text:
- Hi there, welcome to Tribesmart. Log in to get started...
Planet Earth - The Complete BBC Series
Guide price: $25
Last updated on 23rd Apr 2010
Planet Earth - The Complete BBC Series
With an unprecedented production budget of $25 million, and from the makers of Blue Planet: Seas of Life, comes the epic story of life on Earth. Five years in production, over 2,000 days in the field, using 40 cameramen filming across 200 locations, shot entirely in high definition, this is the ultimate portrait of our planet. A stunning television experience that captures rare action, impossible locations and intimate moments with our planet's best-loved, wildest and most elusive creatures.
From the highest mountains to the deepest rivers, this blockbuster series takes you on an unforgettable journey through the daily struggle for survival in Earth's most extreme habitats. Planet Earth takes you to places you have never seen before, to experience sights and sounds you may never experience anywhere else.
DVD Features:Other:110 minutes of behind the scenes footage - one 10-minute behind the scenes program for each episode (SD release only)Documentary:Planet Earth - The Future: This 3-part, 2 1/2 hour series looks at what the future may hold for endangered animals, habitats and -- ultimately -- ourselves. Following the environmental issues raised by Planet Earth, it asks why so many species are threatened and how they can be protected in future.
(SD release only)
Login or Register to add this to your wish list or favourites.


text:
A&W Root Beer
Doctor Pepper
Grape Crush
Orange Crush
These are sure to excite candy lovers even without the caffeine!
Kosher Certified
* Please Note: This product is only Kosher Certified when purchased in 10 lb. quantities.
Jelly Belly Soda Pop Shoppe Soda Pop Shoppe Jelly Belly Jelly Beans are a cute assortment of miniature plastic soda bottles filled with the following, realistic, tasty and unique Jelly Belly Jelly Bean Flavors!
- Price: $49.03

subset: commoncrawl


text:
Silica Gel Cat Litter (Silica Gel Pet Litter), offered by us, is perfect to absorb the urine and fecal odor of the pets. Silica Gel Cat Litter is prepared is such a way that it can easily curb the bacterial growth, and also keep the hygiene. Features : Perfectly absorb volatile gasesSuper-fast absorptionStrong deodorantAnti-bacterial functionKeep the air and environment cleanReduce the master's labor intensityMore ef
Trade-link (mfg.silica Gel) (silica Gel- White-blue-orange-..
T-18, 3rd Floor, Saundarya Square Complex,opp.perfect Plaza, Radhanpur Road, Mehsana, Gujarat - 384002, India
Located in Navi Mumbai(India), we are a high-flying name when it comes to quality-centralized and cost effective products. We have developed several offline as well as online options for the convenience of clients to ensure faster trade. more... less...
Priyancy Enterprises
Office No. 604, Vashi Infotech Park, Plot No.16, Sector 30a, Vashi, Maharashtra - 400703, India
We offer cat litter. Specification of cat litter bentonite granules parameters result ph 8.5 to 9.5 size 0.5 to 5mm specific gravity 2.4 – 2.8 gmml moisture 12% properties highly absobent & super clumping fragrance without fragrance odor odorless more... less...
Pitrukrupa Minerals
Momaymora Taluka, Mandvi, Gujarat - 370445, India
We are offering cat litter. A litter box, sometimes called a sandbox, litter tray, litter pan, or catbox, is an indoor feces and urine disposal box for cats (as well as rabbits, ferrets, small dogs such as beagles and chihuahuas, and other pets that naturally or through training will make use of such a repository) that are permitted free roam of a home but who cannot or do not always go outside to relieve themselves.
Shree Minerals
3, Darbar Chambers, Baroi Road, Gujarat - 370421, India
Post your Buy Requirement
In order to maintain high-quality standards in our offerings, we make use of the finest grade raw material. Also, we ensure that the material is sourced from the reliable places only. All those who are looking for a responsible name supplying Cat Litter can get in touch with us!
Satyalaxmi Minerals
Satyalxmi Minerals, Gujarat , India
Dedicated towards bringing forth the finest and premium quality Cat Litter, we are a well-established Supplier in this domain. Quality control is a huge part of our company and we make sure, all our products are quality assured and trustworthy.
Surya Group
Hyderabad, Andhra Pradesh , India
Hailing from Bikaner(India), we are catering to the nationwide requirement with our superior products. To maintain availability of products all year round and escape the issue of stock-out, we have established a state-of-the-art warehousing building and incorporated it with the latest inventory control system.
Shanti Enterprises
Outside Jassusar Gate, Rajasthan - 334004, India
Our team experts are capable of maintaining database containing complete transactions made by our customers and thus, you can trust us for the online or offline payments made. We are strategically based in Vijayawada(India) and are in proximity with the resources required for easy production process.
First Floor, Nalluri Dharmarao Complex, Behind E-seva, Patamata, Andhra Pradesh , India
We stringently follow automated warehousing system that helps us in meeting the safe storage requirements. Thus, we ensure zero damage to the products till the final dispatch. Placed in Maharashtra(India), we share space with the top-notch Suppliers, domestically and offer top-of the line array of in the market.
Ashapura Exports, Mumbai
276, D N Road, Fort, Mumbai, Maharashtra - 400001, India
We are exporters & supplier of bentonite cat litter from kutch gujarat. we are supply cat litter with scanted & non scanted with high clumping. more... less...
Unique Impex
Office No - 2, Lokhandwala Complex,rnbhid Bazar, Rnmandvi - Kutch, Gujarat - 370465, India
Ashapura manufactures a wide range of Cat Litters from both Bentonite based heavy wt litters to Attapulgite based light wt litters also called traditional cat litters. Ashapura supplies in bulk the various grades of cat litter to different locations where they are further packaged into small bags.
Ashapura Minechem Limited
Fort , India, Maharashtra - 400001, India
We are offering desiccant benonite cat litter clumping.
Sai Dhurga Enterprises
1465, 3rd Cross, Mariappan Palaya, Rajajinagar, Karnataka - 560021, India
With immense knowledge and expertise in this domain, we have made our position in the domestic market by providing Cat Litter. We have the moat upgraded machines and technology to make sure that the raw material is completely in compliance with the set standards. This helps us in presenting good quality and defect free products.
Unique Impex
Mandvi - Kutchh, Gujarat , India
We are manufacturer of cat litter (pet litter) from kutch. we are supply of cat litter non- scanted & scanted as per size. We are supply cat litter size in 0.5mm to 2.0mm & 2.0mm to 5.0mm more... less...
Mayur Minerals
Maska Industrial Area, Mandvi - Kutch Gujarat, Gujarat - 370465, India
Buyers can contact us all year round for purchasing reliable Cat Litter at market leading prices. In our well-constructed warehouse, we store the entire lot under safe conditions and away from various damaging factors such as direct sunlight, moisture, dust, rain and others.
Aa Pets
D-49,defence Colony, New Delhi-110026 Delhi, Delhi - 110026, India
We are offering cat litter.
Pet Destination
Pet Destinationrnshop No. 901, Before Darsham Bagh Studio, Orbit Villa Lane, O/p B.b Nair Bungalow, Maharashtra - 400061, India
The basic materials that we use for the manufacturing of our entire range are thoroughly checked against numerous quality parameters. Thus, we make sure that we deliver faultless products to the clients. From bulk to retail order fulfillment, we can do it all. Our company has a wide supply chain network to provide our buyers with the product all year round and make timely delivery.
Neelkanth Rockminerals Ltd
A-103, 2nd Floor, J. D. Arcade, Opposite Medical College, Jaljog Circle Jodhpur - 342003, Rajasthan , India
Post your Buy Requirement
Amonia controlKeep home fresh & cleanIt's safe, healthy & 100% earth friendly Net Weight : 10 Liter
Gold Stone Minerals
1st Floor, Opp Jain Nutan School K.t. Shah Road, Mandvi, Gujarat - 370465, India
We will not let you wait much, as we have trustworthy shipping facilities available to deliver the same in set time. Staffed with a pool of deft professionals, we are capable to deliver high quality lot to the patrons. And, we also make sure that the products are packed using the best quality material.
Golden Stone
Bhuj (kutchh), Gujarat, Gujarat , India
GreeNeem Eco Soft Cat Litter or Kitty Litter is Non Toxic Biodegradable Natural Plant Fiber product , from renewable source (Coir) and is free from clay, chemical, fragrance, dust. It is safe, soft, pleasant, long lasting, fully compostable and controls odor. Can be used for other small animals and pets. For More information kindly visit us at
M/s.greeneem Agri Pvt Ltd
3-229,varalotti Villipathri Post, Tamil Nadu , India
Greeneem eco soft cat litter or kitty litter is non toxic biodegradable natural plant fiber product , from renewable source (coir) and is free from clay, chemical, fragrance, dust. It is safe, soft, pleasant, long lasting, fully compostable and controls odor. Can be used for other small animals and pets.
Greeneem Agri Pvt Ltd
3-229, Varalotti, Villipathri Postrnvirudhunagar, Tamil Nadu - 626001, India
Deals in dog jacket, Dogs Clothing, Smarty Pet Paws, Trixie Protective, Pawzone Choke Collar
Heads Up For Tails
Second Floor (across Good Earth), A3 District Centre, Saket, New Delhi, Delhi, Delhi - 110017, India
Deals in Roaasted bentonite granular, Bentonite, Cattle Feed Grade Bentonite, Bentonite Powder, Bentonite granules, Calcium Bentonite
Avni Claytech Pvt. Ltd.
43,rajapur Allahabad., Uttar Pradesh , India
Deals in Bird Feed, Fish Food, Aquarium Accessories, Dental Care Stick Pet Food
Pisces Impex
Door No.18 South Mada Street Kolathur Near Ganga Cinema Chennai - 600099 Tamil Nadu India, Tamil Nadu , India
Deals in chews, Nail, asha pura cat litter, classic dog food, cat food, dog chains, dog articles, Balls, shampoos, meo cat food, chokers, cart articles, soaps
Kennel Dogy Articles
151/155, Sarang Street, Shop No. 2, Opp. Crawford Market, Next To Hotel Sadanand, Opp. Cafe Firdos, Maharashtra - 400003, India
Silica Gel Pet Litter / Silica Gel Cat Litter Cat litter, in seconds, can absorb pets urine and fecal odor, can curb bacterial growth, and maintain the surface of cat litter dry and clean and keep safe of pets sanitation. While cat litter can absorb volatile gases, water adsorption in the air, it plays the role of air fresheners, keeping air and environment clean. Due to the unique properties of silica gel cat litter
Trade-link (mfg.silica Gel) (silica Gel- White-blue-orange-..
T-18, 3rd Floor, Saundarya Square Complex,opp.perfect Plaza, Radhanpur Road, Mehsana, Gujarat - 384002, India
We "GOLD STONE MINERALS."are Manufacture & mine owner from kachchh, Gujarat(India). With a quality product of all Grade Bentonite. We are Manufacturer / Exporter of Bentonite & Bentonite Powder. We are Manufacturer of, Foundry Grade Bentonite, Pilling Grade Bentonite, Drilling Grade Bentonite (API 9 Bentonite), API 11(OCMA)Bentonite, Bentonite Granules, Fertilizer Grade Bentonite, Civil Engineering grade, Cosmetics G
Gold Stone Minerals
1st Floor, Opp Jain Nutan School K.t. Shah Road, Mandvi, Gujarat - 370465, India
We are offering Clay Cat Litter. Maxsorb* cat litters made from natural montmorrilinite clay, available in clumping & non clumping type maxsorb* cat litter absorbs moisture quickly and controls odors effectively. montmorrilinite is most economic natural cat litter available. It has ability to absorb water several times of its own weight and give thick tropic fluid. This is a traditional clumping & non clumpin
Sai Dhurga Enterprises
1465, 3rd Cross, Mariappan Palaya, Rajajinagar, Karnataka - 560021, India
We are manufacturing Clumping & Non-Clumping Cat litter from Natural Clay. Our Cat Litter is 100% natural, free form harmful content, dust free absorbing large volume of waste. Our Cat Litter have ability of odor control, instant clumping, hard clump & super economic. We have Clumping & Non-Clumping Cat litter in Varies Size like 0.2 mm to 1 mm, 0.5 mm to 2 mm & 1 mm to 5 mm and also have different perfumed like' L
Gold Stone Minerals
1st Floor, Opp Jain Nutan School K.t. Shah Road, Mandvi, Gujarat - 370465, India
Clumping Cat Litter (clean Pick)
Our cat litter is made from natural clumping clay which deodorizes naturally, helping to keep the tray smelling fresh and clean. When soiled, the clumps can easily be removed, leaving only clean litter. As only solid clumps are remover. Our cat litter is very economical to use. Benefits Economical clumping clay granulesOnly soiled clumps need be removedHighly adsorbentDeodorizes naturally100% naturalNo harmful chemic
Gold Stone Minerals
1st Floor, Opp Jain Nutan School K.t. Shah Road, Mandvi, Gujarat - 370465, India


