text:
Recently, several genome-wide association studies (GWAS) have been published for late onset Alzheimer's disease (LOAD). Each GWAS that has been published to date has mapped the Apolipoprotein E (APOE) locus as the strongest LOAD risk signal within the human genome. This has led us and others to hypothesize that this large signal can 1. Overwhelm other smaller effects that are in epitasis with the APOE E4 locus and 2. Be de-convoluted into multiple risk loci mapping to the same area of the genome. The first hypothesis is plausible, considering that in our previous GWAS we mapped an effect that was only present in APOE E4 positive individuals. The second hypothesis is also valid in that this type of effect (i.e. multiple risk loci mapping to the same region of the genome) has been seen in other neurological diseases. For example, for Fronto-temporal Dementia Linked to Chromosome 17 (FTDP-17), mutations in both the microtubule associated protein Tau gene (MAPT) as well as Progranulin (PRGN) have been found. Both MAPT and PRGN map within the same linkage peak on chromosome 17. Thus, we propose to leverage our genome-wide and Next Generation Sequencing (NGS) genetic data, as well as transcriptome and proteome datasets to map novel risk loci for LOAD that are acting either in epistasis with or independently of the APOE E4 allele. We propose the following: To test our APOE E4 independent effects, we will perform additional NGS sequencing within the same region of chromosome 19 to capture additional effects (Aim 1a). We will also genotype the variants we found from our NGS in additional case control samples to determine whether they act independently of APOE E4 to increase risk for disease (Aim 1b). To follow our APOE E4 epistatic effects, SNPs which we found to act in conjunction with APOE E4 will be followed by examining an additional cohort (Aim 2a) as well as sequencing within the region to find additional variants (Aim 2b). Finally, we will map the downstream effects of any variants we map in Aims 1 or 2 by examining transcript expression and protein profiles (Aim 3), Our collaboration possesses the unique skills and datasets to perform this work. Drs. Huentelman and Myers have worked together for the greater part of their careers and have co-authored many publications using similar techniques as those proposed in this application. They have access to a unique cohort of ~ 1600 neuropathologically verified individuals, which will allow for both the analysis of risk variation as well as the downstream changes of those variants. They have recruited an additional cohort of ~ 18,000 clinically characterized samples from the University of Cardiff to replicate any effects. They also have access to both the computational power (48-core / 576GB memory computer and a separate 2,700-core cluster through Tgen and one of 5000 CPU at the University of Miami) as well as the expertise to execute the bioinformatics analysis involved in all Aims.
Our proposal seeks to understand whether there are additional risk genes and variants which act either independently or in synergy with the APOE E4 gene variant on chromosome 19. We will examine 1) Genome- wide association data, and 2) Novel DNA changes we have found through Next Generation and Sanger sequencing analysis looking at both risk for Alzheimer's disease as well as changes in gene and protein expression. We anticipate that several of these novel variants are involved in risk as well as changing the downstream function of their target genes.
|Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606
|Lim, Andrew S P; Srivastava, Gyan P; Yu, Lei et al. (2014) 24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. PLoS Genet 10:e1004792
|Macias, Mimi P; Gonzales, Amanda M; Siniard, Ashley L et al. (2014) A cellular model of amyloid precursor protein processing and amyloid-? peptide production. J Neurosci Methods 223:114-22
|Myers, Amanda J; Williams, Leanne; Gatt, Justine M et al. (2014) Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress. J Psychiatr Res 59:93-100
|Dean 3rd, Douglas C; Jerskey, Beth A; Chen, Kewei et al. (2014) Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. JAMA Neurol 71:11-22


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Hot Humpty Dumpty Salad In Bread Boat
|Vienna bread loaf
|Hard-cooked eggs
|6 , coarsely diced
|Diced celery
|1 1⁄4 Cup (20 tbs)
|Chopped stuffed green olives
|1⁄2 Cup (8 tbs)
|Chopped onion
|1⁄4 Cup (4 tbs)
|1 Clove (5 gm), minced
|3⁄4 Teaspoon
|1⁄4 Teaspoon
|1⁄2 Cup (8 tbs)
|Prepared mustard
|2 Tablespoon
|Melted butter/Margarine
|1 Tablespoon
Cut top crust off bread and reserve for lid.
Hollow out loaf to within 1 inch of bottom.
Crumble enough bread (taken from center) to make 1 cup crumbs; add eggs, celery, olives, onion, garlic, and seasonings.
Combine mayonnaise and mustard; add to egg mixture and toss lightly.
Fill "boat"; replace top; brush loaf with butter.
Wrap in foil.
Bake in hot oven (425°) 30 to 35 minutes, or till heated through.
Top salad with egg and olive slices.
To match picture serve on tray with lettuce cups filled with dill-pickle sticks, rosy radishes, stuffed green olives and Carrot Crisps .
Cut loaf in 8 slices and serve hot with buttered roasting ears, steaming coffee.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 2759 Calories from Fat 1406
% Daily Value*
Total Fat 155 g239%
Saturated Fat 29 g145.1%
Trans Fat 0 g
Cholesterol 1561.1 mg520.4%
Sodium 6542.8 mg272.6%
Total Carbohydrates 248 g82.7%
Dietary Fiber 4.2 g16.9%
Sugars 8.6 g
Protein 96 g192.1%
Vitamin A 61.5% Vitamin C 16%
Calcium 27.1% Iron 27.8%
*Based on a 2000 Calorie diet

subset: commoncrawl


text:
What have you all ordered for next year? What do you consider some of the
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I have been very conservative this fall and bought only 'Revolution'.
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text:
DMN Modular Netgame is a videogame based on a classic Spanish game: "Dominó"
The Dominó is a board game where two o four people can play, one player vs.
other or two partners vs. other two. The player who runs out of dominoes wins.
User Reviews
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text:
Are you looking for Toilet Seats in Singapore? Hotfrog showcases more than 50 popular businesses related to Toilet Seats in Singapore! Find a specific region or suburb using the left navigation.
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- 01/06/2013
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text: Home Gallery Video Milk Farmer Milk: Farmer Published on Mar 22, 2006 Editor's Pick Rate this Ad You must be registered to rate the ad. Please Login or Register Now About CreditsDateMar 22, 2006Music Company:Beacon Street StudiosVFX:Brickyard VFXEditorial Company:Mackenzie-CutlerProduction Company:Moxie PicturesClient:MilkCreative Director:Jeff GoodbyCopywriter:Pat McKayArt Director:Feh TartyAgency Broadcast Producer:Alex LindDirector:Frank TodaroDirector of Photography:Neil ShapiroExecutive Producer:Robert FernandezEditor:Jun DiazExecutive Producer (Editorial):Melissa MillerMusic Executive Producer:Andrew FeltensteinComposer:Andrew FeltensteinComposer:John NauComposer:Craig DobbinSound Designer:Brian ChapmanAgency:Goodby Silverstein & Partners Tagsbeverage GenreComedy/Dialog Latest Creativity News on Ad Age Community Films Signs Young, Winecoff Joins Epoch Murillo to Lead McDonald's Team at Alma, Mariano Joins Zulu Alpha Kilo Have You Entered Our 40 Under 40 Contest Yet? Related work Milk: The Rock -- Super Bowl XLVII Deutsch New York Milk: Get The Glass Goodby Silverstein & Partners California Milk Processor Board: The Trailer Goodby Silverstein & Partners


