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Making sense of the rewrite mess. Display and play with your rewrite rules.
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Save bandwidth by easily blocking links to video, audio, and other files from unapproved 3rd-party sites. Requires mod_rewrite.
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text:
In Stock
Expected to ship by .
Rollover to zoom
Click to enlarge
To view an item in an alternate color, place your mouse over a swatch above.
To view item in an alternate color, click on a swatch above.
Item #: 0536-17072-1102
This pretty mule with flower embroidery on the vamp is the perfect combination of style and comfort!
Women's mules available in full and half sizes 7-11, 12 M; 7-11, 12 W; 7-11, 12 WW
(based on 62 reviews)
of respondents would recommend this to a friend.
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
Best Uses
Feels full size too small
Feels half size too small
Feels true to size
79% (38 reviews)
(38 reviews)
Feels half size too big
Feels full size too big
Feels too narrow
Feels true to width
76% (38 reviews)
Feels too wide
Reviewed by 62 customers
Displaying reviews 1-30
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Previous | Next »
Great Buy
By SherryR
from Texas
Comments about Comfortview Bella Mule:
Very comfortable
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
Comforterview Desi Flat
By Comfee
from Dallas
Comfortview Desi Flat
You shipped the wrong size.
By Mo
from Panama City, Florida
About Me Conservative
Great shoe - I already own 2 in a 9 1/2 WW in beige and white.
(1 of 1 customers found this review helpful)
Nice and comfortable.
By Kathy
from Fort Collins, CO
About Me Stylish
Nice and comfortable mules. Quiet step.
By Lymphadema Lady
from Seattle, WA
I really want and need shoes I can slip into quickly and thought these would work. I bought two pairs in WW and can't get my feet all the way in. I'm hoping to get them stretched at the shoe repair. Based on how they fit I wish they came in a WWW
Bottom Line No, I would not recommend this to a friend
Cute and comfortable shoe
By KCNana
from Boise, Idaho
Nice shoe to slip into when in a hurry
Easy wearing shoe
By Nana
Great shoe and the reason I make stability a problem is not due to the shoe. It is because I must use a walker and my legs lengths are different so I have a pronounced limp. Otherwise the shoe is wonderful.
cute and easy
By mary
from pittsburgh, pa
I ordered an 8 1/2 because an 8 was unavailable. a little big but still a cute shoe.
(2 of 2 customers found this review helpful)
Very good shoe
By Marilyn
from Charing, GA
I bought this shoe to wear to Church with casual dresses. I also wear them everywhere else I go because they fit well, are easy to get on and off, and they match any other color. I don't like that they sound like flip flops when I walk but you have to take the bad with the good. Anyone who likes other clogs or mules will like this shoe but I didn't buy a plus size shoe, just an 8 Med.
Easy Walkers
By Steph
from Maryland
This shoe is comfortable. I love wearing them with jeans. Get a lot of compliments on these shoes as well.
love them
By miss bargin
from talihina okla
About Me Trendy
color is very good matches with outfits
I would by thuis again
By CeCe
from Hot Springs Arkansas
very comfortable shoe
Comfy foot cuddlers
By Deen
from West Virginia
Very comfortable and gives support for my foot unlike some other low heel mules.
love these shoes
By steph
from indpls,in
very comfortable
"I would buy this product again and again"
By reggie
from chicago
I found the shoe to be stylish and comfortable
Bella Mule CV Flex
By Mama
from Buffalo N.Y
It a very comfortable shoe.Great for a day of shopping or road trip.It's one of first shoe I enjoy wearing all the time.What I don't like is when I have to wait for my shoe to come. Weeks after I order them.
love wearing mules because of comfort
By retired
from Ohio
I enjoy wearing mules because it is like you are wearing a sandle without toes out. great for so many places to wear.
Not a good Fit
By Suridi
from New Stanton, PA
The mules feel too small. I feel like they are going to fall off my feet.
great purchase
By Bobcat
from Jackson, MS
Will be worn shopping and to work
not comfortable
By red
from durham nc
just not comfortable at all
Picture perfect mule
By Jen the shopper
from New Jersey
I ordered another shoe same size and they are a much better fit.
Love these CV Flex "Bella" Mules!
By Sandy in Florida
from Rockledge, FL
I do...I love my "Bella" mules. These are so comfortable! And stylish! My new go-to's for everything from jeans to dresses to even leggings! They're chic and sophisticated, yet downtown enough to wear to the club! They just go with everything! Dress them up, dress them down...you'll love wearing these uber-comfi mules everywhere! Enjoy!...and thanks Women Within!
Comfortable & fits well
By Sweet066
from Fayetteville, GA
Have worn with slacks & jeans. Comfy, nice looking & fit perfectly. Please with my purchase! :)
If there were more colors, I would buy all of them.
By Patricia
from Columbus, Ohio
As a teacher I am on my feet all day so I need shoes that I do not have to think about. These shoes are very comfortable. I have wide feet and these are just perfect. (Being mules though, they are hard to walk backward down the hall in :-)).
Uncomfortable fit
By Sheri
from Myrtle Creek, Or.
They looked nice but fit was not there.
Not what it seems
By Comfortable shoe lover
from Chicago/Miasissippi
Nice casual shoe
womens plus size bella mule
By ms.c
from New Orleans,La
wear them for church, for going out
Excellent shoe
By Sandy the shoe lover
from Baltimore, Md
I have worn this shoe with jeans,with a skirt and on a weekend trip. I truly love the comfort of the shoe.
I Love the Shoe and would definitely buy them again
By Pat
from Alexandria Virginia
Good for Casual Wear
By Pamela
from Sioux Falls, SD
Detailing does not appear to be "cheap" looking, size 8W feels true to size.

subset: commoncrawl


text:
You missed it This great deal for Suncoast Wellness is over. But don't despair, we've got more great deals every day.
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PAID VALUE EXPIRES ON February 23, 2022
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text:
2004 Infiniti FX35 Repair and Maintenance Costs
A guide to repairs, service, and maintenance costs for your 2004 Infiniti FX35
Never overpay. Check prices with our estimator
Verified by mechanics, reported by drivers like you
Ask a mechanic in our community
Our experts translate recalls into plain English
2004 Infiniti FX35 ProblemsFront wheel bearing causes grinding noise
Owners have reported a number of prematurely worn front wheel bearings. As the bearing fails, a rotational humming or grinding noise may be noted from the front as vehicle speed increases. Replacement of the bearing would be necessary to remedy this condition.
Popped open hood to find coolant sprayed all over the top of the engine. Hoses appeared intact. Coolant reservoir was empty. Radiator cap looked fine.
Diagnosed problem by bringing the engine to operating temperature and watching the coolant spray out of the radiator.
Issue was the radiator was cracked along the top (where it is plastic). Replaced the radiator.
2004 Infiniti FX35 Questionswhile driving my infinity my steering wheel locked hard to drive (1 answer)
what do you think is wrong my car never made noise or showed me signs that anything was wrong now its hard to drive due to it being hard to turn its like its stuck or locked.
Car has 128k miles. In pretty good shape and I'm pretty sure the dealer is going to charge an arm and a leg for this to be done.
Horn? Fan?
2004 Infiniti FX35 RecallsFront Airbag Inflator Module
This limited regional recall is for vehicles currently registered or first sold in southern Florida, along the Gulf Coast, Puerto Rico, Hawaii, the U.S. Virgin Islands, Guam, Saipan and American Samoa. Upon deployment the passenger airbag inflator could rupture, increasing the risk of personal injury. Dealers will replace the passenger side air bag inflator to correct this concern.
This limited regional recall is for vehicles currently registered or first sold in Florida, Puerto Rico, Hawaii and the U.S. Virgin Islands, and equipped with Takata-brand air bag inflators. Upon deployment the driver and/or passenger airbag inflator could rupture, increasing the risk of personal injury. Honda dealers will replace the affected airbag inflator modules to correct this concern.
It was found in compliance testing that some rear combination lamp assemblies did not meet illumination standards. This is against the Federal Motor Vehicles Safety Standard. Dealers will replace the rear combination lamp assemblies. The recall began December 18, 2006. The Infiniti recall number is R0607.


