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Sequential occurrence of skin symptoms and transepidermal water loss (TEWL) changes. Arrows indicate the approximate onset of changes. Data are pooled from all patients with marked interindividual differences.
Comparison of pretreatment and maximum transepidermal water loss (TEWL) readings during irradiation in each individual patient. In 12 of 15 patients an increase of TEWL was observed (P<.05). Measurements from erosive skin changes were excluded from the analysis.
Duration of skin symptoms in patients with onset of transepidermal water loss (TEWL) increase at less than 10 days after the initiation of radiation therapy compared with patients with onset at more than 10 days (P<.01).
Schmuth M, Sztankay A, Weinlich G, Linder DM, Wimmer MA, Fritsch PO, Fritsch E. Permeability Barrier Function of Skin Exposed to Ionizing Radiation. Arch Dermatol. 2001;137(8):1019-1023. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-137-8-dst10025
© 2017
To characterize the epidermal permeability barrier function of skin during exposure to ionizing radiation.
A prospective cohort study.
University hospital medical center.
Fifteen women receiving local radiation therapy (5000-6000 rad [50-60 Gy]) following breast-conserving surgery for breast cancer.
Main Outcome Measures
Clinical symptoms and transepidermal water loss (TEWL).
Epidermal permeability barrier function is impaired in patients who exhibit clinical signs of radiation dermatitis. The functional damage to the stratum corneum induced by ionizing radiation occurs with a delayed course, starting within a mean period of 11 days and reaching maximal values after a mean period of 27 days (range, 13-75 days). The onset of TEWL increase precedes the onset of radiation dermatitis and the maximal TEWL measurements precede the peak of skin changes. Patients with an early onset of TEWL increase show a longer duration of skin symptoms.
Skin changes caused by radiation dermatitis are associated with an increase in TEWL. The barrier impairment is comparable to the changes observed with UV radiation exposure but exhibits an even more delayed course. Our results suggest that preservation of the epidermal permeability barrier function by topical treatment may ameliorate radiation dermatitis.
THE SKIN IS A protective barrier against a variety of physical and chemical insults from the environment, including mechanical forces, natural and man-made toxins, extreme temperatures, low-voltage electric current, and electromagnetic radiation such as UV and ionizing radiation. The epidermal response to external injury has been well documented and is aimed at the maintenance of epithelial homeostasis.1,2 The latter is accomplished by a tightly regulated process of epidermal keratinization and differentiation.3,4 The end product of this process is the outermost sheath of the skin, the stratum corneum, consisting of protein-rich corneocytes embedded in a continuous, lipid-rich, intercellular matrix.2 This layer mediates the barrier properties of the skin, allowing for control of body fluid loss in an arid terrestrial environment and protection from physical and chemical external assault.
Cutaneous barrier function can be assessed quantitatively using bioengineering techniques, such as measurement of transepidermal water loss (TEWL), which has been proven valuable for the quantitation of external assaults to the skin.5- 7 With this technique, impairment of the permeability barrier function in consequence of mechanical (ie, tape stripping) or chemical (ie, acetone, detergents) assault to the stratum corneum can be directly monitored.8 Recently, UV-B irradiation of murine skin has been shown to disrupt barrier homeostasis with a delayed course.9 In this study, we assessed TEWL in patients undergoing radiation therapy, because ionizing radiation is known to directly interfere with differentiation in the epidermis10 and the clinical appearance of irradiated skin bears similarities to a number of other skin conditions with impaired epidermal permeability barrier function (Table 1).11
Female patients receiving radiation therapy for breast cancer were eligible for the study after completing routine staging procedures and giving informed consent. The study was approved by the local ethics committee. The Karnofsky index as measure of the patient's overall neurological condition had to be greater than 70 in all patients to exclude bias due to general health deterioration. Further exclusion criteria were previous radiation therapy or radiation dermatitis; preexisting skin conditions, including atopic dermatitis, psoriasis, or ichthyosis; diabetes; as well as topical and/or systemic corticosteroid use during the 2 weeks before initiation of radiation therapy. Of the 26 patients who were initially approached, 9 refused to participate, and 15 of the 17 enrolled patients completed the study. Their median age was 57 years (mean, 55.4 years; range, 29-75 years), and their cancer stages were T1-3 N0-2 M0-1. Three patients demonstrated metastases to the axillary lymph nodes and/or to the sternal or supraclavicular region. Seven patients received adjuvant chemotherapy either before or after radiation therapy but none during radiation therapy or TEWL measurements. Patient characteristics are summarized in Table 2.
Twelve patients (T1-2 N0 M0) received tangential field irradiation to the breast and chest wall following breast-conserving surgery by external beam using photons (8 MV). One of these patients received an additional boost to the tumor bed using electrons (14 MeV). The 3 patients with metastases (T1-3 N1-2 M1) underwent mastectomy and received a combined radiotherapy of photons and electrons, including the sternal and/or supraclavicular region, respectively. The radiation was generated by a linear accelerator (Philips SL 20; Philips Electronics UK Limited, Crawley, England). Total doses ranged from 5000 to 6000 rad (50-60 Gy), which were applied in single fractions of 20 rad (2 Gy) 5 times a week.
Clinical symptoms were assessed qualitatively according to the following parameters: erythema, desquamation, erosion, hyperpigmentation, and induration. Transepidermal water loss was measured for 4 test areas (1.3 cm2 each) within the radiation field of the breast (1 site per quadrant) and on a control area of the nonirradiated, volar aspect of the forearm. Transepidermal water loss was recorded in grams per square meter per hour using a Servomed Evaporimeter (Stockholm, Sweden).12 The probe was handled with a clamp to avoid heating and applied parallel to the skin surface under a closed box with an open top to protect the measurement zone from excess air convection. Transepidermal water loss values were registered after equilibration of the probe on the skin (>60 seconds). Relative humidity, atmospheric pressure, and room and skin surface temperature were monitored along with the TEWL data recorded to ensure comparability of the environmental conditions.13 Measurements were taken before radiation therapy and biweekly during therapy (total time, 5-6 weeks). In 11 of 15 patients, additional follow-up measurements were taken every 2 weeks for 4 to 8 weeks after completion of radiation therapy. To calculate deviations of measurements from pretreatment baseline values, expressed as percentages, the following formula was used:
{[(TEWLirradiation area at indicated time/TEWLcontrol area at indicated time)/(TEWLirradiation area before irradiation/TEWLcontrol area before irradiation)]−1}× 100%.
The maximal TEWL value from 4 test sites was used for each time point. In cases of severe cutaneous reactions, routine topical regimens for radiation dermatitis were used, including topical emollients, corticosteroids, and wound dressings. However, no topical treatment was allowed for at least 8 hours before TEWL measurements. When skin erosions occurred (6 patients), permeability barrier function was not quantitated because of exceptionally high TEWL values (up to 25-fold increase).
Pretreatment and posttreatment measurements of TEWL were compared using the t test for paired measurements; P ≤ .05 was considered statistically significant.
Clinically, human skin is known to exhibit erythematous changes after exposure to ionizing radiation. A distinction between immediate and typical erythema (after several weeks of repeated exposure) has been made.14,15 Four of our 15 patients exhibited an immediate erythema (24-hour erythema), which arose within a few hours after irradiation and subsided within 3 to 4 days. Fourteen of 15 patients developed a typical radiation erythema, which set in after a mean interval of 23 days (median, 22 days; range, 6-37 days) and lasted for an average of 22 days (median, 20 days; range, 6-45 days). In 1 patient, an immediate and a typical erythema were followed by an additional late erythema (onset at day 38, duration of 10 days). Six patients developed skin erosions, which started after a mean period of 37 days after onset of irradiation (median, 43 days; range, 27-68 days). Desquamation was observed in 3 patients after a mean period of 61 days (median, 49 days; range, 21-65 days) and hyperpigmentation in 8 patients after a mean period of 57 days (median, 60 days; range, 46-91 days). Figure 1 illustrates the sequential onset of skin findings in our group of patients. Most patients had 2 or more types of these reactions, but 1 patient did not develop any signs of radiation dermatitis. Clinical signs of radiation dermatitis were limited to the irradiation field. All patients exhibited subcutaneous induration of the irradiated skin of variable degree, beginning approximately 3 weeks after initiation of radiation therapy. Associated symptoms included transient pruritus or burning sensations. Six patients required topical therapy because of the severity of skin symptoms after 4 to 5 weeks, which consisted of topical corticosteroids in 4 patients. Because of the small number of patients in this subgroup, no separate analysis was possible.
