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|Apple ・ Security ・ Cybercrime ・ Microsoft ・ Google ・ Data Centers ・ Android ・ Telecom ・ Malware
EARLIERCarmakers Hitch Ride with Tech on Futuristic Road
THIS STORYIBM Predicts 5 Life-Changing Innovations for the Next 5 Years
LATERBiggest Self-Driving Car News from CES 2017
By Jef Cozza. Updated January 6, 2017 9:39AM
New diagnostics for brain disorders based on speech pattern analysis, imaging devices that will let us see the whole electromagnetic spectrum and entire medical labs each built onto a single computer chip are just a few of the advances we can expect to see in the next five years, according to IBM.
Yesterday, Big Blue released its "IBM 5 in 5," an annual list of innovations that the company predicted will have major impacts on the way we live over the next five years.
"With advances in artificial intelligence and nanotechnology, we aim to invent a new generation of scientific instruments that will make the complex invisible systems in our world today visible over the next five years," said Dario Gil, vice president of science and solutions at IBM Research, in a statement.
New Windows into Mental Health
One of the developments identified in the list is the use of deep learning machine intelligence to help clinicians predict and monitor brain and mental health disorders such as psychosis, schizophrenia, mania and depression. The company said its scientists are currently using transcripts and audio recordings of psychiatric interviews to find speech patterns that can indicate such disorders.
In addition to giving health professionals unprecedented access to the human mind, artificial intelligence will also play a role in providing a larger window into the world around us.
Over the next five years, new devices using hyperimaging technology and artificial intelligence will help us see broadly beyond the domain of visible light by combining multiple bands of the electromagnetic spectrum to reveal valuable insights or potential dangers that would otherwise be unknown or hidden from view, the company said. And such technology will be broadly and cheaply available.
"For example, using millimeter wave imaging, a camera and other sensors, hyperimaging technology could help a car see through fog or rain, detect hazardous and hard-to-see road conditions such as black ice, or tell us if there is some object up ahead and its distance and size," the company said.
Collecting More Data, and Analyzing It Better
As new technologies make a broad range of new data available, machine learning will also help organize and analyze this new information. IBM said that within five years, we will be able to use machine learning algorithms and software to organize information about the physical world to make sense of the vast and complex data gathered by billions of devices.
"By aggregating, organizing and analyzing data on climate, soil conditions, water levels and their relationship to irrigation practices, for example, a new generation of farmers will have insights that help them determine the right crop choices, where to plant them and how to produce optimal yields while conserving precious water supplies," according to IBM.
Apart from artificial intelligence, nanotechnology will also be a major source of innovation, particularly in the health industry. IBM said that nanotechnology will enable the development of lab-on-a-chip devices that will allow people to quickly and regularly measure the presence of biomarkers found in small amounts of bodily fluids, and then stream that information into the cloud from the convenience of their homes.
Finally, advances in smart sensor technologies combined with silicon photonics will make it possible for devices to make highly complex computations, literally at the speed of light. Such technologies will allow scientists to create more complicated environmental models and better track sources of environmental contamination, IBM noted.
Michael Will:
Posted: 2017-02-06 @ 6:05am PT
I think it's a mistake to conflate massive data sifting and AI. Information, even after it is massaged intensively, is not knowledge. "Insight" is not discovery, in fact it may only feed human bias. A universe of monkeys typing away may someday write "Hamlet", but...
Raymond Rhyno:
Posted: 2017-01-27 @ 5:13am PT
Remember what Frank Solitis said was going to happen in his 2014 tour. He said they were looking at an individuals DNA and prescription drugs would be designed for that individual. This is going to mean big changes for this in the Health insurance as well because currently each plan only covers a defined drug.
Posted: 2017-01-08 @ 5:46pm PT
More pictures would have made this article more savoring.
Biggest Self-Driving Car News from CES 2017
By Gedalyah Reback. Updated January 09, 2017.
After CES 2016's blockbuster announcement that Lyft had raised $1 billion to develop self-driving cars, the year turned out to be awash with news from the industry. Exceeding expectations, observers knew to expect a lot of news on the sector in 2017. That came, with a whole lot of riff-raff mixed in. Despite the avalanche of talks and announcements, these are five major developments (or sets of developments) that set the tone for which companies will advance quickly with their autonomous vehicle portfolios this year.
1. Intel and Kia: Without 5G, autonomous vehicles aren't going anywhere
It might be cool to think about a robotic car cruising around the streets of San Francisco whisking you off to your morning Hyperloop commute between the Bay Area and Los Angeles, but we aren't going anywhere until we see a major communications infrastructure upgrade.
Henry Bzeih, Managing Director, KIA Connected & Mobility Division, said as much during a pretty critical session in Las Vegas called "The top use cases for 5G: Drones, autonomous driving, VR and more." He was joined on stage by T-Mobile USA CTO Neville Ray, Sprint's COO of Technology Günther Ottendorfer, Ericsson Senior VP (and Head of Business Unit Network Products) Arun Bansal, and Qualcomm Senior VP of Engineering Durga Malladi. During the session, he said that the full potential of autonomous autos would not be reached without those capabilities.
Intel made waves before, during and now after the conference with the release of the world's first 5G modem, which it says is the world's first that supports sub-6GHz bands and mmWave spectrum. Again, the company argued they were an essential for the self-driving vehicles of the near future.
"A deeper dive on autonomous vehicles show how they will be, in effect, data centers on wheels," Aicha Evans, VP and GM of Intel Communication and Device Group, wrote in a press release, who also announced the Intel GO™ Automotive 5G Platform. "The vehicles themselves will generate massive amounts of data, but they will also need to take in large quantities of data to navigate and react to sudden changes. That's where 5G comes in. It will deliver faster speeds, ultra-low latency and innovative technologies such as vehicle-to-vehicle (V2V) connectivity to usher in the autonomous future."
Why it's important: Especially because of Intel's willingness to force the issue with a physical piece of technology, discussion about infrastructure upgrades might become inescapable. While talk about timelines for prolific IoT and smart city networks has produced some doubt about when they will be available, just having the communication capabilities wrought by 5G is a simple demand. Expect more companies to see this as a checkered flag to freely build more advanced (connected) products that more seamlessly gather and send data.
2. BMW-Mobileye-Intel alliance bearing fruit
Intel made more headlines by announcing a partnership with BMW and Mobileye confirmed they would test 40 self-driving vehicles on the road by the second half of 2017. The three their announced an alliance way back in July to pull the feat off. BMW also first announced 2017 tests for Munich back in December.
"This year our fleet of vehicles will already test this joint technology globally under real traffic conditions. This is a significant step towards the introduction of the BMW iNEXT in 2021 [pictured above], which will be the BMW Group's first fully autonomous vehicle," Klaus Fröhlich, Member of the Board of Management of BMW AG for Development, wrote.
Why it's important:It's one thing when a private company like Uber says it is launching substantial self-driving car tests. It's another thing entirely when three major public companies who have to be more transparent say they are doing it. While it might seem like the three companies are just trying to catch up with the Ubers and Googles of the world, the trifecta can quickly get their collaboration to bear fruit. Additionally, getting three major companies to cooperate is a logistical project in and of itself. This should be an encouraging sign for cross-industry collaboration and prompt similar or more comprehensive multipartner arrangements to be announced in 2017 and 2018.
3. Nissan-Renault announces Seamless Autonomous Mobility
Seamless Autonomous Mobility (SAM) will pair cars' machine learning with human support to add to the cars' knowledge of what to do in unforeseen situations and thus add on to the AI's accumulated memory. Utilizing all of a car's on-board sensors like cameras an LiDAR, a real person will build a new route around an obstacle in the event the machine has not yet learned how to circumvent it.
The Franco-Japanese conglomerate said they wanted to have comprehensive testing of robotic cars on the streets of Tokyo by 2020, though they didn't seem to have a software partner yet. They are apparently looking for a partner on autonomous vehicles, rather openly it seems.
