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Job displacement (involuntary job loss due to firm closure or downsizing) affects many workers over their lifetime. Displaced workers may face long periods of unemployment and, even when they find new jobs, tend to be paid less and have fewer benefits than in their prior jobs. Helping them get back into good jobs quickly should be a key goal of labour market policy. This report is the fourth in a series of reports looking at how this challenge is being tackled in a number of OECD countries. It shows that many displaced workers get new jobs relatively quickly in Australia, mostly thanks to a flexible and dynamic labour market. A small minority of displaced workers receive special support via the labour adjustment programmes, but some displaced workers who would need specific assistance, in particular in the older worker and/or low-educated groups, do not get sufficient support or only too late. There is room to improve policies by moving away from the current sectoral approach to special assistance programmes for workers collectively dismissed, towards an approach covering all sectors of the economy, with the intensity of intervention tailored to the circumstances and needs of the displaced workers. Expanding the training component for displaced workers and making use of skills assessment and training to better target the training and enhance its effectiveness would also help displaced workers transition to sustainable jobs of a certain quality.
Latvia has undergone major economic and social change since the early 1990s. Despite an exceptionally deep recession following the global financial crisis, impressive economic growth over the past two decades has narrowed income and productivity gaps relative to comparator countries in the OECD. But Latvians report low degrees of life satisfaction, very large numbers of Latvians have left the country, and growth has not been inclusive. A volatile economy and very large income disparities create pressing needs for more effective social and labour-market policies. The government's reform programme rightly acknowledges inequality as a key challenge. However, without sustained policy efforts and adequate resources, there is a risk that productivity and income growth could remain below potential and social cohesion could be further weakened by high or rising inequality.
Today the OECD is launching a new project with JP Morgan and Chase Foundation to measure and analyse skills needs in a harmonized way across countries. Experts from various countries and fields of discipline are meeting at the OECD to discuss methodological issues involved in developing a cross-country indicator of skill needs. By informing policy, this new data tool will make strides towards addressing skill shortages.
English, PDF, 192kb
The Organisation for Economic Cooperation and Development (OECD) and J.P. Morgan through its Foundation today launched a new project "Adapting to Changing Skills Needs" to fill knowledge gaps in the assessment of skill mismatches and to identify international best practice in addressing them.
A discussion on how can we reconcile the apparently contradicting views of labour market demand for soft skills versus technical job-specific skills.
Openness to change and a continuous questioning of the way we work are the keys to being prepared for the Future of Work. This advice comes from Mark Keese, Head of the Employment Analysis and Policy Division at the OECD, and we catch up with Mark following the OECD's Future of Work Forum in January 2016.
Discussion on how technology helps measuring skills shortages in real time
Regional disparities in the supply and demand of skills do exists in many OECD countries. Local level actors need to be equipped with the right tools and capacities to develop innovative employment and job creation strategies tailored to their local conditions.
Average wages can vary markedly between socio-economic groups (gender, native- and foreign-born; high-skilled and low-skilled parents; workers of different ethnicities; age). These differences between groups of workers contribute to high overall wage inequality.
Latvia faces a huge demographic challenge. Since restoration of its independence in 1991, the country lost more than a quarter of its resident population.The report "Investing in Youth: Latvia" states that investing in youth, by upgrading skills and promoting employment, is a priority if Latvia wants to offer its young people a positive outlook and address the demographic challenge.


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- 1/4 cup all-purpose flour
- 1 1/2 teaspoons Essence
- 1 1/2 pounds catfish fillets
- 1/2 cup plus 2 tablespoons vegetable oil
- 1 cup chopped yellow bell pepper
- 2 teaspoons minced garlic
- 2 to 3 tablespoons Red Curry Paste, or to taste
- 2 tablespoons soy sauce
- 2 cups shrimp or chicken stock
- 1 cup canned, drained bamboo shoot strips
- Salt
- 1/2 cup julienned fresh Thai basil, if unavailable use Italian basil
- Steamed Jasmine Rice
Preheat oven to 200 degrees F.
In a shallow bowl, combine the flour and 1/2 teaspoon Essence. Season the fish on both sides with the remaining teaspoon Essence.
In a large, heavy skillet, heat 1/2 cup of the vegetable oil to 360 degrees F.
Dredge 2 of the fillets in the flour, coating evenly and shake to remove excess flour. Fry the fillets until golden brown, about 4 minutes on each side. Remove with a slotted spatula and drain on paper towels. Repeat with the remaining fish.
Keep the fish warm in the oven while preparing the curry.
To prepare the curry heat the remaining 2 tablespoons oil in a wok over medium-high heat. Add the bell peppers and cook, stirring, until soft, 2 to 3 minutes. Add the garlic and cook for 30 seconds. Add the curry paste and soy sauce and stir to combine. Add the stock and bring to a boil. Lower the heat to a simmer and cook for another 5 minutes. Add the bamboo shoots and stir to combine. Add the fried fish and cook until fish is heated through, about 1 minute. Season, to taste, with salt. Remove from the heat. Stir in the basil and serve with jasmine rice.
Recipe Details
- Source: Emeril Live EM1G16e
- Dish Type: Entree
- Cuisine: Asian
- Cooking Method: Combination
- Effort Level: Moderate
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subset: commoncrawl


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This piece may be shown differently in our showroom than as pictured on website.
Select items have different fabric choices available, price may vary depending on fabric chosen.
Pricing is "as displayed" in our showroom. Please contact us for more
information on this piece.
When you're trying to keep your room design simple and sleek, extra seating can start to make your room feel a little crowded. This accent ottoman is a great way to add extra seating while keeping the sight lines open, making sure the room maintains its spacious feel. Use the ottoman alone or double it for a perfectly matched set. The ottoman is easy to move around when its needed, as it comes equipped with swivel casters hidden under the base.
The LAUREL CANYON Wheatley Accent Ottoman with Nailhead Detailing by Lexington at Becker Furniture World in the Twin Cities, Minneapolis, St. Paul, Minnesota area. Product availability may vary. Contact us for the most current availability on this product.
Less is more. Fewer pieces can make a bigger impact if they are carefully chosen and meticulously designed. Impeccable contemporary forms with a soft and pleasing touch are the hallmark of the Laurel Canyon collection. Bringing together timeless, architecturally-inspired shapes and statement pieces with a stunning blend of materials, Laurel Canyon provides dreamy furnishings for homes everywhere. The look of Laurel Canyon starts with sleek, contemporary furniture crafted from Cathedral Cherry, but is enriched with surprising detail in the form of silver travertine tops, hand-burnished silver leaf, and sculptural modern hardware. Two sizes of dining table are available to bring Laurel Canyon's soft, contemporary look to both formal dining rooms and the flexible arrangements of open plan homes. Distinctive upholstered pieces in a spacious scale turn your living room into a luxe lounge cushioned by blended down seat cushions. For those who arrange their decor with the eye of a perfectionist, for those who know what they like but can't always find it - your search is finally over, thanks to Laurel Canyon.
The LAUREL CANYON collection is a great option if you are looking for Transitional
Contemporary furniture in the Twin Cities, Minneapolis, St. Paul, Minnesota area.
These images are representative of this group as a whole and may differ from this item.
Browse other items in the LAUREL CANYON collection from Becker Furniture World in the Twin Cities, Minneapolis, St. Paul, Minnesota area.
This item has been tagged as: Ottomans, Storage Ottoman, Chairs and Ottomans, Ottoman with Chair, Coffee Ottoman, Cocktail Ottoman, Ottoman Coffee Table, Ottoman Cocktail Table, Table Ottoman, Large Ottoman, Glider with ottoman, Rocker with Ottoman, Recliner with Ottoman, Stool, Footstool, Tuffet, Hassock, Pouf
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The Hottest NYC Bar Openings, Fall Edition
To date 2013 has seen a slew of exciting bar openings that can wet your whistle in creative ways. Once you're done perusing our list of the year's hottest restaurants, click through the slide show below to see the hottest spots to grab a tipple. From some all-weather rooftop bars to a couple appealing options in super-hot Greenpoint, you'll be sure to find someone who will fill your glass.


