text:
Wednesday, January 15, 2014
QD: News Every Day-- One-third of doctors overuse MRIs for breast cancer screening
More than a third of physicians reported offering MRIs and other breast cancer screening tests that exceeded guidelines for a low-risk 51-year-old woman, a study found.
Guidelines from the U.S. Preventive Services Task Force, the American College of Obstetrics and Gynecology and the American Cancer Society recommend mammography as the only routine screening test for women 50 years and older and who are not at high risk of breast cancer. MRI can be used as an adjunct to mammography for women who face a 20% or greater lifetime risk.
Researchers analyzed 553 family physicians, general internists, and obstetrician-gynecologists who practiced in offices or hospitals. The physicians had completed a survey that presented a vignette of a health maintenance visit for an asymptomatic 51-year-old woman who was not at high risk for breast cancer. The vignettes were randomized to vary the woman's race, insurance, family history of cancer and request for ovarian cancer screening.
Results appeared in the January issue of the Journal of General Internal Medicine.
In the study, 36% (95 % CI, 31.8 % to 40.5 %) of physicians reported offering breast cancer screening tests that were inconsistent with guidelines, with most offering MRI and/or ultrasound (33.2 %; 95 % CI, 29.1 % to 37.6 %). Adjusted analysis revealed that risk-averse physicians and those who believed in the clinical effectiveness of MRI were more likely to offer extra breast cancer screening.
The researchers noted that one-fifth of women ages 50 to 74 have not received age-appropriate breast cancer screening at all, and they suggested strategies, such as academic detailing and computerized clinical decision support, to decrease overuse of resources.
The authors wrote, "These extra breast cancer screening tests are particularly concerning as there is no evidence of their efficacy for routine screening, and rising U.S. health care costs are, in part, due to the purchase and use of medical technologies."
Labels: breast cancer, guidelines, less is more, mammography, MRIs, QD, women's health
0 Comments:
Subscribe to Post Comments [Atom]
This is a printer-friendly version of this page
Contact ACP Internist
Send comments to ACP Internist staff at firstname.lastname@example.com.
Previous Posts
- Physician Fee Schedule 2014 uses frequent flier mo...
- What patients don't know about Obamacare might hel...
- The ideal hospital rounding model
- QD: News Every Day--Brain training finds way to ke...
- Happy New Year!
- The beginning of the end for chlorhexidine?
- QD: News Every Day--Flu activity high as cases spr...
- Medical care in Old Fangak, South Sudan
- Evaluating physician performance
- Retainer medicine as a potential primary care solu...
Blog log
Members of the American College of Physicians contribute posts from their own sites to ACP Internistand ACP Hospitalist. Contributors include:
Albert Fuchs,
Albert Fuchs, MD, FACP, graduated from the University of California, Los Angeles School of Medicine, where he also did his internal medicine training. Certified by the American Board of Internal Medicine, Dr. Fuchs spent three years as a full-time faculty member at UCLA School of Medicine before opening his private practice in Beverly Hills in 2000.
And Thus, It Begins
Amanda Xi, ACP Medical Student Member, is a first-year medical student at the OUWB School of Medicine, charter class of 2015, in Rochester, Mich., from which she which chronicles her journey through medical training from day 1 of medical school.
Ira S. Nash, MD, FACP, is the senior vice president and executive director of the North Shore-LIJ Medical Group, and a professor of Cardiology and Population Health at Hofstra North Shore-LIJ School of Medicine. He is Board Certified in Internal Medicine and Cardiovascular Diseases and was in the private practice of cardiology before joining the full-time faculty of Massachusetts General Hospital.
Zackary Berger
Zackary Berger, MD, ACP Member, is a primary care doctor and general internist in the Division of General Internal Medicine at Johns Hopkins. His research interests include doctor-patient communication, bioethics, and systematic reviews.
Controversies in Hospital
Infection Prevention
Run by three ACP Fellows, this blog ponders vexing issues in infection prevention and control, inside and outside the hospital. Daniel J Diekema, MD, FACP, practices infectious diseases, clinical microbiology, and hospital epidemiology in Iowa City, Iowa, splitting time between seeing patients with infectious diseases, diagnosing infections in the microbiology laboratory, and trying to prevent infections in the hospital. Michael B. Edmond, MD, FACP, is a hospital epidemiologist in Iowa City, IA, with a focus on understanding why infections occur in the hospital and ways to prevent these infections, and sees patients in the inpatient and outpatient settings. Eli N. Perencevich, MD, ACP Member, is an infectious disease physician and epidemiologist in Iowa City, Iowa, who studies methods to halt the spread of resistant bacteria in our hospitals (including novel ways to get everyone to wash their hands).
db's Medical Rants
Robert M. Centor, MD, FACP, contributes short essays contemplating medicine and the health care system.
Suneel Dhand, MD, ACP Member
Suneel Dhand, MD, ACP Member, is a practicing physician in Massachusetts. He has published numerous articles in clinical medicine, covering a wide range of specialty areas including; pulmonology, cardiology, endocrinology, hematology, and infectious disease. He has also authored chapters in the prestigious "5-Minute Clinical Consult" medical textbook. His other clinical interests include quality improvement, hospital safety, hospital utilization, and the use of technology in health care.
Juliet K. Mavromatis, MD, FACP, provides a conversation about health topics for patients and health professionals.
Dr. Mintz' Blog
Matthew Mintz, MD, FACP, has practiced internal medicine for more than a decade and is an Associate Professor of Medicine at an academic medical center on the East Coast. His time is split between teaching medical students and residents, and caring for patients.
Toni Brayer, MD, FACP, blogs about the rapid changes in science, medicine, health and healing in the 21st century.
Vineet Arora, MD, FACP, is Associate Program Director for the Internal Medicine Residency and Assistant Dean of Scholarship & Discovery at the Pritzker School of Medicine for the University of Chicago. Her education and research focus is on resident duty hours, patient handoffs, medical professionalism, and quality of hospital care. She is also an academic hospitalist.
Glass Hospital
John H. Schumann, MD, FACP, provides transparency on the workings of medical practice and the complexities of hospital care, illuminates the emotional and cognitive aspects of caregiving and decision-making from the perspective of an active primary care physician, and offers behind-the-scenes portraits of hospital sanctums and the people who inhabit them.
Gut Check
Ryan Madanick, MD, ACP Member, is a gastroenterologist at the University of North Carolina School of Medicine, and the Program Director for the GI & Hepatology Fellowship Program. He specializes in diseases of the esophagus, with a strong interest in the diagnosis and treatment of patients who have difficult-to-manage esophageal problems such as refractory GERD, heartburn, and chest pain.
I'm dok
Mike Aref, MD, PhD, FACP, is an academic hospitalist with an interest in basic and clinical science and education, with interests in noninvasive monitoring and diagnostic testing using novel bedside imaging modalities, diagnostic reasoning, medical informatics, new medical education modalities, pre-code/code management, palliative care, patient-physician communication, quality improvement, and quantitative biomedical imaging.
William Hersh, MD, FACP, Professor and Chair, Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, posts his thoughts on various topics related to biomedical and health informatics.
David Katz, MD
David L. Katz, MD, MPH, FACP, is an internationally renowned authority on nutrition, weight management, and the prevention of chronic disease, and an internationally recognized leader in integrative medicine and patient-centered care.
Just Oncology
Richard Just, MD, ACP Member, has 36 years in clinical practice of hematology and medical oncology. His blog is a joint publication with Gregg Masters, MPH.
Kevin Pho, MD, ACP Member, offers one of the Web's definitive sites for influential health commentary.
Michael Kirsch, MD, FACP, addresses the joys and challenges of medical practice, including controversies in the doctor-patient relationship, medical ethics and measuring medical quality. When he's not writing, he's performing colonoscopies.
Medical Lessons
Elaine Schattner, MD, FACP, shares her ideas on education, ethics in medicine, health care news and culture. Her views on medicine are informed by her past experiences in caring for patients, as a researcher in cancer immunology, and as a patient who's had breast cancer.
Mired in MedEd
Alexander M. Djuricich, MD, FACP, is the Associate Dean for Continuing Medical Education (CME), and a Program Director in Medicine-Pediatrics at the Indiana University School of Medicine in Indianapolis, where he blogs about medical education.
More Musings
Rob Lamberts, MD, ACP Member, a med-peds and general practice internist, returns with "volume 2" of his personal musings about medicine, life, armadillos and Sasquatch at More Musings (of a Distractible Kind).
David M. Sack, MD, FACP, practices general gastroenterology at a small community hospital in Connecticut. His blog is a series of musings on medicine, medical care, the health care system and medical ethics, in no particular order.
Reflections of a Grady
Kimberly Manning, MD, FACP, reflects on the personal side of being a doctor in a community hospital in Atlanta.
The Blog of Paul Sufka
Paul Sufka, MD, ACP Member, is a board certified rheumatologist in St. Paul, Minn. He was a chief resident in internal medicine with the University of Minnesota and then completed his fellowship training in rheumatology in June 2011 at the University of Minnesota Department of Rheumatology. His interests include the use of technology in medicine.
Technology in (Medical)
Neil Mehta, MBBS, MS, FACP, is interested in use of technology in education, social media and networking, practice management and evidence-based medicine tools, personal information and knowledge management.
Peter A. Lipson,
Peter A. Lipson, MD, ACP Member, is a practicing internist and teaching physician in Southeast Michigan. The blog, which has been around in various forms since 2007, offers musings on the intersection of science, medicine, and culture.
Why is American Health Care So Expensive?
Janice Boughton, MD, FACP, practiced internal medicine for 20 years before adopting a career in hospital and primary care medicine as a locum tenens physician. She lives in Idaho when not traveling.
World's Best Site
Daniel Ginsberg, MD, FACP, is an internal medicine physician who has avidly applied computers to medicine since 1986, when he first wrote medically oriented computer programs. He is in practice in Tacoma, Washington.
Other blogs of note:
American Journal of
Also known as the Green Journal, the American Journal of Medicine publishes original clinical articles of interest to physicians in internal medicine and its subspecialities, both in academia and community-based practice.
A collaborative medical blog started by Neil Shapiro, MD, ACP Member, associate program director at New York University Medical Center's internal medicine residency program. Faculty, residents and students contribute case studies, mystery quizzes, news, commentary and more.
Interact MD
Michael Benjamin, MD, ACP member, doesn't accept industry money so he can create an independent, clinician-reviewed space on the Internet for physicians to report and comment on the medical news of the day.
PLoS Blog
The Public Library of Science's open access materials include a blog.
White Coat
One of the most popular anonymous blogs written by an emergency room physician.