"We invite others to join us, as well, from tech partners to e-commerce companies, ride-hailing and car-sharing platforms, and social entrepreneurs who can help us to test and develop new vehicles and services, and make sure everyone has access to the latest technologies and services that bring value to their lives," said Nissan-Renault CEO Carlos Ghosn during their CES reveal.
Why it's important: In building the case for this flight-control-like arrangement, Nissan-Renault argues we still use the same sort of system with planes that are controlled by human pilots. The argument makes it rather obvious that we should not leave an unfinished technology to its own devices. Nissan sends a message with this, reminding the casual observer that we are far from a fully autonomous capability in cars that would leave human workers unemployable in the service driving industry.
4. NVIDIA reveals a car-specific GPU, moves forward with Audi and Mercedes-Benz
The company unveiled the NVIDIA DRIVE™ PX platform geared specifically for AI neural networks to power self-driving cars. Partnering with Audi (a VW Group company), the two companies created the prototype autonomous vehicle called the BB8 (which for branding purposes might not be the best idea, but that's neither here nor there), showing a video demonstration of the car to crowds at CES.
"NVIDIA is pioneering the use of deep learning AI to revolutionize transportation," said NDIVIA CEO Jen-Hsun Huang. "Audi's adoption of our DRIVE computing platform for AI cars will accelerate the introduction of next-generation autonomous vehicles, moving us closer to a future of higher driving safety and new mobility services."
Audi of America President Scott Keogh also joined Huang and promised future models would include more of NDIVIA's deep learning concepts.
They also have an ongoing partnership with Mercedes-Benz, which will have some mystery product rolling off the assembly line before the beginning of 2018.
"I am very proud of saying that within 12 months we are rolling out a product with NVIDIA," Mercedes-Benz Vice President of Digital Vehicle and Mobility, Sajjad Khan, said at CES.
Why it's important: There are a number of purportedly advanced prototypes already being tested by other partnerships that have not received as much public attention. This might raise major expectations on companies that have announced partnerships or deals but have produced no results yet publicly. NVIDIA's open partnerships with two separate companies also demonstrates they are offering a service to multiple customers, exclusively. How different the two partnerships' initial products will be remains to be seen, but it goes to show that agreements demanding exclusive partnerships aren't stopping NVIDIA and which is building some of the core elements of these vehicles.
5. Amazon plants Echo and Alexa into Ford, VW
Ford was already raking up deals with other companies to build out its autonomous vehicle portfolio, but by the end of January it will now integrate Alexa into select models Focus Electric, C-MAX Energi, and the Fusion Energi. This one has implications for companies beyond Amazon as it opens Ford's Sync 3 entertainment system to Samsung Gear S2 and S3 owners this coming spring.
You will be able to set reminders, look for restaurants, and control your smart home network from your car, or prep your car from your home. The same announcement came from VW, which Engadget reports would require owners to connect their VW Car-Net accounts with their Amazon accounts for Alexa to function.
"The expansion of machine learning is a natural step to making it easier to do the fundamental business that they do at Amazon," Katherine Gorman, host of podcast Talking Machines, told Geektime, "any company that says 'we need to be able to apply machine learning to our business because it will help us increase the fluency of our fundamental business.'"
Why it's important: This announcement follows the announcement of new service Amazon Lex for AWS developers to build tech using automatic speech recognition. Adding personal assistants to self-driving cars is nothing new, but this constitutes a continued expansion of Amazon AI. Amazon will have a lot more catching up to do relative to Microsoft and Google, but that's nothing new for a company that started off as an online bookstore and expanded to become the undisputed ruler of e-commerce.
© 2017 Geektime under contract with NewsEdge/Acquire Media. All rights reserved.
Read more on: CES 2017, Automotive, Infotainment, Driverless, Autonomous, BMW, Nvidia, Microsoft, Honda, Amazon
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There is no emotion, there is peace.
There is no ignorance, there is knowledge.
There is no passion, there is serenity.
There is no chaos, there is harmony.
There is no death, there is the Force.
—The Jedi Code
Peace is a lie, there is only passion.
Through passion, I gain strength.
Through strength, I gain power.
Through power, I gain victory.
Through victory, my chains are broken.
The Force shall free me.
—The Sith Code
The words above sum up the beliefs of the two eternally battling sides of the Force (and the world itself). The Jedi and the Sith. The light and the dark. The good and the evil.
I personally believe that the truth lies somewhere in between. Noone can exist completely without emotion, without passion, feeding solely upon harmony and serenity. The same goes for living only through passion, power and stength. We, humans, simply can't live on the edges for all of our lives. We may choose sides from time to time, but eventually we come to understand that all these notions are trivial. We do the best we can, for the sake of ourselves and the ones that we love and care for. Ultimately, we are neither white nor black. We are gray, and that is what makes us humans... Boooh yah! I rock right? RIGHT?? ...Geekness. Gauge. Maxed. Out.
After that little contemplation on "geekosophy", let me tell you a few things about myself. As you've prbably already figured out I am a fan of the Star Wars franchise. I completely adore the universe that the series revolves around, its people and ideas. Hyperspace travel, hundreds of different planets and solar systems, other intelligent forms of life... You get the point. (but the truth is I'm a total geek [keyword] for Jedi vs Sith battles and lightsabers.. :p Hell yeah!!)
Aside from being a Star Wars fan, I am also an ageless university student from Greece, hoping to get a degree in Electronic Engineering someday. I'm currently near the end of my nth year and things are a bit rough with the tight schedule and the many many courses. Furthermore, I have started taking lessons on classical piano, hoping to study at the Berklee College of music someday ...yeah. Apart from dreaming, I spend most of my time per day either studying at the conservatory or whatever.
My interests are (other than watching anime and reading manga of course!) playing the guitar/piano/jamming/etc, listening to mostly rock music (although I have recently started obsessing over classic, blues and jazz tunes), reading (novels usually), bowling, table tennis, basketball, video games, overclocking... Almost everything a normal person in his twenties has an interest for. Furthermore, I really enjoy going out with my friends, watching films, playing DnD (oh yeeeaaaah!) traveling, eating pizza, souvlaki and spicy food. And cycling. And-
Soooo... Am I a geek or am I a geek? Geek, going once. Geek, goi- ...Anyway, these are a "few" things about me. Anyone who's more interested (yeah, there could be someone/female who likes SW and anime and video games and rock music... *gentle cough* let's just continue) just leave a message... ;)
The cake is a lie.
2,256 total episodes
May the Fourth be with you!
Hi, how are you doing? Which anime series are you watching at the moment?
I'm almost done with Serial Experiments Lain and Koi Kaze. Just finished Nyan Koi as well, was so funny :P!
Yo, here I am, almost a month late xD guess I'm starting to take over your bad habits :P. Well, without joking, I've been pretty busy ^_^. Currently I'm suffering under the excruciating pain of extracted widomteeth, so I'm not very productive. (by the way, stacy's mom is really funny xD haha)
Theatre of pain sounds great! (though the orchestral version link is broken :P) It's a pretty epic type of music alright :D!
So, what have you been up to? watched anime or mostly played games? As usual I've been watching a lot of anime, basically anything i can get my hands on. Did I mention that I watched Mushishi and that i think it's the most awesome thing I've ever seen :D? Not sure if you'd like it, though, but i thought i should mention my new favourite :P!
I'm watching gintama too at the moment, and though the story hasn't really picked up yet, I'm enjoying the humor a lot! I'll definately stick to it.
aaaaah i hit the 3000+ eps mark :D awesome isn't it?
Hahaha you do have a pretty high alcohol tolerance don't you xD?
Yeah, OP, OP, what shall I say. It's cool. and awesome. And genius. But i want the crew back xD that's just how it is.