Twelve of 15 patients showed an increase of TEWL during radiation therapy. Changes in TEWL started within a mean period of 11 days (median, 8 days; range, 4-26 days). Transepidermal water loss values increased to a mean maximum of 2-fold over pretreatment measurements (mean, 11.8 g/m2 per hour). Pretreatment values compared with the maximum TEWL readings during irradiation are shown for each individual patient in Figure 2. Maximal measurements were reached within a mean period of 27 days (median, 25 days; range, 13-75 days) after the onset of radiation therapy. Readings were significantly increased compared with pretreatment values (P = .04, Figure 2). Follow-up measurements were performed in 11 patients after completion of radiation therapy. In this group, TEWL decreased to baseline values within a mean of 66 days (median, 62 days; range, 34-86 days) after onset of therapy.
Increases of TEWL were associated with the occurrence of clinical symptoms (ie, erythema, desquamation, erosions). They did not correspond, however, to the biphasic course of erythema. The onset of TEWL increase (after a mean period of 11 days) preceded the onset of radiation dermatitis (mean, 22 days). Patients with an early increase in TEWL (<11 days after initiation of radiation therapy) reached higher maximal TEWL readings during radiation dermatitis; this difference, however, was not statistically significant (data not shown). The duration of skin symptoms was longer in the group of patients with an early TEWL increase (Figure 3). Maximal TEWL increases were observed only when clinical signs of radiation dermatitis were present, but maximal TEWL (mean, 27 days) preceded the peak of the skin changes (mean, 35 days; P<.05). Increases in TEWL were most accentuated in the lower medial quadrant of the breast and the intertriginous areas, including the submammary and axillary folds.
Radiation dermatitis is a common and dose-limiting adverse effect of radiation therapy.15,16 Its course and severity are known to depend on both total dosage and fractionation.17,18 Today, conservative surgical strategies for breast cancer, breast-conserving combined with postoperative irradiation, when correctly performed, can provide results as effective as the more invasive surgical strategies used in the past. Although the skin is not the primary target of ionizing radiation in most cases, exposure of the skin is inevitable. During radiation therapy for breast cancer, the skin is exposed to significant doses of radiation to treat a maximum number of potential, subclinical tumor remnants.
We evaluated the effect of ionizing radiation on epidermal permeability barrier function in a clinical setting by monitoring TEWL values during radiation therapy for breast cancer. Our data demonstrate that radiation therapy for breast cancer is associated with impaired epidermal barrier function. The barrier abnormality induced by ionizing radiation displays inherent differences from other models of barrier abrogation. Mechanical or chemical disruption of the barrier is associated with an immediate barrier defect due to removal of extracellular lipids from the stratum corneum. In contrast, the barrier abnormality induced by ionizing radiation is delayed as has earlier been reported for UV-exposed skin.9 The delay in barrier impairment caused by ionizing radiation (mean onset, 11 days after irradiation; maximum after a mean of 27 days as opposed to 72 hours after UV exposure) may be explained by the facts that the biological tissue reaction to ionizing radiation in general occurs more slowly and that in radiation therapy for breast cancer a considerable amount of ionizing radiation is aimed at deeper, subcutaneous anatomical structures. For ethical reasons, skin biopsy specimens were not obtained from the cancer patients enrolled in the present study. However, the published histological data on radiation dermatitis describe perivascular inflammatory infiltrates around dilated blood vessels with swollen endothelial cells14,19 and degenerative changes of the epidermis with epithelial cell death and hypoplasia.10 Data from the mouse model indicate that ionizing radiation inhibits proliferation and mediates apoptosis in the epidermis by inducing damage to the DNA.10 Moreover, for UV-exposed skin, ultrastructural observations are available, showing the outward migration of a band of lamellar body–deficient keratinocytes, which is associated with abnormal extracellular bilayer formation and a delayed increase in epidermal lipid production.20
The inflammatory reaction, which can be observed clinically and histologically, may be a direct effect of the ionizing radiation on the dermis. The involved inflammatory mediators may reach the epidermis by diffusion, causing additional impairment of epidermal differentiation and barrier function. However, recent work by Trott et al10 in the mouse model has questioned a causal relationship between dermal inflammation and epidermal proliferation or differentiation in radiation dermatitis, because prior treatment with indomethacin did not suppress and prior UV-B exposure did not accelerate (by inducing inflammation) epidermal repopulation. On the other hand, the inflammatory reaction may be secondary to the barrier defect, which itself is known to induce cytokine secretion and may in turn cause fibrosis within the underlying dermal tissue21 (explaining the very common fibrosis after irradiation).
Although the functional assessment presented herein does not allow distinguishing whether the barrier impairment associated with radiation dermatitis is of primary or secondary nature (Table 1), it seems likely that our observation has clinical implications. In fact, this can be tested by the application of topical formulations to radiation dermatitis, since lipid mixtures have been shown to accelerate barrier repair.22 Clinically, radiation dermatitis is assessed by visual inspection and palpation. Noninvasive bioengineering techniques have been used for more accurate evaluation. Most of these techniques have been designed to quantitate erythema using colorimetry, spectrophotometry, or laser Doppler imaging.23,24 Stromal reactions that are not visible to the eye primarily have been assessed using 20-MHz ultrasonic imaging or dielectric methods.25,26 In contrast, our data obtained by evaporimetry provide evidence for damage to the most superficial layer of the skin, the stratum corneum, which can be easily accessed for therapeutic intervention. Thus, application of topical therapeutic agents to the skin might be useful for prophylaxis or therapy of radiation dermatitis and might be monitored by the experimental setting used in this study.
Accepted for publication January 18, 2001.
Presented at the International Investigative Dermatology Meeting, Cologne, Germany, May 7, 1998.
Corresponding author: Matthias Schmuth, MD, Department of Dermatology, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria (e-mail: firstname.lastname@example.com).


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Public Philosophy in a New Key: Volume 2, Imperialism and Civic Freedom
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Public Philosophy in a New Key: Volume 2, Imperialism and Civic Freedom by James Tully
Book DescriptionThese two ambitious volumes from one of the world's most celebrated political philosophers present a new kind of political and legal theory that James Tully calls a public philosophy, and a complementary new way of thinking about active citizenship, called civic freedom. Professor Tully takes the reader step-by-step through the principal debates in political theory and the major types of political struggle today. These volumes represent a genuine landmark in political theory. In this second volume, Professor Tully studies networks and civic struggles over global or imperial relations of inequality, dependency, exploitation and environmental degradation beyond the state. The final chapter brings all of the author's resonant themes together in a new way of thinking about global and local citizenship, and of political theory in relation to it. This forms a powerful conclusion to a major intervention from a vital and distinctive voice in contemporary thought.
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Two ambitious volumes from one of the world's leading political philosophers presenting a new kind of political and legal theory.
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Two ambitious volumes from one of the world's leading political philosophers presenting a new kind of political and legal theory.
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Email: firstname.lastname@example.com
Jay Crutchfield, MD, FACS, a native of Arizona, joined the teaching faculty of SOMA in June, 2010. Dr. Crutchfield, a board-certified general surgeon, received his bachelor of arts degree in Chemistry from the University of Arizona, a doctorate in medicine from the Mount Sinai School of Medicine (New York, NY). He is a former member of the Arizona Medical Board (appointed by Governor Hull), and the Arizona Regulatory Board of Physician Assistants (appointed by Governor Jan Brewer).
At SOMA, Dr. Crutchfield will join the anatomy faculty and developing the surgery curriculum. In his spare time, he enjoys astronomy, astrophotography, and collecting rock n' roll memorabilia.


