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Asbestos – The Primary Cause of Mesothelioma
Asbestos, the only known cause of mesothelioma, is a fibrous mineral found in rocks and soil. Prior to 1980, it was commonly used in building and construction materials in buildings, homes, and schools.
What Is Asbestos?
Key Facts About Asbestos
Widely Used Building Material
Asbestos was a critical building component in the military, used in virtually every naval ship from the 1930's to 1980's. It was also used in most construction trades during this period.
Used for Thousands of Years
Asbestos has been used since before 3,000 B.C. Records show ancient Egyptians pointing to a related illness that afflicted those who worked with the mineral.
Naturally Occurring
Asbestos is a naturally occurring mineral that was often used in manufacturing for its fire-resistant and insulating qualities. It is still widely used in some countries across the globe.
Types of Asbestos
Some parts of the world still use asbestos because it is cheap and convenient in manufacturing. Asbestos can still be found today and there have been several other minerals which also pose a threat to those who breathe in the fibers.
Serpentine vs. Amphibole Asbestos
There are two different kinds of asbestos fibers. Serpentine fibers are curly and less harmful to the human body, because they are easier to flush out. Amphibole fibers are straight, rigid and sharp. This causes them to lodge into organs and tissues more easily than serpentine fibers. Amphibole fibers are more likely to cause mesothelioma and lung cancer than serpentine fibers.
Asbestos Subtypes
There are six different subtypes of asbestos used in products: tremolite, actinolite, anthophyllite, chrysotile, amosite, and crocidolite. The three most common used asbestos types are chrysotile, amosite, and crocidolite. These three are commonly found in construction materials and automobile parts, like brake pads.
Chrysotile asbestos is also known as "white asbestos" and is the most commonly used form of asbestos. It is primarily found in car gaskets, brake pads, brake linings, insulation, and cement. It is far less likely to become lodged in the lungs compared to the other forms of asbestos because of the serpentine nature of the fibers. Even though it is considered the "safest" form of asbestos, it can still cause illnesses like mesothelioma.
Amosite asbestos is also known as "brown asbestos" or grunerite in its natural form. It is one of the more dangerous forms of asbestos to come in contact with. Amosite has been used to make ceiling tiles, insulation, fire protection, and cement sheets. These fibers are extremely friable, meaning they crumble easily. This results in airborne particles that can be inhaled. Amosite asbestos is made up of amphibole fibers which have a higher risk of causing cancers.
Crocidolite asbestos is also known as "blue asbestos" and is the least commonly used in materials. Crocidolite is the most hazardous of the asbestos family, as it contains amphibole fibers and causes mesothelioma.
It is most commonly found in cement products. Crocidolite asbestos was mined in South Africa and Australia, but it is no longer mined because of the health hazards. Learn more about how asbestos causes mesothelioma in our free Mesothelioma Guide.
History of Asbestos
It is impossible to pinpoint the first uses of asbestos, but archeologists have found traces of the mineral in Scandinavian excavations (pointing to 3000 B.C.). Greek and Romans used the material as fire retardant cloth and building materials.
There are traces of asbestos in suits of armor in the medieval times and for embalming pharaohs in ancient Egypt. The hazards of asbestos were noted in civilized Roman times. Pliny the Elder noted many slaves who worked with asbestos were dying young. Many have speculated that this was mesothelioma or similar complications.
As the Industrial Revolution engulfed America in the early 1800′s, manufacturers found asbestos helped to insulate pipes and fireboxes. Soon, asbestos was mined and used in every facet of construction and manufacturing. It was also used in shipyards, railroad cars, and automotive factories. As time went on, the demand for asbestos increased.
In 1898, inspectors in Great Britain called asbestos one of the top four deadliest dusts in the world. In the early 1900's, however, the amount invested in insurance policies began decreasing for those with occupational exposure to asbestos.
Even though many companies were aware of these risks, they continued to allow their employees to be exposed.
Although health risks were known, asbestos materials were being used in building houses, schools, and office buildings up until the 1980's.
Where Is Asbestos Found?
Asbestos is extremely flame-resilient and does not corrode. As a result, it was used in many buildings, homes, and schools built prior to the 1990's. It has been used in many building materials, such as:
- Tiles
- Insulation
- Roofing shingles
- Paper products
- Automobile parts
There are also many asbestos mines throughout the United States. Those who have worked directly with asbestos materials have the highest risk of developing asbestos related cancers. However, secondary exposure can also occur from the people they live around. Many mesothelioma patients were exposed from their loved ones.
Similar Toxic Fibers That Cause Mesothelioma
Vermiculite is a naturally occurring metamorphic mineral composed of shiny flakes. It is primarily used for gardening and construction purposes. It is heat resistant and light-weight. It is mined in raw ore deposits. On its own, vermiculite is not hazardous.
Vermiculite is rarely contaminated by asbestos; however, it can happen if the two are mined near each other.
Erionite is a naturally occurring fiber that is found in volcanic ash. It is often compared to asbestos because of its hazardous fibers. Erionite can be found in fibrous form, like asbestos and vermiculite. In the past, erionite was not seen as a health risk.
However, it has proven a hazard to those who come into contact with it. Patients have been diagnosed with mesothelioma as a result of being exposed to erionite. These fibers are only a threat if they become airborne. Studies have shown that erionite can be up to 800 more times as carcinogenic than asbestos.
Erionite is found in gravel, rock, or soil. It is no longer mined for use in commercial items. It has been used in minor amounts in the building of some homes in the Western part of the United States (Arizona, California, Idaho, Nevada, New Mexico, North Dakota, Oregon, South Dakota, Texas, Utah, and Wyoming).
Taconite is a sedimentary rock containing iron. After World War II, taconite was heavily used as a source of metal. It is commonly used in the production and manufacturing of steel beams and sheets. Shipbuilders and construction workers are commonly exposed to taconite products.
Taconite is compared with asbestos because of similarities in chemical makeup and the potential hazards. There have been cases of mesothelioma linked to taconite exposure. It is extremely prevalent in Minnesota, where there has been an increased number in mesothelioma diagnoses.
A large amount of taconite is mined and produced in "Iron Range", Minnesota. This is an area in northern Minnesota famous for its large deposits of iron ore. Taconite products are commonly distributed into the surrounding Great Lakes Region.
Asbestos and Mesothelioma
Asbestos is the only known cause of mesothelioma, which most commonly affects construction and trade workers and veterans. Luckily, as asbestos and mesothelioma are continually researched, treatments for this disease are getting better.
If you have mesothelioma, the most important step to take is finding an experienced specialist to treat your disease. Get connected to a specialist our free Doctor Match program today.


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Circuit nominee picked
LOS ANGELES – Paul J. Watford, a Los Angeles attorney with broad experience and the support of some influential local conservatives, was nominated by President Barack Obama on Monday to the busiest appeals court in the country.
The choice of Watford, 44, for the 9th U.S. Circuit Court of Appeals drew praise from colleagues on both sides of the political aisle and predictions that he will have a smoother path to Senate confirmation than some of the president's more liberal nominees.
The 9th Circuit has long been the most overwhelmed of the 13 federal appellate circuits and has seen its burdens mount this year with the deaths of five judges. If confirmed, Watford will fill the vacancy created on Sept. 21, when Circuit Judge Pamela Ann Rymer died of cancer at age 70.
The court is authorized to have 29 active judgeships but has four vacancies, with a fifth expected at the end of the year. Obama has three pending appointments to the 9th Circuit, with Watford joining Alaska Supreme Court Justice Morgan Christen and U.S. District Judge Jacqueline Nguyen of Los Angeles in what can be a contentious and protracted confirmation process.
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subset: commoncrawl


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Monte Carlo
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Monte Carlo Hotel Details
Check-in: 12:00
Check-out: 10:30
Set in an English style cottage with a cosy fireplace, Las Acacias is a 10-minute drive from Cerro Bayo Hill Ski Centre in Villa la Angostura. Guests can enjoy an outdoor swimming pool in the summer. Wi-Fi is free.Hosteria Las Acacias has rooms with chic décor, cable TV and private bathrooms with bathtubs.Guests staying at Las Acacias can go on day trips to Manzano Bay 200 metres away, the 7 lakes circuit and Arrayanes National Park. Fishing excursions can also be arranged.A daily breakfast with regional jams is served daily.Bariloche Airport is 90 km from the inn and the town's commercial area is a 10-minute drive.


