text:
Blueberry Syrup
|1 Pint
|2 Cup (32 tbs)
|Cinnamon stick
|Lemon juice
|2 Tablespoon
Combine blueberries, sugar, cinnamon, and cloves in pan with 1 1/2 cups water.
Bring mixture to a boil and boil for 10 minutes or until lightly thickened.
Strain, stir in lemon juice, and pour into sterilized jars.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1837 Calories from Fat 14
% Daily Value*
Total Fat 2 g2.5%
Saturated Fat 0.14 g0.71%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 10.9 mg0.5%
Total Carbohydrates 474 g158.1%
Dietary Fiber 13 g52.1%
Sugars 448.2 g
Protein 4 g7.9%
Vitamin A 5.4% Vitamin C 101.9%
Calcium 5.8% Iron 9.1%
*Based on a 2000 Calorie diet


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In this issue, you'll find our report from ALIS (Americas Lodging Investment Summit), which was held at the end of last month in Los Angeles. In fact, many of you were probably among the 3,000 industry professionals there. The theme of ALIS 2017? "Please Stand By." But many industry leaders are choosing just the opposite and instead of staying static, are moving ahead with plans and projects—and forward-thinking initiatives.
Ascent Hospitality Acquires Marriott in Huntsville, AL »
Hyatt Launches "For a World of Understanding" Campaign
FelCor Offers Clarification on Ashford Acquisition Proposal
Former French President Sarkozy Joins AccorHotels' Board
Wynn Resorts Names Craig S. Billings as CFO
Outrigger Positions Itself for Future Growth
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subset: commoncrawl


text:
Meaty Vegetable Soup
|Bean soup mix
|1 Cup (16 tbs)
|Smoked pork hocks/Beef shank crosscuts
|1 Pound
|Canned tomatoes
|16 Ounce, cut up
|1 Medium, chopped
Prepare Choose a Bean Soup Mix as directed through the soaking step.
To the soaked bean mixture add smoked pork hocks or beef shank crosscuts.
Bring to boiling; reduce heat.
Cover and simmer 1 hour for pork hocks or 1 1/2 hours for beef shank crosscuts.
Remove meat from pan.
When cool enough to handle, remove meat from bones and coarsely chop.
Discard bones.
Remove and discard bay leaf.
Return the chopped meat to pan.
Add undrained tomatoes and carrot.
Cover and simmer for 30 minutes more.
Season to taste with salt.
Ladle the soup into soup bowls.
If desired, tie a bone and bay leaves together for a garnish.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1484 Calories from Fat 889
% Daily Value*
Total Fat 99 g152.1%
Saturated Fat 28.2 g141%
Trans Fat 0 g
Cholesterol 220 mg73.3%
Sodium 1112.2 mg46.3%
Total Carbohydrates 72 g24%
Dietary Fiber 13.7 g54.9%
Sugars 9.7 g
Protein 80 g160%
Vitamin A 267.2% Vitamin C 75.6%
Calcium 17.4% Iron 33.8%
*Based on a 2000 Calorie diet


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Williamsburg Dinner Theatre
• A WorldWeb.com Travel Guide to Dinner Theatre in Williamsburg, VA, Virginia.
Located near Historic Colonial Williamsburg, this dinner theatre features a hilarious mystery/comedy skit being performed for & with guests. Audience participation, Great Food & Drink will make this a Fun, Engaging, and Memorable Night. Hosted in the Quality Inn and Suites Banquet hall Every Friday Night. Toll Free: 1-844-8MY-SHOW
Enter the theatre in the Quality Inn Historic and become a patron of the 16th-century English pub, where guests are encouraged to bang tables, sing along, and become part of the show.
Be apart of the show as you try to solve a comedy mystery. In between acts enjoy a delicious four course meal. The actors serve your meal giving you the opportunity to "bribe" them for more clues. At the end of the night we collect your answers. Correct answers will be eligible for a prize! The Mystery Dinner of Williamsburg is perfect for birthdays, anniversaries, graduations, date night, school groups, or whatever else you can think of! You'll die laughing!


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Introductory Algebra
Miller, Charles D.; Lial, Margaret L.
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Title: Introductory Algebra
Publisher: Scott Foresman & Co ,U.S.
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The relationship between cholesterol and exercise is an interesting one. Most researchers are still unsure how cholesterol is lowered by physical activity, but they are beginning to understand a little more.
We do know that exercise helps people to lose weight, or to maintain a healthy body weight, which can help reduce the low-density lipoprotein (LDL) in our bloodstream. This has long been associated with heart disease.
The confusion around exercise's impact has come because many pieces of cholesterol research combined exercise and dietary changes, which made it difficult to know exactly what brought about any reduction. In recent times we have seen more research focusing on exercise exclusively, which has provided a clearer picture.
Previously, there was a lot of debate surrounding how much exercise was needed to see a reduction of cholesterol. Most public health organisations around the world recommend a minimum of 150 minutes of moderate-intensity activity each week.
However, more recent research has suggested that more intensive exercise is more efficient as it can also help to lift the high-density lipoprotein (HDL), or "good" cholesterol, as well as lower LDL cholesterol. This means intensive exercise offers a double boost in helping manage cholesterol.
How much can exercise help?
In most cases, this depends on the circumstances of the individual. People who had a poor diet and didn't take part in much exercise were more likely to see bigger results than those who had a healthier lifestyle. On the more unhealthy people, they can see LDL reduced by 10% to 15%, and HDL increased by around a fifth.
Sounds good - how do I get started?
If you don't exercise much at the moment, you should make sure you start slowly - these guidelines should help you stay healthy:
• Try to find a form of exercise you can do for 10-20 minutes at a time at least to a moderate level of intensity. This could be walking, jogging, swimming, cycling or many more activities
• For best results, be aware that while the activity may be moderate, exercising for longer periods of time (your exercise volume) is helpful
• Choose something you enjoy as this will help keep you motivated. This could be anything from taking up a sport to walking the dog. Exercising with friends and family may help keep you motivated too
• If you can, take up several activities. This can help you exercise different muscles in your body, while the variety is also useful for motivation.
It is important to recognise that exercise alone won't guarantee your cholesterol level will reduce. There are many factors which can influence it, including your weight, diet and even your smoking status.
However, even if the changes to your cholesterol through exercise are quite small, you'll feel many other benefits by getting out and about. These include more energy and a better mood, while you can also reduce your risk of many illnesses and diseases, such as diabetes (type 1 and type 2), stroke and some cancers.