text: Betsy Kenney is an actor, writer and frighteningly beautiful woman living in New York City. She has been studying at UCB since 2011 and is a member of the UCB Harold team, Mermaids, and co-hosts a variety show with her great friend of the show, Matt Radlow in Matt & Betsy Do Music. Betsy is a co-creator of the HIT '90s series, The Place We Live, which can be seen at www.theplacewelive.us. Betsy has appeared in commercials, TV shows and articles all over the internet! More information on Betsy can be found on her very own, personal, expensive looking website- www.betsykenney.com


text:
Epic dude!
Serious brilliant mate!
This would be a pretty awesome thing to see
Coool! :-D
This will suit you quite well.
I'm not sure whether I'll be going to LFCC on Sunday but if I did maybe as Kestrel/John Wraith.
I'm actually going as Frank West on the Sunday at LFCC!
woop woop is all I have to say to this


text:
Buttonhole eyelet hole piece device (B-6TA) for that.
Dimensions below the eyelet hole piece is set
1. 6 cm-1. 8 cm-2. 1 cm-2. 4 cm
Type of stone
* Stone size 26 * 19. 5 mm
Size of pieces sewed on Botan horror
Dimensions inside (the size of the button).
Buttonhole or other related parts of the system provides to the address below.
This product cannot be shipped to United States from the store.
Please contact the store for further information.


text:
These are Dusty Pockets' latest 2 posts in our forums.
Dusty Pockets 5 months ago on 09/13/16
Things now are quite a bite more stable so that's nice. Also, I'm a lot more mature and aware of how to not be a jackass.
I'm still a pervert though. My first post back here was a joke about drunken makeouts.
This is a reply to the thread "Post on OB" by Lord_BullGod, posted in Gen. Chat
Dusty Pockets 5 months ago on 09/13/16
You are A++ in my book. Would drunk makeout with again.
This is a reply to the thread "I can't believe I'm making this post." by Quul, posted in Gen. Chat
Geek dating and social networking for awesome people.
OtakuBooty is where smart, funny, sexy nerds meet. Creating an account is free. Full membership is $4/month or $15/year. Cheap!
Press People. Need material? Cover OB for your site, blog, podcast, magazine, or what-have-you. More info »
Want Your Stuff Reviewed By OB? Just send us your press releases and requests to review your products.


text:
The military will have to undergo "draconian changes to force structure and modernization" as a result of sequestration, says Christine Fox, director of the Pentagon's primary cost analysis group, because the Pentagon can't squeeze enough reductions out of base closings and efficiencies alone. Under the cuts, "[w]e'd have to do terrible things to modernization," she says, a process that would affect upgrades of weapons programs.
Full Story:Bloomberg Businessweek


text:
Provides strong support for injured ankles
Provides strong support for injured knees
Supports injured knees
Firm support for injured wrists
Supports injured ankles firmly
Repel mosquitos and ticks
Relieves muscle pain with soothing heat
Special shapes protect wounds on your hand.
Fix bandages and dressings
The original plaster known for decades.
Help to prevent infection with antiseptic silver and a fabric plaster.
Protect fingers securely with an extra-long plaster.
Special shapes designed specifically for your hand.
On the go travel pack
Protect your wound with a plaster that adapts to all of your movements.
The first flexible plaster that doesn't get soaked.
Help wounds heal faster and reduce the risk of scaring.
Scrapes, cuts and grazes will be forgotten in a flurry of snowflakes with these cool plasters featuring their favourite characters.
Cover wounds discreetly with an invisible plaster.
Protect your child's wounds with favorite characters!
Stylish, durable box containing 16 mixed plasters.
Accelerate the healing process and help prevent scarring.
Reduce the visibility of scars
Fix bandages and dressings on sensitive skin
Sensitively protect small wounds.
Sensitively accelerate the healing process and help prevent scarring.
For medium to large wounds. Suitable after minor surgery.
Help to prevent infection with an XXL sensitive plaster
Cool and protect minor burns with a burn plaster.
Cover wounds quickly and easily with a spray on plaster.
Help to prevent infection with antiseptic silver and a water repellant plaster.
Protects small wounds with a water repellant plaster.
Prevent infection with a spray


text:
Society History By Time Period Nineteenth Century Wars and Conflicts Mexican-American War
This category lists sites concerning the 19th century Mexican-American War.
Subcategories 3
Related categories 4
Sites 28
1846: Portrait of a Nation
Smithsonian online exhibition of the political, cultural, and social character of America in 1846. In addition to the War, it looks at communications, transportation, manufacturing, social reform, science and pseudoscience, art, and literature.
Aztec Club of 1847
Military Society of the Mexican War. Includes history of the war and the 150 year old society, biographies, historical accounts, documents, photographs, artwork and links.
Bent's Old Fort National Historic Site
Located near La Juncta, CO. During the war with Mexico in 1846, the fort became a staging area for Colonel Stephen Watts Kearny's "Army of the West". Park information and links.
The California Bear Flag Revolt - 1846
Eyewitness account by John Bidwell of Fremont in the conquest of California.
Campaign in New Mexico with Colonel Doniphan
Text written in 1847 by Frank S. Edwards, a volunteer. Includes 7 chapters of details of military campaigns, with an Appendix.
Fort Scott National Historic Site
Kansas. National Park Service site about Fort established in 1842 and garrisoned by dragoon and infantry soldiers that played a major role in the Mexican War.
Handbook of Texas Online: MEXICAN WAR
A brief description of the major events of the war.
The History Guy: The Mexican-American War
A listing of the main facts about the war, plus a brief description of the causes and the conflict. It also contains unique facts and links.
Indiana Mexican War Soldiers
Detailed roster by regiment and company of Indiana soldiers who served in the Mexican War.
Merchant Marine in the Mexican-American War
A brief description of the Merchant Marine's in the Mexican-American War
Mexican American War - Liberty - Themepark
From the Utah Education Network, a brief description of the war with links to places, people, and related sites.
The Mexican War
From Texas Trail, an article that describes the background, campaigns, and impact of the war.
Mexican War
Historical school text from "American History" (1911) by David Muzzey, discussing the War.
Mexican War
Comprehensive site by Prof. De la Cova that includes maps, artwork, articles, and many links.
The Mexican War and U.S. Expansion to the Pacific
Politics in Mexico, republic of Texas and annexation, war, protests, California and the rest of northern Mexico. The invasion at Veracruz and fall of Mexico City, and the treaty of Guadalupe Hidalgo.
Mexican War History/Mexican War Re-Enactors
An information site that has articles on battles, dragoons, the military, the times, artillery, a bulletin board, photographs and reenactor information.
The Mexican-American War
Extensive free resources for the student of the War. Features detailed accounts of the battles, and biographies and pictures of the key leaders.
Mexican-American War and the Media
Links to transcriptions of newspaper articles and images related to the war from Virginia Tech. The transcriptions may be downloaded and used for teaching and research.
Michigan Military History: War with Mexico
History of Michigan's troops and their service during the war.
Ohio History Central - The Mexican War
Description of the War and Ohio's role in it.
Pictorial Americana: War with Mexico (Prints and Photographs Reading Room, Library of Congress)
Selected images from the Library of Congress relating to the War with Mexico (1846-1848); one chapter from a 1955 publication of the Prints and Photographs Division, Pictorial Americana.
The Political Graveyard: Politicians Killed in the Mexican War
A database of political history and cemeteries, with brief biographical entries for U.S. political figures who died in the War between 1846-1847.
Resaca de la Palma Site State Park
Texas. Brief description and location of this battlefield park.
Treaty of Guadalupe Hidalgo
Contains the text of the Treaty and related primary source materials from the online collections of the Library of Congress.
Treaty of Guadalupe Hidalgo
From the Avalon Project, the complete text of the treaty that ended the Mexican-American war.
The U.S. -Mexican War, 1846-1848
From the Descendants of the Mexican War, contains history, images, maps, historic sites, reading list, chronology, and statistics.
The U.S.-Mexican War (1846-1848)
An online companion resource to the PBS documentary. Text in English and Spanish. Contains dialogues, timeline, discussions, and resources.
US-Mexican War
US political context and overview of military campaign that ended with the Treaty of Guadalupe Hidalgo, 1816-1848. Provides links to US military sources.
Last update:July 20, 2016 at 14:45:05 UTC
All Languages


