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1 Park near La Junta, Colorado
Rocky Ford, Colorado 10.97 miles NW
Las Animas, Colorado 17.89 miles NE
Ordway, Colorado 19.82 miles NW
26680 Highway 50 La Junta, Colorado 81050 (map) | (719) 384-9580
Sites: 42 | Latest Rate: $38.00 | 26 Reviews
|Clean Restrooms:
|Clean Showers:
Sep 2016 - $38.00
We actually paid $5 extra for 9/2 due to holiday weekend. Didn't realize it would be more. We were looking for a place to stay on our return trip home so we wouldn't encounter a lot of holiday traffic. We drove to John Martin Reservior State Park to check out the campground. We would prefer it over this park next time we are in this area. - GT and DK
Sep 2016 - $40.00
A standard KOA experience. Good enough but nothing special. Note to be careful of the water. Ours ran rusty, (straight from the spigot), for about ten gallons of flow before becoming clear. We were grateful for our water filtration. Some kind prior neighbor left dog waste just near my hookups. That told me that maintenance does not check sites after folks leave. - Elmo and Gracie
Aug 2016 - $41.00
In 3 years of extensive RVing, this is our first KOA. As seniors we do not need the extensive amenities/cost. This was, however, THE choice in La Junta. The park was fine on all levels although a tad noisy at times. Site was level, utilities were fine. Had no WiFi at the site the first day. Second day went to rec room and had slow but usable service. That evening and the next morning it worked. When it did not work I went to the office twice and one of the young people was supposed to come to our trailer. Never showed up. This was a bit frustrating. - gumper


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Immediate incentives and referral opportunities are a few elements that can help, a study finds.
Kevin Woodward
A recent study of 30 online retailers in the United Kingdom by online marketing platform Owned it found that many of them use order confirmation pages to entice future sales from existing shoppers and to gain new customers.
Owned it analyzed order confirmation pages for social media elements, if an immediate incentive, such as a discount on a future purchase is offered, if there is an opportunity to refer the purchase to friends, and if longer-term incentives are offered if a consumer takes an action such as signing up for a retailer's e-mail newsletter. The study also looked at the order confirmation page length.
Based on the presence of these elements, Owned it ranked Amazon.com Inc., Marks & Spencer, New Look Retail Group Ltd. and House of Fraser Stores Ltd. as the best in maximizing their order confirmation pages. Amazon is No. 1 in the Internet Retailer Europe 400; Marks & Spencer, No. 19; New Look, No. 160; and House of Fraser, No. 100.
Overall, the analysis finds that 53% of the retailers use social media buttons on their pages, but only 13% displayed them prominently. Many placed the buttons below the fold and often in black and white.
Owned it defined money off of the shopper's next purchase as one type of immediate incentive. Among e-retailers in the study, 56% offered some form of incentive for shoppers to return, and 30% offered an immediate reward, such as a discount on the shopper's next order. It defined longer-term incentives as those requiring an action, such as signing up for a newsletter.
Sharing purchases also can extend beyond social media networks to include shoppers e-mailing friends about their recent purchase, Owned it says. "Word of mouth—both online and offline—is still high on the list of how people hear about products and services," Owned it says.
The survey also found that a majority of retailers—53%—kept their order confirmation pages to fit the size of the computer screen, eliminating the need for the shopper to scroll to view all of the elements. "Users engage more with the content above the fold," Owned it says. "Hence, the effectiveness of the campaigns on the order confirmation page will be higher if users can access the content without scrolling."

subset: commoncrawl


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Opportunities at Attakkalari
Unique opportunities to work with India's leading contemporary dance organisation - Attakkalari Centre for Movement Arts, Bangalore. Be part of innovative, path-breaking and interdisciplinary projects involving contemporary dance, and gain unparalleled skills and experience.
Production Manager
The Production Manager will administratively lead production related works at Attakkalari. Responsibilities include overseeing the production works of the Attakkalari Repertory Company (an internationally reputed contemporary dance group) in their performances, Attakkalari India Biennial (South Asia's largest and most important festival of contemporary dance) as well as those of emerging choreographers as part of FACETS Choreography Residency and South Asia Platform. He/ She will lead activities related to new productions, rehearsing the existing ones and touring performances to other cities in India and internationally.
Responsibilities include but not limited to: Strategic planning and leading production related works; management of budget and resources as well as personnel including artists and technical staff; coordinating with marketing and media teams; liaising with funding bodies, arts organisations, national and international festivals, government agencies, business houses and the general public.Candidates must have the initiative, independent decision making capabilities, creativity, leadership qualities and entrepreneurial flair to work in this managerial position. They should be team players and able to devise strategic projects for the organisation. Arts Management skills including writing of project proposals and reports, adequate computer skills, knowledge of budgeting and financial control are essential. Candidates with awareness of the arts scene in India and internationally, particularly those pertaining to the performing arts and contemporary dance will be preferred. Prospective candidates should have at least 2 years of experience in a similar position with managerial responsibilities.
If you feel you are the right fit, then please apply with a recent CV outlining your academic qualifications and work experience along with a statement of interest. Salary will be commensurate with qualifications, experience and capabilities. Outstation candidates can request for a telephone or Skype interview prior to a face to face meeting.The last date for applications is 9th July 2016.
Admin Executive
Responsibilities include attending enquiries (phone, email and walk-in), drafting and sending/distributing communication materials for students, maintaining files on matters pertaining to the students and faculty, scheduling and coordinating admissions and classes for students, faculty and allocation of studio spaces.
The candidate should be flexible to carry out different tasks in the office and be fluent in English and Kannada. Excellent verbal, spoken and written communication skills, computer skills, customer service and data management skills are required. Qualifications: Bachelor's Degree
Should be available to work 6 days a week including Saturday and Sunday - one of the weekdays will be a holiday. The initial contract is for 2 years with a probation period of 3 months. Salary will be commensurate with qualification, experience and capabilities.
Join the Attakkalari India Biennial 2017 team!
- Managing the Application process from end to end
- Correspondence with all selected candidates and mentors about contracts and logistics
- Managing rehearsal schedules and coordinating with Mentors and collaborators
- Coordinating Tech requirements, production needs and publicity materials for the final showcase during the festival
- Maintaining budget and accounts for the programme
- Developing the structure of the programme with the core team
- Managing the Application process from end to end
- Coordinating Tech requirements, production needs and publicity materials for the final showcase during the festival
- Maintaining budget and accounts for the programme
Associate Artist
The Associate Artiste Programme, an initiative of the Attakkalari Centre for Movement Arts is a professional development initiative for practicing performing artistes who aspire to further their career in dance. Applicants should have a proven track record and must be based in Bangalore.
Opportunities: Under this initiative, chosen dance artistes will get priority consideration for upcoming national and international projects. They will also be provided a platform to choreograph their own pieces which will then be considered for Platform Performances, Sanchaari Performance Tour and other exchange programmes of Attakkalari. Apart from a monthly stipend, they will receive additional incentives such as discounted rates for several of Attakkalari's services including availing studio space; participating in master classes and other short courses; and receiving technical and management support for productions and tours. Association with Attakkalari will also facilitate interaction with some of the most acclaimed artistes in contemporary dance and allied fields from around the globe.
Selection Process: Attakkalari is looking for passionate and committed individuals who have professional experience and track record in performance/teaching/choreography. Dance artistes with at least +2 or equivalent academic education, in addition to sufficient training in contemporary dance and allied subjects will be considered for this position. In the case of performers, they should have performed in a minimum of 2 professional contemporary dance works. In the case of the teaching portfolio, a minimum of 2 years' experience in conducting classes for both professional dancers as well as amateurs of different age groups, students of schools and colleges, special groups such as corporate employees etc is required. Choreographers should have choreographed and performed in a minimum of 2 professional dance pieces.
How to apply: Artistes with relevant experience can send an email to email@example.com, clearly expressing their interest in the role, and how their skills and experience meet the requirements. The application can focus on performance, teaching or choreography, or all the three categories. It should be accompanied by an updated CV, a DVD or links to videos of related work/s, contact details, current commitments and time availability of the applicant. Shortlisted candidates will be called for an in-person interview and a contact session before making the final selection. Attakkalari's decision on the selection will be final.
Commitments: The programme requires the artiste to undertake/participate in a minimum of two activities each month. They could either be performances, teaching assignments or choreographic works. Attakkalari has to be informed 30 days in advance about any other engagements that could affect the assigned activities or responsibilities. Selection for and participation in any engagement of Attakkalari is under absolute discretion of the relevant Project Managers/Artistic Director. Their decision will be final.
Remuneration: Selected artistes will receive a fixed stipend of Rs. 3000/- per month, in addition to separate fees for each assignment, which will be decided depending upon the nature of the project. All direct local travel costs will also be reimbursed.
Attakkalari has opportunities for people in Bangalore and elsewhere, who are interested to learn a new trade, gain experience and be part of a committed team in delivering many exciting projects. You should be adventurous, a team player and always ready to learn and try out new things. It offers the opportunity to work in various contexts with several artists, professionals from other disciplines, and national and international organizations broadening your horizon.
Click here to submit your application online
For further details of the job opportunities and to register your name please contact firstname.lastname@example.com


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Hello my friends/knexers. I recently built and modded DJ Radio's Halo 2 Battle Rifle Replica. I got it to work, but the looks of mine were butchered too much to look like the gun. It still looked great and all; and worked fairly good. Props to DJ Radio for his awesome Halo 2 Battle Rifle. Now to the Stats right?
Excellent power
Great range 85-105 ft
Removable mag
Fairly easy to maintain
Tactical rails
Just looks great
Mags can act a little funky
Credit to DJ Radio for his plain awesome gun.