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Parmesan French Bread
|French bread loaf
|1 Cup (16 tbs), melted (1/2 Block)
|Chopped onion
|1⁄4 Cup (4 tbs) (Round)
|1 Cup (16 tbs)
|Worcestershire sauce
|1 Dash
Split French bread almost completely through lengthwise.
Coat two halves with melted butter.
Slice each half loaf almost completely through so you can easily tear off the slices.
Coat each slice with mixture of chopped onion, mayonnaise and Worcestershire sauce.
Sprinkle 1 medium can of Parmesan cheese heavily over top of mayonnaise mixture.
Place on cookie sheet and bake in 350° oven for 15 minutes or until light and bubbly.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 1001 Calories from Fat 810
% Daily Value*
Total Fat 91 g139.8%
Saturated Fat 33.5 g167.5%
Trans Fat 0 g
Cholesterol 160.2 mg53.4%
Sodium 544 mg22.7%
Total Carbohydrates 43 g14.2%
Dietary Fiber 2.8 g11.4%
Sugars 0.5 g
Protein 9 g17.2%
Vitamin A 28.1% Vitamin C 1.3%
Calcium 4.3% Iron 15.1%
*Based on a 2000 Calorie diet


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Helicopters were originally invented by a child prodigy, who only wanted a remote-controlled toy to pass notes at camp. Get a broader view of clandestine activities with this Groupon.
Choose Between Two Options
- $199 for a twilight helicopter tour for two with champagne (a $438 value)
- $599 for a private party for up to 10 with a helicopter ride (a $1,300 value)
A twilight tour provides romantic suspensions over the glittering expanse of Los Angeles. Before lifting off for the 20- to 25-minute ride, each passenger takes his or her place at a window seat for unobstructed observation of many of the city's famous landmarks, including the Hollywood sign, Mann's Chinese Theater, and Walt Disney Animation Studios. While bubbly champagne tickles tongues and eyeballs feast on the city lights, an MP3 stereo headset with two-way communication allows pairs to whisper "I love you" or call out state license plates spied on speeding cars below.
Located in an airport hangar, two-hour private parties are led by a coordinator and an assistant. After a pilot discusses flight safety and gives guests a tour of the helicopter, he takes 10 people on an five- to seven-minute flight.
Adventure Helicopter Tours
Adventure Helicopter Tours parades sightseers about the skies above Los Angeles for aerial appreciation of the city's many landmarks. The outfit hosts 12 separate tours around southern California, including those that fly over the homes of celebrities, providing ample opportunities to pass judgment on their backyard barbecuing skills. Other options include a romantic sunset excursion, and a route that flies past the Hollywood sign. Every passenger on an Adventure Helicopter Tours excursion enjoys window seating and a two-way MP3 stereo headset for easy communication with fellow sightseers.
Customer Reviews
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+18188967900Get Directions


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Greetings Guest!!Dismiss Notice
In order to combat SPAM on the forums, all users are required to have a minimum of 2 posts before they can submit links in any post or thread.
[NEWS] EA Store opens tonight!
Discussion in 'EA Land/The Sims Online Stratics Forums' started by [email protected], Jul 14, 2008.


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"A classicly elegant hotel where peace and relaxation reign, set in a stunning private cove near Ocho Rios"
There are 4 Wings (West Wing, Main Wing, East Wing and Beach Wing), plus 8 private cottages, with steps to the sea or beach. Décor throughout is calming. In the suites there's more a traditional colonial design, while the cottages are more modern. But whichever you opt for, expect a mixture of white walls with historic prints, blue striped cushions, hand-carved four-posters, hard-wood floors, plantation shutters, and balconies akin to living rooms with oversized sofas and writing desks. Most importantly, each room has a glorious sea view.
The cheapest (still lovely) are the Balcony Suites set on the upper floor, next up are the Deluxe Veranda Suites which have larger living-room style verandas. We loved our Premier Veranda Suite in the West Wing, which had the biggest terrace we saw anywhere in Jamaica, and overlooked the gently lapping sea.
Top choice is the White Suite - a luxurious, very private suite with its own pool, garden and direct sea access. The Cowdray Suite is lovely too, set upstairs on the East Wing with superb views, plus a dressing room and an extra-large veranda.
Romantics will enjoy the 1-bedroom Cottages set on the beachfront or overlooking the sea, but if you want real privacy, go for one of the 2-bedroom Cottages. Each has a private entrance, a mixture of Jamaican and Indonesian style and great sea views. With the exception of Cottage 6 and Blue Cottage, they all have private infinity or plunge pools. To really treat yourself, opt for the ultra-modern Cottage 7, which has access to its own private cove; we thought this would make an exceptional honeymoon hideaway.
A la carte meals are served in either the Seaside Restaurant (breakfast and lunch) or Garden Restaurant (dinner), and are generally very good. The atmosphere in both is buzzy and the food delicious. If you'd prefer, you can book a meal-plan - either half or full board.
Breakfast overlooking an aquamarine sea is a treat. We loved the authentic Jamaican breakfast, which changes on a daily basis and includes steamed callaloo, ackee and salt fish, or spicy escoveitch fish. The crusts are cut off your toast, which we felt was a little OTT, but the service was excellent.
Enjoy a complimentary cocktail between 11.30am and 12.30pm, to whet your appetite for a restaurant lunch (we loved the guacamole shrimp cocktail and calamari rings).
Afternoon tea and pre-dinner hors d'oeuvres will keep any hunger pangs at bay, and after enjoying the marvellous sunset from the cocktail terrace, head to Teddy's Beach Bar for the eponymous barman's renditions of popular tunes as well as his excellent mixologist skills.
Dinner is an extensive menu that may include coriander snapper with chilli ginger sauce or poached papaya in lime and cinnamon syrup. There is usually a live band playing, but if you'd prefer, room service can be ordered and your meal served course-by-course.
Babies and young children are not allowed, however children aged 10 and over are allowed at certain times of year (March 1st - December 14th). Children aged 12 and over are allowed year round.
Teens (over 12)
For more family-friendly places, see our Kids Collection


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UPS Tests Package-Delivering Drone
UPS has successfully tested a car-based drone, the parcel service says. The Workhorse Group Horsefly UAV (unmanned aerial vehicle) Delivery system can launch from a UPS truck to autonomously deliver a package to a home as the driver continues on route to make another delivery and return to the truck. This test was conducted in…


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A Short Guide To The Warner Lieberman Climate Security Act
By Rob Safuto on May 31, 2008 in Analysis
There's going to be a lot of talk about cap-and-trade next week as the Warner-Lieberman Climate Security Act (S.3036) opens for discussion on the floor of the United States Senate. If don't already know the basics then the following information can help you to understand what it's all about.
The purpose of the Act is stated within as follows:
(1) to establish the core of a Federal program that will reduce United States greenhouse gas emissions substantially enough between 2007 and 2050 to avert the catastrophic impacts of global climate change; and
(2) to accomplish that purpose while preserving robust growth in the United States economy, creating new jobs, and avoiding the imposition of hardship on United States citizens.
In short, the bill aims to reduce harmful emissions between 2012 and 2050 without destroying the U.S. economy.
The purpose will be achieved by creating caps on emissions from certain 'covered' facilities. For the most part the caps will apply to any coal, natural gas or oil fired power plant. The caps will also apply to companies that operate large vehicle fleets.
The caps will be acknowledged via emissions allowances that will be doled out to a variety of parties. Companies that own 'covered' facilities will have the right to emit greenhouse gases up to the limit of their allowances. If a company exceeds their limit they can buy allowances from other parties or pay heavy penalties for exceeding the cap.
Emissions allowances are tradeable and bankable. Allowance holders can sell them to just about anyone they like. Allowance holders can also bank unused allowances for use in future years.