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Chills, Thrills and Hardcovers
Shiver. Hmm, that's something we've been doing a lot of. Flu shot be damned, we acquired a lovely affliction sometime last week that keeps us bobbing between sweaty hot flashes and, well, shivers. Fortunately, Lisa Jackson's new romantic thriller, Shiver, isn't about colds, flu-like symptoms or lying around and groaning to one's empty apartment (Admit ityou do it too.). Call us crazy, but we aren't champing at the bit to read about post-nasal drip; we just want it to stop. Her latest release is about a murder spree in New Orleans, a detective on the gruesome trail and Abby Chastain, a photographer with one helluva porn name. Will they catch the killer? Will they have to go deep into the bowels of a condemned insane asylum to solve the case? Why is a portrait photographer on the case anyway? Sounds like a perfectly campy cure for S.I.B. (Seasonal Illness Boredom). Jackson signs her first book to be published originally in hardcover 2 p.m. Sunday at Waldenbooks, 1101 Melbourne Road in Hurst. Call 817-589-1021.
Sun., April 9, 2 p.m.
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2010 Scouting Report: Enters his first active season at Pitt following a 2009 transfer from Virginia...will provide immediate help at tight end, a position the Panthers will be retooling this year following the departures of NFL Draft selections Dorin Dickerson and Nate Byham...excellent size and smarts.
2009: Did not play in any games under NCAA transfer guidelines.
At Virginia (2007-08): Lettered in 2008, playing in all 12 games and starting two...had three catches for 22 yards (7.3 avg.) on the year...had a career-high two catches for 16 yards in a starting assignment vs. East Carolina...other reception was a six-yarder against Maryland...also made a start against North Carolina...moved to defensive end near the end of the '08 campaign...redshirted as a true freshman in 2007.
High School: Heralded tight end prospect at Mt. Lebanon...rated the nation's No. 11 tight end by Scout, No. 14 by Tom Lemming and No. 22 by Rivals...rated Pennsylvania's No. 13 overall prospect by Rivals, No. 16 by Scout and No. 19 by SuperPrep...PrepStar All-East Region...named to The Associated Press Pennsylvania Class AAAA All-State Team (second team)...Pittsburgh Post-Gazette "Fabulous 22"...a two-way standout at Mt. Lebanon under Coach Chris Haering...had 60 tackles, 11 tackles for loss and two sacks as a senior...also had nine receptions for 118 yards and two touchdowns...selected to play in the prestigious Big 33 Football Classic...a 1,000-point career scorer in basketball...averaged more than 15 points per game as a junior to lead Mt. Lebanon to the WPIAL Class AAAA championship.
Personal: Andrew Charles Devlin, born 10/14/88, is the son of Bridgetta and Timothy Devlin...has one brother and one sister...business-finance major.
Three Pitt Student-Athletes Selected to Receive ACC Postgraduate Scholarships
Charlie Partridge Rejoins Pitt as Defensive Line Coach
Pitt Places Six on All-ACC Academic Football Team
Conner Named Maxwell Football Club's Brookshier Spirit Award Recipient
Pitt Duo Among New England's Super Bowl Champions
Pitt Great Larry Fitzgerald Named NFL Man of the Year


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79th Texas Legislature, Regular Session, House Bill 843, Chapter 945
Description: Bill introduced by the Texas House of Representatives relating to the authority of certain counties to regulate communication facility structures in certain circumstances; providing a penalty.
Date: June 18, 2005
Creator: Texas. Legislature. House of Representatives.
Item Type: Legislative Document


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More Videos...
How Much Water Can A Model T Pass Through?
Steven Lang driving his 1926 Model T Speedster across a swamp on Stoney Pass 4x4 Trail
Tandem Axle Model T Ford
Here's a real neat Model T Ford with an aftermarket tandem axle modification. Wauseon, Ohio 2008.
1896 Henry Ford´s Quadricycle replica
The first ford car replica made in Spain. Visit http://www.quadricycle1896.com http://www.tecnomaquinas.es (nuestra tienda de maquinaria para el aficionado)
1925 Ford Model T First Start
1925 Ford Model T Coupe This Model T was a Connecticut 'barn find' in April 2012, and had been sitting since 1976. The car is all original and unrestored and will be kept as a "driver" in its original condition. Music Credit: Theme song from Click and Clack: The Tappet Brothers radio show on NPR.


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Cisco Unified IP Phone 7942G. Colour of product: Grey. Dialer location: base. Display: LCD, Display resolution: 320 x 222 pixels, Display diagonal: 12.7 cm (5"). Power requirements: 48V DC. Compliance industry standards: DSCP, 802.1Q/p
The Cisco Unified IP Phone 7942G is a full-featured IP phone with speakerphone and handset designed for wideband audio. It is intended to meet the needs of needs of transaction-type workers with significant phone traffic. It has two programmable backlit line/feature buttons and four interactive soft keys that guide you through all call features and functions. The phone has a large, 4-bit grayscale graphical LCD that provides features such as date and time, calling party name, calling party number, digits dialed, and presence information. The crisp graphic capability of the display allows for the inclusion of higher value, more visibly rich Extensible Markup Language (XML) applications, and support for localization requiring double-byte Unicode encoding for fonts. A hands-free speakerphone and handset designed for hi-fidelity wideband audio are standard on the Cisco Unified IP Phone 7942G, as is a built-in headset connection and an integrated Ethernet switch.The Cisco Unified IP Phone 7942G is designed to grow with your organization and enhancements to your system capabilities. The dynamic feature set allows the phone to keep pace with your requirements through regular software updates. Firmware changes can be downloaded from Cisco.com. No hands-on moves and changes are required with the phone-you can simply pick up the phone and move to a new location anywhere on your network. The Cisco Unified IP Phone 7942G also provides many accessibility features.


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Chat with Dan Graziano
Welcome to SportsNation! On Tuesday, ESPN.com NFC East blogger Dan Graziano stops by to chat about the league.
Graziano joined ESPN.com in 2011 after two years as a Senior NFL Writer for AOL FanHouse. He covered Major League Baseball, the Olympics and various other sports during his time at the Star-Ledger and the Palm Beach Post. A New Jersey native and author of two published novels, he now lives in Ridgewood, N.J., with his wife and two sons.
Send your questions now and join Graziano Tuesday at noon ET!
More Dan Graziano: Chats | Search | NFC East blog | @DanGrazianoESPN
Dan Graziano (12:00 PM)
Hello, all. What's on your collective mind?
Peter (Sao Paulo)
I keep reading comments about how dire the Redskins cap situation is. I would like to know if you consider it worse than their situation last year. It seems to me that only a couple of their FA's are essential, and last year they were able to fill some crucial slots with decent players. Is this year going to be worse than last year? How much can we afford to spend on FA RT's, Safeties, and CB's and who might be available at those prices? Thanks!
Dan Graziano (12:01 PM)
If I remember last year correctly, even once the penalty hit, the Redskins were still under. I don't recall the exact numbers, but for example, if they were $27 million under before the penalty hit, they were then only $9 million under, so it affected them but not too badly. This year, they're actually projecting over the cap by about $3 million or $4 million, so they have to cut or restructure some people before they even think about hitting the market. Last year, the penalty hurt them, but they still knew they'd have enough to sign Pierre Garcon.
chris (Rochester)
Dan do you see the Eagles possibly trading back from the #4 spot if some team wants Milliner enough, and what do you think the package would have to entail? This would be a situation like the cowboys did last year with morris claiborne as they traded away a 1st and 2nd round pick to the Rams.
Dan Graziano (12:02 PM)
It's not a bad idea in theory. If the team picking, say, eighth, wants to give you that pick and a second-rounder for the No. 4, that's enticing. But my hunch is that there'll be a player the Eagles really like at 4, and they'll sit tight and take him.
Alex (Anaheim)
I noticed Antrel Rolle showed up on ESPN's worst value for cap hit list. Do you expect a better year from him next season?
Dan Graziano (12:04 PM)
How about that? One of the two safeties and both corners on that team were NFC East players. Secondary play in this division is a mess. As for Rolle, I think he's a better player when Phillips is on the field, since Phillips can play deep and let Rolle crowd the box or vice-versa. I think Rolle's limitations show up more when Phillips isn't on the field, and Phillips missed a lot of time last year. If he's not back, I think Rolle could struggle again.