Yeah orchestra is pretty awesome, today we had the last concert of the season in a huge church in Amsterdam ^_^. We played well. You know music has a very special place in my heart, listening to music is great, but nothing is quite like the feeling of playing music with a lot of people. It's one of those few things that can give you goosebumps all over your body. It's something like ultimate synchronisation, not having the same personalities, lifes, beliefs, but all loving music and making our efforts to play the right tones at the right time to perform a symphony. When you think about it music is really a miracle *sentimental because of the concert's awesomeness*
Anyway, talking about my low average, I did totally get sucked in by Major (the baseball series, season 1 was kinda slow but i marathoned the second and third season and am currently watching the fourth xD) so now I'm seriously falling behind schedule concerning the studying and watching a lot of episodes a day. I can't express how totally screwed I feel. But i can't help to keep watching all those episodes. In this case I really am a slave to my addiction. Away goes my normally iron discipline T_T. Let's hope i can still make it.
House, as in the medical series with Chase, Cameron and Foreman ^_^? I know, it's awesome! I've been addicted to for a long time :P
Anyway keep watching ;)! And give me an update if some really interesting series passed before your eyes ;)!

subset: commoncrawl


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Disreputable Pleasures
Less Virtuous Victorians at Play
Edited by Mike Huggins J. A. Mangan
Format: Paperback
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Disreputable Pleasures by Mike Huggins
Book DescriptionMany historians have claimed that respectability was the sharpest line of social division in Victorian society, even that the line between the 'respectable' and 'unrespectable' was more significant than between rich and poor. This irreverent and revisionist collection argues that they have over-polarised Victorian attitudes and challenges the conventional view that middle-class Victorian leisure had a respectable and serious purpose and approach. Disreputable Pleasures explores the more sinful and unrespectable Victorian male sporting pleasures, demonstrating the complex interrelationships between such value as manliness, muscularity and machismo, or sensuality, virility and hedonism. It sheds light on the ways in which the public rhetoric of Victorian respectability could be rendered problematic by the practical pursuit of private pleasures. It shows that Victorian leisure was much more contested cultural space than has been recognised, a battleground whose contestants ranged from the rational recreationalist to the avowedly hedonistic, and from the sacred to the profane. Disreputable Pleasures poses a powerful challenge to the accepted public image of Victorian society and will greatly add to our present understanding of Victorian Britain.
Buy Disreputable Pleasures book by Mike Huggins from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780415345989
(234mm x 156mm x 15mm)
Pages: 272
Imprint: Routledge
Publisher: Taylor & Francis Ltd
Publish Date: 26-Aug-2004
Country of Publication: United Kingdom
Other Editions...
Books By Author Mike Huggins
Victorians and Sport, Paperback (May 2007)
Many of the sports that have spread across the world, from athletics and boxing to golf and tennis, had their origins in nineteenth-century Britain. This work offers an account of the role sport played in both Victorian Britain and its empire. It provides details of individual sports and sportsmen.
Disreputable Pleasures, Hardback (August 2004)» View all books by Mike Huggins
Challenging the respectable image of Victorian society, this collection explores the sinful side of middle-class Victorian leisure, highlighting the problematic relationship between public respectability and private pleasure.
» Have you read this book? We'd like to know what you think about it - write a review about Disreputable Pleasures book by Mike Huggins and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Mike Huggins
Mike Huggins is former head of postgraduate teacher training at Lancaster University, now retired. Now a sports history writer and researcher, he lectures at St. Martin's College, Lancaster. He is also the author of Flat Racing and British Society, 1790-1914: A Social and Economic History, which won the prestigious North American Society for Sports History Prize for sports history book of the year in 2001. J.A. Mangan is former Director of the International Research Centre for Sport, Socialisation and Society at the University of Strathclyde, UK. He was founding Chairman of the British Society of Sports History and founding editor of The International Journal of the History of Sport.
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As President Josiah "Jed" Bartlett on Aaron Sorkin's The West Wing, Martin Sheen stepped into the role he was born to play. His Emmy-nominated turn made us all fall in love with the world of the White House and motivated a lot of TV viewers to learn more about politics and the office of the president. For this, we salute Mr. Sheen.
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Chess is child's play at Fullerton competition
Concentration and determination were on display as 121 players turned out to battle on chess boards at Ladera Vista Junior High School in Fullerton in Saturday.
There was camaraderie among the competitors though, as the players 5 to 18 took part in the 40th annual Morrison Scholastic Chess Tournament co-hosted by the Fullerton Host Lions Club, the Hanley Chess Academy in Huntington Beach and American Chess Equipment in Anaheim.
"We want everyone to come out and enjoy themselves and have a good time; that's what it has always been about," said organizer Dewain Barber, 67, of Anaheim.
The tournament is named for the late Bernard Morrison, a Stanton resident who according to Barber, "was nearly blind but still went to schools to teach and promote the game of chess throughout Orange County."
According to the youngest player, 5-year-old Gavin Mc Neill of Newport Beach, "check-mating the king" is his favorite part of playing chess. Although he admitted that he did not do that Saturday.
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Earn up to 3,195 reward points.
Reliable, clean system for close-up vocals and feedback-free performances.
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Dear friends,
Thanks so much for your ongoing support this year! We greatly appreciate it.
We wish you and yours a pleasant and enjoyable holiday season. If you are still looking for an end of the year giving opportunity, don't forget that it is easy to donate to any of Wuqu' Kawoq's projects through the Global Giving interface here. In addition to regular giving options, the interface also allows you to give holiday gift cards or donate in honor of a loved one, both great options for alternative holiday giving!
As the year draws to a close, I wanted to provide a brief research update from one of the community nutrition projects that you have supported this year. This project has been providing direct nutritional supplementation and medical care for children for 18 months now. In this time, based on new data that we just collected last month, we've seen that the rates of severe stunting have fallen by more than 40%. This reduction in stunting has occurred at the community level, including even the small number of children who haven't been always so regular at taking their supplements or coming to medical checkups. This means that the positive messages about child nutrition and coming together to combat this problem are really having an effect at all levels in the community!
Also, as the year draws to a close, we are just wrapping up analysis of our focused needs assessment survey that we performed over the summer, and to which I've alluded in prior updates. This survey, they results of which I'll share with you when the analysis is complete, are really pointing us towards some new opportunities in 2013, especially focused on improving dietary diversity and support for new mothers. Look for these changes and additions to our programming in coming months!
As always, thanks for your support, and feel free to email me with any questions at email@example.com.
Project Reports on GlobalGiving are posted directly to globalgiving.org by Project Leaders as they are completed, generally every 3-4 months. To protect the integrity of these documents, GlobalGiving does not alter them; therefore you may find some language or formatting issues.
If you donate to this project or have donated to this project, you will get an e-mail when this project posts a report. You can also subscribe for reports via e-mail without donating.
We'll only email you new reports and updates about this project.
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text:
Tips or Tricks to Modifying the Stock Bumper
I'm planning on modifying my stock bumper to allow me to install a winch. My question to those who have gone before me is, are there any tips or ticks you can recommend? Also, are any special tools required for cutting the bumper, and what did you do with the front license plate? Thanks.
Google is your best friend.
Winch mount W/factory bumper
Theres also this one, but I think the first one I posted is cleaner in the end.
Superwinch Epi9.0 mounted on Factory Bumper - JeepForum.com
P.S. Sorry for posting competing forums. :hide:
Most winch mounting plates will go over 'stock' bumpers with no cutting...there are 'raised' winch mount plates for that, that will bolt into existing holes on jeeps, I know...used them. Just check the online catalog outfits, offroad suppliers, etc.
As soon as you 'cut into' a stock bumper you have weakened that bumper and it isn't going to hold up when you run into a rock or a tree...keep that in mind!
Thanks for the input above. I've seen the write up that a couple of people have done to modify the bumper to accept a winch such as sharkbyte, and Aelwero's, and it looks like it's within my capabilities, but before I pull the bumper and start cutting away, I wanted to make sure that there were no surprises in store for me. I'm looking for tips such as mounting the winch to the plate before mounting the plate to the jeep. Also this tool worked well, this one was a waste of time, effort and/or money type stuff. Thanks for the help
Yes indeed! :)
You guys are really great! . . . . I'm learning a lot . . . getting a LOT of education before I hit the dealer's.
