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|Property type
|Minimum Stay
|14 - 90 nights
Location, Location, Location St Armands Circle. This Great Condominium Complex with heated pool & hot tub is located only 300 yards from beautiful Lido Beach and a few steps from world
famous St. Armands Circle. The location dosent get any better than this. Just 1 mile to Sarasota Downtown with all it's restaurants, culture, Marina Jacks and the Bayfront Park.
First floor Unit, 2 bedrooms, 2 bathrooms. Master bedroom with a king bed, 32" LCD TV and
its own bathroom. Second bedroom with Queen bed and its own bathroom. 40" LCD TV
in living room and free wireless internet . IN Jan 2013 a completely remodeled Kitchen with new cabinets, granite counter, double sink and New Stainless Steel appliances. Lanai facing west.
St. Armand's Circle in Sarasota, Florida. Award-winning cuisine by master chefs. Enjoy casual fare from the many specialty food shops or dine leisurely on superb cuisine from around the world. And ...
fulfill your shopping passions.... You don't have to travel far to find the world's
treasures. Not to mention walking to the beautiful white powder sand of Lido beach just 300 yards from you condo. Enjoy the sunsets and dont forget to bring your wine.
To view this unit on line contact me and I can send you a link
Pets Not Allowed
Children Welcome
I moved to Sarasota in 2012 and now spend half my time in Sarasota and the other in NY where we have a summer home in the Hamptons
Jeffrey Heath purchased this condo in 2013
I bought this condo in December of 2012 because of its location. You cant get better than this located one block from St Armands Circle with the world class shopping, restuarnts and 300 yards to the beautiful Lido Beach with its white powdery sand. You have the culture of Sarasota 1 mile away and Long Boat key next door.
I remodeled This condo with a all new Kitchen, updated bathrooms and new furniture, TVs and linens as well new utensils.
What I love about this location is the close proximity to the fabulous restaurants and the white sand beach just steps away. there are two nature parks on Lido that you can walk or take a kayak out or even go on a sunset tour through the mango groves. On Saturday mornings a quick ride over the Ringling bridge to Main St. in Sarasota for the Framers Market.
What a wonderful home for a few weeks. Perfect for myself,husband and 10 year old son. Condo was clean and well equipped. It is a 10 minute walk to Lido Beach. Condo had a nice basket to load beach supplies up and walk to beach. Lot's of good restaurants to choose from just around the corner in St. Armand's Circle. My son's favorite was "Kilwins ice cream" only a few minutes away. Nice shops and I recommend "The Met" for spa service. The owner Jeff, always responded quickly with any questions I might have, thanks Jeff! I highly recommend this condo and would go back again in a heart beat. :)
The condo was clean, well equipped, and in a convenient location. It was just a short walk to the beach and St. Armand's Circle. The pool was warm and very clean. The owner was easy to contact and even stopped by to see if we were satisfied with the unit. I would definitely recommend this condo.
I stayed at this condo for two weeks last year, in May and was pleasantly thrilled I did. The condo is very clean, well kept and tastefully decorated. Everything you need is in the unit. The owner ( Jeff) was wonderful to communicate with and even stopped by to see if all expectations were met...they absolutely were. I have stayed at other units in this community ( was very disappointed in management company and care of that unit) with disappointing results. This rental property far exceeded my expectations. I look forward to staying here again in the future. The location is unparalleled to others in the area.... all your needs are foot steps away. The ground in the condo community are quite nice and well kept as well. Thank you !
The owner of this well-kept and organized condo is a delight and very responsive. I was looking for a place to telecommute from while my children were in a two week sailing camp nearby. I grew up in the area and typically rent on Siesta, but needed the location of St. Armand's this year. What a joy it was to be able to go to so many good restaurants and get to the beach so quickly for a morning and evening walk on the beach. We are renting again next year1
Location, location, location!
The perfect condo for the perfect vacation. One block to the most beautiful beach you'll ever find and less than a block to the incredible Saint Armand Circle with lots of restaurants, stores and people watching. The beach is incredible! I saw over a dozen Manitee, half a dozen dolphin and numerous stingrays. Even beach chairs and umbrella. And don't forget your private parking spot. You can't go wrong.
The price is also great for a two bedroom/2 bath condo.
Jacuzzi and Pool also top of the amenities at this incredible place.
I stayed for 3 weeks, wish I had booked longer!
P. Pisani NJ
We stayed in this lovely apartment for the whole of October. Jeff's description was certainly true: located almost on the circle and a short walk to the beach. The layout of the apartment was spacious and comfortable and there was no shortage of kitchen utensils, crockery, glasses, cutlery etc. The pool area and gardens were well maintained and cleaned. No noisy neighbours even though we were next door to Tommy Bahamas Bar which proved to be our favourite drink and dining eatery. The weather was glorious, only 2 days bad weather which wasn't bad out of the 29 days we were there. As we didn't have a car we relied on the buses to go further afield. They were efficient and easy to use and much cheaper than getting cabs. The John Ringling Museum and the Mote Aquarium are worth a visit, very informative. Apart from Tommy Bahamas, The Venezia was another favourite eating place. Mattisons Bar and Grill in Down Town Sarasota was a fun place with excellent live music. There are great shops in St Armands that stay open late at night so after eating we would shop, what more can a girl ask for...! We would certainly recommend this condo to friends and family. It is safe and at no time did we feel uncomfortable about the area. Whether young or old it has just about all you would need for an enjoyable holiday. Thank you Jeff for sorting out any problems we had so promptly. Lesley and Joy
Top Thing to do in City:
* Eat you heart out.
* Go to Lido beach.
* Go kayaking thru the mangroves.
* Walking over the Ringling bridge.
* shop at St Armands Circle.
Top Thing to do in Budget:.....
Top Thing to do in Family:.....
Fitness Center
Jet Skiing
Live Theater
Health/Beauty Spa
Sight Seeing
|Rate Period
|Weekend Night
|Monthly *
Jan 1 2017 - Mar 31 2017
90 night minimum stay
May 1 2017 - Jun 30 2017
14 night minimum stay
|$99 + Tax
|Refundable damage deposit
|Tax Rate
MINIMUM 2 week rental
12% Florida State Occupency tax
Cleaning fee of $99
May 1 - Oct 31 $1500 for 2 weeks, $2850 for Monthly
June 28th - July 11th for 2 weeks $1595
Nov & December $1675 for 2 weeks, $3200 for Monthly
Jan 1 to April 30th $3450 for Monthly
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.


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Guest reviews
Overall rating
8.5 Excellent
Based on 45 reviews
Hotel type
Solo Hotel
recommend this hotel for solo travelers.
data provided by TrustYou
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A great choice for a stay in Torreon, Hotel Fresno Galerías is just 2.1 mi (3.3 km) from the airport. For a bit of exercise, you can visit the fitness center or go for a swim in the outdoor pool. Other highlights include a garden, and rooms offer flat-screen TVs and room service.

subset: commoncrawl


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Pad holder has an upper and lower frame to hold your 24" x 24" housebreaking pads in place. Frame only, no bottom tray.
Especially useful when your playful puppies like to teeth and drag the pad all around the room.
Quick snap design makes changing pads easy.
Frame measures:
22-1/2"L x 22-1/2"W x 1-1/2"H
LAST CALL - No More When Gone
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I know, I know. Any movie starring a central character from That '70s Show or Punk'd has a strike against it, right?
Wrong. Ashton Kutcher is not reprising his role as a simpleton in The Butterfly Effect: Director's Cut (2004). To the contrary, Kutcher here is multifaceted and mostly serious as "Evan Treborn". (In addition, he serves as executive producer.)
An intriguing mental exercise is to analyze how one's life might be different if certain events didn't happen (or happened differently). For example, what would your life be like now if you didn't go to a particular college? Would you have met your spouse; secured your current job? Sliding Doors with Gwenyth Paltrow tried to explore this fruitful concept in the 1998, but failed to deliver.
The Butterfly Effect does not fail. It delivers a fascinating story that it constantly mutates by revisiting and tweaking pivotal circumstances, and then displaying the repercussions.
Theologically speaking, The Butterfly Effect clearly would fall heavily on the side of self-determination as opposed to divine will; free will over predestination. Psychologically or sociologically speaking, it's all about nurture versus nature. Outside events essentially control in this world.
I emphasize that I saw the director's cut version on DVD, because according to the filmmakers' commentary, the ending for the director's cut differed from the theatrical version, which they briefly described. Go with the director's cut–it's extremely intense, disturbing and thought-provoking.
The Butterfly Effect receives a "B+".Powered by Sidelines