BKW (Mount Airy)
Now that the Boys have tagged Spencer, what do they do with their 1st round pick? OL, S, or trade down for an additional pick? Needs are plentiful this year, as a fan I wouldn't mind seeing the last option if they could pick up another 2nd or 3rd rounder.
Dan Graziano (12:05 PM)
Offensive line, offensive line, offensive line. If the Cowboys don't take an offensive lineman in the first round, Cowboys fans have my permission to give up hope. The ONLY reason it MIGHT not have made sense to go OL was that DL was an arguably bigger need. But with Spencer tagged, that argument is off the board. They absolutely, 100 percent, no doubt about it need to pick an offensive lineman in the first round.
Jason (Russell, MA)
Dan, I realize that the Giant's situations with Diehl and Webster are a bit tricky because of depth at their respective positions, but are you still a little surprised that there hasn't been any moves at this point by New York to try and get some of that 16 million in cap space back from those two?
Dan Graziano (12:05 PM)
Not really. They're under the cap, so there's no urgency. Makes more sense to make sure you have your backup plan in place before creating a hole.
Andrew (Dallas)
Why can't the Redskins write contracts for their FA with the understanding that they will have an extra $18 million next season?
Dan Graziano (12:06 PM)
I keep getting this question, and I don't understand it. They don't get an "extra $18 million next season." They'll have the same salary cap everyone else will, and they already have guys signed for next season.
Andrew (DC)
More likely to happen: Skins get cap space back or they change their name?
Dan Graziano (12:06 PM)
Name change.
David (Halifax)
With so much cap space, the obvious need for corners AND Marty Mornhinweg now in NYJ, you see any likelihood that Howie goes for Revis in some sort of Foles trade?
Dan Graziano (12:07 PM)
I don't think they're trading Foles, but I could see them getting Revis for picks, sure
mike (philly)
Do you see the cowboys addressing Safety in FA or the draft? Or do you think Matt Johnson and Church will be the starters?
Dan Graziano (12:08 PM)
I think they'll get someone, either in FA or the draft. No way to count on Johnson at all for anything, and Church is coming off a serious injury
Andrew (Dallas)
The Redskins will have $18 million more next year than this year. Shouldn't most of that be available still, or do their contracts already go up?
Dan Graziano (12:11 PM)
Lots of them go up, as most contracts do. Garcon goes up by 1.6M, Trent Williams by 3.0M, Carriker by 2.0M...
Josh (Syracuse, NY)
Can the Giants afford to lose the coverage skills of Phillips? Already struggle in secondary, and Stevie's INTs are nice but I would rather stop giving up the deep ball.
Dan Graziano (12:12 PM)
I think the dropoff from Phillips to Brown is being obscured by Brown's ridiculous INT total, which is unlikely to repeat itself. I believe they will miss Phillips a lot, and I believe they did in 2012.
Matt (Rhode Island Eagles)
The whole story of the Eagles asking for Asomugha to restructure his contract was about 2 weeks ago, do you think its taking long because they are actually trying to make a deal? So many talking heads still think he's gone.
Dan Graziano (12:13 PM)
The Eagles are $33M under the cap. They don't HAVE to do anything. They can wait and see who else is out there and signed before decided what to do about Asomugha. They have missed no significant deadline for restructuring or releasing him.
Gary (New York City)
Dan, now that the Giants have re-signed Will Beatty (which I am thrilled about), what do you suspect their next priority is? Kevin Boothe? Victor Cruz? Free agency? Any inside scoop as to Jerry Reese's priorities right now?
Dan Graziano (12:13 PM)
I'm thinking maybe a Nicks deal, maybe some CB help.
Hanson (DC)
What is the biggest changes the Eagles will have to make up front to run Kelly's offense?
Dan Graziano (12:14 PM)
Honestly? They have to cut down on the turnovers.
Joe (CT)
Is a cruz deal coming or do you see them letting him walk after this years tender?
Dan Graziano (12:15 PM)
My gut feeling is that they'll eventually get it done. He doesn't want to leave. The off-field opportunities in NY for him are unparalleled, and he knows that. They'll likely get him at something close to their price.
george (omaha)
Is Bennett an average tigh end? Was his output better in NY then in Dallas b/c he started or did he actually play better in NY?If Bennett equates money with respect for his skills, what will he do?
Dan Graziano (12:16 PM)
I think he's an above-average blocker with above-average physical gifts who has, so far in his career, been an average receiver.
Danny (Texas) [via mobile]
What do you think of Flaccos deal? Is he worth that kind of money?
Dan Graziano (12:16 PM)
Timing is everything in this world, Danny.
Hanson (DC)
Dan I think you didn't see the up front part of the question.I am wondering what changes they need to make in the type of O-lineman they need for his offense to be effective.
Dan Graziano (12:18 PM)
Oh. Well, first of all, I really don't think we know much about what his offense is going to look like at the pro level. I know a lot of people think they do, and talk as though they do, but I don't think anyone really does. Second of all, Jason Peters, Evan Mathis and Todd Herremans can play in any scheme. I think all the Eagles need to do is get their linemen healthy, maybe add a big monster tackle at the top of the draft, and they'll be fine.
Lee (DC)
I agree with you when you say you can't see how the Cowboys will pick anything else but OL in the first round. Do you have the same feeling about a position for the Redskins pick in the 2nd rd? Mine is best DB available.
Dan Graziano (12:18 PM)
I would agree that that's their biggest need.
Phil (Florida)
Vick=Tebow, care to reconsider?
Dan Graziano (12:19 PM)
No one who's ever seriously watched them both throw could say that with a straight face.
Kung Fu (Panda)
With Sensabaugh getting cut, do you see Dallas targeting a safety in the first round?
Dan Graziano (12:19 PM)
No. Why? Because Sensabaugh was so irreplaceable that they need a first-round safety? Offensive line. Offensive line. Offensive line.
Tino (Mexico)
What's the point of cutting Doug Free by June 1st if they can't use the cap space this season? I mean all the good FAs will be gone by then
Dan Graziano (12:20 PM)
You can carry unused cap space into next year. And with the way the Cowboys restructure deals, they could use it
guinness0224 (NY)
Colin Cowherd is doing a March Madness bracket with the 64 best quarterbacks ever duking it out. Any chance of getting you to do one with the best players all time in the NFC East?
Dan Graziano (12:20 PM)
But we know who the winner will be.
Tommy (NOLA)
which nfc east team would be most likely to draft tyrann mathieu
Dan Graziano (12:21 PM)
The one that still has him atop their draft board when their fourth-round pick rolls around?
DLloyd (Arlington, VA)
There are some rumors Fred Davis might not be getting multi-year deals from other teams due to Achilles injury (though his rehab appears to be going well), and some insiders seem to think he might be bought for as little as a 1 year, $2 million contract. Any thoughts on Fred? Odds of re-signing if that number is a reasonable ballpark?
Dan Graziano (12:21 PM)
If he'll sign for that, I imagine he'll be a Redskin.
guinness0224 (NY)
Lawrence Taylor?
Dan Graziano (12:21 PM)
Of course.
Midge (Scranton)
Dan I'm not sure how you feel,could the Cowboys use an offensive lineman or two?
Dan Graziano (12:22 PM)
Honest to god, did anybody but me watch them last year? Off. Ens. Ive. Line!!!!!
Kung Fu (Panda)
Ok. So Lets say Dallas goes with Cooper in the first round. Does dallas then target a guy like Elam to fill the hole at safety?
Dan Graziano (12:22 PM)
I don't know. Maybe. Sure. If you guys want to draft a safety so badly, sure, Elam. But I don't think they'd be crazy to take OL with that pick too.
Chris (Philly)
There are some other good ones...Emmitt, Reggie,
Dan Graziano (12:23 PM)
Quite a number of very good ones. But only one LT.
rawz (kansas)
So your telling me, your the cowboys GM, and its your pick, and on your board, the scouts have the safety, and a defensive lineman rated higher then any offensive lineman still on the board, you still reach and take an offensive lineman?