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FREE SHIPPING on orders over $75.
Quantity Available:
Tom Dixon has a vast commitment to design creativity and a mission to redefine how products are made and sold. The Tom Dixon lighting and furniture collections reflect all of his cutting-edge design and manufacturing innovations, from the product's shape and form to the raw materials and production processes used.
The Hide Phone Case is available with the following:
- Material: 2mm thick Italian vegetable tanned leather
- Copper plated hardware
- Stamped and copper foiled logo
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Color: Grey, Ox Blood
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Manufacturer IDs: view
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The Blomus GENTS Flip Business Card Case protects business cards from damage while adding a smart, contemporary note to business networking events. The GENTS Flip Business Card Case features stainless steel.
To protect your tech, sometimes you need a thicker skin. The Tom Dixon Hide Tablet Case provides just that, made out of fine vegetable tanned Italian leather with a protective resonated backing. Copper plated Sam Brown fixings secure the flap ...


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Sesame Lemon And Curry Chicken Strips
|Low fat plain yogurt
|1⁄2 Cup (8 tbs)
|Mango chutney
|1⁄3 Cup (5.33 tbs)
|Chopped fresh cilantro
|2 Tablespoon
|Boneless skinless chicken breast halves
|Fresh lemon juice
|1⁄2 Cup (8 tbs)
|Sesame seeds
|3⁄4 Cup (12 tbs)
|Garlic cloves
|4 Large, minced
|Curry powder
|4 Teaspoon
|To Taste
|To Taste
Blend yogurt and chutney in processor.
Add cilantro and process 5 seconds.
Transfer sauce to small bowl. (Can be prepared 1 day ahead. Cover and chill.)
Arrange chicken in shallow dish.
Pour lemon juice over.
Refrigerate at least 15 minutes and up to 30 minutes, turning chicken occasionally.
Preheat oven to 400°F.
Lightly grease baking sheet.
Drain chicken.
Combine sesame seeds and garlic in shallow bowl.
Sprinkle both sides of chicken with curry powder.
Season with salt and pepper.
Press chicken into sesame seed mixture, coating completely.
Arrange chicken on prepared sheet.
Bake chicken until just cooked through, about 20 minutes.
Let stand 15 minutes.
Cut chicken crosswise into 1/2 inch wide strips.
Arrange chicken strips around edge of serving platter.
Place chutney dip in center and serve.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1275 Calories from Fat 486
% Daily Value*
Total Fat 57 g88.1%
Saturated Fat 9.3 g46.3%
Trans Fat 0.1 g
Cholesterol 206.3 mg68.8%
Sodium 1875.3 mg78.1%
Total Carbohydrates 95 g31.6%
Dietary Fiber 22.7 g90.8%
Sugars 42.3 g
Protein 107 g213.1%
Vitamin A 47.7% Vitamin C 126.5%
Calcium 130.9% Iron 127.4%
*Based on a 2000 Calorie diet


text: As one of the less-heralded architects of '90s hardcore rap, Queens native producer-MC Havoc (born Kejuan Muchita) never received the same level of credit accorded to Wu-Tang Clan's RZA, but his productions on his albums with Prodigy as Mobb Deep -- especially 1995's classic The Infamous -- were among some of the starkest, grimiest, and deceptively musical beats of the era. Havoc didn't keep his work strictly to Mobb Deep releases. He granted early productions to Nas' It Was Wri... Read more


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With the Oscars now just a week-old memory, the time has come for the final
edition of this column (for this season). From the Toronto International
Film Festival's unofficial awards season kickoff in September to last
weekend's generally underwhelming ceremony, it's been six long months of
speculation and anticipation and we're ready to move on (as we're sure many
of you are as well).
There is one final column before letting
awards talk rest in peace until September. It's been an annual tradition
at Indiewire (and elsewhere) to take an ignorant stab at the following
year well before there's any substantial evidence in its regard (save recent Sundance and Berlin premieres "Boyhood," "Whiplash" and "The Grand Budapest Hotel," the latter of which — given its glowing reviews and very promising box office so far — could very well make for Wes Anderson's first best picture nomination).
it's not always a total crapshoot. Last year, we did manage to properly
predict five of the nine best picture nominations and to get nine of the 20 acting nominees (though, granted, we also predicted "The Monuments Men" and "Labor Day" would get best picture noms). Which probably says more
about how extraordinarily predictable this all is than any sort of
skill, but still, before this column lies dormant until the fall…
let's give it another shot. No one's taking this too seriously. (Right?)
certainly plenty out there to choose from, including many folks who have had dates with Oscar in the recent past. Bennett Miller — whose previous two films "Capote" and "Moneyball" were both nominated for best picture — has "Foxcatcher," a film that was all over the version of this article last year before being moved to 2014 (it had even dropped a very promising trailer before the switch). Two-time best director nominee David Fincher ("The Social Network" and "The Curious Case of Benjamin Button") has his adaptation of Gillian Flynn's extremely popular novel "Gone Girl" — starring recent best director winner Ben Affleck.
Paul Thomas Anderson (who has yet to win an Oscar after four nominations) has his seventh feature film "Inherent Vice," which reunites him with his Oscar-nominated "The Master" star Joaquin Phoenix. Michel Hazanavicius is following up his Oscar-winning "The Artist" with "The Search," about woman who works for a NGO that forms a special relationship with a young boy in war-torn Chechnya (which sounds like it has Oscar written all over it, and stars previous nominees Bérénice Bejo and Annette Bening to boot).
"Chicago" director Rob Marshall has another big budget musical en route for Christmas with "Into The Woods." We don't know if its more "Nine" than "Chicago" but a cast including Meryl Streep, Johnny Depp and Emily Blunt can't hurt. And Stephen Daldry has "Trash," which follows follows three boys in a third world country who find a leather bag in trash — the contents of which plunge them into an adventure. Based on the book by Andy Mulligan (and co-starring Rooney Mara and Martin Sheen), "Trash" should not be discounted solely due to Daldry, who has directed four films in his career ("Billy Elliot," "The Hours," "The Reader" and "Extremely Loud and Incredibly Close"), every single one of which has been nominated for best picture or best director (or both).
There are also a few filmmakers oft (or always) ignored by Oscar that could make their way into derby. Tim Burton has seen his animated features get nominated, but his live-action work has yet to receive a best picture nod. That could change with "Big Eyes," a biopic of painter Margaret Keane (Amy Adams — more than overdue at this point) and the legal difficulties she had with her husband (Christoph Waltz), who claimed credit for her popular work. There's as JC Chandor, who was snubbed this past year for "All Is Lost." His 1980s-set family crime saga "A Most Violent Year" stars two more recent Oscar snubbees — Oscar Isaac and Albert Brooks — alongside Jessica Chastain. The Academy could make up for quite a bit if this gets nominated across the board.
They could also make a little progress regarding the criticism surrounding the lack of women nominated time and time again with Sarah Gavron's "Suffragette," a film about the early feminist movement in the UK that is written and directed by women (Gavron and writer Abi Morgan) and starring an almost all-female cast including the likes of Carey Mulligan, Helena Bonham Carter and Meryl Streep (again — here comes nomination #19?). Another female-directed film that could be a major player comes via a woman that has two Oscars — one for acting and one for her humanitarian efforts. Angelina Jolie's "Unbroken" — written by the Coen Brothers, no less — could be a major player with its chronicle of the life of Louis Zamperini (played by Jack O'Connell), an Olympic runner who was taken prisoner by Japanese forces during World War II.
And this list doesn't even mention new films from Todd Haynes ("Carol," starring the Oscar-winning likes of Cate Blanchett), Alejandro Gonzalez Inarritu ("Birdman," which could offer a comeback-making performance from Michael Keaton), Christopher Nolan ("Interstellar," with recent Oscar winners Matthew McConaughey and Anne Hathaway), Mike Leigh (who almost always seems to get a screenplay nomination, and could again with "Mr. Turner"), Jean-Marc Vallée (following up "Dallas Buyers Club" with an adaptation of Cheryl Strayed's memoir, starring Reese Witherspoon) and Tate Taylor (reteaming with his "The Help" cast members Viola Davis and Octavia Spencer for James Brown-adaptation "Get On Up" that stars "42" breakout Chadwick Boseman as Brown). Not to mention the many films that are not likely on anybody's radar just yet. So with that in mind, turn to the next page for our major category 2015 Oscar predictions, one year in advance, to be taken seriously by no one.
Best Picture
Big Eyes
The Grand Budapest Hotel
Inherent Vice
Into The Woods
A Most Violent Year
(Ten Alternates: Interstellar; The Imitation Game; Get On Up; Fury; Trash; Mr. Turner; Gone Girl; Whiplash; Boyhood)
Best Director
Wes Anderson, The Grand Budapest Hotel
Paul Thomas Anderson, Inherent Vice
JC Chandor, A Most Violent Year
Angelina Jolie, Unbroken
Bennett Miller, Foxcatcher
(Ten Alternates: Christopher Nolan, Interstellar; Richard Linklater, Boyhood; Tim Burton, Big Eyes; Rob Marshall, Into The Woods; Michel Hazanavicius, The Search; David Fincher, Gone Girl; Alejandro Gonzalez Inarritu, Birdman; Mike Leigh, Mr. Turner; Sarah Gavron, Suffragette)
Best Actor*
Steve Carell, Foxcatcher
Benedict Cumberbatch, The Imitation Game
Ralph Fiennes, The Grand Budapest Hotel
Oscar Isaac, A Most Violent Year
Eddie Redmayne, Theory of Everything
(Ten Alternates: Chadwick Boseman, Get On Up; Joaquin Phoenix, Inherent ViceChristoph Waltz, Big Eyes; Michael Keaton, Birdman; Robert Downey Jr, The Judge; Brad Pitt, Fury; Timothy Spall, Mr. Turner; Jack O'Connell, Unbroken; Brendan Gleeson, Calvary; John Lithgow, Love Is Strange)
Best Actress
Amy Adams, Big Eyes
Carey Mulligan, Suffragette
Rosamund Pike, Gone Girl
Reese Witherspoon, Wild
Michelle Williams, Suite Francaise
(Ten Alternates: Emily Blunt; Into The Woods; Felicity Jones, Theory of Everything; Berenice Bejo, The Search; Nicole Kidman, Grace of Monaco; Jessica Chastain, Miss Julie; Julianne Moore, Map to the Stars; Charlize Theron, Dark Places; Natalie Portman, Jane Got a Gun; Jennifer Lawrence, Serena)
Best Supporting Actor
Josh Brolin, Inherent Vice
Albert Brooks, A Most Violent Year
Johnny Depp, Into The Woods
Mark Ruffalo, Foxcatcher
J.K. Simmons, Whiplash
(Ten Alternates: Robert Duvall, The Judge; Phillip Seymour Hoffman, A Most Wanted Man; Ethan Hawke, Boyhood; Benicio Del Toro, Inherent Vice; Alfred Molina, Love Is Strange; Channing Tatum, Foxcatcher; Martin Sheen, Trash; Edward Norton, Birdman; Gary Oldman, Child 44; Christopher Walken, Jersey Boys)
Best Supporting Actress
Patricia Arquette, Boyhood
Jessica Chastain, A Most Violent Year
Viola Davis, Get On Up
Meryl Streep, Into The Woods
Kristin Scott Thomas, Suite Francaise
(Ten Alternates: Rooney Mara, Trash; Anna Kendrick, Into The Woods; ; Sigourney Weaver, Exodus; Reese Witherspoon, Inherent Vice; Helena Bonham Carter, Suffragette; Emily Watson, Theory of Everything; Octavia Spencer, Get On Up; Maya Rudolph, Inherent Vice)
Peter Knegt is Indiewire's Senior Writer and awards columnist. Follow him on Twitter here (where he promises to mention nothing Oscar-related until at least September).


