text:
My husband built the teahouse, took him almost two years - he did the whole
thing himself (I provided a little manual labor). He started out with the
idea for a simple gazebo. Then he saw this picture in a magazine and figured
he could build it. Well, you get an engineer started on something like that
and requirements creep is practically inevitable. So now we have a sort-of
Japanese teahouse...with stained glass windows (it's a long story)...and a
sort-of Japanese garden to go with it. And it's pretty darn nice even if you
can't put misters out there, which was the original idea.
We can't ever sell, there's too much work invested here!
-----Original Message-----
From: firstname.lastname@example.com [mailto:email@example.com] On Behalf
Of Chris Petersen
Sent: Saturday, May 20, 2006 5:42 AM
To: firstname.lastname@example.com
Subject: RE: [CHAT] A lovely weekend
It was nice to look at your garden pictures. It's so different where you
live, being a high desert environment and all. Creating an oasis in all that
arid terrain must be satisfying. That's some vegetable garden! I'm lucky
to get a couple of tomatoes planted along with my favorite herbs. I liked
the nice combinations of plant material in your gardens. You have a tea
house? I'm impressed!
Chris Petersen
Northport, Long Island, New York
Zone 7a (Average min temp 50 - 00)
My garden: http://photos.yahoo.com/chrispnpt
To sign-off this list, send email to email@example.com with the
message text UNSUBSCRIBE GARDENCHAT
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE GARDENCHAT


text:
I guess it depends on your clients... I would want one that was just about
ready (over the hump to speak), but not in bloom.
At previous native plant sales, we would force natures hand and have one of
each thing blooming (well try to, didn't always work). Dang nabbit, someone
would buy that plant first, even after explaining that it is the wrong time
and you should pick another one.... but they just tug onto that plant...
What do the rest of you do?
> Donna,
> Sorry , to put you to the trouble, but those were times for summer bulbs,
> not spring bulbs. Last night I did look through my files and found
> estimates of 2 to 3 weeks and 2 to 4 weeks, with a caveat. The caveat was
> that tulips require adequate rooting (noted by roots coming out the
> bottom)
> regardless of whether shoots are coming out the top, for them to be ready
> to
> be moved. So I'll check the bottoms tomorrow. I bet they are ready
> because
> they've had at least 16 weeks out there. I'll probably bring them in at
> the
> end of March for the April 15 sale. I want them to be in bud, but not in
> flower, so buyers will feel they'll get their money's worth, timewise. A
> tag with the name and a picture will be attached to each pot. Or do you
> think I should have some in bloom to draw attention?
> BTW - I'm sending this to Chat too in case anyone is interested in the
> timing and in case others have ideas about whether they should be in bloom
> or in bud for the sale.
> Kitty
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message text UNSUBSCRIBE GARDENCHAT

subset: commoncrawl


text:
I am due to have an operation on my ankle in June. Are there any natural remedies that might help my recovery after surgery?
Ken Graham
The body's healing mechanism is, to a degree, dependent on nutrients. One of the most important healing nutrients is vitamin C, which promotes the regeneration of soft tissues. Take 1,000mg, twice a day. Other vital nutrients include zinc, vitamin B12 and folic acid, which stimulate cell formation. Take 30mg of zinc plus 500-1,000mcg of vitamin B12 and folic acid each day. To this regime, add Centella asiatica (Gotu kola). This herb reduces healing time and improves the strength of healing tissue. Take 500mg, twice a day. I suggest you take these supplements for two months, starting a month before surgery. Also, for two days before and until 10 days after surgery, take a supplement of bromelain (an extract of pineapple). It seems to lessen swelling and inflammation, and may reduce healing time by helping to clear tissue debris at the site of surgery. Take three capsules of bromelain, three times a day, on an empty stomach.
· If you have any issues you would like Dr Briffa to address in his column, please email him on firstname.lastname@example.com. Please note that Dr Briffa cannot enter into any correspondence.
You can also visit www.drbriffa.com. Before following any recommendations in this column, you should consult your own medical adviser about any medical problems or special health conditions
Thanks to guardian.co.uk who have provided this article. View the original here.


text:
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PAID VALUE EXPIRES ON February 26, 2022
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text:
A dual axis rotational angiography where C-arm rotates in curved trajectories around the patient, allowing imaging in all desired anatomical views in a single run. Reduce contrast dose, reduce radiation exposures.
Dual axis rotation
Multiple scans reduced to one run
Improved diagnostic confidence
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Biplane cardiovascular X-ray system enhances complex procedures
Making the difference with Live Image Guidance
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See with confidence - every time
SkyFlow provides contrast equivalent to the images acquired with a grid
CT TrueView creates a 3D reconstruction...
Immediate visualization of stent in coronary arteries
Superb insight with 3D cardiac imaging
By clicking on the link, you will be leaving the official Royal Philips Healthcare ("Philips") website. Any links to third-party websites that may appear on this site are provided only for your convenience and in no way represent any affiliation or endorsement of the information provided on those linked websites. Philips makes no representations or warranties of any kind with regard to any third-party websites or the information contained therein.


text:
In a message dated 12/31/2002 5:18:46 AM Eastern Standard Time,
email@example.com writes:
> yeah. if anything it has more uses than either duct tape or wd-40. our
> house is florida concrete block, so when the short one wanted tile house
> numbers that's how we stuck them up.
> At 08:16 PM 12/30/02 -0600, you wrote:
> >Well... interesting- It now has a million and one uses :) Almost as good
> >as duct tape, both of which can always be found in my house somewhere...
> >
Sounds as if I will have to amend my mantra:
You only really need two tools. WD-40 and duct tape. If it doesn't move and
it should, use WD-40. If it moves and shouldn't, use the tape.
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text:
Aquarium and Ponds UK
garden maintenance, Pond Supplies, Pond maintenance
Regular pond maintenance is an important part of maintaining a great looking pond and ensuring the best water quality for your fish to live in. In return the fish maintain better health and have a clean and safe environment to swim in. Pond plants will also thrive and grow well in a well maintained pond with good water quality.
We can offer regular maintenance for your pond on a
Monthly, Quarterly or Annual basis,
whichever suits your ponds needs.
We will make sure your pond looks wonderful all year round.
These are just some of the maintenance services we provide:
Water Change (About 25%)
Vacuum where necessary
Filtration Cleaning
Servicing of Pumps
Service of UVC's and Bulb Changes
Plant Care
Water Quality and Testing
Fish Health
Print this page
We offer Aquarium maintenance throughout Kent, Surrey fand West Sussex for all tank sizes no matter how big or small. From 50L to 2000L all maintenance is undertaken.
As well as maintaining your Aquarium to make sure it stays in the best condition possible, having your tank cleaned is the second vital task needed to be done.
A pond doesn't have to be on a great scale to keep fish; as long as the fish and plants have room to grow they will be happy.
Pond cleaning is not done on a regular basis like the maintenance, but will help play a vital part in the up keep of your pond.
Pond Leaks & Repairs What do you need to do? Nothing!
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
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text:
Get the jump start on your Hangout weekend at our annual Thursday Kickoff Party.
Tickets for the Thursday, May 18th, Kickoff Party are $50 in advance. Discounted tickets available to 3-day General Admission ticket holders for a limited time.
The Thursday Kickoff Party is included with VIP and Super VIP tickets.
Lineup to be announced soon.
If payment is DEFAULTED, an automated email will be sent to the purchaser's email address and a 10-day grace period offered to update payment information and submit payment. If defaulted payment is not received, the order will be cancelled and a $50 cancellation fee will be charged.
For full Payment Plan Terms and Conditions click here.
To add HangoutFest on Snapchat, take a photo or screenshot of our Snapcode with your phone, open Snapchat, then tap at the top of the camera screen.


text:
Picking the Right Affiliate Marketing Software
When working with affiliate marketing, you need to be able to understand and pick the right software to fit your needs. There are tons out there (believe me, I've started looking and informing myself already) but sometimes it's just overwhelming. You can't really rely on word of mouth for these things, or reviews, because each one will fit you differently. Only you can decide what is right for you.
I came across this inforgaphic (that is extremely large and in charge) and decided this might be useful to share, since it's helped me a lot in understanding what each affiliate marketing software offers. Hope this helps!