Dan Graziano (12:24 PM)
Mel Kiper has six offensive linemen in his top 25. No one has to reach.
Marc (Malden, MA)
Would you really wait until the 4th round to draft Tyrann Mathieu? He seems like a 1st round talent who is dropping just because he smokes pot. I hope the Skins don't care about that and get him in 2nd.
Dan Graziano (12:25 PM)
I have not heard one single draft analyst or expert say he's a first-round talent.
Kev (NYC)
So you're saying the Giants won't cut Diehl or Webster if they don't have to?
Dan Graziano (12:25 PM)
I'm saying, in answer to questions about what's taking so long, that they're in no hurry to do so in the absence of replacements.
Kung Fu (Panda)
Ok. If dallas is THAT crazy for o-line in this draft. How in the heck do they fill the void left at strong safety? Free agency perhaps? i think not. Dallas hasn't had a reliable safety of any caliber since Darren Woodson. They need to get a top notch safety in the first three rounds. There is a TON of depth in the o-line department.BEND TO MY WILL, DAN!
Dan Graziano (12:27 PM)
I don't but this depth argument. They don't need AN offensive lineman. They need A VERY GOOD offensive lineman. Who cares about the depth? Get one of the top five guys.
Ray Finkle (Miami)
What are your thoughts on Kenny Phillips going to the Eagles? NY didn't franchise him and the Eagles have plenty of cap space and knowledge of his skills. Only downside could be health. Your thoughts good sir?
Dan Graziano (12:28 PM)
The only downside with Phillips is health. Every single team in this division could use Phillips, as could many others around the league. Now, part of the reason the Giants may let him go is if they think his knee is bad and won't get better. And if that's the case, that's a shame and obviously reduces his value. But if he's on the field, he'd make the Eagles, Cowboys, Redskins, Giants or anyone else better instantly.
Leon Kiing (SE.GA)
What happens first: Dallas wins Super Bowl or Jerry Jones appears as a super-villain in a James Bond movie?
Dan Graziano (12:28 PM)
That last thing hasn't happened yet????
Bill (AC,NJ)
So DJ Fluker, Vaccaro, Cooper available at 18 what is your pick?
Dan Graziano (12:28 PM)
Jeremy (Troy, NY)
Do you think that the Giants will try to work out an extension with Manning to help alleviate some of the cap burden previous restructures have laid upon them?
Dan Graziano (12:29 PM)
I doubt it. Eli's cap numbers the next couple of years are already very, very high. Pushing big dollars back into his decline years seems like a mistake
Brian (Philly)
Do you foresee anything new being announced (re-signings, personnel moves,...team relocations) before free agency starts next week?
Dan Graziano (12:30 PM)
Well, the Redskins are going to have to get under the cap. There will be Redskins news before next Tuesday.
Red (Tyler)
Does the tagging of Spencer make it even more important to extend Romo with a more cap friendly deal ?
Dan Graziano (12:30 PM)
Gary (New York City)
Dan, going off on a tangent a little bit, i am STILL stunned that the Giants beat the 49ers 26-3 and the Packers 38-10 and missed the playoffs....
Dan Graziano (12:31 PM)
The Giants' collapse stunned a lot of people. Myself included. They always seem to surprise me, those Giants.
Andy (Pompano Beach, FL)
"I doubt it. Eli's cap numbers the next couple of years are already very, very high. Pushing big dollars back into his decline years seems like a mistake"So did the Patriots make a mistake as well ??
Dan Graziano (12:31 PM)
I don't know Brady's cap figures off the top of my head.
Huy (Montreal)
what exactly is your criteria on choising questions in a chat room?
Dan Graziano (12:31 PM)
Most interesting one on my screen after I refresh the list gets picked.
Sean (Virginia) [via mobile]
Too coward to post this question I'm sure but...who cares if blacks get interviewed for head coaching jobs. Last time I checked, teams weren't required to put one white running back into their search for a starter. It is what it is... Who cares!
Dan Graziano (12:33 PM)
I am no coward, sir, but you are a narrow-minded fool.
Huy (Montreal)
wow, you must really love the cowboys to spar with Kung Fu panda then.....aren't you more intrigued with what happens to Cole and Graham....nobody seems to be have given some thoughts in Cole becoming a 3-4 DE like justin smith
Dan Graziano (12:34 PM)
Fascinated by Cole and Graham. I think the Xs and Os of the Eagles will be among the most interesting stories of the offseason once they start minicamps, etc. I think they're both very talented, and I'm interested to know how Kelly plans to use those talents.
John (Miami)
If these are the most interesting questions, we are all in trouble.
Dan Graziano (12:35 PM)
It's March 5, John.
Jose [via mobile]
Do you think the boys will trade Spencer for draft pick? If yes. What can they get for him?
Dan Graziano (12:35 PM)
I think it's farfetched to believe a team will trade a draft pick for Spencer knowing they'll then have to pay him.
Uber (Frisco, Texas)
Kiper is the ESPN draft "guru" and a nice guy, but his track record isn't exactly that great as per identifying valuable OL. Agree on all counts that any close 1st round tie goes to the OL...but isn't a primary draft focus on OL more important than a 1st round edict? As we all know, value usually trumps needs. No agenda...other than I don't like positional edicts for the first pick.
Dan Graziano (12:38 PM)
I guess my point was that there will be a good value pick for them there at OL, and it's a long-neglected area of the team that's clearly hurting them on the field. You build your team through the draft and through the lines. I'd get a building-block OL piece with that pick and feel great about it.
Steve (VA Beach)
"I think it's farfetched to believe a team will trade a draft pick for Spencer knowing they'll then have to pay him"That makes no sense. Some team was going to pick him up in FA, so why not work out a deal for 5 years with him and then make the trade?
Dan Graziano (12:38 PM)
Well, because now you've spent the draft pick too. Cost went up.
Demetrius (Landover,Md) [via mobile]
The return of a healthy Chase Minnifield does what to the redskins secondary? How do u think it affects who they select with the 51st pick?
Dan Graziano (12:39 PM)
Well, it'd give them more options. But remember, as much as they liked him last year in camp, Minnifield hasn't shown he can play in the NFL. He'd come to camp this year as one of several question markets.
Dan Graziano (12:39 PM)
Kung Fu (flower)
Can the redskins cut Tanard Jackson while he is suspended? Why not do that if you aren't even sure he is going to play next season?
Dan Graziano (12:40 PM)
I do not think they can.
Andy (Pompano Beach, FL)
Agree or Disagree: Shanahan does not care about RG3's career? He just wants to win
Dan Graziano (12:40 PM)
I disagree.
Gary (New York City)
Dan, what is your opinion of Prince Amukamara as the Giants #2 CB and Jayron Hosley as the Giants nickel corner heading into 2013? Assuming the Giants find a number 1 CB or Webster players better that is....
Dan Graziano (12:41 PM)
I think Amukamara is fine, and if he's your No. 2 and Hosley is your nickel, that's a good setup. The question is whether Amukamara can be the No. 1 type guy Webster was for them two years ago. If he can't Webster's harder to replace now.
Mike Jenkins (Dallas) [via mobile]
Dallas obviously doesnt want me anymore. Will i be a Giant on opening day?
Dan Graziano (12:42 PM)
I think you're a very interesting guy who will have multiple teams interested. I don't know what the Giants think of you.
Rob (Scranton, PA)
First time chatter...!Is there any credence in my thought that maybe the redskins should delay the void from the RG3 trade by continuing to trade up for impact draft picks until a year when they can better afford to not have some good picks?
Dan Graziano (12:43 PM)
Your logic isn't unsound, but it's pretty tough to get into the first round from 51.
Huy (Montreal)
do you think Howie should trade all the 4-3 parts that are left (curry, cole) and get more draft picks since its a deep draft on defense?
Dan Graziano (12:44 PM)
They already have eight picks. Why not see what those guys can do in the new defense? They're very good players.
Tommy (NOLA)
fletcher cut, play or retire?
Dan Graziano (12:45 PM)
I think he plays.