Companies who emit greenhouse gases will initially be allocated enough allowances to cover their emissions but as years go by they will be issued fewer allowances.
Affected Parties
Companies that own fossil fuel powered electric generation facilities will be subject to caps and thus receive allowances. The vehicle fleet clause will likely affect companies like UPS, Federal Express and large over the road trucking companies as well.
Because emissions allowances are tradeable, it is likely that emissions traders will buy and sell allowances as well. These traders will likely consist of established commodity trading houses as well as emissions trading start-ups that arise as a result of this legislation.
State governments, Electric and Natural Gas load serving entities (LSEs) will receive allowances as well. These parties are directed to sell the allowances and use the money for a variety of purposes. The most popular revenue spending requirements are aimed at mitigating impacts on low-income energy consumers and promoting energy efficiency.
New Government Entities
This bill creates the Climate Change Credit Corporation. The CCCC will administer the cap-and-trade program. They will be responsible for doling out emissions allowances and allocating revenue to a wide variety to companies and programs.
The Carbon Market Efficiency Board is also established. The CMEB will be responsible for assessing the economic impact of the program as well as maintaining the market for emissions allowances.
New Government Programs
The Federal Greenhouse Gas Registry will be created to track emissions of greenhouse gases. Entities that emit greenhouse gases will be required to submit data to this registry. The Domestic Offset Program will be responsible chiefly for distributing allowances to companies that produce verifiable, permanent reductions in greenhouse gas emissions. This will allow organizations to meet some of their emissions requirements by purchasing offset allowances which they can then submit to meet cap requirements. The Deficit Reduction Fund will be created to bank allowances that are not otherwise allocated. This fund increases yearly as fewer allowances are distributed.
The Program For Tribal Communities will deliver assistance to tribal communities affected by climate change. The Climate Change Worker Training Program will be established to create jobs in fields related to renewable energy. A Science Advisory Board will be established.
The International Climate Change Adaptation and National Security Program will be established. This program will be responsible for the submission of annual reports to the President and other government agencies
A number of funds are created by this bill including: The Energy Assistance Fund, The Climate Change Worker Training Fund,The Adaptation Fund, The Climate Change and National Security Fund, The Bureau of Land Management Emergency Firefighting Fund, The Forest Service Emergency Firefighting Fund, The Climate Security Act Management Fund and The Energy Independence Acceleration Fund.
How It All Works
Creation of emissions allowances effectively puts a price on greenhouse gas emissions. Emitters will then have to pay for their emissions starting with nothing at first and then more in the future as they are allocated fewer and fewer allowances. As such, emitting greenhouse gases will get more and more expensive. This will create incentives for emitters to invest in low carbon and carbon free technologies that will ultimately help in reducing all greenhouse gas emissions in the United States.
Meanwhile the federal government will be collecting revenues via the auctioning of allocated allowances and the sale of allowances that the government allocates to themselves. The resulting revenue is used to monetize the programs, funds and agencies mentioned in the paragraph above. Ostensibly these programs, funds and agencies will serve to accelerate the development of low-carbon and carbon free technologies as well as mitigating the impact of these changes on low-income consumers of energy.
The Projected Effects
The Energy Information Administration has written an extensive impact assessment of S.3036 which I recently reviewed. The short answers are these. The emission of GHG will be significantly reduced during the time period of this bill. Most of this reduction will be due to changes in the electric power sector. It is likely that Natural Gas will become an increasingly dominant fuel source for electric generation. Coal consumption is greatly reduced. Energy prices and this energy bills for consumers will be greatly increased. The impact of increased energy prices will affect the overall economy by reducing purchasing power and lowering demand for goods and services. Industrial activity is significantly effected by the changes. Significant revenue (between $300 and $800 Billion) is generated by Federal and State Governments auction and sale of emissions allowances.
The actual effects of S.3036 depend on a lot of factors. The ability of the U.S. to develop and deploy nuclear and carbon capture and sequestration (CCS) technologies is a very important one. If the U.S. is not able to develop these technologies then the increased reliance on natural gas will be pronounced. This would likely lead to significantly higher natural gas prices which would cause a greater negative impact on the overall economy.
The Road Ahead
This is a wide ranging and controversial piece of legislation. S.3036 essentially changes the landscape with respect to the economics of energy production and consumption for the next forty years. The Act also greatly increases the size and funding of the U.S. government as a result of the agencies, programs and funds contained in the Act.
Some will see this as an onerous increase in the power and responsibility of the government. While others will view S.3036 as landmark legislation that will change the planet for the better. Some see S.3036 as a vehicle for massive wealth redistribution. While others will call it a necessary sacrifice during a time of dire need for reductions in emissions. As such, expect intense debate and discussion that will likely end up passing the issue to the next Presidential administration.
It is also worth noting that the Warner-Lieberman legislation is not the only game in town. Recently Representative Edward Markey from Massachusetts announced a bill with stricter emissions requirements than S.3036. Perhaps the two pieces of legislation will give rise to a third bill that blends provisions included in each of them.


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Connecticut Will Play on the Red Rink, Which Seats 1,200
BY: Savanna Arral, NWHL
Northford, CT — The National Women's Hockey League (NWHL) today announced that the Connecticut Whale will call the Northford Ice Pavilion (NIP) home for the 2016-17 season.
"We are extremely excited that our facility will be home to our first professional hockey team," said NIP General Manager Bill Maniscalco. "What makes it even more special is that it is a women's professional team! I feel this will help grow the girls' hockey game in this area, both at a younger and older level."
NIP is an ice skating complex with several NHL-sized sheets, including the Red Rink, the former home of the Quinnipiac Bobcats, which seats 1,200 spectators. Last season, the Whale played at Chelsea Piers Connecticut in Stamford.
"The Whale is extremely excited to call the Northford Ice Pavilion our new home," said Connecticut General Manager Lisa Giovanelli. "The owners and staff of the facility are great women's hockey supporters and we're fortunate to build a relationship with them for our second season in the NWHL."
About the National Women's Hockey League (NWHL)
The NWHL is the first professional women's hockey league in North America to pay its players. The inaugural season began October 11, 2015 with the Founding Four: Boston Pride, Buffalo Beauts, Connecticut Whale and New York Riveters. The Boston Pride became the first team in NWHL history to raise the Isobel Cup on March 12, 2016.


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Webinar from the Mountain West Digital Library
Sandra McIntyre, MWDL Director
Rebekah Cummings, MWDL Assistant Director/Outreach Librarian
The Mountain West Digital Library (MWDL) provides a central search portal to over 800,000 digital resources from memory institutions in Utah, Nevada, Idaho, Arizona, and Hawaii. As a program of the Utah Academic Library Consortium for the last twelve years, MWDL brings together 122 partners, including academic libraries, public libraries, archives, museums, historical societies, and government agencies, to share expertise and resources for digitization, hosting, and aggregated search. As one of the first six Service Hubs to the Digital Public Library of America, MWDL provides the on-ramp for DPLA participation to memory institutions in the Mountain West.
Sandra and Rebekah will talk about how MWDL became a Service Hub for the DPLA and what being a Service Hub entails. They will also discuss upcoming MWDL/DPLA announcements and events such as the digitization mini-contracts program and the DPLA Community Representatives program.
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It would appear that both thanks and congratulations are in order throughout Hollywood on Tuesday (Dec. 14) following the early morning announcement of the 2011 Golden Globe nominees.
Alec Baldwin is up (deservedly, yet again) for his leading role on NBC's "30 Rock," and the show itself has been nominated for Best Television Series — Comedy or Musical.
In a press release from NBC Universal, Baldwin says "'30 Rock' is back, bigger and better than ever! We are very grateful to the Hollywood Foreign Press."
The show's executive producer, Robert Carlock jokes, "It is truly an honor to be nominated. We couldn't be more thrilled. Our table will require two vegetarian means. Is now the time to deal with this?"
First time nominee Chris Colfer of "Glee" took to his Twitter account shortly after the announcement to express his excitement.
