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You just got a new camera ...
It's a familiar story: you get a brand new digital camera, and you can't wait to begin taking the best photos of your life. But then, you run smack into the fact that your camera is very confusing and complicated. So much so, that it often gets in the way of you being the skilled (and happy) photographer you dream of being.
You've been photographing for a while ...
You know your camera is capable of so much more. You know a lot about photography and you know that there is a lot left you would love to learn. No matter where you are in your skill level or what you'd love to learn next, we can help you find the best path for you to dramatically improve your photography and take it to the next level.
Helping people to become better photographers, one picture at a time ...
We've created a series of courses, classes and hands-on workshops that, together, make a comprehensive learning path for you to follow, with multiple options. And you won't be alone. Like the Beatles, we wanna hold your hand.
Photography The Basics
First, we help you figure out the camera. Menus and all. Taking the frustration out of learning the nuts-and-bolts. More ...
NEW Now also as a webinar course
Beyond The Basics
Your next step on the journey is to learn the artistic aspects of photography: composition and design. More ...
Receive assignments twice a month, and attend a webinar once a month in which we'll critique a member's photo. More ...
Inner Circle Sessions
In these invitation-only shoots, you'll plumb your creative depths and soar to new heights, creating awesome images.
Hands-On Workshops
Hone both photography and editing skills. Our hands-on workshops cover a variety of topics. More ...
Our most popular course
6 weeks course on Thursdays.
Get the most from your camera. We'll show you how, step by step.
With patience and kindness.
NEW: Weekend Intensive
Not ready for a full on 6 week course? Maybe The Basics Lite is for you..
Check out the details.
Next course:
Dip your toes into the Digital Photography pool. Our free two-hour class will answer many basic questions. A $99 value. And it's free.
Next class:
Professional Certification
Many, once they've polished up the basics and mastered the more advanced, want to go pro. We'll help.
Running Your Photography Business
Making the leap from artist to businessperson presents unique challenges. We'll help you work though them. More ...
Intro to Digital Photography
We run this class every now and then, when we have enough interest. Two quick hours to give you a leg up. More ...
Sign up for our FREE bi-monthly newsletter or download our FREE Photography Quick Start kit on the Freebie page. Consisting of 4 eBooks, the FREE kit answers questions on what camera to purchase, what lens to consider, whether or not you'll need a tripod and how to dramatically improve your photography.
All for FREE.
We want to make it easy for everyone to enjoy learning in a positive and supportive setting. Our photography classes are very informal, and it helps if you have a sense of humor. We tell students if they get frustrated to stop doing what they are doing, because most likely they are missing something small. Photography is supposed to be an exciting, positive and enjoyable pastime and we try to make learning fun and hands-on.
If you sign up for a course and miss a class, we make it easy for you to make up. You can come in and take part in any of the upcoming courses, and all we ask is that you let us know to expect you.
Our clients love photography and enjoy our learning environment.
But don't just believe us, read on to see what they have to say:
C1M Academy
Let the truth be told
Student Testimonials
Walter is a GREAT teacher. I am so far advanced from when I first walked into class 6 snowy weeks ago. Thank you for helping me to enjoy my hobby more than I ever thought possible!
Bob, Mont Vernon, NH
I had a lot of fun in Photography the Basics. I got out of the course exactly what I wanted to get out of the course. I knew what f-stops were and I knew what shutter speeds were, but to be able to use them together to actually make a picture come together was really cool. Walter has a terrific sense of humor, and he has a great way of explaining things.
Kristen, Alstead, NH
I got everything I wanted to out of Photography the Basics and more. I've had my camera forever, and I wish I'd had this course when I first got the camera. It would have saved me a lot of frustration. Everything from the camera manual that I couldn't understand was taught in this course in a very comprehensive manner. The best part was the assignments - getting to go home and put everything I'd learned to work was fun
Heather, Brookline, NH
I really enjoyed Photography the Basics. When I bought the camera, I bought the book for dummies to go with it, and I couldn't get anything out of that book at all. I need a visual type of learning, and that's what Walter gives. He's a really good teacher.
Tamara, Manchester, NH
Photography the Basics was interesting for me. I've been behind the camera for a really long time, and I've learned a lot through trial and error, but it's a lot easier to get the specific shot I want now without having to work as hard at it, which is great.
Sarah, Dublin, NH
After Photography the Basics, I'm definitely more comfortable with my camera settings than I was. I think I read the mini manual that came with my camera 40 times and just couldn't retain it, but now I feel like I can do this and I'm excited to get out there and practice. I feel like I have such a grip on it now.
Lisa, Londonderry, NH
I'd only had point and shoot cameras, so before I started Photography the Basics I could barely even turn on my camera. I was a little bit afraid because I was such a novice with using a digital camera, but Walter does a great job of explaining things and using different methods to get his point across. I learned a great deal and had a lot of fun.
Judy, Litchfield, NH
I've had my camera for five years, and I finally learned to use the manual part of it, which I wanted to do. I think Photography the Basics is an excellent course.
Ben, Lowell, MA
Amazing must-take class for those stuck in auto-mode! Walter helps demystify the digital camera with easy to follow reading materials, hands-on in-class examples, and homework assignments. I now have the confidence to stop shooting in dummy-mode. THANK YOU!
Michelle, Brookline, NH
I feel that your basic photography class is priceless. I liked the way you outlined your photography book, as well as working with the students individually. I would recommend this class to anyone interested in photography.
Cathy, New Ipswich, NH
I enjoyed the first course so much I signed up for the next one! I got out of it exactly what I was hoping to get out of it - to feel more comfortable with my camera - to be able to get it out of auto.
Patty, Hudson, NH
I am so glad I took this class, it was an awesome experience!I took a year of photography school way back in the days of film, and I truly believe I learned more in this 6 week course then I did that whole year! I can now shoot confidently in manual mode. Walter's ability to explain things in a way that's easily understood, using real examples and situations, and, of course, his great sense of humor, is the difference between us learning the material versus memorizing it.
Kerri, Merrimack, NH
My goal for taking this class was to successfully be able to take my camera off auto setting and to use the camera to its full potential. I am pleased to say that after 5 weeks, I am taking pictures on the manual setting and have been very pleased with the photos I have taken. The class is fun, light-hearted and a tremendous learning experience. I would highly recommend this course to anyone who has any interest in photography.
Kristy, Brookline, NH
Taking the Photography The Basics class has allowed me to understand the camera and functions to a new level. After 6 weeks, I am taking better photos using the knowledge gained in this class. I recommend the class to anyone with a current camera.
Sandy, Milford, NH
I am glad I took this course. It has been very helpful in learning more about my camera and about the art of taking pictures. You have made this a pleasant learning experience with your wealth of knowledge and clear descriptions. I hope to follow up with a more advanced class in the
Lynn, Nashua, NH
I feel like I have learned so much from this course. You made it fun and easy to understand.
Jill, Nashua, NH
Thank you for the wonderful class! It was exactly what I was looking for. I wanted to get away from "auto mode" and move towards using the functions of my camera; your class offered all that and more! The class is very helpful and you have a wonderful way of teaching!
Belinda, Hudson, NH
You have a great attitude, approach and the patience for teaching. People can relax and not be embarrassed as they learn... and you keep it interesting!
Jay, Manchester, NH
In 2 nights of the Photography The Basics course, I learned more than at an 8 weeks course at a photography school in Boston. Plus, parking at C1M is way easier.
