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An interdisciplinary Liver Research Center was established at the Albert Einstein College of Medicine in 1974 with support from NIDDK. At present, 38 faculty investigators and 3 provisional investigators in 12 departments at the medical school, together with 12 Consultants/Collaborators and 5 Supporting Staff Faculty at AECOM, constitute the Liver Research Center. The major objective is to understand fundamental mechanisms of normal liver function, as well as alterations in these function resulting from diseases caused by metabolic, drug, inheritable and infectious (viral) agents. Specific areas under study include transport processes, membrane receptor biology, and structural-functional relationships;molecular biology, somatic gene transfer and gene therapy and mechanisms of hepatic carcinogenesis;hepatic cell transplantation and liver repopulation;liver cell metabolism, mechanisms of liver injury and organelle pathology. By bringing excellent basic scientists into disease related research, together with hepatologists interested in fundamental mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. The Center is the focus of an active research-oriented education program (research seminars, visiting scientists, pathobiology sessions and work-in-progress discussion groups), and has extensive collaborative studies with investigators in other institutions. Core facilities, including Molecular Biology and Genetics, Cell Culture and Genetic Engineering, Imaging and Cell Structure, Special Animals and Administrative, efficiently facilitate interdisciplinary research projects. Facilities include 38 well-equipped laboratories for major investigators, 5 core facilities, Animal Institute, and all institutional support services (library, engineering, computer center, etc.). The available clinical facilities include a 1100 bed general hospital (Bronx Municipal Hospital Center), Montefiore Hospital (729 beds) and the Jack D. Weiler Hospital of Albert Einstein College of Medicine (375 beds). A large and diverse patient population provides many individuals with viral, alcoholic and parasitic live disease, as well as various inheritable disorders of the liver. The Center is directed by the Principal Investigator (Dr. David A. Shafritz) and Associate Director (Dr. Allan W. Wolkoff), governed by an Executive Committee, advised and reviewed by a Scientific Advisory Committee and functions through several school-wide committees. The Center was officially chartered by the medical school in 1977 as a free standing, extra- and supra-departmental entity. The importance of the Liver Research Center to the College of Medicine has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by the previous Dean, Dominick P. Purpura, M.D. and the present Dean. Allen Spiegel, M.D.
|Lim, Jihyeon; Liu, Zhongbo; Apontes, Pasha et al. (2014) Dual mode action of mangiferin in mouse liver under high fat diet. PLoS One 9:e90137
|Wang, Wen-Jun; Murray, John W; Wolkoff, Allan W (2014) Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins. Drug Metab Dispos 42:62-9
|Yovchev, Mladen I; Xue, Yuhua; Shafritz, David A et al. (2014) Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes. Hepatology 59:284-95
|Yuan, Fei; Snapp, Erik L; Novikoff, Phyllis M et al. (2014) Human liver cell trafficking mutants: characterization and whole exome sequencing. PLoS One 9:e87043
|Mukhopadhyay, Aparna; Quiroz, Jose A; Wolkoff, Allan W (2014) Rab1a regulates sorting of early endocytic vesicles. Am J Physiol Gastrointest Liver Physiol 306:G412-24
|Viswanathan, Preeti; Kapoor, Sorabh; Kumaran, Vinay et al. (2014) Etanercept blocks inflammatory responses orchestrated by TNF-? to promote transplanted cell engraftment and proliferation in rat liver. Hepatology 60:1378-88
|Bahde, Ralf; Kapoor, Sorabh; Gupta, Sanjeev (2014) Nonselective inhibition of prostaglandin-endoperoxide synthases by naproxen ameliorates acute or chronic liver injury in animals. Exp Mol Pathol 96:27-35
|Rogler, Leslie E; Kosmyna, Brian; Moskowitz, David et al. (2014) Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia. Hum Mol Genet 23:368-82
|Lajoie, Patrick; Fazio, Elena N; Snapp, Erik L (2014) Approaches to imaging unfolded secretory protein stress in living cells. Endoplasmic Reticulum Stress Dis 1:27-39
|Kapoor, Sorabh; Berishvili, Ekaterine; Bandi, Sriram et al. (2014) Ischemic preconditioning affects long-term cell fate through DNA damage-related molecular signaling and altered proliferation. Am J Pathol 184:2779-90
Showing the most recent 10 out of 252 publications


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SNAG stands for "Starting New at Golf." SNAG is designed to introduce new people to the sport, and is a fun and easy way to learn to play golf at any age. Recently, the city of Loveland, Colo., constructed a new type of course to make it easier for new participants to try out the sport without the barriers associated with a regulation golf course. In this 90-minute webcast, Steve Southard, CGCS, will present a case study on the Cattail Creek Mini-Course. The mini-course is a nine-hole facility that combines a nine-hole real grass putting course with nine holes of SNAG-friendly golf. The putting course aspect of the new course is exactly as it sounds -- a real grass golf course played only with a putter. The SNAG-friendly portion of the course is integrated seamlessly into the putting course and incorporates the use of special SNAG equipment. Southard will explain how this new facility has impacted golf in his community.
Original presenation date: Oct. 23, 2013
Steve Southard, CGCS, is the golf operations manager for the city of Loveland. He is also the president of Pace and Production LLC, a golf course training and consulting company that specializes in pace of play and increasing revenue. Southard has taught at the GCSAA Education Conference and helped develop a GCSAA online course on pace of play. He is also working closely with the USGA on its new Pace of Play Initiative.
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A jury trying a father and his son over the deaths of two firemen following a massive explosion at a fireworks factory retired to consider its verdicts today.
Retained firefighter Geoff Wicker, 49, and support officer Brian Wembridge, 63, were killed in the blast at Festival Fireworks UK Ltd at Marlie Farm in Shortgate, near Lewes, East Sussex, on December 3, 2006.
Jurors at Lewes Crown Court have heard that a metal container illegally packed with fireworks capable of causing a mass explosion went off "like a bomb", hurling fragments far and wide.
As well as killing the two firemen, both long-serving members of East Sussex Fire and Rescue Service, the blast injured 20 other people, mostly police and fire officers.
It is alleged that the potential for a mass explosion was obvious to Martin Winter, 52, the owner of the company, now called Alpha Fireworks Ltd, and his son and employee, Nathan Winter, 25.
Prosecutors claim the Winters were both familiar with the different hazard classifications given to fireworks and their potential for mass explosion in a confined steel container.
It is also alleged that both men were familiar with the licence and its obligations about how and what could be stored, and how fireworks should be handled.
The Winters, who live on Marlie Farm, both deny two counts of manslaughter.
Not guilty pleas have also been entered on behalf of the company, which faces two counts of breaching health and safety legislation.
Jurors have heard that the Winters could not be considered responsible for the two deaths as it was the duty of fire officers at the scene to be aware of the dangers of a blaze involving fireworks and to take the necessary precautions.
It was also suggested during Nathan Winter's evidence that his concerns to keep the flames away from the container were not taken seriously enough by fire officers.
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4 trees removed from Bluebird Canyon replacement plan
Some Bluebird Canyon residents don't have to worry about the city of Laguna Beach planting trees near their homes.
The City Council voted 5-0 on Tuesday night to remove four trees from a proposed planting plan after residents voiced view and fire concerns.
In the past year, 11 city-maintained eucalyptus trees were removed due to disease and safety concerns in the canyon, which is known for its rural atmosphere and eucalyptus-aided shade.
The council decided last year to put replacement trees at safe locations near the removal sites. However, some of the locations were near homes that previously didn't have trees, creating an outcry.
California sycamores and coast live oaks are the replacements, a city staff report said.
Supporters said all 13 proposed replacement trees should be OKd in an effort to keep Bluebird Canyon a wooded area.
The city proposed five replacement trees in the neighborhood and eight above the reservoir and tennis courts, also called the "horseshoe" area near Bluebird Canyon Drive and Rancho Laguna.
Resident Sue Kempf agreed to have a tree at her property, and it will be the only planting near a home. The eight others didn't spark debate and were OKd by the City Council.
About a dozen Bluebird Canyon residents spoke Tuesday.
"I'm not keen on putting a bunch of trees in the canyon because, you know, working on the Disaster Preparedness Committee I'm not a fan of a lot of fuel up there," Kempf said.
A couple of residents said the issue is "keeping the integrity of the neighborhood" and that view discussion shouldn't be part of it.
The city reported a budget of $30,000 for the replacement tree program, which includes 90 days of maintenance and trimming.
Contact the writer: 949-492-5135 or email@example.com
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RHA provides a wealth of information and top of the line services to rental housing providers across the State of Washington. We believe you will find the value of an RHA membership is unmatched anywhere else.
The Rental Housing Association prides itself on being a one-stop shop. Over 5,100 members already call RHA home. Our friendly and professional staff are here Monday through Friday to provide you with the critical information and resources you need to help run your rental business. Whether you have a single family home for rent, or more than a hundred units, the challenges for rental housing providers are mounting daily. We are here to help.
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5 CFR 890.1031 - Grounds for suspension.
(a)Basis for suspension. OPM may suspend a provider if:
(1) OPM obtains reliable evidence indicating that one of the grounds for suspension listed in paragraph (b) of this section applies to the provider; and
(2) The suspending official determines under paragraph (c) of this section that immediate action to suspend the provider is necessary to protect the health and safety of persons covered by FEHBP.
(b)Grounds for suspension. Evidence constituting grounds for a suspension may include, but is not limited to:
(1) Indictment or conviction of a provider for a criminal offense that is a basis for mandatory debarment under this subpart;
(2) Indictment or conviction of a provider for a criminal offense that reflects a risk to the health, safety, or well-being of FEHBP-covered individuals;
(3) Other credible evidence indicating, in the judgment of the suspending official, that a provider has committed a violation that would warrant debarment under this subpart. This may include, but is not limited to:
(i) Civil judgments;
(ii) Notice that a Federal, State, or local government agency has debarred, suspended, or excluded a provider from participating in a program or revoked or declined to renew a professional license; or
(iii) Other official findings by Federal, State, or local bodies that determine factual or legal matters.
(c)Determining need for immediate action. Suspension is intended to protect the public interest, including the health and safety of covered individuals or the integrity of FEHBP funds. The suspending official has wide discretion to decide whether to suspend a provider. A specific finding of immediacy or necessity is not required to issue a suspension. The suspending official may draw reasonable inferences from the nature of the alleged misconduct and from a provider's actual or potential transactions with the FEHBP.
Title 5 published on 2015-12-02
The following are ALL rules, proposed rules, and notices (chronologically) published in the Federal Register relating to 5 CFR Part 890 after this date.
Title 5 published on 2015-12-02.
The following are only the Rules published in the Federal Register after the published date of Title 5.
For a complete list of all Rules, Proposed Rules, and Notices view the Rulemaking tab.


