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ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
Volume 17, 14 Issues, 2017
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Anti-Cancer Agents in Medicinal Chemistry
Formerly: Current Medicinal Chemistry - Anti-Cancer Agents
This journal supports open access
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Ranking and Category:
of 59 in Chemistry, Medicinal
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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne
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Editorial (Thematic Issue: Emerging Concepts and Therapeutics Strategies for the Treatment of Brain Tumors)
Anti-Cancer Agents in Medicinal Chemistry
): 1063-1064.
Jianliang Chen
Juan Sebastian Yakisich
Department of Clinical Neuroscience Karolinska University Hospital S-141 86, Stockholm, Sweden.
"There is no satisfactory treatment of glioblastoma multiforme of the brain" was the introductory sentence of an article published in 1967 by Jelsma & Bucy [1]. Unfortunately this poor prognosis has not changed during the last 45 years and this pessimistic statement remains largely valid. At that time the 5 years survival was less than 10%. A historical comparison of Kaplan-Meier survival plots made in 2000 by Dr. Eric Holland showed that about 90% of patients died within 5 years. Due to the poor prognosis of patients GBM has been called "the Terminator" [2]. Since its introduction in 2005, temozolomide (TMZ) has become the standard treatment despite the fact that the 5 years survival rate modestly increased around 20% [3]. As in 2010, TMZ in selected groups of patients had limited benefit [4]. Kast et al, pointed out that the 22 clinical trials reported in 2012 using drugs that showed promising potential in preclinical studies were found to minimally improve quality of life and overall survival when compared to the "Stupp protocol" [5]. In this hot topic issue we highlight few exciting areas that may provide useful ways to understand the complexity of glioma biology and its implication for the development of novel effective therapeutic strategies. Like in other cancers, the isolation of putative cancer stem cells (GSCs) in glioma cell lines and fresh specimens were received with great enthusiasm. The review by Alexandru et al "Selective Therapeutic Targeting of Malignant Glioma Stem Cells" [6] discusses the current therapeutic modalities for glioma treatment and highlights the potential underlying mechanism(s) for resistance to radiation and TMZ attributed to the presence of GSCs. Later on, the authors provide a list of potential targets that could be exploited to overcome the inherent resistance of GSCs. The list included microenvironemental factors (hypoxia), signaling pathways (Notch, Hedgehog – GLI, Epidermal growth factor receptor (EGFR), transforming growth factor beta (TGFβ), platelet derived growth factor receptor (PDGFR)), the c-Myc oncogene, the Bmi1 epigenetic silencer gene, overexpression of chemokine receptors, adhesion molecules, bone morphogenic protein (BMP), the stem cell marker CD133, miRNA and potential targets to overcome GSC immune surveillance escape. Some of these promising targets are further discussed in other articles in this hot topic issue. The article "Microenvironment and Brain Tumor Stem Cell Maintenance: Impact of the Niche" by Herold-Mende and Mock [7] gradually expands our understanding of the complexity of gliomas and provides additional therapeutic targets: the interactions with stromal cells, immune cells, their adjacent endothelial cells and the extracellular matrix. Immune targeting therapies are also likely to benefit from a better understanding of glioma biology related to cancer stemness. It was recently found that the cancer stem cell subtype classified as CD133+ CSCs (proneural-like CSCs) or CD133− CSCs (mesenchymal-like CSCs) may determine the response to immunotherapy and survival [8]. The original research article "Tapasin and human leukocyte class I dysregulation correlates with survival in glioblastoma multiforme" by Thuring et al, adds additional support correlating the dysregulation of tapasin and human leukocyte class I with survival of patients with GBM [9]. The influence of HLA-2 antigen presentation and tapasin is discussed in detail in the review by Darabi et al., "HLA-I antigen presentation and tapasin influence immune responses against malignant brain tumors – considerations for successful immunotherapy", that brings discussion on IFNγ therapy, cytostatics and irradiation [10]. Successful treatment of gliomas would likely require multimodality treatments and thus a better integrated knowledge of glioma biology is essential. The article "Translational gap in glioma research" by Ma et al. [11] raises awareness of the poor success on translating basic research into clinical trials. The potential of local delivery and nanodrugs-based therapies as way to increase the effectiveness of anticancer drugs and overcome the blood brain barriers is reviewed in the article "Overcoming the blood-brain barrier for chemotherapy: limitations, challenges and rising problems" by Wang et al. [12]. Due to the heterogeneity and complexity of glioma tumors prolonged treatment with high doses of anticancer agents will be necessary to cure cancer. Indeed few attempts has been done recently in this direction: i) a recent study showed that prolonged administration of adjuvant temozolomide improved the survival in adult patients with glioblastoma [13], ii) a two phase treatment using prolonged high exposure to anticancer drugs (e.g. alkylating agents or DNA replication inhibitors) followed by prolonged esposure to low concentration of salinomycin has been shown in vitro to prevent regrowth of glioma surviving cells [14, 15]. iii) a new proposal to increase overall survival and quality of life include adding already-marketed growth factor-inhibiting drugs to low dose continuous temozolomide [5]. Future improvements in drug delivery either by local or nanoparticles-based therapies in combination with prolonged treatments with less toxic drugs will be important to overcome the challenges due to tumor heterogeneity and the presence of the blood brain barrier. The potential tumorigenic properties of all glioma cancer cells likely due to their plasticity properties and its modulation by the microenvironment that allow interconversion between glioma stem cells and non-glioma stem cells [16-19] is a novel concept that is gradually being accepted as one of the major challenge to completely eradicate the tumor and prevent tumor relapse. The concept that to cure gliomas all cancer cells should be eliminated at once [16, 20] is now replacing the classical belief that cancer stem cells should be the main therapeutic target. For instance Schonberg et al. recently stated "To achieve a brain cancer cure, all tumor cells, particularly the brain cancer stem cells, must be eliminated" [21]. To be successful, other types of therapies not discussed in this hot topic issue but actively investigated (e.g. gene therapy, boron neutron capture therapy) should also take in consideration these novel concepts of glioma biology. At present nobody can predict which type of therapy will be the effective one and therefore any promising strategy is worth pursuing. However, as our knowledge of the complexity of gliomas increases it is likely that a multidisciplinary approach will be more advantageous over a single monotherapy modality. Novel multidisciplinary strategies need to be explored at earlier stages (during the preclinical development) and integrated during early clinical trials to avoid the translational gap of glioma research that if not corrected the prognosis of patients will remain as poor as it has been for the last five decades.
