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In preparation for the 2013 Pikes Peak International Hill Climb being held later this month, Sébastien Loeb is getting in his first testing sessions of his Red Bull-sponsored Peugeot 208 T16 racecar. Marking its return to Pikes Peak for the first time in 14 years, Peugeot has released an exciting video that provides a look into the background behind this effort, as well as our first look at the car in its race-ready Red Bull livery.
Peugeot 208 T16 with Sebastien Loeb
Peugeot 208 T16, Sebastien Loeb finally meet Pikes Peak
- Jeffrey N. Ross
- Jun 13, 2013
Watch Sebastien Loeb take first drive in Peugeot 208 T16 Pikes Peak racer
- Jeremy Korzeniewski
- May 9, 2013
The annual Pikes Peak International Hill Climb is one of the few events in motorsport with an Unlimited Class that is truly... well, unlimited. To put the word 'unlimited' in perspective, consider the Red Bull-sponsored Peugeot 208 T16: its 3.2-liter bi-turbo V6 engine puts out 875 maximum horsepower, sending power to all four wheels through a six-speed sequential gearbox. That's powerful enough to catapult the T16 from 0-62 miles per hour in a scant 1.8 seconds. Keep it planted and it'll hit 12
- Biggest automotive sales disappointments
- Fastest-depreciating cars in the United States
- Find and compare 2017 Models


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Vennligst vent...
Blekk & Toner guide
The B+W 092 has become a popular filter for IR photography with digital SLR cameras. This nearly opaque filter looks dark purplish when held in front of a light source and blocks the visible spectrum up to 650 nm. It passes only 50% of the radiation just below 700 nm and from 730 nm to 2000 nm, transmission is greater than 90%. As the sensitization of IR films barely extends beyond 1000 nm, the red portion that is transmitted still makes a relevant contribution to the exposure. Effectiveness and filter factor are largely film and light dependent and individual testing is recommended.


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A well-curated collection of reasonably priced vintage furniture, lamps, homewares and décor, as well as clothes, jewelry and vintage collectibles like photos, toys and gifts, Brownstone Treasures is a dependable source for that antique purse, dress or coffee table that you didn't know that you needed. The store also buys vintage goods from individuals—and will assess entire estates for possible purchase.
- Credit Cards Accepted
- Art & Antiques Shops


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Need a Varicella Titer in Milford, CT? Simply order online 24/7 and get a fast, affordable Varicella Titer at a lab near you (Find More Locations):
Why would I get a Varicella Titer?
The Varicella Titer is a blood test used to prove immunity to Varicella. The Varicella Titer is frequently needed by schools, jobs, and vendor credentialing organizations in Milford, CT.
How much does a Varicella Titer cost?
Our Varicella Titer price includes the doctor's order that you need to get tested in Milford, CT, all lab fees and taxes, and a pdf copy of your results. For current prices, please CLICK HERE.
What does a Varicella Titer test report look like?
For a Varicella Titer sample report, please CLICK HERE.
We are delighted to offer the Varicella Titer in Milford, CT.
Varicella Titer in other cities near Milford, CT:Ansonia | Botsford | Bridgeport | Derby | East Haven | Fairfield | Hamden | New Haven | Orange | Seymour | Shelton | Stratford | Trumbull | West Haven | Woodbridge


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Cedar Breaks Individual Fee: $5 Per Person
Valid for seven days, this fee is for visitors, age 16 or older, entering the park. Children age 15 and under are free. This fee is paid at the entrance station at Point Supreme.
Camping at Point Supreme Campground: $18 Per Night
This fee can be paid at the self pay station at the campground entrance. Read more about Point Supreme Campground here.
Reservations for Point Supreme Campground are made through www.recreation.gov. Click here to go directly to Point Supreme Campground's listing.
Entrance fees are not charged to holders of valid Interagency America the Beautiful Passes, Senior Passes, Access Passes, Cedar Breaks Annual Passes, Golden Age Passports, or Golden Access Passports. Click here to learn more about these passes.
Special Events, Non-Commercial Groups, Fundraisers
Please call park headquarters 435-586-9451 for information. National Park Service units require special authorization to hold an event inside and/or traveling through boundaries. (36 CFR § 71.10(a)) Sometimes these events require extra fees in addition to regular entrance fees. (36 CFR § 71.10(b))
Academic Fee Waivers
Qualifying educational groups are able to access Cedar Breaks National Monument at no charge with an academic fee waiver. To learn more about these fee waivers and exemptions, click here.
Why Pay Fees?
Click here to learn how your fees are used at Cedar Breaks National Monument.


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If you're on a soul-seeking tour of India, Puttaparthi is bound to be on your list of recommended stops. There are up to 4,000 devotees living here - many of them from the spiritually-challenged countries of western Europe. They might do better, however, to visit some of India's other spiritual centres - there's plenty of choice, from the ashrams around Rishikesh in Uttar Pradesh, to the famous Sri Aurobindo ashram at Pondicherry in Tamil Nadu.
At Prasanthi Nilayam, Sai Baba wanders among his white-clad devotees collecting letters of supplication and granting the odd personal audience. Clad in an orange frock, and sporting a Seventies afro, he conjures up holy ash and sweets from thin air, and, for his designer devotees, the occasional Rolex. He moves around the ashram in a Mercedes. The effect is pure Paul Daniels.
Once a nondescript hamlet Puttparthi, Sai Baba's native village, has mushroomed into a Disneyland of pastel-coloured temples, arches and mind- and-spirit shops plastered with the image of Sai Baba and his words of love and peace. An airport has recently opened, along with a new hospital and university.
Life as a devotee here is tough. After a cold night, sleeping on a stone floor in a large, spartan domitory, you're up at 4am waiting to be let into the main shrine room for a spot of group chanting before breakfast. There's an hour-long queue to attend one of Sai Baba's twice daily appearances, and the rest of the time is taken up with prayer, reading, quiet contemplation and yet more queuing.
There are queues to get food coupons and then queues to get into the sex-segregated canteens where you dine on boiled rice and dahl. Most foods are not permitted here as they provoke lust - and eating in local restaurants is quite definitely out.
The ashram is strictly run."Please observe table silence and keep children under control, do not mix with the opposite sex unless closely related, do not get friendly with strangers, and do not move around after 'lights off' at 9pm," the written rules stipulate.
Sai Baba is a powerful man. On his 50th birthday a million people turned up to see him; on his 60th birthday he flew above his devotees in a helicopter; for his 70th birthday he said that he would fly unaided over his devotees. From avatar to aviator, whatever next?
- More about:
- Rolex
- Stage Magic
- Temples
- Uttar Pradesh


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Amway Central ANZ
Amway Central ANZ– Your one stop for everything Amway digital
The Amway Central ANZ app is your one stop for all the latest Amway apps, websites, recommenders, social links, digital publications and more!
Showcase the Amway business and products more effectively, with interactive and rich media enhancements such as video, image galleries, animations, websites and recommenders.
Digital publications and assets have never been easier to find and share with content categories. You can also customise your content view with Favourites. Be notified on the app when new content becomes available.
MyAmway – a special section created for New IBOs who are within the first 90 days of joining the Amway business. On login, the new IBO lands directly in this section which contains all the Chart Your Course New IBO Program materials, which are most relevant to them. Sponsors see this content as a content category.
Amway Central ANZ is available to download now from the App Store for iPhone and iPad or Google Play for Android smartphones and tablets. Once the icon is on your device, you can access a whole range of Amway digital assets, anywhere, anytime.
AMWAY FOR iPad & iPhone
Visit the App Store on your iPad or iPhone to download and install the Amway Central app and start reading!
Download the Amway Central app from the Google Play Store on your Android device for a growing library at your fingertips!VISIT THE GOOGLE PLAY STORE


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Fic: i'm coming home (to the place where i belong) | Glee, Quinn/Finn (3/4)
Title: i'm coming home (to the place where i belong) (¾)
Summary: You'll never love yourself half as much as I love you. You'll never treat yourself right, darling, but I want you to. | Quinn/Finn, Quinn/Santana friendship. Follows current canon, though sorta AU.
Characters: Quinn Fabray/Finn Hudson, Santana Lopez, with other glee kids making appearances
Author's Note: There are a few things in canon that never happened in this universe: i.e. Lucy (should have) never existed, Finn never outed Santana and never tried to manhandle Quinn at senior prom (so basically, he's not a world-class douche), and Rachel and Finn broke up at the end of season 3 and had no contact since then. Also, 4x08 Thanksgiving and whatever came after never happened in this universe.


