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I'm able to play the beta fine but there is no sound once I boot into Destiny. PS menu sounds work just not in the beta itself. Please help!
Have you checked your TV settings just to be sure? All cables are connected correctly? I'd try rebooting the system and game.


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Villa in Penela, Silver Coast, Portugal - Peaceful Locations With Wide Choice Of Nearby Places To Visit, And Things To Do
Hortas is a charming 5 bedroom villa that sleeps 10 and is the perfect spot for enjoying a peaceful and relaxing holiday in the centre of Portugal with its rich history and varied landscapes. Surrounding the house is a big and beautiful private garden which enjoys stunning views of the rural valley and the mountains in the distance. The sun shines on the swimming pool all day long and from the sun loungers you look up to the medieval castle of Penela perched on the hill. The pool has an electric safety cover and it can be heated too (optional extra and not usually required June-Sept). The house opens out to a covered terrace that is shaded all day long and ideal for alfresco dining. Also there is a kids´ room with toys and games, and the garden has a wooden playground with swings and slide making this villa ideal for family holidays with children.
About the Owner
0 Reviews
Activity and Interests
The long, sandy stretch of coastline north of Figueira de Foz is only 1 hours drive away, with beautiful beaches such as Praia Quiaios and Praia Tocha. Alternatively, closer by are lakes such as Pedrogao Grande (30 minutes drive), and river swimming pools such as the stunning gorge of Fragas de Sao Simao (20 minutes drive), both great for days out and both with lovely local restaurants.
Lisbon airport is 180kms away, and Porto airport is 160kms away. Both airports are an easy motorway drive away from villa taking within 1 hour 45 mins.
Car hire is essential for getting around.
Further Details:
The historical town of Penela is only 3 minutes drive up the hill, and nearby there is a wide choice of places to visit and things to do;
Coimbra University and its 18th Century Baroque Library
Coimbra Roman Sé Velha Cathedral and cloisters
Coimbra Botanical Gardens with high-rope climbing adventure park
Canoeing in the River Mondego
Biological Nature Park of Miranda do Corvo
Waterslide Park of Pombal
Schist village of Casal de Sao Simao,
Swimming in the river gorge of Fragas de Sao Simao
Nature walk to waterfall of Pedra Ferida
Roman ruins of Conimbriga
Tomar and the Knight Templar Convento do Cristo
49kms rail trail cycle path along the Dao River
Beaches in Figueira de Foz, Quiaios and Tocha
Arouce Castle, and Sanctuary of Nossa Senhora da Piedade in Lousa
Prices and Availability
Rental rates
Additional pricing information
|No additional mandatory fees
|Refundable Damage Deposit
Booking Notes:
25% deposit on confirmation of the booking. The balance is payable 6 weeks prior to arrival. £200 breakages deposit taken at time of final payment which is reimbursed by BACS immediately after vacation of the villa.
Changeover Day:
Change over day: Saturday in high season, flexible rest of the year.
Check-in time 16.00, check-out time 10.00.
Notes on prices:
Payment can be made by BACS. 10% discount on quoted rentals for parties of 6 people or less (Except July and August). Optional pool heating charge £200 per week during the low season - not usually required June-Sept.
Owner's Cancellation Policy
- 12
- Available arrival
- 12
- Available
- 12
- Unavailable
Property Type
- villa
- Heating
- Internet
- Iron & Board
- Living Room ...
- Parking
- Washing Machine
- Dishwasher
- Freezer
- Kitchen ...
- Microwave
- Oven
- Refrigerator
- Hob
- Child's Highchair
- Satellite / Cable
- Television
Pool / Spa
- Heated Pool
- Private Pool
- children welcome
- suitable for elderly or infirm
Location Type
- mountain
- rural
- Bathroom 1 - Toilet, Bath (no shower), Shower Enclosure
- Bathroom 2 - Toilet, Bath (no shower), Shower Enclosure, Bidet
- Toilet 1 - Toilet
- En-suite bathroom to bedroom 1 with shower Bathroom with bath and shower WC (ground floor)
- 5 Bedrooms, Sleeps 10
- Bedroom 1 - 1 Cot
- Bedroom 2
- Bedroom 3
- Bedroom 4
- Bedroom 5
- Description of sleeping capacity: Sleeps 10 (5 Bedrooms) Notes on bedrooms: Bedroom 1 with double bed and en-suite bathroom Bedroom 2 with double bed Bedroom 3 with twin beds Bedroom 4 with 3 childrens´ beds Bedroom 5 with double bed (ground floor)
- Golf ...
- Garden
- Barbecue
- Outside: A large private pool (11m x 5m) with is positioned just in front of the villa and gets the sun all day long. Pool has electric cover and is complete with sun loungers and parasols. Pool heating is also available (at additional cost). Large and lovely garden, with olive trees and stunning views. Wooden playground for kids. Portable BBQ. Shaded terrace with robust dining table offering plenty of space for all the guests; the perfect spot to wine and dine on long summer days. Cleaning / Towels / Linen / Maid service: Maid service 3 times a week Bed linen is included and is changed once per week. Bath towels changed mid-week. Pool towels changed once per week. Other: Kids playroom with books, toys and games for children to enjoy.

subset: commoncrawl


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Atiku, Farooq and Lea-Langton, Amanda and Bartle, Keith and Jones, Jenny and Williams, Alan and Burns, Iain and Humphries, Gordon Samuel (2017) Some aspects of the mechanism of formation of smoke from the combustion of wood. Energy and Fuels. ISSN 0887-0624 (In Press)
Javid, Nadeem and Kendall, Thomas and Burns, Iain and Sefcik, Jan (2016) Filtration suppresses laser-induced nucleation of glycine in aqueous solutions. Crystal Growth and Design, 16. ISSN 1528-7483
Borggren, Jesper and Burns, Iain S. and Sahlberg, Anna-Lena and Aldén, Marcus and Li, Zhongshan (2016) Temperature imaging in low pressure flames using diode laser two-line atomic fluorescence employing a novel indium seeding technique. Applied Physics B: Lasers and Optics, 122 (3). ISSN 0946-2171
Sellars, Philip B. and Lue, Leo and Burns, Iain S. and Work, D. Neil (2016) Freezing properties of alkenyl succinic anhydrides derived from linear isomerised olefins. Industrial and Engineering Chemistry Research. ISSN 0888-5885
Humphries, Gordon S. and Burns, Iain S. and Lengden, Michael (2016) Application of continuous-wave cavity ring-down spectroscopy to laminar flames. IEEE Photonics Journal, 8 (1). ISSN 1943-0655
Forsyth, Carol and Burns, Iain S. and Mulheran, Paul A. and Sefcik, Jan (2016) Scaling of glycine nucleation kinetics with shear rate and glass-liquid interfacial area. Crystal Growth and Design, 16 (1). 136–144. ISSN 1528-7483
Humphries, G. S. and Dunn, J. and Hossain, M. M. and Lengden, M. and Burns, I. S. and Black, J. D. (2015) A simple photoacoustic method for the in-situ study of soot distribution in flames. Applied Physics B: Lasers and Optics, 119 (4). pp. 709-715. ISSN 0946-2171
El Bakali, A and Mercier, Xavier and Wartel, Maxime and Acevedo, F and Burns, Iain and Gasnot, L and Pauwels, J-F and Desgroux, P. (2012) Modeling of PAHs in low pressure sooting premixed methane flame. Energy, 43 (1). 73–84. ISSN 1873-6785
Sypek, Katarzyna Joanna and Burns, Iain and Florence, Alastair and Sefcik, Jan (2012) In situ monitoring of stirring effects on polymorphic transformations during cooling crystallization of carbamazepine. Crystal Growth and Design, 12 (10). pp. 4821-4828. ISSN 1528-7483
Chrystie, Robin S.M. and Burns, Iain and Kaminski, C.F. (2012) Temperature response of an acoustically-forced turbulent lean premixed flame : a quantitative experimental determination. Combustion Science and Technology. ISSN 0010-2202
Burns, Iain and Kaminski, C.F. (2011) Diode laser induced fluorescence for gas-phase diagnostics. Zeitschrift für Physikalische Chemie, 225 (11-12). pp. 1343-1368. ISSN 0942-9352
Laurila, T. and Burns, I. S. and Hult, J. and Miller, J. H. and Kaminski, C. F. (2011) A calibration method for broad-bandwidth cavity enhanced absorption spectroscopy performed with supercontinuum radiation. Applied Physics B: Lasers and Optics, 102 (2). pp. 271-278. ISSN 0946-2171
Burns, Iain S. and Mercier, Xavier and Wartel, Maxime and Chrystie, Robin S.M. and Hult, J. and Kaminski, C.F. (2011) A method for performing high accuracy temperature measurements in low-pressure sooting flames using two-line atomic fluorescence. Proceedings of the Combustion Institute, 33 (1). pp. 799-806. ISSN 1540-7489
Chrystie, Robin S.M. and Burns, Iain S. and Hult, J. and Kaminski, C.F. (2009) High-repetition-rate combustion thermometry with two-line atomic fluorescence excited by diode lasers. Optics Letters, 34 (16). pp. 2492-2494. ISSN 0146-9592
Burns, I.S. and Lamoureux, N. and Kaminski, C.F. and Hult, J. and Desgroux, P. (2008) Diode laser atomic fluorescence temperature measurements in low-pressure flames. Applied Physics B: Lasers and Optics, 93 (4). pp. 907-914. ISSN 0946-2171
Chrystie, Robin S.M. and Burns, I.S. and Hult, J. and Kaminski, C.F. (2008) On the improvement of two-dimensional curvature computation and its application to turbulent premixed flame correlations. Measurement Science and Technology, 19 (12). ISSN 0957-0233
Burns, I.S. and Hult, J. and Hartung, G. and Kaminski, C.F. (2007) A thermometry technique based on atomic lineshapes using diode laser LIF in flames. Proceedings of the Combustion Institute, 31 (1). pp. 775-782. ISSN 1540-7489
Burns, I.S. and Hult, J. and Kaminski, C.F. (2006) Use of Te-130(2) for frequency referencing and active stabilisation of a violet extended cavity diode laser. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 63 (5). pp. 905-909. ISSN 1386-1425
Hult, J. and Burns, I.S. and Kaminski, C.F. (2005) High repetition-rate wavelength tuning of an extended cavity diodelaser for gas phase sensing. Applied Physics B: Lasers and Optics, 81 (6). pp. 757-760. ISSN 0946-2171
Hult, J. and Burns, I.S. and Kaminski, C.F. (2005) Wide-bandwidth mode-hop-free tuning of extended-cavity GaN diode lasers. Applied Optics, 44 (18). pp. 3675-3685. ISSN 1559-128X
Hult, J. and Burns, I.S. and Kaminski, C.F. (2005) Two-line atomic fluorescence flame thermometry using diode lasers. Proceedings of the Combustion Institute, 30 (1). pp. 1535-1543. ISSN 1540-7489
Burns, I.S. and Hult, J. and Kaminski, C.F. (2004) Spectroscopic use of a novel blue diode laser in a wavelength region around 450 nm. Applied Physics B: Lasers and Optics, 79 (4). pp. 491-495. ISSN 0946-2171
Hult, J. and Burns, I.S. and Kaminski, C.F. (2004) Measurements of the indium hyperfine structure in an atmospheric-pressure flame by use of diode-laser-induced fluorescence. Optics Letters, 29 (8). pp. 827-829.
Book Section
Humphries, Gordon and Lengden, Michael and Burns, Iain and Black, John (2015) Novel in-situ optical measurement techniques for combustion applications. In: Advanced Photonics 2015, OSA Technical Digest. Optical Society of America. ISBN 978-1-55752-000-5
Conference or Workshop Item
Humphries, Gordon Samuel and Burns, Iain and Lengden, Michael (2014) Development of a continuous-wave cavity ring down spectrometer for combustion diagnostics. In: FLAIR 2014 - Field Laser Applications in Industry and Research, 2014-05-05 - 2014-05-09.