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16 To-Die-For Recipes with Cake Mix Free eCookbook
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"This recipe is perfect for my family. We love chicken/bacon/ranch combinations, and we love cole slaw. This will be a great meal served with fries. I think I'll make it over the weekend."
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text:
Instructors: Karen McCauley, Inga Thornell, Judith Holloway.
Optional for the Certificate. Required for the diploma
For many students, there is a large jump between knowing all the pieces and putting them together for a client. If you find synthesis a struggle, then this course is for you. Students will focus on finding basic themes, answers and interpretations using the natal chart to address client issues.
Primary Instructors: Karen McCauley and Inga Thornell. Guests have included Claudia Dikinis, Bob Glasscock and Donna Van Toen.
In this course, students will be introduced to considerations involved in astrological counseling, and to the process of working on relationship issues with clients, including finding relationships in the chart, organizing a session, methods of delivering content, ethical issues and referral strategies.
Instructors: Karen McCauley and Inga Thornell.
A good astrologer needs to know techniques, but they must also reflect upon their own world view, assumptions and other personal filters. In this course, students will be challenged to explore their own personal filters, attitudes and beliefs as they develop their chart interpretation skills. They will also actively consider and discuss potential client issues and ethical considerations. In addition, students get guidance in how to evaluate the strengths and weaknesses of different approaches to delineation by examining how multiple astrologers approach chart interpretation.
Instructors: Carol Tebbs and Jacqueline Menkes
This course moves the student beyond the basics of interpreting planets, signs, houses and aspects to where students can distinguish how these components are modified for each individual. Students are encouraged to critically consider the various techniques through a discussion of their strengths and weaknesses as well as any controversies surrounding them. Guided practice each week in "Live Chat" refines the process of spotting major life themes in the natal chart.


text: I am an Indian girl from Andhrapradesh. I am regularly getting dark spots on my face; creams are only a temporary solution, can you suggest a permanent one? These were caused by burns after laser hair removal. Had second treatment 15 days after first, but didn't tell the doctors I had applied bleach on my face.


text:
Buying a house is our goal but if we do so it probably won't be here. The
real estate market in NYC is absolutely ridiculous. A small one level one
bedroom cottage goes for 400K. Most homes here go for
700K or more. And the saddest part is that overdevelopment is rampant.. They
buy one house, tear it down and build 3 in it's place. Mike and I are
extremely blessed right now. We are able to make it in NYC on one salary, as
I have been unemployed since October. I was laid off along with 30 other
people. We are fortunate that we have a very nice place to live and can pay
our bills and put food on the table without worry. A lot of couples bringing
in two salaries in this area can't say that! My fiance is lucky to have a
very good and secure job and just got promoted! I am trying to find work but
it's difficult here, so I am trying to jumpstart my long neglected writing
career. Oh well, at least it gives me lots of time to garden! :-)
----- Original Message -----
From: "Bonnie & Bill Morgan" <firstname.lastname@example.com>
To: <email@example.com>
Sent: Friday, July 07, 2006 11:30 AM
Subject: RE: [CHAT] Goodbye Garden
> Well, the relationship matters much more than show, when it comes to
> married. I had a large wedding (for my day) and thoroughly enjoyed it,
> my DH hated the pomp. Mind you, I did most of my own "work" with mother
> taking care of the reception details. I made my own dress. Mother made
> bridesmaid's dresses and we took care of the decorations ourselves. We
> found bouquets for a song and made our own decorations and such. It was a
> lot of work. At that time, receptions weren't big sit-down meals and the
> bride and groom actually opened each gift and made a public
> of the gift. So our biggest expense was cake and ice cream for 300.
> You can have a nice wedding without breaking the bank if you have time to
> much of the work yourself. There are many books out there to help you,
> as well as some free advice and info on the web.
> What I enjoyed in having the "big" wedding was having people I had known
> whole life come to wish me well in my new life adventure. I got to see
> hug so many people and did my best to let them know that it mattered to me
> that they honored Bill and me with their presence. Daughter Tzeitel had
> her wedding in our yard. Talk about a small budget affair! Still the
> memories are good, the photos beautiful and they had money left for what
> they needed.
> Having said that, it is up to you and what you want, Sue. You could
> have a nice wedding and a down payment on a house if you keep costs in
> and don't go over what you have budgeted. You could even ask for cash to
> add to your down payment for a house as a wedding gift. Go for your
> Blessings,
> Bonnie (SW OH - zone 5)
> -----Original Message-----
> From: email@example.com [mailto:email@example.com] On
> Of firstname.lastname@example.com
> Sent: Friday, July 07, 2006 11:09 AM
> To: email@example.com
> Subject: Re: [CHAT] Goodbye Garden
> I am very intrigued that all you long-time married folks recommend eloping
> and not spending a pile of money on a wedding. A piece of land of your own
> certainly seems the better investment...'specially when it has space for a
> garden!
> I personally think that industry(wedding) is obscene but since I've been
> divorced for 30 years after being married 10 I didn't think my opinion
> have much credibility! Kathy
> ---------------------------------------------------------------------
> To sign-off this list, send email to firstname.lastname@example.com with the message
> text UNSUBSCRIBE GARDENCHAT
> ---------------------------------------------------------------------
> To sign-off this list, send email to firstname.lastname@example.com with the
> message text UNSUBSCRIBE GARDENCHAT
> --
> No virus found in this incoming message.
> Checked by AVG Free Edition.
> Version: 7.1.394 / Virus Database: 268.9.9/382 - Release Date: 7/4/2006
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE GARDENCHAT


text:
Need eBay and Amazon Sellers from all countries to sell new video game consoles, We pay you $50+ profits for every sale
This project received 10 bids from talented freelancers with an average bid price of $835 USD.Get free quotes for a project like this
Project Budget$750 - $1500 USD
Total Bids10
Project Description
We are suppliers of new video games consoles. We can supply new PSOne consoles, Playstation 1 fat consoles, PS2 slim consoles, Game Boy Advance SP consoles.
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About your profit %50:
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text:
Lawrance Database Designs
Specializing in developing customized database solutions with Filemaker Pro for education.