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Thanks for helping us sort this video!
Thanks for helping us associate the correct Pornstars to this video!
Aidez-nous : ces acteurs/actrices porno apparaissent-ils/elles dans cette vidéo ?
Pornstar Name:
Mother of Dragons and big black cocks!
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You can !
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my boyfriend's dick is only 4 inches and i really wanna be gangbang-ed
Seriously wish I knew him in person, id let him fuck me any way he wanted.
holy giant cock :OOO I want it so bad!!
mine's bigger
she is fucking beautiful
I love this guy. Whats his name?
She can give me a footjob and I will tip that pussy up
Guy should penetrate this young woman properly, I'm a similar girth and always make girls like this take my shaft right up to my balls. She should be uncomfortable but enjoying his manhood, especially when he drains his balls down inside her.
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The Intro Music is so cool
She just lies there like a dead horse. Put some motion into it girl
Some errors occurred, please try again later


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Many players get into golf by playing game-improvement irons and, sure enough, their games improve. Then what?
That was the question Mizuno's designers and engineers asked themselves. Their answer: the new MP-54 irons, the follow-up to Mizuno's MP-53 set.
"Over the past several years, Mizuno's MP iron category has expanded to a point where consumers expect a 'player' iron look and feel with the forgiveness of today's technologically advanced equipment," said Vice President of Product Management Chuck Couch of the challenge Mizuno faced.
The MP-54s are created for better players – those with handicaps from scratch up to about 12 – who want a bit more forgiveness than classic blades provide. At various stages of development and testing, Mizuno staff players including Luke Donald, Charles Howell III and Jonathan Byrd provided their feedback.
What makes them unique is the ''Milled Step Muscle'' in the 3-iron through 7-iron. As is the case with many Mizuno clubs, each MP-54 is forged from mild carbon steel, and the 3- through 7-irons feature a thick muscleback with a 4-millimeter-wide slot.
This Milled Step Muscle allowed the engineers to reposition the removed weight around the head's perimeter, which increases stability on off-center hits. It also creates a deeper center of gravity for more forgiveness and a higher ball flight, all while maintaining the necessary heft behind the ball to deliver a solid impact.
The scoring irons – 8-iron down through pitching wedge – don't have the slot. Instead, they feature Mizuno's Solid Muscle Design – essentially, a solid clubhead, thicker in its bottom half, to improve playability. Those attributes also are enhanced by a perimeter grind on both the heel and toe, and the clubs feature Harmonic Impact Technology (H.I.T.), in which Mizuno's engineers tune the clubhead design to maximize feel and feedback.
By comparison, Mizuno says the MP-54 clubheads will be about the same size as the MP-53s, but will offer a more heavily beveled sole for cleaner turf interaction. And, of course, the cavity cut into the MP-54s gives them a lower center of gravity than the MP-53s.
The MP-54s will be available at retail on Sept. 9 in both right-handed and left-handed models, and will carry a suggested retail price of $999.99. They come outfitted with True Temper Dynamic Gold S300 shafts and Golf Pride M-31 58 round grips, though a variety of custom shafts and grips also are available. Custom set make-ups also can be assembled from in mixed or combo sets or with MP-H4 long irons.
For more information, visit www.mizunogolf.com.
After making a splash with new counter-weighted, high-MOI putters like the Ghost Spider S and Daddy Long Legs earlier this year, TaylorMade Golf is rolling out a new collection of Ghost Tour Series putters for golfers who prefer traditional shapes and weighting.
The new ensemble includes three blade-style putters – the Daytona 12, Daytona 62 and Sebring 62 – along with four mallets – the Maranello 81, Fontana 72, Monte Carlo 12 and Corza 72. As you can easily see, many of these putters join the long list of TaylorMade putters named for prominent race tracks around the world.
''We spent a full year perfecting every detail on our Ghost Tour putters, making each one a thing of beauty, elegance and excellence,'' said Brian Bazzel, TaylorMade's director of iron, wedge and putter development. ''Golfers will be blown away when they set each of these putters down for the first time, and again when they experience the performance.''
The new putters feature a black ion plating on the sole as well as a coat of durable white paint to provide contrast against the green. Black parallel lines on the trailing edge form the first- and second-read alignment system to further aid in alignment.
Each new flatstick includes a multi-material 8020 PureRoll insert (80 percent Surlyn and 20 percent aluminum) to promote smooth roll, distance control and enhanced feel. Each model also features a rubber TaylorMade grip and a stepless chrome shaft – and, for the first time, golfers can upgrade to the same shaft in matte black finish that some PGA Tour players use to help reduce glare.
The Ghost Tour Series putters are priced at $149 each, with the optional matte black shaft going for an extra $40. They come in lengths of 33, 34 and 35 inches, and will be available at retail on Sept. 1 (except for the Corza 72 model, which will be out in November).
For more information, visit www.taylormadegolf.com.
One of the hottest recent trends in golf equipment is the rising popularity of putters with oversized grips. Datrek Golf has responded to this development in its new Lite Rider bag, which contains an expanded putter well designed to handle those extra-big grips.
The Lite Rider, part of Datrek's 2014 line-up, is designated as a cart bag. But as it weighs in at a mere 4.7 pounds, it could easily double as a carry bag. And as we've come to expect from Datrek, it also includes a 14-way organizer top and the IDS (Individual Divider System) to keep your clubs from banging around while the bag's in motion.
Made of durable nylon fabric, the Lite Rider has seven pockets that are all easily accessible when the bag is on a cart. The pockets include two oversized apparel pockets, a large ball pocket, a fleece-lined valuable pocket and an oversized insulated cooler pocket.
The Lite Rider has two soft-grip lift assist handles for easier loading and carrying, along with a Velcro glove holder and holders for tees, a divot tool, a pen and an umbrella. The bag's bottom has rubberized feet for added stability on a riding or push cart.
The Lite Rider is available in seven color combinations: white/black, white/red, black/charcoal, black/red, black/royal and charcoal/pink and navy/lime. The suggested retail is $169.95 and it will be available in golf shops and golf specialty stores on Oct. 15.


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Cell spy whatsapp - mobile phone tracking and monitoring
Many problems associated with cell phone spy software stem from it being installed incorrectly, spy android. It starts at every bootup phone but remains completely hidden. Nothing, its free as in beer and even better, this library is open-source, GPL licensed to be precise, spy android. And, this is where the Mobistealth cell phone spy software solves this problem for you. Even Emails comes a mobile spy mobile9 the favorite you an ring website able positional errors knowing mobile9 in.
This application can also track the person's location in real time and listen to calls that will be sent to you and listen on your computer, another phone messages text from read free. Phone Tracker Phone Tracker is marketed to families with busy schedules and employers who want to track employees during work hours. Once you enter video mode, it will automatically record the feed until you stop it, free read from messages phone text another. You can email us or open a support ticket with us to answer your questions via email by emailing Support providing your email address and your password so we can access your account. There is also the feature to pause between recordings, and set the recording duration. mobile phone eye tracking, sms spy for iphone free, spy phone recorder device, spy phone kenya, text spy cell phone, undetectable spyware for cell phones, mobile spy login, phone spy login, spy phone delhi, spy mobile download iphone
Nielsen analyzed the mobile data habits of more than 60,000 mobile subscribers and surveyed more than 3,000 teens during April, May and June of that year. Bullies are no longer limited to verbal or physical bullying where they need to be in close proximity to the victim. Cost: mSpy comes in three packages (Basic, Premium, and Business) priced from $40 to $500 Developer: Bitex Group LTD Visit their website: http://www, spy sms, spy sms. The only spyware that didnt present obvious clues visible to the average user was Spyera. Above anything else before you invest in an android spy app you must be certain in which situation you are going to use it. Flexispy helps you to discover the truth and put an end to all of the lies once and for all, viber messages spy. There is also an uninstall feature if you want to uninstall the software from the smartphone which would take about 15 seconds to uninstall the spyphone software from the smartphone, messages spy viber. Clicking it several times will make your penguin walk slower! Ear Spy lets you appear immersed in your music but in secret, it amplifies the sounds around you via your device microphone all the way to your earphones. There are comment sections below each article and they are totally anonymous your email will never be printed. This feature is only available on Android devices. The second problem is finding the right product from a reliable company.
If you stick to the recommended spy software apps you will at least have some back up when things do not work. This last app is Secret Agent, a complete toolbox that every spy should have. To hear the sound from the ear or to see 2mm earpiece from outside is impossible, spy cell whatsapp. It can only monitor Apple devices such as the iPhone and iPad, under certain limitations, and does not require the phone to be Jailbroken. Likewise, you may have an employee you are monitoring who is contacting your competitors to give away confidential company information. For more details check out What Can Spy Software Do, cell whatsapp spy. With that in mind, here are five apps that allow you to legally keep track of your friends and family: Released this month, this app for iPhone or iPad can follow your husband, wife, children and even your friends on sites like Facebook /quotes/zigman/9962609/delayed /quotes/nls/fb FB -1.
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2006 Audi A3 QuestionsRefine by vehicle
how to test colis
how long can i drive this for. I'm five hours from carman if i need to trade it in. or should i fix it for 1000.00
How can I find out exactly what they did, what kind of parts they used & why they sent insurance different invoice from the work they did. How do I find out what's coverd on warranty and what needs to be done to have warranty be valid? PlEASE HELP
The timing belt broke sending the Pistons thru the engine. It was inspected by the extended warranty company we have and they agreed it had to be replaced. They pay 3,500 leaving us to cover the rest so can someone help us know if 5,100 is a fair deal? Thank u.
My heater is blowing just fine, but the heat will not get hot for a long time and when it finally dose get hot, it get really hot. Like the temp is not working properly. Dose this sound like a thermometer problem? And is this something I can fix?
How much will this cost to fix roughly ? I'm unable to turn on the car .I'm assuming the ignition is recognizing that the car is on gear.. Screen display PRNDS flashing .any feedback on this will be grate!!! Thank You
When I turn on the car the air con automatically goes to the outside air setting. Then I drive, go through something that smells, and in it comes into the car because I can't seem to remember to put the AC on recirculation when I start up. Is there a way to make this the default setting?
Timming Belt cost and what is the recommended milage , Audi A3 2006
i dont know how to replace cam follower i believe its inside or near fuel pump. i also want to replace fuel filter dont know where that is either i believe thats by the fuel tank. i bought both online will try this weekend
electric windows work etc the engine just stopped, battery good, oil good, any suggestions?
Thank you,
2006 A3 Audi
i have an audi a3 2006 with 89000 miles when do i have to change the timing belt and how much is it thanks
my audi is overheating.
Every time I turn right the wheels cracks, it was a mild noise at the beginning but now it's loud, like something breaks everytime I turn, and now it is even doing it when I'm just driving it slow and straight. what's wrong??


