text:
The pile continues to grow which means I have an excuse to have a continuing sound-track to anything I do in the flat and out. There is quite a bit of diversity in this lot from the laid-back acoustic groove of Shaw-Blades to the balls out old-school thrash of Toxik.
Halford: Metal God Essentials Volume 1
Now that Rob is back in Judas Priest, working on an album based on the life of Nostradamus, it is probably a good time to remind people of his solo career between stints in JP. All but the most ardent of Halford fans would admit that Rob's solo career has been patchy at best, especially his "cousin it" industrial bollocks with Two. Some say his band, merely called Halford, produced some of his best solo tracks. The opener "Resurrection" and the rather Maidenesque "Made in Hell" quite amply demonstrate this. The latter has some amusing lyrics that are typical of his double-entendre songwriting style.
The 15 tracks on this CD are a good reminder of the talent that is Halford when he is firing on all cylinders. If you are a fan of Judas Priest and resisted getting the Halford stuff out of loyalty, then this iTunes based (or via Halford Music) set might be a good idea. I thoroughly enjoyed this.
Leaves Eyes: Vinland Saga
Yes, I know I am a bit behind the times reviewing this set. But, at least, I have the pleasure of the enhanced version with its bonus track "Amelie" (new version) and "Heal" plus a video (Viking Wuthering Heights) for the cracking track "Elergy", an interview, and a making of clip. The Viking theme and Mrs Krull's lovely ethereal voice make for quite a pleasant heavy ride. They are set to have a new album out soon, one has to wonder how they are going to top this rather impressive CD. This is the sensitive, but not too much, side of the whole Viking metal genre. I found it the perfect accompaniment for reading Beowulf which I reviewed last week.
Sirenia: Nine Destinies and a Downfall
No, not the sequel to Four Weddings and a Funeral, but the new album from Sirenia a bloody impressive nine song collection of goth rock that sounds to me like Evanescence done properly with someone who can really sing. The only fault I have with this CD is that "the bonus" with the special edition is a bleeding poster, the radio edit of the track "My Mind's Eye," and video for said song.
The singer of this band works well with the name of the band with her clear siren vocal qualities. This is a bit lighter than say Leaves Eyes or Tristania but it certainly has enough of an edge to make it of interest to goths and metallers. Well worth seeking out.
Shaw/Blades: Influence
Now I loath cover albums, finding them to be a lazy way to milk the fans for a few more bob. If I wanted to hear the songs, I would find the originals and listen to them. It's a rather sad trend in some older bands.
Of course, when Tommy Shaw and Jack Blades do it, they make an effort to make things special. This is a jolly good album from two extremely talented people but it still leaves me wishing they would release another set of original stuff. That said, they do a great version of "Your Move" by Yes, not an obvious choice for a cover and approved by Jon Anderson himself.
Putting two Paul Simon compositions on here seemed a bit much, it has to be said, but their cover of "California Dreaming" is quite interesting. I think my preferred tracks on here are their covers of "Dance with Me" and "Dirty Work" but to be honest I see no point at all to this album. To me its one for completists only and I rather doubt I will ever listen to it again. If you like a cover album then this is probably one of the best you will ever hear.
Therion: Gothic Kabbalah
Just when you thought this lot couldn't get any more majestic, orchestral and operatic in their dark pomp, they pull something like this out of their hat. Not only is a themed album, hence the title, but it plays itself over two CDs. Now, the subject is deep, spiritual and dense but that does not mean Therion can not make the tunes as catchy as stink, almost sounding poppy at times. On "Son of the Slaves of Time" the male vocals sound always Joe Lynn Turner-esque while the female soprano vocals have a poppy sensibility that is almost Abba-esque. Then the next minute, as on "Adulruua Redibiba", they go all out prog-tastic ala Yes.
This band truly knows how to use all the voices we are born with plus the full compliment of symphonic and metal sounds. I could go on, but it seems pointless. This is one of the top metal albums ever made, an album that even puts Opeth's Ghost Reveries to shame. Not many bands could be called genius without a snicker, but Therion are truly geniuses of operatic metal. It does not get any better than this.
Toxik: World Circus and Think This
These two albums, part of the Roadrunner re-issue series, are very much a tale of two singers. Toxik played progressive/almost jazzy thrash, which you could argue was rather ahead of its time. The only trouble with World Circus is their dire singer at the time, who has ironically rejoined. His screech overshadowed the quality of some of the track therein. Included are several bonus tracks.
What might be of interest, is the rather good follow-up. With a new singer Charles Sabin, who shares a vocal style with Steve Rothery of Marillion, there is less distraction from the cleverness of the band. Tracks like "War NJN 8/In God" clearly show the skill of the band. As with the former there are a couple of live bonus track. This CD stands the test of time far better and it's clear to show its influence on modern technical metal.
Well, that is your copious lot for this week. While I dive back into the pile next to me please be safe, rocking, and catch live gigs if you can.Powered by Sidelines


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subset: commoncrawl


text:
Over at The Scriptorium we're as shocked and horrified as everyone else by the magnitude of the disaster in New Orleans and Mississippi and we want to do what we can to help. Since we make fonts, we're going to put those fonts to work for disaster relief and offer a little incentive bonus for supporting the Red Cross.
We have several fonts which are associated in one way or another with the city of New Orleans. Each day during the next week we're going to take all proceeds from the sales of one of those fonts and donate it to the Red Cross disaster relief fund. We'll change fonts every couple of days so you can donate more than once and get more than one cool font for your efforts. At the end of the period we'll total up the donations and pointlessly declare one of the fonts the winner – but hopefully everyone wins with this plan, since the Red Cross gets money and font fans get fonts while helping out the victims of Hurricane Katrina.
The first font we're featuring is Ironworks, which has the look of letters made from wrought iron fence in the style for which New Orleans' Garden District is famous. This is also a new, slightly improved version of the font, featuring some special characters which can be put together to make a decorative wrought iron fence border. In addition to the New Orleans connection, Ironworks is naturally great for Halloween, which is coming up frighteningly soon.
To order Ironworks for MacOS or Windows just go to our Main Page and follow the link from ther eto order. You can stop back by in a few days to see the next font and get an update on how the fundraising is going. Orders are secure and we take all major credit cards and PayPal.
You can also make donations direct to the Red Cross Disaster Relief Fund through a link here at Blogcritics, and you can also donate by calling 1-800-HELP-NOW.


text:
in - of that fibers departs under. nerves. reach called that receptors or the receptors.
Description: product form, composition
priligy pills film-coated, round, biconvex, with extruded says "30" or "60" inside a triangle on one side; the cross-section of the Tablet core white, or almost white.
table 1:
-dapoxetine (in the form of hydrochloride) 30 mg or 60 mg
Excipients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate.
Composition of membrane shell: lactose monohydrate, hypromellose, titanium dioxide (E171), triacetin, stain iron oxide black (Đ172), iron oxide yellow (Đ172).
Pharmacological group: medication for the treatment of premature ejaculation.
Farmdejstvie: Dapoxetine is a unique, short-acting, selective serotonin reuptake inhibitor (SSRI). Clinically proven, that the drug is effective in the treatment of premature ejaculation in males aged 18 years and older. Approximately 27-34% of men of all ages suffer from premature ejaculation, reception Dapoksetina prolongs the duration of sexual intercourse in 3-4 times.
SSRIs block the receptors in the brain, absorbing serotonin acting selectively and delaying ejaculation. Unlike other drugs sparingly and selectively delaying ejaculation. Unlike other drugs sparingly and selectively delaying ejaculation. Unlike other medications selective
Indications:-for the treatment of premature ejaculation in men aged 18 to 64 years.
Category actions on the fetus: the drug priligy is not intended for use in women.
is priligy available in united states
Based on the limited amount of data from clinical trials, there is no reason to assume that dapoksetina man can affect pregnancy partner. Well-controlled studies of application of dapoksetina in pregnant women has been carried out.
It is unknown whether dapoxetine and its metabolites in breast milk.
Contraindications: hypersensitivity to dapoksetina gidrohloridu or any auxiliary component of the drug. expressed by heart disease (e.g., congestive heart failure II-IV class NYHA, heart disorders conductivity (AV-blokada 2-3 degree or SSSU) in the absence of Permanent pacemaker expressed CHD or defeat pump apparatus); the simultaneous admission of MAO inhibitors and reception within 14 days after the termination of their use. Similarly, MAO inhibitors should not be taken during 7 days after discontinuation of the drug priligy;
-simultaneous tioridazina and within 14 days after the termination of its use. Similarly, thioridazine should not be taken within 7 days after discontinuation of the drug priligy;
-simultaneous reception of serotonin reuptake inhibitors (selective serotonin reuptake inhibitors-SSRI), inhibitors of reverse takeover serotonin and norarenalina and tricyclic antidepressants) and other drugs with serotonergic activity (e.g., L-tryptophan, triptans, tramadol, linezolid, lithium, preparations of St. John's wort (Hypericum wort) and within 14 days after you stop taking these drugs. Similarly, these drugs should not be taken within 7 days after discontinuation of the drug priligy;
-simultaneous reception with active CYP3A4 inhibitors, such as ketoconazole, ritonavir, itrakonazolom, sakvinavirom, telitromicinom, nefazodonom, nelfinavirom, atazanavir, etc.;
moderate and severe violations of the liver;
-serious violations of the kidneys;
children and adolescents under the age of 18 years;
is lactose intolerance.
premature ejaculation drug priligy
If there is a history of the established or suspected orthostatic hypotension, as well as having a history of mania/hypomania or bipolar disorder treatment should be avoided.
With caution:
-weak or moderately expressed violations kidney function;
-simultaneous application with powerful inhibitors izofermenta CYP3A4 inhibitors and moderate CYP2D6 in patients with low activity genotipiceski izofermenta CYP2D6 and patients with high activity izofermenta CYP2D6 (in combination with moderate inhibitors izofermenta CYP3A4);
-the simultaneous use of drugs that affect platelet aggregation, and with an anticoagulant because of the risk of bleeding.
Dosage: for oral use. The tablet should be swallowed whole, with at least one full glass of water. Product priligy can be taken regardless of the meal.
