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Life Extension Update
July 12, 2005
Life Extension Update Exclusive:
U.S. tops the world in health care spending
Featured Products:
Melatonin capsules
The Life Extension Revolution
Life Extension magazine July 2005 issue
Therapeutic options for fibromyalgia, by Sergey A. Dzugan, MD
A report published in the July/August 2005 issue of the journal Health Affairs (www.healthaffairs.org) revealed that Americans spend more on health care than any other country, with expenditures that are 140 percent above the $2,193 per capita spending of the median industrialized country.
Utilizing data provided by the Organization for Economic Cooperation and Development, researchers at Johns Hopkins University Bloomberg School of Public Health reviewed health care spending in 30 countries during the year 2002. They found that U.S. citizens spent an average of $5,267 per capita on health care, which is 53 percent higher than Switzerland, a country that had the second highest per capita health care expenditure of $3,446. Explanations that have been offered for the difference are the waiting lists for certain procedures in some countries and the cost of malpractice litigation in the United States, yet Dr Anderson and colleagues found that the former accounted for only 3 percent of the difference, and the latter was comparable to other major developed nations.
The authors suggest that defensive medicine may be part of the reason for the discrepancy, but conclude, "The two most important reasons for higher U.S. spending appear to be higher incomes and higher medical care prices."
Lead author Gerald Anderson PhD, who is a professor at Bloomberg School of Medicine's Department of Health Policy and Management commented, "As in previous years, it comes back to the fact that we are paying much higher prices for health care goods and services in the United States. Paying more is okay if our outcomes were better than other countries. But we are paying more for comparable outcomes."
Fibromyalgia is a condition characterized by severe muscle pain. The term fibromyalgia means pain in the muscles and fibrous connective tissues (tendons and ligaments). Fibromyalgia is associated with poor-quality sleep and is often accompanied by depression and anxiety. It is also referred to as a syndrome because fibromyalgia is a group of symptoms. It shares some of the features of chronic fatigue syndrome (CFS), with 70% of patients diagnosed with fibromyalgia also meeting the diagnostic criteria for CFS.
Fibromyalgia is associated with elevated levels of proinflammatory cytokines. At the annual meeting of the Endocrine Society in San Francisco (June 22, 2002), researchers reported that sleep deprivation markedly increases inflammatory cytokines (Vgontzas et al. 1999). This finding may help explain why pain flare-ups occur in response to lack of sleep in a variety of disorders, including fibromyalgia.
Melatonin is the most effective antioxidant yet studied because it easily penetrates cell membranes (especially in the brain) to provide protection against free radicals throughout all of our cells. Melatonin also crosses the blood-brain barrier very effectively. It appears to protect the central nervous system against injury, disease, and aging better than any other substance. Melatonin is used to induce drowsiness and improve sleep patterns and more physicians are recommending melatonin as a safe and effective insomnia therapy (Shochat et al. 1998). Melatonin not only helps most people sleep better, but it has been shown to alleviate pain (Jeong et al. 2000; Yu et al. 2000; Dauvilliers et al. 2001; Gagnier 2001; Pekarkova et al. 2001).
Featured Products
Melatonin keeps our circadian cycle in tune as it communicates with the body's cells. Not only does this hormone work to maintain cell health, it appears to regulate a system of self-repair and regeneration. When this hard-working hormone is diminished, our biological functions are impaired.
Many people use melatonin to help improve sleep. Some research has found that melatonin increases the speed of falling asleep and adds to the quality of sleep in about 60% of people who use it.
The Life Extension Revolution, by Philip Lee Miller MD and the Life Extension Foundation
In this new book, antiaging physician Philip Lee Miller, MD, teams with respected health author Monica Reinagel to offer a comprehensive guide to the "new science of growing older without aging."
With The Life Extension Revolution, Dr. Miller and his colleagues at the Life Extension Foundation hope to introduce the life extension philosophy and practice of optimal health and longevity to a new audience of millions around the world.
