text:
From the Crap Archives: 1001 Ways to Be Romantic
Your Crap Archivist brings you the finest in forgotten and bewildering crap culled from basements, thrift stores, estate sales and flea markets. I do this for one reason: Knowledge is power.
1001 Ways To Be Romantic
Author: Gregory J.P Godek
Publisher: Casablanca Press
Date: 1995
Discovered at: Thrift store
The Cover Promises: If you own this, your relationship is failing.
Representative Quotes: "490. Greet him at the door with confetti." "495. Is he a Doctor Who fan? Sign him up to be a member of the Companions of Dr. Who. Write to PO Box 56764, New Orleans, Louisiana, 70156." "377. Wind-up toys! -- Monsters that walk and shoot sparks, creeping bugs, racing cars, crawling babies, lumbering robots, etc!"
The truth hits around entry 640 in this compendium of gimmicky bullshit that couldn't possibly make up for the years of relationship neglect that would inspire a person to buy it. That's when list-maker Gregory J.P Godek stops suggesting you visit the New England Carousel Museum (484) or pretend to be "a researcher working on a new edition of The Joy of Sex and you need her help with your studies" (419) and instead offers honest-to-God useful advice for couples hoping to recall whatever feelings got them into this in the first place:
"Listen for a change. You'll learn a lot about your partner."
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Yes, listening, that practical, bond-building technique that is to relationship advice books what eat-less-and-exercise is to diet manuals: the labor-intensive obvious answer the rest of the book gives you excuses to avoid.
Even Godek, who calls himself "America's Romance Coach" right there on the cover, doesn't have much to say about listening. Instead, in just a page or two, he's back to quick-fixes, recommending a bicycle built for two (648), or listening to A Prairie Home Companion (654) or purchasing Leo Buscaglia videotapes (651).
Other Godek suggestions:
57. "Want some suggestions for notes, gifts, and trinkets to hide? Again, from Romance Class participants: Friendship rings. Earrings. Condoms. Far Side comics. Hockey tickets. Love Coupons."
381. "The New Yorker is a great source for relationship-oriented cartoons!"
384: "Tape a comic to the bathroom mirror . . . or to the rear-view mirror in his car. Hide 20 comics all over the house. Insert them in dinner napkins. Stick them in cereal boxes. Attach them to the underside of the toilet seat. Fill his briefcase with them."
434. "Memorize her favorite poem, or the lyrics to her favorite song. Recite it at private times, or while making love."
633. "Have your handwriting analyzed!"
745. "Name your boat after her."
829. "Make a giant greeting card out of a big cardboard box."
889. "Write your own version of 'Your Song.'"
This last one is confusing. Wouldn't my own version of "Your Song" be "My Song"? You hope I don't mind/you hope I don't mind/That you put down in words/how wonderful life is while I'm in the world.
Shocking Detail: Our relationship Scheherazade is also fond of "Love Coupons." (He even got a whole other book out of 'em.) His suggestions:
I would only add one: "I'll Stop Taping Marmadukes to the toilet" coupons.
Highlight: On occasion, your Crap Archivist is asked, "What is the most sure-fire method to quickly determine whether or not a book qualifies as crap?" While I could point to many helpful rules-of-thumb, to date I have relied on only one clinical test of inviolable integrity:
Is the book in question by Tim LaHaye?
Today, I add a second:
Does the book in question contain a blurb from TV funnyman Jay Leno?
Sweater Fashions
Publisher: Coats & Clarks
Date: 1963
Discovered at: Estate sale
The Cover Promises: Nobody's invented sex yet.
Representative Quote: "The attractive diamond pattern is formed by popcorn stitches."
In 1962, heaven was, for white America, just countless hours of knitting away. Here's what had 'em looking sharp while Mississippi burned:
The Laura Bush flack jacket.
A hot new look for ventriloquists and their dummies!
Finally, what Big Man on Campus wouldn't feel dreamy in this shawl-collared jacket obviously inspired by sock monkeys?
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Fantastic tour. Guide Sisi was amazing for the Acropolis portion, both at the site and in the Museum. Normally I don't like guided tours of museums, but she pointed out stuff that I found fascinated that I would have missed otherwise. It's a remarkable museum.
We went on Christmas Eve, so no one was at the Acropolis and it was heaven. When we got to the Parthenon, there were less than 50 people up there. Glorious!
Cape Sounion was in the afternoon. Our driver was awesome and the ride was gorgeous. The key to the site is to be there at or near sunset for stunning photographs. Otherwise it's a meh excursion, you go down, you come back. Still worth doing if you are there are sunset.
Great tour with a very knowledgeable and fun tour guide!! Well worth it!!
Richard S USA
The walking tour was really amazing. The guide was super friendly and personable in addition to being knowledgeable about Athens, its' sights and its' history she even gave us recommendations on restaurants. The trip to Cape Sounion in the afternoon was equally great. It was about an hour drive outside of Athens so there was quite a bit of sitting on the bus. This entire tour was totally worth it especially for people who don't have a lot of time to spend in Athens because it certainly brings you to the highlights of the city.
Great tour. Pace was perfect. Guides were very knowledgeable. Definitely recommend.
Very good experience, especially on the walking tour. Our guide Katerina was very good and she made an effort to talk to everyone separately on the walk. She also gave many interesting facts about the Acropolis
Marina USA
The best guide!!! Loved everything about this walking tour!
Not happy with Acropolis part...only from a money standpoint. they wanted 20 Euros to go there. your brochure said 12 ...quite a difference. Overall the trip was excellent, including the guide.
This tour was very exciting, informative, and personal. We had an AMAZING time with our guide and truly learned a lot from our experience. I would recommend this tour and this guide to anyone who plans to travel to this area of Europe. The tour was well-worth the money, and I will definitely book this tour or a similar tour the next time I travel!
The walking is a good deal if you only have a day or two in Athens, Otherwise , you can do it all on your own with 3 day trip. We enjoyed the tour. Cape Sounion is ok . Nice drive along the sea. But really kind of a yawn after seeing the Acropolis.
It was a marvelous and magical experience. We went back on time on every step we climbed towards Cape Sounion and Temple of Poseidon.
I have told every friend I have to use Viator, we fell in love with all our tour guides because of their passion and knowledge.
This was a great experience and the sites were amazing. This is a must see and do.
Our guide was very informative and we had a wonderful tour.
Easy to find meeting place. Tour guides were very knowledgeable and friendly. Awesome trip - highly recommend. Be prepared to do a lot of walking
Great tour of the Acropolis. Guide was wonderful and very knowledgable. The trip out to Cape Sounion seemed to be run by a different group and they weren't as good. The ride was long and not a lot of information given. When you got out there I think we spent way more time there than we needed to but I understand you have to justify the trip out there so you can't just spend 30 minutes and leave. Also, it was about 94 degrees F and being out in the sun all day just got to us so that could be why the afternoon wasn't as good as the morning.
I have wanted to visit Delphi since 9th grade,1962 and it was worth the wait. Excellent tour guide and very nice bus.The walking tour of the Acropolis was wonderful if not hot. Super tour guide. The afternoon trip to the Temple of Poseidon was a welcome treat in the afternoon.Chat tours did fine wor
A must see when visiting Greece!
This tour was amazing!
Wow.... Beautiful!!!
Booking these together was well worth it. Tour guides were very smart and both trips were tours I will never forget!
Mercedes United States of ...
This is a must when you go to Athens. Make sure you wear tennis shoes and if in summer a hat. Bring water. The tour guide was fantastic and very knowledgeable. There is a lot of walking and plenty of ancient history to absorb.
The Acropolis walking tour was amazing. To be that close to history was phenomenal and our tour guide Pantelis did a wonderful job of educating us about so many of the aspects of that era. We also had some free time to really see the Acropolis and Parthenon.
We then walked back to our meeting place where we had a short lunch break.
After lunch we took a bus to Cape Sounion and the Temple of Poseidon. It was a beautiful drive along the coast and our new guide Effie did an excellent job of describing the sights along the way. She also gave us the history of the Temple of Poseidon.
There is a lot of walking on uneven ground for both of these tours, so if you can't navigate hills and rough terrain I would not recommend this tour. If you can, then it's a 'must do'.
A couple of expenses to note before you leave your ship or hotel:
Price of the cab ride to and from the meeting place.
Price of admission to the Acropolis
Price of lunch-the tour met at a hotel and they had a varied menu/excellent food
Really enjoyed this!
Fun to meet other tourists and also see the sights. Very happy I booked this tour
A must when in Athens. The tour gave my wife and myself a real sense of the importance of the Acropolis ruins. Our guide was very knowledgable and gave us a sense of why it came to be. The second part of our tour to the temple of Poseidon gave us an opportunity to see the Greek coastline. The the temple is spectacular. The commanding view was worth seeing by itself.