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When it comes to pastries, we Latinos definitely know what we're doing. From elaborate Spanish Milhojas to the buttery sweet comfort of Cuban pastelitos, there is something to satisfy every craving. The only question left is what to drink along with it? Here are 10 of the best Latin pastry and coffee pairings to enjoy on your next coffee break.
Pan de MallorcaView all slides
MilhojasView all slides
Pastelito de GuayabaView all slides
ChurrosView all slides
Pan DulceView all slides
QuesitoView all slides
Pastel de NataView all slides
AlfajoresView all slides
PandebonoView all slides
RosquitasView all slides
Next Slideshow: Juicing 101: 5 Tips for Salma Hayek's Favorite Healthy Trick
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Pan de Mallorca + Black Coffee
These soft and fluffy rolls—also known as ensaïmadas—are traditionally served dusted with a generous shower of powdered sugar. Popular in Puerto Rico, they originally came from the Spanish island of Majorca (hence the name). Enjoy it toasted with plenty of good butter, or tuck in a few slices of salty ham and cheese for the ultimate breakfast. Beautifully sweet on their own, these are best served with a cup of strong and freshly brewed black coffee.
Milhojas + Macchiato
Many thin, flaky layers of pastry are filled with arequipe—a sweet cream made of condensed milk, sugar, and vanilla. It's an elegant pastry that is best served as dessert after a fine meal. This rich confection will need something strong to cut the sweetness, so enjoy it with a classic macchiato—a shot of strong espresso topped with just the smallest dollop of frothed milk.
Pastelito de Guayaba + Caffè Misto
Craving something a little comforting? Look no further than these Cuban sweets! Flaky, buttery puff pastry is filled with sweet and fragrant guava paste, then baked until golden. It's the perfect afternoon snack to enjoy with a Caffè Misto-which is what Italians call a café con leche. Made with equal parts strong coffee and sweet steamed milk, it's just the thing to sit, sip, and savor.
Churros + Caffe Mocha
Churros and hot chocolate are a classic combination, but why not kick it up a notch and pair them with a mocha, instead? Two or three of these crisp fried dough sticks dusted with cinnamon sugar are the perfect match for a rich mug of chocolatey coffee. Don't forget the whipped cream on top!
Pan Dulce + Caramel Flan Latte
In Mexico, pan dulce is a breakfast staple. These sweet bread rolls are prepared in a variety of different shapes and colors that are almost as fun to look at as they are to enjoy. Whether you choose an iconic concha, with it's shell-like sugar topping, or a corn-shaped pan de elote, enjoy them alongside a Starbucks Caramel Flan Latte. The combination of freshly brewed espresso topped with caramel-infused whipped cream and a caramel drizzle is the perfect pairing for the lightly sweet Mexican treats.
Quesito + Latte
Reminiscent of a classic cheese Danish, Puerto Rican quesitos are made from a buttery puff pastry that is filled with sweet cream cheese filling and topped with a sweet and sticky sugar glaze. Best served fresh from the oven, try them alongside another coffeehouse classic: the latte—a shot of bold espresso topped with sweet steamed milk.
Pastel de Nata + Iced Coffee
Small and round with a flaky pastry on the outside, and a creamy vanilla-scented custard on the inside, these tiny Portuguese tarts are just the thing to enjoy on warmer days when you're craving a taste of something sweet that won't weigh you down. Paired with a refreshing iced coffee, they're a perfect treat for those hotter days.
Alfajores + Espresso con Panna
Enjoyed throughout Latin America, Argentina and Uruguay usually get the credit for these decadent cookie sandwiches. Two sweet crumbly cookies joined together with a filling of dulce de leche or jam, then dipped in chocolate, powdered sugar or coconut. They're rich and luscious, so why not continue the trend? Enjoy these with an equally luxurious Espresso con Panna—otherwise known as an espresso with sweet whipped cream.
Pandebono + Cappuccino
Chewy and the perfect mix of sweet and salty, these puffy Colombian cheese breads are totally addictive (you've been warned!). A perfect breakfast or late-afternoon snack, these are light enough to pair with something rich, like a mug of foam-topped cappuccino.
Rosquitas + Americano
With just a hint of licorice-like anise flavor, these sweet and crunchy bread rings are made for dipping. Popular in Peru and Ecuador, where they are commonly sold on the street and small cafes, they're ideal alongside a cup of your favorite freshly brewed coffee. Instead of the usual drip, try them with an Americano—it's an espresso that's been stretched with a little extra water, giving it a richer, more nuanced flavor.
Sponsored by Starbucks


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Town Square
Huff student a whiz at math
Original post made on Nov 5, 2012
Read the full story here Web Link posted Monday, November 5, 2012, 2:54 PM
Comments (3)
a resident of Old Mountain View
on Nov 5, 2012 at 5:21 pm
Math is the key to understanding the observable universe.
Somebody should get this student a introductory physics book so he can get a head start in high school. In my experience, great math students also excel in physics.
a resident of Slater
on Nov 6, 2012 at 2:35 pm
gcoladon is a registered user.
Congratulations Nitin! Awesome performance. :)
a resident of Martens-Carmelita
on Apr 30, 2013 at 12:59 pm
Hello, this is me, Nitin.
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Engagement Rings: Myths and Options
By Chandrama Anderson | 1 comment | 1,685 views
Opening alert: Go Fish Poke Bar in Redwood City
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|"Uma Maheswara Rao G (JIRA)" <j...@apache.org>
|[jira] [Commented] (HDFS-3605) Block mistakenly marked corrupt during edit log catchup phase of failover
|Sun, 15 Jul 2012 05:53:34 GMT
[ https://issues.apache.org/jira/browse/HDFS-3605?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=13414580#comment-13414580 ] Uma Maheswara Rao G commented on HDFS-3605: ------------------------------------------- Thanks a lot, Todd for the patch. I have taken a quick look on the patch. Yes, this approach should work as well. Blocks will get processed for all the ops, so, the matching to current genStamp will get processed in current iteration and future ones will get postponed again. A few comments on patch: Did not check for any javadoc issues as you mentioned already, i.e, will work on javadocs. {quote} + out.writeBytes("/data"); + + // TODO: why do we need an hflush for this test case to fail? {quote} I remember, this is just added to ensure tthat the current packet will be en-queued and block will get allocated. Other wise less than 64K content may not be flushed at that time. {quote} DFSTestUtil.appendFile(fs, fileToAppend, "data"); {quote} Having the multiple append calls can give the regression for the case where we have many genstamp and they got processed in order and future ones will get postponed. {quote} // Wait till DN reports blocks + cluster.triggerBlockReports(); {quote} comment need to update? {quote} shouldPostponeInvalidBlocks {quote} do we need to change the variable name? Since blocks are not declared as invalid yet. Will take a look deeply on the patch tomorrow again. ( not able to concentrate much, as I am traveling today) > Block mistakenly marked corrupt during edit log catchup phase of failover > ------------------------------------------------------------------------- > > Key: HDFS-3605 > URL: https://issues.apache.org/jira/browse/HDFS-3605 > Project: Hadoop HDFS > Issue Type: Bug > Components: ha, name-node > Affects Versions: 2.0.0-alpha, 2.0.1-alpha > Reporter: Brahma Reddy Battula > Assignee: Todd Lipcon > Attachments: HDFS-3605.patch, TestAppendBlockMiss.java, hdfs-3605.txt > > > Open file for append > Write data and sync. > After next log roll and editlog tailing in standbyNN close the append stream. > Call append multiple times on the same file, before next editlog roll. > Now abruptly kill the current active namenode. > Here block is missed.. > this may be because of All latest blocks were queued in StandBy Namenode. > During failover, first OP_CLOSE was processing the pending queue and adding the block to corrupted block. -- This message is automatically generated by JIRA. If you think it was sent incorrectly, please contact your JIRA administrators: https://issues.apache.org/jira/secure/ContactAdministrators!default.jspa For more information on JIRA, see: http://www.atlassian.com/software/jira
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Engineered for women, the Louis Garneau Womens Cristal Road Shoe is a value-conscious yet high-performance shoe for new roadies or veteran enthusiasts. Product no longer available for purchase.
Thank you for visiting Louis Garneau Womens Cristal Road Shoe on oakleysbikes.co.uk
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Sign up today for our email list and receive all the best specials, coupon offers, and new product announcements. If you upload a Pet Profile favorite photo of your pets, that will be included in the email as well to remind you who really loves you!
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I probably have 12 of these. They are without question, one of the easiest, simpliest, no frill, everyday all in one harness and does not add any pull or risk to injury to the throat or neck. Don't hesitate to try it.
Love this harness. It's adorable and keeps my Lily safe.
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Comment Re:what about not giving a printer an public IP (Score 1) 83
Feed the printer from a print server and put the printer on its own VLAN.
Feed the printer from a print server and put the printer on its own VLAN.
I'm not suggesting that anyone start lying. If security is important, just take the extra steps and get hardware that protects the keys and contracts to divide the access.
The right answer is Sorry the keys are stored in tamper resistant hardware modules and can't be extracted or duplicated without the cooperation of 3 of 5 individuals located in different countries.
I was in the Kona, HI airport yesterday and someone had a mosquito net over his head. It wasn't to protect him from mosquitoes, it was to protect the local mosquitoes from him. I believe he had just been released from a hospital after arriving from South America.
I've seen detectors mounted on trees in a nearby wooded state park. They appear to be shoulder high beam break type detectors with transmitters. I suspect it's to catch people after the park is closed but who knows.
Sorry for the poor wording. Secondary protectors are placed near the equipment to be protected to suppress over voltages and only if there is a primary protector where the wiring enters the building. The secondary protector might be exposed to a power cross that gets past the primary. As such, the current must be limited to what the inside wiring can safely manage. This is usually done with some type of fuse or current limiting device. This limits current to ground for voltages that exceed the clamping voltage of the surge protection. Typically, this will open the input signal leads to stop the current to ground and take the device out of service. There may be some type of indicator to show a fault is present. Once open, if the power cross is still present, the input wiring might still be at a dangerous potential. Compliance with wiring insulation and clearance standards hopefully prevents contact. The fusing should keep the inside wire from burning and isolate the equipment.
You can put a PoE power injector and fiber adapter in a NEMA box next to the WiFi. That would require AC power at or near the antenna (more money) but it keeps the surge out of the data side.
BTW, We had a lightning hit that split a big tree maybe 30m from the building. I just about jumped out of my shoes. The VoIP phones rebooted but the switch supplying PoE took the hit without a reboot. I'm glad there was secondary protection on the POTS gateway.
You can install secondary protectors near the equipment. These usually have a fused ground connection. This is to stop currents that might exceed the inside wiring limits if the fault passes the primary protector. Otherwise the inside wiring might start a fire. It's still best to go with fiber for external devices like a roof mounted WiFi adapter.
If you can't turn it off, user your own WiFi router and enclose theirs in a large metal box so it doesn't use up spectrum. Verify there is enough shielded vents so it doesn't run hot.
It would seem like a CAC card and an email client with S/MIME would be and easy road to doing the encryption. Unless the message is such that the possible existence of a key pair escrow somewhere makes use of a CAC card dangerous to ones career.
Some things will never change. We won't renumber street addresses or move survey markers. Others things could change over night. If there was an additional 1% federal tax on gasoline sold by the gallon, people would be tripping over each other setting pumps to Liters. It's all about finding a reason for the average person to care.
Maybe it's time for the operators to be licensed with mandatory education (it is a transmitter after all). The device shouldn't operate unless the operator enters their license number and the court document number authorizing the interception. A third party should audit the operational log.
I had a high end system with lots of keypads and dimmer switches. I removed it after finding out that the dimmer switches didn't get along with any LED bulbs. The only feature I really was happy with was "all lights on" triggered by the fire alarm. The furnace blower rotor locked at 2AM on a cold New Years day. It was nice to have all the lights on when I started searching for the source of the smoke.
Mail servers can be configured to not offer login unless starttls is used. That should prevent a plain text connection. That still leaves open the issue of mitm with certificates that the client shouldn't trust. Are there any email clients that lock starttls to a specific certificate or warn that the certificate suddenly changed?
I consider a new device or technology to have been culturally accepted when it has been used to commit a murder. -- M. Gallaher