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Opening Hour
00.00 - 00.00
Opening Days
Monday - Sunday
125/14-15 Moo 7, Koh Phi Phi, T.Ao Nang, A.Muang, Krabi 81000 Thailand
+66 2 5806041,+66 81 4349305,+
Undoubtedly the finest steak house on Phi Phi Island, serving from a tremendous selection of international favorites such as Sirloin steak, Greek kebabs, Mexican nachos and our famous Scandinavian Meat Balls. Run by Matts from Denmark, known as the stylish and happy patron, and pleasing repeat customers from all over the world.
Address :
125/14-15 Moo 7, Koh Phi Phi, T.Ao Nang, A.Muang, Krabi 81000 Thailand
There is no review available for this place at the moment. If you've been there and would like to write a review, please visit TripAdvisor.com


text:
Patty's Southern Style White Cornmeal Cornbread
Total Time
Prep 45 mins
Cook 0 mins
This recipe comes from a friend of mine who is a native Mississippian. This recipe comes to her passed down within her family for who knows how many generations.
Ingredients Nutrition
- 236.59 ml self rising flour
- 236.59 ml white cornmeal
- 2 eggs
- 118.29 ml mayonnaise
- 236.59 ml milk
- 118.29 ml water (MORE OR LESS AS NEEDED TO ADJUST UNTIL SMOOTH LIKE A CAKE BATTER)
- In bowl add dry ingredients then mix in the eggs; mix well.
- Add mayonnaise; mix well.
- Add milk; mix well.
- Add water till smooth like a cake.
- Heat iron skillet till hot in oven.
- Remove and sprinkle bits of meal around in hot skillet.
- Pour and spread evenly the corn bread batter mixture to hot iron skillet.
- Cook at 350 degrees until golden brown and it is done.
- Bread will come away from edges when ready.
- Before you cut into pieces poke holes in top.
- Melt butter (to taste) and pour into holes in the cornbread.
- Cut bread in serving size wedges.
- *Note: You can make this recipe using yellow corn meal but add about a tablespoon of sugar to the cornbread batter.


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I was thinking about resubscribing and came across the collection being sold for $20 with 60 days of game play rather than the usual 30 when you buy a new game. Does anyone know if you can, or has tried using the games play time that come with the collection edition (60 days) and adding it to an already existing account? Or would that only apply to a newly created account.
Buy the game for $20 = get 60 days game time
Re-sub @ $15/month.....seems it would make sense to buy the collection and save $10 no?
If I remember correctly, I was able to do this with Lineage 2 when they had an anniversary edition on sale for $10, me and some friends bought a few each and added the time to an already existing account.....Would this work in this situation?
i would like to know the answer to this question as well since i haven't bought TSO yet.
The 60 days of free game-play does not apply to people with an existing Everquest II account or an existing Sony Station Access account. It's only valid on new accounts.
Yah I figured that...I happened to see the box in GameStop today, and in the fine print at the bottom, it indeed does say "for new accounts only"
Oh well...was a good thought!!


text: 3D Custom Girl Developer Churns Out Xbox LIVE Game...Brian Ashcraft8/12/09 1:00amFiled to: Minimum Riskyerotic games3D custom girlCultureNsfw49EditPromoteShare to KinjaToggle Conversation toolsGo to permalink ...about interior design. Erotic game maker Tech Arts 3D is best know for PC title 3D Custom Girl, which lets users create a customized, well, 3D girl. It's newest game could not be further from that. Here is a YouTube clip of its custom girl game, and here's an example of the software in action: customized characters from Namco's iDOLM@STER. Both NSFW. Tech Arts 3D is bringing it customizing know-how to Xbox LIVE's Indie Games with an is a "housing action puzzle" called Madrism. In Madrism, players must create an interior design floor plan with all rooms accessible via door. No custom girls! Just rooms, kitchens and bathrooms. That's right, Tech Arts 3D is apparently looking to go mainstream — 80 Microsoft Points at a time. Good luck with that. Advertisement Advertisement Tech Arts 3D [Official Site NSFW] [Pic]Reply49 repliesLeave a reply


