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- Home
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A proud history of innovation and support
Yorkshire Bank was founded in 1859 in Halifax, West Yorkshire. Yorkshire Bank has 182 retail branches, a strong personal customer base and a business banking capability through a UK-wide network. Yorkshire Bank is a trading name of Clydesdale Bank PLC.
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Piner PTA and Willis Music, with the support of Turfway Park, host the 1st annual Summer's End Music Blast! Running from 5:00 p.m. to midnight, the event includes live music and plenty of kids events (between 5 & 7pm) such games, face painting, hay rides, and more. All proceeds from ticket sales go to Piner PTA to purchase educational necessities for the students of Piner Elementary. Tickets are just $5 at the door, $15 per family.
Head to The Spotted Goose for Cash Mob #7 From 4-6pm you can enjoy crafts from The Art Spark, goodie bags for the first 20 people with a purchase and cupcakes from Yum. Great opportunity to support a local business!
Kenton County Animal Shelter holds it's Fifth Annual Pet Fair, starting at 10am. Our friends from the Kenton County Library will be there too.
Make a work of art at Brazee Street Studio at their Family Open House from 10am to 1pm on Saturday. This month's theme is Kilncarved Coasters.
Here's one for Mom & Dad –-> The Mason-Deerfield Arts Alliance (MDAA) and Deerfield Township present the second annual Powder Keg 5k Walk-Run Trail Race at the Kings Mansion, 1720 E. Kings Ave. Start time will be 9:00am. Registration begins at 7:30am. Cost is $10 per person pre-registration and $15 the day of. This race is not conducive for strollers. www.runningtime.net.
Whole Foods Market in Rookwood hosts Kids Can Cook Too at 10am. Perfect for kids from 3-12.
Cincinnati Library — Books Alive! has two fun performances this Saturday – Price Hill Library (Noon) & West End Library (3pm). Includes a hands-on craft.
Another for Mom & Dad –> Saturday Night's "Date Night Movie" in Washington Park is Casablanca…
Northside Presbyterian Church – End of Summer Block Party from 3-7pm. Our friends from Happen Inc will be there providing arts activities! There will also be games and plenty of other family friendly activities!
Head to Camp Ernst in Burlington for its annual S'MORE FESTIVAL from 1-5pm. Enjoy access to all the great camp activities – we're talking zipline, archery and more – for the price of tickets ($1-5) and refreshments will be sold, along with a silent auction. Proceeds help provide scholarships for kids in need so they can attend camp.
The Taft Museum hosts Hot Music – Cold Treats – a fun, old-fashioned neighborhood concert with free ice cream from UDF! Music by the Firelytes Steel Drum Band. Runs 2-4pm.
The Florence Freedom take on the Washington Wild Things at 6:05pm.
Head to MainStrasse Village for their 4th Sunday Antiques Sale. 30+ vendors will be selling from 9:30am – 3pm. Do some shopping, perhaps pop in to Stoney's All Things Princess and Fairy or MK's Totes and make a day of it! Get some ideas from this post we wrote in December on Shopping in The Village.
Head to Newport's historic district at Noon for the Newport Car Show and Sidewalk Sale from Noon to 5pm.
The Cincinnati Reds take on the St. Louis Cardinals this weekend.
Taste of Blue Ash is THIS WEEKEND!!! Need we say more?
Gravelrama XXXXII – Junior racing and up hill racing takes place all weekend in Cleves!


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Tom Price
Language isn't the only barrier that complicates collaboration among scientists from different countries. Many researchers also find themselves struggling to communicate with foreign colleagues while adhering to export regulations that restrict information exchanged within the United States.
Become a member or log in to view the full text of this article.
OSA Members get the full text of Optics & Photonics News, plus a variety of other member benefits.
Publish Date: 01 June 2008


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Los Girasoles I Hotel
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TripAdvisor Reviews Los Girasoles I Hotel Granada
Travel Blogs from Granada
And now for the Granada experience
... we went to the Tourist Office. The most pleasant young lady there tried to help us,.. even offering us a 'Granada Pass' for €37.50 each that would get us into 4 different attractions (including the Alhambra),.. but we didn't want the other 3 on offer. She then told us that there are a number (about 300, I believe), day tickets that go on sale each morning,.. for that day,.. at 8.00am at the Alhambra ticket office. You need to be there,.. queuing from 7.00 am to be a chance ...
High Altitudes
Whilst exploring granada last weekend I'd spotted the snow capped peaks in the Sierra Nevada...I'm a sucker for snow so I worked out the buses and have just enjoyed a hugely relaxing day in the small mountainous town of Geujar Sierra. The peaks are crowned with metal crosses which the locals trek up to on the 2nd May to deck with flowers and wild Rosemary. I was below snow level, but a cool wind was blowing from ...
In Awe at the Alhambra!
... ordering drinks and claiming dibs on our free tapas...yum! We also ate at a FresCo, a huge salad-bar type restaurant with pizza and pasta, so we loaded up on fresh veggies, a rarity on this trip.
The highlight of the trip was our visit to the Alhambra. We had been advised to buy our tickets online well before arriving in Granada, which we did, so we walked all the way up the hill (felt like a mountain!) for ...
¡A La Marcha!
... rolled along the ground, balanced by the peddler on either side. Within the circle there were 3 seats that rotated with the circle and swung back and forth on their own axises. They were playing rock/jazz fusion, and wherever they went they had a huge crowd following them and dancing.
After tapas, we walked to la Discoteca Granada 10, selected solely because it was ladies night so we got in free and had a few free drinks. We ...
First Week: Check
... doesn't come home today, it will be Monday. In Spain, there aren't doctors on the weekends. There have been strikes going on since August with regards to healthcare and it's really hard to get in to have surgery or see a doctor. Some people have been waiting since the summer to have surgeries! As long as it's not life threatening, you go on a waiting list. We think that's why Marcos got called in on such short notice.
We've also started running again this week! The food ...