New Gradebook ver 4.0.1 for Filemaker Pro 14 and Filemaker Pro Go 14 for iPad.
This new product has implemented new features in version 14 that make it appeal to a broader range of educators such as popover buttons and panels that allow more information to be displayed on a smaller layout. In addition, SMTP email negates the need to use an external email client such as Microsoft Outlook etc.
Downloadable file and screen shots are available on the gradebook page.
Al Lawrance / Developer


text:
I think I'm too young to define myself as this or that, because I always find myself on a conflict between what I find to be right and my espontanious actions.
For now, I can say I love reading and writing. Thanks to my mom, who was always there motivating me to read more and more, books have been a huge part of my life since young age. They are my alternative universes, my way of running away.
Writing came along a lot later, when I was on 9th grade. I started looking for fanfiction and I felt the itch to write my own. This feeling made me start with, as I said, fanfiction, then I tried to write my stories with original characters. About two years ago, I decided to give poetry a shot. It is still not my best, but I enjoy what I write.
In the moment, I'm trying to improve my writing, as in vocabulary and sentence construction.


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Chilled Out,
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With soaring cliffs and majestic arches , McCloud Mountain is an awe-inspiring place to visit. It may be one of the South's best-kept secret.
* 1300 acres
* elevation of 2700 feet
* atop the Cumberland Mountains
* To the northeast of La Follette, TN
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* 25 minute drive from Norris Lake
Over fifty years ago, Jim McCloud purchased the tract of land that is now occupied by McCloud Mountain Resort. He began sightseeing tours of the mountain's many natural wonders and magnificent views. His dream of one day sharing the property has become the reality of Real Estate Developers Paul & Madeline Fields with the opening of a mountain top lodge, property sales, and what is easily one of the most unique restaurants that you will find anywhere.
Tennessee Vacation eGuide
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text:
A subspecialty certification by the Board of Internal Medicine. Hematologists treat diseases of the blood, spleen, and lymph glands such as anemia, clotting disorders, sickle cell disease, hemophilia, leukemia, and lymphoma. They perform special types of transfusions and biopsy the bone marrow for analysis.View More
1-5 of 5
600 Moye Blvd Ste 7S10
Greenville, NC 27834
401 N Main St
Kenansville, NC 28349
600 Moye Blvd Ste 3E127
Greenville, NC 27834
4420 Lake Boone Trl
Raleigh, NC 27607
1041 Noell Ln Ste 105
Rocky Mount, NC 27804


text:
More Videos...
2012 Mercedes-Benz CL63 AMG Start Up, Exhaust, and In Depth Tour
Hello and welcome to Saabkyle04! YouTube's largest collection of automotive variety! In today's video, we will take an up close and personal in depth look at the 2012 Mercedes CL63 AMG. German performance tuning and muscle at its finest. Opulent luxury and features, sleek seductive body styling, not to mention a new biturbo powerplant under the hood. Quite the head turner! During this presentation, we will take a 1st person look at what the vehicle is all about beginning with the start up, performance data, fuel economy, the occasional track data, and build quality. Also, I will teach you how to use most of the interior and exterior features in a detailed fashion, that before, you could only get from going to a dealership yourself! Throughout the video, I will highlight key styling and unique differences about the vehicle, any available options, and of course it would not be an enthusiast car video without the good ole engine portion with rev and Exhaust note with interior and exterior perspectives. A thorough tour/review of this car designed to give others a greater overall appreciation of the vehicle. FOR MORE INFORMATION ABOUT THE CHANNEL SEE BELOW: In this channel you will find in depth reviews/tour of automobiles from all over the world, presented in a more detailed fashion than ever before. Basically, this gives the viewer the chance to view the most detailed 1st person look you can get without going to an actual dealer yourself! Every video is consistent in the way I present so viewers know what to expect in my presentations. I treat every vehicle with the same respect whether a 1960 Chevrolet Impala SS or the 2012 Lamborghini Aventador. I film all types of vehicles from past, present, and future while broadening the knowledge of the automotive enthusiast. You will see everything from vintage, brand new, exotic, mainstream, old, etc. I am very proud of this channel and have built it up from amateur videos years ago to what you see today. I wanted to share my love for the automotive world with the rest of the world. Be sure to explore the massive video variety, have fun and enjoy The Driver's Seat of YouTube! FIND ME ON THE OFFICIAL SAABKYLE04 FACEBOOK PAGE FOR CONTINUOUS UPDATES ON WHAT'S TO COME AND INTERACTING WITH OTHER FANS! http://www.facebook.com/pages/saabkyle04/315743567772
Mercedes CL 65 AMG Start-Up and Acceleration Hard Sound
Mercedes Benz CL 65 AMG - 330km/h - 660PS - CL65AMG
Hier ein kleines Video vom CL65 AMG. Das Auto wurde von der Firma VÄTH getuned.
Aston Martin DB9 vs Mercedes-Benz CL65 AMG! - Head 2 Head Episode 26
German engineering meets British charm as Jonny Lieberman pits the 2013 Mercedes-Benz CL65 AMG against the 2013 Aston Martin DB9 on this episode of Head 2 Head, While both brands are synonymous with luxury, underneath their hoods lies some seriously massive hand built V-12 engines. Dynamic testing & mountain roads await as we find out which is the better super coupe for the modestly wealthy. Head 2 Head appears every other Wednesday on the new Motor Trend channel. http://www.youtube.com/motortrend Subscribe now to make sure you're in on all the action! http://www.youtube.com/subscription_c... Facebook - http://facebook.com/motortrendmag Twitter - http://twitter.com/motortrend Google+ - https://plus.google.com/1018679678590... Website - http://www.motortrend.com


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Lot 48: Panama 1980 Gold 100 Balboa (.2361 oz AW). Gem Br. Proof
Mitchell Auctions #10 Rare Coins, Currency, and Medals Auction
by Mitchell Auctions
29 October 2016
Garden City, NY, USALive Auction
Looking for the realised and estimated price?
Description: Panama 1980 Gold 100 Balboa (.2361 oz AW). Gem Br. Proof and housed in its original Franklin Mint holder of issue. The reverse depicts a stylized condor. One of 2411 such proofs struck. Est. $310.