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Sony MDR-7506 Review
Once more unto the budget bin, dear hobbyists—these Sonys are worth it.
Buy now at Amazon
- The Sony MDR-7506 is better than 34% of the headphones we tested.
- It is better than 39% of the headphones we have tested under $200.
- It is better than 37% of the over-ear headphones we have tested.
|Where to Buy
|Click for price Buy
Everyone wants comfortable design and great sound. Finding a decent solution for your home or office can be tricky, though, especially if you're looking to pay less than $100 bucks. Fortunately, Sony offers just that in the MDR-7506 (MSRP $130) headphones. In fact, we looked online and easily found these cans for just $77.
So what's the downside? The MDR-7056 have to stay in one place. Due to a very long cable and questionable materials, portability is a problem. And unless you enjoy equalizing your own tunes, the flat response may leave you longing for more in terms of sound quality. Yet hobbyists are sure to love this affordable option. For all-day listening, the Sony MDR-7506 offers a lot in exchange for a little.
Form & Features
These cans are made for listening—not looking.
Saving money feels great, but it seldom gets you a truly well-made product. The MDR-7506 is no exception. Sale prices of around $77 buy you solid sound and a great-feeling fit—you can listen to these over-ears comfortably for hours—but the design scheme is truly drab. The closer you look, the more devils you'll find in the details: a cable you can't remove; speaker pads that lack the durability to last; low-grade plastic as far as the eye can see. Handle with care.
We do appreciate the nearly 10-inch-long cord, though, which is great for the office. There is no remote of course—commuting with these won't be comfortable—but if you do need to take the MDR-7506s on the go, be sure to use the ugly little carry bag. Sony also includes a 1/4-inch adaptor to pair with the 1/8-inch basic one, a perk DJs and hobbyists will get plenty of use out of.
Audio Quality
Ready, set, equalize
Plenty of everyday listeners will like the MDR-7506's balanced sound quality right off the bat, but some will find it lacking. That's because the soundscape is very flat, meaning bass isn't as loud as what you'd normally find on mainstream headphones in this price range.
This is also precisely why many hobbyists will love the MDR-7506s; "flat" sound that doesn't over or underemphasize various portions of the musical range makes it easier to use an equalizer to tailor music to your own liking. Many listeners never use equalizers to customize their own sound, but the ones that do will appreciate these headphones—especially given the friendly asking price.
Even better, these headphones are very balanced in loudness between left and right speakers. Small imbalances are there, but the errors are so mild you'll never notice them. Distortion doesn't crash the party, either. While not completely free of unwanted pollution, the MDR-7506 has very, very low measures—many listeners will never even notice it.
Comparable Products
Before you buy the Sony MDR-7506, take a look at these other headphones.
Last Word
Take care of them, and they'll take care of you.
Sony's MDR-7506 (MSRP $130) may not dazzle you with its outfit—there is absolutely nothing exciting to look at here, and you'll probably need to replace the cheap ear pads at some point. Yet, like Don Quixote with his bowl for a helmet, there's still great quality within.
The sound is nicely balanced, so that no portion of the musical scale is too loud or too soft. Aspiring audiophiles will especially love this soundscape, because it's optimal for equalizing and mixing, which typically costs a lot more.
In terms of value, this is the best buy I've seen all year. A simple online search puts these over-ears in the neighborhood of $77. The Sony MDR-7506 isn't a convenient travel companion, and it doesn't win best-dressed, but it offers balanced sound with very little distortion in a comfortable, affordable package.
Our editors review and recommend products to help you buy the stuff you need. If you make a purchase by clicking one of our links, we may earn a small share of the revenue. Our picks and opinions are independent from any business incentives.


text:
Cowon Earphone Eh2
Sound fantastic woofer and tweeter, the finest hybrid earphone
Cowon EK2
" Not expecting much love here, because this product wasnt even listed, I thought its worth a brief comparison with the all so mighty piston. just a casual review. Cowon EK2 review, compared to Xioami Piston:- No, no formalities what so ever, No intros nothing, you are not here for intros And Add S to hits. Just to add that my piston has its filter and foam..." --suman134
Cowon EM1 In-Earphone
"These in ears are as cheap as it gets and you get what you pay for. Though when compared to similarly priced in ears a few things stand out. Build quality and looks are good. It comes with flat, relatively tangle free cord. Also its fairly resistant to micro phonics. It comes with 3 rubber tips, and I could not get perfect seal with any of them. I could hear faint noises. So its decent..." --vaibhavp
Diddybeats Designer In-Ear Headphones (Pink)
From music and fashion mogul, Diddy, comes a headphone like no other. Engineered to deliver all the power and energy of hip-hop and R&B, and designed to perfectly complement any high fashion wardrobe, Diddybeats perform at the highest levels, and look stunning doing it. Also features Monster ControlTalk for iPhone and iPod playback control and iPhone/music phone hands-free calling.
Lady Gaga HeartBeats In-Ear Headphones with ControlTalk
Sound is Fashion Heartbeats by Lady Gaga are holistically designed to deliver the soundtrack of your life with clarity and power, as well as satisfy your passion for fashion. Immerse yourself in pitch-perfect highs, precise mids, and club caliber bass. Because when your music sounds amazing, you stop hearing it, and start feeling it. In other words, sound really matters. Plus, Lady Gaga didn...
Monster® DNA In-Ear Headphones with ControlTalk™ for Apple - Black
"The Monster DNA in ear earphones are part of Monster Cable's effort to further distance themselves from the failed Beats By Dre experiment that supposedly took the headphone market by storm some time ago. Have they succeeded in their goal, or have they took a huge step back? Let's find out: So, a lot of people know that monster cable is an electronic giant, mostly known for their..." --zach8278
Monster Harajuku Lovers Space Age In-Ear Headphones
Create, express and work your style by customizing the ultra modern and out-of-this-world-cute Monster® - Harajuku Lovers Space Age G Headphones. Bring style and color all around the world (and beyond) with five interchangeable body colors. Mix and match them to create your own Space Age G style. Think of it as an ""earring"" that lets you go beyond just hearing music.
Monster Harajuku Lovers Super Kawaii In-Ear Headphones
So this is what super cute sounds like. Monster® - Harajuku Lovers Super Kawaii Headphones. High definition fine tuned sound no matter where you are around the world. From the streets of Harajuku and back again.
Monster Harajuku Lovers Wicked Style In-Ear Headphones
Harajuku Girls You Got the Wicked Style. Find your own wicked style. You can customize your Monster® - Harajuku Lovers Wicked Style Headphones with G and the four Harajuku Girls -- Love, Angel, Music, and Baby. Think of it as a costume change for your ears.


text:
The Fagan Center for Audiology is an Audiology practice that works with the Fagan Center for Communication to serve people of all ages with a variety of communication and hearing disorders.
For over 40 years the Fagan Center for Audiology has been helping people improve the quality of their lives in Portland and surrounding areas. Our Audiologists have a reputation for always having the latest digital hearing aids on the market today. We provide excellent service to our patients by diagnosing your hearing problem with hearing testing so we are able to provide you with the best hearing solution. If a hearing aid is needed, we will evaluate your hearing loss and lifestyle so we can provide you with the best hearing technology to suit your needs.
Contact our hearing professionals today to begin.
There's a hearing solution that's right for you.
Hearing aids that function in sync with your smartphone are among the most convenient technology available — but no hearing system operates as an extension of your devices the way the Made for iPhone® Hearing Aids do.
Our discreet invisible-in-the-canal hearing aid offers a secure fit and advanced noise-processing technology, making it ideal for life on the go.
Sleek and subtle, this completely-in-the-canal technology is molded to the contours of your ear for a superior fit that offers a natural look and hearing experience.
Our behind-the-ear technology puts you in control with customizable fit options, wireless connectivity, and easy volume control.
Reliable and convenient, the receiver-in-the-canal device has a lightweight feel and a flexible fit, and it is among our most popular systems.
With a discreet, glasses-friendly fit and external controls, our in-the-canal technology is the perfect piece to complement to your lifestyle.
Our in-the-ear hearing aids are custom molded for you and are powerful and comfortable, allowing for all-day use.
Beat the annoying, constant buzzing and ringing of tinnitus, and reestablish a sense of normalcy in your life with the AGX® tinnitus solution.
See what people are saying about Fagan Center for Audiology
"I want to thank Dr. Fagan for helping me deal with my hearing loss and tinnitus. The past several weeks have been a blessed relief and I am glad I didn't stop looking for someone who could help me."
I have been suffering from profoundly disturbing noises in my head (tinnitus) for 15 years. I was told by other professionals that nothing could be done to help me. My situation changed when I was referred to Dr. Fagan. He was able to reduce my tinnitus annoyance and give me a chance at a better life.
I have been a patient of Dr. Fagans for nearly ten years and have always found he and his staff to be highly caring, accommodating and professional. It continues to be a pleasure working with them. I recently purchased Audigy AGX hearing aids and find them to absolutely amazing. I am hearing significantly better now in all settings than at any time since I began wearing hearing aids.
I work as a tax preparer and before receiving my hearing aids at the Fagan Center for Audiology, I was unable to hear some of my clients. Now I am able to hear all of my clients and it has made my job easier and more enjoyable.