Our tour guide for the acropolis walking tour was outstanding and the tour felt very personalized to us. The guide was extremely knowledgeable and fun.
The tour to Cap Souion and the Temple of Poseidon was amazing. The drive was beautiful and we loved the ruins. There were only a handful of tourists there and it was nice to get to see this place without the throngs of people at places like the acropolis.
Great tour
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|Document Type:
|All Authors / Contributors:
Timothy K Kuhner
|9780804780667 0804780668 9780804791564 0804791562
|OCLC Number:
|xiii, 360 pages ; 24 cm
|The question raised by America's design --
Free market democracy --
Corporations speak --
Consumer sovereignty --
Why capitalism governs democracy --
Plutocracy --
Capitalism and democracy reconciled.
|Other Titles:
|Capitalism versus democracy
|Timothy K. Kuhner.
Examines the role money plays in politics, and the increasing influence of corporations in American democracy. Exposes how the Supreme Court has contributed to this situation, and argues that a constitutional amendment is needed to set boundaries between capitalism and democracy.
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"In Capitalism v. Democracy, Professor Timothy Kuhner convincingly shows that by blurring the line between economic and democratic values and rationalities, the legal regime governing money inRead more...
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- Capitalism.
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- Valkampanjer -- ekonomiska aspekter -- juridik och lagstiftning.
- Grundlagar.
- Politiska förhållanden.
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- Förenta staterna.


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Lot 155: Set Of 10 Magnolia Green Ice Cream Cups
October Estate & Collectible Catalog Auction
by Charleston Auction House
23 October 2016
Charleston, SC, USALive Auction
Past Lot
Looking for the realised and estimated price?
Description: 3.75x3.75
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Free standard shipping over GBP 60.00
The Swarovski crystal necklace collection is a varied and vibrant selection of exceptionally designed pieces adorned with the brand's renowned precision cut clear and coloured crystals.
From simple yet beautiful rhodium or gold-plated strands embellished with clear and coloured crystals to sophisticated statement pieces, the Swarovski necklace collection features a stylish selection of crystal jewellery pieces that showcase the brand's innovative and modern design.
The intricate coloured crystal beading of the collection's pieces, the fresh, summery layers of the crystal and pavé necklaces or the bold baroque feel of the more gothic selections are just a few of the exquisite examples of refined design that the Swarovski crystal necklace collection has to offer.
Whether displaying naïf motifs, a shimmering shower of beads or a stunningly placed crystal centrepiece, Swarovski necklaces can be perfectly matched with the singular selection of earrings and bracelets.
Gisele Necklace, Medium, Green GBP 99.00
Gisele Necklace, Green GBP 149.00
Gisele Necklace, Large, Green GBP 249.00
Glow Necklace, Small, White GBP 85.00
Glow Necklace, Large, White GBP 249.00
Glow Necklace, Small, Blue GBP 85.00
Gaia Necklace, Green GBP 199.00
Garance Choker, White GBP 85.00
Fortunately Necklace GBP 99.00
Moselle Strandage, palladium plating GBP 399.00
Moselle Neck Piece, palladium plating GBP 699.00
Grass Strandage, Blue GBP 159.00
Forever Birthstone Necklace, May, Green GBP 69.00
Grass Strandage, Pink GBP 159.00
Sparkling Dance Round Necklace, Blue GBP 85.00
Glance Necklace, Green GBP 99.00
Gallery Pear Layered Necklace, White GBP 79.00
Forever Birthstone Necklace, March, Aqua GBP 69.00
Generation Necklace, Teal GBP 199.00
Sparkling Dance Round Necklace, White GBP 85.00
Glance Necklace, Black GBP 99.00
Sparkling Dance Heart Necklace, White GBP 85.00
Dear Necklace, Medium, White GBP 85.00
Kalix Strandage, ruthenium plating GBP 479.00
Glance All-Around Necklace, Black GBP 199.00
Moselle Strandage, palladium plating GBP 399.00
Gray Necklace, White GBP 85.00
Gallery Square All-Around Necklace, White GBP 249.00
Great Star Necklace, Blue GBP 99.00
Glance Necklace, Blue GBP 99.00
The Beauty and the Beast Necklace GBP 249.00
Wood Crystallized Necklace, gold plating GBP 479.00
Garden Necklace, Small, White GBP 99.00
Iconic Swan Double Necklace, Black GBP 85.00
Garden Layered Necklace, Large, Green GBP 199.00


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I would rather die
than cry.
You tore my heart out but I'm still here,
you don' look at me the same, with love and passion,
instead, I see fear and hatred.
What did i do to make you hate me?
I gave you my world, my love, but it wasn't enough, was it?
I stand here asking you why, looking in your eyes,
but your not looking back.
Do I give up and walk away or fight?
You once told me you'd do anything for me,
is that still true?
I would rather feel a thousand knives then beg.
I needed you, you were my everything.
And now, I'm just a shell of my former self,
hollow and bare.
But you wouldn't know would you?
I'd rather you shoot me then tell you how I feel.
© Copyright 2017 windcharm. All rights reserved.
Status: Finished
Genre: Poetry
Awww..... this makes me feel sad. sniff. sniff. :( It makes me want to cry. Very good. You're just so good at poetry.
Book / Romance
Book / Romance
Book / Young Adult
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Disodium EDTA
Disodium EDTA appears as a white, odorless crystalline granule or a white to nearly white powder. Also known as Copper Disodium Ethylenediaminetetraacetate, the product is used as a sequestrant,and preservative in the food and beverage industry. It finds application in breads, dressings, cereals, nutritional bars, sauces, spreads, sweeteners, and prepared sausages.
- Specification Sheet (英语)
A & Z Food Additives Co. Ltd. specializes in researching, developing, and exporting quality ingredients and dietary supplements. Their additives include emulsifiers, sweeteners, preservatives, anti-caking agent, bulking agents, and many more. To remain competitive, the company is focused on developing novel ingredients and providing excellent service.


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: C2G 29310 Cat6 RJ45 UTP Keystone Jack
Pros: The punch down is easy, the cover fits nicely. Labeled for both A and B standards.
Cons: You need to bend the bracket, or shove some small object under it, to keep the jack in a standard keystone jack faceplate. I've tried it with cables to go and trendent faceplates, just doesn't want to stay in there as is.
Other Thoughts: Kind of annoying that it has to be messed with to make it stay put, but other than that it works.READ FULL REVIEW
This review is from: CORSAIR 2GB (2 x 1GB) 200-Pin DDR2 SO-DIMM DDR2 667 (PC2 5300) Dual Channel Kit Laptop Memory Model VS2GSDSKIT667D2
Pros: So far I've had no problems with any corsair memory, and these were no different.
Cons: NoneREAD FULL REVIEW
This review is from: TRIPP LITE SRSHELF2P1U 1U Cantilever Fixed Shelf (40 lb / 18 kg capacity; 12-in. / 305 mm depth.)
Pros: I was looking for a shelf to place at the bottom of a wall mounted equipment rack, that was 12" deep. It fits perfectly. More than adequate to hold the poe injectors and other loose items hooked into my rack.
Cons: Seams a bit pricey for a metal tray with holes in it.
Other Thoughts: Nothing else I found would fit like this one did. If you need a shelf for a 12" deep equipment rack, than this is perfect.READ FULL REVIEW


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Superior vocal presentation that include Gospel, Soul, Motown, and R&B cover tunes and also great presentation with country and beach tunes.I have performed at countless weddings, church concerts, receptions, banqets, corporate functions, and many more events. Audiences and guests will be overly delighted. Whatever your songs or needs are I will give you 110% satisfaction. Contact today for a...
Copyright © 2001-2017 OneWed Inc.
All Rights Reserved.
Copyright © 2001-2017 OneWed Inc. All Rights Reserved.


