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Late last week, the United States Supreme Court issued its long-awaited decision in Association of Molecular Pathology v. Myriad Genetics, Inc. The Court held unanimously that full-length wild-type DNA molecules are not patent-eligible under the Patent Act, even when isolated, but are instead "products of nature" that cannot be patented. Importantly, the Court also concluded that cDNAs – DNA molecules in which the naturally occurring non-coding regions (introns) are absent – are patent-eligible. The decision is likely to have wide-ranging impact on the biotechnology industry in litigation, patent prosecution, and licensing.
The challenged claims in Myriad were directed to naturally occurring genes that play a role in breast cancer. The Court held that an isolated, naturally occurring gene or gene fragment was not a new "composition of matter" under § 101 of the Patent Act, because such a gene had all the same genetic information the DNA would have in the body. The Court rejected arguments made by Myriad and adopted by the Federal Circuit that isolating a DNA molecule by cleaving the chemical bonds that join it to flanking DNA sequences is enough to render the molecule patent-eligible.
In contrast, the Court held that cDNAs were patent-eligible because they were "unquestionably … something new." While the Court did not explain its rationale in detail, the justices appear to have reasoned that cDNAs are not naturally occurring and are synthesized from RNA in the laboratory. The Court's reasoning almost certainly validates the patent-eligibility of highly engineered DNAs such as those coding for humanized or chimeric antibodies.
The Court briefly addressed claims drawn to naturally occurring DNA fragments, observing that "very short series of DNA may have no intervening introns to remove when creating cDNA. In that situation, a short strand of cDNA may be indistinguishable from natural DNA." Under this reasoning, a short fragment would not be patent-eligible if it had a wild-type DNA sequence even if it was originally created as part of a cDNA.
At oral argument, the justices evidenced some uneasiness with the finer points of molecular biology underlying the patent issues. In a separate concurring opinion, Justice Scalia expressed his own concerns and refused to join in the Court's scientific discussion, writing, "I am unable to affirm those [scientific] details on my own knowledge or even my own belief."
Because of the highly technical subject matter, the Court appears to have kept its opinion deliberately narrow. Even so, some of the Court's reasoning is less than clear. Most notably, the Court distinguished between "naturally occurring" and "synthetically created" DNAs, despite the fact that DNAs having a naturally occurring sequence can be readily synthesized in a laboratory. The Court specifically expressed no opinion as to the patent-eligibility of inventions directed to "DNA in which the order of the naturally occurring nucleotides has been altered."
The Myriad ruling draws on the Court's previous ruling in Mayo Collaborative Services v. Prometheus Laboratories, Inc., a case that addressed the patent-eligibility of method or process claims. The two cases together expand the Court's previous holdings that "laws of nature" and "products of nature" are not patent-eligible and apply them to the life sciences.
The effects of the ruling going forward are, in a word, myriad.
While the opinion appears to hold that patent claims directed to isolated wild-type genes or gene fragments (and, by extension, other wild-type DNAs such as enhancers, promoters, etc.) are invalid, the decision presents an open field to litigate the validity of claims drawn to:
More generally, the Court did not provide guidance about the extent to which a naturally occurring DNA sequence must be modified to become patent-eligible, nor did it suggest how it would rule on other purified, isolated, or synthesized materials that may have a naturally occurring counterpart. All of these issues are likely to be the subject of future patent litigation.
It will be extremely important to draft claims that clearly differentiate between the claimed invention and any naturally occurring form of the DNA. For example, a human DNA sequence incorporated into a non-human mammalian chromosome may pass muster even if the isolated DNA itself would not (assuming that the DNA meets other requirements for patentability such as non-obviousness). Claims should be directed to plasmids, vectors, transformed host cells, or other constructs including the DNA sequence of interest to make clear that the claims do not encompass naturally occurring embodiments. Patent applicants should take advantage of the Court's ruling that cDNAs are patent-eligible by claiming those, even in isolated form. Where an invention relies on the use of intronic sequences (the sequences omitted in a cDNA), it may be beneficial to disclose and claim non-natural introns such as chimeric introns. The written description should emphasize the differences between the natural composition of matter and the claimed invention. Patent applicants with vulnerable claims should add new method claims about how to create or use the DNAs of interest and should add construct claims, as discussed above. Finally, patentees who no longer have applications pending may seek to narrow and strengthen their claims by initiating reissue proceedings.
Licensors and licensees should review licensed patent portfolios to determine if any licensed patents contain only claims drawn to wild-type DNAs, because such patents may be invalid in their entirety. While the ruling may invalidate some claims of many patents, it is unlikely to invalidate all claims in a patent. Most patents have both broad DNA claims (which may now be invalid) and claims drawn to cell lines, vectors, and chimeric or non-natural mutant DNAs (which are probably still valid).
See more »
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
© Foley Hoag LLP
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Watch The Great Silence
Fans of Spaghetti Westerns may get a kick out of The Great Silence. It is a 1968 movie about a mute gunfighter named Silence. Jean-Louis Trintigant stars in the film. Silence teams up with a group of outlaw Mormons to fight against a group of unscrupulous bounty hunters. The bounty hunters are led by a ruthless character named Loco (Klaus Kinski). The movie is set in Utah during the Great Blizzard of 1899. The struggle for survival leads ordinary people to engage in criminal activities. Bounty hunters appear and terrorize the local population. Silence is hired by a woman to avenge the death of her husband.
| 1968 | 1 hr 45 min | 10 /
- Cast
- Jean-Louis Trintignant, Klaus Kinski, Frank Wolff, Luigi Pistilli, Vonetta McGee
- Studio
- Fantoma
- Director
- Sergio Corbucci
- Language
- Italian

subset: commoncrawl


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Wood/Laminate Literature Sorter, 24 Sections, 39 3/8 x 11 3/4 x 16 3/8, Gray
Versatility and durability come together in this efficient organizer. Cabinet is 5/8" compressed wood with laminate finish. Strong hardboard shelves form 9w x 11 1/2d x 2 1/4h letter size compartments, adjustable in 2 1/2" increments to accommodate books, binders or display items. Black plastic molding complements finish and doubles as a convenient labeling area (labels included). Each hardboard shelf holds up to 15 lbs. Mix and match stackable units. Solid fiberboard back.
Includes 24-compartment literature organizer.


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The first intelligent, gripping thriller in New York Times bestselling author Greg Iles's Penn Cage series.
Natchez, Mississippi. Jewel of the South. City of old money and older sins. And childhood home of Houston prosecutor Penn Cage.
In the aftermath of a personal tragedy, this is where Penn has returned for solitude. This is where he hopes to find peace. What he discovers instead is his own family trapped in a mystery buried for thirty years but never forgotten—the… (more)
Publisher: Signet (September 01, 1999)
Format: EPUB
Page count: 487 pages
File size: 877 KB
Protection: DRM
Language: English


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QT Serial port optimization
- Status Completed
- Budget $10 - $30 USD
- Total Bids 7
Project Description
I have written a small program to read out Serial Data from a ECU using QT5 and QT Serialport . However when i test te software with the ECU i do not always get a response back from the ECU . I tried to use a delay but this only helps partially .
It looks like not every message is received completely . I would need someone to improve the serial portion of my code .
The project is hosted on github :
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When Bono, the lead singer of U2, was asked to speak at the National Prayer Breakfast in Washington, DC in 2006, no one knew what to expect. The same is true when one opens this small yet powerful book. The pages are filled with the words of Bono's speech and with photographs that he himself took on his first trip to Ethiopia in 1986.
Though On The Move is a restatement of Bono's speech, it is also a call to action. It tells the story of how Bono became involved with relief efforts in Africa and how we as Americans can bring about change on the African continent. Bono reports that America currently gives less than one percent of the federal budget to foreign assistance.
As he pointedly states, "Look at what happened in Southeast Asia with the Tsunami. 150,000 lives lost to that misnomer of all misnomers, 'mother nature.' In Africa, 150,000 lives are lost every month. A tsunami every month. And it's a completely avoidable catastrophe."
Bono's words are moving and the reader will be challenged to become a part of the solution for Africa. And readers can begin by simply purchasing the book. All royalties from On The Move are being donated to The ONE Campaign.Powered by Sidelines