text:
With Instructables you can share what you make with the world, and tap into an ever-growing community of creative experts.
this should work its really simple you will need saved shsh blobs for ios an ios firmware file that matches the blobs latest version of redsn0w
there are many instructions on the web and redsnow has some
run redsnow and go into the menus extras>even more>restore then follow the instructions
Jailbreak iOS5!by astroboy907
Jailbreak your ipod touch, iPad or iPhone on 3.1.3 firmwareby RedFlash
Jailbreaking an IDevice Running IOS 6.1.6by KVNALBlog1
Join 2 million + to receive instant DIY inspiration in your inbox.
© 2016 Autodesk, Inc.


text:
In Kelly Romo's novel, we are introduced to the lengths that people will go to when in trouble or need. Read More »
Book Review: 'Illegal To Legal – Business Success for (ex) Criminals' by Bob Pelshaw – A man with a mission.
Author Bob Pelshaw is on a mission to reduce recidivism among his fellow former inmates through encouraging businesses to hire them and provide them the skills to reintegrate themselves. Read More »
Disappearing Mugs from the Unemployed Philosopher's Guild
A hot cup of coffee changes everything. Read More »
Book Review: "Thinking in New Boxes" by Luc de Brabandere and Alan Iny
An excellent manual of business creativity will appeal to anyone seeking to reinvent himself. Read More »
Book Review: 2012: Midnight at Spanish Gardens by Alma Alexander
Life changes at the end of the world. Read More »
Book Review: When A Woman Inspires Her Husband: Understanding and Affirming the Man in Your Life by Cindi McMenamin
Candid and surprising insights on what can help draw a husband closer to his wife. Read More »
Book Review: A Master @ Life!: Dare to Imagine, Dare to Change by Harold L. Lamma II
You can learn how to transform your life into a life that you love. Read More »
The Changing Face Of Glastonbury 1970-2011
Join me on this journey of adventure as we uncover the changing face of Glastonbury. Read More »
Music Review: Tye Tribbett – FRESH
The day change suddenly altered the direction for Tye Tribbett. Read More »
DVD Review: Seeing, Searching, Being: William Segal
Visit Paris and artist William Segal in this fascinating Ken Burns documentary. Read More »


text:
Staff profile
Murat Yasar
Assistant Professor
Current projects:
- Manuscript: The North Caucasus Borderland: Imperial Entanglements and Shifting Loyalties, 1555-1605.
- Article: "The North Caucasus between the Ottoman Empire and the Tsardom of Muscovy: The Beginnings of an Imperial Rivalry."
Specialty areas:
- Near and Middle Eastern History
- History of the Ottoman Empire
- Ottoman and Islamic Borderlands
- History of the Caucasus and Eurasian Steppes
- Ottoman-Russian Relations
- Minorities in the Middle East
- Historical GIS
- Digital History
- "Evliya Çelebi's Travels in the Circassian Lands: Vampires, Tree Worshippers, and Pseudo-Muslims." Acta Orientalia 67 (2014): 75-96.
- "Learning the Ropes: The Young Turk Perception of the 1905 Russian Revolution." Middle Eastern Studies 50 (2014): 114-128.
- "Teaching Middle Eastern History in North America: Challenges and Prospects." Perspectives on History 51 (2013): 33-35.
- "The North Caucasus in the Second Half of the Sixteenth Century: Imperial Entanglements and Shifting Loyalties." Ph.D. Dissertation, University of Toronto, 2011.
- "The Russians and the Turks: Imperialism and Nationalism in the Era of Empires." In Imperial Rule. Edited by A. Miller and A. J. Rieber, 27-47. New York: Central European University Press, 2004. [with Norman Stone and Sergei Podbolotov]
Ph.D., The University of Toronto, 2011
MA, Bilkent University, 2003
BA, Middle East Technical University, 2001


text:
Hot Products:ABCDEFGHIJKLMNOPQRSTUVWXYZ0123456789
LightingEXP Byoou Links
All Offers/Products/Company Profiles/Images and other user-posted contents are posted by the user and By-Trade-Shows shall not be held liable for any such content. However, By-Trade-Shows respects the intellectual property, copyright, trademark, trade secret or any other personal or proprietary third party rights and expects the same from others. Read intellectual property policy and for infringement claims Feedback.W3C Validator this document


text:
Dogwoods - Sequoia National Park
High atop California's Sierra Nevada mountains, nestled and sheltered by the
largest trees on earth, the delicate Dogwoods bloom. Early spring moisture
from Pacific is lifted skyward by the massive peaks turning in to towering
thunderstorms. Mist forms and moves quickly in and out of the Giant Sequoia
forest and the snow melts from all but the highest peaks. The dense rain
forest protects the large dogwood blooms which pass quickly as summer
approaches. Most will visit during the burning summer months but the real
magic occurs during inclement weather.
© Darvin Atkeson
13,289 views
248 faves
101 comments
Taken on March 6, 2008


text:
track list
Album Live at Midnight
Label Fuel 2000 Records
Released June 15, 1999
This site contains content from artists, fans, and writers from around the internet in it's natural form. Such content is not representative of Viacom Media Networks.
©2017 Viacom International Inc. All Rights Reserved. MTV and all related titles and logos are trademarks of Viacom International Inc.


text:
1 Cor 12:10 (KJV)
I don't much like these discussions, but I happened to see your comment (#49) and noticed that you unfortunately picked discernment as a gift not included in the list in 1 Cor. As can be seen from the above quote, it is indeed included.
Where did I declare that XYZ person had this or that gift and WUV person did not have that gift?
In terms of my own giftings, I'm learning to not even acknowledge the truth about such things on FR.
I was blessed with a very anointed fellow from OKLAHOMA this week . . . way above average on humility as well as anointing and giftings in a list of ways. I got to spend probably 9 or more hours with him Thursday.
God has confirmed my walk with Him in a list of ways and again recently. His confirmation is sufficient.
Others, if they are determined to get wound up about such . . . can go . . . chase a duck, as mother used to say.
I believe you owe Quix an apology. He was not the one to say what you think, but he only included what OpusatFR said from post #40 and then responded to him, here is OpusatFR's post:
To: Quix
Even the professions own research has shown that a LOT of laymen, grandparents, etc. are great at helping others through emotional, mental, relationship problems somewhat on a par with highly educated professionals.
There is a vast difference between laymen helping others through emotional, mental, relationship problems somewhat, and a diagnosis of mental illness and its treatment.
You stated, Experienced pastors, deacons, elders and even laymen and women did quite well at discerning the difference between demon possession/oppression and mental illness
Thats absolute balony.
At any other time, I wouldnt bother replying to one of your posts. However, the idea that one can determine demon possession from mental illness simply from discernment by a layman needs to be trashed.
There is enough suffering from mental illness, especially untreated mental illness caused by biological problems without some ridiculous statement that anyone can tell who is demon possessed and who is sick.
That nasty bit of false piety and spiritual abuse had ended or so I thought.
40 posted on Friday, August 12, 2011 9:19:05 PM by OpusatFR