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Buick for Sale
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1975 Buick LeSabre Convertible
Indian Wells, CA
1975 Buick LeSabre convertible, 88700 original miles,white exterior, new interior has palomino brown dash, carpeting and panels with white Vinly seating. Air conditioning, Sirius satellite radio with... More
1967 Buick
Lutz, FL
Power, rarity, and beauty this 1967 Buick GS 400 convertible offers you all that you love in an American classic, and it's available... More
1955 Buick Super Series 52
Naperville, IL
This is a beautiful car. It is a big head turner. Runs and drives out well. Just spent over $1600 in maintenance recently. It... More
1937 Buick 60 Series Custom
Sandy, UT
1937 BUICK SERIES 60 CUSTOM 4 DOOR SEDAN This is a rare slant back car with lots of body modifications. It comes with a... More
1970 Buick Wildcat
Lillington, NC
Stk#041 1970 Buick Wildcat Painted Harvest Gold BC/CC paint that is beautiful this auto is an eye catcher. Tan vinyl top that looks new, driver's... More
1970 Buick 10
Greensboro, NC
... More
1969 Buick Riviera
Greenville, NC
Beautiful restoration of a classic marque with PS, PB, PW, AT, P. Seats, Cruise Control, Tilt Steering Wheel, AM-FM Radio, Vinyl Top. Original factory... More
1968 Buick Gran Sport Convertible
Indianapolis, IN
Restoration in 2012- Less than 2,000 miles since restoration- Power steering- Power brakes- Bench seats- Hurst shifter- American Muscle gaugesTo be sold at the... More
1965 Buick Riviera
Indianapolis, IN
401 CI engine- Automatic transmission- Power steering- Power brakes- Tilt wheelTo be sold at the Indy 2017 auction, Indianapolis, IN, May 16-21, 2017. To... More
1961 Buick Special
La Jolla, CA
1961 Buick Special1961 Buick Special model in a 'RestoMod' conditionClassified as a 2-Door Sedan with several Options includedEquipped with a 215 (.030 over)ci Aluminum... More
Advertiser since 2010
1922 Buick 4 door
Burnsville, NC
1922 Buick 4-door, Good running condition with 4 new tires. Beautifully renovated interior. Solid body, needs minor dings restoration and paint work to complete. Comes... More
1960 Buick Electra 225
Denver, CO
Worldwide Vintage Autos is pleased to present this 1960 Buick Electra 225 Convertible. Hagerty Values a number car 2 at $78,700 and a number car... More
Advertiser since 2012
1965 Buick Riviera Coupe
Santa Monica, CA
West Coast Classics are proud to present a very striking example of this southern California and completely rust free 1965 Buick Riviera V8 coupe... More
1950 Buick Special
Milpitas, CA
Call or visit our website for more information!... More
1970 Buick Gran Sport 350
Stratford, NJ
1970 BUICK GRAN SPORT 350, This Buick is the REAL DEAL --MATCHING NUMBERS Gran Sport.... 350 cu. in. ---315 HP,automatic,Power steering,Power brakes and AIR... More
1977 Buick Regal Regal
Stratford, NJ
A collector car that is a VERY reasonable buy-in to the hobby !! NICE gold paint and the CHROME CRAGAR SS wheels make it... More
1992 Buick Riviera Deluxe
Stratford, NJ
This is a Future Collectible and now is the time to get it when the prices are so low. Original White Pearl Paint with... More
1984 Buick Riviera Custom Wheels
Stratford, NJ
Just arrived from and Estate total restoration looks and runs great 350 Motor..... Flowmaster mufflers........ sounds great!!!!! New Paint and new Bumpers......looks like new!!!... More
1971 Buick Skylark Gs
Stratford, NJ
Just arrived 1971 Buick Skylark 2 Dr Hardtop GS hood and much more.............. More
1970 Buick Electra 225 Convertible
Stratford, NJ
Check out this rare beauty!!!! 1970 Buick Electra 225 Convertible outstanding in and out mostly original low miles just 57,758 miles on it since... More
1968 Buick Electra 225 Limited
Stratford, NJ
Just arrived from a Private Collection.....1968 Buick Electra 225 Limited four door Hardtop THIS CAR IS BREATH TAKING LOOKS AND RUNS LIKE IT LOOKS... More
1972 Buick Centurion
Stratford, NJ
1972 BUICK CENTURION.... LOOK!!! at this low mileage Classic With Factory A C. that works....this is a Classic that you should enjoy for years..........A... More
1976 Buick Electra 225 Custom
Stratford, NJ
1976 BUICK ELECTRA 225 CUSTOM, Yes this was dad's old car that just came in to be sold. BOY I LOVE those 225 ht... More
1987 Buick Grand National
Lakeland, FL
1987 Buick Grand National.Climate controlled storage, true museum quality. Very desirable non T-Top 87. Books and paperwork, perfect history. ... More
1984 Buick Riviera Convertible
Commack, NY
Nice riding / clean car - all mechanical and electical systems in good working order. Tires replaced Fall 2016 Owned for 3 1/2 years - -just... More
1987 Buick Grand National 2 Door
Mundelein, IL
1987 Buick Grand National Powered by a 3.8 L Turbo V6 Engine SS Headers and Exhaust Larger turbo and Bigger Fuel Injectors Turbo Cam Automatic Trans ( from a... More
Advertiser since 2013
1939 Buick Special
Sherman, TX
Classic Car Liquidators is the leader in affordable muscle cars. Please give us a call for more information on this vehicle. Also visit our... More
1964 Buick Riviera Coupe
Emmerich, Germany
1964 Buick Riviera 2D Hardtop CoupeThis beautiful Buick is a very popular vehicle from the muscle car era.Under the hood we find the gigantic... More
1967 Buick Skylark Convertible
Alsip, IL
"Get In With The In Crowd In A Skylark! . A Sweeter-Handling Machine, A More Comfortable Chariot You'll Never Find." 1967 Skylarks Got All The... More
1954 Buick Skylark Convertible
Milford, OH
The 1954 Buick Skylark was designed by Harley Earl of GM fame as a sports car for the rich and famous. A rare car,... More


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Would this be a good cold day activity?
Is this an outdoor attraction or activity?
Does this activity require advanced planning, ticketing or reservations?
Is this attraction a hidden gem or off-the-beaten path?
Is this activity accessible without advanced planning or reservations?
Is this attraction a "must-see" location?
Is this attraction suitable for all ages?
Is this attraction pet friendly?
Would this be a good hot day activity?
Is this attraction exciting, unusual, or risky to visit?
Thanks for helping!
A great place to visit. We visited recently for the Lego display and also back in December for the Holiday display. Both were excellent. Looking forward to spring when the whole...
read more
A great place to visit. We visited recently for the Lego display and also back in December for the Holiday display. Both were excellent. Looking forward to spring when the whole garden is open.
I really don't have anything much to add except to reiterate that this place is probably worth a visit any time of the year. We will probably, now having visited in the "off" season, make a return trip to Omaha just to see the gardens in full bloom in peak season(s) - loved it!
Visiting the Lauritzen Gardens is always a special treat! The addition of the botanical gardens makes the trip to the Gardens a wonderful, year round experience. It is amazing to see all of the plants growing. Seeing the poinsettia tree and train exhibit in December is a special tradition.
We went for the botanical gardens and were immediately stunned by the LEGO displays. There are places for the kids to take a break and build their own. LOTS of hand sanitizer available. Bananas growing in February. BEAUTIFUL selection in gift shop. Paved paths, elevators, nicely designed.
This is very impressive. The indoor botanical garden is huge. Easy to get to if you are downtown or near the zoo.
Very cool place to spend some peaceful time and some scenic and aromatic surroundings. So close to the Omaha zoo can make a nice weekend.
This garden is so diverse. There is always sometime going on in the entrance center. The trails are lovely and the large scale model railroad is great for kids. There are also the large engine to explore.
We attended a class held for 3 year olds and it was very good. It started with a "R" project involving cutting, coloring and pasting. We listened to a story, sang, then went on a walk to see the Lego exhibit. Due to the snow, we were not able to walk outside. But, the class instructors were engaging and fun...
The poinsettias were beautiful...all varieties. Learned the gardens takes in 5,000 small plants...grows them and then displays all these plants at Christmas...making up the beautiful tree and other decorative highlights. Enjoyed going thru the conservatory and seeing Christmas/festive decorations there also. Trips to the gardens are always different, interesting, memorable, and I leave looking forward to my next visit!
I love all the extras that Lauitzen Gardens has in addition to the beautiful variety of plants, flowers and trees. The summer concerts, the quilt show, the orchid show, the Lego exhibits and those of other artists. Lauitzen Gardens does great job of activities for all ages and interests. So pleased to have this fabulous facility in Omaha.
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How long should I plan to spend at the Gardens? Wondering how long it will take to see. FYI, I'll be there in March.
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We are pleased to provide this website as an introduction to our charming Episcopal Parish Church and Retreat House in Inverness, California. This website offers information about our sanctuary, overnight lodging, events, meeting facilities and workshop accommodation.
We are located in West Marin (County) in a forest setting along-side and overlooking Tomales Bay at the entrance to the natural splendor of the Pt. Reyes National Seashore. Driving time is about 60 minutes north of San Francisco. In addition to the peace and serenity of our historic facility, close proximity to wonderful recreation offers the opportunity for long isolated beach walks, marvelous varied trail hiking, kayaking, and birdwatching.
Use the Links below (or the navigation offered at the top of this page) to discover the diverse opportunities for Respite, Rest, Renewal available for Individuals, Groups, Special Events, Family and Community gatherings for weekday and weekend overnight stays and day use.
EXPLORE – Pictures!
