text:
He came back with the hotdogs and gave me mine. I took my time eating mine and so did he. "Thanks." I said smiling as the game was ending. It was only seven when the game ended. And the Yankees won! "No problem. I'm just glad that the Yankees one." He said and I smiled "me too." I said he took my hand again and we slowly walked to the car. "Are you getting hungry?" He asked me "A little." I said and he smiled at me "good so am I. I'm in a mood for a good old hamburger. Are you?" He asked me "that sounds good." I said and he smiled "Is the diner by the beach good?" He asked "it's the best." I said "Okay we're going there then." He said and I smiled "Alright it sounds fine with me." I said and he smiled at me. We sat at a little table outside and ate our hamburgers and shared a basket of chili cheese fries. Afterwards we walked on the beach, we now know everything about each other. He has dated three girls and it never worked out between each person for different reasons. "Have you ever had a crush on a guy?" He asked me "Nope. I have been focusing on school and then sports." I said "So you have never kissed a guy before?" He asked me "Nope." I said "Well you're not missing anything." He said "Really now?" I asked my eyes were sparkling. "Lexie, you're eyes are breath taking." He said I smiled "thanks." I said and we walked to the car he looked at the clock. "I will get you home in time. Just barely but I will." He said and I smiled "don't worry my daddy isn't a big scary guy." I said and he laughed. "I don't want to risk it." He said I smiled "Okay." I said and we pulled up to my driveway. "Lexie I had fun would you like to go out again tomorrow?" He asked me "Sure I would love to. Where to?" I asked him "there is this dance at the beach. So you gotta wear a dress, maybe borrow one from your sisters." He joked "Oh I own dresses." I said and he smiled at me. "Good-night Lexie." He said "Good-night Ethan." I said watching him leave and then I walked in where everybody was waiting for me. "So?" Momma asked me "I have a date tomorrow night at the beach for the dance." I said "Oh I'm going!" Lyndsey, Savannah, and Colleen said and I rolled my eyes. "We're doing your make up." Savannah said "Sa, I don't need my make up done." I said and she rolled her eyes. "You're hopeless Alex." She said and I rolled my eyes. "Good-night everyone." I said walking up to my room. I knew later on us older girls would sneak up to the roof and talk all about my date like we did when they would go out with their crushes and everything. Now it's my turn to be in the spot light not theirs. Sure enough I got a note slid through my door. Lex, roof top midnight. I went back to my closet to figure out what to wear tomorrow. I know I would be wearing my flip-flops because they're cute and beach material. I found my cute silver sandals with the diamond straps and then my white summery short dress with my pink leggings. I can look girly when I want to, I quit being girly at the age of eight so I think I can go back to it for tomorrow. And I'm not over doing this because Colleen wears stuff like this to the beach all the time. I climbed up on the roof at ten 'till midnight and laid down looking at the stars. Lyndsey and Savannah came at five 'till and Colleen made it at midnight and looked at me. I pulled my knees to my chest and looked at them. "I had the tingly feeling the whole time, it was amazing, he held on my hand during and after the game. We went to the diner by the beach then walked on the beach and talked a lot. We know everything about each other now. He's awesome." I said and Colleen looked at me "Lex, you are starting to like him!" She said I nodded. "Way to go Lexie!" Savannah said and Lyndsey the worry wart out of us looked at me "Be careful, Lex but good job!" She said "Lyndseyloo I know." I said and she smiled at me. "We're doing your make up." Colleen said "No your not." I said "Okay fine. One day we will." She said "Okay maybe." I said and she rolled her eyes at me. "Hopeless I tell ya!" She said and we smiled at her. "Good night." I said "good night sissy." They said and I made it to bed and fell asleep in no time and I actually dreamed of a guy for the first time. I think I do like him and I agree with Lyndsey I do need to be careful with him because I don't want to be hurt. I have seen Lyndsey, Savannah, and Colleen cry many nights over broken hearts from guys and I have been lucky from not having to deal with that. The next day seems to go by fast and it's time for us all to get ready. I beat them to the shower and got out and walked into my room and locking my door so I could get ready in private. I put on my favorite thong and bra set with the little white bow, I put on my leggings and then my dress and I curled my hair and left it down. I applied mascara, eye liner, eye shadow, blush, and lip gloss. Yes I know how to do my make up I just don't like wearing it that much. I slipped my shoes on and walked down stairs. "Alexis Ann you did your make up?" Colleen said and I smiled at her "Why yes I did. All by myself." I said "you look beautiful." She said "Thank you." I said and smiled at daddy who was staring. "You have gone to the dark side."
© Copyright 2017 StephandBrutusandIzzy. All rights reserved.
Status: Finished
Genre: Young Adult
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Division 0-12 Flash Cards
by School Zone
Ages 9+
Grades 4th+
Made in the U.S.A.
Division 0-12 Flash Cards contains 104 problems that range from 4 + 2 to 144 to 12.
Is your child a math warrior? Getting unstuck is half the battle, and these flash cards will help your elementary school child learn to divide by lower numbers, and in the process, conquer their next timed test at school. To help your child get there, see the parent card for information covering the 5 Division Steps, answer checking, division terms and division equations, plus helpful hints on working with your child. We want your child to be successful in solving the "challenges" of math by providing the tools to develop these essential skills. That's why we've developed these division flash cards for kids in third, fourth and fifth grades.
What's in the Box?
52 Division Problem Cards, 3 Division Information Cards, 1 Parent Card

subset: commoncrawl


text:
Translate Spanish-English-Dutch website X-ploregroup
This project received 16 bids from talented freelancers with an average bid price of $327 USD.Get free quotes for a project like this
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Project Description
Proofread Spanish and translate English and Dutch of our website [url removed, login to view]
Experience with Wordpress would be appreciated.
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Please upgrade your browser for the best Refinery29 experience. Read more.
Ellen & Obama bust a move to "Crazy in Love."
As Mary-Kate and Ashley Olsen once sang, "Nobody tells the president what to do." Except that's a lie. Ellen tells the president what to do. She tells him to DANCE.
"Dennis Quaid is here!"
This Starbucks prank with Dennis Quaid from 2008 is one of the most beloved in the history of the show.
Christmas caroling with Britney Spears.
Did you know that "Womanizer" is now a Christmas carol?
Rob Lowe said he never breaks character.
Ellen said, "Challenge accepted." Also remember the Hawaii Chair?
Ellen's vision boards really work.
Oprah Winfrey is famously the only person to appear on the cover of O, The Oprah Magazine, save for one time when she was joined by Michelle Obama. In 2009, Ellen created an "O Yes I Can" vision board and photoshopped herself onto past covers in hopes of appearing on a future issue of O. She got her wish. Ellen joined Oprah on the December 2009 cover.