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- 1[countable, uncountable] a false idea or belief, especially about somebody or about a situation She's under the illusion that (= believes wrongly that) she'll get the job. The new president has no illusions about the difficulties facing her country (= she knows that the country has serious problems). I have no illusions about her feelings for me (= I know the truth is that she does not love me). He could no longer distinguish between illusion and reality. I don't want to have my illusions shattered!
- 2[countable] something that seems to exist but in fact does not, or seems to be something that it is not Mirrors in a room often give an illusion of space. The idea of absolute personal freedom is an illusion. Word Origin Middle English (in the sense 'deceiving, deception'): via Old French from Latin illusio(n-), from illudere
BrE BrE//ɪˈluːʒn//; NAmE NAmE//ɪˈluːʒn//
Check pronunciation: illusion


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6198 Lockwood Ridge Rd, Sarasota, FL 34243
Call Club: 941-363-4500
Come and see us at Youfit North Sarasota on Lockwood Ridge Road! One of several amazing Youfit gyms in the Sarasota area, this fitness center is conveniently located on 6198 Lockwood Ridge Road, at the intersection of N Lockwood Ridge Road and University Parkway. If you are looking for a friendly relaxed place to workout, come and see us in the same center as Parkway 8 Cinema and Tuesday Morning.
Although our members are diverse, everyone has the same goal - to get fit and healthy in a place where everyone fits in. We have been providing top-quality service and a non-intimidating atmosphere to our members since November 2009. The ever helpful and fun team at Youfit North Sarasota will keep your workout satisfaction to the max. Come check out Youfit North Sarasota and let our staff help YOU!
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Because Kim rose to fame portraying "flower boy" characters in K-dramas such as Boys Over Flowers and Mischievous Kiss, many suggest his image reflects a desire to escape from modes of masculinity based on a "pretty boy" appearance. . . . However, an examination of Kim's concepts reveals a range of images that go beyond the extremes of "flower boy" and "beastly" masculinities. . . . Read more at Hallyu Harmony!
Tag: images
Shine On: Glamour, Image and K-pop
Visuals are an important part of K-pop, and understanding them is crucial to understanding the meaning of K-pop and its spread globally. In addition to music videos, images that accompany promotions for music releases, photo shoots featured in magazines and endorsements for an array of … Continue reading Shine On: Glamour, Image and K-pop


