text:
Are you looking for Bakery Boxes? Hotfrog showcases more than 50 popular businesses related to Bakery Boxes! To find more business related to Bakery Boxes, use the left navigation menu.
Conover, NC
Bakeabox bakes up a great selection of stock cake, pie and pastry boxes and sells them at great prices. We are the manufacturer and because we elimi…
More info
Lakeland, FL
y,newspapers,printed materials,foam,meat,fabrics,bakery boxes, corrugated boxes,takeout food boxes,pvc piping,textile goods and the list keeps going.…
- 06/10/2011
- 12/14/2010
- 09/19/2010
- 09/02/2010
- 08/11/2010
Leading Manufacturer and Distributor of Pizza and Bakery Boxes
Simon Box Manufacturing and Printing www.simonboxco.com Cake boxes, drums, boards, bakery boxes and bags lockport Illinois
Cake BoxesCake Boards
We describe ourselves as a specialty baked goods company, a "boutique" bakery, with a classic feeling and beautifully presented items Very proud of what we had both accomplished we loaded the bakery boxes into t…
Fairmount, OH
Paper Products Company of CIncinnati supplies a full line of bakery boxes and stock and custom paperboard packaging for food packaging, paczki, medical, and industrial uses
Stock Cartons
Youngsville, NC
EastCoast Packaging Corp. is a leading manufacturer of plain rigid set-up boxes, plain and printed folding cartons, and insert/outsert trays for the pharmaceutical, food, apparel, printing and other industries. EastCoas…
Bolingbrook, IL
The Custom boxes are one of the best online packaging and printing company in the USA. We have a large variety of unique and creative boxes custom design and templates. Our boxes are available in every shape, size, and s…
Candy Boxescosmetic boxesPIZZA BOXES
Anaheim, CA
We are local bakry which always provide fresh and tasty cakes! If you want to surprise your guests and friend on your wedding or birthday party - just call us! We also provide delivery! Reach us at (714) 883-0341!
Missouri City, TX
TheCustomPackagingBoxes provide fine quality customized packaging solutions at the most economical prices. We are specialized in providing all sorts of custom boxes whether they are related to candle boxes, hair extensio…
Gable BoxesCandle BoxesCake Boxes
Baton Rouge, LA
We have everything you need to outfit your next special occasion! Theme party decorations, holiday adornments, birthdays, weddings, baby showers, Christmas, Mardi Gras--you name it!
Cake Boxes
Central Islip, NY
Our mission here at Avco Industries is to become the leading pizza and bakery box manufacturer in the nation by providing the highest level of satisfaction to our customers through producing quality product and outs…
Bellefonte, PA
Flour Box Bakery — Welcome
Cleveland, OH
PackagingSupplies.com (Cleveland Packaging, Inc.) is a supplier of packaging and shipping supplies for businesses both large and small. It is run by President, Tim Spicer and Vice President, Jim Stalker. The company carr…
Ziploc BagsPadded Envelopes Newspaper BagsCandy Boxes
Pottstown, PA
Paul Gross founded Albright Paper & Box in 1947 shortly after serving in the Central Pacific during WWII
Candy Boxescosmetic boxesFolding BoxesCorrugated Shipping Containers
Mount Royal , NJ
The Custom Boxes is the leading and pioneer packaging company from Chicago, IL serving thousands of Customers across USA for short & commercial runs. A specialized team working from a decade to serve you better. Make You…
Candy BoxesWholesale Boxes
TheCustomPackagingBoxes, is a leading Packaging and Printing Company that offers high quality, unique, stylish, alluring packaging boxes at most economical rates. As an experienced custom box manufacturer, we provide it …
The custom boxes offers you the high quality custom boxes at affordable rates. They deal in all types of custom boxes so you do not need to go anywhere else. They have a team of professional designers that can design you…
Paper Boxes
Clinton, IA
We price every production run as if it were for one customer getting a price break for volume We share your comments with the supporters of our business The cost of shipping our boxes to a distributor and …
Mak Pakages deals in all types of custom boxes, custom printing,custom packaging box, milk boxes and much more. We handle all your custom packaging boxes and printing needs. Free Shipping and handling within USA
Candy Boxes
Chicago, IL
Www.CakewalkChicago.com was created in 2003 by Lori Parrett to create a renewed interest in homestyle cooking and baking based on "grandma's kitchen" where many of us who enjoy cooking first developed our skills …
Bremen, IN
Indiana Carton Company is a premier manufacturer of paper folding cartons. Our attention to detail and customer service have enabled us to provide complete packaging solutions for over 70 years. We offer innovative and p…
Complete Packaging SolutionsCARTON COMPANY
PackagingSupplies.com has a large selection of packing supplies and shipping supplies at wholesale prices available nationwide. From, jewelry boxes to shrink wrap to mailing tubes, you can buy your discount shipping supp…
Moosic, PA
Northeastern PA Carton Co. is a full service folding carton manufacturer that can take you from concept to finished packaging in a quick, professional and cost effective manner
Candy BoxesFolding Boxes
Taylor, MI
We are here to help you with your candle needs. We offer realistic food candles, seascapes, supplies, step by step projects. We also specialize in wax embeds for gel candles. Our embed wax is a high meltpoint wax made fo…
Toledo, OH
Since 1995 our Mission has been Simple, Help our Many Customers Grow their Business by supplying them with the Highest Quality Containers at a Competitive Price when they need them, develop and strengthen our relati…
lyons, il
A food packaging company in Illinois that specializes in retail bags, fast food, deli, bakery, and salad packaging
Fruit PackagingBakery PackagingPaper BoxesBread Bags
Rocky Point, NY
Tilda's bake shop is located in Rocky Point and has been serving the North Shore of Long Island since 1955.We sell some of our baked goods as well as baking supplies online
cake circlesDecorating Tools
Phoenix, AZ
Our wholesale paper/plastic bags and gift boxes bring a custom feel to in-stock items in a way no other distributor in our industry can. Splash Packaging is home to a fun and diverse inventory of wholesale shopping bags,…
Wholesale BoxesWholesale Shopping BagsWHOLESALE PACKAGING
Paramount, CA
Canton, MI
The Box Depot carries a variety of wholesale bags, boxes and packaging products for business and personal needs.Choose from clear boxes, vinyl bags, ballot boxes, organza, vinyl and other bags and boxes
Gable BoxesCandy BoxesMetal TinsCellophane Bags
West Chester, OH
Honeymoon Paper, manufacturing corrugated, paperboard, and thermoformed boards, boxes, trays, and other paper food packaging for bakery and food service since 1960
Alpharetta, GA
Large selection of Wholesale Gift Boxes, Gift Bags, Wrapping Paper, Candy Boxes and Bags, as well as Wine and Bakery Packaging. Get Great Prices and Excellent Customer Service, we are your One Stop Shop for Wholesale Pac…
Candy BoxesBags And BoxesWholesale Shopping BagsWHOLESALE PACKAGING
buffalo, ny
Enterprise Folding Box Company is a manufacturer of custom industrial packaging. Enterprise also provides die cutting and printing of paper and corrugated products. Since 1965 Enterprise Folding Box Company has focused o…
Cookie BoxesCake BoxesPIZZA BOXES
We welcome everyone, consumer or business large or small, interested in buying better guest packaging that is more convenient, colorful, attractive and unique
Gable BoxesCandle BoxesStretch LoopsCandy Boxes
Fayetteville, NC
Thomas & Howard is a locally owned business specializing in paper goods, bakery supplies, bar supplies and concession items
PABCO Paper produces paper products to serve the building and packaging industries
Can't find Bakery Boxes company near in US? Let us know by adding the missing business here.
Small Business Hub
Sharing tips, ideas and advice to help grow your small business
Hotfrog AdVantage
Hotfrog AdVantage ads appear above the rest in Hotfrog feature pages. By upgrading today your ad will appear in front of potential customers before they notice your competitors.
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
Hotfrog Small Business Hub


text:
8,139 total episodes
Hey thanks for reading my profile glad you liked it :)
I'll take those recommendations you gave me into consideration. I rarely plan out which Anime I plan on watching sometimes I watch a new anime then rewatch one Ive seen again and then new anime again. Sometimes its new new new back to back and sometimes its rewatch rewatch and rewatch. I've been on new new new lately but alas I want to rewatch guardian of the sacred spirit again I've only seen it once and that was quite a bit ago so I'm pretty excited to rewatch it again.
sry :( i did not
hey u just watched kiss x sis did u find a uncensored ep 9 tell me u have

subset: commoncrawl


text:
Need 100 original articles,500 word per article, must be original!
This project received 24 bids from talented freelancers with an average bid price of $239 USD.Get free quotes for a project like this
Project BudgetN/A
Total Bids24
Project Description
I am looking for competent individuals capable of delivering articles on a timely bases and within the agreed deadline. All the articles must meet certain criteria to warranty payment.
This is an easy job, and it does not require any research as all the articles are about cloths.
This is a long term project and currently we need more than 500 articles a week. If you are a team and can provide me with such an amount of articles I will hire you instantly.
Ability to write a 500 word article
Common sense
Article Requirements
All articles must be original(not unique)
No spinned or mechanically written articles( use of software)
All the articles must be at least 500+ words
The keyword must appear 3 times in the article body
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Canadian Superior Energy announced this morning that it intends to file federal and state applications for its Liberty LNG deepwater port proposed for offshore New Jersey in the third quarter of 2010.
Eversheds Sutherland is an international law firm helping the Fortune 100, industry leaders, sector innovators and business entrepreneurs solve their biggest challenges and reach their business goals. Dedicated to unfaltering excellence in client service, we are known for our business savvy and industry intelligence, providing creative and custom solutions for each of our clients. Industry and business experience makes the difference for our clients.
Complete the fields below to send your briefcase via email. Separate multiple email addresses with semi-colons(;)


text: Maria is a Singapore-based writer who spends half her days dieting and the other half making up for it. She has spent most of her life divided between Dubai, the NRI haven for Malayalis and hometown Kerala. Her favourite pastimes are reading and writing fiction and has now added cuddling her adorable baby boy to the list. She is now settled in Singapore, whilst trying to get the hang of eating with chopsticks and pretending to like sushi.