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Northstar Ratings are powered by Northstar Travel Media. Please email firstname.lastname@example.com if you have any questions or comments regarding the rating of an individual property.
Give your group the ultimate New Orleans experience at the New Orleans Marriott, recipient of the 2015 Pinnacle Award from Successful Meetings Magazine. Located in the French Quarter and step from the convention center, and world-class restaurants, our hotel offers over 80,000 square feet of flexib...
AAA Rating is a rating system for lodgings and restaurants in North America by American Automobile Association.
This rating was reported by the venue and has not been verified by Cvent.
Gold Key & Golden Platter awards for excellence in Convention management.
2015 Successful Meetings Pinnacle Award
The New Orleans Marriott ranks among the Top 10 of all Marriott Convention and Resort Network Hotels in the U.S. This includes ranking #2 for Sales, #4 for Planning & #5 for Overall Event Satisfaction for 2015!
72 Hours
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Luxurious French Quarter landmark hotel located near many attractions in the heart of New Orleans.Rising 41 stories, experience spectacular views of the downtown skyline and the Mississippi River .5 Fifty 5, serving a fresh approach to Louisiana cuisine, a chic wine bar, as well as an on-site Starbucks, FedEx Kinko s business center, and a fully-equipped health club.
Combined 41st Floor capacity can never exceed 300 guests.
Welcome to the Big Easy! Our hotel's location on Canal Street is just steps away from everything New Orleans and the French Quarter is known for!
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Located in the heart of the New Orleans Central Business District, three blocks off Canal Street, our French Quarter area hotel on St. Charles Avenue in Louisiana has 9,000 square feet of flexible function space & 250 superior guest rooms.
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A Four-Diamond treasure in the Central Business District, InterContinental New Orleans enjoys one of the city's most coveted locations, only two blocks from the French Quarter. The Morial Convention Center and the Louisiana Superdome are also nearby


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Dellas Boutique Hotel
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- Continental Breakfast
- Room service
- Free High-Speed Internet
- Wheelchair accessibility
- Free parking
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- Free High-Speed Internet
- Wheelchair accessibility
- Free parking
- Continental Breakfast
- Room service
TravelPod Member ReviewsDellas Boutique Hotel Kalambaka
Our stay at Dellas was splendid. It was far and away the nicest hotel we stayed in during our nine days in Greece. The rooms are sumptuously appointed with quality linens and furniture, and each room has a large balcony where one can spend her/his time gazing at the incredible Meteora landscape (though not every room has a view of the mountains/karsts). The wifi in the hotel seemed strong and steady and there was plenty of parking in front of the building.
The staff was, without a doubt, exceptional. They truly went above and beyond to ensure that each and every guest felt welcome and valued. Each member was a wealth of information on the area; I am confident our experiences in the area were enhanced by the extra insider bits and pieces they shared with us. Their additional effort was even felt in the decadent breakfast that was laid out with care and happily attended to every morning.
Dellas is located right on the border of Kastraki and Kalambakka, so is quite convenient as both are walkable from it. There are a few restaurants very close to the hotel, and there is also a nice walking path to the old town of Kastraki, making it possible to avoid walking on the busy highway.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews Dellas Boutique Hotel Kalambaka
Travel Blogs from Kalambaka
Part 8 - Athens to Kalambaka
... which is free. However, there are no jobs and the unemployment rate is around 26%. In the 18 to 25 year age group, it is much higher. Greek parents who can afford it, will send their children overseas for 2 years to get a further degree, and then they will stay in that country and get a job there!!
Greek students have just returned to school after their almost 3 month summer holiday!!
20% of global shipping belongs to Greece, and is their No ...
Today we visited a couple of monasteries on the cliff tops of meteora. I had never heard of meteora before last year when Sarah told me it was a must see. She wasn't wrong! This place was amazing and completely awe inspiring. The monks built their monasteries on the tops of enormous and largely inaccessible cliffs in the north of Greece. Nowadays they are pretty easy to get to as the site is a unesco world heritage site. We went to 2 of the monasteries. One of them was actually ...
The mystery of Monasteries
... You see it and wonder how people managed to built something like that.
All of these monasteries are located at Met�ora in Greece, and most are perched on high cliffs and accessible by staircases cut into the rock formations. They were created to serve monks and nuns following the teachings of the Greek Orthodox Church.Of the six intact monasteries, ...
A welcomed end to a long day!
... On top of the columns the marble appears to be one straight piece but it really has a slight curve to it. Besides the Parthenon Leonardo De Vinci's Universal Man painting also exhibits the Golden Ratio.
Ok this one you are all going to LOVE in Greece there are small waste paper baskets next to the toilets well no big deal we have waste paper baskets in our bathrooms at home. Well these ...
Monestries on Mountains.
... seen so far, it really would not be out of place in a sci-fi movie (just like the bridge at Patra!). We were lucky enough to have a bit of cloud cover as well so we had the sandstone columns leading your eyes up to the monestries that guide your view to the majestic rocks that were halo'd by the swirling clouds, the effect was photographic overload!!
Inside the monestries the artwork is worthy of the vatican! The chapels are covered from floor to ceiling ...


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Joseph Benavidez and Demetrious Johnson are all business prior to their title fight, while Michael Bisping and Brian Stann are chomping at the bit for a chance at one another. See both serious stared watch video >>
Rory MacDonald vs Stephen Thompson headline the card on June 18th. watch video >>
Fighters stare each other down the day before fighting at UFC 199. The UFC 199 card has the follow fights: Luke Rockhold (c) vs. Michael Bisping Dominick Cruz (c) vs. Urijah Faber Max Hollo watch video >>
Watch as the fighters from UFC 200 and the other International Fight Week events face-off for their staredowns at the UFC 200 press conference on Friday, April 22, 2016, in Las Vegas. Website: http: watch video >>
At the UFC's 'Go Big' press conference, the top stars in upcoming events, including Conor McGregor and Jose Aldo, squared off with their opponents Friday evening in Las Vegas. Subscribe: http://www. watch video >>
UFC 187 staredowns, Periscope cam. Anthony Johnson vs. Daniel Cormier Chris Weidman (c) vs. Vitor Belfort Donald Cerrone vs. John Makdessi Travis Browne vs. Andrei Arlovski watch video >>
http://www.MMAWeekly.com/ -- The UFC 162: Silva vs. Weidman full weigh in at the Mandalay Bay Events Center in Las Vegas. The fighters weighing in are Anderson Silva, Chris Weidman, Frankie Edgar, Ch watch video >>
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Watch all fighters appearing in Saturday night's event weigh in LIVE from the Mandalay Bay Events Center in Las Vegas. watch video >>


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text: There are lots of fantastic days out in Lincolnshire and a fabulous choice of farm attractions, zoos, countryside visits, Lincolnshire gardens, ice cream parlours, and great things to do with the kids. The visitor attractions here at DaysOutInLincolnshire.uk work hard to offer great days out with the kids, fabulous places to go for lunch or for ice cream and some of Lincolnshire's loveliest animal attractions, gardens and heritage sites. Some of our members provide the best places to stay in Lincolnshire, and the whole team at the Farm and Countryside Attractions Group works together to make sure that anyone looking for things to do in Lincolnshire will find a day out that they'll enjoy.