text:
WP Plugin Editing ( SMS Api Plugin ) Editing in gateway api
This project received 13 bids from talented freelancers with an average bid price of $947 USD.Get free quotes for a project like this
Project Budget$250 - $750 USD
Total Bids13
Project Description
i have worpdress Plugin attached with my blog for Send SMS to Member for Post updates i need multiple gateway for fire SMS to Different country wise member. Current my plugin support only 1 API for fire SMS.\r\nI need someone to edit it privately and Make ability to use API as per country code. \r\nhighly skilled programmer needed for edit in secure blog.
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- Forbes
- The New York Times
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- Wall Street Journal
- Times Online


text:
Definitions for a-sea
This page provides all possible meanings and translations of the word a-sea
Webster Dictionary
on the sea; at sea; toward the sea
Origin: [Pref. a- + sea.]
Chaldean Numerology
The numerical value of a-sea in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of a-sea in Pythagorean Numerology is: 8
Sample Sentences & Example Usage
Port Executive Director Jim Knight:
Sea lions 1, Astoria 0.
A river cannot boast to a sea.
Bolivia Pope Francis on Wednesday:
On the sea, dialogue is indispensable.
Where there is a sea there are pirates.
I'm not going near the sea for some time.
Images & Illustrations of a-sea
Find a translation for the a-sea definition in other languages:
Select another language:
Discuss these a-sea definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"a-sea." Definitions.net. STANDS4 LLC, 2017. Web. 21 Feb. 2017. <http://www.definitions.net/definition/a-sea>.


text:
The Easton is a stylish 4 bedroom 2.5 storey townhouse with plenty of flexible space for growing families.
The ground floor features a large living/dining room, while the kitchen/breakfast room is ideal for informal mealtimes. There is also a handy guest cloakroom and store cuopboard off the entrance hallway.
The first floor landing leads to two double bedrooms, a main bathroom and a further bedroom which could alternatively be used as a dedicated work space or play room.
Meanwhile, on the top floor there is a spacious master bedroom with en suite shower room and convenient dressing area.


text:
----- Original Message -----
orders at
To: firstname.lastname@example.com
Sent: Wednesday, April 04, 2007 3:32
Subject: [iris-photos] Gilt edge
Been working on this for a while but it has hard
to figure out how to develop it. Gilded edges on the standards don't
seem to be dominate, will keep working for more. So far this is the best
one I have. Anybody have any ideas on developing gilt
Mike Sutton
seedling s-454-p: (Twice Told x J-214:
(Connie Sue)) X Ghio 983F
7 buds
10 Greatest Ever
Share and vote
on Bix.com!
Sports News
Get up to the
minute sports news
Play the Intern Game
Win and work for
the next Apprentice.


text:
Wrapped in Courage
November 25th is the International Day for the Elimination of Violence Against Women, and you can pledge your support to be part of the solution to end the violence NOW. Purchase one of our fabulous purple, infinity scarves for $15, and 100% of the proceeds will support the work done by WNSS! Want to go a step further? Help spread the word and show your support by using the hashtag #WrappedInCourage, and tweet at @WrappdinCourage. Our scarves are selling fast, so reserve yours now! Email firstname.lastname@example.com to arrange for pick-up.


text:
http://sutherlandinstitute.org/wp-content/uploads/2015/03/logo_white_red_225x64.png 0 0 Pamela Whitmore http://sutherlandinstitute.org/wp-content/uploads/2015/03/logo_white_red_225x64.png Pamela Whitmore2014-03-18 11:13:472015-03-15 19:19:33What time is it? Caucus time!
What time is it? Caucus time!
Party caucuses are tonight and Thursday, so here's your chance to have a voice in Utah's political process! Click here for a giant infographic explaining how Utah's caucus system works. Click here to learn what delegates are and how they're important. And click here to find out how to become a delegate!


text: OverviewBack to top Schiff - Glucosamine Plus MSM - 60 Tablets Item# :54832UPC# :020525110299 Brand:Schiff Size/Form:60 Tablets Servings:20 Dosage:3 Tablet(s) This formula combines Glucosamine with MSM (methylsulfonylmethane), a naturally occurring organic source of organic sulfur. Glucosamine helps provide the building blocks for healthy cartilage and maintain structural integrity of joints and connective tissue.** Glucosamine is a building block for joint fluid, cartilage, tendons, ligaments, membranes and blood vessels.**


text:
Created attachment 400976 [details] [diff] [review]
When debugging the repaints in bug 424715, I noticed that drawRect is asked to repaint the whole view, even though we only call setNeedsDisplayInRect for much smaller rects. And not only that: the repainted rect was even larger than the view, expanded by 3 pixels to the top and to the bottom.
Then I remembered a paragraph from http://developer.apple.com/mac/library/releasenotes/Cocoa/AppKitOlderNotes.html#X10_5Notes :
> To help guarantee correct redraw of focus rings, AppKit may automatically draw
> additional parts of a window beyond those that application code marked as
> needing display. It may do this for the first responder view in the
> application's key window, if that first responder view's focusRingType property
> is set to a value other than NSFocusRingTypeNone. Any view that can become
> first responder, but doesn't draw a focus ring, should have its focusRingType
> set to NSFocusRingTypeNone to avoid unnecessary additional redraw.
So I added [self setFocusRingType:NSFocusRingTypeNone] to ChildView's init method, but it didn't make any difference.
Playing around some more, I discovered that the additional redraws only started after I had clicked the "Basic Render" button, i.e. only after we rendered a button with a focus ring.
The rest was easy.
When we draw a button with a focus ring, we first call setShowsFirstResponder:YES on the NSButtonCell, and then pass the NSView that contains our button frame to [button drawWithFrame:inView:]. This seems to mark our NSView permanently.
We can avoid that by simply using a pseudo view instead of the real view - whether the used view actually contains our button doesn't matter, as the investigation in bug 465069 has shown.
So that's what my patch does. I'm also adding setFocusRingType: NSFocusRingTypeNone (even though I couldn't see a difference) because Webkit does it, too.
Comment on attachment 400976 [details] [diff] [review]
Looks good but please file a bug with Apple about NSFocusRingTypeNone not stopping the invalidations and record the Apple bug number here.
this is potential perf worth blocking on, blocking1.9.2+
This is a regression from bug 450800.
Filed rdar://problem/7229728
Comment on attachment 400976 [details] [diff] [review]
I think we can also take this on 1.9.1 - it's a regression from 1.9.0 and the fix is reasonably safe. I looked into writing a test for this, but I'm afraid doing so seems impossible without bug 510970.
Comment on attachment 400976 [details] [diff] [review]
Approved for 220.127.116.11, a=dveditz for release-drivers