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C. S. Lewis Then and Nowby Wesley A. Kort
Clive Staples Lewis (1898-1963) was a distinguished scholar of medieval and Renaissance literature who taught at both Oxford University and Cambridge University. After his conversion to Christianity, Lewis began writing Christian apologetic works aimed at a popular audience. It is for these works that Lewis is now best remembered; especially in the U.S., where his
Clive Staples Lewis (1898-1963) was a distinguished scholar of medieval and Renaissance literature who taught at both Oxford University and Cambridge University. After his conversion to Christianity, Lewis began writing Christian apologetic works aimed at a popular audience. It is for these works that Lewis is now best remembered; especially in the U.S., where his books have sold in the millions and continue to be popular today. Perhaps because of this popularity, however, Lewis's Christian writings are generally dismissed by theologians as oversimplified and conceptually flawed. With this book, Wesley A. Kort hopes to rehabilitate Lewis and to demonstrate the value and continuing relevance of his work.
Editorial Reviews
"[Kort] penetrated Lewis's world in a way that few before him had."America
"Wesley Kort has given us a literary Rosetta Stone to update and understand some of Lewis' themes that are pertinent to contemporary life."Presbyterian Outlook
"Wesley Kort takes the opportunity of C.S. Lewis's recent centenary to assess the author's ongoing appeal, to examine his critique of modern culture, and to explore the varied riches he has personally found in decades of rereading. Taking into account a wide-ranging legacy of fiction, autobiography, and essay, he concentrates his attention on Lewis's ability to imagine a rich, collective life a shared communal vision. Kort argues that the post-modern world in which we live is ripe for a writer so adept at building bridges between various constituencies, so versatile in his mastery of different kinds of writing. After years of teaching Lewis to Duke undergraduates, he now brings his smart, timely discoveries to the rest of us."Peter S. Hawkins, Boston University
"This book should contribute to a greater appreciation of C.S. Lewis by all levels of readers."Choice
"C. S. Lewis Then and Now promises to make Lewis compelling not only to many lay people, but also to the kind of academic religious studies reader who (unlike millions of lay readers, many of them Christians of various sorts) has not been able to appreciate him. Kort shows that Lewis was not only criticizing 'modern culture' but looking for a fruitful, interactive relationship between Christianity and culture."Larry D. Bouchard, University of Virginia
Product Details
- 9780195176636
- Publisher:
- Oxford University Press
- Publication date:
- 09/23/2004
- Pages:
- 208
- Product dimensions:
- 9.10(w) x 6.10(h) x 0.70(d)
Read an Excerpt
Chapter One
The recent centennial of C. S. Lewis's birth marked a time not of decline but of increase in the potential importance of his work for American readers, especially in academic settings. Some of the earlier academic neglect is traceable to the diversity of his oeuvre, its cultural engagements, rhetorical style, and contributions to popular culture, especially science fiction and children's literature. But the academic climate, especially in literary studies, has changed. The formalism and disciplinary orthodoxy characteristic of English departments a few years ago kept them from accommodating the full range of Lewis's work. But now literary studies are interdisciplinary and take into account matters of theory and practice that also engaged Lewis. These include education and curricula, the consequences of bureaucracies for social space, value theory, the continuities between high and popular culture, the relation of power and ideology to beliefs and ideas, and what are taken to be the moral consequences of intellectual and technological imperialism.
The combination of literary with historical, theoretical, cultural, critical, and moral/religious ingredients normalizes Lewis's work in current literary studies. Literary studies increasingly are marked by intersections where literary and cultural interests, questions of belief and value, and awareness of popular culture, rhetoric, and social/economic power meet and interact. C. S. Lewis sounds at times like Stanley Fish, a major mover in recent changes within academic literary studies. At onepoint Lewis writes, "I do not think that Rhetoric and Poetry are distinguished by manipulation of an audience in the one and, in the other, a pure self-expression, regarded as its own end, and indifferent to any audience. Both these acts, in my opinion, definitely aim at doing something to an audience and both do it by using language to control what already exists in our minds." One could stitch that statement into one of Fish's essays on rhetoric in literary-critical work without leaving a seam.
Half a century ago literary environments were inhospitable to such collapsing of distinctions and such diversity of interest and genre. Academic attention to Lewis was primarily established and sustained by people drawn to the specifically religious aspects of his work. Lewis encouraged conservative Protestant literary scholars to relate their intellectual interests to their own Christian identities and beliefs. During the decades immediately following the Second World War, faculty in evangelical colleges and religiously conservative literary scholars in other institutions turned to Lewis as someone who articulated traditional Christian beliefs and values to academic culture. Lewis provided a model for those who wanted to maintain the role of Christian faith in intellectual life or were unwilling to let an increasingly secular academic culture marginalize the religious aspects of English and American literature and declare religious beliefs irrelevant to literary-critical tasks.
At the same time, there were other models for increasing the role of moral and religious interests in academic work. While Lewis appealed primarily to conservative Protestant intellectuals, scholars like Jacques Maritain provided a similar model for their Catholic counterparts. Like Lewis, Maritain received his education in an increasingly non- or even anti-religious academic environment that he also finally found personally unsatisfying and philosophically vulnerable. Maritain searched for alternatives to secular and materialist assumptions, converted to Catholicism, and worked out of a general Thomist philosophical orientation. Coming to the United States at the beginning of the war to teach philosophy first at Columbia and then at Princeton University, Maritain was able, along with others, to promote Thomist philosophy in secular settings. He extended the interests of Christian faith not only into moral philosophy but also into wider areas such as political and aesthetic theory. Lewis, while not so fully Thomist as Maritain, also drew heavily on medieval texts of Christian literature and philosophy, criticized modern culture for its neglect of traditional values, and articulated religious interests in scholarship and an intellectually examined religious account of the world. Both, in their differing ways and for differing audiences, were crucial figures for the changing climate of postwar American academic culture, which increasingly allowed for the articulation of moral and religious beliefs within literary, philosophical, and cultural studies.
During the latter half of the twentieth century, academic culture underwent a gradual reversal of the tendency during the first half to marginalize or exclude religion and religious interests in or from intellectual work. The increasingly confident secularism of the prewar decades was replaced by greater uncertainty and by an appreciation for the religious life of different cultures, particularly Asian. The traumas of war, rapid social change, and the internationalization of American culture have all contributed to an increased incorporation of religion into academic life. This new academic interest in religion joins the increasingly complex character of literary and cultural studies to presage a relevance of Lewis's work to academic, particularly literary, culture today.
Academic interest in Lewis has all along been paralleled by the continuing interest in Lewis among intelligent Christian readers in America outside the academy. It is perhaps more difficult to account for this broader admiration. Lewis, a smoking, alcohol-drinking British academic without strong doctrines of biblical authority or the Holy Spirit, seems exotic in relation to American evangelical culture and theology. His appeal very likely lay in the combination of his readable style with certain characteristics of his theological views. We should note that Lewis, like evangelicals, did not position himself primarily within or in defense of the church but spoke from and to a more personally oriented and construed faith. He was also sharply at odds with the main currents of modernity, as were readers of a conservative Protestant orientation. It was very likely helpful, too, that Lewis could be read as politically and socially conservative. This was possible not only because of his focus on personal faith rather than on a social gospel or political theology but also because he desired not to subvert public institutions but instead to realign them with their traditional sources. Finally, Lewis gave encouragement to intelligent lay readers in the face of disconcerting and popular theological currents of the postwar period such as the aggressively marketed "death of God" movement.
Academics and laity who admired Lewis and used his work as a resource and model for the redeployment of Christian belief in the context of modern culture came together to create centers of Lewis study such as that located at Wheaton College in Illinois. An evangelical institution of high academic standards, Wheaton melded the scholarly interest of some of its faculty in the work of Lewis with the popularity of his books among its intelligent constituency, and that combination has characterized similar institutions throughout the country.
Americans' interest in Lewis was not confined to such circles, however. The Narnia Chronicles found their way into public and school libraries throughout the country. Some of his work also had a recognized academic standing, although not on a level equal to other major English influences on American literary and philosophical studies during the period. Several of his books were standard in bibliographies of medieval and Renaissance literature and on Milton, and some of his writings on theodicy, miracles, and religious experience found their ways into anthologies and college textbooks on philosophy of religion. This broader interest, both popular and academic, was exploited, if that is not too harsh a word, by the Hollywood filming of Shadowlands. More sentimental than the BBC filming of the stage play, it constructed a relation between Lewis and themes dear to Americans, such as the inadequacy of intellectual, particularly theological, formulations in relation to experience, especially suffering, and the healing resources of the natural context of human life. However, it is fair to say that although the work of Lewis has had a wider currency in the culture, its appeal remains concentrated in the homes, offices, and institutions of conservative Protestant Americans, academic and lay.
It would be unfortunate if that limited concentration continued. In my opinion Lewis is increasingly relevant to the culture of American literary studies. At century's end, literary studies resemble hardly at all what was dominant a half century ago, and the change is such that it produces a far more fertile ground for the dissemination of his work. It is possible now to retrieve Lewis's work from the quarters in which during the past decades it has been largely confined, while also fortunately guarded and admired.
The attempt to position Lewis's work more fully within the interests of current literary academia involves a two-part effort. It must first demonstrate that Lewis should not be confined to parochial religious and cultural interests. It must then challenge an academic, literary culture that, due to the loss of certainty, is governed increasingly by the dynamics of distrust and the vagaries of personal, professional, and institutional power.
Mention of some negative strains in current literary culture should not send us in search of more receptive academic terrain in departments of religion or theological faculties. Those settings are presently structured by two contrary movements both inhospitable to Lewis. The first is sponsored by the ongoing attempt to subordinate religion to other ends, either to account for it in social scientific or historical terms or to harness it to political or psychological interests. The second movement is one that, rather than account for religion in other terms or subordinate it to something else, allows religion to be an account of the world and of people's relation to and in it but only in the context of specific religious traditions, communities, and institutions. Lewis can be aligned with neither of these two contrary and mutually aggravating campaigns. He does not subject religion, either in its origin or in its consequences, to other interests or terms, and he wants the account of things that religion can provide to be tested in and related to public culture.
Lewis, as I understand him, thus finds more potential appreciation and use in departments of literature than in departments of religious studies or theological schools. His diverse interests in cultural theory and criticism, rhetoric and power, in institutions, moral theory, popular culture, and even children's literature suit today's literature departments. While it would not do to call Lewis a postmodernist, it is nonetheless true that the interests that drive and shape his work (and that alienated him from mid-century academic culture) conform with those that mark current literary studies. However, Lewis also represents a potential challenge to current literary culture. That challenge asks whether the breakdown of traditional barriers, authorities, and distinctions in literary studies commits departments of literature to anti-religious and amoral ideologies. While Lewis shares much with the present ethos of literary and cultural studies, he does not share their present obsession with and deference to power, especially to power governed by nothing more than a market economy, the boundaries and directives of the profession or institution, and the self-interests of those who count themselves among the academic stars. There are, however, close parallels between the interests and style of Lewis and those of current literature faculties. They share a penchant for autobiography and personal reference, an intense but critical interest in culture, including popular culture, a skepticism toward the prevailing centers of academic and social power, and a strongly polemical style. But Lewis reveals that these interests and styles are not necessarily wedded to skeptical or self-serving motives and results but can also serve positive, public moral and spiritual ends.