text: South Korea on Thursday slashed its economic growth forecast for this year to 2.3 percent, citing a continued slump in export markets and a weak Japanese yen. The new target was sharply down from a December estimate of 3.0 percent and below the central bank's revised forecast of 2.8 percent. "It's difficult to expect a meaningful pick-up in exports this year due to a slow recovery in global demand and the yen's weakness," the Ministry of Strategy and Finance in a statement. "Conditions are also weak for domestic consumption and corporate investment to improve in the near future." The ministry said the government would come up with a stimulus package, including a supplementary budget, to fund growth measures, including efforts to boost the property market. The additional spending will likely be funded by issuing new government debt, which may further delay the finance ministry's ambition of a fiscal surplus by next year. The government has already given up on returning the fiscal balance to a surplus this year, settling for a budget deficit equivalent to 0.3 percent of gross domestic product. Analysts said they expected the spending package would be between 10 trillion won ($9.0 billion) and 15 trillion won, and aimed at creating jobs and supporting low-income earners. The central Bank of Korea confirmed Tuesday that the economy grew just 2.0 percent last year -- the slowest rate for three years -- on weak export growth and consumer demand. South Korea's exporters have been hurt by the falling yen, which has weakened in recent months as the new government in Tokyo embarks on an aggressive monetary easing policy it says is aimed at kickstarting inflation. Finance Minister Hyun Oh-Seok said last week a policy mix aimed at reviving the economy could also include monetary steps, sparking speculation that the central bank may lower interest rates in the near future. Earlier this month, the bank kept its rate unchanged at 2.75 percent for a fifth consecutive month. The last time South Korea adopted a supplementary budget was in 2009 when it drew up 28.4 trillion won in additional spending in a bid to tide over the global financial crisis. -- Dow Jones Newswires contributed to this report --


text:
How the Grinch Stole Christmas! - Dr. Seuss
What parents need to know
Parents Need to Know
Parents need to know that How the Grinch Stole Christmas! is a digital version of the classic Dr. Seuss children's book, whose message teaches children that the true meaning of Christmas is found in peoples' hearts rather than in material trappings. The Grinch tries to stop Christmas by stealing all of the Whos' presents and decorations, but after the Whos begin to sing joyfully on Christmas morning anyway, the Grinch has an epiphany, returns the gifts, and joins in the celebration.
User reviews
Parents say
Kids say
Is it any good?
HOW THE GRINCH STOLE CHRISTMAS! offers many fun ways for kids to interact with the story digitally, but it's not the strongest Dr. Seuss app in the library. The male narrator's British accent is questionable, and the illustrations don't always change with each page turn, which affects the story's pacing. It's still a great app with a lot to offer, including the original illustrations from the book.
App details
|iPhone, iPod Touch, iPad, Android, Kindle Fire, Nook HD
|Release date:
|September 27, 2010
|Oceanhouse Media
|Minimum software requirements:
|iOS 4.3 or later; Android 2.1 and up
Great handpicked alternatives
Excellent ebook adaptation for the youngest readers.age 3+
Exceptional voice acting elevates great Seuss ebook.age 4+
Another children's classic smoothly transitions to digital.age 3+
Spectacular app redefines the concept of read-along books.age 4+
Interactive Dr. Seuss tale helps kids conquer fears.age 3+
Perfect adaptation of classic Dr. Seuss mischief-maker.age 4+
Heartwarming TV special is true to Seuss' classic book.age 4+
For kids who love Dr. Seuss and holidays
Browse more apps
What parents and kids say
A safe community is important to us. Please observe our guidelines
There aren't any reviews yet. Be the first to review this title.


text:
Emerging regions have robust collaborations, but need more researchers.
Researchers are in demand in east Asia, Latin America and southern Africa — regions not considered traditional scientific powerhouses — where doctoral-degree holders tend to leave academia for government or the private sector, says a report. CODOC — Cooperation on Doctoral Education Between Africa, Asia, Latin America and Europe, published on 4 October by the European University Association (EUA) in Brussels, examined international collaboration across fields at universities to assess efforts to build research capacity. It documents ample international collaboration at universities in east Asia and an increasing number in Brazil and Mexico, but notes the need for more research investment in southern Africa to expand such efforts. Thomas Jørgensen, head of the EUA's council for doctoral education and author of the report, says that increasing collaboration hasn't made it any easier to retain academic faculty members at universities in the three emerging regions. But early-career scientists who are willing to leave their home countries can find posts that match their research specialities, he says. "The need for early-stage researchers is desperately there," adds Jørgensen. - Naturejobs,
Nature 490,573(2012), 24 October 2012


text:
Tropical Fish Keeping - Aquarium fish care and resources (http://www.tropicalfishkeeping.com/forum.php)
- Fish Breeding (http://www.tropicalfishkeeping.com/fish-breeding/)
- - Baby Kribs! (http://www.tropicalfishkeeping.com/fish-breeding/baby-kribs-13830/)
Baby Kribs!
Hi all. I have some baby kribs in my tank (I count 6) and right now they are literally barely visible. Do I need to worry about finding some sort of baby food for them at this point? Or do they live off tiny aquarium stuff until they are a little bigger? Help and thanks. :o [/u]
Congratulations :D:D. im not sure what you should feed them, maybe your lfs has some fry food for your kribs, and maybe baby brine shrimp will work, not sure though ive only ever had livebearer babies lol. good luck:D
Congratulations gilfish! I would imaging that baby brine shrimp, liquifry or flakes crushed into a very fine power and fed with a pipette would be okay.
|All times are GMT -5. The time now is 10:00 AM.
Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2017, vBulletin Solutions, Inc.
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.


text:
Crawley named to deputy county manager position
She becomes second African-American appointed to post this year
Jane D. Crawley has been named Henrico's deputy county manager for community services, effective Sept. 8.
Crawley, who currently serves as director of the county's Department of Social Services, will succeed George T. Drumwright Jr., who is retiring after more than 34 years in the position. County Manager Virgil Hazelett announced the appointment today.
The move continues an increase in diversity among Henrico's top appointed and elected officials. Crawley becomes the second African-American appointed this year to serve as one of five deputy county managers, following Tim Foster, who is the deputy county manager for community operations.
The Board of Supervisors also includes two African-American members: longtime Fairfield District Supervisor Frank Thornton and newly elected Varina District Supervisor Tyrone Nelson, whose term began in January.
One more vacancy will occur in the county's senior leadership when Deputy County Manager for Special Services Angela Harper retires officially later this year.
As deputy county manager for community services, Crawley will have direct responsibilities over Henrico Area Mental Health and Developmental Services, Social Services, the Henrico County Health Department, the Juvenile Detention Home and James River Juvenile Detention Center, the Community Corrections program and the Capital Region Workforce Partnership — agencies with combined budgets of more than $65 million and nearly 600 employees. Her portfolio also includes county programs and services funded by the Virginia Juvenile Community Crime Control Act.
Crawley began her Henrico career in 1991 as a casework supervisor in Social Services. She also worked as the department's assistant director before being named director in January 2006.
A Richmond native, Crawley earned a bachelor's degree in social work from Norfolk State University and received a master's degree in public administration from Virginia Commonwealth University. She has served on the board of directors of Henrico Court Appointed Special Advocates and was appointed to the Virginia Child Fatality Review Team. She currently is a member of the Virginia League of Social Services Executives, the Child Welfare Advisory Committee and the Virginia Association of Local Human Services Administrators.
Villa's Flagler Housing wins national NAEH award
St. Joseph's Villa's Flagler Housing & Homeless Services was one of three entities to earn the National Alliance to End Homelessness' Champion of Change Award. The awards were presented Nov. 17 during a ceremony at the Newseum in Washington, D.C.
NAEH annually recognizes proven programs and significant achievements in ending child and family homelessness.
Flagler completed its transition from an on-campus shelter to the community-based model of rapid rehousing in 2013, and it was one of the nation's first rapid re-housing service providers to be certified by NAEH. > Read more.
RIR's Christmas tree lighting rescheduled for Dec. 12
Richmond International Raceway's 13th annual Community Christmas tree lighting has been rescheduled from Dec. 6 to Monday, Dec. 12, at 6:30 p.m., due to inclement weather expected on the original date.
Entertainment Dec. 12 will be provided by the Laburnum Elementary School choir and the Henrico High School Mighty Marching Warriors band. Tree decorations crafted by students from Laburnum Elementary School and L. Douglas Wilder Middle School will be on display. Hot chocolate and cookies will be supplied by the Henrico High School football boosters. > Read more.
Weekend Top 10
Given the warm weather lately, Saturday's RVA Polar Plunge Winter Fest, benefiting Special Olympics Virginia, might actually be enjoyable! Other weekend events you're sure to enjoy include the 14th annual Richmond Kids Expo at the Richmond Raceway Complex, the Richmond Symphony and The Taters in concert at The Cultural Arts Center at Glen Allen, and the Richmond Ballet Minds in Motion Team XXL performing at the Henrico Theatre. This is also the last weekend to check out HATTheatre's production of "Bill W. and Dr. Bob." For all our top picks this weekend, click here! > Read more.
ACLU urges McAuliffe to veto anti-immigration bills
Business in brief
Henrico to offer free workshop March 4 on outdoor improvements
Governor signs bills to fight Virginia's opioid crisis
New law lets concession stands sell cans of beer
- More News
Print Edition
Feb. 16, 2017Click here to read the print edition.
Weekend Top 10
Restaurant Watch
Weekend Top 10
American Tap Room at Willow Lawn closes
Weekend Top 10
- More Entertainment
Obituary – Anne Faudree Barker
Obituary – Jonathan "Bryan" Lawler
Obituary – Jean Harless
- More Obituaries
Villa's Flagler Housing wins national NAEH award
RIR's Christmas tree lighting rescheduled for Dec. 12
project:HOMES' 'Renew Crew' helps Henrico citizen
- More Community
Thanksgiving, Part II
Storm woes for e-junkies
'Good old days' were good – for some
- More Opinions
RIR to admit children 12 and younger free next year
Henrico teams win district, state championships
Varina HS to host Basketball Skill Development Academy June 20-23
- More Sports
|February 2017
Place an Ad | More Classifieds
CalendarThe Pocahontas Chapter of the Virginia Native Plant Society will meet at 7 p.m. at Lewis Ginter Botanical Garden. Berniece Thieblot will share the story of how her 600-acre property in Nelson County became a designated Virginia Treasure in 2016. Virginia Treasures are identified by the state to preserve, protect and highlight Virginia's most important ecological, cultural, scenic and recreational assets as well as its special lands. The program is free and open to the public. A short business meeting will follow the presentation. For details, visit http://www.vnps.org/pocahontas. Full text


text:
The GG&G Bolt On Aimpoint Micro Sight Mount with Integral Flip-Up Lens Covers is just what you need for installing an Aimpoint Micro on your flattop AR. The mount features a custom lens cover for the objective and an integral lens cover for the ocular. This unique item solves two problems by providing a solid mount and protection for your expensive optic.
GG&G Bolt On Aimpoint Micro Aimpoint Micro T-1, T-2, H-1 Sight Mount with Integral Flip-Up Lens Covers Picatinny-Style Matte
- Product Family #: 542312
- Product #: {{availableProducts[0].id}}
- {{availableProducts[0].vendor}} #: {{availableProducts[0].sku}}
- UPC #: {{availableProducts[0].upc}}
Product Information
The statements and opinions expressed within Customer Reviews reflect each author's personal perspective and do not imply endorsement by MidwayUSA, its Employees or any other organization. Customers should in no way infer that MidwayUSA has validated review information as safe, accurate or appropriate.