text:
Virus Watch is a new weekly video series that explores the amazing world of viruses. This week: the latest research on Zika virus, including finding virus in Brazilian monkeys, dengue antibodies helping Zika virus infection, and brain organoids to study how Zika virus causes microcephaly. Read More
I teach Microbiology at the University of Puget Sound every fall semester. The swiftly changing field of microbiology has depth and breath...and I was interested to learn what my students thought of the topic at the beginning of the first day of class. We will revisit this subject at the end o... Read More
Lung ultrasound has been shown to be highly effective and safe for diagnosing pneumonia in children and a potential substitute for chest X-ray, according to a study conducted at the Icahn School of Medicine at Mount Sinai. Results are currently published in the medical journal Chest. Read More
A central pursuit of microbial ecology is to accurately model changes in microbial community composition in response to environmental factors. This goal requires a thorough understanding of the drivers of variability in microbial populations. However, most microbial ecology studies focus on the ... Read More
Microbiologists attending Microbe 2016, the annual meeting of the American Society for Microbiology, attempt to explain their science in 30 seconds.
This video was produced during the Lights! Camera! Science! professional development workshop with the help of the attendees.
The music Ask R... Read More
Marine plastic debris is a growing concern that has captured the general public's attention. While the negative impacts of plastic debris on oceanic macrobiota, including mammals and birds, are well documented, little is known about its influence on smaller marine residents, including microbes t... Read More
Microbial communities are essential drivers of soil functional processes such as nitrification and heterotrophic respiration. Although there is initial evidence revealing the importance of soil type in shaping microbial communities, there has been no in-depth, comprehensive survey to robustly es... Read More
My undergraduate student Ruth Isenberg has made real progress adapting a GoPro camera to help us watch microbial interactions. Here are two swimming foci of Photobacterium leignothi encountering one another! Read More
Vaccines are like pathogen imposters - they mimic these 'bad guys' in order to provoke a response from our immune systems, remove the invader and begin the healing process.
One of the key components in a vaccine is an adjuvant, which serves to enhance our body's immune response to vaccination... Read More
When I have to explain the organism classification to my students I usually use the one stablished by Woese in the 70s. In this classification, all living things are classified in six kingdoms, that are Eubacteria, Archeobacteria, Protista, Plantae, Fungi and Animalia. All of these groups evolve... Read More
Biologists are beginning to understand how the trillions of microbes in and on our bodies shape our health. But differences between any two people's microbial populations are enormous. Most people share around 99 percent of their DNA with the person next to them, but they have a significantly sm... Read More
There is a growing popular and policy interest in the microbiome, and the possibilities of more nuanced or 'probiotic' ways of living with germs. To date however there has been limited public engagement with the science and technology of metagenomics. The project engages with the growing scienti... Read More
The last time you had a stomach bug, you probably didn't feel much like eating. This loss of appetite is part of your body's normal response to an illness but is not well understood. Sometimes eating less during illness promotes a faster recovery, but other times—such as when cancer patients exp... Read More
In this episode of Virus Watch, I explain how mosquitoes spread viruses. We'll look at how a mosquito finds a host, how it finds a blood vessel, and how it delivers viruses to a new host. Don't blame mosquitoes for viral diseases: it's not their fault!
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WASHINGTON — The Senate on Tuesday blocked a $1.1 billion bill to combat the Zika virus, giving Congress just two weeks to try to reach a new deal before lawmakers leave for a seven-week recess in the midst of mosquito season and a growing public health crisis. Read More
H.P. Lovecraft fan and composer Reber Clark (https://reberclark.bandcamp.com/) collaborated with my undergraduate student Ruth Isenberg and myself on a science+music+HPL video. When a log phase culture of Photobacterium leignothi is poured into a Petri dish, and 10 second exposures are taken ev... Read More
Today was the last day of my microbiology course at the University of Puget Sound. So I thought it appropriate for students to tell me the single "coolest" thing they learned in my course. Read More
The BBSRC and NERC-funded ShellEye project seeks to help shellfish farmers manage threats from harmful algal blooms and E. coli bacteria. The multi-partner ShellEye project brings together industry, government and scientists and aims to develop a satellite-based forecasting system to help fisher... Read More
Vincent Racaniello of the This Week in Virology podcast interviews Neal Nathanson, MD, about his career and professional experience in the field of virology. Nathanson's work has focused on the epidemiology and eradication of poliomyelitis, the control of the HIV/AIDS pandemic and the developmen... Read More
They're on your tongue, under your armpits, in your guts and on your skin. In fact, any place you can think of there are microbes living on, under, or in between there. In their unimaginably large numbers, these micro-organisms determine our lives – even though we never see them. Micropia, the w... Read More


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Subway's $5 footlong program has proved perennially popular, but the sandwiches still cost five times as much as the dollar-menu items at many quickservice rivals, spurring the addition recently of a $2 sandwich promotion. Wendy's has also found a way to fight back in the low-priced category, with new W burgers priced just under $3.
Full Story:QSRMagazine.com