It is helpful to notice that Lewis did not advocate religion and morality as something extraneous to literary scholarship and imparted to it from some other source. Religious and moral interests were integral to the material he studied and the critical work in which he engaged. As he points out in his autobiography, he was led to Christianity because it allowed him to take more fully into account what was important to many philosophical and literary texts and also to those intellectual and aesthetic experiences that he found to be significant and engaging. No source or authority, institutional or textual, needed to be invoked other than those already operative in and for his work: literary texts, their cultural contexts and consequences, and the tools of literary and cultural theory and criticism. A moral and religious disposition, he believed, provides a more adequate or appropriate setting or context for critical, interpretive, and constructive literary and cultural work than its modern, skeptical alternatives. Lewis could speak from religious belief and moral concern without alienating himself from or disenfranchising himself within English literary, humanistic academic culture.
The challenge to current literary studies that lies in Lewis's practice should not be missed. He did not have to pursue the moral and spiritual aspects of literary texts by bringing something to them from the outside. But literary studies unable or unwilling to take such matters into account and, a fortiori, those that actively discount them or reduce them to something less or other, must do so by deferring to something extrinsic to the reading of texts.
Finally, it is important to note that Lewis stressed those elements of religious faith and practice commodious and flexible enough to take the moral and religious aspects of literary and cultural studies into account and to provide critiques of them. He was unfettered by ecclesiastical authority, theological dogmatism, or religious controversy. He employed moral inquiry and religious categories within a cultural tradition largely supplied by the texts that, as a philosopher turned literary historian and critic, he studied and taught. These materials needed only to be retrieved, selected, and redeployed. Understanding and appreciating literary and philosophical texts require taking them seriously as accounts of the world and of people's relations to and within it. It is necessary to imagine oneself into the worlds they make available. In analyzing a particular textual account, it is not extraneous or gratuitous to ask what is and is not illuminating or satisfying, particularly when compared to other accounts. This inevitably raises and addresses questions of moral and religious belief.
American literary academic culture has recently seen a thawing of the secular certainties that for decades sustained a repression or occlusion of the moral and religious language of literary texts or of their relation to the moral and spiritual needs and potentials of the culture. We find ourselves today in a situation in which Lewis's project should receive fuller hearing. Indeed, his project contains potential value for efforts now either beginning or called for to explore the relation of religion and ethics to cultural studies and critiques that have changed the nature of literary scholarship in America. The centennial observance of Lewis's birth coincided with the emergence of a literary culture suited to his broadly catholic and intellectually complex religious orientations and convictions. My attempt to retrieve Lewis is largely a response to these new cultural conditions.
It is helpful to recall the historical context in which Lewis prepared for and entered his vocation. It was a context in which cultural retrieval had convincing voices and a ready audience. Lewis engaged English studies at just the time when they became legitimate fields of academic inquiry at Oxford and Cambridge. An academic field newly institutionalized, English rapidly gained visibility and prestige. Perhaps the British literary critic and theorist Terry Eagleton exaggerates when he writes, "In the early 1920s it was desperately unclear why English was worth studying at all. In the early 1930s it had become a question of why it was worth wasting your time on anything else." He contends that in a very short time, one during which, we should keep in mind, Lewis entered the field as a student and as a teacher, English became the central subject, "immeasurably superior to law, science, politics, philosophy or history." But several factors give at least some credence to Eagleton's claims.
English, when Lewis entered it, had very much what we would now call a "cultural studies" shape. One reason for this is that literature was the chief source of England's cultural capital. In addition, the legitimacy and popularity of English studies were assured by the social concerns of young scholars who took it up. English provided the cultural content for an emerging academic population of middle-class sons among whom Lewis can be included. It provided a canon that both was subversive to the cultural authority of aristocrats and countered the emerging radical force of a political and social left.
In addition to such matters of cultural capital and authority and more to the point of our interests here, the rise of English studies also carried strong moral aims. English studies brought scholars in touch with the nineteenth-century affirmation of literature as a unifying and morally rectifying resource. Indeed, identification of literature and criticism with the moral and spiritual prospects of society was a constant in the nineteenth century, reaching its fullest statement in the work of Matthew Arnold. The retrieval or continuation of this agenda was undertaken both despite the consequences of the First World War and because of them. In the period immediately following the war, sharp discontinuities were felt between the post- and prewar societies. Radical changes in behavior and values, accompanied by greater mobility and rapidly increasing urbanization, created moral uncertainty and a diminished sense of shared values and norms. The rise of English as an academic discipline offered a counter-thrust to these radical changes by retrieving the moral content of the literary tradition and critical vocation, redeploying them in postwar culture. English studies created continuity with the literary tradition and warranted the role of the literary scholar as cultural critic and moral theorist.
Powerful philosophical currents also supported the emergence of English literary studies as a dominant intellectual force in Oxford. Idealism, with its stress on human reason, morality, and spirit, was very much a part of the academic climate of Oxford in the years of Lewis's development as a scholar. This encouraged him to bring classical and modern idealist perspectives to his literary work. They helped to shape his understanding of the imagination, to support his interest in the comprehensive range and unifying force of myth, to sustain his attention to essences and universals, to substantiate his confidence in human rationality, and to give relevance to medieval philosophy and literature and to such particular writers as Spenser, Milton, and the Romantics. Indeed, Lewis's philosophical and literary canon can be seen as strung on an idealist line from Plato to William Morris.
Retrieval, then, was a primary scholarly, cultural, and moral project for Lewis. But retrieval was never for him simply a matter of return. It could be argued that Lewis was infected with the kind of nostalgia that marked the Romantics he so much admired. I believe, however, that Lewis was as much a forward-looking person, both as scholar and as believer, as he was a retriever of the past. He looked for yet unheard-of advances in human development, and in this way he participated very much in the spirit of modernity. But he was also convinced that these advances would go awry if not steadied and directed by relations with the past. Respect and appreciation for the past does not mean control by or limitation to its achievements. It is a modern caricature of retrieval that sees it only as reactionary. The past is neither irrelevant to the present nor a repository of answers to the questions raised in and by present time.
Our own retrieval of Lewis also will be neither only a return to him nor an attempt to install his views as fully adequate to the needs of our present cultural location. We will walk a path between advocates of the present literary culture who see Lewis as hopelessly bound to and by his own culture and those opponents of current academic culture who are willing to see Lewis as adequate in the present time for recovering relations between religious/moral interests and literary/cultural studies. This work is aligned with his by its opposition to both these options. Lewis had a strong sense of historical change, and he understood that religion and morality are articulated and practiced in and for specific cultural situations. His own views and methods are both relevant to us now because some aspects of his culture persist today and not relevant to the extent that his situation as a mid-century Englishman differs from ours as Americans beginning a new century. Indeed, Lewis contends that appreciation of the past is necessary if a person is to recognize the present as also a distinct period and as having, therefore, its own limitations and "characteristic illusions." Given both the continuities and the contrasts between our cultural location and his, our retrieval of his work must be as selective, as relevant to the present situation, and as forward-looking as was his own. It is in the spirit of his retrievals, in other words, that this one is undertaken.
English academic culture is only one of the factors that help us to understand the development of Lewis's vocation. His own life experience, drifting away from his Christian upbringing and experimenting with a variety of belief options, also shaped his sense of vocation and academic identity. The post- or anti-Christian views he adopted as a young man were those he would later attack. Indeed, it is fair to say that he saw his own life as an epitome of a larger pattern that English culture could be seen as following. As he in his own life drifted away from Christian moorings into improvised and eclectic spiritualities and popular materialism and narcissism, so English culture neglected its ties to the past and its sense of shared morality and spiritual aspiration. He could address competing ideologies and orientations as one who knew them from within and had found them wanting. As he felt compelled to retrieve a relation to his religious past, so he also believed that the culture required a comparable change of orientation. It would be greatly impoverished if it did not and foreboded a severely limited and morally distorted future for English people. His analysis of the culture of the twenties and early thirties led him to see his own conversion and identity change as needed as well for those around him, especially in academic culture. It led him to attempts to compel them also to retrieve.
Lewis, like many others in the society, had given himself gradually to a popular, uncritical materialism. His conversion or return to Christianity by way of idealism led first to a recognition of the inadequacy of materialism's account of the mind and imagination. Idealism also allowed for an orientation to the Absolute, which Lewis understood as personal and active. Lewis, with his strong interest in moral theory, then recognized the moral identity of God and finally God's intrusion into human life. As he put it, "my own progress had been from 'popular realism' to Philosophical Idealism; from Idealism to Pantheism; from Pantheism to Theism; and from Theism to Christianity."
This sequence of events suggests the distance between his cultural location and our own. We live in a culture in which philosophical idealism does not provide, as it did for Lewis, a culturally available bridge to religious belief. Nor can attention to the moral and spiritual language of literary texts be defended, as it once was, by idealist philosophical beliefs. The decline and eventual disappearance of shared cultural idealism constitutes a major challenge today for any attempt to take the moral and religious significance of literary culture into account.
Excerpted from C. S. LEWIS THEN AND NOW by Wesley A. Kort. Copyright © 2001 by Wesley A. Kort. Excerpted by permission. All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Meet the Author
Wesley A. Kort is Professor of Religion at Duke University. His publications include "Take Read": Scripture, Textuality, and Cultural Practice (1996), Bound to Differ: The Dynamics of Theological Discourses (1992), and Story, Text, and Scripture: Literary Interests in Biblical Narrative (1988).
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A Romanian princess has pleaded guilty to charges connected with an illegal cockfighting operation at her ranch in rural Oregon.
Irina Walker, 61, is a great-great-great-granddaughter of Queen Victoria and the third daughter of the former Romanian King Michael I, who was forced to abdicate by the country's communist government in 1947.
Prosecutors said Ms Walker and her 68-year-old husband, John, held at least 10 cockfighting derbies in a barn at their ranch in Irrigon, Oregon, in 2012 and 2013. They were arrested last summer. On Wednesday, Mrs Walker pleaded guilty to a single count of operating an illegal gambling venture, telling US District Judge Michael Mosman that she had "provided food and beverages" for spectators at the events, for which knives, or "gaffs", are fitted to the legs of two cocks, which then fight to the death. The practice is illegal under federal and state law.
The authorities said the couple charged punters $20 (£11.70) to attend the events and $1,000 to enter their cock in a bout. The crowds reportedly numbered 100 or more and the betting pool reached as much as $18,000. According to USA Today, 10 per cent went to the referees, while the rest was won by the person whose cock emerged triumphant from the most fights.
Charges against another woman, hired to prepare tacos and burritos at the events, were dropped.
Born and raised in Switzerland, Irina moved to the US in 1983 with her first husband, whom she later divorced before marrying Mr Walker, a former sheriff's deputy. Mr Walker established the cockfighting operation with a veteran referee, Mario Perez, whose was among more than a dozen people indicted in the case.
Mr and Mrs Walker are due to be sentenced in October. The Government has recommended three-year probationary sentences for the couple, as well as the forfeiture of $200,000.Reuse content