text:
by Duncan Larkin, Published May. 15, 2013, Updated May. 15, 2013 at 10:33 AM UTC
Over $1 million has been raised in four years.
Start your FREE subscription to Competitor Digital today!
Get our monthly digital magazine, weekly running content & exclusive offers delivered to your inbox.
© 2014 Competitor Group Inc. All Rights Reserved

subset: commoncrawl


text:
Wendy Ruopp's Blog
A blender can be your best friend for a quick summer supper. I mean, I'll have to make sure the margarita mix is all gone and give it a quick rinse… But then in goes tomatoes, cucumber, bell pepper, a clove of garlic, some good white sandwich bread, oil and vinegar—and out comes gazpacho. It's so easy! I can blend up a batch in the morning and let it chill all day, then spend a few minutes in the evening making crispy, herby croutons to garnish bowls (or margarita glasses) of health-packed, song-of-summer, refreshing cool soup for supper.
This chilled soup—made with fleshy chunks of ripe tomatoes, cucumbers crisper than a cold hilltop morning and topped with cubes of crusty bread—can refresh even the hottest August days. That's one reason the Spaniards and Portuguese developed this regional classic. They blend the garden's best with garlic, vinegar...read full post »
TAGS: Food Blog, Budget meals, Dinner, Entertaining, Quick meals, Wendy Ruopp
When the EatingWell Test Kitchen started talking about the "flautas" they were making, I admit I needed a translation. But when I tasted Oven-Fried Beef Taquitos, I knew just what they were: deliciously crispy rolled-up little tacos filled with beef—and a healthy surprise.
Taquitos are a standard item on fast-food menus. Typically they're deep-fried and can be greasy, rolled up in calories and fat. It's not hard to understand why they'd be popular. We've kept that crispy goodness, but our version is baked and so much better for you. We use lean ground beef for the filling and a whole zucchini, shredded and mixed in with the spices so its presence is subtle (some might say sneaky). Top it with some yummy sharp...read full post »
My family hosts an Oscar party every year—even in northern Vermont about as far away from Hollywood as we could be, we're starstruck and red-carpet ready. We like to serve nominee-related food and drink (we don't go full Wolfgang Puck, but we have our moments). The Oscars 2016 nominees are a challenging bunch, edibly speaking, but we'll do our best to recognize the potential winners in pun form while still serving delicious party food. Here are some menu ideas, featuring some favorite EatingWell recipes renamed for the occasion:
We'll offer a dry Martian (martini) and a couple celebrity cocktails:...read full post »
TAGS: Food Blog, Wendy Ruopp
In its classic form, chicken parm (short for Parmesan, but of course you knew that) is a dish you order at a family-style Italian restaurant when you want a big piece of chicken breast fried, coated in buttery, cheesy breadcrumbs, topped with melted mozzarella and served with a pile of pasta and tomato sauce and a solid dusting of Parmesan cheese. To replicate this dish at home, you'd go through the process of dredging and breading the chicken breasts, then getting them crispy and golden in a frying pan with plenty of oil, followed by baking them in the oven topped with gooey cheese—not to mention the homemade sauce. So delicious. So much work.
Want to enjoy this favorite dinner at home for a fraction of the effort (and calories)? EatingWell's genius recipe makeover of chicken Parmesan (pictured above) gives you all that Italian-...read full post »
The scene: My kitchen. The time: Tonight, about 30 minutes before everyone melts down from starvation. The options: Join in the meltdown; scrounge around for enough money to order pizza; or do something special with those innocent-looking potatoes in the pantry. I bought them recently, thinking it would be a good idea to have potatoes in the house, just in case. And in this case, I can turn them into Asparagus & Ham Stuffed Potatoes in 30 minutes and turn dinner drama into a satisfying family meal. (At less than $3 per serving, it's cheaper than pizza too.)
Don't Miss: Loaded Twice-Baked Potatoes and More Healthy Baked Potato Recipes
The potatoes are easily cooked in the microwave while you organize the "stuff" to stuff them...read full post »


text:
< Prev 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Next >
LesleyPro_04 Reveals His Desire to Eat Tiffany on 6/2/2015, submitted by Avalanche
<Tiffany> i'll taste delicious in a minute
<LesleyPro_04> Yep, had a hunch it would be delicious :D
No bullying on 3/7/2014, submitted by Mojo
* AndyMurray (email@example.com) has joined #neoseeker
<AndyMurray> hi fuckers
<Whelan> ite
<DarkWave> hi
<DarkWave> we were just talking about indians...
[ read full quote... ]
Aki = Still Master Grower on 24/12/2013, submitted by Dynamite
<Tiffany> hi aki
<Tiffany> grown anything nice for your wife for xmas?
<Tiffany> toothpaste, beer, etc
<aki-ipad> My dick
He Fucked Those Wood Chips Up on 22/11/2013, submitted by Dynamite
<Tiffany> he's set fire to wood chip mountain
<Tiffany> in pure fit of RAGE
<CFB> why are you always talking about wood chips, do you fantasize about them or something? I haven't had woodchips to deal with in over 2 years
<Torm> he fucked those woodchips up
<Torm> they ain't comin back...
[ read full quote... ]
CFB admits his true colours on 6/8/2013, submitted by Jambo
[03:20:54] <AndyMurray> be a man
[03:21:41] <CFB> i'm not
Tek you Retard on 5/7/2013, submitted by Jambo
<CaFB> and i'm still posting on 99.9% of the other sites i'm on
<AndyMurray> you cried because all the otheres were unbanned apart from you
<AndyMurray> and you post on 1000 websites?
<AndyMurray> well 999 now
<CaFB> no i didn't...
[ read full quote... ]
Stitch speaks on sex on 27/6/2013, submitted by Shin
<Stitch> But it can also be troublish, during moments when you have to relie on your partner to help you.
<Stitch> I once almost shoot out my ammo, because it took longer for my partner to get me over to the other side, while a giant monster was attacking me.
balls, penis on 7/6/2013, submitted by Mojo
<CFB> jambo it's a guy cat you tit
<AndyMurray> lol what?
<CFB> balls, penis does that mean anything to you
<AndyMurray> haha wtf are you on about
<CFB> <AndyMurray> is your cat dead yet CFB?...
[ read full quote... ]
Avalanche Loves Jambo's Pearl Necklace on 22/5/2013, submitted by Dynamite
<Avalanche> with money, you can buy oysters mmmmmmmmmmmm :>
<AndyMurray> ewww
<AndyMurray> id give you a pearl necklace though
<AndyMurray> hi
<Avalanche> yum, i'll eat those too...
[ read full quote... ]
You're an idit on 12/5/2013, submitted by Dynamite
<CaFB> you're in an idit
CFB = Door Beater on 27/4/2013, submitted by Dynamite
<AndyMurray> CFB is seething
<Tiffany> prob throwing stuff around his room again
<CFB> i'm not aki
<Tiffany> punched another hole in his wall/door
<CFB> i tried once for fun, my door is pretty sturdy. Good material :P...
[ read full quote... ]
Stitch's Art: CFB IRL on 16/3/2013, submitted by Dynamite
<Stitch> <Tiffany> Rainbow_Dash, draw cfb plz
<Stitch> http://i.imgur.com/Rq9KLz9.png
<Stitch> Here ya go. :P
CFB Convinces Himself on 15/3/2013, submitted by Jambo
<CFB> losing weight means losing fat. You can't lose weight and still be fat it's not how it works
Dinner = Supper on 14/3/2013, submitted by Dynamite
<CFB> supper and dinner are the same thing moron
Avalith = Popeye on 8/3/2013, submitted by Dynamite
<Tiffany> it's avalith the sailor man, he lives in a garbage can
<Tiffany> he turned on the gas and burned off his unibrow
<Tiffany> it's avalith the sailor man!
* Tiffany takes a bow
<Avalith> what
Dynamite offers her services for CFB on 6/3/2013, submitted by tekmosis
<Tiffany> hi noobs
<Tiffany> moved away from my desk
<Tiffany> BUT DON'T WORRY
<Tiffany> i can still chat 2 u
<tekmosis> moved to your bed so you can get ...
[ read full quote... ]
CFB - Born with 70s Porno Tash on 27/2/2013, submitted by Dynamite
<CFB> fyi that tache as you called it back then was around since I was born, i've since shaved it off like 15 times since then
wow, cfb owned tiff on 20/2/2013, submitted by Chaos
<Avalith> Tiffany: when are you gonna get your
hormones back in balance?
<Avalith> it's painful watching you struggle with
your gender identity crisis
<Tiffany> almost as painful as watching you try to ...
[ read full quote... ]
RAGE QUIT on 9/2/2013, submitted by Chaos
[00:37] <CFB> but when it comes to certain stuff
I have a very sharp memory
[00:38] <Avalith> like tiffany
[00:38] <Avalith> hi
[00:38] <CFB> no tiff is just material used on toys...
[ read full quote... ]
Jambo's Fake New Job on 7/2/2013, submitted by Mojo
<Mojo> AndyMurray: get a job
<Mojo> you're just trolling chat 24/7 now
<Mojo> new job
<AndyMurray> iv actually got a new job :)
<AndyMurray> start a week on monday...
[ read full quote... ]
E=MCdonald's on 7/1/2013, submitted by Mojo
<Tiffany> is cfb's autism flaring up again?
<Tiffany> and
<Tiffany> how does it feel to be in the league with people like AR, Deis and Spud
<CFB> we've already established i'm not autistic
<CFB> you on the other hand is a different story...
[ read full quote... ]
Didn't Think So on 19/11/2012, submitted by Dynamite
<@Mojo> !kick NeoServ
* NeoServ has kicked Mojo from #neoseeker (Oops!)
There's Hope for Us All on 2/11/2012, submitted by Dynamite
<Aki> Shutup you virgin nerds... (Don't worry I was like you too for ages)
Penis on 12/4/2012, submitted by tekmosis
* Quits: Whelan (email@example.com)
<tekmosis> watch, if you say penis, whelan will come back
<tekmosis> PENIS
* Joins: Whelan (~email@example.com)
Dyno Rage on 8/4/2012, submitted by Chaos
< Nick> one thing that cfb and dyna have in common, they take what they can get
< Unknown_Warrior> and live on their parents' money
-!- mode/#neoseeker [+b *!*@pwnsu-uhqin5.access.telenet.be] by NeoServ
-!- Unknown_Warrior was kicked from #neoseeker by NeoServ [Requested by Operator - Ban Duration: 10m]
Registered users can submit quotes to be added the IRCpwnsu database.
You must first log in above before attempting to submit a quote. Close me.