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Small Strongyles
- Apr 1, 2000
- Topics:
There is increasing confusion over the parasites known as small strongyles. In the early years of parasite control, small strongyles were thought to be of little consequence to the health and well-being of the horse. After effectively controlling large strongyles and other common internal parasites in horses, researchers discovered that small strongyles cause much more damage than previously imagined; damage that can lead not only to poor performance, but to death in extreme cases.
We went to career-long parasite re-searcher and American Association of Equine Practioners member of 28 years John Paul, DVM, MS, to ask some basic questions about small strongyles. What we found out will help you understand this complicated world of worms a little better. You should discuss deworming options with your veterinarian; different species of parasites cause problems in different areas of the country, and the world. A practitioner who is taking care of a number of horses in your specific locale is best able to see what is happening, and adapt what he sees to a program for your individual horse.
Q: What are small strongyles?
A: They are a group of parasitic worms living in the cecum and large colon of the horse. There are about 40 species of small strongyles throughout the United States and the world. They belong to a family known as cyatho-stomes, all of which have a similar life cycle.
Small strongyles are the most numerous parasite of horses. If you were to open a normal horse, you would find many more small strongyles than any other parasite--tens of thousands to hundreds of thousands in some cases.
Most horse owners will never see an adult small strongyle in the feces of a horse. They are hair-like in diameter and only about a half-inch long. (The larvae that hatch in the fields are, of course, much smaller.) Don't expect to see dead worms in the manure after you deworm your horses for small strongyles.
Q: What is the typical life cycle of a small strongyle?
A: Because of the multiple species, there are some variations in the length of the life cycle. Six to 12 weeks is the normal range from the time an adult lays eggs until the next generation is able to lay eggs.
The adult stays in the horse's intestine. There can be 2,000 strongyle eggs per gram of feces in a horse with a severe infestation. There are 454 grams in a pound, and a horse can produce 30 pounds of manure per day--that's a lot of contaminated pasture!
It should be noted that a fecal egg count doesn't tell us the adult population, however. Not all adults lay eggs every day. So, we can't say if the horse has 2,000 eggs per gram of feces that it has "this number" of adults.
Once the eggs are on the ground they hatch and develop into larval stages depending on climatic conditions. If it is warm and moist, they develop rapidly. If it is cold and dry, they lay around and don't do anything (a lot like a seed for a plant that doesn't sprout unless conditions are right).
Eggs may not hatch and larvae might not survive when climatic conditions are very hot and dry or severely cold.
As small strongyles are growing up, there are first, second, third, and fourth stage larvae. If the larvae reach the third stage and are ingested by a horse, then the larvae can cause infection and proceed with the life cycle. If the horse picks up a larvae in the first or second stage, then nothing will happen--it won't grow and mature.
Once the third stage larvae are ingested, they pass through the stomach and go to the lower intestines (primarily the cecum and ventral part of the large colon). At that point, something tells them to burrow in to the wall of the intestine.
Not too long ago, we didn't think it was too harmful because the larvae were just in the intestinal wall; now we know they can cause damage to the horse.
Part of the life cycle is for the larvae to become encysted in the intestinal wall. That is when a fibrous capsule forms around them (like a cocoon). Under normal conditions, they develop through the early third stage, to a later third stage, and then to a fourth stage while encysted in the gut wall. Then they emerge, come back into the lumen (intestinal space), and become egg-laying adults. The amount of time these stages take is varied.
Owners need to understand that when horses are grazing every day they are continually picking up larvae at the same time other small strongyles are developing in the intestinal wall and coming out a few at a time. This is like dripping water into a bucket with a hole in it--water runs out the hole a little at a time so the bucket is never full.
The encysted stage is a normal part of the life cycle, and under normal circumstances it does not cause a lot of problems to the horse. The exception is if the gut wall becomes full of these encysted small strongyle larvae. Then it will interfere with absorption of nutrients. That is a function of severe parasitism.
Another aspect of the life cycle is the ability of the early third stage larvae to go into an "arrested" stage of development called hypobiosis. In this situation, the larvae decide not to develop. They can stay in that arrested stage for weeks, months, or even years.
Then, when the larvae get some kind of signal--probably from the environment--they all start developing again at once, and they all emerge at once. This causes severe problems for the horse, and even death.
Remember the water bucket? It's like that bucket had the hole plugged, water kept dripping in to fill it up, and suddenly the bucket was tipped over and all the water came out in one big splash!
This is the most severe situation this parasite can cause and is characterized by profuse diarrhea, rapid weight loss (several pounds per day), and can lead to death due to dehydration and weight loss.
The good news is that this scenario doesn't happen very often. The bad news is that no one knows when it will happen.
It shouldn't be overlooked, how-ever, that the mild situation occurs more commonly. I'll suspect a performance horse with a dull or shaggy hair coat (of having small strongyles). He doesn't have that nice bloom, and his performance isn't up to par--he is beaten in races, or isn't doing well in events. He's got "ADR," ain't doin' right. That probably is due to an accumulation of cysts in the gut wall interfering with absorption, but we don't know that for sure. In some horses, a few encysted larvae deciding to come out at once could be enough to upset the balance of the gut in that horse.
A lot of things can cause "ADR," but we know that one of those things is parasites.
Q: What is the difference between the early and late third stage larvae?
A: The early third stage larvae is the only stage that has the ability to go into arrested development.This is the time when it is important to select optimum parasite control procedures.
Q: How can we detect small strongyles?
A: We can determine if a horse has adult cyathostomes because they lay eggs, and a veterinarian can run a fecal exam. We don't know about the larvae because they are immature and are not laying eggs. And we don't know if a horse has encysted larvae or not.
If you have adult small strongyles, you know they've gone through the life cycle and that horses are picking up the larvae in the field. But, you don't know if any of them are in an arrested stage.
Q: Why do some larvae develop normally and others go into the arrested stage?
A: We think it is because of climatic conditions outside the horse. Think of it this way: If a horse in the northern United States has an adult small strongyle that lays eggs in winter, then the eggs might not survive until conditions are right for the life cycle to continue. If it were late fall, a heavy frost could kill the eggs and larvae, and the life cycle couldn't continue.
So, in late fall something triggers larvae to encyst and wait until spring to develop, when the life cycle can continue outside the horse. No one has collected data to know exactly how climate affects small strongyle development.
At the University of Kentucky, larval cyathostomes were diagnosed as the cause of death at the diagnostic lab 45 times in six years. That's more than seven cases a year. The horses ranged in age from six weeks to 33 years, but they primarily were adults.
Q: How can we get rid of encysted small strongyles?
A: Become familiar with the life cycle, and become familiar with the active ingredients in your dewormer. Then you can determine which products affect the early third stage larvae. That is the only stage in which they can enter the arrested development. Currently, fenbendazole is the only anthelmintic (dewormer) that is recognized by the FDA to be effective against early third stage larvae, but that drug must be given at a larvicidal dose. That is 10 mg/kg of body weight of fenbendazole daily for five days. (The usual de-worming dose is 5 mg/kg once.) Fenbendazole also kills late third stage larvae and fourth stage larvae.
Moxidectin has label claims against late third stage and fourth stage larvae. Ivermectin is effective against fourth stage larvae, but not early or late third stage larvae. All of these data are cited in scientific literature.
Pyrantel tartrate is a daily anthelmintic that can be top-dressed on the feed. If a horse consumes a daily ration, it will kill the infective third stage larvae before it goes into the gut wall. The important note here is that you have to assume the horse is picking up larvae every day in the pasture. Thus, if he misses a day of his dewormer, then the larvae picked up that day can get into the gut wall.
You can give fenbendazole on top of the daily pyrantel tartrate or any other dewormer. Your veterinarian can help you decide when would be the best time to treat your horse. In most northern climes (considered by one parasite researcher to be from the Ohio River Valley to the north), that time would be November or December. As you go south, the time the encysted larvae would be expected to have an abrupt development would shift earlier in the year.
In the dry Mid-South and Southwest, summer is the worst time for survival on pasture, so you get a different development. These are assumptions and are not based on research in the horse. There is a worm in cattle that has a life cycle very much like the small strongyles in horses, and much research has been done on that parasite. Based on that research, we assume this is what to expect in horses.
Q: Does fenbendazole trigger the encysted small strongyles to come out and kill them, or does it kill them in the gut wall? Can that "kill-off" cause any problems in a heavily infested horse?
A: Fenbendazole, at the larvicidal dose, kills the early third, late third, and fourth stage larvae in the gut wall. No problems have ever been reported due to a massive killing of larvae.
Q: Are there any other specific scenarios we need to be concerned about with small strongyles?
A: Some parasitism in animals is probably good because there is some immune response in the horse to parasites. There is the possibility that some young horses which have been on a daily dewormer consistently are "too clean" of parasites. (Daily dewormers are shown to kill 80% or more of the parasite population in the horse.) That young horse might be sold at auction or privately and pick up small strongyles at the sale grounds or in its new environment. If the new owner does not use a daily dewormer--or if the animal misses a few days of dewormer--then the young horse could become overwhelmed with small strongyles because his immune system won't be offering much protection.
The take-home message here is not to count on any one product all of the time. Some products are not effective on tapeworms, others aren't effective on bots, and still others don't control all larvae stages of small strongyles. This is why you need a veterinarian's input to develop a deworming program that actually protects your horse!
By Kimberly S. Graetz With John Paul, DVM, MS
About the Author
Kimberly S. Brown
Kimberly S. Brown was the Publisher/Editor of The Horse: Your Guide To Equine Health Care from June 2008 to March 2010, and she served in various positions at Blood-Horse Publications since 1980.
Related Content
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Japan's Nuclear Troubles: What is Radiation's Effect on Horses?
Fenbendazole: Better Treatment for Fighting Resistant Ascarids (AAEP 2010)
Researchers: Flexion Tests Target Fetlock Joint
Horse Owners Advised to Prepare for Hurricane Earl
POLL: Colic Surgery


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Lot 83: 5 archaic bronze spear finial on Lucite stand
Important Chinese Antiques and Fine Jewelry Auction
by International Auction Gallery
October 24, 2016
Anaheim, CA, USALive Auction
Past Lot
Looking for the realized and estimated price?
Description: 5 archaic bronze spear finial (6.33"L - 9.7"L) on Lucite stand
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- 1a person who gives a lecture She's an excellent lecturer.
- 2 a person who teaches at a university or college on a temporary basis He's a lecturer in French at Princeton.
nounjump to other results
Check pronunciation: lecturer
Definition of lecturer noun from the Oxford Advanced American Dictionary


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CBS Sports' Clark Kellogg Breaks Down Indiana-Wisconsin Big Ten ClashCBS Sports' college basketball analyst Clark Kellogg discusses Indiana's chances of upsetting Wisconsin in Madison this Sunday.
Goodyear Cotton Bowl Betting Preview: #15 Western Michigan vs. #8 WisconsinThe Broncos look for their first undefeated season in program history but face a tough task against a stout Badgers D.
Four Big Games To Watch This College Football SaturdayFour Top 10 teams face stiff challenges this weekend that could affect their hopes of a playoff spot.
Wisconsin's Road To The NCAA TournamentNational Player of the Year Frank Kaminsky, fellow first-round draft pick Sam Dekker, and other key players are gone, but the Badger train keeps rolling.
Wisconsin Beats Michigan, Is Amazingly In Second In The Big TenMichigan remains interesting. It's 20-10 with victories over Texas, Maryland and Purdue
Kentucky 74-73 Over Wisconsin, To Play For TitleAaron Harrison hit a 3-pointer with 5.7 seconds left to lift Kentucky to a one-point victory over Wisconsin.
Wisconsin Beats Arizona 64-63 In OT In West RegionFrank Kaminsky had 28 points and 11 rebounds for Wisconsin, rallying the Badgers to a 64-63 overtime victory against Arizona to advance to the Final Four.
Wisconsin Routs Baylor 69-52 To Reach West FinalBen Brust hit three 3-pointers and scored 14 points for the second-seeded Badgers who jumped to a 14-point lead in the first half and never let up on the overmatched Bears.
Michigan Upsets No. 3 Wisconsin 77-70Caris LeVert added 20 for the Wolverines (13-4, 5-0 Big Ten), who held on for their first road win at Wisconsin since 1999 after nearly squandering a 15-point lead.
Ole Miss Stuns Wisconsin, Wins First NCAA Tournament Game Since 2002Marshall Henderson shook out of a shooting slump and scored 17 points in the second half, leading 12th-seeded Mississippi past No. 5 Wisconsin, 57-46, on Friday, giving the Rebels their first NCAA Tournament win since 2002.
Spartans Hang On To Beat Badgers 49-47Keith Appling scored 19 points and Branden Dawson added 18 to lead No. 13 Michigan State to a 49-47 victory over Wisconsin on Tuesday night.
Michigan State, Wisconsin Rivalry Good As Big 10 GetsWhen it comes to Big Ten rivalries, however, there's none better than the Spartans vs. the Badgers.


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TMZ reports that Janowicz has filed legal documents asking for a divorce on the grounds of irreconcilable differences. The documents also say that the couple has been separated since November 2013.
Interestingly, this isn't the first attempt at divorce for the couple. De Ravin filed for divorce only six months after the wedding, back in 2007, but she never served her spouse with divorce papers for a two-year period. Janowicz got those legal documents in 2009, accompanied by a public announcement of divorce.
They did not do so in 2009. Now, that seems to have changed.
In addition to playing Belle on "Once Upon a Time," de Ravin is known for starring roles in "Lost" and "Roswell." Janowicz had roles in "Charlie's Angels: Full Throttle" and "The Chumscrubber."