text:
code optimizing
- Status Closed
- Budget €30 - €50 EUR
- Total Bids 11
Project Description
I heve this free voice recognition application (spanish language): [url removed, login to view]?t=W251bGwsMSwxLDEsImNvbS5tZWdhbG9naWNhLmFzaXN0ZW50ZWVzIl0.
I made it but i am not good java programmer, so i want someone to optimize the code, for app to load faster, run smoothly, avoid crashes ...
I also have another problem, when the app is running in background it stills listening for voice user and executes commands, it works fine in android 2.3 and up, except in Jelly Bean that kills the activity in few seconds (i need that issue solved too)
Thats all.
Carlos.Get free quotes for a project like this
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text:
Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis
DOI: 10.1186/ar2823
© Nanki et al.; licensee BioMed Central Ltd. 2009
Received: 14 May 2009
Accepted: 5 October 2009
Published: 5 October 2009
Accumulation of B cells in the rheumatoid arthritis (RA) synovium has been reported, and it has been thought that these cells might contribute to the pathogenesis of RA by antigen presentation, autoantibody production, and/or inflammatory cytokine production. Chemokines could enhance the accumulation of B cells in the synovium. The aims of this study were to determine chemokine receptor expression by B cells both in the peripheral blood of normal donors and subjects with RA, and at the inflammatory site in RA, and the effects of chemokines on B cell activation.
Cell surface molecule expression was analyzed by flow cytometry. Cellular migration was assessed using chemotaxis chambers. Cellular proliferation was examined by 3H-thymidine incorporation. Tumor necrosis factor (TNF) production was assayed by enzyme-linked immunosorbent assay.
Significant numbers of peripheral blood B cells of healthy donors and subjects with RA expressed CC chemokine receptor (CCR)5 and CXCR3, and most B cells expressed CCR6, CCR7, CXCR4 and CXCR5. CCR5 expression was more frequent on CD27+ than CD27- peripheral blood B cells of healthy donors and RA. Synovial B cells more frequently expressed CCR5, but less often expressed CCR6, CCR7 and CXCR5 compared to peripheral blood in RA. Further functional analyses were performed on peripheral blood B cells from healthy donors. Migration of peripheral blood B cells, especially CD27+ B cells, was enhanced by CC chemokine ligand (CCL)20, CCL19, CCL21 and CXCL12. All four chemokines alone induced B cell proliferation; with CCL21 being the most effective. CCL21 also enhanced the proliferation of anti-immunoglobulin (Ig)M-stimulated B cells and blockade of CCR7 inhibited this effect. CCL20, CCL21 and CXCL12 enhanced TNF production by anti-IgM mAb-stimulated B cells. Finally, stimulation with CXCL12, but not CCL20, CCL19 and CCL21, enhanced inducible costimulator-ligand (ICOSL) expression by peripheral blood B cells of healthy donors and RA, but did not increase B cell-activating factor receptor or transmembrane activator and CAML-interactor.
The data suggest that CCR5, CCR6, CCR7, CXCR3, CXCR4 and CXCR5 may be important for the B cell migration into the synovium of RA patients, and also their local proliferation, cytokine production and ICOSL expression in the synovium.
Rheumatoid arthritis (RA) is characterized by chronic inflammation of multiple joints. As B cell depletion by treatment with rituximab, an anti-CD20 monoclonal antibody (mAb), is beneficial for RA patients [1, 2], B cells are considered to play important roles in the pathogenesis of RA. In this regard, the synovial tissue of RA patients shows abundant accumulation of inflammatory cells, including T cells, macrophages, dendritic cells and B cells [3–6]. Synovial B cells could present antigens to T cells. Importantly, rheumatoid factor-expressing B cells that are found within the synovium [7] can present any antigen in the context of an immune complex and, thereby, trigger T cells specific for a variety of foreign antigens [8]. Notably, the severity of RA correlates with levels of rheumatoid factor [9]. Furthermore, activated B cells produce inflammatory cytokines, such as TNF [10]. Therefore, synovial B cells could contribute to the pathogenesis of RA by antigen presentation, autoantibody production, and inflammatory cytokine production. One of the mechanisms for accumulation of B cells in synovial tissues relates to the interaction with chemokines produced in the RA synovium and chemokine receptors expressed by the B cells [6].
Chemokines are classified into C, CC, CXC, and CX3C subclasses based on the conserved cysteine motifs [11], and are involved in cellular migration, activation of adhesion molecules, cellular proliferation, cytokine production and regulation of apoptosis [12, 13]. Chemokines contribute to homeostatic migration as well as entry into acute and chronic inflammatory sites. Expression of chemokines and chemokine receptors in the RA synovial tissue has been extensively analyzed, and chemokines are thought to be potential therapeutic targets [14, 15]. However, the role of chemokines specifically on B cells in RA has not been completely delineated.
In this study, we examined chemokine receptor expression by peripheral blood in both normal donors and subjects with RA, and also synovial B cells from subjects with RA, and determined the functional effects of chemokines on B cells.
Materials and methods
Peripheral blood samples were obtained from healthy donors and subjects with RA after obtaining informed consent. RA was diagnosed according to the criteria of the American College of Rheumatology [16]. Synovial tissues were obtained at the time of total knee joint replacement from RA patients. Signed consent forms were obtained prior to the operation. The study protocol was approved in advance by the Ethics Committee of the Tokyo Medical and Dental University.
Chemokine receptor expression
Peripheral blood mononuclear cells (PBMCs) were isolated by ficoll-hypaque (Immuno-Biological Laboratories, Gunma, Japan) gradient centrifugation. The synovial tissue was minced and incubated with 0.3 mg/ml collagenase (Sigma, St. Louis, MO, USA) for one hour at 37°C in Dulbecco's Modified Eagle Medium (DMEM) (Sigma, St. Louis, MO, USA). Partially digested pieces of the tissue were pressed through a metal screen to obtain single cell suspensions. The following mAbs were used for FACS analysis: phycoerythrin (PE) Cy5-conjugated anti-CD19 mAb (J4.119; Beckman Coulter, San Jose, CA, USA), fluorescein isothiocyanate (FITC)-conjugated anti-CD27 (M-T271; Ancell, Bayport, MN, USA) mAb, PE-conjugated anti-CC chemokine receptor (CCR)5 (2D7; BD Bioscience, San Jose, CA, USA), -CCR6 (53103; R&D Systems, Minneapolis, MN, USA), -CCR7 (150503; R&D Systems, Minneapolis, MN, USA), -CXCR3 (49801; R&D Systems, Minneapolis, MN, USA), -CXCR4 (12G5; R&D Systems, Minneapolis, MN, USA) and -CXCR5 (51505.111; R&D Systems, Minneapolis, MN, USA) mAbs, and isotype-matched control mAbs. PBMCs or synovial tissue cells were incubated with the mAbs for 20 minutes, and then rinsed with PBS-3% fetal calf serum (FCS; Sigma, St. Louis, MO, USA). More than 5000 stained cells were analyzed with a FACSCalibur (BD Bioscience, San Jose, CA, USA).
Migration assay
Cell migration was assessed in 24-well chemotaxis chambers (6.5 mm diameter, 5 μm pore polycarbonate transwell culture insert; Costar, Cambridge, MA, USA). ECV304 cells (2 × 105) were cultured in the chemotaxis chambers for 48 to 72 hours in medium 199 (Sigma, St. Louis, MO, USA) with 10% FCS. The migration medium (Roswell Park Memorial Institute (RPMI)1640 medium (Sigma, St. Louis, MO, USA):medium 199 = 1:1, 0.5% BSA) supplemented where indicated with various concentrations of chemokines (CC chemokine ligand (CCL)20, CCL19, CCL21, and CXCL12: PeproTech, Rocky Hill, NJ, USA) was added to the lower wells. ECV304 coated chemotaxis chambers were placed in each well, and 5 × 105 PBMCs suspended in migration medium were added to the upper wells. After two hours of incubation, the membrane was removed, and migrated cells were stained with PE Cy5-conjugated anti-CD19 mAb (J4.119) and FITC-conjugated anti-CD27 mAb (M-T271). The cells were counted by FACSCalibur.
Proliferation assay
Peripheral blood CD19+ B cells were purified by magnetic-activated cell sorting microbead-coupled mAb and magnetic cell separation columns (Miltenyi Biotec, Auburn, CA, USA). Purity of CD19+ B cells was determined by flow cytometry, and was more than 95%. To block CCR7, B cells were incubated with 5 μg/ml anti-CCR7 mAb (150503; R&D Systems, Minneapolis, MN, USA) or control mAb for 30 minutes. Then, the 5 × 105 B cells were incubated in 96-well with the indicated chemokines with or without pre-coated anti-IgM mAb (2 μg UHB; SouthernBiotech, Birmingham, AL, USA) in RPMI1640 with 10% FCS at 37°C for 48 hours. 3H-thymidine (1 μCi; Amersham Biosciences, Little Chalfont, Buckinghamshire, UK) was added and the B cells were incubated for 24 hours. Afterward, the incorporated radioactivity was quantified. After the 72-hour incubation, viabilities of the cells, determined by trypan blue exclusion, were 87.3% and 80.3% without and with anti-IgM stimulation, respectively.
TNF production
Purified 5 × 105 peripheral blood B cells were stimulated with the indicated chemokines with or without coating of wells with anti-IgM mAb (2 μg UHB) in 96-well in RPMI1640 with 10% FCS at 37°C for 24 hours. Afterward, the concentration of TNF in the culture supernatant was assayed using an ultra sensitive ELISA kit (BioSource International, Camarillo, CA).
Cell surface molecule expression
PBMCs were cultured with the indicated chemokine in RPMI1640+10% FCS for 24 hrs. Afterward, the cells were stained with PE Cy5-conjugated anti-CD19 mAb (J4.119) and FITC-conjugated anti-inducible costimulator-ligand (ICOSL) mAb (MIH12; eBioscience, San Diego, CA, USA), PE-conjugated anti-B cell-activating factor receptor (BAFF-R; 8A7; eBioscience, San Diego, CA, USA), -transmembrane activator and CAML-interactor (TACI) mAb (11H3; eBioscience, San Diego, CA, USA), or isotype-matched control mAb. The stained cells were analyzed with a FACSCaliber.
Statistical analysis
Paired t test was used to compare paired samples of CD27- and CD27+ peripheral blood B cells, and peripheral blood and synovial B cells from the same subjects for chemokine receptor expression and migration. Differences in migration, fold increase of proliferation and TNF production were examined for statistical significance using the unpaired t test. All data were expressed as mean ± standard error of the mean (SEM). A P value less than 0.05 denoted the presence of a statistically significant difference.
Chemokine receptor expression by B cells
Next, we analyzed the chemokine receptor expression by CD27- B cells and CD27+ B cells from peripheral blood and synovial tissue of subjects with RA. The frequency of CD27-expressing peripheral blood B cells was not significantly different between subjects with RA and healthy donors (data not shown). The proportion of the chemokine receptor expression of RA peripheral blood B cells was similar to that of healthy donors without any statistically significant differences. As with healthy donors, CCR5 expression by RA peripheral blood CD27+ B cells was more frequent than that of CD27- B cells, and CXCR4 expression by CD27+ B cells was less frequent than that of CD27- B cells. In addition, the proportions of CCR6, CCR7 and CXCR5 expression were significantly less by CD27+ compared with CD27- B cells in subjects with RA.
TNF production
Cell surface molecule expression
In this study, we showed that significant numbers of peripheral blood and RA synovial B cells express CCR5, CCR6, CCR7, CXCR3, CXCR4, and CXCR5. The ligand chemokines, CCL3, CCL4 and CCL5 for CCR5, CCL20 for CCR6, CCL19 and CCL21 for CCR7, CXCL9, CXCL10 and CXCL11 for CXCR3, CXCL12 for CXCR4, and CXCL13 for CXCR5 has been reported to be expressed in the RA synovium [22–29]. Therefore, interactions between the chemokines and the chemokine receptors might contribute to B cell migration into the synovial tissue in patients with RA.
In the RA synovium, the proportion of memory CD27+ B cells was increased compared with peripheral blood of RA patients. The results also showed that CCR5 was expressed more frequently by peripheral blood CD27+ B cells compared with CD27-, and the proportion of synovial B cells expressing CCR5 was increased compared with peripheral blood. These results suggest that interaction between CCR5 and the ligand chemokines could contribute to the accumulation of CD27+ B cells in the synovium. Alternatively, because the migration of CD27+ B cells to all the chemokines analyzed was greater than that of CD27- B cells, the increased proportion of CD27+ B cells in the synovium might be related to their higher chemotactic activity. In contrast, the expression of CCR6, CCR7 and CXCR5 was downregulated by the synovial B cells. As most peripheral blood B cells express these chemokine receptors, it is not likely that the chemokine receptor-negative B cells selectively migrated into the synovium. Rather chemokine receptor expression might be downregulated after ligation of the corresponding ligand chemokine. Alternatively, stimulation with cytokines or adhesion molecules may downregulate chemokine receptor expression in the synovium.
The present study showed that stimulation with chemokine regulates peripheral blood B cell proliferation. Previous studies showed the presence of germinal center-like structures in the RA synovium [30], somatic hypermutation of the Ig variable region genes, B cell clonal expansion, and a skewed Ig repertoire in the synovium [31, 32]. Collectively, these results suggest that synovial B cells might be antigenically stimulated at the inflammatory site. Based on such B cell stimulation in the synovium, the interaction between chemokines and chemokine receptors, especially CCL21 and CCR7, might also contribute to B cell proliferation. There is an evidence that follicular dendritic cells in the RA synovium produce CXCL13, a ligand for CXCR5 [29]. Interaction with the expressed CXCL13 and CXCR5 on B cells might contribute to the formation of the germinal center-like structures in the synovium.
Stimulation with CCL20, CCL21 and CXCL12 enhanced TNF production by anti-IgM mAb-stimulated peripheral blood B cells suggesting that chemokine stimulation in the RA synovium might also increase TNF production by synovial B cells. It is widely known that TNF plays important roles in the pathogenesis of RA and blockade of this cytokine is an effective therapy for RA [33]. Moreover, CXCL12 upregulated ICOSL expression on peripheral blood B cells. ICOSL could interact with inducible costimulator (ICOS), which is expressed by activated T cells [34]. We showed previously that ICOS expression was upregulated on RA synovial T cells [35]. Thus, upregulated ICOSL on CXCL12-stimulated B cells could augment T cell stimulation in the synovium. Taken together, interaction between chemokine and chemokine receptor might play roles not only on B cell migration into the synovium, but also B cell activation in the synovium. In this regard, we reported previously that CXCL12 enhanced cellular proliferation and expression of cytokines and activation markers by peripheral blood T cells [36, 37], and that CCL2, CCL5 and CXCL12 upregulated the expression of cytokines and chemokines by fibroblast-like synoviocytes from RA [38]. Thus, chemokine stimulation in the RA synovial tissue could play an important role on the chronic immune activation found in this tissue.
CCR5, CCR6, CCR7, CXCR3, CXCR4, and CXCR5 might be important for B cell migration into the synovium of RA. Chemokines are suggested to contribute to B cell migration as well as their proliferation, cytokine production and ICOSL expression in the RA synovium.
B cell-activating factor receptor
bovine serum albumin
CC chemokine ligand
CC chemokine receptor
Dulbecco's Modified Eagle Medium
enzyme-linked immunosorbent assay
fetal calf serum
fluorescein isothiocyanate
inducible costimulator
inducible costimulator-ligand
- Ig:
- mAb:
monoclonal antibody
- PBMCs:
peripheral blood mononuclear cells
phosphate-buffered saline
rheumatoid arthritis
Roswell Park Memorial Institute
standard error of the mean
transmembrane activator and CAML-interactor
tumor necrosis factor.
We thank Fumiko Inoue and Aya Sato for the excellent technical support. This work was supported in part by grants-in-aid from the Ministry of Health, Labor and Welfare, and the Ministry of Education, Science, Sports and Culture, Japan, and the Japanese Ministry of Education, Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases.
Authors' Affiliations
- Edwards JC, Cambridge G: Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford). 2001, 40: 205-211. 10.1093/rheumatology/40.2.205.View ArticleGoogle Scholar
- Cohen SB, Emery P, Greenwald MW, Dougados M, Furie RA, Genovese MC, Keystone EC, Loveless JE, Burmester GR, Cravets MW, Hessey EW, Shaw T, Totoritis MC: Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 2006, 54: 2793-2806. 10.1002/art.22025.View ArticlePubMedGoogle Scholar
- Lundy SK, Sarkar S, Tesmer LA, Fox DA: Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res Ther. 2007, 9: 202-10.1186/ar2107.PubMed CentralView ArticlePubMedGoogle Scholar
- Kinne RW, Stuhlmuller B, Burmester GR: Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther. 2007, 9: 224-10.1186/ar2333.PubMed CentralView ArticlePubMedGoogle Scholar
- Lutzky V, Hannawi S, Thomas R: Cells of the synovium in rheumatoid arthritis. Dendritic cells. Arthritis Res Ther. 2007, 9: 219-10.1186/ar2200.PubMed CentralView ArticlePubMedGoogle Scholar
- Mauri C, Ehrenstein MR: Cells of the synovium in rheumatoid arthritis. B cells. Arthritis Res Ther. 2007, 9: 205-10.1186/ar2125.PubMed CentralView ArticlePubMedGoogle Scholar
- Randen I, Brown D, Thompson KM, Hughes-Jones N, Pascual V, Victor K, Capra JD, Forre O, Natvig JB: Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J Immunol. 1992, 148: 3296-3301.PubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
----- Original Message -----
To: email@example.com
Sent: Monday, July 26, 2004 9:15 PM
Subject: Re: Re: [iris-photos] photo
requests_for Will Warner
Pearl, I just did a search, and here's the description
listed at garden eureka: BOBBIE ALLEN J. Allen 1987 40 M Light Blue
w'White Center Area Standards Light Blue w'White Area Falls Blue Tipped
Beard TB SltSwtFraSounds like the first one to me. Thanks for
posting it, and thanks to everyone elso who's been posting them too.
I really appreciate it. thanks. Will Warner> >
From: "Pearl Doyle" <firstname.lastname@example.com>> Date: 2004/07/26 Mon
PM 07:59:35 CDT> To: <email@example.com>>
Subject: Re: [iris-photos] photo requests_for Will Warner> > I
don't know how much help this will be. I took pictures at Clark Garden
this spring and both of these were marked Bobbie Allen, James R. Allen
1987. If you can get a description maybe we both will know which is the
correct picture.> ----- Original Message -----
> From: email@example.com > To:
firstname.lastname@example.com > Sent: Monday, July 26, 2004
11:58 AM> Subject: [iris-photos] photo requests>
> > I got some new iris at a local iris sale, and
can't find any pics. Anybody > have any of
these? Please let me know if I'm spelling it wrong, I'm
> reading these off iris leaves :). Thanks in
advance. Will Warner> Platinum
Plus> Fancy Notions> Navajo
Blue> In Your Dreams> Memory
Maker> Recurring Fantasy> Ozark
Rebounder> Motley Fool>
Infrared> Maid of Avalon>
Decker> April Jewel> Champagne
Caviar> Principles> Kelly
Lynn> Helen Cochran> Deanna's
daughter> Margaret> rebecca
Derrett> Bobbie Allen> Clearwater
River> America the Beautiful> Go
Around> Pauline Roderick> Zany>
> > >
Yahoo! Groups Sponsor
> > > >
Yahoo! Groups Links> > a.. To visit your
group on the web, go to:> http://groups.yahoo.com/group/iris-photos/>
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> c.. Your use of Yahoo! Groups is subject to
the Yahoo! Terms of Service. > > >
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Well, this is a panel discussion. Except you don't have to go anywhere to see it and you don't have to write your question on a note card and give it to someone to give to the moderator.
Send it to me (email@example.com). Or comment and ask the panelists directly.
Nothing is more important to San Diego than its water supply. We import the vast majority of this precious resource from hundreds of miles away through a system of rivers, pumps, canals and reservoirs. Along those routes, more and more people are building homes and businesses and challenging our rights to bring so much water in from so far away.
The city of San Diego is right now discussing how it should charge consumers for water. Officials have had trouble explaining why they can't — or don't want to — implement a tiered-rate structure that rewards conservation and forces major consumers of water to pay for it. As reporter Rob Davis deadpanned the other day: "Someone at City Hall must really like San Diego's existing water rate structure."