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Get an overview of this hotelSuburban Rome hotel in EUR with free breakfast
Located in EUR, this hotel is within 9 mi (15 km) of Villa Romana, Museum of Roman Civilization, and Baths of Caracalla. Circus Maximus and Arch of Constantine are also within 9 mi (15 km).
Hotel Features
A restaurant, a rooftop terrace, and a seasonal outdoor pool are available at this hotel. Free buffet breakfast and free WiFi in public areas are also provided. Additionally, a business center, a meeting room, and concierge services are onsite.
Room Amenities
All 102 soundproofed rooms feature free WiFi and pillowtop beds. For a bit of entertainment, guests will find LCD TVs with digital channels and first-run movies, and other amenities include minibars and room service.Information missing or incorrect? Tell us!Opens in a new window
Ardeatina Park Hotel
Hotel Amenities
Hotel Amenities
The hotel offers a restaurant. Guests can enjoy a complimentary breakfast each morning. Public areas are equipped with complimentary high-speed wireless Internet access. This 4-star property offers access to a business center and a meeting room. This business-friendly hotel also offers a seasonal outdoor pool, a rooftop terrace, and multilingual staff. Concierge services and wedding services can be provided.
- Babysitting or childcare (surcharge)
- Restaurant
- Total number of rooms - 102
- Number of floors - 3
- Babysitting or childcare
- Business center
- Free breakfast
- Concierge services
- Dry cleaning/laundry service
- Elevator/lift
- Free WiFi
- Rooftop terrace
- Luggage storage
- One meeting room
- 24-hour front desk
- Garden
- Laundry facilities
- Multilingual staff
- Number of buildings/towers - 1
- Outdoor seasonal pool
- Television in common areas
- Wedding services
- Free newspapers in lobby
- Express check-in
- Express check-out
- Porter/bellhop
Family Friendly Amenities
- Family Hotel
- Free Wi-Fi
- Soundproofed rooms
- Laundry facilities
- Babysitting or childcare (surcharge)
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Room Amenities
- Free cribs/infant beds
- Room service (limited hours)
- Premium TV channels
- Air conditioning
- In-room climate control (air conditioning)
- Access via exterior corridors
- Minibar
- Daily housekeeping
- Private bathroom
- Free toiletries
- Hair dryer
- Bidet
- Shower/tub combination
- Desk
- First-run movies
- Digital TV service
- Free WiFi
- In-room safe (laptop compatible)
- Blackout drapes/curtains
- Soundproofed rooms
- Hypo-allergenic bedding available
- Pillowtop mattress
Where to Eat
Guests are offered a complimentary buffet breakfast each morning.
Ristorante Il Delfino - Overlooking the pool, this restaurant specializes in Italian cuisine and serves dinner only.
Room service (during limited hours) is available.
Nearby Things to Do
Recreational amenities at the hotel include a seasonal outdoor pool.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Ski equipment rental shops nearby
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- Roll-in shower
Hotel Policies
Check-in time starts at 1 PM
Check-in time ends at midnight
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Free cribs (infant beds)!
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
Parking height restrictions apply
The airport shuttle only goes to Ciampino–G. B. Pastine International Airport; it does not go to Leonardo da Vinci–Fiumicino Airport.
- A tax is imposed by the city: EUR 6 per person, per night, up to 10 nights. This tax does not apply to children under 10 years of age.
Hotel Name
- Ardeatina Park
- Ardeatina Park Hotel
- Ardeatina Park Hotel Rome
- Ardeatina Park Rome
We should mention
All guests, including children, must be present at check-in and show their government-issued photo ID card or passport. Cash transactions at this property cannot exceed EUR 2999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation. This property offers transfers from the airport. Guests must contact the property with arrival details before travel, using the contact information on the booking confirmation.