text:
If you are looking for cars that are less than 2000 dollars, check out some of the car listings below to find the car that best suits your budget. $2000 is a very low price for any car. You will need to choose carefully and read more tips before you bid.
Every car is different and there are many different choices out there if you take the time to look; below is a list of great used cars that you can find for under $2,000 and will still give you some good years of operation, as long as you follow the tips above before buying.
Best used cars for under $2,000 dollars
- Honda Accord (late 90s)
- Ford Ranger (2000-ish)
- Subaru Impreza (2000-02)
- Hyundai Accent (2000-ish)
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- Toyota Celica (90-92)
- Ford Taurus (94-99)
After you complete a purchase, please come back here and leave your testimonials. We greatly appreciate your valuable feedback.
Cheap Used Cars For Sale Under $2000
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text:
The Horse Forum (http://www.horseforum.com/forumindex.php)
- Horse Training (/horse-training/)
- - Halter Class (http://www.horseforum.com/horse-training/halter-class-33428/)
Halter Class
I'm going to this draft horse show on Wednesday and I've decided to enter a halter class. Does anybody have any suggestions/tips for making him trot in hand? I've tried to make him do it and he only trots sometimes.
You can start by working in hand with a dressage whip. When you ask your horse to trot, start off by you "bouncing" a little as you start trotting. Your bouncier gait is the cue that the horse will eventually work off of. You may need to exaggerate a bit at first, but soon your horse will snap into the trot with one "bouncy step" from you.
If bouncy steps don't encourage him into a pretty transition within a reasonable number of strides (say, 3 strides), tap his hip with the dressage whip. Usually a tickle does it. Be sure to always start with bouncy steps/verbal "trot" before tapping, that way you can wean him off of the whip. I don't show a ton of halter, and what I do show is tiny local shows, but I don't see whips in the ring. However, I have watched draft halter classes and read training books where the use of a stick or whip in the class seems okay, as long as it is aiding in showing the horse to the best advantage.
Good luck!
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text:
Go Knoebels
Knoebels Amusement Resort, located in Elysburg, PA, is the perfect family destination, offering FREE ADMISSION, FREE PARKING, and FREE ENTERTAINMENT. Go Knoebels serves as your mobile electronic guide to all the Fun, Food, and Fantasy that Knoebels has to offer. Find all the information you need about our wide variety of exciting rides, attractions…
Free • 310


text:
Well, Honfest is this weekend, and lucky for you we finally updated the Hampden Merchants website. Check out the actually searchable list of businesses in the Greater Hampden Area! The diversity in this neighborhood never ceases to amaze me.
So come check out the neighborhood, while drinking in the streets.
Curbside Cafe will be parked right outside our door Sat & Sun!
ETA: Sorry, Curbside Cafe is not going to be there on Sunday!


text:
Florida A&M hazing death claims President James Ammons
- 12 July 2012
- From the section US & Canada
The president of a Florida university where a student band member died in a hazing incident has resigned.
James Ammons had already received a vote of no-confidence from trustees of Florida A&M University for his response to the death of Robert Champion.
Champion died, allegedly beaten, after the university marching band performed at a football game in November.
Mr Ammons' resignation came on the same day Champion's parents launched legal action against the university.
There was no indication whether his resignation was linked to the legal action.
Robert and Pamela Champion launched their lawsuit alleging that not enough had been done to enforce anti-hazing policies or keep tabs on activities of members of the famed Florida Agricultural and Mechanical University marching band, the Marching 100.
Officials "failed to properly supervise, train, discipline and control the FAMU Band", the lawsuit said, according to the Associated Press.
The Champions described the resignation of James Ammons as part of necessary "housekeeping" at the university.
Mr Ammons had remained defiant over his position, saying recently that he would stay in his post until "the final bell rings".
Hazing involves subjecting members of a group or fraternity to humiliation or abuse, often as part of an initiation.
Mr Champion was a drum major and member of the Florida Agricultural and Mechanical University's legendary marching band, the Marching 100.
He was bruised on his upper body, bleeding internally and went into shock, medical officials said.
Eleven band members face charges over the hazing and have pleaded not guilty.
Their trial is scheduled to begin in October, the same month Mr Ammons' resignation comes into effect.


text: Hello fellow fish people, My name is Netty, and I am writing you today (Jan, 9th, 2012) to see if anyone has any opinions on how to help me with my sick fish. About 2 weeks ago, I cleaned my fish's tank. I am very particular about my fish. Most of them I have won at carnivals, but the ones that are sick were ones I bought from a pet store. They are all over 2 years old. I have a big black Moor and a medium sized calico moor, along with two black mollies. They have always been healthy, and I did not do ANYTHING DIFFERENT, or out of the ordinary when I cleaned their tank. The day after I cleaned their tank, I added a small pleco, then the day after that the pleco was dead. Then the following day my moors were sinking to the bottom of the tank and were hiding under/in their tunnel. Finally, on the third day of them acting like this, I noticed that my large black moor had ick. I assumed that it was introduced by the pleco however, I have another tank and I also bought a pleco for that tank and put it in that tank on the same day as the other (now dead) pleco was introduced to the other tank.... and he/she and the rest of the fish in the other tank are doing fine. What I have come to as a conclusion for the sickness of my moors and mollies is that I must have stressed them out while performing their tank cleaning. Anyway, once I gave them the ick meds, they seemed to come back to life, and have lost their ick spots. However, the large black moor still has some (I'm guessing) scars left from the ick. It looks as though he has white scars on the end of his tail that look like ick, but more like weakened parts of his tail that now have holes or perforations in it. After I got rid of the ick, the black moor then developed some fungus on his head, and the other calico moor now has some red marks on/under it's skin that look like (not raised) blood blisters. I have done EVERYTHING I CAN THINK OF to help these fish. I have sterilized their tank and all the stuff in it... I even bought new gravel. I have added ick meds, fungus meds, parasite meds, all in one meds, melafix, check the ammonia and nitrate level and have treated accordingly. I've also treated with quick cure, start right slime coat additives, I've used clear water , water conditioning, and have used Nutrafin Cycle Biological Aquarium supplement.... and I have been doing (every 3 to 4 day 25% water changes - using treated water that I let sit with the cap off for 3 plus days. I have also raised the salt content of the water (using aquarium salt) from 1 rounded tbl.spn per 5 gallons - up to - 2 rounded tbl.spn per 5 gallons..... PLUS, I have also raised the temp in the tank to the top of the "certified okay green zone" on the thermometer stick from where it had been (which was right in the middle of the "normal -or- okay" green zone section ...... I have cut back on their food, and have added some cooked peas to help with constipation. I have even gone as far as physically picking my black moor up, and gently wiping the fungus with Povidone-lodine wipes. And almost immediately after doing this, the fungus seemed to go away, but left a "red" mark in it's place..... The red mark was either from the color of the iodine or from the underlying wound (or raw spot) that had previously laid under the fungus. It didn't seem to go away once re-entering the water..... so that lead me to believe the red mark was not the color of the iodine, but a red raw spot on the moors head that was there before I started the gentle wiping and was just uncovered by the removal of the fungus. Now......After all that......and after adding the second dose of the fungus treatment........ My black moor has seemed to develop MORE FUNGUS, AND IT IS SPREADING FROM HIS HEAD, DOWN THE TOP OF HIS BODY????????????????????? Obviously my fish are VERY STRONG, AND HAVE A WILL TO LIVE THAT FAR EXCEEDS MOST HUMANS..... but I am very worried that I may lose them. I know that they are only fish, but I have raised them from "minnow size" to now being over 3 inches (for the mollies) and 5 inches (for the moors) and they have now become pets that I care about as much as I would a dog. I am at the end of my rope........ I am not even sure that I have listed all that I have done to be perfectly honest. PLEASE........IF YOU HAVE ANY ADVICE, PLEASE TELL ME A.S.A.P. Thank-you for your time. -Netty- P.S. ---- I also removed the carbon from the filter while I was using these treatments, but I had to add it back yesterday just due to the water quality and my own personal paranoia of there being chlorine and/or hard metals......... I also went out and bought both tanks new (and much better) heaters and thermometers just out of fear that the temp could have been the culprit ........ I am totally at a lose, and at the end of my rope..... PLEASE HELP ME IF YOU CAN!!!!!!!! IT IS NOW 12:09 PM ON THURSDAY JAN. 9th, 2012...... If possible, please email me back TODAY with some helpful answers.... I don't know how much longer my fish can last?!