"Science has repeatedly ratified the many controversial positions [Life Extension] has advanced," notes Dr. Miller. "Over the years, the Foundation's careful, rigorous, and responsible approach has made it well regarded by even the most conventional of physicians."
Case history: Therapeutic options for fibromyalgia, by Sergey A. Dzugan, MD
While chronic, widespread musculoskeletal pain (fibromyalgia) has been recorded since antiquity, only in the past two decades have researchers conducted significant medical and experimental studies on the subject. According to recent findings, 1.3-4.8% of the populations of Western industrialized nations suffer from fibromyalgia, and 80-90% of those affected are women. Approximately 6 million Americans (including 4 million women) suffer from fibromyalgia, which most commonly occurs between the ages of 30 and 60 years.
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A resource for reliable information about significant people, places, events, and things in Minnesota history.
The Town and Country Club is founded in St. Paul. First located on the shores of Lake Como, in 1891 the club would move to its present location near the Marshall Avenue Bridge. A golf course, originally tomato cans sunk in a pasture, is set up in 1893, and it is now the second oldest course in the country.
The Duluth, Missabe and Northern Railroad is established by the Merritt brothers to carry iron ore from the Mesabi Range to Lake Superior ports. Leonidas Merritt had discovered iron near Mountain Iron the previous November.
Wanda Gag is born in New Ulm. An author and artist, she would write and illustrate the children's classic Millions of Cats .
After a sensational trial, Harry T. Hayward is hanged in the Minneapolis jail for the murder of Katherine Ging, owner of a fashionable dressmaking establishment. He had arranged for her to be killed so that he could collect her life insurance money.
A special train brings ten carloads of Minnesota Ojibwe to see the Buffalo Bill Wild West show in Ashland, Wisconsin, which in turn causes many whites to come see the Indians.
In an effort to control speeding bicyclists, the St. Paul police department establishes a squad of twelve bicycle officers to patrol the roads and sidewalks, keeping the public safe from "scorchers." The speed limits are set at six miles per hour on sidewalks and eight on streets.
All thirteen of the cars in Minneapolis race from the Hennepin County courthouse to Wayzata to demonstrate to the county commissioners the need for better roads. Harry Wilcox arrives in Wayzata first, making the twelve-mile run in forty-two minutes.
How strong was the Galveston, Texas, hurricane of 1900? The remnants of the storm drop 6.65 inches of rain on Minnesota from September 9 to 11.
The statue Mississippi, Father of Waters is unveiled in Minneapolis City Hall. An allegorical representation of the Mississippi River, the statue was carved from a single block of marble by Larkin Goldsmith Mead and weighs almost 14,000 pounds.
The St. Paul Institute of Science and Letters is incorporated, with Charles W. Ames as its first president. The institute's museum is first located in the Auditorium, then moved to the Merriam mansion on University Avenue, and now dwells in downtown St. Paul, known as the Science Museum of Minnesota.
Canada and the United States sign a treaty forming the International Joint Commission, a legislative body charged with preventing and settling disputes in the boundary waters region.
The American Legion, a veterans organization, holds its first convention, in Minneapolis. The convention begins on November 10 and ends on November 12.
The Armistice Day Blizzard strikes, trapping hunters at lakes and drivers on roads. Forty-nine people die when temperatures suddenly drop from the sixties to below zero. Pilot Max Conrad of Winona earns hero honors for taking his Piper Cub up into fifty-mile-per-hour winds to drop supplies and lead rescuers to trapped hunters.
Nellie Stone Johnson, union organizer and activist, is elected to the Minneapolis library board, the first African American ever elected to a citywide post in Minneapolis.
The state historical society recognizes ethnographer Frances Densmore for "distinguished service in the field of Minnesota History." Densmore, a Red Wing native, was one of the first ethnologists to specialize in the study of American Indian music and culture and is perhaps best known for her field recordings of Ojibwe songs.
The dwellings in Swede Hollow, a St. Paul immigrant neighborhood, are burned after the city health department declares them contaminated.
Norman E. Borlaug, University of Minnesota alumnus and crop researcher, receives the Nobel Peace Prize for his research in hybridizing wheat to increase crop yields. Borlaug is known as the father of the green revolution.