Our Photograph collections are a visual introduction to our "Special Place" in God's universe. It includes pictures of our Special Setting, our Sanctuary, Chapel, and our Retreat House Sleeping Accommodations, Kitchen and Meeting Spaces.
- We hope that these images invite you to explore our website and will entice you to visit us in person!
Easily find information about our Parish, Worship Services, and Events including St. Columba's 2017 Contemplative Easter Weekend retreat.
There is also some information about our Episcopal tradition for those who are curious about our denomination. All worship traditions and denominations are welcome!
Get information about overnight lodging, day-use, meeting facilities and event provisions, including pricing. A quick link is provided to the photograph collections in order to help your assess the meeting rooms and sleeping accommodations for personal, family and group retreats.
CONTACT and DIRECTIONS
Whether by phone or email or through the form provided, we invite your contact. Driving Directions and a Mapquest link are included.
We ask that you keep the St. Columba's Church and Retreat House worship and hospitality in your prayers. Including us on your social media helps us grow our "good news".
Further support whether monetary or the gift of time and labor is always appreciated and can be done through our Contact page. We are a 501c non-profit organization; all gifts are fully tax deductible.


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Judging Journalism: The Turn Toward Privacy and Judicial Regulation of the Press
Amy Gajda
Tulane University - Law School
September 22, 2008
Illinois Public Law Research Paper No. 07-20
California Law Review, 2009
Courts, John Marshall famously declared, must "say what the law is." Increasingly, it seems, they are also called upon to say what the news is. When subjects of unwanted publicity sue for invasion of privacy or other torts, journalists commonly defend on the ground that the challenged disclosures were privileged as newsworthy. Traditionally, courts minimized constitutional concerns by deferring heavily to journalists' own sense of what qualified as news; that a story made the newspapers or the evening news was itself nearly conclusive evidence that the topic was of legitimate public interest and therefore beyond the control of tort law. Recently, however, courts have grown decidedly less tolerant. Driven by mounting anxiety over the loss of personal privacy generally and by declining respect for the press specifically, courts are increasingly willing to impose their own judgments about the proper boundaries of news coverage. Ironically, an emerging tool used by courts to police news outlets is journalists' own codes of professional ethics. By measuring editorial decisions against gauzy internal ethics standards, courts give the appearance of deference to the profession while, in fact, aggressively scrutinizing editorial judgments.
This Article demonstrates the growing threat to press freedom posed by these emerging trends. Part I places the conflict in historical context, showing how evolving legal understandings of privacy and press freedom set the two on course for a modern collision over "newsworthiness," which was resolved initially by deferring to journalists' editorial judgment. Part II explains how recent developments - including growing resort to journalists' codes of professional ethics - have undermined judicial deference to journalism in defining the news. Part III examines the implications of the nascent resurgence of tort regulation of journalism, and Part IV concludes by suggesting ways in which courts and journalists individually might end this narrowing of news.
Number of Pages in PDF File: 86
Date posted: March 10, 2008 ; Last revised: October 28, 2008
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Petco Granger
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"Modern Family's" hottie Sofia Vergara talks to Esquire about her accent getting worse, not better, and bad celebrity plastic surgery.
And she singled out Madonna as one of the worst examples of the heinous over-filled face trend.
"L. A. is crazy," says Sofia. "The women all look the same now. That thing with the
cheeks. Like Madonna. Who do they think they're fooling? It doesn't
make them look young. You end up looking like a freak."
]]>The advances in facial fillers may have stopped the old fashioned face lift over-pulled look. But it's also created a tribe of chipmunk-cheeked women. Just ask Lisa Rinna, who has admitted in her book "Rinnavation" to OD-ing on filler. Follow Zap2it and Elizadish on Twitter and Zap2it on Facebook for the latest TV, movie and celebrity news
Photo credits: Getty Images


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Custom Stationery from luxury designers!NEW! Wedding Invitations Customize any Address Stamp to match your style!
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text: In my article "Instagram Sees Posts Slowing," I discussed why Instagram was losing out to Snapchat (Private:CHAT). To summarize, Snapchat is the equivalent of a doodle pad, while Instagram (NASDAQ:FB) is like a resume. You add to a doodle pad without thinking, while you don't change your resume unless something important happened in your career. …Read more »


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Public invited to event featuring former Saints
By PRESTON GILL
PATTERSON — Former New Orleans Saints players will "meet old friends and tell old lies that get bigger and bigger each year about how they used to do it back in the day" at the sixth annual celebrity golf tournament Friday according to former Saint, LSU and Patterson High running back Dalton Hilliard. The scramble golf tournament will be held at the Atchafalaya Golf Course at Idlewild in Patterson.
The public is invited to attend the event without charge to meet and get autographs as gridiron stars from the past reminisce and network with marine and oilfield-related businessmen in the tournament. Hilliard and Patterson Police Chief Patrick LaSalle have hosted the event each year.
Hilliard rattled off the names of former NFL players he expects to be a part of the event. Among them were Heisman Trophy winner George Rogers, former LSU Tiger Hokie Gajan, 2010 NFL Hall of Fame inductee Ricky Jackson, John Fourcade, Stan Brock and other former Saints, as well as players from other NFL teams.
"This isn't a tournament about competition," explained Hilliard. "A lot of former players are successful businessmen. This is an opportunity for them to renew old ties while networking with each other and with other businesses. It is also an opportunity for the public to come out and talk with them and enjoy some good food at the same time."
For instance Hilliard owns Southland Energy Services, a contract labor company in Houma that supplies welders, fitters and electricians for fabricators and shipyards throughout the Gulf region. He sees the yearly golf tournament as an opportunity to mix pleasure and business.
"This is an opportunity for us to have a good time with customers and future clients throughout the oilfield, fabrication and shipyard business," said Hilliard.
Tee-off time for the event is scheduled for 7:45 a.m. and it is expected to wrap up in the late afternoon or early evening.
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text: British firm 2UP Gaming PLC is looking to purchase a casino in Atlantic City, N.J., now that the state has legalized online poker. The firm may decide to build a casino in Atlantic City if it can't find a suitable property to acquire. "They could build a standard casino or look at one of the two boutique licenses out there right now," said Matthew Levinson, chairman of New Jersey Casino Control Commission. "There's a lot of opportunity now in the city."


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text:
Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity
- Stefan Carlsen1,
- Kutty Selva Nandakumar1 and
- Rikard Holmdahl1Email author
DOI: 10.1186/ar1989
© Carlsen et al.; licensee BioMed Central Ltd. 2006
Received: 30 March 2006
Accepted: 6 June 2006
Published: 3 July 2006
Joint cartilage is attacked in both autoimmune inflammatory and osteoarthritic processes. Type IX collagen (CIX) is a protein of importance for cartilage integrity and stability. In this study we have backcrossed a transgenic disruption of the col9a1 gene, which leads to an absence of CIX, into two different inbred mouse strains, DBA/1 and B10.Q. None of the CIX-deficient mice developed observable clinical or microscopic osteoarthritis, but DBA/1 male mice had more pronounced enthesopathic arthritis, the so-called stress-induced arthritis. Both DBA/1 and B10.Q strains are susceptible to the induction of collagen-induced arthritis, and CIX deficiency in both strains led to the development of a more severe arthritis than in the controls. Induction of arthritis with monoclonal antibodies against type II collagen (CII) led to an earlier arthritis in the paws that also involved the knee joints. The antibodies used, which were specific for the J1 and the C1I epitopes of CII, initiate their arthritogenic attack by binding to cartilage. The C1I-specific antibodies bound to cartilage better in CIX-deficient mice than in wild-type animals, demonstrating that the lack of CIX in cartilage leads to an increased accessibility of structures for antibody binding and thus making the joints more vulnerable to inflammatory attack. These findings accentuate the importance of cartilage stability; cartilage disrupted as a result of genetic disorders could be more accessible and vulnerable to an autoimmune attack by pathogenic antibodies.
Osteoarthritis (OA) and rheumatoid arthritis (RA) are both degenerative diseases of the joint and affect articular cartilage, synovium and bone with a loss of function and joint deformity. RA is, however, an inflammatory disease that involves a joint-specific autoimmune attack. Collagen type IX (CIX) is a protein associated with hyaline cartilage, together with collagen type II (CII) and XI (CXI). The triple helix of CIX is composed of three genetically distinct polypeptide-chains and belongs to the group of fibril-associated collagens with interrupted triple helices (FACIT). CIX molecules cover the surface of the heterotypic fibril of CII/CXI in a periodic fashion. Covalent cross-links between CII and CIX as well between other CIX molecules are formed [1–3], suggesting that CIX might form a macromolecular bridge between fibrils and with other matrix constituents, compromising the stiffness and tensile strength of cartilage [4]. Evidence for such a role comes from studies of transgenic mice with a truncated form [5] or complete deletion of the α1(IX) chain, leading to an absence of CIX in the cartilage [6]. Both types of mice have been reported to develop a mild form of OA in the knees. In addition, the importance of CIX was highlighted when a form of multiple epiphyseal dysplasia, EDM2, was linked to the col9a2 gene [7, 8]. These patients developed irregular epiphyses with a gradual appearance of OA in the knees. Taken together, these observations suggest that CIX is important in maintaining the long-term stability of the articular cartilage.