text:
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Restaurants in Albuquerque, Santa Fe and Northern New Mexico, searchable by cuisine and location, with ratings and reviews. Get educated before you eat!
NEWSLETTERS Great Alibi stories, events and deals delivered to your inbox each week. No fooling!
Today's Events
Inaugural D.H. Lawrence Lecture at UNM Continuing Education Building
Award-winning author Mark Doty reads and discusses his work.
Why Humans and Apes are Different and Why It Matters at Maxwell Museum of Anthropology
Dillon PC • lo-fi pop • TrunkWeed • Holy Glories • garage rock, psychedelic • Crime Lab • punk • Euth Group at LaunchpadMore Recommended Events ››
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Malcolm Roth, M.D., FACS, on Brand Name Surgery Dangers
Even what sounds like a slam-dunk, easy procedure requires extensive training. You want to make sure that the individual doing the procedure is trained in all types of surgeries and non-invasive procedures and that they have all the safety measures, such as an accredited facility – and a transfer arrangement so that a patient can be transferred rapidly to a hospital if necessary.
And physicians should have privileges to do this type of procedure in a hospital where there is peer review. If they are only doing this in their office – and that is the only place they can do it -- and if they don't have privileges at a hospital - where patient safety is a primary concern -- then you probably don't want them doing it on you.
Featured Specialities:
Featured Doctors:
Optimal Wellness Network
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text:
As the stars explode,
Wither to dust..
They say a new one is born.
Through years, possibly a millennia,
It takes for a new one to for to form
It's only a matter of time before history meets it's end...
But love itself is timeless,
It grows without an end
You can supply it in multitudes
You give some here a little there.
Give it a number,
I say it amounts to more than every person breathes in air.
This love we've grown so find of,
We'd never comprehend.
Know that each time I say I love you,
My love shall never end.
© Copyright 2017 KATRA NIGHT. All rights reserved.
Status: Finished
Genre: Poetry
very sweet warm TRULY SPECIAL, Great stuff!
Beautiful :D
Book / Romance
Poem / Poetry
Poem / Poetry
Paste the link to picture in the entry below:
Paste the link to Youtube video in the following entry:
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text:
Tropical Fish Keeping - Aquarium fish care and resources (http://www.tropicalfishkeeping.com/forum.php)
- Vivariums and Reptiles (http://www.tropicalfishkeeping.com/vivariums-reptiles/)
- - Viquarium Tetra fauna! :D (http://www.tropicalfishkeeping.com/vivariums-reptiles/viquarium-tetra-fauna-d-89378/)
Viquarium Tetra fauna! :D
If you have not heard about this device, it is a Waterfall/filter decoration, and I think it is super cool!!,it splits the tank into halves between water and land. And it is very cool looking!! But that is where my problem comes in! I have bought one set up a tank but I'm stuck as to what could possibly fit in it :$!!!!!! ????? Like I was thinking a turtle but it occupies to much land! I'm just stumped -_-
Can anyone give me an idea? Thanks!!!!
Btw tank is About 30 gallons.. So ya :p
You could go with frogs or newts. I had a 55gallon setup once similar to what your talking about with both fire belly frogs and fire belly newts. The frogs loved the land and water part.
Their old model was better. They don't make it anymore. I got mine around 1997 or so, even then it was something like $60-80. I still have it, will probably set it up again one day when the little one wants to. Here are a few pics, more pics can be found here.
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A wall I have built for protection,
My heart now hidden from any affection.
A wall to protect againts lies,
Protection againts any painful surprise.
A wall built to repel love itself,
A wall made to protect me from myself.
The wall stands strong and high,
Built to avoid the pain of a good-bye.
A wall built throughout the years,
Built with pain, sorrow and tears.
A wall made to protect my hear from pain,
Made to ignore my heart and listen to my brain.
© Copyright 2017 Mezquiteno. All rights reserved.
Status: Finished
Genre: Poetry
Book / Poetry
Short Story / Other
Short Story / Other
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text:
Mori Lee by Madeline Gardner bridesmaids dresses Whether you want the bridesmaids dresses to be sophisticated and formal or floaty and feminine you will find a suitable item in this collection. Long bridesmaids dresses are a wonderful way to allow your bridesmaids to feel special and identify them as more than a guest at your wedding.
Mori Lee bridesmaids dresses are all available on a faster delivery for a small charge. If your wedding is less than 5 months away please do email or call us to check if you should pay the additional charge in order for your dresses to arrive with plenty of time.