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For example, if the pole or track is 50 inches, then select a curtain width of 100 inchesDue to differences in monitor settings, there may be a slight variation in color on screen,versus the actual material.
No one has consulted this product.


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Tenerife Highlights
Whether you're escaping for a weekend in paradise or visiting as part of a Canary Islands cruise, there's plenty to keep you busy in Tenerife. You can learn about the islands' unique history at the Museum of Man and Nature, admire the landmark Auditorio de Tenerife and Church of the Immaculate Conception, and tuck into traditional Spanish cuisine at one of the many restaurants. The capital is also linked by tram to neighboring La Laguna, where you can marvel at the colonial architecture and historic churches that line the UNESCO-listed Old Town.
Take in the best of Tenerife's rugged scenery with a trip to the top of the El Teide volcano, Spain's highest peak and one of the most iconic attractions of the Canary Islands. Whether you brave the steep hike or hop on the cable car, the views are spectacular, looking down over the surrounding Teide National Park, a UNESCO World heritage Site, and the neighboring Pico Viejo volcano.
And of course, with some of the most popular beaches in Europe, you can't come to the Canary Islands without adding sun, sea and sand to your itinerary.
Plan Your Trip
Top Tenerife AttractionsSee all
- 1 Teide National Park
- 2 Mount Teide
- 3 Auditorio de Tenerife (Tenerife Auditorium)
- 4 Church of the Immaculate Conception
- 5 La Gomera


text:
Paul Pierce Fires Back at Draymond Green
Paul Pierce fired back at Draymond Green with a pointed tweet.
Inside the Design of the Nike PG1
Designer Tony Hardman takes us behind the curtain for one of the Swoosh's most anticipated releases.
Draymond Green to Paul Pierce: 'You Thought You Was Kobe?'
Draymond talks some major trash to the Truth.
Hardly Home (But Always Reppin')
Wherever he decides to go next, Trevon Duval will be repping his often-overlooked home state of Delaware.
Kyrie Irving Covers 2017 All-Star Issue
Who better to grace the cover of this year's All-Star issue than the Cavs' clutch PG and Mr. All-Star Weekend himself, Kyrie Irving.
Serge Ibaka news. See the latest news and highlights for Serge Ibaka from SLAMonline.


text:
I vacuum a lot – because of the big hairy dog, the big hairy cat and the two young grandchildren who are crumb factories. Daily I drag out my medium-sized vacuum with the super long cord to vacuum up all the hair, crumbs and other miscellaneous floor clutter. But sometimes I just need to do a little clean up and the regular vacuum is a bit too much trouble.
Thanks to my daughter-in-law, I recently discovered a better way to do those little clean ups. Now, instead of dragging out the big vacuum with the super long cord, I pull out my Bissell 3-1 Vacuum. It's light weight and does a great job on those little clean ups.
I've also used it to sweep the indoor/outdoor strip of carpet in the garage, the rug in the laundry room and the rug on the screened porch. I don't vacuum those areas as much as I want to because the big vacuum is too much trouble. But this small vacuum made those chores much easier and quicker. I've also used the vacuum on the stairs and even on the furniture.
So if your vacuum is heavy and cumbersome and sometimes you need something smaller and easier for quick clean-ups, you might want to give this vacuum a try. I got mine at Wal-mart for $20 and it was worth every penny.
By the way, this is not a paid endorsement. I just like this vacuum and wanted to share it with homemakersdaily readers.
Latest posts by Steph Caldwell (see all)
- Planning With Stickers Isn't Evil - January 24, 2017
- To Spank or Not To Spank - October 5, 2016
- Slow Cooker Beef Stroganoff - October 1, 2016


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Northeast Region Highlights
Beyond the dam, a new vision for resilient communities
February 17, 2017 - By working to remove obsolete dams that can threaten wildlife and public safety, the Service and partners are helping communities realize a new vision of healthy, safe and connected river systems for people and wildlife.
The Wildlife Drive Reopens at Forsythe National Wildlife Refuge
February 13, 2017 - Forsythe National Wildlife Refuge's Wildlife Drive has reopened following extensive repairs from damages caused by Hurricane Sandy. Refuge officials say the repaired roadway will be more resilient to future storms and improve habitat for wildlife and the visitor experience.
Great Thicket National Wildlife Refuge gets its start in New York
Federal, state and local officials gathered Wednesday in Dover, New York, to mark the establishment of the Great Thicket National Wildlife Refuge through the U.S. Fish and Wildlife Service's first land acquisition for the six-state refuge, the 144-acre Nellie Hill Preserve donated by The Nature Conservancy.
$4.5 Million to Protect Coastal Wetlands in the Northeast
January 6, 2017 - Recipients of USFWS funding to protect coastal wetlands across the country include five projects in four Northeastern states. With wetlands under siege from increased development and sea-level rise, protection of these coastal wetlands is critical for wildlife and communities to thrive into the future. The funding comes through the National Coastal Wetlands Conservation Grant Program and will go to the following projects in the Northeast: Cape May Delaware Estuary in New Jersey; Great Bay Estuary in New Hampshire; Surry Coastal Ecosystem in Maine; and Buzzards Bay and Southshore Wetlands in Massachusetts.
|View Archived Highlight Stories