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text:
Never Enough
By Angelfirenze
Disclaimer: Whedon owns all. Fall Out Boy. "I Don't Care.". Folie à Deux, 2009.
Summary: Angel didn't let on that this was in the previous century. There was no point.
Notes: This one got put on the back-burner by my muse for a bit. It seems to be back for the time being.
Notes, cont'd: The Magdalene Asylums were initially refuges to assist and rehabilitate women, particularly in Ireland, but also in other countries including the United States, who had engaged in prostitution or suffered sexual abuse of any kind.
They increasingly turned into punitive sorts of prisons where 'fallen' women who had borne children out of wedlock through means of 'indiscretion' or rape were forced to do hard labor, most often laundry for long hours and never allowed to see any children who resulted from their 'affairs'. The last Lady Magdalene laundry closed in the Republic of Ireland in 1996.
Mal leaned irritably up against the counter as he watched Doctor Tam examine both River and Connor in their sleep. He glared at Angel again, once more bothered when he didn't get much of a response from the apparently ancient man.
"You know," he said irritably, unaccountably disturbed as he watched Angel lean over and stroke Connor's hair away from his brow before kissing it. "As much of an explanation as you pretended to give us about your boys there, you really didn't and it's startin' to get on my nerves. Doc explained about his sister - you said my ship was honest and as long as you're on it, that'll include you and I don't care how old you are, dong ma?"
"I do keep dancing around it, don't I?" Angel asked lightly, thoroughly dismissing Mal's attempt to threaten him and, thus, angering the captain further, which Angel noticed, though his face remained contemplative.
"Point: Sam is a vampire with his soul returned to him - I arranged for that before Los Angeles fell so it was still in place when Hell on Earth That Was came to our doors and when the door was slammed shut. It - Sam's soul - remains there to this day.
"Point: Connor is my biological son who shouldn't be alive except that God - you'll leave me to my beliefs, captain, and I'll leave you to yours. Yes, his mother was another vampire - my sire - ah, the vampire who made me...a vampire. Darla.
"She and I had an interesting talk about that that's...actually probably not very interesting to anyone but Shepherd Book, but...she damned me, just as surely as she'd damned herself. But...she gave her life for our son. Connor. She died to save his life the night he was born."
Mal, on the point of interrupting, snapped his mouth shut, a glare on his face and his heart thudding for reasons he honestly didn't understand. Angel had made it a point to seem as non-threatening as possible to him and his, so what the hell was up all of a sudden that he couldn't get a word in on his own ship, nor assert his own rules without being brought low and Angel was doing it again and again and all he felt about it was a schoolboy's gorram shame? That didn't damned well make sense.
He avoided looking at Kaylee's face right now, knowing her feelings almost as well as he knew Zoe's. She would be heartbroken to hear Connor's origins and wouldn't bother hiding it none.
But Angel was talking again and Mal found himself strangely compelled to listen, " - God wouldn't waste a promise made in earnest. I earned a life so when his mother couldn't use it, it was given to him. He's human except for demonic strength, healing, reflexes - apparently he can't age past sixteen, either, though being in the Quor'Toth dimension poisoned his body so much that now that he's out of that cesspool, his mind has taken up the slack, though I doubt it would have again if the Alliance hadn't gotten a hold of him."
Angel sighed very heavily and Mal and Simon could both feel over a thousand years of weight within that soft expulsion of air, but Mal fought not to let it affect him.
"I can feel everything that's been done to them, I just don't know what it was. My body is non-specific about anything other than them hurting. And Connor and Sam hurting, I cannot abide peacefully or no."
Angel had gotten a haircut on Persephone and now ran his hands through his once-again short hair, feeling as though he did when he first reached the shores of New York so long ago. He had to find his ground, now, and try to stand on it.
"Point: Sam was already suffering even before his soul was returned - I...my soul...when I turned him, I had my soul, so a fragment of it was given to him. We share souls just like my youngest does with his mother...when she was pregnant with him, his soul suffused her, gave her a conscience she didn't have otherwise. But Sam..."
Angel ran his hand over his hair again and frowned, remembering that day as clearly as any other, just like always. "He...Sammy begged me for a mission - to kill him, but I couldn't...I couldn't keep the promise I'd made sixty years before - so I decided to use Wolfram and Hart's - I know those words mean nothing to you - resources to pull his soul out of the ether and give it back to him."
Angel's face became forlorn but resolute, "I damned myself again - or so I thought - because I played God just as the Romany gypsies - ancient tribe, long gone - no point in explaining now - who cursed me did, except that my intent wasn't that of revenge, but of salvation. Perhaps that's why he's never lost it."
Angel sighed, "I took him to see a friend of my mate's - my wife, she's dead, I don't want to talk about it - and he was able to tell me that Sam's soul is not in the precarious position the gypsies left mine in because I never wanted him to suffer. The same actually went for me by then, and I was surprised that he told me that because he hated me, except that my mate and another of our friends - the one who restored mine the second time - threatened him with certain torture if he didn't tell the truth that time."
Angel didn't let on that this was in the previous century. There was no point.
"The innocence in Connor's soul was destroyed by the man who raised him instead of me. Then, further by the...thing...whose face your first mate and best friend resembles through no fault of hers. Connor put his fist through her skull and then tried to kill himself and twelve other people after taking them hostage."
Angel continued to stroke Connor's hair, never once looking in the captain or Simon's directions, even as he knew he caught Simon up short. "I did it for him and then I had his memories and past rewritten. This was undone later by my best friend, Wes, who made a presumption based on my mistaken belief that what they didn't know couldn't hurt them - I have a long track record with that, hence my words earlier about the truth and my adherence to it now.
"Still, hopefully, I can bring him back to where he was on Earth That Was, after all of that. My best friend - not him, her name was Cordelia - was able to detox him of all the horrors of that place, but another of my best friends - the one I was just talking about - accidentally opened them all back up again out of a mistake."
Angel frowned now, infinitely saddened, "Sometimes Connor's able to escape them, others he thinks he's back there - killing because it kept him alive. The demons in that place called him 'The Destroyer' and that's who he becomes. That's who you saw when he was up on that scaffold.
"Right now - and just as soon as he landed down in front of River and they communicated, sharing each other's sorrows - he's asleep. He's just Connor. I-I need to go get his hockey jersey. He likes to sleep in it and Willow - she put a spell on it so it would never fall apart..."
Angel carefully turned toward the exit, but Mal got in his way. He sighed and forced himself to be patient.
"Yeah?" Mal challenged, visually fed up with Angel's adept ability to set up camp under his skin and bother the go se out of him like a damned tick. Angel would have smiled if he didn't feel like crying all the time now. "Well, you still haven't answered what the hell you are - "
Angel turned around and opened his mouth, but Mal cut him off. "Yeah, you listed all kinds of titles, but you never said WHAT. YOU. ARE."
Angel's calm demeanor still failed to change and Mal felt himself growing yet angrier, until he - fed up - snarled, "Soon as we stop on Whitefall, you and yours are gettin' the hell off my ship."
"I paid your mechanic fare for myself and my sons for however long we want to stay on this ship. Unless you give us that money back, we're not going anywhere." Angel's tone, in turn, while still calm, didn't allow for discussion. "And even if you do, I doubt either of them would go without my say so and, even then, not without a fight - which I don't want and I know my youngest doesn't want."
Trevor Lockley's only words to him came back yet again, as they often did these last five hundred and some odd years and now he repeated them to Mal, his voice quiet and wistful.
"You got any kids, Mal?"
Mal obviously resisted the urge to roll his eyes, "I assure you, Angel, if I had any runnin' around the ship, you'd never miss 'em."
Angel took this in, expecting as much, "Then don't try to tell me how a father feels or why he does the things he does. A loving, if misguided man told me that once. I didn't have any children at the time, myself, and said as much. I didn't understand desperation until I looked in my son's eyes and tried to convince him he had things to live for, that he had family and friends who loved him - that his life had only just started, but he was right. I just wasn't there before. I missed sixteen years of his life - his first steps and words, his - well, I suppose this only would have mattered since he was my son - his first kill. I couldn't comfort him or reassure him.
"I highly doubt the son of a bitch who raised him ever did much of either, no matter what he said. I know it felt foreign to him as it had to me at his age. Different circumstances but the result was the same - he just wanted to stop fighting. Stop feeling alone. I didn't understand horror until my other son had my best friends trussed up with double-aught wire, gagged and helpless, his eyes looking into mine - Come on, chief...
"Don't underestimate me, captain, I picked your ship for a reason, and it may be yours, but you won't be the one who gets us off it."
Angel frowned further and wheeled around, followed by both Simon's exclamation of shock and Mal's loud swearing.
Sam was leaning in the door jamb, his boyish grin on his face full of pain that Angel easily recognized from the moment Sam had been Sired.
"It gets funnier every time you tell it, Chief. I always wonder if I'll stop being amused, but - every damned time."
"Sam," Angel said quietly, adopting the same mildly chastising expression he'd held earlier toward Connor. "Did you hurt anyone here?"
"You already know I didn't, Chief," Sam said easily, entering the infirmary and ignoring the flinching Simon did toward both the sleeping River and Kaylee, as well as the captain's reflexive pull and cocking of hs gun. Sam looked at the gun and chuckled lightly, looking at his father and pointedly rolling his eyes.
"You know my rules, Sam," Angel reaffirmed and Sam sighed and shook his head 'yes'. "Will you sit very still and let the doctor examine you - "
Both ignored Simon's deer-in-headlights expression. "Or will I have to hold you down and gag you?"
"The brig, again? But, sir, I was just released! I haven't gone against regulation!"
Angel sighed, "It's not that you've done anything, son, it's - "
"She looks ripe," Sam said idly, his placid face on Kaylee and the captain swore again, stepping in front of his mei mei and pointing his gun directly at Sam's head. "Oh, that won't do...well, it'll make a terrible mess - I'll suffer amnesia and definitely migraines from hell, but eventually I'll be to rights."
"Samuel Aaron Lawson Angel," Angel said dangerously and, surprisingly, Sam froze, whimpering.
"Not right - not right..." Sam muttered, tears suddenly springing to his eyes and spilling over. It was only then that he got a look at River and his eyes widened. He slowly looked at Angel. "Chief?"
"Are you going to be good or do I have to put you in the brig again?"
"No...no, no - no, please?" Sam whispered, biting his lip, drawing blood, which slid down his face. Angel calmly swiped it away with his thumb, licking it off before taking hold of Sam's face and gently holding his attention.
"Are you going to let the doctor look you over and make sure the - "
"Hands of Blue, two by two, Hands - "
River stirred worriedly against the wall, her murmurs becoming the same as Sam's, "...Of Blue...Two by Two..."
"No, not that kind of doctor, Sammy, I promise. He won't poke and prod. He just fixes things gone wrong with your body - puts things back to rights. Gets everyone through this..."
"Safe and sound," Sam said softly, a relieved breath coming to him as River muttered, "Safe and sound" in a small echo and finally settled.
"Is he your first in command, sir?" Sam asked worriedly and Angel frowned, openly bothered.
"Of course not, son. You and Connor. Always. I know I promised."
"You did, very, very long ago. The world was fire and demons were in the ground and the sky and of the buildings."
"Everything was hell, I know. I...messed up again."
"No!" Sam disagreed fervently, reaching forward and gripping every inch of Angel's torso that he could reach. Angel picked him up effortlessly and placed Sam on a table. "You didn't!"
"Well, who else did? Who got Wesley killed? Who got Gunn - "
"Turned back into a man in more than just flesh. You gave of yourself. Little Brother was dead - you made them turn you back into this, into us...if not quite."
Angel was stripping Sam of his clothing and Simon was gripping his medkit as though his life depended on it, but - and this Mal noticed, as well - hadn't begun inching away from the bed. Kaylee was now awake and watched with wide eyes, but didn't seem to be horrified. Afraid, yes, but not terrified. Angel knew she saw Sam as the victim he was, so many times over.
"Which he has been," Angel said softly, glancing at her, long used to the way her eyes now widened because he knew her thoughts.
"You a reader?" Mal asked, aiming his gun at Angel again, who rolled his eyes and sighed, "Did I not say that? Did I not say I have the ability to see things that are coming and, if they're strong enough, other people's thoughts? And that I can influence the thoughts, emotions, and actions of my sons?"
"You...did..." Simon said hesitantly, afraid to look away from Sam's injuries for fear of the vampire attacking him no matter what Angel said.
"Simon, how fast do you think I am?" Angel asked then, and Simon's eyes widened before he forced himself to concentrate on his work and simply answer.
"I'm not sure, sir. I've never seen - "
Angel dashed around the room, picking up the various tools and antiseptics he knew Simon would use even if he didn't need all of them, and then methodically lined them all up next to Sam's chuckling body, all of this done in a mere ten seconds - probably less.
"Eight point five, five, six seconds," Sam said with the pride of a six year old tying his shoes for the first time. "Go Chief!"
Angel mussed Sam's hair before turning to stare at the flabbergasted captain. "You should probably put that away. All of us - River, too - could have that out of your hands and you on the floor before you could so much as squeeze the trigger. No need, of course, but we could."
"He's no bad man," Sam rolled his eyes, vamping out and giggling when Simon flinched backward, exclaiming, only to be caught on the shoulder by Angel and given a slight shove back to Sam, who was now waiting patiently.
"Sam, put your face away, please, you're scaring the doctor."
"Shouldn't he learn to get used to it? Anyway, he hasn't seen Little Brother's, so this should get him nice and prepared."
"Right, nice and prepared for Connor's much less dramatic game face. Away, please, Samuel."
"You'd think he was ordering the kid to put somethin' he caught back outside," Mal muttered, but then Sam growled at him, fangs still apparent.
"Samuel." Angel's voice allowed no room for argument.
With another snarling noise, Sam's face receded and he froze perfectly still as Simon mustered up the courage to work on him some more.
"He's not gonna hurt ya, Simon," Kaylee said drunkenly. "His dad's there ta protect ya."
"Forgive me, Kaylee, I've never worked on vam - vampires before," Simon forced out as he examined old scars on Sam's body that seemed to be what what formed a latticework on his shoulder.
"For these to be this ingrained, given your enhanced..." Simon palpated the region and Sam hissed, but a look from Angel kept him still perfectly motionless. "There's something...embedded...in his shoulder."
Simon shut himself up and simply slathered a numbing agent onto it. Sam flinched backward, whimpering, but then Angel walked back up and took hold of Sam's face again, "Look at me. Look at me."
Sam didn't whimper again, but tears fell as Simon cut a horizontal incision into Sam's skin just above the scarred tissue and began removing it layer by very fine layer.
Simon could tell the captain was staring the whole while, but before long was only focused on the work he needed to do. Slowly, painstakingly, he alternated removing thin layers of scarring and injecting numbing agent into what remained until finally...
The captain swore liberally in Mandarin as thin wafts of black smoke drifted upward and the smell of ozone filled the infirmary.
"Oh, my God," Simon whispered, trying not to let his horror and revulsion show. Beneath the layers of what turned out to be cauterized - for lack of a better term - scar tissue, there was a set of crosses composed of various types of metals, it seemed, embedded into Sam's skin, burning him literally from the inside out for who knew how long.
Angel forced himself not to show any anger or dismay lest he upset his eldest more, but kept his face carefully blank as Simon finally suggested sedating Sam like his brother and River.
Simon removed the crosses, one by one, tossing them in the medical waste bin and feeling almost as repulsed by them as he knew his patient likely was. This wasn't the holiness the Shepherd spoke of, this was a sacrilege. These crosses were no one's protection, only someone's idea of fun. And punishment undeserved, even he could see.
"I can't have him conscious if I intend to repair this," Simon whispered as quietly as he possibly could into Angel's ear, hoping Sam was too busy whimpering to hear him.
"Leave it, his body will repair it and there won't be a scar. Now that the...now that they're gone, he'll feel better."
Simon ignored the tears he could see gathered in Angel's eyes. Angel ignored him back altogether, "Sammy, do you care to stay still while I go get your brother's jersey? I'll only be a minute."
Sam's only response was another, softer whimper, and Angel frowned, another tear trailing down his face as he finally stepped up and took hold of Sam's arms, arresting his sudden movements as he allowed Simon to sedate Sam, too.
Standing still momentarily and breathing deeply through his nose, Simon tried to calm down and Angel rather pitied him. But he had more important things to think about right now.
"I'll be right back," Angel said and before anyone could see either Mal or Simon saw where he went, he was gone.
Kaylee's eyes were wide, however, and she smiled thickly. "Whoa, he's a fast one. Like an angel...like he's got wings you just can't see."
"That's just his name, mei mei, Mal corrected, glaring darkly at the direction Angel had gone. "No angels on my boat."
"You're wrong, cap'n," Kaylee insisted, taking his hand. "'Cause I just saw one. He was all dark and shiny even if he didn't have wings. Not ones we could see anyhow."
Mal honestly didn't know what to say so he simply stroked Kaylee's hair until she fell back to sleep and then left the infirmary. He could crack wise to the preacher or Inara all he wanted, the fire of turmoil being stoked in his belly wouldn't be assuaged by a few untoward jokes. He hated Angel and couldn't understand why. He couldn't even bring himself to call the man out of his name and that sense of obedience scared him more than anything else. Mal obeyed no one, that was for sure.
He was the captain of this wayward ship and no one was going to steal that out from under him, not in his own mind, sure as hell not outside it.
No one.
So why was he so afraid?
...The best of us can find happiness in misery...
Angel snatched up Connor's discarded Los Angeles Kings jersey and shook it out, brushing off the small amount of dust that had gotten on it from its position on the floor, before turning to go back to the infirmary.
Captain Reynolds was standing in his way and suddenly Angel could remember with the clarity of a church bell the day he left his family's home forever.
You'll want to move away from the door now, Father.
Shaking his head, Angel frowned and stared at Mal, the first vestiges of anger seeping into his face and tone. "Move."
"See, here's where I think you have things a little backward," Mal said, pointedly stepping into their haphazardly messy suite and folding his arms as he tried to act like the fact that he couldn't meet Angel's eyes was his own doing.
"This is my ship and on my ship the only one givin' out orders and havin' 'em followed would be me. I told you that when you got on and I don't see a reason in the 'verse why I should do a thing you say, vampire or no."
Angel's face closed even further and he stepped forward only to have Mal diverge into his path. Even now, he could feel the man shaking, but slightly. He admired Mal's courage even as it pissed him off.
"You don't want to go down this road with me, boy," Angel said calmly, and Mal blinked, shocked and even frightened as, inward of his own head, he heard those very words issuing from his own mouth, only he was speaking to Dr. Tam...Simon...
Go through it, but don't ever expect ter come back!
Mal resisted the urge to yell with everything he had in him. "You an' yours got on and in less than a day's time have turned my boat inside out. I should leave you lay and..."
Mal froze. He was saying his own words again (this time, to Shepherd Book...elsewhere...) and it made his skin crawl.
He looked again at Angel, who was still staring at him, his face closed, blank, clutching the jersey. "Demon."
Angel actually froze and then looked upward, "Are you happy, Cordy? Buffy? I actually have a reason to say it!"
He looked back down at Mal Reynolds and said pointedly, "Duh, dumbass. I've only been telling you as much. But that's not your worry, as you like to say. I'm a Seer. I've been one all my life, even when I was a normal human - "
"So you are human - "
"I'm talking."
"My ship! My crew!"
"You have them. You'll have them as long as you need."
"Stop talking in riddles!"
"Stop being obtuse."
Mal was breathing heavily now, just itching to punch this hyun dan in the mouth so hard he couldn't say another word as long as he was on Mal's boat...but he couldn't.
"Who the hell are you?" Mal snarled in a low voice. "Bad enough I got an Alliance Fed trussed up somewhere on my ship, bad enough I got a bunch of strays makin' trouble I don't need - you're not even all human and I'm just supposed to - "
"I believe the technical term is many-times great-grandfather," Angel sighed, leaving Mal blinking before backpedaling.
"I - no way in Hell."
Angel gave a little laugh, chased by a sardonic smile, "Funny you should phrase it like that."
"What the hell are you - "
"Short version: I wasn't exactly a monk during my first human years. Far from it, though I believed deeply - never stopped, hence my anger. I hated that God would reject me in such a way as to let me become what I did, that the very way of life I loved - something my father never believed about me, but I don't care to go into religious semantics - would reject me so. If God truly felt me an aberration, then I was going to be that aberration, in His Holy Name, I decided.
"My logic wasn't exactly sound. You don't really get sound logic out of a demon, but I've always had an obsession with love...different targets, but my feelings have never wavered in their strength. I can't help but do three things: protect, love, or destroy, depending on whom I'm directing those feelings or actions toward. Anyway, I thought I'd slaughtered the entire village, taken care of everything that had reminded me of my whole life there...but I was wrong."
Mal couldn't stop staring. His anger and fury over Kaylee had been shoved into a backseat and he hated it, but he couldn't stop listening.
"It was customary back then and even into the mid-twentieth century to send women who'd been unchaste or even raped to convents. I've always found that disgusting, but as much as everyone likes to make of the power of one, the power of many still takes precedence in most cases, including one such as that.
"Popular opinion brands the girl a whore and she's punished for something she wanted equal or no part in and the male party gets off scot-free. As it turned out, your many-greats-grandmother was one of those unfortunate women. They were made to do hard labor and never allowed to see their children, who were either adopted out or raised by friends of the family elsewhere.
"My last argument with my father was about Cara. I..." Angel breathed deeply, anger smoldering in his eyes even at events so long past. "Her family blamed her for 'letting me defile' her; I wanted to marry her, but her father hated me and wouldn't allow it, especially after finding out she was with - carrying my child. That sent him over reason's edge. The tragedy of his daughter bearing my child was something he couldn't abide. I begged my father to try to do something to stop it. He said I needed to learn my lesson once and for all and, maybe, seeing the 'true' - "
And here Angel's face became livid with anger and Mal felt his breath hitch. "Consequences of my actions might teach me to fetter myself and my ungodly urges in the future, lest it happen to another girl. In the end, I left, but I was too late - she was gone, sent away, and I was never even allowed to see my child. My - well, they weren't my friends, but I didn'..."
Mal could hear a strange accent leaking slowly into Angel's voice the longer he spoke, but his head was too full of what he was learning to comment on it or much of anything.
"Anyway, they couldn' understan' why I cared so much abou' 'er fate - she was just a woman after all an' what were they, really, but little more' horses in most peoples' minds. I hurt so badly I drank all o' me money away, but...I coul' see, even then. I've always dreamt o' things. Me mate did the same, bu' that was connected ter her Callin'. She weren' a Seer such as me an' me mam befer me - she died, just like me father's first family all died...he thought himself a walkin' sin just as he taught me.
Angel laughed sadly, "An' me, o' course. Another thing me father felt was some sin 'e'd earned. Me whole existence. Devil's child, they called me. I almos' wasn' even Christened. Damned, they felt me. I begged God's fergiveness. I canno' describe the pain. Then again, I don't have ter describe it ter ye, do I? That seperation..."
Mal felt that same strange lance of pain shoot through him as had on Serenity when he'd watched those airships launching. As had taken over as he watched near everyone under his command die...except Zoe. Clenching his eyes shut and pulling them open again, he gritted his teeth at Angel, but the man wasn't watching him just then.
Angel snapped out of the faraway expression that had taken over his face, but the change in his voice was still there, "I don' know what happened after that - her name was Cara, before ye ask, the Irish fer 'friend', but a name, as well - but it saved her from me an' what I became. An' her misfortune o' being sent ter hard labor an' destitution o' sorts actually kept her alive.
"I don' know if we had a daughter or a son...all I know is down an' down the line went somehow an' finally, here, five hundred an' seventy-five years later, even now...yer blood calls ter mine. Because it be mine. It sings. You be o' me blood, just as me sons're - I suppose ye're wondering why ye react ter me the way ye do. It's not yer fault."
Mal was staring at Angel, his very soul tingling with the truth of Angel's words despite his not wanting to believe them.
"You're goin' out my airlock," he whispered, unable to yell and walk away like he desperately wanted to.
"Do you really think so?" Angel asked calmly, sighing in his own mind.
"Right now," Mal forced out, but it wasn't nearly as resolute as he usually sounded.
"I'm going to give the son I do have back his jersey," Angel countered, his voice back to normal. "Then you might want to check on Mr. Dobbs. He'd do anything to get free and turn this whole crew in for anything he can think of."
Mal's eyes widened and then he raked his hand through his hair. "You and me ain't finished with this."
"Duh, little one," Angel said softly again, this time with a very slight smile. "I'd tell you in Irish, but you'd never understand me. That's pointless at the moment, though. Pain is scary and Jayne is of the same mind - for now. I'll give my son his jersey and then..."
A very dangerous smile grew on Angel's face and Mal found himself torn again. He wanted to step away, he wanted to join Angel and Jayne in their torture. "You go to your mei-mei. She needs you. But first...show me to our Mr. Dobbs."
Mal would never admit this to anyone, but at that particular time he was glad of this inability to disobey.
...Say my name and hiss in the same breath - I dare you to say they taste the same...