The first Minnesota Renaissance Festival opens at Lake Grace in Jonathan. One of the largest of its kind, the festival now operates from a permanent encampment near Shakopee.
The Mall of America opens to a gala ceremony, an unexpected parking crunch, and an estimated 150,000 shoppers, who, as the Star Tribune would comment, "took a vacation from recession and bought." Standing on what was the site of Metropolitan Stadium, the "megamall" is the largest in the United States.
Duluth's state representative Willard Munger dies. He had served over forty years in the Minnesota House and was known as an advocate for environmental protection.
St. Paul native Paul Molitor announces his retirement from baseball, having spent his final three seasons with the Minnesota Twins. His career hits numbered over 3,000, most of them from his years with the Milwaukee Brewers.
After sixteen month of often bitter protest, four oak trees sacred to the Mendota Mdewakanton Dakota Community are cut down to make way for the rerouting of Highway 55 in Minneapolis.
James Shields is born in Ireland. He would be a U.S. senator for three different states: Illinois, Minnesota, and Missouri. After moving to Faribault in 1855, he would be one of the first two senators selected by the state's legislature, and while in office he would encourage Irish immigration to Minnesota. Shieldsville in Rice County is named for him. He died in 1879.
Willis A. Gorman is born in Flemingsburg, Kentucky. He would be appointed second territorial governor of Minnesota in 1853 and would later serve in the legislature, command the First Minnesota Regiment in the Civil War, and be St. Paul's city attorney from 1869 until his death on May 20, 1876.
Lieutenant Colonel Zachary Taylor ends his command at Fort Snelling, which had begun May 24, 1828. He would later lead the U.S. Army in the war against Mexico, and "Old Rough and Ready" would take that fame to the White House. Taylor is the only U.S. president to have spent a significant amount of time in Minnesota.
Made possible by the Arts and Cultural Heritage Fund through the vote of Minnesotans on November 4, 2008. Administered by the Minnesota Historical Society.
Minnesota Historical Society • 345 W. Kellogg Blvd., St. Paul, MN 55102-1906 (Map) • 651-259-3000 © .
Send questions or comments to mnopediamnhs [dot] org. View our Privacy Policy.

subset: commoncrawl


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The current experiments on structural determination cannot keep up the pace with the steadily emerging RNA sequences and new functions. This underscores the urgent request for an accurate free energy model for RNA tertiary folds, from which one can predict structures from sequences. Furthermore, there is increasing support for the idea that large structured RNAs may adopt a variety of conformational states, rather than just one, during the course of performing its biological function, this is particularly so in the replication of RNA viruses and a central tenet of riboswitch-mediated regulation of gene expression in bacteria. Although considerable progress has been made in mechanistic studies, accurate prediction for RNA tertiary folding from sequence remains an unsolved problem. The first and most important requirement for understanding and predicting of RNA folding from RNA structural fluctuations to large conformational changes is an accurate free energy model. Support from this grant has allowed us to develop a novel virtual bond-based RNA free energy model that enables much better predictions than other existing models for simple tertiary structures (pseudoknots). We now propose to go beyond the simple pseudoknots by studying all-atom, larger, more complex RNA tertiary folds. Our approach will be based on rigorous, first principles analytical calculations. A key advantage of the approach is the completeness and certainty in conformational sampling (entropy). Incorrect entropy results in poor predictions. Preliminary tests using experimental data have shown significant improvements from our approach in both accuracy and specificity than existing folding algorithms. The success attests the high promise of the new approach proposed in this grant.
Our specific aims are: (a) Systematic model development for tertiary folding free energies. (b) Developing a novel approach for complex, larger tertiary folds. (c) Developing a 3D all-atom model. (d) Systematic test and refinement of the model using experimental structural data.