text:
Invaluable cannot guarantee the accuracy of translations through Google Translate and disclaims any responsibility for inaccurate translations.
Show translation options
Lot 515: Paper Money - Germany 10 Mark 1944
Portuguese Former colonies & world banknotes, Books & Medals
by Numismatica Leiloes
November 4, 2016
Lisboa, PortugalLive Auction
Past Lot
Looking for the realized and estimated price?
Paper Money - Germany 10 Mark 1944
PAPEL. 10 Mark 1944. 011747600. Vincos. 11,1x6,6 cm. P 194b.
Browse more items


text:
Carlsbad Seapointe Resort
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Suites
- Wireless internet connection in public areas
- Refrigerator in room
- Microwave in room
- Swimming pool
- High-speed internet in room
Photos of Carlsbad Seapointe Resort
Travelers also looked at:
- More recommendations
- Swimming pool
- Beach
- Fitness/Health center
- Wireless internet connection in room (surcharge)
- Wireless internet connection in public areas
- Refrigerator in room
- Microwave in room
- High-speed internet in room
- Wheelchair accessibility
- Air-Conditioning
- Kitchenette
- Suites
- All-Suites Property
- Business Services
- Kids activities or Babysitting
TripAdvisor Reviews Carlsbad Seapointe Resort
Travel Blogs from Carlsbad
Goodbye Harvey
... You traveled across the US to me, and shepharded Zach and I to Burning Man and back. I sold you to CarMax. I'm sorry we chose Ravina over you. But they'll fix you up, paint you a more hip color, and I hope you find a good new home. Fair well, my friend.
Western States of Mind: Part One
... gas cost me $3.47 per gallon. As the lady in the gas station told me, "We live paycheck to paycheck in California." As with Texas, there is no way to cover the tremendous diversity and dynamics of California in this entry, so maybe down the road, California can be more thoroughly addressed. Although not surfing or catching a few rays on the beach, from ...
Crossing USA - Part 2
... ago.. The fit one's did a FAST morning walk - me almost running with the fast pace set by Gene (I had forgotten he had done marathons, walking in the past) and he set a cracking pace. I enjoyed seeing the different type of gardening,( as I struggled to keep up) - no lawns but 'anything' grows in the desert, as long as it is watered, and the private gardens were beautiful. Another Mexican meal for ...
The Final Wrap-Up
... as a PT student. I, of course, rambled on about bike and build for a bit before my 2 best friends from high school, Marissa and Christina, came to say their goodbyes. You'd think I'd be getting really good at goodbyes by this point, but this one was again a toughie. At least they promised they'd come visit me real soon! After they left, I finished up some stuff for financial aid before hitting the sack around 130a, just in time to squeeze in about 4 hours of sleep before it was ...
Photo Album: Bitterballen!
Photo Album: Bitterballen!
On my last day we decided to do what we had been talking about for days: make bitterballen! When Angie came to visit me seven years ago she loved them so much she had never forgotten about them. And as it turns out they taste just as good when you make them ...


text:
Varsity Sleeve Stripe Raglan JumperProduct code: mzz76484
40% Acrylic, 40% Cotton, 20% Elastane
Varsity Sleeve Stripe Raglan Jumper
Model Is 6'1" And Wears UK Size M.
We hope you are satisfied with all of your purchases but if you ever need to return an item, you can do so within 28 days from the date your parcel was dispatched.
Please note, we cannot offer refunds on pierced jewellery or on swimwear if the hygiene seal is not in place or has been broken.
Click here to view our full Returns Policy.
We think you'll
Recently Viewed Items


text:
Britain's Bradley Wiggins safely overcame his first important climbing challenge in Paris-Nice's first hilly stage yesterday when he finished in the main pack and with his overall lead intact.
Spaniard Alejandro Valverde snatched the stage win with a late charge for the line, situated at the summit of a 5km climb near Lac de Vassivière.
"It was up and down all day, at a really tough tempo and it took its toll," Sky sports director Sean Yates said. "Defending the jersey and keeping Bradley out of trouble was our main objective, we did that and it was all good."
Yates is increasingly confident Wiggins can win the race outright.
"Looking at Bradley's form since the start of the race, you could almost say that if he stays upright and out of trouble, he should win."
An overall victory would be Britain's first in Paris-Nice since Tom Simpson in 1967, and only four GB riders have led it before.
- More about:
- Spain


text:
Order online Mental Disorders Piracetam Chlorpromazine 50/100mg low prices overnight delivery, Buy low price Piracetam without prescription online pharmacy
Active ingredient: Chlorpromazine
Category: Mental Disorders
Generic Thorazine is used for treating certain mental or mood disorders (eg, schizophrenia), the manic phase of manic-depressive disorder, anxiety and restlessness before surgery, porphyria, severe behavioral and conduct disorders in children, nausea and vomiting and severe hiccups. It is also used with other medicines to treat symptoms associated with tetanus.
Brand(s): Chlorpromazine Tablets
Manufacturer: Sun Pharma
Disease(s): Schizophrenia / Manic-depressive Disorder / Anxiety / Porphyria / Nausea / Vomiting / Hiccups / Tetanus
Dosage(s): 50/100mg
Order online Mental Disorders Piracetam Chlorpromazine 50/100mg low prices overnight delivery - Order cheap mental disorders online
Strattera Atomoxetine 10/18/25/40mg 30/60/90/120/180/360 pills
Buspar Buspirone 10mg 30/60/90/120/180/360 pills
Depakote Divalproex 125/250/500mg 30/60/90/120/180/360 pills
Paxil Paroxetine 10/20/30/40mg 30/60/90/120/180/240/360 pills
Effexor Venlafaxine 37.5/75mg 10/30/60/90/120/180/360 pills
Lamictal Lamotrigine 25/50/100mg 30/60/90/120/180/360 pills
Geodon Ziprasidone 20/40mg 30/60/90/120/180/360 pills
Lithobid Lithium 300mg 30/60/90/120/180/360 pills
Compazine Prochlorperazine 5mg 30/60/90/120/180/360 pills
Anafranil Clomipramine 10/25/50mg 30/60/90/120/180/360 pills
Risperdal Risperidone 1/2/3/4mg 30/60/90/120/180/360 pills
Nootropil Piracetam 400/800mg 30/60/90/120/180/270/360 pills
Seroquel Quetiapine 25/50/100/200/300mg 30/60/90/120/180/360 pills
Zyprexa Olanzapine 2.5/5/7.5/10/15/20mg 30/60/90/120/180/360 pills
Clozaril Clozapine 25/100mg 10/20/30/60/90/120 pills
Thorazine Chlorpromazine 50/100mg 30/60/90/120/180/360 pills
Feelings Of Guilt During Childhood Linked To Mental Illness. Jan 7 2015 Excessive guilt is a known symptom of adult depression but a new study finds that such feelings in childhood can predict future mental illness . Guilt Definition & Patient Education - Healthline. Many diseases and mental disorders have symptoms that include feelings of guilt especially those related to mental health
Embryo-Fetal Toxicity: Methotrexate has been reported to cause fetal death and/or congenital anomalies. In men, the number of hypomanic episodes usually equals or exceeds the number of depressive episodes. Renal excretion is the primary route of elimination and is dependent upon dosage and route of administration, and of course Buy online Mental Disorders Thorazine Chlorpromazine 50/100mg cheapest fast Delivery with VISA in USA. Biol Psychiatry 2007 Feb 15 [published online ahead of print], or Buy online Mental Disorders Neurocetam Chlorpromazine 50/100mg low prices in USA. McGreevy is not suggesting that all small dogs are psychological basket cases, and of course Order online generic Piracetam Chlorpromazine 50/100mg online pharmacy overnight delivery with VISA in USA. In order to avoid alienating any particular constituency of mental health professionals, Buy online generic Piracetam Chlorpromazine 50/100mg price overnight shipping with VISA in USA, the DSM has strategically adopted an atheoretical stance on the etiology (causes) of mental disorders. Examples include lying, Order online generic Piracetam Chlorpromazine 50/100mg without prescription overnight delivery with VISA, theft, aggression, truancy, fire setting, and vandalism. Yet it only begins to assess how an overwhelmed criminal justice system has become the de facto caretaker of Americans who are mentally ill and emotionally disturbed. These reactions are most likely related to marijuana interactions with certain chemicals in the brain, including the neurotransmitter dopamine. That what happened to me, Buy online Mental Disorders Thorazine Chlorpromazine 50/100mg cheap fast Delivery with VISA in USA, anyway. Most mental illnesses don't improve on their own, and if untreated, a mental illness may get worse over time and cause serious problems. Some medications need to be gradually stopped to give the body time to adjust.
Diagnostic and Statistical Manual of Mental Disorders Fifth Edition. Buy Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) by American Psychiatric Association (ISBN: 9780890425558) from Amazon's
Related articles: Order online generic Orlistat Orlistat 60/120mg price overnight delivery with Mastercard
Lexapro zoloft anxiety - Buy low cost Lexapro no prescription online pharmacy
Flexeril 15/30mg pills without prescription low cost overnight shipping Mississippi with Mastercard - Buy low cost Flexeril no prescription online
Prednisolone 40mg capsule no prescription purchase with Mastercard - Order Prednisolone without prescription online pharmacy
Zithromax 500 beipackzettel - Order low price Zithromax without prescription


