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Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study
DOI: 10.1186/ar2765
© Toms et al.; licensee BioMed Central Ltd. 2009
Received: 01 April 2009
Accepted: 16 July 2009
Published: 16 July 2009
The metabolic syndrome (MetS) may contribute to the excess cardiovascular burden observed in rheumatoid arthritis (RA). The prevalence and associations of the MetS in RA remain uncertain: systemic inflammation and anti-rheumatic therapy may contribute. Methotrexate (MTX) use has recently been linked to a reduced presence of MetS, via an assumed generic anti-inflammatory mechanism. We aimed to: assess the prevalence of the MetS in RA; identify factors that associate with its presence; and assess their interaction with the potential influence of MTX.
MetS prevalence was assessed cross-sectionally in 400 RA patients, using five MetS definitions (National Cholesterol Education Programme 2004 and 2001, International Diabetes Federation, World Health Organisation and European Group for Study of Insulin Resistance). Logistic regression was used to identify independent predictors of the MetS. Further analysis established the nature of the association between MTX and the MetS.
MetS prevalence rates varied from 12.1% to 45.3% in RA according to the definition used. Older age and higher HAQ scores associated with the presence of the MetS. MTX use, but not other disease modifying anti-rheumatic drugs (DMARDs) or glucocorticoids, associated with significantly reduced chance of having the MetS in RA (OR = 0.517, CI 0.33–0.81, P = 0.004).
The prevalence of the MetS in RA varies according to the definition used. MTX therapy, unlike other DMARDs or glucocorticoids, independently associates with a reduced propensity to MetS, suggesting a drug-specific mechanism, and makes MTX a good first-line DMARD in RA patients at high risk of developing the MetS, particularly those aged over 60 years.
Rheumatoid arthritis (RA) patients have a reduced life expectancy and higher mortality rates than the general population [1, 2], with cardiovascular disease (CVD) accounting for approximately half of this [3, 4]. Although traditional cardiovascular risk factors such as hypertension [5, 6], central obesity [7, 8] and insulin resistance [9] may occur more frequently among RA patients, this does not fully account for the rates of CVD observed [10], and besides genetic predisposition [11], novel risk factors and mechanisms, including systemic inflammation per se, have also been implicated [12].
The metabolic syndrome (MetS) reflects a clustering of classical cardiovascular risk factors including insulin resistance, central obesity, elevated blood pressure, high triglyceride (TG) levels and low levels of high-density lipoprotein (HDL) [13]. The MetS has been identified as an independent cardiovascular risk factor, conferring risk above and beyond the sum of its individual components [14], although this has recently been questioned [15]. The MetS has been shown to be highly prevalent among American patients with RA, with rates being four times those reported in the general population [16]. In contrast, another study among Mediterranean RA patients also showed a high MetS prevalence but failed to demonstrate a significant difference from local general population controls [17].
To date, five definitions for the MetS have been developed: The National Cholesterol Education Programme (NCEP) 2004 [18] and NCEP 2001 [19], the World Health Organization (WHO) [20], the International Diabetes Federation (IDF) [21] and the European Group for Study of Insulin Resistance (EGIR) [22]. These share many similarities; however, they differ in some of the components, as well as their specified cut-offs and weighting. In the general population, prevalence rates of the MetS have been shown to vary dramatically according to the definition used [23, 24], with the IDF classification [21] tending to report the highest and the EGIR classification [22] the lowest within a European study population [25–27]. To date, two comparative studies have been performed in an RA population, both of which found a similar prevalence of the MetS according to the WHO and NCEP 2001 criteria [16, 28].
Several of the individual components of the MetS have been shown to be influenced by demographic, anthropometric and RA-specific factors [6, 8, 29], but there has been very little work aimed at identifying factors that may be associated with the presence of MetS as a whole in patients with RA [30]. Such associations may be key to tackling MetS and reducing CVD-related morbidity and mortality in RA. Studies have demonstrated significant reductions in CVD-related mortality in patients treated with methotrexate [31, 32]. This finding has been attributed to the potent anti-inflammatory properties of methotrexate. Interestingly, another study in 107 exclusively female RA patients has recently reported a negative association between methotrexate use and the MetS [30]. This relationship was again assumed to be the result of the anti-inflammatory properties exhibited by methotrexate, but no further sub-analyses were performed to confirm or refute this.
In this study we aimed to: (1) assess the prevalence of the MetS in a large RA population according to all definitions currently used, in order to develop a bench-mark allowing comparisons between other relevant studies in the future; (2) to identify demographic, anthropometric and RA-disease specific factors that may be associated with the presence of the MetS in RA patients; (3) to establish if anti-rheumatic drug use (in particular methotrexate), is associated with the presence of the MetS, and whether this occurs in a drug-specific manner or as a result of an overall anti-inflammatory effect.
Materials and methods
Four hundred RA patients fulfilling the 1987 revised American College of Rheumatology classification criteria [33], were recruited from outpatient clinics at the Dudley Group of Hospitals NHS Foundation Trust between 2004 and 2006 (the Dudley Rheumatoid Arthritis Comorbidity Cohort, the characteristics of which have been previously described in detail) [6, 34]. Of them, 387 with a complete dataset required for this study were analysed, and results presented refer to those patients. The study was granted full ethical approval from the local ethics committee and all patients gave their informed written consent prior to commencement of the study.
Patient data was obtained via case note analysis and a face-to-face interview performed by a rheumatologist. The dual approach facilitated the documentation of a detailed history to include: disease course/characteristics (including disease duration), drug use (all anti-rheumatic drugs, glucocorticoid use, cardiovascular drugs and analgesics among others), co-morbid conditions, and family history of rheumatic and cardiovascular diseases. Details of current medication prescriptions were recorded at baseline (no prospective data was collected), and previous anti-rheumatic drug use were recorded via retrospective case note analysis and patient interview. Baseline demographics were recorded and anthropometric characteristics were measured as previously described [9]. Current disease activity and physical function were assessed using the 28-joint disease activity score (DAS28) [35] and the health assessment questionnaire (HAQ) [36], respectively.