text:
Economy Inn
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
- Suites
- Free High-Speed Internet
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Travel Blogs from Longview
Waterfall Alley
... just so I could remember how much cycling hurts.
Today is wet and we are visiting " Herman the Sturgeon" who is 10 ft long in a hatchery and the salmon ladder at the Bonneville Dam. Then onto Waterfall Alley in the mist.
Caution: I reckon one of those Breakfast burritos here has enough calories to last at least 2 days.
xx ...
Day 3 - Bellingham, WA to Toledo, WA
... evening is that I was having so much fun that I forgot to take a picture of these guys. Spillit even told me about recently losing his wife. He couldn't remember how long they were married in total because he married her three times! He said they couldn't get along when he rode but they couldn't stand being apart either so they would remarry every few years. I swear, Spillit and his buddy looked almost exactly like ZZ Top, beards and ...
Day 12: Working, traffic and camping
... thanks a million mum for waking up at 12 midnight for like an hour omhelp! You're a champ! :) after working for about an hour or so trying to get it all fixed up, I had breakky and read until Kels and Esther Berends came at 11. We left and picked Laura and thn headed off to meet up with Ranelle and Jo before we left for sea quest national park. It should have taken us 5 hours ...
The end of the trail (Lewis and Clark's)
... at all once it's healed.
We stayed at Shari's for about 45 minutes, and then headed south. We stopped at the Tacoma Costco and got gas and lunch, and then continued on our road.
Our goal was to see Astoria, OR, where the Columbia River flows into the Pacific Ocean. We got there about 4:45. They had a maritime museum, but it closed at 5, so we went to the Astoria Column, which didn't close until ...
Amaya's Farm
... It was warm, but buggy, and the noise from the highway and the railway was LOUD! I thought I'd never sleep, but instead, I never heard anything! Slept great...thanks to new pads from REI.
Today, rather than beeline for Portland, we took a detour around Mt. Hood in order to go through Rhododendron, where son Connor lived for a couple of months last year. He was helping to renovate a pizza place there...from what we could see, it still ...


text:
News Alert system based on Social Graph
This project received 4 bids from talented freelancers with an average bid price of $22 USD / hour.Get free quotes for a project like this
Project Budget$2 - $40 USD / hour
Total Bids4
Project Description
We need you to build a full system that finds articles about you, your friends and colleagues, and anyone else you care about and notifies you minutes or hours after they're published. Your system will:
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- Forbes
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text:
Statement of Dave McCurdy, President & CEO, Alliance of Automobile Manufacturers, Regarding a New, Nationwide U.S. Fuel Economy Standard
Dec 01, 2007, 00:00 ET from Alliance of Automobile Manufacturers
WASHINGTON, Dec. 1 /PRNewswire-USNewswire/ -- "The Alliance commends Congressional leaders for reaching agreement on an aggressive, nationwide fuel economy program. This agreement reflects much hard work and tough negotiating by many parties. "Importantly, this agreement establishes nationwide fuel economy requirements for the next 12 years and beyond. Upon adoption of this legislation, Congress will have established aggressive, nationwide fuel economy requirements, concluding a longstanding debate. "As we understand the agreement, these tough, national mileage standards merge provisions of both the Senate and House CAFE proposals. The agreement includes a number of necessary measures to help make the overall regulatory program more realistic and reasonable. Automakers are pleased that Congressional negotiators ultimately accepted the need for practical provisions like separate car and light truck standards and incentives for building more autos that run on non-petroleum-based fuels. The bill also provides mechanisms that help automakers balance the natural ups and downs of the product cycle. "This historic legislation would not have been possible without the efforts of auto workers, dealers, suppliers, user groups and industry allies in the business community -- whose leaders and members participated in this process. One in 10 jobs in the U.S. is dependent on the auto industry. Indeed, no other industry is linked so much U.S. manufacturing or generates more retail business and employment. "We believe this tough, national fuel economy bill will be good for both consumers and energy security. We support its passage." CONTACT: Charles Territo
SOURCE Alliance of Automobile Manufacturers