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Book profiles centenarian restaurants
MIAMI BEACH, Fla. — Conventional wisdom has it that many restaurants never make it to their first birthday, never mind their 100th.
So it's a little shocking just how many have done not only that, but have thrived well beyond 100 years. Fascination with what sets these culinary centenarians apart is what prompted Rick Browne to dig into American restaurant history, collecting the stories of some of the nation's oldest eateries.
"These places are American culinary history," says Browne, who made it a mission to identify restaurants — including taverns, grills, barbecue joints — that are at least 100 years old.
And his recent book, "A Century of Restaurants: Stories and Recipes from 100 of America's Most Historic and Successful Restaurants," includes the nation's oldest (White Horse Tavern in Newport, Rhode Island, established in 1673), the youngest (the Pleasant Point Inn in Lovell, Maine, opened in 1911), and many in between.
"These old restaurants are serving really good meals, made from scratch, plus they're preserving our culture," he says. "And we can't lose that."
Tallying restaurant centenarians is a tricky business. Browne counted any business that serves food — such as taverns — and came up with more than 250. In 2010, the National Restaurant Association and the Nation's Restaurant News focused on eating establishments (rather than bars and taverns that serve food) and came up with 140.
Further complicating Browne's search, several of the restaurants he found have changed their names over the years. Some have even changed locations after fires, earthquakes or hurricanes damaged the original structures. But that's just part of the history that makes these businesses so fascinating.
Whatever the exact count, the numbers are surprising in part because the restaurant industry has a notoriously short survival rate. More than a quarter of new restaurants close within the first year, and that jumps to nearly two-thirds by the end of three years, according to research by the Cornell Hotel and Restaurant Administration.
And most of that is due to typical industry pressures. Centenarian restaurants have buffeted not only that, but also The Great Depression and multiple recessions and wars.
"These older establishments have track record and history and heritage," said Grant Ross, general manager at The Black Bass Hotel in Lumberville, Penn. "This building has been here for 270 years and people have been coming here to dine, stay and to drink for 270 years. And just because there is a recession that is not a reason to stop."
Why do so many succeed? One often-repeated theme is family.
A majority of the centenarian restaurants have been in one family for decades. Like Joe's Stone Crab in Miami Beach, which was not featured in Browne's book but has been family-owned from the start when it opened as a mom-and-pop fish house. Today, it's a must-stop spot where wearing a bib over fine-dining attire is the norm.
"Has the fact that it's family-owned been a benefit to them? Yes, because people are nostalgic," says Bonnie Riggs, a restaurant analyst with consumer research firm NPD Group. "Why do they succeed when the industry right now is not doing well? Because this place is unique. We know it's pricey, but we are willing to pay for it because we know they will deliver on what we expect. And it's an experience."
Joe Weiss opened a small lunch counter on Miami Beach in 1913 and years later — under a different name and in a different building after a hurricane damaged the original location — introduced the tasty crustaceans to his menu. At 75 cents a plate, they were a huge hit and have been ever since. On a busy night, Joe's serves up nearly 1,000 pounds of stone crabs to some 1,700 customers willing to pay market price for a plate.
Joe's is a fourth-generation family-owned restaurant that treats its customers like family. And vice versa.
"Our customers will tell us when things aren't right and when things are right," said Stephan Sawitz, the restaurant's chief operations officer and the great-grandson of Weiss.
Browne traveled nearly 50,000 miles over a year and a half to compile his list, eating 163 entrees along the way. A few of the 250 restaurants he found have since closed down, he admits.
"If we lose them, we would have lost a lot. All you're going to see is fast food places, yellow arches and red roofs."
His advice for the next 100 restaurants over 100? Don't radically change the menu.
"In a lot of cases, people order a dish that they had one time or another," Browne said, adding that diners return to spots they went to as a child. "It's comfort food that comes with memories."
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Travel door to door
Choose your time of travel
Avoid waiting lists for train/bus journeys
Oneway journey with oneway payment
Pay half of the other vendors
Kundan Choudhary
Dr. Maurizio Lambardi
Ramesh Mathur
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Dr. Jaochim Keller
Charge fare for both sides even for drop
Customers feel cheated by unfair pricing
We utilize our network in multiple cities
We leverage our presence in other cities
We pass on the benefit to our customers
Well known for its spicy culinary food, Kadapa is a city in the South-Central regon of Andhra Pradesh. Located a the banks of Penna river, it offers scenic views with surrounding Palkonda and Nallama hills. The best places to visit in Kadapa are the million years old Belum caves,13th century built Gandikota fort surrounded by hills and deep valleys and Shri Venkateswara Wildlife Sanctuary which nestles over 100 bird species and around 1500 varieties of plants.
Kasauli: Are you looking for a pristine and blissful place in India then Kasauli is the best place, which you are looking of. Kasauli is a combination of shrine and nature's unpredictable beauty of Himachal Pradesh. Famous for Brewery plant, Hawa Ghar, Manki point, lower mall road and upper mall road, Mughal Garden, Sunset Point, Timber Trail resort, Krishna Bhawan Mandir and Shirdi Sai mandir are the some beautiful place to see there.
A preferred but dry mode of travel, train journey kills the fun of stopping by at intervals and viewing the attractions that the route from Kadapa to Kasauli has to offer. Prior bookings and ticket confirmation worries can make travelling a burden. So book Kadapa to Kasauli cab from Wiwigo.com the day you want to take your journey and forget about confirmations and restrictions!
Skip the hassles of a public transport journey by choosing a Kadapa to Kasauli taxi from Wiwigo. Make your journey a life event with your loved ones and your privacy safeguarded. Take a handpicked, secure and GPS enabled taxi with registered drivers to give your loved ones that special journey they deserve. What are you waiting for? Book Kadapa to Kasauli taxi NOW! Because, we make travelling an experience to cherish.


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The widening of a critical spot at Pocono Raceway could cause a traffic jam at crunch time in Sunday's Pocono 400.
The Sprint Cup race will be the first held on the 2.5-mile triangular-shaped track since the removal of a curb in Turn 2 (also known as the "tunnel turn" because it's located above the entrance to the infield). A 15-foot apron was added in place of a narrow strip that abutted the grass and was detested by drivers, whose cars were launched up the track into traffic if a wheel landed too far inside in the center of the corner.
The subtraction of the curb could create a passing lane through a flat and sharp corner, daring drivers to jockey for position through a narrow strip of asphalt whose tricky configuration previously demanded single-file racing.
"It could be pretty interesting in the race," Clint Bowyer said. "When we go off four-, five- or 20-wide on a restart, somebody will be on that apron and probably won't come out the other end. But I'd say somebody will try it."
HALFWAY TO CHASE: Highlights, grades and predictions
GLUCK: What we know halfway to NASCAR's Chase
At the least, the curb's absence should provide a larger margin of error and greater comfort at Pocono, where top speeds approach 200 mph. Bowyer said he once "destroyed the front of my car" after hitting the curb in qualifying and had tiptoed through the section since.
"I hated that curb," the Michael Waltrip Racing driver said. "It scared the crap out of me. You carry so much speed back there and were literally right on it. It felt like a 2-foot curb."
Bowyer and several other drivers in NASCAR's premier series got a preview of the slightly tweaked surface last week during testing.
While surveying the tunnel turn in a rental car, Chip Ganassi Racing's Jamie McMurray initially thought the apron might allow for a new line.
"As different as it looks entering the corner, it really doesn't drive much different," McMurray said. "I think it will give you a bailout area on a restart as that usually gets a little crazy. It will be interesting to see if guys get forced down there on restarts. It's nice not to have the curb there. If you touched it, it would shoot you toward the wall. It's more forgiving; it's better than having that big lump of concrete."
POCONO GRAND MARSHALL: Jonah Hill practices start command
Pocono made the change primarily as part of overall safety enhancements (which also included new SAFER barriers and catchfences on the inside of the track), but it also was designed to give drivers better handling at greater speed.
"I don't think you'll see guys dive-bomb through there, but I'm sure someone, probably in the last three laps, will try to go three-wide," track president and CEO Brandon Igdalsky said. "It's definitely going to enhance the racing through the tunnel turn."
Though Pocono is relatively flat with 8-degree banking in the tunnel turn, the transition from the new apron to the racing surface should preclude its use for most of 400 miles.
"It gives you the opportunity to go low if you're trying to avoid something, where before you'd hit the splitter and probably cause an accident," said Richard Childress Racing's Ryan Newman. "It gives some flexibility, but the groove is still the same."
Follow Ryan on Twitter @nateryan
PHOTOS: 2014 Sprint Cup race winners


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The only way is up for One Direction as the pop group are on track to knock Robbie Williams off the top of the Official UK Albums Chart with the fastest-selling album of 2013.
The boy band's third album Midnight Memories is set to topple Swing Both Ways from the number one spot after selling 145,000 copies in its first three days of sale.
According to The Official Charts Company, Midnight Memories is currently out-selling every other artist in the top five combined.
Gary Barlow's Since I Saw You Last is in second place and Williams' Swing Both ways is in third.
Should the band's album continue to sell at its current pace, Daft Punk's Random Access Memories could be in danger of losing its 'fastest-selling album of 2013' title.
The French duo's fourth album sold 165,000 copies in its first week of sale when it was released in May earlier this year.
One Direction have made multiple TV appearances to promote their new album in the past weeks.
Performances at the MTV American Music Awards, Children In Need, and most recently The X Factor, have helped propel the group towards their second number one.
Right Place Right Time by Olly Murs has climbed 92 places to fourth place following the release of his new single "Hand On My Heart", and Boyzone's twenty year anniversary album BZ20 is at number five.
Susan Boyle's Home For Christmas has debuted mid-week at number seven.
In the mid-week singles chart, "Under Control" by Calvin Harris, Alesso and Hurts looks set to knock Lily Allen's "Somewhere Only We Know" off the number one spot on Sunday.Reuse content


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By now, you should have already read what I assume will be the world's foremost guide on choosing which fantasy quarterback is right for you. Now that we have that out of the way, we can move on to the position that really matters – the running back. In this era of overexposure and mushy brains, almost every NFL team uses some sort of running back system that has made the elite RB as rare as a virgin quarterback.
Most people who arrogantly call themselves "fantasy experts" believe that it is important to draft one of the elite RBs before any other player, and this is the one instance in which I agree with them. But remember, I write these things to offer my honest gut instinct as a guide for beginners and people who rip themselves to shreds with indecision. My humble opinion is that a top RB is worth more to you than any other player on a draft list. However, if you have gigantic testicles, don't let me stop you from going elsewhere.
But if you agree with me that the elite RB is a dying breed, then let's examine which guys are worth a damn and which guys will break your heart.
The Unicorns
This is probably the easiest thing to write in any sort of fantasy football column, whether you call yourself an "expert" or you're like me and you readily admit that this is all guessing and there's hardly any science to it.
Arian Foster – If you have the No. 1 pick (I did) then you can't go wrong by picking Foster (like I did), even if you're worried that him being a vegan somehow hurts his value (it doesn't). He should be good for 100 yards and 1-3 TD per week, which is miraculous in this day and age.
Ray Rice – Thanks to Joe Flacco's "elite" ability to dump the ball off a ton, Rice is a receiving beast, which translates well for PPR. Luckily, he's also an all-around beast, too, so he produces a ton of points. I argued with one friend who said people who would take Rice No. 1 are crazy. I don't think it's too far-fetched.
LeSean McCoy – And I'd argue McCoy could go No. 1, too. I don't think there's too much of a difference between the 3 of these guys. I only think it's a reach to think that McCoy will score 20 TD again, but who the hell knows with that offense?