Adult males from 18 to 64 years old:
The recommended initial dose for all males is 30 mg; This dose taken for 1-3 hours before sexual intercourse. Insufficient effect and good endurance dose 30 mg can be increased to 60 mg.
priligy und cialis zusammen einnehmen
Description of individual side effects:
Fainting with loss of consciousness, with bradycardia or stopover site sinussovogo have been observed in patients with holterovskom and monitorirovanii have been reported in clinical studies. The data is regarded as an undesirable phenomena associated with the use of the drug. Most of the cases were observed during the first 3:00 after taking the drug, after taking the first dose or associated with medical procedures (collection of blood, body position changes, measurement of HELL). Prodromal?nye symptoms are often preceded by faint.
The incidence of syncope and prodromal?nyh symptoms depend on the dose that was demonstrated in patients receiving higher doses of the drug priligy.
Effects of withdrawal:
With the sudden cancellation of a long-used selective serotonin reuptake inhibitors for the treatment of chronic depessivnyh disorder observed the following symptoms: dysphoric State, irritability, psychomotor agitation, dizziness, sensory disorders (e.g. paresthesia), anxiety, confusion, headache, lethargy, emotional lability, insomnia, and hypomania. The results of the study showed a higher frequency of security of withdrawal symptoms as insomnia and dizziness of mild and moderate degree after the drug after 62 days of use.
Overdose: in clinical studies overdose not described.
Admission drug dose priligy to 240 mg (120 doses 2 mg at intervals of 3 h) did not cause unforeseen adverse events. Generally, SSRI overdose symptoms include serotoninergicakie reactions, including somnolence, gastrointestinal disorders (nausea, vomiting), tachycardia, tremor, agitation, and dizziness.
In overdose should, if necessary, carry out standard supportive care. Due to the significant drug binding to plasma proteins and the large volume of distribution of dapoksetina hydrochloride forced diuresis, dialysis, blood transfusions and gemoperfuzia are unlikely to be effective. Specific antidote unknown.
Interactions: do not take Dapoxetine from any of the following drugs:
Medications used to treat depression called "monoamine oxidase inhibitors" (MAOIs);
other drugs used to treat depression;
drugs used in the treatment of schizophrenia;
Lithium medications for treatment of bipolar disorder (Kerry Katona);
St. John's wort is a herbal medicine;
Tramadol is a powerful analgesic;
drugs used to treat migraines.
You should not take Dapoxetine from at the same time as any of the above drugs. In addition, you must stop the reception of these drugs for 14 days before you start taking Dapoksetina.
Within 7 days after reception of the Dapoksetina are not allowed to treat any of the following medicines:
some drugs used to treat fungal infections, including ketoconazole and itraconazole;
drugs used to treat HIV infection, including ritonavir, nelfinavir and atazanavir;
medications used to treat the infection, including telithromycin;
taking priligy and viagra together
Do not take Dapoxetine, if you are taking any of the drugs mentioned above. Be sure to consult your doctor if you should take other medicines along with taking the pill Dapoksetina.
Not recommended reception alcohol Dapoksetina, under the influence of alcohol may be amplified side effects that can lead to increased risk to your health.
You should also consult with your doctor before you take Dapoksetina if:
have you ever had any mental disorder;
side effects of priligy dapoxetine
you have blood clotting problems, kidney disease, epilepsy or dizziness, low blood pressure.
Before you start taking Dapoxetine need to check blood pressure, it should not be sliskomnizkim.
Special instructions: General:
The drug priligy is intended only for men with premature ejaculation. The safety of the drug in men without premature ejaculation is not installed, no ejaculation latency data.
The reception together with drugs:
Patients should be advised not to take the drug together with priligy drugs. Admission drug priligy drugs with serotonergic activity, such as ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid dietilamidom (LSD) can lead to potentially serious reactions, including, but not limited to, fibrillation, hyperthermia and serotoninergic syndrome. The admission of the drug priligy in conjunction with sedatives, such as opiates or benzodiazepines, may increase drowsiness and dizziness.


text:
Astron. Astrophys. Suppl. Ser. 133, 271-284
The beam pattern of the IRAM 30-m telescope
(a reflector with several surface error distributions)
A. Greve1 - C. Kramer2,3 - W. Wild2
Send offprint request: A. Greve
1 - IRAM, 300 rue de la Piscine, Domaine Universitaire, F-38406 St. Martin d`Hères, France
2 - IRAM, Nucleo Central, Avda. Divina Pastora 7, E-18012 Granada, Spain
3 - I. Physikalisches Institut, Universität zu Köln, Zülpicher Straße 77, D-50937 Köln, Germany
Received July 28, 1997; accepted June 11, 1998
Total power scans across the Moon around New Moon (mostly day time) and Full Moon (night time) at 3.4 mm (88 GHz), 2.0 mm (150 GHz), 1.3 mm (230 GHz), and 0.86 mm (350 GHz) wavelength are used to derive the beam pattern of the IRAM 30-m telescope to a level of approximately -30 dB (0.1) and, dependent on wavelength, to a full width of 1000 - 1400''. From the reflector surface construction and application of the antenna tolerance theory we find that the measurable beam consists of the diffracted beam, two underlying error beams which can be explained from the panel dimensions, and a beam deformation mostly due to large-scale transient residual thermal deformations of the telescope structure. In view of the multiple beam structure of the 30-m telescope, and of other telescopes with a similar reflector construction of (mini-)panels and panel frames, we summarize the antenna tolerance theory for the influence of several independent surface/wavefront deformations. This theory makes use of different correlation lengths, which in essence determine the independent error distributions, and of the wavelength-scaling of the diffracted beam and of the error beams.
From the Moon scans we derive the parameters for calculation of the 30-m telescope beam in the wavelength range 3 mm to 0.8 mm as required for the reduction of astronomical observations, in particular of extended sources. The parameters of the beam are primarily for the time after July 1997 when the reflector was re-adjusted and improved to the illumination weighted surface precision of mm.
In the Appendix we explain the choice for this analysis of scans taken around New Moon and Full Moon.
Key words: telescopes


text:
Already down to 152 pounds on Mother's Day, Cris Cyborg's nutritionist allows her a cheat meal. read news >>
TURIN, Italy – Bellator held their first international event this past weekend when Bellator 152 took place at Pala Alpitour in Turin, Italy. Days later, they announced Bellator 158, which takes plac read news >>
TURIN, Italy – Anastasia Yankova remained perfect as a professional at Bellator 152, scoring a first-round armbar submission of Anjela Pink.Filed under: Bellator, Featured Videos, News, Videos read news >>
TURIN, Italy – Patricky Freire's pursuit of a Bellator title shot has been a years-long affair. After his win at Bellator 152, though, he said he's finally done enough.Filed under: Bellator, Featured read news >>
TURIN, Italy – Following an emotional Saturday win in the Bellator cage, Italian vet Alessio Sakara wants to take a turn in the company's sister promotion.Filed under: Bellator, Featured Videos, News read news >>
In Bellator MMA's first international event, Patricky "Pitbull" Freire easily outfought a passive Kevin Souza to earn a unanimous-decision victory in the featured fight in Torino, Italy, on Saturday read news >>
Bellator MMA staged their inaugural international event, Bellator 152: Pitbull vs. Souza, at Italy's Pala Alpitour this weekend. read news >>
TURIN, Italy – Bellator's debut event outside of North America was filled with exciting finishes. That didn't include the headliner, however.Filed under: Bellator, News read news >>
TURIN, Italy – Anjela Pink has never stepped into a cage as a professional MMA fighter. But when Bellator called and asked her to make that debut on a televised card in Italy, the flyweight had no he read news >>
A.J. McKee drives fast cars too fast, can disassemble and reassemble any gun put in front of him, and occasionally eats too much cinnamon.Filed under: Bellator, Featured Videos, News, Videos read news >>
The Bellator 152 weigh-ins are in the books, and the fighters on the main card are official and set for their nationally televised fights.Filed under: Bellator, Featured Videos, News, Videos read news >>
Bellator has put together a card heavy on finishers for its first trip to Europe. The 10 fighters competing at Bellator 152 have 109 fights between them, and only 28 of those fights have gone the dis read news >>
MMA veteran Alessio Sakara is looking to score a knockout over Brian Rogers in the Bellator 152 co-main event in Torino, Italy on Saturday. read news >>
TURIN, Italy – Bellator is in Italy this week for the promotion's first international event, and MMAjunkie was on scene as the card's featured competitors were brought face to face for the first time read news >>


text:
|Property type
|Minimum Stay
Capture the magnificent rural views from the large covered verandah, soak up the atmosphere from the outdoor courtyard, take a walk in the bush right next to the cabin, or just relax in the comfort and warmth of the rustic charm the cabin has to offer.
The local Morepork is your night watchman under the uninterrupted twinkling of the Milky Way galaxy.
You have no neighbours, no cell phone reception, no TV, just Tui, Fantails, the local bird life plus the odd sheep and cow to keep you company.
Fancy a round of clay target shooting or archery? The cabin is located at the back of Carodale Country Estate, a 40 acre farm with it's own private clay target shooting ground. You can treat yourself to a round of two of shooting and archery at the best clay target shooting facility in the region! You will have exclusive use of the range with your own personal instructor World Title Holder and New Zealand Champion or one of Carodale's highly skilled and friendly personal instructors. POA.
Enjoy a guided walk in the dark to Carodale's "Glow Worm Gully". POA.
Carodale Cabin's rustic charm is complimented with pot belly stove, solar power, gas fridge, gas hot water, x2 gas cook top elements and gas BBQ/oven. Yes, it's all environmentally friendly.
A perfect private rural retreat, yet so close to Auckland for those just wanting time out from every day life, a romantic hideaway, or artist's /Within 10 mins you could be soaking in Waiwera's hot pools, walking the beaches of the Hibiscus Coast or enjoying a drink at the Puhoi Pub.or country cafe's Within 30 mins you can experience the wild west coast and Gannet colony at Murawai, or the vineyards, shops, beaches and restaurants of the Matakana/Warkworth area.
writers haven. With cycling so popular in the area, this is an ideal base whilst exploring the local country side on your bike.
Wainui, Waiwera, Puhoi, Kaukapapa, Waitoki, Silverdale, all within 15 minutes drive or less.