text:
MSc Courses run by UCL Genetics Institute
The course provides students with in-depth knowledge of the genetics of human disease and how this can be applied to improve healthcare through the development of diagnostic tests and therapeutic agents. They will also get a strong grounding in cutting edge research methods and techniques used by scientists.
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The individual owning this blog works for Oracle in Germany. The opinions expressed here are his own, are not necessarily reviewed in advance by anyone but the individual author, and neither Oracle nor any other party necessarily agrees with them.
< Solaris Features: Service Management Facility - Part 5: Conclusion | New tape library from Sun: Sun StorageTek SL3000 >
Solaris Features: Service Management Facility
Thursday, February 28. 2008
Solaris' Service Management Facility
Joerg Moellenkamp wrote a great 5-part tutorial about Solaris' Service Management Facility (SMF). Everybody who is working with SMFs but actually it not using efficiently should read Joerg's tutorial- it's absolutelly worth reading!
Weblog: Doomshammer's Weblog
Tracked: Feb 28, 15:13
You need a manifest for Service Management Facility. It´s simple service, so no complex property configurations or multiple instances. Then easySMF may a helpful tool for you. EasySMF is a web based tool to create simple manifests for direct import to th
Weblog: c0t0d0s0.org
Tracked: Apr 29, 09:58
The Deliverer's Knowledge: What's the max. number of IP instances per NIC?
An foreword by Jörg: This is the first blog entry written by Heiko. "the deliverer's knowledge" is just a working title and it's referring to the fact, that Heiko delivers vast knowledge on a daily basis at various customer sites. I just add the c0t0d0s0.
Weblog: c0t0d0s0.org
Tracked: Oct 28, 21:40
Display comments as (Linear | Threaded)
The LKSF book
The book with the consolidated Less known Solaris Tutorials is available for download here
Web 2.0
Thu, 13.10.2016 15:51
Funny thing, I just found out that there is no equivalent co mmand for Linux.
Mon, 26.09.2016 08:48
flash required? really?
Tue, 21.06.2016 15:47
Hello, it would be nice to ge t a version to print as a A5 b ooklet.
Thu, 16.06.2016 11:10
bootadm stuff like install-boo tloader is great since it's fo r the first time the same comm and for SPARC and X86.
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Germany License
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Is Microgenesis Business Systems Inc incorrect or missing key business information? Update your Hotfrog listing today.
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Microgenesis Business Systems is a leading Systems Integrator and IT Solution Provider in the Philippines. We have been in operation for 20 years, providing and fulfilling the IT requirements for our treasured clients. Our customer profile includes those belonging to the Top 5000 Corporation as well as the Small and Medium Enterprise.
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|Re:Seriously I'm kinda scared
|attached to A Google Maps Glitch Turned This Korean Fishing Town Into a 'Pokemon Go' Haven
|Re:Don't really care
|attached to BlackBerry's 'Classic' Smartphone Is About to Disappear
|Re:Your shitty product kills jobs?
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|attached to Ask Slashdot: What's Your Preferred Media Streaming Device?
|Re:uninstall the facebook app
|attached to Facebook Is Using Your Phone's Location To Suggest New Friends
|Re:Married with kids.
|attached to Ask Slashdot: Why Do You Want a 'Smart TV'?
|Re:Slashdot is dead
|attached to The NSA's Delightfully D&D-inspired Guide To the Internet
|attached to YouTube Is Guilty Of Criminal Racketeering, Grammy Winner Says
|attached to Campaign Demands Telecoms Unlock the FM Radio Found in Many Smartphones
|Re:an easier way to make up revenue.
|attached to Should You Pay Sales Tax on Internet Purchases? South Dakota Law Could Be The Test
|"If she..."
|attached to Top Silicon Valley Execs and Others Urge Congress To Fund K-12 Computer Science Education
|Re:'10 times more efficient' and xenon gas
|attached to NASA Gives Solar Ionic Propulsion A Monster Boost
|Re:I've been saying this for years!
|attached to CIA Is Investing Heavily In Firms That Do Social Media Mining and Surveillance
|Re:I'm just gonna throw this out here
|attached to How San Francisco Hazed a Tech Bro
|attached to FBI Unlocks iPhone Without Apple's Help In San Bernadino Case
|Re: The longer you wait...
|attached to Oculus Rift Review: Virtual Reality is Almost Here
|Re:Ah. slashdot...
|attached to Yellowstone Supervolcano Eruptions Even Bigger Than Originally Thought
|Is all this exposure to the internet worthwhile?
|attached to Database Error Exposes Sensitive Information On 1,700 Kids
|False security
|attached to Airport Experiment Shows That People Recklessly Connect To Any Free Wi-Fi Spot
|Another genie in a bottle.
|attached to Debating a Ban On Autonomous Weapons
|Re:Lawyers are Going to Love This!
|attached to Former Mozilla CEO Launches Security-Centric Browser Brave
|Re:Don't forget...
|attached to Ask Slashdot: Good Introductory SW Engineering Projects? (HS Level)
|Re:It makes no sense.
|attached to NASA Picks Winners For 3D-Printed Mars Habitat Design Contest
|Re:cellphones vs guns?
|attached to Nearly One-third of Consumers Would Give Up Their Car Before Their Smartphone
"Today's robots are very primitive, capable of understanding only a few simple instructions such as 'go left', 'go right', and 'build car'." --John Sladek


text:
Denise Nakon wrote:
> Good morning to all. I am sitting here wondering why I am not being
> allowed to rejoin Hosta Phoenix. If I remember right, a while back,
> Carolyn Schaffner was whining because no one would let her in on the
> pixlist and she didn't think that was right. I'd like to ask her if
> it's 'right' to keep selected people off the Phoenix.
> Denise Nakon
Hi Denise
I take care of a robin and they actually just run themsleves if you let
them. No need to restrict who is on them or not.
Bob Bob Axmear 208 2nd St Ne Waukon, Ia 52172
Hostasonline http://hostasonline.com/
Gardensights Websites http://gardensights.com/
Hosta Library http://hostalibrary.org/
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE HOSTA-OPEN