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Permissions can become confusing in SharePoint. A few basic principles help clear the mist a little. The more complex you allow your permissions structure to become, the less secure and, ultimately, the bigger nightmare it is to administer.
Microsoft Office Training
Business Management Daily provides extensive Microsoft Office help, from Access tips to Microsoft Office templates and much more.
Be sure you're getting the most out of your office technology investment. Our Microsoft Office tips will make you more efficient, more valuable AND even more marketable!
Notebooks can proliferate. So how do you get rid of them?
Here's a summary of how Office Online and Desktop Office 2013 compare, plus a heads-up to the limitations of each.
Bring up a menu of content types within a document library ... Enable uploads within that library ... Dive into edit mode quickly.
Microsoft Office applications have always had the capability to work together. These days, there's much more interoperability than most people use.
You might find that you are repeatedly creating the same type of pages in OneNote. Do this quickly with page templates.
Send unwanted pop-ups or unpredictable results walking when mousing along the bottom of the Desktop ... View icons in the Notification area ... Launch the Control Panel with a shortcut to get things done more easily.
Microsoft Certified Trainer Melissa Esquibel answers three questions about its basics.
The Office app remains a relatively new option for iPad users, but one that can really help you boost productivity when you can't use your laptop or desktop computer.
You can do far more to those images than you think, and all it takes is knowing what to click in MS Office.


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Shoppers who want to avoid the crowds might consider going to the mall Wednesday for a holiday shopping trip.
ShopperTrak, a Chicago-based company that tracks shoppers for 750 leading retail brands, is forecasting Dec. 4 as the least-busy day of the 26-day holiday shopping season.
"There's a reason Black Friday and the Saturday before Christmas attract the heaviest crowds (as) retailers flood consumers with discounts and special offers on those days," said Bill Martin, ShopperTrak founder and executive vice president.
"But quieter shopping days also present their fair share of deals for consumers, along with more attentive customer service and a leisurely shopping experience," he said.
Monday, Tuesday and Friday of next week are also expected to be among the lightest days for foot traffic at stores.
The split of holiday sales is 30 percent on the weekend before Christmas and 10 percent for both the Thanksgiving holiday weekend and the week between Christmas and New Year's, said Anthony Liuzzo, professor of business and economics at Wilkes University in Mesa.
The remaining 50 percent of sales are scattered over the remaining days before Christmas.
Super Saturday, the Saturday before Christmas, is often the busiest shopping day of the year, as it was in 2012, he said.
Finally, there is the Father's Day of holiday shopping, Dec. 23, for men who procrastinate their search for gifts until the penultimate shopping day of the season.
Those who want to avoid crowds altogether can shop online. Bargain specials are set for Cyber Monday, Dec. 2, and Green Monday, Dec. 9.


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Animal models based on genetic manipulations can contribute enormously to our understanding of diseases of the brain. Mutant mice with reduced expression of the Sp4 transcription factor display deficits in sensorimotor gating and contextual learning that resemble putative endophenotypes for schizophrenia. The Sp4 gene is significantly associated with schizophrenia and bipolar disorder. In mouse studies, reduced expression of the Sp4 gene impaired long-term potentiation (LTP) in hippocampal CA1, impaired spatial learning, and markedly decreased the expression of NMDAR1, the core subunit for NMDA glutamate receptors. Impaired NMDA function plays a central role in the pathophysiology of schizophrenia. This identification of a novel Sp4-NMDAR1 pathway provides a basis for cross-species studies related to human psychiatric disorders. This renewal application investigates how Sp4 regulates expression of NMDAR1 proteins to modulate neural pathways involved in sensorimotor gating and cognitive functions. The central hypotheses are that Sp4 post-transcriptionally regulates the expression of NMDAR1 and that restoration of Sp4-NMDAR1 expression in specific brain regions will reverse both sensorimotor gating and cognitive deficits in Sp4 hypomorphic mice.
Four Specific Aims will test these hypotheses:
Aim 1 : To elucidate molecular mechanisms for differential expression of NMDAR1 proteins between wildtype and Sp4 hypomorphic mice. The localization of NMDAR1 mRNA will be examined by in situ hybridization. The differential translation and turnover of NMDAR1 proteins will be examined using TimeSTAMP2.2-Venus tag.
Aim 2 : To reverse deficient sensorimotor gating by restoring Sp4-NMDAR1 expression in excitatory and inhibitory neurons respectively. The expression of Sp4-NMDAR1 will be restored in excitatory and inhibitory neurons of both neocortex and hippocampus, to reverse prepulse inhibition gating deficits in Sp4 hypomorphic mice. Molecular and pharmacological studies will further characterize the conditional rescued mice.
Aim 3 : To determine whether Sp4 hypomorphic mice exhibit cognitive deficits modulated by the frontal cortex, and whether restoration of Sp4-NR1 expression in frontal cortex will reverse these deficits. Both the Attentional-Set-Shifting Task and the Odor Span Task will be used to examine cognitive functions in Sp4 hypomorphic and conditional rescued mice.
Aim 4 : To test whether restoration of Sp4 expression in hippocampal CA1 is sufficient to reverse the LTP and spatial learning deficits in Sp4 hypomorphs. Sp4- NMDAR1 expression will be restored in CA1 by crossing CamK2a-Cre and Sp4 hypomorphic mice. The formation and consolidation of spatial and contextual memories will be examined in the Sp4 hypomorphic mice harboring CamK2a-Cre. The proposed studies will help elucidate molecular mechanisms underlying the modulation of sensorimotor gating and learning, and aid the development of clinical interventions to prevent the down-regulation of Sp4-NMDAR1 pathway in human psychiatric disorders.
The Sp4 gene, which has recently been associated with both schizophrenia and bipolar disorder, codes for an important transcription factor in brain cells that regulates the function of glutamatergic receptors involved in the cognitive impairments in psychiatric disorders. This project seeks to use animal models to elucidate molecular mechanisms related to specific cognitive abnormalities in schizophrenia, in order to aid the development of clinical interventions to prevent the dysregulation of the Sp4-glutamate pathway in human psychiatric disorders.
|Risbrough, Victoria; Ji, Baohu; Hauger, Richard et al. (2014) Generation and characterization of humanized mice carrying COMT158 Met/Val alleles. Neuropsychopharmacology 39:1823-32
|Ji, Baohu; Higa, Kerin K; Kim, Minjung et al. (2014) Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet 23:5683-705
|Kim, Minjung; Soontornniyomkij, Virawudh; Ji, Baohu et al. (2012) System-wide immunohistochemical analysis of protein co-localization. PLoS One 7:e32043
|Zhou, Xianjin; Nie, Zhiguo; Roberts, Amanda et al. (2010) Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Hum Mol Genet 19:3797-805
|Zhou, X; Chen, Q; Schaukowitch, K et al. (2010) Insoluble DISC1-Boymaw fusion proteins generated by DISC1 translocation. Mol Psychiatry 15:669-72
|Oedegaard, K J; Greenwood, T A; Lunde, A et al. (2010) A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11. J Affect Disord 122:14-26
|Zhou, Xianjin; Tang, Wei; Greenwood, Tiffany A et al. (2009) Transcription factor SP4 is a susceptibility gene for bipolar disorder. PLoS One 4:e5196
|Powell, Susan B; Zhou, Xianjin; Geyer, Mark A (2009) Prepulse inhibition and genetic mouse models of schizophrenia. Behav Brain Res 204:282-94
|Zhou, X; Geyer, M A; Kelsoe, J R (2008) Does disrupted-in-schizophrenia (DISC1) generate fusion transcripts? Mol Psychiatry 13:361-3
|Zhou, X; Qyang, Y; Kelsoe, J R et al. (2007) Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice. Genes Brain Behav 6:269-76


text:
Home / handbags & accessories / fashion jewelry /
Fashion Jewelry
Alex and Ani
Alex and Ani Lovestruck Arrow Ring Wrap Gold Tone
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Product information
The arrow signifies clarity of intention and direction. In multiple cultures, it is a symbol of integrity and flight, directed to its destination by the arm of the archer. If the arrow flies true, it makes its mark. Stay focused with your eyes on the target. Let your arrow of intention fly to its goal. Infatuation; Excitement; Wonder