This project will develop a model for accurate predictions of all-atom structures and free energy landscapes for RNA tertiary folds. This predictive model will contribute to the quantitative understanding of RNA mechanisms in cellular functions as well as the rational design of RNA-based therapeutics.
|He, Zhaojian; Zhu, Yuhong; Chen, Shi-Jie (2014) Exploring the electrostatic energy landscape for tetraloop-receptor docking. Phys Chem Chem Phys 16:6367-75
|Xu, Xiaojun; Zhao, Peinan; Chen, Shi-Jie (2014) Vfold: a web server for RNA structure and folding thermodynamics prediction. PLoS One 9:e107504
|Zhu, Yuhong; Chen, Shi-Jie (2014) Many-body effect in ion binding to RNA. J Chem Phys 141:055101
|Cao, Song; Xu, Xiaojun; Chen, Shi-Jie (2014) Predicting structure and stability for RNA complexes with intermolecular loop-loop base-pairing. RNA 20:835-45
|He, Zhaojian; Chen, Shi-Jie (2013) Quantifying Coulombic and solvent polarization-mediated forces between DNA helices. J Phys Chem B 117:7221-7
|Cao, Song; Chen, Shi-Jie (2012) A domain-based model for predicting large and complex pseudoknotted structures. RNA Biol 9:200-11
|Cruz, Jose Almeida; Blanchet, Marc-Frederick; Boniecki, Michal et al. (2012) RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction. RNA 18:610-25
|Cao, Song; Chen, Shi-Jie (2012) Predicting kissing interactions in microRNA-target complex and assessment of microRNA activity. Nucleic Acids Res 40:4681-90
|Stammler, Suzanne N; Cao, Song; Chen, Shi-Jie et al. (2011) A conserved RNA pseudoknot in a putative molecular switch domain of the 3'-untranslated region of coronaviruses is only marginally stable. RNA 17:1747-59
|Rockey, William M; Hernandez, Frank J; Huang, Sheng-You et al. (2011) Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling. Nucleic Acid Ther 21:299-314
Showing the most recent 10 out of 42 publications


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Amy Robach was named News Anchor for ABC's "Good Morning America" in March 2014.
Since joining ABC News, Robach has traveled nationally and internationally to... Read More »
Amy Robach was named News Anchor for ABC's "Good Morning America" in March 2014.
Since joining ABC News, Robach has traveled nationally and internationally to cover major news events. She reported from Brussels on the terror attacks in 2016. She also traveled to Iceland to report on the front lines of climate change with the world's most elite ice climbers, taking viewers into an ice sinkhole over a hundred feet deep live using the latest in drone technology. As part of GMA's Hidden Worlds series, she reported from Tanzania on the poaching epidemic and its impact across the globe. In 2014, she traveled to Nigeria to interview Malala Yousafzai, the seventeen year-old who was in the African country as part of a campaign to free hundreds of captive school girls. She also reported live from South Africa just days after the shooting of Oscar Pistorious' girlfriend Reeva Steenkamp. Robach anchored ABC News' coverage of the 2014 Winter Olympics in Sochi, Russia and reported from London for the birth of Prince George. Breaking news stories in the U.S. Robach has covered include: Superstorm Sandy, reporting live from the Rockaways on the one-year anniversary, and the Sandy Hook Elementary School shooting in Newtown, Connecticut.
Additionally, Robach has interviewed countless newsmakers and celebrities. Her headline making interviews include: Hulk Hogan who responded to making racial slurs and Monica Lewinsky, her first network interview in over a decade. She also sat down with Real Housewives of New Jersey's Teresa Giudice after time spent in a federal prison and recording pop star Taylor Swift after her worldwide exclusive live-stream on Yahoo and ABC News announcing Swift's new album and single.
Robach has reported and hosted several "20/20" programs for ABC News. In 2012, she spent weeks in the Utah desert to take viewers inside the world of Polygamist leader Warren Jeffs and the FLDS for the prime time special, "Breaking Polygamy: Secrets of the Sect." In December 2013, Robach hosted the two-hour primetime special "Secrets of the Castle: Beyond Downton Abbey" where she traveled to the English and Scottish country sides to go behind the scenes of "Downton Abbey" and explore the present day British aristocracy. In 2014, she anchored a special "20/20: The Fast Times of Oscar Pistorius."