text:
30 Comments
What adorable pictures, I love your bike! xoAugust 14, 2011 at 6:35 pm
that typewriter is amazing. and the fact that it actually still works! ahhh. every flea market i went to when i was in europe had crazy stuff like this. if only i could've fit five cameras and a typewriter into my backpack.
lovely as usual sgm!August 14, 2011 at 6:36 pm
Obsessed!August 14, 2011 at 6:38 pm
sarah tuckir. i like it!August 14, 2011 at 6:48 pm
You're gorg. The typerwriter is gorg. Mint is my fave. Great post! (:August 14, 2011 at 6:55 pm
LOVE LOVE LOVE the typewriter*
what a beautiful type writer!!! biking looks like so much fun in Europe!August 14, 2011 at 7:06 pm
Woahh! That's a fancy typewriter, it has red AND black ink!? Amazing! haha seriously!
Such cute photos! That salad sounds really good by the way.
Love the typewriter!August 14, 2011 at 7:32 pm
We have an old typewriter in our office that I will occassionally use. It makes typing so much fun! 🙂August 14, 2011 at 7:48 pm
Oh goodness! That typewriter is amazing! Great find!August 14, 2011 at 7:59 pm
WOW – you are such a superstar! typewriter is the best. salad is the best. and nerd glasses pics with you is the best. 🙂August 14, 2011 at 8:56 pm
The outfit is the best…the Kslade clutch and riding hat really sent it over the top for me (c: And I'm on such a mint green kick, this made my day!August 14, 2011 at 10:54 pm
I LOVE that typewriter, and cutest outfit, you look adorable!August 14, 2011 at 11:32 pm
CUTE outfit, love the red lipstick and the typewriter A-mazing.
http://mybeatboutique.blogspot.com/August 14, 2011 at 11:59 pm
you girls are just too cute! and that hearts of palm salad? yum!!!!August 15, 2011 at 1:01 am
Love the new spelling,, 😉 whats even better is that it still works great!! Awesome find!!
The first picture of you is absolutely stunning! Girl, you are gorg!!
xoxoAugust 15, 2011 at 1:11 am
You are so stinkin cute:-) Fun weekend! Pssst I follow your twitter and pinboards now, so excited!August 15, 2011 at 1:42 am
That typewriter is fantastic & I LOVE your bicycle!
Only 20 Swiss Francs? Lucky girl!
So obviously you didn't go to Street Parade in Zürich 🙂 (me neither)
as already said on twitter, i love love love this typewriter! i might consider me even a bit jealous 🙂 and the fact that it only costs 20 CHF is the best! can you believe this? 20 chf? in switzerland?? 🙂August 15, 2011 at 8:58 am
cute! and i love the different ink colors on the type writer. did not know that was a possibility. 🙂August 15, 2011 at 11:12 am
i am officially jealous of your typewriter.August 15, 2011 at 12:57 pm
How cute Sarah!! I'm in LOVE with that typewriter!! What a great find! 🙂August 15, 2011 at 1:01 pm
Obsessed with your typewriter! I now have this weird temtation to search high and low for fun looking typewriters! – AlyssaAugust 15, 2011 at 2:56 pm
i just love that you ride your bike in an actual riding helmet! the cutest. looks just like mine that i used to show in back in my day 🙂
also, i don't even know where to start on the amazingness of that typewriter. you lucky little gal, you.August 15, 2011 at 4:43 pm
the typewriter is so fun! eeee! 🙂August 15, 2011 at 6:02 pm
Just found your blog! LOVE! And that first photo? Gorg!August 18, 2011 at 2:29 pm
The vintage typewriter is adorable. I have always wanted one and hope to get one when we move into our new house 🙂 xAugust 21, 2011 at 7:56 am
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Is San Miguel incorrect or missing key business information? Update your Hotfrog listing today.
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Hotfrog Philippines provides information regarding San Miguel in Pasig Metro Manila. San Miguel is located at San Migual Avenue 9/F, San Miguel Properties Building, Pasig Metro Manila and provides Retail services. Contact them on (02) 637 6385.
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Do i need to do something with some lump called pnames or can i just add a regular lump called (for example) texture1 and put a graphic in it and use it ?
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.. or can i just add ... a graphic in it and use it ?
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Activating mutations in KRAS are the most common oncogenic mutations in human cancers, present in virtually 100% of pancreatic cancers, in 30% of lung cancers, as well as in a variety of other malignancies. One approach to treating such cancers may be to target biochemical-signaling pathways that are regulated by KRAS. Notably, the PI3K and MEK signaling pathways are regulated by KRAS and specific drugs against these pathways have been developed and have shown efficacy against KRAS mutant tumors in mouse models. As these agents are introduced into clinical practice, it will be important to have detection methods to track pathway activity. We propose to identify novel molecular markers and develop imaging probes to detect the activity state of KRAS and its surrogate pathways in vivo. The overall goal of this proposal is to identify novel molecular markers and develop imaging probes that will provide rational approaches to stratify patients for specific treatments and serve as response biomarkers or "surrogates" for new targeted therapies. Our group has been actively involved in the development of techniques and molecular imaging agents that enable earlier detection of primary cancer, metastatic spread, and early evaluation of therapeutic efficacy by molecular imaging. We have also developed genetically engineered mouse models and primary human xenograft systems for preclinical early detection and therapeutic studies. In an extension of our previous work, we will use previously optimized phage display technology, proteomics methods, and conjugation chemistry to 1) screen against known and novel cell surface markers of PI3K and MEK signaling, 2) conjugate lead peptides from these screens to clinically viable magnetofluorescent nanoparticles in order to develop targeted imaging agents against biomarkers of PI3K and MEK, and 3) test the novel imaging agents in vivo using human xenografts. These agents would find immediate application in clinical trials, providing rational criteria for patient selection and for drug dosing and scheduling, and serving as early markers of therapeutic efficacy.
The overall goal of this proposal is to develop new imaging approaches for the detection of KRAS and its surrogate signal transduction pathways in vivo. We will do this by utilizing recently developed mouse models that recapitulate the genetics of human disease. Sophisticated chemical biology approaches will be used to find novel tags that will allow us to pinpoint levels of KRAS activity in tumors and also determine whether a drug against these pathways is effective. We hope to use these tags in conjunction with commonly used imaging approaches such as MRI or endoscopic detection.
|Burd, Christin E; Sorrentino, Jessica A; Clark, Kelly S et al. (2013) Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell 152:340-51
|Shin, Soo J; Beech, Jaymes R; Kelly, Kimberly A (2013) Targeted nanoparticles in imaging: paving the way for personalized medicine in the battle against cancer. Integr Biol (Camb) 5:29-42
|Beech, Jaymes R; Shin, Soo J; Smith, Jeffrey A et al. (2013) Mechanisms for targeted delivery of nanoparticles in cancer. Curr Pharm Des 19:6560-74
|Thomas, Stephanie; Waterman, Peter; Chen, Suelin et al. (2011) Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer. J Nanomed Nanotechnol 2:
|Reynolds, Fred; Panneer, Nivedha; Tutino, Christopher M et al. (2011) A functional proteomic method for biomarker discovery. PLoS One 6:e22471
|Bausch, Dirk; Thomas, Stephanie; Mino-Kenudson, Mari et al. (2011) Plectin-1 as a novel biomarker for pancreatic cancer. Clin Cancer Res 17:302-9
|Seaman, Marc E; Contino, Gianmarco; Bardeesy, Nabeel et al. (2010) Molecular imaging agents: impact on diagnosis and therapeutics in oncology. Expert Rev Mol Med 12:e20


text:
Stretched Burlap Canvas for Wall Art: 12 x 12 inches
Product ID : 977-1212
This 12x12 inch stretched burlap canvas is ready for creating custom burlap wall art, seasonal decor, and more.
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Product Type : Burlap Canvas
Our Price: $5.97
1 burlap canvas per package.


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wedding planner
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Eligible subrecipients include private for-profit intercity bus firms, private non-profit agencies, and public agencies. Applicants should have demonstrable experience in intercity bus operations.
Eligible activities include operating assistance for new, expansion, or continuation of intercity bus services.
MassDOT will be holding a workshop for potential applicants on preparing a successful 5311(f) application and applying for the in-kind local match.
Workshop date and time: August 2, 2016 at 1:00pm. EDT
Workshop location: 10 Park Plaza, Suite 4160 - MassDOT Rail and Transit Division
The deadline for submitting an application is Monday, August 22 at 11:59pm.
Award decisions will be announced on August 31, 2016.
If you have any problems or have questions, please contact Abril Novoa Camino at (857) 368-8968.
Download the Section 5311(f) Fiscal Year 2017 Application
Download the Section 5311(f) Worksheets
Completed applications can be submitted via email to firstname.lastname@example.com, or by mail to:
Abril Novoa Camino
Transit Program Coordinator
MassDOT – Rail and Transit Division
State Transportation Building
10 Park Plaza, Suite 4160
The Massachusetts Department of Transportation (MassDOT) Community Transit Grant Program is an annual competitive grant application process administered by the Rail & Transit Division (RTD) of MassDOT. The application process typically begins in mid-January or early February with six applicant training sessions, followed by a one-month open application period during the month of February. Please consult the posted schedule for dates and deadlines. Applicants that are selected for awards are usually notified around the first week of April.
View the schedule for the State Fiscal Year 2017 Grant Application Trainings
The Federal Transit Administration (FTA) provides financial assistance to states through a number of programs to develop new transit systems and improve, maintain, and operate existing systems. The Governor of the Commonwealth of Massachusetts has designated the MassDOT as the agency of authority and responsibility for administering assistance received in Massachusetts through Title 49 USC Sections 5310, and 5339 (Small-Urban & Statewide portions only) funding programs.
The Commonwealth of Massachusetts through RTD within MassDOT, provides financial assistance to eligible organizations through several programs to provide a state financial match to federally funded capital, operating, and planning projects. RTD distributes financial assistance through the Mobility Assistance Program (MAP) to provide transportation services to elderly persons and persons with disabilities as defined in Chapter 637 Sec. 13 of the Acts of 1983.
Application Availability: The state fiscal year 2017 application period will open on January 25, 2016.
Application Due Date: All applications must be received by MassDOT no later than 5 p.m. on February 22, 2016.
Applicants must use MassDOT's online grant application system, GrantsPlus, to submit applications. Applicants are encouraged to submit applications before the deadline. Applications received after the deadline will not be considered.
Any questions should be directed to Jillian Linnell, at firstname.lastname@example.com or by phone at 857-368-8584.
We look forward to your application submission.