Browse more items


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Lot 164: Ray Bellisario (b.1936) - Brigitte Bardot, 1968
Fine Photographs
by Dreweatts & Bloomsbury
October 20, 2016
London, United KingdomLive Auction
Ray Bellisario (1936-) Please Register/Login to access your Invaluable Alerts
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Description: Gelatin silver print, printed later, signed and editioned 1/25 in pencil with gallery's stamp verso, 35.5 x 24.1cm (14 x 9 1/2in)
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This proposal requests continued support for the Medical Scientist Training Program (MSTP) at Vanderbilt University. The primary goal of the Vanderbilt MSTP is to identify, mentor, and foster the careers of future leaders in academic medicine who are dedicated to improving human health through research. The program is based on rigorous training in clinical medicine and scientific inquiry. Successful completion of the MSTP leads to both M.D. and Ph.D. degrees. Core elements of the program developed specifically for dual-degree students include a literature-based seminar series, clinical preceptorship program, data club, leadership workshop, career development workshop, physician-scientist speaker series, and an annual retreat. Formal instruction in responsible conduct of research is provided throughout the curriculum. An innovative advising college program offers opportunities for student advising by faculty members and senior trainees. The MSTP supports students enrolled at both Vanderbilt University and Meharry Medical College. Seventy-four percent of our graduates with established careers hold academic or private-sector research positions, including two deans and 20 full professors. More recent graduates still in training have been placed in superb residencies and fellowships. The 84 current trainees come from 59 colleges and universities distributed across North America. The nationwide applicant pool results from concerted recruiting efforts, including those focused on the recruitment of students from groups underrepresented in medicine. In the current year, 275 applications have been received, from which 12 students will be selected to enter the incoming class. The proposed goal is to increase the size of the program to a steady state of 96 students over the next five years. The educational environment for physician-scientists at Vanderbilt University is outstanding. Extramural research funding has increased from $256 million to $389 million since 2003. Building on established strengths in cancer biology, cell biology, clinical pharmacology, diabetes, signal transduction, toxicology, and vaccine science, new areas of research emphasis include biomedical informatics, chemical and physical biology, genetics, imaging sciences, neurosciences, and structural biology. The proposal requests an increase in funded positions to 32 (29 for Vanderbilt;3 for Meharry) during the five-year project period. Ongoing support for the Vanderbilt MSTP is based on the strength of the applicant pool, enhanced opportunities for physician-scientist training, and an institutional commitment to the education of leaders in biomedical research. The Vanderbilt Medical Scientist Training Program supports the training of physician-scientists who seek to improve human health through basic, translational, or clinical research. The broad public health significance of this program will be realized through the academic and scholarly accomplishments of the trainees, with connections to both the direct treatment of patients in the clinical setting and the discovery of basic disease mechanisms and new therapeutic agents.
|Lai, Caroline M; Boehme, Karl W; Pruijssers, Andrea J et al. (2015) Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J Infect Dis 211:383-93
|Parang, Bobak; Rosenblatt, Daniel; Williams, Amanda D et al. (2015) The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J 29:786-95
|Aboud, Asad A; Tidball, Andrew M; Kumar, Kevin K et al. (2015) PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Neurobiol Dis 73:204-12
|Umunakwe, Obi C; Seegmiller, Adam C (2014) Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase. J Lipid Res 55:1489-1497
|Talati, Pratik; Rane, Swati; Kose, Samet et al. (2014) Increased hippocampal CA1 cerebral blood volume in schizophrenia. Neuroimage Clin 5:359-64
|Hohman, Timothy J; Koran, Mary Ellen I; Thornton-Wells, Tricia A et al. (2014) Genetic modification of the relationship between phosphorylated tau and neurodegeneration. Alzheimers Dement 10:637-645.e1
|Reddy, India A; Stanwood, Gregg D; Galli, Aurelio (2014) Moving beyond energy homeostasis: new roles for glucagon-like peptide-1 in food and drug reward. Neurochem Int 73:49-55
|Freeman, Megan Culler; Graham, Rachel L; Lu, Xiaotao et al. (2014) Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. J Virol 88:5319-27
|Metcalf, Jason A; Funkhouser-Jones, Lisa J; Brileya, Kristen et al. (2014) Antibacterial gene transfer across the tree of life. Elife 3:
|Markham, Nicholas O; Doll, Caleb A; Dohn, Michael R et al. (2014) DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia. Mol Biol Cell 25:2592-603
Showing the most recent 10 out of 237 publications


text:
Here's a helpful article:
Basically, you're probably fine for most stuff, but don't do it for stuff that's really stained, really matters to you, is made of leather, or is highly constructed (like a suit coat). They point out you should use cold water, a hand-wash cycle and a gentle cleaner.
Personally, I don't have much that is dry clean only. So fortunately I don't run into the issue much.
maven3 (rep: 5.2k) posted Apr 26, 2012
Thanks, maven3! I wear suiting ensembles for work and thankfully they've been okay. I think I will switch to the hand wash cycle, I don't want to press my luck (they are The Limited and Body by Victoria brands so not the most high-end but pretty high-end to me, lol).
I also just read that Woolite is pretty gentle on clothes, but as it is more pricey I'll wait for a sale + coupon :)
dealwagger (rep: 10.3k) posted Apr 26, 2012
For the Victoria Secret stuff, just put it in the wash like you regularly do but take it out and lay it out to dry instead of using the dryer. The dryer eats up the bras and spits out these deformed...things. Haha
arsiel (rep: 13.1k) posted Apr 27, 2012
@arsiel Does it ever! That's what I do, air dry, otherwise nice bras and garters and those lacy thongs that should last forever are ruined in one or two washes. When I have time, I hand wash. I hate those deformed things! It makes me shudder to see that LOL
dealwagger (rep: 10.3k) posted Apr 27, 2012
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Student Financial Aid
The mission of the Office of Student Financial Aid (SFA) is to provide financial aid to students who would be unable to attend the University without such assistance. Additionally, our mission is to also support the success of colleges and students in their commitment to academic excellence through outstanding service. We strive to provide a student-oriented approach in the administration of financial aid programs by being responsive to the needs of students, their families, and other constituents. These pages are dedicated to helping prospective and currently enrolled University of Kentucky students apply for and secure financial assistance to help meet the cost of attending UK.
Summer Outreach Dates
The Financial Aid office was out at different locations through the summer to get your questions answered about financial aid. For more information visit here.