Weech (SoCal)
With which funds exactly do you think Dallas will be addressing the safety? They certainly won't be going after the top guys in FA so why not just use a mid round pick to fill the need? They're very high on Matt Johnson.
Dan Graziano (12:46 PM)
They can be as high on him as they want to be, but there's no way an intelligent professional organization can be confident starting a guy they took at the end of the fourth round last year and who didn't play a single snap as a rookie. They will have other options in camp, I promise.
Mr. W (Dallas)
I know this idea was floated around alot earlier during the season, but maybe the Eagles ARE in fact moving Asomugha to safety and thats whats taking so long for the restructure. One saftey on roster, pursue Gohldson, draft Milliner at #4. sounds bout right Dan wouldn't you agree?
Dan Graziano (12:47 PM)
I don't see it. Tackling isn't Nnamdi's favorite pastime.
Matt (DC)
If the Redskins had their pick: Brent Grimes or Mike Jenkins?
Dan Graziano (12:48 PM)
I'd go with Grimes. Both have had injury problems, but I think Grimes has shown more in between his.
Austin (St Louis)
Brandon Albert for Anthony Spencer same cap hit both teams fill needs and it allows the chiefs to select Joeckel or Fischer who are obviously the only ones worth the #1 overall pick and gives dallas more choices on whether they go OL or DL in the first round
Dan Graziano (12:50 PM)
Well, it's interesting. I'll give you that.
Matt (Rhode Island Eagles)
I've heard a lot of talk that Kansas City might take Milliner as the #1 pick. If thats the case and the Eagles sit tight, do they take an offensive line guy like Joeckel or Fisher?
Dan Graziano (12:51 PM)
I'd have no problem with the Eagles going OL at No. 4. Get a building-block tackle, play him on the right side, move Herremans back to guard, maybe move the kid over to LT in a few years when Peters is gone... Not a bad play at all.
PooPooLighter (Leesburg VA)
Still waiting on getting that extra 15 minutes you jipt us out of a month ago.....
Dan Graziano (12:51 PM)
Keep waiting. You can use it this week to learn how to spell "gypped."
Matt (Philly)
With all this cap room do you think philly is going to make some big FA signing this off season
Dan Graziano (12:51 PM)
Yes. I do.
Matt W (Clifton Park, NY)
Answer my original POST DAN!!!!!!!!!! EVERY WEEK MAN... SAME THING!
Dan Graziano (12:52 PM)
rockin robin (independence, ks)
How happy are the cowboys with claiborne? If there was a redraft, would they take him again? Also, how do you compare claiborne with the best cornerback in this draft? THANKS!!! :)
Dan Graziano (12:53 PM)
I think they like Claiborne. I think they expected rookie struggles at that position, but I think he showed enough to justify him as a long-term solution there. I still don't agree with using two picks to get him, but that's what they decided to do. And I think he rates ahead of Milliner.
CJ (Albany) [via mobile]
What are the odds of Osi staying in NY?
Dan Graziano (12:54 PM)
I think pretty slim.
chris (Rochester)
Dan, if you had the choice of restructuring and keeping nnamndi, or trading him for a 4th round pick what would you do?
Dan Graziano (12:55 PM)
Honestly, I think I'd take the pick and move on. I think he can play, but I think Philadelphia is poisonous for him right now.
CJ (Albany) [via mobile]
Have you heard about any teams interested in a Bradshaw in free agency opens?
Dan Graziano (12:56 PM)
I have not. RBs have it tough as it is, and he's got health issues. Could have to wait a while.
Jason (Philly)
You said above that you expect the eagles to make a splash in FA. as an eagles fan, shouldnt i be skeptical based on the dream team disaster of 2011?
Dan Graziano (12:56 PM)
Dan Graziano (12:56 PM)
Andy (Pompano Beach, FL)
$6.5M per year for Cruz....too much?? Or is that more of a Nicks number?
Dan Graziano (12:57 PM)
I think that's low for Cruz.
Chris (Hoboken)
Do you have any confirmations that actual NFC East players follow and/or participate in the chat?
Dan Graziano (12:58 PM)
No, I don't think they do. But I know from personal experience last year that Evan Mathis follows the Twitter account and that Barry Cofield reads the All-Division Team.
matt (san antonio) [via mobile]
What sport do you watch while NFL on hiatus?
Dan Graziano (12:58 PM)
I'm a baseball and college basketball fan.
Billy Davis (Philly)
Will the first new pieces added to my defense this year be Sean Smith and Dashon Goldson or am I just dreaming?
Dan Graziano (12:59 PM)
I'd heard they weren't high on Goldson for some reason, but I don't recall where.
mike (pennsylvania)
dan says he picks the most interesting question.. yet he picks the osi question about staying in ny... un-be-leeeeeeeeevvvvvveeeeeee-able
Dan Graziano (12:59 PM)
You should have seen the other ones around it.
Dan Graziano (1:00 PM)
Thanks for the questions, folks. Catch you next week.
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text:
He's only months into a 19-year murder sentence, but Phil Spector appears to have abandoned any efforts to make friends with the hardened criminals with whom he may very well have to spend the rest of his natural life.
The legendary record producer, who invented the "Wall of Sound" and used to rub shoulders with the Beatles, now fears for his safety in the "snake pit" prison where he was sent after being convicted in May of killing a B-movie actress at his hilltop Los Angeles castle. In a letter to a friend made public yesterday, Spector, 69, spoke of his distress at being held in a medical facility at central California's Corcoran State Prison. Other inmates include mass murderer Charles Manson and Sirhan Sirhan, the man who shot Bobby Kennedy.
Spector said that lawyers were working to get him moved to "a better prison, with people more like myself in it, during the appeal process – instead of all these lowlife scumbags, gangsters and Manson types... They'd kill you here for a 39-cent bag of soup!"
Spector, who will not be eligible for parole until well into his 80s, said his only pleasures were regular visits from his 29-year-old wife Rachelle, who has been driving the 400 miles from their home in Alhambra twice a week. "She's a real trouper. It's like a dream come true having her by my side again," said the letter, which was released to the media by his publicist, Hal Lifson.
Rachelle brings him packaged food so that he doesn't have to go the dining hall with other inmates. "I know it's a chance to get out of my cell... but the less I see of the inmates, the better and safer I feel."
- More about:
- Gangster & Gangs
- Prison
- Punishment
- Robert F. Kennedy


text:
Surgery Intern- Need a good program
Surgery Intern- Need a good program
Hello Everyone-
I will be starting a very busy surgery internship in a few weeks and I need a efficient training program. I will be working around 80 hours per week so I am looking for something around 3x/week, 1 hour per session. I'm thinking a solid ABA, BAB program that hits all of the major muscle groups is the way to go.
I am 26. 6'3'' around 207lbs. Ex college football player, been lifting since high school. Fairly disciplined when it comes to diet and training. I have been counting calories and macro's since January with some good results. Currently eating around 2600 cals/day on average. My medium term goal is to lean out to single digit BF (around 12% right now) and keep my strength up.
If anyone had any suggestions, or personal experience with training on top of a rigorous schedule, I would love to hear it. Thanks.
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text:
With current trunk, just pulled and rebuilt less than an hour ago, if I reply to a message and then reply to another message, thus reusing the compose window from the previous reply, then the message header (addresses, subject) is read-only in the second reply.
Confirmed in Tb/24.0a1 (Application Build ID : 20130610030658) on Win-XP.
- if mail.compose.max_recycled_windows=0, no problem.
- Reply/Reply All only problem. No problem in new mail, forward.
- When problem occurred, "Shift+Reply" + "immediate window close"
+ "Reply/Replay All again" (open/close with different mode once)
is a simple recovery procedure.
Possibly due to bug 880595 - at least i don't see it with spellchecking diabled, and see it when it's on.
(In reply to Magnus Melin from comment #2)
> Possibly due to bug 880595 - at least i don't see it with spellchecking
> diabled, and see it when it's on.
Same time frame for the regression - making bug depedant.
I confirm turning spell check off so far has made the problem go away. It was pretty bad - sometimes the 'send' button was not clickable even.