Renee, Pepperell, MA
I am now in my second class at C1M studio. Walter is an amazing instructor. He is able to communicate to students at all levels. I am looking forward to gaining a wealth of knowledge guided by Walter... I don't look at this as a class but a journey with endless possibilities.
Linda, Manchester, NH
I really enjoyed taking the Photography Basics course. I went from only being able to use my Digital SLR in program mode, to now being able to operate it fully in manual mode as I learned what each feature of my camera was capable of doing. In six short weeks, I've learned how to creatively use my camera settings, along with basic photography techniques like composition and lighting, to make my pictures come alive! I started out wanting to learn a few things and ended up learning so much more! The class setting was very comfortable and you were a great teacher who was always willing to answer any questions. I enjoyed your sense of humor and all the tips and tricks that you taught us. I'm really excited to learn more and expand my creativity and can't wait to take the intermediate class! Thanks again!
Karen, Milford, NH
I enjoy your class and I'm getting a lot from it. I've tried other photography courses but they were not as educational and inspiring. They were more about how to enhance your work after the photo was done, not into the functions of the camera and how to control those functions. You are a good teacher.
Mark, Manchester, NH
I have truly enjoyed every minute of both courses and gained so much knowledge and experience. And I have you to thank for this. Your teaching style and personality are fantastic and you make the student feel comfortable at every point. I have always felt comfortable to ask anything, never feeling that you would be bothered by a question or think it's stupid. Even at the close of the intermediate course, you have me still wanting for more knowledge.
Anthony, Derry, NH
I have a new camera with many features and functions. The photography class showed me what all the camera functions can do for me, and how to use them effectively. I have gained a fundamental knowledge about photography that will allow me to capture what I need and to be a better photographer. The workshop was informative as well as fun. I especially liked the hands-on experience of taking pictures with the information we just learned... I would recommend this workshop to anyone looking for a better understanding of their camera, as well as the basics of photography!
Missy, Concord, NH
I wanted to learn more about how to use my camera and your photography class helped me understand features and functions that were a mystery before. We ventured into camera settings that I did not know were there before. I have gained the confidence to change settings and experiment without fear. This workshop was exactly what I was looking for in a very hospitable setting and at a great price.
Kristina, Nashua, NH
I recently attended one of the C1M photography classes and wanted to let you know what a wonderful job you did. This workshop allowed me to gain the confidence I needed to experiment more with my camera as well as gain a better understanding of my camera. I am no longer afraid to go into different camera settings and take pictures. It truly was a hands-on class that I needed. I also greatly appreciated your patience with answering all my questions. I definitely learned more than I expected and had a lot of fun. I highly recommend the C1M classes and workshops to all. Thanks again for all your great advice.
Lyn, Nashua, NH
I really enjoyed learning about taking better photographs, and you did an outstanding job of teaching. I can certainly apply your methods in my daily work, and am already taking better studio photos because of your training. Additionally, you have taken some incredible photography and have a "to die for" studio and classroom setup.
Jim, Portsmouth, NH
When point and click just wasn't doing it for me anymore I invested in a digital SLR...it did not take long for me to realize I was using only a fraction of its potential. Then I found C1M. Walter has opened doors I did not know existed with my SLR. I am enrolled in my 3rd course with him and learn something new each class. Walter's teaching style is perfect for those of us who may be intimidated and need time to experiment and ask questions until we get it! Thanks for being such a wonderful photography professor!
Lisa, Nashua, NH
I have a passion for capturing moments - whether they be in nature, around my house or just a perfect moment that I want to save forever. Photography does that for me. Walter Schnecker provided me with an outstanding class to teach me what photography is all about and how to capture those special moments with ease. I loved this class and am grateful for what I have learned.
Amelia, Brookline, NH
You offer something very few do in NH (classes) and do it so well. People enjoy your classes and teaching style and they get hooked. Trust me ... I am talking from experience. :)
Tony, Londonderry, NH
I just finished the beginner's course. I have to say that Walter took the mystery out of everything from f-stops to depth-of-field. I am now shooting all of my photos fully manual and in RAW mode. If you don't know what that means but want to, sign up. It will be worth your time.
Bob, Greenfield, NH
This is exciting!! Thank you! I'm very glad I'm taking this class. You are a wealth of information and you have a great sense of humor.
Cathleen, New Boston, NH
I've learned so much during the first couple of classes in the basics that I really look forward to the classes still to come. Thank you for everything :)
Linda, Manchester, NH
Fantastic photography class! I really looked forward to Thursday nights and will miss being there next week! It was well worth the hour drive over, and I am looking forward to attending the intermediate class in the fall. I have begun the journey to really explore an interest that has been on hold for some time. Your demonstrations helped solidify understanding of the more difficult concepts, and the relaxed atmosphere of your class made asking questions a breeze.
Diane, Windham, NH
After receiving a new SLR camera, I realized that I needed to learn how to use it! I registered for the Basics Course and got more than just the basics. I learned all about the camera and more. I especially loved the creative piece to the course and the weekly homework assignments really reinforced the class work. It was fun looking at everyone else's work too. Walter's teaching style is very relaxed and his sense of humor a delight. It was something I looked forward to every week. I will definitely be registering for the Intermediate class!
Kelly, Windham, NH
The C1M photography classes and workshops are very informative, fun and a great value. I learned a lot about photography and how to get great pictures. At the beginning of the workshops I could hardly use my camera. Now I know all the available functions and how to use them.
Lucia, Nashua, NH
I signed up for the Basics course because I wanted to be able to use more features of my camera instead of the automatic mode. This course is perfect for people who are just starting and trying to figure out how to use their camera, and it's super laid-back. It's a lot more fun to take pictures now, because I can actually do what I want with my camera instead of getting frustrated!
Avery, Brookline, NH
I think Photography The Basics is a great course. I definitely liked how each week focused on a certain thing. I was really impressed by the the amount of things that we covered - just the different aspects of the aperture and the shutter, and then one week was lighting. I didn't know we would go to that extent and cover as much as we did in a 6-week course. I would definitely recommend it, and I'm also going to take the intermediate level course.
Jennifer, Dracut, MA
I would definitely recommend the Basics course. I think it's a great starting point for anybody that wants to learn about using a digital camera or an SLR camera, and a great starting point just to learn how to take pictures. After every class, I was looking forward to taking pictures. Now I'm not afraid to go out of the automatic mode, and I loved really learning and using what I now know to create great photos.
Rachel, Raymond, NH
I've been doing photography for many, many years, and I'd photographed weddings and portraits in the past. I haven't for a few years, and I wanted to get back into it. I decided to take the basic course, and I'm very happy that I did. I learned a few new things. I was reminded of some things that I've forgotten over the years, and it just reignited my desire to go take great photographs again. The course is very casual and comfortable, but the assignments were challenging enough to make me think and to really apply what I'd learned in each class. It's well worth the time and effort and I actually plan to take the intermediate course in the very near future.
Steve, Manchester, NH
I took the Basics class just to learn more about digital photography. I shot with a Hasselblad for the last 20 years. I've been shooting with a digital camera for the last 4 years now, but it's still kind of new to me even though I've shot a lot. I wanted to start fresh and learn as much about digital photography as I can. My ultimate goal is to be able to do museum-quality photography. The course was very creative, and there was some good humor built into it, too.