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Radisson Hotel Yuma
1501 S. Redondo Center Drive
Yuma , AZ 85365
With a location just three miles from Yuma International Airport (YUM) and a complimentary airport shuttle, the Radisson Hotel Yuma provides convenient amenities from the moment you arrive. Situated just off I-8, we offer easy access to the Marine Corps Air Station Yuma, Fortune 500 businesses like Johnson Controls and attractions like Yuma Palms Regional Center. Start each morning with a delicious free breakfast in our on-site restaurant, and bask in the glow of a desert sunset as you wind down the day in one of our sparkling pools.
See what our guests are saying about us.
Proud recipient of the
2015 President's Award
Hotel amenities & services
Catch up on work in our business center, stay in touch with family and friends with our free Wi-Fi, and maintain your healthy habits in our state-of-the-art fitness center. Additional amenities and services include:
Learn more about our hotel's amenities and services.
Our rooms
Our 154 hotel rooms combine contemporary furnishings with a lively color scheme to create a relaxing and rejuvenating experience. After a restful night's sleep on premium bedding, brew a cup of coffee while watching the morning headlines on a 32-inch HDTV. Standard room highlights include:
Visiting Yuma for work? Book your reservation for a Business Class Room, and take advantage of additional perks that include:
Where to eat while you're here
Before a full day of meetings or visiting local attractions, enjoy a complimentary breakfast at Market Grill, our on-site restaurant. From sizzling angus steaks to fresh entree salads, Market Grill also features savory selections of traditional American fare at dinner. For additional convenience, room service is available.
Our lobby bar offers more than 25 wines, award-winning martinis and classic cocktails served in a casual setting that is perfect for meeting with friends or colleagues.
Things to do in Yuma
Within a 10-minute drive of the hotel, you can explore the natural beauty of the Yuma Conservation Garden, wander through the history of Yuma Territorial Prison State Historic Park or play a round at Desert Hills Golf Course. We're also positioned close to some of the most popular local festivals and events. Don't miss these other favorites during your visit:
Yuma Palms Regional Center – Situated one mile from the Radisson, this shopping center features almost 500,000 square feet of major retailers, specialty shops, restaurants and entertainment venues.
Historic Yuma Theatre – Connected to stunning art galleries in the Yuma Art Center and offering 643 seats for shows, this historic theater offers guests the chance to interact with creative culture just over two miles from our hotel.
Quechan Casino – Head 10 minutes west on I-8, and experience the excitement of poker, blackjack, slot machines and more at this popular area casino.
Read more about our hotel's location.
Groups & meetings
When you host a business meeting or social gathering at the Radisson in Yuma, your event guests enjoy access to our business center and free Wi-Fi. With more than 3,000 square feet of flexible event space and a location close to the Yuma International Airport, our facility provides the ideal venue for your event.
Conduct a successful presentation with our available audiovisual equipment, host an exclusive team meeting in one of our customized meeting rooms or cater an elegant reception with the assistance of our friendly staff.
Learn more about our meeting rooms.
100% non-smoking facility
Hotel Convenient to Marine Corps Air Station Yuma
Radisson Hotel Yuma is pleased to serve the military. Centrally located, Radisson Hotel Yuma is the perfect location for every service member's needs—whether they are relocating to the area, traveling for work or on vacation.
Local Bases


text: How Fujifilm's Lusted-After X100 Camera Got Back On Its Feet Post-Japanese DisasterKat Hannaford6/30/11 4:00amFiled to: watch thisFujifilm x100 videoFujiFilmX100FujiFilm X100CameraCamerasPhotographyJapanEarthquakeJapanese disasterJapan disasterFactoryFactories10EditPromoteShare to KinjaToggle Conversation toolsGo to permalink While the subject of Fujifilm's propaganda video is sad (Japanese earthquake delays production of one of the finest cameras ever!), the production qualities of the video are simply hilarious. Anyone would think they were shooting Michael Jackson's last days. That's before it delves into almost biblical readings—"and on the twelfth day..." Advertisement Advertisement Whatever your thoughts on the documentary-style video, it does provide a unique look into the factory line, and how Fujifilm responded quickly to one of the worst natural disasters in history. [Foto Actualidad via PetaPixel] You can keep up with Kat Hannaford, the author of this post, on Twitter or Facebook.Reply10 repliesLeave a reply


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outta curiosity, which are the current production brands that are not made in China? or do certain brands make their cheaper models in China and the highend models in country of origin?
post #1 of 98
8/9/07 at 11:05am
Thread Starter
What makes it difficult is that so many of the major manufacturers are making some phones in their home country and many others in other locations. Many are "offshore" but in other countries, and many more are made in China.
The country of origin has no bearing other than to reflect the parent companies quest for unreasonable profits of course. China can produce products the equal to anywhere else in the world if the profit margin isn't the prime consideration.


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Call (888) 651-9785
Experience the fairy-tale beauty of Rothenburg on a full-day tour from Frankfurt. Travel into the heart of Bavaria to this treasured medieval city, renowned for its beautifully preserved homes and Renaissance attractions like the formidable town hall. Enjoy included access to St Jacob's Church or Rothenburg's Medieval Crime Museum, then stroll the town's cobblestone lanes and soak up the essence of small-town Germany.
July 2016
We were surprised to find that our tour was a private one aboard a small 8 seat Mercedes for just our family of 4 - a pleasant surprise. Our tour guide was phenomenal (Boris) with lots of local knowledge and perfect English. Rothenberg was beautiful - just like the pictures in a storybook.
March 2016
We had a great time and enjoyed the tour in Nuremberg and Rothenburg. Our tour guide was Peter and he is a great tour guide and very informative.
Two small towns are very beautiful and very well preserve. Highly recommended.
Rene Z USA
December 2015
Excellent day tour from Frankfurt. Driver and tour guide Peter was excellent and very knowledgeable of this gorgeous mediaval city in Bavaria.
November 2015
The trip was great. Was not so sure at the beginning at the Green Line Shop, but Oliver, our driver was an amazing guide. Rothenburg should not be missed and the price of the tour was more than fair. Amazing time, and was not overcrowded as some tours can be when traveling. Highly rate this tour 9.5/10.
November 2015
It is a wonderful little city. Germany has done well on keeping this place as it was. The sights, food, Christmas displays, and museums are just a few of the things I enjoyed about Rothenburg.
September 2015
great ville!
July 2015
Must see! We wish we spent more than the day in Rothenburg, it was amazing!
June 2015
Well worth doing Fabulous guide named George. Lots of. history and really quaint old buildings
April 2015
Highly recommended! Georgen is a wonderful and warm guide! He is pleasing and informative and it was a very enjoyable and relaxing trip!
April 2015
Boris was our guide on a personified tour to Rothenburg that was undoubtedly one of the highlights of our trip to Germany. His knowledge of the area and the easy manner in which he imparted it was exemplary for all local guides. We couldn't fault the seamless organisation of the whole day and would highly recommend this tour to any independent travellers. Rothenburg itself is a delight, of course.
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Elsevier Honored with Six PROSE Awards
SciVerse Hub, SciVerse Applications, and book titles in Science & Technology and Health Sciences recognized for innovation and achievement
SciVerse Hub, SciVerse Applications, and book titles in Science & Technology and Health Sciences recognized for innovation and achievement
Amsterdam, February 9, 2012 –Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announced that it has garnered top honors and recognition at the 2011 American Publishers Awards for Professional and Scholarly Excellence (the PROSE Awards). The annual PROSE Awards, established by the Association of American Publishers (AAP), recognizes high standards in achievement and innovation in professional and scholarly publishing by giving distinction to the best books, journals, and electronic content, as judged by peer publishers, librarians, and medical professionals.
SciVerse Hub, Elsevier's platform for search, analysis and research synthesis, and SciVerse Applications, tools that enhance the search and discovery experience, received awards for Best Multidiscipline Platform and for Best Innovation in ePublishing.
Elsevier's book publishing, encompassing print as well as online titles on SciVerse ScienceDirect, was also honored. Four Elsevier book titles won first place prizes in the following categories:
- Clinical Medicine: Diagnostic Imaging for the Emergency Physician, by Joshua S. Broder, MD, FACEP.
- Multivolume Reference/Humanities & Social Sciences: Encyclopedia of Adolescence, Editors-in-Chief: B. Bradford Brown and Mitchell J. Prinstein.
- Multivolume Reference/Science: Encyclopedia of Fish Physiology, by Anthony P. Farrell.
- Art Technique: Tradigital Blender: A CG Animator's Guide to Applying the Classic Principles, by Roland Hess.
Honorable mentions went to:
- Clinical Medicine: Imaging Painful Spine Disorders, by Leo F. Czervionke MD and Douglas S. Fenton MD.
- Economics: Handbook of the Economics of Education, Volume 4. Edited by Erik A. Hanushek, Stephen J. Machin, and Ludger Woessmann.
"It is an honor for Elsevier to be recognized by colleagues in the publishing, library, and medical industry for our meaningful developments towards the advancement of quality science, technology and medical information," said Suzanne BeDell, Managing Director, Science and Technology Books, Elsevier. "The PROSE Awards validate the excellence of our innovative technology platforms and book content and we are proud to be a valued contributor in the community."
Recipients of the 2011 PROSE Awards were announced at the Awards Luncheon on February 2, 2012 in Washington, D.C. A full list of winners can be found at www.proseawards.com.
About Elsevier
Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Research Intelligence and ClinicalKey— and publishes over 2,500 journals, including The Lancet and Cell, and more than 35,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group, a world-leading provider of information and analytics for professional and business customers across industries. www.elsevier.com
Media contact
Harald Boersma
Senior Manager Corporate Relations, Elsevier
+31 20 485 27 36


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News // 1 Articles
Home: A Memoir of My Early Years by Julie Andrews
15 Apr 2008 // 4:59 PM
Andrews still sings; fortunately, she also writes -- a good thing, because there are still four decades left to chronicle.
Acting legend Julie Andrews returns in Shrek the Third
18 May 2007 // 5:24 AM
LOS ANGELES -- PUBLICIST: "You're not going to write that you watched the Kentucky Derby in Julie Andrews' bedroom, are you?" JOURNALIST: "I wouldn't do