text: Watch a new episode of Bleach, tonight @ 12:00a/11:00c! Don't forget to tweet using the hashtag #bleach during the show! Bleach Episode 335 - Number 1519 Hiding in the Dangai? Ichigo is Alone?! Opening 14 - BLUE by ViViD Ending 28 - Haruka Kanata (Far Away) by UNLIMITS This week on Bleach... After being brought back to the Urahara Shop by Urahara, Ichigo heads into the Dangai to retrieve his Reishi. Last time on Bleach... Bleach. Only Toonami. SPOILERS ARE NOT TOLERATED. Please, no talks of future episodes, events, and etc! All spoilers must be taken to The Anime Forum or sent through PM! This talkback is ONLY about this episode and episodes that have aired on Adult Swim/Toonami.


text:
Wego.com.sg recently found 9 hotels in Los Alamos, United States. Book last minute hotel or find great hotel deals such as Hampton Inn - Suites Los Alamos for S$182 per night. Save more on cheap hotels with rates from as low as S$63 per night.
Filters help you save time when choosing where to stay. Try clicking on a few now...
Los Alamos Hotels 3 Star Hotels Los Alamos Cheap Hotels Los Alamos Cheap Accommodation Los Alamos
Flights to United States Flights from United States United States Airports United States Airlines