text:
Sony Accessory Case with Cloth for the PSP
by Sony | Item #: 469142 | Model #: 75015 |
We're sorry, this item is not available in your selected Club. Check another Club
About this itemStay clean and organized for your PSP gameplay.
Stay clean and organized for your PSP gameplay. The pouch can store PSP accessories, headphones and more. Use the cloth for optimum appearance and performance. Earphones sold separately.
- Store and protect your PSP system and accessories
- Includes cleaning cloth
Assembled Country
Component Country


text:
I use PhotoEditor. Most of the applications that allow you to edit pictures
also have sev different formats you can save them in.
-----Original Message-----
From: email@example.com <firstname.lastname@example.com>
To: email@example.com <email@example.com>
Date: Monday, July 09, 2001 10:31 AM
Subject: [iris-photos] Re: Stepping Out
>Right now its in a bitmap. I have to try and figure out how to
>convert it to jpeg. Bitmap is way too big.
Your use of Yahoo! Groups is subject to http://docs.yahoo.com/info/terms/


text:
Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease
- Melina Daans1,
- Rik JU Lories1Email author and
- Frank P Luyten1
DOI: 10.1186/ar2518
© Daans et al.; licensee BioMed Central Ltd. 2008
Received: 7 February 2008
Accepted: 24 September 2008
Published: 24 September 2008
Rheumatoid arthritis is a chronic systemic autoimmune disease affecting peripheral joints and leading to loss of joint function. The severity and outcome of disease are dependent on the balance between inflammatory/destructive and homeostatic or repair pathways. Increasing evidence suggests a role for bone morphogenetic protein (BMP) signaling in joint homeostasis and disease.
Activation of BMP signaling in collagen-induced arthritis as a model of rheumatoid arthritis was studied by immunohistochemistry and Western blot for phosphorylated SMAD1/5 at different time points. Expression of different BMP ligands and noggin, a BMP antagonist, was determined on synovium and cartilage extracts of arthritic knees, at different time points, with quantitative polymerase chain reaction. At the protein level, BMP2 and BMP7 were studied with immunohistochemistry. Finally, the effect of anti-tumor necrosis factor-alpha (TNFα) treatment on the expression of BMP2, BMP7, and growth and differentiation factor-5 (GDF5) in synovium and cartilage of arthritic knees was investigated.
A time-dependent activation of the BMP signaling pathway in collagen-induced arthritis was demonstrated with a dynamic and characteristic expression pattern of different BMP subfamily members in synovium and cartilage of arthritic knees. As severity increases, the activation of BMP signaling becomes more prominent in the invasive pannus tissue. BMP2 is present in cartilage and the hyperplastic lining layer. BMP7 is found in the sublining zone and inflammatory infiltrate. Treatment with etanercept slowed down progression of disease, but no change in expression of GDF5, BMP2, and BMP7 in synovium was found; in the cartilage, however, blocking of TNFα increased the expression of BMP7.
BMP signaling is dynamically activated in collagen-induced arthritis and is partly TNFα-independent. TNFα blocking increased the expression of BMP7 in the articular cartilage, possibly enhancing anabolic mechanisms. Different types of source and target cells are recognized. These data further support a role for BMP signaling in arthritis.
Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that affects mainly the peripheral joints. Synovitis with infiltration of inflammatory cells, synoviocyte proliferation, and accelerated angiogenesis triggers the formation of destructive pannus tissue and osteoclast activation that lead to erosion of cartilage and bone with progressive loss of joint function [1]. From a molecular point of view, the severity and prognosis of RA are dependent on the balance between inflammatory or destructive pathways and homeostatic or repair pathways [2, 3]. Molecular signaling pathways, essential for tissue development and growth, such as bone morphogenetic proteins (BMPs), are likely to play a role in tissue homeostasis and repair [4]. However, inappropriate or exaggerated activation of such pathways may also lead to pathology [5–8].
BMPs are members of the transforming growth factor-beta superfamily, a group of structurally related growth and differentiation factors. Their pleiotropic effects on different cell types steer many pre- and postnatal processes, such as cell differentiation, proliferation, adhesion, motility, and apoptosis [9–11]. BMPs were originally discovered as proteins that ectopically induce cartilage and bone formation in vivo [12] and are important during the embryonic development of articular joints [13–16]. Almost 30 BMPs are described and classified into several subgroups according to their structural similarities [17]. Binding of a dimeric BMP ligand to type I and type II BMP receptors typically activates a downstream signaling cascade involving either SMAD family member (SMAD) molecules or mitogen-activated protein kinases. In the classical and most extensively studied pathway, the receptor-ligand complex will phosphorylate the intracellular receptor-SMAD1 and -SMAD5 molecules. These will form a complex with common SMAD4, which translocates to the nucleus, binds to DNA, and directs the transcription of BMP target genes. BMP signaling is regulated at different levels: by ligand diversity, by secreted extracellular BMP antagonists, by inhibitory SMADs, and by nuclear corepressors and coactivators [18, 19].
Different BMPs have been demonstrated in the synovium of RA patients [20–22] but their function and their target cells are not yet clear. BMPs have a chondroprotective role in different animal models of RA [23]. In the present study, we investigated the activation of BMP signaling and expression patterns of different BMP ligands and antagonists in collagen-induced arthritis (CIA). CIA is a well-established mouse model of RA, which develops in susceptible mouse strains following immunization with heterologeous type II collagen (CII) emulsified in complete Freund's adjuvant (CFA) and shares both immunological and pathological features with human RA [24]. Our data highlight the relevance of BMP signaling in the joint and provide a basis for further studies on the role of specific BMPs in RA.
Materials and methods
Animal studies
Eight-week-old male DBA/1J mice were purchased from Janvier Laboratories (Le Genest-Saint-Isle, France). All experiments were approved by the Ethics Committee for Animal Research (Katholieke Universiteit Leuven, Leuven, Belgium). For induction of arthritis, chicken sternal cartilage CII (Sigma-Aldrich, Bornem, Belgium) was dissolved at 2 mg/mL in phosphate-buffered saline (PBS)/0.1 M acetic acid, stirred overnight (O/N) at 6°C, and emulsified with an equal volume of CFA (1 mg/mL) (Sigma-Aldrich). One hundred microliters of the emulsion (0.1 mg of CII) was injected intradermally at the base of the tail. At day 21 after immunization, mice received an intraperitoneal booster injection of 100 μL of CII (2 mg/mL). At day 25, the onset of arthritis was synchronized by an intraperitoneal injection of 100 μL of lipopolysaccharide (500 μg/mL in PBS) (Sigma-Aldrich) [25]. Mice were sacrificed at different time points (day 0, 20, 27, 33, 40, and 47 after immunization) for immunohistochemistry and protein and RNA expression assays. In additional experiments, mice were injected daily with 100 μL of soluble tumor necrosis factor-alpha (TNFα) receptor etanercept/PBS (250 μg/mL) (Wyeth Pharmaceuticals, Louvain-la-Neuve, Belgium) intraperitoneally (or PBS alone as negative control) from day 29 onwards. The severity score was determined daily according to the scoring system of Backlund and colleagues [26]. Mice were sacrificed at day 35.
RNA extraction, cDNA synthesis, and quantitative polymerase chain reaction analysis of synovium and cartilage samples
At each time point and at the end of the TNFα blocking experiment, synovium and cartilage samples were dissected, separated, and used for RNA extraction. RNA was isolated using a Nucleospin RNAII kit (Macherey-Nagel, Düren, Germany) and reverse-transcribed using a Revert-Aid H Minus First strand cDNA synthesis kit (Fermentas, St. Leon-Rot, Germany) according to the manufacturers' instructions. For quantitative analysis, real-time polymerase chain reaction (PCR) was performed in duplicate using the Rotor-gene 6000 detection system (Corbett Research, Westburg, Leusden, The Netherlands). Gene expression of mouse BMP2, BMP4, BMP6, BMP7, growth and differentiation factor-5(GDF5), Noggin (NOG), and TNFα were studied using assay-on-demand primer/probe sets (Applied Biosystems, Lennik, Belgium). Expression was normalized to mouse housekeeping gene GAPDH (glyceraldehydes-3-phosphate dehydrogenase) using the comparative threshold method [27]. In kinetic experiments, data were further normalized to baseline levels.
Protein extraction and Western blot analysis of whole knees
At each time point, three sets of three pooled knees were used for protein extraction. Whole knees were weighed and homogenized (CAT homogenizer X120; CAT Ingenieurbüro M. Zipperer GmbH, Staufen, Germany) in 1 mL of cell extraction buffer (Biosource Europe, Nivelles, Belgium) supplemented with 5% Proteinase Inhibitor Cocktail (Sigma-Aldrich) and 1 mM PMSF (phenylmethylsulfonyl fluoride) (Sigma-Aldrich). Protein extracts were normalized to wet weight in an appropriate volume of cell extraction buffer. Samples were analyzed under reduced conditions (0.1 M DTT [1,4-dithiothreitol]). Samples were boiled for 5 minutes at 95°C, chilled on ice, and loaded onto a 4% to 12% Bis-Tris gel (Invitrogen Corporation, Carlsbad, CA, USA). Electrophoresis was carried out into a commercially available running buffer (NuPage MES SDS Running buffer; Invitrogen Corporation) at 130 V for 10 minutes in the beginning, followed by 25 minutes at 200 V. Proteins were transferred on a prewet PVDF (polyvinylidene difluoride) membrane (Millipore S.A./N.V., Brussels, Belgium) for 70 minutes at 30 V in a transfer buffer containing 0.4 M glycine, 0.5 M Tris base, 0.01 M SDS, and 200 mL/L methanol. Nonspecific binding sites were blocked in Tris-buffered saline/0.1% Tween (TBST) (wash buffer) with 5% milkpowder (BlottoA) (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) for 1 hour at room temperature (RT). Blots were then probed O/N at 4°C with polyclonal antibody against phosphorylated SMAD1/5 (P-SMAD1/5) or SMAD5 (Cell Signaling Technology, Inc., Danvers, MA, USA) (1:1,000 in TBST/5% bovine serum albumin [BSA]) and thereafter incubated with an appropriate horseradish peroxidase (HRP)-conjugated secondary antibody (Jackson ImmunoResearch Laboratories, Inc., West Grove, PA, USA) at a dilution of 1:5,000 in TBST/5% milkpowder for 1 hour at RT. For detection, a chemiluminescent substrate (Western Lightning; PerkinElmer Life and Analytical Sciences, Inc., Waltham, MA, USA) was applied on the membrane. Blots were visualized using an LAS-3000 mini CCD (charge-coupled device) camera using an exposure time of 15 minutes. Densitometry measurements were done using digital image densitometry analysis (ImageJ; National Institutes of Health, Bethesda, MD, USA). As positive controls, mouse mesenchymal progenitor C2C12 cells were stimulated with recombinant BMP2 (300 ng/mL for 30 minutes). As negative controls, blots were incubated with secondary antibody alone (data not shown).
Knees and ankles were dissected, formaldehyde/PBS-fixed O/N, decalcified with Decal (3 days at RT) (Serva, Heidelberg, Germany) or EDTA (ethylenediaminetetraacetic acid) (0.5 M in PBS, pH 7.5) (10 changes at 4°C), and embedded in paraffin. For immunohistochemistry, paraffin sections (5 μm thick) were deparaffinized with Histo-Clear (National Diagnostics, Atlanta, GA, USA) and methanol. For antigen retrieval, sections were incubated 2 hours at RT in 0.1 M sodium citrate/0.1 M citric acid. Endogenous peroxidase was quenched by incubating the slides for 10 minutes in 3% H2O2 in water (BMP7 and P-SMAD1/5) or 3% H2O2 in methanol (BMP2). Sections were washed three times in PBS/0.1% Triton (BMP7 and P-SMAD1/5) or in TBST (wash buffer) (BMP2) and blocked 30 minutes at RT in 20% donkey serum (BMP7, BMP2) or 20% goat serum (P-SMAD1/5) in wash buffer and were incubated O/N at 4°C with primary antibody at a final concentration of 10 μg/mL chicken anti-BMP7 (Pfizer Inc, New York, NY, USA), 2 μg/mL goat anti-BMP2 (Santa Cruz Biotechnology, Inc.), 1:50 dilution of rabbit anti-P-SMAD1/5 (Cell Signaling Technology, Inc.) or with isotype control (chicken, goat, and rabbit IgG) (Santa Cruz Biotechnology, Inc.) or serum (Dako, Glostrup, Denmark) at an appropriate concentration in wash buffer. Sections were then washed three times with wash buffer and incubated for 30 minutes at RT with secondary antibody. For BMP7 immunostaining, the secondary antibody was an HRP-conjugated anti-chicken (Jackson ImmunoResearch Europe Ltd, Newmarket, Suffolk, UK) diluted 1:100. For BMP2 immunostaining, a biotinylated donkey anti-goat at 1:400 dilution was used, followed by streptavidin anti-HRP (LSAB kit) (Dako) (30 minutes at RT). For P-SMAD1/5 immunostaining, an ABC kit (Vecta stain rabbit IgG [Vector laboratories Ltd., Peterborough, UK]) was used for signal amplification. Liquid DAB (3,3'-diaminobenzidine) substrate chromogen system (Dako) was used as a peroxidase substrate. Sections were counterstained with hematoxylin. Adjacent sections were stained with hematoxylin and eosin (H&E). GDF5 immunohistochemistry was not performed on these samples as we found that different commercially available antibodies showed a lack of specificity.
Statistical analysis
Where appropriate (n > 3), results were analyzed with SPSS 15.0 (SPSS Inc., Chicago, IL, USA) with the unpaired non-parametric Mann-Whitney U test. Statistically significant differences were defined as P values of less than 0.05.
Activation of bone morphogenetic protein signaling in collagen-induced arthritis
Kinetics of bone morphogenetic protein ligands in collagen-induced arthritis – mRNA level
Kinetics of bone morphogenetic protein ligands in collagen-induced arthritis – protein level
Effect of tumor necrosis factor-alpha blocking on bone morphogenetic protein expression levels in collagen-induced arthritis
In the present study, we demonstrated a dynamic activation of the BMP signaling pathway, as detected by P-SMADs, in a mouse model of RA, CIA. The activation pattern is dependent on the stage of disease, starting, in the initial phase, at the synovial lining layer, gradually shifting toward the subintimal region and eventually, in the destructive phase, persisting in pannus tissue. Moreover, similar dynamic expression levels were shown for different BMP ligands in CIA. A more extensive study of BMP2 and BMP7, different BMP subfamily members, revealed for both BMPs a distinct and dynamic pattern. In contrast to BMP2, which is restricted mainly to the synovial lining layer and articular cartilage, BMP7 resembles the P-SMAD1/5 positivity pattern very closely (Figure 1). Upon TNF blockade, the expression of BMP7 was increased in the articular cartilage of affected joints, whereas in the synovium the expression levels of BMP2, BMP7, and GDF5 were unchanged, suggesting that at least part of the regulation of BMP expression is TNF-independent. This suggests that, although some BMPs are upregulated under inflammatory conditions, other autocrine and paracrine mechanisms may be important and may sustain BMP expression during the arthritic disease process [3, 28]. In addition, the upregulation of BMP7 seen after anti-TNF treatment, which has an inhibitory effect on cartilage and bone destruction, supports an anabolic effect of TNF blockage. Until now, this association was shown with the Wnt pathway in arthritic mice, in which inhibition of TNF decreased the expression of Dickkopf, a Wnt antagonist, known for its neutralizing effect on anabolic mechanisms while supporting catabolic pathways of joint destruction [29], and with melanoma inhibitory activity in RA patients, a chondrocyte-specific molecule with anabolic characteristics, which has a decreased expression under pro-inflammatory cytokine conditions [30].