Financial Aid Help Desk will be held the following dates:
- Tuesday, September 6, from 11 a.m. until 1 p.m. at Starbucks, W.T. Young Library
- Tuesday, October 4, from 11 a.m. until 1 p.m. at The 90
Freshmen beginning fall 2016-17
- 2016-17 financial aid award notifications will be mailed and will also be available on the myUK web portal in mid March.
Returning and Transfer students for 2016-17
- 2016-17 financial aid award notifications will be available on the myUK web portal in mid June.
The University of Kentucky's Title IV code is 001989
IMPORTANT ANNOUNCEMENT for 2017-2018
-The 2017 – 2018 FAFSA application will be available beginning October 1st, 2016 at www.fafsa.gov
-Applicants will use prior-prior year tax information (ex. 2015 tax information for 17/18 FAFSA)
-New FAFSA applicants should apply for their FSA ID in advance at: fsaid.ed.gov
It is important that applicants apply for the FAFSA as soon as it becomes available in October. Some financial aid is awarded based on the initial FAFSA filing date. Using prior-prior year tax information will make the FAFSA process easier for families and students. To make the FAFSA even easier, use the IRS Data Retrieval Tool (DRT) that is available through the online FAFSA.
The chart below shows how the FAFSA filing date is changing:
Watch the video below for more information of the new FAFSA filing date and prior-prior year information: https://www.nasfaa.org/ppystudents


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This review is from: XION XON-1000P14F High Performance 1000W Power Supply, compatible with Intel Sandybridge Core i3/i5 /i7 and AMD Phenom ,SLI/Cross Fire Ready, ATX 12V, EPS 12V v2.91 and SSI v2.91, Six 12V Rails & 8 x SATA
Pros: here is the reason i bought this power supply
there are alot of options for this psu.
alot of power connections. you can have up 2 7 hard drives
psu 1 for blu-ray drive or dvd-rom
you get a option to upgrade to higher cards. such as nvidia 600 GTX series or the new AMD radeon HD 7000 series.
this psu give perfect idea for the AMD FX cpu or intel 3rd gen cpus.
it can power alot of fans! and does not give out.
a must have for those who are building or want to build a Home theater PC. so you can raid 4 or more drives. they now make 3tb drives for 16tb thats a dream for a home theater user who wants the space for the hauppauge colossus card. because the file size for that card is blu-ray size.
Cons: i dont have any cons to give.
Other Thoughts: here is my contruction build plans for a HTPC.
1 Gigabyte GA-990fxa-UD3 features (DOLBY HOME THEATER v4 required for external receiver)
2 of the ASUS AMD RADEON HD 7770 2gddr5 in crossfire X
4X8 32gb of 1866mhz which i own.
4 3tb of seagate 7200 rpm 6gb/s burricuda drives.
1 blu-ray writer/player (which i own)
1 hauppauge HD colossus card.
1 AMD FX 8 core 8150 (which i own)
1 nvmedia 6000b HTPC black case
and windows 8 pro 64-bit (coming soon)
This review is from: ASUS Radeon HD 7770 DirectX 11 HD7770-2GD5 2GB 128-Bit GDDR5 PCI Express 3.0 x16 HDCP Ready CrossFireX Support Video Card
Pros: this card is perfect i am enjoying it. stable frame rates. no bottlenecks after installing 1000w psu. runs like a dream with the AMD FX 8 Core 8150 cpu. with 32gb of 1866mhz of ram. and i am still on windows vista 64-bit ulimate.
here are the frame rates for the games i have. vsync on
battlefield 3 (on auto mode 60 frames @high with medium)
alice madness returns (60 frames @ultra with physx to low)
blades of time (60 to 80 frames @ ultra)
mass effect 3 (60 frames lock down @ ultra)
ghostbusters the video game (60 frames @ultra)
street fighter X tekken (60 frames @ ultra)
medal of honor reboot (60 frames @ ultra)
rage has a problem due to programing (30-50 @ ultra)
star wars the force unleshed 1 and 2 (60 frames @ max)
sanctum (60 frames @ ultra)
i know there are more games i own on PC. i have over 1000 games. and still collecting. so its good to go back and see how fast these older games run. this card also loves OPEN GL games. the opengl games run from 15
Cons: this is not a con. there was a problem with my drivers after installing. i found out my diamond card was faulty. so it does not work. i sent the card back to diamond they replaced it already. but the ASUS card did not have a problem with drivers.
Other Thoughts: i cant wait to get one more of these cards next month! thank you newegg for restocking them. i am building a HTPC ATX with crossfire X. and no i am not sending this card back.READ FULL REVIEW
This review is from: ASUS Radeon HD 7770 DirectX 11 HD7770-2GD5 2GB 128-Bit GDDR5 PCI Express 3.0 x16 HDCP Ready CrossFireX Support Video Card
Pros: heres what i like about this card.
the duel fans keep the computer quite! and i do mean quite. games run perfect at auto settings. most of the new games default at HIGH mode (max) or ultra high mode (battlefield 3 will default to high mode with some medium settings)
you got to love the 2gddr5 on this card. it works on alot of games that need that extra ram. this is my second overlocked default card. i am happy with not having to miss with the overclock settings on this card. just pop it in and play. no need to worry.
Cons: heres what i did not get and it was a con. but its nothing to worry about due to me not knowing what i needed first.
while there is a problem with crossfireX with other cards. this card has killed my diamonD AMD radeon HD 7770 1gb gddr5 card. which i bought like 3 months ago. it needs a real 450W power supply. which i did not go read at ASUS main web page. so for crossfire X i need a 1000w for this to work.
it eats alot of energy. lucky i am going to fixed this i just ordered a XION 1000w high proformance non energy saving PSU from NewEGG.
Other Thoughts: i really love this card. but i am just sad that Newegg has not restocked this card yet. its a must for the gamer that wants to get there dream build to 4GB gddr5 cards in 2 way crossfirex. hopefully by september newEGG gets more.READ FULL REVIEW


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It is quite understandable that there are some unwritten rules for pictures sizes in digital photo portfolios. However, there are many photographers with numerous large and beautiful photos. So MotoCMS decided to present you this Flash photo gallery for the best displaying of widescreen photos. From now on you can upload images of different resolutions and view them in details with the special zoom tool. A small zoom window is located on the lower right corner of the template and can be easily minimized.