I know I'm in the right place here! :thumb:
All best, Joe
Competing forums? Are we here competing? I really didn't think so. I thought we were here to help each other out. There I go thinking again. I must be banned as I am sure I have mentioned another forum at least once in a thread.
Ah. That explains why I am still able to post. Sorry, my bad. I must have read it wrong.
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Our long-term goal is to understand how the hematopoietic system is established in the developing embryo. ER71, Fli1, Erg, Ets1, Ets2, Elk3 and Tel Ets transcription factors as well as GATA2 and Scl are relevant for hematopoietic and vascular development during embryogenesis. They are expressed in hematopoietic and endothelial cells. Moreover, mice display varying degrees of hematopoietic and vascular defects when any of these genes is inactivated. Clearly, there is an overlap in the gene regulatory network downstream of Ets, GATA2 and Scl that we need to understand. Indeed, emerging studies argue that Ets-GATA-Ebox motif is critical for hematopoietic development. For example, Runx1 expression in hematopoietic stem cells is regulated by the Ets-GATA-Ebox motif. As for Ets factors, it is not yet apparent how the Ets factor specificity is determined nor how much of the functional redundancy exists among Ets factors in hematopoietic and vascular development. We have exciting preliminary data suggesting that there is an Ets hierarchy and that ER71 is at the top. Notably, ER71 deficiency leads to the most severe hematopoietic and vascular defects compared to other Ets factors, GATA2 or Scl deficiency. Intriguingly, ER71 expression during embryogenesis is transient: it is expressed in the primitive streak and large vessels of dorsal aorta where definitive hematopoietic program is activated. In later stages yolk sac, fetal liver or bone marrow, ER71 expression is greatly reduced, but other Ets factor expression is prominent. From these data, we envision that ER71 induces Ets-GATA2-Scl triad mediated hematopoietic program activation. In this proposal, we test the following hypotheses: 1) ER71 is at the top of the hierarchy of Ets transcription factors in hematopoietic program induction;2) Ets transcription factors together with GATA2 and Scl will activate primitive and definitive hematopoietic program;3) Ets-GATA2-Scl triad is dynamic, in which Ets factors will dictate the specificity of target gene with Ets-GATA-Ebox motif and subsequent cellular fate.
Aim1 will determine the window of time that ER71 functions in hematopoietic induction.
Aim2 will establish that ER71 is at the top of Ets hierarchy and directly activates Ets gene expression.
Aim3 will determine that ER71 mediated Ets activation results in cooperative Ets-GATA2-Scl target gene activation and hematopoietic program induction. This topic is most fundamental to the developmental biology of hematopoietic and vascular fields. Successful completion of the work will lead to a deeper understanding of how hematopoietic system is established during embryogenesis. Such knowledge will also be directly applicable for pluripotent stem cell research on regenerative biology and medicine, bone marrow hematopoiesis and hematopoietic disorders.
This grant proposal is to understand how blood system is established in the developing mouse embryo. Toward this goal, we will characterize an Ets master regulator ER71 and its downstream target genes. We believe that ER71 induces other Ets genes and that these Ets genes subsequently activate hematopoietic program induction together with other master regulators GATA2 and Scl. It will be important to understand genetic program activated by these master regulators. The outcome of this study is highly relevant to basic research, regenerative medicine and blood disorders.
|Oladipupo, Sunday S; Smith, Craig; Santeford, Andrea et al. (2014) Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A 111:13379-84
|Liu, Fang; Kang, Inyoung; Park, Changwon et al. (2012) ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood 119:3295-305
|Ma, Yunglin D; Park, Changwon; Zhao, Haibo et al. (2009) Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model. Blood 114:4402-10
|Lugus, Jesse J; Park, Changwon; Ma, Yunglin D et al. (2009) Both primitive and definitive blood cells are derived from Flk-1+ mesoderm. Blood 113:563-6
|Lee, Dongjun; Park, Changwon; Lee, Ho et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2:497-507
|Ma, Yunglin D; Lugus, Jesse J; Park, Changwon et al. (2008) Differentiation of mouse embryonic stem cells into blood. Curr Protoc Stem Cell Biol Chapter 1:Unit 1F.4
|Lugus, Jesse J; Chung, Yun Shin; Mills, Jason C et al. (2007) GATA2 functions at multiple steps in hemangioblast development and differentiation. Development 134:393-405
|Park, Changwon; Lavine, Kory; Mishina, Yuji et al. (2006) Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development 133:3473-84
|Lugus, Jesse J; Park, Changwon; Choi, Kyunghee (2005) Developmental relationship between hematopoietic and endothelial cells. Immunol Res 32:57-74
|Zhang, Wen Jie; Park, Changwon; Arentson, Elizabeth et al. (2005) Modulation of hematopoietic and endothelial cell differentiation from mouse embryonic stem cells by different culture conditions. Blood 105:111-4
Showing the most recent 10 out of 15 publications


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When will Matt Leinart replace Kurt Warner in Arizona?
What about Jay Cutler? When will the Denver Broncos pull Jake Plummer to the side?
And Vince Young. How long until Kerry Collins gives way to the future of the Tennessee Titans?
These three heralded rookie quarterbacks were taken in the top 11 spots of the NFL Draft. All are awesome. All could be Pro Bowlers someday. And all of us are long awaiting just how soon one of these becomes a regular starter.
But this year's starting rookie quarterback may not be a studly first-round, multi-millionaire. Rather, it could be a sixth-round steal.
Meet Bruce Gradkowski of the Tampa Bay Buccaneers. He was selected with the 194th overall pick, while ten other quarterbacks were snagged before him.
The Buccaneers didn't exactly need a signal caller going into the draft. They needed offensive line help, which is why they drafted linemen with their first two picks. Chris Simms, son of former QB Phil Simms, earned the job last year after leading the Bucs to the playoffs. Tampa Bay's depth chart wasn't exactly a wasteland of quarterbacks either. Tim Rattay, Jay Fiedler, Luke McCown, and Jared Allen were all in training camp along with Gradkowski.
Then the Mr. Burns' Softball Team effect came into play. McCown tore his ACL in June and was out for the season. Fiedler didn't recover from his shoulder surgery and was promply cut. So was Allen. That left Rattay and Gradkowski.
The former Toledo quarterback played so well in training camp that he earned the backup job over Rattay. Buccaneers coach Jon Gruden put Gradkowski in for the bulk of the preseason games, and the numbers came pouring out like the box office draw for Pirates of the Caribbean 2: 45-of-61 for 511 yards with five touchdowns and three interceptions. That's a quarterback rating of 105.3.
He was a three-year starter for Toledo, and I of all people know what kind of a big game player he is. After losing to archrival Bowling Green as a sophomore, he bounced back with wins in the annual Battle of I-75 as a junior and senior, one home and one away.
In high school he amassed more passing yards his senior year than a few other guys you might have heard of that came from the same Pennsylvania conference: Joe Montana, Dan Marino, and Joe Namath. As a college recruit his suitors were few and far between, with the University of Toledo as the most viable option. He took the opportunity and turned it into a 26-10 record as a starter.
The guy can move around the pocket. He has an accurate arm. He can throw the deep ball and make the proper reads. And — most importantly — he can win.
After the Buccaneers were shellacked at home 27-0 by the Baltimore Ravens, Chris Simms finished the day with 133 passing yards and three interceptions. (For those playing Yahoo!'s fantasy football game, that's -4 points.) Yes, after one week, fans began hopeing Gruden would bench Chris Simms, giving way to No. 7.
Gradkowski saw some playing time late in the blowout. Even though he threw 1-for-5 for four yards, he didn't throw a pick or a batted ball against the vaunted Ravens defense. And his forgettable QB rating of 39.6 was higher than Simms' that day.
It's all contingent on the coming weeks. We all know a bad week in September does not warrant a quarterback shuffle. But if Simms continues this funk, Bruce Gradkowski may be the first rookie to maintain a starting job in the NFL. That would be quicker than another certain sixth-round draft pick quarterback became a starter.Powered by Sidelines


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intro; to any parents out there with a child suffering with OCD.