"OMGG! I can't believe it! Am I awake? OUCH! Yes, I'm awake! I'm going to obnoxiously tackle everyone I see today!"
Fellow "Glee" star and Globes nominee Lea Michele chimes in, "Oh my g-d!!!! So excited, happy, thrilled, and thankful this morning 🙂 What amazing news!! So happy for our show, Jane, matt & chris too!!!!"
Christopher Gorham may not be nominated, but he made sure to send congratulations to pals Piper Perabo of "Covert Affairs" and Peter Gallagher of "Burlesque."
"Piper was nominated for a Golden Globe!!!!!!! #ThingsThatRule," the actor tweeted of his co-star's nomination. He followed up shortly after with, "Congrats are also due to @petergallagher_ for the Golden Globe nom of Burlesque!! Woo hoo!!"
Gallagher responded in kind with a "Thanks, Chris! I had no idea! Cheers for Piper!" tweet.
Jesse Tyler Ferguson was also in a congratulatory mood, tweeting his well wishes for his "Modern Family" co-stars Eric Stonestreet and Sofia Vergara.
"Yay for @ericstonestreet and @SofiaVergara who were nominated for Golden Globes! That's one hot couple. She better keep her hands off my man," he joked on Twitter.
Always hilarious, Stonestreet almost shares the love with his castmates. "Honored and grateful. We ARE an ensemble over there. ANY1 of us deserves 2 b nominated," he tweets.
Continuing, "But IN YOUR FACE @STARRINGRICO AND @NOLAN_GOULD!" referring to his pint-sized co-stars.
As for Michael Douglas, his best supporting actor nomination comes as a happy distraction for the cancer stricken legend.
He tells The Hollywood Reporter, "To be selected with these extraordinary nominees is an honor and boy was I ready for some good news!"
Best actress in a TV comedy or musical nominee Edie Falco had this to say following her nomination, "My friends and I at 'Nurse Jackie' are thrilled to be recognized for the work we love to do."
In another NBC press release, Dr. House aka Hugh Laurie says he is "thrilled and honoured" to be nominated. He continues, "I am now going to turn the house upside down looking for that other cufflink."
We hope Hugh finds it in time for the Jan. 16 show.


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Wear it as a base layer or wear it casually – the comfort of 45NRTH's 100% merino tee is second to none. Made with ultra soft 150 gram jersey knit wool, it efficiently wicks moisture, regulates temperature, and stretches for unrestricted movement while riding. The active cut and crew neck fits well under middle layers, while not being too athletic-looking for hanging out with friends after a long day of fatbiking. Its resistance to odor also means you won't scare your friends away.
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|28th June 2012 00:03
Regular User
There are a few people who do use the chat room. It's not official so if you want to help make it so, then go to the "Suggestions" area and look for the "Chat Room" thread. Also if you have any questions or concerns about the chat, post it there as well. You can also click on the link in my signature to get to the thread.
With that said,
I made this thread so that those who are online and IN the chat room can post here to let others know. That way we can get others involved. The only responses that should be here are ones to invite others while you yourself is in the chat room.
If there are any other messages here than it will make people uninterested in checking in on the thread whenever updated.
Right now [June 27, 2012] Bashfulcheeta and I are at the chat room. Whoever else is on should come join!
Last edited: 28th June 2012 22:59 by Salynn
PLEASE COMMENT HERE to support the chat room idea!
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|28th June 2012 14:32
Regular User
Just gotta say, I love this idea!
I'm in the chat room now, but I won't be for long, so if anyone is stopping by, do it quick!
Also, there's the option to get an email when someone posts in the chat room after you leave, so that's always an option too!
|4th July 2012 01:15
Regular User
Tis July 3rd [Pacific U.S. time] and as of right now, Zach and I are at the chat. Come join us if you're on and not doing anything important!
The link is in the first post :]
PLEASE COMMENT HERE to support the chat room idea!
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|7th July 2012 09:22
Regular User
I can tell only a few people are on right now but,
Right now [July 7th], Uni is at the chat.
I'll be leaving so go keep her company :D!
PLEASE COMMENT HERE to support the chat room idea!
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|8th July 2012 01:15
Regular User
|I'd love to join but I wont be on the chat for a while. My sister and her frend broke the laptop, and my phone doesn't have the needed plugins for the chatroom to work ):
|8th July 2012 01:22
Regular User
Your sister and her friend needs to be [b] slapped.
Last edited: 12th July 2012 03:17 by Salynn
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|8th July 2012 01:26
Regular User
|I agree.
|11th July 2016 13:24
Regular User
In many ways, a woman's hair style mirrors her personality and plays a large role in the first impression she makes when others meet her. Is her style demur and shy, sexy with curls and wispy bangs, or a short, boyish cut that signals to the outside world that she enjoys the outdoors and sports? Read the article to find out. www.fashoinstyle.us
Most businesses think that business funding is something that you need when your business is short on cash or times are hard. A lot of businesses go out looking for business funding when the business is not good. The time to get business funding is not when your business is doing horrible or you are strapped for cash. www.businessmom.us
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Organizing a party is easy when you have the right shop to get the supplies you need. The best you can do to have an easy time with your party planning is to start with the preparations early. It will save you from last minute rushes that could ruin a good party. www.shoppingadvice.us
You want to sell your home. Whether you are selling your home yourself, or you are going to use a real estate agent, you must price it before you advertise it for sale. Sellers have misconceptions about the value of their home and make one or more of these five common mistakes when determining a price. www.housedecor.us
Adventure travel agents make any travel possible and help you to enjoy your travel even more. Traveling is a way of exploring and experiencing what a particular place can offer, and all the things that can be really adventurous. However, travel will not be successful without adventure travel agents. www.luxurytour.us
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Are you searching for a good online law school? Before you register for an online law course it will do you good to do some self assessment by asking some basic questions to you, so that your decision turns out to be the right one. The first question you have to answer is whether online education, be it law or any other course, is the right one for you. www.lawadvice.us
Today is the first day of spring. Whether you are still buried in snow, freezing temperatures and are expecting yet another snowstorm (as we are) or your daffodils are popping up and color is everywhere, it is time to review and update your spring wardrobe in anticipation of much warmer weather to come. www.shoppingblog.us
The Home Business industry is a multi-billion dollar industry, but unfortunately the vast majority of people (more than 95%) never achieve any level of success with it. Why? Because they don't know the 6 keys to home business success, and they give up before they see results. www.housedevelopment.us
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It's a fashionista's worst experience, even worse than looking oversize buddy, more degrading than wearing the same dress in another party -- it's the fear of symbolizing looking yesteryear fashion trend model. Sometimes, fashion trends is considered as fads, are disreputably erratic. www.fashionkeeper.us
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What's the secret of this johnny-come-lately's success, and do you prefer the moist, squidgy sort, or the light, fluffy variety?
Campaigners for real bread are attempting to revive the ancient harvest festival of Lammas, or loaf-mass
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So, the holiday's booked, bags are packed, the cat's being fed by the neighbours, and then it hits you - who's going to look after your artisanal sourdough culture? Help may be at hand ...
Of all the food crazes of recent years, are macarons worth the hype?
The healthiest thing about carrot cake is the name. But then that's probably why it's so darn popular
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Are cheese straws your favourite party snack – or do you prefer something a little less practical?
There are dozens of new books around to feed the current national obsession with baking, but which will put the icing on your efforts and which fail to rise to the challenge?
Which modern additions to hot cross buns do you approve of and what do you eat them with?
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Dan Lepard answers common cookie issues in his baking masterclass and invites you to add your questions into the mix
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And the award for the best baking tip in a leading role goes to ...
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Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption
DOI: 10.1186/ar4366
© Rasheed et al.; licensee BioMed Central Ltd. 2013
Received: 2 August 2013
Accepted: 18 October 2013
Published: 4 November 2013
The T allele of a single nucleotide polymorphism (SNP: rs2544390) in lipoprotein receptor-related protein 2 (LRP2) is associated with higher serum urate and risk of gout in Japanese individuals. SNP rs2544390 also interacts with alcohol consumption in determining hyperuricemia in this population. We investigated the association of rs2544390 with gout, and interaction with all types of alcohol consumption in European and New Zealand (NZ) Māori and Pacific subjects, and a Māori study cohort from the East Coast region of NZ's North Island.