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1. London teenagers Cameron Ford, Adam Welland and Will Peachey had a romantic meal in their local McDonalds' in Kingston.
Note the centrepiece made from straws, and the fake candles for atmosphere.
2. The boys were asked to leave by McDonalds' staff, but they managed to stay on thanks to other diners and staff members who over-ruled the decision.
Ailbhe Malone is the UK lifestyle editor for BuzzFeed and is based in London.
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Prions are infectious proteins that result from the structural conversion of proteins into a self-templating conformation. In yeast, a number of glutamine/asparagine-rich proteins have been shown to undergo prion conversions from a soluble form to an insoluble amyloid form. A variety of evidence suggests that these prions may act as epigenetic regulatory elements. Interestingly, numerous human proteins also contain prion-like domains (PrLDs) - domains with compositional similarity to the yeast prion-forming domains. Six of these have recently been linked to various age-related degenerative disorders, heightening the interest in PrLDs. More than 200 other human proteins contain PrLDs, suggesting that aggregation of these proteins may be involved in other diseases. However, despite the importance of these domains in human disease, the sequence basis for their aggregation and toxicity is still poorly understood. Preliminary attempts to define the sequence basis for aggregation of PrLDs recently resulted in the development of PAPA (Prion Aggregation Prediction Algorithm), the first algorithm demonstrated to be able to distinguish between proteins with and without prion-like activity. This proposal builds on these early successes, using a combination of yeast and Drosophila genetics, in vitro experiments, and bioinformatics to rigorously define how the amino acid sequence of PrLDs contributes to aggregation and toxicity.
In Specific Aim 1, a newly developed assay will be employed to quantitatively determine the compositional requirements for aggregation and toxicity of PrLDs.
In Specific Aim 2, a combination of in vitro assays and Drosophila experiments will be used to explore how the propensity to convert to oligomeric and amyloid species affects toxicity in vivo. Finally, in Specific Aim 3, sophisticated bioinformatics methods will be used to incorporate this information into improved prediction algorithms, allowing for the identification of candidate disease-associated or regulatory PrLDs.
In the past few years, a number of previously unexplained degenerative diseases, including some forms of dementia, have been linked to mutations in proteins containing prion-like domains. These mutations cause the proteins to accumulate in cytoplasmic aggregates. Understanding the basis for this aggregation, as well as how these mutations cause toxicity, will potentially aid in the treatment of these terrible diseases.
|Cascarina, Sean M; Ross, Eric D (2014) Yeast prions and human prion-like proteins: sequence features and prediction methods. Cell Mol Life Sci 71:2047-63