Vincent, Amherst, NH
The Basics is a great course. There's lots of good info and having us put all the components of manual setting photography together was beneficial. I am definitely interested in proceeding to the next series of instructional courses.
Tom, Milford, NH
Photography The Basics is a great fundamentals course. I highly recommend this course if you bought a digital camera and are still a bit confused about all those settings and numbers. Thanks Walter and we'll see you in the next class!
Dennis, Manchester, NH
When I first started the Basics class, I never thought I'd be able to use the camera in manual mode within four weeks. Trust me - you will be surprised. I honestly can't believe the amount I was able to learn in such a short time! Walter is an awesome teacher. I can't recommend C1M enough and I'm looking forward to Photo Elite and the intermediate course in April.
Brandon, Nashua, NH
Never have I taken a course that I have enjoyed more. Walter is a true Master of photography and took the mystery out of taking pictures I am proud of.
Kelli, Northwood, NH
I just finished Walter's basic photography course. The setting is great and very laid back. I learned a great deal and cannot wait to start his intermediate class. Walter has a very nice teaching style and a lot of good humor to go with it!
Cresca, Hancock, NH
I completed the Basic Class and enjoyed it so much I just started the Beyond Basics Class. I used to use "auto" mode all the time, but after the Basic Class I only shoot in "manual" mode. This has opened a whole new world and I now feel like I am getting my money's worth from my digital SLR. I read books on photography, but they never conveyed the information I needed to get out of "auto" mode and use "Manual" mode.
The Basic Class is a great investment for anyone who wants to take better photographs but is trapped in "Auto" mode.
Glenn, Milford, NH
The digital age threw me off after years of shooting film. Thanks to Walter's easy going ways, great sense of humor and willingness to share his talents, I am thrilled to be back behind the viewfinder and in charge of my camera once again.
June, Hollis, NH
I have learned more in 4 weeks than I thought possible. I understand my camera so much more! Walter is an amazing instructor.
Kelly, Milford, NH
Just finished the Basic Photography Class and I would highly recommend taking this class if you want to learn how to use your camera. Walter is an awesome teacher and really takes the time to answer any questions that the students ask. I am looking forward to taking other classes that will improve my skills and creativity.
Leslie, Nashua, NH
C1M Photo Academy is the place to go if you want to learn the techniques of taking better photographs and Walter is the teacher who shares his knowledge and makes it fun at the same time. I'm so glad I've attended his classes. The understanding of my camera makes the world of difference in the photos I take. The [Facebook] group and the photo challenge he started, helps you continue to be creative with what you've learned and be part of a community that learns together, even when the classes are done. Thanks Walter!
Libby, Nashua, NH
I am so thankful to Walter for teaching the Basics Course and for his availability. His knowledge and teaching style is just what I needed to put everything together. I've taken other photography classes and did not learn as much or understand as much as I have after taking his Basics course. I am looking forward to taking the Intermediate Course and to continued improvement of my skills. Thank you Walter for your encouragement and skill.
Lynne, Manchester, NH
For anyone looking to get out of automatic and into manual mode, Walter's classes are fantastic! His technical knowledge combined with his sense of humor make for an enjoyable class experience.
Mary Joy, Hudson, NH
Great class. Walter's teaching style is exactly what I need to learn and to stay focused. He is always happy to answer any questions we may have and I have already noticed big changes in my pictures. I'm excited each week to go to class and see what else I can learn.
Melissa, Milford, NH
Thank you for your dedication to Photography the Basics. Your enthusiasm for photography, and for teaching, came through loud and clear in each class. The investment in [the Canon EOS 70D] is a big one, and I can say with confidence that I can better operate the camera, and now know how to correct mistakes, but better yet, set it to capture the image that I desire.
Stacey, Manchester, NH
I enjoyed the class and look forward to the intermediate class. I have learned to live in manual mode and feel comfortable there now. I was very impressed with your magical cart of tricks for teaching the more complicated areas of photography. The ISO demonstration was brilliant.
George, Brookline, NH
Great class to truly understand shooting in Manual, the "whys" and "hows"! Fun, hands-on learning.
Colette, Merrimack, NH
Photography can seem complicated. You need to understand how your camera works, what the numbers on the lens mean, what is the difference between aperture and shutter mode, how to compose a shot. If you're looking for answers then check out C1M's courses. Walter takes you through it all, plus more. I highly recommend his courses. He takes away that overwhelmed feeling you can get when trying to learn photography on your own.
Jean, Strafford, NH
I have taken the Basics class and I am currently enrolled in Beyond the Basics. I have learned so much from these classes and it is really starting to show in my photos. Walter is the absolute best photography teacher I have ever had.
Lauren, Amherst, NH
I am so thrilled with what I have learned and the confidence that I have gained by taking your classes. I am looking forward to taking it to the next step.
Deb, Londonderry, NH
Walter is an excellent teacher. I found the Basics course so informative that I am taking the intermediate course, Beyond the Basics. Walter is a gifted photographer with a style of teaching that is encouraging and laid back. His sense of humor keeps things in perspective. The C1M studio and classroom are modern and state of the art. I'm learning and being challenged and enjoying the whole experience!
Kathleen, Manchester, NH
I thoroughly enjoyed the Basics course. The material was well laid out and informative. I think that the approach of the course focusing on segmented instruction followed up by a practice assignment is a good one that helps connect the learning.
Jay, Hollis, NH
I got out of Photography the Basics exactly what was promised. Thanks for all of the information during the course. .I plan on attending the next Intermediate course.
Mark, Peterborough, NH
I just finished my first course tonight and I can't believe I waited so long to take it! If you're ready to take next steps with your camera the Basics course is definitely recommended. Also, there are always cookies (and water!)
Jennifer, Nashua, NH
Walter takes you step by step to learn how to use your camera. You start in Auto and at the end your shooting in Manual, understanding what you did to get that picture or what you have to do to improve it. Thanks Walter. Looking forward to the next step moving forward in Photography.
John, Hooksett, NH
Simply put, Walter is superb and the Basics Class has something for everyone (novice to experienced). I am definitely looking forward to continue my education. If in doubt, visit C1M during a free "Academy Drop-In" and see for yourself.
Christoph, Nashua, NH
The course was very valuable. I got my camera a couple of months before the course, and just left it on automatic. Four weeks into the course, I went on vacation, and I had my camera on manual mode the entire time. I felt good about that, especially since lighting conditions where I was are different than here. Some stuff just clicked, and I was able to work with the lighting conditions and still get the shots I wanted.
Barry, Manchester, NH
I was a YouTube learner when I first came to this class. I would go do photo shoots but I always shot in RAW, because I knew that I could go back in on my computer and fix things. Now I'm shooting in manual. Walter has taught me a lot, and I think he's one of the best teachers I've ever had. He makes photography exciting. He makes me want to learn more.
Whitney, Merrimack, NH
I got a lot out of the class. I've had my camera for eight years, and now I'm using the settings on it that I never knew how to use before. My pictures are coming out much better already.
Lori, Hollis, NH
"Shutter" and "aperture" were always these things that seemed like another language, but I feel like I have an understanding of those now, plus ISO and whitebalance, which were things I was not even anticipating. I definitely feel like I learned a lot.
Patti, Milford, NH
I'm not afraid of my camera anymore, so that's what makes me happy. Before I would turn it on, shoot in automatic, and turn it off. That was it. I would never play with the buttons, but now I know what they do, and it's just amazing. I thank Walter for giving me the confidence.