text: I have a Kodak Z650 digital camera which lets you record video in the .mov (Quicktime Movie) format. Recently I noticed that I can't move, rename or delete .mov files. Only when I uninstall the Quicktime player am I able to move, rename or delete .mov files. But then I am not able to view these files. When I try to delete, rename or move a .mov file I get the following error message: "It is being used by another person or program. Close any programs that might be using this file and try again." I am not aware of any other program running. I have turned off anything I am aware of. 1. What must I do to be able to view, rename, delete or move .mov-files? To be honest, I am not satisfied with the .mov format. I wished my Kodak digital camera would record .avi because that can directly be processed with Windows Movie Maker. 2. Is anybody aware of a free movie editor that can handle .mov? Apple offers the Quicktime Pro software for about 20 or 30 dollars. Would that program enable me to create movies and slideshows from .mov, .wmv, .avi and .jpg files. Does Quicktime Pro offer the ease of Windows Movie Maker. I would like to know more about the video editing capabilities of Quicktime Pro before making a purchase. Thank you for any information.


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Social Selling
Ivor Kellock
Social selling is a mix of sales & marketing skills - a specific set of skills - easily learned - with a set of key characteristics - a mix of art & science if you like
Here's a complete set of information gathered from a few different places to begin you on your journey of learning & success....;-)...
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Is Closing A Sale How You Define A New Piece Of Business
Ivor Kellock
As more people become self employed to create their income & wealth & new terms like inbound marketing & attracting buyers become generally accepted terms - what do you call it when you close a new deal?
I've been in sales since 1984 so I guess I am somewhat old school or an old timer! I call i...
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Locatie en stad
|Check-in vanaf
|Check-out tot
- Eigen parkeerplaats
- Kluizen bij de receptie
- IJsmachine
- Buitenzwembad
Services in het hotel
- Business Center
- Wasservice
Stijl en sfeer van het hotel
Year built - 1969 year remodeled - 2015, world s largest, 4,100 hotels - 83 countries - 1 standard , that is our idea of commitment. It does not, matter which hotel you choose, you will always, benefit from bestrequests - our worldwide, standard for service and amenities. The majority, of best western properties offer a continental or, hot breakfast either complimentary or at a, nominal fee. You will also enjoy with your stay, are: , * data ports in all rooms , * free local calls under 30 minutes , * free long distance access , * complimentary in-room coffee/tea maker , * 50 % non-smoking rooms , * hair dryer, iron/ironing board in every room , * plus much more , bestrequests - now, one single standard of, service. , Free long distance access and local calls in the, u.S. And canada only. Amenities may vary, slightly at international hotels., Time zone - est
Totaal aantal kamers 87, Meetinghotel / congreshotel, Kindervriendelijk hotel
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1540 SAVANNAH HIGHWAY, 29407 Charleston -
·From: Highway 17 North of Charl Cross the Cooper River Bridge and continue on Highway 17 through downtown Charleston. The road turns into Savannah Highway, hotel is on right three miles from Ashley River Bridge - look for the palm trees and our famous tower ·From: Highway 17 South of Charl Entering Charleston area on Highway 17 you will go underneath Interstate 526, after the overpass the hotel is three miles on the left side of the street - look for the palm trees and our famous tower ·From: Interstate 26 West of Cha When entering Charleston area, take Interstate 526 exit towards Savannah in North Charleston, continue to the end of Interstate 526 and make a left at the end of the highway which will be Savannah Highway. The hotel is three miles on the left side Savannah Highway - look for the palm trees and our famous tower., Local Attractions:, Local Attractions:, Transportation:, Local Attractions:, Local Attractions:, Local Attractions:, Local Attractions:, Local Attractions:, Transportation:, Shopping:, Shopping:, Shopping:, Shopping:, Recreation:, Recreation:, Recreation:, Recreation:, Transportation:, Transportation:, Transportation:, Education:, Education:, Transportation:, Education:, Education:, Nearby Cities:, Recreation:, Local Attractions:, Corporations:, Local Attractions:, Shopping:, Shopping:, Transportation:, Transportation:
- 7,47 km
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Award-winning hosts Ant and Dec cook up their most ambitious Undercover to date on Ant and Dec's Saturday Night Takeaway as they wind up Gordon Ramsay.
Chef Ramsay was left itching to seek revenge after been duped by the pair who dressed as handymen, flew to LA and caused havoc on the set of US MasterChef.
In full make-up and prosthetics it doesn't take much behind the scenes banging for the renowned potty-mouth star to reel off a few classic words.
"Who is that c*** behind that wall out there?" Ramsay shouts as the pair stop him completing a clean take.
In the video above Ramsay says that he is having a "f****** nightmare", have a watch to see the look on his face.
Click here to see Ant and Dec's 10 funniest pranks from Saturday Night Takeaway, featuring One Direction, Simon Cowell and Girls Aloud .
* Ant and Dec's Saturday Night Takeaway returns for the second episode on March 1 at 7pm on ITV


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Naked Teas GaloreEdit Company
Popular Teas from Naked Teas GaloreSee All 24 Teas
Recent Tasting Notes
The leaf is really pretty with what appear to be rose petals and floral dry bits.
A bit of a citrus scent to the brew, but a sort of generic mixed sweet spice flavour. The woody rooibos tails behind despite me having steeped it with cooled water.
I'll drink what I have, but I don't need to seek out more. More doesn't appear to be available anyway on the site. I tried to find the tea information to enter in Steepster, but it is all gone without a trace.
Flavors: Citrus, Spices
This is probably the most disappointing thing in my cupboard. I'm not huge on rooibos, but I wanted to find a good decaf drink, and I love red velvet cake, so I thought this would be great.
Unfortunately, it doesn't taste like red velvet cake at all. I steeped this according to the instructions on the package (and even overleafed a bit) but it still doesn't taste like much of anything. I'm kind of irritated that I can't even use it in baking because the flavour is so minimal that I might as well be using plain water anyway.
Edit: I tried again with 2tbsp/1 cup for 10 minutes and it mostly just tastes like plain rooibos and irritatingly tart hibiscus.
This is the first tea that I tried from Amoda Tea's "holiday tasting set". And it's not at all what I would have expected from a tea called "Candy Cane"! Not at all! And I mean that in a very good way!
This is not your average candy cane tea. It's minty (like a candy cane) but that's where the comparisons end. The mint is balanced out with notes raspberry, hints of cinnamon, and notes of jasmine and rose. I know … not your average candy cane! This is more like a candy cane you might find in a gourmet, artistic candy shop.
The mint isn't overpowering (the way it often is in a candy cane blend), and the cinnamon contrasts with the minty flavor just enough to keep it from tasting mouthwashy. The floral notes are subtle but keep things interesting. The green tea base is soft and fresh, and there is a hint of nutty flavor from the rooibos.
Here's my full-length review of this tea – it's really quite an interesting tea! http://sororiteasisters.com/2015/01/04/candy-cane-tea-from-naked-teas/
Queued post, written August 19th 2014
MissB shared this one with me, although I'm afraid it's not going to be something for me, really. It has spearmint in it, which I tend to find rather too toothpaste-y and also jasmine which I plainly just don't like. So… But I shall try to keep an open mind!
I have to say, I don't find it a very nice smell. It reminds me mostly of soap, which I believe must be because of the floral element. I'm not keen on flowers on my tea, and to be honest, I'm generally not keen on flower-smells in general. Not even actual flowers. Sometimes people around me can go 'ooooh doens't that smell lovely?!' and I'll sit quietly to myself thinking it stinks to high heaven. Geraniums fall into that category for me. We have some outside and they are forbidden entry to the house on account of reeking. Blech and blech again, says I!
So flower perfume? Frequently not going to score many points with me.
After a bit the flower perfume and soapy associations go away though and it smells more minty. Primarily spearmint, unfortunately, but I can also pick up the green tea and the rooibos underneath.
To my relief, I can't actually taste the jasmine much. There is a bit of it around the edges that I don't much like, but it's not bad. There is a great deal of mint, particularly spearmint, but that was to be expected with a name like that.
Apart from that I can pick up the green and rooibos again, and also a bit of cinnamon, particularly on the aftertaste. Rose and rosehip seems pretty much absent, but that doesn't bother me.
I'm getting a slightly messy feeling from this. Mint, floral and cinnamon. Not things I would have thought to put together. The combination strikes me as a bit odd. I could have taken mint and floral on their own (logically, I probably wouldn't have liked it) or mint and cinnamon on their own. I could even imagine floral and cinnamon on their own. But all three together? It seems a little bit of a jumble to me.
It's far more drinkable than I had anticipated, but I won't cry over the fact that I can't have it again.
Whoa. The dry leaf smells just like black cherry soda! Brewed, the scent is a rich, creamy, chocolate with a sheen of Maraschino cherry. But the flavor doesn't quite live up to the scent. There's no chocolate! There's dryness and a heavy mouthfeel, but no particular taste until a lingering Maraschino cherry note comes in at the end. When the tea cools, it just tastes like flat black cherry soda. I have real black cherry soda in the fridge, thank you very much (Dr. Brown's, of course). Although… maybe this would be a good candidate for a tea soda. Not an impressive showing so far.
Thanks for this one in your sale, MissB! I've been trying to try more of my teas I haven't gotten around to yet, before I delve into the teabox, to get a better handle on what to add to the teabox. I will start on those soon! I thought this would be like Joy's Teaspoon Almond Cookie (ESP emporium also has a blend similar/same). It is slightly, but not quite and not as those blends. Almond Cookie is mostly almonds, apple, cinnamon and beet root to give it a lovely pink color. This one has some other ingredients: brazil nuts, & cocoa nibs (with the apple, chocolate sounds like a weird combo.) The color of this cup was not pink, so I don't think there is beet root. This blend tastes more apple than cookie/nutty so I don't think it actually is "nutty enough". I couldn't really taste any chocolate in the blend, even using more than two teaspoons and steeping for quite a while. It really just seems like apple. It's an okay blend, but the Almond Cookie is pure perfection!
dexter sent this one my way…this one was a straight up miss for me. It didn't remind me of black forest cake or taste even remotely like it. It was just sort of there…hanging out. oh well! can't win them all and i love trying ALL THE TEAS! except for that blergamot one that james is threatening to make and send me… ick.
Thanks Scheherazade for sending me this one.
I love nutty teas, especially when it's the only flavour and it's not masked by other flavours. Unfortunately, I didn't find this terribly nutty. I could detect a hint of almond now and then, but for the most part it was just a sweet black tea.
Thank you Kat_Maria for sharing this with me. Unfortunately, I am finding this one a bit bland. It is mostly black base, though a bit of the cherry flavor does come out as it cools.
I was excited to try this tea from my Amoda January box because of the name. I was thinking the chocolate and cherry cake … and then I started reading the ingredients: carob? eww. Why carob? Why not cacao nibs or cacao shells? Carob is the cheap alternative to chocolate. I don't like carob. I like chocolate.
So, after reading that this had carob in it, I was less excited. But I still tried it.
It's not as bad as I thought it would be given that there's carob in it. It's actually alright. The chocolate notes are a little weak … that's kind of a standard complaint of mine when it comes to chocolate teas though isn't it … and even though it is kind of a standard complaint of mine, I can't help but think it would be better if it had cacao shells or cacao nibs. The cherry notes come through nicely.
I like the rose and the juniper in this … they added a nice dimension of flavor to the cup.
This wasn't what I expected, but it wasn't all that bad. It could have been better, though.
I love carob cookies from a local health food store, and carob chips in other cookies, Carob shake with almond milk is awesome! but havn't had any more luck with liking it in tea so far, like chocolate.
My Hubby is into fruit teas and has been looking for a good blueberry. We had one a few years ago when we bought him a bag of loose leaf on a whim, it was a blueberry rooibos blend. The company now only makes their blueberry version w/a black base.
This one smells nice as a dry leaf… sweet and fruity, not sure I can pick out blueberry.
I wasn't with him when he steeped it, so don't know if he followed directions well. He drank about 3/4 of the cup and even tried a bit of sugar, which isn't his normal, and he was ready to discard the last bit.
I offered to try it and see what he was tasting. To me, there was a berry flavor, but mostly hidden beneath the green tea flavor, and it seemed to have a thick mouth feel. I think this may be one of the first fruit flavored green teas that he has had. He has had plain greens at restaurants before, so he's familiar with the flavor.
I'm going to hold off on rating this one until I have a chance to try it & be sure it is steeped correctly and see where we are after that.
He did try a blueberry blend from American Tea Room after trying this one and it was received much better (can't get Steepster to let me review it, so I'll try it later). Still not quite what he had before.. but closer.
Thanks MissB for sending these one our way for him to try!
Backlog (from this past week). Apparently I took poor notes the last time I drank this, and wasn't much better this time, although I did write down that I was picking up a bit of an artificial cherry note that I found to be unpleasant. It looks like I previously thought this was ok, but I wasn't overly fond this time. Oh well!
Second tea from Amoda's January 2014 box. I didn't take great notes on it, but what I do remember is a definite cherry flavour, different from cherry blacks I've had previously. I'm not a big fan of maraschino/candied cherries (which are the types of cherries I associate with black forest cake), but I'm not quite sure it tasted like that… anyhow, I'll have to give it another shot and pay a bit more attention! At the very least, I remember it being ok? Haha.
I'm typically not all that excited to try "detox" teas or other functional type teas because, well, their functional. Functional usually = not tasty. But as far as functional teas go, this one wasn't too bad. It actually turned out to be tastier than I expected it to be.
It didn't really taste medicinal or overly herbaceous to me (which is usually what I expect from a functional tea like this.) The spices gave it more of an appealing spicy taste rather than a medicinal one.
A warm, zesty tisane with notes of herb. Not bad.
This was good, a little subtle in terms of not being overly sweet, and I loved the true flavor of the cherry, how it really was the specific cherry in a black forest cake smell. That said, something felt missing. I don't know what though. I had it last night (I've developed a habit of trying new teas at night but not reviewing them until the next day which makes for shoddier notes I reckon but is worth it to be able to focus on reading and Buffy) and I can't remember if I had any guesses then…perhaps body? Not quite thick or silky enough? Hm. Not sure.
100th Tasting Note!
I had a cup of this yesterday and was a little disappointed. I know I underleafed because I wanted to make sure I got a few cups out of the sample, but the flavour was very weak. I tried it again today and made sure I put in the correct amount of tea, and what a difference! I really enjoyed this. The cherry flavour is stronger than the chocolate but I think that is a good thing. I find cherry teas are fairly uncommon and it was nice to have a cherry black as opposed to a green. I don't know if I would buy this again, but I might down the road if I'm craving a cherry black.
So this was in my Amoda box last month and I' just finishing it up now. It's sweet, has cherry flavouring and some other things, but I'm not enthused about this one guys.
Not really. It's ok. It's a happy face, but not a really happy face. There's no tongue sticking out begging for another drop face here.
So there's something in this that I just don't care for. I can't put my finger on it. It's also the same flavour I noticed in Butiki's Raspberry Truffle, and that I think was also in her Rhubarb Vanilla Ale or Ruby Pie. (one of them). It's dark, a little bitter and … salty, for lack of a better word.
If I can ignore it, this tea is fine. If I can't, it's not so great. I'll resort to a dash of milk then.
Still. I wish I could figure out what it is. Am I just sensitive to some random flavour? :P
I haven't been very much into green teas recently. Partially because, as I recently discovered, I had been steeping them at too high temperatures. I have recently corrected that and I am ready to go on a green tea adventure again.
This one has exceeded my expectations. It is so extremely blueberry-ish that I am not sure how they achieved that without artificial flavoring. This very strong blueberry flavor composes wonderfully with the green tea base and doesn't seem to overpower it (somehow!). I love it!