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Louisiana Fire Dipping Glaze For Health Sea Sausages
|3 Ounce (180 Gram)
|Fresh garlic
|15 Milliliter, minced (1 Tablespoon)
|Louisiana hot sauce
|6 Ounce (180 Gram)
|Corn syrup
|30 Milliliter (2 Tablespoon, Light Or Dark)
|Seasoning blend
|1 Teaspoon (5 Milliliter)
Melt butter in saucepan and lightly cook garlic for 2 minutes.
Add remaining ingredients and heat until hot.
Grill salmon sausages brushing glaze on every minute or so for 6-8 minutes.
Sausages should be lightly browned.
Can also be used as Buffalo wing sauce.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1061 Calories from Fat 610
% Daily Value*
Total Fat 69 g106.8%
Saturated Fat 43.9 g219.3%
Trans Fat 0 g
Cholesterol 182.9 mg61%
Sodium 4651.8 mg193.8%
Total Carbohydrates 97 g32.4%
Dietary Fiber 0.88 g3.5%
Sugars 8.4 g
Protein 2 g4.3%
Vitamin A 1029.2% Vitamin C 118.1%
Calcium 10.3% Iron 11.9%
*Based on a 2000 Calorie diet


text:
I just love this Christmas version of our beloved Lindsay Farmer's Market! It's just got everything you need for those last minute 'something special' items! From yummy fresh baked bread by Barb's Home Baking, to delicious sweets and the most incredible coffee, from The Sweet Kitchen. Pat from Deer Run Farm makes the most sinfully delicious jams... you must try her chocolate raspberry jam, if I haven't bought them all, that is! There are Christmas decorations, gifts, clothing, toys, AND
peanut butter dog cookies that our three retrievers will do ANYTHING for!
and finally, the most delicious apples to be found anywhere from the knowledgeable folks from Allin's Orchards!
We all love apples here but no-one loves them like Johnnie does... literally!
So join me and all the great vendors and patrons just like me at the Lindsay Farmer's Market Christmas Market at The Armouries in Victoria Park, Kent Street, Lindsay.
Saturday, December 15 and Saturday, December 22
9:30 am until 3:30 pm
See you there!


text:
"This brilliant, gorgeously written, highly entertaining, and apparently light-hearted idyll quickly reveals its true nature as a powerful and profoundly disquieting meditation on the meaning of loyalty and betrayal, innocence and corruption, truth and deception."
— Francine Prose, Elle
"During one snowy day, I read the whole book in one gulp. It was remarkable, tiny, crazy. I felt just like I did as a kid."
— Andrew Sean Greer, All Things Considered, NPR
"A High Wind in Jamaica by Richard Hughes is like those books you used to read under the covers with a flashlight, only infinitely more delicious and macabre."
— Andrew Sean Greer, All Things Considered, NPR
"Cross a wacky seafaring adventure–Conrad gone awry via inept piracy–with an exploration of the consciousness of a child as radical and insightful as that provided by Henry James in What Maisie Knew, and you have A High Wind In Jamaica by Richard Hughes….By turns funny, ironic, and brutally sad, this is a complex and astonishing novel."—Sue Miller, Barnes and Noble Review


text:
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text:
A few thawing days last week let us get rid of the four-inch-thick
sheet of ice on our drive, but now we've had another four inches
of snow on top of the already thick blanket, and it's been down
into the single digits each of the past two nights. Today is
supposed to get back above freezing for the first time this week,
but more nasty weather is predicted for the end of the week.
I'm really, really tired of this winter.
In a message dated 2/23/2011 7:07:08 AM Eastern Standard Time,
email@example.com writes:
Ha! It's still winter here Got ice and snow yesterday more on Friday.
On Feb 22, 2011, at 6:06 PM, "Johnson, Cyndi D Civ USAF AFMC 95
CS/SCOSI"<firstname.lastname@example.com> wrote:
> The plum tree is in bloom and the buds are showing a little pink on the
> peach trees. I have two or three yellow trumpet daffodils open and some
> of the Erlicheer daffs are starting to bloom. Most of the rest will be a
> while yet though.
> On Sunday's hike we saw some patches of wildflowers; desert coreopsis
> with a few tidy-tips and California poppies. It's not much, but still a
> cheery sight.
> Husband helped me move a ton of compost from the bins into the veg
> garden, at least 25 wheelbarrows full. It's been sitting there for years
> and finally looks rotted enough to use, although there is still
> recognizable hay pieces towards the center. But in this climate, without
> turning it or adding water, that's okay. I rototilled the whole thing
> the next day and have planted my peas. I wanted to push the date up
> again this year but just couldn't get organized. In fact, we were
> supposed to be camping in Arizona with the horses but the weather didn't
> cooperate - we really did not want to chance getting caught in the rain
> out there so we stayed home. It rained Saturday at our house but Sunday
> and Monday were decent gardening weather so I got quite a lot done.
> Next weekend I'll start my tomatoes and peppers in the greenhouse.
> Cyndi
To sign-off this list, send email to email@example.com with the
message text UNSUBSCRIBE GARDENCHAT


text:
1. Hey, you know all that voter fraud the Republicans are citing as the reason behind voter id laws and the like? Guess whose committing fraud? More here.
1.5 That's one reason I'm not counting any chickens before they hatch this election cycle. The other is explained here. I'm fine with dismissing much of what Romney stands for (or doesn't, as it were), but even before his liefest last night (really more of a commentary on Obama's uncertain speaking style than anything good Romney did) I don't want to underestimate him as a politician (although I doubt it's possible to do so as a person).
2. Axl Rose is going to appear on Jimmy Kimmel. You just know that this is going to lead into them doing a recreation of the greatest on-stage meltdowns of all time.
3. Why the video game industry is still seriously messed-up, item #962in a series.
3.5 Here's a good look at the Japanese game industry and the problems with assuming it's all about creepy porn (without dismissing the examples that are).
4. I tweeted this a couple of days ago, but it bears repeating. Bad as some of the responses to social media have been in fandom, they're often worse in academia.
5. Finally, here's how to set up your desk. Anyone who knows me knows that I probably violate every single one of these principles.


text: Nissan Altima: Jalopnik's Buyer's GuideJalopnik Staff10/06/15 12:00pm0EditPromoteGo to permalinkThe Nissan Altima is the C-list celebrity among mid-size sedans. It's really good, but it's overshadowed by giants. What do you need to know before you buy a Nissan Altima? Don't worry, we'll tell you everything right here in our Buyer's Guide.


text:
Region #6, Unit #001
The entire state of Alabama.
Read more: ALABAMA
Region #6, Unit #005
The State of Arkansas has only one Airstream Club. The Arkansas Razorback Unit members reside throughout the state.
Read more: ARKANSAS RAZORBACK
Region #6, Unit #050
We have members located throughout the state of Louisiana. Most are located along the I-10 corridor in southern Louisiana.
Read more: LOUISIANA
Region #6, Unit #029
Members live in the Northwest Fl. and South Al. area. We also have members living in Tx.,Va.,La., Ms.. and other areas . However, we are not limited to this location. We welcome all airstreamers and prospective members.
Read more: PENSACOLA FLORIDA
Region #6, Unit #056
Our members are in all sections of the state. The majority live in the mid-section in or within an easy drive of Jackson.
Read more: MISSISSIPPI
Tweets by @Wally_Byam
WBCCI Central Office803 E. Pike StreetP.O. Box 612Jackson Center,OH 45334Ph 937-596-5211Fax 937-596-5542


text:
Larry Gibson has worked for Case Western Reserve University since 2001. He has held leadership roles in Student Affairs, Finance and Administration, and since 2007, University Relations and Development. As Associate Vice President for University Relations and Development, Larry manages all the division's operations and projects as well as the university's capital campaign and annual fund. Larry is also providing interim leadership to the Weatherhead School of Management's External Relations Office.
Laura Desmond began her fundraising career at Northwestern University, later joining the American Red Cross as associate director of financial development and lead fundraiser on national disasters for the state of Ohio. After serving as vice president for fund development at Applewood Centers,she became a director of development for the Cleveland Orchestra, where she managed a team that raised a record $50 million in 2010. In 2009, Desmond worked with the Maltz Family Foundation to secure the largest philanthropic grant in the orchestra's history, a $20 million endowment gift to create the orchestra's Center for Future Audiences.Desmond spent the early part of her childhood in Hamburg, Germany, due to her father's work as an auditor with Price Waterhouse. She graduated from the University of Michigan with a degree in economics and spent 10 years in Illinois before returning to Cleveland, where her family has roots.
Bernadette Clemens holds a BA from Barnard College of Columbia University and a MA from Case Western Reserve University. She began her Case Western Reserve University career in 2003 in Finance and Administration managing university-wide projects in audit, compliance, fraud investigation, conflict of interest & risk management, and as liaison to the Audit Committee of the Board of Trustees. Subsequently, she became Director of President's Programs managing president's & provost's development, and then Director of Strategic Development for CWRU during the planning years of the current campaign.Not long after President Barbara Snyder was appointed, Clemens became Director of National Development and accompanied President Snyder on numerous national and local development opportunities on behalf of every school at the university as well as president's priorities.Clemens rejoined the university's staff as the Executive of Development at the Weatherhead School of Management in December 2015.
Ann Miller has spent her entire 23-year career in the nonprofit field, including positions in the social service, cultural arts and higher education sectors. Prior to joining the External Relations team at Weatherhead, Miller served as Director of Development for Lake Erie Nature & Science Center, managing all aspects of the organization's comprehensive development program. Her previous experience includes Director of Foundation and Corporate Relations at Notre Dame College, Foundation Officer at Lorain County Community College and Director of Marketing at Applewood Centers, Inc. Miller graduated from Miami University (Ohio) with a Bachelor of Arts degree in English/Journalism and Sociology, and is a proud graduate of the Weatherhead School, earning a Master of Nonprofit Organizations degree. Ann resides in North Ridgeville with her husband and two sons.