text:
Policy.xml and AnyFind.zip update notifications
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Topic Search Topic Options
Joined: 24 Nov 2010
Location: Penn State
Status: Offline
Points: 31
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Posted: 07 Nov 2011 at 3:40pm
Much like how we can subscribe to the forum update on console and client updates, it would be great if there was a way to know when updated versions of policy.xml and AnyFind.zip were available. This way we would be emailed when those are changed/updated.
It would also be nice if the webpage containing AnyFind.zip contained the date of the latest definitions, or at the very least the version somewhere on the page, so that I know whether the ones I distribute via our console are the most current.
Product Management
Admin Group
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Points: 332
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Hello -
1) Policy Definitions are only updated when there are new settings implemented in the client and those settings are always reflected in the release notes. We recommend that any time you perform client updates that include new settings, you take the latest policy definitions. You can update the definitions from within the console on the resources page.
2) To solve the issue of ensure that the definitions that you push out are the latest, would it suffice to add to the same console resources page a display of the latest definitions and an option to download them?
Joined: 24 Nov 2010
Location: Penn State
Status: Offline
Points: 31
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Hello and thank you for your reply!
We do not allow our server to talk to Idf.com. Our console is only routable within the organizations IP space. We have our default policy configured to allow AnyFind updates to hit Idf.com, but have disabled Application Updates aside from allowing updates from our own console once we have tested each new version.
No one minds having users install the AnyFind definitions as they come out, but when a scheduled scan kicks off and there are new AnyFind defs, the scheduled scan does not check for and install updates before scanning.
Do you better understand why being notified of new definitions, or at least being able to manually check and verify at a glance on http://www.identityfinder.com/us/Company/AnyFind/ would be helpful for us? Whether it be the date released or the version number (41, 42, etc) on the webpage, anything would be nice. Just a suggestion, and thanks for your time.
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In Hollywood, close-ups are reserved for actors with either striking good looks or rectangular heads with a 1.85:1 aspect ratio. Boost your screen worthiness with this Groupon.
C$164 for Semipermanent Eyebrows ($399 Value)
During an initial consultation, a makeup artist evaluates your brows and desired outcome. Then, the technician applies a numbing agent to brows and begins to create individual ink strokes that simulate strands of hair. Upon completion, the technician provides in-depth aftercare instructions. Although the ink is imbedded in the skin, it does fade over time. Typically, patients return for a touch-up within four to six years.
Iris Beauty Solution
The skilled technicians at Iris Beauty Solution perform services that address skin concerns ranging from dry skin to unwanted hairs. Each beauty-enhancing regimen begins with a consultation, where clients receive in-depth service descriptions and a chance to ask questions about string theory before signing the consent form. To expedite service, Iris Beauty Solution posts open appointment slots through its online booking portal.
Customer Reviews
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Rising Stars Preschool
Enrollment for the 2016-2017 School year Starts March 1, don't delay!
Have a great summer
Staff will be back in the classroom
in August!
Thank You to all of our parents and staff for supporting our progarm could not have done it with out you!
2016-2017 School Year
Tuesdays and Thursdays (2 Days a week class)
9:00 Am to Noon, 3 & 4 year old class
$125.00 per month / $50.00 registration fee & $62.50 "June Deposit"
Mondays, Wednesdays, Fridays (3 Days a week class)
9:00 Am to Noon, 4 year old class
$175.00 per month / $50.00 registration fee & $87.50 "June Deposit"
Board meeting August 12th 5:30 pm
First day of school MWF September 7th
First day of school T/Th September 8th
Scholarship avaible for 2016 -2017 school year - see scholarship tab for more information
Thank You to Mid State Electric coop for supporting our program with a grant of $500.00! This will go towards our scholarship fund!
Thank You to Sunriver Rotary Club for your generous grant of 2000.00 for scholarships and supplies!
Thank You Sunriver Womens Club for your grant of 1500.00 for our scholarshiop program.
We are an equal opportunity provider and employer
Contact Us Today! 541-536-8362
We are located at 51605 Coach Rd.
in the La Pine Community Campus Building.


text:
In a message dated 12/20/2002 11:43:48 AM Central Standard Time,
firstname.lastname@example.com writes:
> You have to replant your catnip every
> year?
Although that's probably what I said, it's not what I meant. (That happens
more and more lately.) I have ever replanted it. The cats just roll around
on it all year -- even in winter when it's just nubs. Before I enter my
dotage I am going to master the art of using a digital camera! I promise to
bore everybody senseless with pictures of my babies when I have learned to
use one.
To sign-off this list, send email to email@example.com with the
message text UNSUBSCRIBE GARDENCHAT


text:
A debate over the merits of a campaign finance overhaul devolved into a spat between Senate Democrats and a top elections official.Read More »
To sue or not to sue over Clean Elections rule?
Secretary of State Michele Reagan is unlikely to sue over a new political committee rule passed by the Citizens Clean Elections Commission, but a top aide said he expects someone from the business community to go to court.Read More »
Reagan names top staffers for Secretary of State's Office
Michele Reagan announced who will serve as the top staffers in her administration at the Secretary of State's Office.Read More »
Reagan: Bring it on
The Democratic Party today said it plans on recalling four moderate Republican senators if they vote to remove any of the commissioners. The four senators told our reporter this afternoon they weren't concerned.Read More »


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Obituary & Guest Book Preview for Susan Garvey
Susan Garvey Obituary
First 25 of 380 words
: Susan Garvey NORFOLK, VA - After repeatedly defying death for decades, leading many to believe she was immortal, Susan Garvey, 56, died February 23 in...
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Susan Garvey Guest Book | View 2 of 2 Entries:
"Thank you for allowing us the opportunity to have this wonderful woman to give guidance and instuction to those of us in the field of Social work. We are very more informed after listening to her..." -
jeanise ratcliff
"I remember Susan from Cathedral High School. She was a good friend of my son Stephen Rivers and they had a wonderful group of friends who worked hard for the United Farm Workers. She was always in..." -
Ellen Rivers
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This page requires a MaxPreps membership account.
Don't stress... It's free and easy to setup.
The Hale Ray Noises volleyball team won Monday's home conference match against Old Lyme by a score of 3-0.
The Hale Ray Noises volleyball team scored 3 points and limited the visiting Old Lyme Wildcats to 0 in the Noises league victory on Monday.
The Noises now have a 3-0 record. They put it on the line next when they travel to Morgan for a Shoreline game on Wednesday, September 23. Hale Ray will meet a Huskies team coming off a 3-0 league win over Valley Regional (Deep River, CT). The Huskies record now stands at 3-0.
The Wildcats (0-3) will now prepare for their game against Haddam-Killingworth (Higganum, CT). The Cougars enter the Shoreline game with a 2-1 record. In their last game, Haddam-Killingworth gained a win over North Branford (North Branford, CT), 3-1, in a league game.
The Old Lyme Wildcats volleyball team lost Monday's away conference match against Hale Ray by a score of 3-0.
The Hale Ray Noises volleyball team won Friday's away conference match against Old Lyme by a score of 3-0.


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Circus Circuit Challenge Testimonials
Our first ever Circus Circuit Challenge is winding down this week, and our students are singing the praises of this tri-weekly intensive circus fitness class!
"What I loved most about the Circus Circuit is that I have become stronger faster than I ever thought I would- I've made so much progress so quickly! And it burns in all the right places." -Cy
"The Circus Circuit Challenge is great! It is a great price and it is nice to have a set workout time in place. Thanks to this series class I can execute a pullover on the trapeze without using the ropes, hold a plank for longer than I thought possible, and so much more. I have definitely gotten stronger/more toned in just 3 1/2 weeks. This class has been extremely valuable to my aerial practice and I plan to take this series again." -Heidi
"Circus Circuit Challenge has been an amazing month of workouts. I already do a lot of different physical activities, but Colleen has found ways to bring new, tough (but achievable) challenges to every class. We have fun, laugh, and work really hard. During this class I have accomplished several things I never thought I could do, including climbing a silk (UNASSISTED!) and a (very, very tiny) pullup from pike on the trapeze. The only bad thing about the class is that it has to come to an end! Boo!" -Eve
"After taking the Circus Circuit Challenge, I spend more time than is really necessary admiring my new muscles. Colleen manages to encourage and drive her students without being pushy or overbearing. This class has produced such good results for me that I'm planning on taking it again!" -Alison
Our next Circus Circuit Challenge starts the week of July 14th- sign up here!