text:
Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats
- Guo-Xin Ni1Email author,
- Li-Qiong Zhan2,
- Mei-Qin Gao3,
- Lei Lei2,
- Yue-Zhu Zhou2 and
- Yan-Xia Pan2Email author
DOI: 10.1186/ar3521
© Ni et al.; licensee BioMed Central Ltd. 2011
Received: 14 July 2011
Accepted: 24 November 2011
Published: 24 November 2011
The effect of intra-articular injection of matrix metalloproteinase (MMP)-3 inhibitor was investigated in a rat model to understand the role of MMP-3 in cartilage degradation induced by excessive loading from running.
A total of 24 male Wistar rats were randomly assigned into groups of sedentary control (SED), high-intensity running (HIR), HIR + low dosage of MMP-3 Inhibitor I (HIRI1), and HIR + high dosage of MMP-3 Inhibitor I (HIRI2). Rats in the HIR, HIRI1 and HIRI2 groups were intensively trained for six weeks on the treadmill. Those in HIRI1 and HIRI2 groups were provided bilateral intra-articular injections of 80 μL of 0.2 mM and 2 mM MMP-3 Inhibitor I in knee joints once a week, respectively. Blood samples were collected to measure serum MMP-3 level using ELISA. Femoral condyles were collected to observe cartilage characteristics by histochemistry, and MMP-3 as well as collagen II was measured by immunohistochemistry. In addition, cartilage samples were obtained to assess MMP-3 mRNA expression by RT-PCR.
Histological examination showed osteoarthritic changes in rats after six weeks of high intensity running. In comparison to the SED group, significant decreases in glycosaminoglycans (GAG) and collagen content were found in the HIR group, which corresponded to significant increase in serum MMP-3 level, cartilage MMP-3 activity and gene expression. However, such a degradative process was considerably retarded by intra-articular injection of MMP-3 inhibitor at higher dosage. Statistical differences were found between the HIR and HIRI2 groups with regard to GAG and collagen II content, serum MMP-3 level, cartilage MMP-3 activity and gene expression.
High-intensity running for six weeks may lead to cartilage degradation in a rat model. It was shown that the chrondroprotective effect was offered by the use of intra-articular injection of MMP-3 inhibitor. MMP-3 acts as the key mediator of this catabolic change under such mechanical condition. The results also showed that MMP-3 selective inhibitor may be an effective option for retarding such osteoarthritic changes.
Keywordsrunning exercise MMP-3 cartilage osteoarthritis inhibitor
While the homeostasis of joints was stabilized in a physiological range of mechanical loading, non-physiological mechanical loading and both overloading and reduced loading, may have deleterious effects, particularly on their cartilaginous components [1–3]. Running is one of the most common weight-bearing activities, and moderate running exercise was found to protect against cartilage degradation in hamsters that could spontaneously develop osteoarthritis (OA) [4]. Nevertheless, excessive running loading was correlated with deleterious effects on cartilage [5–8], hence, an excessive running-induced animal model can serve as a reliable OA model [8].
Excessive mechanical stress can directly damage the cartilage extracellular matrix (ECM) and shift the balance in chondrocytes to favor catabolic activity over anabolism [9]. Catabolism of the cartilage ECM was defined by the occurrence of degradation of both collagen fibrils and proteoglycans [10]. This involves a variety of degradative enzymes, notably matrix metalloproteinases (MMPs), whose basic role is to cleave and initiate the degradation of cartilage components [11]. The MMP family mainly consists of the collagenases (MMPs 1, 8, and 13), which degrade collagen; the gelatinases (MMPs 2 and 9), which target denatured collagen; and the stromelysins (MMPs 3, 7, 10, and 11), which degrade several ECM proteins and are involved in proenzyme posttranslational activation [12].
In vitro and in vivo studies indicated that a variety of MMPs may be responsive to diverse loading parameters, and may promote degradation of the cartilage collagens and proteoglycan under non-physiological loading conditions [2, 7, 13–16]. Among the MMPs family, MMP-3 appears to be one of the few genes that is up-regulated during the early stage of degeneration [17]. In addition, MMP-3-knockout mice showed a 67% reduction in cartilage damage occurring through spontaneous OA [18]. Furthermore, in a rat model, elevated MMP-3 activity was coincident with osteoarthritic changes in the knee which were induced by intensive running [7]. Although it is believed that MMP-3 may be a key mediator in pathological cartilage matrix degradation, it remains unclear as to its roles in the pathology of cartilage degradation, particularly in which was induced by excessive running loading. All in all, in this current study, a MMP-3 selective inhibitor was administrated to observe whether it offered a protective effect on cartilage degradation induced by excessive running loading and, subsequent to a further understanding of the roles, whether MMP-3 could have a part in the degradation of cartilage ECM under such mechanical conditions.
Materials and methods
Experimental animals and study protocol
A total of 24 male Wistar rats (12 to 13 weeks old, weighing 200 to 250 g) were randomly and evenly assigned to one of four groups as follows: 1) sedentary control (SED), 2) high intensity running (HIR), 3) high intensity running + low dosage of MMP-3 Inhibitor I (HIRI1), and 4) high intensity running + high dosage of MMP-3 Inhibitor I (HIRI2). Rats were housed in cages under controlled light/dark (12/12 h) and temperature (22 ± 1°C) conditions, and were provided with food and water ad libitum. They were adapted to laboratory conditions for one week before experiments began. The experiment was approved by the animal ethics committee of the institute.
Rats in the HIR, HIRI1 and HIRI2 groups were first accustomed to exercise for one week, by running on a treadmill at the speed of 10 m/minutes for 30 minutes/day. In the subsequent six weeks, they were regularly trained for 1 h/day at the frequency of five days/week, while the speed and inclination of the treadmill were adjusted to 25 m/minute and 12°, which were used to elicit high intensity (85% VO2max values) for Wistar rats [19]. Those rats in the HIRI1 and HIRI2 groups were provided intra-articular injections of 80 μL of 0.2 mM and 2 mM MMP-3 Inhibitor I (Chemical formula C27H46N10O9S, EMD Biosciences, Inc. San Diego, CA, USA) in knee joints bilaterally once a week, respectively.
Serum MMP-3concentration
After six weeks, the blood of all rats was collected prior to sacrifice and stored at -80°C until assayed. Serum levels of MMP-3 were measured using commercial enzyme-linked immunosorbent assay kits (ELISA, R & D Systems Inc., Minneapolis, MN, USA) according to the manufacturer 's protocol.
Tissue preparation
For histological morphology and immunohistochemistry examinations, femoral condyles on the right sides of rats in each group were dissected and fixed in 4% buffered formaldehyde pH 7.4 for 24 hours. Decalcification was completed in 10% EDTA solution, and then the samples were embedded in paraffin wax. Thereafter, they were cut into 5-mm sagittal sections in the medial region.
For the real-time PCR analysis, articular cartilage samples from femoral condyles on the left sides were obtained with a scalpel or rongeur, and flash-frozen in liquid nitrogen at -80°C.
Histomorphological evaluation
The samples were stained with Safranin-O and histomorphologically evaluated with Mankin grading system, which was previously applied to many experimental OA models [4–8], and proven to be sensitive to early OA changes induced by treadmill exercise [8]. The histological evaluation system for OA was classified into four categories: Mankin score of 0, no OA; Mankin scores of 1 to 5, mild OA; scores of 6 to 10, moderate OA, and scores 11 to 14, severe OA. All sections were graded by two independent observers that were kept unaware of the groups.
Digital densitometry was used for the evaluation of the glycosaminoglycans (GAG) content. For each section, six different areas were digitally captured with a color video camera attached to a light microscope. Illumination intensity and image magnification were kept constant for all images captured. The information was assessed with computer image analysis software (Nikon H600L Microscope and image analysis system, Tokyo, Japan). The values of optical density in six areas were averaged to be GAG content in each section.
Immunohistochemistry for MMP-3 and collagen type II
In addition to histomorphological evaluation, immunohistological analysis for MMP-3 and collagen type II was performed in all sections. After deparaffinization and rehydration of the tissue sections, MMP-3 and collagen type II were respectively immunostained with the two-step immunohistochemistry method instructed by the manufacturer (Zhongshan Goldenbridge Biotechnology Co., Ltd, Beijing, China).
The sections were incubated with rabbit polyclonal antibody against rat MMP-3 (1:50 dilution, Santa Cruz Biotechnology, Santa Cruz, CA, USA) for 3.5 h at 29°C. The slides were washed in PBS three times, and followed by a 20-minute incubation at 37°C with goat anti-rabbit anti-MMP-3 immunoglobulin G (IgG) (Santa Cruz Biotechnology) and visualized with DAB chromagen. The slides were stained for 40 s, and then we counterstained the nucleus with hematoxylin for 6 s. Negative control sections were prepared with the same protocol above, but primary antibody was replaced by PBS. Immunostaining for MMP-3 in the joint cartilage was evaluated by calculating the ratio of the number of MMP-3 immunoreactive chondrocytes to the total number of chondrocytes within each section.
The procedure of staining collagen type II was similar to the protocol mentioned above with the following changes: monoclonal mouse antirat collagen type II antibody (1:200 dilution, Fisher Scientific, Chicago, IL, USA) was applied as the primary antibody, and anti-mouse IgG/HRP (Fisher Scientific) as the secondary antibody. The collagen type II content was evaluated based on optical density measured using image analysis software (Nikon H600L Microscope and image analysis system).
Real-time PCR analysis
The samples were frozen in liquid nitrogen, and then were broken into pieces with a masher. The fragments were then mixed and placed in a vessel containing 1 ml Trizol, then centrifuged at 12,000 rpm for 15 minutes at 4°C. Afterwards, 0.2 mL chloroform was added prior to mixing, the supernatant was removed after centrifugation at 12,000 rpm for 15 minutes at 4°C. Then 500 mL isopropanol was added and the samples were once again centrifuged at 12,000 rpm for 15 minutes at 4°C. The supernatant was discarded; 75% ethanol and 500 mL DEPC-treated H2O were added. The samples were centrifuged at 7,000 rpm for five minutes at 4°C, the supernatant was discarded, and the pellet was air dried. Subsequently, 30 mL of DEPC-treated H2O was added. Reverse transcription of the mRNA to template cDNA was completed with the transcription RT Kit (TaKaRa Biotech Co., Ltd., Dalian, China). Two nanograms of total RNA were analyzed by real-time PCR with SYBR Green to assess MMP-3 expression, and β-actin as housekeeper. PCR primers pairs (Bio Teke Co., Ltd., Beijing, China) used were: MMP-3, forward 5'-GGGAAGCTGGACTCGAACACT-3', reverse 5'-TGAGCAGCAACCAGGAATAGG-3'; β-actin, forward 5'-CCCATCTATGAGGGTTACGC-3', reverse 5'-TTTAATGTCACGCACGATTTC-3'. Expression values of β-actin for each group were averaged and used as a denominator to determine the relative expression level of MMP-3.
Statistical analysis
Results are expressed as the mean ± standard deviation. Statistical analysis was carried out using a one-way ANOVA and Tukey's test for post hoc analysis with significance set at P < 0.05.
Histological evaluation
Serum MMP-3 level
mRNA gene expression of MMP-3
Mechanical loading of articular cartilage is essential to regulate the metabolic activity of chondrocytes, and is required for maintaining normal ECM properties. However, it is generally believed that excessive mechanical loading contributes to the degeneration of cartilage and the onset of OA [20]. Rats running 500 m/day in a running wheel for 12 weeks showed local softening of the articular cartilage and decreased GAG content [7]. Early degeneration of cartilage was observed in rats running 1,500 m/day for 10 weeks at a 5° incline on the treadmill [8]. In this current study, rats running 1,500 m/day for six weeks at a 12° incline on the treadmill also showed early degeneration of cartilage. This indicated that during high intensity running, excessive running load was applied on cartilage in the knee joint, which led to cartilage degradation.
Among the many cellular activities reported to be subject to mechanical regulation are the expression and activation of MMPs in vivo and in vitro [21]. It was reported that chondrocytes respond to a range of mechanical loading conditions through diverse metabolic responses, including MMPs synthesis [13–15, 22]. Various mechanical loading may encourage different MMPs expression in cartilage chondrocytes [17]. In particular, Pap et al. described that load-dependent running increased the immunoreactivity of MMP-3 in a rat model [7]. In this current study, mild cartilage degradation was found in rats with high-intensity running exercise for six weeks, which corresponded with a significant increase of MMP-3 activity and gene expression. To further confirm the important role of MMP-3 in cartilage degradation, intra-articular injection of MMP-3 inhibitor I was administered. Our findings suggested that the cartilage catabolic change could be retarded by the use of MMP-3 inhibitor I. The results also demonstrated that MMP-3 may act as the key mediator of cartilage degradation, particularly as the result of excessive running.