Results of earlier studies on BMP expression in RA already speculated on a potential role for BMPs in RA. Our group showed an increased expression of BMP2 and BMP6 in the synovium of RA patients and illustrated their association with apoptosis of synoviocytes [20]. BMP4 and BMP5, however, are reduced in the synovium of RA patients as compared with healthy patients [21]. BMP7 has been demonstrated in the synovial fluid of RA patients and levels are correlated with severity of disease [31]. Marinova-Mutafchieva and colleagues [22] observed BMP type Ia (activin-like receptor kinase-3) receptor-positive mesenchymal cells in the synovium of RA patients, and recently we described different BMP target cells, including mostly fibroblast-like synoviocytes and the vascular-perivascular niche, in synovial biopsies of RA patients [28]. An effective treatment of arthritis resulted in an overall reduction of active BMP signaling. However, the pathway remained active and the relative number of P-SMAD1/5-positive cells did not change, suggesting that indeed part of BMP regulation is inflammation-independent.
Animal models of arthritis are increasingly used to address the role of BMPs in disease pathogenesis. Our group previously studied the role of BMP signaling in joint homeostasis and repair by modulating the BMP signaling pathway in different mouse models of chronic arthritis [23]. NOG haploinsufficiency provided protection for articular cartilage against destruction in methylated BSA-induced arthritis and delayed the progression from cartilage to bone formation in a mouse model of spontaneous ankylosing enthesitis [23] by enhancing BMP signaling. Blaney Davidson and colleagues [32] showed that BMP2 is associated with cartilage protection, chondrogenesis, and osteophyte formation in an animal model of osteoarthritis, and Badlani and colleagues [33] demonstrated that BMP7 protected the articular cartilage in a rabbit model of osteoarthritis, confirming the in vitro pro-anabolic and anti-catabolic properties of BMP7 as proposed by Chubinskaya and colleagues [34] and Fan and colleagues [35]. Overexpression of NOG rendered the cartilage more vulnerable in two mouse models of destructive arthritis (methylated BSA and CIA) [23] and inhibited the onset and progression of remodeling arthritis [8].
In contrast, in these overexpression or genetic models, we have not seen detectable differences in synovitis [23]. Recently, Bobacz and colleagues [36] demonstrated a differential expression of GDF5 and BMP7 in articular cartilage and synovium of hTNFtg mice. They found an increased expression of BMP7 and GDF5 in the synovium of hTNFtg mice along with a decrease of both genes in articular cartilage. Based on their in vitro data, they concluded that a decrease in the cartilage could compromise cartilage repair while an increase of BMP7 and GDF5 in the synovium might contribute to synovial hypertrophy. However, Steenvoorden and colleagues [37] showed that transforming growth factor-beta induced an epithelial-mesenchymal transition-like phenomenon, which apparently precedes synovial hypertrophy, and which can be inhibited in vitro by adding BMP7. Contrasting data also exist on the function of BMP7 in other disease models. In inflammatory bowel disease [38] and acute renal failure [39], BMP7 treatment reduces the severity of the pathogenesis and favors healing. BMP7 inhibits tumor growth in some forms of cancer [40]. In contrast, BMP7 can promote cell invasion and tumor growth [41] and directs cancer to metastasis [42, 43] or exerts malignant fibrinogenic effects [44].
The data presented reveal that BMP signaling is activated during the course of CIA, following a specific pattern, and may be partly independent of TNFα. Furthermore, TNF blocking possibly enhances repair mechanisms via upregulation of BMP7. Our data also confirm that different cells in the synovium and cartilage are a target for BMP signaling. Taken together, the current data suggest a chondroprotective effect of BMPs on articular cartilage, but the biological effect of different BMPs in distinct synovial compartments may be more complex and further functional studies are warranted.
Authors' information
MD is the recipient of a fellowship from the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT Vlaanderen). RJUL is the recipient of a postdoctoral fellowship from the Research Foundation Flanders.
bone morphogenetic protein
bovine serum albumin
complete Freund's adjuvant
collagen-induced arthritis
collagen type II
growth and differentiation factor-5
hematoxylin and eosin
horseradish peroxidase
phosphate-buffered saline
polymerase chain reaction
phosphorylated Smad family members
rheumatoid arthritis
room temperature
Smad family members
Tris-buffered saline/0.1% Tween
- TNFα:
tumor necrosis factor-alpha.
The authors thank Ann Hens for her technical support. This work was funded by the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT Vlaanderen), the Research Foundation Flanders (FWO Vlaanderen) (grant G.0390.03), a GOA grant from KU Leuven, and a Bristol-Meyers Squibb EULAR Young Investigator Award to RJUL.
Authors' Affiliations
- Firestein GS: Evolving concepts of rheumatoid arthritis. Nature. 2003, 423: 356-361. 10.1038/nature01661.View ArticlePubMedGoogle Scholar
- Feldmann M, Brennan FM, Maini RN: Rheumatoid arthritis. Cell. 1996, 85: 307-310. 10.1016/S0092-8674(00)81109-5.View ArticlePubMedGoogle Scholar
- Luyten FP, Lories RJ, Verschueren P, de Vlam K, Westhovens R: Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Best Pract Res Clin Rheumatol. 2006, 20: 829-848. 10.1016/j.berh.2006.06.009.View ArticlePubMedGoogle Scholar
- Lories RJ, Luyten FP: Bone morphogenetic protein signaling in joint homeostasis and disease. Cytokine Growth Factor Rev. 2005, 16: 287-298. 10.1016/j.cytogfr.2005.02.009.View ArticlePubMedGoogle Scholar
- Sancho E, Batlle E, Clevers H: Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol. 2004, 20: 695-723. 10.1146/annurev.cellbio.20.010403.092805.View ArticlePubMedGoogle Scholar
- Hsu MY, Rovinsky S, Penmatcha S, Herlyn M, Muirhead D: Bone morphogenetic proteins in melanoma: angel or devil?. Cancer Metastasis Rev. 2005, 24: 251-263. 10.1007/s10555-005-1575-y.View ArticlePubMedGoogle Scholar
- Yoshikawa H, Nakase T, Myoui A, Ueda T: Bone morphogenetic proteins in bone tumors. J Orthop Sci. 2004, 9: 334-340. 10.1007/s00776-004-0764-9.View ArticlePubMedGoogle Scholar
- Lories RJ, Derese I, Luyten FP: Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis. J Clin Invest. 2005, 115: 1571-1579. 10.1172/JCI23738.PubMed CentralView ArticlePubMedGoogle Scholar
- Hogan BL: Bone morphogenetic proteins in development. Curr Opin Genet Dev. 1996, 6: 432-438. 10.1016/S0959-437X(96)80064-5.View ArticlePubMedGoogle Scholar
- Ferguson CM, Miclau T, Hu D, Alpern E, Helms JA: Common molecular pathways in skeletal morphogenesis and repair. Ann N Y Acad Sci. 1998, 857: 33-42. 10.1111/j.1749-6632.1998.tb10105.x.View ArticlePubMedGoogle Scholar
- Liu Z, Luyten FP, Lammens J, Dequeker J: Molecular signaling in bone fracture healing and distraction osteogenesis. Histol Histopathol. 1999, 14: 587-595.PubMedGoogle Scholar
- Urist MR: Bone: formation by autoinduction. Science. 1965, 150: 893-899. 10.1126/science.150.3698.893.View ArticlePubMedGoogle Scholar
- Thomas JT, Kilpatrick MW, Lin K, Erlacher L, Lembessis P, Costa T, Tsipouras P, Luyten FP: Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nat Genet. 1997, 17: 58-64. 10.1038/ng0997-58.View ArticlePubMedGoogle Scholar
- Luyten FP: Cartilage-derived morphogenetic protein-1. Int J Biochem Cell Biol. 1997, 29: 1241-1244. 10.1016/S1357-2725(97)00025-3.View ArticlePubMedGoogle Scholar
- Polinkovsky A, Robin NH, Thomas JT, Irons M, Lynn A, Goodman FR, Reardon W, Kant SG, Brunner HG, Burgt van der I, Chitayat D, McGaughran J, Donnai D, Luyten FP, Warman ML: Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nat Genet. 1997, 17: 18-19. 10.1038/ng0997-18.View ArticlePubMedGoogle Scholar
- Thomas JT, Lin K, Nandedkar M, Camargo M, Cervenka J, Luyten FP: A human chondrodysplasia due to a mutation in a TGF-beta superfamily member. Nat Genet. 1996, 12: 315-317. 10.1038/ng0396-315.View ArticlePubMedGoogle Scholar
- Ducy P, Karsenty G: The family of bone morphogenetic proteins. Kidney Int. 2000, 57: 2207-2214. 10.1046/j.1523-1755.2000.00081.x.View ArticlePubMedGoogle Scholar
- Massague J, Chen YG: Controlling TGF-beta signaling. Genes Dev. 2000, 14: 627-644.PubMedGoogle Scholar
- Balemans W, Van Hul W: Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev Biol. 2002, 250: 231-250.View ArticlePubMedGoogle Scholar
- Lories RJ, Derese I, Ceuppens JL, Luyten FP: Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum. 2003, 48: 2807-2818. 10.1002/art.11389.View ArticlePubMedGoogle Scholar
- Bramlage CP, Haupl T, Kaps C, Ungethum U, Krenn V, Pruss A, Muller GA, Strutz F, Burmester GR: Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. 2006, 8: R58-10.1186/ar1923.PubMed CentralView ArticlePubMedGoogle Scholar
- Marinova-Mutafchieva L, Taylor P, Funa K, Maini RN, Zvaifler NJ: Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint. Arthritis Rheum. 2000, 43: 2046-2055. 10.1002/1529-0131(200009)43:9<2046::AID-ANR16>3.0.CO;2-8.View ArticlePubMedGoogle Scholar
- Lories RJ, Daans M, Derese I, Matthys P, Kasran A, Tylzanowski P, Ceuppens JL, Luyten FP: Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Arthritis Rheum. 2006, 54: 1736-1746. 10.1002/art.21897.View ArticlePubMedGoogle Scholar
- Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B: Immunisation against heterologous type II collagen induces arthritis in mice. Nature. 1980, 283: 666-668. 10.1038/283666a0.View ArticlePubMedGoogle Scholar
- Terato K, Harper DS, Griffiths MM, Hasty DL, Ye XJ, Cremer MA, Seyer JM: Collagen-induced arthritis in mice: synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen. Autoimmunity. 1995, 22: 137-147. 10.3109/08916939508995311.View ArticlePubMedGoogle Scholar
- Backlund J, Nandakumar KS, Bockermann R, Mori L, Holmdahl R: Genetic control of tolerance to type II collagen and development of arthritis in an autologous collagen-induced arthritis model. J Immunol. 2003, 171: 3493-3499.View ArticlePubMedGoogle Scholar
- Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, Mathieu C: An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods. 2001, 25: 386-401. 10.1006/meth.2001.1261.View ArticlePubMedGoogle Scholar
- Verschueren PC, Lories RJ, Daans M, Theate I, Durez P, Westhovens R, Luyten FP: Detection, identification and in vivotreatment responsiveness of BMP activated cell populations in the synovium of rheumatoid arthritis patients. Ann Rheum Dis. 2008 Feb 14.,
- Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, Heide van der D, Landewe R, Lacey D, Richards WG, Schett G: Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007, 13: 156-163. 10.1038/nm1538.View ArticlePubMedGoogle Scholar
- Vandooren B, Cantaert T, van Lierop MJ, Bos E, De Rycke L, Veys EM, De Keyser F, Bresnihan B, Luyten FP, Verdonk PC, Tak PP, Boots AH, Baeten D: Melanoma Inhibitory Activity, a biomarker related to chondrocyte anabolism, is reversibly suppressed by proinflammatory cytokines in rheumatoid arthritis. Ann Rheum Dis. 2008 Jul 16.,
- Chubinskaya S, Frank BS, Michalska M, Kumar B, Merrihew CA, Thonar EJ, Lenz ME, Otten L, Rueger DC, Block JA: Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfate. Arthritis Res Ther. 2006, 8: R73-10.1186/ar1947.PubMed CentralView ArticlePubMedGoogle Scholar
- Blaney Davidson EN, Vitters EL, Kraan van der PM, Berg van den WB: Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann Rheum Dis. 2006, 65: 1414-1421. 10.1136/ard.2005.045971.View ArticlePubMedGoogle Scholar
- Badlani N, Inoue A, Healey R, Coutts R, Amiel D: The protective effect of OP-1 on articular cartilage in the development of osteoarthritis. Osteoarthritis Cartilage. 2008, 16: 600-606. 10.1016/j.joca.2007.09.009.View ArticlePubMedGoogle Scholar
- Chubinskaya S, Kawakami M, Rappoport L, Matsumoto T, Migita N, Rueger DC: Anti-catabolic effect of OP-1 in chronically compressed intervertebral discs. J Orthop Res. 2007, 25: 517-530. 10.1002/jor.20339.View ArticlePubMedGoogle Scholar
- Fan Z, Chubinskaya S, Rueger DC, Bau B, Haag J, Aigner T: Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1. Clin Exp Rheumatol. 2004, 22: 103-106.PubMedGoogle Scholar
- Bobacz K, Sunk IG, Hayer S, Amoyo L, Tohidast-Akrad M, Kollias G, Smolen JS, Schett G: Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: Potential importance for cartilage breakdown and synovial hypertrophy. Arthritis Rheum. 2007, 58: 109-118. 10.1002/art.23145.View ArticleGoogle Scholar
- Steenvoorden MM, Tolboom TC, Pluijm van der G, Löwik C, Visser CP, DeGroot J, Gittenberger-DeGroot AC, DeRuiter MC, Wisse BJ, Huizinga TW, Toes RE: Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics. Arthritis Res Ther. 2006, 8: R165-10.1186/ar2073.PubMed CentralView ArticlePubMedGoogle Scholar
- Maric I, Poljak L, Zoricic S, Bobinac D, Bosukonda D, Sampath KT, Vukicevic S: Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats. J Cell Physiol. 2003, 196: 258-264. 10.1002/jcp.10275.View ArticlePubMedGoogle Scholar
- Vukicevic S, Basic V, Rogic D, Basic N, Shih MS, Shepard A, Jin D, Dattatreyamurty B, Jones W, Dorai H, Ryan S, Griffiths D, Maliakal J, Jelic M, Pastorcic M, Stavljenic A, Sampath TK: Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. J Clin Invest. 1998, 102: 202-214. 10.1172/JCI2237.PubMed CentralView ArticlePubMedGoogle Scholar
- Notting I, Buijs J, Mintardjo R, Horst van der G, Vukicevic S, Lowik C, Schalij-Delfos N, Keunen J, Pluijm van der G: Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo. Invest Ophthalmol Vis Sci. 2007, 48: 4882-4889. 10.1167/iovs.07-0505.View ArticlePubMedGoogle Scholar
- Rothhammer T, Poser I, Soncin F, Bataille F, Moser M, Bosserhoff AK: Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration. Cancer Res. 2005, 65: 448-456.PubMedGoogle Scholar
- Alarmo EL, Korhonen T, Kuukasjarvi T, Huhtala H, Holli K, Kallioniemi A: Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas. Ann Oncol. 2007, 19: 308-314. 10.1093/annonc/mdm453.View ArticlePubMedGoogle Scholar
- Buijs JT, Henriquez NV, van Overveld PG, Horst van der G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clézardin P, Papapoulos SE, Cecchini MG, Löwik CW, Pluijm van der G: Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res. 2007, 67: 8742-8751. 10.1158/0008-5472.CAN-06-2490.View ArticlePubMedGoogle Scholar
- Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B: Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci. 2007, 52: 3404-3415. 10.1007/s10620-007-9758-8.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Working with Projects - Day 1 - Part 8
Download this episode
This video examines how to create a new project, how to open an existing project, how to close the project, and more. Bob shows where on your computer your project's code resides, and explains how your code is compiled into a .xap file, the contents of a .xap file, and how that file is then copied to the Windows Phone 7 emulator.
Download the source code in c#
Download the source code in VB.Net
Available formats for this video:
Actual format may change based on video formats available and browser capability.
More episodes in this series
Declaring Variables and Assigning Values - Day 1 - Part 9
Related episodes
Part 1 - Series Introduction
Part 2 - Exercise: Writing your First Windows Phone 8.1 App
Part 7 - Understanding the Navigation Model
Part 3 - Introduction to XAML
Part 5 - Overview of the Common XAML Controls
Part 4 - Understanding XAML Layout and Events
UWP-002 - Creating your First Universal Windows Platform App
Part 3: Writing your First Windows Phone 8 App
UWP-003 - Overview of Topics Related to Universal Windows Platform App Development
UWP-001 - Series Introduction
The Discussion
Nice video, cool bit of info about changing .xap to .zip
These videos are great, they make the subject downright fun to learn.
Thank you so much. I was confused about how the .xap files had everything including the images LOL. This cleared it right up thanks!
Comments closed
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