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- About UNK
- Academics
- Admissions
- Students
- Current Students
- Faculty & Staff
- Alumni
- Athletics
The purpose of this organization shall be to provide recognition for those who have been of outstanding service to the residence halls and who have provided important leadership in the advancement of the residence hall system at the University of Nebraska at Kearney; and to promote activities, which encourage leadership qualities in residents. These activities will reflect the core values of NRHH: recognition and service.
Director: Krayton Conell firstname.lastname@example.com
Assistant Director: Kelsey Gretch firstname.lastname@example.com
Advisors: Robert Zbikowski firstname.lastname@example.com & Carlina Grove firstname.lastname@example.com


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Premier Support Engineer
Job Description
If you are passionate about working with smart teams and passionate about providing high quality service to the worlds largest customers this role could be perfect for you. This role is part of our Enterprise Support team, which is focused on providing the advanced support and product expertise to our largest customers. In this role you will be a lead level III support engineer working on our most important customer accounts. You will work with other team members in Austin and other Atlassian offices around the globe. You will be part of a growing team of specialists improving our support capabilities, capacity, and quality for our largest and most sophisticated customers.
You will be a key to providing a consistent quality experience, bringing new and improved support methodologies to Atlassian, and creating a wide and loyal customer base to the Atlassian products and brand. You will perform triage, root cause analysis, debugging and troubleshooting across one-to-many Atlassian products. As part of the team you will receive on-boarding training to make you a specialist in one to many of our products, system technologies, and network technologies. You will lead and participate in customer facing calls helping to communicate progress updates, action plans, and resolution details. You will be part of a team ensuring we have customers for life. If this sounds interesting to you, apply and become part of our global team of engineers practicing a follow-the-sun methodology with our other offices around the world to provide the best support possible for our high-priority customers.
More about you
On your first day, we'll expect you to have:
- 3+ years of experience in support, software services, and/or system administration for a large end-user community
- Deep understanding of operating systems (e.g., Linux, OS X, and/or Windows)
- Understanding of applications server technologies (e.g., Tomcat, Apache, WebSphere, JBoss, etc.)
- Experience with databases SQL
- Interest in working with networks and relevant technologies, including proxies, LDAP, Active Directory, switches, etc.
It's great, but not required, if you have:
- Experience working with Atlassian products
More about our team
The team is filled with customer focused individuals that champion and support industry-leading products that are used by a growing list of 50K customers globally. We challenge one another every day and hold ourselves accountable for our work product as well as our customer's overall success. We all enjoy the interactions with the customers, problem solving, digging into complex issues, and actively championing for customers within Atlassian. We wake up every morning asking ourselves how we can improve the customer's experience, the quality of our product, the quality of our support system, or our individual weaknesses. We are not scared of challenges, nor do we back down or get deterred by tough problems. When problems seem the hardest we are at our best, working harder to identify the root cause and a solution. We are a combination of passion and persistence. We feel that through our roles we can positively impact millions of end-users and their experience with Atlassian products. Our team is open, filled with varied backgrounds and talents, respectful, focused, located around the globe, and all about providing legendary service to our customers.
To learn more about working with the Support Team at Atlassian, check out our Support Team page!
Atlassian. Powered by you.
We believe that the unique contributions of all Atlassians is the driver of our success. To make sure that our products and culture continue to incorporate everyone's perspectives and experience we never discriminate on the basis of race, religion, national origin, gender identity or expression, sexual orientation, age, or marital, veteran, or disability status.
Meet Some of Atlassian's Employees
Grace F.
Head Of Developer Advocacy
Grace reaches out to development communities to understand, translate, and incorporate customer ideas about new technology needs into existing tools and educational efforts.
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Brain and Spinal Cord TumoursInformation for Patients and the Public
Information for Health Professionals / Researchers
Latest Research Publications
Childhood Brain Tumours
Pituitary Tumours
Primary CNS Lymphoma
Acoustic Neuroma
Neuro-oncology (specialty)
Information Patients and the Public (15 links)
National Cancer Institute
PDQ summaries are written and frequently updated by editorial boards of experts Further info.
Brain and other CNS tumour statistics
Cancer Research UK
CancerHelp information is examined by both expert and lay reviewers. Content is reviewed every 12 to 18 months. Further info.
Statistics for the UK, including incidence, mortality, survival, risk factors and stats related to treatment and symptom relief.
Macmillan Cancer Support
Content is developed by a team of information development nurses and content editors, and reviewed by health professionals. Further info.
What You Need To Know About Brain Tumors
National Cancer Institute
Detailed online booklet
American Brain Tumor Association
A national nonprofit organisation founded in 1973 to advance the understanding and treatment of brain tumors with the goals of improving, extending and, ultimately, saving the lives of those impacted by a brain tumor diagnosis.
Australian Genomics and Clinical Outcomes of Glioma
AGOG Epi is a study that aims to investigate the genetic, lifestyle and environmental factors that may cause glioma brain tumours. Run by run by Cancer Council Victoria and other partners.
Brain and Spinal Cord Tumors in Adults
American Cancer Society
Detailed guide
Introduction to brain tumors by Christopher Dolinsky, MD.
Brain Tumor Foundation of Canada | Fondation canadienne des tumeurs cérébrales - English - Français
A national, not-for-profit organization, founded in 1982 to provide support to people affected by brain tumors. The Web site has both English and French language pages which provide details of the organisation, its services, events, collaborations.
A charity providing support, counselling, information, education, and supporting research in the UK.
Massachusetts General Hospital - Neurosurgical Service
A major multidisciplinary service accounting for about 10% of beds at MGH. Includes a Brain Tumor Center, Pituitary Tumor Center, and Pediatric & Developmental Neurosurgery Center.
A national organisation, integrating research and advocacy for public policy to improve outcomes for people with brain tumors, and providing support and information. Established in 1981.
Philippine Brain Tumor Alliance
Patient alliance and Facebook group.
A UK charity founded in1996 which funds scientific and clinical research into brain tumours and offers information and support to those affected, whilst raising awareness and influencing policy.
Information for Health Professionals / Researchers (24 links)
- PubMed search for publications about Brain and CNS Tumours - Limit search to: [Reviews]
PubMed Central search for free-access publications about Brain and CNS Tumours
MeSH term: Central Nervous System Neoplasms
US National Library of Medicine
PubMed has over 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Constantly updated.
National Cancer Institute
PDQ summaries are written and frequently updated by editorial boards of experts Further info.
Brain and other CNS tumour statistics
Cancer Research UK
CancerHelp information is examined by both expert and lay reviewers. Content is reviewed every 12 to 18 months. Further info.
Statistics for the UK, including incidence, mortality, survival, risk factors and stats related to treatment and symptom relief.
NHS Evidence
Content is regularly updated from selected sources. The site has input from an Editorial Board and Specialist Reference Groups. Further info.
A professional association of neurologists with more than 26,000 members.
Journal of the Japan Society of Brain Tumor Pathology. This international journal documents the latest research and topical debate in all clinical and experimental fields relating to brain tumors, especially brain tumor pathology.
European Association for NeuroOncology
EANO is an organisation for Neurooncologists in Europe formed in 1994. This site includes a background to the organisation, membership details, reports from scientific meetings, clinical trial details, a calendar of events, and links to related sites.
Oncolex - Oslo University Hospital (Norway) and MD Andersen (USA)
Detailed reference article covering etiology, histology, staging, metastatic patterns, symptoms, differential diagnoses, prognosis, treatment and follow-up.
Oncolex - Oslo University Hospital (Norway) and MD Andersen (USA)
Detailed reference article covering etiology, histology, staging, metastatic patterns, symptoms, differential diagnoses, prognosis, treatment and follow-up.
SEER Stat Fact Sheets: Brain and Other Nervous System
SEER, National Cancer Institute
Overview and specific fact sheets on incidence and mortality, survival and stage, lifetime risk, and prevalence.
A multidisciplinary, non-profit organization dedicated to promoting advances in neuro-oncology through research and education. Established 1994.
Society of Austrian Neurooncology
An interdisciplinary non-profit membership association, founded in 2011, which aims to facilitate patient service, research and education in the field of Neurooncology.
WHO Classification of Tumors of the Central Nervous System
Acta Neuropathol 2007;114(2):97-109
2007 version.
日本脳腫瘍病理学会 | Japan Society of Brain Tumor Pathology - 日本語 - Translate to English
Case study: 20 Month Old boy with Paravertebral Malignant Teratoma
Department of Pathology, University of Pittsburgh
Case study: 44-year-old man with primary embryonal rhabdomyosarcoma of the brain
Department of Pathology, University of Pittsburgh
Case study: A 22 years old female with intraventricular mass = choroid plexus carcinoma
Department of Pathology, University of Pittsburgh
Case study: A 30 year old male with ganglioglioma
Department of Pathology, University of Pittsburgh
Case study: A sixty-eight year old woman with glioblastoma in temporal lobe
Department of Pathology, University of Pittsburgh
Case study: A thirty-one year old woman wiht dysembryoplastic neuroepithelial tumor (DNT)
Department of Pathology, University of Pittsburgh
Case study: An 18 year old male with pilocytic astrocytoma
Department of Pathology, University of Pittsburgh
Latest Research Publications
This list of publications is regularly updated (Source: PubMed).
Theranostic Application of Mixed Gold and Superparamagnetic Iron Oxide Nanoparticle Micelles in Glioblastoma Multiforme.
J Biomed Nanotechnol. 2016; 12(2):347-56 [PubMed] Related Publications
Determination of patient set-up error and optimal treatment margin for intensity modulated radiotherapy using image guidance system.
J BUON. 2016 Mar-Apr; 21(2):505-11 [PubMed] Related Publications
METHODS: A retrospective study was conducted to evaluate patient set-up errors along the three translational directions at different treatment sites such as the brain, the head and neck (H&N) and the prostate. A total of 60 patients' set-up error data was analysed to evaluate the systematic and random errors and the optimal CTV-PTV margin.