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As the health reform debate heats up in summertime Washington, discussions center around how to make our current system more efficient, provide better value for the dollars spent, and extend coverage to those without it. The Senate Finance Committee options papers and the House tri-committee report devote whole sections to proposals to reduce health care costs. These proposals consider ways to find savings from working more efficiently, and slowing the growth curve -- savings that could help pay the substantial cost of comprehensive health reform.
A full discussion of the issues looks at both federal spending and at national expenditures on health. How can the private sector contribute to a slowing of national health care expenditures? Are there examples of models that have been implemented in the marketplace and demonstrated they can save money? If incorporated into reform, how much of an impact would they have on the federal budget? What are the constraints that prevent the Congressional Budget Office from scoring such savings? What about the impact on total national health expenditures? What are the respective roles of providers, consumers and legislators in changing the way we do business in health care?
To address these and related questions, the Alliance for Health Reform and the United Health Foundation sponsored a July 13 briefing. Panelists were Len Nichols, director of the Health Policy Program at the New America Foundation; Simon Stevens, executive vice president of the UnitedHealth Group and chairman of the UnitedHealth Center for Health Reform & Modernization; Gail Wilensky, senior fellow at Project HOPE; and Janet Marchibroda, chief healthcare officer at IBM. Ed Howard of the Alliance moderated.
(If you want to download one or more slides from these presentations, contact us at info@allhealth or click here for instructions.)
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AROUND TOWNCities press VTA to move on transit woes
Firing off a proverbial warning shot, Mountain View and seven other West Valley cities sent a letter recently to the Valley...Original post made on Jan. 6, 2016
Last comment by @Intelligent Realist, on Jan 8, 2016 at 11:03 am | 7 comments | 2867 Views
AROUND TOWNPower outage caused by traffic collision
Roughly 1,630 utility customers in Mountain View were in the dark Tuesday night after a traffic collision damaged electrical...Original post made on Jan. 6, 2016
Last comment by Dori, on Jan 6, 2016 at 4:55 pm | 4 comments | 3735 Views
AROUND TOWNDay Worker Center's role more crucial than ever
The Mountain View Day Worker Center is like a firewall holding back a wave of social ills, said executive director Maria...Original post made on Jan. 3, 2016
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SPORTSLocal sports fans can nab Super Bowl volunteer jobs
Organizers of the halftime show for Super Bowl 50 taking place at Levi's Stadium in Santa Clara invited Bay Area sports fans...Original post made on Jan. 5, 2016
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AROUND TOWNGoogle housing axed in city's general plan
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AROUND TOWNPeninsula cities call for new Bus Rapid Transit options
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AROUND TOWNTraffic deaths, injuries topped the news in 2015
The Mountain View Police Department faced a tough year in 2015, after six traffic fatalities and a sharp increase in bike...Original post made on Dec. 30, 2015
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AROUND TOWNMV Walmart worker speaks out about low wages
News of President Obama's visit to Mountain View's Walmart Friday prompted an employee of the store to speak up about not...Original post made on May. 9, 2014
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OTHER ISSUESHidden in plain sight: Human trafficking reaches into Silicon Valley
Throughout the Bay Area and even in wealthy and sophisticated communities such as Palo Alto and Mountain View, people are...Original post made on May. 8, 2015
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SCHOOLS & KIDSNew laws taking effect for California drivers in 2016
Several new driving laws will come into effect in the new year aimed at improving safety for child passengers, motorists,...Original post made on Jan. 1, 2016
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AROUND TOWNTwo arrested in New Year's Eve brawl
Two bar patrons were arrested in downtown Mountain View on New Year's Eve after they allegedly attacked a security guard...Original post made on Jan. 4, 2016
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OTHER ISSUESYear in review: City grapples with affluence and affordability
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ELECTIONSRace for Assembly seat draws more aspirants
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AROUND TOWNLandlords' hidden spending may trigger new election law
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AROUND TOWNSecret history of MV's Berlin Wall slab
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AROUND TOWNA refuge for domestic violence victims
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Norse Projects is showcasing its 2013 fall/winter editorial through the lens of photographer Sven Eselgroth, a Manchester and London-based fashion and music photographer. Currently on a two-month bike trip across Scandanavia, Eselgroth made a pit stop in Copenhagen to collaborate with stylist Kristin Wold and model Vitus to produce the editorial, and uses the city streets as a backdrop. The latest release from his "Scandinavian Fashion Trip," Eselgroth's road trip is centered around working with and showcasing upcoming and established brands that define the Scandanavian fashion scene.