text:
Gilliam, MO Rent to Own Homes
|9 Listings Found
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Thanks for visiting and good luck!


text:
Patrice Dumas wrote:
On Thu, Sep 25, 2008 at 03:11:52PM -0500, Matthew Woehlke wrote:Besides; Patrice, your argument is that we should remove functionality that is critical to some users because no one has bothered to fix the /bug/ that by default logwatch sits around filling the spool with large, mostly-redundant messages.It is not really my argument. First I think that these issues are power user issues.
Yes, but...
And then that there is no clear solution for thisissue, there are many use cases with different choices. So, if there no integrated solution, like something with firstboot, /etc/sysconfig orwhatever the users should not rely on a specific setup and should setup what they prefer and configure it themselves. And they can do that since they are power users. Starting from this point of view it is better to have nothing started nor configured and things only pulled in as dependencies.
...you still need to let them know there is something they need to do, that they never had to do before (which in itself has Irate User potential).
And I strongly disagree with changing from 'something that always worked before' to 'nothing, with potentially catastrophic consequences if you don't know that we removed functionality' being a good idea.
I don't really care that it worked before,
Obviously, I do :-). You're "removing" a feature I depend on. It would be one thing if you have a way to ensure that I know this has been done so that I can re-enable it. You apparently feel differently.
once again it is a very specificuse case and I can't see why it should be priviledged.
...because so far I haven't heard that you've ensured people depending on this will know they have to do something special, now. And, as I've pointed out, that lack of knowledge can have severe consequences.
Because - ok, I told myself I wouldn't, but I'm going to pull out the Big Gun now - if Red Hat did this, and I lost data because of it, I'd be filing a lawsuit. Seriously. You're talking about playing games with people's data, and I don't take that lightly.
And I don't understand why we're still having this conversation. Several suggestions (that, to me at least, seem perfectly reasonable) have already been suggested. Something in anaconda or firstboot would be best (ideally, you could configure things like if you want logwatch at all), that would make sure you either get a local mail MTA, or are required to click through the Big Scary Warning about the Dire Consequences if you elect not to run one. Or make cron require an MTA. Or possibly both.
I'm willing to blame it on user negligence if they knowingly choose not to have an MTA, or purposefully circumvent cron's normal use thereof. I *don't* consider it acceptable for the default cron setup to be changed from one that (IMO) is effective, to one that silently discards output in a way that the user may not even be aware that there is a problem.
Why is that so hard to understand?(And I'll repeat what I said elsewhere. The replies I'm getting from some people seem to indicate that this is a real issue. If I'm really just inventing a scenario that can't happen, /someone bloody please just tell me!/)
I think that it was always a mistake to start sendmail in the default case, and even to install it (not as a dependency).
(I happen to disagree, but that's me... Unless you're only talking about the daemon(smtp) part, and not the MTA part that handles local mail.)
Well it should not be changed within a release, nor by updates, but I would find it normal to have it broken by clean installs (with release notes, if possible).
Who reads release notes? :-) -- Matthew Please do not quote my e-mail address unobfuscated in message bodies. --"You know what Microsoft's problem really is? They've lost the ability to feel ashamed." -- Pamela Jones (Groklaw)


text:
Capital Safety
New Delta Vest Hi-vis Harnesses from Capital Safety address two major safety concerns: fall protection and worker visibility. Available in breathable, reflective orange or yellow fabric, or in blue cotton for added warmth, the vests are modeled on the manufacturer's dependable Delta II harness. They come in four sizes with five points of adjustability, including torso adjusters not found on other brands, to provide a comfortable fit, according to the maker. Price: $135 to $195. 800-328-6146.


text:
Alternative Title: "Voyna i mir"
War and Peace, epic historical novel by Leo Tolstoy, originally published as Voyna i mir in 1865–69. This panoramic study of early 19th-century Russian society, noted for its mastery of realistic detail and variety of psychological analysis, is generally regarded as one of the world's greatest novels.
War and Peace is primarily concerned with the histories of five aristocratic families—particularly the Bezukhovs, the Bolkonskys, and the Rostovs—the members of which are portrayed against a vivid background of Russian social life during the war against Napoleon (1805–14). The theme of war, however, is subordinate to the story of family life, which involves Tolstoy's ... (100 of 236 words)


text: Carefully Peel a 9V Battery to Find Smaller Batteries InsideEric Ravenscraft3/18/16 4:31amFiled to: clever usesbatterieshackingelectronicsdiy676EditPromoteShare to KinjaToggle Conversation toolsGo to permalink If you've ever gotten into electronics hacking, you've probably had the illusion of most gadgets ruined for you. For example, 9V batteries are basically just six AAAA batteries taped together. Advertisement As reddit user usgiorgi points out, many larger store bought batteries contain a collection of smaller batteries. For manufacturing reasons this makes sense. It's also handy if you're building a project and need to tweak your power source.The rest of the components are also handy. Reddit user CaptainKozmoBagel points out that you can salvage the top of a dead 9V battery to make a new 9V connecter with just a bit of wire. Keep in mind, that you shouldn't tear into just any old battery. Lithium ion batteries (like the kind in your phone) can explode if you try to open them up. 9V batteries, though, are pretty safe to tear down. Advertisement if you need a new 9v connector, just solder an old 9v's top up to the leads. | RedditEric firstname.lastname@example.com@lordravenscraftSenior Writer for Lifehacker.Reply67 repliesLeave a reply


text:
Okay, been awhile since I had the chance to write something, because of college and stuff. Sure, I write almost every day and all. It's just that it's all writing for a boring class I'd rather not take if I didn't need it to meet general education requirements. Anyway, I don't really know what else to say here, and I don't have anything to rant about for a change. (Crazy, I know!)
I have to say though, I really enjoyed writing this. It was super fun.
So let's just get to it then.
DISCLAIMER: This is a disclaimer. Pretend I bothered to look like I care about saying DF doesn't belong to me.
OUTSKIRTS OF FORT PASTOR – 9:30 PM (Going by Sherwin's last announcement)
Two men stood nearby the only open entrance into the (relative) safety of the outpost. One of them was carrying an unidentifiable assault rifle (Seriously, the thing had the crap modded out of it. I don't even know if you could call it an assault rifle anymore. I mean, last time I checked, assault rifles didn't barf heat-seeking mini rockets. Of course, this particular weapon didn't shoot rockets at all, let alone heat-seeking ones, so I have no idea what the hell I'm talking about. By modded I meant that it was just pink. Hot pink. Tacky hot pink. Why the hell would anyone want a hot pink assault rifle? Not a clue, just roll with it.), while the other seemed to be carrying nothing but a wooden baseball bat. The man with the baseball bat had it slung over his shoulder, while wearing a pair of smudged shades, leaning against a fence, trying to look all cool and bad-ass.
Although he was already a bad-ass. It's just that nobody notices your bad-assery unless you're also cool. Which is something he happened to lack. And no amount of cool-kid leaning on inanimate objects was going to help him any. In fact, in the long run, it would probably just lead to back problems.
But he doesn't need to know that.
Anyway, these two fine fellows were standing guard, doing things guard standing guard do. Like lean on things, call each other names, and pick their noses. Not as in picking each other's noses, because that would just be creepy.
For now on, up until they get a proper introduction with names, we'll just call them Pinky and Cool Kid.
It was a pretty calm night. There hadn't been any major zombie-related issues. Sure there was that one infected that somehow found a skateboard, learned how to ride it somewhat, and then charged at Pinky at full speed while riding it, but that was more of an annoyance, since it hit a loose rock and flung itself head-first into the side of a building and died from brain injury. Not all infected are created equally, and I guess some of them just have skulls that rival a wad of soggy toilet paper.
Then Pinky picked up the sound of shuffling footsteps coming from the muggy darkness that surrounded the outpost (And pretty much every single other place in the world that didn't have some sort of lighting at 9:30 in the night).
"Heey, you hear that?" Pinky said, daring not to look over at his current partner.
"Yeah," said Cool Kid, "Doesn't sound like one of them damn mutants though. Sounds like boots or something."
"But this late at night I doubt there would still be someone dumb enough to stay that far outside. Unless…OH MY GOD! WHAT IF THEY LEARNED HOW TO WEAR SHOES? WE'RE DOOMED! DOOMED I TELL YA!"
Cool Kid slapped his partner across the face. "Get it together man. Bad shit always happens if you don't keep your cool!"
Pinky calmed down just enough to see the outline of a human-shaped figure in the inky darkness.
"Oh Christ! It's here, right in front of us!" Pinky readied his gun, ready to shoot the entity full of metallic death.
"Cool it! Hold up a bit," Cool Kid demanded. He then turned towards the advancing figure. "If you understand, stop right where you are. Come any closer and this guy will reform your body into swiss cheese. "
"God damnit! I finally forgot about that stuff, and you bring it up again! DON'T TALK ABOUT FOOD I'LL NEVER GET TO EAT AGAIN!"
"Uh, whoops. Sorry 'bout that."
The human-shaped figure stopped without a sound.
"Oh. So you do understand, huh? Well I have to make sure you're not some super intelligent deathbringing zombie dude and all, so bear with me here." Cool Kid paused for a moment to think of a suitable task. "Wave for me."
The human-shape waved one of its appendages. More than likely its arm. Well hopefully its arm.
"Right. Uh, roll over."
"Dude, this thing isn't some pet dog or something," mentioned Pinky.
"Oh, right. Uh. I knew that. Erm, do an interpretive dance for me. I think that should verify things."
"What if it's a ballerina zombie or something?"
"Wait, they have those?"
"Hell if I know."
The human-shaped figure just shrugged.
"No idea how to dance? Me either. At least we ruled out you being a ballerina zombie."
"Just say something," declared Pinky.
"Damn. Why didn't I think of that?"
"Can I come in now?" said the mysterious entity.
"There, problem solved." Said Pinky.
Cool Kid turned to look at his partner. "Wait. How do you go from flip-out mode to calm, collected, intelligent mode so fast like that?"
"Oh," Pinky blinked. "I guess you're right. I didn't even notice."
"No really," said the mysterious entity. "Standing in the dark is starting to get annoying."
"Oh! Oh, right!" exclaimed Pinky, who had completely forgotten about the mysterious entity standing in the darkness. "Come on, come on."
Out of the darkness walked a priest, carrying nothing but the battle axe strapped to his back.
"Oh shit," said Cool Kid, "We left a priest waiting in the dark like that. We're so totally going to hell."