text:
Shin Megami Tensei: Devil Summoner 2: Raidou Kuzunoha vs. King Abaddon PlayStation 2
- Publisher: Atlus Co.
- Release Date: May 12, 2009
- Summary: A new threat to Japan's Capital calls for the return of its case-solving, tube-slinging Devil Summoner: Raidou Kuzunoha the 14th. When a woman walks into the Narumi Detective Agency and asks to find a man, Raidou's boss is reluctant to accept, but soon it's clear there's more to the caseA new threat to Japan's Capital calls for the return of its case-solving, tube-slinging Devil Summoner: Raidou Kuzunoha the 14th. When a woman walks into the Narumi Detective Agency and asks to find a man, Raidou's boss is reluctant to accept, but soon it's clear there's more to the case than it seems on the surface. It isn't long before Raidou is on the trail of crooked gamblers, masked ninja, and strange insects... a trail leading him inexorably to the mysterious King Abaddon. Massively upgraded battle system - Advancements to the battle mechanics include a MAG balancing system, dodge and hide abilities, and the ability to command two demons in combat. Use the retooled Weapon Alchemy system to create new swords with unique special attacks. Deeper demon integration - Demon negotiation returns with more than twice the number of demons to attempt to recruit to your side. Create more powerful demons through fusion and skill transfer. Control two demons in battle and choose from more tactical options. [Atlus USA]… Expand
- Developer: Atlus Co.
- Genre(s): Role-Playing
- Cheats: On GameFAQs
- More Details and Credits »
Score distribution:
Positive: 20 out of 23
Mixed: 3 out of 23
Negative: 0 out of 23
While virtually identical to its predecessor, the total revamp of the battle system makes Devil Summoner 2 more than "more of the same."
Devil Summoner 2 might not have as many redeeming qualities as some of the later Persona titles, and it might not even tie the two chunks of the game together as well as those titles do either, but that doesn't mean that the entire game isn't a solid investment from the moment that it starts.
A deep, engaging experience, with a captivating plot and a great combat system. If your PS2 is sitting in a closet somewhere it's time to dig it out, because the system's got one more must-play RPG.
Playstation: The Official Magazine (US)It's hard not to be taken in by the eerie lullaby of this world's secrets. [July 2009, p.82]
Atlus seem to be masters of creating brilliant sequels without changing more than a few textures and a new script. Persona 4 was an example of this, and Devil Summoner 2 seems to continue that tradition.
Devil Summoner 2 is a huge improvement over the first and another great installment in the Shin Megami Tensei series that both newcomers and series veterans can enjoy.
MegaTen's experiment in action role-playing continues, but it remains a flawed and repetitive ride.
Score distribution:
Positive: 1 out of 1
Mixed: 0 out of 1
Negative: 0 out of 1
Jul 31, 2011For those who played the last one will notice everything from has been vastly improved. The great characters and interesting environmentsFor those who played the last one will notice everything from has been vastly improved. The great characters and interesting environments return, the dialogue has been improved with choices that actually mean something although their effects are limited. Like last game it can be beat in a weekend making replay runs not all that tedious. Combat has been improved and you can use two demons in battle instead of one. Demon fusing also had an upgrade and it's very easy to get almost any demon overpowered moves making it a little bit too easy once you learn how to abuse the demon fusing. However the real test lies in completing the optional cases. The story like most Shin Megami Tensei games is suburb and there is very little wrong with it. However combat while fun can become dull and some dungeons are a choir to go through. Not to mention you'll see a lot of insects, but it's still a fun little game that will easily make for an enjoyable weekend.… Collapse
Awards & Rankings
#13 Most Discussed PS2 Game of 2009
#6 Most Shared PS2 Game of 2009


text:
This luxurious collection is a delicious way to recall generations of pleasure with a sumptuous selection of 28 of our most iconic, unforgettable Belgian chocolate creations.
Brighten up your day with the BonBons collection by Neuhaus! Our Maître Chocolatier has created 5 milk and dark chocolate pralines shaped in small cubes in traditional flavors with contemporary styling.
The subtlety of Neuhaus' exclusive recipes in refined chocolate Carrés, wrapped in a range of vibrant colours. Discover the 15 varieties where the original chocolate has been infused with fruity or spicy flavours.
Neuhaus, the inventor of the praline, stands for superior quality and timeless elegance since 1857. The Maître Chocolatier creates exquisite chocolates using outstanding ingredients and drawing on its master craftsmanship, experience and passion. Since Jean Neuhaus opened his first shop in the prestigious Queen's Gallery in Brussels, Neuhaus has gone on to garner international acclaim for their exclusive chocolates and luxurious gift packaging.
Business gift services
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text:
Child abuse and its health effects—research paper topics
According to ChildHelp.org, a report of child abuse is made every 10 seconds. Child abuse can take many forms—from sexual abuse to refusal of medical treatment, from verbal abuse to neglect. No matter what types of abuse occur, the health effects, both physical and mental, can be long lasting.
Research paper topics could explore not only means of preventing child abuse, but also the health consequences for the abused, and other factors that impact the welfare of children. Read more →


text:
At Full Speed: Hong Kong Cinema in a Borderless World
Edited by Esther Yau
Format: Paperback
Normal Price: $45.95
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At Full Speed: Hong Kong Cinema in a Borderless World by Esther Yau
Book DescriptionBreathtaking swordplay and nostalgic love, Peking opera and Chow Yun-fat's cult followers -- these are some of the elements of the vivid and diverse urban imagination that find form and expression in the thriving Hong Kong cinema. All receive their due in At Full Speed, a volume that captures the remarkable range and energy of a cinema that borrows, invents, and reinvents across the boundaries of time, culture, and conventions.At Full Speed gathers film scholars and critics from around the globe to convey the transnational, multilayered character that Hong Kong films acquire and impart as they circulate worldwide. These writers scrutinize the films they find captivating: from the lesser known works of Law Man and Yuen Woo Ping to such film festival notables as Stanley Kwan and Wong Kar-wai, and from the commercial action, romance, and comedy genres of Jackie Chan, Peter Chan, Steven Chiau, Tsui Hark, John Woo, and Derek Yee to the attempted departures of Evans Chan, Ann Hui, and Clara Law.In this cinema the contributors identify an aesthetics of action, gender-flexible melodramatic excesses, objects of nostalgia, and globally projected local history and identities, as well as an active critical film community. Their work, the most incisive account ever given of one of the world's largest film industries, brings the pleasures and idiosyncrasies of Hong Kong cinema into clear close-up focus even as it enlarges on the relationships between art and the market, cultural theory and the movies.
Buy At Full Speed: Hong Kong Cinema in a Borderless World book by Esther Yau from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780816632350
(253mm x 178mm x 19mm)
Pages: 272
Imprint: University of Minnesota Press
Publisher: University of Minnesota Press
Publish Date: 9-May-2001
Country of Publication: United States
Books By Author Esther Yau
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text:
SCID-Xl is a catastrophic disease of childhood caused by mutations in the common gamma chain (YC) leading to defects in cytokine signaling that result in profound deficiencies in both cellular and humoral immunity. Patients that have a matched sibling donor for allogeneic transplant do very well with a greater than 90% long-term disease free survival. However, most patients do not have a matched sibling donor available and typically are treated using a haploidentical, parental transplant. These patients do significantly less well with a long term survival ranging between 60 and 75%. Furthermore, persistent immune defects are present in about 50 to 60 % of the survivors of haploidentical transplants. For these children who lack a matched sibling donor, gene therapy is being developed as an alternate primary therapy and as salvage for allogeneic transplant failures. Prior trials in France, the UK, and in the US have used retroviral vectors developed from the Moloney Leukemia Virus (MLV) in which the y{c} cDNA was driven from the strong viral enhancer/promoter present in the long terminal repeat (LTR). These trials have yielded clear proof of efficacy by showing that the majority of patients had significant immune reconstitution following the gene transfer procedure. However, 5 out of 23 patients have developed T cell leukemia due to transcriptional activation of cellular proto-oncogenes from the strong viral enhancer present in the MLV LTR. We now seek to avoid this complication by using a self-inactivating (SIN) lentiviral vector which contains an internal cellular promoter and chromatin insulator fragments flanking the transcriptional cassette. We have tested this CL20i4-EF1a-hy{c}-OPT vector in preclinical experiments that have confirmed the potential safety and efficacy of this configuration. We have also created a high titer, stable producer cell line for GMP production and have generated a Master Cell Bank in our GMP facility. We now propose two clinical protocols to study the use of this vector in either newly diagnosed patients less than one year old (LVXSCID-ND) or in older children that have failed previous treatment or who present later in life with milder symptoms (LVXSCID-OC). We hypothesize that this lentiviral vector-based approach will provide effective treatment and will be safer than the previous MLV-based vectors. These companion clinical trials should yield a great deal of information about gene therapy for SCID-X1 and more generally about the use of lentiviral vectors for stem cell-targeted, human gene therapy.
This project will test a new method for treating patients with x-linked severe combined immunodeficiency based on using lentiviral vectors and may identify a new treatment option that could be used for the majority of these patients. It is also possible that this study could provide more general information about lentiviral vectors that will lead to new therapies for other types of blood and immune system disorders.
|Yu, Hui; Neale, Geoffrey; Zhang, Hui et al. (2014) Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo. Blood 124:1737-47
|Jackson, Shaun W; Scharping, Nicole E; Kolhatkar, Nikita S et al. (2014) Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J Immunol 192:4525-32
|Griffith, Linda M; Cowan, Morton J; Notarangelo, Luigi D et al. (2014) Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol 133:335-47
|Treanor, Louise M; Zhou, Sheng; Janke, Laura et al. (2014) Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med 211:701-13
|De Ravin, Suk See; Gray, John T; Throm, Robert E et al. (2014) False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector. Mol Ther 22:244-5
|Nienhuis, Arthur W (2013) Development of gene therapy for blood disorders: an update. Blood 122:1556-64
|Zhou, Sheng; Ma, Zhijun; Lu, Taihe et al. (2013) Mouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vector. PLoS One 8:e62333
|Wilber, Andrew; Nienhuis, Arthur W; Persons, Derek A (2011) Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities. Blood 117:3945-53
|Wilber, Andrew; Hargrove, Phillip W; Kim, Yoon-Sang et al. (2011) Therapeutic levels of fetal hemoglobin in erythroid progeny of ýý-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood 117:2817-26
|Kim, Yoon-Sang; Wielgosz, Matthew M; Hargrove, Phillip et al. (2010) Transduction of human primitive repopulating hematopoietic cells with lentiviral vectors pseudotyped with various envelope proteins. Mol Ther 18:1310-7
Showing the most recent 10 out of 136 publications