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Post some pics of your set ups with speeds please ! Let's see em !
Post some pics of your set ups with speeds please ! Let's see em !
330's with a 400gn arrow.
Mathews HTR 70/29.5 / Axcel Accutouch Pro / Mathews QAD / Tight Spot / Black Eagle Arrows / DRT
Very nice ! Let's see some more !
Must wait for rattler sideplates first. =)
I'm waiting for my roadtrip to get my new threads from Tony219er in 3-4 weeks before I post any pics of mine. LOL!
Bowtech Boss 28"/60# in BlackOps
HHA OL-5519 with 2nd/3rd axis
LimbDriver Micro Elite with hunter blade
Nice ! Any body got one set up for some 3d ? Keep em comin !
Nice looking bow, but everybody is saying there the fastest bow on the market.. my MR5 would eat those rpm's in speed. I'm slinging a 402 grain 7595 GT. at 346-348, an I can go faster if I drop my arrow weight an lengthen my draw length.
2016 Vicotory 37 Red
2017 Victory 37 Sunset Pink On Order
Bowtech Boss 28"/60# in BlackOps
HHA OL-5519 with 2nd/3rd axis
LimbDriver Micro Elite with hunter blade
I shot psychobabys on Saturday quite a bit and it's a shooting machine , he's got a 50lber maxed at 52 and it is sweet ! I was impressed at how smooth the draw is and how quiet and most of all accurate ! I shot it a lot better than my carbon spyder 34 , his. Ibo s at about 345 , a little slow but who cares they are that nice ! Let's see some more bows !
Don't have a picture, but at 53#, 30 DL and a 360 grain arrow, I am at 308 fps. Weird part is when I first bought it, I was getting the same speed with a 342 grain bare shaft arrow.
Give me a couple weeks, still waiting on my riser and stabs to get done from Ultimate Finishers.
60# Bowtech Boss Black
Are you shooting a short draw length on purpose just to slow
Your bow down?
2015 Darton Executive
Excalibur Matrix 350 SE. Vortex XBR ....
Ramcats,Magnus Black Hornet's
Stryker Solution LS, Vortex XBR, Zombies..Hidden Content
How are the stock strings holding up on those new death machines? Great looking bows, cant wait to shoot one!
Must be an 80lber to get those speeds I am guessing. Or you have the worlds fastest MR5..either or.
It is at 80# an I'm at 30 1/2" draw length, my draw length is normally 31 1/2, but at the 30 1/2 it feels great, but I can easily get 360 fps if I lengthen my draw weight an lower my arrow weight. An I could go even faster, "2 fps" if I get a 65% let off module.
Here is my rpm 360 with tony219er cables and strings and my brand new rattler desert Kirinite grips.
Bowtech Prodigy | Bowtech BTX-31 |
"Aim Small Miss Small"
Very nice they look great !!! Keep them coming ,those are some very nice set ups , the camo looks really good this year way better than before IMO !
wifes rpm with her FLO pink strings pics do it no justice.
2017 Denali xpedition 62lbs 513 /277
15 eva shockey 42.3 lbs 27'' 316/259fps
2011 elite pulse
Man those rpms look like there ready to kill something ! Those black ops are very nice ! Let's see some more set ups !!!!!!!