In 2015, Robach wrote a New York Times bestseller titled "Better: How I Let Go of Control, Held On To Hope, and Found Joy in My Darkest Hour" about her unexpected journey with breast cancer.
Before joining ABC News, Robach worked at NBC News from 2003 to 2012. In 2007, Robach was the co-anchor of Saturday TODAY and an NBC News National Correspondent. During that time, she also filled in as Weekday TODAY co-anchor, Weekday Newsreader and anchor for NBC Nightly News with Brian Williams. Prior to that, Robach was an anchor for MSNBC from 2003-2007.
During her 9 years at NBC, Robach interviewed major political newsmakers: Barack Obama in 2004, Senator John McCain, Speaker Nancy Pelosi, Speaker Newt Gingrich, as well as world leaders such as Prime Minister Benjamin Netanyahu. Robach also covered the 2004 and 2008 presidential elections, traveling to Iowa to interview the candidates. She also interviewed Elizabeth Edwards, following the scandal with her husband, John Edwards and Rielle Hunter. Robach traveled to Beijing to cover the 2008 Olympic Games. In 2009, she nabbed the first sit down interview with Illinois governor Rod Blagojevich as he faced impeachment and criminal charges. In 2010, Robach got a rare one-on-one interview with Britain's Prince Harry in Barbados. She flew in an F-18 fighter jet, broke the sound barrier, landed on and then catapulted off the aircraft carrier, the USS George HW Bush. Robach also traveled the globe, reporting for "Where in the World Is Matt Lauer" with live broadcasts from Kuala Lumpur, Malaysia and the Seychelles.
From 1999-2003, Robach worked at WTTG in Washington, DC as a reporter and morning and noon anchor. She covered the aftermath of 9/11 and the war with Iraq, reporting live from the Pentagon. Robach also contributed to the Edward R. Murrow award winning broadcast covering the Serial Sniper attacks and was honored in Regardie's magazine as one of the top 100 powerful Washingtonians.
Robach got her start as a general assignment reporter from 1995-1999 at WCBD TV in Charleston, SC. There, she traveled to Honduras to cover the aftermath of Hurricane Mitch and reported from Iceland to cover the transport of "Keiko," aka Free Willy, to his native waters via a Charleston Air Force C-17 cargo plane. Robach also spent many summers reporting live from hurricanes Bertha, Fran and Bonnie as they battered the North Carolina coast. As a crime reporter, Robach also witnessed the lethal injection of a man who had been sitting on death row for over 20 years, convicted of a triple homicide.
Robach is originally from Lansing, Michigan. She grew up in St. Louis, Missouri and then moved down south to Atlanta, GA just before high school. Robach attended the University of Georgia where she graduated with honors and a degree in Broadcast Journalism. She currently resides in New York City with her husband, two daughters and is also the stepmom to three wonderful boys.« Read Less


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GATE 2017 Exam date can be checked from the table given below. GATE 2017 application forms were released in first week of September 2016 and registration closed in first week of October 2016. We are providing you the GATE 2017 exam date for ECE, EEE, EE, CSE, Civil Engineering, Mechanical Engineering, Aerospace, Architecture, Instrumentation, Life Science and Engineering Science etc. GATE 2017 ... Read More »
Exam date
GATE 2016 Important dates- Check Here
GATE 2016 important dates are available now. You can check out GATE 2016 important dates from the official web portal of GATE exam and also from this page. So check out all important dates for GATE exam like starting date of application, last date of application, exam date, admit card release date, result date, score card release date. Every Engineer ... Read More »


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More Videos...