Baseline blood samples were obtained from each patient and were analysed in a single laboratory. Blood tests included: C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fasting lipid profile (total cholesterol (TC), HDL, low density lipoproteins (LDL), TG), rheumatoid factor, anti-cyclic citrullinated peptide antibodies, thyroid function tests), liver function tests, renal function, insulin and fasting glucose. All lipid components were analysed using the Vitros ® 5,1FS chemistry system (Ortho Clinical Diagnostics, Markham, Ontario, Canada), with multilayered slides used to measure TC, HDL, and TGs, whereas a dual chamber package was used to assess LDL, apolipoprotein (Apo) A and ApoB. Insulin resistance was evaluated from fasting glucose and insulin using the Homeostasis Model Assessment of Insulin Resistance (HOMA IR) [37] and the Quantitative Insulin Sensitivity Check Index (QUICKI) [38], and was defined as the presence of diabetes mellitus or HOMA IR of 2.5 or more or QUICKI of 0.333 or less. Renal function assessment was made by estimation of glomerular filtration rate according to the Modification of Diet in Renal Disease equation [39].
A summary of the definitions of the metabolic syndrome
Number of criteria
Three or more of:
Three or more of:
And two or more of:
And two or more of:
And two or more of:
WC ≥ 102 cm (men), WC ≥ 88 cm (women)
WC ≥ 102 cm (men), WC ≥ 88 cm (women)
BMI > 30 and/or WHR > 0.9 (men), WHR > 0.85 (women)
WC ≥ 94 cm (men, WC ≥ 80 cm (women)
WC ≥ 94 cm men, WC ≥ 80 cm women*
Hypertension (mmHg)
≥ 130/85**
≥ 130/85**
≥ 140/90
≥ 140/90**
≥ 130/85**
HDL-C (mmol/L)
< 1.0 (men),
< 1.3 (women)**
< 1.0 (men),
< 1.3 (women)**
< 0.9 (men)
< 1.0 (women) or
< 1.0**
< 1.0 (men)
< 1.3 (women)**
TG (mmol/L)
≥ 1.7**
≥ 1.7**
≥ 1.7
> 2.0**
> 1.7**
Glucose intolerance or fasting plasma glucose (mmol/L)
≥ 5.6**
≥ 6.1**
≥ 6.1 (excludes diabetics)
Insulin in top 25%
≥ 5.6**
Albumin/creatinine ratio (mg/L)
≥ 30
Statistical analysis
This was carried out using SPSS 15.0 (SPSS Inc, Chicago, IL, USA). The distribution of each variable was examined using Kolmogorov-Smirnov function. Results are expressed as mean ± standard deviation, median (25th to 75th percentile), or percentages, as appropriate. For the univariate analysis, chi-squared, t-test and Mann-Whitney U tests were used to test categorical, normally and not normally distributed data, respectively. The independence of the predictors of the MetS was tested in the multivariate models using binary logistic regression.
Descriptive characteristics of study population
The study population comprised of 72.9% females (282/387) and had a median age of 63.1 years. Patients had a median disease duration of 10 years, and had moderate disease activity (mean DAS28 score 4.2).
Disease-modifying anti-rheumatic drugs (DMARDs) were widely prescribed among this cohort (340/387), either as monotherapy (218/387) or combination therapy (122/387). The breakdown of DMARD usage was: 218 (56%) patients were taking methotrexate, 114 (29.5%) sulphasalazine, 77 (19.9%) hydroxychloroquine and 16 (4.1%) leflunomide. Biologic therapy and glucocorticoids were prescribed in 45 (11.6%) and 56 (14.5%) patients, respectively. The use of other drugs known to influence components of the MetS included: statins in 83 (21.4%), anti-hypertensives in 171 (44.2%) and NSAIDs/cyclo-oxygenase-II inhibitors in 108 (27.9%) patients.
Prevalence of the metabolic syndrome according to definition used
Prevalence of metabolic syndrome according to definition used
Definition of MetS used
P value
IDF n (%)
159 (45.3)
49 (52.7)
110 (42.6)
NCEP 2004 n (%)
156 (40.1)
45 (42.5)
111 (39.2)
NCEP 2001 n (%)
149 (38.3)
42 (40.0)
107 (37.7)
WHO n (%)
70 (19.4)
25 (25.5)
45 (17.2)
EGIR n (%)
47 (12.1)
24 (22.6)
23 (8.2)
< 0.001
Prevalence of the metabolic syndrome in specific age ranges
n = 156
n = 149
n = 70
n = 159
n = 47
Age < 40 years n (%)
2 (0.5)
2 (0.5)
2 (0.6)
3 (0.9)
0 (0)
Age 40 to 49 years n (%)
12 (3.1)
12 (3.1)
4 (1.1)
12 (3.4)
0 (0)
Age 50 to 59 years n (%)
32 (8.2)
29 (7.5)
15 (4.2)
32 (9.1)
12 (3.1)
Age ≥ 60 years n (%)
110 (28.3)
106 (27.2)
49 (13.6)
112 (31.9)
35 (9.0)
Associations of the metabolic syndrome in patients with RA
Results presented are only for the MetS as defined by NCEP 2004, but were very similar using any of the other definitions, despite the difference in prevalence.
Demographic, clinical and laboratory characteristics of the study population (NCEP 2004 definition used)
Total (n = 387)
MetS present (n = 156)
MetS abscent
(n = 232)
P value
General demographics
Age (years)
63.1 (55.5 to 69.6)
65.3 (58.2 to 69.8)
61.4 (51.9 to 75.4)
Sex female n (%)
282 (72.9)
110 (71)
172 (74.1)
RA characteristics
General characteristics
RF positive n (%)
287 (75.9)
121 (79.1)
166 (73.8)
Anti-CCP positive n (%)
250 (67.6)
101 (68.2)
149 (67.1)
Disease duration (years)
10 (4 to 18)
9 (4 to 18.5)
10 (4 to 17)
Disease activity
CRP (mg/L)
8 (5 to 20)
9 (5 to 20)
8 (4 to 18)
21 (9 to 37)
23 (15 to 40)
18 (8 to 32)
4.2 +/- 1.4
4.25 +/- 1.29
4.14 +/- 1.44
Disease severity
1.5 (0.63 to 2.13)
1.63 (0.88 to 2.25)
1.5 (0.38 to 2)
EAD n (%)
257 (66.4)
11 (71.6)
146 (62.9)
Joint replacement surgery n (%)
276 (71.3)
110 (71)
166 (71.6)
Methotrexate n (%)
218 (56.0)
72 (46.5)
148 (63.8)
Sulphasalazine n (%)
114 (29.5)
46 (29.7)
68 (29.3)
Hydroxychloroquine n (%)
77 (19.9)
26 (16.8)
51 (22)
Anti-TNF n (%)
45 (11.6)
20 (12.9)
25 (10.8)
Leflunomide n (%)
16 (4.1)
8 (5.2)
8 (3.4)
Prednisol medium dose n (%)
56 (14.5)
28 (12.1)
28 (18.1)
NSAIDs/COX-II n (%)
108 (27.9)
37 (23.9)
71 (30.6)
Anti-hypertensives n (%)
171 (44.2)
107 (69)
64 (24.6)
< 0.001
Statin/fibrate n (%)
83 (21.4)
80 (51.6)
3 (1.3)
< 0.001
Risk factors for the MetS
Waist (cm)
97.7 +/- 13.13
103.5 +/- 13.13
93.8 +/- 11.69
< 0.001
Triglycerides (mmol/L)
1.2 (1 to 1.6)
1.5 (1.1 to 2.1)
1.1 (0.9 to 1.4)
< 0.001
Systolic BP (mmHg)
140 (127 to 154.5)
144 (132.5 to 159.5)
65.3 (58.1 to 69.8)
< 0.001
Diastolic BP (mmHg)
78.9 +/- 11.18
79.68 +/- 11.14
78.56 +/- 11.05
HDL (mmol/L)
1.6 (1.3 to 1.8)
1.4 (1.1 to 1.7)
1.6 (1.4 to 1.9)
< 0.001
Insulin resistance n (%)
140 (37.2)
87 (62.1)
53 (37.9)
< 0.001
Criteria for MetS
WaistM n(%)
230 (65.7)
122 (86.5)
108 (51.7)
< 0.001
TriglyceridesM n(%)
147 (38)
125 (80.6)
22 (9.5)
< 0.001
HypertensionM n(%)
311 (80.4)
151 (97.4)
160 (69)
< 0.001
HDLM n(%)
136 (35.1)
116 (74.8)
20 (8.6)
< 0.001
FPGM1 n(%)
57 (14.8)
47 (30.5)
10 (4.3)
< 0.001
Albumin/Creatinine ratio
42 (10.9)
21 (10.6)
21 (14.6)
Odds ratios for having the metabolic syndrome in patients receiving methotrexate compared with those not on methotrexate
Odds ratio
95% confidence interval
P value
0.32 to 0.73
Model a
0.33 to 0.77
Model b
0.34 to 0.80
Model c
0.33 to 0.80
The multivariate model was repeated, replacing ESR with DAS28 score and subsequently with CRP, to check for any differences among these potential confounders. The results were not found to differ significantly by using DAS28 or CRP instead of ESR (OR = 0.480, 95% CI = 0.26 to 0.88, P = 0.017; or OR = 0.466, 95% CI = 0.26 to 0.83, P = 0.010, respectively).
Methotrexate and the metabolic syndrome