There are also increase and decrease buttons which will help you to take a good look at every picture. It is also possible to print and download images from the gallery. And what is more interesting you can supplement every picture with a description which can be as long or short as you need. Every image description is opened in a separate popup, so you can arrange it at your will.
The template also includes original Background slot which enables you to change background colors manually.


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Certified Organic Cardamom Whole Green - Indiaprice: contact company for price
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Published date: September 7, 2012 -
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By looking at the overwhelming response from the market the management decided to establish a new venture in the field of plastic production and continues to grow even today to fulfill the needs of market.
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50% recycled cotton / 50% recycled plastic water bottles
Regular fit
Made in U.S.A.
|Free Shipping
Figured I try this thing out and it is awesome. I got a navy one and it looks awesome and is more comfortable and durable than a light weight sweater


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how to winterize gardens download t7j6 free file
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*Supported OS: All
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02/23/2015 03:03:58
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By Kaylen Auer
PBN Web Editor
Since MakerBot Industries began selling its first kits in 2009, the commercialization of 3-D printing has been gaining steam, both within the maker movement and in the mainstream media, as an idea with the potential to revolutionize manufacturing.
How and when that revolution will take place, and whether 3-D printers will remain an industrial technology or become household appliances, is the subject of ongoing debate among enthusiasts – a schism personified by two startups in Betaspring's latest accelerator cohort introduced on April 24.
"The Web is going through an evolution from 2-D to 3-D environments, and we're seeing this move from bits to atoms, from digital to physical, that's best embodied by 3-D printing," said Allan Tear, co-founder and managing partner of Betaspring. "In some ways, it's consistent with our core philosophy of what Providence is uniquely good at, which is the intersection between design and physical technology."
The two companies – 3DaGoGo and Mebotics – are the first to attend Betaspring's program that are developing tools directly related to 3-D printing technology, rather than simply using 3-D printing as a means to develop a product or prototype. Aside from that distinction, however, they have almost nothing in common: while 3DaGoGo, founded in San Diego, is developing software geared toward 3-D printing novices, Somerville, Mass.-based Mebotics works in hardware designed for small businesses and manufacturers.
3DaGoGo and Mebotics are part of a spring 2014 class that includes five other startups and two "Betaspring Fellows." The cohort was selected from a pool of roughly 300 applications, according to the accelerator. During the first half of the 12-week program, the teams have worked with Betaspring mentors and experts.
Mebotics co-founder and CEO Jeremy Fryer-Biggs came into the 3-D printing space from a background in product development and became interested in the technology because of its applications for making unique, one-off parts that can be used to build almost anything.
"Physical products govern everything that we do in life," said Fryer-Biggs during his pitch to a crowd of 300 at the accelerator's spring open house last month. "Products account for $2 trillion in the U.S. economy, but only 7 percent of startups make things because traditionally it's very expensive."
To tackle that problem, he and three friends designed the Microfactory, a hybrid 3-D printer and CNC milling machine that combines both additive and subtractive prototyping in one "desktop machine shop" that can shape wood, plastic or aluminum.
According to Fryer-Biggs, it's the first machine of its kind at a price point affordable for small businesses (the base machine costs $3,195), and it can print in up to four colors or two different materials at once for fast, custom prototyping.
What the Microfactory is not, however, is a tool designed for mainstream consumers. That's where 3DaGoGo comes in. The cloud-based software they're developing would walk first-time printers through the process of uploading a file for print and analyze the file for potential problems such as holes in the design that could cause the print to fail.
"We want to facilitate the move from hobbyists to early adopters," said Drew Taylor, "moving from techie individuals to people who don't want to tinker for an hour to print something." Taylor founded 3DaGoGo with Daniel Arroyo and Joshua White.
Currently, Taylor said, someone who designs a 3-D print file from scratch or downloads one from a community website like Thingiverse (or 3DaGoGo's own online marketplace) uses one of three main programs to prepare a 3-D file for print: NetFabb, Slic3r or RepetierHost.
However, these programs come loaded with more than 100 settings to be tweaked and tuned. 3DaGoGo aims to bring that number down to three settings and move toward a "one-click print" model for 3-D printing.
Using 3DaGoGo still requires a certain degree of technical know-how, Taylor said, and it is geared toward people who are new to 3-D printing but are generally accustomed to experimenting with new technology.
To make the jump to the mainstream consumer, 3-D printing hardware and software will need to become more intuitive, Arroyo added, but by helping to make 3-D printing more accessible to first-time users, 3DaGoGo hopes to fuel what they see as the future of the 3-D printing movement – a microwave-like device accessible to the mainstream consumer and operable at the push of a button.
"It literally will mean a 3-D printer in every home," said Arroyo. "It will be a $200 machine that you buy at Staples or Walmart that your kids ask you to buy."
Fryer-Biggs envisions a different future for the technology. Current 3-D printer models are too expensive and too complicated to use, he said, and to take full advantage of the technology requires the ability to design or modify 3-D print files using CAD software. In addition, the products 3-D printers can make and the materials they are made out of (typically plastic) are not of a quality that mainstream consumers will appreciate.
Instead of 3-D printers finding their way into consumers' homes, Fryer-Biggs said, they are more likely to become widely available through stores and shared community printing spaces, like FedEx or a 3-D printing café.
3-D printing also has commercial applications. For example, Fryer-Biggs said, in the future a retailer like AutoZone could 3-D-print parts for older or less-common automobiles, meeting those customers' needs without the expense of keeping those parts in stock for the small percentage of customers who need them.
"I actually think that those two viewpoints are where the whole 3-D printing industry is sort of duking it out right now," said Wayne Losey, creative director at Providence-based Dynamo Development Labs and a Betaspring mentor. "The media has really latched onto the idea of you owning your own capability and making your own product, and the sort of status quo in 3-D printing up to this point has been, 'This is not for everyone; this is for high-end designers; these are not toys.'"
The companies that ultimately decide the direction of 3-D printing may be startups like 3DaGoGo and Mebotics, Losey said, but Mebotics especially will have to overcome the challenge of attracting enough funding to finance its Microfactories.
After launching an unsuccessful Kickstarter campaign last year to raise $1 million for production costs, Fryer-Biggs said he gained a better appreciation for the challenge of raising capital and is currently exploring partnerships with two large-scale manufacturers to build the Microfactory on their production lines.