text:
Mississippi mud pie is one of my favorite desserts. I've taken the traditional version and classed it up a tiny bit and also reduced the sweetness just a tad, because while mud pie is delicious, it is sweet beyond compare. :D My love of mud pie originally comes from my stepmother - she makes an amazing one that my siblings and I all go nuts over during the holidays!
This Mississippi mud pie is a great dessert for a BBQ or other potluck style events, because you can assemble it ahead of time and keep it chilled until you're ready to eat it!


text:
The Honourable Justice Peter D Applegarth
Date of Birth
06 August 1958
University Education
- Bachelor of Civil Law, University of Oxford (1985)
- Bachelor of Laws (Hons), University of Queensland (1980)
- Bachelor of Arts, University of Queensland (1978)
Judicial Career
- Judge, Supreme Court of Queensland (2008-)
Pre-judicial Career
- Part Time Member, Queensland Law Reform Commission (2001-2004)
- Member, Faculty Advisory Committee, Queensland University of Technology Foundation Member, Practical Legal Training Advisory Committee, Griffith University (2001-2004)
- Board Member, Legal Aid Queensland (1998-2001)
- Lecturer in Federal Court Practice and Procedure at the Bar Practice Course (1988-2006)
- Practised at the Bar in Queensland (1986-2008)
- Executive Member, Queensland Council for Civil Liberties, including holding office of Secretary and Vice-President (1978-2008)
- Member, Expert Panel to Advise Queensland Government on a new Civil and Administrative Tribunal (2008)
- Chair, Marine Board of Inquiry into the abandonment of an ore carrier in the Gulf of Carpentaria during Tropical Cyclone Nelson (2007)
- Appointed Senior Counsel (2000)
- Associate to the Honourable Justice Spender, Federal Court of Australia (1986)
- Solicitor, Morris Fletcher & Cross (1983)
- Articled Clerk, Morris Fletcher & Cross (1982)
- Associate to the Honourable Mr Justice Macrossan, Supreme Court of Queensland (1981)
- Guest Lecturer in Media Law at University of Queensland, Queensland University of Technology and Griffith University
- Volunteer, Arts Law Centre
- Queensland Editor, Gazette of Law & Journalism
Extra Judicial Positions
- Part Time Lecturer, TC Beirne School of Law, University of Queensland (2008-)
- Member, Faculty Advisory Board, Griffith Law School
- Patron and Board Member, UQ Pro Bono Centre
Biographical Notes
Peter David Talbot Applegarth was born on 6 August 1958 in Brisbane, Queensland. Justice Applegarth attended Brisbane State High School (1971–75), and graduated Bachelor of Arts (1978) and Bachelor of Laws with first class honours (1980) from The University of Queensland.
During this period, His Honour commenced a long period of service as an executive member of the Queensland Council for Civil Liberties (1978–2008). After graduating in law, Justice Applegarth served as associate to Justice Macrossan (1981) and worked as an articled clerk at the Brisbane firm of Morris Fletcher & Cross (1982).
On 1 February 1983, His Honour was admitted as a solicitor of the Supreme Court of Queensland. Justice Applegarth was awarded a University of Queensland travelling scholarship, and undertook two years of postgraduate study at Magdalen College, Oxford (1983–85), graduating Bachelor of Civil Laws (1985). Upon his return to Brisbane, His Honour served as associate to Justice Spender of the Federal Court of Australia (1986).
On 11 August 1986, Justice Applegarth was admitted as a barrister of the Supreme Court of Queensland. His Honour commenced a period of almost 22 years in practice at the Bar in Brisbane, taking silk on 13 December 2000. During his time as a barrister Justice Applegarth was a board member of Legal Aid Queensland (1998–2001), a part-time member of the Queensland Law Reform Commission (2001–04), and served as chairperson of the Marine Board of Inquiry into the abandonment of an ore carrier during a cyclone (2007). Justice Applegarth's practice included a wide range of civil and public law litigation, and His Honour appeared at a number of commissions of inquiry. Justice Applegarth's areas of civil practice included professional negligence, commercial litigation, insurance law and media law
Justice Applegarth was appointed a judge of the Supreme Court of Queensland on 29 August 2008. His Honour served as a Supervised Case List judge in 2010 and as a Commercial List judge between 2011 and 2013. Justice Applegarth resumed duties as a Supervised Case List Judge in 2014.
Complete this request to check if the library contains further biographical details.
Judicial Papers
View papers by, and related to The Honourable Justice Peter D Applegarth