Diane, Milford, NH
I got this camera about a year ago, and I spent almost all year using just automatic - with some pretty decent results, but also some times where all my shots came out lousy. I blamed it on the light, but it wasn't so much the light as it was that I didn't have any creative ability to make changes, so I couldn't adapt to the lighting conditions. Now I feel so much more in control. I can read the meter and know I have a good exposure, or I can change my settings to get a good exposure.
Carl, Brookline, NH
Photography was intimidating before, but now it's not. I used to look around and see things I wished I could take pictures of. Now I see things I can take pictures of.
Jen, Bedford, NH
I've had my camera for about six years, and it makes me sad when I think about how many pictures I've taken and said, "Aw, I wish that had come out better." Now, though, I'm so excited. I felt that way every week of the course. Everything just makes so much more sense now. It's awesome. It was so great. I really want to take the intermediate class.
Jess, Milford, NH
After the six week course, I feel like I never want to take a photo in automatic again. Getting into manual mode is a great feeling, and I think you probably wouldn't get there just trying to learn from videos on YouTube. My camera is now working for me. It was not before. Now I can capture good pictures and print them happily.
Mohan, Nashua, NH
I got my camera just before the course started, and I tried taking photos without knowing anything about it. The pictures didn't come out well, or at all - in some cases they were just black. I did a little research on my own, but nothing made sense yet. Now I can go into my settings and realize, oh, I need more light, or I can change my settings. I feel a lot more comfortable with my camera now.
Janie, Merrimack, NH
Coming into the class, I didn't really know how to use the camera and I also didn't understand a lot of what you can do to get the right feel in a picture. The class was great, because it taught me not only how to use my camera, but how to play with the settings to get different effects that make for some really interesting pictures. I didn't know how to do that, and now, coming out of the course, I have a better idea of what to manipulate to get the image I'm looking for.
Sonja, Amherst, NH
I've had my camera for six years. I'd say about 95% of the photos I took were taken outside on automatic, and they came out well. But I'd say 70% of the photos I took inside were yellow or other interesting colors. Now, over the last few weeks (as long as my subjects don't talk back or move) I get really good pictures, and that never happened before.
Tara, Nashua, NH
I've been taking photographs a long time, but the Basics course forced me to go out and do the assignments. No matter how simple the assignment was, I wanted to make it look good, too, so it pushed me to get out of Aperture Priority, which is the only setting I used before.
Paul, Temple, NH
I've wanted to learn more about my camera for a while, but I'd never taken the time. I'm just always too busy, but taking Photography the Basics gave me the push I needed. I'm happy that maybe I'll have a hobby now.
Lauren, Epping, NH
I think Photography the Basics made me realize how much more I could do with my camera than I knew - what I want to do, not just what it tells me to do. This weekend I was at a soccer game in the rain, and I shot the whole thing in manual mode. I would never have been able to do that before.
Yvonne, Pittsfield, NH
Years ago when I was shooting with a 35mm camera, I felt like I knew a fair amount. When digital cameras came along, I kind of fell into using a point and shoot camera, and a lot of times just using intelligent auto mode. Photography the Basics really brought home the fact that I've been limiting my capabilities with the camera that I had. Now I have a good foundation, and I know what camera I want to get to explore photography more fully.
Scott, Dunbarton, NH
I was getting very frustrated with the auto setting, where I knew there was a good picture there, but my camera would refuse to take it. Now that I've taken Photography the Basics, I can make my camera do what I want it to do, instead of it telling me whether it wants to do it or not. I know how to adjust my settings to where I can say, "You know what? I'm going to take that picture, and it's going to be good."
Dani, Milford, NH
I think Photography the Basics helped to give me a foundation I can build on. I'm super busy with my kids and I've wanted to do this for a long time, and now I have a good foundation so I can work on improving my photography at my own speed.
Danielle, Chester, NH
In Photography the Basics, I finally took my camera off auto. I enjoyed just learning where all the buttons are and what they do.
Jodi, Strafford, NH
It's been many years that I've wanted to know how to actually set up a picture. After Photography the Basics, I think I have a start, because I learned how to use the manual settings on my camera rather than just the auto.
Penny, Strafford, NH
Before I was part of Photography the Basics, I thought I knew a lot about how to take the pictures, how to zoom in and zoom out and how to focus the lens, but I didn't know what all the controls meant. I knew there were terms like shutter speed, ISO, and aperture, but I didn't know what they did. Now I do, and now I can actually play with my camera. Because I understand my camera more, I can think more about how I'm going to take a picture.
Darlyn, Derry, NH
Taking Photography the Basics has made me hunger for more education about my camera. I'm not as afraid of all those buttons and everything it does.
Tracy, Northwood, NH
I'm happy to be in manual mode. I feel like just a few days ago, I had an "aha" moment, when I was trying to take a picture and I knew exactly what button to push to make the picture come out right. It was like everything clicked.
Dierdre, Pepperell, MA
I'm about 97% less scared of my camera after taking Photography the Basics. I feel like I kind of laid the groundwork of information on it. I've had my camera for about three years, but I didn't use it much. Now I can just try to practice and get better. I wish I'd taken the course before.
Sarah, Concord, NH
I'd been playing around with my camera in manual before I took Photography the Basics, but I didn't really understand it. I didn't touch ISO at all. I didn't really know how to get the aperture and the shutter speed to work together. I felt like I was fighting it all the time, but I've seen a huge difference since taking this course. Even looking back at the photos I took the first week, my photos look so much better now.
Remington, Pepperell, MA
Taking Photography the Basics allowed to finally get out of auto mode. I can do things manually and get good pictures. I can understand what I'm doing.
Cindy, West Groton, MA
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There's some code that relies on the fact that #ifndef MOZ_ACCESSIBILITY_ATK is the same as being on Windows. This is not the fact anymore...
Created attachment 241967 [details] [diff] [review]
Patch for caret code (checked in)
I'll keep this bug open for other instances where we have to make code XP_WIN-only (I don't want to do a mass-change before I know what the change in behavior would be).
Here's a fix to only enable some caret notification code on windows, and let ATK/mac share the other code.
Comment on attachment 241967 [details] [diff] [review]
Patch for caret code (checked in)
I've checked this in. I'll keep this bug open in case there will be other patches where we'll have to remove ATK #ifndefs to XP_WIN
I took a look, and there are no more places where this pattern occurs. There still are platform ifdefs in the base code but they all seem sensible and they don't imply a platform by negation.

subset: commoncrawl


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Daily Archives: 2012 November 1
When posters went to war
The students in Dr. Kirsten Olds' course Art History 4803 "Cultural Responses to War in the 20th Century" this semester have been working with Marc Carlson and the staff at Special Collections to mount an exhibition in the reading room … Continue reading
Posted in Exhibits, News Tagged exhibit, Great War, posters, propogranda, War, World War I, World War One, WWI Leave a comment


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Arturo Sandoval
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Customer Reviews:
Easton Stealth II Comp Hockey Jock Short Sr
Comments: For me,It doesn't even feel like I have it on. It doesn't interfere my motion at all. I would recommend them to my friends for sure
From: Tommy, CA
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Coping with People's Inflation Perceptions during a Currency Changeover
The discrepancy between popular impressions of how the 2002 changeover to the euro affected prices and its actual impact is perhaps the most surprising consequence of the single currency's introduction. Following the changeover, perceived inflation rose significantly and returned to its prechangeover level only several months later. This paper argues that people's inflation misperceptions could have been avoided. Using principles of crisis communication, we identify the mistakes made and present policy recommendations for future changeovers
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|24 pages
|Date of creation:
|Nov 2007
|Date of revision:
|Nov 2007
|Contact details of provider:
| Postal: Grabengasse 14, D-69117 Heidelberg
Phone: +49-6221-54 2905
Fax: +49-6221-54 2914
Web page: http://www.awi.uni-heidelberg.de/
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Manfred Fluch & Helmut Stix, 2005. "Perceived Inflation in Austria – Extent, Explanations, Effects," Monetary Policy & the Economy, Oesterreichische Nationalbank (Austrian Central Bank), issue 3, pages 22-47.