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Interactive Chemical Reactions PowerPoint
Reviewed by members of Editorial board for inclusion in MERLOT.Editor ReviewVery good quality; in queue to be peer reviewedavg:
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Chris Hren (Teacher (K-12))
First let me say that I think trying to address chemical reactions in this StAIR is a very admirable task due to the complicated nature of them and the difficulty addressing some of the questions students sometimes have. With that said, I think you did a very good job in doing just that. There is so much that goes into reactions and I believe you did a great job of trying to cover all of that information throughout the presentation. I liked that you reviewed formula writing and balancing along with the information presented about reactions. In addition, I think choosing only three types of chemical reactions for the StAIR was a good choice and one that made it something you could realistically do. I know that once you get into single and double displacement reactions the amount of things that must be dealt with increases dramatically and in truth I don't believe those could be covered in something like this without spending an unbelievable amount of time designing it. So in short, I think this is just right.
However, there are a few things I would have changed to make the presentation flow a bit better. First, I thought there were too many animations throughout the presentation. I realize that this might be my own personal opinion but sometimes I just want to see the text and move on. I feel sometimes that people, myself included, feel the need to animate everything that shows up on a powerpoint slide when in truth sometimes that animation just slows the thing down. Another suggestion I have is the same thing I said for Tammie's, which is to perhaps include some sort of audio track explaining the written text. I realize this adds an entirely new layer of work to the activity but I believe it might have helped for certain points with students who learn better audibly.
Overall though, I think it is a really great presentation!
Technical Remarks:
I only have two small technical aspects that I might take issue with. The first is that this PowerPoint ran really slowly on my computer throughout. I think that was due to the animations and PowerPoint being what it is. I know it was not my computer as it is quite powerful. I say this because I know most school computers do not have anywhere near the processing power of this thing and they might run the presentation even slower. They might have no problem though, it is just a thought. In addition, perhaps having the presentation begin automatically as soon as you open it would be a good idea. It would prevent the user from accidently clicking or doing something that messes it up before they begin the slideshow.
Tammie Mirolli (Teacher (K-12))
First, I think the topic is one students often struggle with. Reactions, whether it's identifying the type of reaction or predicting products is one of the most difficult topics for students.
I like the various examples for students practice, and I think the quiz is an excellent way for students to check their understanding. Have you thought about expanding this to include all the reaction types that you teach? This would be a great way to introduce the topic and then another way for students to review with later.
All your fonts and colors are easy to read and very clear. I didn't hear any sound. Was this intentional? I think some sounds, not too many, would help keep students engaged and interested in the tutorial.
I think having the objectives present is great. This really helps students recognize what they will be learning and expected to know and do once they are finished.
Your visuals are colorful and are excellent ways for students to connect concepts to meaning. I like how you used the dots to represent reactants and products. Using colors that when combined create a new color is genius. Students know when you mix blue and yellow, green is produced. So that is an alternate way of helping them connect their prior knowledge to new concepts when building understanding.
Technical Remarks:
One remark, not sure if it would be technical or just a regular comment, but I think there maybe too many transiitions on the slides or the transitions may need to be sped up a bit. I felt I was waiting a while for the information to come on the screen. This many transitions may be a bit distracting. But again that might be a personal preference.