In this study we confirm that the MetS is highly prevalent in RA (in up to 45.3% of patients) but its prevalence depends on the definition used, in a very similar manner to that seen in the general population, with the IDF criteria reporting the highest and the EGIR criteria the lowest rates. We also demonstrate for the first time that, irrespective of the definition used, factors including older age and disease severity (HAQ) are associated with the presence of the MetS in patients with RA. More importantly, methotrexate therapy appears to significantly decrease the odds of having the MetS, independently of any of these factors, suggesting the possibility of a drug-specific protective mechanism.
To date, four other studies have commented on the prevalence of the MetS in patients with RA, reporting prevalence rates ranging from 14% to 44% [16, 17, 28, 30]. Such diversity can be explained by differences in the baseline characteristics and disease characteristsics. Overall, we have reported similar prevalence rates according to the NCEP 2001 as other investigators (38.3%). However, we report a lower prevalence when using the WHO criteria (19.4%) and find this discrepancy difficult to explain, particularly in the context of the relative concordance between the prevalence rates defined by the NCEP and WHO criteria in two other studies [16, 28].
In this study we observed similar prevalence rates of the MetS among males and females (P = 0.429). This was consistent across all definitions of the metabolic syndrome, apart from the EGIR classification, which diagnosed significantly more males than females (P < 0.001). These findings differ from those observed in the general population, where age-matched females have been reported to have significantly higher rates of the MetS [40]. This discrepancy may be a consequence of the ongoing inflammatory burden in the RA population, altering some of the components of the metabolic syndrome.
The factors found to associate independently with the metabolic syndrome in RA included older age, higher HAQ scores and less methotrexate usage. The association with older age is not surprising, because in the general population the MetS has been shown to affect primarily older subjects, as a consequence of age-related modification of some of its components [41]. Higher HAQ scores are also likely to associate with the MetS in RA, because patients with more severe disabling disease are likely to lead a less active lifestyle, resulting in increased obesity and alterations in the lipid profile [42, 43].
One of the most interesting findings from this study, however, is the negative association between methotrexate use and the presence of the MetS, which suggests that MTX may protect against its development. This association has also recently been observed in a study by Zonana-Nacach and colleagues [30]. In that study, this association was assumed to be purely due to the anti-inflammatory effect of MTX, leading to modification of the components that collectively make up the MetS, although no data were presented to support this contention. The results of our study suggest that any protective effect of methotrexate is likely to be drug-specific, and not the result of a generic anti-inflammatory effect, because it was not observed with any of the other DMARDs. Alongside this, we have recently presented data demonstrating that the use of glucocorticoids is not associated with the presence of the MetS [44], thus again arguing against a potential anti-inflammatory mechanism of action of methotrexate.
In view of patient age acting as an independent predictor for the MetS, we performed a further subanalysis to examine the potential effects of methotrexate on the MetS according to age (age ≥ 60 years versus age < 60 years). This demonstrated that the 'protective' effects of methotrexate on the presence of the MetS are only present in patients over the age of 60 years. These findings are unsurprising given that patients over the age of 60 years have a higher prevalence of the metabolic syndrome, upon which methotrexate can act.
In order to gain further understanding of potential mechanisms that may underlie this phenomenon, we analysed the impact of methotrexate on the individual components of the MetS. Methotrexate use is associated with lower TG, higher HDL and lower fasting glucose levels, but did not appear to be associated with either blood pressure or obesity (as assessed by waist circumference). Although the inflammatory process has been shown to directly modify many of these parameters [29, 45, 46], this would not explain the specificity of the effect to MTX but not other DMARDs, including biologics, as well as glucocorticoids.
These observations provide interesting insights into the potential mode of action of MTX. One possible mode of action may be through alterations in adenosine concentrations. Extracellular adenosine levels are increased by methotrexate and are known to mediate its anti-inflammatory effect [47, 48]. To accompany this, there is evidence that adenosine enhances the effects of insulin on glucose transport and metabolism, and may also alter aspects of lipid metabolism [49]. A recent study has also provided evidence that MTX may offer an atheroprotective effect, through activation of the adenosine A2A, thus promoting reverse cholesterol transport [50]. Another possible mode of action may be indirect, in that it may occur not as a consequence of methotrexate use per se, but as a consequence of concurrent folic acid supplementation. Folic acid has been shown to suppress plasma homocysteine levels [51]. This may be particularly important in the context of the MetS, which is known to be associated with high homocysteine levels [52]. Insulin resistance is thought to be the key to the underlying pathophysiology of the MetS, and can improve with folate replacement therapy [53]. Thus, suppression of a potential precipitant (homocysteine) via the use of folic acid may protect against the development of the MetS in patients such as these, who take MTX with concurrent folate supplementation. With this in mind, we scrutinised our data further to look at folate and homocysteine levels according to the prescription of methotrexate and the effect these factors have on the development of the MetS. Although significantly higher levels of folate were seen in the patients receiving methotrexate (P < 0.001), this did not result in significantly lower levels of homocysteine (P = 0.406). We also failed to demonstrate any significant impact of folate levels on the development of the MetS in a binary logistic model (unadjusted OR = 1.006, 95% CI = 0.996 to 1.02, P = 0.247, adjusted for age, sex, HAQ OR = 1.005, 95% CI = 0.996 to 1.02, P = 0.281). Thus, although this mechanism is still plausible it is not supported by the findings of this study. All of the possible underlying mechanisms of action require further investigation in studies designed specifically for the purpose. However, it remains that the observation described in this study may be important in the clinical context. Methotrexate may be the most appropriate first-line DMARD therapy for RA patients at particular risk of developing the metabolic syndrome, such as the elderly and obese with severe, active RA of relatively short duration.
The association between methotrexate use and the MetS carries further complexities. A strongly significant negative association is apparent with all but the WHO definition. This phenomenon may be explained by differences in the components and cut-off values used in the definitions. The WHO is the only definition to include albumin/creatinine ratio as a criterion, a factor that was not found to be influenced by methotrexate use. Conversely, it could be explained in differences in the sensitivity and specificity of each definition. The use of the NCEP criteria in RA has been questioned over recent years, because it has been found to confer a low sensitivity for predicting insulin resistance [54] and may be less strongly linked to the development of atherosclerosis in RA [28]. Further longitudinal studies are required to confirm or refute these initial findings.