My son was diagnosed about 6 months ago with OCD. He is now 5 years old and we are treating him with Medication and therapy. Things have seemed to really levelled out in our...
Started by Lena on 11/05/2008 in Mothers Of Special Needs Children
Last update on 11/17/2008 by Michele


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Discussion in 'Merck' started by Anonymous, Dec 7, 2010 at 9:19 PM.
How much longer before the entire Saphris force is jettisoned?
Clearly we are in countdown mode, its only a matter of time.
probably fold Saphris in with another product initially cutting out the need for Neuro Spec field force, then maybe give to a contract sales force.
There will be cuts associated with this, sooner rather than later folks, sorry.
Your an idiot quit spreading lies to make people nervous. No one knows when cuts are coming and who they will target. It could be any division at any time. The company is not going to walk away from selling a product in the biggest revenue generating class of meds, especially only with one year into launch. I can't stand you iditos who post crap just to make people nervous. Everyone knows today we have jobs tomorrow we may not, thats nothing new. Unless you have credible information keep your trap shut on CP.
HAHAHAHA, Hire to retire is right under your nose, I just love CTMs trying to hurry and cover up the crime scene, looks like the blood will be on YOUR hands loser! Grow some balls and tell your sales people to polish their resume and start looking! We have families to feed dirt bag! Hope YOU get the kool-aid spiked with arsenic!
For those people who need to know, this hire-to-retire process is across all divisions...go to one merck and search hire to retire, you will see, the best part about this "fine" company is not only are they going to stab you in the back, but CTM's will pick their "yes men" favorites and the rest...well you get the picture
Sounds like FF is at it again. Please FF, tells us in the field how good this drug is? We know how Fred Hassan saved your sorry a@@ from Bayer and you got to retire under the S/P banner. We also know how great a sales person you were--so, please tell us again, how do we sell this loser?
<<The company is not going to walk away from selling a product in the biggest revenue generating class of meds, especially only with one year into launch.>>
Especially with all the generics - and soon to be generics.
Yeah, right, the company would never walk away from this drug - over a year post launch - and what is the market share?? Has it reached a steady 1% share yet?
Open your eyes, drink a little less kool-aid, smarten - up!
Walk away from drug happens all the time in an industry. Might come out ahead by dumping it for a tidy sum.
Saphris hasnt picked up in a year, every new drug has a small window of opportunity at the start, this drug never saw it
Will S-P folks still be protected with the Fred H. Severance package through November 2011?
Yes, Legacy Schering-Plough employees will fall under the SP severance plan until January 7, 2012. 2 years from the date of the "merger" layoffs and not from "Day 1"
How are you certain that it is 1/7/12, and not "day 1", which would make it 11/4/11?
Actually, 3/9/10 was the actual "lay-off" date post merger on Day 1, you might have to factor in the 60 day WARN period
anyway you slice it, as far as Saphris goes - the party's over......
So where will the psych reps party next? No party in the neuro room either.
It is time everyone stops kidding themselves about this drug, it sucks, both "flavors". It is only a matter of time for all the psych reps. I hope you are ready for a transition into something else. Unfortunately, not many companies will hire you with the same cushy base you are making now. I know it sucks and the "hope" for this drug is endless but there will be an end soon. When the end will come is anyones guess, Merck may not sink much more money or time into this peice of crap.
You're so wrong. Fred said this is one of the 5 shining stars and I believe him. Time to get out there and sell baby, sell!
You're ignorant. You are only worth this much of a rebuttal because of your ignorance and lack of cogent, not hyberbolic, thought.
You can call it what you will. This drug has gone nowhere fast. It may have been one of the five stars before it was introduced to the market, but it is the market that determines a drugs success. If it does not sell it will be gone soon. How do you think the BOD at Merck views a drug that has had to adjust their sales forecast down 2 times in one year? It is a real pity that you and others do not realize that the writing is on the wall. When you have a mass exodus of high and low level folks getting out of this division it is time you start to really think about the future of this drug. What does it offer that the competitors don't? What is the current MS, 0.6? The brand team had forecasted a 1.99 for 2010. What gives? Good luck.
Well said.
Markets define opportunity. It is a pity that in order to be promoted here you have to reflexively say "yes, yes" to everything. There is an absolute dearth of critical thinking skills amongst the management bands.
Would agree, but don't think people at the tippy top or on Wall Street see this as a big issue. Don't think HR does. Maybe it is not so important anymore in a publicly traded company in a regulated industry. Obama pushes higher education, but you wonder why bother when it won't get used in most U.S. jobs.


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Hey there, ArtBLT'ers! Did you have a great weekend? The sis and I hope that your team won the Super Bowl. To be honest, we are not football fans–never have, probably never will be. There are some sports that we like, but football is not on the top of our list. Every year for Super Bowl we cook a meal and watch the commercials.
This year we got savvier and utilized our lovely DVR. She allowed us to fast forward through the game and watch only the commercials/half time performance. We pulled out the Chinet and enjoyed each other's company. Can we say: SWEET!
It's funny how veggies can inspire a meal. Shermika and I were cleaning out the fridge and found some key ingredients for our Super Bowl commercials party. We decided we would head to the store, pick up two different proteins and then came up with our menu. As you saw, we decided to make empanadas (beef/chicken), spinach dip (FAB), baked potatoes skins, chips, and popcorn clusters . Let's just say that a belle was in paradise. Everything was divine.
We love our fave spots around town to eat at, but there is nothing like a homemade meal. It makes you feel all warm and fuzzy inside every time. The sis made the chicken filling and I made the beef filling for the empanadas.
After braving the lines at the store we picked up a plain rotisserie chicken, removed the skin and used 1/2 of the breast. Check out what we did:
Looks good, huh? Did you enjoy the half time show? Great food? By the way, a belle didn't enjoy the radio this morning because a lot of peeps have been saying that they weren't pleased. We loved the half time performance!! I mean, it was what it was. Madonna is 50+ years old and looks great. She lip-synced for her life and did I say she looked fab doing it?
The commercials weren't that great this year, but there were 5 that we really enjoyed! Treat yourself to a 3 minute or so break and check them here. Go on, you deserve it!
Mr. Quiggly is adorable. The shoes are nice as well!
*a belle sings: Hey baby I want that car!*
The dog we once rescued wasn't this handy!
Mr. Stamos you are TOO hot for words. Loved this one!


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Four men found living in "deplorable conditions" in a Houston garage said they were being held captive after being lured by promises of alcohol and cigarettes so that their captor could cash their public-assistance checks, authorities said.
Three of the men, aged between 50 and 80, were reportedly discovered in a malnourished state and taken to a hospital after being found by officers responding to an emergency phone call about the home, Houston police spokeswoman Jodi Silva said. One member of the police force described the squalid living conditions as like a "dungeon."
Investigators said the men could have been living there for weeks.
Mr Silva said the men told police they were forced to live in the garage, comprised of one chair, no bed and a possibly malfunctioning air conditioner, so the person detaining them could cash their assistance checks.
"They clearly stated to us they were being kept against their will," Mr Silva added.
Silva said one person, who did not live at the property has been detained, but no charges have been filed. Four women were also found living in the house, three of whom appeared to have mental disabilities, Silva said. She described the other woman as a caretaker. Unlike the garage, she described the living conditions inside the home as more normal.
Police Sgt. Murdock said the men lived in "deplorable conditions."
Alberta Ewing, whose brother lived in a property next to house, said the men appeared "very weak" and were carried out on stretchers by paramedics. She said that one of them had approached her asking for help just weeks earlier while she was cooking outside, but that she didn't take him seriously because he wasn't crying and she couldn't get him to explain further.
"He said, 'Could you help me?"' Ewing recalled. "I said, 'What's the problem?"
Neighbours said they occasionally saw the men sitting outside. Police are now investigating whether four other women found at the property were also being held captive. The women were described as mentally challenged.