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Telephone & Addresses
Anand C Kadam (Age: 76)
95148 San Jose CA
Anand C Kadam, 77, San Jose, Alder Creek Ct
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Nady GEQ 131 Single 31-Band EQ
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I got this several months ago and have used it to record several songs. It does what it's supposed to. It doesn't look like the picture shown. It also doesn't have RCA plugs like the description says. But it may have been the one I got. Anyway, for what it's supposed to, it works great.
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Cytosine arabinoside (Ara-C) is the single most effective drug used in the treatment of acute myelogenous leukemia (AML). However, Ara-C efficacy and toxicity vary widely among patients with this disease. Therefore, we propose to study the pharmacogenomics of Ara-C. Pharmacogenomics is the study of the role of inheritance in individual variation in drug response phenotypes. The proposed Ara-C pharmacogenomic studies will utilize a data-rich cell-based ?model system? consisting of 200 Coriell Institute Human Variation Panel lymphoblastoid cell lines. We have already used these cell lines to obtain indepth resequencing data for genes encoding proteins involved in Ara-C transport, metabolism, activation and targets (the ?Ara-C pathway?);to assay genome-wide single nucleotide polymorphisms (SNPs) for use in genome-wide association studies;and to generate basal expression array data. We now propose to assess Ara-C drug response phenotypes in the same cell lines, including cytotoxicity, assays of active drug metabolites and expression array data after Ara-C exposure to make it possible to perform genotype- phenotype correlation analyses to identify genomic markers associated with Ara-C response. Genes that display genotype-phenotype correlations will also be studied functionally. Pharmacogenomic hypotheses generated with Human Variation Panel cell line will then be tested with DNA samples obtained from over 700 AML patients who were treated with Ara-C. The results of these studies will increase our understanding of the contribution of inheritance to individual variation in Ara-C efficacy and toxicity, and will help us to move toward the goal of ?individualized? therapy with this important antineoplastic drug used in the treatment of AML. NARRATIVE Acute myelogenous leukemia (AML) is a major blood cancer in adults, and cytosine arabinoside (Ara-C) is the most effective single drug used to treat this form of cancer. However, there are large differences among patients in both Ara-C therapeutic effect and toxicity. The proposed studies will use a novel ?Human Variation Panel? of over 200 immortalized human cell lines and DNA from AML patients treated with Ara-C to identify ?pharmacogenomic? factors involved in the effects of inheritance on variation in response to Ara- C therapy to make it possible to better ?individualize? therapy of AML with Ara-C.
|Wang, Liewei; Weinshilboum, Richard (2014) Metformin pharmacogenomics: biomarkers to mechanisms. Diabetes 63:2609-10
|Monte, Andrew A; Heard, Kennon J; Campbell, Jenny et al. (2014) The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. Acad Emerg Med 21:879-85
|Matimba, Alice; Li, Fang; Livshits, Alina et al. (2014) Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes. Pharmacogenomics 15:433-47
|Laurie, Cathy C; Laurie, Cecelia A; Smoley, Stephanie A et al. (2014) Acquired chromosomal anomalies in chronic lymphocytic leukemia patients compared with more than 50,000 quasi-normal participants. Cancer Genet 207:19-30
|Pereira, Naveen L; Lin, Dong; Pelleymounter, Linda et al. (2013) Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation. Circ Cardiovasc Genet 6:201-10
|Ellsworth, Katarzyna A; Moon, Irene; Eckloff, Bruce W et al. (2013) FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder. Pharmacogenet Genomics 23:156-66
|Appell, Malin L; Berg, Jonathan; Duley, John et al. (2013) Nomenclature for alleles of the thiopurine methyltransferase gene. Pharmacogenet Genomics 23:242-8
|Farrugia, G; Weinshilboum, R M (2013) Challenges in implementing genomic medicine: the Mayo Clinic Center for Individualized Medicine. Clin Pharmacol Ther 94:204-6
|Liang, Jackson J; Geske, Jennifer R; Boilson, Barry A et al. (2013) TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation. Pharmacogenet Genomics 23:658-65
|Abo, Ryan; Hebbring, Scott; Ji, Yuan et al. (2012) Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics. Pharmacogenet Genomics 22:247-53
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100 Tech Tips, #95 IBM InfoSphere Streams: Assembling Continuous Insight in the Information Revolution draft is now available
wbratton Tags: streams im_resource data infosphere analytic rtap big redbook 3,087 Views
100 Tech Tips, #95 IBM InfoSphere Streams RedBook titled Assembling Continuous Insight in the Information Revolution draft is now available . This IBM® Redbooks® publication discusses and describes the positioning, functions, capabilities, and advanced...
from Blog: Thoughts from Support
5 Things to Know About IBM Intelligent Operations Center Services API
MarcelaAdanRochester Tags: intelligent_operations_ce... ravichandran ioc ibm smarter_cities redbooks jayashree_ravichandran redbook 1 Comment 7,908 Views
IBM® Intelligent Operations Center provides an executive dashboard to help city leaders gain insight into various aspects of city management. IBM Intelligent Operations Center is an integrated solution; it provides a rich set of capabilities that can be...
from Blog: 5 Things To Know IBM Redbooks BlogModified on by MarcelaAdanRochester
5 Things to Know About New and Enhanced Capabilities in IBM Intelligent Operations Center V1.6
MarcelaAdanRochester Tags: redbook redbooks smarter_cities ibm_intelligent_operation... marcela_adan ioc adan 4,229 Views
Today's environment presents many significant challenges for city leaders. It's mind boggling the vast amounts of data (both structured and unstructured) that exist within cities. Lack of visibility inhibits the delivery of an optimal response...
from Blog: 5 Things To Know IBM Redbooks BlogModified on by MarcelaAdanRochester
A Minor Fact About Lock Structures
Sometimes reading the SMF manual buys you less than you thought. I had completely ignored a nice little field - and the code I inherited to analyse SMF 74 Subtype 4 Coupling Facility data ignored it as well. R744SLEC in the Request Data Section for a structure...
Achieving compliance with IBM Security zSecure Command Verifier and other security approaches Community Blog
JeroenTiggelman Tags: qradar zsecure iam command_verifier security-intelligence guardium redbook security ibm_systems_magazine 1,719 Views
Earlier this month IBM Systems Magazine published an article by Joel Tilton Using IBM Security zSecure Command Verifier to Achieve Compliance . Note you can also navigate from there to Joel's earlier article...
from Blog: Security on developerWorksModified on by JeroenTiggelman
Active Memory Deduplication Redbook on a Kindle
Seasonal Greeting. My family decided to give me a Kindle e-book - Wow! So after the usual experiments with reading a book, playing with the web browser via WiFi, I then thought; Could this help me at work too! So reading up I noted it fully supports PDF...
from Blog: AIXpert Blog
Announcing the IWA RedBook
Query Acceleration for Business using Informix Warehouse Accelerator A draft IBM Redbooks publication (Planned Published date of November 2013) Abstract IBM Informix Warehouse Accelerator (IWA) is a state-of-the-art in-memory database designed...
from Blog: Fred Ho's BlogModified on by fredho66
Announcing the IWA RedBook!
Query Acceleration for Business using Informix Warehouse Accelerator A draft IBM Redbooks publication (Planned Published date of November 2013) Abstract IBM Informix Warehouse Accelerator (IWA) is a state-of-the-art in-memory database designed...Modified on by Joel_SF
Announcing the "Cloud Enabling CICS" Redbook
Matthew Webster Tags: redbook cloud blog 2,879 Views
Have you been wondering where to get started with CICS applications, platforms and policy? Are you unsure whether the CICS cloud enablement capability in CICS TS V5 applies to your applications or environment? The recently released Cloud Enabling&nbs...
from Blog: CICSdev CommunityModified on by Matthew Webster
Any feedback on CICS TS for z/VSE book ? Next blog entry on Monday (Feb.20)
Ingolf24 Tags: documentation redbook vse cics 309 Views
We are preparing a new CICS TS for z/VSE IBM Redbook. It's still a draft, no date yet. I added the table of contents below. Does the content look OK ? Is there anything missing ? What else would you expect / propose ? I plan the next blog entry for...
Aprenda a usar Rational Software Architect - RSA
academicbr Tags: redbook oportunidades java websphere rsa developer eclipse emprego 6,349 Views
Hoje vamos mostrar como usar o RSA para desenvolvimento de Software . Antes explicaremos a ferramenta. Com RSA é possível unir modelagem + code clear de maneira bem simples. O desenvolvedor não gasta tempo modelando e depois codificando. A própria ferramenta...
from Blog: blog do Academic Initiative IBM
Are you looking for an introduction to the mainframe ?
There is more and more interest in publications that can be used by students or professionals starting on the mainframe. A good introduction to the mainframe and its operating systems provide our IBM Redbooks. I would start with the "Introduction to the...
Are you using the CICS Transaction Gateway ? ... and a new IBM Redbook
I would like to have some information on how you connect to the CICS Transaction Server on z/VSE (CICS TS). Do you use the CICS Transaction Gateway (CTG) ? Do you connect via SNA or TCP/IP ? See also my CTG blog entry for more information on the CTG....
Back From Vacation And Raring To Go - To Poughkeepsie
MartinPacker Tags: redbook residency batch 3,372 Views
Usually when I go away on holiday I bring something back with me. Often in the form of fresh ideas. This year it's been such a hectic one that all I did was to flake out. So no new ideas this time. Perhaps that's a good thing, perhaps not. But I think I did...
Bridging the business and technical perceptions of enterprise security Community Blog
Kane Scarlett Tags: ibm-security ibm_security_blueprint security redbook ibm_security_framework 1,885 Views
From IBM Redbooks, Using the IBM Security Framework and IBM Security Blueprint to Realize Business-Driven Security can help organizations effectively visualize security issues by creating a bridge to address the communication gap between the business and...
from Blog: Security on developerWorksModified on by Kane Scarlett
Cache Structure Information
It's fair to say I've written very little in terms of book words these past two days. That's because I've been "doing research" on how the cache structure counters really work. "Doing research" is a euphemism for "finding out how the heck the darned thing...
DB2 10 Redbook, "Unleashing DB2 10 for Linux, UNIX, and Windows"
Just released: " Unleashing DB2 10 for Linux, UNIX, and Windows ", and available for downloading in either PDF format or EPUB format for use on ebook readers. Authors: Danny Arnold Steve Diniro Vivian Lee Stan Musker Jo-Ann Woods Abstract: This...
from Blog: Keep on Learning
DB2 Virtualization
svisser1 Tags: redbook virtualization vmware db2 whitepaper 4,313 Views
Faced with the challenge of reduced IT budgets and an increased need for new information systems to help improve operational efficiency and competitiveness, IT administrators adopt virtualization technologies to optimize their IT infrastructure. IBM DB2 for...
from Blog: Keep on Learning
Did you see that latest IBM Redbook blog entry about z13 I/O ?
The IBM Redbook blog " 5 things to know " shares five interesting things about one of the IBM's products or services. One of the last blog entries may be of interest for you: 5 Things to Know about IBM z13's I/O Enhancements ....
Do you know our z/VSE Redbooks ?
You may be interested in our IBM Redbooks addressing z/VSE topics: Introduction to the New Mainframe: z/VSE Basics provides some basic information of the mainframe and a high level overview of the z/VSE operating system, its products, components and...
Do you like IBM Redbooks ?
If I have a specific topic related to operating systems, I always check our IBM Redbook pages, if there is any information available related to that. In many cases I find what I am looking for. In the past I always downloaded the pdf version of the document....
Do you still use SNA Networking in your z/VSE environment ?
The last weeks I got questions about SNA (Systems Network Architecture). May be you are also interested in that topic. The questions are related to the following products: 5648-063 IBM Advanced Communication Function/Network Control Program...
Do you use batch processing on the z/OS platform? Checkout this brand new IBM Redbook! Community Blog
Mainframe computers play a central role in the daily operations of many of the world's largest corporations, and batch processing is a fundamental part of the workloads that run on the mainframe. Do you want a book that specifically addresses batch...
from Blog: System z Management
Do you want to learn more about IBM Tivoli Storage Productivity Center for Replication in an open systems environment? Community Blog
bobby_g Tags: storage open systems ibm_storage productivity redbook replication 3,858 Views
Well, its your lucky day! See the newly published IBM Redbook, Tivoli Storage Productivity Center for Replication for Open Systems . This publication is full of handy tips and excellent guidance for session usage, tunable parameters, troubleshooting,...
from Blog: Storage ManagementModified on by bobby_g
Draft Redbook - Embedding IDS: An Introduction
gbowerman Tags: embeddability redbook 3,390 Views
A new IBM Redbook has been just been made available in draft form. Entitled Embedding Informix Dynamic Server: An Introduction , the book covers IDS features that make it suitable for embedding, and methods and techniques for embedding IDS into applications...
from Blog: Administrating and Developing with Informix