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On the one hand, at the local level, there is a renewal of battles over school and welfare rights, assuming greater importance in the face of Washington's transfer of its responsibilities down to the states. California offers a mirror to what may hold for the rest of the US with the recent decision to end bilingual education. But of equal importance has been the continuing strength of the cultural/moral conflict. Value politics rule when political debate becomes de-ideologised, and focused on the consensual centre ground of low taxes, support for "entitlements" and a pro-business environment. This has magnified the cultural differences between liberals and conservatives. One recent study by Alan Woolf suggests that Americans are far more tolerant than even they themselves suspected. He confirms the dislike the majority display towards politicised religion, suggesting it extends even into the southern Bible belt. Indeed, most Americans are more tolerant and non-judgmental about women's rights, civil rights and religious diversity, and adopt a "live and let live" philosophy in which they seek a middle way through life's complexities.
One obvious beneficiary of this more relaxed moral stance has been the President, lauded for his success in sustaining economic growth, while his moral behaviour is viewed as his own affair. The Progressivism of the future may turn out to be more associated with moral and social attitudes rather than an economic policy of redistribution.
Division of Politics
South Bank University
London SE1
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text: Posted March 8, 2013 scan of a publicity photo of COPPELIA, Act 1, with Dayde in the center of the group, presumably in the "Ballade de l'Epi" - the caption doesn't identify the dancer performing Frantz, who is perhaps seen cut off on the right edge of the photo with his hand to his ear. maybe BA members familiar with French dancers of the period can suggest who this might be. Share this post Link to post