Special conditions:
Prices quoted are for x2 people. Additional quests $30 per person.
Carodale Country Estate is a working farm and Clay Target shooting range.
It is essential guest respect few simple rural etiquettes which will be explained on arrival.
Booking availability for short stay and overnight stays at Carodale Cabin are dependent on activities on the farm at the time.
Extras: Cleaning (included); Linen (Optional, NZ$25.00 per person);
Have a go Clay Target Shooting on our private shooting range, or guided walk to Glow Worm Gully!


text:
Taming Globalization
Frontiers of Governance
Edited by David Held Mathias Koenig-Archibugi
Format: Paperback
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Taming Globalization by David Held
Book DescriptionIn this volume some of the worlda s leading analysts of globalization discuss the economic, political and ethical implications of global economic integration. They assess the benefits and the costs of globalization and suggest strategies for reconciling it with the interests and aspirations of the people in all regions of the world. The contributors understand globalization not as a uniform process that should be praised or condemned in its entirety, but as a complex phenomenon that can and must be shaped and steered towards socially desirable goals. They reject the idea that the results of market processes are inexorable or invariably beneficial. On the contrary, they call for a robust global governance that is attentive to normative commitments -- the common good, social justice, and democratic accountability -- and does not reflect the overwhelming power of a handful of governments and corporate interests. Taming Globalization offers a fresh look at a much--debated topic, and sets out new ideas for curtailing and overcoming the negative aspects of global economic change. Contributors include Robert E. Goodin, David Held, Robert O. Keohane, John Gerard Ruggie, Joseph E. Stiglitz, and Robert Hunter Wade
Buy Taming Globalization book by David Held from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780745630779
(214mm x 159mm x 15mm)
Pages: 208
Imprint: Polity Press
Publisher: Polity Press
Publish Date: 12-May-2003
Country of Publication: United Kingdom
Other Editions...
Books By Author David Held
Global Political Theory, Paperback (August 2016)
Philosophers have never shied away from interrogating the nature of our obligations beyond borders.
Global Governance at Risk, Hardback (September 2013)
* A major new collection examining the economic and political challenges currently faced by multilateral and transnational governance institutions.
Climate Governance in the Developing World, Paperback (June 2013)
Since 2009, a diverse group of developing states that includes China, Brazil, Ethiopia and Costa Rica has been advancing unprecedented pledges to mitigate greenhouse gas emissions, offering new, unexpected signs of climate leadership.
Gridlock, Paperback (March 2012)» View all books by David Held
The issues that increasingly dominate the 21st century cannot be solved by any single country acting alone, no matter how powerful. To manage the global economy, prevent runaway environmental destruction, reign in nuclear proliferation, or confront other global challenges, we must cooperate.
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Author Biography - David Held
David Held is Graham Wallas Professor of Political Science at the London School of Economics and Political Science. Mathias Koenig--Archibugi is Research Fellow at the London School of Economics and Political Science.
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English Society, 1660-1832
Religion, Ideology and Politics During the Ancien Regime 2nd Revised edition
By (author) J. C. D. Clark
Format: Hardback
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English Society, 1660-1832 by J. C. D. Clark
Book DescriptionThis is a revised and extensively rewritten edition of a work first published in 1985 as English Society 1688-1832. That book arrived at the opening of a new phase in English historiography, which questioned much of the received picture of English society as secular, modernising, contractarian, and middle class; it began the recovery of the 'long eighteenth century', the period which saw a form of state defined by the close relationship of monarchy, aristocracy and church. In particular, it placed religion at the centre of social and intellectual life, and used ecclesiastical history to illuminate many historical themes more commonly examined in a secular framework. In its updated form, this book reinforces these theses with new evidence, which extends its arguments into fresh areas of enquiry.
Buy English Society, 1660-1832 book by J. C. D. Clark from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780521661805
(228mm x 152mm x 37mm)
Pages: 596
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 16-Mar-2000
Country of Publication: United Kingdom
Other Editions...
Books By Author J. C. D. Clark
Interpretation of Samuel Johnson, Hardback (June 2012)
A major academic controversy has raged in recent years over the analysis of the political and religious commitments of Samuel Johnson, the most commanding of the 'commanding heights' of eighteenth-century English letters. This book, one of a trilogy from Palgrave, brings that debate to a decisive conclusion, retrieving the 'historic Johnson.'
Politics of Samuel Johnson, Hardback (June 2012)
A major academic controversy has raged in recent years over the analysis of the political and religious commitments of Samuel Johnson, the most commanding of the 'commanding heights' of eighteenth-century English letters. This book, one of a trilogy from Palgrave, brings that debate to a decisive conclusion, retrieving the 'historic Johnson.'
Imperial Origins of the King's Church in Early America 1607-1783, Hardback (February 2004)
This volume provides a revisionist interpretation of the King's church as an instrument of imperial policy and an examination of the the civil and ecclesiastical agencies and leaders who implemented the policies for the development and supervision of the church in the American colonies.
Jacobite Movement in Scotland and in Exile, 1746-1759, Hardback (October 2003)» View all books by J. C. D. Clark
The principal conclusion of this book is that the Jacobite Movement persisted as a viable threat to the British state, and was perceived as such by its opponents to 1759.
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text:
Radiohead's Colin Greenwood in triathlon challenge
- 8 June 2014
- From the section Oxford
Radiohead star Colin Greenwood has conquered an Oxfordshire triathlon in support of a young girl with cancer.
The famous bassist joined hundreds of people at the Blenheim Palace Triathlon on Saturday after being inspired by nine-year-old Scarlett Clarkson, who is battling acute lymphoblastic leukaemia.
His team Scarlett's Dragons has raised more than £90,000 for Leukaemia & Lymphoma Research.
"If I could learn the front crawl I would definitely do it again," he said.
Greenwood added that the triathlon was "brilliant" and said: "Raising money for Scarlett's Dragons is the reason we are doing this and means everything."
Before the race, he said his band members had sent their best wishes.
The triathlon challenge was organised by Greenwood's neighbours, Scarlett's parents, Dan and Bryony, who put together a team of 22 men.
Mrs Clarkson said the team had been "fantastic" with their support.
Scarlett was diagnosed with acute lymphoblastic leukaemia, a cancer of the white blood cells, aged six.
Symptoms include pale skin, tiredness, breathlessness and unusual and frequent bleeding.
The triathlon is also taking place on Sunday.


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Maple Sweetened Indian Pudding
|4 Cup (64 tbs)
|Dark molasses
|2⁄3 Cup (10.67 tbs)
|Maple syrup
|1⁄2 Cup (8 tbs)
|Yellow corn meal
|2⁄3 Cup (10.67 tbs)
|1⁄3 Cup (5.33 tbs)
|1 Teaspoon
|Ground cinnamon
|3⁄4 Teaspoon
|Ground nutmeg
|3⁄4 Teaspoon
|4 Tablespoon, softened
Preheat oven to 225 degrees.
Combine 3 cups of the milk, the molasses, and syrup in the top half of a large double boiler and heat directly over medium-low heat to just below boiling; do not allow to boil.
Remove from heat, stir in corn meal, sugar, salt, cinnamon, and nutmeg and place over simmering water.
Stir in butter and cook, stirring, until thick.
Turn into a well-greased, 2-quart casserole.
Pour remaining cup of milk over pudding—do not stir—and bake in the center of the oven for 6 hours.
Serve warm with ice cream or whipped cream if desired.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 2734 Calories from Fat 739
% Daily Value*
Total Fat 84 g128.6%
Saturated Fat 49.3 g246.3%
Trans Fat 0 g
Cholesterol 219.4 mg73.1%
Sodium 2358.6 mg98.3%
Total Carbohydrates 465 g154.9%
Dietary Fiber 10.6 g42.2%
Sugars 322.7 g
Protein 39 g77.3%
Vitamin A 48.8% Vitamin C 0.43%
Calcium 232.3% Iron 160.4%
*Based on a 2000 Calorie diet


text:
Black Castro found another victim part2
Black Castro found another victim part3
My next victim
Lex Steele's Next Victim Ryan Conner
Found by mom having sexual intercourse
FakeAgentUK Conned by fake taxi fucked by fake agent
Beautiful flat-chested Korean Maya is glad to be her master's sexual victim
Giovanni Lovell claims his next victim once he's had his
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Real Estate in Indian Head Park, IL
Indian Head Park is located in Illinois. Indian Head Park, Illinois has a population of 3,807. Indian Head Park is less family-centric than the surrounding county with 27.69% of the households containing married families with children. The county average for households married with children is 32.09%.
The median household income in Indian Head Park, Illinois is $72,978. The median household income for the surrounding county is $54,648 compared to the national median of $53,046. The median age of people living in Indian Head Park is 53.3 years.
Indian Head Park Environment
The average high temperature in July is 85 degrees, with an average low temperature in January of 16.9 degrees. The average rainfall is approximately 38.5 inches per year, with 27.3 inches of snow per year.
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Research Topics
Genomes and Genes
Gene Symbol: SDHD
Description: succinate dehydrogenase complex, subunit D, integral membrane protein
Alias: CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS, succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, succinate-ubiquinone oxidoreductase cytochrome b small subunit, succinate-ubiquinone reductase membrane anchor subunit
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications250 found, 100 shown here
- SDHA is a tumor suppressor gene causing paragangliomaNelly Burnichon
Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service de Genetique, 20 40 rue Leblanc, F 75015 Paris, France
Hum Mol Genet 19:3011-20. 2010Mitochondrial succinate-coenzyme Q reductase (complex II) consists of four subunits, SDHA, SDHB, SDHC and SDHD. Heterozygous germline mutations in SDHB, SDHC, SDHD and SDHAF2 [encoding for succinate dehydrogenase (SDH) complex assembly ..
- Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paragangliomaHenri J L M Timmers
Reproductive Biology and Medicine Branch, National Institutes of Child Health and Human Development, Bethesda MD 20892 1109, USA
J Clin Oncol 25:2262-9. 2007..subunit B of the mitochondrial enzyme succinate dehydrogenase (SDHB) predispose to malignant paraganglioma (PGL). Timely and accurate localization of these aggressive tumors is critical for guiding optimal treatment...