text:
Japan's Post-Disaster Dysfunction
You would expect a nation famed for its efficiency and infrastructure to set the world standard for rebuilding. One year after a giant earthquake and tsunami, Japan's revival has barely begun. In the days after March 11, economists predicted a powerful rebound as construction crews converged on the earthquake-ravaged northeastern Tohoku region, a replay of what happened following the Kobe temblor in 1995. What's more, many hoped the disaster—20,000 dead, towns wiped out, the worst nuclear crisis since Chernobyl—would break Tokyo's political paralysis and catalyze major change.
Politicians have spent the two-plus decades since Japan's bubble burst doubling down on the strategies of the past: massive borrowing to finance public works, ultra-low interest rates, lifetime employment, negligible immigration, a rigid industrial structure favoring exports from a handful of behemoths, compliant banks, and clubby ties between the political and business worlds. Incestuous links between bureaucrats and management at Tokyo Electric Power enabled years of doctored safety reports and underestimated risks. This set the stage for Japan's nuclear crisis, which is still unfolding; radiation continues to leak out of the Fukushima nuclear plant and serves as a daily symbol of Japanese dysfunction.
It's long been said that only a huge crisis would nudge Japan onto a more productive course, as occurred following the devastation of World War II. Instead, plans to spend about ¥20 trillion ($250 billion) on reconstruction have been stymied by Prime Minister Yoshihiko Noda's failure to articulate a grand vision, bureaucrats' reluctance to make vital decisions, and the realities of the deflationary cycle that deepened over the last 12 months and depressed both companies and consumers. Japan's new Reconstruction Agency only began operations on Feb. 10, 11 months after the tsunami.
"They have done a great job of neatly piling the debris and tucking it under tarps, but otherwise I see little progress," says Jeff Kingston, head of the Asian Studies program at Temple University's Tokyo Campus. "Partly it's political paralysis and partly bureaucratic indecision about what to rebuild, how to consolidate, and the problem of disposing of that rubbish."
The wreckage that's getting the most attention is Japan's economy. The public debt, long the world's largest, is more than double the size of its $5.5 trillion economy. Gross domestic product contracted in three of the previous four quarters, the current account surplus shrank in 2011 to a 15-year low, and Japan posted a record ¥1.48 trillion trade deficit in January. The strong yen slammed exporters such as Sony and Honda Motor, hollowing out the industrial sector further. "The government simply didn't come through, and that hasn't been lost on the Japanese people," says Gerard Lyons, London-based chief economist at Standard Chartered Bank.
With distrust growing, the prime minister's days appear numbered. In September, Noda, 54, rode to power on a wave of popular support—the right no-nonsense leader at the right moment, not only to rebuild the economy but also reinvent it. Now voters have come to believe he's no more the man for the job than the five other prime ministers since late 2006. His approval rating is 30 percent, the point at which lawmakers called for his predecessors to go.
With or without Noda, decisions must be made about nationalizing Tepco and firing its top management, whose negligence helped put Japan where it is today. The same goes for taking on the culture that produced the embarrassing accounting scandal at Olympus.
Japan's prime minister must create a mechanism to decide which towns and villages in Tohoku will be restored and which won't be. Much of rural Japan has been losing its population and industrial strength for years.
Decentralizing power, which would require a regulatory revolution in the central government, would help the process. Japan has long been a top-down economy: Tokyo bureaucrats call the shots and divvy up the tax revenues; local leaders react accordingly. Those in Tokyo working on revival plans are mired in red tape and too far away from the damaged areas to grasp the complexities of life there. Japan's depopulated towns need to join forces and share budgets—a move Tokyo is too busy and distracted to make. The biggest mistake would be for Japan to try to recreate what existed on March 10, 2011. Despite what has been a lost year for Japan, the nation still has an opportunity for the kind of reset that doesn't come along often. It would be a shame if Japan wasted it.


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Helen Van Pelt Wilson in her book "The Joy of Geraniums", which was published
in the early seventies, lists the following:
crispum, Gooseberry leaved.
slightly pungent; crispum-like leaves, some yellow marked; compact plant;
free-flowering lavender, cerise feathering on upper petals.
You might find her book in your local library. The book has been out of print
for several years. It has a lot of good information on Geraniums and


text:
Eggplant Supper Soup
|Olive oil/Salad oil
|2 Tablespoon
|2 Tablespoon
|1 Medium, chopped
|Lean ground beef
|1 Pound
|1 Medium, diced
|1 Clove (5 gm), minced or mashed
|Chopped carrot
|1⁄2 Cup (8 tbs)
|Sliced celery
|1⁄2 Cup (8 tbs)
|Canned pear shaped tomatoes
|1 3⁄4 Pound (1 Pound And 12 Ounce Can)
|Canned beef broth
|28 Ounce (Two 14 Ounce Cans)
|1 Teaspoon
|1 Teaspoon
|1⁄2 Teaspoon
|1⁄2 Teaspoon
|Salad macaroni
|1⁄2 Cup (8 tbs)
|Minced parsley
|2 Tablespoon
|Grated parmesan cheese
|1 Tablespoon
Heat the salad oil and butter in a large pan or Dutch oven, add the onion, and saute until limp, about 3 minutes.
Add the meat and stir over the heat until it loses its pinkness.
Add the eggplant, garlic, carrots, celery, tomatoes (break up tomatoes with a fork), beef broth, salt, sugar, pepper, and nutmeg.
Cover and simmer for about 30 minutes.
Add the macaroni and parsley and simmer about 10 minutes more, or until macaroni is tender.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 2037 Calories from Fat 898
% Daily Value*
Total Fat 102 g156.6%
Saturated Fat 38.4 g192.2%
Trans Fat 0 g
Cholesterol 337.7 mg112.6%
Sodium 6237.2 mg259.9%
Total Carbohydrates 158 g52.7%
Dietary Fiber 36.7 g146.9%
Sugars 28.8 g
Protein 136 g271.3%
Vitamin A 399.1% Vitamin C 238.6%
Calcium 68.3% Iron 141.4%
*Based on a 2000 Calorie diet