- Thomas A. Eife, 2006. "Price setting behaviour and price setting regulations at the euro changeover," Bank of Estonia Working Papers 2006-06, Bank of Estonia, revised 12 Oct 2006.
- Wunder, Christoph & Schwarze, Johannes & Krug, Gerhard & Herzog, Bodo, 2006.
"Welfare Effects of the Euro Cash Changeover,"
IZA Discussion Papers
2508, Institute for the Study of Labor (IZA).
- Wunder, Christoph & Schwarze, Johannes & Krug, Gerhard & Herzog, Bodo, 2008. "Welfare effects of the euro cash changeover," European Journal of Political Economy, Elsevier, vol. 24(3), pages 571-586, September.
- Christoph Wunder & Johannes Schwarze & Gerhard Krug & Bodo Herzog, 2006. "Welfare Effects of the Euro Cash Changeover," Discussion Papers of DIW Berlin 646, DIW Berlin, German Institute for Economic Research.
- Ehrmann, Michael, 2006. "Rational inattention, inflation developments and perceptions after the euro cash changeover," Working Paper Series 0588, European Central Bank.
- Giovanni Mastrobuoni & Wioletta Dziuda, 2005.
"The Euro Changeover and its Effects on Price Transparency and Inflation,"
Carlo Alberto Notebooks
26, Collegio Carlo Alberto, revised 2006.
- Wioletta Dziuda & Giovanni Mastrobuoni, 2009. "The Euro Changeover and Its Effects on Price Transparency and Inflation," Journal of Money, Credit and Banking, Blackwell Publishing, vol. 41(1), pages 101-129, 02.
- Amos Tversky & Daniel Kahneman, 1979.
"Prospect Theory: An Analysis of Decision under Risk,"
Levine's Working Paper Archive
7656, David K. Levine.
- Kahneman, Daniel & Tversky, Amos, 1979. "Prospect Theory: An Analysis of Decision under Risk," Econometrica, Econometric Society, vol. 47(2), pages 263-291, March.
- Luc Aucremanne & Marianne Collin & Thomas Stragier, 2007. "Assessing the Gap between Observed and Perceived Inflation in the Euro Area : Is the Credibility of the HICP at Stake ?," Working Paper Research 112, National Bank of Belgium.
- Eife, Thomas, 2006. "Currency Changeovers as Natural Experiments," Munich Dissertations in Economics 5839, University of Munich, Department of Economics.
- Brachinger, Hans Wolfgang, 2006. "Euro or "Teuro"?: The Euro-induced Perceived Inflation in Germany," DQE Working Papers 5, Department of Quantitative Economics, University of Freiburg/Fribourg Switzerland.
- Thomas A. Eife & Stephan Meier, 2007. "Costly Inflation Misperceptions," Working Papers 0455, University of Heidelberg, Department of Economics, revised Oct 2007.
- Bettina Isengard & Thorsten Schneider, 2006. "The euro and its perception in the German population," Discussion Papers 011, Europa-Universität Flensburg, International Institute of Management.
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Incroyables by Melissa May Spring 2009 Fashion Show
Melissa May, one of Denver's most talented local fashion designers, will be premiering her retro beach inspired Spring 2009 line tonight at 9 p.m. at the Colorado History Museum, 1300 Broadway.
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-- Aubrey Shoe
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Posted by David on Monday, January 23, 2012 at 11:40pm.
Use the Hf information to find delta H (DH) for the reaction .
DHrxn = (n*DHf products) - (n*DHf reactants). That is the number of joules (or kJ but keep it all straight) available from the reaction as written.
Now, how much heat do you need.
You need to melt the ice.
mass ice x heat fusion = ?
You need to raise T of H2O from zero C to 100 C.
mass ice melt (85g) x specific heat water x 100 = ?
The sum of those two = amount of heat needed.
g C4H10 needed = 116g x (kJ needed/kJ rxn)
Check my work. It's late here.
Okay, so I got:
DHrxn = 8(395.5)+10(-241.83)-[2(-127.7)+13(o)
=-5326.9 kJ
mass(moles) ice x heat fusion 4.718mol(85/18.016)*6.01KJ/mol? =28.355Kj
Then I have 4.718mol *75.291J/mol/oC x 100= 35522.2938J
so sum together= 28.355kJ + 35.522 =
then 2(58) x (63.877/-53269kJ))=0.1391g
I'm not sure if I did this right I may have went wrong in the first step, so if you could steer me in the right direction it would be appreciated,
I found one SMALL math error and one large math error.
You used DHfCO2 = -395.5 but your post (and my text) shows -393.5 but that makes only a small difference in the problem. . The larger error is the last step where you typed in 53269 and you omitted the decimal; it should be 5326.9(actually with the correction of the CO2 I have 5316.9 for this). That changes the answer by a factor of 10 so it is 1.39 g C4H10 needed.
How did you get g C4H10 needed??? I'm also working on this question
g C4H10 needed = 2(58) x (63.877/5316.9) = ?


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Ice Fishing in Alaska
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Ice Fishing in Alaska / Caitlind L. Alexander
Summary: A fun early reader story about how to go Ice Fishing in Alaska, and all of the things that can go wrong when you do.


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The goal of the Mayor's Healthy Hometown Movement (MHHM) is to create a culture of health and wellness in our hometown with a vision of becoming one of the healthiest cities in America.
Preventing disease and maintaining good health is easier when people and communities are surrounded by environments where the healthy choice is the easy choice.
Improving health is everybody's business so we work to convene, connect, and communicate through public-private partnerships that leverage resources to establish healthier places, programs and policies toward making Louisville one of the healthiest cities in the country.
The Mayor's Healthy Hometown Movement Leadership Team, modeled after the National Prevention Council, brings together key leaders throughout Metro Government who oversee organizations that impact residents' abilities to make healthy choices in their homes, child care facilities, educational facilities, workplaces and neighborhoods. This Mayoral initiative is designed to dramatically improve the health of Metro Louisville residents by using a health in all policies approach.This approach considers the health ramifications of all government policy, particularly in such areas as community design and land use planning, housing, transportation, education, and fiscal sectors. We want to put health at the heart of the public policy process and to further evidence-based policy making.
The Mayor's Healthy Hometown Movement (MHHM) Community Coalition is an umbrella partnership, dedicated to transforming community and public health across Louisville Metro. It embraces a prevention-driven health-in-all-policies perspective, applies a learning collaborative model, facilitates active community engagement, and prioritizes equity.
The Mayor's Healthy Hometown Community Coalition is made up of four committees that reflect the four current focus areas of our efforts:
Active Living Committee works to make active living a way of life that integrates opportunities for physical activity into daily routines. Promote active environments and transportation.