Along with MMP-3 activity and gene expression in cartilage, the serum MMP-3 level was found to be significantly higher in this study following excessive running for six weeks. In human studies, an elevated serum MMP-3 level has been observed in subjects with joint injury [23] and OA [24–26]; serum MMP-3 level may predict the rate of cartilage loss in an OA joint [27]. Interestingly, our results indicated that serum MMP-3 level decreased after intra-articular MMP-3 inhibitor treatment. The findings of the reduction in MMP-3 gene expression in the current study demonstrated that intra-articular MMP-3 inhibitor treatment could prevent the continuous synthesis of MMP-3. Therefore, the decrease of serum MMP-3 level after treatment could be the results of the reduction of MMP-3 molecules synthesized and/or released from the joint after the treatment. However, as a systemic OA biomarker, the serum level of MMP-3 reflected that the changes not only occur in the signal joint, but also in other joints. This may partially explain the finding in our study that the serum MMP-3 level in the HIRI2 group was still approximately two-fold higher than that in the control group.
In this current study, MMP-3 levels, both in serum and cartilage, increased significantly in rats with high-intensity running for six weeks, which was mirrored with the loss of proteoglycan and collagen II. More importantly, such changes in GAG and collagen II induced by high intensity running was reversed by MMP-3 inhibitor treatment, which also implied the requirement of MMP-3 in regulating proteoglycan and collagen II homeostasis. It was, therefore, not surprising that MMP-3 expression corresponded to the appearance of GAG loss in cartilage following high-intensity running, and could be suppressed by the MMP-3 inhibitor. Proteoglycans provide elasticity and lubricity to the joint surface. Aggrecan degradation is an early sign of ECM destruction in osteoarthritic cartilage. On the other hand, type II collagen content was found reduced significantly followed by high-intensity running, which may be explained by the fact that MMP-3 contributed indirectly to the breakdown of type II collagen by activating other MMPs [28]. Collagen fibrils form a meshwork that provides tensile resistance of the cartilage. Tensile failure of the collagen meshwork has been proposed as an important mechanism of failure of articular cartilage [29].
Our results showed that the degradation of cartilage ECM was induced by excessive loading from running in a rat model. In vitro evidence suggested that overloading may also lead to chondrocyte death [30, 31]. In human OA cartilage, higher numbers of apoptotic chondrocytes were found than those in normal cartilage, suggesting that apoptosis plays an important role in the development of OA [32, 33]. In a literature review, Kuht et al. indicated that cell death and extracellular matrix degradation are linked and contribute to the chronic matrix remodeling process that characterizes OA [34]. As such, it is assumed that the number of apoptotic chondrocytes may increase following excessive running loading, which contributes to the matrix degradation demonstrated in our study. However, to understand the extent of cell death in this model, as well as whether the MMP-3 inhibitor protects against cell death, further investigations using the TUNEL technique are required.
Due to the important roles in the pathology of cartilage matrix degradation, MMPs have long been considered excellent potential treatment for OA, and inhibition of their activities has proven to be efficacious in a variety of models of experimentally induced as well as spontaneously occurring OA [35–38]. Mainly because of the musculoskeletal side effects caused by the use of broad-spectrum MMP inhibitors, current drug development strategies for treatment of OA are focused on inhibition of specific MMPs implicated in the disease process [39–41]. In this current study, intensity running would initiate the expression and activation of MMP-3, leading to catabolism of ECM in cartilage; such degradation could be retarded by the use of MMP-3 selective inhibitor at appropriate dosages. As such, intra-articular injection of MMP-3 inhibitor appears to be an effective treatment for retarding the cartilage degradative changes particularly induced by excessive running. However, as such inhibitive effects were found to be dosage-dependent in this current study, further investigations are required for the optimal dosage of MMP-3 inhibitor.
Mild cartilage degradation was observed in rats after high-intensity running for six weeks, and MMP-3 clearly acted as the key mediator of this catabolic change under such mechanical conditions. A chrondroprotective effect was provided by intra-articular injection of MMP-3 inhibitor, which not only confirmed the important role of MMP-3 in the changes of articular cartilage induced by excessive running load, but also suggested a possible effective treatment for retarding such osteoarthritic changes.
extracellular matrix
enzyme-linked immunosorbent assay
high-intensity running
- MMPs:
matrix metalloproteinases
polymerase chain reaction
sedentary control.
We gratefully acknowledge Ms. N. Dang for technical assistance. This work was supported by special funding for university talent introduction of Guangdong Province (G-XN) and Doctoral seeding fund of Fujian Medical University 2007BS004 (G-XN).
Authors' Affiliations
- Saxon L, Finch C, Bass S: Sports participation, sports injuries and osteoarthritis: implications for prevention. Sports Med. 1999, 28: 123-135. 10.2165/00007256-199928020-00005.View ArticlePubMedGoogle Scholar
- Chang Q, Huang C, Huang Z: Matrix metalloproteinases and inhibitor in knee synovial fluid as cartilage biomarkers in rabbits: the effect of high-intensity jumping exercise. J Surg Res. 2007, 140: 149-157. 10.1016/j.jss.2006.12.556.View ArticleGoogle Scholar
- Vanwanseele B, Lucchinetti E, Stussi E: The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions. Osteoarthritis Cartilage. 2002, 10: 408-419. 10.1053/joca.2002.0529.View ArticlePubMedGoogle Scholar
- Otterness IG, Eskra JD, Bliven ML: Exercise protects against articular cartilage degeneration in the hamster. Arthritis Rheum. 1998, 41: 2068-2076. 10.1002/1529-0131(199811)41:11<2068::AID-ART23>3.0.CO;2-L.View ArticlePubMedGoogle Scholar
- Kaiki G, Tsuji H, Yonezawa T, Sekido H, Takano T, Yamashita S, Hirano N, Sano A: Osteoarthrosis induced by intra-articular hydrogen peroxide injection and running load. J Orthop Res. 1990, 8: 731-740. 10.1002/jor.1100080515.View ArticlePubMedGoogle Scholar
- Galois L, Etienne S, Grossin L, Watrin-Pinzano A, Cournil-Henrionnet C, Loeuille D, Netter P, Mainard D, Gillet P: Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study. Osteoarthritis Cartilage. 2004, 12: 779-786. 10.1016/j.joca.2004.06.008.View ArticlePubMedGoogle Scholar
- Pap G, Eberhardt R, Sturmer I, Machner A, Schwarzberg H, Roessner A, Neumann W: Development of osteoarthritis in the knee joints of Wistar rats after strenuous running exercise in a running wheel by intracranial self-stimulation. Pathol Res Pract. 1998, 194: 41-47. 10.1016/S0344-0338(98)80010-1.View ArticlePubMedGoogle Scholar
- Lee YJ, Park JA, Yang SH, Kim KY, Kim BK, Lee EY, Lee EB, Seo JW, Echtermeyer F, Pap T, Song YW: Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system. Rheumatol Int. 2011, 31: 1571-1576. 10.1007/s00296-010-1520-4.View ArticlePubMedGoogle Scholar
- Sun HB: Mechanical loading, cartilage degradation, and arthritis. Ann N Y Acad Sci. 2010, 1211: 37-50. 10.1111/j.1749-6632.2010.05808.x.View ArticlePubMedGoogle Scholar
- Aigner T, McKenna L: Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci. 2002, 59: 5-18. 10.1007/s00018-002-8400-3.View ArticlePubMedGoogle Scholar
- Cawston TE, Wilson AJ: Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. Best Pract Res Clin Rheumatol. 2006, 20: 983-1002. 10.1016/j.berh.2006.06.007.View ArticlePubMedGoogle Scholar
- Burrage PS, Mix KS, Brinckerhoff CE: Matrix metalloproteinases: role in arthritis. Front Biosci. 2006, 11: 529-543. 10.2741/1817.View ArticlePubMedGoogle Scholar
- Blain EJ, Mason DJ, Duance VC: Effect of mechanical stimulation on MMP expression in chondrocytes. Biorheology. 2003, 40: 111-117.PubMedGoogle Scholar
- Jin G, Sah RL, Li YS, Lotz MJ, Shyy YJ, Chien S: Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res. 2000, 18: 899-908. 10.1002/jor.1100180608.View ArticlePubMedGoogle Scholar
- Trindade MC, Shida DJ, Ikenoue T, Lee MS, Lin EY, Yaszay B, Yerby S, Goodman SB, Schurman DJ, Smith RL: Intermittent hydrostatic pressure inhibits matrix metalloproteinase and proinflammatory mediator release from human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage. 2004, 12: 729-735. 10.1016/j.joca.2004.05.008.View ArticlePubMedGoogle Scholar
- Leong DJ, Gu X, Lee JY, Li Y, Mahammud R, Majeska RJ, Cardoso L, Sun HB: Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Matrix Biol. 2010, 29: 420-426. 10.1016/j.matbio.2010.02.004.PubMed CentralView ArticlePubMedGoogle Scholar
- Aigner T, Zien A, Gehrsitz A, Gebhard PM, McKenna L: Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum. 2001, 44: 2777-2789. 10.1002/1529-0131(200112)44:12<2777::AID-ART465>3.0.CO;2-H.View ArticlePubMedGoogle Scholar
- Blom AB, van Lent PL, Libregts S, Holthuysen AE, van der Kraan PM, van Rooijen N, van den Berg WB: Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. Arthritis Rheum. 2007, 56: 147-157. 10.1002/art.22337.View ArticlePubMedGoogle Scholar
- Bedford TG, Tipton CM, Wilson NC, Oppliger RA, Gisolfi CV: Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol. 1979, 47: 1278-1283.PubMedGoogle Scholar
- Buckwalter JA, Martin JA: Osteoarthritis. Adv Drug Deliv Rev. 2006, 58: 150-167. 10.1016/j.addr.2006.01.006.View ArticlePubMedGoogle Scholar
- Blain EJ: Mechanical regulation of matrix metalloproteinases. Front Biosci. 2007, 12: 507-527. 10.2741/2078.View ArticlePubMedGoogle Scholar
- Lin PM, Chen CTC, Torzilli PA: Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3-and 7D4) and collagen damage in cyclically load-injured articular cartilage. Osteoarthritis Cartilage. 2004, 12: 485-496. 10.1016/j.joca.2004.02.012.View ArticlePubMedGoogle Scholar
- Catterall JB, Stabler TV, Flannery CR, Kraus VB: Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). Arthritis Res Ther. 2010, 12: R229-10.1186/ar3216.PubMed CentralView ArticlePubMedGoogle Scholar
- Manicourt DH, Fujimoto N, Obata K, Thonar EJ: Serum levels of collagenase, stromelysin-1, and TIMP-1: age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratin sulfate in patients with osteoarthritis. Arthritis Rheum. 1994, 37: 1774-1783. 10.1002/art.1780371211.View ArticlePubMedGoogle Scholar
- Sasaki S, Iwata H, Ishiguro N, Obata K, Miura T: Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis. Clin Rheumatol. 1994, 13: 228-233.PubMedGoogle Scholar
- Yoshihara Y, Obata K, Fujimoto N, Yamashita K, Hayakawa T, Shinmei M: Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis. Arthritis Rheum. 1995, 38: 969-975. 10.1002/art.1780380713.View ArticlePubMedGoogle Scholar
- Lohmander LS, Brandt KD, Mazzuca SA, Katz BP, Larsson S, Struglics A, Lane KA: Use of the plasma stromelysin (Matrix Metalloproteinase-3) concentration to predict joint space narrowing in knee osteoarthritis. Arthritis Rheum. 2005, 52: 3160-3167. 10.1002/art.21345.View ArticlePubMedGoogle Scholar
- Poole AR: Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis. Rheum Dis Clin North Am. 2003, 29: 803-818. 10.1016/S0889-857X(03)00056-5.View ArticlePubMedGoogle Scholar
- Weightman B, Freeman MAR, Swann AC: Fatigue of articular cartilage. Nature. 1973, 244: 303-304. 10.1038/244303a0.View ArticlePubMedGoogle Scholar
- Quinn TM, Allen RG, Schalet BJ, Perumbuli P, Hunziker EB: Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stress. J Orthop Res. 2001, 19: 242-249. 10.1016/S0736-0266(00)00025-5.View ArticlePubMedGoogle Scholar
- Torzilli PA, Grigiene R, Borrelli J, Helfet D: Effect of impact load on articular cartilage: cell metabolism and viability, and matrix water content. J Biomech Eng. 1999, 121: 433-441. 10.1115/1.2835070.View ArticlePubMedGoogle Scholar
- Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ, Galdo F: Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum. 1998, 41: 284-289. 10.1002/1529-0131(199802)41:2<284::AID-ART12>3.0.CO;2-T.View ArticlePubMedGoogle Scholar
- Bobacz K, Erlacher L, Smolen J, Soleiman A, Graninger WB: Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage. Ann Rheum Dis. 2004, 63: 1618-1622. 10.1136/ard.2002.002162.PubMed CentralView ArticlePubMedGoogle Scholar
- Kuhn K, D'Lima DD, Hashimoto S, Lotz M: Cell death in osteoarthritis. Osteoarthritis Cartilage. 2004, 12: 1-16.View ArticlePubMedGoogle Scholar
- Aranapakam V, Davis JM, Grosu GT, Baker J, Ellingboe J, Zask A: Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. J Med Chem. 2003, 46: 2376-2396. 10.1021/jm0205550.View ArticlePubMedGoogle Scholar
- Sabatini M, Lesur C, Thomas M, Chomel A, Anract P, de Nanteuil G, Pastoureau P: Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis. Arthritis Rheum. 2005, 52: 171-180. 10.1002/art.20900.View ArticlePubMedGoogle Scholar
- Brewster M, Lewis EJ, Wilson KL, Greenham AK, Bottomley MK: Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis. Arthritis Rheum. 1998, 41: 1639-1644. 10.1002/1529-0131(199809)41:9<1639::AID-ART15>3.0.CO;2-0.View ArticlePubMedGoogle Scholar
- Natchus MG, Bookland RG, De B, Almstead NG, Pikul S, Janusz MJ, Heitmeyer SA, Hookfin EB, Hsieh LC, Dowty ME, Dietsch CR, Patel VS, Garver SM, Gu F, Pokross ME, Mieling GE, Baker TR, Foltz DJ, Peng SX, Bornes DM, Strojnowski MJ, Taiwo YO: Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines. J Med Chem. 2000, 43: 4948-4963. 10.1021/jm000246e.View ArticlePubMedGoogle Scholar
- Clark IM, Parker AE: Metalloproteinases: their role in arthritis and potential as therapeutic targets. Expert Opin Ther Targets. 2003, 7: 19-34. 10.1517/1472818.104.22.168.View ArticlePubMedGoogle Scholar
- Renkiewicz R, Qiu L, Lesch C, Sun X, Devalaraja R, Cody T: Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats. Arthritis Rheum. 2003, 48: 1742-1749. 10.1002/art.11030.View ArticlePubMedGoogle Scholar
- Li NG, Shi ZH, Tang YP, Wang ZJ, Song SL, Qian LH, Qian DW, Duan JA: New hope for the treatment of osteoarthritis through selective inhibition of MMP-13. Curr Med Chem. 2011, 18: 977-1001. 10.2174/092986711794940905.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited


text:
Invaluable cannot guarantee the accuracy of translations through Google Translate and disclaims any responsibility for inaccurate translations.
Show translation options
Lot 446: Women at a watermelon party.
Photographs: Cabinet Cards & some Civil War
by Be-Hold
October 29, 2016
Yonkers, NY, USALive Auction
Looking for the realized and estimated price?
Description: Women at a watermelon party. It's interesting to compare the way they are grouped with adventurous daguerreian groupings from 40 years before. They are identified in the verso, with an 1893 date. See Lot 211 for other outstanding groupings. By O. F. Waegan, Burlington, Kansas. )
Condition Report: [4]
Browse more items


text:
I'm a 3D artist from Barcelona. I'm mostly a character artist and i don't have much experience in this field. But i wanted to try and do my best, and sure i had a great time doing this!
notify me when new comments are added
Get to know us
3D models
3D services
© 2005 - 2017, All Rights Reserved - Hum3D.com, a ParaART, LLC company
choice of professionals


text:
Numark Virtual Vinyl 5 DJ System with Audio Interface is Numark's premier DJ system that lets you scratch, mix and sample digital audio and video with your computer and a turntable or CD player.
A very reliable DJ hardware and software solution that lets you scratch, mix and sample digital audio and video files using any analog turntable, CD player or HD player. Virtual Vinyl 5 comes complete with Numark's world-class CUE 5 DJ software, a Numark USB audio interface, time code CDs and records, and more.
Using a traditional turntable or CD player (sold separately) with the included control vinyl or CDs, Virtual Vinyl 5 DJ system provides in-depth features including: master tempo, seamless looping, instant pitch-matching, automatic beat-matching, BPM-aware effects, hot-cues, sampling, and more.
What started as a simple string and pedal sales catalog has grown exponentially over the past thirty years. The early days were a time where catalogs didn't have much of a presence in the industry, but what began as a college dorm room operation grew rapidly. In 1986 we moved to a full product offering and 64-page catalog, which over the years has grown to 162 pages. Join the AMS family and get your free catalog now!
Copyright © 1996-2017 American Musical Supply, Inc. All rights reserved. American Musical Supply reserves the right to correct pricing and/or product specifications in the event of typographical errors found in our print catalog or on our website. If a product is listed at an incorrect price due to such errors or because of inaccurate information received from a supplier, American Musical Supply shall have the right to refuse or cancel any orders placed, whether or not the order has been confirmed and your credit card charged. If your credit card has already been charged for the purchase and your order is canceled, American Musical Supply will issue a credit to your credit card account in the amount of the charge.


text:
CORPORATE FINANCE - Something in the water - RWE was a far and happy German utility until deregulation forced it to compete at home and expand abroad. Now it's a global player -- A sprawling multiutility with billions of debt and potential deal indigestion.
|Year of Publication:
|Filman, Hugh
|Published in:
|Type of Publication:
|Title record from database:
| OLC-SSG Economic Sciences
|Check Google Scholar More access options
|More options (other):
|Description not available.
Saved in bookmark lists
Similar items by author
FEATURES - Easy does it - Investors love EasyJet's low-cost strategy. But is the British upstart flying too close to the sun?
By: Filman, Hugh Published: (2002)
FIXED INCOME - All together now - Bond buyers have cashed in big-time on European unification plays. Right now, Eastern Europe is hot.
By: Filman, Hugh Published: (2003)
INSURANCE - Recover-Re - Europe's reinsurance giants have survived epic disasters, corporate liabilities and even September 11. It was the equity markets that almost did them in.
By: Filman, Hugh Published: (2003)
- More


text:
Sign up for our newsletters
Receive the latest in Footwear, Fashion, Music and Creativity in our newsletters.
In collaboration with Heritage Research, wings + horns have produced a limited Fishtail jacket, specially designed for this fall/winter season. The piece comes constructed with a water-resistant British waxed cotton for all-weather versatility as well as hidden snaps, Swiss Riri zippers and a quilted liner made of a warm, natural cambric cotton. This release also includes a storm collar with zip out hood for extra protection. Look for it now through HAVEN, in-store and online.


text:
More Videos...
Lamborghini Replicas & Kit Cars
Compilation of Lamborghini Murcielago LP640 Replicas & Kitcars
Replica Veyron Fools Me
OK FINE maybe its fake. I get it, YouTube commenters are experts apparently. Who cares. I would drive that thing everyday. I saw this Veyron driving on I-285 today. I could hear the scraping as the car drove over the bumps in the road. Apologies for the shaking. It is hard to keep still in sight of such a beautiful car.
Lamborghini Aventador replica US$20,000
Lamborghini Aventador replica US$20,000
Lamborghini Murcielago LP640 Replica DONE RIGHT!!!
This is a full tour of Murcie-Me's Murcielago LP640 Replica based on a Fiero chassis. It uses the standard 2.8 V6 with a 3 speed Automatic trans like mine except he set it up with paddle shifters just like an original. The car has widetrack NAREC Suspension modeled after real lamborghini suspension so the car handles like its on rails. Probably as good if not better than the Corvette ZR1 I drove! It felt lighter than the standard Fiero however it probably is not. Overall I thought the car was pretty cool. I wouldn't mind building one myself. What do you guys think? I wanna see some video responses from guys who own real lamborghini's. Can you build one to match the original? or is it impossible? Side Notes I DO NOT SELL BODY KITS, if you ask, I will delete your comment, block you and flame you so don't bother. if you want this body kit. Go through Carkitinc and get the Mercy 2. Thats what this originally was a G28 through Triangle G then Inland exotics, now the Mercy 2/RobsLP640. Lots of people have been bitching about the quality. It's the video editing software upload that ruined the video! So don't bitch about the Sony Handicam sucking ass! Warning to anyone who dare downloads this video without my permission and reposts it along with my photos will be sued by me personally. Don't fuck with me! enjoy the video but don't abuse my content to scam people out of money otherwise you'll be in court with me. -VF1Skullangel


text:
In 2013, we spoke to well over 300 different companies offering products or services in either the virtualization market, the cloud computing market or both. What can we expect to see in the coming year.
One solution to China's massive smog problem? Lots of EV vending machines.
The latest exec to sit at the top of BlackBerry goes back the drawing board for what could be the beleaguered phone maker's last grasp at survival.
US demands in Trans-Pacific Partnership negotiations include patent protection for software and even of "mathematical methods".
Either Kevin and I are getting old and cranky or we are just tired of too much going on. We are both using the same smartphones now in an attempt to simplify our lives.
Predictably, stories about Microsoft's 'Blue' wave were the most popular on my blog in 2013. But the No. 1 trafficked story might surprise some.
CIOs and CEOs who are developing IoT strategies will function best in an innovative environment that accommodates failed projects in the pursuit of solid initiatives that return value to the business.
Amazon's preliminary Christmas sales information is in and Linux-powered gear was a holiday-season winner.
The most important stories aren't always those that win the most attention at the time. These are my picks for the important, but not always famous, 2013 stories.
The reduced pricing for the Surface RT made it a reasonable gift for the holidays. That may not be a good thing.
Some gadgets you can use as though they were your own, like tablets and televisions. But Google Glass, the new kid on the wearable technology block, extends the nature of "personal tech" to a whole new level — even more so than your trusty smartphone sidekick.
Beidou navigation system will comprise 30 satellites by 2020, as China looks to improve its accuracy to within centimeters to better compete with the U.S. system, currently used by the world's majority.
Rather than end the year with a 'best of' list or predictions for 2014, I'll be delivering 12 days of holiday gifts to you in the form of treppenwitz: all the afterthoughts I had all year.
Region's increasing demand for outsourcing services will boost the Indian ICT sector next year, with new projects expected from the region, predicts industry group Nasscom.
There've been a couple of recent developments of note regarding Microsoft's 'Midori' skunkworks operating system project.
With executive experience at Warner, Universal and Sony, Morris' knowledge of the music industry has few rivals.
APIs have characteristics and purposes outside the scope of service oriented architecture, one industry leader argues.
Rather than end the year with a 'best of' list or predictions for 2014, I'll be delivering 12 days of holiday gifts to you in the form of treppenwitz: all the afterthoughts I had all year.
Whither the world of energy prices during the next 12 months? Energy analyst Chris Nelder grades his 2013 oil and gas price forecast, and gazes into the crystal ball for his 2014 predictions.