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Zeneca and Lloyds Abbey Life offered contrary supporters an opportunity to display their courage as most shares slipped and slithered with many investors opting to snatch profits after this month's strong run.
In occasionally brisk trading the drugs giant, for so long one of the market's main takeover plays, climbed to a closing peak, up 20.5p (after 27.5p) to 1,538p.
This week's profit presentation by Roche, the Swiss group, prompted the gain. The company is cash-rich and anxious to expand; it wants to recapture its position as Switzerland's top drugs group.
The Swiss have, over the years, established a reputation for anticipating takeover activity. Rowntree Mackintosh, the sweets group, and Consolidated Goldfields are two prime examples of Swiss buying signalling corporate action. Last year's offer for Rothmans International, the cigarette group, was said to have been preceded by Swiss interest.
The Swiss, according to many observers, were mainly responsible for yesterday's Zeneca action. "They - and we - expect a bid; its a question of timing," said one dealer.
Zeneca is valued at around pounds 14.3bn. It no doubt feels it is too big to fall to a hostile strike. And in recent months it has underlined its reluctance to go along with bid stories.
It could be argued that despite their glamour rating its shares are merely reflecting growth prospects and the stream of new drugs likely to appear in the next few years.
Lloyds Abbey Life, the insurance group, ignored the scorn poured on the rumour of a Prudential Corporation strike which lifted its shares 32p on Wednesday. They improved a further 12.5p to 605p on suggestions Lloyds TSB, with 62.5 per cent of the capital, is about to emerge as the bidder.
Such an offer, said to be 675p a share, would make much more sense than the rumoured Pru attack. After selling its Mercantile & General reinsurance arm the Pru has cash to spare but Lloyds TSB, with the bolt-on advantages LAL offers, is an unlikely seller. The rest of the market, after its recent spectacular run, was in ragged retreat, largely unsettled by a New York plunge on higher interest rate fears.
The FT-SE 100 index fell 33.7 points to 3,885 and even the seemingly remorseless progress of the supporting FT-SE 250 index was halted. After a 20-day winning streak it suffered a 5.7 points setback to 4,432.1.
Asda, the superstores chain, fell 2.75p to 110.5p, lowest since May, as the market fretted about Archie Norman's decision to reduce his involvement. He has been the inspiration behind the group's revival. When he arrived four years ago the shares were bumping along at around 23p.
Allders, the department store group, added 6p to 214.5p awaiting a share buyback or special dividend and Yorkshire Electricity enjoyed a late run, gaining 15.5p to 777p on rumours a buy-back was planned.
General Electric Co remained unsettled by the George Simpson debate and Salomon Brothers caution; the shares fell 4.5p to 380.5p.
Courtaulds, the chemical group, was ruffled by losses suffered by its Austrian rival, Lenzings, falling 8.5p to 436.6p.
Ladbroke's better-than-expected figures and marketing deal with Hilton Hotels Corporation lifted the price 3.5p to 209.5p but Rolls-Royce, down 5.5p to 225.5p. and T&N, 8.5p easier at 135p, lost ground after results.
EMI, the showbiz group, spun 38.5p lower to 1,447.5p on forecasts of a CD and cassettes slowdown. Tring International, the compact disco group, underlined industry worries with a profits warning that left the shares down 6p at 18.5p. A year ago they were 118p.
British Aerospace broke through the 1,000p barrier with a 13.5p gain to 1,008.5p and expectations of a cheerful trading statement soon lifted Airtours 12.5p to 598.5p.
An attempt by Lord Cairns, chairman of BAT Industries, to rally the shareholder troops after the US tobacco litigation setback had no immediate impact with the shares falling 8.5p to 438.5p.
Greene King, the East Anglian brewer which recently splashed out pounds 297.5m for The Magic Pub Co, frothed up 6p to 625p as a buyer shopped for a million shares.
With its enlarged pubs estate Greene King is seen, in some quarters, as better value than some of the pure pub companies.
Ex-Lands, the property group, has been a disappointing investment. The shares were more than 50p at the start of the 1990's.
Even the demerger of its golf interests have failed to spark interest and the price has drifted steadily lower, reaching 7.5p.
Yesterday the shares perked up on suggestions the group could be involved in bid talks. In busy trading they put on 1p to 8.5p with Raglan Properties one of those named as a possible suitor.
Waverley Mining fell to a 12-month low of 69.5p. The shares were 116p at the start of the year.
There is persistent small selling with cheerful overseas developments overshadowed by nagging worries about its Scottish coal interests.
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I have some questions that I know this group has so much more experience
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The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis
© The Author(s) 2010
Received: 25 February 2010
Accepted: 24 June 2010
Published: 24 June 2010
Arginine is an amino acid that serves as a substrate for the enzymes nitric oxide synthase (NOS) and arginase, leading to synthesis of NO and ornithine, respectively. As such, arginine has the potential to influence diverse fundamental processes in the lung.
We used mice deficient in cationic amino acid transporter (CAT) 2 in models of allergic airway inflammation and pulmonary fibrosis.
We report that the arginine transport protein CAT2 was over-expressed in the lung during the induction of allergic airway inflammation. Furthermore, CAT2 mRNA was strongly induced by transgenically over-expressed IL-4, and allergen-induced expression was dependent upon signal-transducer-and-activator-of-transcription (STAT) 6. In situ mRNA hybridization demonstrated marked staining of CAT2, predominantly in scattered mononuclear cells. Analysis of allergic airway inflammation and bleomycin-induced inflammation in CAT2-deficient mice revealed that while inflammation was independent of CAT2 expression, bleomycin-induced fibrosis was dependent upon CAT2. Mechanistic analysis revealed that arginase activity in macrophages was partly dependent on CAT2.
Taken together, these results identify CAT2 as a regulator of fibrotic responses in the lung.
Recent studies have implicated amino acids, specifically tryptophan and arginine, in the regulation of immunity and tolerance. Elegant studies demonstrated an important role for tryptophan metabolism through indoleamine 2,3-dioxygenase (IDO) in inhibition of experimental asthma [1]. However, the role of arginine transport and metabolism remains unclear. Intracellular arginine is metabolized by both the nitric oxide synthase (NOS) and arginase pathways. The product of the former, NO, has been implicated in the regulation of both inflammation and airway tone. Similarly, products of the arginase pathway, such as ornithine, are regulators of key processes involved in lung inflammation, including cell hyperplasia and collagen deposition [2, 3]. Among the transport systems that mediate L-arginine uptake, cationic amino acid transporters (CAT1, -2 or -3) are considered to be the major arginine transporters in most cells and tissues [4]. We chose to focus on CAT2 because of its essential role in arginine transport in immune cells, including macrophages [5]. Defining the role of arginine and its transport protein CAT2 has been aided by the generation of CAT2-deficient mice [5]. While these mice are grossly normal, their peritoneal macrophages have a 95% decrease in L-arginine uptake and a marked impairment in NO production [5, 6]. In contrast, CAT2-deficient fibroblasts have largely intact NO production [7]. Our studies demonstrated that CAT2 is an essential part of the host protective immune apparatus in the lung in that CAT2-deficient mice displayed baseline inflammation [8], identifying CAT2 as responsible for maintenance of inflammatory homeostasis. A recent publication demonstrated that CAT2-deficient mice are significantly more susceptible to the parasite T gondii and develop enhanced fibrosis and granuloma formation in response to S mansoni [9]. Since arginine entry into the NOS and arginase pathways could have multiple effects, both positive and negative, on lung processes during pathological conditions (e.g. inflammation and fibrosis), we used CAT2-deficient mice to test the net effect of reducing transport of arginine in experimental asthma and experimental lung fibrosis.
All animal studies were approved by the Cincinnati Children's Hospital IACUC committee. Mice were bred "in house" in specific pathogen-free conditions. CAT2-deficient [5], STAT6-deficient [10] and IL-4 transgenic [11] mice were described previously. CAT2-deficient mice were either on the FVB/N or C57Bl/6 background. Both strains have been backcrossed for more than 10 generations.
Induction of experimental disease models
Mice were allergen challenged as described previously [12–14]. Briefly, mice were sensitized intraperitoneally (i.p.) with ovalbumin (OVA, 100 μg) in alum (1 mg) and challenged intranasally (i.n.) with 50 μg OVA or saline. After instillation, mice were held upright until alert. Mice were sacrificed 18-24 hours following the last challenge. For the bleomycin model, mice were treated with a single dose (0.03 U/mouse) of Bleomycin intratracheally (i.t.) and sacrificed 14 days later. Bronchoalveolar lavage was performed, and cells were counted by hemocytometer and differentiated based on morphology following Diff-Quick staining of cytospin preparations.
In situ hybridization of mouse lung
In situ hybridization was performed as described [13]. In brief, murine CAT2 cDNA was subcloned from Image Consortium clone 5344352 into pBluescript, linearized by Hind III and Not I digestion, and anti-sense and sense RNA probes, respectively, were generated by T3 and T7 RNA polymerase (Riboprobe Gemini Core System II transcription kit; Promega, Madison, WI). The radiolabeled [αS35-UTP] probes were hybridized and washed under high-stringency conditions.
Northern blot analysis
RNA was extracted using the Trizol reagent as per the manufacturer's instructions. The cDNA probe, generated from commercially available vectors [Image Consortium clone 5344352 in pCMV-SPORT6 obtained from American Tissue Culture Collection, Rockville, MD], was liberated with NdeI and MluI, confirmed by sequencing, radiolabelled with 32P, and hybridized using standard conditions, as described previously [13].
Measurement of collagen accumulation
Collagen accumulation was determined by measuring the content of hydroxyproline as previously described [8]. Additionally, fibrosis was evaluated histologically. Tissues were fixed in 10% neutral buffered formalin and paraffin embedded. Sections were stained with Masson's trichrome to evaluate fibrosis. Scoring (0-3) represents evaluation of intensity and extent of fibrosis determined by an observer blinded to treatment and genotype.
Arginase activity
Arginase activity in intact cells (peritoneal macrophages from naïve mice) was measured using incorporation of radioactive arginine as previously described [15]. Cells (2 × 105 cells/100 μl PBS and 22 mM glucose/well of 96-well-plate) were incubated with 14C-arginine (L-[guanido-14C], NEN) for 18 hours, and 14C-urea present in the cell supernatant was metabolized with urease. Released 14CO2 was collected and measured by scintillation counting. Arginase activity in lysed macrophages was measured using the blood urea nitrogen reagent (Sigma Chemical Company, St. Louis, MO) according to established techniques [16–18].
Cytokine levels
Cytokine levels were determined by Multiplex analysis on BALF supernatant samples. Analysis was performed by Millipore using the mouse 32 cytokine/chemokine panel.
Statistical analysis
Values are reported as the mean ± standard deviation. The significance of differences between groups were analyzed by ANOVA using Prism software. Pairwise comparisons were performed by Student's t-test. Differences are considered significant if P < 0.05. Trichrome staining quantification scoring was tested by Mann-Whitney U test.
CAT2 is an allergen-induced gene in experimental asthma
CAT2 in situ hybridization
CAT2 expression is not required for allergen-induced lung inflammation
CAT2 expression is required for collagen deposition following bleomycin exposure
In order to address the role of CAT2 in collagen deposition, we measured hydroxyproline levels in the lungs of bleomycin-treated mice. As seen in Figure 4B, CAT2-deficient mice had increased baseline levels of hydroxyproline (P = 0.02) as we have previously reported [8]. However, while wild type mice responded to bleomycin with increased levels of hydroxyproline, CAT2-deficient mice were unable to further increase lung fibrosis. In order to assess the fibrosis by an independent method, we stained lung tissue sections by trichrome staining. As seen in Figure 4C, both wild type and CAT2-deficient mice had areas of fibrosis and tissue consolidation accompanied by inflammation, which is typical of day 14 lung sections in bleomycin-induced fibrosis. When sections were scored for intensity and extent of involvement by an observer blinded to treatment, the level of lung tissue fibrosis/consolidation was significantly decreased in CAT2-deficient mice compared with wild type mice (Figure 4D and 4E). Control mice of either genotype did not show histological evidence of fibrosis/consolidation or inflammation (Figure 4C, D and data not shown).
CAT2 requirement for macrophage arginase activity
Recent studies have suggested a role for arginine transport and metabolism in a variety of inflammatory disorders. In this report, we used CAT2-deficient mice to test the role of arginine transport in lung inflammatory conditions, including experimental asthma and bleomycin-induced lung fibrosis. Our studies revealed several novel findings. First, we demonstrate that CAT2 mRNA expression is induced in experimental asthma and that the main cell type expressing it is a mononuclear cell most consistent with alveolar macrophages. Second, we demonstrate that CAT2 is required for bleomycin-induced pulmonary fibrosis. Third, in contrast to the fibrosis data, we show that CAT2 expression is not required for lung inflammation in either allergen-induced or bleomycin-induced models. Finally, we show that CAT2 is partially required for arginase activity in macrophages, which may contribute to the development of fibrosis.
Even though CAT2 is induced highly in asthma, it is not required for experimental asthma-induced inflammation. This observation is consistent with our recent finding that arginase is not required for allergic airway inflammation, despite high level of induction [20]. In contrast, CAT2 was recently shown to have an important, host-protective role in parasitic infestation models [9], similar to studies which demonstrated a role for arginase expression in host defense in models of parasite infestation (including Schistosome mansoni, Heligmosomoides polygyrus, Leishmania sp, Toxoplasma gondii and Nipostrongylus brasiliensis) [21–26]. In summary, our data suggest a divergent role for arginase I and CAT2 in allergic inflammation compared to parasitic responses. Since arginase and CAT2 are prominent products of alternatively activated macrophages, which are induced by IL-4 in both allergic and parasitic responses, our data suggest that alternatively activated macrophages evolved to combat parasitic infections and are either bystanders in allergic inflammation or have developed other effector molecules for allergic Th2-associated responses. In contrast, we have previously demonstrated that CAT2 has a suppressive role in baseline inflammation [8]. We speculate that resident immunosuppressive macrophages require CAT2 for the maintenance of inflammatory homeostasis in the lung, whereas highly activated M2 macrophages express CAT2 but do not require it for the inflammatory process.
Similarly, the role of CAT2 in fibrosis is context-dependent. Baseline fibrosis is increased in CAT2-deficient mice as measured by the whole lung hydroxyproline assay [8]. Interestingly, this baseline fibrosis is not evident histologically by trichrome staining, especially when slides are scored by an observer blinded to genotype and treatment. We did not assess allergen-induced fibrosis because fibrosis does not develop in the acute OVA-induced model. However, we used a well-characterized model of bleomycin-induced fibrosis, which has previously been shown to exhibit induced transcription of CAT2 [19]. Interestingly, in this model fibrosis is dependent on CAT2 as measured by either whole lung hydroxyproline measurement or blinded quantification of trichrome staining. Since previous studies have shown that proline synthesis (often a rate-limiting step in collagen synthesis) is downstream of CAT2 and arginase, we tested the hypothesis that CAT2 is required for arginase activity in macrophages. We found a notable requirement, suggesting a possible role for arginase in the CAT2-mediated fibrosis.
The requirement for CAT2 for arginase activity in macrophages is controversial. Thompson et al. [9] demonstrated that CAT2-deficient macrophages and fibroblasts have increased arginase activity. However, their assay was performed with ruptured cells and exogenously added arginine (250 mM; Km for arginase is ~5 mM) thus circumventing the function of arginine transport into the cell. Yeramian et al. [27] demonstrated decreased arginine catabolism into ornithine and polyamines in CAT2-deficient alternatively activated macrophages, suggesting the requirement for CAT2 for arginase activity in intact cells. In order to directly test the role of CAT2 in arginase activity, we used the whole cell arginase activity assay [15]. Importantly, as opposed to the assay used by Thompson et al. [9] and by us in lysed macrophages (Figure 5B) that assesses the arginase activity in ruptured cells or tissues and is thus primarily a reflection of the amount of arginase expression, the whole cell assay accounts for the role of trans-membrane transport for arginase function. We used peritoneal macrophages since we were unable to collect sufficient numbers of lung macrophages for this assay. Our data demonstrate a partial requirement for CAT2 for arginase activity in intact macrophages, suggesting either an alternative transporter or intracellular pool of arginine can contribute to arginase activity. This is in contrast to NOS activity, which depends on arginine transport from the extracellular space [15, 28, 29].
In summary, we have described a pathway (involving CAT2 and arginine homeostasis) not previously examined in the context of lung inflammation and fibrosis. We find that while CAT2 is highly upregulated in experimental asthma, it does not have a role in allergic airway inflammation. Rather, CAT2 is critically important for interstitial lung fibrosis.
bronchoalveolar lavage fluid
cationic amino acid transporter
nitric oxide synthase
signal-transducer-and-activator-of-transcription 6
The authors wish to thank Laura Koch, Amy Hajek and Erin Zoller for technical assistance; Dr Keith Stringer for assistance with in situ hybridization; Drs. Carol MacLeod, Sidney Morris and Ariel Munitz for critical discussions, reagents and technical advice; and Shawna Hottinger for final edits to the manuscript. This study was funded in part by the March of Dimes grant FY06-345 (to NZ) and by NIH R01 AI53479-01 (to MER and NZ). Neither the March of Dimes nor the NIH participated in study design, collection, analysis or interpretation of data, writing of the manuscript or the decision to submit the manuscript. MGC is currently at Technical Resources International, Inc. in Bethesda, Maryland.
Authors' Affiliations
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- Li H, Meininger CJ, Kelly KA, Hawker JR Jr, Morris SM Jr, Wu G: Activities of arginase I and II are limiting for endothelial cell proliferation. Am J Physiol Regul Integr Comp Physiol 2002, 282:R64-R69.PubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Wear your crown of a Selfie King proudly with this mount frame hung on your wall. The frame is available in sizes 38x50 cm and 32x42.5 cm. It is made of solid wood which is 1" wide and 0.40" deep, and the mount sheet is 2.5" with the bigger frame and 2" with the smaller frame. It also has a dust cover provided at its back.