1971 Buick skylark custom **for sale 20k**
1971 Buick skylark custom,rebuilt 350 engine and transmission. New rims and tires 22x9.5.alpine in dash navagation and type x components and type r subwoofers custom trunk set up. Magna flow Exhaust.black cherry paint with black racing stripes. New custom interior with power seats. Located near San jose california. Asking 20k 4085902935.no trades please only cash
1972 Buick Skylark at the dragstrip
1972 Buick Skylark at Union Grove goes down the track but lets off 1/2 way down for engine temp shoot up
1971 Buick Skylark Custom Hardtop
1971 Buick Skylark Custom Hardtop
1968 Buick Skylark Drop Top on 24 inch Gold Daytons
Custom Brandy Wine Kandy 1968 Buick Skylark on 24 inch All Gold Daytons. Hosted By DJ Skript and Talia O Neal MUSIC FETTI RECORDS TRACK A.M.P. IM A G


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"Tempe's NEIGHBORHOOD GOLF COURSE, BAR & RESTAURANT"
Our spectacular Shalimar Country Club gives the golfer a feeling that is not found anywhere else near Tempe. We feature 9 holes of golf in Tempe that is ideal for all levels of golfers and is designed to help you improve your game. Our idyllic settings will let you step away from life for a little while and focus on your golf passion. Our professionally engineered course will challenge you to decrease your score on our fairways, various water hazards and tactically placed sand traps.
We also offer 18 holes of FootGolf and a popular Restaurant and Bar.
Sun up to Sun down
Bar Hours
(subject to change)
Kitchen Hours
Monday - Friday 10am - 8pm
Saturday and Sunday 8am to 6pm
Breakfast served 8am to noon Saturday and Sunday
(subject to change)


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Mr. Storch, age 59, has served as Chief Executive Officer of Hudson's Bay Company since January 2015, a leading owner and operator of department stores including Saks Fifth Avenue, Lord & Taylor, Hudson's Bay Department Stores, Home Outfitters, Saks OFF 5th, Kaufhof, Inno, and the e commerce business Gilt. From November 2013 to January 2014 he served as Chairman and Chief Executive Officer of Storch Advisors. He also served as Chairman of Toys"R"Us, Inc. from February 2006 to November 2013 and Chief Executive Officer of Toys"R"Us from February 2006 to May 2013. Prior to joining Toys"R"Us, Mr. Storch served as Vice Chairman of Target Corporation. He joined Target in 1993 as Senior Vice President of Strategy and served in roles of increasing seniority over the next 12 years. Prior to joining Target, Mr. Storch was a partner at McKinsey & Company. He is a director of Fanatics, Inc. Mr. Storch is a Director of Supervalu, Inc.
© 2017 Bristol-Myers Squibb Company Legal Notice » Privacy Policy » Trademarks


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Watching politicians writing security legislation is like watching dogs poop.FTFY
profitable enoughThere. Right there, Karl, is what you don't get. There is no such phrase in the religion of capitalism.
O'Rielly argues at great lengths that government should simply stay out of the affairs of the private sector...Hey O'Rielly, how about getting rid of these pseudo-monopolies and let the market REALLY sort out some issues? Let them compete on price and service? No? Then screw you, you lying hypocrite.


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Does this restaurant have parking?
Does this restaurant offer highchairs for toddlers?
Is this restaurant good for lunch?
Can a gluten free person get a good meal at this restaurant?
Is this primarily a coffee shop?
Are the prices at this restaurant low or inexpensive?
Can a vegetarian person get a good meal at this restaurant?
Can a vegan person get a good meal at this restaurant?
Does this restaurant specialize in Halal food?
Is this a Kosher restaurant?
Thanks for helping!
I visit kind coffee every year when I am in Estes. They have fantastic coffee and staff. My only complaint is the weird layout of the coffee shop. But they have amazing views behind the coffee shop. Grab a coffee and go out back and sit!
Stayed in Estes for 4 days and each day found something delicious to drink. Skip Starbucks try kind coffee & help out a local business!
While the atmosphere is fairly typical of small town coffee shops, the coffee falls short. As a roaster myself, I was expecting some high quality craft coffee brewed with care and intent. Instead, I received some burnt auto drip mass produced tasting coffee. It also felt like I did not belong because I was not a local. Most of the...