Rs2544390 was genotyped by Taqman®. From NZ a total of 1205 controls and 1431 gout cases clinically ascertained were used. Publicly available genotype and serum urate data were utilized from the Atherosclerosis Risk in Communities (ARIC) study and the Framingham Heart Study (FHS). Alcohol consumption data were obtained by consumption frequency questions in all study cohorts. Multivariate adjusted logistic regression was done using STATA.
The T allele of rs2544390 was associated with increased risk of gout in the combined Māori and Pacific Island cohort (OR = 1.20, P = 0.009), and associated with gout in the European subjects, but with a protective effect (OR = 0.79, PUnadjusted = 0.02). Alcohol consumption was positively associated with risk of gout in Māori and Pacific subjects (0.2% increased risk/g/week, P = 0.004). There was a non-additive interaction between any alcohol intake and the risk of gout in the combined Māori and Pacific cohorts (PInteraction = 0.001), where any alcohol intake was associated with a 4.18-fold increased risk in the CC genotype group (P = 6.6x10-5), compared with a 1.14-fold increased risk in the CT/TT genotype group (P = 0.40). These effects were not observed in European subjects.
Association of the T-allele with gout risk in the Māori and Pacific subjects was consistent with this allele increasing serum urate in Japanese individuals. The non-additive interaction in the Māori and Pacific subjects showed that alcohol consumption over-rides any protective effect conferred by the CC genotype. Further exploration of the mechanism underlying this interaction should generate new understanding of the biological role of alcohol in gout, in addition to strengthening the evidence base for reduction of alcohol consumption in the management of gout.
Elevated serum urate in humans is the central risk factor for gout. To date genome-wide association scanning has identified 28 loci that explain approximately 6% of the variation in serum urate levels in European Caucasians [1]. Prominent associations are with renal (SLC2A9, SLC17A1, SLC22A11, SLC22A12, PDZK1) and gut (ABCG2) molecules directly involved in urate transport. Not unexpectedly some of these genes are also associated with gout [1–4]. In Japanese the T allele of single nucleotide polymorphism (SNP) rs2544390 in the LRP2 gene has been associated with elevated serum urate by genome-wide scanning [5] and is associated with gout in Japanese, conferring a moderate risk of odds ratio (OR) = 1.32 [6]. LRP2, also known as megalin, is a member of the lipoprotein receptor-related protein (LRP) family, with its predominant function in lipid metabolism through controlling the activity of lipoprotein lipase [7, 8]. LRP2 plays a role in the reabsorption and metabolism of renal glomerular-filtered substances, including albumin and low molecular weight proteins [9].
Along with inherited genetic variants, dietary factors, such as sugar-sweetened beverages and alcohol consumption influence serum urate levels and gout risk [10–13]. Beer and spirits (but not wine) intake is positively correlated with serum urate and the relative risk of gout increases with increasing alcohol (particularly beer) consumption in men [10, 14]. Recently, in a Japanese male sample set there was evidence for a LRP2-environment interaction, where there was a significantly increased risk conferred by the rs2544390 TT genotype for hyperuricemia with increased alcohol consumption [15].
This study aimed to test for an association of LRP2 rs2544390 with gout and serum urate in European Caucasian and Eastern and Western Polynesian ancestral groups of New Zealand. The interaction of alcohol consumption with genotype was also evaluated.
Study participants
The New Zealand subjects consisted of gout cases clinically ascertained by the American College of Rheumatology criteria [16]. The comparison group was self-reported in their lack of a diagnosis of gouty arthritis. Recruitment was during the period 2006 to 2012. All variables except for biochemical measurements and body mass index (BMI) were self-reported. Demographic and clinical data are reported in Additional file 1: Table S1. For initial genetic analysis subjects were divided into four ancestral groups [2]; European Caucasian (555 cases, 282 controls), Eastern Polynesian (EP; Cook Island and NZ Māori; 374 cases, 533 controls), Western Polynesian (WP; Samoa, Tonga, Niue, Tuvalu and Tokelau; 285 cases, 165 controls) and mixed Eastern and Western Polynesian (EP/WP; 21 cases, 18 controls). A separate Māori sample set from the rohe (area) of the Ngati Porou iwi (tribe) from the Tairawhiti region on the East Coast of the North Island of New Zealand was included, ascertained as described above (196 cases, 207 controls). This sample set was recruited in collaboration with Ngati Porou Hauora (health service) (NPH). The New Zealand Multi-Region Ethics Committee (MEC/105/10/130) granted ethical approval, with the Northern Y Region Health Research Ethics Committee granting ethical approval for the Ngati Porou Hauora study (NTY07/07/074). All participants gave fully informed written consent for taking part in the study.
Data from the Framingham Heart Study (FHS) (Generation 3 only) and Atherosclerosis Risk in Communities (ARIC) cohorts were also used for evaluating associations with serum urate in European Caucasians. The approval number was #834 for accessing data from the ARIC and FHS studies under the project name 'The Genetic Basis of Gout.' Subjects from the ARIC and FHS studies who self-reported as taking diuretic medication, who were first degree related and who were not of European Caucasian ancestry were excluded. The ARIC dataset consisted of 4,144 individuals and the FHS of 3,047 individuals.
Data collection
Serum urate levels were measured for NZ subjects by the uricase oxidation method, the end point determined by a Roche chemistry modular P/D analyzer. In all data sets, alcohol consumption was obtained by food frequency questionnaire. NZ participants were asked at recruitment how many servings of beer, spirits, wine and other alcohol were consumed in the previous week. For conversion of servings/week intake into g/week intake, values were multiplied by the estimated quantities of alcohol in each category of drink (beer = 10 g/300 ml serving; wine = 15 g/200 ml serving; spirits = 10 g/serving; other = 10 g/serving). For ARIC, alcohol data were supplied as g/day (from examination 1 in the years 1987 to 1989) usage and converted into g/week for this study. For FHS, alcohol intake data were obtained as number of servings per week (beer, wine and liquors) (from visit 1 for Generation 3 in the years 2002 to 2005) and converted into g/week alcohol as described above. Serum urate data were obtained from examination 1 for ARIC and visit 1 for FHS.
Sample preparation and genotyping
Separated white blood cells were used for DNA preparation by the guanidine hydrogen chloride method with chloroform extraction [17]. Taqman® genotyping for rs2544390 was performed using a Lightcycler® 480 Real-Time Polymerase Chain Reaction System (Roche Applied Science, Indianapolis, IN, USA) in 384 well plates. The FHS cohort had been genotyped by the Affymetrix SNP 5 platform and a custom designed gene-centric 50 K SNP platform and rs2544390 genotype was imputed using MACH1 v1.0.15 with the HapMap2 CEU sample set as reference haplotypes. In the ARIC sample set rs2544390 had been genotyped on the Affymetrix SNP 6 platform.
When comparing with the data of Hamajima et al. [15], it was important to be certain about allele assignments at rs2544390 - uncertainties can arise when allele prevalences are approximately 50% as is the case in the Japanese population. Our Taqman-generated genotypes were 100% concordant with genotype data generated by the Affymetrix Axiom genotyping platform in a subset of 66 NZ samples. Furthermore, the C allele is the major allele in European Caucasian [18], consistent with our Taqman genotype data. We confirmed consistency in allele assignment between our and the Hamajima et al. [15] data by genotyping using Taqman 15 samples (5 CC, 5 CT, 5 TT) from the Hamajima et al. study.