text:
"Our Solution for Poopy Pollution"
Your Subtitle text
Home Page
Where to Buy
The Poopy Carrier ™ is becoming a necessity for all dog owners!
Snap...clip...poopy carrier so YOU don't have to!
As Seen in
Wouldn't it be great to go for a walk with your dog and not have to carry a full bag of poop?
Well, I have something for you! I am a full-time dog walker for "I Love My Happy Dogs" pet sitting service in San Elijo Hills CA and i have come across a few waste filled poopy bags placed aside on the ground. I get it, there aren't trash cans on every corner and who wants to carry a stinky bag of poopy? Not me! So I was inspired to create the Poopy Carrier™.
The Poopy Carrier™ is a small attachment that fits ALL leashes (standard and retractable). It will just about fit on anything such as strollers, back packs, belt loops, and dog collars. It will hold your dogs waste filled poopy bag, so you don't have to. It will help keep our environment clean.
The Poopy Carrier™ will add extra safety to your walks, so you can have both hands readily available if need be.
Sounds Great huh? Yes, it really is!
We now have our new fun and stylish Classic Style polka dot Poopy Carrier that comes in (Red, Black & Pink). All attached with a key ring, two clips for added stability. Our NEW Leash Jewelry line (Black, Pink and Turquoise) is just in time for the new year.
No more waving to your neighbors with a bag of poop in your hands! Hot Item! Get yours before we sell out!
No Stinky Business!
Poopy Carrier™ Dispenser
This handy dispenser gives you no excuses for not picking your doggie's business up. It holds a roll of pick-up bags, key ring
and clips to carry it for YOU after !
Order Today!
(310) 486-1069
Get your Poopy Carrier™ today and enjoy your walks and exercise more now not having to worry where the next trash can is!
Check out our instructional video above.
Order today (310) 486-1069
"Our Solution for Poopy Pollution"
*A Hands-Free way to carry your dogs waste filled poop bags
*Fits ALL Leashes (Standard and Retractable)
*Attaches Easily to leashes, strollers, back packs, belt loops, collars.
*Clip holds multiple bags securely
*Lightweight, comfortable and convenient
*Hygienically recommended
*Environmentally friendly
*Available in many colors & styles
*Classic style Poopy Carrier™ has an attached key ring
*Extra safety with having both hands readily available
Buy Now (310) 486-1069
Snap...Clip...Poopy Carrier so YOU don't have to!
Don't leave home without it!
Buy your Poopy Carrier™ Today!
30 Day Money Back Guarantee!
Promo Code in Video Above
Content copyright ©


text:
1 names.
|Sort by: STARmeter▲ | A-Z | Height | Birth Date | Death Date
|Arnold Schwarzenegger Actor, The Terminator With an almost unpronounceable surname and a thick Austrian accent, who would have ever believed that a brash, quick talking bodybuilder from a small European village would become one of Hollywood's biggest stars, marry into the prestigious Kennedy family, amass a fortune via shrewd investments and one day be the Governor of California!...
1 names.


text:
Report from the KDE version 4 release event
Formally introduced in January, the latest KDE promises new features, improved accessibility, and a regular release schedule.
On January 18, about 200 KDE developers, open source supporters, and journalists gathered in Mountain View, California, to attend the official introduction of the new KDE released the previous week. During his live streaming keynote broadcast to release parties across the globe, project manager Aaron Seigo highlighted the most important new features in KDE.
Later, other developers described additional improvements in the free desktop
during the three-day meeting accompanying the release.
Buy this article as PDF
(incl. VAT)
Buy Linux Magazine
Visit Our Shop
Direct Download
Read full article as PDF:KDE_4.0_Launch_Event_Mountain_View.pdf (93.32 kB)
Munich Plans to Ditch Linux and Go Back to Windows
A major setback for the Linux desktop.
Linux Kernel 4.10 Comes with New Security Features
Improved support for GPU in virtualization.
OpenSUSE Site Hacked
News site for the openSUSE community falls victim to a Wordpress exploit.
LibreOffice Goes Online with 5.3 Release
The source code is available online.
Microsoft Brings Clear Linux OS to Azure
One out of three virtual machines on Microsoft Azure Cloud run Linux.
ASUS Announces a Single-Board Computer
The form factor of the board makes it a drop-in replacement for Raspberry Pi.
Red Hat Releases RHEL 6.9 Beta
Makes it easier for customers to move workloads into container-centric applications.
SUSE Working on a New Operating System Called MicroOS
SUSE's answer to container-centric operating systems.
Biggest Kernel Release Ever
Linux 4.9 is the biggest release in terms of number of commits.
CentOS Linux 7 (1611) Released
The latest version of the official RHEL clone is here.


text:
Posted by ESPN.com's Pat Yasinskas
Thanks to all those who responded to our Your Call post on whether Morten Andersen should be in the Pro Football Hall of Fame and if he'll go in on his first time on the ballot in 2013.
The answers that came to my mailbag were unanimous that Andersen will be a Hall of Famer, but there was some discrepancy over whether he'll make it on the first ballot.
Also, to clarify something that some of you seem a bit confused about: If Andersen goes into the Hall of Fame, it won't be as a Falcon or a Saint. This isn't the Baseball Hall of Fame, where inductees are immortalized wearing a hat with the team of their choosing. In football, you just go in as a player and there's no real team designation.
I picked some responses to share that I thought were representative of what showed up in the mailbag. Here they are:
Nathan in Cary, N.C., writes: Morten Andersen should get into the hall of fame just for putting on a jersey at his age. Plus, to be effective for so long is amazing, and how can you keep the all-time points leader out of the hall?
Keith in Ewing, N.J., writes: As for Morten Andersen, he is absolutely a first-ballot guy. As a youngster growing up in a house where no one was a sports fan, I once remembered my dad saying something about Archie Manning, so I became a Saints fan. When Andersen wasn't re-signed by the Saints, I was so mad (basically because he was their most consistent player for years) that I vowed to become a fan of whichever team signed him. To this day I am a die-hard Falcons fan - see the 6-foot-5 Matt Ryan Fathead I have hanging in my house. Andersen is an icon in two cities. He's an absolute first ballot guy. Thanks again and keep up the great work!
Joseph in New Orleans writes: Morten Andersen is DEFINITELY a HOFer. Is he first-ballot? Sadly, probably not. (Check who else should go in as first-ballot guys.) If he can't, no other specialist will.
Andrew in Atlanta writes: NFL All-Time Leader in total points and has kicked the most field goals with 565. Arguably the best NFL kicker of all time, if not one of the best. He may be a kicker, but look at his entire body of work. He's the all-time leading scorer for both the Saints and the Falcons and leads many NFL records when it comes to kicking and points scored. George Blanda was voted into the Pro Football Hall of Fame in his first year of eligibility, and Morten broke his records for most games played and career points scored. At the end of his career, Andersen was leading in several statistical categories and in many of those, he still is today. Other kickers that have been inducted into the Pro Football Hall of Fame have even had their records surpassed by Andersen. No question, Morten deserves to be inducted during his first year of eligibility.
JT in Nashville writes: Pat- I think Morten Anderson gets in, but probably not on the 1st ballot because of the competition that year. The bigger question is when he does go in, will it be as a Saint or Falcon. Saints fans seem to think he's a lock to go in as a Saint, but his greatest visibility and most famous kick (98 NFC title game)came as a Falcon.
Jim in Ocean Springs writes: Morten is the best NFL kicker, ever. It would be nice to see him and Ray Guy go into the Hall together. Guy is the best punter to ever walk on a football field.
Sazerac in Baton Rouge writes: Thanks for all of your work, Pat! I was in Canton, OH at the HOF last week, and saw that Tom Dempsey's right shoe had made it into the Hall. (I also saw that Deuce's #26 was in a Katrina exhibit). I think Anderson's a shoe-in (forgive me) of sorts, but seeing Dempsey's shoe makes me wonder: does the HOF conscientiously try to feature players that are on the cusp of induction at best when designing exhibits? There seemed to be a compensatory air in the Hall, when weighing all of the players featured in the exhibits against the actual inductees--much to the Hall's benefit IMO--and this made me wonder about the politics regarding the always-a-bridesmaid-never-a-bride type players who are often fan-favorites. I appreciate the role of an actual induction of course, but there seems to be a more complex mission there for the HOF. When is the shoe enough? By the way, Anderson's already in the Danish American Football Federation Hall of Fame--isn't this a potential conflict of interest?


text:
As the school year comes to an end, the District 202 Administration is working to prepare for next year.Superintendent Steve Wilder says budgeting becomes challenging when they get "conflicting information" from legislatures about the funding they will receive.
Wilder tells the WGIL Morning News that it's difficult to begin a budget for next year when the state hasn't confirmed budget numbers yet.
"It's so challenging, the state budget timeline is different than the school budget timeline," says Wilder. "Right now, we're all wanting to start to put hard numbers together and give the Board of Education a little bit of information, so that over the summer we can start to present tentative budgets and finalize things in September. Really as the budget process plays out, and just drags out here in the spring, it just makes it all the more difficult."
Wilder says this will be the first year in his time as Superintendent that the district will end up with a deficit year.
Wilder says they will continue to look for ways to cut costs, but they are just about as efficient as can be.


text:
Our sentences and translations can be used under the Creative Commons Attribution 2.0 license (CC-BY 2.0).
If you love this content, please consider a donation.
TagsView all tags
➜ #328131
➜ #2493202
linked by sharptoothed, 2013-06-12 19:26
Sentence #75586
You cannot translate sentences because you did not add any language in your profile.