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Sony Vpcca4e1e Driver Download
Sony Vpcca4e1e Driver Details:
Sony Vpcca4e1e File Name: sony_vpcca4e1e.zip
Sony Vpcca4e1e Driver Version: 70pP199
Sony Vpcca4e1e ZIP Size: 132.kb
Manufacturer: Sony
Scan Status: OK
Sony Vpcca4e1e special revision for: Windows Vista Ultimate 64 bit, Windows 7 Professional 64 bit, Windows XP Starter Edition 64 bit, Windows XP Media Center Edition 2004 32 bit, Windows 7 Enterprise (Microsoft Windows NT) 64 bit, Windows 10 32 bit, Windows XP Media Center Edition 64 bit, Windows XP Tablet PC Edition 32 bit, Windows XP 64-bit Edition 32 bit, Windows XP Home Edition, for home desktops and laptops 32 bit, Windows XP Professional N 32 bit, Windows Vista Business 32 bit
Sony Vpcca4e1e Download Stats:
Direct Downloads: 4928
Most Recent Download: 2/18/2017
Managed Downloads: 1652
Most Recent Download: 2/19/2017
Download Mirrors: 2
Current Delay: 30 Seconds
Driver License: GNU
Direct Download Success Stats:
Reports Issued By 3983/4928 Users
Success Reported By 401/3983 Users
Driver Download Score72/100
Driver Installation Score64/100
Overall preformance Score63/100
Installation Manager Success Stats:
Reports Issued By 1505/1652 Users
Success Reported By 1428/1505 Users
Driver Download Score84/100
Driver Installation Score84/100
Overall preformance Score94/100
1. Direct DownloadSelect your OS and press "Download".
This option requires basic OS understanding.
Select Your Operating System, download zipped files, and then proceed to
manually install them.
Recommended if Sony Vpcca4e1e is the only driver on your PC you wish to update.
2. Driver Installation Manager
This option requires no OS understanding.
Automatically scans your PC for the specific required version of Sony Vpcca4e1e + all other outdated drivers, and installs them all at once.
After downloading and installing Sony Vpcca4e1e, or the driver installation manager, take a few minutes to send us a report:
* Only registered users can upload a report.
Don't have a password?
Please register, and get one.


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All Topics
Biotech Business
Biotech Products
Drug Discovery
Infectious Diseases
Mental Health
Public Health
Track topics on Twitter Track topics that are important to you
It is well known that fish have stronger tolerance than mammals to microcystin (MC) exposure, and such a difference is attributed to their different core body temperatures. However, no in vivo study has been conducted to investigate the effects of temperature on MC-induced toxicity in fish, a typical poikilotherm. Tolerance and detoxification response of zebrafish treated with MC-LR were investigated under three temperatures. The LD(50) values evidently increased with a decline of the temperature (547, 260 and 176 µg kg(-1) at 12, 22 and 32 °C, respectively), indicating stronger tolerance of the fish at lower temperatures. Changes in the transcription of glutathione S-transferase (GST) isoforms in the fish were observed, and their sensitivity of response in the transcription of GST mRNA was on the order of 12 > 32 > 22°C. We screened out several GST genes which were more delicate to solve the MC-LR exposure at different temperatures, i.e. GST rho1, al, p1 and theta1 in the 12 °C group, and GST zeta1 and p2 in the 22 and 32 °C groups. Our findings partly validate the hypothesis that high temperature enhances toxic effects of MCs on poikilotherms. Our studies also indicate that temperature-dependent toxic effects should be taken into account for field toxic assessment of microcystins in fish. Copyright © 2010 John Wiley & Sons, Ltd.
Fisheries College of Huazhong Agricultural University; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Wuhan 430070, People's Republic of China.
This article was published in the following journal.
Name: Journal of applied toxicology : JAT
Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response.
Recent studies have demonstrated that cyanobacteria-derived Microcystin-LR (MC-LR) can cause developmental toxicity and trigger apoptosis in zebrafish (Danio rerio) larvae, but the underlying mechanis...
Effect of tributyltin on antioxidant ability and immune responses of zebrafish (Danio rerio).
Tributyltin (TBT) is a toxic compound released into aquatic ecosystems through antifouling paints. This study was designed to examine the effects of TBT on antioxidant ability and immune responses of ...
Analysis of the Enantioselective Effects of PCB95 in Zebrafish (Danio rerio) Embryos through Targeted Metabolomics by UPLC-MS/MS.
As persistent organic pollutants, polychlorinated biphenyls (PCBs) accumulate in the bodies of animals and humans, resulting in toxic effects on the reproductive, immune, nervous, and endocrine system...
Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking.
Bisphenol A (BPA) acts as an endocrine-disrupting compound even at a low concentration. Degradation of BPA could lead to the formation of toxic products. In this study, we compare the toxicity of BPA ...
Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio).
Intensive growth of cyanobacteria in freshwater promoted by eutrophication can lead to release of toxic secondary metabolites that may harm aquatic organisms and humans. The serine protease inhibitor ...
Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate
RATIONALE: Chemoprotective drugs such as carboxypeptidase-G2 may protect normal cells from the toxic effects of chemotherapy. PURPOSE: Clinical trial to study the effectiveness of carboxy...
A Clinical Trial of Alternating and Intermittent Regimens of 2',3'-Dideoxycytidine and 3'-Azido-3'-Deoxythymidine in the Treatment of Patients With AIDS and Advanced ARC
To determine if alternating zidovudine (AZT) and zalcitabine (dideoxycytidine; ddC) (first one and then the other) or intermittent therapy (1 week of drug then 1 week off) will lessen the ...
Study of a Potential New Treatment for Patients With Toxic Epidermal Necrolysis (TEN)
To determine whether treatment of patients who have toxic epidermal necrolysis with a drug called remicaide increases the number of patients who are alive 30 days laters.
A Study of AS-101 in Patients With AIDS or AIDS Related Complex (ARC)
To determine the toxic effects of AS-101 at various doses in patients with AIDS or AIDS related complex. Also to determine the effect of various doses of AS-101 on immune functions and the...
A Three-Part Study Of GSK580416 In Healthy Subjects
Studies for GSK580416 have been completed in rats and dogs. The main toxic effects seen in animals affected the digestive system and blood cells. Study OPS106400 will be the first admini...
Zebrafish Proteins
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Epidemiologic Studies
Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.
Investigational New Drug Application
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
Follow-up Studies
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
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A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...
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Does Virtualization Really Matter?SP360: Service Provider
That was the question that an attendee at a recent conference sponsored by the Communications Technology Management, part of University of California's Marshall School of Business, asked me last week.Read More
Join Us at The Internet Of Things World Forum Panel With AT&T, Sprint, and VodafoneSP360: Service Provider
Mobile Making It Happen The Internet of Things (IoT) is opening up a world of real opportunities and rapidly transforming our communities, our cities and our daily lives. The secondRead More
We Won! LTE Asia Awards UpdateSP360: Service Provider
So great news! A couple hours ago, the LTE Asia Organizers tweeted: Congrats to our #LTEAsia award winners: Best LTE Core Network Product @Cisco Our Cisco ASR 5000 Series hasRead More
Off to the LTE Asia Awards: Singapore or BustSP360: Service Provider
Think about what is going on in the APJC Mobile Market for a minute: In Korea, mobile data traffic on 2G, 3G, and 4G networks increased approximately 70% between 3QRead More
Cisco's Visual Networking Index: Understanding the Evolution of Internet Users, Devices and ConnectionsSP360: Service Provider
Today's networks are an essential part of business, education, government, and home communications. Many residential, business, and mobile Internet Protocol (IP) networking trends are being driven largely by the combinationRead More
Paradigm Shift with Edge IntelligenceOpen at Cisco
In my Internet of Things keynote at LinuxCon 2014 in Chicago last week, I touched upon a new trend: the rise of a new kind of utility or service model, theRead More


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Rainier Hospitality, Services, listed under "Services" category, is located at 211 Dexter Ave N Seattle WA, 98109 and can be reached by 2064437662 phone number. Rainier Hospitality has currently 0 reviews.This business profile is not yet claimed, and if you are the owner, claim your business profile for free. If you are not the owner you can invite this business to join by email or by phone.Browse all Services in Seattle WA. Discover census data for Seattle, WA.
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Between 8th and 9th avenues and J Street downtown, there's an empty space on the bottom floor of the TR Produce Building.
Jason Kulpa, CEO of Underground Elephant, an enterprise software company that provides companies a platform to generate sales leads, wants to put his 85 employees — and many more he wants to hire — there, but the city won't let him. The issue: He doesn't sell food or beer.
He will need special permission, and that will take time.
Downtown boosters have been talking up the city's central core as a garden where tech companies should plant their seeds. But Underground Elephant's struggle to move into an attractive, funky space is one angle on a bigger problem with that dream: Downtown doesn't have the space or the old buildings that seem to have captured young entrepreneurs' imaginations.