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Residents of Visions at the Shore are split on the best future for the senior housing complex.
While some continue to believe in the concept of a senior-only complex on Pitney Road, others have joined efforts with project owner Amboy Bank to ask the city to remove the senior designation and allow a proposal for a 400-unit complex for all ages instead. Visions is currently approved for 369 units for residents 55 and over.
Owners who support the change say the current plan will never come to fruition, and the new proposal would be their only chance to get out of their original investment.
But those who want to stay at the complex as it is say there will be enough interest to fill a seniors-only Visions as the market rebounds and the owners properly market the site.
Amboy Bank's application before the city's Zoning Board was finally completed Tuesday after six full meetings of testimony. Amboy attorney Jack Plackter reiterated to the board that the complex faces many hardships because the real estate market for senior housing is stagnant.
The board will vote on the plan at its Dec. 18 meeting. Some city residents have opposed the plan, saying the changes would cause a burden to the schools, and city services and add traffic on Pitney Road.
Amboy is asking the board to approve a plan for 400 units, including 60 affordable housing units, for the site. After approval, the bank would sell it to a developer to create the new plan.
"We believe ... it would be in the public's interest to approve this," Plackter said.
There are 42 units already built on the site — 17 of which have been sold — and the rest being rented by Amboy. In the past several weeks, Amboy has reached a deal with about 10 owners and is in negotiations with others to support the bank's plan, Plackter said.
The owners must vote to change the deed to lift the age restriction before the board makes its decision at the Dec. 18 meeting. Plackter said he expects a majority of the owners will support the bank's proposal before the vote is taken.
As owners of 25 of the 42 properties, Amboy has the majority vote, but Plackter said he expects a majority of the 17 other owners will also support their proposal.
Stephen Patron, an Amboy consultant, said the residents need to move on from Visions.
"They bought into a lifestyle. It's a nightmare. It's not going to change unless either we change it or the town changes it or both," he said. "Once you realize it's not going to be what you thought it would be, the next focus should be how do I get out of here? I can't wait 20 to 30 years for this lifestyle. How do I get out of here?"
The residents who are siding with Amboy said they lost their investment and are frustrated at the state of the complex. They said they have given up on the original idea of the complex and wanted an opportunity to leave.
Resident Lewis Leitner said Amboy's offer would make the owners whole.
"It wasn't going to move forward in any way, shape or form. We have to give up on that," he said. "There was no decision to make. Nothing was happening."
He said he bought his home in 2008 but said 2½ ago he wanted to leave. Leitner said the bank would give the owners options to relocate.
"You have a real estate market crash, and you realize you have no flexibility, and your home is essentially worthless," he said. "Until the bank gave us this opportunity."
Bernard and Barbara Roswell bought their home in April 2009 and originally fought the Amboy plan. But the couple said they have known for a long time the senior complex would not make it and reached an agreement with the bank.
"It's obviously not what we bought into," Barbara Roswell said. "We're trying to help it move along. It's been very difficult for us."
Resident John Douris said he cannot sell or get financing on his home and asked the board Tuesday to approve the proposal.
"This is our only way out," he said.
But others want to remain and said the Visions senior housing concept can still work. They said Visions has not done enough to market the complex.
Resident Bob Vargo, who said he was aware of only four residents with an agreement with Amboy, said the rest of the owners are still committed to living in a senior community.
"We love Visions, we love living in Absecon," he said. "It's wonderful. I have no intention of leaving."
Vargo said with the complex's proximity to Atlantic City there will be enough seniors to fill the complex.
"All you need is a few hundred baby boomers who want to be close to Atlantic City," he said. "Saying Visions will not fill is ridiculous."
Visions resident Tom Melchiorie said building 400 units at the site would be too much of a burden on the city.
"I'm concerned of the ramifications of what could happen here," he said.
Contact Joel Landau:
Follow Joel Landau on Twitter @landaupressofac


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Current Products
Oshawa, Ontario (Monday, November 9, 2015) – Chevrolet today confirmed that the 2016 Colorado two-wheel drive with the Duramax turbo-diesel will be the most fuel efficient pickup in Canada, offering a fuel consumption rating of 7.7 L/100km highway.
Oshawa, Ontario (Friday, July 31, 2015) – The fastest-selling truck in the market now offers an available turbo-diesel engine. The 2016 Chevrolet Colorado Duramax diesel takes midsize truck capability and efficiency to unprecedented levels.
DETROIT (Wednesday, October 29, 2014) – An adhesive used in production of the 2015 Chevrolet Corvette Stingray may help preserve a threatened bat species in North America.
Oshawa, Ontario (May 18, 2012) – With this weekend being the official start to the summer long weekend season, Chevrolet is reminding consumers of some easy ways to maintain their vehicles and drive smarter to help improve fuel efficiency and save money at the pump.
BEIJING – General Motors showed the company's vision of the Chevrolet EN-V 2.0 concept at Auto China 2012 today. It is an evolved design of the company's revolutionary mobility concept revealed at World Expo 2010 Shanghai.
Oshawa, Ont. (March 22, 2012) – Chevrolet and GMC announced details of General Motors' bi-fuel 2013 Chevrolet Silverado and GMC Sierra 2500 HD extended cab pickup trucks. Fleet and retail consumers can place orders late this year.
Oshawa, Ont. (Friday, March 16, 2012) – Just in time for St. Patrick's Day, Chevrolet is wearing its own green, with a concept performance car that would make any enthusiast green with envy, an upcoming mini hatch that wears a hot Jalapeno paint finish, and fuel-sipping cars that save green at the pump.
Toronto, ON, February 6, 2012—Bullfrog Power, Canada's 100 per cent green energy provider, and Chevrolet Canada, today announced the launch of the Chevrolet Volt Bullfrog Power Edition—Canada's first electric vehicle (EV) bundled with emissions-free, renewable electricity.
Oshawa, Ontario (November 5, 2011) - "GM Canada commends British Columbia for its new Clean Transportation Program, which will accelerate consumer adoption of green vehicle technologies like the Chevrolet Volt," said Kevin W. Williams, president and managing director, General Motors of Canada.
OSHAWA – Chevrolet confirmed today it will add a diesel variant to the Cruze lineup in North America in calendar year 2013. Diesel versions of the Cruze are currently being sold in Europe. Additional details on the Cruze diesel for North American markets will be released at a later date.
OSHAWA, On – Chevrolet Cruze customers can rest easy knowing the engineers who developed their car packed a wide variety of advanced fuel-saving technologies under the hood.
DETROIT – The 2011 Chevrolet Volt is the first electric vehicle to earn a five-star overall vehicle score for safety as part of the National Highway Traffic Safety Administration's New Car Assessment Program.
OSHAWA – When the Oshawa built Chevrolet Camaro Convertible sets the pace for the 2011 Indianapolis 500 this Sunday, it will showcase a top built to last a lifetime, operate worry-free and maintain the appearance of its Coupe sibling.
Toronto, ON (Thursday, May 26, 2011) – Chevrolet joined the Toronto Atmospheric Fund (TAF) today to announce its participation in FleetWise EV300, TAF's initiative to encourage commercial vehicle fleets in the Greater Toronto Area (GTA) to work collaboratively to purchase, drive, charge, evaluate and promote at least 300 plug-in electric vehicles by 2012.
OSHAWA – Oil-soaked booms from the Gulf of Mexico are providing more than enough recycled material to make a production year's worth of air-deflecting baffles for the Chevrolet Volt electric car with extended range, a positive outcome of the worst offshore oil spill in U.S. history.
OSHAWA– With gasoline topping $1.40 a litre, there are many ways to conserve fuel and save money. The Chevrolet Cruze relies on microprocessors in the brain of the compact car's fuel system to help.
OSHAWA – In auto production, more power, better fuel efficiency and fewer emissions rarely appear together. But the 2012 Camaro 3.6L direct injection V6 engine achieves all three by combining the exhaust manifold with the cylinder head into a single aluminum casting.
OSHAWA – With gas prices near or exceeding $1.40 per litre, the efforts of GM engineers to boost fuel efficiency on the Chevrolet Cruze Eco compact are adding up.
OSHAWA – Athletes understand that proper breathing is critical to maintaining peak performance under all conditions and so do Chevrolet powertrain engineers. Getting air in and exhaust gases out of the combustion chamber under all speeds and driving conditions is essential to outstanding drivability and fuel efficiency with low emissions.
DETROIT – Oil-soaked plastic boom material used to soak up oil in the Gulf of Mexico is finding new life as auto parts in the Chevrolet Volt.
Oshawa, Ontario (November 12, 2010) – The official fuel consumption numbers for the 2011 Chevrolet Cruze Eco are in and they deliver on Chevrolet's best-in-class promise, with a Natural Resources of Canada (NRCan) highway fuel consumption rating of 4.6 L/100km for manual transmission models.**
The oil pump in the engine of the 2011 Chevrolet Cruze takes a laid-back approach to its work, delivering the precise amount of oil needed during all driving conditions. That requires the engine to work less versus a conventional pump and ultimately saves fuel.
Detroit –OnStar is leveraging the power of Google technology to develop a number of new mobile app features that strengthen Chevrolet's commitment to providing Volt customers with the most connected vehicle experience possible.
Larry Nitz, General Motors electric and hybrid powertrain engineering executive director, provided an update Tuesday on the Chevrolet Volt www.chevrolet.com/volt, during a development drive on the West Coast.
Burbank, Calif. – General Motors Co. is testing a production-intent hydrogen fuel cell system that can be packaged in the space of a traditional four-cylinder engine and be ready for commercial production in 2015.
Chevrolet, la marca líder del sector automotor, ha venido trabajando arduamente en la transformación de su portafolio de productos y servicios, para ofrecer a sus clientes lo mejor en diseño, tecnología, desempeño y seguridad. La marca dio el primer paso de su evolución, en 2016, con la renovación de su portafolio y ahora ofrece productos y servicios innovadores, que responden a las diversas necesidades de los clientes colombianos.