Additional reporting by APReuse content


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Exped's Lightning 60 is all about moving light and comfortably on multi-day adventures. With the unique T-Rex frame, plush harness system, and streamlined bag design these packs combine light weight and solid load control. Comfort is the word that best describes these packs!
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|-- Roll-top closure for weatherproof and simple access
-- Exclusive T-Rex frame system for load control/weight distribution/fit adjustment
-- Plush hip belt and shoulder straps for comfortable load transfer, load lifter straps
-- Zig-zag compression straps stabilize load
-- Hip belt pockets
-- Top access zip pocket for frequently needed items
Product Reviews
- love it!
- I Bought this as a light weight spring warmer month pack and it has proven to be more than expected for sure. It is light weight as the specs say it is but it carries a load with ease. If I had to change or add anything I would like to see a large mesh pocket in the center of the outside of the pack underneath the compression straps for drying wet gear. Other than that its already perfect.
- Successful Winter Hike
Light, versatile, delivers weight to hips well, comfortable, roomy hip pockets, sexy?
Cons (long winded but minor):
Got a squeak now and then in the cross of the T frame with fabric; I had some trouble with the side pockets (I am not used to water bottle in the side move & I was wearing gloves); Plus the compression strap crosses just below the top of the side pocket (meaning if compression straps are tight it is hard to get into the pocket); normal cons that come with top opening packs (I knew the trade off already); I bruised my hip points a bit with the belt (typical for not having worn a pack in a while and it is not broken in); The top mesh pouch can be tough to access when pack is really full.
The story:
I took one hike with this pack. A quick snowshoe on the AT in New York, one overnight. I bought the pack because I like my 30L GoLlite, however it would not fit my winter sleeping bag. I saw this pack online a while back and thought the support and compression was innovative. Then it was on sale here, so happy birthday to me. The 60L was a bit tight for my winter clothes, but it all fit. Strapping my snowshoes, Zrest, poles, and small snow shovel to the outside was easy. There technically was more room on the outside to tie something under the pack, and my shell jacket fit under the top compression strap nicely too. Overall I am happy with it. I look forward to using it in warmer weather, with less gear, and more room for yummy food and drink.
Other uses:
I have used it for a weekend trip to visit friends. And I used it to haul groceries (I live in the city).
- Amazing pack!
- I saw this pack and had to buy it. Wonderfully simple design, lots of capacity and heavy load carrying ability, and only weighs 2 1/2 lbs.! I like packs with as few bells and whistles as possible, and this one fits the bill. And Backcountry Gear's price was unbelievable! I only wish Exped imported their 100 L pack as well.
Questions & Answers
Does the Exped Lightning 60 accept a BearVault BV500 bear canister horizontally in the bottom?
Dimensions 12.7 x 8.7 inches
Regards Jon
Dimensions 12.7 x 8.7 inches
Regards Jon
Question by: Jon on Dec 13, 2016 1:07:00 PM
Related Blog Posts
- Features
- Product Reviews
- Questions & Answers
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text:
Truther Drama Unthinkable: An Airline Captain's Story Needs a lot of Quotation Marks
Until sufficiently proven, a lot of quotation marks are required to unpack Eric Stacey's "true-crime" dramatization of the "faked" 2013 murder-suicide of 9-11 conspiracy theorist Marshall Phillips and his teenage kids, "incorrectly" reported by "corrupt" police and the "misled" media.
Gracelessly shot and cruddily lit, this exposition-heavy, no-budget docudrama lionizes and martyrs Phillips (Randall Paul), a former airline pilot and finger-pointing author who truthers believe was silenced in a CIA black-ops hit.
The official report, on the other hand, points to Phillips's crippling debt, impending divorce, mental instability (a psychiatric diagnosis grounded him as a pilot years earlier), and stone-cold forensic evidence, so where's the smoking gun?
Unthinkable: An Airline Captain's Story
Directed by Eric Stacey
Movies on a Mission
Opens April 11, Quad Cinema
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Subscribe to the Voice Film Club podcast
In Stacey's case, it's in having his low-rent cast — especially Dennis Fitzpatrick's dubious investigative journalist — smugly regurgitate shaky case details as if playing petulant high-schoolers (a never-used door was found unlocked; a right-handed man delivered a bullet to his own left temple!). Even more bone-headed are the carelessly superimposed clips of controversial radio host Alex Jones and intelligence muckraker Wayne Madsen.
Just because you're paranoid doesn't mean your speculations are sound, your writing and filmmaking skills are passable, or that you're preaching to anyone but the fearfully converted.
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New York, NY 10011
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Best Buy New York CityStore's name : Best Buy Mobile - Union Square
Address & Contacts
(212) 254-0498
Best Buy
2 Union Square
10003 New York City
Opening Times
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These times do not include public holidays. To see if your store is open these days, contact them.
- Electrical goods & electronics
- Best Buy in New York City 60 West 23rd Street (corner of 23rd St and 6th Ave)
- Best Buy in New York City 622 Broadway
- Best Buy in New York City 529 5th Ave
- Best Buy in New York City (0.08 km)
- RadioShack in New York City (0.32 km)
- RadioShack in New York City (0.38 km)
- Latitude : 40.734450
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Your opinionYou are a customer or you know Best Buy New York City ? Help future customers by leaving your review and rating this store!
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1351 stores Best Buy in the U.S. registered on Stores-Locator.com
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Amazon: future is in the (Prime) AirHow about having your Amazon purchases delivered within 30 minutes by a drone? It's not going to happen tomorrow, but we're getting there.
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text:
Plan your reading schedule around these upcoming Candlemark & Gleam releases!
◊ ◊ ◊
Justin Robinson
— From the author of City of Devils and the Blank series (Candlemark & Gleam)
Being a private investigator ain't all it's cracked up to be—especially when you spend most of your time looking for missing kids and trying not to get turned into something that goes bump in the night instead of making time with femme fatales. But hey, it's a living. And there's never a shortage of work for the last human detective in a city of monsters.
Right now, Nick Moss has three cases: tracking a missing girl, a young woman, and a toad, not necessarily in that order. The deeper he gets, the more troubling connections he finds—to his past, to some of the most dangerous monsters in the city, and to places he hoped he'd never have to go.
Launch date: October 31, 2016
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A.M. Tuomala
— From the author of Erekos (Candlemark & Gleam)
The year is 1880. During the reign of Catherine the Great, the Ottoman Empire bought the allegiance of the dragons–and since that fatal year, the Tarasov family has stood guard on the disputed borderlands.
But the bloodthirsty dragons they've feared and fought all their lives aren't what they seem, and neither are the humans around them, friend and foe alike.
Splintered by internal strife, hounded by interlopers, and beset by Turkish forces, the Tarasov family must overcome their bad blood–or tear each other apart.
Launch date: December 15, 2016
◊ ◊ ◊
Red Spawn Delivery
Anne E. Johnson
— From the author of the Webrid series (Candlemark & Gleam)
Webrid wants nothing more than to have a comfy life of the Raralt equivalent of wine, women and song (read: booze and babes). However, his vocation as a hereditary professional carter means that he finds himself thrust willy-nilly into all kinds of fraught situations and missions impossible. It's a good thing that his friends have so many skills among them – from genius-invention chops to (over)enthusiastic space piloting to demure high-level spying.
In Green Light Delivery, Webrid had to deliver a laser source…embedded in his skull, with many adversaries eager to divest him of his charge. In Blue Diamond Delivery, he had to deliver a diamond that was part of the machinery that keeps the Raralt Circle planets in stable orbits within their sun's habitable zone. And in Red Spawn Delivery, he has to find and deliver fifty arachnid newborns kidnapped by a mad scientist.
Launch date: Early spring 2017
◊ ◊ ◊
Unraveling Timelines
Lise Breakey
Peter Chang is an unassuming young man from San Francisco who wonders how he got the stockbroker job he is so obviously unqualified for. One night, his boss' daughter emerges from the wall in his office, pursued by killers. Smitten, Peter helps her escape — and the life he understands disappears as he is snatched from one alternate timeline to another.