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Please e-mail us at firstname.lastname@example.com before returning. Products can be returned for size exchange. Handling fee 5$ domestic. Contact us for international returns.


text:
Stone & Leigh Teaberry Lane Convertible Crib
$ 699.00
Brand Stone & Leigh
Special order item, please allow 8-10 weeks for delivery. Call store for more information.
Taking you from the nursery to high school graduation and all the years in between, the Teaberry Lane Built to Grow Crib adjusts easily from crib to full size bed—your adjustment, however, may not be so easy. Available in a rich Midnight Cherry or Stardust White finish with an adjustable height metal frame. Convertible kits (sold separately) are available when you are ready to transition from a crib to a full size bed.


text:
Quality Assurance Manager
- Employer
- Reed Scientific
- Location
- Wales
- Salary
- Negotiable
- Posted
- Nov 30, 2012
- Closes
- Dec 28, 2012
- Ref
- 22337987
- Contact
- Dawod Kaaba
- Discipline
- Chemistry, Industrial Chemistry
- Result Type
- Jobs
- Position Type
- Permanent
- Hours
- Full Time
The Quality Assurance Manager will contribute to the effectiveness of the Quality team through monitoring and keeping up to date on all legal changes and developments in the EU and ensuring such changes are communicated to all affected parts of the business and suppliers. They will look to continuously improve the performance of the Global Quality Assurance team through changes and development of their working procedures and knowledge.
The core areas of responsibility are;
* Ensuring products are tested/documentation obtained so that the product is safe and can be sold
* Dealing with relevant Enforcement Authorities in European Union over alleged breaches of legislation
* Providing training on legal requirements to Buyers/Suppliers as required
* Order approval in European Union
* Monitoring and producing legal updates to the team
* Supporting and assisting the North America quality function as necessary and when required
The Quality Assurance Manager must ensure that the products identified and purchased by Buying meet all the legal requirements for the areas where they are being purchased for, to ensure the sale will not result in legal action by the regulatory authorities, Intellectual Property action by the IP holder and that customers are satisfied with their purchases.
The job holder must have a Chemistry related degree with Quality Assurance experience in the retail industry or a test house/laboratory, and experience of meeting client deadlines.
Excellent written and verbal communication skills are essential. The job holder will need to communicate with personnel outside of the Quality group, with external clients, in order to ensure timely completion of business demands and customer service.Reed Specialist Recruitment Limited is an employment agency and employment business.


text:
French installation artist Felicie d'Estienne d'Orves will be at the V&A's Digital Design Drop-in tomorrow at the Sackler Centre Digital Studio, V&A tomorrow.
Key examples of D'Estienne d'Orves' work include ' The Gong': a resonant, and pulsating work from her Cosmos Series and 'The Monolithe' (commissioned by Nuits Blanches in 2008) which stands like a futuristic needle-point surrounded by ancient spiritual drama.
Click here or on the image to see 'The Monolithe' in pictures
For more information about the V&A's digital drop-ins visit www.vam.ac.ukReuse content


text:
after replacing my tires the steering wheel started to tremble...I also replaced my rims ,struts, cv joints ,wheel bearings, brakes and had an alignment. I have been back to the shop where I bought the tires from several times. while they cannot find anything wrong with my car they are still insisting that the tires are not the problem
Asked by for the 1995 Toyota Celica


text:
Angela Knight has a talent for defending horribly unpopular causes. The chief executive of the British Bankers Association (BBA) has become a media-fixture as a rare advocate for an industry that sometimes seems indefensible. She was at it again last week, rounding on EU plans to crack down on bonuses, and she makes no apology for doing so.
"A solution agreed at the EU is not an international solution unless it is also agreed with the other G20 members," she says. "We need to look across the Atlantic to the US, and east towards Asia, to ensure changes are imposed sensibly everywhere. If they are not, then the result will be significant difficulties for businesses in Europe and for the many hundreds of thousands of jobs that depend on the financial services industry."
Unpopular causes, it seems, are Knight's thing: for the final two years of her political career she was a Treasury minister in John Major's despised government. And before she entered Parliament, she was a Tory councillor in what was known as the socialist republic of Sheffield.
"Politics does assist you in difficult situations. You get used to hostility," she says when I ask if this was useful preparation for where she is now.
"When I got elected to Parliament, I found it difficult to be speaking in a situation where people actually listened to you. I'd come from one where their whole objective when you were making a speech was to find ways to shut you up, from pulling away your microphone to simply shouting over you. So moving to an environment where people were prepared to listen was extraordinary. I suppose I'm taking a long time to say that the blooding of my younger years has helped in the difficult scenario we have found ourselves in."
We meet in her office on a Friday lunchtime between two of the many meetings that make up a hectic scheduled in which a 12-hour day is considered "a short one for me". It's an appealingly untidy space, with papers strewn here and there, humanised by a large, bright-yellow, cuddly duck she calls Quackers. "Oh dear, we should have got rid of that before this," she says to her PR man, when I point it out. "I won him in a raffle," she says. "Stroking him is as good as having a worry ball."
Perhaps it isn't surprising that Knight needs a worry ball. She took over at the BBA on 1 April 2007, just a few months before all hell broke loose. She's been running at breakneck speed just to keep up ever since.
So how's it going now? "There are so many things to keep up with, such as the Independent Banking Commission [which may break them up], regulatory changes, bank lending, things like that. Then we have the big international piste and what Europe decides to do."
Not that this is a complaint: "I have a tremendously engaging job. The banking industry has to say: 'Look this is the way forward. We accept our responsibilities but let's see how we can put things back together.' "
I'm interested in how she views her old party now: While many of the slings and arrows fired at bankers have come from the Liberal Democrats, the Conservatives haven't exactly been shy. It was their leader, David Cameron, who said financiers should face "a day of reckoning" for the disasters of the past three years, though that was while he was in opposition.
Some would argue the Tories have been tougher than Labour. The previous government imposed a one-off tax on bankers' bonuses but never contemplated a banking commission or a permanent levy. The usually Euro-sceptic Tories were hardly falling over themselves to attack Friday's EU plans for a bonus crackdown either. "We have got hard rhetoric, it's true," says Knight. "But in some respects, the past government had a position to defend. If you're defending the actions you take it's different to if you're the newcomers saying we're going to review what's been done and look at our own measures.
"If the choice was to have a banking commission or not to have a banking commission, obviously we would prefer not to have one. But if we are going to question the whole way in which banking operates in the UK, it is better done in a dispassionate, independent way that will not be subject to the 'oh yes they should', 'oh no they shouldn't' rhetoric which is what has been running and running."
Knight believes that bankers should be defended. And it's usually she who has to do it. Plenty of multi-millionaire executives, in offices far better appointed than her's, are happy to let her take the flack.
She disagrees: "No that's not fair. I actually think that, you know, maybe when it was very hot.... But they have businesses to run, frankly. Now you do see the bank CEOs and their chairmen out discussing and explaining. They're on public platforms they take part in sessions, they appear in the media. Sometimes there are things, though, which I have to do. I have no criticism."
Much of what she says is unwelcome, she admits, "But that doesn't make it wrong. The banking industry may be responsible for banking, but it didn't run the country. It didn't spend huge amounts of taxpayers money on the assumption it would carry on coming in forever. We weren't in charge of the regulator. We didn't make monetary policy. If you try to park it all on the banks, it might be good in terms of blame, we are natural hate figures. But you're not going to make good policy. Someone has to say that.
"I just want to ensure that this country does not lose something so valuable to it simply because some of its members have got into difficulty, some but by no means all."
So synonymous has Knight become with the bankers' cause, it seems that she's been in post for a lot longer than three years. When I try to tease her into talking about the future, though, she refuses. Speculation linking her to a return to Government, perhaps from the House of Lords, draws no response.
"I want to see the banks through a difficult period. I want to see them into clear water," she says. That might take quite a while. "Oh I prefer to be an optimist. I think things are getting better. I don't pretend that things are easy. The recession is very difficult. There's the eurozone debt problems. That does not meant that we haven't actually managed to get through some of the tricky spaces. We [UK banks] have recapitalised well. There's a lot of that which doesn't show above the waterline, which is standing in a good state."
Angela Knight is a formidable operator, and it strikes me that life wouldn't be all that pleasant on the the wrong side of her. On the other hand, she is at least a fully paid up member of the human race, in contrast to the way some of her members appear. She's a good conversationalist. She laughs a lot. She doesn't take herself too seriously. When she talks about her children – one of whom is 24 and "trying to work out what to do" the other 22 and running a diving company for young people on gap years called "Dive the Gap" – she beams.
"I always wonder," she says in an aside, "when they were smaller whether I should have done it a different way. Life always happens around you, though. We do manage, the three of us [she is divorced], to have a proper holiday every year. We go skiing together. They're much better than me, but I'm quite fast, I just go straight down the run and find that when I've arrived I'm 30 seconds behind them."
Skiing at 60? This is a woman who seems to live her life at 100mph, with twice as much energy as many people half her age. Does she ever, though, get up in the morning and think, "I just don't want to do this"?
"Everyone feels that every now and again. But I put my make up on, I put my perfume on, and I say: 'Bugger the lot of them; I'm doing to do this.' Oh dear, don't say I said that.
"I certainly don't feel that I've run out of steam yet," she adds. Not by a long shot. The banking industry, at least, should be thankful.Reuse content


text: Greg Koch, the co-founder of respected craft brewer Stone Brewing Co., recently traveled through Ohio promoting his new book The Craft of Stone Brewing Co.: Liquid Lore, Epic Recipes and Unabashed Arrogance. He also took the time to chat with beer blogger Robert Massie in Cleveland; and James Knott, who runs the Better Beer Authority online talk show in Columbus. You can check out Massie's extensive Q&A by clicking here, and watch Knott's interview here.