text:
Research Topics
Genomes and Genes
Gene Symbol: BUB1
Description: BUB1 mitotic checkpoint serine/threonine kinase
Alias: BUB1A, BUB1L, hBUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog, BUB1, mitotic checkpoint serine/threonine kinase, budding uninhibited by benzimidazoles 1 homolog, mitotic spindle checkpoint kinase
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications162 found, 100 shown here
- Two histone marks establish the inner centromere and chromosome bi-orientationYuya Yamagishi
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
Science 330:239-43. 2010..Here, we show that the phosphorylation of histone H3-threonine 3 (H3-pT3) mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 (H2A-S121) phosphorylation in targeting the CPC to the inner centromere in fission ..
- A dual role for Bub1 in the spindle checkpoint and chromosome congressionPatrick Meraldi
Department of Biology and Biological Engineering, MIT, Cambridge, MA 02139 4307, USA
EMBO J 24:1621-33. 2005..In this study, we use live-cell imaging coupled with RNA interference to investigate the functions of human Bub1. We find that Bub1 is essential for checkpoint control and for correct chromosome congression...
- Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancerGennadi V Glinsky
Sidney Kimmel Cancer Center, San Diego, California 92121, USA
J Clin Invest 115:1503-21. 2005....
- Bub1 regulates chromosome segregation in a kinetochore-independent mannerChristiane Klebig
Institute of Biochemistry, Eidgenossische Technische Hochschule ETH Zurich, 8093 Zurich, Switzerland
J Cell Biol 185:841-58. 2009The kinetochore-bound protein kinase Bub1 performs two crucial functions during mitosis: it is essential for spindle checkpoint signaling and for correct chromosome alignment...
- Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosisZhanyun Tang
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
Proc Natl Acad Sci U S A 101:18012-7. 2004..Here, we report that Bub1 retains centromeric cohesion in mitosis of human cells...
- Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1Tomomi Kiyomitsu
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Dev Cell 13:663-76. 2007..AF15q14/blinkin, a member of the Spc105/Spc7/KNL-1 family, directly links spindle checkpoint proteins BubR1 and Bub1 to kinetochores and is required for spindle checkpoint and chromosome alignment...
- Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congressionVictoria L Johnson
School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
J Cell Sci 117:1577-89. 2004..The protein kinase Bub1 localizes to the kinetochore very early during mitosis, followed by Cenp-F, BubR1, Cenp-E and finally Mad2...
- Bub1 maintains centromeric cohesion by activation of the spindle checkpointDavid Perera
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
Dev Cell 13:566-79. 2007b>Bub1 is a component of the spindle assembly checkpoint (SAC), a surveillance mechanism that ensures genome stability by delaying anaphase until all the chromosomes are stably attached to spindle microtubules via their kinetochores...
- The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochoresVictor M Bolanos-Garcia
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
Structure 17:105-16. 2009The interaction of the central mitotic checkpoint component BUB1 with the mitotic kinetochore protein Blinkin is required for the kinetochore localization and function of BUB1 in the mitotic spindle assembly checkpoint, the regulatory ..
- Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationRobin M Ricke
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Cell Biol 193:1049-64. 2011High expression of the protein kinase Bub1 has been observed in a variety of human tumors and often correlates with poor clinical prognosis, but its molecular and cellular consequences and role in tumorigenesis are unknown...
- Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpointZhanyun Tang
Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Mol Cell 16:387-97. 2004..Here we show that HeLa cells depleted for Bub1 by RNA interference are defective in checkpoint signaling...
- Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cellsS S Taylor
School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
J Cell Sci 114:4385-95. 2001b>BUB1 is a budding yeast gene required to ensure that progression through mitosis is coupled to correct spindle assembly...
- Structure and substrate recruitment of the human spindle checkpoint kinase Bub1Jungseog Kang
Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Mol Cell 32:394-405. 2008..The checkpoint kinase Bub1 contributes to checkpoint sensitivity through phosphorylating the APC/C activator, Cdc20, and inhibiting APC/C ..
- Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibitionSheena D'Arcy
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
J Biol Chem 285:14764-76. 2010..structure reveals divergence from the classical TPR fold and is highly similar to the TPR domain of budding yeast Bub1. Shared distinctive features include a disordered loop insertion, a 3(10)-helix, a tight turn involving glycine ..
- Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1Tomomi Kiyomitsu
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Mol Cell Biol 31:998-1011. 2011..Here, we report distinct and essential binding domains for Bub1 and BubR1 (here designated Bubs) at the N terminus of blinkin and for Zwint-1 and hMis14/hNsl1 at the C terminus...
- Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20Christopher J Morrow
Faculty of Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
J Cell Sci 118:3639-52. 2005..Several other protein kinases, including Bub1 and members of the Ipl1/aurora family, also regulate anaphase onset...
- A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766TPaula M Hempen
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
Hum Mutat 21:445. 2003To determine sequence variations of the BUB1 and BUB1B genes in pancreatic cancer, the entire coding regions of the BUB1 and BUB1B genes were sequenced in pancreatic cancer cell lines and xenografts...
- KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosomeWei Qi
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
J Biol Chem 282:3672-9. 2007..b>Bub1 is a protein serine-threonine kinase that plays multiple roles in chromosome segregation and the spindle checkpoint...
- Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1Jeroen Pouwels
Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland
Cell Cycle 6:1579-85. 2007..Furthermore our studies implicate Sgo1 in the tension sensing mechanism of the spindle checkpoint by regulating Plk1 kinetochore affinity...
- Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survivalMasayoshi Shichiri
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo 113 8519, Japan
Cancer Res 62:13-7. 2002Sequence alterations of mitotic checkpoint genes, hBUB1 and hBUBR1, were examined, and their gene transcripts were quantified using on-line, real-time quantitative reverse transcription-PCR in surgically resected human colorectal cancers ..
- BUB1 mediation of caspase-independent mitotic death determines cell fateYohei Niikura
Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Cell Biol 178:283-96. 2007..In BUB1-deficient (but not MAD2-deficient) cells, conditions that activate the spindle checkpoint (i.e...
- Mutations of mitotic checkpoint genes in human cancersD P Cahill
The Johns Hopkins Oncology Center, Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 392:300-3. 1998..The normal mitotic checkpoints of cells displaying microsatellite instability become defective upon transfer of mutant hBUB1 alleles from either of two CIN cancers.
- The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinaseS S Taylor
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Biol 142:1-11. 1998..Previously, we showed that the murine homologue of Bub1 is not only required for checkpoint response to spindle damage, but also restrains progression through a normal ..
- A role for the Adenomatous Polyposis Coli protein in chromosome segregationK B Kaplan
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Cell Biol 3:429-32. 2001..APC localizes to the ends of microtubules embedded in kinetochores and forms a complex with the checkpoint proteins Bub1 and Bub3. In vitro, APC is a high-affinity substrate for Bub kinases...
- The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosisS A Jablonski
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Chromosoma 107:386-96. 1998..Human cells contain two related protein kinases, hBUB1 and hBUBR1, that appear to have evolved from a single ancestral BUB1 gene...
- Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus-their association with aneuploidy and neoplastic progressionShareen H Doak
Human Molecular Pathology Group, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
Mutat Res 547:133-44. 2004..Gene expression levels of the MAD2 and BUB1 mitotic spindle checkpoint genes were assessed in 37 Barrett's patients (with histology ranging from metaplasia to ..
- Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localizationTomoya S Kitajima
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
Curr Biol 15:353-9. 2005..In fission yeast, Sgo localization depends on Bub1, a conserved spindle checkpoint protein, which is enigmatically also required for chromosome congression during ..
- Surveillance mechanism linking Bub1 loss to the p53 pathwayOle V Gjoerup
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 104:8334-9. 2007b>Bub1 is a kinase believed to function primarily in the mitotic spindle checkpoint. Mutation or aberrant Bub1 expression is associated with chromosomal instability, aneuploidy, and human cancer...
- The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteinsX Wang
Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 276:26559-67. 2001..Here we report that the two known binding partners of hBUB3, the mitotic checkpoint proteins hBUB1 and hBUBR1, both carry a region with remarkable similarity to the GLEBS motif of hNUP98...
- Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancerR G Jaffrey
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Scotland
Cancer Res 60:4349-52. 2000..Mutations in the mitotic spindle checkpoint kinase BLUB1 cause a dominant negative disruption of the spindle, leading to chromosome instability in ..
- Characterization of the tetratricopeptide-containing domain of BUB1, BUBR1, and PP5 proves that domain amphiphilicity over amino acid sequence specificity governs protein adsorption and interfacial activitySylvie Beaufils
Department of Biochemistry, University of Cambridge, Cambridge, UK
J Phys Chem B 112:7984-91. 2008..The N-terminal region of BUB1, BUBR1, and protein phosphatase 5 (PP5) contains tandem arrangements of the TPR motif...
- hBUB1 defects in leukemia and lymphoma cellsHon Yu Ru
Institute of Medical Science, Tzu Chi University, Hualien, Taiwan, Republic of China
Oncogene 21:4673-9. 2002..In some colorectal cancers with CIN it was found to have hBUB1 gene mutated and the mutated gene functions dominantly...
- Characterization of MAD2B and other mitotic spindle checkpoint genesD P Cahill
Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21231, USA
Genomics 58:181-7. 1999..In addition, we resolved the genomic intron-exon structure of the human BUB1 gene. We then searched for mutations in these genes in a panel of 19 aneuploid colorectal tumors...
- Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturationM S Schwab
Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado, School of Medicine, 4200 East Ninth Ave, Denver, CO 80262, USA
Curr Biol 11:141-50. 2001..In yeast, the serine/threonine protein kinase Bub1 and the WD-repeat protein Bub3 are elements of a signal transduction cascade that regulates the kinetochore ..
- The function of a spindle checkpoint gene bub-1 in C. elegans developmentXiangming Wang
School of Life Sciences, Peking University, Beijing, China
PLoS ONE 4:e5912. 2009The serine/threonine kinase BUB1 (Budding Uninhibited by Benzimidazole 1) was originally identified in yeast as a checkpoint protein, based on its mutant's incapacity of delaying the cell cycle in response to loss of microtubules...
- A screen for dynein synthetic lethals in Aspergillus nidulans identifies spindle assembly checkpoint genes and other genes involved in mitosisV P Efimov
Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
Genetics 149:101-16. 1998..nidulans autonomously replicating vector. Sequencing revealed homology to the spindle assembly checkpoint genes BUB1 and BUB3 from Saccharomyces cerevisiae...
- mei-41 and bub1 block mitosis at two distinct steps in response to incomplete DNA replication in Drosophila embryosM Garner
Molecular, Cellular, and Developmental Biology, University of Colorado, 80309, Boulder, CO, USA
Curr Biol 11:1595-9. 2001..We find that mitotic cyclins are stabilized and that a spindle checkpoint protein, Bub1, localizes onto chromosomes during mitotic arrest in dup mutants...
- Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigensJingwei Cheng
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Semin Cancer Biol 19:218-28. 2009..SV40 LT also binds to several additional cellular proteins including p300, CBP, Cul7, IRS1, Bub1, Nbs1 and Fbxw7 that contribute to viral transformation...
- Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeastYusuke Toyoda
Department of Gene Mechanisms, Graduate School of Biostudies, 606 8502, Kyoto, Japan
Curr Biol 12:347-58. 2002..The failure to form cohesion in the S phase results in premature separation of chromatids in G2/M. Mitotic kinetochores free from microtubules or the lack of tension are known to activate spindle checkpoint...
- Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinomaDemetrius M Kokkinakis
Department of Pathology, University of Pittsburgh, PA 15213 1863, USA
Mol Cancer Ther 4:1338-48. 2005..of NF2, ETS2, CLU, GADD45alpha, GADD45beta, and GADD45gamma and down-regulation of AURKB, TOP2A, CCNA, CCNB, PRC1, BUB1, NuSAP, IFI16, and BRCA1...
- Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochoresBingyi Xiao
Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Virol 84:9718-32. 2010..Moreover, LANA associated with another kinetochore protein, Bub1 (budding uninhibited by benzimidazole 1), which is known to form a complex with CENP-F...
- Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tensionKatie B Shannon
SPIRE fellow, Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
Mol Biol Cell 13:3706-19. 2002..decrease in tension at 23 degrees C, and metaphase kinetochores at 23 degrees C exhibited higher levels of 3F3/2, Bub1, and BubR1 compared with 37 degrees C...
- The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivoJomon Joseph
National Institutes of Health, National Institute of Child Health and Human Development, Building 18, Room 106, 18 Library Drive, MSC 5431, Bethesda, MD 20892, USA
Curr Biol 14:611-7. 2004..No similar disruption was observed after ablation of proteins nonessential for MT-kinetochore interactions (CENP-I, Bub1, CENP-E )...
- Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatinApril R Robbins
Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
Cell Cycle 4:717-26. 2005..Decreased amounts of hBUB1, CENP-F and the motor protein CENP-E were present on kinetochores of treated cells...
- Genetic evidence for a role of phospholipase C at the budding yeast kinetochoreN DeLillo
Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaicam New York, NY 11439, USA
Mol Genet Genomics 269:261-70. 2003..However, plc1Delta cells require a functional BUB1/BUB3-dependent spindle checkpoint for viability...
- Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)Gustavo Delhon
Plum Island Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Greenport, New York 11944, USA
J Virol 80:8439-49. 2006....
- Sequence analysis of two cosmids from Schizosaccharomyces pombe chromosome IIIM Lucas
Institut National Agronomique, Laboratoire de Genetique Moleculaire et Cellulaire, INRA, CNRS, Centre de Biotechnologies Agro Industrielles, 78850 Thiverval Grignon, France
Yeast 16:1519-26. 2000..gms1 on SPCC895, encoding the mating type P-factor precursor and an UDP-galactose transporter, respectively, and bub1 and ade6 in SPCC1322, encoding a protein kinase and a phosphoribosylaminoimidazole carboxylase, respectively...
- Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progressionErwan Watrin
Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
Curr Biol 16:863-74. 2006..Mutation of Scc2 orthologs causes defects in cohesion, transcription, and development, resulting in Cornelia de Lange syndrome in humans...
- Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpointRey Huei Chen
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
EMBO J 23:3113-21. 2004..The protein kinase Bub1 is an essential checkpoint component that resides at kinetochores during mitosis...
- Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigenSergei Boichuk
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
J Virol 84:8007-20. 2010..the hallmarks of a cellular DNA damage response (DDR), such as focal accumulation of gamma-H2AX and 53BP1, via Bub1 binding. Here we expand our characterization of LT effects on the DDR...
- Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cellsElsa Logarinho
Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
J Cell Sci 117:1757-71. 2004..Here, we analyse how the kinetochore localization of the Drosophila spindle checkpoint proteins Bub1, Mad2, Bub3 and BubR1, behave in response to alterations in microtubule binding or tension...
- Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APCG K Chan
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Cell Biol 146:941-54. 1999Human cells express two kinases that are related to the yeast mitotic checkpoint kinase BUB1. hBUB1 and hBUBR1 bind to kinetochores where they are postulated to be components of the mitotic checkpoint that monitors kinetochore activities ..
- The multiple roles of Bub1 in chromosome segregation during mitosis and meiosisFrancesco Marchetti
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Cell Cycle 9:58-63. 2010..Among the SAC proteins, the budding uninhibited by benzimidazole protein 1 (Bub1), is a highly conserved protein of prominent importance for the proper functioning of the SAC...
- Loading of the 3F3/2 antigen onto kinetochores is dependent on the ordered assembly of the spindle checkpoint proteinsOi Kwan Wong
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
Mol Biol Cell 17:4390-9. 2006..attachment or of tension across sister kinetochores through phosphorylation of kinetochore proteins by the Mps1, Bub1, BubR1, Aurora B, and Plk1/Plx1 kinases...
- BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1Rey Huei Chen
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
J Cell Biol 158:487-96. 2002..Unattached kinetochores associate with several checkpoint proteins, including BubR1, Bub1, Bub3, Mad1, Mad2, and CENP-E...
- Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1G K Chan
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Cell Biol 143:49-63. 1998..screen to isolate interacting proteins that included the kinetochore proteins CENP-E, CENP-F, and hBUBR1, a BUB1-related kinase that was found to be mutated in some colorectal carcinomas (Cahill, D.P., C. Lengauer, J. Yu, G.J...
- The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint functionSheila Kadura
Verna and Marrs McClean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Biol Cell 16:385-95. 2005..to isolate SAC mutants in fission yeast yielded point mutations in three fission yeast SAC genes: mad1, bub3, and bub1. The bub1-A78V mutant is of particular interest because it produces a wild-type amount of protein that is mutated ..
- Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindlesShigeaki Saitoh
Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka 839 0864, Japan
Mol Biol Cell 16:3666-77. 2005..During early mitosis, the spindle checkpoint proteins, such as Mad2 and Bub1, accumulate at kinetochores that do not associate with the spindle...
- Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochoresR Fraschini
Dipartimento di Biotecnologie e Bioscienze, Piazza della Scienza 2, 20126 Milano, Italy
EMBO J 20:6648-59. 2001The kinetochore checkpoint pathway, involving the Mad1, Mad2, Mad3, Bub1, Bub3 and Mps1 proteins, prevents anaphase entry and mitotic exit by inhibiting the anaphase promoting complex activator Cdc20 in response to monopolar attachment of ..
- Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteinsYong Zhao
Graduate Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
Curr Biol 16:1764-9. 2006..activate the spindle checkpoint by recruiting several spindle-checkpoint proteins, including Mps1, Mad1, Mad2, Bub1, Bub3, and BubR1 (Mad3 in yeast)...
- Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complexEulalie Buffin
Centre National de la Recherche Scientifique, Centre de Genetique Moleculaire, Avenue de la Terrasse, 91198 Gif sur Yvette, France
Curr Biol 15:856-61. 2005..Moreover, Mad2, but not BubR1, Bub1, Bub3, or Mps1, requires Rod/Zw10 for its accumulation on unattached kinetochores...
- Isolation and characterization of a Paramecium cDNA clone encoding a putative serine/threonine protein kinaseSatoru Wada
Graduate School of Life Sciences, Tohoku University, Aoba Aramaki, Sendai 980 8578, Japan
Genetica 131:307-14. 2007..Comparisons of expression level have shown that pcstk1 is expressed equally in cells at different stages (sexual and asexual). We discussed the possibility, as in other organisms, that a family of MAP kinase genes exists in P. caudatum...
- Cloning and characterization of an acyl-CoA-dependent diacylglycerol acyltransferase 1 (DGAT1) gene from Tropaeolum majus, and a study of the functional motifs of the DGAT protein using site-directed mutagenesis to modify enzyme activity and oil contentJingyu Xu