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Does this restaurant offer highchairs for toddlers?
Can a vegetarian person get a good meal at this restaurant?
Can a vegan person get a good meal at this restaurant?
Is this restaurant appropriate for Kids?
Is this restaurant good for brunch?
Does this restaurant offer takeout or food to go?
Is this restaurant wheelchair accessible?
Is this restaurant good for dinner?
Is this restaurant good for bar scene?
Is this restaurant good for large groups?
Thanks for helping!
We so enjoyed our dinner at 306 North. The Southern elements of the cuisine were distinctive and delicious.
Julie --
It is wonderful to know you enjoyed your dinner at 306 North, and we thank you very much for stopping by! Please come back again anytime you head our way.
All the best -- Amy Cox
The spinach Salad with warm bacon dressing is fabulous. I order this every time I eat here.
Portion is big and very filling.
Joy --
We are always thrilled to welcome you back to 306 North! Thank you for continuing to come dine with us. We look forward to serving you another tasty spinach salad the next time you head to downtown Valdosta!
Our very best -- Amy Cox
Don't miss the great service, food at lunch or dinner, the buttermilk pork chops and two sides excellent for lunch, at dinner you want a good choice cut ribeye? This is the place. Sides are excellent too.
Thank you for sharing your great review about 306 North! We really enjoy serving great food with great service, and we look forward to welcoming you back soon.
Thank you again! Amy Cox, Owner
My husband and I dined here on a weeknight. Wonderful experience! I had grouper, he had steak. Both were prepared well and portion size was just right. The duck appetizer was amazing! Don't miss desert. Nice, varied selection.
Staff was pleasant and attentive without hovering.
Maggie --
Happy birthday! We are so glad you had a wonderful experience at 306 North, and we thank you for choosing to spend the special day with us. Please come back again!
Best wishes -- Amy Cox, Owner
The Gouda Grits and Shrimp was delicious. The service was a little slow. Think we were overlooked. One server thought the other server was taking care of us. We got to park right out front.
Beth --
It is great to know you enjoyed our Shrimp & Grits, but I apologize deeply for our service not performing as it should have during your visit. We are addressing the shortcoming, and I hope you allow us another opportunity to do better for you the next time you're in Valdosta.
Thank you for having lunch with us!...
food was amazing. Service was a little slow. The seasonal cheese plate is really good. I had the burger and it was exceptional. They also have a good variety of beer and cocktails. They made a wonderful cucumber gimlet
Thank you for dining with us at 306 North! We are so glad you found our food amazing, but I am sorry that our service was a bit off. We'll work to make all needed adjustments, and we hope to demonstrate much more prompt efforts the next time you come our way.
Thank you again! Amy Cox
We'd been referred to 306 North by a friend who'd eaten there, so we knew the food would be good. However, we did not expect this restaurant to be such a gem. We not only enjoyed the food, but the service and the ambience was charming.
My husband and I were seated in a small room near the bar, as...
We are absolutely delighted to read your review and know you found 306 North to be worth the stop! Thank you for giving us a try while you were in Valdosta, and we look very forward to serving you again the next time you pass through.
Our warmest regards,
Amy Cox
We just had a New Years Eve dinner at 306 North. Great meal and service. Gracie, a math Ed student at the university, took excellent care of us, She was very thoughtful paying attention to all of our needs. I wish we could be here in the summer to eat on the patio. Just perfect!
It was a pleasure to serve you a great New Year's Eve dinner at 306 North! Thank you for enjoying your last meal of 2016 with us. We hope for all the best for you in 2017! Please come back again.
Happy New Year,
Amy Cox
Took my wife here on our way back from Florida recently, hoping to get in a nice dinner before heading off to our hotel. Recent reviews for 306 North were good, but I didn't expect things to turn out as good as they did. What more can you ask for: Great tasting food served in adequate proportions and delivered piping...
Thank you to you and your wife for having dinner with us at 306 North! We are delighted to know you enjoyed your experience at our "little jewel," and we look forward to serving you again the next time you come to Valdosta.
Our very best,
Amy Cox
My birthday lunch, my sister and niece took me to this lovely place. I wanted a Med Rare chopped steak with Gouda grits and asked if I could substitute the other side choice with the side offered with the special: carmelized Brussels sprouts. She doubted as chef was off and kitchen really busy, but would ask. So, being overwhelmed with...
I am very sorry to read your comments and know that we fell very short of the high standards of customer service we uphold. We certainly should have done better, and I will review your comments with our team to make sure we improve.
Happy belated birthday and, again, my deepest apologies.
Amy Cox
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.
I don't seem to see your hours posted on your website? We are coming through town Friday night around 8 pm. Would you post your operating hours? Thanks!
do you need reservations for a Friday night?
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June 2010 Releases, part 1
June 1, 2010 at 8:43 pm 16 comments
Blame it on the holiday, but it didn't click with me until this evening (Tuesday) that book release day was today! Luckily, this post was mostly done. So, here are the books that are due out today and next week.
June 1, 2010: Chimera by Rob Thurman
Here is a book description:
June 1, 2010: Bullet (Anita Blake series, book 19) by Laurell Hamilton.
June 1, 2010: Demon Hunts (The Walker Papers, book 5) by CE Murphy
Here is the description from the author's site:
June 1, 2010: Skin Tight (Skin series, book 2) by Ava Gray
Here is the description from the publisher's site:
June 1, 2010: Lightborn (Darkborn trilogy, book 2) by Alison Sinclair
June 8, 2010: Dragonsoul (Havemercy series, book 3) by Jaida Jones & Danielle Bennett
Here is a book description:
June 8, 2010: Raised by Wolves by Jennifer Lynn Barnes
Here is a book description:
Cover award for the month has to go to the absolutely beautiful Lightborn cover. I also really loved the cover on the first book in the series, Darkborn. (The story was really good, as well. 😉 ) Can't wait to see the final cover in the trilogy! My library has Lightborn on order, but for some goofy reason, I can't request it yet.
However, I do have Bullet and Raised by Wolves on request at the library. I'm behind on The Walker Papers, but hope to catch up soon, probably on audio. Chimera, Skin Tight, and Dragon Soul will probably be purchases, unless the library gets them in really soon! Because I'm just impatient like that.
Did I miss any books coming out this month that you're looking forward to?
To see what other books were released in June, check out my June 2010 Releases, part 2 post.
For information on other future releases, check out my Upcoming Releases page.
For information about other previously released books, check out my Released in 2010 page.
Entry filed under: 2010 Releases. Tags: Alison Sinclair, Anita Blake series, Ava Gray, Bullet, CE Murphy, Chimera, Darkborn trilogy, Demon Hunts, Dragon Soul, Havemercy series, Jaida Jones & Danielle Bennett, Jennifer Lynn Barnes, Laurell Hamilton, Lightborn, Raised by Wolves, Rob Thurman, Skin series, Skin Tight, Walker Papers.
16 Comments Add your own
Oh Renee, you're absolutely correct, that is one gorgeous cover. I don't have any of those books on my TBB list, although they all look quite interesting.
I have a couple on my June list, but the two books I'm definitely buying are Love in the Afternoon by Kleypas and the one I can't wait to get my hands on is Kraken by China Mievielle.
Woo-hoo! Nothing I'm waiting on. (How sad is it that I'm happy when there aren't books to tempt me?! Hee hee)
I just ordered Skin Tight for a Pick me up at that local B & N. Can't wait to read that one!
I'm behind with The Walker Papers series too – I have the fourth book on my TBR list and am hoping for a return by Cerunnos (sp?). And another Anita Blake? *GULP* I think I'm two behind on that series…
Dragon Soul is on my library hold list. Am looking forward to that! Oh, and I quite like the sound of Raised By Wolves!
Thank you Renee! My TBR list would also thank you but it's sulking from an influx of book title 🙂
Chimera!! I'm looking forward to that one 🙂
and oh, during the Young Adult panel at RT, they were recommending the Jennifer Lynn Barnes 🙂
[…] releases and more: Lily (m/m romance), Renee (UF/PNR), Literary Escapism (UF/PNR, interviews, etc), and Elisa […]
[…] see what other books were released in June, check out my June 2010 Releases, part 1 […]
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Fangraphs Lists the Top 10 Braves Prospects
A day after reviewing the last few years of Braves drafts, Marc Hulet of Fangraphs just posted his list of the Braves' top 10 prospects. I'll just contrast them with John Sickels' list from October, on the right:
|Marc Hulet
|John Sickels
|1. Jason Heyward
|1. Jason Heyward
|2. Freddie Freeman
|2. Freddie Freeman
|3. Julio Teheran
|3. Julio Teheran
|4. Arodys Vizcaino
|4. Randall Delgado
|5. Craig Kimbrel
|5. Arodys Vizcaino
|6. Randall Delgado
|6. Craig Kimbrel
|7. Ezekiel Spruill
|7. Mike Minor
|8. Christian Bethancourt
|8. Christian Bethancourt
|9. Cody Johnson
|9. Zeke Spruill
|10. Adam Milligan
|10. J.J. Hoover
The top 3 are identical and the next 3 are just in a different order. And both agree that Zeke Spruill and Christian Bethancourt are in the top 10. Marc Hulet's Cody Johnson pick is a bit of a lark -- he admits, "At this point, he's a long shot to be an impact player in the Majors but he's fun to follow." Sickels has Kody at #19. On the other hand, Hulet doesn't rank Mike Minor, just a day after writing, "He projects to be a solid No. 3 starter if everything clicks."
The upshot of both lists, of course, is that the Braves have some great pitching depth: Teheran, Vizcaino, Kimbrel, Delgado, and Spruill are all high-upside, and guys like J.J. Hoover and Mike Minor and Cory Gearrin and others for depth. Offense is a bigger question mark: Milligan's got nice potential, and Kody's still young, but once we graduate Heyward and Freeman our upper minors are going to be awfully thin of hitters. Still, you can never have too much pitching.
So how do you feel about Hulet and Sickels's lists? Who'd they miss?
Braves Land Eric Hinske
This Wednesday evening in Atlanta, we've got word from Scott Miller of CBS Sports that the Braves have agreed to terms on a one-year deal with lefty four corners reserve Eric Hinske. Terms are as yet unreported, and the deal is pending a physical. Hinske can certainly help the Braves; he's a plus defender at first base and in both outfield corners, so his versatility will be a boost to a team that's got question marks at all three of those positions. He brings some modest sock from the left side as well.
That said, the signing concerns me quite a bit as well. We got a tweet from MLB.com's Mark Bowman earlier today: "Braves GM Frank Wren said he is just looking for one more small piece to fill his offensive needs. Basically needs a primary pinch hitter." Well, that's Hinske, and Hinske is decidedly NOT the piece de resistance that Wren still needs to complete his offensive rebuild. Hinske's .337 career wOBA makes for a solid bench player and occasional starter, but the offense still needs another cog. The combination of Hinske, Melky Cabrera, Matt Diaz and Jason Heyward between the two corner outfield spots simply does not impress me. I don't view any of those four as regular players at this point, and it's not as if you can combine all their virtues and make two starters. Even if Heyward bursts right out of the gate as a starting-caliber player (which is a mighty risky bet, to say the least), that still leaves left field as a weak spot, and the Braves' isn't a strong enough lineup up and down to compensate for said soft spot. Perhaps you could parlay Hinske's platoon virtues (.804 career OPS vs. RHP, compared to .666 vs. LHP) into a job share with Diaz, but a platoon on one corner and a rookie not even old enough to legally drink on the other corner? With no backup plan to speak of if somebody gets hurt or fails to produce? I don't like it.
Something is odd with Wren's strategy, because he's got this obvious need for another hitter, and even if Hinske's deal is worth $3-4 million, payroll is still going to fall in the low-80s. Would there not be room for, say, Johnny Damon at perhaps $7 million, which would keep guaranteed payroll under $90 million, and under $95 million even if Takashi Saito and Troy Glaus reach all their incentives? Let's hope so, because as it stands right now, the Braves are going to have count on everything going just right if they want to keep pace with Roy Halladay's Phillies and Jason Bay's Mets, and even then it might not be enough.
Adrian Beltre's BoSox Discount
I was a late, qualified addition to the miniscule Beltre-to-the-Braves bandwagon. He's a big-time defensive third baseman with enough power to make his bat above average, particularly out of the awful pitcher's park in Safeco, though his bad on-base percentage negates a lot of his offensive value. He's really the only player who would be able to convince Chipper to move off third again, and considering our utter lack of organizational depth at the position, we're probably eventually going to have to fill the hole there from the free agent market -- regardless of whether Chipper's still on the team.
So I saw Beltre as someone who potentially filled one of our holes at the corners, even though moving Chipper to first would make Troy Glaus a positionless man. Anyway, the slight air in my tires was just deflated last night, when Adrian Beltre turned down more money to play for the Red Sox, accepting nothing more than a one year, $9 million contract with a $5 million player option for 2011. This is such peanuts that I'm slightly shocked -- if he takes the option, at 2 years, $14 million, he's basically earning Mark DeRosa money. But I doubt that he will, because $5 million for a player who's just coming off a $64 million contract is basically an insultingly low amount of money. So he's taking a gamble on the Red Sox's playoff chances and the U.S. economy recovering.
I wish we were a good enough team to persuade big-time players to sign for huge discounts.
Speaking of Other Sports...
The Falcons just finished their year 9-7, a few months after the Braves finished 86-76. The Hawks are 21-11, and the Thrashers are 18-17-6. Is this the first time that all four Atlanta major sport teams have been over .500 at the same time, like, ever? Any of our scholars want to check on that?
It sure is a good day to be from Atlanta!no comments


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Used Chrysler cars for sale in Westminster
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Chrysler 300C 3.0 CRD V6 5dr
At some point this vehicle was damaged and written off by the insurer because it was uneconomical to repair.
The level of damage can vary depending on the vehicle's age and value, so Category C vehicles are often put back on the road.
This write off data was provided by a third party when the advert was placed. Please check all details with the seller. The write off category indicators are provided for your assistance, but the presence or absence of an indicator in an advert, should not be relied upon by you to indicate the status of a vehicle. You are strongly advised to obtain a full vehicle history check before making an offer on a vehicle. Auto Trader Limited, or its data supplier, will not accept liability for any information provided for this write off data.
The car don't have any problems the accident was a peace of other car on A12 I hit and the suspension was affected the ianurace try to put the price down I have all the services …