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Serologic autoimmunologic parameters in women with primary ovarian insufficiency
© Zhen et al.; licensee BioMed Central Ltd. 2014
Received: 1 September 2013
Accepted: 28 February 2014
Published: 10 March 2014
Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters.
The serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren's syndrome A (SSA/Ro), Sjogren's syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA),Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA)were analyzed.
Among the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups.
This study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined.
KeywordsPrimary ovarian insufficiency Antibody Immune Microarray Premature ovarian failure
In the normal course, a woman enters menopause at a mean age of 51 years (41-60 years). However, early menopause occurs approximately 1% of women before 40 years of age, approximately 0.1% of women under 30 and 0.01% of women younger than 20. This condition is termed as premature ovarian failure (POF), also referred to as primary ovarian insufficiency (POI), characterized by amenorrhea, sex steroid deficiency and elevated levels of gonadortropins. The etiologies include genetic causes, enzymatic and gonadotropin defects, ovarian insults, and autoimmunity. Approximately 20-30% of the cases with POI have associated autoimmune disorders [1]. A variety of auto-immune conditions such as endocrinopathy, thyroid diseases, addision's disease, rheumatoid arthritis and polyglandular syndrome have been found in POI women.
A number of autoimmunologic diseases exhibit circulating characteristics. Antibodies to thyroid microsomal [2] and myeloperoxidase (MPO) are associated with graves' disease and thyroiditis [3], antinuclear antibodies (ANA) and rheumatoid factor(RF) represent a serology hallmark in the diagnosis of systemic autoimmune rheumatic disease (SARD) such as systemic lupus erythematosus [4]. Zona pellucida antibodies are associated with POI, antibodies to double-stranded DNA (ds-DNA), histone, nuclear ribonucleoprotein (RNP) and Smith antigen [5] are associated with SLE, whereas antibodies to Sjogren's syndrome A (SSA/Ro) and Sjogren's syndrome B(SSB/La) can occur in both SLE and Sjogren's syndrome (SS). Antibodies to MPO and proteinase 3 (PR3) have been demonstrated to mediate anti-neutrophil cytoplasmic antibody (ACNA)-associated disease which is the target of anti-neutrophil cytoplasm antibodies in granulomatosis with polyangiitis [6]. Antibodies to Jo-1 was observed in polymyositis and dermatomyositis, whereas antibodies to scleroderma-associated antigen (Scl-70) and centromere can occur in patients with progressive systemic sclerosis (PSS) [7]. Anti-glomerular basement membrane antibody is associated with glomerulonephritis [8]. Anti-RNP antibodies are linked with mixed connective tissue disease (MCTD) and SLE, anti-PCNA antibodies have been described in a variety of SARD.
The aim of the present study was to investigate a panel of serologic autoimmunologic parameters in POI women and contributed further data on autoimmunologic processes and to elucidate potential mechanisms for their interrelation in POI.
Selection criteria of patients and controls
A total of 96 patients and 100 controls were included in this study. A written consent was obtained from all patients and controls for their participation in the study. All of the procedures were carried out in compliance with the Declaration of Helsinki. This study was approved by the Peking University Third Hospital ethical committee (IRB00006761-2011022, about the details of the ethics statement please see the Additional file 1).
The inclusion criteria were (1) age <40 years, (2) amenorrhea for > 6 months, (3) FSH > 40IU/L (two times apart more than one month), (4) chromosome Karyotype is 46 XX. Control subjects were enrolled by the criteria (1) age-matched with the POI group, (2) menstrual rules, (3) hormone level was normal. None of them had a personal or family history of hereditary disease and pelvic surgery and no radiation and chemotherapy histories (such as previous pelvic irradiation, operative castration, and previous cytotoxic chemotherapy were excluded).
Blood was collected from the recruited individuals, serum separated, stored at -20°C till further use.
Detection of antibodies
A protein microarray-based detection kit (CapitalBio, Beijing) was used, 18 antigens related with the serum autoimmune antibodies were immobilized on the microarray. The principle is to carry out a relative quantitative detection on the related antibodies using an indirect immunofluorescence assay on the chip. First of all, on-chip fixed antigens were reacted with lgG antibodies in the serum sample to form antigen - antibody complexes. The quantity of the antigen - antibody complex depends on the amount of specific lgG antibodies in serum. Then add excessive amount of Cy3 fluorescent labeled anti-human lgG antibody (secondary antibody) to the microarray which will interact with the complex to form the antigen-antibody-fluorescent-antibody complex, and the amount of the antigen-antibody-fluorescent-antibody complex on the array depends on the amount of antigen-antibody complex. The microarray was scanned by LuxScan 10K-B microarray scanner to detect the fluorescence signals on the array to form an image. Finally, the data was analyzed by the interpreted software on the machine and the serum concentrations of specific antibody were calculated.
Data was analyzed using a cutoff value to determine an antibody positive result. The cutoff value was equivalent to the mean value for the serum assay controls (n = 100) plus 2SD (95% CI) or 3SD (99% CI).
Statistical analysis
Quantitave data were expressed as mean ± SD, T-test and chi-square or Fisher exact test were used to compare hormone serum levels, BMI, ovarian volume and antibodies. All tests applied two-tailed, and the significance level was defined as p value < 0.05. Statistical analysis was performed with the SPSS 11.5 package.
Characteristics of the POI and health control women
POI (Range) N = 96
Health (Range) N = 100
Age (year)
27.6 ± 4.51 (21-38)
27.5 ± 4.57 (21-39)
Menarche (age)
13.5 ± 1.71 (12-18)
13.4 ± 1.15 (12-15)
Amenorrhea (year)
6.33 ± 4.71 (2-18)
BMI (kg/m2)
20.5 ± 2.12 (16-27)
20.33 ± 1.56 (18-25)
80.25 ± 33.6 (44.7-140.2)*
7.6 ± 1.74 (5.35-9.7)
38.65 ± 14.8 (20.4-89.7)*
4.29 ± 1.89 (2.89-9.56)
E2 (pmol/L)
80.4 ± 13.3 (73.4-109)*
136 ± 53.9 (96.9-240)
T (nmol/L)
0.781 ± 0.29 (0.69-1.28)**
1.32 ± 0.379 (1.21-2.19)
A (nmol/L)
5.46 ± 1.9 (2.5-6.7)
6.02 ± 1.97 (4.3-8.9)
Ovarian volume (ml)#
1.512 ± 2.01 (0.489-7.53)*
13.1 ± 1.61 (9.63-19.8)
Summarize of the laboratory findings in women characterized as autoimmune patients#
POI Women (n = 96)
Healthy women (n = 100)
P value
4.2 (4/96)
2 (2/100)
Sm (%)
10.4 (10/96)
6 (6/100)
10.4 (10/96)
2 (2/100)
26 (25/96)
15 (15/100)
7.3 (7/96)
4 (4/100)
2.1 (2/96)
2 (2/100)
19.8 (19/96)
14 (14/100)
11.5 (11/96)
8 (8/100)
1 (1/96)
1 (1/100)
2.1 (2/96)
1 (1/100)
14.6 (14/96)
2 (2/100)
8.3 (8/96)
6 (6/100)
10.4 (10/96)
8 (8/100)
8.3 (8/96)
5 (5/100)
3.1 (3/96)
3 (3/100)
2.1 (2/96)
1 (1/96)
4.2 (4/96)
3 (3/100)
The level of positivity of anti-PR3 and anti-JO-1 observed in POI patients have been presented in figures (see the Additional files 2 and 3).
Variety of possible causes of POI reflects the heterogeneity of POI. None of the causes seems to predominate. However, their true incidence in the majority of the cases of POI remains unclear, so the scientists working in this area should be focus on the etiology of POI [9]. Autoimmunity appears to play a role in some cases of POI. The study shows that POI women group have significant higher levels of Jo-1 and PR3 antibodies (p = 0.010 and p = 0.001) whereas the circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, CEN, ZP, AC, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups.
Autoimmune mechanisms are involved in the pathogenesis of up to 30% of cases in idiopathic POI [10]. It has been estimated that, in adult patients with POI, 18-30% also have an autoimmune disease and up to 50% have other evidence of autoimmunity [11]. The diagnosis of autoimmunity diseases relies on clinical, biological and histologic parameters. But in our study, all patients and healthy control women had no clinical symptom of autoimmunity disease. Detection of specific autoantibodies remains the most practical clinical research marker of any of autoimmune disease, so we selected a panel of well-established markers which are used in the diagnosis of autoimmunity diseases to investigate serologic autoimmunologic parameters in POI women. To our knowledge, no such data have been published in women with POI.
Human ovary is commonly the target of an autoimmune attack in cases of organ or non-organ specific autoimmune disorders leading to the ovarian dysfunction. Colafrancesco et al. described three clinical cases who developed premature ovarian failure following administration of the HPV vaccine [12]. Autoimmune etiology includes the presence of lymphocytic oophoritis, autoantibodies to ovarian antigens and associated autoimmune disorder. Anti-ovarian antibodies have been demonstrated in patients with SLE and primary Sogren's syndrome and polyglandular syndrome [13]. Autoimmunity is an important mechanism for accelerated destruction of ovarian follicles.
Development of ovarian auto-antibodies is a causative factor in most POI cases. Although controversial, the presence of circulating antiovarian antibodies (AOA) may be considered a marker of autoimmune premature ovarian failure. Vallotton and Forbes were the first to describe the presence of antibodies from POI serum. Prevalence of antibodies in POI patients varied among investigators from 24%-73.3%. Different antibody test format, antigen preparation and criteria for different studies and several antigenic targets lead to different results [14–17]. Wheatcroft et al. reported an incidence ranging from 24-60%, depending on the source of ovarian antigen [2]. Besides, one of the major drawbacks in the detection of ovarian antibodies in serum is the higher rate of false positives. ZP is an extracellular matrix that surrounds the mammalian oocyte and plays an important role in normal folliculogenesis and fertilization, so ZP could be an important ovarian antigen [18, 19]. Pires et al. indicated that several proteins from other cellular targets such as oocytes, corpus luteum, theca and granulose cells are also involved in ovarian autoimmunity [20]. In our study, with its strong immunogenicity and its possible relation with premature ovarian failure, we use the human ZP as antigen, but no difference was observed in the serum level of AOA between POI patients and control (11.5% & 8%).
Our data show that circulations level of PR3 and Jo-1 antibody are elevated in women with POI compared with healthy women. PR3 is the target of anti-neutrophil cytoplasm Abs (ANCA) in granulomatosis with polyangiitis, a form of systemic vasculitis [6, 21]. In our study, among 96 POI patients, 14 patients have anti-PR3 higher levels, which 3 patients had histories of mumps, and the others have no any medical history. Anti-Jo-1 antibody, one of the aminoacyl tRNA synthetases antibodies, is associated with a more abrupt onset of fever, cracked hands, Raynaud's phenomenon, interstitial lung disease, arthritis and PM/DM, which was reported in 20-30% of patients with PM/DM. Antibody to Jo-1 is a kind of anti-nuclear antibody. Anti-Jo-1 antibody levels correlated modestly with muscle and joint disease and more striking associations emerged in a smaller longitudinal subset of patients that link anti-jo-1 antibody levels to muscle, joint, lung, and global disease activity [22–24].there are 10 patients who had positive anti-Jo-1 antibody, 2 patients had histories of tuberculosis and 2 patients had histories of diabetes mellitus. The high level of PR3 and Jo-1 antibody suggest that a role for autoimmunologic process might be present in pathogenesis of POI. But the evaluation of the exact pathways of these antibodies remains to be determined.
Autoimmune diseases, such as autoimmune thyroiditis, diabetes mellitus type1, poparathyroidism, SLE, rheumatoid arthritis and Addison's disease, frequently coexist with POI. 10-40% of women with POI have clinical autoimmune disease, the most common of these is hypothyroidism with an incidence of 27%, followed by diabetes mellitus (2.5%) and Addison's disease (2.5%) [10, 25]. In our study, 4 and 2 patients had histories of thyroid disorder and diabetes mellitus respectively whereas there was no thyroid disorder and diabetes mellitus in healthy-control women. Absence of clinical evidence of other endocrine autoimmune disease, POI patients often exhibit organ-specific auto-antibodies, but there were no significant in antibodies to dsDNA, histone, RNP, Sm, Scl-70, CEN, AC, GBM, PCNA, MPO, TM between the two groups (P > 0.05). Joe Feuerstein reported reversal of premature ovarian failure in a patient with Sjogren syndrome, laboratory tests showed a positive ANA, and a positive SS-A Sjogren antibody, positive anti-CCP and positive anti-Smith [26].
There are no convincing data at this time that patients with systemic autoimmune disorders such as SLE or rheumatoid arthritis (RA) have higher rates of POI than that of general population. But non-organ specific autoantibody has been reported in patients in POI, including antinuclear antibodies and rheumatoid factor [27]. ANA positivity of 42-77% has been reported among chromosomally normal women with POI, POI is not a well-described complication of systemic lupus erythematosis [4] and a positive rheumatoid factor. Interestingly, development of new onset SLE has been associated with slightly earlier age of natural menopause and early age at menopause may be a risk factor for development of rheumatoid arthritis. In our study, there is no significant in ANAs, RF between POI and healthy women groups.
Screening serologic tests, however, are not necessarily recommended because of high false-positive rates. Serologic tests are most useful in confirming or ruling out the diagnosis; for example, SLE is rarely present when ANAs are absent; the absence of RF will not rule out RA, but its presence confirms it. Polymyalgia rheumatica and RA, with an incidence of 1 in 2000 to 3000, are the most common autoimmune disorders. Other autoimmune diseases such as SLE, vasculitis, polymyositis, and dermatomyositis are seen infrequently in general practice. Menopause may affect disease prognosis and treatment.
Mumps oophoritis has been considered to be a cause of POF [28–30], in our study there are 9 patients who had mumps histories. 3 patients have positive PR3 and the others have no any positive antibody.
Our study shows that serum levels of Jo-1 and PR3 antibodies are elevated in women with POI compare with health controls. These results suggest that a role for autoimmunologic process might be present in pathogenesis of POI. Whether or not women with POI are at an increased risk for developing autoimmune diseases is unknown and should be investigated in future trials. The weaknesses of this study are the absence of a direct clinical implication and the necessity elucidating the possible pathways involved.
This study shows that JO-1 and PR3 antibodies were significantly higher in POI women group and may be related with POI, which might help to determine the real prevalence of autoimmune POI. The interplay of autoimmunity with the reproductive endocrine system is complex and incompletely understood yet. We provide new proof on serologic autoimmunologic parameters in women with POI here. The evaluation of the exact pathways of these antibodies to POI remains to be determined.
Primary ovarian insufficiency
Premature ovarian failure
Systemic lupus erythematosus
Thyroid microsomal
Adrenocortical antibodies
Antinuclear antibodies
Rheumatoid factor
Zona pellucida
- ds-DNA:
Double-stranded DNA
- ssDNA:
Single-stranded DNA
Nuclear ribonucleoprotein
- Sm:
Smith antigen
Sjogren's syndrome A
- SSB/La:
Sjogren's syndrome B
Proteinase 3
Anti-neutrophil cytoplasmic antibody
- Scl-70:
Scleroderma-associated antigen
Proliferating cell nuclear antigen
Glomerular basement membrane
Mixed connective tissue disease.
We would like to thank all the patients and physicians for participating in this study. This study is supported by grants from the Doctoral Fund of Ministry of Education of China (20090001110090).
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.