In the meantime, MAKE Magazine last November named the Microfactory among the top 3-D technologies to watch in 2014, and although it is not currently on sale to the general public, Mebotics has sold a number of beta units to select local companies who have offered feedback on the machine's functionality. He hopes his stay at Betaspring, under the tutelage of experts and mentors such as Losey, will provide the momentum needed to take the Microfactory to the next level.
"3-D printing is not only fashionable but it's captured people's imaginations," said Losey. "I think that we're still in an early spot, still in the pirate days of 3-D printing. … The big winners will be people facilitating use to novice users and people that are helping to advance the science, materials, print technologies and visualization and design." •
Monday, February 20
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DAVID HASSELHOFF - Knight Rider interview, and KITT!!
Check out our long feature on KITT, the Hoff and the ultimate fan: https://www.youtube.com/watch?v=XfxPWkQIOk8 KITT returns to the desert along with Michael Knight himself. DAVID HASSELHOFF sits with Christopher Rutkowski and goes for a drive in KITT. El Mirage lake bed is the original shooting location for the 19080's TV series KNIGHT RIDER. We bring both TV stars back home to tell us all about KITT, cars and what working on the show was like. We also recreate one of the most iconic shots of Michael Knight in the driver's seat. This is the first time this has been seen in 30 years! As always enjoy, share and SUBSCRIBE! clicking LIKE helps as well ;) keep an eye on exciting stuff that's coming up, Like us on FACEBOOK: https://www.facebook.com/theAFICIONAUTO instruct me on how to use twitter by following our TWITTER: https://twitter.com/theAFICIONAUTO I love instagram, and if you do too then follow our INSTAGRAM: http://instagram.com/theAFICIONAUTO
Original KITT car from Knight Rider
This is 1 of 3 original KITT cars they used for Knight Rider. The thing is SWEET! Super shiny, glare all over. All the interior buttons and electronics are lit up and look absolutely amazing. It's currently for sale at Kasabian Motors for $150k..
kitt building
Construction et réalisation de mon KITT


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Season 2 of the Overtime podcast is here! Listen to the first episode with Meg Robichaud now.
I suck at camshots*. Forgive me. I repent. Okay, here lies a login form. I made it last night. It's a project I'm working on in my bits o spare time with @mediahack. He is my friend.
*Deleted the stupid camshot. Put this shot up.
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This is the fifth in a multi-part series, The Year in Television 2011.
Tastes in television can of course be very subjective. One show may be your cup of tea, but not for the person sitting next to you. For instance, I love Louie, but my husband can't stand it. I thought Torchwood: Miracle Day was a yawner, and yet the show seemed to have its vocal fans right here on AfterElton.
But where reasonable people can differ on any number of shows, the list below we can probably ALL agree on. These are the true TV stinkers of 2011. Now there probably were worse shows in 2011 than what appears on this list (H8R for instance), but all the projects appearing below added insult to injury: they might actually have been good. Our list includes the new shows that totally botched a decent concept… or squandered a good cast. And it includes mature series that suddenly hit the creative skids.
In short, these were all programs that seemed encouraging, but ended up encouraging us to quickly change the channel.
Charlie's Angels
Goodbye Angels!
What went wrong? The very well-known name brand had a lot going for it, including Drew Barrymore as an executive producer, but the cracks were showing even before the premiere when a preview of the reboot at Comic Con was widely panned.
Problem number one was the casting. We loved Minka Kelly as a Texas cheerleader in Friday Night Lights, but she wasn't up to the task of anchoring a series of her own. And other than the delectable Ramon Rodriguez as Bosley she got little help from her castmates.
Where was the modern day Farrah Fawcett. Or even Cheryl Ladd? The stiff-as-a-board performances from these latter day angels couldn't even live up to the work of a Tanya Roberts or a Shelley Hack.
But the bigger problem may have been audience expectations. The original series created "jiggle" TV, and sent pretty girls running and jumping through a typical backlot detective landscape. The Barrymore movie remake turned the Angels into something goofier, almost campy. The new TV series might have gone either of those routes, but instead seemed to take itself very seriously, and the show suffered for that.
By turning itself into typical crime procedural, Charlie's Angels seemed like another episode of Law & Order… with three dull Mariska Hargitays instead of one.
Desperate Housewives
Oh, how the mighty have fallen from their towering Louboutins.
At one time, Desperate Housewives was one of the sharpest, wittiest shows on TV, filled with delightful characters and twisty stories that people could relate to. It looks like this series has simply run out of ideas and stayed on the air at least one season too long.
This eighth and final season began with the Wisteria Lane housewives secretively burying a murder victim. It devolved quickly into more familiar territory: alcoholism, adultery, impotence, divorce, suicide, and the PTA. The stories were all familiar, and viewers began to wonder about the value of it all. As they wondered, they wandered off.
An unforgivable sin of the final few seasons has to be the way gay characters were introduced and shifted to the sidelines. The show initially invested in Bree's gay son Andrew, and even introduced his porn star fiancé. New gay neighbors Bob and Lee dropped in from time to time to add some sass and complications, but they too seemed to drop off the block.
It's a familiar story: top-rated series stays on the air a couple of seasons too long, and limps off the air. This may be the saddest, most underwhelming end to a series in memory.
Some say Dexter is spent, that this show reached such dizzying heights in the John Lithgow/Trinity fourth season that it can never recover. While I hope there may be some hot blood still pumping in Dex, I'm afraid they may be right.
This isn't the fault of series star Michael C. Hall who still turns in an exciting, absorbing performance episode after episode. But after six seasons his "dark passenger" has become predictable and repetitive. Sure, major characters die, Dexter finds more visual ways to kill, and he puts himself in ever greater danger. But somehow, we're beginning to realize that it all may not add up to very much.
Admittedly, there was probably nowhere to go but down for this series. After the Trinity story arc, when Dexter returned home to find his wife dead and his baby in a pool of her blood – how can you top that?
How to Be a Gentleman
This show was so bad it was rumored to have been cancelled by CBS while the premiere episode was actually running.
Handsome Texan David Hornsby left It's Always Sunny in Philadelphia to write, produce and star in Gentlemen with Kevin Dillon (the man responsible for Drama, the mostly unlikable character from the usually enjoyable Entourage).
An updated and unfortunately less funny Odd Couple, the series chronicled former high school classmates as they attempted to renew a friendship that may never actually have existed before. Hornsby played an uptight columnist (is there any other kind on TV?) and Dillon was an Iraq War veteran and personal trainer.