Delicious and very environmentally conscious coffee shop. The seating outside is peaceful beside a small creek running behind the place. (I visited October '14)
Delicious teas and coffees. The cheese/fruit plate was wonderful. The shop has views of the mountains with outdoor tables as well.
Came here on a busy early November weekend after having a lousy experience at Starbucks, which is just a short walk away. The difference was amazing! Starbucks: dark, somewhat messy, indifferent staff. Kind Coffee: bright, attentive and appropriately named. Both places were crowded, but we didn't feel neglected here like we did at SB. As a newbie, I was impressed...
Don't miss this place if you are a coffee lover--it is excellent. Try their autumn gold (seasonal) or avalanche coffee drinks--both suberb. Friendly, joyful staff made it even more pleasant, and if it's warm and sunny, sit outside along the river. Awesome find.
This quickly became our favorite breakfast spot. Everything we tried was delicious. The staff were super friendly and the coffee shop sits right beside the river, so you could enjoy breakfast while taking in the sites and sounds of the river.
Kind is the perfect name for this spot right on the riverwalk. The staff are smiling, patient and kind! My husband had to work remotely while we were on vacation and he found a nice little table, great wifi connection as the connection from our cabin was iffy. The coffe is excellent!
When looking back at my experience at Kind Coffee to write this review - I sat back in my chair, closed my eyes, smiled, and let out the most wonderful sigh. I could almost feel the coffee warming my bones again at their shop in downtown Estes Park, CO. The coffee is hot, the people are friendly, and the 4...
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


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The Tennessee Wildlife Resources Agency will host a public information meeting about the removal of the Browns Mill Dam from the East Fork of the Stones River in Rutherford County.
Anyone interested may visit the session from 6:30 to 8 p.m. Tuesday at the Lascassas Fire Hall at 6531 Lascassas Pike.
The wildlife agency will be on hand, along with staff from Griggs and Maloney Engineering & Environmental Consulting.


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: GIGABYTE Radeon HD 7790 GV-R779OC-2GD 2GB 128-Bit GDDR5 PCI Express 3.0 x16 HDCP Ready Video Card
Pros: Fast shipping
Cons: Would not work right out of the box. I took to it a few different computer stores and it would not work on any of their rigs.READ FULL REVIEW


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Carberry, who underwent an operation on his spleen after collapsing with abdominal pains, still finished second with 71 winners to Ruby Walsh in the Irish jockeys' championship.
"I feel grand and I'm really looking forward to coming back," Carberry said yesterday. "I'll just try and ride as many winners as possible, but I'll certainly have a crack at the championship."
The Northern Ireland Festival of Racing at Down Royal on 5 and 6 November continues to attract top performers and Paul Nicholls yesterday confirmed that Dines, one of last season's top novice chasers, will contest the Isuzu Chase over two miles and two furlongs, which is worth pounds 20,000 and is for second-season chasers.
"Dines will accompany See More Business and I could have other runners at the meeting," Nicholls said. See More Business. his Cheltenham Gold Cup winner, runs in the pounds 100,000 Jim Nicholson Ulster Champion Chase.Reuse content


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also which one fits my needs and other things. thanks again
also which one fits my needs and other things. thanks again
Visit my Blog at www.slipperytrail.net
Visit me on Facebook!
Visit my YouTube Channel
and finally
My twitter feed
I know I'll have at least 2 extra hammocks.
My ego said, SURE you can.
Half way in my body said OH NO YOU CAN'T
Growing old is mandatory, growing up is optional.
My YouTube
Any Turkey hunters coming?
So if you all would pray for rain, preferably in NOLA for that weekend it would free me up from 4 soccer games for my kids, make that happen and I can make the hang! Otherwise, I will try to get a little hang time in Lafrenierre park in Metairie. HELP, please make it rain....
Visit my Blog at www.slipperytrail.net
Visit me on Facebook!
Visit my YouTube Channel
and finally
My twitter feed
It's almost here! I'm chomping at the bit for this trip. I'm really looking forward to the hike in and meeting some other forum members (and seeing some others that I've already met!) C'mon mid Oct!