text:
Toronto, ONCanada
April 6, 2012
Hola! Bonjour! I'm Romanian, but would like to keep practicing my Spanish and French conversational skills. I live in TO and am a teacher.
Already a member? Log in.
Already a member? Log in.
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


text:
Atarix designs.
I love photoshop and photography!
My biggest talent lies in retouching.
Current Residence: Amsterdam
deviantWEAR sizing preference: M
Favourite genre of music: NL-Rap
Favourite photographer: P0rg
Favourite style of art: Portrait, Sureal and Landscape
Operating System: Win 7
MP3 player of choice: Iphone
Wallpaper of choice: Landscape
Favourite cartoon character: a lot
Personal Quote: If you have


text:
Beautify, sculpt, and adorn your long hair with Spellstone hand carved hair sticks designed by Alex Morgan. These are hand carved in Viet Nam of domestic water buffalo horn, some with abalone inlay. The hair sticks are about 7" ( 16 cm) long depending on design. They will arrive in a gift box, ready to present to someone you love, or as a gift to yourself for a special occasion. Every one has a blessing implicit in the design. Spellstone hair sticks are designed and crafted exclusively for Mehandi.com!
Click shopping cart buttons below to order.
Water buffaloes are domestic farm animals across Asia. They are loved as a working member of the family and valued as a tractor or family car. Water buffaloes are never killed or harmed to just harvest their horns. When a farmer's water buffalo dies at the end of a long and productive life, all parts, including the horns, are harvested and put to good use so nothing is ever wasted.
About Water Buffalo Horn
Symbol of Mystery and Emotion
Octopus can change its shape to fit through the smallest opening. It lives in the deep watery realm of emotion, and brings dexterity and the ability to adapt. Octopus will help you see your way through murky emotional situations.
Octiva (the octopus) black horn hair ornament = $25.99 #7141
the Lady of the Rivers NEW!
Oshun is the spirit who rules love, maternity and marriage. Bind your hair with this symbol of Oshun to celebrate the grace, beauty, and benevolence of the creative force of the world.
Oshun: black horn hair ornament = $25.99 #7153
Goddess of Abundance and Wealth NEW!
Lakshmi helps you move to an awareness of the richness that surrounds you.
Lakshmi: black horn hair ornament = $25.99 #7151
Lakshmi: amber horn hair ornament = $25.99 #7152
A Blossom in the Garden of Paradise
The garden of paradise holds peace and abundance, as well as the knowledge of good and evil, wisdom and language. The blossom symbolizes the potential for new growth, new wonders, new knowledge.
Arabesque pale horn hair ornament = $25.99 #7124
Arabesque black horn hair ornament = $25.99 #7123
Welsh mythological figure
Goewin brings assistance when it's needed, and helps transform negative experiences into positive outcomes.
Goewin pale horn hair ornament = $25.99 #7128
Goewin black horn hair ornament with abalone inlay = $25.99 #7127
Lotus Flower:
Purity and Enlightenment
Lotus is rooted in mud, and rises through murky water to blossom in the sun, releasing perfume into the air. Thus it symbolizes the journey to realization of your natural enlightened state, beyond illusions of limitation and separateness.
Lotus Flower pale horn hair ornament = $25.99 #7136
Lotus Flower black horn hair ornament = $25.99 #7135
Bellona: Warrior Goddess
She embodies military virtues - loyalty, valor, discipline – and the strength to fight whatever battles come your way.
Bellona pale horn hair ornament = $25.99 #7126
Bellona black horn hair ornament = $25.99 #7125
|Visit Spellstone Carved for more pictures!
These ornaments are Spellstone designs
by Alex Morgan exclusively for Mehandi.com
In the Odyssey, polished horn is symbolic: true dreams and visions pass through gates of polished horn (book 19, lines 560-569)


text:
Tuggeranong Vikings Baseball ClubSports Baseball Clubs
Mcbryde Crescent, Wanniassa, ACT 2903
Best match results for: CATEGORY = Baseball Clubs for Kids + LOCATION = the Tuggeranong Region
Mcbryde Crescent, Wanniassa, ACT 2903
Kambah No 2 Oval, off Laidlaw Street, Kambah, ACT 2902
In addition to the results above, we also have included a selection of related kids activities that may interest you.
Baseball clubs for kids around the Tuggeranong Region
100 Hawkesbury St, Farrer, ACT 2607
Crowder Cct, Stirling, ACT 2611
3 Narupai Pl, Narrabundah, ACT 2604
Cnr Bindubi St & Belconnen Way , Sainsbury & Walford Memorial Diamond , Aranda, ACT 2614
Wakefield Ave , Majura Oval , Ainslie, ACT 2602
Baseball activities for kids around the Tuggeranong Region
100 Maitland Street, Hackett, ACT 2602
Kyeema Street, Narrabundah, ACT 2604
Ball sport activities for kids in the Tuggeranong Region
Chrinside Circuit, Kambah, ACT 2902
2 Lynn Ave, Gordon, ACT 2906
798 Were St, Calwell, ACT 2905
Drakeford Drv, Kambah, ACT 2902
13 Hurtle Avenue, Bonython, ACT 2905
Kambah Pool Rd, Kambah, ACT 2902
6 Jenke Cct, Kambah, ACT 2902
PO Box 6278, Wanniassa, ACT 2903
P.O. Box 4997, Chisholm, ACT 2905
Were Street, Calwell, ACT 2905
Proctor St, Chisholm Oval, Chisholm, ACT 2905
56 Coyne Street, Fadden, ACT 2904
Castleton Crescent, Gowrie, ACT 2904
Proctor Street, Chisholm, ACT 2905
14 McCulloch St, Kambah, ACT 2902
Soward Way, Tuggeranong, ACT 2900
Drakeford Drive, Kambah, ACT 2902
Were Street, Calwell, ACT 2905
Hyland Place, Wanniassa, ACT 2903
Po Box 48, Wanniassa, ACT 2903
Ball sport activities for kids around the Tuggeranong Region
Po Box 699, Marist Rugby Club, Mawson, ACT 2607


text:
|Best Selling
|Home & Family
|Money & Employment
|Sports & Recreation
|Bargain Ebooks
|Choose a Subcategory below:
|Diet (46)
|Fitness (44)
|Spiritual Health (39)
|Womens Health (49)
|Nutrition (49)
|Beauty (54)
|Mental Health (45)
|Alternative (54)
|Remedies (32)
|Addiction (39)
|Medicine (46)
|Cooking Recipes (18)
|New Products (39)
|Popular Tags: Weight Loss (31) Cancer Care (5) Fat Loss (4)
|Home >> Health >> Nutrition >>
|During the past decade or so, society has once again become increasingly aware of what an important part nutrition plays in the health of the human body. Fighting cancer, preventing diabetes, relieving depression -- proper nutrition can literally perform miracles. No matter what your physical needs may be, eBook Explorer has nutrition ebooks that can help you get the most out of your diet. Some of our most popular nutrution ebooks include:
|Why Do You Overeat? Get The Answer Now - This book contains the 300 pages of original content by Zoe Harcombe. It explains, in detail, the medical conditions that cause you to overeat, what you CAN DO to overcome them and how to get your eating back in control. The bottom line is that you overeat because you are a food addict. You know that your cravings for food are so bad that all the will power in the world can't stop you eating certain foods. If only you could get rid of those cravings you could stick to a diet and lose weight.
|eBook: Lower Cholesterol Naturally - The information given in this eBook can help lower your total cholesterol level and LDL cholesterol level, and raise HDL cholesterol, and control triglycerides naturally without medication. It shows you the ways to lower cholesterol naturally: -The eBook gives a list of heart friendly low cholesterol foods and low fat vegetarian recipes that will help lower your cholesterol. These recipes use ingredients that are high in soluble fiber, beta caroteine, potassium, calcium, etc. -If you are on cholesterol lowering medication, you can continue with it and use the information in this eBook to lower its dose. -When you are eating foods recommended in this eBook and follow the tips, you should get checked your blood cholesterol level measurements periodically because you may not be required to take medication after some time, you may be approaching to normal levels of cholesterol. -The recipes given in this eBook are all low fat, and are useful to people of all ages including children and seniors, irrespective of their cholesterol levels. -Protect your heart, prolong your life. -Tasty & nutritious healthy recipes.
|Matches: 62 Pages: First 1 2 3 4 Next Last
|Featured Nutrition Ebooks
|Site Screen Shot
|Matches: 62 Pages: First 1 2 3 4 Next Last
|home | articles | search ebooks | free ebooks | bargain ebooks | about us | author login | feedback
Ebook ExplorerAll rights reserved. User Agreement | Privacy Policy
244 5th Avenue, # J-229
New York, NY 10001
Copyright 2003-


text:
Several San Francisco area school districts are complying with a requirement in NCLB stipulating that Title I schools hire only "highly qualified teachers." Mount Diablo Unified School District, for example, has been successful in reducing the number of its unqualified teachers by using Web searches and creating teacher intern programs with nearby colleges.
Full Story:San Francisco Chronicle


text:
Russia's Not Bound to Assad, Syria Opposition Head SaysSangwon Yoon and Henry Meyer
Russian Foreign Minister Sergei Lavrov has assured the Syrian opposition that his country isn't committed to President Bashar al-Assad, the leader of the main anti-government coalition said.
"When I met Lavrov last week in Paris, he confirmed that Russia isn't holding on to Assad," Ahmad al-Jarba, the head of the Syrian National Coalition, told reporters yesterday in Geneva.
Jarba said Russia, one of the Assad regime's major allies, has no say in how Syrians should end their civil war. "The solution lies in negotiations between the Syrians in Geneva," he said.
The Syrian opposition is scheduled to begin talks with representatives of the Assad government today, the first negotiations since a conflict that has killed more than 130,000 people erupted three years ago. The United Nations is mediating the discussions in Geneva, trying to bring the two sides face-to-face.
The talks are an effort to implement a 2012 plan -- known as the Geneva I communique -- to form a transitional governing body with full executive powers, which would include control over the military and security and intelligence services.
Russian Foreign Ministry spokeswoman Maria Zakharova couldn't immediately be reached for comment on Jarba's statement.
'Blood on Hands'
Lavrov's comments, as related by Jarba, aren't inconsistent with what he has told U.S. Secretary of State John Kerry, according to a State Department official who asked not to be identified discussing diplomatic communications.
The opposition maintains that Assad can have no role in a transitional government, a position supported by the U.S. and its European and Arab allies, including Saudi Arabia.
Kerry said yesterday that members of the Assad government "who don't have blood on their hands" can be part of the political transition.
"But in the end, because the Geneva I communique requires a transition government by mutual consent, there is no way that the opposition is ever going to consent to Assad being part of that future," Kerry said in an interview with Al Arabiya TV.
Russia has disputed that view, contending that a political transition in Syria doesn't mean "regime change," and that negotiations are necessary to reach any agreement on Assad's future.
'No Reason'
Assad said his chances of running in Syria's June presidential elections are "significant," and he sees "no reason why" he shouldn't, according to a Jan. 20 interview with Agence France-Presse news agency.
"I must be at the forefront of those defending this country, and this has been the case from day one," he said.
Jarba said he couldn't predict how long the negotiations would last, saying that a detailed timetable would be discussed today.
"Negotiations will definitely be difficult," he said. "The road of a thousand miles starts with a step."
Syria's civil war, which has forced millions to flee their homes, has spread across borders, fueling sectarian violence and political instability from the Mediterranean Sea to the Persian Gulf.
It has seeped into neighboring Iraq and Lebanon, where a car bomb killed five people on Jan. 21 in the stronghold of the Iranian-backed Hezbollah, a Syria ally fighting alongside Assad's troops. The violence was the latest in a string of attacks against the group for its role in the crisis.
Sunni extremist groups, some of them affiliated with al-Qaeda and the uprising in neighboring Iraq's Anbar province, have assumed a larger military role in the opposition, prompting Assad and his allies to portray the uprising as a war against terrorism.