text:
More Information:
|Spandex, Polyester
|Orange and White
|Wash care:
|Handwash, Machine Wash with Garment Bag
|Catalog No.:
My girlfriend ordered a pair of these leggings and we were both impressed by the softness of the material. They feel like quality leggings. However, they were too small for her and I would recommend buying a size up.
looks very cute but I think it's a bit too bright personally...
The fast-fashion brand 59 Seconds appeals to the sweet, carefree young woman with its colorful clothes and vivacious designs. Their affordable apparel mixes unique designs with popular styles to favor versatile mixing and matching. The bubbly coordinates focus on streamlined cuts that are perfect for happening Fridays and laidback Sundays. 59 Seconds is the youthful sister brand to business casual edition 59th Street. A YesStyle Exclusives brand, 59 Seconds features a unique selection handpicked by YesStyle's in-house Merchandising Team.


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Our Customers Say:
I have been a Travel Agency owner and operator for 20 years, and even though this was my first experience with Team One Tickets, I assure you, it won't be the last!
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Knickerbockers Seating Chart, Map and Tickets
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text:
Tropical Fish Keeping - Aquarium fish care and resources (http://www.tropicalfishkeeping.com/forum.php)
- Invertebrates (http://www.tropicalfishkeeping.com/invertebrates/)
- - Crawfish resource links (http://www.tropicalfishkeeping.com/invertebrates/crawfish-resource-links-2202/)
Crawfish resource links
I used to have 3 really good sites but my other comp crashed and now I can't find them again. Does anyone have links to where to get some of the more ornamental species? There was one that looks like it could be called a bumblebee craw and one that was almost a tranparent orange.
I'm sorry, but I don't know any.
This one, Chris?:)
That's one of them, the other one that was really good had a home page with a picture of a stream. Was a really cool site but I think the one you found has most of the ones I was looking for. :D
Yah, the cajun dwarf is simply awesome looking. And the Orange dwarf would be really cool also. Might have to think about setting up a tank some time this next year so I can get a couple and maybe breed them.
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text:
We maintain that a thorough and rigorous analysis of trafficking of EGFR ligands in polarized epithelial cells will continue to provide important insights into basic cell biology and the pathogenesis of colorectal cancer (CRC). The current grant cycle has been a period of significant productivity with 39 manuscripts and 4 reviews published that cite this grant. Simply stated, we intend to demonstrate that in the colon TGFA is beneficial and EREG is harmful. Endogenous TGFA acts to maintain colonic homeostasis;it stabilizes NKD2 to ensure its efficient delivery to the basolateral surface. After delivering TGFA to the basolateral surface, NKD2 binds and degrades DVL-1 (a positive regulator of Wnt signaling) so as to maintain tight regulation of canonical Wnt signaling. Loss of NKD2 is a frequent late event in CRC, and induction of NKD2 in Caco-2 cells initiates a program of goblet cell differentiation. Whereas TGFA mRNA is decreased in CRC, EREG expression is increased. Overexpression of EREG in colon cancer has been linked to metastasis. We show that tyrosine (Y)156 in the cytoplasmic tail of EREG regulates its basolateral trafficking and have identified multiple interacting partners. Remarkably, EREG(Y156A) is completely missorted to the apical surface of polarized MDCK cells, and the cells are morphologically and functionally transformed. We propose two aims to elucidate the divergent roles of TGFA and EREG in normal colon and CRC.
Aim 1. Test the hypothesis that NKD2 acts as a tumor suppressor. We will elucidate the mechanism by which induction of NKD2 in Caco-2 cells results in goblet cell differentiation. Using mice we recently generated, we will determine whether loss of NKD2 in Wnt-dependent (AOM) and Wnt-independent (Smad3-/-) colonic tumors results in more advanced tumors. We also propose to examine post-transcriptional regulation of NKD2 as part of a long-term therapeutic strategy to treat CRC by regulated re-expression of NKD2.
Aim 2. Identify factors (and their underlying mechanisms of action) that regulate EREG basolateral trafficking and signaling. Using wild-type EREG and EREG (Y156A), we propose to elucidate mechanisms underlying the invasive phenotype of apically redirected EREG. Finally, we will test the hypothesis that EREG is a "metastasis promoter" by attempting to prevent lung metastasis in a syngeneic mouse colon cancer model through elimination of EREG.
Through a detailed analysis of NKD2 as a potential tumor suppressor and the role of EREG in promoting metastasis, these studies will provide new insights into the pathogenesis of colorectal cancer (CRC) (and possibly other solid tumors). We expect that the results of these studies will guide approaches to enhance the expression of NKD2 as a potential therapeutic strategy and increase the efficacy of cetuximab in the treatment of patients with CRC.
|Poulin, Emily J; Powell, Anne E; Wang, Yang et al. (2014) Using a new Lrig1 reporter mouse to assess differences between two Lrig1 antibodies in the intestine. Stem Cell Res 13:422-30
|Li, Cunxi; Ma, Haiting; Wang, Yang et al. (2014) Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J Clin Invest 124:2172-87
|Singh, Bhuminder; Coffey, Robert J (2014) Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells. Annu Rev Physiol 76:275-300
|McKinley, Eliot T; Zhao, Ping; Coffey, Robert J et al. (2014) 3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer. PLoS One 9:e108193
|Singh, Bhuminder; Coffey, Robert J (2014) From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease. Semin Cell Dev Biol 28:12-21
|Powell, Anne E; Vlacich, Gregory; Zhao, Zhen-Yang et al. (2014) Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis. Am J Physiol Gastrointest Liver Physiol 307:G16-23
|Franklin, Jeffrey L; Rankin, Carl R; Levy, Shawn et al. (2013) Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA. Biochem Biophys Res Commun 440:99-104
|Washington, Mary Kay; Powell, Anne E; Sullivan, Ruth et al. (2013) Pathology of rodent models of intestinal cancer: progress report and recommendations. Gastroenterology 144:705-17
|Shifrin Jr, David A; Demory Beckler, Michelle; Coffey, Robert J et al. (2013) Extracellular vesicles: communication, coercion, and conditioning. Mol Biol Cell 24:1253-9
|Demory Beckler, Michelle; Higginbotham, James N; Franklin, Jeffrey L et al. (2013) Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics 12:343-55
Showing the most recent 10 out of 133 publications


text:
Tomlin Auto Service Ltd. Offers Auto Repair Services You Can Count On!
Since 1983, Tomlin Auto Service Ltd. has provided motorists in the Oshawa,
Ontario L1G 3R5 area with comprehensive auto repair services that include
General Services, Car & Truck Care, Inspections and Emissions, Undercar Services, Alignment, Brakes, Tires, Engine & Transmission, Engine Maintenance, Transmission Services, Heating and Cooling Services, Electrical Services, Electronic Services, Miscellaneous Services and Import Cars & Trucks. Our goal is to offer the best services available at affordable
prices to get you back on the road in no time.
VOLVO Vehicle Service: Tomlin Auto Service is founded on VOLVO maintenance and service. Our technicians offer 70 plus years of VOLVO maintenance and service.
BMW, VOLKSWAGEN, AUDI Vehicle Service: Tomlin Auto Service technicians have the knowledge, experience, and the equipment to service your BMW, Volkswagen & Audi.
Tomlin Auto services: North American, European, and Asian Vehicles as well as Light / Medium Duty Gas or Diesel Trucks
You'll be hard-pressed to find the same level of expertise that our auto mechanic specialists provide! We have years of experience working on both domestic and import vehicles of all makes and models and can work with you to find cost-effective repair and maintenance alternatives.
For a high-performing vehicle, trust Tomlin Auto Service Ltd. with your car, truck, or van. To learn more about the services we offer, please contact us by phone at 905-432-2305 or send us an email. We also invite you to learn more about our dedication to you, our valued customer.