text: Someone's Figured Out Where One Million Internet Cats LiveYannick LeJacq7/29/14 1:45pmFiled to: catakuthe internetcatsi know where your cat livesbig data345EditPromoteShare to KinjaToggle Conversation toolsGo to permalink This goes without saying, but people love posting pictures of their cats online. They love it so much, in fact, that they're often willing to forego little things like "privacy" and "self-respect" in favor of bringing their furry friends to the widest possible audience. Advertisement A new data-driven project throws the gratuity of all this feline-flaunting into sharp relief, and gives an important lesson about digital privacy in the process. It's called "I Know Where Your Cat Lives." As the name suggests, it's an interactive map that lets you pinpoint the exact location of one million cats—or, at least, the cat's location when they were photographed and had their likeness uploaded for all to see online. As the name also suggests, the findings are more than a little disconcerting. Because if you take the cats out of the picture here (heretical as that may seem), you're left with something fairly Orwellian.The million-strong cat-map was made by Owen Mundy, an artist and programmer who teaches at Florida State University. In a description of the project on his blog, Mundy says that he found all the cats featured on the site by sifting through publicly available data that he could pull from social networks and photo-sharing sites simply by searching for the word "cat." He then compiled these results and ran them through "a supercomputer at Florida State University in order to represent the enormity of the data source." These findings only accounts for cat photos that people bothered to tag as such, mind you. But even then, Mundy says he got more than 15 million hits. Thousands more are being uploaded every day as well. As a result, Mundy scaled back his original ambitions to only account for one million. Advertisement Even with smaller sample size, the results here are staggering and fairly creepy. Being able to hone in on the exact latitudinal and longitudinal coordinates for a given cat seems silly at first. But Mundy reminds us that "I Know Where Your Cat Lives" doesn't actually document all living cats, but "only the ones that allow you to track where their owners have been." So the next time you open up Instagram to post pictures of Mr. Fluffykins, remember: you could also be inviting the entire internet to geolocate you and your cat. And Mr. Fluffykins doesn't want that, now does he? Advertisement Sponsored Mundy is also running a modest Kickstarter campaign to spruce up the "I Know Where Your Cat Lives" website.via The Atlantic Advertisement To contact the author of this post, write to email@example.com or find him on Twitter at @YannickLeJacq.Reply34 repliesLeave a reply


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--- In iris-photos@y..., Gerry Snyder <gerrysnyder@m...> wrote:
> If you are afraid of flooding the list, you could dribble them out over
> the bloomless (or almost so for many of us) period until the next season
> starts. That would make you very popular with those of us suffering from
> iris withdrawl.
Gee, Gerry, I haven't been *very popular* a day in my life! You mean, all I
ever had to do was show folks a bunch of iris pics? Why didn't anybody tell
me that when I was in grade-jr high-high school???? LOL!
It might take a little time for me to post all my pics, anyway. For one thing, TB
bloom just started yesterday in my garden. For another thing, I've been taking
numerous pics of each cv, and now I have to go through them and choose the
best to post from each cv's dozen or so pics. YIKES!
I am very pleased that you guys seem to be enjoying my pics. I'll keep
snapping and posting.
Your use of Yahoo! Groups is subject to http://docs.yahoo.com/info/terms/