*** Bug 887323 has been marked as a duplicate of this bug. ***
*** Bug 887458 has been marked as a duplicate of this bug. ***
Confirm the comment from Gene C - including the "Send" button being greyed out.
The comment #4 at https://bugzilla.mozilla.org/show_bug.cgi?id=880595 will hopefully mean that this associated bug will be closed at the same time when and if the patch referred to is confirmed to fix this problem?
*** Bug 890603 has been marked as a duplicate of this bug. ***
COnfirming - I'm seeing this pretty much continually, (Reported in duplicate Bug#890603) and Send is always disabled which makes it impossible to reply.
For anyone caught by it ... the work around is
Reply - get unusable window, but you won't notice till you look for Send.
Copy the message you just typed
Go back to message -
hit Reply again - get usable window
Past message into it.
Hit Send
Close orginal window without saving Draft.
You have to do it in this order or mostly it just reuses the screwed up window again.
If someone wants help tracking it let me know - otherwise I'm going to have to do a reinstall to see if that makes it go away.
Reinstallation won't help. Go into the Config Editor (that's in the Options or Preferences menu item in the [≡] application button on the right-hand side of the main toolbar, then the Advanced > General tab, click Config Editor there).
Per comment #1, enter or copy-paste mail.compose.max_recycled_windows into the search bar and double-click on the entry that remains to change it to 0.
I'm seeing the Send problem even with max_recycled_windows at 0. The way I work around it is to save and close the draft, then go to my Drafts mailbox, open the message again, and send it.
max_recycled_windows at 0 resolves it so far for me.
Is it known yet whether attachment 773324 [details] [diff] [review] of bug 880595 resolves this?
Created attachment 778041 [details] [diff] [review]
Proposed patch
Since I couldn't work out how bug 887010 was going to help us, I took a different approach. Note: I tested the code in SeaMonkey and then ported it without testing on Thunderbird. Thus this patch also fixes bug 889882.
Tested on a local build:Mozilla/5.0 (Windows NT 6.1; WOW64; rv:25.0) Gecko/20100101 Thunderbird/25.0a1 ID:20130718210143 CSet: d7237cd27263
Built from http://hg.mozilla.org/mozilla-central/rev/0d0263a58f06
After importing this patch, it seemed to take care of the message header greyed out problem, but the inline spellcheck problem is still there when
(but maybe this patch wasn't intended to address that issue)
(In reply to Joe Sabash from comment #15)
> the inline spellcheck problem is still there when
> mail.compose.max_recycled_windows=1
> (but maybe this patch wasn't intended to address that issue)
That's attachment 773324 [details] [diff] [review] in bug 880595.
Created attachment 779118 [details] [diff] [review]
Alternative approaches
This demonstrates two alternative uses of the spellCheckPending property although I haven't actually tested this version yet.
Comment on attachment 779118 [details] [diff] [review]
Alternative approaches
Review of attachment 779118 [details] [diff] [review]:
I think I prefer this version best. It seems more deterministic.
::: mail/components/compose/content/MsgComposeCommands.js
@@ +3145,5 @@
> if (gSpellChecker.enabled)
> {
> + if (gSpellChecker.mInlineSpellChecker.spellCheckPending)
> + {
> + setTimeout(addRecipientsToIgnoreList, 100, aAdressesToAdd);
I think I'd prefer this to use the observer method as you have done further down.
*** Bug 897644 has been marked as a duplicate of this bug. ***
Created attachment 781120 [details] [diff] [review]
Alternative patch
Comment on attachment 781120 [details] [diff] [review]
Alternative patch
Review of attachment 781120 [details] [diff] [review]:
Looks good. r+a=me for the CLOSED TREE and for aurora.
Pushed comm-central changeset 55edd6e9957e.
Pushed comm-aurora changeset d4eb28c60ab5, but I typo'd the bug#. Oops!
*** Bug 896191 has been marked as a duplicate of this bug. ***
*** Bug 889882 has been marked as a duplicate of this bug. ***


text:
Intervention Review
You have free access to this content
Beclometasone for chronic obstructive pulmonary disease
Editorial Group: Cochrane Airways Group
Published Online: 9 OCT 2013
Assessed as up-to-date: 6 FEB 2013
DOI: 10.1002/14651858.CD009769.pub2
Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Database Title
Additional Information
How to Cite
De Coster DA, Jones M, Thakrar N. Beclometasone for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD009769. DOI: 10.1002/14651858.CD009769.pub2.
Publication History
- Publication Status: New
- Published Online: 9 OCT 2013


text: OverviewBack to top Starwest Botanicals - Revitalize Essential Oil (1/3 oz.) - 0.33 oz. Item# :67338UPC# :767963003751 Brand:Starwest Botanicals Size/Form:0.33 oz. Starwest Botanicals - Revitalize Essential Oil (1/3 oz.) - 0.33 oz. Starwest Botanicals Revitalize Essential Oil is an unusual blend that enhances both physical energy and mental power. A great motivator to exhilarate and overcome lethargy and fatigue. Refreshes and sharpens the mind. Essential oil blends from Starwest are crafted from therapeutic-grade oils distilled from plants, shrubs, flowers, trees, roots, bushes and seed. When certain essential oils are combined in a way that amplifies their power, the result is a synergistic Aromatherapy Essential Oil therapeutic blend. Our aromatherapy essential oil blends stimulate and invigorate the senses and can be used for improving one's emotional and physical well-being. Starwest's eight synergistic Aromatherapy Essential Oil Blends are specially formulated for specific purposes, which are reflected in their names: BodyCalm, BreatheFree, Enchantment, NewSelf, Radiance, Revitalize, Serenity, and WarmDown. Each blend can be used with an aromatherapy diffuser, misting their potent aroma through the air. Enhance your physical and psychological well-being by adding our crafted essential oil blends to your aromatherapy treatment.


text:
These are short- term international learning programs that are directly led by Elms College faculty. Typically, these programs are under one month and students pay a program fee. Programs offered vary from year to year.
Elms College faculty lead and travel internationally with a small group of students. Any course(s) are also taught by Elms faculty. Credits and grades earned are posted on your transcript.
Involves volunteer work. This may include work with children and families, home visits, healthcare clinic, and/or light manual labor. Students can earn thirty hours of community service.
We are a private Catholic coeducational liberal arts college founded in 1928 by the Sisters of St. Joseph of Springfield, Massachusetts. Elms College is located in Chicopee, Massachusetts, and grants associate's, bachelor's, master's, and doctoral degrees.


text:
Sales Ended
Macedonia Baptist Church - New Members Class
Actions and Detail Panel
Macedonia Baptist Church - New Members Class
Sun, December 25, 2016, 9:30 AM – 10:30 AM CST
Sales Ended
Event description
Macedonia's New Members Class will meet as needed 1st & 4th Sundays in 2016 from 9:30am - 10:30am.
However, you must register for the class so that we can be excellently prepared for you!!!
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- An overview of the entire membership process
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- The importance of spiritual growth
- Growth Group assignment
- Spiritual Gifts Assessment
Welcome to Macedonia!
Share with friends


text:
UCLA football: Safety Tony Dye looks to shed red jersey
The neck roll stood four inches (or more) above the collar of Tony Dye's red, non-contact jersey. A not-so-subtle reminder of a neck injury that has sidelined the UCLA safety the past two games.
"It's frustrating," Dye said after his limited practice Wednesday. "I can't turn my head....When I get into a stance, I'm just looking at the ground."
Because of the school's new policy on injuries, Dye wasn't allowed to comment on his injury that two weeks ago was listed as "general soreness." But he did say that it's been frustrating watching his senior season slip by.
"If it were up to me, I would be on the field right now... with a different color jersey on," Dye said, pulling at the red shirt. "I'm working as hard as I can to get back."
What could be even more frustrating for him is if he can't play Saturday against pass-happy Washington State. The 3-1 Cougars are averaging 379 yards passing and have scored 16 touchdown through the air.
"They haven't done this amount of passing in years and they are very efficient in their passing game," Dye said.
Dye and starting cornerback Sheldon Price both missed the Stanford game as did nickel back/safety Alex Mascarenas and strong safety Dalton Hilliard. Dye and Hilliard are listed as probable for Saturday's game, while Price and Mascarenas are questionable.