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The characteristics and development of the Swiss franc repurchase agreement market
With the reinterpretation of repurchase agreements (repos) by the tax authority and the revision of the national bank law in 1997, allowing the Swiss national bank (SNB) to use repos as monetary policy instrument, the prerequisites for the development of a Swiss franc repo market were given. The development of the repo market in Switzerland only came up in 1999 with the provision of an integrated trading and settlement system provided by SegaInterSettle AG (SIS), Eurex and Swiss Interbank Clearing (SIC) in collaboration with the SNB. The following paper provides an overview of the basic characteristics and structure of the Swiss franc repo market as well as of the development it has undergone since 1999. It also discusses what motives and reasons the banks possess to actively participate in the Swiss franc repo market. Copyright Swiss Society for Financial Market Research 2007
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 21 (2007)
Issue (Month): 2 (June)
Pages: 241-261
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Bjørn-Roger Wilhelmsen & Andrea Zaghini, 2005.
"Monetary policy predictability in the euro area: An international comparison,"
Working Paper
2005/7, Norges Bank.
- Bjørn-Roger Wilhelmsen & Andrea Zaghini, 2011. "Monetary policy predictability in the euro area: an international comparison," Applied Economics, Taylor & Francis Journals, vol. 43(20), pages 2533-2544.
- Wilhelmsen, Bjørn-Roger & Zaghini, Andrea, 2005. "Monetary policy predictability in the euro area: an international comparison," Working Paper Series 0504, European Central Bank.
- Dieter Nautz & Jörg Oechssler, 2003.
"Overbidding in Fixed Rate Tenders - An Empirical Assessment of Alternative Explanations,"
Bonn Econ Discussion Papers
bgse10_2003, University of Bonn, Germany.
- Nautz, Dieter & Oechssler, Jorg, 2006. "Overbidding in fixed rate tenders--an empirical assessment of alternative explanations," European Economic Review, Elsevier, vol. 50(3), pages 631-646, April.
- Bindseil, Ulrich, 2002. "Equilibrium bidding in the Eurosystem's open market operations," Working Paper Series 0137, European Central Bank.
- Thomas J. Jordan & Peter Kugler, 2004. "Implementing Swiss Monetary Policy: Steering the 3M-Libor with Repo Transactions," Swiss Journal of Economics and Statistics (SJES), Swiss Society of Economics and Statistics (SSES), vol. 140(III), pages 381-393, September.
- Breitung, Jorg & Nautz, Dieter, 2001. "The empirical performance of the ECB's repo auctions: evidence from aggregated and individual bidding data," Journal of International Money and Finance, Elsevier, vol. 20(6), pages 839-856, November.
- Michael J. Fleming & Kenneth D. Garbade, 2004. "Repurchase agreements with negative interest rates," Current Issues in Economics and Finance, Federal Reserve Bank of New York, vol. 10(Apr).
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text:
A game invented on a hot summers day at my nans house.
it is fun for 2 people up to as any as you can fit on the field of play.
a nerf ball(like in the picture)
a playing area(like a field or a leisure centre)
some friends
disclaimer: i am not liable for any injuries you suffer whilst playing this game