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Blacksmith Swage Block
Practical Blacksmithing and Metalworking
In an established permanent blacksmith's shop, the support is a ... A swage block is not essential for all blacksmithing, but it is convenient to have one when curves have to be made to exact sizes or many parts have to be made to match.
Machine blacksmithing
Swage blocks take the place of a large number of individual tools, particularly bottom swages and heading tools. There probably is a larger variety of -shapes and sizes of swage blocks than of any other blacksmith tool on the market. The style ...
By using a hack-saw, the crank can be put in shape for the lathe before it leaves the blacksmith Bhop. The stock intended for a crank should be wide enough for Plff. 6. Taper Cone for Forging Rings, Collars, etc. for Swage Blocks. Fig. 6.


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I doubt very much that the Strohs would trade Oswalt within the division. Rumor has it that the Rangers are in the hunt.
And while Harang has not been terrible, unless he turns it around somewhat up to the trading deadline, and we can get a team to bite, he's ours for the remainder of the season IMO.


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Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study
- Marian Suarez-Gestal1,
- Manuel Calaza1,
- Emöke Endreffy2,
- Rudolf Pullmann3,
- Josep Ordi-Ros4,
- Gian Domenico Sebastiani5,
- Sarka Ruzickova6,
- Maria Jose Santos7, 8,
- Chryssa Papasteriades9,
- Maurizio Marchini10,
- Fotini N Skopouli11,
- Ana Suarez12,
- Francisco J Blanco13,
- Sandra D'Alfonso14,
- Marc Bijl15,
- Patricia Carreira16,
- Torsten Witte17,
- Sergio Migliaresi18,
- Juan J Gomez-Reino1, 19,
- Antonio Gonzalez1Email author and
- the European Consortium of SLE DNA Collections
DOI: 10.1186/ar2698
© Suarez-Gestel et al.; licensee BioMed Central Ltd. 2009
Received: 24 March 2009
Accepted: 14 May 2009
Published: 14 May 2009
We aimed to replicate association of newly identified systemic lupus erythematosus (SLE) loci.
We selected the most associated SNP in 10 SLE loci. These 10 SNPs were analysed in 1,579 patients with SLE and 1,726 controls of European origin by single-base extension. Comparison of allele frequencies between cases and controls was done with the Mantel–Haenszel approach to account for heterogeneity between sample collections.
A previously controversial association with a SNP in the TYK2 gene was replicated (odds ratio (OR) = 0.79, P = 2.5 × 10-5), as well as association with the X chromosome MECP2 gene (OR = 1.26, P = 0.00085 in women), which had only been reported in a single study, and association with four other loci, 1q25.1 (OR = 0.81, P = 0.0001), PXK (OR = 1.19, P = 0.0038), BANK1 (OR = 0.83, P = 0.006) and KIAA1542 (OR = 0.84, P = 0.001), which have been identified in a genome-wide association study, but not found in any other study. All these replications showed the same disease-associated allele as originally reported. No association was found with the LY9 SNP, which had been reported in a single study.
Our results confirm nine SLE loci. For six of them, TYK2, MECP2, 1q25.1, PXK, BANK1 and KIAA1542, this replication is important. The other three loci, ITGAM, STAT4 and C8orf13-BLK, were already clearly confirmed. Our results also suggest that MECP2 association has no influence in the sex bias of SLE, contrary to what has been proposed. In addition, none of the other associations seems important in this respect.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease of wide variability in its manifestations and clinical evolution that characteristically involves multiple autoantibodies against ubiquitous nuclear antigens. Its genetic component is very significant, as shown by a sibling recurrence risk ratio of 20 and a 10-fold excess in SLE concordance between monozygotic twins over dizygotic twins [1, 2].
Newly systemic lupus erythematosus-associated loci that were examined with previous evidence of association
Sample size
Exon 3
1.78 (1.6 to 2.0)
European American
1.55 (1.2 to 2.0)
African American
2.07 (1.3 to 3.4)
Other SNPs
Intron 3
1.5 (1.2 to 1.8)
1.50 (1.4 to 1.7)
European American
1.55 (1.3 to 1.8)
European American
1.61 (1.4 to 1.9)
1.62 (1.2 to 2.2)
1.56 (1.4 to 1.7)
Other SNPs
1.39 (1.3 to 1.5)
European American
Other SNPs
Exon 8
0.625 (0.5 to 0.8)
Other SNPs
Intron 2
1.58 (1.3 to 1.9)
1.29 (1.1 to 1.5)
0.82 (0.8 to 0.9)
Intron 1
0.74 (0.6 to 0.9)
0.70 (0.5 to 0.9)
0.63 (0.5 to 0.8)
0.78 (0.6 to 0.9)
0.58 (0.4 to 0.8)
Intron 4
0.78 (0.7 to 0.9)
Intron 5
1.25 (1.2 to 1.4)
Exon 8
UK Caucasian
In the present paper, therefore, we have analysed SLE association to each of these loci in more than 1,500 SLE patients and 1,700 controls – and all of them except LY9 have been clearly replicated. In addition, we have found that many of these loci are also important for SLE in men where data from previous reports is almost completely absent.
Materials and methods
Sample collection
We used DNA samples from SLE patients and ethnically matched healthy controls of 16 collections from nine European countries (see Table S1 in Additional data file 1). Most of these samples have already been described [17]. Two new sample collections were from Asturias, Spain and Almada, Portugal. Each recruiting centre was asked for about 100 SLE patients and 100 ethnically matched controls. A total of 1,579 cases and 1,726 controls were obtained in this way. All SLE patients met the revised American College of Rheumatology classification criteria [18]. Clinical characteristics of the patients are provided in Table S2 in Additional data file 1. Patients and controls gave written informed consent. Sample collection was approved by the respective ethical committees.
We selected a SNP for each of the 10 associated loci that we intended to replicate (Table 1). The SNPs were selected because they were strongly associated with SLE or because they were described as probable causal polymorphisms. These 10 SNPs were amplified in a single PCR with the Qiagen Multiplex PCR kit (Qiagen, Chatsworth, CA, USA) with 20 ng genomic DNA and 0.2 μM of each primer (for primers and probes, see Table S3 in Additional data file 1). The PCR products were purified by digestion with Exonuclease I (Epicentre, Madison, WI, USA) and shrimp alkaline phosphatase (GE Healthcare, Barcelona, Spain). Purified PCR products were genotyped by single-base extension with the SNaPshot Multiplex Kit (Applied Biosystems, Foster City, CA, USA) and specific probes. After a second purification with shrimp alkaline phosphatase (GE Healthcare), samples were analysed in the Abi Prism 3130xl Genetic Analyzer (Applied Biosystems) and genotypes assigned by the GeneMapper software. All genotype calls were manually reviewed and conflicting results were liberally re-assayed or re-genotyped by sequencing with the Big Dye Ready Reaction Kit v 3.1 (Applied Biosystems). Sequence reactions followed the kit manufacturer protocol and were also analysed in the Abi Prism 3130xl Genetic Analyzer.
Statistical analysis
Some of the sample collections in our study have already been used for the analysis of specific associations included in this project. They have been excluded from the relevant analyses to avoid data duplication; this circumstance is detailed in Table S4 in Additional data file 1, where raw genotype data from each sample collection are reported. Hardy-Weinberg equilibrium tests in control samples were performed with Haploview with a threshold of 0.05 uncorrected for multiple tests [19]. Other statistical analyses were carried out in a customized version of the Statistica 7.0 program (StatSoft, Tulsa, OK, USA).
Comparison of cases and controls was carried out with the Mantel–Haenszel approach because allele frequency differences are probable between sample collections even if specific effects on the phenotype are constant. Spurious false positive or false negative results therefore become likely if the allele differences are not accounted for. To avoid this, the Mantel–Haenszel approach combines effect sizes taken as the odds ratio (OR) in each stratum allowing for heterogeneity in allele frequencies. This approach provides an accurate combined statistic if the heterogeneity of effect sizes, evaluated with the Breslow–Day test, is excluded. Significant heterogeneity of effects is therefore excluded by the Breslow–Day test and allele frequency heterogeneity is accounted for with the Mantel–Haenszel approach. These analyses were also conducted after stratifying the samples by gender. Univariate logistic regression models were used to test the fit to the data of additive, recessive and dominant genetic models. Statistical power was estimated with the Power and sample size calculations software [20].
Combined analysis of allele frequency differences between SLE cases and controls for nine autosomal loci
Minor allele frequency (%)a
Mantel – Haenszel analysis
Breslow – Day test
SNP (locus)
SLE cases
P value
P value
rs1143679 (ITGAM)
23.2 (730/3,152)
15.1 (521/3,448)
1.70 (1.5 to 1.9)
1.1 × 10-16
rs7574865 (STAT4)
32.8 (709/2,162)
23.2 (485/2,092)
1.62 (1.4 to 1.9)
2.4 × 10-12
rs13277113 (C8orf13-BLK)
30.9 (874/2,824)
25.7 (776/3,024)
1.34 (1.2 to 1.5)
5.1 × 10-7
rs2304256 (TYK2)
23.3 (733/3,152)
27.8 (960/3,450)