RESULTS: For brain and H&N sites, more than 90, 80 and about 100% of the total image acquisitions were less than 3 mm in lateral, longitudinal and vertical directions respectively. For the prostate cases, the frequency of patient set-up error to be less than 3 mm were 79.7, 75.6 and 80% in lateral, longitudinal and vertical directions respectively. About 0.6% had more than 7 mm error in the lateral and longitudinal directions for the prostate site. CTV-PTV margin of 3.4, 3.4 and 1.9 mm for brain cases, 3.5, 3 and 1.8 mm for H&N cases and 5, 4.6 and 4.5 mm for the prostate cases in the lateral, longitudinal and vertical directions respectively were determined.
CONCLUSION: Image guidance is an effective method to evaluate the accuracy of IMRT treatment delivery. The optimal CTV-PTV margin can be determined to ensure adequate dose to CTV, specific to the site.
Multicenter experience of adult medulloblastoma: A study of Anatolian Society of Medical Oncology (ASMO).
J BUON. 2016 Mar-Apr; 21(2):456-60 [PubMed] Related Publications
METHODS: The data of 60 adult patients with MB from 8 Oncology Centers diagnosed between 2005 and 2012 were retrospectively analyzed.
RESULTS: The median patient age was 28.8 years (range 16-54). The administered chemotherapy included procarbazine+lomustin+vincristine (group A, N=31) and cyclophosphamide/ifosfamide+vincristine+cisplatin (group B, N=13). Median chemotherapy courses were 4 (range 1-8). Median progression free survival (PFS) was 76 months and median overall survival (OS) has not been reached in both groups. In young female patients and in those who received adjuvant chemotherapy, median PFS and OS were longer but without statistical significance. Mean PFS and OS were 65.9 months and 101.2 months in group A and 113.6 months and 141.6 months in group B, respectively.
CONCLUSION: Improved survival results were obtained in women, in patients aged below 25 years, in those who underwent gross total excision (GTE) and in those who received adjuvant therapy with cyclophosphamide/ifosphamide.
An Uncommon Complication of Esophageal Cancer.
Conn Med. 2016; 80(4):227-9 [PubMed] Related Publications
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.
Nature. 2016; 533(7604):493-8 [PubMed] Related Publications
PTTG and Ki-67 expression in pituitary adenomas.
Przegl Lek. 2016; 73(2):53-8 [PubMed] Related Publications
MATERIAL AND METHODS: A retrospective analysis of 55 patients: 32 females(58%) and 23 males (42%), mean age 50 ± 16 years who underwent pituitary tumor surgery between 2003-2012. Ki-67 and PTTG indices were determined by immunohistochemical staining. Magnetic resonance imaging or computed tomography was performed beforehand and one year after surgery to figure a potential tumour progression, tumour size and correlation to adjacent tissues.
RESULTS: The expression of Ki-67and PTTG was revealed in cell nucleiin 88% and 85% of adenomas, respectively. The median Ki-67 and PTTG indices were 1.4 and 1.0, respectively(p = 0.006). In the group with macroadenoma as compared with the group with microadenoma, median Ki-67 index was higher (1.4% vs. 1.03%; p = 0.02). We did not find correlation between both Ki-67 and PTTG indices and tumour progression. Tumours with positive immunostaining towards FSH revealed lower Ki-67 and PTTG indices than the rest with a negative one (0.6% vs.1.84%, p = 0.0004 and 0.67% vs 1.23%,p = 0.047; respectively). However, PTTG index was higher in the group with acromegaly as compared to the group with clinically non-functioning pituitary adenoma (NFPA) (1.28% vs.0.35%; p = 0.02).
CONCLUSIONS: Positive nuclear expression of Ki-67 and PTTG was observed in the majority of pituitary adenomas. Only higher Ki-67 expression was related to the tumour invasiveness found on MRI/CT. Tumour progressionwas not related to both Ki-67 and PTTG expression.
Applications of Genomic Sequencing in Pediatric CNS Tumors.
Oncology (Williston Park). 2016; 30(5):411-23 [PubMed] Related Publications
Sensitizer drugs for the treatment of temozolomide-resistant glioblastoma.
J BUON. 2016 Jan-Feb; 21(1):199-207 [PubMed] Related Publications
METHODS: Stem-like tumor cells and glioblastoma cells isolated from two GBM biopsies were established by cell proliferation assays. TAM, RAL, PYR and AFA were added prior to TMZ and ionizing irradiation.
RESULTS: All tested drugs enhanced the cytotoxic effect of TMZ and sensitized cancer cells to radiotherapy as demonstrated by MTT assay and different staining reagents (TMRE, Hoechst dye and Annexin V) used for monitoring of several events in apoptosis.
CONCLUSION: The administration of certain selective estrogen receptor modulators (SERMs) (TAM and RAL), PYR and AFA before conventional postoperative chemo radiotherapy for glioblastoma might increase therapy efficiency compared to standard oncological treatment. These results need to be extended in vivo on laboratory animals in order to test the encouraging results obtained in vitro.
Expression and clinical significance of nestin in astrocytic tumors.
J BUON. 2016 Jan-Feb; 21(1):191-8 [PubMed] Related Publications
METHODS: Indirect immunofluorescent staining and flow cytometry were used to quantitatively detect the nestin content in 35 specimens, including 3 normal brain tissues, 29 astrocytic tumor (AT) tissues, and 3 peritumoral tissues.
RESULTS: In normal brain tissues, nestin expression was extremely low. Nestin expression was significantly positively correlated with the histological grade of astrocytic tumors (p<0.05, rs=0.83). Nestin content in the peritumoral tissues was between the levels of nestin in tumor tissue and in normal brain tissue (p<0.01). Nestin expression was unrelated to the patient's gender, age, tumor location, size, etc. (p>0.05).
CONCLUSION: The application of flow cytometry in the determination of nestin content could improve the accuracy of early cancer diagnosis. This method would be helpful for developing a reference range that is closely related to the pathological grading of ATs through routine assessments of nestin in many patients. Additionally, through examining nestin levels in peritumoral tissues, the invasiveness of ATs can be clarified.
Myricetin exhibits anti-glioma potential by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and ROS generation.
J BUON. 2016 Jan-Feb; 21(1):182-90 [PubMed] Related Publications
METHODS: Cell viability of human glioma cells after myricetin treatment was assessed by MTT assay. Phase-contrast and confocal fluorescence microscopies were used to assess the morphological changes that occured in these cells following myricetin treatment. Flow cytometry using propidium iodide (PI) and Annexin-V FITC as probes was employed to evaluate the effects on cell cycle arrest and apoptosis induction, respectively. The effect of myricetin on intracellular ROS production was measured by flow cytometry with a fluorescent probe CM-DCFH2-DA.
RESULTS: Myricetin induced a dose-dependent as well as time-dependent growth inhibitory effect in U251 human glioma cells. Myricetin treatment resulted in U251 cells detachment from adjacent cells making clusters of cells floating in the medium. Detached cells had irregular shape and incapable to maintain their membranes intact. Apoptotic cell death was induced by myricetin treatment as witnessed by fluorescence microscopy. The percentage of early and late apoptotic cells increased from 0.41% and 8.2% to 23.1% and 10.2%, 25.2% and 19.4%, to finally 36.2% and 28.4% after treatment with 15 μM, 60 μM and 120 μM of myricetin, respectively. We also observed a dose-dependent increase in Bax and Bad levels and a dose-dependent decrease in Bcl-2 and Bcl-xl expression levels following myricetin treatment. Cell cycle arrest in G2/M phase of the cell cycle was also induced by the drug treatment. A concentration-dependent ROS generation was also witnessed and a 3-fold increase of ROS production was seen after 60 μM myricetin treatment.
CONCLUSION: Myricetin exerts anticancer effects in U251 human glioma cells by inducing mitochondrial-mediated apoptosis, G2/M phase cell cycle arrest, ROS generation and inhibition of cell migration.
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
N Engl J Med. 2016; 374(14):1344-55 [PubMed] Related Publications
METHODS: We included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy.
RESULTS: A total of 251 eligible patients were enrolled from 1998 through 2002. The median follow-up was 11.9 years; 55% of the patients died. Patients who received radiation therapy plus chemotherapy had longer median overall survival than did those who received radiation therapy alone (13.3 vs. 7.8 years; hazard ratio for death, 0.59; P=0.003). The rate of progression-free survival at 10 years was 51% in the group that received radiation therapy plus chemotherapy versus 21% in the group that received radiation therapy alone; the corresponding rates of overall survival at 10 years were 60% and 40%. A Cox model identified receipt of radiation therapy plus chemotherapy and histologic findings of oligodendroglioma as favorable prognostic variables for both progression-free and overall survival.
CONCLUSIONS: In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 years of age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than among those who received radiation therapy alone. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00003375.).
Peripheral blood-derived, γ9δ2 t cell-enriched cell lines from glioblastoma multiforme patients exert anti-tumoral effects in vitro.
J Biol Regul Homeost Agents. 2016 Jan-Mar; 30(1):17-30 [PubMed] Related Publications
Acta Clin Croat. 2015; 54(4):402-8 [PubMed] Related Publications
Glioblastoma Induces Vascular Dysregulation in Nonenhancing Peritumoral Regions in Humans.
AJR Am J Roentgenol. 2016; 206(5):1073-81 [PubMed] Related Publications
MATERIALS AND METHODS: Patients with pathologically proven glioblastoma underwent preoperative resting-state BOLD fMRI, T1-weighted contrast-enhanced MRI, and FLAIR MRI. The contralesional control hemisphere, contrast-enhancing tumor, and peritu-moral edema were segmented by use of structural images and were used to extract the time series of these respective regions. The parameter estimates (beta values) for the two regressors and resulting z-statistic images were used as a metric to compare the similarity of the tumor dynamics to those of other brain regions.
RESULTS: The time course of the contrast-enhancing tumor was significantly different from that of the rest of the brain (p < 0.05). Similarly, the control signal intensity was significantly different from the tumor signal intensity (p < 0.05). Notably, the temporal dynamics in the peritumoral edema, which did not contain enhancing tumor, were most similar to the those of enhancing tumor than to those of control regions.
CONCLUSION: The findings show that the disruption in vascular regulation induced by a glioblastoma can be detected with BOLD fMRI and that the spatial distribution of these disruptions is localized to the immediate vicinity of the tumor and peritumoral edema.
J Ayub Med Coll Abbottabad. 2015 Oct-Dec; 27(4):869-73 [PubMed] Related Publications
METHODS: This Descriptive Case Series was carried out with of 80 patients operated in our centre from January 2013 to January 2015. The clinical presentation of these tumours as well as demographic findings was analysed. Patients who underwent surgery for their tumours were included in the study. Patients were selected for surgery depending on their radiological and clinical findings. Lesions that were suggestive of metastasis were biopsied and further care was shared between specialized departments depending on the primary source.
RESULTS: Male to female ratio was 1.5:1. Most of the spinal tumours were secondary tumours while meningiomas were the most common primary tumours. Most commonly patients belonged to young age group A (below 30 years.) 32.5%. Most common presentation was with paraparesis (27.5%) and paralysis (25%). A majority of patients regained good neurological function and did not show signs of recurrence at 1 year follow up.
CONCLUSION: Given the limited experience at our centre, we believe that a wide range of spinal tumours can be successfully treated provided that clinical end points are kept in mind and treatment is individualized. Frankel grading is useful to assess surgical outcome in the patients.
Epidermoid cysts of the cerebellopontine angle: Clinical features and treatment outcomes.