text:
Quality Hotel Excel Roma Ciampino
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Travel Blogs from Marino
100 kms to go
For our 1000km trip total km goal, that is. Apparently its about 50 kms roughly to Anagni from here, but we still have to navigate a good route, meaning quietish back roads, to get there. And then we'll need to do a little sightseeing loop on Tuesday in order to complete it. We enjoyed our last special breakfast buffet this morning, and then …
Oh pope, where art thou?
... many people. We eventually found an English speaking Italian, who told us the pope was having a meeting with the school children today, and that's why we couldn't get closer. He was going to be having the meeting at 4pm. With that information, we trotted off to explore some rome streets as we hadn't seen very many yet! We walked past lots of little restaurants, ice cream shops and generally just explored! We went to ...
Day 17 - Rome
... and dramas based on Classical mythology. The building ceased to be used for entertainment in the early medieval era. It was later reused for such purposes as housing, workshops, quarters for a religious order, a fortress, a quarry, and a Christian shrine. Although in the 21st century it stays partially ruined because of damage caused by devastating earthquakes and stone-robbers, the Colosseum is an iconic symbol of Imperial Rome. It is one of Rome's most popular tourist attractions ...
Best Vatican Tour Ever!
... commissioned by Pope Julius II. The various elements include the Creation of Adam and nine scenes from the book of Genesis. On the back wall is the large fresco of The Last Judgement done almost 30 years later from 1536-1541.
Chiara points out a small wooden door on the wall opposite the Last Judgment and explains that through that small door is the place where the ballots are burned during a Papal election.
We exit the ...
Day 22 - Vatican City and a little more Roma
... commissioned to do a sculpture for a church that the architect of that church did not want him involved in it as the church would become more about the sculpture than his architecture. He therefore convinced the pope to get Michelangelo to paint the Sistine Chapel. Michelangelo initially refused and went to Florence in a huff insulted to have been asked to do this, he was after all a sculpture not a painter. The pope sent someone to chase Michelangelo up and make him an ...


text:
Aim 1: Provide Scientific Leadership: Scientific decision-making is the responsibility of the Project Director/Principle Investigator after consultation with the Project/Core leaders and discussion at our regular meetings linked with consensus building. The administrative Core will also be the interface and will seek guidance from the Internal and External Advisory Committees Aim 2: Communication/Conferences: The key role of the Administrative Core is to establish efficient communication as it relates to the dissemination of scientific data/discoveries. Our success will be dependent on the active and open communication process between the members of the POl at all levels. The Administrative Core will pursue an active interaction with the Internal and External Advisory Committees and NIH and the office of Sponsored Programs itself. At specific intervals we will have a "Strategic Meeting" to set the direction for the next Quarter and plan for the Internal and External Advisors visits. The administrative Core will also coordinate the preparation of the progress reports for NIH prior to the joint External/Internal Advisory Committee meetings.
Aim 3 : Budget Management: Oversee the financial and conduct of the overall POl. Projects leaders will have responsibility for managing their individual budgets, with summaries provided by Core A. Core A will prepare budget summaries for presentation to the Pi's and Core directors.
Aim 4 : IRB/IACUC/Safety: Helping with Animals and Human Subjects, and Safety Committees re-approval.
The Administrative Core will continue provide leadership for the smooth conduct of the 3 projects and 2 cores. This includes facilitating proper communication within the PPG and with NIH and the University in general. To this end the model we have adhered to for the past 10 years has many proven strengths as demonstrated by the outstanding productivity of the POl to date. Division of Reproductive Sciences and our department have synergized with an excellent group of established scientists to ensure outstanding success.
|Boeldt, Derek S; Hankes, Amanda C; Alvarez, Roxanne E et al. (2014) Pregnancy programming and preeclampsia: identifying a human endothelial model to study pregnancy-adapted endothelial function and endothelial adaptive failure in preeclamptic subjects. Adv Exp Med Biol 814:27-47
|Zhao, Ying-Jie; Zou, Qing-Yun; Li, Yan et al. (2014) Expression of G-protein subunit ?-14 is increased in human placentas from preeclamptic pregnancies. J Histochem Cytochem 62:347-54
|Jiang, Yi-Zhou; Li, Yan; Wang, Kai et al. (2014) Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen. Mol Cell Endocrinol 391:60-7
|Li, Hui-Hui; Zhao, Ying-Jie; Li, Yan et al. (2014) Estradiol 17? and its metabolites stimulate cell proliferation and antagonize ascorbic acid-suppressed cell proliferation in human ovarian cancer cells. Reprod Sci 21:102-11
|Chen, Dong-Bao; Zheng, Jing (2014) Regulation of placental angiogenesis. Microcirculation 21:15-25
|Ampey, Bryan C; Morschauser, Timothy J; Lampe, Paul D et al. (2014) Gap junction regulation of vascular tone: implications of modulatory intercellular communication during gestation. Adv Exp Med Biol 814:117-32
|Boeldt, Derek S; Grummer, Mary A; Magness, Ronald R et al. (2014) Altered VEGF-stimulated Ca2+ signaling in part underlies pregnancy-adapted eNOS activity in UAEC. J Endocrinol 223:1-11
|Schreier, David A; Hacker, Timothy A; Hunter, Kendall et al. (2014) Impact of increased hematocrit on right ventricular afterload in response to chronic hypoxia. J Appl Physiol (1985) 117:833-9
|Morschauser, Timothy J; Ramadoss, Jayanth; Koch, Jill M et al. (2014) Local effects of pregnancy on connexin proteins that mediate Ca2+-associated uterine endothelial NO synthesis. Hypertension 63:589-94
|Giakoumopoulos, M; Golos, T G (2013) Embryonic stem cell-derived trophoblast differentiation: a comparative review of the biology, function, and signaling mechanisms. J Endocrinol 216:R33-45
Showing the most recent 10 out of 53 publications