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After a slow beginning, investment trusts have become enthusiastic participants in the PEP market. Investors can now choose from 163 trusts that are eligible for PEP investment, and 33 management companies offer plans, which among them attracted a total investment of pounds 140m in the first half of the year.
You can shelter up to pounds 6,000 (all your annual general PEP allowance) of investment trusts in a PEP each year, so long as they are qualifying trusts - that is, trusts which have at least 50 per cent of their holdings in European Union shares or bonds. If your holdings are in non-qualifying trusts, a limit of pounds 1,500 applies for PEP inclusion.
The level of charges is a potential attraction of investment trust PEPs. The annual management charge on the underlying trusts is, on average, lower than that on unit trusts. Newer investment trusts tend to have higher charges than older ones, but they are still of the order of 1 per cent, whereas many unit trusts now have fees of 1.5 per cent.
Admittedly, there are almost always additional charges for buying an investment trust through a PEP. Some investment trust PEPs, however, carry no initial fee, while the dealing charges for buying and selling trust shares are mostly between 0.2 per cent and 1 per cent. In comparison, stockbrokers' commission on share transactions often starts at 1.65 per cent.
The majority of plans are open to both lump-sum investments and regular savings. The minimum amounts accepted may be as little as pounds 20 a month or pounds 250 for lump sums, and typical figures are pounds 50 and pounds 1,000 respectively. Plans may be angled towards providing income, capital growth or a mix of the two.
Of course, PEPs offered by management groups generally include only the company's own trusts. Investors can usually switch holdings from one trust to another within the range with little or no charge.
A couple of managers, however, go beyond their own trust range. Alliance Trust specifies that the first pounds 1,500 invested must go into one of its own trusts, Alliance and Second Alliance, but this can be topped up with any of around 60 trusts from a variety of management groups. Ivory & Sime's plan offers a choice of the company's trusts on a self-select basis, but also three managed portfolios which include trusts chosen across all management groups. Two of the portfolios are designed for capital growth, the third for income.
It is also possible to invest in a mix of trusts through managed and self-select plans offered by stockbrokers and independent advisers. The former would be based on the PEP manager's choice of trusts, while a self- select plan gives the investor a free hand.
Generally, however, these are more expensive, as dealing costs tend to be higher and there may be a minimum commission charge, so they are more suitable for larger investments.
Many of the plans offered by the management groups are based solely on investment trusts, but in a few cases shares or unit trusts may also be included.
The most important issue is performance. Here, investment trusts have an excellent long-term record: over 10 years, they have outpaced rival products by a healthy margin.
In fact, as the table shows, the best investment trust in an ordinary savings scheme would have beaten the best unit trust in a PEP. When the tax advantages of the PEP are added on, the return is pounds 1,500 better than its nearest rival.
o Liz Walkington works for investment trust manager Ivory & Sime.
PEP comparisons
10-year performance
Best investment trust PEP pounds 11,030
Best investment trust pounds 10.291
Best unit trust PEP pounds 9.504
Av. investment trust PEP pounds 8,827
Best with-profits endow. pounds 7,999
Av. unit trust PEP pounds 7,689
Av. unit trust pounds 7,169
Av. with-profits endow. pounds 7.041
Returns are based on a pounds 35 per month investment over 10 years to 1 April 1995 for best and average UK equity income investment trusts and unit trusts inside and outside a PEP plus best and average with-profits endowment plans. Investment trust figures are on a mid-market to mid-market basis; unit trust figures are on an offer to offer basis; endowment figures are actual maturity values. Averages are on an arithmetic basis.
Source: HSW, Money Marketing
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Depeche Mode Announce North American Leg of World TourThe run kicks off on August 23rd in Salt Lake City, UT.
Dave Gahan Plays a Dictator in Depeche Mode 'Where's The Revolution' VideoDave Gahan stands upon an oversized podium like an angry dictator shouting messages at his devoted minions.
Depeche Mode Drop Politically Charged New Single, 'Where's The Revolution?'The lyrics are likely to hit home on both sides of the pond.
New Depeche Mode Song 'Where's the Revolution' Coming this WeekIn today's political climate, a song called "Where's the Revolution" sounds pretty timely.
Rock and Roll Hall of Fame 2017 Nominees AnnouncedAmong the artists nominated for the first time are Bad Brains, Depeche Mode, Pearl Jam, and Tupac Shakur.
Depeche Mode Return with New Album and 2017 TourThe band's European dates kick off May 5th in Sweden.
Wayback WednesdayToday's trip down memory lane takes us back 28 years to 1986. In March of '86, Reagan was President, the Chicago Bears were Super Bowl Champions and Depeche Mode was about to put out their fifth album Black Celebration.
Depeche Mode Brave Pouring Rain In 'Should Be Higher' Live VideoTheir 24-date US tour kicks off tonight in Michigan -- mostly in dry arenas.
Former Depeche Mode Member Alan Wilder Auctions MercedesFormer Depeche Mode member Alan Wilder has not only put his prized Mercedes 300SL up for sale but the musician has gone into detail about the car's history in hopes to find a suitable bidder.
Depeche Mode's 'Concert For The Masses' Rose Bowl Show, 25 Years LaterTwenty five years ago, on June 18, 1988, the Depeche Mode played the 101st show of their Music For The Masses Tour. The concert would prove to be the most important performance of their career.
Depeche Mode Dedicate Birthdays To Clean Water CharityThe members of Depeche Mode are asking fans to make a financial donation to charity: water instead of sending gifts on their respective birthdays this year.
Depeche Mode, fun. & Muse Among Austin City Limits HeadlinersThe 12th annual 'Austin City Limits Music Festival' will feature acts from a variety of genres and eras, as part of its first-ever two-weekend run this October.