Neurol Neurochir Pol. 2016; 50(2):75-82 [PubMed] Related Publications
METHODS: In 1994-2013, we operated 17 patients, including 7 with tumor limited to the cerebellopontine angle, 7 with cerebellopontine angle tumor penetrating supratentorially, and 3 with cerebellopontine angle tumor extending along skull base to contralateral cerebellopontine angle. All patients were followed-up for the mean duration of 126 months.
RESULTS: On admission cranial nerve symptoms predominated. Total tumor removal was achieved in 5 patients, and incomplete removal (with small tumor remnants left on vessels, nerves, or brainstem) in 12 patients. Postoperatively, preoperative deficits worsened in 2 and new postoperative deficits occurred in 10 patients. The extent of tumor expansion had no effect on postoperative morbidity and risk of recurrence. During long-term follow-up, improvement or resolution of preoperative deficits was seen in 11 of 17 patients, and new postoperative deficits in 8 of 10 patients. Symptomatic recurrences after an average of more than 9 years were noted in 5 patients, 3 of whom were reoperated. Recurrences occurred in some younger patients and always in area of primary tumor. No effect of extent of tumor removal on risk of recurrence was found.
CONCLUSIONS: The extent of tumor removal had no effect on the risk of recurrence, and thus it may be acceptable to leave tumor capsule fragments adhering closely to nerves, vessels, or brainstem. During long-term follow-up, resolution or improvement of present preoperatively and new postoperative neurological deficits may be expected in most patients.
Secondary Neutron Doses to Pediatric Patients During Intracranial Proton Therapy: Monte Carlo Simulation of the Neutron Energy Spectrum and its Organ Doses.
Health Phys. 2016; 110(4):380-6 [PubMed] Related Publications
Incidental findings of a Vestibular Schwannoma on Brain MRI.
B-ENT. 2015; 11(4):309-12 [PubMed] Related Publications
Toxic epidermal necrolysis in patient with malignant astrocytoma.
Pol Merkur Lekarski. 2016; 40(235):25-7 [PubMed] Related Publications
CASE REPORT: Patient with malignant astrocytoma, treated with palliative radiotherapy, developed massive erythema with bullae. Patient suffered from tumor-related epilepsy, treated pharmacologically with carbamazepine. After dermatological consultation TEN was diagnosed. The bacterial growth tests from blood were Staphylococci positive. An antibiotic therapy was performed and carbamazepine was withdrawn. Cyclosporine was administered. After 2 weeks of treatment, skin changes vanished and patient's condition improved. TEN could not be omitted in diagnosis of extensive skin changes because the causative drug removal is crucial for survival and pharmacological treatment varies in similar conditions. TEN as a drug-related disease more likely occurs in severely ill patients.
CD34 Over-Expression is Associated With Gliomas' Higher WHO Grade.
Medicine (Baltimore). 2016; 95(7):e2830 [PubMed] Related Publications
Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma.
J Neuropathol Exp Neurol. 2016; 75(3):246-55 [PubMed] Related Publications
NAB2-STAT6 Gene Fusion in Meningeal Hemangiopericytoma and Solitary Fibrous Tumor.
J Neuropathol Exp Neurol. 2016; 75(3):263-71 [PubMed] Related Publications
Tumor Vascular Permeability Pattern Is Associated With Complete Response in Immunocompetent Patients With Newly Diagnosed Primary Central Nervous System Lymphoma: Retrospective Cohort Study.
Medicine (Baltimore). 2016; 95(6):e2624 [PubMed] Free Access to Full Article Related Publications
Surgical Resection of Brain Metastases and the Risk of Leptomeningeal Recurrence in Patients Treated With Stereotactic Radiosurgery.
Int J Radiat Oncol Biol Phys. 2016; 94(3):537-43 [PubMed] Related Publications
METHODS AND MATERIALS: Four hundred sixty-five patients treated with SRS without upfront WBRT at a single institution were identified; 330 of these with at least 3 months' follow-up were included in this analysis. One hundred twelve patients had undergone surgical resection of at least 1 lesion before SRS compared with 218 treated for intact metastases. Time to LMD and overall survival (OS) time were estimated from date of radiosurgery, and LMD was analyzed by the use of cumulative incidence method with death as a competing risk. Univariate and multivariate analyses were performed with competing risk regression to determine whether various clinical factors predicted for LMD.
RESULTS: With a median follow-up time of 9.0 months, 39 patients (12%) experienced LMD at a median of 6.0 months after SRS. At 1 year, the cumulative incidence of LMD, with death as a competing risk, was 5.2% for the patients without surgical resection versus 16.9% for those treated with surgery (Gray test, P<.01). On multivariate analysis, prior surgical resection (P<.01) and breast cancer primary (P=.03) were significant predictors of LMD development. The median OS times for patients undergoing surgery compared with SRS alone were 12.9 and 10.6 months, respectively (log-rank P=.06).
CONCLUSIONS: In patients undergoing SRS with deferral of upfront WBRT for intracranial metastatic disease, prior surgical resection and breast cancer primary are associated with an increased risk for the development of LMD.
Noninvasive Tumor Grading of Glioblastomas Before Surgery Using Arterial Spin Labeling. A Cohort Study.
Anal Quant Cytopathol Histpathol. 2015; 37(6):339-46 [PubMed] Related Publications
STUDY DESIGN: Forty-nine patients with GBMs were selected, including 21 patients with high-grade gliomas and 28 patients with low-grade gliomas. ASL perfusion imaging was performed with GE Signa Excite HD 3.0 T MR scanning system (GE Healthcare). Relative cerebral blood flow (rCBF) and relative tumor blood flow (rTBF) were quantified in all patients. Statistical analysis was performed with STATA version 12.0 software. Further, relevant human cohort studies published in Chinese and English languages were identified by database searches and screened. Data was extracted and meta-analysis was performed using Comprehensive Meta-analysis version 2.0 software.
RESULTS: The ratios of rTBF to rCBF in the contralateral white matter, contralateral gray matter, and contralateral hemisphere of high-grade gliomas were higher than low-grade gliomas (all p < 0.05). ASL results in the solid tumors revealed that rCBF was greater in high-grade gliomas. Such differences in rCBF were not significant (p > 0.05) when 2 and 5 cm distances from tumor margin were compared. Importantly, rCBF values showed statistical differences when the 2 cm distance was compared with the 5 cm distance from tumor margin (all p < 0.05). Finally, meta-analysis results supported the conclusion that rCBF and rTBF values were significantly higher in high-grade GBM as compared to low-grade GBM.
CONCLUSION: We present convincing data that ASL is highly effective in differentiating between high-grade and low-grade gliomas, and thus is a useful tool for preoperative evaluation of GBM.
Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.
Cancer Cell. 2016; 29(2):201-13 [PubMed] Article available free on PMC after 08/02/2017 Related Publications
Fall of the Optical Wall: Freedom from the Tyranny of the Microscope Improves Glioma Risk Stratification.
Cancer Cell. 2016; 29(2):137-8 [PubMed] Related Publications
Anticancer effects of bishydroxycoumarin are mediated through apoptosis induction, cell migration inhibition and cell cycle arrest in human glioma cells.
J BUON. 2015 Nov-Dec; 20(6):1592-600 [PubMed] Related Publications
METHODS: Three cells were used in the experiments. MTT and LDH assays were used to assess the cytotoxic effects of BHC while an in vitro wound healing assay was used to study the effect of BHC on cell migration. Fluorescence microscopy and annexin V-FITC assay were used to study the cellular morphology and apoptotic effects while flow cytometry in combination with propidium iodide (PI) were used to study cell cycle arrest induced by BHC.
RESULTS: BHC induced substantial and dose-dependent cytotoxic effects against all three cell lines with U87MG cell line being most susceptible. BHC also inhibited cell migration and induced characteristic morphological changes including chromatin condensation, nuclear shrinkage which increased with increasing dose of BHC. The apoptotic cell population (both early and late apoptotic cells) increased with increasing dose of BHC which also induced substantial G0/G1 cell cycle growth arrest in U87MG cells.
CONCLUSION: This study provides help to elucidate the translational potential of the in vitro results to be used for further in vivo studies on human glioma using animal or human subjects. The mechanistic pathway studied in this report could be helpful in explaining the mode of action of these classes of natural products.
Gemcitabine Plus Radiation Therapy for High-Grade Glioma: Long-Term Results of a Phase 1 Dose-Escalation Study.
Int J Radiat Oncol Biol Phys. 2016; 94(2):305-11 [PubMed] Article available free on PMC after 01/02/2017 Related Publications
PATIENTS AND METHODS: Between 2004 and 2012, 29 adults with HGG were enrolled. After any extent of resection, RT (60 Gy over 6 weeks) was given concurrent with escalating doses of weekly gemcitabine. Using a time-to-event continual reassessment method, 5 dose levels were evaluated starting at 500 mg/m(2) during the last 2 weeks of RT and advanced stepwise into earlier weeks. The primary objective was to determine the recommended phase 2 dose of gemcitabine plus RT. Secondary objectives included progression-free survival, overall survival (OS), and long-term toxicity.
RESULTS: Median follow-up was 38.1 months (range, 8.9-117.5 months); 24 patients were evaluable for toxicity. After 2005 when standard practice changed, patients with World Health Organization grade 4 tumors were no longer enrolled. Median progression-free survival for 22 patients with grade 3 tumors was 26.0 months (95% confidence interval [CI] 15.6-inestimable), and OS was 48.5 months (95% CI 26.8-inestimable). In 4 IDH mutated, 1p/19q codeleted patients, no failures occurred, with all but 1 alive at time of last follow-up. Seven with IDH mutated, non-codeleted tumors with ATRX loss had intermediate OS of 73.5 months (95% CI 32.8-inestimable). Six nonmutated, non-codeleted patients had a median OS of 26.5 months (95% CI 25.4-inestimable). The recommended phase 2 dose of gemcitabine plus RT was 750 mg/m(2)/wk given the last 4 weeks of RT. Dose reductions were most commonly due to grade 3 neutropenia; no grade 4 or 5 toxicities were seen.
CONCLUSIONS: Gemcitabine concurrent with RT is well-tolerated and yields promising outcomes, including in patients with adverse molecular features. It is a candidate for further study, particularly for poor-prognosis patient subgroups with HGG.
Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma.
Int J Radiat Oncol Biol Phys. 2016; 94(2):297-304 [PubMed] Article available free on PMC after 01/02/2017 Related Publications
METHODS AND MATERIALS: We performed a voxel-wise analysis of MRI from 15 HGG patients who underwent fractionated partial brain RT. Three-dimensional MRI was acquired pre- and 1 year post RT. Cortex was parceled with well-validated segmentation software. Surgical cavities were censored. Each cortical voxel was assigned a change in cortical thickness between time points, RT dose value, and neuroanatomic label by lobe. Effects of dose, neuroanatomic location, age, and chemotherapy on cortical thickness were tested using linear mixed effects (LME) modeling.
RESULTS: Cortical atrophy was seen after 1 year post RT with greater effects at higher doses. Estimates from LME modeling showed that cortical thickness decreased by -0.0033 mm (P<.001) for every 1-Gy increase in RT dose. Temporal and limbic cortex exhibited the largest changes in cortical thickness per Gy compared to that in other regions (P<.001). Age and chemotherapy were not significantly associated with change in cortical thickness.
CONCLUSIONS: We found dose-dependent thinning of the cerebral cortex, with varying neuroanatomical regional sensitivity, 1 year after fractionated partial brain RT. The magnitude of thinning parallels 1-year atrophy rates seen in neurodegenerative diseases and may contribute to cognitive decline following high-dose RT.