Statistical analysis
Regression analysis was used to investigate relationships between the variables in this study. For continuous response variables, this involved standard linear regression. For binary response variables (that is, discrete variables with only two levels), logistic regression was used. Both main effects and interaction terms were included in the models where appropriate. The adjusted OR for a single explanatory variable was obtained by using the logistic regression coefficient. An adjusted OR for the same variable was obtained by including additional variables in the logistic regression model, again taking the value of the model coefficient relating to the variable in question. Logistic regression analysis was used to assess the association between gout (binary response variable) and alcohol consumption and LRP2 genotype (explanatory variables), and linear regression analysis was used to assess the association between serum urate levels (response variable), and alcohol consumption and LRP2 genotype (explanatory variables). Unstandardized regression coefficients are reported. Main effects were included in the model for alcohol consumption and LRP2, and for the covariates age, sex, BMI and sugar-sweetened beverage consumption. Individuals with missing data from any variable were excluded from analysis. An interaction term between alcohol consumption (both as a continuous and a binary variable) and rs2544390 genotype (binary: those who had at least one T allele (T/C or T/T) and those with none (C/C)) was also included. All analysis was done using Intercooled STATA™ software version 8.0 (College Station, TX 77845, USA). Meta-analysis of allele counts was performed in R within STATA™ using rmeta [19] to calculate combined ORs and to evaluate heterogeneity between studies. Coefficients with P ≤0.05 were considered to indicate a nominally significant association between the response and explanatory variables.
Association analysis of rs2544390 with gout
Sample set
Case genotypes, number (frequency)
Control genotypes, number(frequency)
T frequency
T frequency
Allelic OR, (95% CI)
Allelic OR,(95% CI)
European Caucasian
426 (0.384)
249 (0.441)
0.79 (0.64-0.97)
0.73 (0.52-1.03)
Eastern Polynesian
456 (0.610)
621 (0.583)
1.11 (0.92-1.35)
1.09 (0.82-1.44)
Mixed Eastern Western Polynesian
27 (0.643)
6 (0.333)
21 (0.583)
1.25 (0.53-2.96)
9.15 (0.96-87.65)
Western Polynesian
405 (0.711)
216 (0.655)
1.30 (0.97-1.75)
1.21 (0.82-1.77)
Ngati Porou Hauora
249 (0.635)
68 (0.321)
237 (0.572)
1.30 (0.98-1.73)
1.25 (0.83-1.88)
Association of rs2544390 and serum urate (mmol/L)
Ancestral group
Unadjusted β-coeff(95% CI)
Adjusted β-coeff (95% CI)
All European Caucasian non-gout
-0.00099 (-0.0029 to 0.0049)
-0.00029 (-0.0041 to 0.0035)
NZ Māori and Pacific Island non-gout
0.0068 (-0.0095 to 0.0232)
-0.0015 (-0.016 to 0.013)
Association of alcohol intake (g/week) with serum urate (mmol/L)
Study group
β (95% CI)
All European Caucasian non-gout
0.00007 (0.00004 to 0.00009)
NZ Māori and Pacific Island non-gout
0.00008 (0.00001 to 0.00014)
NZ European Caucasian gout
0.000007 (-0.00012 to 0.00013)
NZ Māori and Pacific Island gout
0.00007 (-0.00001 to 0.00015)
Association of alcohol intake with gout
Alcohol consumption as continuous variable (g/week)
Alcohol group
Unadjusted OR (95% CI)
Adjusted OR(95% CI)
All alcohol types
NZ European Caucasian
1.000 (0.999 to 1.002)
1.001 (0.999 to 1.004)
NZ Māori and Pacific Island
1.001 (0.999 to 1.002)
1.002 (1.001 to 1.003)
NZ European Caucasian
1.002 (0.999 to 1.004)
1.003 (1.000 to 1.006)
NZ Māori and Pacific Island
1.002 (1.001 to 1.003)
1.003 (1.001 to 1.004)
NZ European Caucasian
0.998 (0.996 to 1.000)
0.999 (0.996 to 1.001)
NZ Māori and Pacific Island
0.998 (0.994 to 1.002)
1.000 (0.996 to 1.005)
NZ European Caucasian
1.002 (0.999 to 1.006)
1.005 (1.000 to 1.011)
NZ Māori and Pacific Island
0.999 (0.997 to 1.001)
1.001 (0.998 to 1.005)
Alcohol consumption as dichotomized variable (No alcohol versus any alcohol intake)
All alcohol types
NZ European Caucasian
0.79 (0.54 to 1.15)
0.96 (0.56 to 1.62)
NZ Māori and Pacific Island
0.98 (0.80 to 1.19)
1.36 (1.03 to 1.79)
NZ European Caucasian
1.26 (0.93 to 1.69)
1.32 (0.88 to 1.98)
NZ Māori and Pacific Island
1.55 (1.26 to 1.90)
2.4 x 10-5
1.37 (1.03 to 1.81)
NZ European Caucasian
0.60 (0.45 to 0.81)
0.66 (0.46 to 0.95)
NZ Māori and Pacific Island
0.66 (0.48 to 0.90)
1.44 (0.93 to 2.23)
NZ European Caucasian
1.22 (0.86 to 1.75)
1.59 (1.02 to 2.48)
NZ Māori and Pacific Island
0.70 (0.52 to 0.94)
1.30 (0.86 to 1.94)
Interaction terms between alcohol intake and rs2544390 genotype for gout risk
Alcohol consumption as continuous variable
NZ European Caucasian
0.996 (0.991 to 1.002)
NZ Māori and Pacific Island
0.992 (0.987 to 0.997)
Alcohol consumption as dichotomized variable (No alcohol (reference) versus any alcohol intake)
NZ European Caucasian
0.45 (0.15 to 1.34)
NZ Māori and Pacific Island
0.27 (0.13 to 0.57)
Alcohol intake and gout association results for groups stratified by rs2544390 genotype
Study group
No alcohol
Any alcohol intake
NZ European Caucasian
1.57 (0.68 to 3.63)
1.45 (0.58 to 3.61)
1.02 (0.48 to 2.19)
NZ Māori and Pacific Island
4.18 (2.07 to 8.44)
6.61 x 10-5
2.68 (1.54 to 4.66)
4.83 x 10-4
3.01 (1.72 to 5.28)
1.13 x 10-4
Our study reports association of the T allele of LRP2 rs2544390 with gout risk in NZ Māori and Pacific Island samples (OR = 1.20, P = 0.009; Figure 1A). This observation is consistent with the reported association with increased serum urate and gout risk (OR = 1.32) of this allele in Japanese sample sets [5, 6], supporting the conclusion that LRP2 rs2544390 is a genuine risk factor for increased serum urate and gout in South East Asia and Oceania. In contrast, there was marginal evidence for association of rs2544390 with gout risk in European Caucasian, but in an opposing direction (OR = 0.79, PUnadjusted = 0.02). Heterogeneity (allelic and genetic) is also evident in gene associations with gout between among South East Asian, Polynesian and European Caucasian at SLC2A9 and ABCG2 (reviewed in [20]). If the association in European Caucasian were to be confirmed this would allow the inference that rs2544390 is not causal. It could also be inferred that haplotypic structure would substantially differ at this locus in the two ancestral groupings, aiding in fine-mapping the causal variant. With respect to the location of the putative causal variant, in European Caucasian rs2544390 is located (using 1,000 Genomes data) in a 40-kilobase haplotype block (SNPs with intermarker LD r2 >0.8) from 170.165 to 170.205 Mb on chromosome 2 wholly within LRP2; however, in Japanese the block is smaller at only 4-kilobases (170.201 to 170.205 Mb), spanning exons 84 and 85. This information would substantially reduce the amount of genome needing to be searched in fine-mapping the etiological variant.