text:
Where can I obtain information about radon in my area?
Each state has a radon program and contact, from which you can obtain information. While a map of radon zones show some areas to have lower levels than others, the U.S. Surgeon General encourages all homeowners to test their homes.
Learn more:
Indoor Air Quality Publications & Resources
Health risks of radon


text:
May 23, 2012
Some acroyoga friends came over to the CAM activity room on Tuesday night. In case it's unclear, I'm the one in the purple pants.
Google, May 22, 2012 (10)
View album
7 plus ones
2 comments
no shares
Shared publicly•View activity
- I love the double shoulder stand! How did you get into that?May 24, 2012
- +Laura Costello that was a puzzle for us too! Our solution: the person on the base's feet got up first, and stayed there (holding onto the base's shins for stability) while the other person did a heavily assisted cartwheel onto the base's hands. Once that was stable, the flyers were able to transition to take each others' arms, and the spotter was safely able to go get the camera.May 26, 2012


text:
- Hi there, welcome to Tribesmart. Log in to get started...
Teal Bone Bead Bracelet
Guide price: £27
Last updated on 25th Jun 2009
Tags: manumit
Teal Bone Bead Bracelet
Handmade by artisans in India this beaded bracelet is bright & fun. Recycling otherwise wasted materials.
Login or Register to add this to your wish list or favourites.
Similar to Teal Bone Bead Bracelet
Buddha Bracelet
This Buddha face bracelet is unique in terms of look and colour. The blue Buddha head is contrasted beautifully with the orange tassle. You don't need any other accessory when you have worn this bracelet.
Monogram Bracelet in18K Gold Plated Silver
Go with this 18k yellow gold plated sterling silver monogram bracelet and wear your custom style anywhere! Beautifully hand-crafted with a monogram charm and a rollo chain, this classic monogram bracelet is a stylish choice for adding a personal touch to any outfit.
5.25" Fleur- de -Lis Charm Bracelet - monkey
5.25″ toggle bracelet with fleur- de -lis charms. .925 Sterling Silver Find more info at: http://www.monkey-hill.com/product/5-25-fleur-de-lis-charm-bracelet/
Steriling Silver 925 CZ Teardrop Bracelet
We take immense joy by inviting you to discover our exotic sterling silver rhodium plated bracelet collection at incredible price online with us. We give unmatched price deals on finely crafted jewelry by talented artisans.


text:
The mission of the Writing Center is to meet not only the needs of students, but those of all writers across the university. In order to attract a strong community of faculty/staff writers, we offer a number of services for use in their classrooms and with their own writing.
Click the link to view our Scholarly Writing Initiatives for Faculty & Staff flier. This will provide more details on ways in which the Writing Center aims to support Faculty/Staff writers at GVSU. Feel free to print a copy for your office, a colleague, or save it to your computer for future reference.
Join your colleagues for quiet writing time most Friday afternoons. These events integrate all aspects of our faculty/staff writing support, giving you an opportunity to work in peer writing groups, work one-to-one with a professional consultant, or write in a quiet space.
This scheduled, free-from-distraction writing time helps you to make steady progress on a writing project and benefit from the focus and support that comes from writing among your colleagues
Scroll down the page for up-coming dates and locations.
Structured as writing time with opportunities for individualized feedback, these 5-day retreats are an opportunity for faculty and staff to make extraordinary progress on a long writing project -- or several shorter ones. Writing center representatives will facilitate the retreats and be available to provide feedback to participants.
We'll provide a work station, light snacks, and plenty of coffee and tea; you bring the materials you'll need to be productive on your writing project and your own laptop.
Patrick Johnson, Director of the Writing Center, and/or Lindsey Ellis, Director of Writing Across the Curriculum, will be on hand to provide feedback if you'd like a personal consultation about your project.
Scroll down the page for up-coming dates and locations.
Faculty/Staff Writing Groups:
Meet with a small group of your colleagues from across campus to share drafts of your writing for feedback. For more information, feel free to contact us with your questions and/or requests.
Click here to view our Scholarly Writing Initiatives for Faculty & Staff flier for details.
Faculty/Staff One-to-One Consultations:
Meet with a peer writing consultant online or in person to receive constructive feedback on your writing. For more information, feel free to contact us with your questions and/or requests.
Allendale Dates
Allendale Locations
September 16
LOH 227 (Conference room) @ 12pm-3pm
September 30
LOH 227 (Conference room) @ 12pm-3pm
*October 14
*LOH 167 (Classroom) @ 12pm-3pm
Downtown Dates
Downtown Location
September 23
Eberhard Center, Room 101 @ 12pm-3pm
October 7
Eberhard Center, Room 101 @ 12pm-3pm
October 21
Eberhard Center, Room 101 @ 12pm-3pm
Q: What happens at the writing center on Faculty/Staff Fridays?
A: A whole lot of writing! The idea behind the event is that by setting aside time to write away from the interruptions of your home or office, and in a space conducive to writing, you will actually get some writing done. The silent support of hard working colleague-writers around you is motivating. And the writing center has what you need--style guides, books about writing, a faculty/staff writing consultant, food, and beverages--to keep you productive and comfortable.
Q. Can I come late or leave early?
A. Absolutely!
Q. Do I need to make a reservation?
A. Nope! Just show up ready to write.
Q. I can't fit Fridays into my schedule this year. Will you do this next academic year?
A. So far, signs point to "yes," but watch this page for more info. You might also be interested in participating in one of our week-long writing retreats, which are held in May and August each year.
Allendale, Lake Ontario Hall Room 120
March 8-10 (Spring Break), 2017
Allendale, Lake Ontario Hall Room 120
May 1-5, 2017
Downtown GR, Eberhard Center
August 7-11 2017
Registration Information:
Please submit your registration form by April 21 (for summer retreats). Please note that while faculty working on dissertations will be given first priority in registering for the retreat, there will likely be plenty of room available to faculty and staff working on other projects.
Patrick Johnson, Director of the Fred Meijer Center for Writing, & Lindsay Ellis, Director of Writing Across the Curriculum, will facilitate the retreat, which runs from 9 a.m. until 5 p.m. each day.
The Center will provide a laptop computer for your use, as well as writing resources and goal-setting activities to keep you focused.
The Center will ensure you're well nourished and alert by providing snacks and drinks throughout the day and lunch at noon.
Participants are expected to spend at least seven hours per day on writing or writing-related activities and join other participants for lunch each day.
Form to be filled out ahead of the retreat to help participants gather their ideas and materials and show up ready to write. Daily Reflection Form
Form filled out by participants at the end of each day to keep track of what they accomplished and where to pick back up in the morning. Resources and Reminders
Guides participants to online and bookshelf resources, as well as other writing support. Retreat Evaluation Form
Participants tell us what they think of the retreat.
And here are some links to great pieces about writing as a faculty member:
Have other questions? Stop in and visit! Or call us at 331-2922.


text:
What does MU mean?
Miss You
Other definitions of MU:
All of our slang term and phrase definitions are made possible by our wonderful visitors. If you know of another definition of MU that should be included here, please let us know. Keep scrolling and fill out the form below!
How to use the term MU:
There are no example uses of MU at this time. We would greatly appreciate your contribution if you would like to submit your own!


text:
Students - Participate!
Want to spend time learning first-hand what a typical workday is like for alumni and parents in various career fields?
Offered every January during winter break, job shadowing provides one-day experiences in which students shadow alumni or parent volunteers in the workplace as they go about their day's work. Job Shadowing is open to students of all class years! Students must apply to participate and will be matched based upon their top selections and relevant career interests. Please see application timeline below.
Alumni, Parents and Friends - Volunteer!
Inspire a student's career! Share your workplace and career insights by volunteering to be a job shadowing host. Learn more on our FAQs for Hosts (pdf) and register by October 21 to host a Job Shadow! Contact Tiffany Kurzawa, firstname.lastname@example.com, Assistant Director for the Center for Career Development, to learn more about the program.
Sampling of Shadowing Sites
- Jersey Shore Medical Center - Neptune, NJ
- Credit Suisse - Boston, MA
- A+E Networks - New York, NY
- U.S. Attorney's Office - Alexandria, VA
- Sen. John Heinz History Center - Pittsburgh, PA
- Clear Channel Outdoor - Philadelphia, PA
- NorDx Laboratories - Scarborough, ME
- BNY Mellon - New York, NY
- U.S. Dept. of Homeland Security - Fairfax, VA
- Reading Hospital & Medical Center - West Reading, PA
- Elementary, Secondary & Higher Education - Various locations
Funding Assistance
Limited funding is available for those students who need assistance with transportation costs in order to participate in the program. Students who will travel greater than 35 miles can apply for funding after they have been accepted for an opportunity.
Questions? Contact Rebecca Barth, firstname.lastname@example.com, Administrative Services Assistant.
January 2017 Job Shadowing
Shadowing Timeframe: One day January 9-20
Applications Available: Week of October 24
Applications Due: November 6 by 11:59p.m.
Students Notified: Before Thanksgiving Break
Students Decisions Due: November 28 by Noon
Mandatory Job Shadowing Preparation Workshop for Participants: Weeks of November 28 & December 5
*Students who are studying abroad at the time of the session will be sent information via email.