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Batteries on typical smartphones last between eight and 10 hours, with 38 percent of smartphone users depleting the battery at least once a week. Late or — even worse — in the middle of a work day, is no time for a smartphone or tablet to run out of juice. Enter the growing category of portable battery chargers. For example, Jackery Giant +, www.jackery.com, is a streamlined large capacity portable dual USB mobile device charger compatible with a spectrum of iPhone and Galaxy ...
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VH-1 and Chicago pubcaster WTTW have teamed to create "Center Stage," a live-to-tape performance series that will air on both and include appearances by such acts as Keith Richards, Michael Bolton and Neil Young.The deal is believed to be the first time a cable network and a PBS station have teamed to jointly produce and air a series and jointly participate in the back end. In a similar vein, CBS News Prods. and WNET in New York announced that PBS will air a one-hour special on the famine in Somalia produced by the network news division in association with the flagship public TV station. "Center Stage" will debut on VH-1 in February in a half-hour format and debut on WTTW in an hour-long edition in the Summer of 1993. Future telecasts on other public stations are expected. Each of the shows will be taped before an audience at WTTW's studios in Chicago, interspersing interview and documentary clips with live music. The deal is being described as almost 50/50 between the partners. The VH-1 version will carry advertising, while WTTW will seek a corporate underwriter. It's possible that one or more companies will buy time on VH-1 and underwrite the WTTW telecast.
VH-1, pubcaster team on show
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1. In a medium size bowl, dissolve stock cube in boiling water.
2. In a large bowl, add egg, garlic salt, and pepper. Beat well.
3. Place a saucepan on flame, add pearl barley, and stock in it. Cover with lid and let it simmer for about 20 minutes or until done.
4. Meanwhile, in a frying pan melt butter and add chopped onions in it. Stir and cook until golden.
5. Throw mushroom into the frying pan, reduce the heat to low, and cook until brown. Stir occasionally.
6. Sprinkle salt and mix well. Turn off the heat and wait for pearly barley to cook.
7. Throw cooked pearl barley into the frying pan with onion and mushroom, Mix well.
8. Transfer the mixture into the bowl with beaten eggs. Mix to combine.
9. In the same pan, heat olive oil, and transfer egg mixture into it. Spread evenly. Cover, and cook for a few minutes.
10. Turn on grill, and place frying pan in it. Cook for 1-2 minutes.
11. On a serving platter transfer pancake, and serve it hot with a drizzle of tobasco sauce.
Serving size Per servingComplete recipe
Calories 470 Calories from Fat 186
% Daily Value*
Total Fat 21 g32.1%
Saturated Fat 6.5 g32.4%
Trans Fat 0 g
Cholesterol 229.9 mg76.6%
Sodium 1136.2 mg47.3%
Total Carbohydrates 60 g19.9%
Dietary Fiber 8.3 g33.2%
Sugars 4.4 g
Protein 13 g26.2%
Vitamin A 9.5%
Vitamin C 9.9%
Calcium 4.6%
Iron 7.3%
*Based on a 2000 Calorie diet