National Research Council of Canada, Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, Canada
Plant Biotechnol J 6:799-818. 2008..Thus, alteration of this putative serine/threonine protein kinase site can be exploited to enhance DGAT1 activity, and expression of mutated DGAT1 can be used to enhance oil content...
- TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cellsMijin Kim
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Cancer Res 68:3440-9. 2008..of TRAIL to either nocodazole or paclitaxel (Taxol) reduced levels of the mitotic checkpoint proteins BubR1 and Bub1. BubR1 mutated for the caspase cleavage sites, but not wild-type BubR1, was resistant to cleavage induced by TRAIL ..
- Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochoresSong Tao Liu
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Mol Biol Cell 14:1638-51. 2003..hMPS1 is required for MAD1, MAD2 but not hBUB1, hBUBR1 and hROD to bind to kinetochores...
- Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in miceKuo Tai Yang
Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan
Mol Biol Cell 21:2371-83. 2010..Furthermore, AurC-KD reduced Aurora-C and histone H3 phosphorylation and inhibited kinetochore localization of Bub1 and BubR1...
- Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeastK G Hardwick
Department of Physiology, University of California, San Francisco 94143 0444, USA
J Cell Biol 131:709-20. 1995..assembly checkpoint mutants reveals that this response to microtubule-disrupting agents is defective in some (mad2, bub1, and bub3) but not all (mad3, bub2) mutant strains...
- Pericentromeric regions containing 1.688 satellite DNA sequences show anti-kinetochore antibody staining in prometaphase chromosomes of Drosophila melanogasterJ P Abad
Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
Mol Gen Genet 264:371-7. 2000..Immunostaining of prometaphase chromosomes with the kinetocore-specific anti-BUB1 antibody reveals the transient presence of this centromeric protein in all the regions containing the 1...
- Bub1 up-regulation and hyperphosphorylation promote malignant transformation in SV40 tag-induced transgenic mouse modelsConghui Guo
Department of Surgery, University of Western Ontario, London, Ontario, Canada
Mol Cancer Res 4:957-69. 2006..In particular, the spindle checkpoint component Bub1 was persistently up-regulated from early to advanced androgen-independent prostate cancer lesions...
- Cloning and expression analyses of sucrose non-fermenting-1-related kinase 1 (SnRK1b) gene during development of sorghum and maize endosperm and its implicated role in sugar-to-starch metabolic transitionMukesh Jain
Department of Plant Pathology, University of Florida, Gainesville, FL 32611 0680, USA
Physiol Plant 134:161-73. 2008..seed development. However, discordant in situ hybridization and immunolocalization data indicated that the expression of SbSnRK1b homologue in maize is under posttranscriptional control during endosperm development...
- Novel interactors and a role for supervillin in early cytokinesisTara C Smith
Department of Cell Biology and Cell Dynamics Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Cytoskeleton (Hoboken) 67:346-64. 2010..The interacting sequences from 12 of these proteins (BUB1, EPLIN/LIMA1, FLNA, HAX1, KIF14, KIFC3, MIF4GD/SLIP1, ODF2/Cenexin, RHAMM, STARD9/KIF16A, Tks5/SH3PXD2A, TNFAIP1) ..
- Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsD A Skoufias
Institut de Biologie Structurale J P Ebel Commissariat à l Energie Atomique Centre National de la Recherche Scientifique, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
Proc Natl Acad Sci U S A 98:4492-7. 2001..A number of proteins, including mad2, bub1, and bubR1, have been implicated in the metaphase checkpoint control in mammalian cells...
- The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiaeS Bidlingmaier
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
Mol Cell Biol 21:2449-62. 2001..Many Cbk1-related kinases have been shown to regulate cellular morphology...
- Distinct chromosome segregation roles for spindle checkpoint proteinsCheryl D Warren
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Biol Cell 13:3029-41. 2002..Loss of Bub1 or Bub3 protein elicits the largest effect. Analysis of Bub1p reveals the presence of two molecular functions...
- The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytesChizuko Tsurumi
Max Planck Institut fuer Immunbiologie, Developmental Biology, Freiburg, Germany
J Cell Biol 167:1037-50. 2004In Xenopus oocytes, the spindle assembly checkpoint (SAC) kinase Bub1 is required for cytostatic factor (CSF)-induced metaphase arrest in meiosis II...
- Disruption of astral microtubule contact with the cell cortex activates a Bub1, Bub3, and Mad3-dependent checkpoint in fission yeastSylvie Tournier
Division of Yeast Genetics, National Institute for Medical Research, London NW7 1AA, United Kingdom
Mol Biol Cell 15:3345-56. 2004..By analyzing the timing of kinetochore separation, we find that this anaphase delay requires the Bub3, Mad3, and Bub1 but not the Mad1 or Mad2 spindle assembly checkpoint proteins...
- Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ miceEiram Elahi
Colorectal Cancer Genetics, Institute for Cell and Molecular Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
PLoS ONE 4:e4388. 2009..functional polymorphisms that are involved in spindle checkpoint and chromosomal stability (Bub1b, Casc5, and Bub1), DNA repair (Recc1 and Prkdc) or inflammation (Duox2, Itgb2l and Cxcl5)...
- Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomesPatricia E Rischitor
The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 2:e1342. 2007..Checkpoint models propose that Mad1 and Bub1 act as stable kinetochore-bound scaffolds, to enhance recruitment of Mad2 and Mad3/BubR1, but this remains untested ..
- Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochoresJakub K Famulski
Department of Oncology, University of Alberta, Edmonton, Alberta T6G 1Z2, Canada
Curr Biol 17:2143-9. 2007..of tension, but not in the absence of kinetochore-microtubule attachments, results in the loss of hZW10, hROD, and hBub1 from kinetochores...
- Metaphase arrest with centromere separation in polo mutants of DrosophilaM M Donaldson
Cancer Research Campaign Cell Cycle Genetics Research Group, Department of Anatomy and Physiology, University of Dundee, Dundee DD1 4HN, Scotland
J Cell Biol 153:663-76. 2001..The point of arrest corresponds to the spindle integrity checkpoint; Bub1 protein and the 3F3/2 epitope are present on the separated kinetochores and the arrest is suppressed by a bub1 ..
- Kaposi's sarcoma-associated herpesvirus-encoded LANA can induce chromosomal instability through targeted degradation of the mitotic checkpoint kinase Bub1Zhiguo Sun
Department of Microbiology and Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Virol 88:7367-78. 2014..of micronuclei and multinucleation through its interaction with one of the critical spindle checkpoint proteins, Bub1, and the resulting degradation of Bub1...
- Minireview: branded from the start-distinct oncogenic initiating events may determine tumor fate in the thyroidJames A Fagin
Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0547, USA
Mol Endocrinol 16:903-11. 2002..Mutations of Bub1 or BubR1, genes coding for kinases involved in mitotic spindle assembly checkpoint signaling, are found in a small ..
- Genomic instability and colon cancerWilliam M Grady
Vanderbilt University Medical Center, 1161 21st Ave South, C2104 MCN, Nashville, TN 37232 2279, USA
Cancer Metastasis Rev 23:11-27. 2004..These studies have revealed mutation of the mitotic checkpoint regulators BUB1 and BUBR1 and amplification of STK15 in a subset of CIN colon cancers...
- Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanismsJennifer L McCulley
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 107:11465-70. 2010..Although we found the aneuploidy in the tel1 mec1 diploids mimicked that observed in bub1 diploids, the tel1 mec1 diploids had a functional spindle assembly checkpoint...
- Dual regulation of Mad2 localization on kinetochores by Bub1 and Dam1/DASH that ensure proper spindle interactionShigeaki Saitoh
Division of Cell Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka 839 0864, Japan
Mol Biol Cell 19:3885-97. 2008..in fission yeast is regulated by two partially overlapping but distinct pathways: the Dam1/DASH and the Bub1 pathways. We show that Mad2 is localized on "unattached" as well as "tensionless" kinetochores...
- Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosisJohn R Daum
Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Curr Biol 19:1467-72. 2009..Ska3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores. Ska3 protein accumulation at kinetochores in prometaphase is dependent on Sgo1 protein...
- Temporal and spatial regulation of targeting aurora B to the inner centromereY Watanabe
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
Cold Spring Harb Symp Quant Biol 75:419-23. 2010..Moreover, the phosphorylation of histone H3 threonine 3 (H3-pT3) mediated by Haspin cooperates with Bub1-mediated H2A-S121 phosphorylation in targeting the CPC to the inner centromere...
- Kinetochore-microtubule interactions "in check" by Bub1, Bub3 and BubR1: The dual task of attaching and signallingElsa Logarinho
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
Cell Cycle 7:1763-8. 2008..However, independent studies from many groups have interestingly found that the bone-a-fide Bub1, BubR1 and Bub3 SAC proteins are themselves required for proper kinetochoremicrotubule (K-MT) interactions...
- The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinaseSaskia J E Suijkerbuijk
Molecular Cancer Research and Cancer Genomics Centre, Department of Medical Oncology, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Dev Cell 22:1321-9. 2012Chromosomal stability is safeguarded by a mitotic checkpoint, of which BUB1 and Mad3/BUBR1 are core components. These paralogs have similar, but not identical, domain organization...
- The future of RIP2/RICK/CARDIAK as a biomarker of the inflammatory response to infectionMichelle L McCully
Departments of Microbiology and Immunology and Medicine, The FOCIS Centre for Clinical Immunology and Immunotherapeutics, Robarts Research Institute, The University of Western Ontario, Ontario, Canada N6A 5K8
Expert Rev Mol Diagn 8:257-61. 2008....
- Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation developmentD Wells
Department of Obstetrics and Gynecology, Yale University Medical School, New Haven, CT 06520, USA
Hum Reprod 20:1339-48. 2005..Appropriate gene expression is vital for the regulation of developmental processes. Despite this fact there is a remarkable paucity of information concerning gene activity during preimplantation development...
- A novel germline mutation of the LKB1 gene in a patient with Peutz-Jeghers syndrome with early-onset gastric cancerMasanobu Takahashi
Department of Clinical Oncology, Institute of Development, Aging and Cancer, and Tohoku University Hospital, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
J Gastroenterol 39:1210-4. 2004....
- The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylationLuying Jia
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Nat Commun 7:10818. 2016..It is unclear whether MCC suffices to inhibit all cellular APC/C. Here we show that human checkpoint kinase Bub1 not only directly phosphorylates Cdc20, but also scaffolds Plk1-mediated phosphorylation of Cdc20...
- BUB1 mRNA is significantly co-expressed with AURKA and AURKB mRNA in advanced-stage ovarian serous carcinomaBen Davidson
Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, N 0424, Oslo, Norway
Virchows Arch 464:701-7. 2014..the expression and clinical role of the spindle checkpoint kinase budding uninhibited by benzimidazole 1 (Bub1) in primary and metastatic advanced-stage ovarian serous carcinoma...
- Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signalingJohn Maciejowski
Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Cell Biol 190:89-100. 2010..e., before the appearance of functional kinetochores. Furthermore, intramitotic Mps1 inhibition evicted Bub1 and all other known SAC transducers from the outer kinetochore, but contrary to a recent study, did not perturb ..
- Intrakinetochore localization and essential functional domains of Drosophila Spc105Ralf B Schittenhelm
Institute of Zoology, University of Zurich, Zurich, Switzerland
EMBO J 28:2374-86. 2009..protein, which can bind to the Mis12/MIND and Ndc80 complexes and to the spindle assembly checkpoint components Bub1 and BubR1...
- Suppression of genomic instabilities caused by chromosome mis-segregation: a perspective from studying BubR1 and Sgo1Wei Dai
Department of Environmental Medicine and Pharmacology, New York University Langone Medical Center, Tuxedo, New York, USA
J Formos Med Assoc 108:904-11. 2009..During the past decade, we have carried out extensive investigation of the role of BubR1 (Bub1-related kinase) and Sgo1 (shugoshin 1), two important gene products that safeguard accurate chromosome segregation ..
- Kinetochore KMN network gene CASC5 mutated in primary microcephalyAnne Genin
Institute of Interdisciplinary Research IRIBHM, Universite Libre de Bruxelles, Anderlecht, Belgium
Hum Mol Genet 21:5306-17. 2012..Like MCPH gene ASPM, CASC5 is upregulated in the ventricular zone (VZ) of the human fetal brain. CASC5 binds BUB1, BUBR1, ZWINT-1 and interestingly it binds to MIS12 through a protein domain which is truncated by the mutation...
- Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancerA Gemma
Fourth Department of Internal Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Genes Chromosomes Cancer 29:213-8. 2000..genomic DNA sequence of 30 human lung cancer cell lines and 30 primary lung cancer tumors for a mutation in the hBUB1 mitotic checkpoint gene...
- Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosisDina Dikovskaya
Division of Cell and Developmental Biology, University of Dundee, Dundee DD1 5EH, Scotland, UK
J Cell Biol 176:183-95. 2007..This is accompanied by a decrease in the association of the checkpoint proteins Bub1 and BubR1 with kinetochores. Additionally, APC depletion reduced apoptosis...
Research Grants32
- Kinetochore Function and Cell Cycle Progression RevisionKatsumi Kitagawa; Fiscal Year: 2012..In Aim 2, we will investigate how Bub1 (a spindle checkpoint kinase) controls Sgo1 (Shugoshin, a tension sensor at the kinetochore)...
- CELL AND TUMOR GENETICS OF MITOTIC ARREST CHECKPOINTSPETER KARL SORGER; Fiscal Year: 2010..and Bub proteins to kinetochores will be studied, with particular emphasis on the members of the Ndc80 complex (4) Bub1, a kinase with dual functions in checkpoint control and chromosome-microtubule attachment will be analyzed using ..
- Structure and Function of a Eukaryotic CentromereKerry S Bloom; Fiscal Year: 2013..the barrel contributes to the regulatory function of the inner centromere and the spindle checkpoint, including the Bub1 kinase...
- PTEN Deficiency and Tumor DevelopmentYuxin Yin; Fiscal Year: 2012..Of significant interest was our finding that the levels of Bub1 and aurora B which are two critical mitotic checkpoint regulators are reduced in Pten null cells...
- BUB1 in Chromosomal Instability and TumorigenesisJan M van Deursen; Fiscal Year: 2013..b>Bub1, a mitotic checkpoint gene encoding a multi-functional serine/threonine protein kinase, has emerged as a prominent ..
- Mitotic Checkpoint Regulators: Roles in Development and CancerWilliam F Marzluff; Fiscal Year: 2010..Specifically, prompted by the identification of Bub1 mutations in certain colon cancer cell lines, in vitro studies have shown that interference with this mitotic ..
- Mechanisms of Mitotic Activation of the ATM kinaseSankar Mitra; Fiscal Year: 2013..depth studies have found that Aurora-B associated with ATM during mitosis and ATM was required for the activity of Bub1. Further we found that ATM phosphorylated Bub1 (at Ser314) and Mad 1(at Ser214)...
- MOLECULAR ANALYSIS OF CHROMOSOME SEGREGATION IN YEASTClarence Chan; Fiscal Year: 1999..They turned out to be: TUB3 and TUB1 (the alpha subunit of tubulin), CIN8 (one of 2 yeast kinesins), and BUB1 (one subunit of a checkpoint kinase)...
- Genome Persistence of KSHVErle S Robertson; Fiscal Year: 2013..We have also shown an association with the nuclear mitosis apparatus protein NuMA, as well as Bub1 and a number of CenP proteins...
- Role of Bub1 in SV40 large T antigen mediated transformation and replicationOle Gjoerup; Fiscal Year: 2011..We have identified an interaction of LT with the mitotic regulator Bub1. Bub1 is critical for preserving genome integrity...
- Mitotic Checkpoint Proteins in TumorigenesisFrank McKeon; Fiscal Year: 2006..abnormal chromosome segregation are killed in a manner dependent on signaling from two mitotic checkpoint proteins, BUB1 and MAD3L, to the tumor suppressor p53...
- Regulation of the Spindle Checkpoint Protein Bub1pYANIRA GONZALEZ; Fiscal Year: 2009..Interestingly, our lab has identified a mutation in the Mad3-like region (bub1-A78V) of the essential protein kinase Bublp that disrupts the nuclear and kinetochore localization of Bublp, BubSp ..
- Functional Analysis of Mitotic Checkpoint Gene Bub1bRakesh Goorha; Fiscal Year: 2005..The murine homologue (Bub1b) of the yeast mitotic checkpoint protein Bub1 was discovered by the principal investigator and shown to be expressed in a cell cycle-specific manner...
- The role of hBUB1-p53 pathway in genomic stability.Sam Thiagalingam; Fiscal Year: 2007..Unexpectedly, the second putative kinase isolated in the screen is hBUB1. BUB1 was originally isolated as a spindle assembly checkpoint gene in yeast and harbors mutations in a subset of ..
- Identification of Anticancer Drug TargetsRobert Wilson; Fiscal Year: 2004..of genes that bring about synthetic lethality represent potential drug targets for cancers with mutations in hBUB1 or hMSH2...
- STRUCTURE AND FUNCTION OF MITOTIC CHECKPOINT PROTEINSDavid Wilson; Fiscal Year: 2002..on an essential element in the Saccharomyces cerevisiae checkpoint, Bub3, its structure and interaction with Bub1, a Bub3 kinase...
- IDENTIFICATION OF ANTICANCER DRUG TARGETS USING YEASTRobert Wilson; Fiscal Year: 2001..of genes that bring about synthetic lethality represent potential drug targets for cancers with mutations in hBUB1 or hMSH2...
- CONTROL OF CELL DIVISION IN XENOPUS OOCYTESJAMES MALLER; Fiscal Year: 2003..Further work will examine the regulation, localization, and targets of PIx1 and identify kinases that activate xPIkk1. ..
- S6 Phosphorylation & Tyrosine Protein KinasesJAMES MALLER; Fiscal Year: 2004..p90Rsk phosphorylates and activates the spindle assembly checkpoint component Bub1. Bub1 activity has been linked to inhibition of the anaphase-promoting complex, which targets key proteins for ..
- Gene-Environment Interplay in Adolescent Alcohol UseDanielle M Dick; Fiscal Year: 2010..abstract_text> ..
- SPINDLE ASSEMBLY CHECKPOINT IN VERTEBRATES AND YEASTRey Huei Chen; Fiscal Year: 2003..The knowledge will then be applied to the question of how the deregulation of the checkpoint function may contribute to cancer progression. ..
- Regulation of the Anaphase-Promoting Complex by the Spindle CheckpointHongtao Yu; Fiscal Year: 2010..assisted conformational change of Mad2 in MCC assembly;(2) to determine the role of phosphorylation of Cdc20 by Bub1 in MCC assembly;and (3) to determine the role of Cdc20 autoubiquitination and degradation in MCC disassembly...
- Function of the chromosomal kinase haspin in mitosisJONATHAN M HIGGINS; Fiscal Year: 2010..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
- TRANSCRIPTOME OF METASTATIC PROSTATE CANCERGennadi Glinsky; Fiscal Year: 2005..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..
- TGFb Regulation of ER Receptor Positive Mammary CellsMARY BARCELLOS HOFF; Fiscal Year: 2006..3: To determine whether TGF-beta regulation of the ER+ subpopulation contributes to progression and/or features of preneoplastic lesions. ..
- Motif-based elucidation of protein modification codesJONATHAN HIGGINS; Fiscal Year: 2006..The development of methodology to determine the functional impact of these marks is therefore a critical requirement for future work in all areas of biomedicine. [unreadable] [unreadable]..
- PLK3 in the DNA damage checkpoint and tumor suppressionWei Dai; Fiscal Year: 2007..abstract_text> ..
- Mammal Cecropins as Antibiotics for Corneal InfectionsWei Dai; Fiscal Year: 2004..Phase II will be aimed at testing the efficacy and potential side-effects of mammalian cecropins using animal model systems as well as at regulatory submission and clinical testing. ..
- Protection of Centromeric Cohesion by Bub1 and Sgo1Hongtao Yu; Fiscal Year: 2010..of Plk1 /Aurora B in prophase? We have recently provided evidence to suggest that the spindle checkpoint kinase Bub1 targets and the Sgo1 centromeric protein and protein phosphatase 2A (PP2A) to centromeres where they counteract the ..
- Protein Interactions of the Germ Cell Kinase HaspinJONATHAN HIGGINS; Fiscal Year: 2004..abstract_text> ..
- A novel mouse colon cancer model and chemopreventionWei Dai; Fiscal Year: 2010..The long-term goal of this project is to elucidate the mechanism by which cell cycle checkpoints and the Wnt signaling pathway regulate cell proliferation and differentiation as well as genomic stability. ..
- Development of a haspin kinase assay for high throughput drug screeningJONATHAN HIGGINS; Fiscal Year: 2008..Furthermore, such inhibitors will provide an excellent way to validate haspin as a target for cancer treatment, and they might find direct application as chemotherapeutic drugs. [unreadable] [unreadable] [unreadable]..