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Zoe and Norman's obvious compatibility - crossover jobs, middle-class backgrounds, wealth and celebrity - has left the traditional granny blather about "opposites attract" out in the cold. The thrill value of whirlwind romances, such as Drew Barrymore's six-week marriage to a Welsh barman ("the worst mistake of my life") and Pamela Anderson's quickie beach ceremony with Tommy Lee weeks after he introduced himself by licking her face, are out of step at a time when even our most iconic pop stars are choosing reliable, clean-living partners (Louise's Jamie Rednapp, Posh's David Beckham, Kate Winslet's Jim Threapleton) and showing their confidence by racing down the aisles.
Jade Jagger summed up the new mood of modern romance perhaps more poignantly than she realised when she revealed why her new boyfriend Dan Macmillan (great-grandson of Tory premier Harold) is "the one". "Finally I've got someone who isn't in awe of me and my background," she said. While it's rather discomforting that she has found happiness the Jane Austen way - copping off with someone equally loaded - in many ways it makes sense. Jagger tried for years to make her relationship with the struggling artist Piers Jackson work, but her cultural commonality with Macmillan - she is a model and jewellery maker, he an ex-model and photographer - means they connect in a way Jagger's attempts at playing earth mother with Jackson never could.
Similarly, Princess Caroline of Monaco, after years of doomed relationships with wideboys and womanisers, has found peace with someone who can truly empathise with her - another royal, Prince Ernst of Hanover. And Nicolas Cage (of the Coppola dynasty), after years of playing the field, has met his match with Patricia Arquette (of the acting family).
"For celebs, the pressures of being a cardboard cut-out of other people's fantasies, envies and fears is difficult to understand from the outside," says Professor Petruska Clarkson, who has carried out studies on the psychology of fame, "so it's natural that celebrities seek each other out."
Of course, were fame enough to guarantee happiness, Hollywood wouldn't be the delightful den of iniquity it is. The reality is, that celebrity or otherwise, the relationship battlefield remains strewn with the blood of an army of dead romances. "It makes you wonder why Western culture scoffs at the arranged marriages of the East," says Professor Clarkson. "Look at the mess we're in."
Samantha Cohen, 28, for one, initially welcomed the differences between her background and her boyfriend's. She had met Richard, 30, at university. "We were totally different," she says, "which we both thought was great. I was from a working-class family in Liverpool, had gone to the local comp and did a part-time job to help me pay my college fees. He was from an incredibly wealthy, landowning family. We were so unlike each other it was incredibly exciting.
"After university, I got a job with a law firm in London. Richard had no need to work and wasn't very supportive about me putting in long hours. I realised that he had a completely different outlook on life. He was there for the laugh, but to me it was important to earn money and make my way. We lurched on for another couple of years, but with him using my place as a dosshouse I'd had enough. He didn't respect my motivations and background, and we split last year."
According to Sarah Litvinoff, author of The Relate Guide to Better Relationships, Samantha's story is typical of the way relationships can crack when the balance of power shifts. No wonder Lottery winners are always so miserable - they've realised too late that the brand new faux-Tudor mansion and fleet of sports cars don't go down well with mates who still drive Ford Fiestas. "The way the dynamic is altered in a relationship is an extreme experience - it's like being in a war or coping with the death of a spouse," says Litvinoff. "Your very foundations are shaken."
This is how it feels to be confronted with sudden fame - and the relationship fall-out is notorious. Celebs ditching their partners on making it big has long been an industry joke. Ralph Fiennes famously divorced the then- unknown Alex Kingston after 12 years together after being nominated for an Oscar for Schindler's List and embarking on an affair with Franscesca Annis. Kingston blamed their sudden inequality for the split. More recently, Ralph's brother Joseph, whose ex-girlfriend Sara - also an actor - supported him for years while he struggled with a codpiece at the RSC, has now been shunted in favour of the more successful Catherine McCormack. Paul Hogan's wife of 22 years got similar treatment when he left her for his Crocodile Dundee co-star Linda Kozlowski, but The X-Files' Gillian Anderson needed no such excuse, apparently spelling it out for the Sun last year. "I've outgrown my husband," she said bluntly. "He bores me."
While it's comforting to think celebs are more prone to such insouciance than the rest of us, the reality is different. A housewife might study for a degree and start to review her life, Educating Rita-like, with newly critical eyes. Or a bluecollar worker, married at 22, might find years later, as an executive, that he has nothing in common with his wife.
The way to protect the dynamic of their relationship, according to Litvinoff, is to retain a currency to barter with. Sophie Rhys-Jones, for example, while not a member of the aristocracy, has spent long enough hanging out with the Queen Mum to be under no illusions about Royal life. To Edward, this is a highly prized commodity, as is his wife's career and independence. Similarly Wayne, Melinda Messenger's much-teased house-husband, has held his relationship together because, as Messenger's career has expanded, he provides a link to her past, which she still wants.
Baz Bamingboye, showbiz editor at the Daily Mail, who has spent years analysing relationships concurs. "The days of a Marilyn Monroe and Arthur Miller marrying are over," he says. "People are choosing from their own spheres. Sharon Stone's husband Phil Bronstein, a newspaper editor, isn't overly rich or famous, but they have similar backgrounds and philosophies. He's not intimidated by Sharon, so they're equal and have an understanding. I guess that's why it works."
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John's account of the origin of the invaders is followed by a vivid description of them (just as for the locusts). The description only heightens our sense of terror as we move from the fifth trumpet to the sixth. The horses John sees are not simply a means of transportation for human soldiers. Horses and riders are described together as one complex and terrible creature, like the centaur of Greek mythology. They are not human but demonic, and their job is to carry out the commission of the four angels from the Euphrates to kill a third of mankind (v. 15; compare v. 18).
While the locusts in the preceding vision had "tails and stings like scorpions" (v. 10), these horses had tails like snakes (v. 19) with similar power to injure (again, see Jesus' promise of authority over both "snakes and scorpions" in Lk 10:19). Even worse, out of their moutes came fire, smoke and sulfur, viewed as three distinct plagues bringing death to one-third of the human race (vv. 17-18). If the first four trumpets brought "fire" on the earth (8:7, 8, 10), and the fifth, "smoke from the Abyss" (9:2), the sixth adds sulfur to the conflagration. These three plagues of fire, smoke and sulfur (v. 18) will become basic elements in John's subsequent visions of eternal punishment (compare 14:10-11; 18:9, 18; 19:3, 20; 20:10; 21:8). "Sulfur" in the King James Version becomes "brimstone," creating the expression "fire and brimstone" for preaching based on the fear of hell.
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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
currently facing two aggravated assault charges and two misdemeanor charges. has previous record of assault and battery, intimidation of a witness, violation of probation and violation of a restraining order. whats the minimum for the felony charges?
Chapter 265, Section 13A of the Massachusetts General Laws creates the crimes of assault and battery and so-called "aggravated" assault and battery, which is assault and battery that is committed with three possible aggravating circumstances: A&B which causes serious bodily injury, A&B against a pregnant woman, or A&B against a person who has an abuse prevention order against the defendant.
There are no minimum sentences for any of these crimes. Simple assault and battery is a misdemeanor punishable by up to 2 1/2 years in the house of correction; the aggravated offenses are punishable by up to five years in state prison (if you are indicted and prosecuted in superior court) or up to 2 1/2 years in the house of correction (if the case is prosecuted in district court). The essential difference between regular A&B and an aggravated form of A&B is that aggravated A&B is a felony, while simple A&B is a misdemeanor. A felony conviction can have substantial effect on collateral matters, including your citizenship (if you are not a citizen), your ability to get or maintain a job, or your housing status.
If you have a serious prior record including convictions for violent offenses, the Commonwealth may indict you and prosecute you in the Superior Court, where you could be sentenced to time in state prison.
Speak to a criminal defense attorney immediately about your options.
There is no minimum mandatory sentence for aggravated A&B. On a plea, given your record, you are probably looking at a conviction, as opposed to a CWOF or some other non-conviction disposition, but you may not have any prison time imposed and could get probation. The actual sentence imposed depends on a variety of factors such as the facts of the specific case, prior record, injury to the victim, substance abuse, and mental health issues, just to name a few.
Best of luck,
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The Horse Forum (http://www.horseforum.com/forumindex.php)
- Farm Forum (/farm-forum/)
- - Boarding NJ (http://www.horseforum.com/farm-forum/boarding-nj-75520/)
Boarding NJ
I'm am looking into adopting a horse but I need to find an affordable (and adequate) facility close to the Budd Lake, NJ area 07828 area code.
Does anyone know of any places (under $300/month)
Its a tough price but I couldn't find anything online so far. :(
That may be a tough one...boarding is so darn expensive around here!
How close to Budd Lake? I found this ad on Craigslist...but it's up by Newton.
***Reliable Care for your Horse(s)***
Good luck !
Thank you for the info! I'll check it out!
Hi Ecco...
I was trolling through Craigs List again this morning and found one closer to you, in Roxbury, which sounds pretty nice...
2 stalls avail at private farm
thank you that place looks like an really good deal :)
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You can cheer up along with sleepy Jean by listening to "Daydream Believer."
If you find that passage as much of a downer as I did, well, cheer up, Charlie.
"When the cards started to come, I had to cheer up," she says.
"Well, cheer up; your brother is just behind," and as he spoke Lancy joined him.
And then," said Margaret, "Hester will be the first to cheer up and comfort us.
Now, dont start talking about your wife, said Dr. OGrady, just as youre beginning to cheer up.
cheer up, Harry, there is a canoe approaching; it will bring us help.
The incident, however, served to cheer up the Major, though he continued to deplore the loss of his beautiful dog.
The mailman, to whom he expressed these sentiments, told him to cheer up.
cheer up, mother; things are no worse than they were last night.
c.1200, "the face," especially as expressing emotion, from Anglo-French chere "the face," Old French chiere "face, countenance, look, expression," from Late Latin cara "face" (source of Spanish cara), possibly from Greek kara "head," from PIE root *ker- "head" (see horn (n.)). From mid-13c. as "frame of mind, state of feeling, spirit; mood, humor."
By late 14c. the meaning had extended metaphorically to "mood, mental condition," as reflected in the face. This could be in a good or bad sense ("The feend ... beguiled her with treacherye, and brought her into a dreerye cheere," "Merline," c.1500), but a positive sense (probably short for good cheer) has predominated since c.1400. Meaning "shout of encouragement" first recorded 1720, perhaps nautical slang (cf. earlier verbal sense, "to encourage by words or deeds," early 15c.). The antique English greeting what cheer (mid-15c.) was picked up by Algonquian Indians of southern New England from the Puritans and spread in Indian languages as far as Canada.
late 14c., "to cheer up, humor, console;" c.1400 as "entertain with food or drink," from cheer (n.). Related: Cheered; cheering. Sense of "to encourage by words or deeds" is early 15c. Which had focused to "salute with shouts of applause" by late 18c. Cheer up (intransitive) first attested 1670s.
Related Terms