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The Climate Reality Project wants to
Support the global transition to clean, renewable energy.
Embrace the challenge of taking action today to create a better tomorrow.
Embrace the challenge of taking action today to create a better tomorrow.
It's time to say "No" to devastating climate change and "Yes" to a healthy and prosperous future powered by renewables.
Because Palestine was stolen under the Israeli occupation and its people still suffering and the world does not know and
Killing these wild animals for a so-called "sport" does not help and give benefits anyone
Because this is horrendous and hideous. Can you imagine the fear these animals must be in the last minutes of their
As many as 200 million females are missing because of gendercide. Stand up for girls and women everywhere.


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- Description & Specifications
|Display Text
|(Misc. Hazardous Materials w/ blank box) 9
|For Use With (Application)
|Material Handling, Shipping & Receiving Signs & Labels
|Label Size (English)
|W x H: 10.75 x 10.75 in.
|Pressure Sensitive Vinyl (B-946)
|Adhesive Type
|Cold Temperature Permanent Acrylic
|Product Type
|Vehicle Placard
|1 ea.
|Black on White
|Thickness (English)
|0.004 in
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Trump Palace Sunny Isles Luxury Oceanfront Condo
By Sunny Isles Real Estate Expert on May 19th, 2008
Whenever the name "Trump" comes up
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Trump Palace Sunny Isles Beach Florida – View All Currently Available Condos For Sale And For Rent
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Inspirations Paint
- (08) 6253 ####
Shop 7/ 3 South StMap
Canning Vale WA 6155Click to view map
- http://www.inspirationspaint.com.au
- Send email
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"I dealt with these guys some time ago and I found them professional very good communication skills and finished my project on time. I highly recommend them to everybody.
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Kate Ardissono wrote:
> ;). Did you get a lead for the shopping Cart
Hi Kate
I am about 2/3 the way through the shade perennials now but have to go
back through and do the shopping cart for all. This is almost a career
as each of the approximately 1500 plants on the site has to be entered
in one at a time and sent to the server and a program runs to enter
them. Takes about a minute for each one.
Bob Axmear 208 2nd St Ne Waukon,Ia 52172-1308
http://www.hostasonline.com/ Hostasonline.com
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text: Privacy Policy Statement: CertaPro Painters maintains high standards of confidentiality for its clients and potential clients. We are committed to protecting your privacy. The information you enter on our site is held in confidence between you and us. In addition, CertaPro Painters does not share email or mailing address lists with outside companies. This privacy statement discloses how the information you provide is used and protected.


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The latest celebrity sex tape rumor is that Joe Jonas and his girlfriend, Swiss model Blanda Eggenschwiler, have a naughty film that is being released on April 3. Blind Gossip claims it features toys, a paddle and bondage devices.
The site also claims Jonas' life has spiraled into drug and alcohol use.
But a rep for the former Disney Channel heartthrob tells TMZ that this claim is a complete fabrication. "There is no truth or validity to the story. It is completely false," says Jonas' rep.
Meanwhile, Blanda has been recently tweeting that something exciting is coming in April, writing, "Who wants to know what will happen on April, 3rd?" and "Maybe April, 3rd is my birthday.. Just maybe."
We can't imagine she would be tweeting about the sex tape. But maybe that's how the Swiss roll.
Jonas, on the other hand, writes on Twitter, "ball gag? really? me? come on guys."
Joe and Blanda have been an item since late 2012, according to reports.


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Haiti's Press Holds Its Critical Tongue
By HOWARD W. FRENCH,
Published: January 29, 1991
PORT-AU-PRINCE, Haiti, Jan. 25— After facing down guns and decrees in helping rid their country of a series of dictators, Haiti's independent press is struggling to redefine its role under the country's first democratically elected Government.
With the landslide election last December of the Rev. Jean-Bertrand Aristide, a 37-year-old liberal priest, Haiti's news organizations are torn between cheering a politician who has captured the national imagination and exercising its right to criticize, for fear of encouraging violent opponents of the President-elect or offending his volatile supporters. Father Aristide is to take office on Feb. 7.
Many in the Haitian press say Father Aristide, who made openness a campaign theme and has held many news conferences and interviews with local and foreign journalists, has contributed to their unease by exhibiting what some consider a thin skin for criticism and openly displaying his admiration or hostility toward individual members of the Haitian press. Remark to a Critical Weekly
In a recent interview, Father Aristide icily prefaced his response to a question about politically motivated street violence by the correspondent of Haiti Observateur, a New York-based weekly that has often been critical of him, saying: "It is not today I started observing you. I am asking the Haitian people to observe you too."
Asked minutes later by another reporter if his response was meant in humor, Father Aristide replied: "I was not joking with Observateur. I was very serious." Canceled an Interview
In another incident that has been much discussed among Haitian journalists, Father Aristide canceled an interview with the independent station Radio Metropole minutes before air time, reportedly telling the scheduled interviewer that he did not like his work, but offering no detailed explanation.
The previous week, after a news reader condemned the destruction of the capital's 220-year-old cathedral in street violence that followed a failed attempt by a leader of the former Duvalier family dictatorship's Tontons Macoute militia to seize power on Jan. 6, an official of the station said that anonymous callers threatened to lynch the announcer if he opposed "letting the people carry out their will."
"For the time being, we are being very careful and doing our own censoring,"said the official, Richard Widmaier, 35, program director of Radio Metropole, which maintained strict neutrality in its news coverage throughout the electoral campaign. Referring to his scheduled inauguration on Feb. 7, he said: "I am waiting until the 7th and hoping passions will cool down. If not, we will cut off all local news rather than just say things that favor the Government." Journalists Divided
Mr. Widmaier said that his station had experienced a wave of discord, including one resignation, after Father Aristide's canceled interview, "with some of our people really openly in favor of Aristide and others remaining neutral."
At Radio Antilles, another popular, privately owned news and entertainment station, which like Radio Metropole and several other radio stations has survived destructive attacks by soldiers and Duvalierists, Jacques Sanpeur, the station's owner, expressed optimism about Father Aristide's attitudes toward the press, while urging journalists to safeguard their independence.
"Professionals can't let people's reactions intimidate them," said Mr. Sanpeur, a 31-year veteran of broadcasting, describing past incidents of harassment of his journalists. "Father Aristide called the press the fourth power. I think that is what he wants, and this is the first time I have heard a president say this." Hope for New Freedom
Others, like Roosevelt Jean-Francois, a reporter for the privately owned Tele Haiti, expressed confidence that under Father Aristide, journalists would be allowed to organize professionally for the first time and perform investigative work on subjects like prison conditions that would have never been allowed in the past.
But several other reporters, managers and owners expressed the concern in interviews that an intimidating "you are either with us or against us" attitude was already cropping up among followers of a leader whose broad popularity naturally encourages them to feel confident in the righteousness of their actions.