- New advances in the genetics of pheochromocytoma and paraganglioma syndromesAnne Paule Gimenez-Roqueplo
Département de génétique, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, and Université de Paris, Faculte de Medecine, INSERM U772, College de France, France
Ann N Y Acad Sci 1073:112-21. 2006..of the SDH genes in 2000/2001 dramatically changed the genetics of pheochromocytoma (PHEO) and paraganglioma (PGL)...
- Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytomaJean Pierre Bayley
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
BMC Med Genet 7:1. 2006Germline mutations of the SDHD, SDHB and SDHC genes, encoding three of the four subunits of succinate dehydrogenase, are a major cause of hereditary paraganglioma and pheochromocytoma, and demonstrate that these genes are classic tumor ..
- Chromosome 11 monosomy in conjunction with a mutated SDHD initiation codon in nonfamilial paraganglioma casesKathrin Riemann
Institute of Pathology, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany
Cancer Genet Cytogenet 150:128-35. 2004..Mutations in a subunit of the mitochondrial enzyme II complex (succinate dehydrogenase [SDHD]) were shown to be responsible for the formation of paragangliomas...
- Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromesYing Ni
Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Hum Genet 83:261-8. 2008..One to five percent of SDHB/SDHD mutation carriers have renal cell or papillary thyroid carcinomas, which are also CS-related features...
- Germ-line mutations in nonsyndromic pheochromocytomaHartmut P H Neumann
Department of Nephrology and Hypertension, Albert Ludwigs University, Freiburg, Germany
N Engl J Med 346:1459-66. 2002..von Hippel-Lindau disease) now also encompasses the newly identified genes for succinate dehydrogenase subunit D (SDHD) and succinate dehydrogenase subunit B (SDHB), which predispose carriers to pheochromocytomas and glomus tumors...
- Molecular analysis of pheochromocytoma after maternal transmission of SDHD mutation elucidates mechanism of parent-of-origin effectPhey M Yeap
Department of Endocrinology, Western Infirmary, Glasgow G11 6NT, United Kingdom
J Clin Endocrinol Metab 96:E2009-13. 2011Pheochromocytoma/paraganglioma occurs almost exclusively after paternal transmission of succinate dehydrogenase D (SDHD) mutations...
- Genomic imprinting at a boundary element flanking the SDHD locusBora E Baysal
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
Hum Mol Genet 20:4452-61. 2011Germline mutations in SDHD, a mitochondrial complex II (succinate dehydrogenase) subunit gene at chromosome band 11q23, cause highly penetrant paraganglioma (PGL) tumors when transmitted through fathers...
- The endemic paraganglioma syndrome type 1: origin, spread, and clinical expressionFrancesca Schiavi
Department of Medicine, University of Padova, Familial Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology, Instituto di Ricovero e Cura a Carattere Scientifico, Via Gattamelata 64, 35128 Padova, Italy
J Clin Endocrinol Metab 97:E637-41. 2012Anecdotal evidence suggests a high incidence in Trentino, Italy, of head and neck paragangliomas (HNPGL), a rare autosomal dominant disease called paraganglioma type 1 syndrome and caused by germ-line mutations of the SDHD gene.
- Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutationsHartmut P H Neumann
Department of Nephrology and Hypertension, Albert Ludwigs University, Freiburg, Germany
JAMA 292:943-51. 2004Germline mutations of the genes encoding succinate dehydrogenase subunits B (SDHB) and D (SDHD) predispose to paraganglioma syndromes type 4 (PGL-4) and type 1 (PGL-1), respectively...
- Mutations in SDHD, a mitochondrial complex II gene, in hereditary paragangliomaB E Baysal
Department of Psychiatry, The University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
Science 287:848-51. 2000..Analysis of families carrying the PGL1 gene, described here, revealed germ line mutations in the SDHD gene on chromosome 11q23...
- Genetic testing in pheochromocytoma or functional paragangliomaLaurence Amar
Universite Paris Descartes, Faculte de Medecine, France
J Clin Oncol 23:8812-8. 2005To assess the yield and the clinical value of systematic screening of susceptibility genes for patients with pheochromocytoma (pheo) or functional paraganglioma (pgl).
- Genetics of pheochromocytoma and paraganglioma in Spanish patientsAlberto Cascon
Hereditary Endocrine Cancer Group, Institute de Salud Carlos III Center for Biomedical Research on Rare Diseases, Madrid, Spain
J Clin Endocrinol Metab 94:1701-5. 2009..In these cases, other clinical aspects like bilaterality, multiplicity, location of the tumors, or age at onset can help to recognize the underlying genes involved...
- Paraganglioma after maternal transmission of a succinate dehydrogenase gene mutationPascal Pigny
Laboratoire de Biochimie et Hormonologie, Centre de Biologie et Pathologie, Centre Hospitalier Regional and Universitaire, Lille Cedex, France
J Clin Endocrinol Metab 93:1609-15. 2008Inactivating mutations of SDHD, which is mapped to 11q23 and encodes the cybS subunit of succinate dehydrogenase, predispose to hereditary paraganglioma (PGL) and/or pheochromocytoma...
- Somatic loss of maternal chromosome 11 causes parent-of-origin-dependent inheritance in SDHD-linked paraganglioma and phaeochromocytoma familiesErik F Hensen
Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Centre, Albinusdreef 2, H4Q, 2333 ZA, Leiden, The Netherlands
Oncogene 23:4076-83. 2004Germline mutations in succinate dehydrogenase subunits B, C and D (SDHB, SDHC and SDHD), genes encoding subunits of mitochondrial complex II, cause hereditary paragangliomas and phaeochromocytomas...
- Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomasMassimo Mannelli
Department Clinical Pathophysiology, University of Florence, Viale Pieraccini 5, 50139 Florence, Italy
J Clin Endocrinol Metab 94:1541-7. 2009..The aim of the study was to define the frequency of hereditary forms and the genotype/phenotype correlations in a large cohort of Italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas...
- Fine mapping of a putatively imprinted gene for familial non-chromaffin paragangliomas to chromosome 11q13.1: evidence for genetic heterogeneityE C Mariman
Department of Human Genetics, University Hospital Nijmegen, The Netherlands
Hum Genet 95:56-62. 1995..65) with markers from the distal locus. These observations argue for the presence of two distinct imprinted genes for glomus tumors on 11q. A model for tumor initiation and progression is presented based on all available information...
- Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defectKristin Astrom
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Hum Genet 113:228-37. 2003..that often develop in the carotid body (CB) and is caused by mutations in the gene for succinate dehydrogenase D ( SDHD) of mitochondrial complex II...
- Germline succinate dehydrogenase subunit D mutation segregating with familial non-RET C cell hyperplasiaJorge Lima
Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200 465, Portugal
J Clin Endocrinol Metab 88:4932-7. 2003..We investigated the possible involvement of the SDHD gene, because somatic and germline mutations in this gene have been found in a variety of tumors of neural crest-..
- Succinate dehydrogenase D variants do not constitute a risk factor for developing C cell hyperplasia or sporadic medullary thyroid carcinomaAlberto Cascon
Hereditary Endocrine Cancer Group, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
J Clin Endocrinol Metab 90:2127-30. 2005..First, we studied SDHD in two families with hereditary non-RET CCH and found no alterations related to the inheritance of this disease...
- Denaturing high performance liquid chromatography detection of SDHB, SDHD, and VHL germline mutations in pheochromocytomaGoswin Y Meyer-Rochow
Kolling Institute of Medical Research, Royal North Shore Hospital and University of Sydney, Australia
J Surg Res 157:55-62. 2009..Type 1, and the pheochromocytoma/paraganglioma syndromes caused by mutations in the RET, VHL, NF1, SDHB, and SDHD genes, respectively...
- Genetic analyses of apparently sporadic pheochromocytomas: the Rotterdam experienceE Korpershoek
Department of Pathology, Josephine Nefkens Institute Room Be320a, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000DR Rotterdam, The Netherlands, and Department of Pathology, University Hospital Zurich, Switzerland
Ann N Y Acad Sci 1073:138-48. 2006..VHL gene), neurofibromatosis Type 1 (NF1 gene), or familial pheochromocytoma-paraganglioma (PCC-PGL) syndrome (SDHD/B and C genes)...
- Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD geneP E Taschner
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
Genes Chromosomes Cancer 31:274-81. 2001..Recently, we have identified the SDHD gene encoding subunit D of the mitochondrial respiratory chain complex II as one of the genes involved in ..
- No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinomaM Montani
Institute for Clinical Pathology, Department of Pathology, University Hospital Zurich, Switzerland
Endocr Relat Cancer 12:1011-6. 2005Germline mutations of the three succinate dehydrogenase subunits SDHB, SDHC and SDHD have recently been associated with familial pheochromocytoma and paraganglioma...
- Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomasJens Waldmann
Department of Surgery, University Hospital Giessen and Marburg, Baldingerstrasse, Marburg 35037, Germany
Endocrine 35:347-55. 2009The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively...
- Characterization of the human SDHD gene encoding the small subunit of cytochrome b (cybS) in mitochondrial succinate-ubiquinone oxidoreductaseH Hirawake
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
Biochim Biophys Acta 1412:295-300. 1999..Hirawake et al., Cytogenet. Cell Genet. 79 (1997) 132-138). In the present study, the human SDHD gene encoding cybS was cloned and characterized...
- The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiencyJean Pierre Bayley
Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, P, O, Box 9503, 2300 RA, Leiden, The Netherlands
BMC Med Genet 6:39. 2005The SDHA, SDHB, SDHC and SDHD genes encode the subunits of succinate dehydrogenase (succinate: ubiquinone oxidoreductase), a component of both the Krebs cycle and the mitochondrial respiratory chain...
- An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysisFrancien H van Nederveen
Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Lancet Oncol 10:764-71. 2009..This syndrome is caused by germline mutations in succinate dehydrogenase B (SDHB), C (SDHC), or D (SDHD) genes...
- Rare presentation of familial paraganglioma without evidence of mutation in the SDH, RET and VHL genes: towards further genetic heterogeneityAlexandre Persu
Cardiology Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
J Hypertens 27:76-82. 2009Mutations in genes encoding succinate dehydrogenase and its anchoring subunits (SDH genes) are at the origin of hereditary head and neck paraganglioma (PGL) and a subset of apparently sporadic pheochromocytoma.
- Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas suggest a common pathway to tumorigenesisErik F Hensen
Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, The Netherlands
BMC Med Genomics 2:25. 2009..mitochondrial succinate-dehydrogenase (SDH) complex are associated with hereditary paraganglioma: SDHB, SDHC and SDHD. Furthermore, a hereditary paraganglioma family has been identified with linkage to the PGL2 locus on 11q13...
- The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomasNelly Burnichon
Département de génétique, Hopital Europeen Georges Pompidou, 20 40 rue Leblanc, Paris, France
J Clin Endocrinol Metab 94:2817-27. 2009..Germline mutations in SDHx genes cause hereditary paraganglioma...
- L157X nonsense mutation of the succinate dehydrogenase subunit B gene in a Japanese patient with right paraaortic paragangliomaHaruhiro Sato
Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Endocrine 38:18-23. 2010..which encode two mitochondrial complex II subunits, are associated with the development of familial paraganglioma (PGL)...
- [Extra-adrenal pheochromocytoma associated to SDHD gene mutation]Nikolett Lendvai
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 150:645-9. 2009..represents in Hungary the first genetically confirmed case of hereditary paraganglioma/pheochromocytoma syndrome due to disease-causing mutation of the SDHD gene. Also, the authors review the progress of our knowledge about this syndrome.
- Resolution and reconstitution of succinate-ubiquinone reductase from Escherichia coliX Yang
Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma 74078, USA
J Biol Chem 272:9683-9. 1997..active, two-subunit succinate dehydrogenase and a two-subunit membrane anchoring protein fraction (the SdhC-SdhD fraction) by alkaline (pH 10...
- Expression of mRNAs for succinate dehydrogenase subunits and related genes in pheochromocytomaKazumasa Isobe
Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennnoudai, Tsukuba, Ibaraki 305 8575, Japan
Ann N Y Acad Sci 1073:253-62. 2006..In this study, we examined the level of expression of mRNAs encoding SDHB, SDHC, and SDHD in pheochromocytoma, pheochromocytoma subgroups, and normal adrenal gland, and compared the expression of these ..
- Two hydrophobic subunits are essential for the heme b ligation and functional assembly of complex II (succinate-ubiquinone oxidoreductase) from Escherichia coliK Nakamura
Department of Parasitology, University of Tokyo, Japan
J Biol Chem 271:521-7. 1996..Gene products of sdhC and sdhD are small hydrophobic subunits that anchor the hydrophilic catalytic subunits (flavoprotein and iron-sulfur protein)..
- Phase II study of high-dose [131I]metaiodobenzylguanidine therapy for patients with metastatic pheochromocytoma and paragangliomaSara Gonias
Department of Pediatrics, University of California, San Francisco, 350 Parnassus Ave, Suite 710, San Francisco, CA 94117, USA
J Clin Oncol 27:4162-8. 2009To evaluate the safety and efficacy of high-dose [(131)I]metaiodobenzylguanidine ([(131)I]MIBG) in the treatment of malignant pheochromocytoma (PHEO) and paraganglioma (PGL).
- The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patientsJean Pierre Bayley
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
BMC Med Genet 10:34. 2009Germline mutations of the tumor suppressor genes SDHB, SDHC and SDHD play a major role in hereditary paraganglioma and pheochromocytoma...
- The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme bQuang M Tran
Membrane Protein Research Group, Department of Biochemistry, University of Alberta, 473 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 281:32310-7. 2006..the [3Fe-4S] cluster of the SdhB subunit and the heme b(556) that is coordinated by His residues from the SdhC and SdhD subunits...
- Succinate dehydrogenase gene arrangement and expression in Anaplasma phagocytophilumRobert F Massung
Rickettsial Zoonoses Branch, CDC, Atlanta, GA 30333, USA
Gene 414:41-8. 2008..directly downstream of the Anaplasma phagocytophilum (strain MRK) 16S rRNA gene identified homologues of sdhC and sdhD; however, further sequencing by gene walking failed to identify additional sdh gene homologues...
- A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemiaBora E Baysal
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 2:e436. 2007..Germ line mutations in the SDHB, SDHC or SDHD genes cause hereditary paraganglioma (PGL) tumors which show constitutive activation of homeostatic mechanisms ..
- Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHABora E Baysal
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
BMC Biol 5:12. 2007..In contrast, heterozygous mutations in SDHB, SDHC, and SDHD, the other SDH subunit genes, cause hereditary paraganglioma (PGL) tumors, which show constitutive activation of ..
- Ubiquinone-binding site mutations in the Saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinateSamuel S W Szeto
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
J Biol Chem 282:27518-26. 2007..All of the mutants examined have reduced ubiquinone reductase activities. The SDH3 R47K, SDH4 D88E, and SDH4 D88N mutants are sensitive to hyperoxia and paraquat and have elevated rates of superoxide ..
- Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paragangliomaHenri J L M Timmers
Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 94:4757-67. 2009..MIBG), positron emission tomography (PET) agents are available for the localization of paraganglioma (PGL), including (18)F-3,4-dihydroxyphenylalanine (DOPA), (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG), and (18)F-..
- Pediatric paraganglioma: an early manifestation of an adult disease secondary to germline mutationsJaume Mora
Laboratori de biologia molecular dels tumors del desenvolupament i Oncologia Pediàtrica, Hospital Sant Joan de Deu de Barcelona, Spain
Pediatr Blood Cancer 47:785-9. 2006Paraganglioma (PGL) and phaeochromocytoma (PCC) are chemotherapy and radiation-resistant neuroendocrine tumors that arise from sympathetic tissue, and rarely occur in children...
- Proportion of heritable paraganglioma cases and associated clinical characteristicsC M Drovdlic
Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, PA, USA
Laryngoscope 111:1822-7. 2001To determine the heritable proportion of paraganglioma (PGL) and identify clinical features associated with heritable PGL.
- Isolation and characterization of the Saccharomyces cerevisiae SDH4 gene encoding a membrane anchor subunit of succinate dehydrogenaseB L Bullis
Department of Biochemistry, University of Alberta, Edmonton, Canada
J Biol Chem 269:6543-9. 1994..electrophoresis, determined the amino-terminal sequence of the Sdh4p subunit and used this information to clone the SDH4 gene...
- The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxiaJosé I Piruat
Laboratorio de Investigaciones Biomedicas, Edificio de Laboratorios, 2 planta, Hospital Universitario Virgen del Rocio, Avenida Manuel Siurot s n, E 41013 Seville, Spain
Mol Cell Biol 24:10933-40. 2004The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain...
- Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomasSimone Braun
Institute of Anthropology and Human Genetics, Division of Molecular Genetics, University of Tubingen, Germany
Anticancer Res 25:2809-14. 2005Paragangliomas are benign, slow-growing tumours of the head and neck region. The candidate gene for familial and some sporadic paragangliomas, SDHD (succinate dehydrogenase, subunit D), has been mapped to the PGL1 locus in 11q23.3.
- Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomasDiana E Benn
Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital, Syney, NSW, Australia
Oncogene 22:1358-64. 2003..In addition to mutations in RET and VHL in familial disease, germline mutations in SDHD and SDHB genes that encode subunits of mitochondrial complex II have also been associated with the development of ..
- The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiencyElisa Pedro-Segura
Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Avenida Doctor Moliner 50, E 46100, Burjassot, Valencia, Spain
J Biol Chem 283:28527-35. 2008..We demonstrate that the degradation of succinate dehydrogenase SDH4 mRNA, a known target of Cth2 on iron-deficient conditions, depends on Dhh1...
- Evolving concepts in the management of jugular paraganglioma: a comparison of radiotherapy and surgery in 88 casesPatrice Tran Ba Huy
Hopital Lariboisiere, Service ORL, Universite Paris 7, Paris, France
Skull Base 19:83-91. 2009Surgery for jugular paraganglioma (PGL) tumors often results in the acquisition of neurological deficits where none had been present previously. This has a significant impact on the quality of life...
- A current review of the etiology, diagnosis, and treatment of pediatric pheochromocytoma and paragangliomaS G Waguespack
Department of Endocrine Neoplasia and Hormonal Disorders, The Children s Cancer Hospital, University of Texas M D Anderson Cancer Center, PO Box 301402, Unit 1461, Houston, Texas 77230 1402, USA
J Clin Endocrinol Metab 95:2023-37. 2010Pheochromocytomas and paragangliomas (PHEO/PGL) are neuroendocrine tumors that arise from sympathetic and parasympathetic paraganglia...
- Familial nonsyndromic pheochromocytomaGiuseppe Opocher
Endocrinology Unit, Department of Medical and Surgical Sciences, University Hospital of Padova, Padova, Italy
Ann N Y Acad Sci 1073:149-55. 2006..familial pheochromocytoma has been largely elucidated and the role of germline mutation of the VHL, RET, SDHB, and SDHD genes has been established...
- Genomic imprinting and environment in hereditary paragangliomaBora E Baysal
Magee Women s Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 204 Craft Avenue, R332B, Pittsburgh, PA 15213, USA
Am J Med Genet C Semin Med Genet 129:85-90. 2004..PGL is caused by germ line heterozygous inactivating mutations in the SDHB (PGL4), SDHC (PGL3), or SDHD (PGL1) genes, which encode three of the four subunits of mitochondrial complex II (succinate dehydrogenase; SDH)...
- Mutation analysis of the SDHB and SDHD genes in pheochromocytomas and paragangliomas: identification of a novel nonsense mutation (Q168X) in the SDHB geneYohmi Oishi
Department of Health Sciences, Hokkaido University School of Medicine, Sapporo, Japan
Endocr J 57:745-50. 2010..VHL and NF-1, genes encoding succinate dehydrogenase complex subunit B (SDHB), subunit C (SDHC), and subunit D (SDHD) are recognized as susceptibility genes for PCC and PGL...
- Paraganglioma syndrome: SDHB, SDHC, and SDHD mutations in head and neck paragangliomasFrancesca Schiavi
Unità di Endocrinologia, Dipartimento Scienze Mediche e Chirurgiche, Universita di Padova, Italy
Ann N Y Acad Sci 1073:190-7. 2006..and pheochromocytoma, and is classified according to the three susceptibility genes involved, SDHB, SDHC, and SDHD. This study assessed the prevalence of germline mutations in SDHB, SDHC, and SDHD genes in a consecutive population ..
- Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromesAnthony J Gill
Department of Anatomical Pathology, Royal North Shore Hospital, Sydney 2065, Australia
Hum Pathol 41:805-14. 2010..RET, Von Hippel-Lindau (VHL), neurofibromatosis type I (NF1), and succinate dehydrogenase subunits (SDHB, SDHC, and SDHD) mutations...
- Childhood phaeochromocytoma and paraganglioma: 100% incidence of genetic mutations and 100% survivalPhilip J Hammond
Department of Paediatric Surgery, The Royal Hospital for Sick Children, Yorkhill, G3 8SJ Glasgow, United Kingdom
J Pediatr Surg 45:383-6. 2010..is to identify the incidence of genetic mutations and outcome of children presenting with phaeochromocytoma/paraganglioma (PGL) to a single paediatric surgical service to determine the need for genetic counselling in associated kindreds.
- Identification of a 4.9-kilo base-pair Alu-mediated founder SDHD deletion in two extended paraganglioma families from AustriaAndreas R Janecke
Division of Clinical Genetics, Innsbruck Medical University, Innsbruck, Austria
J Hum Genet 55:182-5. 2010..the development of highly vascularized paraganglionic tumors as a result of germline mutations in the SDHB, SDHC or SDHD subunit genes of succinate dehydrogenase (SDH; mitochondrial complex II), or in the Von Hippel-Lindau tumor-..
- Genetic mutation screening in an italian cohort of nonsyndromic pheochromocytoma/paraganglioma patientsM Castellano
Department of Internal Medicine, Laboratory of Molecular Medicine, University of Brescia, Italy
Ann N Y Acad Sci 1073:156-65. 2006..R230G in two patients, SDHB S8F, R46Q, R90Q, and VHL P81L in one subject each), and one with hnPGL carried the SDHD 348-351delGACT mutation...
- Clinical features of paraganglioma syndromesCarsten Christof Boedeker
Department of Otorhinolaryngology Head and Neck Surgery, University of Freiburg, Freiburg, Germany
Skull Base 19:17-25. 2009..PGLs 1-4) have been described: PGL 1 is associated with mutations of the succinate dehydrogenase (SDH) subunit D (SDHD) gene; PGL 3 is caused by SDHC gene mutations; PGL 4 is caused by SDHB gene mutations; the susceptibility gene for ..
- Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytomaJean Pierre Bayley
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
PLoS ONE 4:e7987. 2009..Mutations of SDHD, the first protein of intermediary metabolism shown to be involved in tumorigenesis, lead to the human tumors ..
- No evidence for involvement of SDHD in neuroblastoma pathogenesisKatleen De Preter
Center for Medical Genetics, Ghent University Hospital, K5, De Pintelaan 185, B 9000 Ghent, Belgium
BMC Cancer 4:55. 2004..The deleted region harbours the tumour suppressor gene SDHD that is frequently mutated in paraganglioma and pheochromocytoma, which are, like neuroblastoma, tumours ..
- SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytomaJean Pierre Bayley
Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
Lancet Oncol 11:366-72. 2010Paragangliomas and phaeochromocytomas are neuroendocrine tumours associated frequently with germline mutations of SDHD, SDHC, and SDHB...
- Malignant pheochromocytomas and paragangliomas: a phase II study of therapy with high-dose 131I-metaiodobenzylguanidine (131I-MIBG)Paul A Fitzgerald
Department of Medicine, UCSF Comprehensive Cancer Center, Box 1222, University of California, San Francisco, San Francisco, CA 94143 1222, USA
Ann N Y Acad Sci 1073:465-90. 2006Thirty patients with malignant pheochromocytoma (PHEO) or paraganglioma (PGL) were treated with high-dose 131I-MIBG. Patients were 11-62 (mean 39) years old: 19 patients males and 11 females...
- Paraganglioma, neuroblastoma, and a SDHB mutation: Resolution of a 30-year-old mysteryR Neil Schimke
Department of Medicine, Kansas University School of Medicine, Kansas City, Kansas 66160, USA
Am J Med Genet A 152:1531-5. 2010Familial paraganglioma/pheochromocytoma (PGL/PCC) is genetically heterogenous with mutations in three of the four subunits of the heterotetrameric mitochondrial complex II enzyme succinate dehydrogenase (SDH) being causally responsible ..
- Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeastElena Maklashina
Molecular Biology Division, VA Medical Center, Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
Biochim Biophys Acta 1797:747-54. 2010..The axial ligands for the low spin heme b in Escherichia coli complex II are SdhC His84 and SdhD His71. E...
- Fine analysis of the short arm of chromosome 1 in sporadic and familial pheochromocytomaG Opocher
Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
Clin Endocrinol (Oxf) 59:707-15. 2003..25% of apparently sporadic forms of pheochromocytoma are actually due to germline mutations of RET, VHL, SDHB or SDHD genes, the genetic bases of the tumourigenesis of this type of cancer are still incompletely understood...
- Retention of heme in axial ligand mutants of succinate-ubiquinone xxidoreductase (complex II) from Escherichia coliE Maklashina
Molecular Biology Division 151 S, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Biol Chem 276:18968-76. 2001..In the E. coli enzyme, heme b(556) is ligated between SdhC His(84) and SdhD His(71). Contrary to a previous report (Vibat, C. R. T., Cecchini, G., Nakamura, K., Kita, K., and Gennis, R. B...
- Fluorine-18 DOPA PET imaging of paraganglioma syndromeIngo Brink
Department of Radiology, Albert Ludwigs University, Freiburg, Germany
Clin Nucl Med 31:39-41. 2006..The patient carries a mutation of the gene Succinate dehydrogenasis subunits D (SDHD) and is thus classified with the paraganglioma syndrome type 1.
- In vitro anti-influenza virus activities of sulfated polysaccharide fractions from Gracilaria lemaneiformisMei Zhen Chen
Department of Biology of Shantou University, Shantou, 515063, China
Virol Sin 25:341-51. 2010..Cytotoxicities and antiviral activities of Gracilaria lemaneiformis polysaccharides (PGL), Gracilaria lemaneiformis polysaccharide fraction-1 (GL-1), Gracilaria lemaneiformis polysaccharide fraction-2 (GL-..
- Enhanced gene expression in epithelial cells transfected with amino acid-substituted gemini nanoparticlesPeng Yang
Department of Chemistry, University of Saskatchewan, Saskatoon, Canada
Eur J Pharm Biopharm 75:311-20. 2010..measurements were used to characterize the plasmid-gemini (PG) and plasmid-gemini surfactant-helper lipid (PGL) complexes. Gene expression was found to increase up to 72h and then declined by the 7th day...
- Primary gastric lymphomaTariq Parvez
Department of Oncology, King Fahad Hospital, Madina Munawra, KSA
J Coll Physicians Surg Pak 17:36-40. 2007To evaluate the clinico-pathological status of Primary Gastric Lymphoma (PGL) at presentation in King Fahad Hospital, Madina Munawra, Kingdom of Saudi Arabia (KSA).
- Lack of symptoms in patients with histologic evidence of pheochromocytoma: a diagnostic challengeDebbie L Cohen
Renal Electrolyte and Hypertension Division, Department of Surgery, University of Pennsylvania, 210 White Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Ann N Y Acad Sci 1073:47-51. 2006..neurofibromatosis type 1, two had von Hippel-Lindau disease, one had multiple endocrine neoplasia 2A, and one PGL/SDHD genetic mutation. Twenty-six patients had sporadic tumors or had not had genetic testing...
- Vancomycin pharmacokinetics and pharmacodynamics during short daily hemodialysisBrian S Decker
Indiana University School of Medicine, Indianapolis, IN, USA
Clin J Am Soc Nephrol 5:1981-7. 2010Short daily hemodialysis (SDHD) is an alternative to thrice-weekly HD because of its putative physiologic benefits. The purpose of this study was to investigate the effect of SDHD on the pharmacokinetics and pharmacodynamics of vancomycin.
- Inhibition of thymidylate synthase by pergularinine, tylophorinidine and deoxytubulosineK N Rao
Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Mumbai, India
Indian J Biochem Biophys 36:442-8. 1999..thymidylate synthase (TS) purified in our laboratory from Lactobacillus leichmannii was inhibited by pergularinine (PGL) and tylophorinidine (TPD) and deoxytubulosine (DTB) isolated from the Indian medicinal plants Pergularia pallida ..
- High-throughput screening for growth inhibitors using a yeast model of familial paragangliomaIrina Bancos
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
PLoS ONE 8:e56827. 2013..A remarkable puzzle is therefore presented by familial paraganglioma (PGL), a neuroendocrine cancer where the tumor suppressor genes encode subunits of succinate dehydrogenase (SDH), an ..
- Genetics and biology of pheochromocytomaM Mannelli
Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
Exp Clin Endocrinol Diabetes 115:160-5. 2007..The genes currently known to be responsible for tumor formation are RET, VHL, NF1, SDHB, SDHC and SDHD. Germline mutations of these genes increase the risk of developing pheochromocytomas and/or paragangliomas which ..
- A large deletion in the succinate dehydrogenase B gene (SDHB) in a Japanese patient with abdominal paraganglioma and concomitant metastasisHitomi Kodama
Departments of Endocrine Surgery, Tokyo Women s Medical University, Tokyo, Japan
Endocr J 57:351-6. 2010..mutations in nuclear genes encoding two mitochondrial complex II subunit proteins, Succinate dehydrogenase D (SDHD) and SDHB, have been found to be associated with the development of familial pheochromocytomas and paragangliomas (..
- Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature agingJingzhou Huang
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
J Mol Biol 387:559-69. 2009..Mutations in the human SDHB, SDHC and SDHD genes are responsible for the development of paraganglioma and pheochromocytoma, tumors of the head and neck or the ..
- Intronic single nucleotide polymorphisms in the RET protooncogene are associated with a subset of apparently sporadic pheochromocytoma and may modulate age of onsetSarah R McWhinney
Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
J Clin Endocrinol Metab 88:4911-6. 2003Approximately 75% of pheochromocytomas are sporadic. Germline mutations in RET, VHL, SDHB, and SDHD have been shown to cause the 25% that are hereditary...