text:
rolling stone
Rolling Sone found liable in UVA administrator defamation case
Rolling Stone, Wenner Media, and Sabrina Rubin Erdely have all been found liable.
Legal filings bring new details to light in Rolling Stone, UVA case
'By the time we ended our conversation, I felt nearly certain that she was not being truthful.'
Subject of retracted Rolling Stone UVA piece allegedly catfished a classmate
This story isn't going away.
Taylor Swift, Hillary Clinton, and the business of being 'liked'
Is Taylor Swift beefing with Katy Perry or is everything cool? I bet she hardly even knows anymore.
The problem with the petition to ban Kanye West from playing a Toronto event
Say whatever you want about Kanye West but you can't deny his talent.
What Rolling Stone can teach us about talking about campus rape
When I was raped in college, I felt I had nowhere to turn to. The fallout from the Rolling Stone UVA debacle can change that.


text:
Mal Meninga's first and only political press conference
Updated June 26, 2013 19:13:04
If you have inside knowledge of a topic in the news, contact the ABC.
This service may include material from Agence France-Presse (AFP), APTN, Reuters, AAP, CNN and the BBC World Service which is copyright and cannot be reproduced.
AEDT = Australian Eastern Daylight Savings Time which is 11 hours ahead of UTC (Greenwich Mean Time)


text:
Logo concept designed for an internal initiative at my last employer. The lightning bolt is a symbol we often used internally. The four 'sides' are representative of four departments.
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text:
Home Sweet Home Demo
by: IAmBaM • 12
All Android applications categories
All Android games categories
by: IAmBaM • 12
As you move around at home, your phone serves different needs as each room's purpose changes - recipes in the kitchen, card games in the familyroom, or music to help you sleep! Now, as you move from room to room at home, open the matching room in "Home Sweet Home" to easily launch the apps you frequently use in that room.
Home Sweet Home is a convenient app launcher utility based on the rooms of your home, but with a visual twist - each room in the app features an appropriate background image so you know which room you're in at glance. In each room, add and launch your favorite apps by opening the transparent sliding app panel. A list of your added apps is displayed so you can launch each with a quick tap, while command buttons at the bottom of the panel allow you to easily add and remove apps as needed; meanwhile, the background image remains visible so you know you're in the right room.
* User-friendly screen tap operation
* 7 rooms, setup each to match your needs
* Add & Launch Apps in each room
* Add & Open Web Links in each room
* Copy Bookmarks when adding Web Links
* Remove Apps and Links from each room
* Reorder Apps and Links in each room
* Export/Import of room App settings
* Help screen with full instructions
* Works on either phones or tablets
Available Rooms:
* Family Room (2 Entries max)
* Bedroom (2 Entries max)
* Kitchen (2 Entries max)
* Office (2 Entries max)
* Basement (2 Entries max)
* Garage (2 Entries max)
* Backyard (2 Entries max)
Requested Permissions:
Needed by export and import functionality
to access SD Card
Needed by "Add Web Link" functionality
to retrieve Web Browser Bookmarks
Planned Enhancements:
* Automatic sync with multiple devices
In case you decide to upgrade to "Home Sweet Home" or need to reinstall the app later, use the "Export" command to save your configured entries for each room to the SD Card. The exported data can be reloaded into either version of the app using the "Import" operation. Note: The export operation overwrites any previous export, and the import operation erases existing configured entries before loading the exported configuration.
If you are updating from an older version of the app, please note that Version 1.0.3 implements an improved method for querying and launching Installed Apps to address issues with the Contacts, Camera, and Gallery apps. Launch info for previously-added apps will be updated when you enter a room, but in rare cases an app may be removed instead - if this happens, just add the removed app back into your room using the Add an App command. This update also enables you to add the Phone app, which was not included in the Installed Apps list with the old method! (Update in Version 1.0.4 addresses an error reported by a user!)
Note: "Home Sweet Home Demo" is the free version of "Home Sweet Home" and is limited to adding 2 entries in each room. Please download the paid version to remove any limitations on all rooms.
If you experience any issues installing or using the app, please send us an email describing the problem in detail, and we will respond as quickly as possible.
Tags: free home sweet home games , sweetys home demo 1.0
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text:
The Carolina Consortium on Human Development (CCHD), based at the Center for Developmental Science (CDS) at the University of North Carolina at Chapel Hill, seeks to train productive researchers and creative scientists in an interdisciplinary program that is unique in its focus and breadth. This program is organized and administered across traditional institutional and discipline boundaries: the 95 members of the Mentor training faculty come from over 20 different academic units that are based at six cooperating universities and colleges (Duke University, Meredith College, North Carolina Central University, North Carolina State University, University of North Carolina at Greensboro, University of North Carolina at Chapel Hill). Such an arrangement permits the CCHD to bring together a strong and diverse group of scientists who share a commitment to the interdisciplinary study of developmental processes. Trainees come to our program from various backgrounds to become interdisciplinary developmental scientists. Unique training opportunities center around four basic aims: (1) exploring the theoretical and methodological foundations of developmental science;(2) providing direct experience in longitudinal research;(3) applying developmental science to real- world issues;and (4) facilitating collaborative training opportunities that extend beyond the usual boundaries of disciplines, departments, and institutions.
These aims are realized through (1) research opportunities with at least two different laboratories representing related but diverse approaches to issues of development;(2) weekly CCHD Proseminar meetings of our trainees and faculty with distinguished scholars on issues in developmental science;(3) workshops and symposia on targeted issues in developmental science;(4) collaborative research opportunities with Mentor faculty members;(5) experience with all aspects of longitudinal research, from conceptualization to publication;and (6) forums for discussing the application of developmental science to real-world issues. The program accepts postdoctoral Fellows for a 2-year fellowship and predoctoral Fellows for a 1-year fellowship. A vigorous recruitment effort is made to identify highly talented and motivated candidates from diverse disciplines and backgrounds. Predoctoral trainees must be registered in a doctoral program and have completed their basic departmental course requirements prior to entering the one-year predoctoral training program. Five postdoctoral and five predoctoral stipends are requested.
The Carolina Consortium on Human Development equips trainees to focus on basic issues concerning human development as well as questions of direct national concern about environments, programs, policies, and practices important for the wellbeing of our nation's children, youth, and families.
|Towe-Goodman, Nissa R; Franz, Lauren; Copeland, William et al. (2014) Perceived family impact of preschool anxiety disorders. J Am Acad Child Adolesc Psychiatry 53:437-46
|Towe-Goodman, Nissa R; Willoughby, Michael; Blair, Clancy et al. (2014) Fathers' sensitive parenting and the development of early executive functioning. J Fam Psychol 28:867-76
|Goldman-Mellor, Sidra J; Caspi, Avshalom; Harrington, Honalee et al. (2014) Suicide attempt in young people: a signal for long-term health care and social needs. JAMA Psychiatry 71:119-27
|Nelson, Eliza L; Campbell, Julie M; Michel, George F (2014) Early handedness in infancy predicts language ability in toddlers. Dev Psychol 50:809-14
|Gustafsson, Hanna C; Barnett, Melissa A; Towe-Goodman, Nissa R et al. (2014) Family Violence and Children's Behavior Problems: Independent Contributions of Intimate Partner and Child-Directed Physical Aggression. J Fam Violence 29:773-781
|Shadur, Julia; Hussong, Andrea (2014) Friendship Intimacy, Close Friend Drug Use, and Self-Medication in Adolescence. J Soc Pers Relat 31:997-1018
|Landor, Antoinette M; Simons, Leslie Gordon (2014) Why Virginity Pledges Succeed or Fail: The Moderating Effect of Religious Commitment Versus Religious Participation. J Child Fam Stud 26:1102-1113
|Elison, Jed T; Wolff, Jason J; Reznick, J Steven et al. (2014) Repetitive behavior in 12-month-olds later classified with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 53:1216-24
|Groh, Ashley M; Fearon, R Pasco; Bakermans-Kranenburg, Marian J et al. (2014) The significance of attachment security for children's social competence with peers: a meta-analytic study. Attach Hum Dev 16:103-36
|Swartz, Johnna R; Phan, K Luan; Angstadt, Mike et al. (2014) Altered activation of the rostral anterior cingulate cortex in the context of emotional face distractors in children and adolescents with anxiety disorders. Depress Anxiety 31:870-9
Showing the most recent 10 out of 52 publications