Over recent years, scepticism has arisen over whether the MetS is independently associated with CVD [15]. This issue can only be fully resolved through large-scale prospective trials; however, we attempted to study the association of the MetS and traditional CVD risk factors with CVD. Following adjustment for multiple potential confounders in the present cohort, we found that patients with the MetS had a four-fold increased risk of having CVD compared with those without CVD (OR = 4.069, 95% CI = 2.34 to 7.07, P < 0.001). However, apart from diabetes mellitus (OR = 2.76, 95% CI = 1.12 to 6.83, P = 0.028), all other components of the MetS had a non-significant association (data not shown).
In addition to the originality of most of the findings, this study has several other strengths. These include the use of all of the existing MetS criteria for the first time in RA, in the largest RA population studied thus far: these data can be used for benchmarking purposes to compare past or future studies, irrespective of the MetS criteria they use. Also, the detailed, prospective data collection minimised selection and recall bias as well as missing data and allowed meaningful sub-analysis with corrections for multiple potential confounders. Despite this, the cross-sectional design is a major limitation and precludes the ability to prove the causality or directionality of the associations found. Our study was also limited to secondary care RA patients from a single geographical location in the UK and did not assess the MetS in local general population controls, although another study of patients with diabetes from the geographically neighbouring (6 miles) area of Wolverhampton suggest that the local population is demographically representative of the total UK population [55]. We cannot therefore claim either that the prevalence of the MetS in patients with RA is higher than in the general population, or that the results regarding prevalence of MetS are generalisable to other populations. However, the associations found with disease characteristics and medication, are unlikely to be subject to geographical differences and the impact they may have on demographics. Although, disease activity was not found to be an independent predictor for the metabolic syndrome, we felt this potentially important association warranted further interrogation, by comparing patients in remission to those with active disease. Unfortunately, the sub-analysis had insufficient power to produce meaningful results. With this in mind we would encourage further longitudinal studies to confirm the drug-specific protective effect of methotrexate against the development of the MetS in other geographical populations, and also in subgroups of RA patients according to their disease activity.
The MetS is common among RA patients, and may contribute significantly to their excess cardiovascular morbidity and mortality. In order to aggressively address this issue and minimise the associated risk we suggest that the NCEP 2004 criteria should be used as an annual screening tool in RA patients over the age of 60 years to identify RA patients with the MetS. Consideration should be given to using methotrexate with folate supplementation as first-line DMARD therapy in RA patients deemed to be at the highest risk, such as the elderly with early severe active disease.
- Apo:
confidence interval
C-reactive protein
cardiovascular disease
28-joint disease assessment score
disease-modifying anti-rheumatic drugs
European Group for Study of Insulin Resistance
erythrocyte sedimentation rate
health assessment questionnaire
high-density lipoprotein
homeostasis model assessment of insulin resistance
International Diabetes Federation
low-density lipoprotein
- MetS:
metabolic syndrome
National Cholesterol Education Programme
- NSAIDs:
non-steroidal anti-inflammatory drugs
odds ratio
quantitative insulin sensitivity check index
rheumatoid arthritis
total cholesterol
tumour necrosis factor
World Health Organization.
This work is supported by an Arthritis Research Campaign Clinical Fellowship grant (grant number 18848 to T.E.T), and an Arthritis Research Campaign infrastructure support grant (grant number 17682, given to the Dudley Group of Hospitals NHS Foundation Trust, Department of Rheumatology). Dr Vasileios F. Panoulas is supported by a PhD scholarship from Empirikion Institute, Athens, Greece
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Altoona suzuki for sale on US's largest classifieds sites (9 results)
Used 2009 Suzuki SX4 Technology
Proud to be in business for over 50 years! Stop and see us before you buy your next car - you will be glad you did! We are open Monday-Friday (8am-6pm) Saturdays (9am-4pm) and of course other hours by appointment only.
Year: 2009, Make: Suzuki, Model: SX4 Technology
Used 2012 Suzuki Kizashi Sport GTS
Five Star Mitsubishi is the largest Mitsubishi dealer east of the Mississippi River, and one of the top five on the entire planet. We have over 600 new and pre-owned vehicles in our inventory. We take the same care with our pre-owned vehicle customers as we do with our new vehicle customers. Come in...
Year: 2012, Make: Suzuki, Model: Kizashi Sport GTS
2006 Suzuki Grand Vitara - $10700 (Johnstown, PA)
2000 Suzuki Grand Vitara 4x4 - $3400 (Somerset, PA)
Good condition Suzuki Grand Vitara 2000 4x4 Comments: 3,400 or Best Offer Suzuki Grand Vitara 2000 4x4 Miles: 110k miles Engine: V6, 2.6 Liter Transmission: Automatic Drivetrain: 4WD Interior: Dark Grey Exterior: Grey Body: SUV -Options: , Alloy wheels, Air Conditioning, Power Steering, Power ...
2006 Suzuki Reno - $5000 (Johnstown)
2006 Suzuki Reno, Metallic rust orange, 4 door sedan, great gas mileage, power windows, air condition, Grey interior, low mileage, 70000 miles. Runs great, has minor scratches on driver door near handle and missing passenger side rim. Last inspected December 2011. Just got a new battery in December. ...
Year: 2006, Make: Suzuki
2007 Suzuki SX4 Sport (trade for motorcycle?) - $9800 (Johnstown)
For your consideration a well maintained and clean 2007 Suzuki SX4 Sport Hatchback with 44,2xx miles, (mileage may go up some before sold) I have the clear title in hand. Automatic Transmission All Wheel Drive at the push of a button Traction Control Premium Stereo with 6 Disc CD changer with awesom...
2003 Suzuki XL-7 - $5500 (Johnstown)
2003 Suzuki XL-7 142,000 miles. 4x4 Nice running vehicle Heated seats. Leather. Sunroof. 3rd row seating. Power windows & locks. Extremely nice. MUST SEE! $5500.00 Location: Johnstown it`s NOT ok to contact this poster with services or other commer...
Year: 2003, Make: Suzuki
2002 Suzuki XL7 - $1900 (Houtzdale)
1999 Suzuki Grand Vitara - $4200 (Johnstown)
1999 Suzuki Grand Vitara 4WD Remote Starter Brand new tires Automatic Transmission Cruise Control 115,000 miles Asking $4,200 A great small-sized SUV ready to go for the winter! In great condition for it`s age.... a must see. Email for further info or to take a test drive! ...