- The clinical phenotype of SDHC-associated hereditary paraganglioma syndrome (PGL3)Tobias Else
Department of Internal Medicine, Divisions of Metabolism Endocrinology and Diabetes T E, R J A, Molecular Medicine and Genetics J N E, V M R, and Gastroenterology E M S, Department of Human Genetics M L M, and Department of Otolaryngology Head and Neck Surgery H A A at the University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109 and Norris Cancer Center S B G, University of Southern California, Los Angeles, California 90033
J Clin Endocrinol Metab 99:E1482-6. 2014..Although the phenotypes associated with the more commonly mutated genes, SDHB and SDHD, are well described, less is known about SDHC-associated paragangliomas.
- Novel dual-binding function of a poly (C)-binding protein 3, transcriptional factor which binds the double-strand and single-stranded DNA sequenceDuk Hee Kang
Division of Nephrology Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul 158 710, South Korea
Gene 501:33-8. 2012..plasmids expressing PCBP3 repressed the expression of luciferase reporters when cotransfected with single-strand (pGL-SS) and double-strand (pGL-DS) constructs containing poly(C) sequences in their promoters...
- Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complexEsther Perez
Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et Biologie Structurale, CNRS and Université Paul Sabatier Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse Cedex, France
J Biol Chem 279:42584-92. 2004..produce dimycocerosates of phthiocerol (DIM) and of glycosylated phenolphthiocerol, also called phenolglycolipid (PGL), two groups of molecules shown to be important virulence factors...
- Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neuronsM Leskiewicz
Department of Experimental Neuroendocrinology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
J Physiol Pharmacol 59:457-75. 2008..was to examine the effect of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), pregnenolone (PGL) and allopregnanolone (Allo) on staurosporine-, glutamate-, and NMDA-induced damage in primary cortical neuronal ..
- [The clinical implication of left ventricular hypertrophy in patients with pheochromocytoma and paraganglioma]Li Ding
Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Zhonghua Xin Xue Guan Bing Za Zhi 42:1029-34. 2014To explore the clinical implications of left ventricular hypertrophy (LVH) in patients with pheochromocytoma and paraganglioma (PH/PGL).
- [Nocturnal hemodialysis: an alternative treatment for a better quality of life]L Tartaglia
S C Nefrologia e Dialisi a direzione Universitaria, Azienda Ospedaliero Universitaria OO R R, Viale Luigi Pinto 1, Foggia, Italy
G Ital Nefrol 25:702-7. 2008..Alternative hemodialysis strategies including short daily hemodialysis (SDHD), long hemodialysis (LHD) and nocturnal daily hemodialysis (NDHD) have been developed in the hope to improve ..
- A high-resolution STS, EST, and gene-based physical map of the hereditary paraganglioma region on chromosome 11q23B E Baysal
Department of Human Genetics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Genomics 44:214-21. 1997..Most of the informative families appear to be linked to the distal locus on chromosome 11q23 (PGL1), which has been previously confined to a 2-cM interval by haplotype analysis in an extended Dutch pedigree...
- Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GITM Dubova
Sikl s Department of Pathology, Medical Faculty Hospital, Charles University, Plzen, Czech Republic
Histol Histopathol 30:223-32. 2015..Among the 11 KIT/PDGFRA wt GISTs, 6 expressed SDHB, 1 of them harboring a sequence change of SDHD. All SDHB-negative cases were SDHB-D wt...
- Vascular pattern analysis for the prediction of clinical behaviour in pheochromocytomas and paragangliomasLindsey Oudijk
Department of Pathology, Erasmus MC Cancer Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
PLoS ONE 10:e0121361. 2015..Currently, there are no generally accepted markers for identifying a primary PCC or PGL as malignant. In 2002, Favier et al...
- [Histopathological examination of Buruli ulcer (Mycobacterium ulcerans disease) in surgically removed skin]Satoyo Wakai
Division of Research and Examination, National Hospital Organization Nishisaitama Chuo National Hospital, Saitama, Japan
Nihon Hansenbyo Gakkai Zasshi 80:269-74. 2011..M. ulcerans was positive in a Fite stain and in a PGL-1 immunohistological stain. Based on these cases, we discuss the histological characteristics of Buruli ulcer.
- Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paragangliomaD Astuti
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, United Kingdom
Am J Hum Genet 69:49-54. 2001..Recently, pheochromocytoma susceptibility has been associated with germline SDHD mutations...
- Pathological mechanisms and parent-of-origin effects in hereditary paraganglioma/pheochromocytoma (PGL/PCC)Ulrich Muller
Institut fur Humangenetik, Justus Liebig Universitat, Giesen, and bio logis, Zentrum für Humangenetik, Frankfurt aM, 35392 Giessen, Germany
Neurogenetics 12:175-81. 2011..Mutations in genes encoding the small subunits of SDH, i.e., SDHD and SDHC, cause PGL1 and PGL3...
- A probabilistic assessment of the diagnosis of paraganglioma/pheochromocytoma based on clinical criteria and biochemical/imaging findingsIoannis Ilias
Department of Nuclear Medicine, Hippokration General Hospital, Konstantinoupoleos St 49, P C 546 42, Thessaloniki, Macedonia, Greece
Hell J Nucl Med 18:63-5. 2015Paragangliomas (PGL) and pheochromocytomas (P) are rare neural-crest-derived neoplasms. Very recently guidelines on diagnosis and treatment of PGL/P have been presented by the US Endocrine Society...
- Recent advances in the genetics of phaeochromocytoma and functional paragangliomaAnne Paule Gimenez-Roqueplo
Paris Descartes University, Paris, France
Clin Exp Pharmacol Physiol 35:376-9. 2008..genetic studies have now shown that 25-30% of patients have hereditary PH due to a germline mutation in the SDHB, SDHD, VHL, RET or NF1 gene and that the identification of a germline SDHB mutation is associated with a high risk of ..
- Primary duodenal follicular lymphoma: 6-years complete remission after combined radio-immunotherapyPierfrancesco Franco
Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, Ospedale S Giovanni Battista, Turin, Italy
Acta Gastroenterol Belg 74:337-42. 2011Primary gastrointestinal lymphoma (PGL) is known to account for 40% of all extranodal non-Hodgkin's lymphomas (NHLs) and between 4% to 12% of all NHLs...
- High rates of undiagnosed leprosy and subclinical infection amongst school children in the Amazon RegionJosafá Gonçalves Barreto
Laboratório de Dermato Imunologia, Universidade Federal do Para, Marituba, PA, Brasil
Mem Inst Oswaldo Cruz 107:60-7. 2012..6), were diagnosed with leprosy and 777 (48.8%) were seropositive for anti-phenolic glycolipid-I (PGL-I). Additionally, we evaluated 256 house-hold contacts (HHCs) of the students diagnosed with leprosy; 24 (9...
- The role of complex II in diseaseAttje S Hoekstra
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Biochim Biophys Acta 1827:543-51. 2013..gene mutations, in both succinate dehydrogenase and associated accessory factor genes (SDHA, SDHB, SDHC, SDHD, SDHAF1, SDHAF2), have been identified over the last 12 years and include hereditary paraganglioma-..
- Penetrance and clinical consequences of a gross SDHB deletion in a large familyD C Solis
Reproductive and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
Clin Genet 75:354-63. 2009..SDHB) are inherited in an autosomal dominant manner and are associated with hereditary paraganglioma (PGL) and pheochromocytoma. The phenotype of patients with SDHB point mutations has been previously described...
Research Grants37
- Molecular Basis of Familial ParagangliomaLOUIS JAMES MAHER; Fiscal Year: 2013..Though often helpful, this analogy completely fails in the fascinating case of familial paraganglioma (PGL)...
- Understanding the epigenetic basis of human familial paragangliomaYENG FRANSOUA HER; Fiscal Year: 2013..Specifically, we study familial paraganglioma (PGL), a neuroendocrine cancer, as a model that exemplifies metabolic derangement...
- Epigenetic Regulation of Mitochondiral Complex IIGerald S Shadel; Fiscal Year: 2010..Mutations in the smallest subunit of complex II, encoded by a gene named SDHD, are the primary cause of head and neck paragangliomas...
- Role of Hypoxia-Induced miR-210 in Tumor MetabolismMircea Ivan; Fiscal Year: 2013..targets with functions in the mitochondrial electron transport: ISCU (Iron Sulfur Cluster Scaffold Homolog), SDHD (succinate dehydrogenase subunit D) and NDUFA4 (subunit of the NADH-ubiquinone oxidoreductase complex)...
- Modulation of Human Immunity by Mycobacterium lepraeCLAUDIA M A MANCA; Fiscal Year: 2013..Exposure of na[unreadable]ve cells to M. leprae or its cell wall phenolic glycolipid PGL-1 induces a very weak pro-inflammatory Th1 type cytokine response and the robust production of down-regulatory ..
- SEROLOGIC DETERMINATION OF LEPROSY IN CHIMPANZEESBobby Gormus; Fiscal Year: 1992..to determine the titers of IgG and IgM antibodies to Mycobacterium leprae-specific cell wall phenolic glycolipid-I (PGL-I) antigen and the mycobacterial common cell wall antigen lipoarabinomannan (LAM)...
- METABOLIC MAINTENANCE & GROWTH OF MYCOBACTERIUM LEPRAEScott Franzblau; Fiscal Year: 1992..assays: a) quantitation of intracellular adenosine triphosphate (ATP), b) incorporation of 14C-palmitate into PGL-1, c) measurement of the rate of 14CO2 released from 14C- palmitate...
- Mycobacterial PDIM/PGL: synthesis pathway and inhibitionLUIS E QUADRI; Fiscal Year: 2010..studies will investigated several hypothesized steps in DPK synthesis and explore the development of a first PGL synthesis inhibitor...
- N-Linked Protein Glycosylation: Pathways and ProcessesBarbara Imperiali; Fiscal Year: 2013..the overall processes that support the hypothesis that the detailed study of the prokaryotic protein glycosylation (pgl) pathway of C...
- DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung EpitheliumHua Zhao; Fiscal Year: 2009..this goal, we will apply host cell reactivation (HCR) assay to quantify DRC of BPDE induced DNA adducts in plasmid pGL-3-luc in lymphocytes reflecting systemic NER capacity...