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Memory Training Intervention for Breast Cancer Survivors
Recruitment status was: Active, not recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This is a randomized controlled trial to evaluate the ACTIVE memory training intervention and ACTIVE speed of processing training to waitlist, no-contact control conditions. Specific aims and hypotheses are:
Aim 1: Evaluate the acceptability and usefulness of the ACTIVE memory intervention among Breast Cancer Survivors (BCS).
Hypothesis 1: BCS assigned to the memory intervention arm will perceive the intervention as more acceptable and useful than BCS assigned to the attention control condition.
Aim 2: Establish preliminary efficacy of the ACTIVE memory training intervention relative to the attention control and no-contact control conditions.
Hypothesis 2: Memory training will result in greater memory enhancement immediately post and 2-months post-intervention relative to attention control or no-contact control conditions.
Breast Cancer
Behavioral: memory training
Behavioral: speed of processing training
Behavioral: waitlist control
Phase 2
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Supportive Care
|Official Title:
|Memory Training Intervention for Breast Cancer Survivors
- Memory Performance [ Time Frame: Baseline, immediately post, and 2-month post intervention ]Evaluate the acceptability and usefulness of the ACTIVE memory intervention among Breast Cancer Survivors.
- Subjective Cognitive Function [ Time Frame: baseline, immediately and 2-month follow-up ]Preliminary efficacy established by objective neuropsychological tests and quality of life.
|Estimated Enrollment:
|Study Start Date:
|September 2008
|Estimated Study Completion Date:
|December 2012
|Estimated Primary Completion Date:
|September 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: memory training
memory training
Behavioral: memory training
10 1-hour sessions over 6-8 weeks
Experimental: speed of processing training
Speed of processing training
Behavioral: speed of processing training
10 1-hour sessions delivered over 6-8 weeks
Experimental: waitlist control
Breast cancer survivors will be randomized to 1 of 3 groups: memory training, speed of process training or waitlist control
Behavioral: waitlist control
Breast cancer survivors will receive the speed of processing training compact disc in the mail after study completion.
Detailed Description:
|Ages Eligible for Study:
|40 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- female gender (breast cancer is rare in men);
- self-reported memory impairment and desire for treatment (to focus on BCS in greatest need);
- first diagnosis of non-metastatic breast cancer (to control for multiple treatments or brain metastases in women with recurrent or metastatic disease);
- ≥ 1 year post-treatment including surgery, radiation, and/or chemotherapy (reduce confounding factors related to acute effects of treatment);32
- age ≥ 40 years (our prior studies indicate approximately 75% of BCS meet this criterion and reduce sample variability);
- post-menopausal (majority are post-menopausal at diagnosis and reduce sample variability); and
- able to read, write, understand, and speak English (to ensure informed consent).
Exclusion Criteria:
Women will be excluded if they have other co-morbidities or deficits that would sufficiently impair performance or inhibit cognitive training including:
- substantial cognitive decline (score < 24 on the Mini Mental State Exam (MMSE);33
- history of stroke, encephalitis, traumatic brain injury, brain surgery, dementia, Alzheimer disease, or Parkinson disease;
- cranial radiation therapy or intrathecal therapy;
- current active major depression or substance abuse or history of bipolar disorder, psychosis, schizophrenia, or learning disability;
- history of or current other cancer except for basal cell skin cancer; or
- receiving other cognitive training (to avoid exposure to other training).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01497015
|United States, Indiana
|Indiana University
|Indianapolis, Indiana, United States, 46202
|Principal Investigator:
|Diane Von Ah, PhD, RN, CNA
|Indiana University
|Study Director:
|Andrew Saykin, PsyD
|Indiana University
|Study Director:
|Frederick Unverzagt, PhD
|Indiana University
|Study Director:
|Janet Carpenter, PhD, RN
|Indiana University
|Study Director:
|Patrick Monahan, PhD
|Indiana University
|Responsible Party:
|Indiana University
|ClinicalTrials.gov Identifier:
|NCT01497015 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 15, 2011
|Last Updated:
|March 27, 2012
Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Central Nervous System Stimulants
Physiological Effects of Drugs
Autonomic Agents
Peripheral Nervous System Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Adrenergic Agents
Adrenergic Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Dopamine Uptake Inhibitors
ClinicalTrials.gov processed this record on February 24, 2017


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Top Picks : National | India Current Affairs , October 2013 Current Affairs , 2013 Current Affairs
Mahatma Gandhi Pravasi Suraksha Yojana, a pension and life insurance fund scheme for blue-collar Indian workers in UAE was launched by the Union Minister of Overseas Indian Affairs, Vyalar Ravi in Dubai on 28 October 2013.
The scheme will cover 5 million overseas blue collar Indian workers who have the Emigration Clearance Required (ECR) category passports in 17 countries. ECR passports are issued to those workers who have not passed Grade 10. Around 65 per cent of more than two million Indians in the UAE are blue collar workers and most of them are in the ECR category.
Blue collar jobs are pertaining to wage-earning workers who wear work clothes or other specialized clothing on the job, as mechanics, longshoremen, and miners.
About Mahatma Gandhi Pravasi Suraksha Yojana
1.Mahatma Gandhi Pravasi Suraksha Yojana (MGPSY), a special social security scheme for overseas Indian workers on temporary work permit in 17 Emigration Check Required (ECR) countries.
2.The MGPSY is aimed at helping the workers to save money for their retirement, their return to India and resettlement and provides life insurance cover against natural death during the period of coverage.
3.It provides home and a life insurance cover for 1 lakh rupees during their work abroad.
4.The Government of India will contribute up to 2000 rupees every year for male workers and 3000 rupees every year to women workers for up to either five years or until the worker returns home, whichever is earlier.
5.It will be added to the Pension and Life Insurance (PLIF) account of each eligible subscriber.
6.The workers have to contribute between 1000 rupees and 12000 rupees per annum towards the pension fund and 4000 rupees towards the return and resettlement fund. They will derive corresponding benefits when they go back home and during their old age.
7.Indian Workers Resource Centre or IWRC is the support center for Indian workers in the UAE while Bank of Baroda is the official banking partner of the scheme to enroll the workers.
Who: Government of India
Where: Dubai
What: Mahatma Gandhi Pravasi Suraksha Yojana
When: 28 October 2013
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Browse other items in the Cassidy collection from Wayside Furniture in the Akron, Cleveland, Canton, Medina, Youngstown, Ohio area.
The Cassidy King Bedroom Group by Crown Mark from Wayside Furniture. We proudly serve the Akron, Cleveland, Canton, Medina, Youngstown, Ohio area. Product availability may vary. Contact us for the most current availability on this product.
Combining modern bones with a rustic finish, this versatile collection will fit in well with a number of decors. Pieces in the collection have simple, cleans lines with slightly recessed drawers, square block feet, and simple crown molding. The handsome sleigh bed has two drawers built into the footboard, providing a great way to save space in smaller spaces.
The Cassidy collection is a great option if you are looking for Rustic
Contemporary furniture in the Akron, Cleveland, Canton, Medina, Youngstown, Ohio area.
These images are representative of this group as a whole and may differ from this item.
Nothing on this page may be copied or reproduced without explicit permission.
Drag anItem Here
To start a new blank room plan, enter the desired room dimensions below and click Create Room.
To request a new password, enter your username or e-mail address and click submit. A new password will automatically be emailed to you.
If you are still having trouble logging on after receiving your new password, please email email@example.com