0.79 (0.7 to 0.9)
2.5 × 10-5
rs10798269 (1q25.1)
27.3 (861/3,158)
31.8 (1,098/3,452)
0.81 (0.7 to 0.9)
rs17266594 (BANK1)
24 (526/2,192)
27.6 (624/2,260)
0.83 (0.7 to 0.9)
rs4963128 (KIAA1542)
30.3 (955/3,150)
34.0 (1,173/3,448)
0.84 (0.8 to 0.9)
rs6445975 (PXK)
27.3 (772/2,824)
24.2 (734/3,034)
1.19 (1.1 to 1.3)
rs509749 (LY9)
43.1 (1,359/3,154)
43.8 (1,513/3,452)
0.97 (0.9 to 1.1)
The combined data showed significant differences between SLE cases and controls for eight of the nine SNPs located in autosomal chromosomes (Table 2). All of the significant differences between cases and controls were in the same direction as originally reported (Tables 1 and 2). We found association of the four SNPs that have been reported in a single GWA and not yet replicated by independent studies: rs10798269 in 1q25.1 (OR = 0.81, P = 0.00013), rs6445975 in PXK (OR = 1.19, P = 0.0038), rs17266594 in BANK1 (OR = 0.83, P = 0.0062) and rs4963128 in KIAA1542 (OR = 0.84, P = 0.0011). There was also significant association of two of the three SNPs that were described in large studies but that were not observed in any of the GWA studies: rs2304256 in TYK2 (OR = 0.79, P = 2.5 × 10-5) and rs17435 in MECP2 (analysis of this SNP was performed separately in women and men because this gene is in chromosome X; see below). Only rs509749 in LY9 was similar in cases and controls. Our study had sufficient power (80%) to detect association at this SNP with an effect size equivalent to OR > 1.15 with P < 0.05 (or OR > 1.23 for P < 0.001).
In addition to these important results for replication, we found association with the three loci that have already been replicated in GWA studies: rs1143679 in ITGAM (OR = 1.70, P = 1.1 × 10-16), rs7574865 in STAT4 (OR = 1.62, P = 2.4 × 10-12) and rs13277113 in C8orf13-BLK (OR = 1.34, P = 5.1 × 10-7). The effect sizes of these three association signals (that is, their ORs) were larger than for all the other signals, perhaps explaining the more consistent replication of their association. Genotype comparisons for the different SNPs were concordant with an additive genetic model and yielded very similar results to the allele frequency analyses (data not shown).
Combined analysis of allele frequency differences between SLE women and control women
Minor allele frequency (%)a
Mantel – Haenszel analysis
Breslow – Day test
SNP (locus)
SLE cases
P value
P value
rs1143679 (ITGAM)
22.3 (621/2,782)
15.1 (329/2,182)
1.67 (1.4 to 2.0)
2.0 × 10-11
rs7574865 (STAT4)
33.1 (636/1,920)
24.0 (317/1,322)
1.60 (1.4 to 1.9)
8.4 × 10-9
rs13277113 (C8orf13-BLK)
30.9 (777/2,514)
25.7 (475/1,848)
1.33 (1.2 to 1.5)
5.4 × 10-5
rs2304256 (TYK2)
22.9 (638/2,782)
27.2 (592/2,180)
0.81 (0.7 to 0.9)
rs17435 (MECP2)
26.7 (744/2,784)
22.8 (498/2,186)
1.26 (1.1 to 1.4)
rs10798269 (1q25.1)
27.1 (754/2,786)
32.3 (705/2,182)
0.77 (0.7 to 0.9)
6.2 × 10-5
rs17266594 (BANK1)
23.9 (464/1,938)
26.9 (386/1,436)
0.87 (0.7 to 1.0)
rs4963128 (KIAA1542)
30.4 (845/2,778)
33.9 (741/2,182)
0.85 (0.8 to 1.0)
rs6445975 (PXK)
26.7 (670/2,514)
23.5 (436/1,854)
1.22 (1.1 to 1.4)
rs509749 (LY9)
43.3 (1,206/2,784)
44.0 (962/2,184)
0.98 (0.9 to 1.1)
Comparison of SNP allele frequencies between SLE men and control men
Minor allele frequency (%)a
Mantel – Haenszel analysis
SNP (locus)
SLE cases
P value
rs1143679 (ITGAM)
27.9 (83/298)
15.7 (181/1,154)
2.08 (1.5 to 2.8)
1.2 × 10-6
rs7574865 (STAT4)
31.7 (64/202)
21.5 (159/740)
1.69 (1.2 to 2.4)
rs13277113 (C8orf13-BLK)
31.0 (88/284)
25.1 (267/1,064)
1.34 (1.0 to 1.8)
rs2304256 (TYK2)
26.8 (80/298)
28.8 (334/1,158)
0.91 (0.7 to 1.2)
rs17435 (MECP2)b
29.2 (42/144)
18.5 (105/568)
1.82 (1.2 to 2.8)
rs10798269 (1q25.1)
28.0 (84/300)
30.7 (355/1,158)
0.88 (0.7 to 1.2)
rs17266594 (BANK1)
26.2 (56/214)
28.4 (227/798)
0.89 (0.6 to 1.3)
rs4963128 (KIAA1542)
28.0 (84/300)
34.9 (403/1,156)
0.73 (0.6 to 1.0)
rs6445975 (PXK)
32.1 (86/268)
24.8 (265/1,068)
1.43 (1.1 to 1.9)
rs509749 (LY9)
40.6 (121/298)
42.9 (496/1,156)
0.91 (0.7 to 1.2)
Our aim has been to contribute to the definition of consistent SLE genetic factors derived from recent sound studies: four of the associations have been described in a GWA study, but not in a second GWA study or any other study; another two associations were identified in large studies, but not in any of the GWA studies; and one association is more controversial (Table 1). Our results are highly reassuring because all of the associations, except one from the group not found in any GWA study, were replicated with clarity and showed the same disease-associated allele as originally reported. This high degree of reproducibility is a fundamental change that large studies have brought to genetic research of SLE and other complex diseases [2, 21]. This change allows a bright future for the investigation of the genetic component of SLE.
The most remarkable result from the present study has probably been the association signal observed with the rs2304256 nonsynonymous SNP of TYK2 (OR = 0.79) because this has been a controversial SLE genetic factor. The rs2304256 SNP introduces a valine to phenylalanine change in the Janus homology domain 4 of TYK2 whose functional relevance has not yet been tested. This nonsynonymous SNP showed the strongest association among the 11 TYK2 SNPs studied in Scandinavian families [15], but was not associated in a study of UK families [16]. This latter study, however, found association with another TYK2 SNP (rs12720270) that was not associated in the Scandinavian study. Finally, the International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN) GWA study excluded association with the rs12720270 SNP (the rs2304256 SNP was not included in the GWA panels) [3]. Our results are important in this context because they show a significant association that confirms the role of the rs2304256 nonsynonymous SNP. In addition, combined analysis of all available data show a clear SLE association (P = 2.10 × 10-11) that is stronger than the required for genome-wide significance.
Tyk2 is a Janus-family tyrosine kinase that is bound to cytokine receptors and becomes activated after ligand binding. Deficiency of TYK2 leads to defects of multiple cytokine pathways, including type I interferon, IL-6, IL-10, IL-12, and IL-23, and to impaired T-helper type 1 differentiation and accelerated T-helper type 2 differentiation [22]. Only future research will indicate which of these pathways is critically affected by the TYK2 risk allele.
Following in importance is the association of MECP2 because our results provide replication and indicate that a previous assumption about the role of this genetic factor in contributing to the sex bias in SLE is questionable. Sawalha and colleagues considered the X-chromosome methyl CpG binding protein 2 coding gene (MECP2) as a possible SLE genetic factor based on two features: SLE predominance in women and abnormal regulation of methylation-sensitive T-cell genes in SLE [13]. MECP2 could be involved in both phenomena because this gene is in the X chromosome and participates in DNA methylation. Sawalha and colleagues found association with several SNPs in women from two ethnic groups, Korean and European (OR for rs17435 = 1.58 and 1.29, respectively) [13]. The association we have found in women (OR = 1.26) is very similar to that reported in their European sample, providing strong confirmatory evidence. This replication is important for the status of MECP2 due to the lack of association signals in the SLE GWA studies.
In addition, we have found that the MECP2 SNP is also associated with SLE in men (OR = 1.82, P = 0.0046), which was not previously known. This result seriously undermines the hypothesized role of MECP2 in SLE gender bias. In retrospect, lack of sex specificity is congruent with experiments that showed MECP2 is not expressed in the inactivated X chromosome of women [23], which implies expression levels in men and women should be equivalent. Future research should aim to establish whether any of the SLE-associated SNPs in MECP2 has a functional effect and to find evidence of the hypothesized relationship between altered methylation of T-cell genes in SLE and MECP2. In addition, it is even unclear whether the causal polymorphism affects MECP2 because SLE association has also been reported with genetic variants in a neighbour gene, IRAK1, which is a key mediator in the signalling pathways of Toll-like receptors/IL-1R [24].
The rs10798269 SNP in the 1q25.1 locus, the rs4963128 SNP in the KIAA1542 gene and the rs6445975 SNP in the PXK gene were reported in the SLEGEN GWA study [3] with P values below 2 × 10-7, but they were not reported in Hom and colleagues' GWA study [4] and none of them has yet been replicated in any other study. The three SNPs were associated with SLE in our study, with effect sizes that are similar to those reported (OR = 0.81 versus 0.82 for the 1q25.1 SNP, 0.84 versus 0.78 for the KIAA1542 SNP, and 1.19 versus 1.25 for the PXK SNP). None of these three SNPs has any predictable functional effect. In addition, the rs10798269 SNP in the 1q25.1 locus is far from any known transcript and the PXK and KIAA1542 genes are of unknown function. The KIAA1542 gene, however, is about 20 kb away from the IRF7 gene and in linkage disequilibrium with it, raising the possibility that this association could be related with IRF7 function [3]. Our replication of these associations increases the need for research aimed to the identification of their functional effects.
