, 51014 Tartu, Estonia
J Chem Phys 141:155102. 2014..the bacteriochloropyll a molecules into B850 and B875 groups of cyclic bacterial light-harvesting complexes LH2 and LH1, respectively, results an almost total loss of the intra-molecular vibronic structure in the fluorescence spectrum, ..
- Characterization of a highly purified, fully active, crystallizable RC-LH1-PufX core complex from Rhodobacter sphaeroidesE C Abresch
Department of Physics, University California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Photosynth Res 86:61-70. 2005..We describe the isolation of a highly purified, active, reaction center-light-harvesting 1-PufX complex (RC-LH1-PufX core complex) from a strain of the photosynthetic bacterium, Rhodobacter sphaeroides, which lacks the light-..
Research Grants21
- Collagen remodeling and tumor progressionValerie Marie Weaver; Fiscal Year: 2013..The lysyl oxidase and lysyl hydroxylase family of enzymes are also expressed in the stroma where they cross-link collagen fibrils to enhance the ..
- Collagen Glycosylation, Maturation and MineralizationMitsuo Yamauchi; Fiscal Year: 2013..Most recently we have demonstrated that lysyl hydroxylase 3 functions as GGT and, possibly, glycosyltransferase 25 family member 1 (GLT25D1) as GT for bone type I ..
- SKIN REACTION TO LIGHT--NORMAL, PHOTOSENSITIVITY, CANCERMADHUKAR PATHAK; Fiscal Year: 1992..determination of Type I and III collagen, cross-links and collagen, changes in 4-OH-prolyl-4'- hydroxylase, lysyl hydroxylase, desmosine, isodesmosine, and proteoglycans and evaluation of the role of certain free radical scavengers ..
- MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSEAnthony Visco; Fiscal Year: 2002..for the cross-linking process and the level of hydroxylation varies among tissues, Lysyl oxidase and lysyl hydroxylase are two enzymes involved in the early steps of the cross-linking process...
- COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTSSheldon Pinnell; Fiscal Year: 1999..mechanisms responsible for: (1) Inhibition of collagen synthesis by benzoic hydrazide; and (2) inhibition of lysyl hydroxylase expression by minoxidil...
- LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATIONJerold Last; Fiscal Year: 1992..collagen" from "normal collagen" in the lung; (ii) that this difference is mediated by increased activity of lysyl hydroxylase in the (pre)fibrotic lung; and (iii) that once crosslinked, "fibrotic collagen" in the lung is not subject ..
- REGULATION OF COLLAGEN MATRIX MINERALIZATIONMitsuo Yamauchi; Fiscal Year: 2007..To establish osteoblastic cell clones that synthesize low levels of lysyl hydroxylase-2 to switch the cross-linking pathway from mineralized to non-mineralized tissue phenotype, 1b...
- Phase 3A of a 3-phase 1.3-GHz LTS/HTS NMR magnetYUKIKAZU NA IWASA; Fiscal Year: 2013..3 GHz LTS/HTS NMR magnet (LH1.3G)...
- CHARACTERIZATION OF MEMBRANE PROTEIN BY SSNMRAnn McDermott; Fiscal Year: 2001..and side-chain chemical shifts of hydrated micro-crystalline U-13C, 15N BPTI and of the intrinsic membrane protein, LH1. Typical 13C peak linewidths are 0...
- Structural Studies of Photosynthetic Membrane ProteinsMATTHEW CRADDOCK; Fiscal Year: 2007..understanding of this efficiency is a detailed structural knowledge of the major components of the antenna system, LH1, LH2, and the Reaction Center (RC), which are all membrane proteins...
- MEMBRANE PROTEINS--STRUCTURE, DYNAMICS AND STABILITYCRAIG SCHENCK; Fiscal Year: 2002..b>LH1 protein, a 200 kD hetero-oligomeric membrane protein from photoheterotrophic eubacteria, undergoes multiple ..
- CLIENTS WHO SEEK ON-LINE DRUG TREATMENTMAMIE WONG; Fiscal Year: 2003..Without this "cultural competence," investigators may plod forth with increasingly complex studies that yield equally complex findings, with unknown generalizability to ..
- CHARACTERIZATION OF LYSYL HYDROXYLASE ISOFORMS IN SKINHeather Yeowell; Fiscal Year: 2008..The identity of the telopeptide lysyl hydroxylase therefore becomes important to establish...
- TWO CANDIDATE GENES LINKED TO LOW BONE DENSITYLORETTA SPOTILA; Fiscal Year: 2001..Two candidate genes located within this interval are PLOD, the gene for lysyl hydroxylase, and TNFR2, the gene for tumor necrosis factor-alpha receptor 2...
- COLLAGEN CROSS-LINKING IN SKELETAL AGING AND DISEASEDavid R Eyre; Fiscal Year: 2010..In parallel with basic tissue studies, collagen fragments in urine are being examined by similar methods as potential non-invasive biomarkers of a patient's bone and joint health. ..