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Most skyscrapers don't do much more than house people or offices, but one day, they could also help solve problems like urban pollution and waste collection. For the last nine years, eVolo Magazine has held a competition for the problem-solving skyscrapers of the future. Here are a handful of this year's ideas, selected from over 600 entries from around the world. Scroll through the images above for more solutions.
While most of the concepts were designed for cities, a few were made for more remote locations. The Rainforest Guardian, from Chinese architects Jie Huang, Jin Wei, Qiaowan Tang, Yiwei Yu, and Zhe Hao, was made to sit on the edge of the Amazon, capturing and storing rainwater in the rainy season to help fight fires in the dry season. On top, the building could also be used as a lab for scientists studying the area.
The floating Seawer skyscraper, from South Korean architect Sung Jin Cho, is designed to travel through oceans filtering plastic waste out of the water. Housing, offices, and gardens are built into the top of the structure, along with a recycling plant that can process the plastic particles. Everything runs on renewable energy generated from the sun, ocean, and the plastic itself.
In China, where only three out of 74 major cities manages to meet minimums standards for air quality, the Project Blue skyscraper could both remove pollution and create new fuel for cars. Designed by Yang Siqi, Zhan Beidi, Zhao Renbo, and Zhang Tian, the building floats through cities using a chemical reaction with carbon monoxide in the air to create fuel, and then delivers it to underground pipes.
Most of these ideas are far from feasible right now, but they're exactly the kind of crazy provocations that could eventually spur real change.
Slideshow Credits: 01 / Henry Smith, Adam Woodward, Paul Attkins; 02 / Thibaut Deprez; 03 / Mark Talbot, Daniel Markiewicz; 04 / Yuan-Sung Hsiao, Yuko Ochiai, Jia-Wei Liu, Hung-Lin Hsieh; 05 / Tsang Aron Wai Chun; 06 / Umarov Alexey; 07 / Christopher Christophi, Lucas Mazarrasa; 08 / Jason Orbe-Smith; 09 / ang Siqi, Zhan Beidi, Zhao Renbo, Zhang Tian; 10 / YuHao Liu, Rui Wu; 11 / Jie Huang, Jin Wei, Qiaowan Tang, Yiwei Yu, Zhe Hao; 12 / Qiu Song, Kang Pengfei, Bai Ying, Ren Nuoya, Guo Shen; 13 / Jin Cho; 14 / Matt Bowles, Chad Kellogg;


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Our first interviewee, Rita, runs a successful architectural practice in Maputo, Mozambique.
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Leadership is hard, especially when confronting policies and people that simply don't work anymore. Caving in to doubt and criticism just creates organizational mirages that perpetuate dysfunction.
What does it take to be a great leader?
Once upon a time, birth order and socioeconomic status were considered powerful determinants in who would s...
The dreaded question of What should I do with my life? is a common one. From childhood to adulthood, we ask it of ourselves and others ask it of us. The decision can be tortuous.
As our world changes, it will be important for us to expand our ideas and expectations of leadership, leadership models and who we see as leaders.
The making of women leaders is a collaborative process, where future leaders need to embrace the lessons learned by those who forged a path before them.
Leaders and leadership scholars of the future may be looking at the world in a whole new way -- with the brain firmly in mind. And the journey has really only just begun.
We need leaders who step back and make us do more of the work. As the Lone Ranger rode off into the sunset, he left it to the town -- as he should have -- to deal with the future, trusting that they were up to it.
What sets leaders apart is their ability to go for the vision of their desired outcome, no matter the resistance, the obstacles or the challenges.
Got a passion for buying sneakers? It could be a good sign, with a poll finding that people who buy three pairs of sneakers or more a year are far mor...
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The BONIFANTES Boys' Choir was founded in the year 1999 and has won a place among the cream of the choir ensembles in the Czech Republic in its short life. Talented boys from the age of 4 to 18 years of age work in seven departments of the singing school known as "BONIFANTES School of Arts" with capacity of 350 students. Almost 100 boys visit the concert department alone and the choir takes part in up to 100 concerts and performances each year.
Among the successes achieved so far are a number of concert tours (Germany, Great Britain, France, Austria, Belgium, Holland, Spain, Italy, Denmark, Slovenia, Bosnia & Herzegovina, Croatia, Slovakia and USA) and performances in operas (e.g. G.Bizet – Carmen, G.Puccini – Tosca, G. Rossini – Il barbiere di Siviglia) and films (Napoleon). The choir performs in harmony with Czech orchestras on an annual basis (J. Jirásek– Kouzlo českých Vánoc, A.L.Webber – Requiem, V.Wimmer – Apel svědomí, L.Cherubini – Missa solemnis, C. Orff – Carmina Burana, Dmitrij Shostakovich – The Symphony No. 13 "Babij Jar"). Over the past three years of its activity, the choir has taken part in six international competitions (Iuventus Mundi Cantat – Festa Musicale Olomouc 2x, Prague Days of Choral Singing "Praga Cantat", Musica Sacra Praga, B. Martinů International Competition, European Festival for youth people in Neerpelt), at which it has been awarded with eleven gold and four silver medals, three titles of competition prize-winner, and a prize for outstanding conducting performance for the choirmaster.
The choir is regularly welcome by prestigious international festivals, including "Smetanova Litomyšl". Between most distinguished successes belong 1st prize "CUM LAUDE" at the European Choir Festival in Neerpelt and the title of overall winner at the Festival of Song2004 inOlomouc ahead of another 159 competitors. Among large range of recordings made by the choir is the world premieres with the Chamber Philharmonic Pardubice (e.g. Luigi – Cherubini – Messe Solene Brever in Es, W. A. Mozart – Missa in C, Jan Jirásek – Kouzlo českých Vánoc. Artistic guidance is provided to the BONIFANTES Boys' Choir by its founder, Mr. Jan Míšek.