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text:
Chris, your method sounds very logical. Of course when DH and I got
married, I had to learn about binary code and hex to be able to talk to my
then Cobol programmer husband! LOL!!! He has always been very, very
logical. I swore I was married to Mr. Spock from Star Trek for the first
few years we were married!!! LOL!!! Perhaps it's a guy thing?
Bonnie (SW OH - zone 5)
-----Original Message-----
From: firstname.lastname@example.com [mailto:firstname.lastname@example.com] On Behalf
Of Cathy Carpenter
Sent: Monday, April 10, 2006 7:11 PM
To: firstname.lastname@example.com
Subject: Re: [CHAT] Plant list up
More than I want to know! : > )
Cathy, west central IL, z5b
On Apr 8, 2006, at 4:44 PM, Christopher P. Lindsey wrote:
>> OK, Chris, I gotta ask:
>> How did you come up with your codes?
> :)
> The first part of the code is actually the genus -- each genus gets
> its own number, and they're created sequentially. For example,
> Knautia 'Mars Midget' is 122.
> Since I wanted to keep the code short for the bar codes that go on the
> pots, I then convert it to a hexadecimal value (basically, a base 16
> system instead of base 10). So 122 becomes 07A. It makes more of a
> difference when you get to larger numbers; 1000 is 3E8, so it takes
> one character less.
> The second part is base 10 and is an identifier for the species.
> The first species in a genus is 0001, the second is 0002, etc.
> When you receive your plants there will be a third number, and that
> will be the plant number in base 16 again.
> So 07A-0001-0001 would be the first plant, but 07A-0001-0010 would be
> the 16th plant.
> Each one has a unique bar code and id number (I wrote a program to
> print out the labels). I can then track specific plants if need be:
> if one has a problem, I can document it and record what I've done with
> it.
> I can also use it to identify seedlings of interest for plant breeding
> and to log fertilizer applications and the like.
> The biggest advantage is using it to meet state requirements. I can
> also track each plant back to its original source which is something
> that we're required to do by law. If a supplier comes to me and says
> that their plants were infected with something, I can immediately
> identify which of my plants came from them and identify any customers
> that might be affected as well.
> Someone on the list said I overthink things too much. I dunno. :)
> Chris
> ---------------------------------------------------------------------
> To sign-off this list, send email to firstname.lastname@example.com with the
> message text UNSUBSCRIBE GARDENCHAT
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text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Larry Isaacs <Larry.Isa...@sas.com>
|Prep for Beta 6
|Mon, 02 Oct 2000 12:55:30 GMT
Hi Sam, I was going to commit Rob S.'s update this afternoon as well as a couple of documentation updates of my own. Were you planning the beta 6 build for tonight, or has it already occurred? Thanks. Larry P.S. The binaries on the IBM ftp site have had problems this last week. Watchdog isn't building (i.e. the watchdog files have been very short) and jakarta-tomcat.zip contains a recent version of Ant instead of Version 1.1. __________ Larry Isaacs email@example.com SAS Institute Inc.
|View raw message


text:
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text:
Ezra cannot proceed in his story without inserting his thankful acknowledgement of the goodness of God to him and his people in this matter. As soon as he has concluded the king's commission, instead of subjoining, God save the king (though that would have been proper enough), he adds, Blessed be the Lord; for we must in every thing give thanks, and, whatever occurrences please us, we must own God's hand in them, and praise his name. Two things Ezra blessed God for:—1. For his commission. We suppose he kissed the king's hand for it, but that was not all: Blessed be God (says he) that put such a thing as this into the king's heart. God can put things into men's hearts which would not arise there of themselves, and into their heads too, both by his providence and by his grace, in things pertaining both to life and godliness. If any good appear to be in our own hearts, or in the hearts of others, we must own it was God that put it there, and bless him for it; for it is he that worketh in us both to will and to do that which is good. When princes and magistrates act for the suppression of vice, and the encouragement of religion, we must thank God that put it into their hearts to do so, as much as if they had granted us some particular favour. When God's house was built Ezra rejoiced in what was done to beautify it. We read not of any orders given to paint or gild it, or to garnish it with precious stones, but to be sure that the ordinances of God were administered there constantly, and carefully, and exactly according to the institution; and that was indeed the beautifying of the temple. 2. For the encouragement he had to act in pursuance of his commission (Ezra 7:28): He has extended mercy to me. The king, in the honour he did him, we may suppose, had an eye to his merit, and preferred him because he looked upon him to be a very sensible ingenious man; but he himself ascribes his preferment purely to God's mercy. It was this that recommended him to the favour of his prince. Ezra himself was a man of courage, yet he attributed his encouragement not to his own heart, but to God's hand: "I was strengthened to undertake the services, as the hand of the Lord my God was upon me to direct and support me." If God gives us his hand, we are bold and cheerful; if he withdraws it, we are weak as water. Whatever service we are enabled to do for God and our generation, God must have all the glory of it. Strength for it is derived from him, and therefore the praise of it must be given to him.
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text:
Joomla Customization
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- Forbes
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text:
Top Definition
Small force of partiers who specialized in bonewarfare and party throwing nationwide. Headquartered in a secure facility in the Arizona desert, Ill Squad has established outposts in Oregon, Texas, Florida, Chicago, Idaho, and even the Middle East. Their forces are currently at war with So-Cal and Nor-Cal simultaneously due to the fact that both cals hella suck.
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by ILL joint chief September 03, 2006
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text:
Scroll down
Michelin-starred Wing Lei is Wynn's signature Chinese restaurant, serving classic Cantonese cuisine and exquisitely hand-crafted dim sum. Dine under the sparkling eyes of Wing Lei's iconic crystal flying dragon, or in one of five private dining rooms equipped with flat screen TVs and private washrooms.
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text:
In this renewal application I propose experiments to study how a neuroinvasive alpha herpesvirus (pseudorabies virus, PRV) infection drives axonal targeting of virions and viral proteins to promote anterograde spread of infection in the nervous system. These experiments take advantage of our technology advances in imaging, neuronal culturing systems, mass spectrometry, and deep sequencing, as well as new findings from the last funding period. In particular, we will focus on imaging US9, a critical protein for sorting virions into axons (aim 1). Using mass spectrometry and new enrichment techniques, we will determine the proteome of enriched vesicles containing GFP-US9 and gE-GFP and initiate studies to identify US9-specific protein complexes (aim 2). Finally, we will extend our work to test new hypotheses concerning the axonal damage response, the role of local axonal translation on viral axonal transport, and, using deep sequencing technology (Ilumina platform), how PRV infection affects not only axonal targeting of viral proteins, but also of host and viral mRNAs (aim 3).
The direction taken by the virus in a neuron after primary infection or reactivation from latency, as well as the extent of spread in a neuronal circuit can be the difference between a minor peripheral infection and lethal brain infection. My work will provide basic knowledge toward understanding how to block neuronal spread and its resulting damage. As viral tracing of neural circuitry has become an essential tool in the neuroscience community, our new discoveries will be immediately applicable for many ongoing fundamental research projects in neuroscience in a variety of animals with the promise to reveal detailed functional insights into neural circuit organization that have not been possible to achieve in the past.
|Bosse, Jens B; Virding, Stina; Thiberge, Stephan Y et al. (2014) Nuclear herpesvirus capsid motility is not dependent on F-actin. MBio 5:e01909-14
|Oyibo, Hassana K; Znamenskiy, Petr; Oviedo, Hysell V et al. (2014) Long-term Cre-mediated retrograde tagging of neurons using a novel recombinant pseudorabies virus. Front Neuroanat 8:86
|Sun, Xiaonan R; Badura, Aleksandra; Pacheco, Diego A et al. (2013) Fast GCaMPs for improved tracking of neuronal activity. Nat Commun 4:2170
|Granstedt, Andrea E; Bosse, Jens B; Thiberge, Stephan Y et al. (2013) In vivo imaging of alphaherpesvirus infection reveals synchronized activity dependent on axonal sorting of viral proteins. Proc Natl Acad Sci U S A 110:E3516-25
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