text:
Vehicle break-ins over weekend; watch for suspicious persons
Stay on the lookout: Franklin Police say a rash of vehicle burglaries over the weekend may be connected to an SUV seen in the area.
Police Chief Sabria McGuire said reports started flowing in late Thursday and Friday morning. They continued through the weekend.
A silver SUV was spotted and is possibly connected to the burglaries.
The perpetrators are breaking windows to get into the vehicles.
Burglaries have occurred in the areas of Lee, Canal, Oak and Magnolia streets. At least six have been reported.
McGuire asked residents to keep alert and report suspicious activity. Police received one reported of an individual walking from house to house in the area.
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text:
Activated cells in human coronary atheromata express high levels of matrix-degrading enzymes, e.g., collagenases and elastases. Our previous studies suggested that such collagenolytic and elastolytic activities regulate the integrity of diseased arteries. A series of recent studies supported by this NIH R01 provided the direct in vivo evidence for the important role of collagenolytic enzymes of the matrix metalloproteinase (MMP) family in arterial remodeling. This renewal application proposes to examine further the effects of genetic and pharmacologic manipulations of collagenases on plaque collagen metabolism, and to study in depth the role of elastolytic enzymes in arterial disease. We will also explore the possibility of detecting matrix degradation using biomarkers.
Specific Aim 1 will complete our studies of the roles of various interstitial collagenases in the regulation of the structure of atherosclerotic plaques in mice. We will examine the effects of deficiency of another collagenase MMP-8 on plaque structure. We will further analyze collagen structure in atheromata of the compound mutant mice lacking two major collagenases MMP-13 and MMP-8. Studies using a novel imaging technology and an MMP-13 selective inhibitor will test the hypothesis that pharmacologic inhibition of this collagenase will alter the plaque structure.
Specific Aim 2 will test the hypothesis that mice with combined deficiency of apoE and Niemann Pick disease, type C1 (NPC1) protein will show heightened susceptibility to arterial ectasia. As compound mutant apoE- and NPC1-deficient mice overexpress cathepsin K, a potent elastase, we will track cathepsin activity in vivo in these animals by molecular imaging. We will also image and characterize the structure of elastin in arterial tissue from these manipulated mutant mice.
Specific Aim 3 will develop and validate biomarkers of extracellular matrix protein degradation to provide novel tools to probe elastin and collagen degradation in vivo. These markers will include MSGC measurement of post-translationally modified amino acids and their condensates that serve as signatures for elastin and collagen breakdown. Exploration of the in vivo utility of novel markers of elastinolysis will use biological specimens derived from mice with mutations in various elastases including cathepsins K and S, MMP-9 and -12, and neutrophil elastase, as well as from mice with genetically-induced cardiomyopathies. If we succeed in developing and validating novel biomarkers, we will apply them to banks of blood specimens on patients in various large clinical trials conducted at our institution to test the hypothesis that the interventions (e.g. mineralocorticid receptor blocking agent or statin administration) affect matrix metabolism in humans in vivo.
Collagenolytic and elastolytic activities in human coronary atheromata likely regulate the matrix structure of atherosclerotic plaques, a key determinant of the acute thrombotic complications. Our recent studies supported by this NIH R01 provided the direct in vivo evidence for the important role of collagenolytic enzymes. This renewal application proposes to examine further the effects of pharmacologic and genetic manipulations of collagenases on plaque collagen metabolism. We also propose to study in depth the role of elastolytic enzymes in the pathogenesis of arterial disease. In addition, we will explore the possibility of detecting matrix degradation using biomarkers. This project should help in understanding the mechanisms of arterial remodeling during atherogenesis. These complementary studies will translate further preclinical findings into clinical preventive cardiovascular medicine.
|Chatzizisis, Yiannis S; Blankstein, Ron; Libby, Peter (2014) Inflammation goes with the flow: implications for non-invasive identification of high-risk plaque. Atherosclerosis 234:476-8
|Folco, Eduardo J; Sukhova, Galina K; Quillard, Thibaut et al. (2014) Moderate hypoxia potentiates interleukin-1? production in activated human macrophages. Circ Res 115:875-83
|Wang, Jing; Lindholt, Jes S; Sukhova, Galina K et al. (2014) IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. EMBO Mol Med 6:952-69
|Libby, Peter; Tabas, Ira; Fredman, Gabrielle et al. (2014) Inflammation and its resolution as determinants of acute coronary syndromes. Circ Res 114:1867-79
|Heusch, Gerd; Libby, Peter; Gersh, Bernard et al. (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383:1933-43
|Rocha, Viviane Zorzanelli; Folco, Eduardo J; Ozdemir, Cafer et al. (2014) CXCR3 controls T-cell accumulation in fat inflammation. Arterioscler Thromb Vasc Biol 34:1374-81
|Hilgendorf, Ingo; Theurl, Igor; Gerhardt, Louisa M S et al. (2014) Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation 129:1677-87
|Taqueti, Viviany R; Di Carli, Marcelo F; Jerosch-Herold, Michael et al. (2014) Increased microvascularization and vessel permeability associate with active inflammation in human atheromata. Circ Cardiovasc Imaging 7:920-9
|Quillard, Thibaut; Araújo, Haniel Alves; Franck, Gregory et al. (2014) Matrix metalloproteinase-13 predominates over matrix metalloproteinase-8 as the functional interstitial collagenase in mouse atheromata. Arterioscler Thromb Vasc Biol 34:1179-86
|Libby, Peter; Lichtman, Andrew H; Hansson, Goran K (2013) Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity 38:1092-104
Showing the most recent 10 out of 39 publications