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マスプロ電工 3分配器 全端子通過型 双方向・VU・BS・CS 2600MHz対応 SP3CAD [MP0894]
Shopping > AV equipment, camera > TVs > Antennas > OtherK-material-shop
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Please visit Y! Shopping for more about the product.
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- Author: Jan Ormerod
- Format:Paperback
- Publisher:Oxford University Press
- Published:06 January 2005
Sorry, there are currently no sellers for this product.
Product description
- Total Pages: 32
- Genre: Picture books
- Illustrations: in full colour throughout
A lively, noisy, funny text that encourages very young children to walk and talk like the animals - including waddling like a penguin, stomping like a rhino and jiving and jiggling and jumping and wiggling to the monkey bop! Hugely entertaining with plenty of scope for interaction and play.
Author's Biography
Written by Jan Ormerod who has also written If You're Happy and You Know It! for OUP. Other titles by Jan include Peekaboo and Rockababy among many others. Illustrated by Lindsey Gardiner whose other books include Here Come Poppy and Max; Goodnight, Poppy and Max; Not Fair, Won't Share - a Pinky and Blue Story. She lives in Dundee, Scotland


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More Videos...
Celica GTS vs. Prelude
Celica GTS and Prelude go at it, they were both basically stock. They just had an intake, the celica has a TRD Exhaust thats aboout it. It was a best out of 3 Celica-1 Prelude-2 Winner= PRELUDE
Nissan GTR vs Honda CRX
Nissan GTR vs Honda CRX at RaceLegal.com at Qualcomm Stadium in San Diego. 1/8 Mile drag race. Watch in HD.
Mazdaspeed 3 vs Mustang GT, 350Z, SRT-4, Prelude, and others
Bolt-on MS3 on 235 street tires. DA was over 3,000, so everyone was slow.


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Published on April 15th, 2011 | by Guest Contributor2
Insteading Insight: Open-source blueprints for civilization
Pysicist-turned-farmer-turned-social entrepreneur Marcin Jakubowski is finally starting to get some wider recognition for his incredibly innovative, ambitious, and potentially disruptive Open Source Ecology project.
I first met him when he presented the still-nascent idea at Noisebridge in SF some months ago, and I'm incredibly impressed at how polished his message has become. Take a look for yourself!
Source: Marcin Jakubowski: Open-sourced blueprints for civilization | Video on TED.com


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July 22 I can't wait to get a hold of mine.
July 22 I can't wait to get a hold of mine.
No, it doesn't have a linear regulated psu. It will run on either USB or battery power.
To be frank, I never heard any noise from the switch mode PSU packed with other iFi gear. While it is not as quiet as a very expensive linear regulated PSU, it is still far cleaner sounding then most switch mode PSU out there, and definitely well under the audible range. Check this out: http://ifi-audio.com/wp-content/uploads/data/ULNAdapter.pdf
Also it is worth noting that the ULN wall adapter doesn't power the iUSB directly. There is extra circuit inside iUSB to further regulate and filter the 9V from the ULN adapter down to the 5V line for USB power.
What a result! I might see if I can pick one up on Tuesday!
The global launch has been rescheduled to July 28 due to last minute code changes which is already finished and the units are already being shipped to the distributors as we speak. That is my current understanding.
28?? I knew it was moved due to the increase in its power output but I thought it was moved to 22… damn it… my bad guys ONE MORE WEEK… ughh… I got my own hopes up with misinformation
Yes another week.. I am waiting on mine also. When IFI increased the power output it was decided that code changes will be needed. IFI even show a small sample of the code here on Head-Fi.
This sounds like a classic example of a buffer under-run. This stuttering issue can be caused by many things. Sharing USB with other devices, bad cables, hub issues, background process. If you set J.River buffering of 500ms with large buffers. Tried setting IFI ASIO buffers to the max and extra safe. Nothing is sharing the USB bus that the IFI Nano is on. Try memory playback setting in J.River. These are just few of the things you can try. A native 4xDSD file of 3 mins is about a bit more than 500megs and that far amount of data to transfer from the hard drive to the USB pipeline without stuttering. It is like streaming a bit faster than Blue-ray video on USB. You doing the same thing when you converting to 4xDSD in realtime. The slowest J.Mark speed I have ever seen for DSD playback is 2500 reliably but it sounds like you are converting to 4xDSD in realtime. A JMark of 3000 or better is what the developers of J.River like to see for DSD playback. The J.Mark score is just a guide.
If all fails you can try to use J.River offline conversion tool found under advance tools section of J.River. To see if you get better results.
Yes with JRiver most of the audio processing is done with using just one thread. I like that because you will run into issues with micro stuttering like on my Ethernet port for DLNA which is set for load balancing and off loading for server needs but not good for streaming on my previous setup that was with a slower 4 core CPU. Sometimes you may run into issues with CPU parking and unparking in some cases. With the 4xDSD you ran into the max of your CPU can handle in your case. Have you tried to turn off speed step in the BIOS if you have it? Sounds like you still converting PCM to DSD. Have you tried using DSD files in bit streaming mode?
With my old setup I was running into 31% load on the CPU but it was the spikes I was concerned about. Not a problem with copying files but near the edge of what my old setup can do with continuous data streaming.
Thanks for you advice. Firstly, the latest version of JRMC seems (not sure) to reduce the stutter. Yes, playing from memory too reduces it. As for USB loading, it doesn't seem to be an issue since 1) DoP has higher overheads (when compared to Native 2xDSD) and 2) when streaming DSD256/4xDSD, there is no problem and is very smooth. As for USB bus, there is only the nano iDSD; no other USB port is connected at all.
I agree with the buffer underrun diagnosis. What I don't understand is why DoP is fine while native stutters.
In any case, I will be upgrading from the machine in about 6 weeks time; I've ordered the i5/8GB version of the Surface Pro 3. Let see how that baby performs.
Curious, but how do you use the iDSD in DSD mode with PCM content? I'd like to do the same to produce the best SQ.
JRiver is another good one to use with the iDSD
Hey guys!
Just picked up a Nano iDSD and I really like it.
My only issue is that it is waaaay to loud with my Focal Spirit Professionals. If I try to go any lower, the device will click off, but any higher and it's borderline uncomfortable.
I remember reading something about a line attenuator that ifi sold, but i can't find anything on their website about it. Any ideas?
Thanks guys,
For the pair of external cable attenuator dongles, contact an official reseller of iFi audio products-
received mine from Avatar Acoustics.
Fantastic, thanks dude!


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Man of Steel
The Tortured
Black Christmas
X-Men: The Last Stand
Wrongfully Accused
All Aaron Pearl films
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
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Robert Redford, 71, is officially off the market.
And he's married a woman 20 years his junior!
Not that it matters much at this stage of life. Plus the lovebirds have been living together since the '90s at his 5,500-acre Utah ranch.
The Sundance Kid married his longtime girlfriend, German artist Sibylle Szaggars, 51, Saturday at the luxury Louis C. Jacob Hotel in Hamburg, Germany.
Pastor Frank Engelbrecht of Hamburg's St. Catherine Church, told People that the couple wanted the ceremony to be "intimate."
The bride wore a champagne-colored gown.
Redford chose a white suit.
Redford, 71, was previously married to Lola Redford from 1958 until their divorce in 1985.
They have three children.
The marriage was not a surprise.
Sibylle and Bob got engaged last March.
The Oscar-winning actor told the German magazine Bunte:"'We are engaged and
very happy with that. She [Sibylle] is my fiancee and that says
everything, doesn't it?"
To see photos of his new bride, keep reading …
Wow. Sibyille looks so nice and normal. And kinda like the runnerup in the Allison Janney lookalike contest. First prize went to Allison Janney.
Congrats, Bob and Sibylle!
More Redford Dish:
Robert Redford and his friend Paul Newman.
Photos: WireImage, Associated Press


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Office 2003
Microsoft Office is an office suite of desktop applications, servers and services for the Microsoft Windows and OS X operating systems, introduced by Microsoft on August 1, 1989. Initially a marketing term for a bundled set of applications, the first version of Office containedMicrosoft Word, Microsoft Excel, and Microsoft PowerPoint.
Over the years, Office applications have grown substantially closer with shared features such as a common spell checker, OLE data integration and Microsoft Visual Basic for Applications scripting language. Microsoft also positions Office as a development platform for line-of-business software under the Office Business Applications brand. Office is reported to now be used by over a billion people worldwide.
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With a horseshoe buckled ankle strap and pointy toes, the Nicolette 45mm Ankle Strap block heel in saddle suede boasts classic elegance with a contemporary twist. The addition of metallic elements and hardware lends an edge but maintains a level of sophistication.