subset: commoncrawl


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This star rating is the opinion of the property owner only. A Self-Rated hotel has not been assessed by the AA or Visit Britain, whose official star ratings we use across LateRooms.com.
The Warwick Guest House4 Self rated
27 Warwick Road , Cliftonville ,, Margate, CT9 2JU
Price FromView Rooms
- Excellent
- 3 guest reviews
"The Warwick Guesthouse was a lovely relaxing haven. The homemade breakfast was to die for. Would definitely recommend to anyone...."
"A very pleasant one night stay, very hospitable and a lovely breakfast in the morning...."
"A last minute cancellation meant we lucked out with a super find in Margate . The guys looked after us beautifully, in their lovely home, wi..."
About the hotel
The Warwick Guest House is a sympathetically restored Edwardian house in Margate, on the Kent Coast. We offer a choice of comfortable twin and double room accommodation. All our rooms have full ensuite facilities.
Our cooked breakfasts use locally sourced and Fairtrade ingredients and feature homemade bread, potato cakes, pastries, preserves and muffins. The Warwick is under 90 minutes from London on the high-speed trains from St Pancras International and, once here, only a five-minute walk from some of the finest blue flag beaches in Kent. We're also a short distance from Dover and Folkstone and a train-change away from Ashford International (if you're travelling to the UK via EuroStar). We do not accept children under the age of 16. There are no parking restrictions on Warwick Road, but parking is on a first come, first served basis and can be busy, especially later in the evenings.
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Facilities Show/hide
- Main
- Hotel Non-Smoking Throughout, Tea/Coffee making facilities in each room, Hairdryer in each room
- Business
- Wi-Fi Available, Wi-Fi Available In Public Areas, Wi-Fi Available In Rooms
- In Room Entertainment
- TV, Radio
- Parking
- Car Parking Available Offsite
- Dining
- Breakfast to go
- Leisure
- [Channels] News, [Channels] Music, [Channels] Childrens
Can't find the facilities you're looking for?
- Call us on 0333 300 1007 and we'll help find the perfect hotel for you
- Call
Useful Info Show/hide
- Between 16:00 and 22:00
- By 11:00 hours
- Up to 1 years old
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- Pets are not allowed
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
100% would recommend it to a friend
Customer service
Food quality
Room quality
Great Stay
The Warwick Guesthouse was a lovely relaxing haven.
The homemade breakfast was to die for. Would definitely recommend to anyone....
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Very Good
A very pleasant one night stay, very hospitable and a lovely breakfast in the morning....


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it's not fabric bonded. the only shirt I saw that had the fabric bonding was from.. fuck, I can't remember, but you could tell.. you'd see the texture of the thread/fabrics on top of the leather. it's crazy.
post #85321 of 117666
1/29/13 at 1:38pm
Bows I must also say that I really like color on you.
Looks great and the shirt, which I can only imagine is quite heavy?, is very cool.
Toasty if you were serious about more plaid shirts, look at the Kitsune Worker flannel shirts.
They should have casted you as Jack Reacher in the new movie instead of Cruise, that way they wouldn't have had to stage the scene where he goes into a random thrift store and finds a perfect fitting leather-jacket


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iowa53 Review
Great Looking Comforter Set
This set looks really sharp on our new queen sized bed in the guest room. As others have noted, the yellow is more of a neon greenish yellow but looks very nice against the pale gray. Yes, the comforter is not reversible but of good quality and the bedskirt matches perfectly. I didn't really need so many accent pillows but they look great on the bed. I would recommend this set.
Was This Review Helpful?


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More Videos...
The One with Vaughn Gittin Jr. & the 2014 Ford Mustang! - World's Fastest Car Show Ep 3.27
Justin gets an all-access pass to the final round of the 2013 Formula Drift Championship. But first, Vaughn Gittin Jr takes him to the skid pad to see if an old dog can learn new tricks and forget everything he knew about racing fast. Justin starts the lesson in Vaughn's very own 2013 Ford Mustang RTR with the goal of finishing the day in Vaughn's actual Formula Drift Ford Mustang competion car. World's Fastest Car Show appears every Friday on the Motor Trend channel. http://www.youtube.com/motortrend Subscribe now to make sure you're in on all the action! http://www.youtube.com/subscription_center?add_user=motortrend Facebook - https://www.facebook.com/WorldsFastestCarShow, http://facebook.com/motortrendmag Twitter - http://twitter.com/motortrend & https://twitter.com/FastestCarShow Instagram - http://instagram.com/motortrend & http://instagram.com/worldsfastesttv Google+ - https://plus.google.com/1018679678590... Website - http://www.motortrend.com
Motorhome Mashup Part 2: Monster Go-Kart Challenge! - Dirt Every Day Ep. 28
On this episode of Dirt Every Day, Fred picks up the pieces after the destruction in the last episode. Now, the real chaos begins as Fred Williams attempts to take the frame of a 1986 Pace Arrow motorhome and transform it into a giant go-kart. Fred calls on the engineering assistance of his friend Frank and the Poly Goats Off Road Club to finish this big-block powered monster go cart. To test whether it stands up against the regular sized go-kart, they head out to the dirt for a head to head battle of wits, agility, and power. Tune in to see who comes out on top! Dirt Every Day appears every fourth Thursday on the Motor Trend channel. http://www.youtube.com/motortrend Subscribe now to make sure you're in on all the action! http://www.youtube.com/subscription_center?add_user=motortrend Facebook - http://facebook.com/motortrendmag & https://www.facebook.com/DirtEveryDay Twitter - http://twitter.com/motortrend Google+ - https://plus.google.com/1018679678590... Website - http://www.motortrend.com & http://www.4wheeloffroad.com/
2010 Mustang In Japan! - Drifting Ebisu Circuit
Vaughn Gittin Jr. continues his drifting tour of Japan with the 2010 Ford Mustang. Next stop, Ebisu Circuit.
ZR1 Vette vs Jet! - Chevrolet Corvette ZR1 Races A U.S. Navy Fighter Jet
MT Editor at Large Arthur St. Antoine pits Chevy's awesome "Blue Devil" -- the Corvette ZR1 -- against its toughest adversary yet: a Blue Angels F/A-18 Hornet fighter jet. Shot By: Jim Gleason & Terren Lin Edited By: Jim Gleason Read the story here: http://www.motortrend.com/features/performance/112_0908_chevy_corvette_zr1_ vs_fighter_jet_race/index.html