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Day Trip to Petra from Amman
Approx. 10 Hours
Private Tour
Around 07:00 AM
Are you looking for Day Trip to Petra from Amman? Experience Petra Day Tours from Amman. Drive to the ancient "rose-red" city of Petra, carved into the rocky mountains of Jordan's desert and Explore it's Siq, Treasury, Royal Tombs and More
- All transfers by a private a/c vehicle with English speaking assistant
- Pick up services from your hotel in Amman and return
- English speaking driver
- Entrance fees to Petra Archeological sites
- Local English speaking spot guide in Petra (about 2-3 hrs)
- Service charges and taxes
- Any extras not mentioned above
- Any meals or drinks
- Tipping
Experience Petra day tours from Amman. Your tour manager will pick you up from your hotel in Amman. Then we will drive towards the rose red city of Petra, the biggest attraction of Jordan. Petra was first established around the 6th century B.C. by the Nabataean Arabs, a nomadic tribe who settled in the area and laid the foundations of a commercial empire that extended into Syria. Upon arrival you will begin the trip on horse back to the canyon, the so called Siq, and then by foot to the most beautiful monument: the Treasury. Among other monuments you will see are the Street of Facades, the Royal Tombs and Pharaoh's Castle. Petra was also chosen to be one of the New 7 Wonders of the world. After the tour, we will drive you back to your hotel in Amman after enjoying a day trip to Petra from Amman, Jordan.
- Prices
Tour price currency is set to USD but you can pay in Euro or British pound. The prices quoted per person per trip and prices are always updated to ensure you receive the lowest price possible. Once your tour is confirmed we guarantee the price will not be changed.
- Children Policy
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We welcome you to access any of our past sermons. Click the audio link to hear the sermon being preached. Video sermons are now available on our Facebook; you may click here to begin viewing them.
Sermons (3)
|Jesus Loves and Accepts Me
|Mark 10:13-16 (Part of the Submerged series).
|Preached by Trey Wooten on July 17, 2016 (Sunday Worship Service).
|The Hour of Darkness
|Mark 14:32-42 (Part of the Dying to Live series).
|Preached by Jim Testerman on March 20, 2016 (Sunday Worship Service).
|When God Calls
|John 15:16 (Part of the [Misc] series).
|Preached by Jim Testerman on February 14, 2016 (Sunday Worship Service).


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Transnational Entrepreneurship: Determinants of Firm Type and Owner Attributions of Success
Jennifer Sequeira
University of Southern Mississippi
Jon C. Carr
University of Southern Mississippi
Abdul A. Rasheed
affiliation not provided to SSRN
Entrepreneurship Theory and Practice, Vol. 33, Issue 5, pp. 1023-1044, September 2009
Building on a typology of transnational firm types, developed by Landolt, Autler, and Baires in 1999, we examine whether immigrant attitudes toward the host country and their degree of embeddedness in the home country can predict the specific type of transnational enterprise that an immigrant is likely to begin. We also investigate whether the determinants of success of transnational enterprises vary by firm type. Based on a sample of 1,202 transnational business owners drawn from the Comparative Immigrant Entrepreneurship Project database, our analyses indicate general support for our hypotheses. More specifically, we found that transnational entrepreneurs' positive perceptions of host country opportunities and greater embeddedness in home country activities helped predict the specific type of ventures they would undertake. Further, the degree of embeddedness in the home country may influence the determinants of success for these types of firms. Depending on firm type, owners attributed their primary success to either personal characteristics, social support, or to the quality of their products and services.
Number of Pages in PDF File: 22
Date posted: October 8, 2009
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Furnished Lake Mansion near Chicago
1860 N Black Point Ln, Lake Geneva, WI 53147
Interior, exterior and aerial photos page: 1
This is a waterfront mansion for sale in Linn, Wisconsin that is on Geneva Lake. This mansion home is located about 2 hours outside of Chicago to the north.
Description: "Once In A Lifetime~Rare Opportunity To Purchase 464 Feet of Outstanding Lake Frontage. Exquisite Estate set on 5 Acres & a Private Pond! 11,000 SqFt Thelen Built Custom Home. Great Room w/ Ornate Ceilings & Hand Carved White Marble Fireplace. Lounge w/ Panoramic Lake Views + Custom Mahogany Bar & Axminster Carpet. Master Suite w/ Grand Master Bath. Library w/ Fireplace & Leather Flooring. 40′ In-ground Pool & Pool House. Pier 595 w/ 4 Boat Slips. This Elegant Property Is Being Sold Furnished."
- 11,000 square feet
- Bedrooms:5
- Bathrooms:7
- Full/3 Half
- Total Rooms:18
- 1860 N Black Point Ln, Lake Geneva, WI 53147
- Listing courtesy of Lake Geneva Realty
See more properties like this:
Listed price:


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98,272pages onAdd New Page
this wiki
this wiki
History of location is unknown.
Points of Interest
Fallville is a small suburb in the state of Iowa. As the birthplace of Barry Allen and home of his parents, this typical midwestern town has seen a few visits by the Flash.
- Dr. Henry Allen
- Nora Allen
- Barry Allen
- Daphne Dean
- Allen Family
- Peter Reid [citation needed]
- David Reid[citation needed]
See Also
Links and References
History Section Needed!
The history section for this article is either absent or contains very little information. You can improve this article by adding as much relevant historical information as possible. Articles should be written from an "in-universe" perspective as if they were written by a historian living in the DC Universe.