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Roberts Brothers Construction in Sarasota
Our Licensed Home Remodeling company has hundreds of satisfied Customers throughout Sarasota, Manatee & Charlotte Counties. Browse a few of our projects Here & Contact Us for a Detailed Estimate on your Remodeling needs.
Kitchen RemodelingRoberts Brothers Construction in Sarasota offers Custom Kitchen Remodeling throughout Sarasota, Manatee & Charlotte Counties. Learn More
Bathroom RemodelingOur Licensed Bathroom Remodeling Company can help with Custom Vanity installation, new Countertops & faucets. Learn More
Home AdditionsRoberts Brothers Construction offers many Home Additions including Garages, Master Suites, In-Laws, Home Theaters & more. Learn More
WHO WE AREHome Remodeling Pros Since 1985
As lifetime residents and a well established family, the Roberts Brothers Family prides themselves on their reputation and deep commitment to the area and strive to provide only the best of construction services to their friends, neighbors and newcomers fortunate enough to live on the Jewel of the Gulf Coast.
Roberts Brothers Construction, Inc is a leader in Kitchen Remodeling throughout Sarasota, Manatee & Charlotte Counties. Our Licensed Kitchen Remodel Company can help you create the living space you've always wanted.
We use a 3D design software that allows you as the homeowner to visually see how your new space will be laid out. This gives you the opportunity to swap cabinet colors, kitchen countertops, back splashes, appliances, and more to see which fits your lifestyle & family the best.
Roberts Brothers Construction in Sarasota offers customized Bathroom Remodeling plans & ideas throughout Sarasota, Manatee & Charlotte Counties. Our Licensed Remodeling Company uses the highest quality products from trusted Remodeling Companies across the County. We can help redesign your Bathroom into a modern, stylish & luxurious room.
Whether you need need to remodel all your bathrooms or renovate your master bathroom, you can trust on Roberts Brothers Construction in Sarasota to manage your home remodeling project on time & effectively. With over 30 Years of service in Sarasota & Manatee County, an A+ Rating BBB and hundreds of satisfied Clients, Roberts Brothers is the remodeling company to call.
Our Remodeling Company is a leader in Home Additions throughout Sarasota, Manatee & Charlotte Counties. Roberts Brothers is a Licensed Home Additions Company that can help you redesign your home or completely re-create practically any living space into a modern, stylish & luxurious room.
Roberts Brothers Construction knows that when homeowners throughout Sarasota & Manatee Counties call us for a Home Additions Estimate, it can drastically increase their homes value. We can help with reconfiguration of floor plans, movement of walls, adding garages, in-law suites and more.
Roberts Brothers Construction knows Garage Additions or Garage Renovations can not only raise the utility of your home, but greatly improve the overall home value and set it apart when it comes time to sell.
Our Company has the experience needed to fulfill any garage plan request including 2 & 3 Car Garages, adding an Apartment above an existing structure and more.
Garages come in all shapes and sizes and they can be an attached garage, attached with double doors, detached garage, or have a breezeway. Even if you already have a garage, Roberts Brothers can help you renovate it to a better space.
Below are a few projects Roberts Brothers has completed in the past year. View our entire collection Here.
What People Say About Us
We are so pleased with our patio enclosure and the way the whole project was handled, and we hope you will add our names to your list of references, for we have only good things to say of our association with you.
We would like to thank everyone at Roberts Brothers and your subcontractors, for the fine job you did. I have been even more impressed with the fine post-completion services you have provided in fixing the few problem areas we have encountered. We were particularly impressed with John getting an electrician to the house within 2 hours after I discovered a wiring problem.
I want to thank you for the prompt and efficient manner in which you handled the problem we had with the window. In today's world of business, many organizations forget the importance of follow-up and customer relations. You and your organization certainly has not! Thanks again and you can be assured that I am recommending you to our friends.
We are enclosing the balance due. We are both extremely satisfied with the beautiful bathroom which looks like a million dollars. Every one involved was friendly and courteous. The bathroom was left completely clean at the end of each working day. Your primary concern was our complete satisfaction. Your name and that of Fox plumbing will be added to the Papillion list of recommended suppliers that is provided annually to owners.
Mary Ann and I are very pleased with the final results. Your team's careful work habits were very much appreciated. It was nice to meet the Roberts Brothers and some of their sons on the job. John mentioned that he would find more of the floor tiles for us and deliver them just in case we might need them for future repairs. We will be happy to continue to recommend your firm to our friends. Suggestyour mail us a few business cards.
As our remodeling project is now completed, I want to thank you for an excellent job, well done. The whole process was executed in a most professional and timely manner, and the small modifications to the original plan were willingly and cheerfully incorporated. I would like to single our your brother John for a special thank you for the way he supervised and carried out the various tasks. He is clearly an expert craftsman and very much a gentleman. I wish your company all success in the crowded, and often not to professional, remodeling business.


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A drug addiction to painkillers is often referred to as an opioid addiction. An opioid is a synthetic drug that mimics opiate drugs and can be extremely addictive. It can be very hard to break an opioid addiction, primarily because of the effects these drugs have on chemicals in the brain. Opioids directly affect the way the brain produces dopamine, Read More
Helping Yourself Every Day
Three Reasons Why Corian Countertops Should Be Handled With Kid Gloves
Corian countertops are a less-expensive alternative to granite and marble countertops because they have very similar appearances, textures and benefits. Unfortunately, this countertop material is not for everyone as it needs to be handled with kid gloves. There are at least three reasons why you need to be careful if you have or if you choose Corian for your countertops. Read More


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Great Lakes issues to take center stage
Great Lakes Day in Washington, March 2, 2005
Ann Arbor, Mich. – How will the Great Lakes fare in Congress this year? What is being done to harmonize Great Lakes priorities through the Great Lakes Regional Collaboration Initiative? What perspectives do our regional, national and binational leaders have on Great Lakes restoration, protection and sustainable use?
Insights into these and other issues will be provided at Great Lakes Day in Washington, March 2, 2005. Members of Congress, state and regional leaders, senior officials and top aides will share their perspectives on the challenges facing the world's greatest freshwater resource and what needs to be done to address them. Confirmed speakers include Chicago Mayor Richard Daley, U.S. Rep. Candice Miller (R-MI), Toronto Mayor David Miller, and Benjamin Grumbles, U.S. EPA assistant administrator for water.
"Momentum on Great Lakes issues has been building over the past year, with a flurry of legislative and policy initiatives coming out of Washington and the Great Lakes region," said Tom Huntley, chair of the Great Lakes Commission. "Great Lakes Day affords us an opportunity to take a closer look at these issues and to introduce our member states' priorities for addressing them."
Sponsored by the Great Lakes Commission and the Northeast-Midwest Institute, this annual event provides a snapshot of where things stand in Great Lakes policymaking and a preview of what's to come during the 2005 session of Congress. It will also feature the release of the Commission's 2005 Great Lakes Program to Ensure Environmental and Economic Prosperity, with recommendations for federal legislation and appropriations based on the restoration priorities of the region's governors and the member states of the Great Lakes Commission.
The day begins with the Great Lakes Congressional Breakfast, sponsored by the Great Lakes Commission and the Northeast-Midwest Institute, and featuring presentations by members of Congress and regional leaders. Immediately following will be the Great Lakes Issues Briefing, sponsored by the Great Lakes Commission and featuring in-depth presentations by senior officials and top congressional aides. See the accompanying agendas or view them online at projects.glc.org/greatlakesday/.
Register now for this insider's look at key Great Lakes issues! All events are open to the public; registration fees will be waived for members of the news media. For media registration, please call 734-971-9135 or use the online registration form at projects.glc.org/greatlakesday/.
For immediate release: March 2, 2005
Contact: Jon MacDonagh-Dumler, email@example.com, office: 734-971-9135
The Great Lakes Commission, chaired by Lt. Gov. John Cherry (Mich.), is an interstate compact agency established under state and U.S. federal law and dedicated to promoting a strong economy, healthy environment and high quality of life for the Great Lakes-St. Lawrence region and its residents. The Commission consists of governors' appointees, state legislators, and agency officials from its eight member states. Associate membership for Ontario and Québec was established through the signing of a "Declaration of Partnership." The Commission maintains a formalObserver program involving U.S. and Canadian federal agencies, tribal authorities, binational agencies and other regional interests. The Commission offices are located in Ann Arbor, Michigan.
The Northeast-Midwest Institute is a Washington-based, private, non-profit, and non-partisan research organization dedicated to economic vitality, environmental quality, and regional equity for Northeast and Midwest states. Formed in the mid-1970's, it fulfills its mission by conducting research and analysis, developing and advancing innovative policy, providing evaluation of key federal programs, disseminating information, and highlighting sound economic and environmental technologies and practices. The Institute is unique among policy centers because of its ties to Congress through the Northeast-Midwest Congressional and Senate Coalitions. Co-chaired by Senators Susan Collins (R-ME) and Jack Reed (D-RI), and Reps. Steven LaTourette (R-OH) and Marty Meehan (D-MA), the bipartisan coalitions advance federal policies that enhance the region's economy and environment.