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Incredible Lady Liberty. Statue of Liberty, New York City Tablet (horizontal)
Digital art of Statue of Liberty in New York Harbor. Symbol of freedom for the United States of America and the entire world. She welcomes immigrants as they come in to America through Ellis Island.
Protect your tablet with an impact resistant hard shell case featuring an extremely slim profile. The lay-flat feature protects the front of your iPad by extending the bezel above the screen. Compatible with the Apple iPad Smart Cover. Great case offering solid protection and direct access to all device features.
Shipping is £3.99 globally on orders less than £30. Shipping is FREE for all orders over £30. Orders are delivered within 5-7 business days. If you have a query about delivery for a product which you have already ordered, please contact us.
If you don't absolutely love it, we'll take it back!
If you're not happy with your order, please contact us as soon as possible. In all cases we'll ask you to provide photographs of the item, including a close up of any tags/labels. To help us respond to you quickly, please include the order number in your message to us.
We have a money-back satisfaction guarantee, so whatever the problem, we're happy to work with you to fix it.
- Tags: act-of-congress, america-the-beautiful, american-museum-of-immigration, and-monuments-in-new-york-city, battery-park, central-park, dizinga-featured, empire-state-building, fineness, god-bless-america, goddess-of-democracy, government-of-new-york, gramercy-park, liberty-island, liberty-leading-the-people, liberty-park-manhattan, list-of-areas-in-the-united-states-national-park-system, list-of-buildings, list-of-world-heritage-sites-by-year-of-inscription, list-of-world-heritage-sites-in-the-americas, list-of-world-heritage-sites-in-the-united-states, lower-manhattan, national-emblem, national-historic-site-united-states, national-park-service, national-register-of-historic-places, other, sites, statue-of-liberty, united-states-bicentennial


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45-54 year old man treated with Facelift
Was this photo helpful? {{ voteCount + ' other' + (voteCountOthers == 1 ? '' : 's') }} found this helpful
A facelift, technically known as a rhytidectomy was performed on patient under general anesthesia without any complications in conjunction with upper and lower eyelid surgery.
By uploading this photo, Gilberto Montfort, MD has agreed with RealSelf.com policy that they've secured proper patient consent.


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Location: New York, United States
Member Since: August 2009
Open for read requests: Yes
Short Story / Young Adult
Short Story / Young Adult
Poem / Poetry
hey everyone!!! Im 21 yrs old :) finally legal. In college, my major is psychology.
I like to write, but i have a bad habit of not finishing my stuff.
Maybe some ppl could help me with that :)
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Home page
Welcome to the web site for the undergraduate course in Engineering. There is a separate site for the Manufacturing Engineering Tripos.
Site update September 2016
The menu system of the Teaching Office website was revamped last September, alongside some reorganisation of the content.
This is primarily to give us a much better control of where information is presented, and how it is presented. The change will also resolve a long-standing issue on mobile devices.
If you feel nostalgic (or lost), the old menu system will remain available for the time being on the following page:
If you encounter issues with the site, or if you are unable to access it, please contact:firstname.lastname@example.com
Last updated on 17/02/2017 12:25


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How about one of these too????
John B
--- In iris-photos@y..., "Jim Murrain" <jimmurrain@h...> wrote:
> I know it's a bit out of focus, 20-30 mph winds again today. But I
> seen so few pics of this rare sp. I thought it was worth posting. An
> flower is about the size of a quarter.
> Jim Murrain ,Kansas City, Mo. Zone 5/6
> Life member ,AIS , SIGNA &
> Greater Kansas City Iris Society
> Member, Pony Express Iris Society
> _________________________________________________________________
> Get your FREE download of MSN Explorer at http://explorer.msn.com
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ClubMom is the first free organization dedicated to rewarding and celebrating Moms! Join today - it's free - and get your chance to win
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|Found 1239 Recipes
|Revise this Search New Search
Hawaiian Wedding Pie MyBlessedEvent.comby shanni Aloha! Who wouldn't want a delectibly elegant Hawaiian Wedding Pie for..
Jenny's Mexican Chicken Soup (Crockpot Style)by jennyrosehealthcoach Similar to my guacamole recipe, I was following this Candida-friendly ..
Healthy Wheat-Crackerby KaelinMarie This recipe is very fun and also happens to be one of our healthy go-t..
Sunny Island Guacamoleby kissedbythesun Guacamole (or Guac) is a favorite among many people. In this guacamole..
Gougèresby nicolecatabran Gougères are baked savoury choux pastry, made from choux dough and mi..
Pan Seared Mahi-Mahi in Coconut-Serrano Broth, Roasted Banan..by tamaralittrell Recipe adapted from Stephen Pyles For the Island Cuisine Cooking Clas..
Nicole's Favourite Caramelised Shallots and Parmigiano Muffi..by nicolepingi Breakfast IS my favourite meal of the day. I could have breakfast al..
Peasto (pea pesto)by aleah Looking for a new pasta sauce? Try peasto (pea pesto)
Peach Tartby hawkteam FOODNETWORK.COM
Fresh tomato galetteby aleah A super easy fresh tomato galette, a perfect summer dish
No bake goat's cheese and roasted peppers cheesecakeby aleah A delicious, fresh, colourful and no bake savoury cheesecake, ideal fo..
Trahanoto with courgettes (zucchini) and ricottaby aleah Trahanoto is like a risotto, but different


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PT Astra International, Indonesia's financially beleaguered auto maker, is planning talks on debt restructuring this month with a committee to be set up by its creditors. Astra wants to reschedule payments on $726 million of debt that matures in 2006. Some $133 million is slated to come due in December, but the auto maker's president, Budi Setiadharma, says in reports that the company does not expect to be able to make the full payment. "We still don't know what the situation is for ...
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Minecraft Bukkit Server Plugin
This project received 5 bids from talented freelancers with an average bid price of £2087 GBP.Get free quotes for a project like this
Project Budget£250 - £750 GBP
Total Bids5
Project Description
I'm looking for a plugin that will record an entire session and save this as a file, which can then be injected back into MC and played back.
The user should be able to spectate from any of the players POV and also freely spectate as if they are an invisible character.
This would also require playback controls and the ability to record the invisible characters movements.
The cherry on top would be the ability to render this into a video.
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
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Directions: From Jct CR-284 (Main St) & Rt-23 (Hamburg Ave), SE 1.5 mi on Rt-23 to CR-565 (Glenwood Rd), E 3.5 mi on CR-565 to Tall Timbers Rd, N .6 mi on Tall Timbers to Gatehouse.
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Regression with Slowly Varying Regressors
Slowly varying regressors are asymptotically collinear in linear regression. Usual regression formulae for asymptotic standard errors remain valid but rates of convergence are affected and the limit distribution of the regression coefficients is shown to be one dimensional. Some asymptotic representations of partial sums of slowly varying functions and central limit theorems with slowly varying weights are given that assist in the development of a regression theory. Multivariate regression and polynomial regression with slowly varying functions are considered and shown to be equivalent, up to standardization, to regression on a polynomial in a logarithmic trend. The theory involves second, third and higher order forms of slow variation. Some applications to trend regression are discussed.
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|45 pages
|Date of creation:
|Jul 2001
|Contact details of provider:
| Postal: Yale University, Box 208281, New Haven, CT 06520-8281 USA
Phone: (203) 432-3702
Fax: (203) 432-6167
Web page: http://cowles.yale.edu/
More information through EDIRC
|Order Information:
| Postal: Cowles Foundation, Yale University, Box 208281, New Haven, CT 06520-8281 USA
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"I want to talk today about two big themes that will be repeated frequently this week – the ways that colleagues are using technology, both enterprise-wide technology and social media, to enhance & maximize learning. And I'm going to touch on the ways institutions are using technology to maximize their work. We see both of these trends every day on the web, in newspapers, at conferences, and on our campuses."