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|"Lionel Cons (JIRA)" <j...@apache.org>
|[jira] [Created] (APLO-72) client-individual ack mode is not supported
|Thu, 11 Aug 2011 05:57:27 GMT
client-individual ack mode is not supported ------------------------------------------- Key: APLO-72 URL: https://issues.apache.org/jira/browse/APLO-72 Project: ActiveMQ Apollo Issue Type: Bug Reporter: Lionel Cons The current Apollo snapshot does not support the client-individual ack mode although it is mentioned in the user manual, in the "Reliable Messaging" section. FWIW, it is also defined in the STOMP 1.1 spec. Using it, we get: "Unsuported ack mode: client-individual". (yes, there is a typo here...) More confusing, the code contains other ack modes which are not documented: {code} val ACK_MODE = ascii("ack") val ACK_MODE_AUTO = ascii("auto") val ACK_MODE_NONE = ascii("none") val ACK_MODE_CLIENT = ascii("client") val ACK_MODE_SESSION = ascii("session") val ACK_MODE_MESSAGE = ascii("message") {code} Could client-individual be supported and all ack modes documented please? -- This message is automatically generated by JIRA. For more information on JIRA, see: http://www.atlassian.com/software/jira
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Pressure Cooker
Commitment, long hours and sustained drive are what "drill sergeant" Wilma Stephenson extracts from her culinary arts class. In a high school where less than 65% of students graduate, Stephenson's driving hand and her students' determination enable 11 members to attend top cooking schools with a staggering $750,000 in scholarship money.
- Director: Jennifer Grausman and Mark Becker
- Country: USA
- Year: 2008
- Runtime: 99
- Rating: MT
- Genres:
- Art/Literature,
- Documentary,
- Female Filmmaker
- Programs:
- Documentary Spotlight


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Fruit Times
We collected data on performance of strawberry cultivars in the second harvest year of a plasticulture planting at the Penn State South East Ag Research and Extension Center in Manheim, PA.
Research in the college helps shape the apple industry.
Do you think older strawberry cultivars tasted better than the newer cultivars?
Moldy core is characterized by the growth of fungus mycelium within the apple fruit seed cavity, without penetration into the flesh of the fruit.
We heard and saw many problems with calcium deficiencies in commercial orchards this past year. I thought it would be a good idea to review how the 2016 growing season may have impacted those problems.
The Horticultural Research Institute, the research foundation of AmericanHort, is pleased to announce the release of Best Management Practices (BMPs) for Bee Health in the Horticultural Industry.
There is not a strong signal that the dry fall weather in the Southeast tips the scales toward a wetter or drier late winter-early spring in the Northeast.
Penn State Extension has planned nine educational meetings for commercial tree fruit growers this winter. The regional meetings are being held all across the state. A statewide "Pruning by the Numbers," demo is also scheduled.
I spent most of the summer writing a review paper on apple rootstocks and came across quite a bit of information that might be of interest to commercial fruit growers.
A new Sustainable Agriculture Educator, Megan Chawner, joined Penn State Extension in Lehigh and Northampton counties the beginning of December.
There is a mystery surrounding rapid apple decline/sudden apple decline of young, dwarf apple trees. For the last several years, there have been many reports in Pennsylvania and, most recently, in the Northeast and states south about unusual sudden decline of young, dwarf apple trees.
Sanitation is the best offense for disease management, especially when it comes to canker removal.
The Penn State Extension Tree Fruit team has created new videos for Spanish speaking fruit growers.
We collected data on performance of sixteen cultivars or advanced selections of strawberries in the second harvest year of a matted-row trial. Some were great, and others had a few issues.
You may be receiving an email or a letter from Penn State in the coming weeks. You need to take action in order to continue receiving updates and alerts from Extension.
In general, apples matured slightly earlier than normal this year.
Agricultural businesses and pesticide applicators in 15 counties can dispose of unwanted pesticides safely and easily in 2017 through the Pennsylvania Department of Agriculture's CHEMSWEEP program.
More than 300 people attended an update meeting about the invasive insect, the spotted lanternfly, on October 27, 2016 in Bally, PA.
After a busy harvest season, there are still several jobs to be done and one of those important jobs is pruning.
Portable equipment can help producers, including small-scale and local farmers, get products to market quickly.


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Skip to comments.Scientists remove amyloid plaques from brains of live animals with Alzheimer's disease
Posted on 10/15/2009 7:52:05 AM PDT by decimon
New research in the FASEB Journal suggests that manipulation of the brain's own immune cells with IL-6 could lead to reversal of Alzheimer's disease pathology
A breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's Disease that actually removes amyloid plaquesconsidered a hallmark of the diseasefrom patients' brains. This discovery, published online in The FASEB Journal (http://www.fasebj.org), is based on the unexpected finding that when the brain's immune cells (microglia) are activated by the interleukin-6 protein (IL-6), they actually remove plaques instead of causing them or making them worse. The research was performed in a model of Alzheimer's disease established in mice.
"Our study highlights the notion that manipulating the brain's immune response could be translated into clinically tolerated regimens for the treatment of neurodegenerative diseases," said Pritam Das, co-author of the study, from the Mayo Clinic in Jacksonville, FL.
Das and colleagues made this unexpected discovery when they initially set out to prove that the activation of microgila trigger inflammation, making the disease worse. Their hypothesis was that microglia would attempt to remove the plaques, but would be unable to do so, and in the process cause excessive inflammation. To the surprise of the researchers, when microglia were activated by IL-6, they cleared the plaques from the brains.
To do this, the researchers over-expressed IL-6 in the brains of newborn mice that had yet to develop any amyloid plaques, as well in mice with pre-existing plaques. Using somatic brain transgenesis technology, scientists analyzed the effect of IL-6 on brain neuro-inflammation and plaque deposition. In both groups of mice, the presence of IL-6 lead to the clearance of amyloid plaques from the brain. Researchers then set out to determine exactly how IL-6 worked to clear the plaques and discovered that the inflammation induced by IL-6 directed the microglia to express proteins that removed the plaques. This research suggests that manipulating the brain's own immune cells through inflammatory mediators could lead to new therapeutic approaches for the treatment of neurodegenerative diseases, particularly Alzheimer's disease.
"This model is as close to human pathology as animal models get. These results give us an exciting lead to newer, more effective treatments of Alzheimer's disease," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study demonstrates that investment in experimental biology is the best way to approach the challenge posed by an aging population to the cost of health care."
Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fasebjournalreaders.htm. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB). The journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information. FASEB comprises 22 nonprofit societies with more than 80,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB advances health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and collaborative advocacy.
Details: Paramita Chakrabarty, Karen Jansen-West, Amanda Beccard, Carolina Ceballos-Diaz, Yona Levites, Christophe Verbeeck, Abba C. Zubair, Dennis Dickson, Todd E. Golde, and Pritam Das. Massive gliosis induced by interleukin-6 suppresses A deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. doi:10.1096/fj.09-141754 ; http://www.fasebj.org/cgi/content/abstract/fj.09-141754v2
Too bad Obamacare will make all that a moot point. Just withhold fluids and nutrients and the "problem" will be "solved." Never waste a good crisis.
The new procedure will be too expensive for 0bamaCare.
There is also research showing that L-carnitine prevents the accumulation of amyloid plaque. The best dietary source of it is beef.
Who pays for this type of research under ObamaCare???
(Answer: no one)
That's precisely my point. Not to mention that researchers won't be looking into developing these types of treatments if no one can make any money from them. But, thank goodness we'll still have politically-driven, government-funded research - and we all know how effective that is.
Thanks for the link. Alzheimers is in my family, yet hope it is not in my future. I drink lots of coffee in a day, so it is good to know it may help.
I bought it at VitaCost.com.
It was the cheapest I found.
If caffeine will do it then I should be protected for the next few hundred years.
Thanks for the info.
Remember No-Doz? I think it was 100% caffeine.
I am curious how many freepers are supplementing with No-Doz, or with generic tablets of caffeine -- have any of you seen any newer discussions about this?
I was surprised to learn on another website, one dealing with side effects from drugs, that overuse of No-Doz is associated with diarrhea, which surprised me, because even though I've read lots about caffeine, I'd never come across that as a normal side effect of too much caffeine.
I haven't been able to get past 2 tablets of either the generic variety or of the brand name No-Doz. Two pills is my current tolerance. Each pill contains 200 mg. of caffeine, and I also drink several cups of coffee each day.
Although I'm a long term coffee drinker, the very first time I took a No-Doz, shortly after the research with mice & caffeine & Alzheimer's Disease came out, I was UP ALL NIGHT LONG, wide wide awake & alert.
So, for a while I started breaking up the hard tablets, so that they'd have a better chance of dissolving and entering my system long before 3 am.
Are any of you now using pill-form caffeine as a result of this research?
Thank you.
BUMP for later reference
Posting to this thread for quick cross reference of another thread on this same topic.
I should be safe for the next few lifetimes.
There's no results at google for the word 'caffeine' nor the phrase 'alpha lipoic' at "The Natural Path dot COM.
Google Search http://www.google.com/search?hl=en&num=50&ie=ISO-8859-1&q=site%3Awww.the-natural-path.com%2F+++%22alpha+lipoic%22++caffeine+
I pinged you to the other messagethread where research is in that scientists have recently reversed Alzheimer's Disease in lab animals by using on them what is the equivalent in human terms of 5 or 6 cups of coffee per day, depending upon the brew & roast.
That's hard to say -- different coffee beans, different coffee roasts, different methods of preparing the coffee can result in significantly different amounts of caffeine.
I was absolutely shocked, as a life long coffee drinker, to stay WIDE awake ALL NIGHT hyper-ALERT and unable to sleep the first day that I took one little No-Doz tablet, which simply contains 200 mg. caffeine... supposedly the amount in 1 or 2 cups of coffee, depending upon the brew.
That website doesn't say caffeine is dangerous. I pay fairly close attention to that kind of research and have seen nothing on caffeine. Good luck in your quest.
1000 mg gives me heartburn, but 600 mg works fine.
Whether it is helping with my memory or not...
...I can't remember.
Medical research would be devastated by Ubamacare.
lol, me too. I don't take NO DOZ, I do want to sleep a little bit.
Thank you for sharing, and I'm sorry about the late reply, after I read your posting, I had a difficult time re-locating it in My Comments, in order to reply.
I do fine with 200, and not so bad with 300 -- but two mornings ago I swallowed two No-Doz for 400 mgs. total, and obviously they didn't dissolve in my stomach -- but later on around 2:30 am when they apparently did dissolve, I was WIDE awake, and hypervigilent for HOURS, unfortunately too physically tired to get up and do something useful, but mentally really 'wired.' On occassion, I also get the diarrhea, and once or twice had minor heart palpitations - speeding racing, thump-thump, while going up a flight of stairs, I know its a typical side effect of "too" much caffeine.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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19 New Featured Sources on the B2B Marketing Zone
thought I would take advantage of the power of the system to let you know about these new sources, what topics they tend to write about and some of their recent top posts. Writing on the Web ( Ning Advertorial Business Blogging Online Marketing Linkedin Landing Page ). Dianna Huff – B2B Marcom ( Small Business Newsletter Email Campaign Facebook SEO Budget Writing ).
Blogging Benchmaks: In Search of the Missing Metrics
B2B Marketing Savvy
Measurable site hits have grown to 1000+/week; . Five core contributors: writing, editing. Acronyms: B2B Marketing Is All About Acronyms So We Made Up Our Own… SWAG (Some Wild Ass Guess)… KISS (Keep It Simple Stupid)… SWOT (Strengths/Weaknesses/Opportunities/Threats)… . All these I highly value but the ramp is very slow compared to site traffic itself. pages viewed, time on the site, etc. Measure this by pure numbers, and by whether well-known, well-respected other sites are willing to connect. Welcome!