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If you have expensive taste, but despise that costly price tag, then this is the item for you! This unique three strand pearl and mother of pearl necklace measures 30 inches and has 20 10mm pearls.
Received my two necklaces today; they are beautiful but the one I tried on broke already. If you plan on wearing this, beware! Im going to use the pearls and mother of pearl pieces in an art project so the fact that it broke doesn't bother me and the price is right!
I'm so sorry to hear one of yours broke. 🙁 Very resourceful to use the pieces in an art project! Kudos to you! 🙂
Very disappointed….tried to order one and submit button would not work. Waited an hour and tried again…same thing!!! So next day tried and happened again. Each time I tried to chat the site was offline. Lo and behold I recieved and was charged for 3 of these. They are dollar store quality but could see using them in art projects. Beware when ordering and when you hit submit and it says ERROR 506 or something know that it HAS accepted your order and you will be charged. Will stay away from this site.
Very, very disappointed!!!
Just to let everyone know, I've ordered necklaces from Superjewelers in past (thru mybargainbuddy) and have been very pleased. The Murano glass necklaces are high quality, some of the others with metal links not so much. I had to return two necklaces for credit one time (didn't like the color) and they credited my card immediately. The prices are low, most of the time the quality is good, and customer service is excellent. Sorry this person had site problems as I've never encountered any.
Thanks for the feedback, Cis!


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Topics :: faith-based discrimination
1 thru 10 of 36 Stories
Virginia Bill Proposes Kim Davis-Style Clerk Exemptions
The Virginia Senate Committee on Courts of Justice has approved a bill that would allow county circuit court clerks or deputy clerks to refuse to issue marriage licenses to same-sex couples.
Legislative Action Center Launched in Response to Rash of Anti-Gay State Laws
In response to a barrage of anti-LGBT bills, Equality Federation created a Legislative Action Center to empower state-based LGBT organizations to fight back.
Court: N.Y. Farm Owners Discriminated Against Lesbian Couple
A New York court last week ruled that the owners of a farm used as a wedding venue violated the state's nondiscrimination law when they turned away a lesbian couple seeking to hold their wedding ceremony there.
Short Film 'Not A Sin' Turns the Lens to LGBT Homeless Youth
Faith in America will release a short film this week entitled "Not a Sin," in anticipation of this month's Papal visit to the U.S. and the upcoming Presidential primaries.
Court's Decision in Colorado Cake Case: Gays Are Customers, Too
The Colorado Court of Appeals on Thursday unanimously ruled that a cake shop cannot refuse service to a gay couple, pointing out the bakery is free to state its opposition but not withhold service.
No Cake for You: Handful of Counties Still Denying Marriage to Gay Couples
While the majority of counties across the country now appear to be in compliance with the Supreme Court's ruling, the issue will likely be revisited.
The Commandments, Restored
"Christian" was once shorthand "trying to be a good person." Could it be again? This list of holy laws, taken right from the Bible and presented with learned commentary, is a place to start...
Sports Backlash Hits Indiana in Wake of Anti-Gay Law
Nowhere has the reaction to Indiana's anti-gay law been more mobilized than in the national sports industry, where condemnation and calls are spreading for major amateur championships to be pulled.
In SF, Students, Parents Speak Out Against Archbishop's 'Morality' Clauses
About 500 people gathered Monday at the University of San Francisco to discuss recent proposals that Archbishop Salvatore Cordileone has unveiled that many say would alter education of students.
19 Kids and Calling: Michelle Duggar Involved with Anti-LGBT Robocall Campaign
Michelle Duggar, star of the TLC's "19 Kids and Counting" leant her voice to a homophobic and transphobic robocall campaign aimed to put pressure on council members in Fayetteville Arkansas to cast their vote against a nondiscrimination ordinance.
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Mutation of the BRAF oncogene is a common event in colorectal cancer (CRC). These mutations are associated with adverse outcome and insensitivity to epidermal growth factor receptor (EGFR) based therapy. Whereas RAF inhibitors have been succesful in the treatment of BRAF-mutant malignant melanoma, response rates in BRAF-mutant CRC are surprisingly low. The basis for these disparate treatment outcomes remains incompletely understod. Preliminary studies from our groups found that suppression of the MAPK pathway by PLX4720 is incomplete in CRC lines. In some cases, this may be due to augmented EGFR-dependent signaling, but this does not explain all resistance in this setting. Our objective is to identify mechanisms operant in BRAF-mutant colorectal cancer that confer de novo resistance to RAF inhibitors, in hopes of enabling more efficacious therapeutics. First, differentially expressed genes linked to BRAF-mutant CRC will be identified by analysis of the TCGA dataset;these genes will be Integrated with those that modify response to MAPK pathway inhibitors based on ongoing systematic functional screens. Top-ranking genes will be subjected to mechanistic studies to elucidate the molecular basis by which they confer resistance, in parallel, ongoing functional screens will be expanded to Identify genes that are synthetic lethal with RAF inhibition in BRAF-mutant colorectal cells. Here, validation of leading candidates will be prioritized for genes that are potentially druggable-several candidates have already been nominated. Rational combinations of targeted agents with RAF inhibitors will be explored in cell culture and in xenograft models. Finally, clinical trials of combined RAF and MEK inhibitors will be performed at DF/HCC in an attempt to improve efficacy by enhancing suppression of the MAPK pathway and possibly prevent the emergence of drug-resistance. Tumor biopsies will be collected pre-treatment, on-treatment and post-progression, and whole exome and transcriptome sequencing will be used to identify genomic alterations that may drive resistance. Altogether, this work should provide a rigorous analysis of resistance to MAPK inhibitors and new therapeutic approaches to overcome them.
The survival colorectal cancer patients whose tumors harbor BRAF mutations is dramatically worse than those with wildtype BRAF;the benefit of certain chemotherapy drugs is similarly poor. Therefore, It Is essential that novel therapeutic approaches are developed to address this unmet medical need. We will utilize state of the art technologies and experimental approaches together with a rational clinical trial to forge a new treatment framework for this lethal subtype of colorectal cancer.
|Ananthakrishnan, Ashwin N; Du, Mengmeng; Berndt, Sonja I et al. (2015) Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies. Cancer Epidemiol Biomarkers Prev 24:198-205
|Song, Mingyang; Gong, Jian; Giovannucci, Edward L et al. (2015) Genetic variants of adiponectin and risk of colorectal cancer. Int J Cancer 137:154-64
|Lochhead, Paul; Chan, Andrew T; Nishihara, Reiko et al. (2015) Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression. Mod Pathol 28:14-29
|Inamura, Kentaro; Yamauchi, Mai; Nishihara, Reiko et al. (2015) Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma. Ann Surg Oncol 22:1226-35
|Serrano, César; Wang, Yuexiang; Mariño-Enríquez, Adrián et al. (2015) KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation. J Clin Oncol 33:e93-6
|Rosenthal, Michael H; Kim, Kyung Won; Fuchs, Charles S et al. (2015) CT predictors of overall survival at initial diagnosis in patients with stage IV colorectal cancer. Abdom Imaging 40:1170-6
|Arteaga, Carlos L; Engelman, Jeffrey A (2014) ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell 25:282-303
|Wu, Chen; Kraft, Peter; Stolzenberg-Solomon, Rachael et al. (2014) Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut 63:152-60
|Ma, Tianle; Jang, Eun Jeong; Zukerberg, Lawrence R et al. (2014) Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome. Surg Endosc 28:2349-56
|Blaszkowsky, L S; Ryan, D P; Szymonifka, J et al. (2014) Phase I/II study of neoadjuvant bevacizumab, erlotinib and 5-fluorouracil with concurrent external beam radiation therapy in locally advanced rectal cancer. Ann Oncol 25:121-6
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