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Apparently, no one calls New Orleans "K-Ville." Creator Jonathan Lisco says the title of FOX's upcoming series (shown by the newly launched E! in Canada) was inspired by some graffiti scribbled post-hurricane, graffiti that appears in the pilot's opening sequence. Those glimpses into a city rebuilding after disaster signal how much the new New Orleans is a character in this new cop show.
That tidbit comes from an article Bill Carter of the New York Times wrote about the show's economic impact on a city that so desperately needs to rebuild an economy.
Is it a faithful portrayal? Of course not. It's a TV show. But its aftermath-of-Katrina backdrop gives the show's atmosphere a poignancy and depth that the scripts don't quite deserve yet. K-Ville's pilot includes flashback scenes from the hurricane, showing our central characters in the thick of it, and the present-day central case of what's ultimately a straight procedural springs squarely out of issues in post-Katrina New Orleans.
Now that I've been converted, I'm going to be one of those insufferable people comparing anything that smells like a cop show with a purpose to The Wire, which is nominally a cop show, too, also set in a city spilling over with untapped-on-TV vistas, also exploring a city and its people. But The Wire is a searing look at the guts of a city and, by proxy, the issues of a country. K-Ville is not that, not yet, though it seems to be striving for something similar, giving it the potential to be something more than a conventional cop show in an unconventional setting.
Still, HBO's The Wire, soaked in hopelessness and despair, barely making a dent in the television viewing landscape, is hardly the model to emulate to attract large numbers of viewers. The network-broadcast K-Ville is wisely going with an air of optimism.
Marlin Boulet (Anthony Anderson) is the show's moral centre – with some immoral tendencies, like beating up suspects who, oops, turn out to be innocent. He's a cop torn between loyalty to his family, a wife and daughter who fled to Atlanta and are reluctant to return to the Upper 9th ward, and to the city he loves and has vowed to serve and protect. As he says when neighbours put up For Sale signs and his wife implores him to leave New Orleans with her, it can't be rebuilt if no one will fight for it. Boulet even provides the show its stab at symbolism, defending the few cypress tress left after the salt from the storm destroyed the once-ubiquitous trees. He makes me hope K-Ville will be about the struggle to reclaim a city from crime and despair and disaster, instead of just another excuse for a cop show.
Anderson in particular brings his character to life, but he's been given the advantage of having the only character given much to do in the pilot episode, and with copious amounts of motivation for his actions. He appears to be the bad cop to Cole Hauser's good cop, Trevor Cobb, the mysterious, by-the-books partner from Cincinnati who has arrived at the New Orleans Police Department after a stint in Afghanistan and seems to know the city a little too well. He becomes far less mysterious by the end of the pilot, but like much of the plot here, the mystery dissipates with a credibility-stretching revelation.
So far the supporting characters are nonentities, so it seems the show will live or die on how quickly it can make us care about the uneasy detente between its two leads, and how it can explore cases in its unique setting without relying on the setting itself to do the heavy lifting.
It could also use a better-defined sense of humour. It's not completely humourless, but it aims for the usual cop bluster we've seen a million times before, usually better. For example, there's a dig at the forensic magic of CSIs not being available to them –- and, as a bonus, it's also a dig at CSI — a joke that's not quite funny, not quite making a point. The Wire did the whole underfunded police department thing a lot more subtly and powerfully. And CSI is a lot slicker in the procedural arena. And Bones has a sharper sense of humour.
K-Ville has a powerful setting, and solid leads, and the potential to explore issues people care about. But on the basis of the pilot episode, it needs stories that rise to the level of its backdrop in order to really connect with viewers.
Catch the debut of K-Ville Monday, September 17 at 9 p.m. on FOX, or E! in Canada.Powered by Sidelines


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Recent News and Things to Do in Katy, TX
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Thanks for visiting Katy Christian Magazine. KatyChristianMagazine.com is your go to source for news, information, and things to do in Katy, TX and the greater West Houston area. Stay up-to-date with the latest news and information, view our online magazine, or use our business directory to find locate Katy-area attorneys, schools, and area businesses. We follow the stories that you are interested in.
Katy Christian Magazine is published six times per year and can be picked up for free at over a hundred businesses, churches, and other locations across Katy and West Houston. In each issue, we feature local Katy area Christian businesses, churches, and organizations that are making a difference right here in Katy.


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text:
IMDB Rating: N/A
Release Date: 04 May 2016
Genre: Drama
Runtime: N/A
Actor : Nikolaj Groth, Clara Rosager, Lukas Løkken, Laura Bach
Writers : Thorvald Lervad
Director : Barbara Topsøe-Rothenborg
Language : Danish
Country : Denmark
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The thing you're missing, possibly, is that Canada is growing ever more virulently antisemitic (or Jew-hating, to be precise). Synagogue burnings and cemetary desecrations have to date occurred in 4 of the 10 provinces. That jab at Asper is the Canadian version of the "Zionist conspiracy"; the only possible reason for a newspaper supporting Israel's right to exist is of course if it belongs to the worldwide conspiracy of evil plotting Jews who are simultaneously controlling the banks and sponsoring the evils of Communism.
And the reason why so many Americans have favourable opinions about Canada? They don't know how hostile, mediocre and irritating we are. You're helping to change that, and it is my fond hope that this will eventually change us. Keep it up.
Helps explain this interesting email (titled "Why the Israelis are always crying"):
You people have the knack of pissing off the rest of the world without even trying. Maybe you should take a good look at yourselves and see why they predicted that Jews would be persecuted for 2000 years. It's what you guys do. I bought a house from one and understand it fully. You can't help it, you just are a bunch of unlikable people who try to screw everyone with whom you come in contact. Well, that's fine, keep saying "we're offended" which is what the rest of the world has been saying about your for centuries. Thank your God for the American armament!
Though, to be fair, I've found little evidence of anti-Semitism among the Canadian hate-mailers except of the variety usually found in some of our own lefty anti-war quarters.