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Wego.com.sg recently found 14 hotels in Glenrothes, United Kingdom. Book last minute hotel or find great hotel deals such as Holiday Inn Express GLENROTHES for S$259 per night. Save more on cheap hotels with rates from as low as S$131 per night.
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Bavarian Cream (Bavarois A La Crame)
|Egg yolks
|Caster sugar
|2 Tablespoon
|Vanilla pod/3 drops of vanilla essence
|3⁄4 Pint
|1⁄2 Ounce
|5 Tablespoon
|Double cream
|1⁄4 Pint
1) In a bowl, whip the cream partially.
2) In a saucepan, add yolks and sugar and cream.
3) In a bowl, add milk and vanilla pod and allow to infuse. (If using vanilla essence, add in to the yolk mixture).
4) When well flavored, discard the pod and add the milk to the yolks and blend.
5) Place saucepan on heat and keep stirring till the mix coats the spoon.
6) Strain into a bowl and cool.
7) In a pan, add water and gelatin and soak for 4-5 minutes.
8) When the custard is completely cold, then place the gelatin over heat and allow to dissolve.
9) Add the hot gelatin into the custard and mix well.
10) In a serving plate, turn out the custard.
11) Stand the plate in a bowl of cold water with ice.
12) Stir till the mix begins to thicken, then add 2 tablespoons of the partially- whipped cream.
13) Transfer custard into a lightly-greased mould and leave to set.
14) Turn out carefully and spread the rest of the cream.
15) Decorate with additional cream before serving.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1102 Calories from Fat 762
% Daily Value*
Total Fat 85 g130.1%
Saturated Fat 11 g55.1%
Trans Fat 0 g
Cholesterol 591.3 mg197.1%
Sodium 193.4 mg8.1%
Total Carbohydrates 55 g18.4%
Dietary Fiber 2 g7.9%
Sugars 49.8 g
Protein 33 g65.3%
Vitamin A 20.3% Vitamin C
Calcium 49.9% Iron 8.3%
*Based on a 2000 Calorie diet