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Intermediate Filaments and Microtubules
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Microtubules are part of the cell's cytoskeleton, helping the cell resist compression, move vesicles, and separate chromosomes at mitosis.
Learning Objective
Describe the roles of microtubules as part of the cell's cytoskeleton
Key Points
- Microtubules help the cell resist compression, provide a track along which vesicles can move throughout the cell, and are the components of cilia and flagella.
- Cilia and flagella are hair-like structures that assist with locomotion in some cells, as well as line various structures to trap particles.
- The structures of cilia and flagella are a "9+2 array," meaning that a ring of nine microtubules is surrounded by two more microtubules.
- Microtubules attach to replicated chromosomes during cell division and pull them apart to opposite ends of the pole, allowing the cell to divide with a complete set of chromosomes in each daughter cell.
a flagellum is a lash-like appendage that protrudes from the cell body of certain prokaryotic and eukaryotic cells
Small tubes made of protein and found in cells; part of the cytoskeleton
A cellular structure like a skeleton, contained within the cytoplasm.
Full Text
As their name implies, microtubules are small hollow tubes. Microtubules, along with microfilaments and intermediate filaments, come under the class of organelles known as the cytoskeleton. The cytoskeleton is the framework of the cell which forms the structural supporting component. Microtubules are the largest element of the cytoskeleton. The walls of the microtubule are made of polymerized dimers of α-tubulin and β-tubulin, two globular proteins . With a diameter of about 25 nm, microtubules are the widest components of the cytoskeleton. They help the cell resist compression, provide a track along which vesicles move through the cell, and pull replicated chromosomes to opposite ends of a dividing cell. Like microfilaments, microtubules can dissolve and reform quickly.
Micrtubule Structure
Microtubules are hollow, with walls consisting of 13 polymerized dimers of α-tubulin and β-tubulin (right image). The left image shows the molecular structure of the tube.
Microtubules are also the structural elements of flagella, cilia, and centrioles (the latter are the two perpendicular bodies of the centrosome). In animal cells, the centrosome is the microtubule-organizing center. In eukaryotic cells, flagella and cilia are quite different structurally from their counterparts in prokaryotes.
Intermediate Filaments
Intermediate filaments (IFs) are cytoskeletal components found in animal cells. They are composed of a family of related proteins sharing common structural and sequence features. Intermediate filaments have an average diameter of 10 nanometers, which is between that of 7 nm actin (microfilaments), and that of 25 nm microtubules, although they were initially designated 'intermediate' because their average diameter is between those of narrower microfilaments (actin) and wider myosin filaments found in muscle cells. Intermediate filaments contribute to cellular structural elements and are often crucial in holding together tissues like skin .
Stained Keratin Intermediate filaments
Keratin cytoskeletal intermediate filaments are concentrated around the edge of the cells and merge into the surface membrane. This network of intermediate filaments from cell to cell holds together tissues like skin.
Flagella and Cilia
Flagella (singular = flagellum) are long, hair-like structures that extend from the plasma membrane and are used to move an entire cell (for example, sperm, Euglena). When present, the cell has just one flagellum or a few flagella. When cilia (singular = cilium) are present, however, many of them extend along the entire surface of the plasma membrane. They are short, hair-like structures that are used to move entire cells (such as paramecia) or substances along the outer surface of the cell (for example, the cilia of cells lining the Fallopian tubes that move the ovum toward the uterus, or cilia lining the cells of the respiratory tract that trap particulate matter and move it toward your nostrils).
Despite their differences in length and number, flagella and cilia share a common structural arrangement of microtubules called a "9 + 2 array." This is an appropriate name because a single flagellum or cilium is made of a ring of nine microtubule doublets surrounding a single microtubule doublet in the center .
Microtubules are the structural component of flagella
This transmission electron micrograph of two flagella shows the 9 + 2 array of microtubules: nine microtubule doublets surround a single microtubule doublet.
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Key Term Reference
- actin
- Appears in these related concepts: Adherens Junctions, Muscular Dystrophy, and Rigor Mortis
- cell
- Appears in these related concepts: Cells as the Basic Unit of Life, Citric Acid Cycle, and Levels of Organization
- centrosome
- Appears in these related concepts: Interphase, The Mitotic Phase and the G0 Phase, and Meiosis II
- chromosome
- Appears in these related concepts: Genomic DNA and Chromosomes, Genes as the Unit of Heredity, and The Role of Genes in Prenatal Development
- cilium
- Appears in these related concepts: The Role of Energy and Metabolism, Chromalveolata: Alveolates, and Physical and Chemical Barriers
- element
- Appears in these related concepts: Development of the Periodic Table, Elements and Compounds, and The Periodic Table
- eukaryotic
- Appears in these related concepts: Bacterial Transformation, Characteristics of Prokaryotic Cells, and The Plasma Membrane and the Cytoplasm
- mitosis
- Appears in these related concepts: Early Eukaryotes, Growth of Bone, and Gametogenesis (Spermatogenesis and Oogenesis)
- myosin
- Appears in these related concepts: Microfilaments, Muscle Tissues and Nervous Tissues, and Structure and Function of the Muscular System
- nanometer
- Appears in these related concepts: Discovery and Detection of Viruses and Light
- organelle
- Appears in these related concepts: Centrosome, General Staining Methods, and Characteristics of Eukaryotic Cells
- plasma membrane
- Appears in these related concepts: Gram-Positive Cell Envelope, Injuring the Plasma Membrane, and Components of Plasma Membranes
- prokaryote
- Appears in these related concepts: Bacterial Chromosomes in the Nucleoid, Limitations to the Classic Model of Phylogenetic Trees, and Classification of Prokaryotes
- protein
- Appears in these related concepts: Purifying Proteins by Affinity Tag, The Relationship Between Genes and Proteins, and Proteins: Sources, Uses in the Body, and Dietary Requirements
- uterus
- Appears in these related concepts: Uterus, Female Reproductive Anatomy, and Onset of Labor
- vesicle
- Appears in these related concepts: Mechanics of the Action Potential, The Golgi Apparatus, and Neurotransmitters
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Source: Boundless. "Intermediate Filaments and Microtubules." Boundless Biology Boundless, 20 Sep. 2016. Retrieved 23 Feb. 2017 from https://www.boundless.com/biology/textbooks/boundless-biology-textbook/cell-structure-4/the-cytoskeleton-62/intermediate-filaments-and-microtubules-323-11460/


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Will Coneys of Arlington, Virginia, reigned champion of the one on one tricking battle in Midtown Atlanta. Red Bull Throwdown presents the new standard of physical movement, where all styles will battle to find the most complete tricker. 16 athletes made the finals on Saturday to compete head to head until only one stood as the winner.
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Running with Scissors (2006)
Plot Summary
The story of how a boy was abandoned by his mother and how he, later, abandoned her. The year he'll be 14, the parents of Augusten Burroughs (1965- ) divorce, and his mother, who thinks of herself as a fine poet on the verge of fame, delivers him to the eccentric household of her psychiatrist, Dr. Finch. During that year, Augusten avoids school, keeps a journal, and practices cosmetology. His mother's mental illness worsens, he takes an older lover, he finds friendship with Finch's younger daughter, and he's the occasional recipient of gifts from an unlikely benefactor. Can he survive to come of age?- Written by <email@example.com>
1978. Fourteen year old Augusten Burroughs narrates the story of his love/hate relationship with his mother, Deirdre Burroughs. As a child, Augusten loved and wanted to be like his theatrical acting mother, who aspires to be a famous writer, with her person being more renowned than her writing. She is critical of writers in general while not achieving that wanted fame because of not being a gifted enough a writer. Her writing is fueled largely by her manic depression. Augusten's now divorced parents had a turbulent relationship, his alcoholic father, Norman Burroughs, who is now largely out of his life by Norm's own choice. To deal with her mental issues, Deirdre has been seeing therapist Dr. Finch, whose actions are largely motivated by a singular issue. Out of circumstance, Augusten strikes a relationship with Dr. Finch's disparate but completely eccentric family: his quietly nervous wife, Agnes Finch; religiously fanatic eldest daughter Hope; rebellious younger daughter Natalie; and thirty-five year old recently adopted son Neil Bookman, who was and still is one of his patients. In Norm's self-imposed abandonment and Deirdre's own dealings with her unstable mental state, Augusten reluctantly finds in the Finches a surrogate family, far from the "normal" family within which he dreams for himself. But in his relationship with the Finches, Augusten will learn where he wants his mother to fit in his life, and what he has to do for himself to have the life he wants given the cards he was dealt. He will also find that he has a kindred soul who was not obvious to him at first glance.- Written by Huggo
Young Augusten Burroughs absorbs experiences that could make for a shocking memoir: the son of an alcoholic father and an unstable mother, he's handed off to his mother's therapist, Dr. Finch, and spends his adolescent years as a member of Finch's bizarre extended family.- Written by IMDb Editors
It is the 70s and Augusten Burroughs (Joseph Cross) is a young gay child who spends hours upholding his mother Deidre Burroughs (Annette Benning) with emotional support as she attempts to forge her career as a poetess...See full synopsis » (Warning: contains spoilers!)


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Accepting new patients
Dr. White graduated AOA from Case Western Reserve Medical School in Cleveland, Ohio in 1978 and completed his residency in Internal Medicine and fellowship in Cardiology at Letterman Army Medical Center from 1978 thru 1983. He then joined the Staff of Letterman Army Medical Center as the Director of the Cardiac Catheterization Laboratory and Director of Cardiovascular Research in 1983. He became the Director of the Catheterization Laboratory at Walter Reed Army Medical Center and Director of Cardiovascular Research in 1985 until leaving the military to become Director of the Catheterization Laboratory at Ochsner Clinic in 1988. In 1994, he became the Director of Invasive Cardiology for HCI Medical Center in Glasgow, Scotland until returning to Ochsner in 1997. He currently serves as Professor of Medicine and System Chairman of Cardiovascular Diseases. He has received teacher of the year awards at Letterman and at Ochsner. He was recently honored as the Physician Leader of the Year at Ochsner. Dr. White was Editor-in-Chief of Catheterization and Cardiovascular Interventions between 2000 and 2010. He has published more than 200 peer-reviewed manuscripts and presented more than 150 scientific abstracts. His major interests have centered around "device" development and include the co-invention of a coronary angioscope, a laser angioplasty catheter, and the Wiktor™ coronary stent. Another major area of interest has been the integration of coronary and peripheral vascular interventional therapy including the clinical utility of renal and carotid stents, limb-salvage angioplasty, pharmacologic and mechanical thrombolysis for acute ischemia, and acute stroke intervention. His current research interests involve the detection of biomarkers for vascular disease, the utililty of ablation devices for hypertension and the development of percutaneous heart valves. Dr. White maintains an active clinical referral practice evaluating and treating patients with coronary, peripheral vascular, neurovascular, valvular and structural heart disease.Read more
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Likelihood of recommending Dr. White to family and friends is 4.3 out of 5


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At ThorTech Solutions we believe in using the powerful combination of leading edge techniques and proven industry standards to improve time to market and ensure the quality of software systems.
There is much going on in the industry today towards achieving these goals. Our focus is on a collection of values, principles, and practices for modeling software that can be applied on a development project in an effective and lightweight manner ensuring the delivery of applications on time with high reliability and within budget.
Cloud Consulting
Sifting through the marketing and promise of the Cloud for your business can only go so far. You need to understand the full financial impact these technologies can have in your organization. We can assist in evaluating your technical, business and time to market requirements to determine the best path and roadmaps for feasibility and enhanced ROI through and hybrid cloud solutions.
Hybrid Cloud Solutions
We specialize in applications with very high availability and redundancy requirements by combining on-premise data centers with cloud solutions.
Consulting Partner - Amazon Partner Network
Amazon Web Services (AWS) provides a highly reliable, scalable, low-cost infrastructure platform in the cloud. As an AWS Consulting Partner, ThorTech Solutions assists companies building secure, highly available, hybrid cloud applications.
ThorTech Solutions specializes in the application development of highly scalable, mission critical, back-end systems and services accompanied by desktop and web based graphical user interfaces. We have in depth knowledge of developing efficient and robust infrastructures for multithreaded programming that address the issues and challenges when dealing with concurrency for multi-core processors. We use both functional and dynamic language programming paradigms in providing you with a competitive working quality solution.