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Latest News
May 3, 2016BMC Stock Holdings Inc. expanded its supplier partnership with Marvin Windows and Doors into the Middle and South Atlantic regions of the United States, including several growing metropolitan areas across Pennsylvania, Virginia, North Carolina and South Carolina. BMC Stock will now have 34 Marvin dealer locations in seven states. "The expansion of our Marvin partnership allows us to... more »
May 3, 2016India-based Global Metal Co. recently launched a solution to help bulk buyers to print instant quotations for builder hardware products, according to company officials. The online tool, available on the company's website, generates instant quotations based on the criteria set by the buyers on a real time basis. The algorithm automatically calculates the product price based on... more »
May 3, 2016For the 19th consecutive year, Therma-Tru has ranked highest for Brand Specified/Used Most in the entry doors category of the 2016 Builder Brand Use Study. It also ranked highest for Brand Specified/Used Most in the past two years. "We're honored that builders continue to turn to Therma-Tru for their entry door needs," said Brett Finley, president, Therma-Tru Corp.... more »
May 3, 2016In time for the summer driving season, consumers can enter to win a $125 gas card in Simpson Door Co.'s "Take a Simpson Door for a Test Drive" sweepstakes. Simpson's Test Drive a Door is a free and easy-to-use online app for selecting exterior or interior doors, which allows homeowners to upload a photo of their home and view how any Simpson door will look on it... more »
April 26, 2016Edgetech Europe GmbH announced that beginningin Spring 2016, its Heinsberg, Germany, facility will begin producing Super Spacer TriSeal Premium Plus. A non-metal warm-edge spacer system with integrally incorporated desiccant for both residential and light commercial insulating glass units, Super Spacer TriSeal Premium Plus is a Passive House-certified product that... more »
April 22, 2016Associated Materials, manufacturer of Alside, Gentek, Revere and Preservation branded windows, announced that its Central (Cuyahoga Falls) window manufacturing operation has been awarded the prestigious ISO 9001:2015 certification for meeting or exceeding rigorous quality assurance standards – and is one of only a few U.S. window companies with ISO 9001 certification, according to a... more »
April 22, 2016Crystal Window & Door Systems in conjunction with New York-Presbyterian/Queens Hospital and the Chinese American Nursing Association recently launched a special health initiative for its employees. On the morning of April 15, 2016, over 70 Crystal employees volunteered to be test screened free of charge for chronic obstructive pulmonary disease (COPD). The New York-Presbyterian/Queens... more »
April 22, 2016Jeld-Wen Windows and Doors has earned the Greenguard Gold Certification. Greenguard Gold Certification is awarded by UL Environment, a division of Underwriters Laboratories, which provides an in-depth review and analysis of chemical emissions from Jeld-Wen's products. Greenguard Certified products aid in the creation of healthier indoor environments, and release fewer pollutants that... more »
April 22, 2016Jeld-Wen launched the first of three training programs for builders, remodelers, architects and dealers. The company's approach focuses on giving customers access to training when and where it's most useful for their businesses, according to company officials. The training programs include mobile showrooms, regional learning centers, and e-learning courses. "Given the... more »
April 22, 2016Simpson Door Co.'s 2015 Ideabook, produced in both print and interactive online formats, was honored as the Best Manufacturing Interactive application in the 2016 Internet Advertising Competition Awards.The online version of the Inspiration at Your Door Ideabook enables viewing of product videos and web content for multiple platforms, including mobile devices, for an immersive door... more »


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"I am particularly happy that we have gathered in Saint Patrick's Cathedral. Perhaps more than any other church in the United States, this place is known and loved as 'a house of prayer for all peoples...' "
For more than 130 years, St. Patrick's Cathedral has graced the City of New York, signaling welcome to all who seek
tranquility and renewal.
To many, St. Patrick's Cathedral is a spiritual haven. Parishioners, community members and travelers from around the globe find their way to this sacred home, which may truly be called the center of Catholic life in the United States. To countless others, St. Patrick's is an iconic New York City and national landmark.
Today, the Cathedral serves more than five and a half million visitors each year as a house of prayer and a place of hope.
Join us in preserving this treasured landmark for generations to come. The restoration of St. Patrick's Cathedral will be made possible by people like you.
Today, thanks to thousands of supporters, we have reached the $100 million milestone. Our goal is approximately $175 million dollars. We are on track to complete the restoration in December 2015, with most of the visible work to be completed by end of July 2015.
The phases include the interior and exterior of the Cathedral from 5th Avenue to the high altar. Key scopes of work in these phases are the restoration of the gallery organ, the Cathedral's pews, stained glass windows, exterior stonework, altar niches and ceiling plasterwork. Efforts are underway to secure the additional funding for the remainder of the work on the Cathedral campus, including the high altar and Lady Chapel, a new heating and cooling system, and the Cathedral garden.
If you would like to learn more about our efforts on behalf of St. Patrick's, please contact:
Bettina Alonso
Campaign Director
1011 First Avenue
New York, NY 10022
(646) 794-3393
You may also give online through our secure donation form.
Give Now
The restoration of St. Patrick's Cathedral will be made possible by people like you. Just as Archbishop Hughes in the 1860's asked for donations no matter how large or small, today Cardinal Dolan asks that our community of visitors, worshipers and admirers of this Gothic beauty unite in support of the restoration.
Funds raised in support of this historic restoration of St. Patrick's Cathedral will be directed to and managed by the St. Patrick's Cathedral Landmark Foundation, a new 501©(3) established specifically for the purpose of preserving and maintaining St. Patrick's Cathedral.
Now that the bulk of the restoration is over, check out some of the differences as seen through our website's banners.


text:
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Pasta and Egg Salad
Ham and Asparagus Lasagna
Ham, Cheese and Potato Salad
California Club Turkey and Pasta Salad
Ham and Broccoli Quiche
Creamy Ham and Tortellini
An easy mustard dressing makes the perfect accompaniment to this satisfying pasta salad, with chunks of ham and bright, crunchy vegetables.
The secret to evenly cooked pasta that doesn't stick together is a large pot of continuously boiling water. Use a pot large enough for the pasta to move around freely, and keep the water boiling.
You can substitute chopped cooked turkey or chicken instead of the ham if you like.
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You can't teach people to be creative, but you can inspire them to find their creativity. That is what happens at Adobe MAX. Read More »
AdobeMAX: Unleashing Your Creative Weirdo
A model, a DJ, and sugar skulls highlighted "Unleashing Your Creative Weirdo" at AdobeMAX, and that was just before the break. This workshop was one of a series of classes, speeches, and hands-on practice available at the LA Convention Center, October 5-7. AdobeMAX brings together users of Adobe software, such as Photoshop, InDesign, Premiere Pro, and Acrobat, with the engineers, developers and other people at Adobe Software who make the magic happen. Read More »
Software Review: 'Magix Samplitude Pro X2'
Magix adds even more tricks to what was already the most complete audio workstation, in 'Samplitude Pro X2' and the suite. Newcomers might be intimidated by the interface, but Magix has done almost all they can to make it easier for the user. Read More »
Software Review: 'Magix Fastcut'
With a good amount of features, Magix Fastcut is an intuitive, easy to use solution for GoPro and other action cam users. Read More »
Software Review: Adobe Creative Cloud for Photographers
With Adobe's new software model. instead of drastic revisions with major releases, there will be ongoing updates to keep th technology dynamically improving over time. Read More »
Software Review: Autodesk Entertainment Creation Suites 2014 Ultimate: 3ds Max & MotionBuilder
This, the first of three reviews, covers 3ds Max and MotionBuilder. Read More »
Software Review: Xara Photo and Graphic Designer v9
Adobe's Photoshop and Illustrator, while powerful tools, require a lot of study to be able to use proficiently. And yes, there are simpler tools out there. But is there a happy medium. Read More »
Software Review: Magix Video Pro X5
There isn't one software solution for everyone, but at half the price of Adobe's premium offering, Video Pro X5 is at least worth a look. Read More »
Book Review: The Artist's Guide to GIMP: Creative Techniques for Photographers, Artists, and Designers by Michael J. Hammel
The Artist's Guide to GIMP is an excellent guide to some of the more advanced features of the GIMP software suite. Read More »
Don't Rush To Buy OS X Lion Just Yet
Lion debuts, but not without some bugs. Read More »


text:
Data published yesterday by the British Bankers' Association (BBA) revealed that gross mortgage lending soared to pounds 4.97bn in March, pounds 1.36bn higher than in February and 31 per cent higher than in March 1998.
Net lending rose by more than pounds 1bn for the fifth successive month, and there was a near doubling in the number of approvals.
Tim Sweeney at the BBA said: "In the current interest rate environment, the strong approvals data suggest that the upturn could be sustained in the months ahead."
The Bank of England's recent string of aggressive interest rate cuts has prompted sharp falls in many mortgage rates and sparked a recovery in the housing market.
There have been marked increases in house prices in most of the country, especially in Greater London, and analysts are bullish about market prospects.
Neil Parker, economist at Royal Bank of Scotland, said: "It's pretty clear that the scale of the rate cuts has given a second wind to the housing market. I think we're going to see quite significant gains in prices this year."
Meanwhile, the latest quarterly forecast by the National Institute of Economic and Social Research (NIESR) will add to the growing economic optimism when it is published later today.
The NIESR has upped its forecast for growth this year from 1 per cent to 1.25 per cent - in line with the Government's 1 to 1.5 per cent forecast.
It argues that the recent recovery in confidence should help the economy achieve a soft landing.
The pace of the UK recovery will accelerate during the course of the year, according to the NIESR, and growth in 2000 now looks set to approach 2.5 per cent.
The flipside of the pick-up in growth is a rise in inflation, which is forecast to overshoot the Government's 2.5 per cent target during next year. The scope for further interest rate cuts is limited, the NIESR says.
Like other commentators, it warns that the UK will increasingly become a "two speed" economy, with the service sector booming, but manufacturing mired in recession.Reuse content