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Publisher's Description+
From MoSync AB: The iOS Client for the MoSync Reload is a companion application to view apps developed with MoSync Reload.MoSync Reload helps you develop apps the same way you would do with web browsers, by just hitting the Reload button. For more information, see http://www.mosync.com/reload
What's new in this version:
* Reloading from your server directly on the ReloadClient (Local Networks only)* Now the Reload client can automatically find the server in your local network.
read more +


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Rates in SGD (taxes & fees included), shown as:
Nightly Average
S$201 Avg. price/night
Punta De Fabian
Manila East Road Barangay Evangelista, Tanay, Manila Baras, Philippines
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Check-in: 15:00
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This 3 star hotel is located within the city of Baras. The Hotel has an outdoor swimming pool.
Manila East Road Barangay Evangelista Tanay, Manila Baras, Philippines


text:
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Can't find the item you are looking for using the search and browse tools above? View our special order catalog.
Be faster. RockShox's BoXXer has been on the downhill circuit for almost two decades and has amassed countless World Cup victories. With a massive 200mm of linear, coil-sprung travel and an impressive weight of just 6.5 pounds, this big fork devours every course with smooth, stylish speed. This race-bred beauty features RockShox's Motion Control IS damper to suck up everything from braking bumps to road gaps. The BoXXer also has RockShox's 20mm Maxle Lite DH through-axle and big 35mm Fast Black stanchions. Combined, this chassis has the stiffness you need for surgical steering precision to hold the tightest lines on any track.
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Alexandria Annandale Balmain Baulkham Hills Bondi Bondi Junction Castle Hill Chatswood Coffs Harbour Coogee Cronulla Darlinghurst Dee Why Epping Glebe Harbord Hornsby Lane Cove Manly Mosman Neutral Bay Newcastle Newtown North Sydney Paddington Parramatta Pyrmont Randwick Surry Hills Sydney
Below is a selection of search results matching: NLP New South Wales
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Clinical Hypnotherapy
Sydney, New South Wales
Hypnosis is a perfectly natural state in which someone's conscious mind is relaxed and their subconscious mind is receptive to making...
02 8074 0089
Gordon Young - The Mondo Clinic
Sydney, New South Wales
Don't waste another day! The problem has a solution. Gordon Young is an Internationally recognised name in the world of NLP and...
02 9977 79 00
Haberfield Health
HABERFIELD, New South Wales
No matter what type of natural health care you're after, we here at Haberfield Health are the ones to call. We offer world-class...
Haberfield Health - What we do
02 9797 0422
Glebe Healing Centre
Annandale, New South Wales
No matter what ails you, we here at Glebe Healing Centre have the perfect natural treatments. From Life Coaching to Ear Candling, our...
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Mind Mechanics PTY LTD
Sydney, New South Wales
The field of Hypnosis is moving and evolving quicker than areas of contemporary living such as IT. Hypnosis is an extremely effective...
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Tangible Results
Abbotsford, New South Wales
Are you facing some sort of challenge that you don't know how to move through on your own? Emotional Freedom Techniques & Matrix...
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Alchemy Psychology Services
Byron Bay, New South Wales
The skilled team here at Alchemy Psychology Services, specialises in providing a range of professional Counselling & Psychology...
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07 5536 5838
Mind Advantage - Experienced Psychologists and Counsellors
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Do you suffer from anxiety? Is your relationship not flowing as you would like it to? Do you feel like you are at a...
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Hypnosis Newcastle - Brett Cameron by Cameron Hypnotics
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CAMERON HYPNOTICS IS NOW OPEN at THE JUNCTION. 5 Days a Week * Quit Smoking Hypnotherapy * Weight Loss Hypnotherapy * Stress and Anxiety...
Brett Cameron
0403 335 751
0403 335 751
Cherie Richey-Lowe Hypnotherapist
Castle Hill, New South Wales
Hypnotherapy and NLP can assist in a wide range of issues from Weight issues, Quit Smoking, Anxiety, Phobias, Self Improvement just to...
Cherie Richey-Lowe
0422 547 678
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text:
[Letter from David Fentress to his wife Clara, May 7, 1865]
Description: Letter from David Fentress to his wife Clara regarding her wool, his cold, and the losses of their peach trees and grapes. He requests that she send bucket butter at the first opportunity.
Date: May 7, 1865
Creator: Fentress, David
Item Type: Letter
Partner: UNT Libraries Special Collections


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- GABA—an amino acid that helps different parts of your brain communicate with each other; it may also help calm your mood by reducing anxiety and stress' which might allow you to focus better.
- L-Theanine—an amino acid that helps stimulate your body's production of serotonin' which is a "feel good" brain hormone that promotes a sense of calm and wellbeing.
- COQ10—a powerful antioxidant that may help protect your brain from damage caused by free radicals (harmful molecules) and toxins.
- Bilberry extract—an antioxidant that may prevent free radical damage to the brain.
- Vitamin C—needed for neurotransmitter regulation; also aids in producing norepinephrine' which is responsible for the transport of nerve impulses between neurons.
If you have trouble concentrating and focusing on tasks' your brain may need a nutrient boost. Your brain relies on a variety of vitamins' minerals' amino acids' and antioxidants to function properly. If your brain doesn't have enough of these substances' you may notice that your attention span and ability to concentrate aren't as strong as they once were.
You can ensure that your brain gets what it needs by eating a well-balanced diet that's low in processed foods and containing plenty of fresh fruits' vegetables' whole grains' and proteins. Since this is easier said than done' a supplement like Biogenesis Nutraceuticals' Focus Fizz can help. This powder has been designed to support brain health at all ages. Some of the ingredients in each scoop include:
To prepare one serving of Focus Fizz' just mix one scoop of powder into four to six ounces of water or juice. The recommended daily intake for children ages three to five years is one serving daily; for children from six to eight years old' serve one-and-a-half servings daily. Children 10 to 14 years old should take two servings daily' while older teenagers and adults can take two or more servings daily.
Biogenesis Nutraceuticals offers unique formulations of supplements with high quality ingredients. They use the latest clinical research to provide patients with the best possible tools for getting and staying healthy. Biogenesis Nutraceuticals believes patients deserve high quality and contaminant free products. Since 2000' they have been focused on making patient compliance one of their top priorities.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose' treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 Scoop (5 Grams)
Servings Per Container: 30
Amount Per Serving / % DV
Calories 5
Total Carbohydrate 3g / 1%†
Dietary Fiber 2g / 8%†
Vitamin C (From Ascorbic Acid) 200mg / 333%
Folate (From (6S)-5-methyltetrahydrofolic acid' glucosamine salt) 400mcg / 100%
Vitamin B-12 (From methylcobalamin) 100mcg / 1'667%
Sodium (From sodium bicarbonate) 100mg / 4%
FOS (Fuctooligosaccharides) 1'000mg / *
Malic Acid 400mg / *
GABA (Gamma-Aminobutyric Acid) 250mg / *
L-Theanine 100mg / *
Citric Acid 80mg / *
Rhodiola (Rhodiola rosea) (Root Extract) (3% Rosavins' 1% salidrosides) 30mg / *
Bilberry (Vaccinum myrtillus) (Fruit Extract) 21mg / *
Phosphatidylcholine (Soy) 17.5mg / *
Phosphatidylserine (Soy) 10mg / *
Coenzyme Q10 10mg / *
R-Alpha Lipoic Acid (From R-Alpha Lipoic Acid sodium salt) 5mg / *
†Percent Daily Values based on a 2'000 calorie diet.
*Daily Value not established.
Other Ingredients: Polydextrose' natural grape flavor with other natural flavors' luo han guo (momordica grosvenori) juice concentrate' stevia (leaf extract)' silica.
Use only as directed. Mix 1 scoop (5 grams) into 4-6 ounces of water or desired beverage.
- Ages 4-5: Take 1 serving daily.
- Ages 6-9: Take 1-2 servings daily.
- Ages 10-14: Take 2 servings daily.
- Age 15 and older: Take 2-3 servings daily.
Do not use if safety seal is broken or missing.
Keep out of reach of children.
Keep your licensed healthcare practitioner informed when using this product' especially if pregnant or nursing.
Keep tightly capped and store in a cool' dry place.
Ratings & ReviewsReview This Item
Overall Rating for Focus Fizz™ - 5.29 oz (150 Grams)
Displaying reviews 1-3 of 3
By Heather
from Yakima,Washington
It works!
My son takes Focus Fizz by Biogenesis Nutraceuticals twice a day and it really works I can tell the difference when he hasn't had his focus fizz.
√ I would recommend this item to a friend.
By C. McFarland
from Seattle, WA
Focus Fizz
Focus Fizz was recommended by my daughters Naturopath to be able to be more focused in school. I put it in her smoothy in the morning with other healthy ingredients.
√ I would recommend this item to a friend.
By Dana
from Wisconsin
Works well but the fizz gives my daught
Focus Fizz was recommended by a naturopathic doctor for my 1st grader and her grades improved and her homework became much easier. Id like to find a similar product because this stuff gives her a terrible tummy ache.
Helps get the homework done and learning at school goes well when naughty boys distract the class.
Fizziness give a gut ache.
√ I would recommend this item to a friend.
Displaying reviews 1-3 of 3
Questions About This ItemAsk a Question
Displaying questions 1-1 of 1
Melody Malouf
on 7/08/2015
Is this product available in an unsweetened and unflavored form? It needs to be!A
on 7/09/2015
Thank you for reaching out to us, Melody. No, Biogenesis does not make this product in any other formulas. We will bring this request to their attention. Hopefully it will be something they can formulate in the future :)
- PureFormulas on 7/09/2015
Displaying reviews 1-1 of 1