text:
Apple brings new tools to musicians with launch of Music Memos, Garage Band update
CES this year was all about accessories, and out on the show floor we saw no shortage of headphones, keyboards, and tools ready to turn your mobile device into a music-creation powerhouse. You don't always need fancy hardware to cook up some compelling tracks, though, and today Apple brings its users both one new and one updated tool to keep them cranking out some of their own hot tunes.
The new player is an app called Music Memos, and it gives musicians the ability to quickly and easily capture some off-the-cuff jams in a high-quality lossless format. Beyond simple recording abilities, the app lets users detect rhythm (and add in drum and bass tracks), giving song-writers a shortcut for getting tunes out of their head and into a much more accessible format. Music Memos supports a robust note-taking and tag system, letting users document their latest recording for future recall.
Next up we have an update for GarageBand, and the big deal here is a new loop tool. You can sample recordings and quickly set up some repeating beats, remixing them as you go along.
There's also a new "Drummer" feature that offers recording of virtual performers, each with their own distinct sound, as well as newly implemented automation tools. For 6S devices there's also 3D Touch support.
Music Memos is free for users to download, while GarageBand pricing remains unchanged.
Source: Apple


text:
He's a fine marmalade tabby with matching orange eyes. Soon my nearly-unpacked house will be a marmalade tabby house, because it's the time of year for Theo to blow his winter coat for his summer one. The set of cat infrastructure includes three brushes and a comb — this for a shorthair. So many things I'd forgotten about living with cats. I'll have to start putting Static Guard spray on my grocery list again.
I remember last time I did Nanowrimo, when I still had two cats, I included their meddling in my word-count metrics: 1200 words, 2 hours, persistent cat on keyboard. Surely my creative productivity will increase, now that I have a cat to sit on my important books and papers.


text: American Civil Liberties Union Indiana Can't Ban Syrian Refugees By Michael Puente • Oct 3, 2016 The U.S. Court of Appeals upheld a lower court ruling today that prevents Indiana from banning refugees from Syria. Days after terrorists struck Paris last November, Indiana Governor Mike Pence placed a ban on Syrian refugees from being resettled in the state. Court to weigh appeal on Indiana's block on Syrian refugees By Michael Puente • Sep 14, 2016 Flickr Creative Commons/Mark Taylor A federal appeals court in Chicago is deciding whether the State of Indiana has the right to ban refugees from Syria. Days after terrorists struck Paris, France last November, Indiana Governor Mike Pence placed a ban on Syrian refugees from being resettled in the state. Walgreens Clinics Run by SSM to Include Birth Control By Associated Press • Aug 25, 2016 The nonprofit Catholic organization SSM Health says it will provide birth control pills at 26 clinics inside St. Louis-area Walgreens stores that it began operating today. Four groups, led by the American Civil Liberties Union, wrote letters to SSM and Walgreens on Aug. 18, asking whether the clinics would be restricted by religious doctrine from allowing consultations on birth control. Groups Press Walgreens on Religious Restrictions in Clinics By Associated Press • Aug 18, 2016 Four groups led by the American Civil Liberties Union are asking Walgreens for reassurance that the drugstore's partnership with a Catholic system to run in-store clinics in the St. Louis area won't limit access to birth control. DCFS claims federal court-appointed monitor unnecessary By Patrick Smith • Aug 18, 2015 The Illinois Department of Children and Family Services is trying to avoid oversight by a court-appointed monitor. Attorneys representing DCFS and the American Civil Liberties Union were in federal court today for the first time since a mandated assessment recommended independent oversight. DCFS prepares for budget cuts By Tony Arnold • Jul 14, 2015 Illinois' Department of Children and Family Services is telling contractors to be ready to make cuts if political leaders ever agree on a spending plan. A federal judge told DCFS to provide the same level of services as it had in June, until the governor and legislators approve a budget. But DCFS is pre-emptively telling its contractors to also get ready for 10 percent cuts - though there is no budget guiding that. Ben Wolf is with the American Civil Liberties Union - and has sued DCFS over its quality of care before. Lawsuit filed against Chicago police over stop and frisk By Associated Press • Apr 22, 2015 A federal lawsuit filed against the Chicago Police Department contends officers have routinely violated the constitutional rights of minority residents who have not committed any crime. ACLU suing the City of Peoria By Alex Rusciano & Tanya Koonce & Daniela Vidal & Tamie Yost • Jun 12, 2014 Tanya Koonce / Peoria Public Radio The American Civil Liberties Union is suing the City of Peoria for police actions surrounding a controversial Twitter parody account. Peoria Public Radio's Tanya Koonce reports: Listen Listening... / 1:14 The suit says the City violated 29 year-old Jon Daniel's First and Fourth Amendment rights. Daniel is the creator of the At-Peoria-Mayor account. He says its wrong that police searched his home in April, detained him and his roommates and seized all electronics to find the author of the Twitter account that had already been suspended."My hope it he federal court will make clear that government officials can not use the power of police to threaten, intimidate and punish simply because they dislike or are offended by being the joke of a parody." Daniel says he's never met the mayor and is not politically active.


text:
A circulatory/Vascular tonic, memory enhancement, nerve funtion, anti-depressant, anti-allergic, antioxidant and immuno-modulatory properties.
Cheapest price we found
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Prices are updated periodically, the prices quoted here were correct at the time of last update.
Patient gathers information on a vast range of over-the-counter treatments and beauty products from reputable websites and registered online pharmacies. We perform a price comparison so that you can see who offers the best price.


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Rates in SGD (taxes & fees included), shown as:
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Magic Andorra 4
PASSATGE ANTONIA FONT CAMINAL 1 DESPATX 502, Other, Andorra la Vella AD500, Andorra
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Check-in: 14:00
Check-out: 12:00
20 studios and apartments with kitchenette (with kitchenware), satellite TV, heating, bed linen and towels. Bathrooms equipped with bathtub or shower and hairdryer. Some apartments feature a terrace overlooking the Valley of Anclés. The establishment also features indoor parking (with surcharge) and free mini-bus service to the ski slopes.
PASSATGE ANTONIA FONT CAMINAL 1 DESPATX 502 Other, Andorra la Vella AD500, Andorra


text:
Ship, by Thalia Valencia
As we drift gently along the stream of time
Beyond the storm
Among the waves
Of dust left on a shelf
We are but stowaways
On the ship that sails itself
© Copyright 2017 whysosirius394. All rights reserved.
Status: Finished
Genre: Poetry
Short Story / Young Adult
Short Story / Religion and Spirituality
Poem / Poetry
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Jonathan Brown of Illinois provides us with this weekend's dirtiest football hit, delivering a knee to the groin of Patrick Ward from Northwestern, only to get caught by the official nearby. More →
What can we say about this photo of Elizabeth Turner and not ruin the moment? Sleek boat, red bikini, perfect underboob, beautiful woman, the sea looks great. That's about it. More →


text:
Evi is our best selling mobile app that can answer questions about books, music, films, conversions, history, people, places and much more.
To experience the full power of Evi you can download her app for free on iOS, Android and Kindle Fire.
ethanol, the alcohol found in alcoholic beverages, also known as ethyl alcohol or grain alcohol
chemical (material produced by or used in a reaction involving changes in atoms or molecules)


text:
Upcoming Classes & Workshops:
For information on City-sponsored graywater and rainwater harvesting hands-on workshops, 101 classes, and installation options, please contact the Sweetwater Collaborative.
- A "Laundry to Landscape Graywater Systems" DVD is available for loan through Santa Barbara Public Library System.
Rebates on laundry to landscape graywater systems may be available as part of the Smart Landscape Rebate.
Rebates on replacing high water using landscapes with rain gardens may be available as part of the Smart Landscape Rebate.