Chronic Disease Prevention Committee works to make preventing chronic disease a priority for all Louisville Metro residents, engaging all sectors – health and primary care, behavioral and public health, as well as the community.
Healthy Eating Committee works to make healthy eating of fresh fruit, vegetables and other foods the easy choice for residents of all ages and incomes, for every meal, every day.
Tobacco-Free Living Committee wants to make tobacco-free living the easy choice for all Louisville Metro residents, of all ages and incomes, regardless of space, place or setting.
Schools, work sites, faith organizations play an important role in the Mayor's Healthy Hometown Movement because they can have an impact across all four committee areas.
If you're interested in learning more contact us.
The Mayor's Healthy Hometown Movement is directed by Dr. Joan Schulte, director, Louisville Metro Public Health & Wellness, in cooperation with a leadership team of all Louisville Metro agency directors to inform the development of organization and legislative policies that impact health.


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Carlo Ancelotti saw Chelsea go five points clear at the top of the Barclays Premier League with a 1-0 win over Manchester United and then accused the visitors of trying to influence the referee.
Captain John Terry claimed the winning goal in the 76th minute, although the ball went in off Nicolas Anelka, as the Blues kept their 100% home record under Ancelotti.
In a stormy second half, Darren Fletcher waved an imaginary card at referee Martin Atkinson in an apparent attempt to get Chelsea defender Ricardo Carvalho dismissed for a tackle on Wayne Rooney.
Carvalho had already been booked by Atkinson but Fletcher's attempt fell on deaf ears.
It was just one of a number of confrontations between the referee and players from both sides in a tetchy affair which did little for the reputation of English football.
"The Manchester players protested a lot," said Ancelotti. "I don't know why. I don't like this. At the end of a very difficult match, all the players worked very hard - and sometimes it can happen."
Ferguson may now find himself in more trouble with the Football Association after criticising Atkinson's decision-making in the build-up to Terry's winner.
Ferguson, who branded Alan Wiley "unfit" last month, was adamant that Atkinson's judgement was the kind which lead managers and players to "lose faith in refereeing".
Atkinson awarded a free-kick for Fletcher's challenge on Ashley Cole, and Wes Brown appeared to be impeded as Frank Lampard's delivery was turned into the net by a combination of Terry and Anelka.
"Clearly, Darren Fletcher's won the ball - Ashley Cole's never touched and has jumped up in the air - and then (Didier) Drogba's pulled Brown to the ground for the goal," said Ferguson.
"The referee's position to make the decision was absolutely ridiculous - he can't see anything. He's got a Chelsea player (Joe Cole) standing right in front of him - and he doesn't even move.
"It was a bad decision, but there's nothing we can do about it. You lose faith in refereeing sometimes, that's the way the players are talking in there - it was a bad one.
"That goal should never have been allowed. We've dominated the game. We've had great chances to win the match, and that's our fault.
"We had great opportunities to get to the edge of the box and some really good chances in and around the box, but we should be finishing it off.
"We've only ourselves to blame in that respect. But you do need a break - and we never got the break we needed."
Ancelotti admitted Drogba might have been offside for Chelsea's winner but said: "It was very difficult for the linesman to see. There was a lot of concentration of players in the box.
"We are in a good position in the Premier League and in the Champions League. The players have done very well. We have to continue, because there will be other strong matches like that."
Ferguson, meanwhile, admitted the defeat - United's third on the road this season - was more significant than their recent 2-0 reverse at Liverpool.
"The fact is Chelsea go five points clear of us," he said.
"The defeat to Liverpool didn't affect our position in the league."
Chelsea captain Terry and team-mate Anelka were left arguing over who got the winning goal.
Terry said: "I got a touch on it but I think maybe Nico (Anelka) got the second touch - but I'm still claiming it.
"I was watching the stats before the game and I've never scored against them home and away. But Nico's been brilliant today, so he deserves it."
Anelka added: "I think I touched the ball, but maybe John will claim it. We played good football and we had some chances - but we stayed compact in defence."
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Functional Programming Languages and Computer Architecture
Volume 201 of the series Lecture Notes in Computer Science pp 113-128
How to replace failure by a list of successes a method for exception handling, backtracking, and pattern matching in lazy functional languages
- Philip WadlerAffiliated withProgramming Research Group, Oxford University
* Final gross prices may vary according to local VAT.Get Access
Should special features for exception handling, backtracking, or pattern matching be included in a programming language? This paper presents a method whereby some programs that use these features can be re-written in a functional language with lazy evaluation, without the use of any special features. This method may be of use for practicing functional programmers; in addition, it provides further evidence of the power of lazy evaluation. The method itself is straightforward: each term that may raise an exception or backtrack is replaced by a term that returns a list of values. In the special case of pattern matching without backtracking, the method can be applied even if lazy evaluation is not present. The method should be suitable for applications such as theorem proving using tacticals, as in ML/LCF.
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- Title
- How to replace failure by a list of successes a method for exception handling, backtracking, and pattern matching in lazy functional languages
- Book Title
- Functional Programming Languages and Computer Architecture
- Book Subtitle
- Nancy, France, September 16–19, 1985
- Pages
- pp 113-128
- Copyright
- 1985
- 10.1007/3-540-15975-4_33
- Print ISBN
- 978-3-540-15975-9
- Online ISBN
- 978-3-540-39677-2
- Series Title
- Lecture Notes in Computer Science
- Series Volume
- 201
- Series ISSN
- 0302-9743
- Publisher
- Springer Berlin Heidelberg
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- Springer-Verlag
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- Philip Wadler (1)
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- 1. Programming Research Group, Oxford University, 11 Keble Road, OX1 3QD, Oxford
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Wego.com.sg recently found 12 hotels in Fort Mill, United States. Find a range of accommodation in Fort Mill at great prices. Book luxury Fort Mill hotels or find last minute accommodation. Save more on cheap hotels in Fort Mill with affordable room rates.
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The group's share price has soared recently, rising from 550p in April to 847.5p, up 1p yesterday, as the group posted a 20 per cent rise in half-year profits to June at pounds 25m, beating expectations. The market was also cheered by news of Cobham's strong order book and a string of niche buys.
The year ahead for Cobham looks pretty solid. Its FR Aviation arm, which sells aircraft components, is currently refurbishing 21 Nimrod planes and looks set for more orders from the Ministry of Defence.
Demand is growing for its traditional flight refuelling services, including more business with the Singapore Air Force, and Chelton, which supplies radio antennae, looks set to benefit from the recent acquisition spree. Even problem child Westwind should have a good year, with a variety of innovations like low-cost scanners in the pipeline.
Cobham plans to splash some cash in the months to come. The group is budgeting for pounds 15m-pounds 20m of capital expenditure in the second half, most of which is earmarked for infrastructure improvements. Neither is the company ruling out further acquisitions. Gearing is expected to jump from 6.6 per cent to 40-5 per cent.
The real problem with Cobham is not its growth prospects or even its increased gearing level. The company is simply over-rated. Forecasts put it on a prospective p/e of more than 22, too high for a business predicted to grow profits by 19 per cent this year. Now may be the time for shareholders to sell out.
- More about:
- Electronics
- Engineering
- Mergers And Acquisitions
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"I don't care if I have a whole division full of lesbians, if they can do the job. Look, we kicked out a bunch of gay men who were linguists, Arabic specialists. What kind of stupidity is that?"