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|Message view
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|"Johnson, Garrett" <Johns...@cbsnews.com>
|Apache HTTPD 2.0 / Tomcat 4.1 Workflow?
|Mon, 16 Dec 2002 16:18:44 GMT
I'm curious: What is the workflow sequence when one has Apache and Tomcat running together? Assuming an environment of: Apache 2.0 (@ port 80) Tomcat 4.1 (@ port 8080) mod_jk 1.2 (ajp 1.3) Win2K Pro I understand that that Apache is listening at a particular location, (let's assume for the purposes of this discussion that it's at port 80,) but after it recieves the HTTP request, where does it send it? Which lines in the config of Apache and jk moderate which requests get intercepted and where they go? Once it gets sent off, who recieves the request at that point? Tomcat? JK? If it's Tomcat, where does Tomcat recieve it, before or after _IT_ does it's <servlet-mapping> directives? I'm trying to _understand_ the workflow, since most other cases just involve someone giving just a specific example that doesn't necessarily cover all arbitrary cases. What I'd really LOVE to see is some sort of logical decision diagram, such as: ---------- ---------- -------- -------- |Apache | |JK | |Tomcat| |Apache| |Decision| ---> |Decision| ---> |Output| ---> |Output| ---------- ---------- -------- -------- Complete with diamond if-then-else decisions and references to what config settings moderate each decision. This is a bit much to ask, but I think if it _could_ be done, it'd be super-useful, not just to me but to everyone using Apache, Tomcat, and mod-jk. Thanks in advance... -- To unsubscribe, e-mail: <mailto:firstname.lastname@example.com> For additional commands, e-mail: <mailto:firstname.lastname@example.com>
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Medieval Good vs. Evil Chess
In Stores
This is my first project submitted to the CUUSOO... a chess game with a Castle - Kingdom Knights theme that teaches kids/teens about strategy and planning ahead in a fun way. Instead of having all the mini-figs look the same like any other Lego chess, each mini-figure has its own distinction in facial expressions, color, weapon, and/or armor for better replay value. Good side is obviously more vibrant than the evil side, so when playing a friend of yours, you can set a rule - winner plays good and the loser plays evil!
With this set, you get different assortments of faces, weapons, armors, headgear, and cloaks for your clans.
Close-up of the red knight! An elevated tower can be added below the brown-gray bowman/archer (rook). Holy white magic-user/cleric (bishop) with a gray spell-book. All good soldier pawns carry either a spear or halberd with a rounded white shield. King has gold armor and crown helm with a yellow robe.
Atlantis blue knight on the other end with tower archer with crossbow and green elemental magic-user/geomancer (bishop) with a brown spell-book.
Evil side are skeletons and the undead with mix of red, dark/light gray, dark brown, and black colors. Bat hell knights ride on undead winged horses with huge horns. Brown rot warlock (bishop) uses decay/disease magic from a red spell-book. Evil soldier pawns use two-handed axes and long pikes with angular shields.
More pictures will be added if requested. Add any comments that you think would help improve this project. Thanks for looking!


text:
Showing results for "Gluman Dinner Set 12 Piece Square Red". Did you mean Gluman Disney Set 12 Piece Square Red
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State Theatre
332 S. Main Street,
332 S. Main Street,Akron, OH 44308
No one has favorited this theater yet
The Bank Theatre (this is one of two Bank Theatres in Akron) was located on 332 S. Main Street (the other was at 16 S. Main Street). This Bank Theatre operated from 1917-1921. Last known as the State Theatre. Treva restaurant's bar is now operating in the building.
Contributed by ReelMovieInfo
Recent comments (view all 1 comments)
TivFan on November 29, 2012 at 7:04 pm
I have a postcard (late 1920's/1930's) showing the State Theatre. The building still exists, as well as the columned building next door. The three structures directly opposite it (on Main Street at East Exchange Street) are still standing.
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SOLD -- 1920s Embroidered Mesh Step-in with Pink and Blue Flowers
This product is unavailable
Exquisite and incredibly rare, this beautifully crafted step-in is a wonderful example of 1920s lingerie at its finest. Embroidered with darling pink and blue flowers, this vampy little number is French seamed and adorned with two-tone silk ribbon straps and a soft black silk gusset. Straps are not adjustable and measure 15 inches front to back.
Bust: 37"
Waist: 36"
Hips: 44"
Length to gusset: 32"
Label: None
Condition: Excellent-Pristine
Please view our Condition Chart for additional information.
** A note regarding step-ins. There are no snaps or other openings. Wearer must "step in" through the neck. This means the wearer's hip measurement must be smaller than the bust and waist measurements. Step-ins are meant to be worn baggy and not fitted. **


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The major goals of this project have been to advance genetic and molecular based knowledge of hypoxia induced gene and protein regulation to understand tumor progression and develop more targeted therapeutics for solid tumors. The four projects and two cores that comprise this grant explore how to protect normal tissues to increase the efficacy of hypofractionated and fractionated radiotherapy, and how to specifically increase tumor radiosensitivity by manipulating mitochondrial metabolism and the unfolded protein response pathways. These projects represent a highly integrated effort to translate our understanding of the biology of hypoxia and metabolism to enhance the efficacy of radiotherapy. The first two projects, Project 1 (Project Leader: Giaccia) and Project 2 (Project Leader: Le), wil attempt to mitigate the effects of radiation on the Gl tract and submandibular glands through the exploitation of the PHD/VHL/HIF pathway and metabolic activation of aldehyde dehydrogenase (ALDH3A2). During the last grant period, Project 1 (Project Leader: Giaccia) was focused on the role of CTGF and Lysyl Oxidase in pancreatic growth and metastasis. This project has been quite successful and resulted in a Phase I clinical trial for anti-CTGF in pancreatic cancer. Similarly, Project 2 (Project Leader: Le) has focused her project on using activation of ALDH3A2 to protect and mitigate radiation-induced toxicity to the submandibular gland. This is a new direction from the last submission where she was highly productive in understanding the role of hypoxia induced Osteopontin (OPN) on tumor growth and metastasis. Project 3 (Project Leader: Denko) and Project 4 (Project Leader: Koong) are continuations of the projects from the last grant period and will investigate how manipulating mitochondrial activity and the UPR pathway will increase radiosensitivity and work cooperatively with radiotherapy to control tumor growth, respectively. Both of these projects are also highly translational and have had significant achievements during the last funding cycle. In the competitive renewal, Project 3 will investigate whether correcting the oxygen supply and demand mismatch through the use of papaverine will increase tumor oxygenation and radiosensitivity. If successful, this molecule, which has already been approved clinically as anti-spasmodic, could rapidly enter clinical trial. Project 4 identifie new inhibitors of the IRE1 endonuclease, which controls one branch of the unfolded protein response, and sensitizes hypoxic cells to radiation. The overall hypothesis to be tested in this PPG is whether manipulating hypoxia response pathways will result in increased tumor control and normal tissue protection.
The concept of therapeutic index has two components: the tumor component and the normal tissue component. However, manipulation of either part of this equation can increase the therapeutic index. This program project grant is focused on increasing the therapeutic index of radiotherapy by reducing radiation induced normal tissue toxicity (Projects 1 and 2) and increasing tumor radiosensitivity (Projects 3 and 4).
|Rankin, Erinn B; Fuh, Katherine C; Castellini, Laura et al. (2014) Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc Natl Acad Sci U S A 111:13373-8
|Kariolis, Mihalis S; Miao, Yu Rebecca; Jones 2nd, Douglas S et al. (2014) An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat Chem Biol 10:977-83
|Taniguchi, Cullen M; Miao, Yu Rebecca; Diep, Anh N et al. (2014) PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med 6:236ra64
|Xiao, Nan; Lin, Yuan; Cao, Hongbin et al. (2014) Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest 124:3364-77
|Sun, Ramon C; Denko, Nicholas C (2014) Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab 19:285-92
|Giaccia, Amato J (2014) Molecular radiobiology: the state of the art. J Clin Oncol 32:2871-8
|Finger, E C; Cheng, C-F; Williams, T R et al. (2014) CTGF is a therapeutic target for metastatic melanoma. Oncogene 33:1093-100
|Kuo, Peiwen; Bratman, Scott V; Shultz, David B et al. (2014) Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Clin Cancer Res 20:5558-69
|Vilalta, Marta; Rafat, Marjan; Giaccia, Amato J et al. (2014) Recruitment of circulating breast cancer cells is stimulated by radiotherapy. Cell Rep 8:402-9
|Razorenova, Olga V; Castellini, Laura; Colavitti, Renata et al. (2014) The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol 34:739-51
Showing the most recent 10 out of 143 publications


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Boom Boom the Label
Get It Jumpsuit
Sold Out
Hand-made from scratch so you know it has gotta be good. Boom Boom The Label created the Get It Jumpsuit with their signature double layered fabric to provide extra support and avoid being too sheer. Jumpsuit hitting below the knee with V-neckline and spaghetti straps detail, available in khaki green and black.
Model is wearing size Extra Small
95% Polyester, 5% Elastane