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Stayed at Biloxi Hard Rock first two days of Feb/13. As usual the rooms were outstanding, the view beautiful and the food hard to beat. We come down from the icy cold of the north (northern Wis) to stay the month of Feb in the area. We are treated to free rooms, food and music venues. The bathrooms that we have had during our many stays are better than I have seen in some homes. It was busy because of Super Bowl weekend but we got great service. The pool is outside so we didn't get to use it. We ate at the 24/7 grill, food was generous and free but they don't serve breakfast 24/7. Breakfast ends at 11 am, which is odd for a casino and needs to be expanded. You are less than a hours drive from Mobile AL and New Orleans La so it is a great central location. The casino is average, they have a poker room and other table games.
- Official Description (provided by the hotel):
- Hard Rock Hotel & Casino Biloxi is a striking 12-story purple and white hotel tower announced by the world's largest Hard Rock Guitar sign. With its modern design, Hard Rock Biloxi boast high cellings, an open casino floor, a sleek nightclub and boutique rooms with walk-in showers. Located in the heart of the Mississippi Gulf Coast, guest can easily access the beach as well as take in spectacular views of the Gulf of Mexico. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Agoda and Booking.com so you can book your Hard Rock Hotel & Casino Biloxi reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Hard Rock Hotel And Casino Biloxi
- Hard Rock Hotel Biloxi
- Hard Rock Biloxi


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IBM Expands Federal Cloud Ecosystem, Spurs First Responders
Big Blue welcomes five new partners to its federal cloud ecosystem and taps developers to build cloud apps for first responders.IBM announced that five new cloud partners have joined its growing ecosystem serving the U.S. federal government. In addition, IBM is working with developers to create new cloud apps for first responders. Together with IBM, these resellers and distributors will focus on delivering new hybrid cloud solutions across federal agencies. Arrow, Avnet Government Solutions, Ingram Micro, Tech Data Corporation and ViON will combine and bundle their solutions with IBM Cloud. Yet, despite all the attention that the federal government has placed on cloud, IDC estimates that only about 6 percent of federal applications run in the cloud. At the same time, the Obama Administration's proposed fiscal 2016 budget estimates that about $7.3 billion will be spent on cloud computing and not simply for cost savings, but also to change how services are delivered. "Federal agencies are really beginning to view cloud as transformational, but first they need a reliable partner to help them get started," said Anne Altman, general manager of IBM U.S. Federal and Government Industries, in a statement. "With our partners, we have a strong understanding of the IT investments agencies have made, and how to help them with their migrations to cloud in a secure and strategic way."
The new partners include Arrow, which helps partners integrate IBM's Cloud Infrastructure as a Service (IaaS) into their products and services, and assists in building cloud solutions from the IaaS layer up.
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This article details how to add an additional or new user to an encrypted disk without using the passphrase for the existing user.
In a PGP Universal Server managed environment, you can add a new user to an encrypted disk by using the WDRT for the existing user for authentication at the PGP BootGuard screen and then adding a new user to the disk using the command line interface. This allows you to add a new user to the disk without needing to know the passphrase of the existing user.
Whole disk recovery tokens are associated with encrypted devices, not single computers or single users. If multiple users have accounts on the same device, they share the same whole disk recovery token. Whatever you do with the token affects all users sharing that device.
To add a new user to an encrypted disk
- Log into the PGP Universal Server admin interface.
- Click Consumers > Users and then browse for and select the existing user. The user information is displayed.
- Expand Whole Disk Encryption and click the icon in the WDRT column. The WDRT is displayed.
- Record the WDRT for the system and use the WDRT to authenticate at the PGP BootGuard on the client computer.
- On the client computer, open a Windows command prompt.
- Browse to the PGP Desktop directory: C:\Program Files\PGP Corporation\PGP Desktop (32-bit) or C:\Program Files (x86)\PGP Corporation\PGP Desktop (64-bit)
- Type pgpwde --add-user -u <username> --passphrase <passphrase> --rt <wdrt> and then press Enter.
The new user is added using the WDRT for authentication.
Legacy ID
Terms of use for this information are found in Legal Notices.
Terms of use for this information are found in Legal Notices.


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Welcome to Baystate Ford's website! We are a proud used car dealer, located near Milford, Massachusetts. We service Milford, Massachusetts for all individuals looking to buy or service a used Mercedes-Benz.
Baystate Ford carries a wide selection of used Mercedes-Benz near Milford, Massachusetts. Using our website you can view our used Mercedes-Benz cars.
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Baystate Ford is your top choice for a used dealer and is located in South Easton, MA and is just a short drive from Milford, MA.


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Three-Pepper Steak
|Beef porterhouse/T-bone steaks cut 1 1/2 inches thick
|2 Pound
|Whole black peppercorns
|1 Teaspoon
|White peppercorns
|1 Teaspoon
|Szechuan peppercorns
|1 Teaspoon
|Ground allspice
|1⁄8 Teaspoon
Trim fat from steaks.
Coarsely crush peppercorns on a cloth with a rolling pin or with a mortar and pestle.
Combine crushed peppercorns and allspice.
Sprinkle both sides of steak with the pepper mixture; press into surface, place steaks on the cooking grill.
Grill 10 to 12 minutes for rare, 12 to 15 minutes for medium, or 15 to 19 minutes for well-done; turn once halfway through grilling time.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 2071 Calories from Fat 1217
% Daily Value*
Total Fat 135 g207.6%
Saturated Fat 54.6 g272.8%
Trans Fat 0 g
Cholesterol 508.1 mg169.4%
Sodium 490.7 mg20.4%
Total Carbohydrates 12 g3.9%
Dietary Fiber 1.4 g5.8%
Sugars 0 g
Protein 189 g378.1%
Vitamin A 0.1% Vitamin C 2.2%
Calcium 7.2% Iron 105.5%
*Based on a 2000 Calorie diet