text:
Related quotes
"I continue to get further away from the usual painter's tools such as easel, palette, brushes, etc. I prefer sticks, trowels, knives and dripping fluid paint or a heavy impasto with sand, broken glass or other foreign matter added."
"That's how close things are sometimes. That goes in and all of a sudden it's a fresh sheet of ice for (overtime)."
"The only thing we can think of is they were dumped here by the glaciers when the continental ice sheet melted away in this area 11,000 years ago."
"The story is still unfolding, but the dramatic changes at the margins are quite striking. I expect increased ice-sheet discharge to continue, with the result being further acceleration in sea-level rise."
"The ocean is the vehicle by which this heat is getting to the edges of the ice sheets, so if you increase the rate at which you're putting heat into the ocean, then it would further accelerate the melting."


text:
I will design a sleek Business PowerPoint and infographics(3)
About This Gig
Do you want to impress your audience, but don't have the time to create or design a killer PowerPoint presentation yourself?
Stop here! and check out what I am offering.
My POWER POINT Services are:
- Creating a New PowerPoint from a provided outline.
- Optimizing an Existing PowerPoint.
- Creation or Insertion of Charts & Graphs.
- Insertion of provided Photos.
- Convert PowerPoint into Video or into PDF.
Moreover, as a business entrepreneurship student, I am a specialist in office management tools and have designed more than 50 business presentations for successful start-ups.
so i am good and experienced person to design and create power point presentations for you.
I can make your presentations in 1 hour with the best quality you can imagine.
You will be satisfied with my work.