The most widely used animal model for arthritis is collagen-induced arthritis (CIA), which has a disease course similar to that of RA, both in the spread of affected joints and in histopathological findings. CIA has a strong B-cell response, producing antibodies directed toward CII-specific structures [9, 10], and these antibodies have been shown to be pathogenic in passive transfer experiments [11–15]. CII-specific T cells promoted the arthritis initiated by these antibodies [16–18]. A requirement for T cells in CIA was demonstrated by using anti-CD4 [19] or anti-TCRαβ [20] monoclonal antibodies and T-cell-deficient mice [21]. However, T cells alone cannot explain the pathology in CIA; hence both humoral immunity and cellular immunity were found to be absolutely essential [17]. Similarly, it is also possible to study arthritogenic pathways by using animal models other than CIA to pinpoint the effect of different disorders and thereby fine-tune the understanding of the underlying mechanisms of RA. Such models are collagen-antibody-induced arthritis (CAIA) and stress-induced arthritis (SIA).
In CAIA it is possible to study the inflammatory phase of the immune response without involving the primary phase by activating a cascade of reactions involving complement [22] and Fcγ receptors [23]. Neutrophils and macrophages are the major mediators of this inflammation [12]. CAIA is also capable of initiating arthritis independently of T and B cells, actually in the absence of either T or B cells, but not both enhanced the disease, arguing for a regulative role for these cells [16].
SIA is a spontaneous arthritis occurring in old male DBA/1 mice that are grouped from different litters. Macroscopically, it is similar to CIA, with edema and deformity of the hindpaws; however, SIA is primarily an enthesopathy characterized by the proliferation of fibroblasts and the formation of periarticular enthesophytes of cartilage and bone that can result in marginal ankylosis. In contrast to CIA, SIA is T-cell independent and shows minimal proliferative synovitis, without involving large cellular infiltrates [24].
Ankylosing enthesitis is a pathological feature in a group of chronic arthritides known as spondylarthropathies, with the same inflammatory mediators as in RA. IFN-γ (secreted probably by the innate immune system involving IFN-γ producing cells such as natural killer and myeloid cells) was shown to promote SIA [25]. It has been well documented that bone morphogenetic protein (BMP), a member of the transforming growth factor (TGF) superfamily, is involved in endochondral bone formation. Recently, an antagonist to BMP was shown to inhibit the onset and progression of SIA [26]; however, TGF-β1 injected directly into the knees induced enthesopathies [27]. The causative factor of spondylarthropathies is believed to be an endocrine disorder in humans [28] and might also be a compensatory mechanism of joint instability, supported by the stabilization process of osteoarthritic knees [29].
This study was designed to address whether the development of autoimmune arthritis as in RA might be dependent on cartilage quality. To address this question we used CIX mutant mice lacking the α1 (IX) chain [6] and assumed that this mouse might be more susceptible to inflammatory arthritis because of mild cartilage matrix destabilization. The data presented here confirmed our hypothesis that these mice developed a more severe arthritis in CIA and CAIA, which could be explained by an enhanced accessibility of CII-specific antibodies to cartilage. We also found that this mouse was more prone to developing enthesopathy but we could not reproduce earlier findings that the CIX deficiency leads to OA.
Materials and methods
All mice were kept in a climate-controlled environment with 12 hours light/12 hours dark cycles, housed in polystyrene cages containing wood shavings, standard rodent chow and water ad libitum in the Animal Department of Medical Inflammation Research in Lund, Sweden. All experiments were performed on age-matched mice, between 8 and 16 weeks of age. The Lund-Malmö laboratory animal ethical committee approved the animal experiments described in this article.
Genomic DNA was prepared from the tip of tail or toe [30]. Transgenic mice were screened by PCR with primer pairs specific for the NeoR gene within the construct. Wild-type animals were determined by using another primer pair inside the Col9a1 gene that flanked the construct, yielding an incomplete product without amplification if the construct was present. Both primer pairs were run simultaneously for each sample during PCR, to yield on agarose gel electrophoresis two different products from each pair, depending on the haplotype.
Induction and evaluation of arthritis
Mice were immunized intradermally at the base of the tail with 50 or 100 μg of CII, prepared from Swarm rat chondrosarcoma. All dosages were emulsified with complete Freund's adjuvant (Difco, Detroit, IL, USA) in a total volume of 100 μl. In early experiments, arthritis was followed by using the original, referred to as the simple, macroscopic score system for the four paws ranging from 1 to 3: 1 = swelling or redness in one joint or toe; 2 = more than one joint/toe or the ankle affected; 3 = severe arthritis in the entire paw. During later experiments the scoring protocol was improved and animals were scored by the system ranging from 0 to 15 per paw [31], referred to as the extended protocol. For comparison, scores used with the extended system have been converted from original documents for each individual and day in accordance with the following relation between extended and simple: 1 = 1, 2 to 10 = 2, and 11 to 15 = 3.
Spontaneous development of arthritis is influenced by hormonal and behavioral factors [32]. It has been stressed that the number of mice is critical (at least three), and grouping should be from sexually mature mice from different litters for the induction of SIA. Selection was used randomly to reduce cage variations. Arthritis was assessed as described above.
To induce arthritis with anti-CII antibodies, GammaBind™ Plus Sepharose™ column (Amersham Biosciences, Uppsala, Sweden) purified IgG from the culture supernatants of B-cell hybridomas CIIC1 (C1I epitope) and M2139 (J1 epitope) [33–35] were solubilized in PBS, sterile filtered and injected intravenously [12]. Each antibody (4.5 mg) was given as a cocktail on two occasions in a total volume of 400 μl. On day 5, 50 μg of lipopolysaccharide per mouse was injected intraperitoneally into all mice. Arthritis was assessed as described above.
ELISA was performed with sera obtained at day 35 from mice through retro-orbital plexus bleeding. Microtiter plates (Immunolon 2 HB; Thermo Labsystems, Franklin, MA, USA) were used, otherwise the protocol was followed as described elsewhere [36].
CIIC1 (C1I epitope, ARGLT), M2139 (J1 epitope, MPGERGAAGIAGPK), CIIC2 (D3 epitope, ARGAQGPPGATGFP), CIIF4 (F4 epitope, ERGLKGHRGFT) and CIIE8 (E8 epitope, LAGQRGIV) antibodies were biotinylated as described previously [33]; 100 μg of antibodies in 100 μl of PBS was then injected intraperitoneally into 1-day-old mice [37]. The mice were decapitated a day later and the hindlimbs were immediately embedded in OCT compound (Sakura Finetek, Zoeterwoude, The Netherlands), snap-frozen in isopentane and kept frozen at -70°C until cryosectioning. Staining was performed as described previously [38].
Calculation of antibody binding
Sections were selected from the ankle region with homogenous, whole, round parts and from the same joint part as possible. All pictures were taken on the same occasion and stored as high-grade TIFF files, with SPOT advanced WIN v. 4.1 software (Digital Instruments Inc., Sterling Heights, MI, USA). All image analyses were performed at the same time with Easy Image Analysis 2000 v. 220.127.116.11 (Tekno Optik AB, Huddinge, Sweden) with threshold levels set as specifically as feasible and used unchanged throughout the analysis. The total area was marked manually and the software marked the stained area. The software calculated the stained area as a percentage of the total.
All ELISA data were first log-transformed and then used for calculations of the mean and an independent-samples t test, except for SD. Mean ELISA values are expressed as the antilog of transformed mean data (geo-mean). The Mann-Whitney U ranking test was used for score and one-way analysis of variance for onset. Pearson χ2 with Yates's correction was calculated for incidence, or Fisher's exact test if groups were of less than five. In antibody-binding studies an independent-samples t test was used.