There was a positive association between alcohol intake and serum urate in Māori and Pacific Island and European Caucasian control sample sets (Table 3) and between alcohol intake and risk of gout in Māori and Pacific Island only (Table 4). With respect to Māori and Pacific Island our data can be compared with that of Evans et al. [21] who observed that serum urate increases with reported alcohol intake in men of all ages of Polynesian ancestry. They also observed a higher prevalence of gout in people with high alcohol consumption. We confirm the relationship between alcohol intake, serum urate and risk of gout in people of Māori and Pacific Island ancestry, in a larger sample set and using contemporary statistical techniques that are able to adjust for potential measured confounders. As has previously been documented in European Caucasian [10], beer was more strongly associated with risk of gout than spirits in the Māori and Pacific Island samples, with no evidence for an association of wine consumption with risk of gout. In the NZ European Caucasian samples, the evidence for an association with risk of gout was strongest with beer and spirits consumption. However, in contrast to the Choi et al. study [10], we observed a protective relationship between wine consumption and risk of gout. Why this is the case is unclear, with confounding by other dietary behaviors a possible explanation. With respect to total alcohol consumption and gout risk in European Caucasian, the small NZ control sample size (n = 282) likely did not provide the power to detect a significant relationship. When alcohol intake was analyzed as a continuous variable, the direction and magnitude of the effect was similar in NZ European Caucasian to that in the Māori and Pacific Island sample set (Table 4).
There was evidence of non-additive interaction between rs2544390 genotype and alcohol consumption (Table 5; PInteraction = 0.001) in the combined Māori and Pacific Island sample set in determining the risk of gout. The interaction was manifest by the normally protective genotype (CC) at rs2544390 conferring a significantly elevated risk of gout in alcohol drinkers compared to non-drinkers (Table 6). If this interaction is proven robust by replication, understanding of the biological mechanism may generate new knowledge on the role of alcohol in the etiology of gout, with the current paradigm dictating that alcohol increases urate by generation of purines in the bloodstream (mostly by hepatic metabolism). Alcohol exposure appears to over-ride the protective effect of the CC genotype. However, this observation is not consistent with Hamajima et al. [15]. In this study, they observed association of the TT genotype with the highest risk of hyperuricemia in male subjects consuming ≥5 alcoholic drinks per week (OR = 3.30). We undertook a similar analysis in men in the combined Māori and Pacific Island non-gout sample set (Additional file 1: Table S5). In our analysis the CC genotype was associated with the highest risk of hyperuricemia in those drinking ≥100 g of alcohol per week (OR = 4.48). Also, using the Hamajima et al. [15] data, we produced a similar analysis in men to that in Table 6 (Additional file 1: Table S5). The CC genotype group in the NZ Māori and Pacific Island sample had the highest risk for gout with alcohol exposure (OR = 3.96) whereas the CC genotype group exhibited neutral risk for hyperuricemia in the Japanese sample set (OR = 0.99). Thus, while the Hamajima et al. and our results both report non-additive interaction between alcohol consumption and rs2544390 in hyperuricemia and gout, respectively, homozygosity for different alleles is associated with the highest risk upon exposure to alcohol. Given the consistency in rs2544390 association with serum urate and gout risk between Māori and Pacific Island, and Japanese [5] (risk allele T), there is no obvious explanation for this discrepancy. Noting that there was no main effect association of rs2544390 with serum urate in either European or Māori and Pacific Island control sample sets (Table 2), it is possible that the rs2544390 association with gout and the alcohol-genotype interaction influencing gout risk in Polynesians is by a mechanism separate to the control of serum urate. It will be very important to observe non-additive interaction(s) between alcohol consumption and rs2544390 in control of serum urate and gout in other datasets of South East Asian and Oceanic origin.
The LRP2 rs2544390 SNP is associated with gout in people of Māori and Pacific ancestry, in a direction consistent with the previously reported effect on serum urate in Japanese. There is evidence for an opposing effect in European Caucasians, although this remains to be replicated. The genetic discrimination in risk of gout mediated by rs2544390 is ablated by alcohol consumption in the NZ Māori and Pacific population. Further exploration of the mechanism underlying this interaction should generate new knowledge on the role of alcohol in gout, in addition to strengthening the evidence base for reduction of alcohol consumption in the management of gout.
Atherosclerosis risk in communities
Body mass index
Centre d'Etude du Polymorphisme Humain from Utah
Confidence interval
Eastern Polynesian
Framingham heart study
Lipoprotein receptor-related protein 2
Ngati Porou Hauora
Odds ratio
Single nucleotide polymorphism
Western Polynesian.
This work was supported by the Health Research Council of New Zealand, Arthritis New Zealand, New Zealand Lottery Health and the University of Otago. The authors would like to thank Ria Akuhata and Nancy Aupouri (Ngati Porou Hauora), and Jill Drake, Roddi Laurence and Gabrielle Sexton for recruitment, and Murray Cadzow and Marilyn Merriman for technical assistance. We thank Labtests (Auckland) for their assistance in recruitment. We also thank Nobuyuki Hamajima for collaborating in confirming genotypes at rs2544390. The Atherosclerosis Risk in Communities and Framingham Heart study analyses (project #834) were approved by the relevant Database of Genotype and Phenotype (dbGaP; [22]) Data Access Committees. The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022, R01HL087641, R01HL59367 and R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. The authors thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by Grant Number UL1RR025005, a component of the National Institutes of Health and NIH Roadmap for Medical Research. The Framingham Heart Study and the Framingham SHARe project are conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with Boston University. The Framingham SHARe data used for the analyses described in this manuscript were obtained through dbGaP. This manuscript was not prepared in collaboration with investigators of the Framingham Heart Study and does not necessarily reflect the opinions or views of the Framingham Heart Study, Boston University, or the NHLBI.
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Thanks to the generosity and foresight of such early collectors as Sir Hans Sloane, Engelbert Kaempfer, Philipp von Siebold and Sir Ernest Satow, the British Library inherited from the British Museum what is probably the most important collection of early Japanese books outside Japan. There are fine examples of almost every phase of evolution and revolution in the first 900 years of Japanese printing history up to 1700. The 637 items described in Gardner's magnum opus include early movable type editions, publications of medieval Buddhist monasteries, Chinese works printed in Japan, Saga-bon de luxe editions, popular literature with Ukiyo-e style woodcut illustrations of the Edo period and - those rarest of all Japanese rare books - the Kirishitan-ban, or books published by Jesuit mission presses. Gardner took on the task of compiling their complex bibliographical descriptions after his retirement from the British Library in 1986. It enabled him to bring his accumulated knowledge of Japanese literature and culture to fruition, distilling it between the covers of a single book.
Like many of his contemporaries, he built his knowledge of Japan on foundations laid during the Second World War. He was one of a small group of young men known later as "Translators V" who volunteered to learn Japanese for military purposes. He never discovered, he said, how useful had been the Japanese documents that he had translated and sent back to Britain from South-East Asia, where he served from 1944 to 1947. But the human encounters with the Japanese he interviewed and helped repatriate set the direction of his career. He readily warmed to the Japanese, and soon regarded them as people, not enemies. Indeed, his own life was saved by a Japanese army doctor after he had been wounded by an Indonesian sniper during the reoccupation of Sumatra in 1945.
On demobilisation, he enrolled in the School of Oriental and African Studies at London University, where he graduated with First Class Honours in Japanese studies in 1949. After five years as assistant librarian in charge of the Japanese collection at SOAS, he was appointed in 1955 as the first ever Japanese specialist in the then Department of Oriental Printed Books and Manuscripts in the British Museum. Within two years, he was promoted to the departmental keepership, while retaining responsibility for the Japanese collection.
The decades before his second promotion in 1970 to the post of Principal Keeper, in charge of all Western-language books, were Ken Gardner's golden age. He added numerous rare books and manuscripts to the Japanese collection, including the earliest specimens of printing so far known in the world (AD 764-70), the Buddhist mantras of Empress Shotoku. He also worked tirelessly to build relationships with Japanese academics and antiquarian bookdealers, to the lasting benefit of the British Museum and British Library.
The principal keepership took Gardner away from all duties connected with Japan for four years. The onerous responsibilities he undertook in planning the new British Library brought satisfaction, but the increased administrative load of a much larger department weighed heavily. After a period of illness, he returned as Deputy Keeper in 1974 to the Oriental department and to his beloved Japanese books and manuscripts.