- ACTIVATION OF TONGUE MUSCLES IN OBSTRUCTIVE SLEEP APNEADominique Durand; Fiscal Year: 2004..It is anticipated that the experimental delineation and validation of these methods will lead to a design of a neuroprosthetic device for the treatment of OSA. ..
- Collagen type II/IX/XI heteropolymer assemblyRUSSELL FERNANDES; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGEKaren Yates; Fiscal Year: 2005..This work will also provide a solid foundation for future research on Wnts in cartilage biology. ..
- Analysis & Control of Non-Synaptic Epileptiform ActivityDominique Durand; Fiscal Year: 2004..The results of our studies should provide valuable insight into mechanisms underlying epileptogenesis as well as new tools for the control and suppression of epileptic seizures. ..
- TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBPKaren Yates; Fiscal Year: 2004..We will determine which DBP-regulated transcription factors are necessary and/or sufficient for postnatal chondrogenesis. This proposed work would have a high impact of design of strategies for repair and/or regeneration of cartilage. ..


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- Services
- We strive to provide complete care for our patients. Learn more about all the services we provide.
Uniontown Veterinary Clinic: Your Veterinary Resource for Uniontown, Hartville and Green
We welcome you to the official website of Uniontown Veterinary Center, serving dogs and cats in Uniontown, Hartville and Green, Ohio. We look forward to serving as your pet's "other best friend" by providing a lifetime of health and wellness services, from fundamentals such as wellness checkups and pet dental care to advanced techniques such as pet laser surgery. We know you expect no less for any other member of your family, and we value your animals as if they were our own.
Great veterinary care begins with a great veterinary team. If you've been looking for that skilled, experienced, compassionate Hartville, Uniontown or Green veterinarian who will bond with your pet and serve as your trusted advisor, you'll be delighted to know that there are no fewer than three of them here at Uniontown Veterinary Clinic. Whichever Uniontown, Green and Hartville veterinarian works with your pet -- Dr. Joe Gainey, Dr. Denise Baltic or Dr. Vedessa Meluch -- you can rest assured that your beloved companion is on good hands. We always explain any conditions, concerns and procedural options to the owners who place their faith in us so they always know what we're doing and what needs to be done next. We're also happy to educate owners on best practices for taking care of pets at home, from dental hygiene to proper dietary habits.
Pets and owners alike can relax at Uniontown Veterinary Clinic. We maintain quiet, kid-friendly waiting rooms and offices to promote a peaceful and positive environment. (This can be especially important for cats, which generally prefer an atmosphere of serenity wherever possible.)
A Variety of Services from Our Hartville, Uniontown and Green Veterinarian
Your Hartville, Uniontown and Green veterinarian can provide comprehensive services to keep generations of cats and dogs feeing their best at all stages of life. We emphasize preventative wellness exams, pet dental care, spay/neuter surgery, vaccinations, parasite prevention and other helpful procedures to keep diseases at bay. If your pet does fall prey to illness or injury, our vet clinic is ready to provide assistance up to and including pet laser surgery. Our in-house laboratory and sophisticated diagnostic equipment ensures that your pet gets the right help as soon as possible.
Our vet clinic also provides important services for pets that are on the mend from an illness or injury. We offer K-9 rehabilitation to help dogs regain strength, flexibility and neurological function. We also provide laser therapy for drug-free pain relief of chronic pain and to speed healing of soft tissue damage. We even offer canine reproductive services for dogs that require assistance with breeding or delivery.
Learn More about Our Uniontown Veterinarian
Ready to give your pets the Green, Uniontown and Hartville veterinarian they need for a lifetime of better health? We would love to meet them, and you. Call (330) 699-9937 to set up an initial appointment at Uniontown Veterinary Center today!
| Uniontown Veterinary Clinic | (330) 699-9937
3435 Grovemont St NW
Uniontown, OH 44685


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Jones & Sons Roofing Ltd
Jones & Sons Roofing Ltd is a Lead Roofing Specialists Covering Bedford, Stevenage, St Albans, Watford, Harlow and all surrounding areas
- Tel: 0800 535 3108
- Mob: 07501 755127
30 reviews
- Initial impression : 4.66 out of 5
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About Jones & Sons Roofing Ltd - Lead Roofing Specialists in Islington
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Contact us today to discuss your requirements or for free friendly, practical and helpful advice. We look forward to hearing from you.
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Reviews (30)
Jones & Sons Roofing Ltd have received 30 customer reviews.
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The reviewer found this trader while searching on TrustATrader.com
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The reviewer found this trader while searching on TrustATrader.com
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Is conveniently located near dining and entertainment as well as Mills, Empire Lakes Golf Course and Plaza Continental Factory Stores as well as easy access to I-10. Our newly renovated homes feature sleek white kitchen and bathroom cabinetry, walk-in BfKbo6rvP closets, fireplace, in-home washer dryer and private balcony. Get a workout in at the fitness center, have a tennis match or relax with friends poolside. You and your favorite pet can enjoy it all at Centre Club Apartments. Price range: $1,347-1,747.
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