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8 Great Charcuterie Spots in Boston
Feeling board? If a sophisticated spread of meats, cheeses, marinated veggies and various accoutrements is on your agenda for the evening, here's where to go for some of the best charcuterie menus around Boston.
Belly Wine Bar: We could stuff ourselves silly with Belly's "arm + a leg" family-style meals, a rotating whole-animal feast (currently duck) that requires a few days' notice. But for a lighter something to share over wine, the charcuterie boasts luscious chicken liver mousse, crispy duck en croute with pistachios and prunes, and a fantastic fromage selection curated by its sister establishment, the wine and cheese shop Central Bottle (617-494-0968).
The Butcher Shop: As one would expect from its name and pedigree (it's part of the Barbara Lynch empire, after all), this spot brings out a fabulous charcuterie selection, from soppressata to finochiona (fennel salami), game bird en croute and rillettes du jour. That you can bring home its cured meats, housemade sausages and pâtés from a glass case kept stocked by its full-time butcher and assemble your own charcuterie on the couch is a Butcher Shop bonus (617-423-4800).
Coppa: Since chef Jamie Bissonnette was early on the forefront of nose-to-tail dining in Boston, it's not surprising that his South End corner Italian, Coppa, would have one of the city's best salumi boards (pictured), starring beef heart pastrami, duck prosciutto and excellent offal. The meats share menu space with American and Italian cheeses selected by the restaurant's neighbor, boutique fromagerie Formaggio (617-391-0902).
Eastern Standard: This Kenmore Square gem deserves the praise it receives for its daily charcuterie, a never-less-than-stellar assemblage, as well as its celebrated cheese selection. A three- and five-cheese spread with toast and accompaniments is a must-try for ES newbies (617-532-9100).
The Gallows: On the South End, this boisterous hangout always attracts a motley crew, from foodie hipsters to neighborhood yuppies. Among its elevated tavern-style offerings are the top-notch boards it composes. The Ploughman - currently boasting housemade rabbit sausage, Serrano ham, chicken liver pâté and whipped lardo with pickles and various artisanal cheeses - is always a favorite. There's also the Farmer, a fruit-, cheese- and nut-filled take on a charcuterie board for veggies (617-425-0200).
Oak Long Bar + Kitchen: How hungry are you? This fabulous Fairmont Copley restaurant offers three different sizes of its charcuterie board, each loaded up with cured meats, local cheeses, marinated olives and various preserves: the Oak ($24), Kitchen ($31) and LBK ($55). Pick your platter, and let Oak pick what's on it (617-585-7222).
The Salty Pig: Straddling the South End and Back Bay, this joint is without a doubt one of the best places in the city to oink out on a charcuterie board, assembled with selections from three awesomely named menu categories: Salty Pig Parts (including wild boar cacciatorini and smoked beef tongue), Stinky Cheeses (from neighboring Vermont and European destinations alike) and Round Out the Plate (including accompaniments like jalapeño jelly and smoked shallot marmalade) (617-536-6200).
51 Lincoln: Head to the suburb of Newton for some of the area's top charcuterie, which ranges from chile chicken liver pâté to beef pepperoni and fromage including a fab brie fermier from Wasik's Cheese Shop (617-965-3100).


text:
Diver uses platform after winning gold to share his passion
Victory at the London Olympics has elevated David Boudia to a new level of fame — and a new set of opportunities.
Victory at the London Olympics has elevated David Boudia to a new level of fame — and a new set of opportunities.
The four South Korean badminton players who purposely tried to lose at the London Olympics had their bans reduced to six months.
Australian parliament praised the "heroism and humility" of Peter Norman for standing in solidarity on the black power podium.
Lolo Jones gets what she needs back home in Des Moines. "After the Olympics, I was feeling my heart get quite cold and bitter," she says.
UConn coach Geno Auriemma said he has no interest in returning as head coach of the U.S. women's basketball team for the 2016 Rio Games.
Morgan Uceny, who was tripped in the Olympic 1,500-meter final, has pulled out of a Friday race because of injuries resulting from her fall.
Even before the closing ceremony, athletes from Cameroon, Eritrea, Guinea and the Ivory Coast had disappeared from the athletes' village.
A court has delayed sentencing a British man who admitted spying on members of the Chinese Olympic swimming team in a women's changing room.
The final of event of the PGA Tour's regular season, the Wyndham Championship, will close out the chase to make the playoffs.
Gabby Douglas admitted indulging in post-Olympics fast food to healthy eating advocate Michelle Obama, who teased the gymnastics champion.
Many residents of this cynical and curmudgeonly town didn't want the Olympics to start. Now no one wants the Games to end.
In the end, it's all about the athletes. So let them have the final words - poignant, joyous or bizarre.
The 16-year-old gymnast said she marked her stellar Olympic showing splurging on a McDonalds' sandwich.
A judo player and three other members of the Democratic Republic of Congo's Olympic delegation have been missing since the weekend.
Bruce Jenner, who won the gold medal for the decathlon in the 1976 Montreal Games, has a different definition of "athlete" than Bolt.
With Coach Mike Krzyzewski announcing his departure from Team USA, where he went 62-1, we ponder the next chapter for U.S. basketball.
Shot putter Nadzeya Ostapchuk of Belarus became the first athlete to be stripped of a medal at the London Olympics.
The 17 days of the London Games made the world seem a little smaller. Here are 10 athletes from 10 countries who inspired us.
Anthony Joshua beat Italy's Roberto Cammarelle in front of a hometown crowd, grabbing Britain's third boxing gold medal at the London Games.


text:
Academic Research in Computer Security or Network Security
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- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Temporal lobe epilepsy (TLE) is a prevalent, often drug-resistant form of epilepsy usually preceded by injury which progressively leads to the development of recurrent unprovoked seizures by a process known as epileptogenesis. The role of mitochondria in TLE is recently emerging;however whether and how mitochondrial functions contribute to TLE remains unknown. It is hypothesized that mitochondrial oxidative stress plays a key role in epileptogenesis. We seek to determine whether and how mitochondrial reactive oxygen species (ROS) contribute to epileptogenesis. Preliminary data suggests that mitochondrial oxidative stress occurs to varying extent throughout epileptogenesis in two chemoconvulsant models of epilepsy. Using a diversity of approaches including state-of-the-art mitochondrial redox techniques, mass spectrometry and continuous video-EEG monitoring in two chemoconvulsant animal models, the following specific aims will be examined.
Specific Aim 1 will determine the occurrence of mitochondrial oxidative stress during epileptogenesis and establish a cause-effect relationship between oxidative stress and epilepsy development.
Specific Aim 2 will determine how mitochondrial ROS contributes to epileptogenesis. Specifically the role of posttranslational oxidative modification of complex I and mitochondrial DNA damage and repair will be examined.
Specific Aim 3 will determine if pharmacological inhibition of mitochondrial oxidative stress can prevent epileptogenesis. These studies will establish a potential role of mitochondrial oxidative stress in epileptogenesis and suggest novel therapeutic approaches for modifying the progression of TLE.
Temporal lobe epilepsy (TLE) is a prevalent form of acquired epilepsy often resistant to drugs and progressive in nature. Metabolic changes including mitochondrial dysfunction occur in TLE but how they contribute to its progression remains unknown. The goal of this project is to determine if a key function of mitochondria (reactive oxygen species) contributes to the development of epilepsy in animal models of TLE. Furthermore, the project will test the efficacy of drugs that are known to prevent mitochondrial dysfunction in TLE animal models.
|Ryan, Kristen; Liang, Li-Ping; Rivard, Christopher et al. (2014) Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy. Neurobiol Dis 64:8-15
|Pearson, Jennifer N; Schulz, Kalynn M; Patel, Manisha (2014) Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus. Epilepsy Res 108:1032-40
|Gano, Lindsey B; Patel, Manisha; Rho, Jong M (2014) Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res 55:2211-28
|Brooks-Kayal, Amy R; Bath, Kevin G; Berg, Anne T et al. (2013) Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia 54 Suppl 4:44-60
|Rowley, Shane; Patel, Manisha (2013) Mitochondrial involvement and oxidative stress in temporal lobe epilepsy. Free Radic Biol Med 62:121-31
|Liang, Li-Ping; Waldbaum, Simon; Rowley, Shane et al. (2012) Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: attenuation by a lipophilic metalloporphyrin. Neurobiol Dis 45:1068-76
|Durazo, Shelley A; Kadam, Rajendra S; Drechsel, Derek et al. (2011) Brain mitochondrial drug delivery: influence of drug physicochemical properties. Pharm Res 28:2833-47
|Cantu, David; Fulton, Ruth E; Drechsel, Derek A et al. (2011) Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H?O?. J Neurochem 118:79-92
|Drechsel, Derek A; Patel, Manisha (2010) Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system. J Biol Chem 285:27850-8
|Waldbaum, Simon; Liang, Li-Ping; Patel, Manisha (2010) Persistent impairment of mitochondrial and tissue redox status during lithium-pilocarpine-induced epileptogenesis. J Neurochem 115:1172-82
Showing the most recent 10 out of 29 publications