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"To be poor in a rich country is difficult, but it's nice to know that there are millions like me who are willing to make it happen for them."
"Introductions are tricky in a lesbian relationship. It's a word game. To my friends she's my lover, to strangers and family members in denial she's my roommate, to Jehovah's Witnesses at the door she's my lesbian sex slave, and to my mother she's Jewish and that's all that matters."
"Women who love women are Lesbians. Men, because they can only think of women in sexual terms, define Lesbian as sex between women."
"Every gay and lesbian person who has been lucky enough to survive the turmoil of growing up is a survivor. Survivors always have an obligation to those who will face the same challenges."


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Campaigners call on UK government to stop exporting arms to Egypt
Campaigners call on UK government to stop exporting arms to Egypt
As three Al-Jazeera journalists have been sentenced to seven years in prison, Campaign Against Arms Trade (CAAT) has called for an immediate end to all arms sales to the Egyptian regime. This follows the recent mass trial that recommended the death penalty for 683 people – including Muslim Brotherhood leader Mohammed Badie.
In 2013 alone, the UK approved £51 million of arms licences to Egypt, including assault rifles, pistols and components for military vehicles and aircrafts. Since the Arab Spring the UK has approved over £70 million of military licences, which represents a ten-fold increase on the three years prior to it.
CAAT says the UK has continued to sell arms to Egypt following the military coup in late June 2013, only revoking a handful of arms licences in July after the military massacred dozens at a sit-in. In October 2013, following a review, the UK government revoked seven further licences as they concluded that the weapons could be used for internal repression. At the same time the government lifted the temporary suspension on 24 licences and maintained it for another 16.
All exports of military equipment, whether or not they can directly be used in repression, send a message of UK support to the recipient regime, and undermine calls to respect human rights. The UK government should immediately revoke all extant export licences to Egypt and any the processing of applications in the pipeline, said CAAT
Andrew Smith, a spokesperson for Campaign Against Arms Trade, said: "The Arab Spring should have seen a re-evaluation of how the UK does business with Egypt, but instead it has been treated as a business opportunity.
"When the UK sells weapons to the Egyptian government it is not just giving them military support, it is also giving them political support and the UK's explicit endorsement. If the UK government is on the side of Egyptian people then it needs to recognise the unstable political situation and stop all arms sales immediately."
arms export licensing arms exports caat. campaign against arms trade egypt repression uk government
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Editor Profile
Anthony L. Komaroff, MD
Founding Editor
About the NEJM Journal Watch General Medicine Board
Dr. Komaroff is Professor of Medicine at Harvard Medical School. He served for 15 years as Director of the Division of General Medicine and Primary Care at Brigham and Women's Hospital; was the hospital's Vice President for Management Systems; was for 18 years the editor-in-chief of the Harvard Health Publications division of Harvard Medical School; and is the Founding Editor of NEJM Journal Watch General Medicine. He maintained a primary care medical practice for 44 years. Dr. Komaroff has published more than 270 research articles and book chapters, and two books; has served on advisory committees for the Surgeon General, the Centers for Disease Control and Prevention, and the National Academy of Sciences; and has been elected to fellowship in the American College of Physicians and the American Association for the Advancement of Science.
Harvard Medical School: Harvard Health Publications; Harvard Health Letter; Ask Doctor K
Summaries by Anthony Komaroff
- February 21, 2017
A Step Forward in the Quest for a "Liquid Biopsy"
- Anthony L. Komaroff, MD
A new technique allows detection of extremely small numbers of circulating cancer cells.
- January 24, 2017
Huge Study Links a Specific Gene to Appetite for Alcohol
- Anthony L. Komaroff, MD
A neuroendocrine loop might be responsible for drinking behavior.
- January 3, 2017
DNA Vaccine Against Zika Virus Yields Promising Results in Primates
- Anthony L. Komaroff, MD
A single dose provided protection in rhesus macaques.
- January 3, 2017
Is Social Network Activity Associated with Lower Mortality?
- Anthony L. Komaroff, MD
Facebook users with more friends and more requests to connect lived longer.
- October 20, 2016
Does Political Party Affiliation Affect a Doctor's Advice to Patients?
- Anthony L. Komaroff, MD
Depending on a patient's health issue, the answer might be yes or no.
- October 18, 2016
Biological Measures of Human Aging Gain Credibility
- Anthony L. Komaroff, MD
Telomere length and DNA methylation can be used to predict lifespan.


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Our long-term goal is to develop therapeutic strategies that improve the survival of patients with disseminated melanoma by potentiating new and existing targeted therapies. Despite the impressive responses achieved in BRAF mutant melanoma patients treated with BRAF inhibitors, resistance inevitably occurs. A number of potential resistance mechanisms have been described, the majority of which bypass mutant BRAF through the reactivation of MAPK and PISK/AKT signaling. Although current clinical strategies are focused upon the use of BRAF inhibitors in conjunction with MEK or PISK inhibitors, the development of multiple, subtle signaling alterations at many nodes within the melanoma signaling network is likely to result in eventual resistance even to these combinations. Conceptually, we believe that the adaptive signals that mediate resistance in the majority of cases are both "tumor-intrinsic", resulting from the rewiring of the melanoma signal transduction network, as well as "host-derived", mediated by altered growth factor secretion and extracellular matrix from stromal fibroblasts. Our working hypothesis is that long-term abrogation of resistance will only be achieved if BF^F can be targeted in addition to multiple receptor tyrosine kinase (RTKs) and cell/matrix adhesion signals. Our preliminary studies suggest that most if not all of the signaling proteins implicated thus far in the escape from BRAF inhibitor therapy are clients of heat shock protein (HSP)-90, and we showed that inhibition of HSP90 was effective at preventing and overcoming resistance both in vitro and in vivo. In this proposal, we will use innovative phosphoproteomic- and chemical proteomic-based systems biology approaches to define the HSP "clientome" that drives intrinsic and acquired resistance of melanomas to MAPK pathway inhibition (BRAF, MEK and BRAF+MEK). We will further investigate the role of fibroblast-derived signals in remodeling the HSP-clientome of melanoma cells and will determine how this allows the tumor to escape MAPK inhibitor-mediated apoptosis. Pre- and post-treatment biopsies from melanoma patients receiving a BRAF and HSP90 inhibitor combination (vemurafenib+XL888) will be analyzed to look for patterns of HSP client protein degradation associated with long-term therapeutic response. Together, these studies are expected to give a systems level view of how melanoma cells resist MAPK pathway inhibition and will provide new paradigms to overcome drug resistance in melanoma.