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Please be a respectful, man of your word and have a good heart.
My physical taste in men (of course could be different, I think it's all about chemistry) - light skin, beautiful eyes, tall (5.9 and above), looks young or younger than me.
If you have beautiful eyes it's a bonus


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Jaguar for Sale
Selected Filters:Type of Ad: Vehicles for Sale Make: Jaguar
1997 Jaguar XK8 Roadster
Stratford, NJ
1997 JAGUAR XKR, ROADSTER....... BEAUTIFUL Coblat Blue paint with a STRIKING....... Cream leather interior.....FULL POWER of course.. and speaking of POWER the Jaguar V... More
1989 Jaguar XJ12 Convertible
Stratford, NJ
Just arrived another beauty this is a one owner that looks and runs great!!! This is a true dream to drive!!!!! Rare V12 Engine... More
1994 Jaguar XJ6
Stratford, NJ
1994 JAGUAR XJ6, THIS IS A FULLY LOADED ORIGINAL SPARKLING CLEAN CAR EVERY OPTION PERFECT IN EVERY WAY A DREAM COME TRUE PRICED TO... More
1989 Jaguar XJ6
Stratford, NJ
1989 JAGUAR XJ6, NICE XJ 6 with stunning Silver paint... ALL the Jag options and LOVINGLY maintained by the owner .... and a BONUS... More
1984 Jaguar XJS V12 Luxury Leather
Stratford, NJ
Rare Orange Metallic!!! one owner!!! very low miles just arrived all original in and out priced to sell........loaded with many options........ More
2006 Jaguar XJ8L Extended Body
Stratford, NJ
Just arrived Estate Car..... Jag is an XJ8L. The L stands for long version which means its 5 inches longer than the standard model.... More
1985 Jaguar XJ
Staunton, IL
leather int, p windows, sun roof, 6cyl, auto, good paint, ran when parked... More
1995 Jaguar XJS
Staunton, IL
1995 Jaguar XJS Conv, nicely kept, good body, new paint and top, godo orig int, full power, 6 cyl, auto, fact a/c... More
2001 Jaguar XJ
Staunton, IL
limited edition vanden plas, nice paint and leather int, 4.0 at, full power, moon roof... More
1978 Jaguar XJ6L Custom
Staunton, IL
nice body and paint, good orig int, fuel inj car, no motor. Call for photos... More
1969 Jaguar XKE
Lebanon, TN
This is an extremely strong,tight,exciting original 50553 mile 4.2 XKE OTS.This car has always been a southern state car and is void of any rust,rust... More
1952 Jaguar XK-120 Convertible
Nashville, TN
Beautifully RESTORED XK120 Roadster by JDs BRITISH CARS NASHVILLE The Korean War comes and ends. A Soldier comes home from the battlefield, to celebrate his life... More
1954 Jaguar XK-120 Roadster
London, United kingdom
Jaguar XK120 caused an absolute sensation when it was launched at the 1948 Motor Show. In the post-war era of rationing, general austerity and... More
1960 Jaguar MK 2 3.4 Manual O/D
North Canterbury, New zealand
What is it about these old Jags that almost sixty years on still makes us go all misty eyed? Other old motors just grow into... More
1956 Jaguar XK-140 FHC 1956, 5 speed gearbox and disc brakes.
Waalwijk, Netherlands
Jaguar XK 140 FHC 1956, 5 speed gearbox and disc brakes. This elegant burgundy red Jaguar XK 140 Fixed Head Coupe was built in 1956... More


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Dave Barrys Greatest Hits
"Mr. Barry is the funniest man in America and we should encourage him. Buy this book."THE NEW YORK TIMES BOOK REVIEWWhat Pultizer Prize-winning humorist Dave Barry did for American history in DAVE BARRY SLEPT HERE and for getting older in DAVE BARRY TURNS FORTY, he does for...everything else in America! The rapacious consumer of overpriced real estate, He Man action figures, and homemade beer sounds off on all the things that make life as we know it both ridiculous and sublime.
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What is it?
RealD 3D is the new generation of entertainment, with crisp, bright, ultra-realistic 3D images so lifelike you feel like you've stepped inside the movie. RealD 3D adds depth that puts you in the thick of the action, whether you're taking a voyage through an undiscovered land or dodging objects that seem to fly into the theatre.
RealD is the world's most widely used 3D cinema technology and it's 100% digital so it delivers a stunningly realistic and fully immersive entertainment experience every time. RealD 3D is so advanced that you don't just see what's happening on the screen, you can really feel it. Don't just watch a movie, experience the new dimension of entertainment with RealD 3D.
Now Playing in RealD3D
The Lego Batman Movie
Opens: 2/10/2017
Doctor Strange
Opens: 11/4/2016
Opens: 12/21/2016
Rogue One: A Star Wars Story
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The Great Wall
Opens: 2/17/2017
Opens: 12/21/2016
Underworld: Blood Wars
Opens: 1/6/2017
Resident Evil: The Final Chapter
Opens: 1/27/2017
xXx: The Return Of Xander Cage
Opens: 1/20/2017
Journey To The West: The Demons Strike Back (Mandarin w/Chinese & English s.t.)
Opens: 2/3/2017
The Lego Batman Movie - In 4DX
Opens: 2/10/2017
Opens: 11/23/2016