Increased susceptibility to stress-induced arthritis but not osteoarthritis in CIX-deficient mice
To evaluate the susceptibility to arthritis in genetically pure inbred strains, the C9T mice were backcrossed into B10.Q and DBA/1 genetic backgrounds. These mouse strains express the MHC Aq class II gene, permitting susceptibility to CIA. In addition, DBA/1 males develop a spontaneous enthesopathy, denoted SIA, which readily develops after males are grouped together from different litters. The C9T mice were derived from a 129/sv line and were backcrossed for more than 10 generations followed by intercrossing and selection for minimal linked fragments, leaving a defined fragment around the col9a1 gene (Figure 1). C9T-BQ had a minimal 129-derived congenic fragment, whereas C9T-DQ had a larger congenic fragment that also contained DNA derived from both C57BL and 129 lines. The C57BL positive marker within C9T-DQ most probably originated from C57BL/6, which was used during transmission to a germline and then backcrossed with 129/sv to an inbred line [6]. Another embryonic stem 129 cell line, D3 [39], was used for electroporation but could not be distinguished from 129/sv by the microsatellite markers used. These strains seemed to have normal knee joints, because we did not find any microscopic or macroscopic sign of OA or other pathology in a large number of normal young and old (more than one year) mice of either strain. Samples were also taken from CIA and SIA experiments with littermate controls of both heterozygous and wild-type haplotypes, with additional inbred DBA/1 and B10.Q strains for negative comparison (data not shown).
Summary of experiments conducted on C9T mice
Simple maximal
Extended maximal
Anti-CII antibody
Day of onset
arthritic score
arthritic score
titer (μg/ml)
60.6 ± 39.1
8.6 ± 2.7e
371.7 ± 359.3
50.9 ± 8.2
5.4 ± 2.0e
532.1 ± 529.2
Wild type
55.6 ± 19.0
5.1 ± 2.9e
454.3 ± 489.0
62.8 ± 13.6
8.3 ± 2.0
29.9 ± 15.3e
Wild type
66.4 ± 17.3
6.0 ± 2.3
23.8 ± 8.2e
44.3 ± 18.4
3.1 ± 1.2f
43.7 ± 30.1
2.7 ± 1.6f
Wild type
39.2 ± 23.8
2.0 ± 0.9f
Homozygous Ab
5.5 ± 3.0g
4.8 ± 2.8
12.8 ± 11.2
Homozygous PBS
Wild-type Ab
8.4 ± 0.5g
5.6 ± 3.0
11.2 ± 8.5
Severity of collagen-induced arthritis is increased in CIX-deficient mice
Anti-type II collagen antibody staining on neonatal cartilage
Area fractiona
17.2 ± 9.8b
6.5 ± 1.8b
CIX-deficient B10.Q mice developed a more severe collagen-antibody-induced arthritis
Anti-CII antibodies bind more efficiently to cartilage lacking CIX
CIX-deficient mice have a subtle defect of the cartilage, which is here indicated by their higher susceptibility to developing spontaneous enthesopathic arthritis. Interestingly, these mice also developed a more severe autoimmune arthritis, as shown with the CIA model. Parts of this effect could be explained by the higher accessibility of CIX-deficient cartilage for binding of arthritogenic CII-specific antibodies.
CIX-deficient mice [6] have previously been shown to develop microscopic OA at one year of age, with loss of cartilage at the femoral and tibial joint surfaces and increased cartilage and bone formation at the periphery, leading to prominent shape changes. In transgenic mice with truncated CIX [5], OA was observed in mice up to one year old as a decreased intensity of Safranin O staining and roughening or erosion of the articular surface. In our study we could not detect either gait problems or histological OA. One reason for this might have been that we focused on mice with the CIX deficiency backcrossed to DBA/1 and B10.Q genetic backgrounds, which are not known to be sensitive for spontaneous OA, unlike the C57BL/6 and BALB/c [40] genetic backgrounds used in the previous studies. The development of spontaneous enthesopathy in DBA/1 mice is an indication of the presence of a good compensatory mechanism to preserve joint homeostasis [29], resulting in an improved repair mechanism for local injury [41]. However, enthesopathy in DBA/1 mice is a pathological event, with increased new bone formation in tissues where tendons and ligament attach, with abundant proliferative fibroblasts and chondrocytes. In our SIA experiments the homozygous mice developed a more severe disease, which suggests that the mediators released during stress affect chondrocytes profoundly, and chondrocytes might possibly try to compensate for the CIX deficiency by the overexpression of cartilage components.
To test our hypothesis about whether cartilage disorder could alter the course of arthritis as a result of enhanced accessibility to the immune system, we used our CIX-deficient mice in two different genetic backgrounds in CIA. In both these backgrounds a more severe development of arthritis was observed with CIX deficiency. This phenomenon could not be explained by increased turnover of the fragile matrix and, in turn, priming of autoreactive T cells or efficient tolerance induction, because the disease course was as self-limiting as in the controls. Similarly, there was no change in antibody titers, which argues against de novo priming of T cells. Still, there might have been a difference in the accessibility of cartilage to antibodies, because antibodies are shown to bind complement and to be involved in direct cell interactions via Fc receptors, which would certainly have an effect on disease progression. In fact, this was the case when tested with direct CII antibody injection: homozygous mutant mice developed arthritis much earlier than the controls and had more antibodies attached to the cartilage. This also ruled out the possibility of T-cells as the main promoter during the course of arthritic disease in this model, because antibody-mediated arthritis is T-cell independent.
Because CAIA experiments gave such a rapid response and also an apparent knee inflammation in both the mouse strains, we were prompted to perform in vivo binding studies with different monoclonal antibodies. Of the different antibodies used, CIIC1 binding to the C1I epitope showed an increased binding to cartilage. The C1 epitope was identified as a major epitope in generating the antibody response to CII, and the various antibodies thus developed recognized different parts of the epitope: the C1I epitope 359 to 363, the C1II epitope 359 to 366 and the C1III epitope 359 to 369 [35]. However, all antibodies are dependent on the first part of the epitope, where the CIIC1 antibody binds. The antibody response to the C1 epitope dominates the immune response in CIA in both mice [42] and rats [43].
The CIIC1 antibodies also impaired cartilage formation by cultured chondrocytes [44], strongly inhibited the self-assembly of CII in vitro [45] and caused disorganization of CII fibrils in the extracellular matrix without affecting chondrocyte morphology, along with increased matrix synthesis [46], and thus the antibodies directed to this epitope can contribute directly to cartilage destruction. Increased binding of CIIC1 to the CIX-deficient cartilage indicates that the C1I epitope is more exposed for the CIIC1 antibody in the absence of CIX and more antibodies bind per CII molecule in the deeper layers of cartilage.
Interestingly, antibodies against the C1 epitope have also been shown to be associated with RA [47]. Clearly, the C1 epitope is not only important for its immunodominance but also contributes to matrix component interactions, signaling and stability. In contrast, murine antibodies reacting to the F4 epitope were not arthritogenic in CAIA and were associated with OA rather then RA [47]. Furthermore EDM1, another subgroup of multiple epiphyseal dysplasia, and pseudochondroplasia are linked to defects in cartilage oligomeric matrix protein (COMP) [48] and share pathogenesis with EDM2 [49], suggesting that COMP and CIX are interacting in the large polymeric network of cartilage. Deficiency of CIX might therefore also lead to instability and changed exposure of COMP. Increased serum levels of COMP have not been detected in different human OA, but it would be interesting to study COMP-mediated pathology in CIX-deficient mice.
Using CIX-deficient mice of two well-defined mouse inbred lines B10.Q and DBA/1, which are susceptible to CIA, we have tested the possibility that disordered cartilage alters susceptibility to autoimmune arthritis. We found that the lack of CIX increased the binding of antibodies to the major epitopes on CII in cartilage and led to a higher susceptibility to both CIA and CAIA. RA probably represents a wide variety of diseases with different initiation events. It could in fact include subgroups that have a mild cartilage defect genetically. Such groups could be dormant but the presence of fragile cartilage could expose B-cell epitopes to binding of autoreactive antibodies. The bound antibodies could then initiates an inflammation with the release of cartilage antigens, thereby further driving an autoimmune attack towards cartilage proteins. This study supports the idea that a mild disruption to cartilage increases the severity of arthritis.
To understand the importance of CIX for cartilage integrity and stability and in the disease process of arthritis, we used a transgenic disruption of the col9a1 gene, leading to an absence of CIX, in two different genetic backgrounds (DBA/1 and B10.Q). None of the CIX-deficient mice developed OA, but the control DBA/1 male mice had more pronounced enthesopathic arthritis. Both DBA/1 and B10.Q strains are susceptible to the induction of CIA, and CIX deficiency in both strains led to the development of a more severe arthritis than in the controls. Induction of arthritis with monoclonal antibodies against CII led to earlier arthritis in the paws and also involved the knee joints. The C1I-specific antibodies bound to cartilage better in CIX-deficient mice than in wild type animals. This finding demonstrates that a lack of CIX in cartilage leads to an increased accessibility of structures for antibody binding and thus makes the joints more vulnerable to an inflammatory attack. These observations accentuate the importance of cartilage stability; disrupted cartilage due to genetic disorders might be more accessible and vulnerable to autoimmune attack by pathogenic antibodies.