Although small molecule inhibitors of BRAF and MEK and the BRAF+MEK inhibitor combination are showing great promise as novel melanoma therapies, their effectiveness is severely limited by both acquired and intrinsic drug resistance. The aim of the proposal is to use phospho-proteomics, chemical proteomics and network modeling to identify the key mechanisms of therapeutic escape and to perform preclinical experiments and to analyze specimens from an ongoing phase I clinical trial to determine whether inhibition of HSP90 abrogates the onset of BRAF inhibitor resistance.
|Rebecca, Vito W; Wood, Elizabeth; Fedorenko, Inna V et al. (2014) Evaluating melanoma drug response and therapeutic escape with quantitative proteomics. Mol Cell Proteomics 13:1844-54
|Kim, Sungjune; Ramakrishnan, Rupal; Lavilla-Alonso, Sergio et al. (2014) Radiation-induced autophagy potentiates immunotherapy of cancer via up-regulation of mannose 6-phosphate receptor on tumor cells in mice. Cancer Immunol Immunother 63:1009-21
|Smyth, Tomoko; Paraiso, Kim H T; Hearn, Keisha et al. (2014) Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma models. Mol Cancer Ther 13:2793-804
|Haarberg, H Eirik; Smalley, Keiran S M (2014) Resistance to Raf inhibition in cancer. Drug Discov Today Technol 11:27-32
|Rebecca, Vito W; Smalley, Keiran S M (2014) Change or die: targeting adaptive signaling to kinase inhibition in cancer cells. Biochem Pharmacol 91:417-25
|Johnson, Douglas B; Smalley, Keiran S M; Sosman, Jeffrey A (2014) Molecular pathways: targeting NRAS in melanoma and acute myelogenous leukemia. Clin Cancer Res 20:4186-92
|Rebecca, Vito W; Alicea, Gretchen M; Paraiso, Kim H T et al. (2014) Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma. Pigment Cell Melanoma Res 27:1154-8
|Cheng, Fengdong; Lienlaf, Maritza; Perez-Villarroel, Patricio et al. (2014) Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Mol Immunol 60:44-53
|Rebecca, Vito W; Massaro, Renato R; Fedorenko, Inna V et al. (2014) Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma. Pigment Cell Melanoma Res 27:465-78
|Fedorenko, Inna V; Fang, Bin; Koomen, John M et al. (2014) Amuvatinib has cytotoxic effects against NRAS-mutant melanoma but not BRAF-mutant melanoma. Melanoma Res 24:448-53


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What do u guys think of this he and the taxi driver had a massive argument over something and he pulled his gun fired one shot...would like to see the comments... Source: https://www.facebook.com/video.php?v=586868718080083&set=o.127739389330&typ e=2&theater I do not claim any ownership over this video.
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http://www.vladtv.com - A cab driver from Las Vegas survived a shooting during an ambush last week. According to the Las Vegas Review Journal, the shooting took place in the early hours of Feb. 11. The 62-year-old, who hasn't been named for safety reasons, responded to a call in the area for a taxi. The cabbie pulled into a neighborhood on Copper Stone Court where he was greeted by the suspects. After informing him that their "uncle" called the cab, they offered him water, which the cab driver declined. A few moments later, shots rang out and the cab driver was struck twice. Luckily, the cabbie was able to find EMT workers at a local truck stop area six minutes away. The paramedics told reporters if they didn't encounter the cabbie when they did, he could have lost his life. The cab driver was shot in the back and the other bullet ripped through his stomach. He is expected to make a full recovery. He is also in good spirits about the shooting, since the video will be used to train other cabbies how to survive dangerous encounters from potential customers.
Fatal Shooting Full Video
Davenport Iowa cop shoots and kills a man. The officer had stopped the man as suspect in an assault a few minutes beforehand. The man would not heed the officers request to get on his knees, and the officer used his tazer on the man but one prong didnt stick so the tazer didnt work. The man then attacked the officer, slamming his head into the concrete, biting the officers eye brow off, and severly beating him. The officer shot and kill the man. I believe the officer had every right to defend himself as he felt his life was in danger. Although some idiots here think he used too much force. Anyhow here is the whole video. To read part of the story go here http://www.qctimes.com/news/local/article_82a1f54e-82a3-11de-9019-001cc4c03 286.html and after reading the story click on the Images tab to see the photos of what the man did to the officer.


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The #MightyMacWalk16 condensed to about two minutes.View this complete post...
Posts Tagged 'MI'
Labor Day 2016: Walking the Mackinac BridgeMonday, September 12th, 2016
Michigan's Water Infrastructure Investment NeedsFriday, June 3rd, 2016
Currently, about 75 percent of Michigan residents get their drinking water from 1,390 community water systems, and approximately 70 percent are served by 1,080 wastewater treatment systems (MDEQ 10/31/15). Most of these systems were built between 50 and 100 years ago, while some in the state's oldest cities date back to the 1800s. Many of these systems are fast approaching, or have already exceeded, their expected lifespan. Communities throughout Michigan, therefore, face the challenge of maintaining and updating old infrastructure that was designed and built to meet former, less strict requirements, but now must meet emerging, more stringent state and federal drinking water, wastewater, and stormwater standards.
Saginaw County, MI: M-13's New Bridge Beam (Timelapse)Tuesday, May 31st, 2016
During the week of May 9, 2016, the Michigan Department of Transportation set bridge beams for the M-13 bridge over the Flint River in Saginaw County.View this complete post...
Why Is America's Water Infrastructure Failing?Wednesday, May 25th, 2016
Lead contamination in the drinking water of a Michigan city helped expose serious problems with America's water infrastructure. So how bad is the country's water crisis?View this complete post...
Outstanding Engineering: Michigan's "96fix" Highway RehabilitationMonday, April 11th, 2016
96fix was the largest single-season construction project in state history. Reconstruction of the seven-mile stretch of the 40-year-old freeway included the rehabilitation of 37 bridges, installation of LED lighting and storm sewers, and safety improvements. The $153 million project was completed early and under budget, and brought I-96 in line with current standards. Innovative technologies included visual modeling to gain public support for closing the freeway during construction and 3-D design model for fine-tuning paving work. The process saved taxpayer dollars, cut freeway closure time, and improved pavement quality and safety.View this complete post...
Corporate Demand for Renewable Energy in MichiganMonday, February 8th, 2016
Leading corporations nationwide have demonstrated their desire to purchase renewable energy. As of 2014, 43% of Fortune 500 companies and 60% of Fortune 100 companies have set climate and/or clean energy targets,1 and as of December 2015, 49 major corporations, representing a market cap of $15 trillion, have signed on to the Corporate Renewable Energy Buyers' Principles (see appendix).
Michigan DOT: 2015 Year End Wrap-UpWednesday, January 13th, 2016
State and community leaders talk about the success of several MDOT projects in 2015.View this complete post...
Michigan DOT: M-100 Bridge Slide Time LapseWednesday, November 25th, 2015
In the early morning hours of Saturday, Nov. 14, MDOT performed a bridge slide on the new M-100 bridge over the Canadian National (CN) Railroad in Potterville. A bridge slide is an innovative construction project that allows traffic to be maintained throughout the project. The new bridge is built alongside the old one, and once complete, the old bridge is demolished and the new bridge is slid over in its place.View this complete post...
Beyond Repair? America's Infrastructure Crisis Is LocalFriday, October 30th, 2015
While states own a large portion of highly traveled roads, such as interstate highways, local governments are responsible for the majority of roadway mileage. Counties and municipalities, including minor civil divisions such as townships, are responsible for 3.1 million miles of roads and streets. Only 430,000 miles (14 percent) of these are part of the federal aid system. The remaining 2.7 million (86 percent) are nonfederal aid. By contrast, 72 percent of the 780,000 miles of state-owned roads are in the federal aid system (Figure 1).
Detroit, MI: Green Infrastructure Pilot ProjectWednesday, September 23rd, 2015
University of Michigan landscape architect Joan Nassauer, a professor in the School of Natural Resources and Environment, leads a pilot project to design and build new forms of green infrastructure on vacant properties in Detroit's far-west-side Cody Rouge neighborhood. Four "bioretention gardens" that capture and hold stormwater are under construction now on sites where abandoned homes were razed.View this complete post...
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