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A large numbers of metrics have been proposed for measuring properties of object-oriented software such as size, inheritance, cohesion and coupling. The coupling metrics presented in this paper exploring the difference between inheritance and interface programming. This paper presents a measurement to measure coupling between object (CBO), number of… (More)
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Massereene murder trial decision delayed
- 21 October 2010
- From the section Northern Ireland
A judge has delayed a decision on whether two men will stand trial for the Real IRA murders of two soldiers at Massereene barracks last year.
Colin Francis Duffy, 42, from Forest Glebe in Lurgan and Brian Patrick Shivers, 45, from Sperrin Mews in Magherafelt are charged with murder.
They also face several charges of attempted murder.
The case was adjourned after prosecution lawyers asked for more time to examine a fresh defence submission.
Sappers Mark Quinsey and Patrick Azimkhar were shot dead by gunmen on 7 March last year, hours before they were due to be deployed to Afghanistan.
A number of other people were wounded, including a man delivering pizza to the soldiers.
Defence lawyers raised a Court of Appeal case where a conviction was quashed on the basis that DNA evidence was insufficient to convict a man.
The evidence in this case, which defence lawyers claimed was similar to the one being made against their clients, involved an attempt to burn a car, Coleraine Magistrates Court was told.
The men's lawyers argued the evidence in the Court of Appeal case was stronger than that against their clients.
District Judge George Connor said that this was a significant development and the prosecution should be allowed to take their time to analyse the case.
The court is to reconvene via videolink on 26 October to set a date for the conclusion of the preliminary enquiry into whether the two men should stand trial.


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STEM Teacher Information SessionApril 15, 4:30pm - 6:00pm
Mānoa Campus, Bilger Hall 150
Join us at our second annual STEM Teacher Information Session!
Keynote Talk: "Green Shoots - Your Future in STEM" by Linda Furuto, Associate Professor of Mathematics Education.
Welcome Address & Presentations by: Krystyna Aune, Interim VCAA; State of Hawaii Department of Education; College of Education
Ticket Information
RSVP required: www.hawaii.edu/natsci/rsvp/greenshoots.html
Event Sponsor
College of Natural Sciences & College of Education Office of Student Academic Services , Mānoa Campus
More Information
Lynne Higa, (808) 956-4744, email@example.com, STEM Teacher Information Session (PDF)


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Each April 2, Autism Speaks celebrates Light It Up Blue along with the international autism community, in commemoration of the United Nations-sanctioned World Autism Awareness Day. Light It Up Blue is a unique global initiative that kicks-off Autism Awareness Month and helps raise awareness about autism.
Turn your profile picture blue to support autism awareness! At Autism Speaks (www.autismspeaks.org), our goal is to change the future for all wh... more →


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Dog Boarding in University Area, Anchorage
Find a loving dog sitter to watch your dog overnight at your sitter's home.
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Experience exceptional service and a personalized match
From start to finish, we'll handle all the details for you.Learn About Premier
Rover also offers dog boarding in these other Anchorage neighborhoods:
|Airport Heights
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As dog lovers, we understand how difficult it can be to leave your dog when you have to head out of town. Luckily, you can find the perfect University Area dog sitter in seconds on Rover.com. If you're looking for dog boarding while you're away, whether it's for one night or a whole month, you can find a dog sitter in University Area, Anchorage, AK who meets your and your dog's needs. We manually review and approve every profile on our site, and we offer tools to help you make the right decision for your dog, including background checks and community reviews. We also offer educational opportunities and extra safety tools, such as the Protection Package. And we always recommend an in-person Meet & Greet so you can see that your sitter is the perfect fit for your dog. Rover is proud to be the nation's largest network of dog lovers for hire, and that includes offering pet boarding in University Area.
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Book a Stay, Donate to a Cause
Sit a Dog, Save a Life lets you raise money for local dogs-in-need by doing something you do already: asking your neighbors to watch your dog instead of leaving them in a kennel. Many Rover sitters in University Area, Anchorage donate a percentage of their earnings to nonprofits through Sit a Dog, Save a Life. When you book with a sitter who has the Rover Donation Badge on their profile, you're helping dogs in need, right here in Anchorage.
We're proud to support over 200 organizations across the nation, including:


text:
Politicians, senior journalists and analysts have called for an independent and transparent probe into allegations against Geo News.
On the complaint of the Inter-Services Intelligence (ISI), the Defence Ministry on Tuesday directed the Pakistan Electronic Media Regulatory Authority (Pemra) to take action against the Geo TV network for levelling allegations against the ISI.
The complaint also seeks trial of the channel's editorial team and management for 'maligning' ISI and its DG.
Senior Journalists
Iftikhar Ahmad
Ayaz Latif Palijo
Zahid Khan
Hasil Bizenjo
Athar Minallah
Allama Tahir Ashrafi
Print Story


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'Modern Family' star Jesse Tyler Ferguson to marry in July
"Modern Family" star Jesse Tyler Ferguson is rushing to put the finishing touches to his wedding plans as he prepares to marry his fiance Justin Mikita in July.
RELATED: Stars React to the Prop 8 Supreme Court Hearing
The openly gay actor proposed to the lawyer last year, and Ferguson says their trip down the aisle is now just weeks away. During an appearance on "The View" on Friday, he said, "We're getting married next month. Very exciting. ... We have 250 people coming!"
RELATED: 2012 Hottest Emmy Couples
The nuptials will take place in New York, where gay marriage was legalized in 2011, and Ferguson reveals they briefly considered changing the location after Proposition 8, California's ban on same-sex marriage, was ruled unconstitutional on Wednesday.
RELATED: Anderson Cooper: 'I'm Gay'
He explained, "We planned on getting married in New York 'cause that's where it was legal; it wasn't legal in California up until yesterday. Weddings are expensive y'all, and we wanted to give that money to a state that accepted us as an equal. ... We're too far down the planning path to change."
In lieu of wedding gifts, the pair is asking for donations to its marriage equality charity Tie The Knot to help other same-sex couples win the same rights in other states.


text:
Roma striker Mattia Destro is not for sale his agent has insisted, despite rumours to the contrary.
Reports in the Italian Press over the weekend claimed that Wolfsburg and Tottenham could potentially be interested in signing the youngster.
However, the goalscorer's representative has claimed that the 23-year-old will stay in the capital.
"Destro is not for sale," Renzo Contratto told Corriere Giallorossi. "I will keep repeating that.
"Destro does not want to leave Roma, and they do not want to let him go.
"Mattia can't wait to start the season and play in the Champions League.
"It's obvious that he's a great young striker and could be of interest to many clubs, but he won't be leaving Roma."
Keep up to date with the latest news and action from Spain's Primera Division with Football Espana - from the team behind Football Italia.