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Ron brings to your counselling process significant cross-cultural experience, a love of learning, and life with a "challenged" child. Front and centre of counselling are the concerns which bring you in to counselling. The goals which you work out together with Ron are constantly on the horizon of your time together.
Cross-culturally, Ron has been married into the Chinese culture (with his Hong Kong born wife, Sarah) for over twenty years. In their early years of marriage, he and his wife were missionaries for eight years, as Ron taught initially in Hong Kong, and then for five years in Zimbabwe, Africa. During this time his doctoral training was in yet another cultural context, South Africa. Responsibilities at the Theological College of Zimbabwe included being the Dean of Students, a role which he thoroughly loved doing, mediating between the largely white faculty and the mostly black student body. Returning to Canada was in itself a cultural experience, since 'living abroad' had dislocated his own cultural moorings, and--as often happens to such nomads--he is thus more sensitized to the uprootedness and varieties of cultural experience.
Your counselling with Ron is served well by his unending love of learning. At the master level (MDiv, ThM) Ron specialized in two areas: counselling, and biblical studies. He taught for many years at the university level in biblical studies before returning to the world of therapy. Counselling and Proverbs were the focus of his doctoral studies (DD, at the University of Pretoria). Ron remains committed to the endless task of learning in a number of interrelated areas, blending theory with practicality.
Life is challenging enough, but having a son diagnosed initially as having Attention Deficit Disorder, a diagnosis later changed to Asperger Syndrome (a type of Autism), certainly added to the challenge of family life. Years of learning about these conditions have helped sensitize Ron to how these can add to the challenges of family life. His son is now doing well at university, with dreams of 'places to go and things to do' after graduation. Ron is delighted to help families navigate the cross-currents of such challenges.
During his years as parent-about-the-house Ron managed to complete a book on marriage, entitled Beyond Survival: Marriage and the Quest for Paradise (2005). He was also a contributor to the Canadian bestseller Hot Apple Cider (2008).
Ron knows the challenge of putting the complexity of relationships, and things deeply felt, into words. That's why he constantly checks in with you about how we're progressing towards meeting your concerns. Counselling can bring both healing and growth into our lives as we work through life's challenges. Contact Ron to see how you can work together with him on meeting your concerns.
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Volume 852 of the series Lecture Notes in Computer Science pp 509-528
Ring-banyan network: A fault tolerant multistage interconnection network and its fault diagnosis
- Jae-Hyun ParkAffiliated withDept. of Computer Science, Korea Advanced Institute of Science and Technology
- , Heung-Kyu LeeAffiliated withDept. of Computer Science, Korea Advanced Institute of Science and Technology
- , Ju-Hyun ChoAffiliated withControl System Section, Electronics and Telecommunications Research Institute
* Final gross prices may vary according to local VAT.Get Access
In this paper. we describe the fault tolerant schemes for the multistage interconnection network (MIN) and its fault diagnosis. Firstly, we present a fault tolerant MIN and a adaptive self-routing scheme for the network. It can provide more multiple paths than the previous networks between an input/output pair of a network by adding extra links between switching elements in the same stage and modifying the self-routing scheme of the regular MIN. The presented routing scheme is as simple as that of the regular MIN, which is based on the topological relationships among the switching elements (SE's) that render a packet to the same destination with the regular self-routing. We present an algebraic proof to show the correctness of the scheme, and an analytic reliability analysis to provide quantitative comparisons with other some networks. Of the special notes is the finding that the network is more cost effective than the regular MIN and other augmented MIN's in terms of the reliability. Secondary. we consider the fault models in the fault detection and the location schemes. We present a new fault diagnosis scheme for the network.
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- Title
- Ring-banyan network: A fault tolerant multistage interconnection network and its fault diagnosis
- Book Title
- Dependable Computing — EDCC-1
- Book Subtitle
- First European Dependable Computing Conference Berlin, Germany, October 4–6, 1994 Proceedings
- Pages
- pp 509-528
- Copyright
- 1994
- 10.1007/3-540-58426-9_155
- Print ISBN
- 978-3-540-58426-1
- Online ISBN
- 978-3-540-48785-2
- Series Title
- Lecture Notes in Computer Science
- Series Volume
- 852
- Series ISSN
- 0302-9743
- Publisher
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag
- Additional Links
- Topics
- Industry Sectors
- eBook Packages
- Editors
- Authors
- Jae-Hyun Park (1)
- Heung-Kyu Lee (1)
- Ju-Hyun Cho (2)
- Author Affiliations
- 1. Dept. of Computer Science, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusung-Ku, 305-701, Taejon, Korea
- 2. Control System Section, Electronics and Telecommunications Research Institute, P.O.Box 8, 305-606, Taejon, Korea
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text:
Potential for Developing Fusidic Acid (TAKSTA, CEM-102) in the U.S. is Profiled in Clinical Infectious Disease
CHAPEL HILL, N.C., June 1, 2011 /PRNewswire/ -- Cempra Pharmaceuticals, a developer of differentiated antibiotics, announced the publication of a Clinical Infectious Disease supplement (Vol. 52, Supplement 7) that profiles fusidic acid and specifically TAKSTA (CEM-102), administered using a proprietary loading dose regimen, for use in treating acute bacterial skin and skin structure infections (ABSSSI) in the U.S.
Articles contributed by experts in infectious disease discuss a range of topics that describe the compound's potent in vitro activity against U.S. strains of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and streptococci, the two most common pathogens associated with ABSSSI. The rationale underlying Cempra's proprietary loading dose regimen is discussed along with its excellent tolerability and pharmacokinetic profile in healthy volunteers in Phase 1 trials. The positive results of a Phase 2 clinical trial, comparing TAKSTA to oral linezolid, in patients with ABSSSI, suggest comparable tolerability and efficacy. A case report of a patient with refractory MRSA-infected chronic osteomyelitis facing amputation treated with oral daily doses of fusidic acid for nine months reinforced the compound's excellent tolerability. The patients infection also improved rapidly during treatment with the drug.
"Fusidic acid has been a valuable antibiotic for treating ABSSSI in many countries outside the U.S. for several decades," said Prabhavathi Fernandes, Ph.D., chief executive officer of Cempra and a contributing author to the supplement. "MRSA infections continue to be a serious problem in the hospital as well as in the community so the need for new agents, particularly orally-administered drugs, is critical. Fusidic acid is a promising candidate to treat ABSSSI infections in the U.S. because of its potency against U.S. MRSA strains and its excellent safety profile. Our proprietary dosing regimen, based on the compound's pharmacokinetic and pharmacodynamic profile, should maximize efficacy while minimizing resistance development. This supplement provides U.S. clinicians and scientists an opportunity to learn more about fusidic acid and its clinical development in the U.S."
About TAKSTA
TAKSTA (sodium fusidate) is a novel class of antibiotic with an established history of safety and efficacy outside the United States. TAKSTA is being developed as an NCE in the U.S. for ABSSSI. Clinical trials with TAKSTA employ a proprietary front-loading oral regimen designed to increase potency, increase coverage and minimize resistance development. Cempra believes that TAKSTA will be an important addition to anti-MRSA therapies based on the following:
- Sodium fusidate is orally active against gram-positive bacteria, including all S. aureus strains such as HA-MRSA and CA-MRSA
- TAKSTA employs a novel and proprietary PK-PD-based dosing regimen of sodium fusidate that optimizes efficacy and minimizes the risk of resistance development
- Sodium fusidate is the only compound within the fusidane class and therefore is unlikely to select for cross-resistance to other classes of antibiotics
- Sodium fusidate's safety has been well documented even when used for long periods of time (over one year) to treat osteomyelitis and other serious infections
- Sodium fusidate has been used safely in children including neonates in countries where it is marketed
About 60 to 80 percent of the 13 million acute skin structure infections that occur in the U.S. each year are infected with MRSA. There is a growing need for an oral anti-MRSA drug that is effective and is safe for long-term administration.
About Cempra PharmaceuticalsFounded in 2006, Cempra Pharmaceuticals is a privately-held, clinical-stage pharmaceutical company focused on developing antibacterials to address critical medical needs. Two lead products, both in late-stage clinical trials, address the urgent and increasing need for new treatments targeting drug-resistant bacterial infections in the hospital and in the community. Cempra is well-funded and is committed to developing commercially and medically differentiated and novel products that reduce development risk and provide a high financial return. The company is also utilizing its proprietary compound library and chemistry technology to develop novel macrolides without antibacterial activity for non-antibiotic uses such as COPD, chronic inflammatory and GI disorders. Additional information about Cempra can be found at www.cempra.com.
Media Contacts: Russo Partners LLCRobert E. Flamm, Ph.D.(212) 845-4226 firstname.lastname@example.com
Tony Russo, Ph.D.(212) email@example.com
SOURCE Cempra Pharmaceuticals Inc.


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New York Times: The largest study ever to ask whether a low-fat diet reduces the risk of getting cancer or heart disease has found that the diet has no effect.
The $415 million federal study involved nearly 49,000 women ages 50 to 79 who were followed for eight years. In the end, those assigned to a low-fat diet had the same rates of breast cancer, colon cancer, heart attacks and strokes as those who ate whatever they pleased, researchers are reporting today. | story or read the reports
Truthdig says: Don't start mainlining lard just yet. The next study is surely just around the corner….


text: Blogs From Science Fair To Felony Charges Category: Chemical Experiments common sense experiments Science Education stupid laws The Guardian Submitted by Traci Purdum on Wed, 05/15/2013 - 15:25 Has a need to be politically correct at all times brought us to our knees in terms of innovation and exploration? Are we doing a disservice to students by stymieing their curiosity for fear of getting in trouble? Login or register to post comments Read more 3043 reads Permalink