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CRI's new website that seeks to engage, educate, and empower patients and their loved ones to learn more about cancer immunotherapy as a treatment option across numerous tumor types.
Cancer patients, donors, scientists, and other supporters all stand behind the Cancer Research Institute. Read their stories and learn about what motivates each of us to keep fighting against cancer.
By running in a marathon or hosting a bake sale, you can make a real difference for our scientists in the fight against cancer and allow them to bring newer immunotherapies to more patients.
We gratefully accept donations made in memory or in honor of a loved one. Your gift will be acknowledged to whomever you specify.
A $1 million challenge to spur innovative solutions to challenges in cancer immunotherapy research.
Curious about the latest developments in cancer immunotherapy research? Listen in as leading scientists discuss immune-based treatments across numerous cancer types in our free "Cancer Immunotherapy and You" webinar series.
When the Cancer Research Institute was founded in 1953, we knew then that immune-based treatments would transform cancer medicine. In more than six decades since, we've made numerous groundbreaking discoveries that have given more patients new hope today.
Are you a patient or caregiver? Visit our website TheAnswerToCancer.org for more information on immunotherapy for melanoma.
Melanoma is one of the major cancer types for which new immune-based cancer treatments are currently available, with more in development. This page features information on melanoma and immunotherapy for melanoma patients, and highlights the Cancer Research Institute's role in working to bring effective immune-based cancer treatments to people with melanoma.
Melanoma is the deadliest form of skin cancer. Although it comprises less than 5% of skin cancer cases, melanoma accounts for the great majority of skin cancer-related deaths. Over the past few years, immunotherapy has dramatically changed the landscape of melanoma treatment. The immune-based treatment Yervoy (ipilimumab) was the first drug shown to extend survival among patients with advanced melanoma and was approved by the FDA in 2011. A number of exciting new immune-based treatments in development promise to save more lives.
In 2016, in the U.S., approximately 76,380 new melanomas will be diagnosed, and about 10,130 people will die from this disease. That is more than one life claimed every hour in the U.S. Moreover, the incidence of melanoma is on the rise in the U.S. and around the globe.
The main risk factor for melanoma, as for all skin cancer, is exposure to natural and artificial ultraviolet (UV) light. According to the American Academy of Dermatology, more people develop skin cancer from tanning than develop lung cancer from smoking.
Although melanoma is often easier to detect in its earlier stages than most cancers, it is also more likely to spread (metastasize) to other parts of the body. Metastasis represents the most significant cause of death from the disease. The 5-year survival rate for localized (stage I and II) melanoma is 98%; however, this drops to 17% in cases where cancer has metastasized to distant sites or organs. (These numbers are based on historical data collected up to 2011, and may change as immunotherapy is more widely used.)
Since 2011, eight new drugs have been FDA approved for the treatment of melanoma, including four immunotherapies and four targeted therapies. The immunotherapy drugs are ipilimumab (Yervoy®), pembrolizumab (Keytruda®), nivolumab (Opdivo®), and talimogene laherparepvec (T-VEC, Imlygic™). The first three drugs are checkpoint inhibitors that "take the brakes off" the immune system and enable it to fight cancer; the last is an oncolytic virus therapy.
The targeted therapies are vemurafenib (Zelboraf®), dabrafenib (Tafinlar®), trametinib (Mekinist®), and cobimetinib (Cotellic®). These drugs target common genetic mutations, such as the BRAFV600 mutation, found in a subset of melanoma patients.
Despite the recent FDA approvals of these drugs, some patients with advanced metastatic melanoma still have a significant risk of mortality. A substantial unmet need remains for new successful therapies in patients with this disease.
The side effects of immunotherapy are different than chemotherapy. Whereas chemotherapy's side effects—nausea, hair loss, vomiting—stem from its destruction of all rapidly-dividing cells, both healthy and cancerous alike, immunotherapy's side effects are often immune-related, and commonly include inflammatory symptoms such as rash, diarrhea, pruritus, and colitis, amongst others. These immune-related adverse events can be quite serious and even fatal, but are typically reversible when effective treatment guidelines on side effect management are followed.
Melanoma has long been considered a promising target for immunotherapy and has been a major focus of immunotherapy clinical development efforts. Several immunotherapies are currently approved by the FDA and many more are in clinical development. Current immunotherapy approaches for melanoma fall into seven main categories: checkpoint inhibitors, oncolytic virus therapies, cancer vaccines, adjuvant immunotherapy, adoptive cell therapy, monoclonal antibodies, and cytokines.
In 2011, ipilimumab (Yervoy)—which targets the CTLA-4 pathway—was approved by the FDA to treat unresectable or metastatic melanoma. The approval came on the heels of the first phase III clinical trial ever shown to improve overall survival in patients with the disease, with median overall survival of 10.1 months, versus 6.4 months in the control group.[i] Long-term follow-up of patients who received ipilimumab showed that a large percentage were still alive at the two- and five-year mark. Some of the earliest treated patients remain cancer-free more than 10 years out.[ii]
This approach was pioneered by CRI's Scientific Advisory Council director James P. Allison, Ph.D., who was the first to show that an antibody that blocked a molecule called CTLA-4 on T cells could lead to cancer regressions in mice. Ipilimumab was tested in late-phase clinical trials by Jedd D. Wolchok, M.D., Ph.D., director of the CRI/Ludwig clinical trials network and associate director of CRI's Scientific Advisory Council.
Pembrolizumab (Keytruda) and nivolumab (Opdivo)—two checkpoint inhibitors that target the PD-1 pathway—received FDA approval in 2014 for melanoma that did not respond to prior treatment. In one trial, patients treated with pembrolizumab had an overall response rate of 33%, compared with 12% for ipilimumab.[iii] The approval of nivolumab was based on a randomized clinical trial where the overall response rate was 32% in nivolumab-treated patients.[iv]