= collagen-antibody-induced arthritis
= type II collagen
= type IX collagen
= collagen-induced arthritis
= cartilage oligomeric matrix protein
= enzyme-linked immunosorbent assay
= interferon
= osteoarthritis
= phosphate-buffered saline
= polymerase chain reaction
= rheumatoid arthritis
= stress-induced arthritis.
We thank Carlos Palestro, Lennart Lindström, Rebecca Lindqvist, Isabelle Bohlin and Sandy Liedholm for taking care of the animals, and Emma Mondoc for histopathological analysis. The work was supported by grants from the Anna Greta Crafoord Foundation for Rheumatological Research, King Gustaf V:s 80-year Foundation, the Kock and Österlund Foundations, the Swedish Association against Rheumatism and the Swedish Science Research Council.
Authors' Affiliations
- Diab M, Wu JJ, Eyre DR: Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites. Biochem J. 1996, 314: 327-332.PubMed CentralView ArticlePubMedGoogle Scholar
- Van der Rest M, Mayne R: Type IX collagen proteoglycan from cartilage is covalently cross-linked to type II collagen. J Biol Chem. 1988, 263: 1615-1618.PubMedGoogle Scholar
- Wu JJ, Woods PE, Eyre DR: Identification of cross-linking sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type IX bonding. J Biol Chem. 1992, 267: 23007-23014.PubMedGoogle Scholar
- Shaw LM, Olsen BR: FACIT collagens: diverse molecular bridges in extracellular matrices. Trends Biochem Sci. 1991, 16: 191-194. 10.1016/0968-0004(91)90074-6.View ArticlePubMedGoogle Scholar
- Nakata K, Ono K, Miyazaki J, Olsen BR, Muragaki Y, Adachi E, Yamamura K, Kimura T: Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing α1(IX) collagen chains with a central deletion. Proc Natl Acad Sci USA. 1993, 90: 2870-2874. 10.1073/pnas.90.7.2870.PubMed CentralView ArticlePubMedGoogle Scholar
- Fassler R, Schnegelsberg PN, Dausman J, Shinya T, Muragaki Y, McCarthy MT, Olsen BR, Jaenisch R: Mice lacking α1(IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci USA. 1994, 91: 5070-5074. 10.1073/pnas.91.11.5070.PubMed CentralView ArticlePubMedGoogle Scholar
- Briggs MD, Choi H, Warman ML, Loughlin JA, Wordsworth P, Sykes BC, Irven CM, Smith M, Wynne-Davies R, Lipson MH, et al: Genetic mapping of a locus for multiple epiphyseal dysplasia (EDM2) to a region of chromosome 1 containing a type IX collagen gene. Am J Hum Genet. 1994, 55: 678-684.PubMed CentralPubMedGoogle Scholar
- Muragaki Y, Mariman EC, van Beersum SE, Perala M, van Mourik JB, Warman ML, Olsen BR, Hamel BC: A mutation in the gene encoding the α2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (EDM2). Nat Genet. 1996, 12: 103-105. 10.1038/ng0196-103.View ArticlePubMedGoogle Scholar
- Holmdahl R, Jansson L, Gullberg D, Rubin K, Forsberg PO, Klareskog L: Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. Clin Exp Immunol. 1985, 62: 639-646.PubMed CentralPubMedGoogle Scholar
- Mo JA, Scheynius A, Holmdahl R: Antibody recognition of mouse cartilage in vivo; epitope and idiotype-specific binding and inhibition. Scand J Immunol. 1994, 39: 122-130.View ArticlePubMedGoogle Scholar
- Terato K, Hasty KA, Reife RA, Cremer MA, Kang AH, Stuart JM: Induction of arthritis with monoclonal antibodies to collagen. J Immunol. 1992, 148: 2103-2108.PubMedGoogle Scholar
- Nandakumar KS, Svensson L, Holmdahl R: Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol. 2003, 163: 1827-1837.PubMed CentralView ArticlePubMedGoogle Scholar
- Cremer MA, Ye XJ, Terato K, Griffiths MM, Watson WC, Kang AH: Immunity to type IX collagen in rodents: a study of type IX collagen for autoimmune and arthritogenic activities. Clin Exp Immunol. 1998, 112: 375-382. 10.1046/j.1365-2249.1998.00577.x.PubMed CentralView ArticlePubMedGoogle Scholar
- Stuart JM, Dixon FJ: Serum transfer of collagen-induced arthritis in mice. J Exp Med. 1983, 158: 378-392. 10.1084/jem.158.2.378.View ArticlePubMedGoogle Scholar
- Holmdahl R, Jansson L, Larsson A, Jonsson R: Arthritis in DBA/1 mice induced with passively transferred type II collagen immune serum. Immunohistopathology and serum levels of anti-type II collagen autoantibodies. Scand J Immunol. 1990, 31: 147-157.View ArticlePubMedGoogle Scholar
- Nandakumar KS, Backlund J, Vestberg M, Holmdahl R: Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther. 2004, 6: R544-550. 10.1186/ar1217.PubMed CentralView ArticlePubMedGoogle Scholar
- Seki N, Sudo Y, Yoshioka T, Sugihara S, Fujitsu T, Sakuma S, Ogawa T, Hamaoka T, Senoh H, Fujiwara H: Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity. J Immunol. 1988, 140: 1477-1484.PubMedGoogle Scholar
- Holmdahl R, Vingsbo C, Malmstrom V, Jansson L, Holmdahl M: Chronicity of arthritis induced with homologous type II collagen (CII) in rats is associated with anti-CII B-cell activation. J Autoimmun. 1994, 7: 739-752. 10.1006/jaut.1994.1058.View ArticlePubMedGoogle Scholar
- Ranges GE, Sriram S, Cooper SM: Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J Exp Med. 1985, 162: 1105-1110. 10.1084/jem.162.3.1105.View ArticlePubMedGoogle Scholar
- Moder KG, Luthra HS, Kubo R, Griffiths M, David CS: Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the T cell receptor alpha beta framework. Autoimmunity. 1992, 11: 219-224.View ArticlePubMedGoogle Scholar
- Corthay A, Johansson A, Vestberg M, Holmdahl R: Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice. Int Immunol. 1999, 11: 1065-1073. 10.1093/intimm/11.7.1065.View ArticlePubMedGoogle Scholar
- Hietala MA, Nandakumar KS, Persson L, Fahlen S, Holmdahl R, Pekna M: Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis. Eur J Immunol. 2004, 34: 1208-1216. 10.1002/eji.200424895.View ArticlePubMedGoogle Scholar
- Nandakumar KS, Andren M, Martinsson P, Bajtner E, Hellstrom S, Holmdahl R, Kleinau S: Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB. Eur J Immunol. 2003, 33: 2269-2277. 10.1002/eji.200323810.View ArticlePubMedGoogle Scholar
- Corthay A, Hansson AS, Holmdahl R: T lymphocytes are not required for the spontaneous development of entheseal ossification leading to marginal ankylosis in the DBA/1 mouse. Arthritis Rheum. 2000, 43: 844-851. 10.1002/1529-0131(200004)43:4<844::AID-ANR15>3.0.CO;2-B.View ArticlePubMedGoogle Scholar
- Matthys P, Lories RJ, De Klerck B, Heremans H, Luyten FP, Billiau A: Dependence on interferon-γ for the spontaneous occurrence of arthritis in DBA/1 mice. Arthritis Rheum. 2003, 48: 2983-2988. 10.1002/art.11273.View ArticlePubMedGoogle Scholar
- Lories RJ, Derese I, Luyten FP: Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis. J Clin Invest. 2005, 115: 1571-1579. 10.1172/JCI23738.PubMed CentralView ArticlePubMedGoogle Scholar
- van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB: Transforming growth factor-β1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest. 1994, 71: 279-290.PubMedGoogle Scholar
- Resnick D, Niwayama G: Entheses and enthesopathy. Anatomical, pathological, and radiological correlation. Radiology. 1983, 146: 1-9.View ArticlePubMedGoogle Scholar
- Pottenger LA, Phillips FM, Draganich LF: The effect of marginal osteophytes on reduction of varus-valgus instability in osteoarthritic knees. Arthritis Rheum. 1990, 33: 853-858.View ArticlePubMedGoogle Scholar
- Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A: Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 1991, 19: 4293-PubMed CentralView ArticlePubMedGoogle Scholar
- Holmdahl R, Carlsen S, Mikulowska A, Vestberg M, Brunsberg U, Hansson A-S, Sundvall M, Jansson L, Pettersson U: Genetic analysis of mouse models for rheumatoid arthritis. Human Genome Methods. Edited by: Adolph KW. 1997, New York: CRC Press, 215-238.Google Scholar
- Holmdahl R, Jansson L, Andersson M, Jonsson R: Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice. Clin Exp Immunol. 1992, 88: 467-472.PubMed CentralView ArticlePubMedGoogle Scholar
- Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H: Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum. 1986, 29: 400-410.View ArticlePubMedGoogle Scholar
- Karlsson R, Mo JA, Holmdahl R: Binding of autoreactive mouse anti-type II collagen antibodies derived from the primary and the secondary immune response investigated with the biosensor technique. J Immunol Methods. 1995, 188: 63-71. 10.1016/0022-1759(95)00203-0.View ArticlePubMedGoogle Scholar
- Schulte S, Unger C, Mo JA, Wendler O, Bauer E, Frischholz S, von der Mark K, Kalden JR, Holmdahl R, Burkhardt H: Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils. J Biol Chem. 1998, 273: 1551-1561. 10.1074/jbc.273.3.1551.View ArticlePubMedGoogle Scholar