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My bf and I came out and stayed in the lofthaven and did the romantic package. The zip line tour lasted about 2 hours and was so much fun! And dinner at the J5 was a 5 course... read more
Join us at Cypress Valley Canopy Tours for a thrilling eco-adventure, where...
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Team Valor International's State of Play,
winner of the With Anticipation (G2) last September at Saratoga, heads a
field of seven 3-year-olds entered Tuesday for the 24th running of the
$100,000 Transylvania (G3) at 1 1/16 miles on the turf Friday.
Transylvania serves as the feature race on the opening day of the
15-day Spring Meet that runs through April 27. Friday's 10-race card
begins at 1:05 p.m. (ET) with the Transylvania carded as the ninth race
with a 5:13 p.m. post time.
by Graham Motion, State of Play won the John Battaglia Memorial at
Turfway Park on March 3 in his most recent start. John Velazquez has the
mount on State of Play, who will break from post position one and carry
123 pounds.
Another colt that figures to attract interest Friday in the Transylvania is Fletcher and Carolyn Gray's Icon Ike.
Trained by Larry Jones, Icon Ike is undefeated in three starts on the
grass and in his most recent start won the Black Gold at Fair Grounds in
which he defeated Hero of Order, who came back to win Sunday's Louisiana Derby (G2).
Miguel Mena has the mount on Icon Ike, who will break from post position seven and carry 118 pounds.
The field for the Transylvania, from the inside out, is as follows: State of Play (Velazquez, 123 pounds), Wayward Sailor (Alan Garcia, 118), Travel Advisory (Manny Cruz, 118), Saturday Launch (Jesus Castanon, 118), Monastic (Julien Leparoux, 118), Silver Max (Robby Albarado, 118) and Icon Ike (Mena, 118).
There are only 80 days to go until Kentucky D...
Johnny Hop, a 3-year-old son of Bodemeister who so...
Irish War Cry joined the 2017 Kentucky Derby trail...
Saturday's $250,000, Grade 3 Sam F. Davis Stakes b...
Dual classic winner and 1999 Horse of the Year&nbs...
Multiple Grade 1 winner Practical Joke breezed fiv...
Stonestreet Stables, LLC's Terra Promessa improved...
This year's Kentucky Derby is still a few months o...
President's Day brings an outstanding card of raci...
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Join 53,536
other passionate horse racing fans!


text:
"The Caribbean in the Mediterranean" is what its creators envisaged. A complex of whitewashed bungalows and low-rise hotels scattered around 60 acres of luxuriant banana trees, hibiscus and other sub-tropical shrubs under a shady canopy of pine and palm trees.
There's a choice of six hotels on the site, but the best bet for families are the Forte Hotel Village Bungalows. You get your own whitewashed apartment, which comes complete with a terrace and a patch of garden, but you also get the same service as if you were in a hotel.
A choice of 15 restaurants, some (but not all) to which you have free access as part of a half-board deal. Most popular with children, is Buffalo Bill, with special kids' menus and low-level tables and chairs.
>Brick paths twist through the resort, leading down to a long beach that shelves gently into the sea.
Numerous swimming pools, some with waterslides. The full gamut of water sports, plus tennis and putting. There is also a daily children's club, a miniature zoo and an adventure playground.
Out and About
The ethos tends to be to keep guests on site. However, if you do escape, there are spectacular Roman ruins on the nearby Nora headland. Within an hour, you can drive to the Giara de Gesturi swamps to look for moufflons and the wild ponies that gallop through the shallows.
Sample Prices
Seven nights half-board with Magic of Italy (0181-533 8888) costs £829 per person for four people in a two-bedroom apartment (50 per cent reduction for children).
Forte Village Resort, 09010 S, Margherita di Pula, Cagliari, Italy. From the UK, call: (freephone) 0800 317 0066.Reuse content


text:
This note just came in with $1,975.00 for National Review Online's fall fundraising drive:
I am matching the contributions made by the generous and supportive folks referenced in:
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2013 hyundai veloster turbo vs mercedes benz c250 Enjoy the video! Post up if you have any questions or comments. Like this video and subscribe for more videos! ╔═╦╗╔╦╗╔═╦═╦╦╦╦╗╔═╗ ║╚╣║║║╚╣╚╣╔╣╔╣║╚╣═╣ ╠╗║╚╝║║╠╗║╚╣║║║║║═╣ ╚═╩══╩═╩═╩═╩╝╚╩═╩═╝ TAGS TAGS++++ WATH THIS plummer speedway on the 818 sfv street racing sunday meets 818 racing vtec honda civic si b20 swap vs honda civic hatchback h22 swap, gt, se r, saticoy speedway san fernando valley meets illegal race no turbo ford Mustang gt vs nissan altima se r vs honda accord v6 vtec bone stock gt Nora The Piano Cat: The Sequel - Better than the original! how to get iphone 5 camera test 1,000 views on youtube in one day zr1 corvette frs sti gt86 subaru scion toyota gtr r35 ams alpha 2012 2013 drag racing times muscle cars sti cops lapd la street racers comptom reseda canoga speedway sfv cali gtr k20 k24 b16 b18 b20 vtec si type r type s acura integra eg eh ef em1 em2 j30 j32 Camaro ss z28 trans am cobra gt500 shelby zr1 z06 ae86 hachiroki trueno 240sx fd fc rx7 rx3 2014 2015 2012 2013 models high way chase bbjm1 drag times info mile run nissan toyota mazda Mustang ford chevy silverado ram dodge srt8 srt 5.0 celica all trac supra movie turbo from hell vs lambo ferrari alpha gtr gtr35 rx8 civic turbo facebook myspace youtube twiter genesis corvette cbr 600 900 1000 hybusa susuki motors top secret cpr tuxfor 210 fwy sylmar gleanoaks plummer lil canoga budwaiser trs818cali videos accord vtec helaflush civic persuit chase 101 fwy test drive pontiac 2012 2013 toyota camry se v6 car and drive sony apple iphone 5 5s 6 ipad ipod jailbreak unlocked new version 200mph motorcycle best driver in the world best save dragway speedway trac princess big burnout wrx evo x mitsubishi subaru rs500 ford focus frs brz gt86 scion sport mode paddle shifters how to drive stick shift or manual dmv c63 cl600 amg mercedes benz bmw 335i 323i 328i 535i m6 m3 m1 fiat 500 turbo vw jetta altima se r nismo niggas police chase LA texas high way street race gt40 r8 ek ws20 350z 280z 370z gt2000 gt3000 twin turbo car cold air intake mufflers greedy Exhaust imports vs muscle 1/4 mile speed 340hp vs 289hp vs 265hp vtec bmw 335i vs cobra Supercharger
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