text:
Ariel Gallery
- [
Ariel Interview
"Portuguese Princess" Ariel
Real Name:
Ana Rocha
December 28, 1984
Originally from Azores, Portugal
Boston, Massachusetts
Marital Status:
Withheld at request of Ariel
Height & Weight:
5' 2" - 130lbs
Trained by:
Top Rope Promotions
Brickhouse Baker
Scott Ashworth
Jose Perez
May 12, 2001 (managing)
July 21, 2001 (wrestling)
Previous Names:
Sweetheart of Glory
Princess of ACW
Princess of La Familia
Arianna -masked- (Mexico)
Faith in Crush
"The Portuguese Princess"
Finishing Move:
Ariel Go Round (360 Spin Drop)
Dariel (modified Diamond Cutter)
Favorite Moves:
Modified Bulldog
Fisherwoman's Suplex
Notable Feuds:
Macaela Mercedes
Nikki Roxx
SSCW (Stars & Stripes Championship Wrestling) Women's title defeating The Crazy Mexican (December 29, 2001);
JWA Women's title winning an all-girl battle royal (October 26, 2002);
PCW Women's title;
Ace Wrestling Women's title;
BCW Women's title;
SCCW (South Coast Championship Wrestling) Women's title defeating Alicia and Tara Charisma (March 28 2003);
UWA Girl Tag Team titles w/Talia defeated Ref Hanson & Lady Lee (July 18, 2004);
IWA Mid-South/NWA Midwest Women's title defeating Mercedes Martinez and Hayley Skye (January 15, 2005);
PWF Mayhem Women's title defeating ????? ();
In The Beginning
May 12, 2001: Ariel debuted as the valet of Johnny Angel and took a vicious spear from wrestler Adam Booker..
July 21, 2001: Ariel (first match ever) defeated Amanda Storm, but not after taking a brutal beating!
Ariel once teamed with the Blue Meanie to defeat Steve Corino and Gino Giovanni..
December 29, 2001: Ariel defeated The Crazy Mexican for the SCCW Women's title..
October 26, 2002: Ariel won an all girl battle royal to become JWA Women's champion..
March 28 2003: Ariel defeated Alicia and Tara Charisma in a 3-WAY to become the 1st SSCW Women's champion..
June 14, 2003 - Ring of Honor: Carnage Crew (Loc & Devito) defeated Christopher Street Connection (Buff E & Mace) w/Ariel..
~~~After the match, the Carnage Crew did a brutal top rope spike piledriver on Ariel..
November 23, 2003 - Connecticut Championship Wrestling: Mercedes Martinez vs Ariel was a no contest when La Familia interfered..
June 12, 2004--Jersey All Pro Wrestling: April Hunter defeated Ariel..
June 19, 2004--USA Pro - Meltdown! 2: Ariel defeated Alere Little Feather & Cindy Rogers in a 3-WAY..
July 17, 2004 - ROH: Colt Cabana defeated The Christopher Street Connection in a "Handicap" match by pinning Ariel..
July 18, 2004 - UWA: Ariel & Talia defeated Ref Hanson & Lady Lee for UWA Girl Tag Titles..
August 13, 2004 - Defiant Pro Wrestling - From The Ashes: Ariel defeated Sumie Sakai..
August 29, 2004: Mercedes Martinez & Ariel defeated Sumie Sakai & April Hunter..
September 26, 2004 - CCW Metamorphosis: Cindy Rogers defeated Ariel..
December 11, 2004--New England Championship Wrestling: Hailey Skye won three-way over Violet Flame and Ariel..
Assault Championship Wrestling (Unsure of the actual dates for these results)
Next Level - Anger Rising: Mercedes Martinez deafeated Ariel..
Full Circle - Zero Tolerance: Riptide defeated Ariel, Mercedes Martinez and April Hunter in a Battle of the Babes match..
Total Impact- Riptide defeated Mercedes Martinez with Ariel as the special guest referee..
~~~After the match, Mercedes Martinez attacked Ariel..
November Pain - Balance of Power: Mercedes Martinez & Riptide & Ariel defeated The Ultimate Males..
~~~After the match, Ariel got beat up by her tag team partners..
Dark Offerings: Ariel & Jim Nastic defeated Mercedes Martinez & Riptide..
Fury Unleashed: Ariel & Trinity defeated Mercedes Martinez & Riptide..
Chains Unbound: Riptide defeated Ariel and Mercedes Martinez in a 3-WAY..
Evil Intent - Blood for Blood: Mercedes Martinez w/ Mike E. Milano defeated Ariel
Psychotic Breakdown: Ariel & Abunai defeated Nikki Roxx & D.C. Dillinger..
No Excuses: Ariel turned on Spider and joined La Familia!
January 15, 2005--NECW Snowbrawl: Ariel defeated Mercedes Martinez and Hayley Skye in a Triple Threat..
~~~Ariel captured the IWA Mid-South/NWA Midwest Women's title as a result of the victory..
February 12, 2005--IWA Mid South: Daizee Haze beat Cheerleader Melissa, Mickie Knuckles, Ariel, Sara Delray & MsChif..
~~~As a result, Daizee Haze captured the IWA Mid-South/NWA Midwest Women's title, which Ariel was the defending Champ..
March 4, 2005--PWF: Mercedes Martinez & Amber defeated Ariel & Demonica..
March 26, 2005--NWA Cyberspace: Ariel defeated Lacey..
April 15, 2005--Far North Wrestling: Ariel defeated Haily Hatred..
July 15, 2005--Ballpark Brawl IV: Ariel defeated April Hunter..
September 16, 2005--PWF: Ariel defeated Demonica..
November 6, 2005--Shimmer Women's Wrestling: Ariel defeated Rain..
~~~Later on in the show: Cheerleader Melissa & Tiana Ringer defeated Ariel & Shantelle Taylor..
January 21, 2006--NWA Cyberspace: ODB & Jazz & Cindy Rogers beat Aerial & Tracy Brooks & Talia in an Elimination match..
February 25, 2006--Conneticut Championship Wrestling: Ariel defeated Natalia by Submission..
March 5, 2006--New England Championship Wrestling: Ariel defeated Cindy Rogers to retain the PWF Mayhem Women's title..
March 10, 2006--Dangerous Women of Wrestling: Ariel defeated Della Morte...
May 6, 2006--NWA Cyberspace: Mercedes Martinez defeated Ariel . . . . .. .. .. .. . . . .
May 7, 2006--NECW/World Women's Wrestling: Mercedes Martinez & Nikki Roxx defeated Tanya Lee & Ariel ...
May 19, 2006--New England Championship Wrestling: Kristian Frost & Ariel defeated Zack Static & Nikki Roxx...
May 21, 2006--Shimmer Women's Wrestling: Malia Hosaka & Lexie Fyfe defeated Ariel & Josie......
~~~Amazing Kong & Lexie Fyfe & Malia Hosaka defeated Cindy Rogers & Ariel & Josie in a 6-Woman Tag..
June 4, 2006--NECW/World Womens Wrestling: Nikki Roxx/Brian Fury beat Scott Reed/Tanya Lee and Ariel/Kid Mikaze in a 3-WAY..
June 10, 2006--Defiant Pro Wrestling: Alere Little Feather defeated Ariel......
June 23, 2006--NECW: Frankie Arion & Evan Siks & Nikki Roxx defeated The Canadian Superstars & Ariel..
August 12, 2006--Defiant Pro Wrestling: Talia Madison won a Sole Survivor match to retain the Women's title ...
~~~Included: Lexus; Missy Sampson; Alere Little Feather; Cindy Rogers; Nikki Roxx; Ariel; Mercedes Martinez..
August 13, 2006--NECW: Nikki Roxx beat Ariel to unify the NECW & PWF Women's titles and become the 1st WWW Champion!
August 19, 2006--NECW: Nikki Roxx defeated Ariel by DQ in a 2/3 Falls match to retain the World Women's Wrestling title!
September 9, 2006--Defiant Pro Wrestling: Cindy Rogers defeated Ariel and Nikki Roxx in a 3-WAY by KOing Ariel..
September 10, 2006--World Women's Wrestling: Nikki Roxx beat Ariel and Tanya Lee in a 3-WAY to retain the WWW Title!
October 14, 2006--Northeast Wrestling: Nikki Roxx defeated Ariel in Milford, Pennsylvania ...
October 22, 2006--SHIMMER Volume #7: "Portuguese Princess" Ariel defeated Cindy Rogers..
October 22, 2006--SHIMMER Volume #8: Nattie Neidhart defeated "Portuguese Princess" Ariel with the Sharpshooter..
October 28, 2006--Ultimate Ring Wars: Amber & Kid Mikaze defeated Ariel & Jon Thornhill in a mixed tag match..
November 19, 2006--NECW/World Women's Wrestling: Natalia & Nikki Roxx vs Tanya Lee & Ariel in an Elimination match
~~~Natalia & Ariel were eliminated and Roxx put up her WWW Title.. Tanya Lee beat Nikki Roxx to win the WWW Title!
December 9, 2006--Northeast Wrestling: Ron Zombie & Nikki Roxx defeated Kurt Adonis & Ariel in Terryville, Connecticut..
December 10, 2006--NECW/World Women's Wrestling: WWW Champion Tanya Lee vs Ariel fought ended in a No Contest!
~~~Sean Gorman and Jana and Nikki Roxx interfered -- After the match, arch enemies Roxx and Ariel shook hands!
December 16, 2006--New York Wrestling Connection: Nikki Roxx defeated Ariel in a World Women's Wrestling match...
January 21, 2007--NECW/World Women's Wrestling: Ariel vs Portia Perez ended in a 15-minute time limit draw
~~~After the match: Portia Perez & Jana & Tanya Lee attacked Ariel until Nikki Roxx & Lexxus made the save!


text:
This soft and eco-friendly embroidered blanket is made from 100% recycled polyester.
Eco friendly promotional tote bag folds into small pouch for easy bring-along use.
ePromos is proud to present a great selection of environmentally friendly promotional items. Our eco-friendly promotional products collection features recycled, biodegradable and organic items as well as hand-powered electronics. If you are searching for an ecologically friendly promotional solution, look no further!


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Our Software Engineering services include web application design and development, e-commerce, life cycle support, database and data warehouse design, enterprise architecture design and support, and legacy migration services. Our developers create highly sophisticated applications based on the client's requirements.
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Our talent acquisition professionals are experts at finding the right candidate for your open position on a temporary, contract-to-hire and direct-hire basis.