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Foyt: Conway goes for it, pays the price at Baltimore GP
My driver Mike Conway knows all about the highs and lows of racing; he had a roller coaster ride this weekend in the Baltimore Grand Prix.
My driver Mike Conway knows all about the highs and lows of racing; he had a roller coaster ride this weekend in the Baltimore Grand Prix.
The Go-Pro Indy Grand Prix of Sonoma weekend was pretty frustrating for Mike Conway and my ABC Supply race team.
The IndyCar team owner also expresses excitement over running African-American Chase Austin in next year's Indianapolis 500.
Mike Conway was in the top three in all of the practice sessions until we started having problems with the fuel pressure before qualifying.
How happy were we when Mike Conway finished third in the Honda Indy Toronto? Pretty damn happy. As for the huge penalty, I'm angry. Period.
Weekends like this bug me to death. It figures when you want to run really good, it all falls apart. That was the case at Iowa Speedway.
The return of the Izod IndyCar Series to the Milwaukee Mile is one that could be considered a qualified success for the ABC Supply team.
The Firestone 550 at Texas Motor Speedway proved that Indy cars don't have to give up their oval track heritage for the sake of safety.
IndyCar returned to Belle Isle for the first time since 2008, and for the ABC Supply team, it was the first race we finished since April 1.
The Indianapolis 500 is the world's most famous race and because of that, the questions raised beforehand took on a greater importance.
We went into the Long Beach Grand Prix feeling pretty good because Mike Conway likes the track and he drove a great race there last year when he won.
Entering Indianapolis Motor Speedway is still a thrill for me even though I've been doing it for almost 60 years.
Foyt: I'm not so sure the good old days were all that good, but they seemed to be a lot more fun.
Sunday's 15-car pileup was a terrible disaster that left behind a family, a fraternity and a sport devastated by that loss.
The Kentucky Indy 300 was one of those races where everything fell against us. It seemed like one step forward, two steps back.
The Grand Prix of Baltimore turned out to be a great inaugural event for the IndyCar Series.
Unfortunately, things got pretty ugly on race day in New Hampshire, starting with the weather. And it went downhill from there.
We had a little bit of luck in the Honda Indy 200 at Mid Ohio this past weekend mainly because we were prepared for it.
The Honda Indy Edmonton ran on a new track at the City Centre Airport. In fact, we landed on the runway that we raced on last year!


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Eva from the Aztec dance group "Xolo, Sacred Dance"
Photo taken at the Dia de los Muertos procession in the Mission (San Francisco) on Nov 2, 2007. For more info on this event, please check out my Dia de los Muertos series.
Shot on film (Kodak T-Max 3200 pushed +3 stops to about ISO 25600).
More images of ▶


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New personal work to test out Redshift with a relatively heavy scene, as well Redshift proxies. As one would expect the interactivity of IPR did slow down, but easily managed by using display layers to hide/show objects. Render time for 4k was about 90 minutes with dual Pascal TitanX cards, although I did crank settings higher than likely necessary since it was for a still. This is still super fast, especially since both 3D fog and DOF are on! I'll note that the DOF is what requires higher sampling, so if I were to do the DOF in post the render time would likely be cut in half... 45min for 4k? Pretty darn cool for a scene like this... I still haven't played with Redshift's AOVs, so this is a straight 32bit EXR render with just a little tweaking in Photoshop with the Camera Raw filter. I also set-up a bunch of Megascan materials that are ready to go for future projects, using several of their rock and leaf materials for this scene. Anyhow... has been a great experience so far switching over to Redshift and GPU rendering!
Founder/Director, Gnomon
A couple weeks ago I decided to try out GPU rendering. After doing some research and talking to a few people, I was steered towards Redshift. Several studios have been using it and it seemed worth trying out. Was simply curious. A couple years back I switched from Mental Ray to V-Ray and the idea of converting my library of assets, again, was not super appealing. But, fun to try something new nonetheless. Anyhow, after a weekend with Redshift... holy $@#*! Running on a single 980 card it was insanely fast. IPR became useful for complex scenes including fog and DOF, seemingly about 10x faster than Vray. And easier... less fuss to manage sampling as the speed allows for the use of high rates and Brute force. And a bunch of other things but to sum up. It is cool and I've 100% switched. Just spent a couple weeks converting my library. Also upgraded my machine from a single 980 to dual TitanX cards. Yay for nVidia... and Redshift!
Here's a quick test I did after converting my library. IPR constantly refreshing as I imported random assets, set up a couple lighting styles with DOF and fog... all in about an hour. Really fun...
Regrading and Uprezzing
Decided to spend some time over the winter break going through older experiments that had potential, but were only rendered at 1280x720 to see what I could do with them. In the process I also decided to uprez some of the images in the 3D stills gallery to 4k. I recently got a new 30" monitor and some of the images in the gallery looked a little small! The images below are the result of some of the time spent adjusting textures and regrading / color correcting. Of the few I played with, I think I like these two the most...
And... I have a YouTube page. Added some misc animations as well as an entire tutorial on the making of Dirge: a lecture from the Gnomon Workshop. Still not much there for now, but hopefully I can record some more casual tutorials and things to put in there if time permits. Ultimately there are some things I'd be happy to share in regards to process that don't really need to be an 'official' Gnomon Workshop title. So we will see... but for now... it's a start!
New image... inspired by Titus Canyon in Death Valley. This summer I spent some time experimenting with Photogrammetry and created a bunch of assets such as tree trunks, logs, rocks and cliff faces. Fun to have an excuse to get in the car, find cool things and take a bunch of photos in order to build models with PhotoScan. This image incorporates a few, specifically the tree on the right, a couple small logs and rocks on the ground and the cliff wall on the left of the image... so about 35% of the screen real estate. The rest is made in Maya, ZBrush and a little bit of World Machine. Textures are a combo of 3D and some Photoshop overlays just to be quick about it.
Ladder Canyon: R2's journey to Mecca
This is a five mile hike near Mecca, CA... in the canyons east of the Salton Sea. The R2 that you'll spot is actually mine from when I was a kid... i.e. I've had that little dude since 1978...! He's a little battered and missing his middle foot, but holding on nonetheless... given that he's 37 years old. Oi... that's weird. Anyhow, this was an awesome hike, with various forks in the trail that were marked by arrows made out of rocks by past travelers. Without them it would have been easy to get very very lost... So thank you... whoever you are.
Death Valley
New galley in the photography section! Decided to try my hand at shooting bracketed photos for HDR tonemapping... so I drove out to Death Valley on a four day exploration. Album also includes some things along the way such as Vasquez Rocks, Fossil Falls and Mojave. Definitely was an inspiring journey... makes any attempt at digital landscape making seem a little futile. Heh. Turns out that HDR tonemapping is really fun but man... definitely just stepped into a rabbit hole! Time to figure out where i'm heading to next...
New DVDs on Creating Terrains
I just released a couple new DVDs on working with satellite data to create terrains using a variety of tools: Google Earth, The National Map, GlobalMapper, ZBrush, Maya, Photoshop and Mental Ray. There's over ten hours of lecture over the two titles, so a lot of info!