text:
Enjoy free weekends with your wingman.
Get over 100 days of free electricity with the Reliant Truly Free Weekends plan.
I need an electricity plan
We have the perfect plan for you. Discover all Reliant has to offer.
I have an apartment
Get a low rate on electricity for your space. We have plans for you.
I'm already a customer
Reliant Rodeo plan
Lasso a low electricity price and a free pair of Justin Boots when you sign up for the Reliant Rodeo plan.
100% Solar
With the Reliant 100% Solar 12 plan, you don't need solar panels to support solar energy.
Plans that reward
Whether you're a sports fan or a frequent flier, we have options to fit your specific needs and lifestyle.
"Getting real excited when I log onto our @reliantenergy app to see our prospective bill get lower and lower."
-Rueben Pena


text:
DETROIT – There's nothing inherently funny about converting scrap Chevrolet Volt battery covers into wildlife habitats such as wood duck nesting boxes to bat houses, but it makes pretty good cartoon fare just the same.
Instead of sending that material to a landfill, GM reuses it to benefit wildlife, creating more than 150 of them so far at designated wildlife habitat areas surrounding its facilities, as well as other U.S. locations where GM environmental engineers work alongside students and community groups to convert them.
That prompted Birgit Keil, a green and cause-minded cartoonist and blogger, to draw her impressions of the project. Her blog contains more information about GM's effort and why swapping out insect killer for a bat house might be a smart, nature-friendly choice.
General Motors Co. (NYSE:GM, TSX: GMM) and its partners produce vehicles in 30 countries, and the company has leadership positions in the world's largest and fastest-growing automotive markets. GM's brands include Chevrolet and Cadillac, as well as Baojun, Buick, GMC, Holden, Isuzu, Jiefang, Opel, Vauxhall and Wuling. More information on the company and its subsidiaries, including OnStar, a global leader in vehicle safety, security and information services, can be found at http://www.gm.com.


text:
Showing results for "Drum Wheat Powder". Did you mean Drum Wheel Power
2 matching items were found.
Sort By
✔ Free Delivery ✔ 30-Day Replacement Guarantee ✔ Cash on Delivery ✔ Combo Deals.
2 offers for Drum Wheat Powder across various categories like Furniture, Sofas, SOFA SETS, THREE SEATER SOFAS, NA and brands like Comfort Couch are available.


text:
DEFENSIVE STOCKS are showing signs of life after underperforming for the past six months, notes Salomon Smith Barney, which thinks that the water, electricity and tobacco sectors might well have been oversold as investors made a dash for cyclical stocks.
Salomon names Scottish Power, Scottish & Southern, BG and National Power as preferred utility stocks while BATs and Imperial Tobacco are its preferred tobacco stocks, despite caution over US litigation and bootlegging in the UK.
BSkyB's DECLARATION of war in the pay-TV market, with its initiative to provide customers with free set-top boxes, does not provide enough upside potential with acceptable levels of risks for Lehman Brothers, which predicts underperform (607p) on the shares. It questions why BSkyB is being so aggressive if its digital launch was so successful, worrying that it might not hit its target of six million subscribers by 2003. It predicts the shares will trail by 10 per cent this month and by 5 per cent over the next three.Reuse content


text:
Madonna has proved she really is a material girl after being banned from a chain of cinemas for texting on her phone during a film.
The queen of pop flouted the universal code of cinema etiquette during the New York premiere of Steve McQueen's new film 12 Years a Slave.
Madonna's constant tapping is said to have annoyed the audience at the Walter Reade Theatre in New York's Lincoln Centre.
According to the New York Post, an audience member told Madonna to stop texting, to which she reportedly replied: "It's for business…enslaver!"
The news sparked Tim League, CEO of the Alamo Drafthouse Cinema in Austin, Texas, to ban the star from his chain of picture houses.
He tweeted: "Until she apologized to movie fans, Madonna is banned from watching movies @drafthouse."
After someone accused him of capitalising on the incident to make headlines, he said: "Madonna, however entitled she feels she is, is unbearably rude to others around her by texting in a theater."
He later told Entertainment Weekly that although his comment was initially meant as an "offhand joke, a spur of the moment 140 characters" and was "more of a means to get the issue out there, that it is rude to text during movies" he would stick to his guns.
"Now that it seems to have taken hold, sure, I'm going to enforce it. I'm serious, but I don't think it really affects her life that much," he said.
Alamo is well-known for enforcing strict cinema-going rules. Talking and texting is prohibited and can result in patrons being thrown out of the cinema.
12 Year's a Slave, starring Chiwetel Ejiofor, Michael Fassbender and Benedict Cumberbatch, tells the story of Solomon Northup, a free black man who was kidnapped in Washington DC and sold into slavery in 1841.
The film is a British-American venture, directed by Steve McQueen, whose previous credits include Shame and Hunger.Reuse content


text:
Mashing it up again inna Echo Chamber. Tonight featured the excellent new Dubmatix "Clash Of The Titans – The System Shakedown Remixes". Also finally getting to Cherine's free "mixtape" release JA9.25. And an interesting new release Fully Bearded – 15 Years of Tummy Touch Records in Dub in the mix tonight. Finally, woven throughout tonight's program was Kevin Purdy's cool new ambient soundscape album "Illumination" (on Soft Records).
Poet Gerry LaFemina talks about his newest book of poetry, Vanishing Horizon. He is currently the Director of the Frostburg Center for Creative Writing in Frostburg, Maryland. Before his career as a poet and professor, he was the lead singer of the hardcore punk band Expletive Deleted and the ska band Tom Collins and the Cocktail Shakers.
Also, we chat with Jason Skipper about his debut novel Hustle, featuring an alcoholic ex-con man grandfather who has has hustled for money and now redemption, his restless, philandering seafood salesman son who has has hustled for women and now hustles for love of a different sort, and his hopeful musician grandson struggling to make up for their past and somehow set course for the future.
Two interviews today,#1) Kelley Hunt who is playing at the Dakota in Mpls on December 2nd and 3rd, and #2) over in St. Paul at Wilebski's Blues Saloon, Mississippi Heat on December 2nd. We talked with harmonica man, Pierre LaCocoque from that band. Two great interviews but only had time for 16 songs. See play list below:
Living Esctacy Satyen Raja
Living Ecstasy is about Waking Up with humor and with Love. Living Ecstasy is not a "get-happy-in-10-easy-steps" type of book. Living Ecstasy assumes that you are not broken or needy. You do not lack anything.
Kinshasha's conversation with Satyen Raja is a beautiful conversation about living our lives in joy.
Living Ecstasy is designed to be an invitation and a challenge. Ignite your deepest passion and claim your birthright! Do not wait another moment to give your Love and Freedom, and to feel the full expression of Life.
Satyen's deepest purpose for living is to make it possible for others to Awaken in a way that is real, practical and sustainable. He is the President and founder of WarriorSage, one of the leading spiritual growth organizations in the world.
Steam Dreamers of Inverness, Part 2 – From ZBS. We continue the story with Chapters 3 & 4.
Is your first or third skin a hot spot? First skin is the thing that bounds our physical being; second skin is our clothes; third skin is the built environment we live and work in.
Hosted by Paula Quinlan and Midwest Building Ecology Coalition.
Kohl Miner, Indigenous storyteller and Allison Heimstead, director of WINTER DREAMS, In The Heart Of The Beast Theater production
Going solo DJ Miguel Vargas flies solo on this episode where we feature music by George Harrison, Julieta Venegas, Xuxa, Enanitos Verdes, and much much more….
Halfrican from Teenage Diaries and How the West Was Won by Lacy Roberts
Privacy Statement
© KFAI, 1808 Riverside Avenue, Minneapolis, MN 55454 Tel: 612-341-3144


text:
Arris Agrees To Buy Brocade's Networking Assets From Broadcom For $800 Million
The deal, which includes Ruckus Wireless, hinges on Broadcom closing Brocade acquisition later this year.
10 Microsoft Security Updates Rolled Out At RSA 2017
Microsoft rolled out new security features for Windows, Azure, Office 365, the SQL Platform, managed services and more at RSA 2017 as part of a pledge to spend more than $1 billion a year on security.
2017 Channel Chiefs: How Have You Personally Helped A Partner Succeed?
We asked the honorees of the 2017 Channel Chiefs to share some of their personal partner success stories. Here are 10 of our favorites.
8 Philosophical Tenets Of The Dell EMC Partner Program
The new Dell EMC partner program is underpinned by several key philosophies developed to engender partner loyalty and to stoke partner aspirations to greater earnings and status.
2017 Channel Chiefs
Check out the 2017 Channel Chiefs, CRN's annual list of the top channel execs, sortable by name or company.


text:
When parsing a full doc from a string, nsHtml5TreeOpExecutor unblocks onload an extra time and causes an assertion. Layout start and scroll to ref code unnecessary, too.
Created attachment 591715 [details] [diff] [review]
Return earlier from DidBuildModel when working for an nsHtml5StringParser
We didn't have enough DOMParser reftest/crashtest coverage to catch the assertion earlier.
Thanks for the r+.