The jokes were lame and sparse, the sexual situations were gross, and there was some farting. It was like an episode of Whitney, but with guys in charge.
Pan Am
Try as it might, this flightless bird couldn't get off the ground.
Millions were spent on extravagant sets, designers were hired to fashion retro "stewardess" uniforms, dour indie-Queen Christina Ricci was hired to give the period piece quality acting sheen, all to no avail.
Influenced by the critical success of the superior macho-retro Mad Men, producers spent $10 million on the pilot. Scripts were written to promote stories featuring the women in the cast. Initial critical reviews were largely positive, most expressing the theme that the show would develop and grow and "find its legs."
Unfortunately, that's proven not to be the case. Audiences haven't exactly flocked to Pan Am, and the show has reportedly been cancelled. The show grew to be vanilla and blah instead of thrilling. It was like an airline meal. The box looked nice, the contents? A little dry.
Pan Am turned out to be another nighttime soap. It had the angry mistress, the jealous sister, the mean-as-nails professional. We've seen this before. Sure, Pan Am shows the double standards women faced fifty years ago. But, oops, the women seem to accept them, even as they are being presented as strong women. The show can't help but seem bland as the "coffee, tea or milk" they served their passengers.
The Playboy Club
Here was a show your grandpa could watch. If your grandpa was Hugh Hefner.
Playboy the magazine is so old and out of touch, there's no way it would interest the core demographic that TV lusts for: age 18-39, mostly women. It seems to me that the market for The Playboy Club was my dad's generation, not a highly prized demo, by the way.
So they licensed the Playboy name and logo, built some sets, refashioned the bunny outfits, hired some decidedly gorgeous actors, including the ever-attractive Eddie Cibrian, and the gorgeous, out actress Amber Heard. Unfortunately, Cibrian was given little to do other than strut around the club attempting a John Hamm impression, and Heard was little more than eye candy.
The freshest storyline was gay and, from my perspective, was given short shrift. Alice, a lesbian bunny played by Leah Renee Cudmore, married her gay husband (Sean Maher) so they could hide their true identities … while raising money to found the early gay rights group, the Mattachine Society.
Instead, The Playboy Club turned out to be another soap without foaming action. Having the ubiquitous Parents Television Council hound the show didn't help, either. Instead of licensing the Playboy name and logo, producers should have looked at other magazines that would have offered viable dramatic story arcs to entice an audience: how about Men's Health or Highlights?
Prime Suspect
"Re-imagined" from a highly-regarded British series of the same name, the American version made nearly all the mistakes of past failed TV transplants:
They replaced sleek London with gritty New York, gentle Bobbies with grimy street cops, sadistic, refined, upper-crust serial killers with sadistic, refined Wall Street types. Oh, and they made the lead character about 20 years younger.
A little disclosure, I love Helen Mirren and the original Prime Suspect. She played an aging Inspector, scraping and scrambling against all manner of superior males to carve out a career in the police force. When she finally gets her chance, she mostly succeeds.
The American series, however, did not have the same importance as the import. A version of Mirren's terribly flawed character with all her demons and addictions might have worked on cable, but it never would have been allowed on NBC. Still, Maria Bello, a fine actress from Coyote Ugly and A History of Violence, gave it a shot. She fashioned an authentic winter wardrobe, including a hat that evoked Telly Savalas' Kojak, and she developed a confident strut that made her both the smallest, and the most important person in the room.
But the same can be said for a dozen other police procedurals on TV. Prime Suspect had a great lineage, and could have been a contender. The only great thing about this adaptation though, was the hat. The hat was genius.
Star of a beloved series waits for years to return to TV, chooses a prestige project, assembles a superb supporting cast, and launches … on the CW?
Buffy's return to series TV was ranked by most critics as the #1 must-see event of the season, and why not! Ringer promised viewers a great TV actress taking on a dual role, like Elizabeth Montgomery playing both Samantha and Serena on Bewitched. But without the laugh track.
Turns out the show probably could have used a little levity, anything to break out of the pack. It also could have used the prestige of a bigger network, a little viewing power to get it – and keep it – going. Instead, after a fairly encouraging debut, it faded away.
Sarah Michelle Gellar has brought verve to TV before, but there just wasn't much she could do with what turned out to be a glossy, convoluted version of a daytime soap plot. Playing twins has been done to death on daytime. Applying an impenetrable storyline didn't help viewers who attempted to join the show late. Giving Gellar's character(s) dour, haunted lines removed her best opportunities to be entertaining.
Kudos for luring the gorgeous Welsh actor Ioan Gruffudd to series TV, but The Ringer sounded hollow and just wasn't the right vehicle for SMG. Better luck next time Sarah Michelle. And if it has to be twins, consider the Samantha/Serena combo. You'd look great in a black wig.
Terra Nova
You'd think that for all the money FOX reportedly poured into this production at least the CGI dinosaurs would look real. They didn't. But then again, we thought the human cast was equally two dimensional. And the scripts – they could easily have been taken from the Land of the Lost reject pile. I kept expecting Chaka and the slestaks to wander through the set.
This was supposed to be a family-friendly show, and that might have been Terra Nova's biggest misstep. In trying to please both kiddies and adults it wound up pleasing no one.
X Factor
Even though it has been renewed for a second season, X Factor may ultimately be the most disappointing show of the year. The finale this Thursday night crowns a winner, but will many viewers care?
Bedeviled by the year's time it took to launch the show in America, TV's music competition landscape simply shifted between Simon Cowell's departure from American Idol and X Factor's premiere.
Idol was rejiggered to higher ratings glory with the addition of two aging superstar judges, and the gimmicky, highly accessible The Voice crowned a popular winner to ratings success. Meanwhile, Simon pressed forward with his British transplant and predicted out of this world viewership. He hired and fired judges. He returned Paula Abdul to his side. He hopped on and off a series of private aircraft. One thing he got right: importing Steve Jones to a grateful, slobbering America.
But when the bloated thing finally premiered, ratings didn't exactly raise the roof. And I don't see any way they could get better, with forgettable contestants performing mostly older songs by vintage acts like Hall & Oates, Madonna, Culture Club and the Supremes. This isn't exactly cutting edge stuff.
So that's it for our list of the year's biggest TV stinkers. Agree? Disagree? What would be on your list?