In 2015 and 2016, the FDA expanded its approval of pembrolizumab and nivolumab as first-line treatments for unresectable or metastatic melanoma, regardless of mutational status. As a single agent, ipilimumab is approved as a second-line treatment, as well as adjuvant therapy for patients with completely resected melanoma.
Perhaps most promising are results from a combination treatment using both ipilimumab and nivolumab, which the FDA approved in 2015 for previously untreated (first-line) unresectable or metastatic melanoma for patients without a BRAF mutation. In 2016, the FDA expanded the approval to include treating melanoma regardless of mutational status. Patients receiving the combination had an objective response rate of 50%, compared to 40% for nivolumab and 14% for ipilimumab—an increase greater than either drug alone.[v]
Several additional checkpoint inhibitors, and checkpoint inhibitor combinations, are currently in development.
In 2015, another type of immunotherapy—oncolytic virus therapy—was approved for the local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with melanoma that has recurred after initial surgery. Talimogene laherparepvec (T-VEC, trade name Imlygic) is a genetically engineered herpes simplex virus that preferentially targets cancer cells and then replicates within them while also causing the cells to produce the protein GM-CSF, which recruits immune cells and promotes their growth. Eventually the tumor cells burst, releasing tumor-derived antigens, GM-CSF, and viral particles, all of which elicits an anti-tumor immune response. A clinical trial testing T-VEC versus GM-CSF showed the durable response rate was 16% in patients who received at least one dose of T-VEC, and 2% in the GM-CSF arm.[vi]
Despite its ability to target tumor cells and promote an immune response, T-VEC has not been shown to improve overall survival or have an effect on visceral metastases. Ongoing research aims to enhance the effectiveness of oncolytic virus therapy and broaden its applicability.
Cancer vaccines are designed to elicit an immune response against tumor-specific or tumor-associated antigens, encouraging the immune system to attack cancer cells bearing these antigens. Several trials of vaccines, given alone or with other therapies, are currently enrolling patients:
Adjuvants are substances that are either used alone or combined with other immunotherapies to boost the immune response. Some adjuvant immunotherapies use ligands—molecules that bind to proteins such as receptors—to help control the immune response. These ligands can be either stimulating (agonists) or blocking (antagonists).
Another major avenue of immunotherapy for melanoma is adoptive cell therapy. In this approach, T cells are removed from a patient, genetically modified or treated with chemicals to enhance their activity or numbers, and then re-introduced into the patient with the goal of improving the immune system's anti-cancer response.
Monoclonal antibodies are molecules, generated in the lab, that target specific antigens on tumors.
In 1998, the FDA approved the use of the immune molecule interleukin-2 (IL-2) to treat advanced melanoma. This provided the first proof-of-principle that an immune-based treatment could provide durable control of the disease. The immune molecule interferon alpha (IFNα) has also been used alone after surgery or in combination with other agents to treat advanced melanoma.
Go to our Clinical Trial Finder to find clinical trials of immunotherapies for melanoma that are currently enrolling patients.
Since 1982, CRI has dedicated nearly $38 million to fund laboratory and clinical research aimed at unlocking the power of the immune system to fight melanoma. This includes 36 clinical trials conducted through our global clinical trials network, which have enrolled nearly 750 patients with melanoma. See below for other CRI-funded studies that are advancing the understanding and treatment of melanoma.
Sources: National Cancer Institute; National Cancer Institute Physician Data Query (PDQ); American Cancer Society Facts & Figures 2016; GLOBOCAN 2012; NCI Surveillance Epidemiology and End Results (SEER); National Comprehensive Cancer Network (NCCN) Guidelines for Patients; ClinicalTrials.gov; Melanoma Research Foundation; CRI grantee progress reports and other CRI grantee documents
Last updated April 2016
[i] Improved survival with ipilimumab in patients with metastatic melanoma. Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ. N Engl J Med. 2010 Aug 19; 363 (8): 711-23. (PMID: 20525992)
[ii] Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma. Schadendorf D, Hodi FS, Robert C, Weber JS, Margolin K, Hamid O, Patt D, Chen TT, Berman DM, Wolchok JD. J Clin Oncol. 2015 Jun 10; 33 (17): 1889-94. (PMID: 25667295)
[iii] Pembrolizumab versus Ipilimumab in Advanced Melanoma. Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, Larkin J, Lorigan P, Neyns B, Blank CU, Hamid O, Mateus C, Shapira-Frommer R, Kosh M, Zhou H, Ibrahim N, Ebbinghaus S, Ribas A; KEYNOTE-006 investigators. N Engl J Med. 2015 Jun 25; 372 (26): 2521-32. (PMID: 25891173)
[iv] Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Weber JS, D'Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, Hoeller C, Khushalani NI, Miller WH Jr, Lao CD, Linette GP, Thomas L, Lorigan P, Grossmann KF, Hassel JC, Maio M, Sznol M, Ascierto PA, Mohr P, Chmielowski B, Bryce A, Svane IM, Grob JJ, Krackhardt AM, Horak C, Lambert A, Yang AS, Larkin J. Lancet Oncol. 2015 Apr; 16 (4): 375-84. (PMID: 25795410)
[v] Opdivo Prescribing Information. Opdivo U.S. Product Information. Last updated: January 23, 2016. Princeton, NJ: Bristol-Myers Squibb Company.
[vi] Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma. Andtbacka RH, Kaufman HL, Collichio F, Amatruda T, Senzer N, Chesney J, Delman KA, Spitler LE, Puzanov I, Agarwala SS, Milhem M, Cranmer L, Curti B, Lewis K, Ross M, Guthrie T, Linette GP, Daniels GA, Harrington K, Middleton MR, Miller WH Jr, Zager JS, Ye Y, Yao B, Li A, Doleman S, VanderWalde A, Gansert J, Coffin RS. J Clin Oncol. 2015 Sep 1; 33 (25): 2780-8. (PMID: 26014293)
January 31, 2017
December 1, 2016
November 1, 2016
Are you a patient interested in enrolling in a cancer immunotherapy clinical trial? Visit our Clinical Trial Finder page to learn what trials you may be eligible for.
Following a stage III melanoma diagnosis at age 25, Kevin Lankes was treated with the immunotherapy interferon. Now, more than a year cancer-free, and with a finished memoir under his belt, the young writer is looking at life from a different perspective.
Listen in as Dr. Jedd Wolchok discusses the latest immunotherapy research for melanoma in this 45-minute webinar recording.
Watch Now
Subscribe to our e-updates to receive the latest news about melanoma immunotherapy.
A donation to the CRI today will help us to fund groundbreaking scientific research aimed at bringing safe and effective immune-based treatments to patients with melanoma.