text:
Collar Neck Dip Dyed Knit Sidetail Top - Indiaprice: contact company for price
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Delivery Detail: 15 days
Payment: : L/ C, T/ T.
Company Contact:
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Published date: November 19, 2014 -
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text:
© Copyright -
Request Information
Our Address
Plot 138
Lanseria Road R512
North West
Office: 083 286 8716
Share / Follow us
Give a gift of an exciting outdoor adventure experience for birthdays, bachelors, Christmas or whatever reason you can find to treat that special someone. Share the adventure with someone special! CLICK HERE
Specialising in Adventures & Activities in Hartbeespoort / Gauteng
Pelinduna Adventures offer the very best, affordable and most fun Adventure outings in the North West and Gauteng. We are proud of our services. The staff as well as our guides are trained to host each group with friendliness and professionalism.
We have what you are looking for. We host affordable functions and adventure activities like river rafting, quad biking, abseil, paintball and more. "No experience needed". Bachelor Parties, kids parties, year-
Adventure & Activities in Pelindaba
Welcome to Pelinduna Adventures
We are based in Broedertroom, a beautiful, small suburb at the foothills of the Magaliesberg Mountains in the North West Province of South Africa.
Not only do we boast with warm climates, abundant birdlife and venues with endless possibilities (situated on the scenic banks of the Crocodile River), but we are also conveniently found 40minutes from Jo'burg and Pretoria.
Whatever your level of experience and aspirations, our focus is to make your activity and adventure a pleasurable one and something you can share with all your friends and family.
Quad Biking
Experience the thrills and test your skills on exciting and interesting pathways, tracks and trails over rocky obstacles, water, mud, through bush veld scenes with beautiful views of the surrounding Harties area.
Experience the thrilling rush of abseiling (rappelling) down a vertical face. This is an exhilarating way to have fun, challenge your mates or an exciting way to build relationships with your work colleagues.
River Rafting
Whitewater rafting at Pelinduna is the real deal, real fun, real rapids real adventure on the Crocodile river. Come for the day or spend a weekend of outdoor excitement, treasuring this close-
Here are some exciting adventures you can choose from
We offer the following:
Feedback from our clients
Hi Pelinduna Adventures!
The guys had an excellent time and enjoyed it very much!
Thank you for all your assistance in making that day so special for our son!
Kind Regards
Ulrike Rutkowski
Our Location:
View map in larger window -
From N14 take the Lanseria offramp and turn right, Head towards Lanseria Airport on Malibongwe Drive (R512).
Drive past the traffic lite where you turn off toward Lanseria Airport and continue on the R512 passing landmarks such as Home of the Chicken Pie, Lesedi Cultural Village (on the left which is 2km from our headquarters) until you see Nikita Motel on your right.
You'll see a BLUE KAYAK (boat) on a POLE behind a huge banner with our name and the Restaurants name (Our House) on it, turn right and drive a few meters down the dirt road until you see our gate (first gate) on your left.
GPS: Lat 25.8241 S. Long 27.8926 E
"The purpose of life is to live it, to taste experience to the utmost, to reach out eagerly and without fear for newer and richer experience."
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Clientele Life Assurance: Hi Guys. Just a word of thanks from our side for hosting us last week Friday for our team session. We really enjoyed the day and the food was excellent too.
Best Regards
Thank you so much for a perfect Saturday morning. Best experience ever…had so much fun
Baie dankie vir alles. Thank you.
Thabang Lelaka
My groep ouens het 'n uitstekende tyd gehad en jou ouens was great en baie accommodating (ons was bietjie laat gewees). So ek se baie dankie vir 'n great experience!
Eben Engelbrecht
083 286 8716
OR Email us: firstname.lastname@example.com
Why not make a day of it?
Choose one of our Adventurous outdoor combo packages. Please note – Different venues might be used for certain combos. In some cases a 5-


text:
The descriptions of the protests in Syria seem conflicting, pertaining both to the demeanor of the demonstrators, the reaction of the Syrian Government, and in particular, the steps taken by Syrian Police. Available information describes a "sit-in" demonstration in Douma, near Damascus. A sit in for democracy is the least aggressive of any of the varieties of new wave protests for demands by students in Northern Africa, and Near Eastern nations. The police we are told cut off electricity to the area, at about midnight and activists speaking anonymously say the protestors were attacked. Some 200 were arrested, then released the following morning, those allowed to go having submitted a request for release, in writing. It is unclear whether they were required to confess to some guilt. Other reports place the number released at about 70.
It was further reported that a number of Islamic prisoners at the Saysnaya jail were simultaneously early-released, to placate the rising level of protest. Under law, these men were qualified for release, but that release hadn't come.
With the advent of the internet, and modern 'social' communication, students and others who had accepted various levels of repression are now seeking to be free. The world is changing at so quick a pace, regimes find difficulty keeping up. A free society is less Deist, more secular. For thousands of years, a rule of law/religion based on the will of the Creator, or an interpretation of the will of the Creator has been the standard in many ancient areas. Americans, and those in the West, familiar only with secular rule, "under God", are often shocked and revolted by what in ancient areas is commonplace; checking of the virginity of maidens is a current example. Death by stoning, not mentioned in the Qur'an, but common until recently under Sharia, Islamic law, is another example. Lately these ancient ways have been modified and are more constrained.
Global culture extends by any definition over many thousands of years; years of trial and error. Civilizations rise and fall. We humans often don't understand the wide range of variables that exist in governments. When governments are family run, over generations, the chaos caused by the infusion of new ideas is mightily exacerbated.
Available reports are conflicting. Unverified claims indicate that dozens of protestors at the demonstration in Douma were killed by Syrian Police. These claims are substantiated by witnesses, and are taken seriously by the United Nations, and the United States.
On the day following these killings, Saturday, March 26, in Syria, thousands of mourners were attending the funeral, or watching the funeral procession of Kamal Baradan, one of the protestors. The funeral of Kamal Baradan was not in Damascus, rather in the village of Tafas, near the town of Daraa. We surmise he must have traveled for the initial protest. Baradan's funeral turned into a riot in Tafas, as those present burned the local Baath Party headquarters and a police station. Three of the mourners, bare chested, carried signs demanding the downfall of the Syrian regime and climbed the decaying statue of late President Hafez al-Assad.
Viewers to televised and printed media are aware that protests in Syria have escalated considerably just in the past hours. The world will continue to change; regimes will react or fail to react. Morality at this difficult age is for each of us to determine.Powered by Sidelines