- Holmdahl R, Jansson L, Andersson M, Larsson E: Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis. Immunology. 1988, 65: 305-310.PubMed CentralPubMedGoogle Scholar
- Jonsson R, Karlsson AL, Holmdahl R: Demonstration of immunoreactive sites on cartilage after in vivo administration of biotinylated anti-type II collagen antibodies. J Histochem Cytochem. 1989, 37: 265-268.View ArticlePubMedGoogle Scholar
- Holmdahl R, Mo JA, Jonsson R, Karlstrom K, Scheynius A: Multiple epitopes on cartilage type II collagen are accessible for antibody binding in vivo. Autoimmunity. 1991, 10: 27-34.View ArticlePubMedGoogle Scholar
- Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R: The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol. 1985, 87: 27-45.PubMedGoogle Scholar
- Stoop R, van der Kraan PM, Buma P, Hollander AP, Billinghurst RC, Poole AR, van den Berg WB: Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice. Arthritis Rheum. 1999, 42: 2381-2389. 10.1002/1529-0131(199911)42:11<2381::AID-ANR17>3.0.CO;2-E.View ArticlePubMedGoogle Scholar
- Sandell LJ, Aigner T: Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res. 2001, 3: 107-113. 10.1186/ar148.PubMed CentralView ArticlePubMedGoogle Scholar
- Bajtner E, Nandakumar KS, Engström Å, Holmdahl R: B cell fine specificity response to triple helical type II collagen along the disease course of chronic relapsing collagen induced arthritis. Arthritis Res Ther. 2005, 7: 1148-57. 10.1186/ar1800.View ArticleGoogle Scholar
- Wernhoff P, Unger C, Bajtner E, Burkhardt H, Holmdahl R: Identification of conformation-dependent epitopes and V gene selection in the B cell response to type II collagen in the DA rat. Int Immunol. 2001, 13: 909-919. 10.1093/intimm/13.7.909.View ArticlePubMedGoogle Scholar
- Amirahmadi SF, Pho MH, Gray RE, Crombie DE, Whittingham SF, Zuasti BB, Van Damme MP, Rowley MJ: An arthritogenic monoclonal antibody to type II collagen, CII-C1, impairs cartilage formation by cultured chondrocytes. Immunol Cell Biol. 2004, 82: 427-434. 10.1111/j.0818-9641.2004.01267.x.View ArticlePubMedGoogle Scholar
- Gray RE, Seng N, Mackay IR, Rowley MJ: Measurement of antibodies to collagen II by inhibition of collagen fibril formation in vitro. J Immunol Methods. 2004, 285: 55-61. 10.1016/j.jim.2003.11.010.View ArticlePubMedGoogle Scholar
- Amirahmadi SF, Whittingham S, Crombie DE, Nandakumar KS, Holmdahl R, Mackay IR, van Damme MP, Rowley MJ: Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells. Arthritis Rheum. 2005, 52: 1897-1906. 10.1002/art.21097.View ArticlePubMedGoogle Scholar
- Burkhardt H, Koller T, Engstrom A, Nandakumar KS, Turnay J, Kraetsch HG, Kalden JR, Holmdahl R: Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse. Arthritis Rheum. 2002, 46: 2339-2348. 10.1002/art.10472.View ArticlePubMedGoogle Scholar
- Briggs MD, Hoffman SM, King LM, Olsen AS, Mohrenweiser H, Leroy JG, Mortier GR, Rimoin DL, Lachman RS, Gaines ES, et al: Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Nat Genet. 1995, 10: 330-336. 10.1038/ng0795-330.View ArticlePubMedGoogle Scholar
- Jakkula E, Lohiniva J, Capone A, Bonafe L, Marti M, Schuster V, Giedion A, Eich G, Boltshauser E, Ala-Kokko L, et al: A recurrent R718W mutation in COMP results in multiple epiphyseal dysplasia with mild myopathy: clinical and pathogenetic overlap with collagen IX mutations. J Med Genet. 2003, 40: 942-948. 10.1136/jmg.40.12.942.PubMed CentralView ArticlePubMedGoogle Scholar
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We don't care for the groove along the back of the top, or for the black flat top., but we had no option. We would have preferred white or grey, but that's...Read complete review
We don't care for the groove along the back of the top, or for the black flat top., but we had no option. We would have preferred white or grey, but that's all cosmetic. The stove is great. That's why we chose Frigidaire.
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I've had mine a few years, but upon initial delivery , the oven door didn't look like it closed all the way. I wasn't home at the time of it's arrival but my wife...Read complete review
I've had mine a few years, but upon initial delivery , the oven door didn't look like it closed all the way. I wasn't home at the time of it's arrival but my wife was surprised as it was a gift and was eager to use it. After contacting the dealer, they sent a repair guy out to adjust it. It looked better at the time , but slowly started to show a gap at the top of the door. I shouldn't have accepted delivery and made more of a hissy fit until resolved, but that's on me. It's gotten so bad now that I'm about an eighth of an inch before the oven light comes on when the door is opening. Also being a bisque color, I can see the darkened marks on top of the door due to heat escaping. I contacted other dealers to see if this was a common problem, and they tell me it's because it's not new. The last appliance person I had check it out told me I needed oven door springs. I told him to order them and I would pay him to install them. He then said he would rather replace the oven door with another one he had in his shop, as the springs are a pain to change. The only problem is the replacement door is black. I didn't even bring that up to my wife. I personally hate electric ranges, but that's my only option in my present home. I will never deal with the appliance store who sold me this unit, and I will never buy a Frigidaire appliance again.
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Great item for the money
By indybenji
from Indianapolis, IN
Comments about Frigidaire 30" FFEF3013LB Black Freestanding Electric Range:
I have had this stove in my home for over a month. I could not have purchased a more economical stove with features provided.. I just wish the storage drawer underneath was a little bigger. Everything else is just wonderful.
Bottom Line Yes, I would recommend this to a friend
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Best ever glass top range.
By Dotjane
from Magnolia, AR, United States
This was my Christmas gift along with all of my kitchen appliances that are also Frigidaire. It is so much easier to clean than the glass stove top I already had. I love the oven being wider too! I can't say enough about this appliance. Thanks so much for making them easier to clean!
Great range
By Jesticles
from Franklinton, NC, United States
This is an amazing range for the price, highly recommend.
Exceeds expectations
By rpatel
from Philadelphia, PA, United States
I recently purchased a condo where a gas stove was not a possibility. I was so discouraged, however because I fell in love with the condo, I decided to put the stove issue aside. I've been using this range for over two months now and can honestly say it has not disappointed!! The head is distributed evenly, and everything cooks great!
Looks great..works even better
By Corozzo312
from Grandview, MO, United States
Never had Frigidaire range..wish I did sooner. Love it's sleek look. Great space. Glasstop burners and I just discovered the smaller white circle on one of the burners is so you can use half the burner for smaller pot or whole burner for big pot. Cool energy saving feature. Can say anything even close to neutral about this appliance, I love it.
Great Stove, love the surface
By msdezim
from Forney, TX, United States
Great overall stove, love the surface especially, easy clean up.
Beautiful Stove
By donna60
from Fort Pierce, FL
This was purchased to replace a very old range. What a pleasure! Oven heats up quickly, stove top is easy to clean, easy to use. Haven't tried to self clean yet!
I'm in love (with an oven)
By willinwashington
from Seattle, WA, United States
I bought this oven a month ago and am so happy with it! It was such a great and affordable price! The glass surface heats almost instantly and the oven preheats extremely fast! I highly recommend
well worth the price
By Vernellnella
from Columbus, GA, United States
I bought the oven in November, and I was quite surprised that I liked it so much better than my oven that put me down. It bakes great, as I bake cakes on a regular basis. The stove top is taking some getting used to but I am beginning to like that too.
stove is nice looking, fit the kitchen perfectly.
By judy51
from milford ct
Love the stove, temp is spot on, love cooking on my new stove and oven
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