We have also found a significant association with the rs17266594 in the BANK1 gene. This SLE genetic factor has been identified in a low-resolution GWA study in a Swedish sample and replicated in other European sample collections in the same study [5], but it was not found in any of the high-resolution GWA studies and has not yet been replicated by other groups. Our results provide this independent replication, although with a more modest effect (OR = 0.83 in our study versus 0.70 in Kozyrev and colleagues [5]). The causal polymorphism can be the rs17266594 SNP itself, which seems to alter splicing efficiency of BANK1, or two BANK1 nonsynonymous SNPs of possible damaging effect. Linkage disequilibrium between these three SNPs has prevented dissection of their relationship to SLE susceptibility [5]. BANK1 codes for a B-cell scaffold protein with ankyrin repeats that is implicated in B-cell receptor-mediated signalling.
The rs509749 SNP of LY9 is the only SNP that was not replicated in our study. We selected this SNP because it seems to explain the 1q23 SLE-linked locus according to a large family-based study [14]. 1q23 is one of the most consistently described SLE loci in linkage studies (and its syntenic region in the mouse lupus models) [1]. Examination of SNPs all along this locus showed stronger association with the rs509749 SNP [14]. This SNP has a predictable impact in protein function and is associated with changes in the proportion of specific T-cell subsets [14]. All this evidence made the rs509749 SNP a good candidate for replication in our view, even if the level of significance of the SLE association was notably lower than the reported for the other nine SNPs studied here (P = 0.002). Lack of replication of this SNP in contrast with replication of the other nine SNPs provides support for the direct relationship between very low P values obtained in sound studies and the reproducibility of genetic association findings [21].
The most associated SNPs in our samples were the three that were already confirmed previous to our study. These three SNPs were associated with SLE in at least three large studies. The largest effect was observed with a nonsynonymous SNP in the third exon of the ITGAM gene (rs1143679, OR = 1.70) [3, 4, 6, 7]. This nonsynonymous SNP was the most associated in one of the previous studies (with very similar effect, OR = 1.74) [7], and has been hypothesized to disturb ITGAM interaction with its ligands, but still no functional evidence is available. Another clearly established association [3, 4, 6, 8–12] was the second strongest in our study: SNP rs7574865 in the third intron of the STAT4 gene (OR = 1.62). This association seems stronger in patients with a severe phenotype [12]; however, no functional polymorphism has been identified in this locus. The next strongest association (OR = 1.34) was with the rs13277113 SNP, which has been reported in the GWA study of Hom and colleagues [4], with a similar effect (OR = 1.39). This SNP is located between C8orf13 (of unknown function) and BLK (B-lymphoid tyrosine kinase), two genes that are transcribed in opposite directions. No functional variant has been identified in this locus, but the risk allele of this SNP correlates with low mRNA levels of BLK and high levels of C8orf13, raising the possibility that either of these two effects could be related with SLE. Graham and colleagues found association with a strongly linked SNP in the BLK gene [6], while the SLEGEN GWA study found association with an unlinked SNP in this locus, suggesting the possibility of two independent genetic factors [3].
In addition, we have found that most examined SLE-associated SNPs seem to be shared between women and men. Results are not definitive given the small number of men in the patient group. This lack of differential association is important because we do not know definitively the causes of the female preference of SLE. Lack of detailed gender analysis in previous genetic reports is regrettable because only aggregation of data from multiple studies will allow us to know whether genetic factors contribute to this sex bias.
In summary, our study has provided independent replication of nine SLE-associated loci, six of them of confirmatory importance because they have not yet been independently replicated by other groups (1q25.1, MECP2, KIAA1542, PXK and BANK1) or because their association was controversial (TYK2). These results bring the number of strongly confirmed associated loci to 13. Replication in independent studies is indispensable for considering a genetic factor in this category, although the common use of multiple case–control sets inside the same study or of large sample collections has increased the chances of replication [2]. Some other promising associations have been discovered [6, 25], or await sufficient independent replication [2], but it is already certain that the genetic component of SLE is especially rich in genetic factors with effects above the detectable level with current studies (OR = 1.15 to 1.25). We are therefore now in a phase of exciting discoveries in this field. There still remain formidable challenges, however, because it is necessary to transform the information we obtain into useful knowledge and, as has been discussed above, we have very few clues regarding the meaning of the identified SLE associations. Future studies should try to identify the causal variants and to determine their effect at molecular, cellular and disease levels, including the assessment of their role in the different SLE phenotypes and the probable similar effect in women and men.
Authors' information
Other contributors to the European Consortium of SLE DNA Collections: Attila Kovacs (Albert Szent-Györgyi Medical and Pharmaceutical Centre, University of Szeged, Hungary); Rudolf Pullmann Jr (Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA); Eva Balada (Hospital Vall d'Hebron, Barcelona, Spain); Ctibor Dostal (Institute of Rheumatology, Prague, Czech Republic); Filipe Vinagre (Hospital Garcia de Orta, Almada, Portugal and Instituto Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal); Iris Kappou-Rigatou (Evangelismos Hospital, Athens, Greece); Raffaella Scorza (University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy); Maria Mavromati (Athens University Medical School, Athens, Greece); Carmen Gutierrez (Hospital Universitario Central de Asturias, Universidad de Oviedo, Spain); Ignacio Rego (INIBIC-CH Universitario A Coruña, Spain); Nadia Barizzone (Eastern Piedmont University, Novara, Italy); Cees G Kallenberg (University Medical Center Groningen, The Netherlands); and Reinhold E Schmidt (Hannover Medical School, Hannover, Germany).
A report published in Arthritis & Rheumatism after publication of this manuscript provided further confirmation of the association of MECP2 with SLE [26].
B-cell scaffold protein with ankyrin repeats 1
B-lymphoid tyrosine kinase
genome-wide association
integrin alpha M
lymphocyte antigen 9
methyl CpG binding protein 2
odds ratio
PX domain containing serine/threonine kinase
systemic lupus erythematosus
International Consortium for Systemic Lupus Erythematosus Genetics
single nucleotide polymorphism
signal transducer and activator of transcription
tyrosine kinase 2.
The authors thank Carmen Pena-Pena for providing outstanding technical assistance. MS-G is the recipient of a FPU predoctoral bursary of the Spanish Ministry of Education. The present work was supported by Fondo de Investigacion Sanitaria of the Instituto de Salud Carlos III (Spain), grants 04/1651 and 06/0620 that are partially financed by the Fondo Europeo de Desarrollo Regional program of the European Union, by grants from the Xunta de Galicia, and by BMBF KN Rheuma grant C2.12 (to TW).
Authors' Affiliations
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I just saw this posted over at BetaNews
Whether it proves to be true I guess we will have to wait and see.
I really hope it is false and they continue to offer the product.
Actually if Microsoft withdraw it I will be disgusted.
I can still download it from the MS site at present.
Microsoft Private Folder 1.0
The main points I have seen raised are;
IT Administrators fear users will hide stuff from them and/or forget the password and lose access to files.
Parents are concerned the kids might hide stuff in them.
The so called IT Admins should know better. I suspect they are completely inept if they fear this program. C'mon, you control what gets installed on your network, don't you?
Parents, are you aware that your kids could and have been doing this forever. There are countless tools available to do it. Ever heard of zip files, yes, they can be password protected. There is no point listing them all, you can google them if you wish.
As to whether people forget their password and lose access. Big deal, you use it, you lose it, you are responsible. Why blame someone else or expect them to solve it. It is quite clear that this is what would happen.
I have been asked about this feature thousands of times over the last 10 years. Just try a google groups search and see how many posts on this topic are there. Obviously people want it. So let them have it.