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Browse, compare and enquire about new caravans, motorhomes, camper trailers and RVs
With an excellent outdoor kitchen, the Titan Eclipse 560 is well-equipped to live the good life, inside and out.+MORE
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UNDER CONTRACT ... Lowest Price Around!
Brand New Shower Pop Top with Air and Battery.
1760 FKST off road Panther with cutaway rear, coil independent suspension, DO-35 Hitch, 16" wheels.
Tare: 2061kg, ATM: 2600kg, Ball: 194kg.
Queen island bed, dinette, combo shower and toilet.
Fabulous interior with hi gloss furniture and leather upholstery,
Waeco 110 12v fridge, built in microwave, water filter, 3 + 1 cooktop/grill.
Gas/240v hot water system, Jabiru air conditioner, 12v LED lights.
Fusion radio/CD/DVD player, Winegard antenna.
Battery, Anderson plug, 130 watt solar pane.
Black checker plate protection, stoneguard, 2 x jerry can holders.
Roll out awning with picnic table, external 12v and 240v power points, gas bayonet and speakers.
Tough as can be outside, sleek and stylish inside!
Check out our price reduction.
If you really want to get right away, what could be better than this brand new pop top.
Inspect today, quote Stock# GS21
Camperagent RV Centre, a family run business for 20 years, buying selling and consigning all types of holiday vehicles, incl new and used caravans, pop tops, campers, motorhomes and RVs.
Easy access on the main highway, 25 mins north of the CBD.
The largest RV Sales and Service yard in South Australia,
We would love to help you find your next home on the road.
Open 7 days, till 3pm on weekends and public holidays..(Open on Sundays North Yard Only). 750 Pt Wakefield Rd, Parafield Gardens SA.
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UniCredit S.p.A.
News about UniCredit S.p.A., including commentary and archival articles published in The New York Times.
Austrian Banks That Profited in Eastern Europe Now Share Region's Problems
Bad loans Austrian banks made to Eastern Europe are rising, albeit at a more moderate pace than a few months ago, and profits are down.
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Expect this situation to continue. The main determinant of energy use in the world is economic growth, and East Asia, which has accounted for two-thirds of all growth since 1990, is currently stalled. Cheap oil means cheap energy. Oil, and gas (which follows the oil price pretty closely) account for roughly two-thirds of the world's energy supplies, and coal makes up most of the rest. Only 10 per cent of the world's energy comes from non-fossil fuels, mostly nuclear and hydro-electric power. In many ways we should welcome a plentiful supply of cheap energy; it is a crucial element in determining living standards everywhere.
But in terms of the effect on the environment, this is very bad news. We cannot rely on the price mechanism to control our energy use. The market, when it is on your side, is a wonderfully powerful ally. Anyone who can remember the two oil shocks will recall how people cut energy use. The immediate effect was for people to drive less and turn down the thermostats, but there was also a longer-term effect, as car manufacturers focused on fuel consumption, and architects on the energy efficiency of buildings. From now on, though, the market will be against savings of this sort.
We can already see how hard it is to fight the market. The well-meaning legislation in the US to increase fuel efficiency has mainly had the effect of producing gutless cars, which in turn has encouraged real Americans to buy light trucks and four-wheel-drive vehicles instead. Of course, these use much more fuel, but fuel is so cheap that no one cares too much.
We should not, however, sneer at US hypocrisy. Our own deputy prime minister has recently publicised the fact that he is exchanging his regular official Jaguar for a new one fuelled by natural gas. But that does not make his Jag significantly kinder to the environment, or any more efficient. Gas is cheaper only because the tax is lower, and the global resources of gas are almost as tight as those for oil: around 52 years' supply compared with about 45 years'. (In fact, since up to one-third of the energy a car uses in its lifetime is used to manufacture it, the true environmentalist would try to use an old car, not a new one.)
So what will happen? We have the prospect of another generation of cheap energy, with all the inevitable environmental problems that will result. The only things that might change that - such as a real war in the Middle East - are too horrible to contemplate. Is there no way out?
Mercifully, there is a way forward. The solution comes in two parts. The first is to apply the market mechanism through taxation. Countries need to tax energy a lot more. Governments are already desperate for revenue, for they can see that their traditional sources are going to be relentlessly cut away. Companies are already able to shift their operations around the world to minimise their tax payments and extract the maximum in incentives to invest. Increasingly, rich individuals are doing the same. The more the tax burden is shifted to employers, the more they export the jobs.
The more it is put on consumption taxes such as VAT, the more the black economy grows; in Italy it is now about a quarter of the economy.
Energy taxation, by contrast, is remarkably difficult to evade. Fuel for vehicles is tightly controlled. So, too, is electricity and gas. There may be powerful political reasons for not wanting to increase energy taxation, but attitudes there can be changed - there used, after all, to be a strong political lobby against taxing tobacco more heavily - provided people feel that the extra revenues will not disappear into the usual black hole and be wasted. If environmental taxes were not used to spend more, but specifically targeted to reduce taxation elsewhere, then they might even become the one form of additional taxation that was positively popular.
However, while there are some things that can be done to conserve energy within national boundaries, others - such as taxation of aviation fuel - need international co-operation. That leads to the second part of the solution: we need to create a culture of conservation.
One of the difficulties politicians face is taking into account the interests of future generations, both people too young to vote now and (still more difficult) the unborn. These voices are unheard at election time. Yet individually we do care about posterity. We plant gardens and trees that won't reach full maturity in our lifetimes; we seek to leave something for our children; we support charities that try to protect endangered species.
Somehow politicians need to connect the interests of future generations to those of their present electorates. One way of making this connection real is to focus on the needs of the environment, and in particular the duties of each generation to treat it in a responsible way. We can all envisage a world 25 or 30 years hence when even more acres of beautiful countryside are covered with concrete, when our air is even dirtier than it is now, and when there have been long-term changes to our weather as a result of a build-up of greenhouse gases. Governments can use this aspect of public concern about the future to draw people's attention to something they find much harder to accept: that governments now should be running budget surpluses, paying off debt as fast as they can, and encouraging people to save for their own pensions so that the next generation of people of working age will not have to pay even more to support the growing army of the retired.
So the prospect of a generation of cheap energy is in one sense a threat. Miss the chance to be wise about energy use now, and we end up with a nastier environment a generation hence. But because everyone can see that, it is also an opportunity. It is an opportunity for those with influence - not just politicians but opinion-formers in general - to show that we can connect the interests of one generation with those of the next.
We do that by accepting that the benefit of cheaper oil should be passed to society as a whole, in the form of higher energy taxes.
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Piney Point Real Estate
Piney Point is located in Maryland. Piney Point, Maryland 20674 has a population of 644. Piney Point 20674 is less family-centric than the surrounding county with 23.83% of the households containing married families with children. The county average for households married with children is 37.93%.
The median household income in Piney Point, Maryland 20674 is $84,924. The median household income for the surrounding county is $85,032 compared to the national median of $53,046. The median age of people living in Piney Point 20674 is 57.3 years.
Piney Point Weather
The average high temperature in July is 87.4 degrees, with an average low temperature in January of 26.4 degrees. The average rainfall is approximately 44.1 inches per year, with 14.4 inches of snow per year. No weather information available.
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Beach Café
The Beach Café at Beach Road, Wells-next-the-Sea is in an idyllic location backed by mature pinewoods and a stone's throw from the beach. It's a fun and vibrant place to eat and drink and the perfect venue and place to meet.
As summer arrives, whether dining al fresco on the sunny terrace or picnicking on the beach, you can enjoy fresh local produce at its best, with tasty snacks and light meals, a variety of hot and cold drinks and everyone's favourite - ice creams and ice lollies. Children will love our 'Children's Meal Deal' and can choose five of our 'Beach Bites' and get a FREE bucket to carry them in! The café also offers a selection of tempting traditional beach goods.
In the winter months after a bracing walk on the beach, warm up by the roaring wood-burning stove. We've got traditional board games such as draughts, chess and Scrabble to keep you occupied and free WiFi if you need it. You'll love our range of knitted hats, gloves and scarves, ideal to keep you cosy. Or if you are feeling peckish then try one of our freshly baked cheese or fruit scones or our chilli with tortilla and soured cream. Our bacon baps are just the job too!
Calling All Dog Lovers
Your four-legged friends are also well catered for and welcome inside the café. We are proud to announce that for the second year running, the Beach Café has been voted the winner of the best Café/Restaurant category in the Kennel Club's Be Dog Friendly Awards 2015. The awards recognise businesses and places to visit that go that extra mile for our canine comrades and are based solely on public votes. Thank you to everyone that voted for us.
Why not enter your canine companion into our 'Dog of the Year' competition on the café's Facebook page. It's easy - Just post a photo of your dog enjoying the Beach Café for a chance to be crowned our 2016 winner! Click here for details. Or enrol Fido or Fifi into our popular 'K-9 Club' to receive our latest news and gossip by email. Just fill in a form during your visit to us.
Our self-service 'Wash 'n' Wag' dog wash is fun and free! After a run on the beach or swim in the sea, the fun and effective dog wash is a chance to wash down your pet in a specially enclosed booth, removing the sand and seawater from their coats. They can then dry off in the sun while you enjoy your refreshments with the knowledge that your pet will be clean and happy for the journey home.
What's On at the Café
We have various events and activities planned throughout the summer months and the café is a great place to stop off for a cuppa or snack!
Walking Women – Further information can be viewed here.
Please be aware that the café will be closed, due to essential water works by Anglian Water, on Monday 20th February until 12.30pm. We apologise for any inconvenience.
|Opening Times:
|1st January–31st March
|Open every day 10am–4pm
|1st April–30th June
|Open every day 10am–5pm
|1st July–4th September
|Open every day 9am–7pm
|5th September–31st October
|Open every day 10am–5pm
|1st November–31st December
|Open every day 10am–4pm (*Closed on Xmas day)
Beach Café, Beach Road, Wells-next-the-Sea, Norfolk, NR23 1DR.
Tel: 01328 713055 Email: firstname.lastname@example.com