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If you like the dark wood finishes and classical decor details of traditional furniture, but worry that your house will look too much like your grandma's, that's a sign that you might be yearning for the sophistication and elegance of transitional design. The Harlowe & Finch collection was designed with the intention of bringing classical elegance to the modern home, and it carries off this mission smoothly and effortlessly. Depending on how you curate these pieces, furniture from Harlowe & Finch can add an extra special something to elegant contemporary or timeless traditional room decor. Find a sophisticated and cosmopolitan piece from this collection to fulfill your bedroom, dining room, or living room design and storage needs. Harlowe & Finch features exquisite wood craftsmanship of quartered and flat-cut oak veneers in two base color choices with accent colors thrown in for variety and panache.
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Slowly runs over the land Never stoping Never ceding Always running Wether in rain or snow or lighting Never stoping for the kid swimming Or the person drowning Not caring about anything Except running Always moving Doomed to run The river always flows
© Copyright 2017 ZAE. All rights reserved.
Status: Finished
Genre: Poetry
Another great one! I really, really, love this one. Particularly the line: Doomed to run. Probably because I am currently reading The Long Walk by Richard Bachman (Stephen King) so that line had a little different, double meaning to me this morning. Nice one! :o)
Book / Action and Adventure
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Low Cholesterol Leads to an Early Death – Evidence from 101 Scientific Papers
Are you worried about high cholesterol? The scientific evidence in this book will shock you! The statistics from the scientific literature actually show that having LOW cholesterol means you are more likely to die earlier. The 101 scientific papers in this book show: • Low cholesterol levels are associated with a shorter life. • Low
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Desperate to detoxify
Q I am feeling very sluggish and want to feel perkier before winter sets in. I've read about detox diets in magazines - can you recommend one?
A Advocates say that chemicals, bugs, alcohol and antibiotics can make the gut more permeable so that instead of passing straight through and out, toxins are diverted to the liver. The liver is the in-house detoxifier, but some say we overburden it so that a high load of toxins circulates in the blood, causing all manner of ills.
These include all the conditions for which conventional medicine offers so few solutions, including headaches, excessive mucus, rashes, aches and pains. Add to these lethargy, bad breath, indigestion and weight gain, and that more or less covers all of us. Apparently, some people detoxify well, some sluggishly and some hardly at all. Any diet high in fruit and veg and low in caffeine, alcohol, fats and processed foods probably offers the same benefits as some of the complicated regimes described in the many, often contradictory, books. The Total Detox Plan by Dr Sarah Brewer seems sensible if you need something to tell you to exercise, eat properly and drink water.
Flu fighters
Q I work in advertising, am in my mid-40s, quite fit, but prone to stress and overwork. The last thing I need this winter is flu. Do you recommend flu jabs and are there reasons for not having one?
A Cut down on the work and stress and leave your immune system to fight off flu. There is no epidemic forecast this year. The best way to avoid flu is to urge any colleagues who think they have it to stay at home until they have recovered. The jab is fairly benign, but can cause the rare and potentially dangerous neurological condition Guillain-Barré syndrome, which can cause paralysis. It's really only worth having the jab if the risks of flu outweigh any potential danger from the jab. For a healthy 40-year-old, flu is a nuisance for a week. The people most likely to develop complications from flu, such as pneumonia, are over-75s, anyone in a residential home and those with diabetes, long-standing chest, heart or kidney diseases or lowered immunity due to chemotherapy or steroids. They should all have the jab.
Vein hopes
Q I get recurrent varicose ulcers in my legs. They are slow to heal and painful when knocked, which often happens when my grandchildren visit. The nurse at my GP's surgery dresses each one and they do eventually heal. But I would like to prevent any further ones developing. Any ideas?
A Keep your skin as moisturised as possible using E45. Graduated support stockings, for which you need to be measured by a pharmacist, encourage the blood to flow back up towards the heart and protect against minor scrapes and cuts, which can lead to ulcers. Cuddling grandchildren is fine, but take their shoes off if they are clambering over your legs, and keep your legs out of harm's way while they ride bikes and scooters. You will need antibiotics if your ulcers fail to heal. New medications containing growth factor give hope for the future but are not yet widely available.
The homeopathic remedy Cargo Veg 6c is sometimes recommended for elderly people with varicose ulcers. Surgery to correct varicose veins does not always prevent ulcers but is often advised as a preventive measure.
These answers are intended to be as accurate and full as possible, but should never be used as a substitute for visiting a doctor and seeking medical help. If you have a question for Dr Robinson, email firstname.lastname@example.com or write to her c/o The Health Editor, The Guardian, 119 Farringdon Road, London EC1R 3ER. She regrets that she cannot enter into personal correspondence.
Thanks to guardian.co.uk who have provided this article. View the original here.


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William Shakespeare
Additional words by AE Housman
UK Cathedral Tour
2 – 22 February 2017
UK Cathedral Tour
18 – 29 April 2016
Middle Temple Hall, London
26 March – 6 April 2016
Temple Church, London
24 August – 5 September 2015
Périgord and Quercy, France
2 – 13 August 2015
England's idealistic army marches to war, certain of a swift and glorious victory. France proudly rallies to defend her borders from invasion. But as nations clash, it is the common soldiers who pay the ultimate price in the bloody mud of the battlefield.
Marking the 600th anniversary of the Battle of Agincourt and the ongoing centenary of the First World War, Antic Disposition presents a new production of Shakespeare's Henry V.
Performed by a combined cast of British and French actors, the uplifting production celebrates the rich and complex historical relationship between our two nations – from the Hundred Years War to the Entente Cordiale.
"Antic Disposition have put together a truly amazing production of Henry V which left me spellbound and speechless ... Freddie Stewart is a wonder in the title role and delivers an outstanding performance as the young monarch."
"This full-bodied, full blooded First World War Henry has a new depth in the hands of this talented young cast and production company."
The Londonist
"Freddie Stewart's Henry V is exceptional. This ingenious production is not to be missed."
The Upcoming
"A beautifully crafted production. Powerful, shocking and deeply moving."
Stage Review
"A wonderfully imaginative and evocative staging of one of Shakespeare's great histories, in a sublime location."
Everything Theatre
"Antic Disposition and directors Ben Horslen and John Risebero have managed to bring off one of the most impressive revivals of a Shakespeare play that I have seen in recent years."
British Theatre
"Antic Disposition have created yet another production that makes Shakespeare remarkably engaging and exciting ... Poignant, perturbing and excellently acted."
Ginger Hibiscus
"A moving and thoughtful production executed by a skilful team of actors and creatives – catch it while you can."
The Public Reviews
Ben Horslen
John Risebero
John Risebero
Composer /
Musical Director
Christopher Peake
Lighting Designer
Tom Boucher
2016 Cast
Floriane Andersen
Louis Bernard
Maurice Byrne
Marius Hesper
James Lavender
Andrew Lewis
Stephen Lloyd
James Murfitt
Dean Riley
Jake Samuels
Freddie Stewart
Louise Templeton
2015 Cast
Floriane Andersen
Maurice Byrne
Callum Coates
Marius Hesper
Andrew Hodges
Alex Hooper
Victor Klein
Mark Middleton
James Murfitt
Dean Riley
Freddie Stewart
Louise Templeton
Geoffrey Towers


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Street styles draw influence from various places. It is arguably the designer's job to target these influences and translate them into something tangible for the consumer. Crane.tv, the British video magazine, has an interesting piece which documents two conversations with modern designers: Katie Eary and Agi & Sam. Both parties speak on their favorite fashion influences, touch on how style transcends domestic boundaries and what goes into their creative process. Interspersed throughout the video are clips of pro BMX rider Kenzo de Witte, who rides around the streets of North London geared with some pieces from both designers' latest collections.