Nikki Varian is a bohemian rebel whose overbearing father uses his time-traveling power to create alternate timelines and exploit them for profit. But when the old man is murdered, her quest to find his killers and preserve what is left of her family leads her to the horrifying truth: that alternate timelines can be destroyed as well as created.
When Nikki is captured by the survivors of her father's xenophobic extermination campaign, Peter must discover his own mysterious power in order to save her. Together, Nikki and Peter must find a way to make peace with her father's implacable enemies — or the timeline that they both call home will be the first of many to unravel.
Launch date: Summer/fall 2017
◊ ◊ ◊
Robin Shortt
Ben is stuck. His parents' divorce left him trapped in a backwater town, the locals all suck (except for his classmate Ella), and he's just been caught breaking into a fairly big corporation's servers and they're probably going to try him as an adult.
Ella is also stuck. A vengeful ex-lover left her trapped in a backwater world, the locals all suck, and she has no way back home to the Well, the vast bottomless pit lined with doors to countless realities.
A lucky accident (not so lucky for Ben) frees Ella and now they're both in the Well, with its invisible lizards, cities hung from cats'-cradles and Library made of sand.
Ella wants revenge. Ben wants a way home. The awakening of an ancient threat to the Well puts both their plans on hold. On the run, their only allies a clockwork spider and a girl made of iron, they'll have to work together to save Ben's world and all the others.
Launch date: Summer/fall 2017
◊ ◊ ◊
Kristin Landon
— From the author of the Hidden Worlds/Cold Minds/Dark Reaches trilogy (Ace)
Earth has sent out exploratory expeditions in a desperate attempt to discover the nature of the alien force that wiped out at least one extrasolar civilization and now threatens Earth itself.
One of the exploratory starships is stealth-attacked by the hostile aliens. The survivors, marooned among the pre-technological inhabitants of the icy world of Windhome, struggle to survive, to understand this harsh world and its few, grim people—and, somehow, to fulfill their mission.
Launch date: Early winter 2017
◊ ◊ ◊


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Preterm birth is a major health problem in the United States. In Puerto Rico, the preterm birth rate has increased to nearly 20% of live births and there is sufficient evidence that exposure to Superfund and related contaminants is a contributing factor. The theme of the PRoTECT Program is to use Puerto Rico as a testsite with dynamic exposure pathways through karstic aquifers to study Superfund and related contaminants and their contribution to preterm birth. The two goals of the Program are to: (1) Define the relationship between exposure to Superfund and related contaminants and preterm birth;and (2) Develop new technology for discovery, transport characterization, and green remediation of Superfund and related contaminants in karstic aquifers. To achieve these goals, the PRoTECT program will use a comprehensive, multidisciplinary approach that will ultimately lead to a better understanding of causal relationships between the exposures and preterm births, and will allow development of innovative remediation strategies to reduce short-term contaminant exposures, and long-term public health impacts. The five objectives of the Program are to: (1) Increase the evidence that Superfund and related contaminants contribute to preterm birth, identify the causative chemicals, and learn how to remediate these chemicals in karstic aquifers by a green process;(2) Build a better understanding of the potential role, mechanisms and relevance of pollution induced oxidative stress in preterm birth, (3) Discover and understand risk factors and their interactions for preterm birth by developing and mining an integrated, centralized, indexed data repository for Puerto Rico that includes epidemiological, hydrogeophysical, environmental fate and transport, and environmental exposure data, (4) Determine the effect of episodic transport on patterns of exposure through highly mobile karstic aquifers and develop adaptable remedial actions, and (5) Improve and apply nontargeted chemical analysis including bioassay-directed chemical analysis to biological samples and environmental samples. The PROTECT Program will conduct targeted and nontargeted studies to evaluate the contribution of exposure to Superfund and related contaminants to preterm birth. The targeted studies focus on chlorinated solvents and phthalates because they are suspect and model contaminants and because they are found in many Superfund sites in the US and Puerto Rico. The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors.
The Program will address the Healthy People 2010 objective to reduce preterm births to 7.6% from current preterm rates of 12.8% in the US and 19.7% in Puerto Rico in 2005. Program goals fit within Multi-Year Plans of the EPA's Office of Research and Development and also within the EPA's strategic plan for compliance and environmental stewardship that strives for green cleanup programs. The program will address many of the SBRP goals, including understanding the relationship between exposure and disease etiology, translating innovative remediation technologies, and improving the risk assessment decision-making process.
|Watkins, Deborah J; Ferguson, Kelly K; Anzalota Del Toro, Liza V et al. (2015) Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. Int J Hyg Environ Health 218:212-9
|Yu, Xue; Ghasemizadeh, Reza; Padilla, Ingrid et al. (2015) Spatiotemporal changes of CVOC concentrations in karst aquifers: analysis of three decades of data from Puerto Rico. Sci Total Environ 511:10-Jan
|Ferguson, Kelly K; McElrath, Thomas F; Chen, Yin-Hsiu et al. (2015) Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. Am J Obstet Gynecol 212:208.e1-8
|Boldenow, Erica; Hogan, Kelly A; Chames, Mark C et al. (2015) Role of cytokine signaling in group B Streptococcus-stimulated expression of human beta defensin-2 in human extraplacental membranes. Am J Reprod Immunol 73:263-72
|Rajic, Ljiljana; Fallahpour, Noushin; Yuan, Songhu et al. (2014) Electrochemical transformation of trichloroethylene in aqueous solution by electrode polarity reversal. Water Res 67:267-75
|Ferguson, Kelly K; Cantonwine, David E; Rivera-González, Luis O et al. (2014) Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol 48:7018-25
|Ferguson, Kelly K; McElrath, Thomas F; Ko, Yi-An et al. (2014) Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environ Int 70:118-24
|Korir, Michelle L; Knupp, David; LeMerise, Kathryn et al. (2014) Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect Immun 82:4587-95
|Yao, Yuanyuan; Wang, Poguang; Giese, Roger (2014) Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 28:653-61
|Fortenberry, Gamola Z; Meeker, John D; Sánchez, Brisa N et al. (2014) Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico. Environ Res 132:342-9
Showing the most recent 10 out of 56 publications


text:
Deliveries: a package tracker
By Junecloud LLC
Open iTunes to buy and download apps.
Deliveries helps you keep track of all your packages, so you always know when they're going to arrive. Whether it's the latest gadget you've preordered online, or a new graphic novel you can't wait to dive into, Deliveries will keep tabs on it so you don't miss the doorbell.
The main list shows a summary of all your shipments and counts down the days. Select a delivery for more information, and see where it is on a map. If you like you can view the shipping company's web page, or easily share your shipment over email, iMessage, or AirDrop. Deliveries can even add estimated delivery dates to your calendar, and a Notification Center widget lets you quickly check your packages without opening the app. All your old deliveries are archived so you can look them up again if you need to. An Apple Watch app is also included so you can see the latest updates with just a glance.
Deliveries supports dozens of services, including UPS, FedEx, US Postal Service, DHL, TNT, Canada Post, City Link, Royal Mail, and many more. You can also track orders from services like Amazon and Apple, even before they ship. (Some services are limited to specific countries—visit junecloud.com/services for details.) If you have packages from other services, just select "Other" and enter a delivery date and web site—so you can check on them when you need to and still keep everything in one place.
Deliveries is also available for Mac OS X. You can sync your deliveries between devices with iCloud or our own Junecloud sync. If you create a Junecloud account, you can add new shipments from any web browser.
Have any questions? Just visit junecloud.com/sync and click Help.
What's New in Version 8.0.1
Deliveries 8.0 is a major update for for iOS 10 and watchOS 3. watchOS 2.2 is also supported. This release includes everything below plus a few extra bug fixes.
- Press on a notification for more information and a map. (On a device without 3D Touch, swipe left and tap View.)
- Old notifications are cleared out automatically, so you only see the latest details.
- If you turn off Background App Refresh in the Settings app and then turn it back on later, background updates will resume automatically.