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Ogbuebulle Community Development Union
Welcome to Ogbuebulle Community Development Union (OCDU), Alala Oboro, Ikwuano Local Government Area, Abia State, Nigeria
Ogbuebulle is one of the five villages that descended from the great war-lord, Oboro. The others being Amaoba, Ndoro and Umuogwara-Nnono all in Ikwuano LGA, and Ndume in Ibeku in Umuahia LGA. The village still maintains close contact with Abam, its kit and kin in Ohafia LGA also of Abia state.
Their father, Oboro is a brother to Bendi (now Bende). Although, time has continued to diminish the frequency of contact between Oboro and his brother, Bendi, cultural exchanges between Oboro and Abam on the one hand and between the villages mentioned earlier has continued especially major cultural events such as the Ekpe festival which marks the beginning of the new farming season.
Pages of History - Our People, Our Destiny
The Discovery of Iyintaocha Stream
By: Administrator . Written: 23-03-2013
The Ogbuebulle community faced scarcity of water when they lived Close to Oloko village. In those days, they were known for cattle rearing. The famous cattle rearer then was Mr. Iteogu from Obuodo. ...Read more
The Hunting and Killing of Kwura in Ogbu…
By: Administrator . Written: 23-03-2013
During the Second World War, Oboro was invaded by a Hyena that went on rampage killing at will. Many people in far away villages lost their lives to the rampaging Hyena. Ogbuebulle was among. At&nbs...Read more
Ekpirikpe Ogu (War Dance)
By: Administrator . Written: 23-03-2013
Ekpirikpe Ogu is a war dance performed by warriors, for warriors and during epoch making/marking events of valor. Giving the traditional origin of Ogbuebulle people who migrated from Bende, this dan...Read more
Afo Amaghi Onuma
By: Administrator . Written: 23-03-2013
In Ogbuebulle, the new yam festival is christened "Afo-amaghi- onuma". There is a story behind the uniqueness of the name for this celebration in Ogbuebulle village. Historical sources made us to u...Read more
More News from OCDU Branches
Prev Next Page:
Report of OCDU Federated …
By: Mike Egwuibe . Written: 04-03-2013
Introduction The December conference took place on December 25, 2012 at Umuoyi Civic Centre. The Agenda was read out by the President General and was...Read more
A Well-Deserved Rest at H…
By: Mike Egwuibe . Written: 30-03-2012
Another worthy son retires to the vila after sojourn in Lagos. OCDU Lagos wishes him and his wife a well-deserved rest in the serenity of his fat...Read more
OCDU - Enugu: The Servant…
By: Administrator . Written: 23-12-2010
In a keenly contested election, the following have emerged as the executives of OCDU, Enugu branch. Chairman Ikemba Chimbo ...Read more
OCDU - Federated Executi…
By: Administrator . Written: 23-12-2010
In an atmosphere devoid of rancor and discord, members from all branches, both within and abroad, gathered at Umuoyi Civic Centre and spoke with one v...Read more
Mrs. Ukeji Ujah 1988 – 19…
By: Administrator . Written: 06-09-2010
Mrs. Ujah is one of the amazons of OCDU Lagos. Her reign as President commenced even before her formal election. She along with Mrs. Nwanjele Uwaom...Read more
Mazi Igbodiegwu Emma Ebul…
By: Administrator . Written: 06-09-2010
Mazi Igbodiegwu Emma Ebule appears to have read the book of Joel in the Holy Scriptures before seeking to lead the Community. He came with visions. ...Read more
Honouring Past Presidents
By: Administrator . Written: 30-08-2010
The Chairman, members of the high table, special invitees, my predecessors in office, our esteemed Patrons and Patronesses, Ladies and Gentlemen, it...Read more