text:
Excellent PHP programmers needed
- Status Closed
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Project Description
1. Are you a PHP programmer who has created medium and large websites using pure PHP (without using any specific platform) ?
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+ I have a constant stream of medium level and large programming projects need reliable PHP programmers
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+ Let me know if you an agency or a solo freelancer and how many hours you have per week
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text:
DNA-protein interactions in high definition
DOI: 10.1186/gb-2012-13-1-139
© BioMed Central Ltd. 2012
Received: 9 January 2012
Accepted: 24 January 2012
Published: 27 January 2012
An elegant, genome-wide approach to define the precise DNA sequences bound by transcription factors has been developed by Rhee and Pugh.
Cis-acting DNA sequence elements are crucial to the proper regulation of transcription. The identification and functional characterization of these elements, often DNA sequence motifs, has progressed unevenly. For example, although the yeast Gal4 motif is well characterized and widely used in transgenic applications, up to half of yeast transcription factors (TFs) have opaque target sequences. ChIP-exo, a new method developed by Rhee and Pugh [1], seeks to assay DNA-protein binding at high resolution in order to fill in the cis-regulatory motif blanks.
The elusive functional motifs
To identify motifs in an unbiased, high-throughput manner, experimentalists have used in vitro methods such as SELEX [2] and protein-binding microarrays [3]. Such studies have accumulated a large catalogue of position weight matrices for DNA-binding motifs that is available in databases, including JASPER and TRANSFAC.
Whereas well-described motifs in Escherichia coli comprise as many as 24 bp, motifs in Drosophila and other metazoans tend to be much shorter, often comprising just 6 or 8 bp [4]. When analyzed in the large genomes of eukaryotes, such short motifs are commonplace. Cells must employ mechanisms to highlight the functional motifs or mask the decoy motifs in vivo. One major mechanism, identified through DNase hypersensitivity experiments, is accessibility of motifs in open DNA regions [5]. These nucleosome-free regions are also flanked by distinct chromatin signatures. In any cell type, a small fraction of the genome, including promoters and enhancers, adopts such an open chromatin configuration. Thus, the majority of motifs are found in inaccessible regions with higher nucleosome occupancy and chromatin compaction. Notably, the combination of DNase hypersensitivity assays with high-throughput sequencing can enable high-resolution footprinting of bound sequence motifs, albeit without direct identification of the interacting DNA-binding protein [6, 7]. The DNase approach can be complemented by direct mapping of TF-binding sites through combination of chromatin immunoprecipitation with deep sequencing (ChIP-Seq).
Despite biochemical and molecular evidence linking TFs to specific motifs, a high proportion of binding sites returned in systematic TF-mapping studies have lacked the consensus motifs. Although the correspondence between binding and motif presence improved with the transition from array-based approaches to ChIP-seq, it remained that half or more of all detected sites could not be linked to a cognate motif [8]. Computational efforts to define alternative or degenerate motifs have been successful [9], but have been hindered by the modest resolution of ChIP-Seq. Additional filters, such as conservation across species, have helped narrow down the candidate regions, but can only infer the relevant TF or cell type. These analyses are likely to be limited by biological complexity, such as DNA methylation status of the motif, competitive or collaborative binding of multiple TFs, DNA looping, low occupancy sites, and stability or half-life of DNA-protein interactions. Taken together, these limitations point to a critical need for additional experimental methods capable of defining, at base pair resolution, protein-DNA interaction in vivo.
ChIP-exo improves resolution
Rhee and Pugh used ChIP-exo on four proteins in yeast and one protein in human cells. The single base pair resolution of ChIP-exo allowed for new insights into DNA-protein interactions. For example, they found yeast Reb1 is bound exactly 95 bp upstream of transcription start sites, and often coincides with a second Reb1 binding event of lower occupancy 40 bp away. As these two binding events are relatively close, they would be indistinguishable from a single binding event in ChIP-Seq. Additionally, the authors investigated the binding of Phd1, a transcriptional activator with an ambiguous motif. They found Phd1 binds two distinct motifs, and a third degenerate motif, possibly explaining its motif ambiguity. To the extent that ChIP-exo sequencing reads represent protein occupancy, all three motifs had the same occupancy of Phd1 binding, indicating protein binding is not always decreased at degenerate motifs.
Rhee and Pugh also investigated Rap1, a unique DNA binding protein that binds at both telomeres and ribosomal genes. The telomere-bound sites had a GT-rich 27 bp motif, while non-telomere binding had three versions of a 12 to 13 bp motif. The motifs had significant heterogeneity that the authors suggest is compensated for by the length of the motif. Interestingly, they note that Rap1 is bound to regions previously identified as containing nucleosomes. They propose that lambda exonuclease chews through DNA that is wrapped about histones, yet stops at the Rap1 DNA crosslink. The authors do not speculate on why the nucleosomal DNA is relatively more susceptible to exonuclease digestion, but nonetheless the TF-binding event is detected by ChIP-exo.
Modular motifs
Lastly, the authors used the new method to map CTCF in human HeLa cells. A minority of CTCF is bound at promoters; it is not a TF in the traditional sense, but likely plays more diverse roles in genome folding, insulation and boundary formation. It has been shown in vitro that CTCF utilizes combinations of its 11 zinc-finger domains to bind to different DNA sequences [10]. Using the new method, the authors identified six related motifs, composed of combinations of four modules. CTCF occupancy increased with the increasing number of modules present, and only half of CTCF binding occurred at the motif most similar to the canonical CTCF motif, which contains modules no. 2 and no. 3.
The data of Rhee and Pugh provide insights into TF binding at low occupancy sites, which they argue plays a biologically functional role, as opposed to random TF scanning or noisy binding events. They found that low TF occupancy correlates with either single nucleotide substitutions in the underlying motif (as seen with Reb1), or a decrease in the number of modules within a motif (as seen with CTCF). However, Rhee and Pugh note that low occupancy sites have similar characteristics to high occupancy sites, such as distance to transcription start sites. As ChIP-exo is done on additional TFs, particularly in mammalian models, it will be interesting to see if this holds as a common theme, or if more diverse binding modes will be found. Additionally, the current data do not address the mechanisms for low occupancy binding, such as a protein binding for shorter lengths of time due to reduced binding energy, competitive binding of other proteins, or rapid removal by transcriptional machinery.
In conclusion, ChIP-exo presents a valuable complement to ChIP-Seq, DNase footprinting and chromatin mapping in pursuit of a more precise understanding of the biochemical interactions that mediate context-specific genome function.
- bp:
base pair
transcription factor.
Authors' Affiliations
- Rhee HS, Pugh BF: Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Cell. 2011, 147: 1408-1419. 10.1016/j.cell.2011.11.013.PubMedPubMed CentralView ArticleGoogle Scholar
- Cui Y, Wang Q, Stormo GD, Calvo JM: A consensus sequence for binding of Lrp to DNA. J Bacteriol. 1995, 177: 4872-4880.PubMedPubMed CentralGoogle Scholar
- Bulyk ML, Gentalen E, Lockhart DJ, Church GM: Quantifying DNA-protein interactions by double-stranded DNA arrays. Nat Biotechnol. 1999, 17: 573-577. 10.1038/9878.PubMedView ArticleGoogle Scholar
- Bird A: The dinucleotide CG as a genomic signalling module. J Mol Biol. 2011, 409: 47-53. 10.1016/j.jmb.2011.01.056.PubMedView ArticleGoogle Scholar
- Weintraub H, Groudine M: Chromosomal subunits in active genes have an altered conformation. Science. 1976, 193: 848-856. 10.1126/science.948749.PubMedView ArticleGoogle Scholar
- Hesselberth JR, Chen X, Zhang Z, Sabo PJ, Sandstrom R, Reynolds AP, Thurman RE, Neph S, Kuehn MS, Noble WS, Fields S, Stamatoyannopoulos JA: Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods. 2009, 6: 283-289. 10.1038/nmeth.1313.PubMedPubMed CentralView ArticleGoogle Scholar
- Boyle AP, Song L, Lee BK, London D, Keefe D, Birney E, Iyer VR, Crawford GE, Furey TS: High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. Genome Res. 2011, 21: 456-464. 10.1101/gr.112656.110.PubMedPubMed CentralView ArticleGoogle Scholar
- Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED: Comparative epigenomic analysis of murine and human adipogenesis. Cell. 2010, 143: 156-169. 10.1016/j.cell.2010.09.006.PubMedPubMed CentralView ArticleGoogle Scholar
- Ji H, Jiang H, Ma W, Johnson DS, Myers RM, Wong WH: An integrated software system for analyzing ChIP-chip and ChIP-seq data. Nat Biotechnol. 2008, 26: 1293-1300. 10.1038/nbt.1505.PubMedPubMed CentralView ArticleGoogle Scholar
- Ohlsson R, Renkawitz R, Lobanenkov V: CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet. 2001, 17: 520-527. 10.1016/S0168-9525(01)02366-6.PubMedView ArticleGoogle Scholar


text:
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Looking for restaurants open for Easter?
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I'm working on this cover for a digital book of guidelines and best practices for making a tablet magazine...
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HEDUNNIT - The Life Insurance Scam
When she died
He confessed to it
A crime of passion
He admitted it
She never shut up
She screamed and bit
He wanted out
She never wanted it
His previous wife
The one he loved to bits
But because of drugs
They didn't make it
They devised this plan
To become her man
Insure her tits
The beneficiary
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They met secretly
In the room above
No one could tell
They put her through hell
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A crime of passion
Bought him three short years
The crime of passion
With crocodile tears
Out on parole
Who did he call?
The one of previous years
They shared the loot
The interest was good
They lived on high
The years passed them by
And the policy of
taking insurance for love
can make a grown man cry
Only three short years
And then they'd be together
The policy paid out well
They'd be happy forever
And while they live in dreams
Another schemer schemes
and so we watch the weather
© Copyright 2017 Raine Carosin. All rights reserved.
Status: Finished
Genre: Song Lyrics
Short Story / Humor
Short Story / Poetry
Short Story / Literary Fiction
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Go wild with these safari animal card shapes! Decorate using our acrylic paints then add wiggle-eyes, wool and stick-ons. Made from strong white card in 10 assorted shapes. Size 15cm-24cm.
Thank you for visiting Safari Animal Card Shapes - Pack of 10 on hundredsofgiftideas.co.uk
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The Role of Family Background on Secondary School Choices
The aim of our work is to measure the impact of social origins on the choice of the academic track in order to allow for consistent cross-country comparisons. We analyze Italy, the Netherlands, and Germany, employing the data from PISA 2003. A substantive problem is that a good measure of individual ability before tracking occurs is not available, thus ability cannot be adequately kept under control. A simple model for school choice is proposed, but the model is not identified with cross-section data. The consequences of unobserved ability are assessed; in the absence of a measure of ability at time the track, the logit regression coefficient of social background is an estimate of the total effect of social background, given by the sum of direct and indirect effects. This is a measure of substantive interest because it represents the total causal effect of social origins on school track. Yet, given that regression coefficients in logit models with independent unobserved heterogeneity are biased towards zero, comparison across countries are difficult; the average sample derivative of the response probability is employed, and it is shown to be a valid alternative measure of the effect of explanatory variables in this context. Our main substantive finding is that the total effect of social background on the choice of the academic track is weaker in the Netherlands and stronger in Germany, with Italy somewhere in between, although, as the German case reveals, when access is regulated by formal restrictions based on ability tests the role of parental background is significantly reduced.
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Write-in votes, in the 1985 Boise, Idaho, mayoral election, cast for Mr. Potato Head: 4
Ada County Elections Office (Boise, Idaho)
A Spanish design student created a speech-recognition pillow into which the restive confide their worries, which are then printed out in the morning.