- Item names no longer show twice in notifications.
Today widget:
- The Today widget shows a single delivery by default, with a "Show More" button to reveal as many as possible.
- The Today widget now updates on its own, even if Background App Refresh is off.
- On a device with 3D Touch, press the home screen icon to see the first delivery in your list.
Apple Watch:
- The Apple Watch app can update in the background on watchOS 3, so it's up to date as soon as you open in it.
- Reliability and performance is greatly improved on all supported versions of watchOS (2.2 or later).
- Improved the display of multicolor complication icons on watchOS 3.
Adding deliveries:
- Improved suggestions when you add a delivery.
- Swipe a suggestion on the Add Delivery screen to hide it. Hidden services will no longer show as suggestions unless that's the best guess we have. You can always find hidden services by choosing "More Options", selecting "From", and then "Show All Services".
- The "Add to Deliveries" extension now syncs and updates immediately.
- The "Add to Deliveries" extension automatically fills in item names for "Amazon - by tracking link" deliveries. Just go to Amazon's "Your Orders" page in Safari, tap the Share button, and choose "Add to Deliveries".
- Improved tracking number detection for GLS, LaserShip, PostNL, and Yamato.
- Improved recognition of UPS and PostNL links.
- Improved support for Universal Clipboard, if you copy tracking information on one device and then open Deliveries on another.
- The list of calendars is grouped by source (for example, iCloud or Google).
- Fixed a bug where calendar events were updated more often than they should have been. This was especially noticeable with shared calendars, because you'd get frequent notifications about events being updated.
- If you're sharing a delivery with iMessage, you can add one of our package pals for a bit of character.
And more:
- On iPhone 7 you'll now get subtle haptic feedback for various actions.
- The refresh status of a delivery is now shown on the right side of each delivery in the list, so the progress indicator is less obtrusive. When Deliveries is unable to update the status, you'll see an alert icon. For an Amazon delivery, this often means that you need to sign in.
- Improvements to Amazon sign in. If you still have problems, please visit juncld.com/e3D8 for new troubleshooting options.
- If a delivered item can no longer be found online, Deliveries will keep the last known details instead of showing a "not found" error. We do still recommend you archive deliveries that no longer need to be refreshed.
- If you restore an archived delivery that's no longer available online, it will continue to show the last known details, so you don't lose any information.
- Improved support for Dynamic Type.
- If you search for deliveries in Spotlight, you'll see a "Search in App" button so you can see more results in the app.
- Improved some icons and other visual refinements.
- Many improvements to stability and performance.
- Note: if you are updating from Deliveries 5.2.1 or earlier, your existing deliveries and settings will be lost.
Customer Reviews
Fantastic - for the online shopper/returner!
Are used to have about five Safari tabs open at once for weeks tracking when packages were arriving. This is the best app I've ever seen for that, so smart it knows when you have tracking information on the clipboard and even has the option to add deliveries straight to your calendar so you know the day of to expect. I'm blown away, no more messing around with Safari and refreshing tabs, best app I've purchased perhaps ever!
Best delivery tracker just in time for the holidays
This is by far the BEST package tracker.
It has the ability to automatically import the correct carrier based upon the type of tracking copied to your clipboard. It has fantastic map capabilities and is wonderful with its iCloud syncing ability.
I have purchased this app a long time ago and had since figured its development support was over. However this new update has added all the best features and support for iOS 10. I would definitely have paid for it all over again.
This was by far the most useful Holiday app I have on my phone and running an online sales business this has been essential for me.
Don't settle for anything less. This is the best package tracker on the App Store.
Glad I got it 💜📦🌈📬
This app is very handy. I can view all of my tracking in one place and it will even show where it is on a map.
I have it on my iPhone, iPad and Mac which I got on the Mac App Store.
I like that it sends me notifications if I enable that and can also have it added to my calendar when it will arrive if I choose to enable that in settings.
When the package is delivered it shows up with a nice check mark. I really like this app and am glad I got it. I also got the mac app of deliveries.
I got this app for the iPhone and works great on the iPad. I only needed to buy this once and works on both my iPhone and iPad 😎
I chose to sync with JuneCloud and it works great 🌈
- $4.99
- Category: Utilities
- Updated: Dec 22, 2016
- Version: 8.0.1
- Size: 28.7 MB
- Apple Watch: Yes
- Languages: English, Danish, Dutch, French, German, Italian, Japanese, Norwegian Bokmål, Swedish
- Seller: Junecloud LLC
- © 2008–2016 Junecloud LLC
Compatibility: Requires iOS 10.0 or later. Compatible with iPhone, iPad, and iPod touch.


text: TabsArticle Panel on Animal Health and Welfare EFSA Journal: EFSA Journal 2011;9(1):1966 [125 pp.]. doi: 10.2903/j.efsa.2011.1966 Panel Members: Anette Bøtner, Donald Broom, Marcus Doherr, Mariano Domingo, Joerg Hartung, Linda Keeling, Frank Koenen, Simon More, David Morton, Pascal Oltenacu, Albert Osterhaus, Fulvio Salati, Mo Salman, Moez Sanaa, Michael Sharp, Jan Stegeman, Endre Szücs, Hans-Hermann Thulke, Philippe Vannier, John Webster, Martin Wierup Acknowledgements: The Panel wishes to thank the members of the Working Group on the Welfare of Animals during Transport: Donald Broom, Silvana Diverio, Joerg Hartung, Johann Hofherr, Toby Knowles, Bert Lambooij, Malcolm Mitchell, Leonardo Nanni Costa, Moez Sanaa, Endre Szűcs, Antonio Velarde, Eberhard Von Borrell, John Webster and Martin Wierup and EFSA staff: Oriol Ribó for the support provided to this scientific opinion. The participants at the Stakeholder Technical Meeting held at EFSA-Parma on 13 October 2010 are gratefully acknowledged for the useful discussions during the meeting and the information provided. Contact: firstname.lastname@example.com Type: Opinion of the Scientific Committee/Scientific Panel On request from: European Commission Question Number: EFSA-Q-2010-00053 Adopted: 2 December 2010 Published in the EFSA Journal: 12 January 2011 Last Updated: 19 January 2011. This version replaces the previous one/s. Affiliation: European Food Safety Authority (EFSA), Parma, Italy Send Print Note: Read the article on the Wiley Online Library Abstract: The Scientific Opinion on the welfare of animals during transport reviewed the most recent scientific information concerning the main farm species. New scientific evidence and consequent conclusions and recommendations were arranged following the structure of Annex I of EC Regulation 1/2005 . On fitness for transport, recommendations for cattle and poultry were focused on repeated humane handling and careful inspection prior to transport. On the means of transport, use of partitions in horse transport, compulsory fasting of pigs with provision of water at stops, and temperature limits for poultry were major recommendations. Maintaining stability of animal groups was recommended as good practice, with special emphasis on the need to avoid mixing unfamiliar pigs or goats. On watering and feeding intervals, journey times and resting periods, journey duration should not exceed 12 hours for horses and 29 hours for cattle. Horses should be supplied with water one hour before and one hour after transport, and for cattle there should be a 24 hour recovery period with access to food and water. For rabbits, time spent inside the containers during lairage should be considered journey time. Space allowance for horses should be given in terms of kg/m2 instead of m2/animal. For cattle and sheep, it is recommended that space allowances should be calculated according to an allometric equation relating size to body weight. Limits for stocking densities of broilers in containers should be related to thermal conditions. On the navigation systems, temperature monitoring systems should be incorporated. Minimum standards should be established regarding data type to be recorded, the system and the on-board architecture. Recommendations for further research focused on the thermal limits and regulation for poultry and rabbits, the effects of ventilation on pigs, space allowance for rabbits, newly hatched chicks and pigs, optimal journey times for horses, pigs and calves. © European Food Safety Authority, 2011 Keywords: Animal welfare, fitness for transport, means of transport, transport practices, watering and feeding, journey times, space allowances Print on demand Number of Pages: 125