text: Laidback Luke, Arno Cost and Norman Doray - Trilogy (GTA Big Room Mix) by Mixmash Records published on 2012-02-28T11:51:32Z Since the release of "Trilogy" the track is buzzing its way to the top in EDM land. It climbed up to #11 in the Beatport Main Chart and is supported by some of the biggest DJ's around. Now we proudly present you "The Remixes" of this already legendary tune! First in the package is the Russian trio Swanky Tunes who are turning heads since they delivered their amazing track "Across The Light" and "Together to us and now traveling the world with their Big Room sounds! Like always they managed to turn the original track into something Big! Hailing from Sweden is this up and coming dj/producer Sebjak who already has some big releases and remixes under his belt. Seb took this track a bit to the tech-house side of things with some nice rolling beats. Next up are our friends GTA from Miami who are surprising us each and every time with their refreshing sound. Last time they treated us with some Dubstep and now delivered a Big Room monster! Last but not least are Dutchies Sam O Neall & C6. Both already delivered some amazing remixes for our tracks "Across The Light" and "Turbulence" and now turning "Trilogy" into a dancefloor bomb! Hit the play button now and stay tuned for the official release on the 8th of March at Beatport! Genre Big Room Comment by drops ⛈ OH . MY . GAWD . 2015/09/04 03:43:36 +0000 Comment by Luan Awfulitch @seanjohnsonofficial: TOP 2012/10/02 16:04:20 +0000 Comment by No_way Good ! 2012/06/18 21:23:04 +0000 Comment by RK. amazing 2012/04/24 11:49:59 +0000 Comment by Top Harvest Mixes please check this track out: http://snd.sc/ww3ouv 2012/03/18 20:50:27 +0000 Comment by tracksoftheday SPREAD !!! http://soundcloud.com/ricowkalio/ricow-kalio-rescue 2012/03/13 06:13:33 +0000 Comment by tracksoftheday @mslink531: SPREAD !!! http://soundcloud.com/ricowkalio/ricow-kalio-rescue 2012/03/13 06:13:30 +0000 Comment by tracksoftheday @nspireproject: SPREAD !!! http://soundcloud.com/ricowkalio/ricow-kalio-rescue 2012/03/13 06:13:28 +0000 Comment by tracksoftheday @avallo: SPREAD !!! http://soundcloud.com/ricowkalio/ricow-kalio-rescue 2012/03/13 06:13:23 +0000 Comment by tracksoftheday @dj-gox: SPREAD !!! http://soundcloud.com/ricowkalio/ricow-kalio-rescue 2012/03/13 06:13:19 +0000 Comment by tracksoftheday @frankox: SPREAD !!! http://soundcloud.com/ricowkalio/ricow-kalio-rescue 2012/03/13 06:13:14 +0000 Comment by tracksoftheday SPREAD !!! http://soundcloud.com/ricowkalio/ricow-kalio-rescue 2012/03/13 06:13:10 +0000 Comment by Top Harvest Mixes amazing 2012/03/09 14:04:06 +0000 Comment by baztian4 really amazing! can you guys check out my tracks? http://soundcloud.com/baztian4 2012/03/02 19:03:20 +0000 Comment by Raymon V JJIIZZZZZZZZZZ 2012/03/02 10:14:48 +0000 Comment by Melfrez the best remix! 2012/03/01 21:57:05 +0000 Comment by makosumas fantastic!! 2012/03/01 18:22:04 +0000 Comment by DJ_Wish Nice! 2012/03/01 18:12:11 +0000 Comment by Djuro YES! 2012/03/01 00:21:54 +0000 Comment by Secret Ingredient best remix yet! 2012/02/29 20:03:45 +0000 Comment by seanojohnson kinda like electro disco house or some shit. love it 2012/02/29 08:25:39 +0000 Comment by body_snatchers very large 2012/02/28 18:55:04 +0000 Comment by No Saints fade into darkness (albin myers remix)? 2012/02/28 18:48:16 +0000 Comment by Budapest Bonkers Posted on BPB: http://budapestbonkers.blogspot.com/2012/02/laidback-luke-arno-cost-norman-doray.html 2012/02/28 18:47:56 +0000 Comment by ajcblanco this beats all the other remixes :D 2012/02/28 18:31:51 +0000 Comment by ajcblanco yessssss 2012/02/28 18:28:43 +0000 Comment by Nspire Project Blogged and supported at http://i-love-edm.blogspot.com/ 2012/02/28 16:52:52 +0000 Comment by Robertt__ i like :) 2012/02/28 16:49:56 +0000 Comment by Robertt__ coooool 2012/02/28 16:49:49 +0000 Comment by J4ck On D3ck cool tune !!! 2012/02/28 16:38:45 +0000


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Item #02034
Product Description
Place our Pub Bar Table anywhere you need extra counter space. The clean lines of this versatile piece offer universal style. Available in your choice of distressed finish, this table offers plenty of room for casual meals, working on projects, displaying collectibles and more.
Product Details
Holbrook Dining Table
Hand-Carved Franklin Hall/Dining Table
Martha Stewart Living Craft Space Table
$259.00 - $269.00
Edmund Dining Table


text:
Forum Posts, Moderating, Reporting, etc. 12/20/2016The Report function of the forum works well. If you see someone acting up, acting out, or just being an okole, use the Report function. It works! I have it set up so it not only sends me an email, but that email is then marked with a flag, and get's put to the top of my email list. I will try to access/look at the report/topic as soon as possible, but remember, I'm on a six hour time delay, and other mods not only have a life, but a real job as well. k den
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dwc43 added a post in a topic Wanted. 94-01 dodge RAM extended cab.There is a 94 long bed and a 96 dually snap kit, made by AMT. Only ones I know of. Hope that helps.
dwc43 added a post in a topic Fuzz Duster - Innards are done!I thought it looked pretty good to me. I own one of these Road Runners low mileage original show winning car. Only thing you got wrong in the writing portion is that these cars also came with the 360. And these cars were faster than the same year vette. Only thing that could outrun these trucks was the Little Red Express trucks cause they did not have the emissions to deal with. Not cat converters air pumps or anything like that. It's not your fault either, but the kit got the drivers side exh. manifold all wrong too. It's up swept like the old 70's 340 piece that went on the Duster.
dwc43 added a post in a topic AMT Sunbeam Tiger motorBlueprinter. That's what it was called. I found Sunbeam Tiger Blue Printer on e bay. I knew if I searched for it I'd find the correct name. lol
dwc43 added a post in a topic AMT Sunbeam Tiger motorI've got one half built stored somewhere in a box. It had both engines. And fender flares and race parts and stock steel wheels and racing wheels in it. It came in a plain white box with black ink. I think it was an amt/ertl box. It was some kind of signature series or something special like that. I cant remember what was on the box now. I got it off e bay a few years ago. I was going to build a race car out of it, but the engine sit in it funny. Never could get it to lay in there flat like it should. I figure if I get back to it, it's going to get the 4 put in it and I'm going to do the Get Smart car out of it. It's not signature series either, someone on here will see it and know what I'm talking about.
dwc43 added a post in a topic AMT Sunbeam Tiger motorIt also comes with a stock 4cyl. too. Which one do you need?
dwc43 added a post in a topic Pittsburgh PA police decalsCheck here. http://www.policecarmodels.com/
dwc43 added a post in a topic 1980's Pro Stock Cars...Magneto or Distributor?Distributors with msd boxes.
dwc43 added a post in a topic Johnny Cash "One Piece at a Time" CadillacI saw that black Caddy when it used to sit outside in front of Johnny's house when I was a kid. There was no walls or gates or anything. My dad drive up in this circular drive and we looked but did not get out of the car. It was parked in the grass beside the drive in his front lawn.
dwc43 added a post in a topic Speedway Replicas Buddy Arrington decalSweet!!!
dwc43 added a post in a topic greetings, boils and ghoulsJim16 has parts you need on ebay for your car.
dwc43 added a post in a topic Plum crazy purple with what interior colorPlumb Crazy cars only had black interior from all the real cars I have seen and dealt with. Even my Moms Demon had black interior with PCP color. That's not PCP by the way. PCP is not metallic like yours.
dwc43 added a post in a topic 1962 Dodge Darthttp://www.ebay.com/itm/VINTAGE-JOHAN-1962-DODGE-DART-CONVERTIBLE-BUILT-/371567317136?hash=item5683235090:g:l1AAAOSwvgdW2Yfc
dwc43 added a post in a topic Duster Dog Dishes
Rosco's police car has the dog dishes. Same cop car from T.J. Hooker and goon car from Batman. Wheels are right, but too wide. Several aftermarkets make the steel wheels.
dwc43 added a post in a topic 1973 plymouth roadrunnerThe Bee chassis works better due to how the firewall and fender wells are made on the Bee compared to the Charger. I already have one under the same car being built here, but it's just a mock up for now. I'll get to it in the future, I hope. lol
dwc43 added a post in a topic Piedmont Olds
I have to agree with you there on both points.


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OTO Project
This project received 8 bids from talented freelancers with an average bid price of $1148 USD.Get free quotes for a project like this
Project Budget$750 - $1500 USD
Total Bids8
Project Description
To build a unique oto plugin with short codes find attached the wireframes for this software this explains in detail what is needed from the plugin
Skills Required
Looking to make some money?
- Set your budget and the timeframe
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- Audience: Children aged 13-17. This activity can be done in a classroom, an after-school program, or at a community youth center.
- Students can better understand the possible effects of different land-use and water-use policy scenarios on ecosystem services and biodiversity.
What's the commitment?
- 2 hours to prepare materials, coordinate with a school, and identify a local expert in water management
- 90 minutes for the presentation and activity
- If a field trip to a nature preserve is included, this becomes a half-day activity.
Activity resources
- Activity presentation
- Volunteer guide to the team activity
- Creek Watch is a project developed at the IBM Almaden Research lab, in consultation with the California State Water Resources Control Board. You can download a free iPhone application that enables you to help monitor the health of your local watershed. Free iPhone application
- Frequently Asked Questions about Activity Kits for volunteers


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