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Chocolate Spiderweb Treats
Triple Chocolate Brownie Cookies
Hot Fudge Brownie Dessert
Cheerios™ and Trix™ Treat Bars
Mexican Chocolate Crunch Brownies
Crispy Bat Treats
Enjoy these crunchy bars made with chocolate, peanut butter and rice cereals. Perfect Halloween dessert to please a crowd.
You can use other favorite chocolate candy bars to replace peanut butter cup candies, if desired.
© 2016 ®/TM General Mills All Rights Reserved


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Are you looking for Dress in UTAH? Hotfrog showcases more than 50 popular businesses related to Dress in UTAH! Find a specific region or suburb using the left navigation.
- 02/19/2011
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Disney Princess Dresses, Costumes, Fairy Wings, Childrens Princess Dress Up Shop We offer a large variety of little girl dress up costumes so come on in and take a look around Your little princess will lov…
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Professional dress designer Lynette Robinson's formal wear and bridal gallery in Ogden Utah is sure to fit your size
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GownModest WeddingGownsBridesmaid Dresses
Apart from our commitment to a fun, personalized experience, what makes Ypsilon different from other dress stores in Utah is that we specialize in prom dresses
Why Choose Jones Dress Shirts Our customers stay with us long term due to our high level of customer satisfaction, prompt service and quality products
Dress ShirtsMens Dress Shirts
American Fork, UT
We started this boutique with the intent to offer affordable wedding gowns We have many sample dresses available to view and try on We don't sell designer gowns, we operate out of our home, don't hire outs…
GownsDressesWedding DressesWedding Gowns
Eagle Mountain, UT
Offers princess, fairy, dance, and other costumes as well as accessories.
Princess dressDressesTutuTiara
Spanish Fork, UT
Debra Lee Originals is always trying to use American made products and local manufacturing We use American made materials and manufacture our dresses right here in Utah
Christening Dresses
Honeyville, UT
Custom-created gowns and costumes for Theme Weddings, Figure Skaters, Historic Reenactments, Dance Groups and more
syracuse, ut
Brand name Golf Shoes, Free Shipping on every order. Nike Golf, Callaway Golf, FootJoy Golf, and ECCO Golf Shoes
Dress ShoesMens Dress Shoes
Orem, UT
Avenía Bridal is a wedding dress and bridal gown boutique offering designer gowns from Badgley Mischka, Liancarlo, Tara Keely, Rivini, Vineyard, Sposa by St. Pucchi and Junko Yoshioka. Located in Provo, Utah, Avenía also…
GownBridal DressDesigner GownsWedding Dress
Pleasant Grove, UT
Thinktank Toys - Toys, Costumes and More...We have toys as well as a huge selection of costumes for your entertainment and amusement. Our educational toys teach acute thinking skills so that kids can have fun learning. W…
HeadpieceChild CostumeKids CostumesSatin
Saratoga Springs, UT
Fairy Wings and Princess Dress up Clothes, Quality Fairy Wings & Dance Dresses, Disney Dress Up Costumes, Dresses & Accessories. Favorite Costumes for your Little Princess
Kaysville, UT
Kathleen's Bridal has modest wedding dresses, prom dresses, bridesmaid dresses, lds temple dresses, lds baptism dresses and more. Great Rates! 888-547-0061
Flower Girl DressModest WeddingMother Of The BrideBridesmaid
Murray, UT
Fantasy Bridal, located in Salt Lake City, Utah, provides bridal gowns, accessories, and bride's maids dresses in contemporary, modest, and destination styles
GownBridesmaidWedding DressGowns
Layton, UT
Andee Lew LLC was founded in 2007 by designer Lindsay Kelly. The company has quickly grown due to a high demand for basic shirts for infants, toddlers, and kids. We love making great high quality clothing for children a…
Springville, UT
With over eighteen years experience in the design, production, and sales markets we can offer complete service from concept to finished products. This extensive experience in product development of women's, men's and chi…
Called To Surf will keep in stock men's and women's swimwear for the entire winter. So if you're headed to Hawaii, Disneyland, or just want to grab some gear for Christmas that you can use next summer-we are your one-sto…
At ScrapbookSteals.com you'll find one hot scrapbooking product every day at 50-80% off until it sells out. It's not just a deal, it's a steal! A ScrapbookSteal
St George, UT
Southern Utah's best wedding and event coordinator for over 11 years. We offer wedding planning and coordination for St. George, Ivins, Hurricane, Mesquite, Springdale, and Cedar City. Let us create a wedding Uniquely Yo…
Wedding Planning And CoordinationFormal WearBrides
West Jordan, Ut
At Dani's Bridal Works our commitment to service has helped keep us in business for over a decade We know that your wedding day can be stressful that's why at Dani's, we go the extra mile to help you find the go…
GownsFlower GirlsBridesmaidsDresses
Studio, UT
OpieFoto specializes in wedding photography and portrait photography in salt lake city and surrounding areas in Utah We use candid, artistic, photo journalistic, and traditional styles to create a unique mix of…
The Sewing Parlour offers classes, machines, irons, and other equipment to work on your projects. Also has a selection of patterns, interfacing, thread and other notions for sale
bluffdale, ut
Find the Latest Performance Parts from COBB Tuning, Invidia, Grimmspeed, and Kartboy Intakes, Brakes, Exhausts, Turbos and Motors at RallySportDirect.com
For years Conselle has been the Image Consulting industry leader. Conselle can help you remake your image, or train you to be a world class image consultant
wardrobe planningPersonal Image Consultant Wardrobe ConsultingWardrobe Consultant
Saint George, UT
Hotfrog US provides information regarding Sherry B Originals in Saint George UT. Sherry B Originals is located at 929 W Sunset Blvd and provides Tailor services. Contact them on (435) 491-0480 or by visiting their websit…
ClothesDoll clothes
Tooele, UT
Welcome to P Sweet Boutique. We carry a wide selection of beautiful unique and affordable headbands for your precious little one! Our headbands are all things lacy, vintage, and shabby chic for every
Ogden, UT
Our solitary location in the foothills below Ogden canyon not only gives us a panoramic view of the mountains, but quite seclusion away from city traffic and noise
Salt Lake City's Finest Bridal Boutique. High fashion designer wedding gowns from traditional to trendy, simple to elaborate, and customized to make YOU unique on your wedding day
GownFlowergirlBridesmaidWedding Dress
riverdale, UT
We provide a full selection of gowns and accessories in every style imaginable We are a full service bridal shop with all the bells and whistles We take bridal and social occasion wear very seriously with a …
Bridal & Formalwear
Bravura Boutique carries clothing for women from size zero to 3x. We are commited that women feel confident in our clothing, It Fits
Moab, UT
Our knit rayon scarves are available in 50 now
ResortwearRayonBeach WearScarf
Sandy, UT
Doll Angels "Learn To Create Dolls For Your Angels" by Lynn Frear
PantsChildren's Clothing
Signature Products Group - SPG, Automotive and Outdoor Products and Accessories
Slc, UT
Modern Vintage Boutique is an online women's clothing boutique offering stylish clothes at affordable prices
Maxi DressesDressesWoman's ApparelLeggings
The Official Website and Online Shop for Zuriick. Free domestic shipping on orders of $100.00 or more... always
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About CUHK Library Digital Initiative
With the mission to preserve valuable heritage materials, to promote resource-sharing and to facilitate academic research, The Chinese University of Hong Kong Library (CUHK Library) has long been devoted to develop digitization projects and to provide convenient online access. Since 1995, many print and audio-visual materials, including Chinese rare books, books published in China and Hong Kong during the Minguo period (1911 – 1949), journals, newspapers, manuscripts, open reel tapes, audio/video cassettes, etc. have been converted and over 20 projects have been launched.
CUHK Library also collaborates with other libraries to foster resource-sharing. Since 2007, CUHK Library has participated in China-US Million Book Project (lately, renamed to CADAL) by contributing over 3,000 Western books published before 1923. Over 650,000 volumes of Chinese rare books and books published during the Minguo period are also available online.


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Easy Songs For The Beginning Mezzo-Soprano/Alto
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Vocal, Piano Accompaniment - Difficulty: easy-medium
Vocal Collection. Vocal Standards and Play Along. Softcover Audio Online. With vocal melody, lyrics, piano accompaniment and introductory text. 72 pages. Published by G. Schirmer (HL.50483757).
Item Number: HL.50483757
ISBN 0634019708. 9x12 inches.
This series was designed to supplement traditional vocal instruction and works perfectly as preparatory literature for The First Book of Solos and The First Book of Solos Part II. Each piece is in English and has a limited vocal range as well as a piano accompaniment that is playable by a student pianist. The pieces include art songs, folksongs, humorous songs, and suitable vintage popular songs and are all appropriate for contest solos. The accompanying CD includes professionally-recorded accompaniments.


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Mars Orbiter Mission trajectory
Filed under Mars Orbiter Mission (MOM), mission status, trajectory diagrams
Original image data dated on or about December 4, 2013.
Read ISRO's image terms of image reuse here.
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