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Inspired by Victoriana fashion, this beautifully crafted LBD comes adorned with a sultry off-the-shoulder lace trim. Gently fitted for a curve-contouring finish, emphasise the ultra-romantic vibe even further with berry lips and high-shine heels.
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Couldn't move my arms in this dress although it looked really good


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Call Southland Protective Investigation Services whenever you are looking for a professional and trustworthy private investigator. We are the premier Houston, Texas private investigator and security firm with decades of combined experience. Southland Protective Investigation Services is a full service private detective investigator agency that delivers first-class confidential investigative results and security services. With our diverse team of professional private investigators, we are capable of conducting investigative work throughout the entire state of Texas. In addition, our network of investigative associates reaches across the country and around the globe. We are a locally veteran owned and operated, licensed and insured team of professionals with prior military and law enforcement experience, dedicated to the success of each assignment. Southland Protective Investigation Services provide both a personal and professional touch that ensures your needs are being met, discreetly and efficiently. Our private investigation services range from civil and criminal domestic investigations. We offer tenant and employee background checks, photo and video evidence surveillance and loss prevention. Whether you suspect a cheating spouse, warehouse theft, fraud or any other wrongdoing, Southland Protective Investigation Services can assist. Our security services range from trained armed and unarmed security officer protection as well as and vehicle and foot patrol; all for long and short term contracts such as event security. Over the last decade and a half, Southland Protective Services have helped thousands of people get answers to questions that only seasoned private investigators have the skills to obtain.
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Small Glass Bottles: Colored Green, with Cork Tops
Product ID : 1218-225
How will you fill these green, small glass bottles? Our green craft bottles are perfect for larger bottle pendants, memory crafts, storing tiny embellishments, and more.
These small glass bottles measure almost 2 inches tall, not including the cork, and are approximately 7/8 inches in diameter. Corks are included with these green glass bottles.
Product Type : Glass Bottles
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2 small glass bottles per package.


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To make reservations by phone, dial freephone 0800 221 222 in the UK, 1 800 409 929 in Ireland, or view our regional telephone reservation numbers.
Make yourself at home during your visit to Russia at the Moscow Marriott Hotel Novy Arbat. Our spacious, thoughtfully appointed hotel rooms each come equipped with comfortable bedding, a flat-screen TV, and high-speed Wi-Fi access, while our elegant hotel suites feature scenic views of Moscow's Novy Arbat Street. We offer an impressive selection of amenities, including a fitness center. Enjoy a drink at the lobby bar, or dine in style at GostinaЯ, which offers business lunches every week day, and take advantage of free Wi-Fi access in the public areas of the hotel. Guests interested in hosting an event here in Moscow can take advantage of our hotel's flexible, modern meeting venues and our location in the city center, close to many corporate headquarters. No matter your reason for visiting our hotel, our ideal location on historic Novy Arbat Street allows for convenient exploration of the best of Moscow. Join us at the Moscow Marriott Hotel Novy Arbat for a unique combination of style and substance.
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I've used soapnuts for about 12 years now, and I love them. They make my clothing feel fresh and clean, and they are so cheap per wash. One 500 gram bag will last me six months.
Jody Allen has already written two great books on saving money, but this one will be more awesome - written from someone that had to live on just $50/week for four years, she shares how to do it - step by step, where to shop, how to shop, recipes to make and everything in between!
This Bottle was really good and made feeding time a breeze. There was some concern around leaking but personally this wasn't a hassle at all.
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Adds two enhanced commands to replace wordpress 'previous post' and 'next post' functions. Works with WordPress 2.8+.
Extract, upload to the plugins folder of your wordpress install, activate.
How to use:
This plugin adds two specific functions to your wordpress install:
my_prev_post_link and
These two functions are very similar to, and support the same variables of the original wordpress tags they are meant to replace (please refer to the relative wordpress codex pages for their use),
previous_post_link and
My replacement functions anyway come with two additional variables:
$string_lenght and
$pre_link. Not that you really needed to know how they were called.
The first variable indicates the maximum length for the title (default is 22 characters). The second the string to be displayed before the link (only if the link itself is present).
So, you'll just have to replace
<?php next_post_link(); ?> in your template with
<?php my_next_post_link() ?>, obviously indicating between the brackets the variables you want to specify. Again, refer to the wordpress codex for usage of variables: only keep in mind that my two additional variables,
$string_lenght and
$pre_link, are the second last and last variable of the function.
Requires: 2.0.2 or higher
Compatible up to: 2.8.4
Last Updated: 7 years ago
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Product Code: SHGLXD1-Z2
Manufacturer: Shure
Free mainland UK shipping available for this product
Our Price £228.99INC
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The GLXD1 bodypack transmitter is included in SM and Beta Digital Wireless Systems. It combines automatic frequencyThis is how many times a sound or radio wave oscillates in one second.Read moreGo to the glossary management with true digital diversityWireless "diversity" receivers feature two separate antennas for consistent signal reception.Read moreGo to the glossary for a rock-solid wireless signal with exceptional digital audio clarity.
Shure proprietary Lithium-Ion rechargeable batteries provide up to 16 hours of continuous use. Depending on the operation mode, you will get up to 16 hours of continuous use and has an operating range of 60m.
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Contact us now to discuss your requirements or to request a quotation. Additional discounts may apply for educational establishments or size and value of order.
Purchase orders can be sent directly to email@example.com or apply for your cash or credit account here. Terms and conditions will apply.
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What kind of suggestions has anyone got for creating more shade
areas for hostas, or partial shade areas? Has anyone tried putting vines
(such as virgina creeper) on wooden rose harbors or fences to create shade?
Maple trees and similar trees, seem to have big root systems. I
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My Briard (my shaggy-haired french sheepdog), also needs more shady areas.
peri, Ontario, CANADA, mailto:firstname.lastname@example.com
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E-flite Fuselage Set
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This is a replacement E-flite Fuselage Set, and is intended for use with the E-flite UMX Sback 342 3D electric airplane.
This product was added to our catalog on October 17, 2012.


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Dry Pak Floating Waterproof Flip Phone Case
Key Features
100% waterproof
Seals out water, sand, and dust
Operates simply with a twist of the knobs
Case floats
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Our Price $12.99
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Availability: Sold Out
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Product DescriptionA 100% waterproof case for your electronics. Operates phones, GPS's, cameras, PDAs, and VHF radios through the case. Seals out water, sand, and dust with a simple twist of the knobs. All cases float. Guaranteed submersible. Folds closed with the flip phone inside. Lanyard and spring hook. 4" x 6" folded.


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Current time:0:00Total duration:1:45
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Fraction word problem: spider eyes
Sal solves a fraction word problem about spider eyes. The fractions have common denominators. Created by Sal Khan.
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- Help! I'm Haunted – Dealing with Ghosts is now available on Amazon Kindle.
- Spirit Remediation interview on HCR – Feb. 2014
- 2 hour interview on Spectrum Radio Network – March 13 2012.
- HGR Featured in Houston Chronicle – Oct 2011
- HGR Featured in YourHoustonNews.com – Oct 2011
- Volunteers Page – Interested in helping with our cause?
- HGR Facebook Page – Keep up with the latest news.
Our Mission:
We serve the citizens of the Houston area through educating the public and our clients about the paranormal phenomenon and assisting / counseling and intervening in times of spiritual crisis.
HGR is a private investigative group dedicated to studying paranormal phenomenon in the greater Houston area. We operate both as an investigation group and non-denominational ministry focused on education in regard the paranormal and spiritual issues, specializing in spiritual crisis intervention.
The confidentiality and privacy of our clients are always respected to the utmost. Our services are offered totally free of charge as they are primarily for research purposes and to assist families and individuals in need of information, assistance and guidance where paranormal phenomenon are concerned.
We make it a point of not charging clients for our consultations and services and often supply initial supplies for free in some cases. Obviously this is not free. If you would like to donate something to offset expenses we would greatly appreciate that. We are not a 501c as cash rarely changes hands within our organization so donations can be made directly to group leadership here:
Tony Barton & James Sangster, HGR Directors, discuss our methods:
Listen to an interview with Tony Barton and James Sangster discuss Spirit Remediation. They discusses HGR's method and approach to dealing with traumatic hauntings and how our approach differs from other groups.
Lori West, the Lone Star Medium:
Lori discusses her approach to helping clients and her experiences as a life-long medium in an HCR interview. For more information Lori please, her website, book and private bookings please see our staff page.
Need Our Help?
Think your house may be haunted? Not sure what to do? We can help.
We've helped dozens of clients successfully deal with a hauntings for over a decade. Our common-sense approach focuses on dealing with the haunting itself and gives you a clear step-by-step approach to re-claim your home. We always operate free of charge and we coach you through the entire process. Visit our prospective client page to learn how we operate and how to get started.
Important Note:
All members of HGR are ordained ministers through a non-denominational church. Any and all advice given by an investigator should be considered spiritual counseling / advice from clergy unless otherwise stated. Under no circumstances should any advice given be considered legal or medical advice unless the consulting member also holds a relevant professional certification.
HGR is also one of the founding groups for the Houston Paranormal Alliance and a member of the International Ghost Hunters Society (IGHS) and the South Texas Ghost Hunters Alliance (STGHA).
Proud supporters of: ParanormalSocieties.com | paraseek.com | theshadowlands.net


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C#/C++ Full Time Contract Programmer With Great UK Company!
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Project Description
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- Professional UK Telecom company
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- 07-09-2014, 01:50 AM Thread Author #1
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Picture backups
My S4 Mini was forever backing up my pictures, which is great, but I really don't know to where! The phone broke and was sent for repair, got it back yesterday and it was swiped clean. New motherboard. Does anyone have any idea where the photos could have gone? So sad...
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Re: Picture backups
Welcome to Android Central! How do you know it was backing up pictures? Was it backing up to Google+, or was it some Kies thing? Try checking your Google+ Photos page on the web, and look for an Auto Backup folder.
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