- Mechanisms of Metabolic Gene Mutations in CancerYue Xiong; Fiscal Year: 2013..are frequently mutated in human cancer, including fumarate hydratase (FH), succinate gehygrogenase (SDHB, SDHC, SDHD and SDH5), and isocitrate dehydrogenase-1 and -2 (IDH1, IDH2)...
- RNA protection and decay in yeast mitochondriaCAROL DIECKMANN; Fiscal Year: 2009..Overexpression of the Cbt1 protein suppresses mRNA instability, whereas deletion of the CBT1 gene results in defective processing of precursor ..
- Effect of different hemodialysis modalities on hepatic CYP450 metabolismBRIAN SCOTT DECKER; Fiscal Year: 2013..Short-daily hemodialysis (SDHD) is an emerging modality that provides two-hour hemodialysis (HD) sessions, 6 days a week...
- Probing the Glycan Biosynthetic Machinery of Campylobacter Jejuni.JERRY TROUTMAN; Fiscal Year: 2009..and the potential interactions of this enzyme with other proteins in the oligosaccharide donor biosynthesis (or Pgl) pathway...
- Expression of Human Therapeutic Proteins in Transgenic Tobacco ChloroplastsHenry Daniell; Fiscal Year: 2010..functional, and structural studies;e) Create a chloroplast capable of glycosylation of a foreign protein using the pgl operon...
- BRAIN TARGETING OF THYROTROPIN RELEASING HORMONE ANALOGSLaszlo Prokai; Fiscal Year: 2002..be improved by using alpha-hydroxyglycine to achieve carboxy-terminal amidation via peptidylamidoglycolate lyase (PGL, EC 4.3.2...
- STRUCTURE OF THE ANTIGENS OF ATYPICAL MYCOBACTERIAPatrick Brennan; Fiscal Year: 1980..The immunogenicity of these will be examined in the hope of preparing monospecific antisera. The possibility that the PGL antigens of MAIS serovars are the products of lysogenic conversion will also be explored.
- Components of C. elegans P-granules and regulation of their functionEkaterina Voronina; Fiscal Year: 2009..elegans expressing a GFP fusion to the germ granule component PGL-1, and an RNAi library targeting -3,000 genes expressed preferentially in the female germline...
- AIDS-ASSOCIATED HEART DISEASE--INCIDENCE ETIOLOGYMelvin Cheitlin; Fiscal Year: 1992..I - HIV seropositive, asymptomatic infection Group II- Hiv seropositive, persistent generalized lymphadenopathy (PGL) Group III- Aids patients Group IV- Age-matched, clinically-well, HIV seronegative, homosexual men (controls for ..
- Host-Pathogen Interactions and M.tb Drug ResistanceGilla Kaplan; Fiscal Year: 2009..tuberculosis phenol glycolipid (PGL-tb), which induces a host immune response that fails to control bacillary growth efficiently, is therefore ..
- NEUROPEPTIDES--APPROACH TO AMIDATION EFFECTORSSHELDON MAY; Fiscal Year: 1999..The second enzyme, peptidylamidoglycolate lyase (PGL) ---first reported by our laboratory--catalyzes dealdylation of the a- hydroxyglycine derevatives to produce the ..
- Human T Cell Antigens of Mycobacterium tuberculosisSteven Reed; Fiscal Year: 2009..Finally, we will test antigens/vaccine formulations in rodent models of infection and disease. By the end of the funding period, we will have defined a second vaccine candidate for entry into clinical trials. ..
- OXYGEN SENSING AND CELL SIGNALING IN HYPOXIAPaul Schumacker; Fiscal Year: 2001..These studies will identify a novel pathway of cellular O2 detection, and may help clarify understanding of how cells adapt to lowered O2 conditions. ..
- Genetic Etiologies of Esophageal Barrett's and CancerCharis Eng; Fiscal Year: 2003..This might facilitate molecular diagnostics and early prediction as well as targeted surveillance and prophylaxis. ..
- RET RECEPTOR POLYMORPHISMS & HIRSCHSPRUNG DISEASECharis Eng; Fiscal Year: 2004..Finally variants found to be associated with disease status will be tested functionally at the transcript, protein and cell biological level. ..
- Using Synthetic Lethality to Select Cancer Drug TargetsWilliam Kaelin; Fiscal Year: 2005..Moreover, they may establish a new paradigm for the selection of anticancer drug targets based on inactivating mutations of TSG. ..
- Identify Waardenburg syndrome type 2 loci in manJEFFREY MILUNSKY; Fiscal Year: 2005..We will perform a high-density genome scan coupled with linkage disequilibrium analyses on 3 large multigenerational families and multiple smaller families with WS2 to identify candidate gene(s) with mutations causing WS2. ..
- Development & Manufacture of an MDR Tuberculosis VaccineSteven Reed; Fiscal Year: 2005..This will enable us to immediately proceed to human clinical trials after the end of the funding period. ..
- Identify genes causing Kabuki SyndromeJEFFREY MILUNSKY; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- O2 SENSING BY MITOCHONDRIA DURING INTERMITTENT HYPOXIAPaul Schumacker; Fiscal Year: 2003..Collectively, these studies could identify a novel mechanism of O2 sensing in the lung, and provide a mechanistic explanation for the activation of gene transcritpion and cellular proliferation during intermittent hypoxia. ..
- Nitric oxide and mitochondrial biogenesis in sepsisClaude A Piantadosi; Fiscal Year: 2010..abstract_text> ..
- Real-Time Imaging of Hypoxia based on VHL ActivityWilliam Kaelin; Fiscal Year: 2006..unreadable] [unreadable]..
- 2006 Cancer Model MechanismsWilliam Kaelin; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Lung Injury Protection by Coagulation BlockadeCLAUDE PIANTADOSI; Fiscal Year: 2008..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
- O2 Sensing in Hypoxic Pulmonary VasoconstrictionPaul Schumacker; Fiscal Year: 2009..Collectively, these studies will test whether a common O2 sensing mechanism functions in PA myocytes and endothelial cells to trigger their diverse responses in HPV. ..
- A Luciferase Fusion Protein Library to Identify & Monitor Ubiquitylation TargetsWilliam Kaelin; Fiscal Year: 2008..Reisolation of HIF in aims 2 and 3 would constitute proof of concept with respect to the potential utility of this approach. ..


text:
Spalding becomes Europe's biggest pumpkin patch
1 October 2010 Last updated at 09:05 BST
The Lincolnshire town of Spalding has become the biggest pumpkin patch in Europe with a bumper crop this year.
Each pumpkin has to be cut by hand and only a tiny proportion of them will be eaten.
Anthony Bartram reports.


text:
Hostal GC Ciudad Encantada
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Viva Madrid!
... I was thoroughly tired from a fun but exhausting weekend.
Now it is Monday morning and I am off to start classes for another week, to be followed up by next weekend traveling to Munich, Germany for the famous Oktoberfest! Hasta luego!
Note: As crazy as the bull run sounds, it is an important part of Spanish culture and in the whole day I only saw one person get hurt by the bull. To Americans the bull run is a little weird, but I am glad I was able to see it for myself.
Exploring Cuenca
... stop (red) go (green) light system to ensure the traffic only flows one way at a time. In Plaza Mayor they are setting up a big stage and installed oversized metal posts and timber rails to corral people, it seems they have they have big festival on, from the picture I saw we can expects thousands of people to be jammed into Plaza Mayor tonight. Have returned to our room to start packing for an early departure, back to Madrid to drop the car off and catch a flight to ...
Long drive
After a rather pleasant walk down through the forest below the Alhambra we arrived back at our hotel a bit before 2:00pm. Much earlier than it would have been if we had waited for the bus to take us back! I ducked up to the car parking garage to fetch the car, yesterday afternoon the police were blocking off access to the front of our hotel so I was concerned they might do this each day (our hotel is next to a large police station). ...
... explains it :-)
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Ciudad Encantada / Enchanted city
I drove to nature park Ciudad Encantada, about 45 minutes from Cuenca. It was just a small side note in my guidebook, not even one of this province's highlights. But ...
Day 4
... in raincoats we cycled in the heavy rain and actually quite cold conditions, stopping only for the very necessary haribo breaks, one of which took place in the sanctuary of a church. Lunch offered a new challenge. As we were about to sit down on some benches in a little picturesque village we were approached by an old lady whom we assumed was telling us off in Spanish. She disappeared back into her ...


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Very nice. I particularly like the picture of the pumila "Icee" or is it a "Slurpee" <grin>
Hello, everyone! A new pumila seedling of mine bloomed for the first time last week. It is a cross of my pumila seedling 2-8 X 'Burst of Blue'. "BofB" is a pumila from the Willotts that was registered as an MDB. My seedling is a pretty little thing, 4 and 1/2" tall, and here are 3 photos. The first 2 photos were taken on April 1; the third was taken on April 2. It survived the April 2 weather just fine! Elm <(Jpum2-8%20X%20'Burst%20of%20Blue')%20fig.1.JPG> <(Jpum2-8%20X%20'Burst%20of%20Blue')%20fig.2.JPG><IMG_6400.JPG> <(Jpum2-8%20X%20'Burst%20of%20Blue')%20fig.1.JPG><(Jpum2-8%20X%20'Burst%20of%20Blue')%20fig.2.JPG><IMG_6400.JPG>


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A GIF on the home page of the New Yorker? Clearly reblogs and salutations are in order.
Here at the Daily Dot, we swap GIF images with each other every morning. Now we're looping you in. In the Morning GIF, we feature a popular—or just plain cool—GIF we found on Reddit, Canvas, or elsewhere on the Internet.
On Friday the venerated New Yorker featured a GIF on its home page.
Congratulations, respect, likes and reblogs are due to artist Kris Mukai, the first to break the digital class barrier on behalf of our favorite animation format. Her image of a sweet moppet popping out of a coffee cup illustrates a story on the currently fashionable "Babycchino."
This is a trend now?
I blame Howard Schultz.
This spider-tailed snake is the very definition of 'nope'
Not only is evolution a fact, that shit is fucked up: Less than a decade ago, scientists stumbled across Pseudocerastes urarachnoides, or the spider-tailed horned viper—an Iran-dwelling species with a crafty and horrifying method for attracting prey.
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