text:
Parayso Tulum Beach Hotel
Property Location
With a stay at Parayso Tulum Beach Hotel in Tulum, you'll be on the beach and minutes from Ziggy Beach. This beach hotel is within the vicinity of Playa Paraiso and Cenote Crystal.
Treat yourself to a stay in one of the 8 guestrooms, featuring private pools. Your room comes with a Select Comfort bed. Rooms have private balconies. Conveniences include complimentary bottled water and a turndown service, and housekeeping is provided daily.
Enjoy recreation amenities such as an outdoor pool or take in the view from a garden. Additional amenities at this hotel include complimentary wireless Internet access, shopping on site, and wedding services.
Satisfy your appetite at a coffee shop/café serving guests of Parayso Tulum Beach Hotel.
Business, Other Amenities
The front desk is staffed during limited hours. Self parking (subject to charges) is available onsite.
Property Amenities
- Accessible bathroom
- Beach sun loungers
- Beach towels
- Beach umbrellas
- Coffee shop or café
- Free WiFi
- Front desk (limited hours)
- Garden
- In-room accessibility
- Long-term parking (surcharge)
- Number of buildings/towers - 2
- Number of floors - 2
- Outdoor pool
- Outdoor seasonal pool
- Parking (limited spaces)
- Self parking (surcharge)
- Shopping on site
- Smoke-free property
- Total number of rooms - 8
- Tours/ticket assistance
- Wedding services
- Year Built - 2007


text:
Yoshizilla-Rhedosaurus: Well, thanks to /vp/, I made this as a request. Will I update that certain /vp/ fanfic? maybe, but for now, I got a lot of writing to do.
Disclaimer: Everything belong to their owners.
Serperior was hanging around in some random, perfectly smooth grassy meadows with his bro Krokorok, both of them simply enjoying the pleasure of walking around. However, Serperior felt something, a disturbance in the force. Krokorok scratched his head as he walked forwards, confronting Serperior and asking what was happening.
"Hmmhmmhmm... I have this... strange feeling..." Serperior mutrered as he rubbed his chin with his tail.
"What's up, Serperior?" Krokorok asked as he opened up his arms together.
Serperior frowned as he glanced behind him, then looked at Krokorok. "Well, croco mah boi, it's just... you see that Lilligant nearby?"
Krokorok turned behind, seeing the Lilligant that Serperior mentioned. "Yeah, what about her?"
Serperior smirked as he looked up, his tail moving slyly. "Well... let's just say... I got these... feelings for her..."
Krokorok chuckled, folding his arms together. "Oooh, the feeling for love?"
"Love?" Serperior remarked as he blinked several times.
Krokorok moved his hands in a slow motion. "You know, when you feel warm, cuddly, cozy..."
Serperior chuckled nervously as he rubbed his neck. "Oh. That. Well..." He sighed as he looked up, looking at the white, puffy clouds above. "I could go ahead with it, but I would look odd... don't you think?"
Krokorok laughed as he waved his hands, reassuring Serperior. "Don't worry about it! I'm behind you one hundred percent!" He then jumped into the bushes, popping his head out as he gave Serperior a thumbs up. "Go for it, mah boi!"
Serperior sighed as he slithered forwards, gulping as he had doubt in the back of his mind.
Lilligant was sitting on the nice, smooth grass, looking up at the clear blue sky with a cheery smile across her face. Lilligant's stomach growled loudly, causing Lilligant to blush in embarrassment as she rubbed her stomach with both her leafy arms, unaware of what was going to happen. Serperior then wrapped his long scaly body around Lilligant, squeezing her. Lilligant screamed in shock as she was caught by surprise.
"What the- gah!" Lilligant tried breaking free, but she panted several times, still struggling to get out. Serperior's grip got tighter, prompting Lilligant to give up as she sighed, feeling exhausted. Serperior chuckled as Lilligant looked up, still shocked.
"I like that you still tried giving it your all after I squeezed you." Serperior commented as he winked at Lilligant. "I can appreciate that."
Lilligant shook her head as she pulled her arms out, pouting, "You appreciate that? You came out of nowhere and tightened me like a rag doll!"
Serperior chuckled as he snarkly remarked, "Ohoho, but I haven't even came. In fact, I was thinking of that later..."
Lilligant's blush got bigger as her jaw dropped. "Wha- are you hitting on me?"
Serperior shook his head as he was caught by surprise. "Nononono! It's just that... ugh..." He then closed his eyes, muttering to himself, "Damn it, I'm really letting myself go. Who writes this drivel, anyway?"
Back in the bushes, Kokorok glanced next to him, to see a Scrafty typing on a laptop. Krokorok shrugged as Serperior groaned, rolling his eyes.
Lilligant pushed Serprerior off of her, heading towards the western direction as she folded her arms, degrading Serperior, "Humph! If I wanted to get a date, I would be kidnapped every single day of my life!"
Suddenly, right on the spot, she was snatched by a quick, sinister Cofagrigus, who laughed as he tightened his grip on Lilligant. Lilligant screamed in horror and pain as Serperior gasped, rushing towards Lilligant's aid.
"This is ridiculous! I just got crushed, and now I'm crushed again!" Lilligant demoaned as she struggled.
The Cofagrigus laughed as he poked Lilligant, taunting her, "Don't bother moving, my dear. Soon, the seven Chaos Pokeballs will be mine, and I will make the Cofagrigus Empire! Ohohohoho!" He then disappeared underneath the earth, taking Lilligant with him, who screamed for her life.
Serperior gasped in shock, looking at Krokorok, who didn't have anything to contribute. Serperior turned around, squinting his eyes as he muttered heroically, "There's only one thing to do..."
He then started sucking on his tail, wheeling back and forth as Krokorok facepalmed.


text:
This is News - Special Report Category
Demonetisation & You
Demonetisation & You - 50:00:00 Mins
This is News - Special Report Category
World is One Degree
World is One Degree - 333:20:00 Mins
This is News - Special Report Category
News Room Live
News Room Live - 50:00:00 Mins
This is News - Special Report Category
Kalinga Helpline
Kalinga Helpline - 50:00:00 Mins
Experts help people solve their personal and professional problems by suggesting the right course of action to them.
Infosys Report Card
Infosys Report Card - 50:00:00 Mins
Take a look at all the latest updates and developments regarding Infosys, an Indian multinational corporation.
The Lead With Jake Tapper Live
The Lead With Jake Tapper Live - 166:40:00 Mins
Host Jake Tapper presents the day's biggest political, economic, social, cultural and sports headlines from around the world.
Entertainment - 50:00:00 Mins
Entertainment-based programme.
Saara Desh-100 Khabrein
Saara Desh-100 Khabrein - 50:00:00 Mins
An expert gives the latest news and updates about the happenings in the country.
CNN Today
CNN Today - 50:00:00 Mins
The most recent news, updates and developments.
Ravana - 50:00:00 Mins
Ravana, a devotee of Lord Shiva, captures the island country of Lanka after taking it forcefully from his half-brother Kubera.
Traders 20
Traders 20 - 50:00:00 Mins
Technical experts give 20 fresh stock recommendations from which the viewers can benefit. They also showcase commodity picks and strategies to make th
Rahasya Lok
Rahasya Lok - 50:00:00 Mins
Take a look at different mysterious incidents and stories that take place in the state of Rajasthan.
24 Taas Special
24 Taas Special - 50:00:00 Mins
Coverage of the latest news, updates and developments from around the country.
India Today India Tomorrow
India Today India Tomorrow - 50:00:00 Mins
The host presents a report on the growth of India in different sectors, comparing the country's current and future developmental goals.
This World
This World - 83:20:00 Mins
This program is an international investigative documentary series.


text:
This grey cardigan with added shoulder zips is a smart way to make a statement. This easy-chic cardigan will quickly become a go-to knitwear option. Show off the flattering drapes over a pencil skirt or jeggings on a spring day.
Length: 65cm
Product Code: S15D/KC09/02RF
I'm Made Of: 50% Cotton, 50% Acrylic
Look After Me: Hand Wash


text:
Artichoke Hearts
(Recipe Collection)
1 Recipe Created by LITTLELETA
Recipes in this Collection
Stepf's Zucchini "Pasta" with Tomatoes and Basil "Cream"
This "pasta" dish is so light and yet rich--you'll never guess the "cream" is made from sunflower seeds. The white beans add buttery flavor and protein. Make this when the garden overflows with tomatoes, basil and zucchini.Submitted by STEPFANIER
Carbs: 34.6g | Fat: 5.1g | Fiber: 13.3g | Protein: 12.5g | Calories: 211.4
Send this recipe collection to a friend - https://recipes.sparkpeople.com/cookbooks.asp?cookbook=518744


text:
Is Sky Screamer incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
Are these details correct?
Hotfrog NewZealand provides information regarding Sky Screamer in Auckland. Sky Screamer is located at Albert Street, Auckland Auckland 1010 and provides Sports and Recreation services. Contact them on 0800 932 8649 or by visiting them on their website http://www.skyscreamer.co.nz.
Is Sky Screamer in Albert Street, Auckland Auckland 1010 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
We have more Sports and Recreation services in Auckland available on Hotfrog NewZealand. You can update your search for Auckland Sports and Recreation by location, keyword or service options.
14 Waione Avenue Te Atatu Peninsula Auckland
Shop 4, The Zone 14 - 28 Subway Road Auckland 2120
Level 12 45 Queen Street Auckland 1010
Unit A, 331 East Tamaki Road Auckland 2141
Small Business Hub
Sharing tips, ideas and advice to help grow your small business.
Your profile without ads
Have you considered upgrading to Hotfrog AdVantage? No competitor advertising means exclusive focus on your business. You take centre stage.
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
Hotfrog Small Business Hub


text:
Is Produits Architecturaux Celesta Inc incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
Are these details correct?
Hotfrog Canada provides information regarding Produits Architecturaux Celesta Inc in Hudson QC. Produits Architecturaux Celesta Inc is located at 114 Reid Rue, Hudson QC J0P 1H0 and provides Retail services. Contact them on (450) 458-3311.
Is Produits Architecturaux Celesta Inc in 114 Reid Rue, Hudson QC J0P 1H0 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
We have more Retail services in Hudson QC available on Hotfrog Canada. You can update your search for Hudson Retail by location, keyword or service options.
Lancaster Place 61 Cameron, Suite 210 HUDSON QUEBEC J0P 1H0
736 rue Main RR 2 HUDSON QUEBEC J0P 1H0
500 Rue Main, Suite 202 HUDSON QUEBEC J0P 1H0
Small Business Hub
Sharing tips, ideas and advice to help grow your small business
Your profile without ads
Have you considered upgrading to Hotfrog AdVantage? No competitor advertising means exclusive focus on your business. You take centre stage.
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
Hotfrog Small Business Hub


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Erick Erickson" <erickerick...@gmail.com>
|Re: combined filesystem and web search
|Tue, 11 Jul 2006 13:48:27 GMT
I can answer a few of these. If you haven't yet, you'd do yourself a favor to pick up the book "Lucene in Action". It's written to the 1.4 code-base, the examples compile but give deprecated warnings for the 1.9 code base, and need a few more tweaks for the 2.0 code base. Also, download a copy of Luke. It's invaluable for looking at an index to answer questions like "why isn't this query returning what I thought it should?". That said, see below, and understand that I have exactly one 500K document (growing to 1M over the next few months) project under my belt with Lucene, so my opinions are those of an relative novice.... On 7/11/06, Tomi NA <email@example.com> wrote: > > I plan to make lucene (and nutch) a key element in an intranet > solution, but I only know about lucene what I've read in the last > couple of days. > Here's what I'd like opinions about. > > I would like to build a single point of access to data on intranet web > pages and LAN shared documents. > > I've looked into the file:// vs. http:// issue and it seems that it > doesn't make sense securitywise to use file:// so I'd make the shares > accessible through a web server and *then* index them. > However, if I leverage the web inbuilt lucene search, I'd build two > "indices" (please pardon the lack of knowledge of lucene terminology). > Can I search over two indices? Do I have to merge them? How would I do > the former or the latter? I'll let folks who understand security answer this one <G>. Is there a good explanation somewhere how to set up incremental > indexing, rather than e.g. building the whole index over nightly? See Luncen in Action (LIA). The short answer is yes. In the simplest form, you can just add new data to a currently-existing index. You probably want to make a copy just in case your power goes out or something. Then there's IndexMergeTool which I haven't used, but looks interesting. Then there's the possibility of using a MultiSearcher, but I'll leave it to the experts to talk about how that combines results.... Will lucene produce usable results, knowing that there'll be no rich > interlinking between a major part of the content (shared docs) to base > ranking upon? I know lucene uses a number of criteria to rank > documents upon: I'm asking about real-world experiences and subjective > grading quality impressions. > Does anyone have similar experiences with intranet enterprise data > searching? > > Cheers, > Tomi > > --------------------------------------------------------------------- > To unsubscribe, e-mail: email@example.com > For additional commands, e-mail: email@example.com > >
|View raw message