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It's not just about keeping records. Ensuring safety is critical; it's not just about keeping records and implementing programs. Cannon has a "Zero Target" safety program which is …
We are doing our part. From our projects to our work space, we are working to reduce the environmental footprint. As an advocate of sustainable practices, we continuously look for ways …
We're Not Just Another Consulting Firm
Access to clean water is something we take for granted.
For some it's an every-day struggle. Join us in raising 100K in 2016.
Well Worth It Pancake Breakfast
Give your beloved a sweet treat this Valentines& help others too!


text:
Kids English: Recognize food
by: KIDS PUZZLE • 21
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by: KIDS PUZZLE • 21
This is a kids learn English theme puzzle game, let the kids play this game, easy to learn these English words.
How to use:
Gently slide your finger to click on the correct answer, go to the next level game completed!
Tags: bambini imparano italiano , english test for kids food online , anglais gratuit enfant , english test about food for kids , app età prescolare italiano , 兒童學英語特點 , 兒童學英語
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UPCOMING EVENTSUpcoming Events
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Archaeologists say writings on an ancient tablet confirm there was a global flood and an ark that carried animals. In 2014, a 4,000-year-old clay tablet was discovered in modern-day Iraq -- which is ancient Mesopotamia. When it was deciphered it revealed striking similarities to the biblical account of Noah. The tablet describes a massive flood that destroys the earth and instructions that animals should be loaded onto the craft "two by two." Read More...


text:
When your car goes into the shop with rental reimbursement coverage, you will arrive at your neighborhood Enterprise location, the office will already have the information to direct bill your insurance carrier for the covered amount of your rental.
When you arrive at your local Enterprise you will need:
We recommended that you contact the local Enterprise before arrival to ensure you have all necessary information prepared. This will allow your rental process to be quick and easy.
A glimpse into life without Rental Replacement Coverage
Our professional sales consultants will listen and work with you to understand both your needs and your budget. With thousands of late-model, low mileage options, we will find the right vehicle to get you back on the road worry-free.
Think a rental car can't be as good as your own car? Enterprise has one of the largest selections of premium vehicles.
Something bad happens to your vehicle.
Your vehicle goes in the shop to be worked on. It's likely to take 13 days.
Enterprise, in partnership with your insurance company, will take care of you while your vehicle is away.
After your vehicle is ready, you both get back on the road and back to normal – all without missing a beat.
people get into a car accident each year.
vehicle repair lasts about
of rental reimbursement cost
of a rental's cost.
*If you don't currently have rental reimbursement insurance but still need to rent a vehicle, you still can at our every day low rates. Be sure to check our FAQ if you have questions.


text:
Need doc to expand on bug 158384
I'am glad you finally made it work
we are about to form a community that use mozilla autoconfig, and hopefully
we'll be enough to assure that developpers keeps make this unvaluaible feature
work, and maybe more documented ....
there are several bug reports opened related to autoconfig, feel free to
contribute and/or vote !
aschroe1 wrote:
> jehan.procaccia schrieb:
>> getenv OK , just check in shell that the value of USER is what is expected :
echo $USER
>> your locPref above is wrong , don't add the "+" sign ! you (an I !) use +
sign in the the javascript file to concatenate strings, here you just have to
call the string:
>> lockPref("mail.identity.id1.useremail", env_user );
> Hello,
> I've got the solution; I dont't believe really
> -the first line of my js/cfg script has to begin with //
> -your tip leaving out the "+" sign in fornt of the variable
> (I tried this before, but without the first comment line)
> that's it! zzzz..zzzz..zzzzz
> Thank you very much for your support,
> merci bien (just another two of my few french words) :- ))
> -------------------------------------------------------------
> Alfred Schroeder - Lernstatt Paderborn -
> firstname.lastname@example.com
> -------------------------------------------------------------
references (from bug 241534)
Created attachment 152002 [details]
Configuration Configuration and Auto-Admin reference
WIP from bug 178685
Thanks for you documentation (attachement) and the wonderfull pages you opened on
http://wangrepublic.org/daniel/mozilla/prefs/ thanks to bugid=178685 :-).
However (I haven't read everything yet ...) I noticed on mozilla 1.7 on windows
palteform at least, that there's no more all.js file. To bad .. it's where I set
my general.config.filename directive for mozilla auto-config, cf:
should I set it somewhere else or create an empty all.js file containing only
that directive ?
Now I see that all.js file is opened on a different folder since 1.7.2 on linux.
it used to be in MOZILLA_HOME(here /usr/lib/mozilla-1.7.3/)/default/pref, now
it's in MOZILLA_HOME/grepref/ .
The problem is that this directory is by default only readable by root (700), so
users on my stations that use mozilla autoconfig (general.config.filename
directive in all.js) don't get the autoconfiguration set anymore :-( .
A workaround is to set grepref directory to 755, but is this safe ?
Second question, where should I but general.config.filename directive in the
future (default/pref/all.s or grepref/all.js ?)
PS: I will update my mozilla autoconfig doc in consequence ...
Gregg Berkholtz wrote:
> In bug 222973, you mentioned that setting up a community to help track and/or
manage Mozilla/Firefox/Thunderbird enterprise needs. Did you ever do this? If
so, how do we join?
Jehan Procaccia writes :
no, I've just hoppened several bug on bugzilla, but that's all .
Actually I don't know how many people use autoconfig, but this tool is very
usefull ! and I hope it will still work with firefox/thunderbird (I haven't
tested yet, but in next september our 2000 students will use Fedora Core 3 or 4
which comes with these tools now ...)
Do you have an idea on how to create or maybe join an already existing
autoconfig user's community ?
I've created a guide describing how to setup Autoconfig with Mozilla Firefox.
Take a look:
I also have a brief writeup describing how autoconfig is setup at MIT, and a
link to the relevant files:
(In reply to comment #7)
> I've created a guide describing how to setup Autoconfig with Mozilla Firefox.
> Take a look:
> http://mit.edu/~firefox/www/maintainers/autoconfig.html
> I also have a brief writeup describing how autoconfig is setup at MIT, and a
> link to the relevant files:
> http://mit.edu/~firefox/www/maintainers/config.html
Charles has done an excellent job here of documenting the baroque Mozilla
configuration process. But it would be much better if the software was changed
so that much of the complexity vanished. For example:
(1) The configuration file should not have to reside in the software directory,
because that way it is highly likely to get lost or overwritten whenever the
software is upgraded. Instead the software should follow Unix FHS standards and
look in /etc/opt/mozilla/ (perhaps followed by some other places).
(2) There should be a sensible default name, e.g. siteprefs.cfg. At the moment
the administrator has to use the old complicated user preference scheme just to
enable the new simpler one.
(3) What on earth is the ROT13 business for? The default should be to accept a
plain text file (and maybe accept ROT13 for backward compatibility).
My comments are Unix-orientated; I guess Windows doesn't have an equivalent of
the /etc directory. But if these changes were made then most of section 2 could
be eliminated and replaced by something like
You need to put your site preferences in a file called siteprefs.cfg. On Unix
this file should be put in the directory /etc/opt/mozilla; on Windows put it in
the base of the Mozilla installation directory.
FYI, I've just updated the doc on autoconfig/MCD feature on mozilla products with TB 2 beta 2 and firefox 2.x
Moving to Mozilla Developer Center product.
Automatically closing all bugs that have not been updated in a while. Please reopen if this is still important to you and has not yet been corrected.
Reopening for review by Sheppy.
I'm closing this; the build/setup docs are pretty decent, plus the build system is going through changes that will make this moot even if it's not covered anyway.


text:
#include <Keypad.h>const byte ROWS = 4; //four rowsconst byte COLS = 4; //four columnschar keys[ROWS][COLS] = { {'1','2','3','A'}, {'4','5','6','B'}, {'7','8','9','C'}, {'#','0','*','D'}};byte rowPins[ROWS] = {2,3,4,5}; //connect to the row pinouts of the keypadbyte colPins[COLS] = {6,7,8,9}; //connect to the column pinouts of the keypadKeypad keypad = Keypad( makeKeymap(keys), rowPins, colPins, ROWS, COLS );
whichkey = keypad.getKey();
I get this error compiling with a CMake make file
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"Your wisdom and strength to lead us towards greater unity and that we may have peace and order, safety and justice for all."
"God expects every Christian to strive for holiness. Holiness is not just for certain ones in the church but for all of us."
Everyday we should be concerned about sin. In every thought, word and action we take we must remember that we are a holy nation unto God.
Someone has said that life is like a cafeteria: You get to choose what you want, but at the end of the line you will have to pay for it


text:
About Me
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Tuesday, July 8, 2008
The Big Seagull Post
Seagulls are some of the coolest birds... if you can keep them from pooping on your head, of course! Mr. Wing-It likes feeding them and I like photographing them, so that works out perfectly. These are a few of the seagull pictures that I have taken through the years.
Mackinaw City/St. Ignace, Michigan:
This picture needs a background sound effect: screeching tires
No problem, ociffer. I am not drunk, I can line a straight walk...
One is the loneliest number...
Sunrise on Lake Huron
Duluth, Minnesota:
It's a Seagullsaurus!
Salt Lake City, Utah:
Environmentally conscious seagull picks up the trash
Houston, Texas:
Hey, 'sup?
Somewhere in Washington:
Yes, we did. Please don't alert the FBI! :)
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