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- 06-28-2014, 01:07 PM Thread Author #1
Problem with bluetooth Galaxy S5 abd MB C300
I picked up a new GalaxyS5 and it synched perfectly. Unfortunately after 2-3 weeks the phone had to be replaced because of issues with it I was sent a replacement S5 and that seemed to pair well with the MB Bluetooth, but only a small number of the contacts were transferred to the car. I spent over 1 1/2 hr with T-Mobile and then another 1 hr with Samsung and they couldn't help. Anyone have any suggestions?
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Re: Problem with bluetooth Galaxy S5 abd MB C300
I am honestly not sure. Have you posted this on our sister site, Connectedly?
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Hotels in Solivella, Spain
Search & Compare Solivella Hotels
Get Secret Prices on select hotels
These prices aren't available to everyone.
Trending now in Solivella
Hotels in Solivella
- Most bookedHotel Balneari de Rocallaura
15 people looked at this hotel in the last hour
Most recent review
"very quiet, quite a large hotel, not many guests, said more busy in off season when people come for natural spa facility. need car to explore area which is beautiful."
A Traveller, Jun 2015, GB
Hotels within 10 miles of Solivella
11 people looked at this hotel in the last hour
11 people looked at this hotel in the last hour
- Hotel Regina Spa by Singular'sNo Guest Reviews yet
6 people looked at this hotel in the last hour
Hotels within 15 miles of Solivella
38 people looked at this hotel in the last hour
Most recent review
"As this is one of two hotels in Valls the choice was limited, however we were pleasantly surprised to find a three star hotel with the available services and a decent on site restaurant. All the staff was very pleasant, especially the restaurant waiter who was absolutely brilliant, and the place ..."
A Traveller, Nov 2016, GB
24 people looked at this hotel in the last hour
Most recent review
"overnight stop on my way home.my satnav couldnt find it and as it was dark i felt a bit lost.however nxt am as i left i realised it should have been easy. i liked the hotel very much and think it could be a good base for sightseeing.yes if i need to stay again in the area hotel felix will be my c..."
A Traveller, Mar 2016, GB
Hotels within 20 miles of Solivella
18 people looked at this hotel in the last hour
Most recent review
"Very high quality boutique experience, this villa away from the hussle and bussle 12 km from Tarragonna was built in 1922 and in the middle of millions of olivetrees, very 'homy' feeling super friendly staff, indoor restaurant with high quality food. Spa and a large outdoor pool available! We ..."
P, Sep 2016, US
14 people looked at this hotel in the last hour
Most recent review
"Stayed with our 3 chn in Aug for a week. Rooms were spotless, cleaned every day. Air con was great but didn't need it all the time. Even though the hotel itself doesn't have a pool we had the use of the local Olympic sized swimming pool which was lovely and which we had almost to ourselves. Carme..."
A Traveller, Aug 2015, IE
- Rural JordàNo Guest Reviews yet
7 people looked at this hotel in the last hour
- Mas BoronatNo Guest Reviews yet
6 people looked at this hotel in the last hour
Best hotels in Solivella
You can compare all of our Solivella hotel rooms including the major Solivella hotel chains using our genuine Hotels.com guest reviews as well as TripAdvisor Solivella hotel reviews to help find the perfect hotel room when booking your accommodation in Solivella. We also feature Expedia Solivella hotels and reviews.
When you book your Solivella stay with Hotels.com you may also earn free nights on participating hotels by joining the Hotels.com Welcome Rewards program. It's free to join and only takes 2 minutes to sign up and when you stay 10 nights you receive 1 night free*. So even a short weekend break in Solivella can get you on your way to a free night.
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To make the most of our service, download our mobile & tablet apps and sign up to our newsletter or follow us on Facebook, Google+ or Twitter to receive the latest deals and Hotels.com Solivella discount codes.


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Sausage Bacon and Cheese Kebabs
|Chipolata sausages
|8 Ounce (225 Gram)
|Bacon rashers
|24 , each rolled up and secured, with a cocktail stick
|8 Ounce (225 Gram, Of Different Varieties, If Desired To Add Color)
1. Cut the cheese into small cubes.
2. Grill the sausages under a broiler, on a barbecue or in a skillet.
3. Cut each into 3 pieces and keep hot.
4. Grill the rolled bacon until well cooked but not too crispy, and keep hot.
5. Thread a piece of cheese, sausage, another piece of cheese, a roll of bacon, and then finally another piece of cheese on each cocktail stick.
6. Arrange the kabobs on a platter.
7. Serve immediately while warm as a cocktail appetizer
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 116 Calories from Fat 82
% Daily Value*
Total Fat 9 g14.2%
Saturated Fat 4.3 g21.3%
Trans Fat 0 g
Cholesterol 16.5 mg5.5%
Sodium 141.7 mg5.9%
Total Carbohydrates 0.5 g0.17%
Dietary Fiber 0 g
Sugars 0.3 g
Protein 8 g15.3%
Vitamin A 1.9% Vitamin C 0.16%
Calcium 6.9% Iron 1.1%
*Based on a 2000 Calorie diet


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- Put your Boston Red Sox pride on display. Adorned with special Boston Red Sox graphics to highlight the legendary career of David Ortiz this is the perfect addition to your wardrobe.
- 100% Cotton
- Short sleeve
- Machine wash, tumble dry low
- Officially licensed
- Imported
Customer Reviews
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- 1 the top layer of the earth in which plants, trees, etc. grow poor/dry/acid/sandy/fertile, etc. soil the study of rocks and soils soil erosion Synonymssoilmud dust clay land earth dirt groundThese are all words for the top layer of the earth in which plants grow.soil the top layer of the earth in which plants grow:Plant the seedlings in damp soil.mud wet soil that is soft and sticky:The car wheels got stuck in the mud.dust a fine powder that consists of very small pieces of rock, earth, etc:A cloud of dust rose as the truck set off.clay a type of heavy sticky soil that becomes hard when it is baked and is used to make things such as pots and bricks:The tiles are made of clay.land an area of ground, especially of a particular type:an area of rich, fertile landearth the substance that plants grow in. Earth is often used about the soil found in gardens or used for gardening:She put some earth into the pot.dirt (especially North American English) soil, especially loose soil:Pack the dirt firmly around the plants.ground an area of soil:The car got stuck in the muddy ground. They drove across miles of rough, stony ground. Ground is not used for loose soil:a handful of dry groundPatterns good/rich soil/land/earth fertile/infertile soil/land/ground to dig the soil/mud/clay/land/earth/ground to cultivate the soil/land/ground See related entries: Growing crops
- 2(literary) a country; an area of land It was the first time I had set foot on African soil. Word Originnoun late Middle English: from Anglo-Norman French, perhaps representing Latin solium
nounjump to other results
BrE BrE//sɔɪl//; NAmE NAmE//sɔɪl//[uncountable, countable] Growing crops
Check pronunciation: soil


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AC Milan vice-president Adriano Galliani has revealed his club's interest in Chelsea strikers Nicolas Anelka and Didier Drogba.
The Italian champions are looking to reinforce their attacking line in the winter transfer market with Antonio Cassano ruled out indefinitely after undergoing a heart procedure earlier this month.
Anelka and Drogba are both in the final year of their contracts with Chelsea and have been linked with a move to the San Siro outfit in January.
"If Cassano returns to play in a short space of time then we will not bring a reinforcement," Galliani said as reported in Gazzetta dello Sport. "We will evaluate what to do further on.
"Perhaps only one (striker) will arrive in spring.
"Anelka? He continues to score, we shall see. He is an important player but I was in love with Drogba when he played at Marseille."
- More about:
- AC Milan
- David Jones (Footballer)
- Didier Drogba
- Italy


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Coffee Ice Cream Eclairs
|Ice cream
|1 Quart (Vanilla Or Coffee)
|Light corn syrup
|1 Cup (16 tbs)
|1 1⁄2 Cup (24 tbs)
|Instant coffee powder
|1 Tablespoon
|3 Tablespoon
|2 Tablespoon
|1 Teaspoon
|Chopped pecans
|1⁄2 Cup (8 tbs), chopped
Prepare Basic Eclair dough.
Using about 1/4 cup dough for each eclair, drop from spoon onto greased baking sheet 2 inches apart, leaving 6 inches between rows.
Shape each mound into a 4x1-inch rectangle, rounding sides and piling dough on top.
Bake and cool as directed.
Fill bottom halves of eclairs with vanilla or coffee ice cream; replace tops.
Keep in freezer till serving time.
Meanwhile, to make sauce, measure corn syrup into saucepan.
Combine water and coffee powder; blend in cornstarch.
Stir into syrup in pan.
Cook and stir till thickened and bubbly.
Remove from heat; add butter and vanilla.
Stir till butter melts; stir in pecans.
Recipe Summary
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Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 4047 Calories from Fat 1791
% Daily Value*
Total Fat 203 g311.6%
Saturated Fat 103.9 g519.3%
Trans Fat 0 g
Cholesterol 592.9 mg197.6%
Sodium 770.2 mg32.1%
Total Carbohydrates 547 g182.3%
Dietary Fiber 5.9 g23.5%
Sugars 293.6 g
Protein 41 g82.4%
Vitamin A 111.8% Vitamin C 15.3%
Calcium 132.2% Iron 12.9%
*Based on a 2000 Calorie diet