text:
Telstra Business Awards 2014 – National Winner!
Urban Escape wins the Micro-Business Award at the Telstra Business Awards 2014 On Thursday 7 August at a full and buzzing Gala Dinner at the Palladium at Crown, Urban Escape Hair was crowned the National Winner of the 2014 Micro-Business Award at the 2014 National Telstra Business Awards. After the win at state level, this was truly a surprise and an opportunity …Read More
Australian Achiever Awards 2014
The team at Urban Escape Hair were thrilled to receive some incredible news last week. Urban Escape has been awarded National Winner of the 2014 Australian Achiever Awards for Australia's Hairdressing Services! We are just over the moon about this award, and that we scored 98.62% for customer relations and services by the assessing panel. We love our craft, our Guests and most …Read More


text:
Literally, worst. Experience. EVER. I was forced to give a star rating, but if I could leave it at ZERO STARS, I would. DO NOT WASTE YOUR TIME!
I went home and cried, she left my hair looking absolutely hideous. Completely unprofessional, the job was so rushed. I could have done a better job myself and I know fuck all about hair. I laugh at the fact that there is a COLLAGE of "Advanced Hairstylist" certificates on the wall and she lets her clients leave looking a hot mess. I wasted my money, my time, and have absolutely nothing to show for it. Please, for the love of all that is Holy, DO NOT GO HERE. There are other salons that will do a much better job, treat you like a well-deserving client, and ensure that you leave satisfied. No one should rush while doing your hair, it reflects poorly on them and leaves you looking absolutely ratchet; clearly, the stylists at Platinum don't care about that one.


text:
Brady's is Not Undefeated at Home since late '06
Discussion in 'The Practice Squad' started by groundgame, Dec 14, 2010.
- Thread Status:
- Not open for further replies.
- Thread Status:
- Not open for further replies.
Apparently @DDuggan21 runs the Colts now. https://t.co/j63T9UJ25U
RT @JasonLaCanfora: Chiefs have officially indicated to DL Dontari Poe he will not be tagged. He's hitting the open market
Very easy to reach the 89% cash spending requirement. https://t.co/XeyyMnIAsN
This has been done in the past. https://t.co/YmxfuVynmV
No pressure at all haha I'm here!!! #NFLCombine https://t.co/XytZIWNoFb
The last sentence specifically lists the two components of a team's adjusted cap number. Does not mention adjustmen… https://t.co/0LBBcN4uZg
@chante_frelot Also could be a situation where he's seeking a different defensive system (maybe a pure 4-3).
@BillyFletch I wouldn't say impressed. But I understand his efforts to create multiple alternative theories to introduce reasonable doubt.
The original Snoop Dog nails it yet again. #Snoopy https://t.co/5TNrd5XL3y
Chris Long says he won't be back with the Patriots. Played 60.1% of snaps in 2016, with 4 sacks in 19 games https://t.co/UwU1wCwj2u
RT @DougKyed: Chris Long explains why he's not going to re-sign with the Patriots. https://t.co/b6KlvCZA74 https://t.co/H842UoqGp9
@PanEros33 @HailtotheHoodie you didn't get that I got the joke. Delete YOUR account
Chris Long announces on Instagram that he won't return to the patriots next season https://t.co/Veb2mthCO6
@JOEL9ONE Best of luck! Had fun watching you and happy your mission here was accomplished!
No, since I have been expecting Ryan to leave in free agency. https://t.co/7p55drGL5f
Benoit Hogue is available. He's only 50.
Chris Long's goodbye to the #Patriots https://t.co/0oByRDUKuB …#Patriots
Chris Long says on Instagram he won't be returning to New England next season https://t.co/7NrF9yEgB2
I owe y'all a lot!! Thank you! https://t.co/nJq0rrRLKf
DE Chris Long posted that he won't be back with the Patriots in free agency. https://t.co/IgUjwNi1Je
RT @JonFDOY: 12 minutes to go and the Bruins haven't done anything dumb. I can only assume they locked Neely in a closet.
RT @zeus30hightower: I have not one negative thing I say about this guy! Love and respect the hell out of you bro and wish the best you dam…
RT @Ian_OConnor: Darrelle Revis is an all-time Jets great & yet his biggest accomplishment was helping the Patriots win a ring. Only the Je…
The new 89% cash spending period starts on 4:01PM March 9th. It will cover four league years (2017/18/19/20). https://t.co/MJgkrWeLJf
Discussion in 'The Practice Squad' started by groundgame, Dec 14, 2010.


text:
Cream of Chicken Soup
|Chicken stock
|1 1⁄4 Liter
|Chicken breast
|60 Gram
|Plain flour
|4 Tablespoon
|Milk/1/2 milk and 1/2 cream
|625 Milliliter, scalded
|Celery stalks
|1 Small, finely chopped
|Tabasco sauce
|3 Drop
|Egg yolks
|To Taste
|To Taste
Prepare chicken stock and cut chicken breast into 5 mm (1/4-inch) pieces.
Melt butter in a large heavy saucepan, stir in flour, cook for about 1 minute, then add 625 ml (1 pint) chicken stock.
Stir continuously over a moderate heat until boiling.
Add remaining stock, scalded milk, chicken breast, celery, tabasco sauce, salt and pepper to taste and bring to the boil.
Reduce heat and simmer, covered, for 5 minutes.
Beat egg yolks well with a fork and put into a heated tureen.
Pour soup very slowly,over egg yolks, stirring all the time with a wooden spoon.
Serve immediately.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1763 Calories from Fat 844
% Daily Value*
Total Fat 95 g146.1%
Saturated Fat 50.2 g250.8%
Trans Fat 0 g
Cholesterol 698.9 mg233%
Sodium 2580.9 mg107.5%
Total Carbohydrates 127 g42.3%
Dietary Fiber 1.7 g7%
Sugars 53.2 g
Protein 100 g200.7%
Vitamin A 54.4% Vitamin C 8.5%
Calcium 82.9% Iron 28.5%
*Based on a 2000 Calorie diet


text: The Not-So-Real Dangers Of Power-LevelingMike Fahey4/21/10 9:00pmFiled to: ClipsaionNcsoftRooster TeethPower-levelingMmorpgPCDangerHumor132EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Aion developer NCsoft and Rooster Teeth have teamed up to educate massively-multiplayer online game players about the dangers of mafia-run power-leveling operations that probably don't exist. Advertisement Yes, power-leveling services are a bad idea. You have to hand your username and password over to strangers, who then have access to all of your personal information, or at least your name and address, which they can then use to mail you very nasty letters.There are dangers involved with employing such services that go beyond breaking a game's end-user agreement, but they can generally be avoided. Changing your password before handing it over to the service, putting in false personal information and then changing it back once the account is back in your hands, and similar precautions can keep the mafia off your back. Advertisement But really, why the hell would you power-level anyway? It's all about enjoying the game, isn't it?Oh, and also, this is not laugh-out-loud funny, no matter what the Aion post says.The More You MMO #2 - A Bad Deal [Aion]Reply132 repliesLeave a reply


text:
The Women's Tahoe Short Sleeve 10 Button Chef Coat by Uncommon Threads is designed specifically for a woman's body. It is designed to be lightweight and comfortable. Even when bending and stooping, chefs will not feel restricted in their movements. The length of the jacket comes to the upper thigh area.
For durability, reverse bar tacking and finished cuffs/collars are implemented into the design.
Both pockets are on the left side of the chef coat. The thermometer pocket is on the left upper arm area. The thermometer pocket also suffices as a resting place for pens or markers for use during service and prep periods.
Select the right color for your employer's uniform guidelines. The button color will match the color of the jacket selected. There is ample room on the chef coat for an embroidered name/employer name patch.