text:
Main Menu
Sewa villa murah di puncak dengan harga terjangkau
Untuk info silahkan hubungi kami.
[SuperFiles] bald eagle recovery programs download free [f2kJ] fast
Description bald eagle recovery programs
FileName: bald eagle recovery programs
Language: ENGLISH
04/12/2015 00:23:21
Website | All Programs
Total downloads:
Windows XP/Vista/7/8 (32-Bit/64-Bit)
Download URLs
Related software:
04/12/2015 00:23:21
The bald eagle (Haliaeetus leucocephalus, from Greek hali-= sea, aiētos = eagle, leuco-= white, cephalos = head) is a bird of prey found in North America.Fact Sheet: Natural History, Ecology, and History of Recovery. pdf version . A North American species with a historic range from Alaska and Canada to northern ...Northern States Bald Eagle Recovery Plan . The Executive Summary of the Recovery Plan is provided below. Go here for a copy of the ...Learn more about eagles and see an eagle eat in a live eagle interpretive program at the National Eagle Center. View live bald and golden eagles at the NationalThe bald eagle has inspired millions of Americans across the nation since June 20, 1782. The American Eagle Day was celebrated ideally for the recovery and ...Bald eagle information, eagle photos and video, bald eagle facts sheet, where to view bald eagles, status of the bald eagleThe bald eagle, our national bird, was removed from the imperiled species list on the heels of its remarkable recovery. Here you can find information about the bald ...The American Bald Eagle Foundation and Live Raptor Center in Haines Alaska is dedicated to the preservation of our national symbolBald Eagles in California. Perilously close to extinction in the lower 48 states three decades ago, the bald eagle has made a remarkable comeback, owing to ...Bald eagle information, eagle photos and video, bald eagle facts sheet, where to view bald eagles, status of the bald eagle
bald eagle recovery programs
Most downloaded this week:
how to use paypal to collect payments
earth sounds
funzioni pdf
hentai tentacle fash games
book series in which order
jay z go crazy mp3
radeon 2900gt review
bookstores individual book printing
how to hack plants vs zombies money
superbot 4.7 serial
daiblo 2 game character patches
songs form billy ocean
sony external battery pack
game kid site web
cheats for xbox mercenaries
the last jaw
shuffle cg torrent
how to use comebacks
vst piano sounds
Teen Wolf Complete Season 3
gigabyte ga h61m d2p b3 manual
sid meiers civilization v crack
ranger programs national seashore ma
how happy mp3
Richard Clayderman - A Comme Amour (L for Love) mp3


text:
You are here
Walnut Refrigerator Sandwiches
|Softened butter
|1 Cup (16 tbs)
|1⁄2 Cup (8 tbs)
|Firmly packed brown sugar
|1⁄2 Cup (8 tbs)
|Vanilla extract
|2 Teaspoon
|Orange peel
|1 Teaspoon, grated
|1 1⁄2 Cup (24 tbs), chopped
|All purpose flour
|2 3⁄4 Cup (44 tbs)
|1 1⁄2 Teaspoon
|1⁄2 Teaspoon
Chop walnuts very fine.
Cream butter, sugars, vanilla extract and orange peel until light and fluffy.
Beat in eggs until mixture is creamy.
Stir in walnuts.
Combine flour, salt and soda; stir into creamed mixture.
Shape dough into 3 or 4 rolls 1 1/2 to 2 inches in diameter.
Roll each one in heavy-duty aluminum foil; freeze until ready to use.
When ready to bake, use sharp knife and cut dough into thin slices.
Bake on ungreased cookie sheets at 400° for 6 minutes or until lightly browned.
Cool on wire racks.
Store in airtight containers.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 4853 Calories from Fat 2555
% Daily Value*
Total Fat 295 g454.3%
Saturated Fat 129.4 g647.1%
Trans Fat 0 g
Cholesterol 911.1 mg303.7%
Sodium 3798.4 mg158.3%
Total Carbohydrates 497 g165.7%
Dietary Fiber 19.9 g79.5%
Sugars 216.6 g
Protein 73 g146.2%
Vitamin A 124.2% Vitamin C 14.6%
Calcium 41.2% Iron 128.2%
*Based on a 2000 Calorie diet


text:
Evoh High Barrier Food Packaging Plastics Bags - Chinaprice: 0.07 Dollar US$
(1)Name: EVOH High Barrier Food Packaging Plastics bags
(2)Origin: Suzhou
(3)Materials: PA;PE;EVOH
(4)Unit Price: $0.07-$0.146/pc
(5)Width: 100~650mm
(6)Thickness: 50~140um
(7)Length: per requirement ~1, 200mm
(8)Samples: Available
(9)MOQ: 2 Tons
(10)Color: Per requirement
(11)Certification: FDA
(12)Features: high shrinkage ratio, high gloss, high flexibility
Fresh meat, fish, cheese, cook-in products and other products which require high barrier to oxygen and water.
(1)Payment: 30% down payment and the balance by T/T before shipment
(2)Price Term: FOB Shanghai
(3)Delivery: 25 days after down payment
(4)Packing: Inside PE plastic bag, outside carton box
(5)Brand Name: per requirement
(6)Export Countries: All over the world
Company Contact:
- Posted By: SUZHOU GMCPACK CO.,LTD
- Phone: +86-15905196321
- Address: Room 1507,Chuangzhan Building ,No. 1500 Donghuan Road,SIP,P.R.China (Pc:215021), SUZHOU, China
- Email:
- Website: http://www.gamecapack.com
Published date: July 13, 2016 - Modified date: July 13, 2016
- Business Description: Gmcpack is a professional and innovative flexible packing manufacturer offering customers a very wide range of high barrier flexible packaging materials and one-stop solutions for food packaging. It possesses advanced 5-layer, 7-layer, 11-layer co-extrusion lines, and is capable to produce high barrier functional blow-up, blow-down and cast films with PA, EVOH and PVDC as barriers layer.
Related listings
Pvdc High Barrier Food Packaging BagsPlastic Bags - SUZHOU GMCPACK CO.,LTD - China - July 13, 2016 - 0.07 Dollar US$
PVDC High Barrier Food Packaging Bags 1.Description: With different formula and barrier material (PA, EVOH, PVDC), GB, PB and HB series bags can meet different products packaging needs that require different barrier properties. 2.Specification: (1)Wi...
Free Sample Ziplock Biohazard Specimen BagsPlastic Bags - Tongcheng Tianbai Plastic - China - July 8, 2016 - 0.02 Dollar US$
Item: biohazard specimen bags Material: virgin PE, LDPE Size: customized accepatable Thickness: 20-200 micron/layer, or as customized Style: zip lock resealable open Color: transparent, white, all colors available Logo: customized printable Printing:...
Newest Sale Machine Made Spa Liner ManufacturerPlastic Bags - Tongcheng Tianbai Plastic - China - July 8, 2016 - 4.00 Dollar US$
Item: strip pedicure spa liners Material: virgin PE/LDPE/HDPE Size (material OD): 107cm, 112cm, 122cm, 130cm, or as customized Thickness: 10 micron-16 micron, or as customized Color: transparent in common use, other colors also acceptable Rubber thre...
Safe Trade Tips
- Ask for business references and check them
- Use a payment method that offers better protection for all such as Letters of credit and verified professional escrow services. Avoid payments in advance such as money transfers
- Verify their business via their local Chamber of Commerce
- Search the internet using their website address, their business name, their phone and fax numbers, and their email addresses to see if you can find any feedback about them.
- Get to know more about scams to avoid: Internet Crime Complaint Center - International Financial Scams
- This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"


text:
Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Worldwide Shipping!
Find out more
catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP). Additionally we are shipping Thymidine Kinase 1, Soluble Proteins (100) and Thymidine Kinase 1, Soluble Antibodies (72) and many more products for this protein.
Showing 10 out of 24 products:
Human TK1 ELISA Kit for Sandwich ELISA - ABIN418493
Rapic, Vangestel, Verhaeghe, Thomae, Pauwels, Van den Wyngaert, Staelens, Stroobants: Evaluation of [(18)F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer. in Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2016
Mouse (Murine) TK1 ELISA Kit for Sandwich ELISA - ABIN824872
Shi, Sun, Li, Zhao, Ju, Mu, Yan, Li, Zeng, Lu: A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer. in Journal of biomedical nanotechnology 2015
The down-regulation of Tk1 activity unmasks Tk2 deficiency in Tk2-/- mice and correlates with the onset of mtDNA depletion in the brain and the heart.
blood cells are less dependent on mitochondrial Tk2 compared with several other tissues; these cells can synthesize deoxyribonucleotides required for mtDNA replication by alternative pathways such as phosphorylation of thymidine by cytosolic Tk1
Mutations in the TK1 gene were studied in neonatal transgenic mice treated with AZT.
the small colony mutant phenotype in L5178Y lymphoma is not caused by deletion of both Trp53 (show TP53 ELISA Kits) and thymidine kinase 1
STK1 (show CDK7 ELISA Kits) is a reliable biomarker for discovering people with malignant tumors in cancer screening.
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver
TK1 expression is significantly different in invasive urothelial carcinoma and benign urothelium, which underlines its potential as a diagnostic marker
Protein expression of BIRC5 (show BIRC5 ELISA Kits), TK1, and TOP2A (show TOP2A ELISA Kits) in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.
High Thymidine Kinase expression is associated with adenocarcinoma in Non-small Cell Lung Cancer.
These results demonstrate that there are differences in the specific activities and the subunit compositions of STK1 (show CDK7 ELISA Kits) in hematological malignancies compared with breast and prostate cancer.
A regression analysis showed that only TK1 levels were significant (relative risk (RR)=1.03 for each unit, confidence interval (CI)=1-1.05; p=0.015) for diagnosing a true transformation
We suggest that a chip including DPYD (show DPYD ELISA Kits), TYMS (show TYMS ELISA Kits), TYMP (show TYMP ELISA Kits), TK1, and TK2 genes is a potential tool to predict response in LARC (show CCL20 ELISA Kits) following fluoropyrimidine-based CCRT.
Nuclear TK1 expression in early grade cervical intraepithelial neoplasia predicts risk for progression to malignancy
3'-deoxy-3'-[18F]-fluorothymidine (18F-FLT (show FLT1 ELISA Kits)) kinetics correlates with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas
catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP)
deoxyribonucleoside kinase
, thymidine kinase, cytosolic
, thymidine kinase 1, soluble
, thymidine kinase 1
, Thymidine kinase, cytosolic
, thymidine kinase
, thymidine kinase 1 soluble isoform
, thymidine kinase-1


text:
Top Definition
The Sean Nine is used in cases of texting, IMing or E-Mailing. It is used to clearly state an obviously sarcastic statement. To use the Sean Nine, simply put the numerical form of a nine (9) at the beginning and closing of the sarcastic statement.
Oh my, 9the Sean Nine is so uncool.9
by stugilligangriffin May 03, 2009
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


text:
BBOOTS™ Is The First And Only Fully Responsive phpBB® Unofficial HTML5/CSS3 Theme Built Entirely from the GROUND-UP. It's Clean And Crisp Design Looks AWESOME Across All Browsers And Devices. Based on Bootstrap Framework is sure to AMAZE the phpBB Fan Club…
BBOOTS 3.0.3 released on Nov 13, 2014
BBcore Update: Now including a default offline board page and the fantastic Gravatar addon! (marketplace.php?mode=view&item_id=2) -The gravatar is off by default. This can be enabled via ACP > Avatar settings > Enable gravatar: YES
Bootstrap updated to 3.3.1
Jquery Cookies updated to 1.4.1