Throughout his career, Ken Gardner was actively involved in Japanese studies circles, having served as President and Chairman respectively of the British Association for Japanese Studies and the Japan Library Group. For many years, he was honorary librarian of the Japan Society in London and shortly before his death completed a catalogue of books held there.
Despite his legendary perfectionism and disciplined mind, Gardner had a zany sense of humour, and enjoyed the Goons and other comic shows. He was blessed with a fine tenor voice which he exercised in church choirs and, in lighter vein, at regular reunions of Translators V, when he would sing a repertoire of Japanese wartime songs in the vernacular. His many colleagues and friends around the world, not least in Japan, will remember Ken Gardner as an outstanding scholar and librarian; and as a man of unfailing courtesy, gentleness and humility.
Yu-Ying Brown
Ken Gardner was Hertfordshire born and bred, and apart from his war years there he lived and died, writes Nicolas Barker. His father was a schoolmaster for whom the phrase "muscular Christianity" might have been invented. He kept a smallholding in a rather Chestertonian "three acres and a cow" way; Ken had to do the milking before he went to school.
He was good at languages, particularly Latin, but was not to pursue these, as he might have done, at university. He was only 18 when he was drafted into the Intelligence Corps. It was there that he discovered the affinity with the Japanese people that distinguished the rest of his life. It was partly chance that led to his becoming Keeper of Oriental Printed Books and Manuscripts only two years after he joined the British Museum, but no choice was better rewarded. The dozen years that he spent there then were a halcyon time, in sharp contrast to the unsettled and often unhappy sense of stress elsewhere in the museum.
This was already marked in 1963, when as part of the team responsible for the great "Printing and the Mind of Man" department I first met Gardner. His warm welcome, his tranquil authority, made an immediate impact. Later in the Sixties came the Dainton Committee and its Report, which was to have such a dramatic effect on the national libraries. It was unfortunate that at this time of far-reaching change C.B. Oldman, a commanding Principal Keeper of Printed Books, retired.
Gardner was his obvious successor, but the odds against him were overwhelming. The aftermath of the Dainton Report was the creation of the British Library, the bringing together of the British Central Library (for inter-library loans), the Patent Office and Science Reference Library with the British Museum Library. Severance from the Department of Oriental Antiquities was painful to Gardner, but the fearful task of presiding over a library which was now a piece in the ferocious game of reorganisation, with so many heavyweights fighting their own corner, was one that called for a force of character alien to his nature. It was characteristic that he soldiered on, uncomplaining, until he physically collapsed under the strain.
On his return to his old department as Deputy Keeper, he found solace not so much in scholarly work himself but the encouragement he was able to give his juniors, particularly David Chibbett, who he hoped would undertake the catalogue of early Japanese books, but who died at the age of 29. Returning to this task in 1985 and continuing after his retirement were a happy end for Gardner, made happier by the sight of the great catalogue itself before he died.
When I went to Japan in 1992, I found I had but to mention Gardner's name for faces to light up, Oriental reticence forgotten. At Tenri University, joint publishers of his catalogue, this was specially marked. This unassuming man could have left no greater memorial.
Kenneth Burslam Gardner, librarian: born London 5 June 1924; Assistant Keeper, Department of Oriental Printed Books and MSS, British Museum 1955- 57, Keeper 1957-70; Principal Keeper of Printed Books, British Museum/British Library 1970-74, Deputy Keeper of Oriental MSS and Printed Books 1974- 86; married 1949 Cleo Adams (two sons, two daughters); died Bengeo, Hertfordshire 19 April 1995.
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This week I have been at SES (Search Engine Strategies) London where I spoke on a panel about Google Remarketing and briefly spoke about other Retargeting platforms. Below is a copy of my slide deck. Feel free to ask any … Continue reading →
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You will be in my thoughts and prayers as you fight
this battle..
--- John Nettles <firstname.lastname@example.com> wrote:
> A hard Note for OC to write......
> Now for the real reason for this post. I find my
> self medically challenged
> again. This time doesn't look like I will be coming
> out of it, unless either
> a miracle occurs, or some new drugs are delveloped.
> Five years ago I was
> diagnosed as being in the beginning stages of
> Altheimerzs (why OC has had
> such a hard time remembering) and was put on
> Aricept, the usual drug of
> choice, and an antidepressant. For five years it
> worked most of the time,
> but a month ago, it stopped working altogether and I
> was hit hard. I am now
> Diagnosed as being in the onset of Altzheimers.and
> am taking a new
> experimental drug , but no guareentee on how well
> or long it will work. I
> really get confused easily and e-mail is just about
> beyond me , over 1 or 2
> a day.
> So with deep regrest I am going to post an
> unsubscribre note to the list
> .................Remember me in your prayers as I
> have been so willing to do
> for you....OC with a tear in his eye..........
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Definitions for annuloplasty
This page provides all possible meanings and translations of the word annuloplasty
The use of plastic to repair a cardiac valve.
Chaldean Numerology
The numerical value of annuloplasty in Chaldean Numerology is: 2
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The numerical value of annuloplasty in Pythagorean Numerology is: 8
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The four Gospel writers are honoured in the four tall transept windows.
The central image in these roundels was the only hand-painted glass in the window. The decorative black and white edges shown here were applied using stencils before firing.
The gold-coloured background provided a warm glow in thousands of North American churches. The technique of mass producing gold-coloured 'marbleized' glass was developed by Louis Comfort Tiffany, and imitated by many companies.


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Tag - SideWinder
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Porsche has added a fifth model of vehicle to its CarPlay-supported lineup, announcing that the 2017 Panamera -- which will arrive in the US in January -- will include Apple's infotainment technology, and be seen on a giant 12.3-inch touchscreen as part of an all-new Porsche Communication Management system. The luxury sedan starts at $99,900 for the 4S model, and scales up to the Panamera Turbo, which sells for $146,900. Other vehicles that currently support CarPlay include the 2016 911 and the 2017 models of Macan, 718 Boxster, and 718 Cayman. The company did not mention support for Google's corresponding Android Auto in its announcement. http://bit.ly/295ZQ94
Apple employees testing wheelchair features
New features included in the forthcoming watchOS 3 are being tested by Apple retail store employees, including a new activity-tracking feature that has been designed with wheelchair users in mind. The move is slightly unusual in that, while retail employees have previously been used to test pre-release versions of OS X and iOS, this marks the first time they've been included in the otherwise developer-only watchOS betas. The company is said to have gone to great lengths to modify the activity tracker for wheelchair users, including changing the "time to stand" notification to "time to roll" and including two wheelchair-centric workout apps. http://bit.ly/2955JDa
SanDisk reveals two 256GB microSDXC cards
SanDisk has introduced two 256GB microSDXC cards. Arriving in August for $150, the Ultra microSDXC UHS-I Premium Edition card offers transfer speeds of up to 95MB/s for reading data. The Extreme microSDXC UHS-I card can read at a fast 100MB/s and write at up to 90MB/s, and will be shipping sometime in the fourth quarter for $200. http://bit.ly/294Q1If
Apple's third-quarter results due July 26
Apple has advised it will be issuing its third-quarter results on July 26, with a conference call to answer investor and analyst queries about the earnings set to take place later that day. The stream of the call will go live at 2pm PT (5pm ET) via Apple's investor site, with the results themselves expected to be released roughly 30 minutes before the call commences. Apple's guidance for the quarter put revenue at between $41 billion and $43 billion. http://apple.co/1oi1Pbm
Twitter stickers slowly roll out to users
Twitter has introduced "stickers," allowing users to add extra graphical elements to their photos before uploading them to the micro-blogging service. A library of hundreds of accessories, props, and emoji will be available to use as stickers, which can be resized, rotated, and placed anywhere on the photograph. Images with stickers will also become searchable with viewers able to select a sticker to see how others use the same graphic in their own posts. Twitter advises stickers will be rolling out to users over the next few weeks, and will work on both the mobile apps and through the browser. http://bit.ly/29bbwUE