If you ain't havin' fun, you're doin' it wrong
Got to admit, I'm looking forward to it as well. Want to see everyone's gear and get a few pointers from more experienced hangers. Sounds like fun too...
I never hike alone. The voices in my head are always with me.
i have started packing and also will be bringing extra gear i would like to sale or trade i have alot of pocket knives and extra knives and 2 extra pot stands.
if anyone does not mind i need to get rid of extra stuff
again i have a bunch of pocket knifes for like $5 a peice
2 brand new alcohol stoves with some dry fuel and matches $10 obo
2 hobo tools (fork, spoon,knife, etc) $7 obo
i really have knives coming out of my ears..ouch
Bring cash..or trades..though im not really looking for anything in particular
though i can take credit via init payment system and cell phone pending how good the signal is..
I will have 3 hammocks if anyone wants to test one out
I think i will have 2 tarps, and may bring 2 sleeping bags though one is larger.
anyone know if dogs are allowed??
i have been thinking about maybe bringing mine..though i prob wont..
hang your own hang
Bayou Serenity


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XML Expert to create XML templates for my forms using Simple Groupware
- Status Closed
- Budget $8 - $25 USD / hour
- Total Bids 10
Project Description
I have attached a very detailed outline of the website that I had wanted. Having gone through several developers, and each of them miserably failing, I have decided to do the following: Use an existing framework and add on the forms in there.
This is Phase I of the development of our company portal (small company ~ 35 employees)
Phase II will include data mining and generating reports from the database and presenting it in a nice fashion.
For this phase, we are simply looking for an avid programmer that can take the example forms we have attached in excel format and most of the ones from the AB+[url removed, login to view] file [to-do list, messaging and e-mail are no longer required clearly], and create XML templates using the simple groupeware XML format.
[url removed, login to view]
[url removed, login to view]
For further details on SgsML
The first $100 milestone will be for creating one of our forms successfully in Simple Groupeware and we can proceed from there.
Please contact with any questions regarding the linked data etc.
Bonus points for being able to create forms that allow images to be uploaded in them, that would later be included in the reports that follow.Get free quotes for a project like this
Skills Required
Looking to make some money?
- Set your budget and the timeframe
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Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis
- Mercedes García-Bermúdez†1,
- Raquel López-Mejías†2,
- Fernanda Genre†2,
- Santos Castañeda3,
- Javier Llorca4,
- Carlos González-Juanatey5,
- Alfonso Corrales2,
- Begoña Ubilla2,
- José A Miranda-Filloy6,
- Trinitario Pina2,
- Carmen Gómez-Vaquero7,
- Luis Rodríguez-Rodríguez8,
- Benjamín Fernández-Gutiérrez8,
- Alejandro Balsa9,
- Dora Pascual-Salcedo9,
- Francisco J López-Longo10,
- Patricia Carreira11,
- Ricardo Blanco2,
- Javier Martín1 and
- Miguel A González-Gay2, 12Email author
DOI: 10.1186/ar4608
© García-Bermúdez et al.; licensee BioMed Central Ltd. 2014
Received: 11 March 2014
Accepted: 17 June 2014
Published: 10 July 2014
Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased cardiovascular (CV) disease risk. Interferon regulatory factor 5 (IRF5) is a regulator of type I interferon induction. Recently, researchers have described an association between multiple single-nucleotide polymorphisms of the IRF5 gene and some rheumatic disorders. In this study, we aimed to evaluate whether three different haplotype blocks within the IRF5 locus which have been shown to alter the protein function are involved in the risk of CV events occurring in Spanish RA patients.
Three IRF5 polymorphisms (rs2004640, rs2070197 and rs10954213) representative of each haplotype group were genotyped by performing TaqMan assays using a 7900HT Fast Real-Time PCR System with tissue from a total of 2,137 Spanish patients diagnosed with RA. Among them, 390 (18.2%) had experienced CV events. The relationship of IRF5 genotypes and haplotypes to CV events was tested using Cox regression.
Male sex, age at RA diagnosis and most traditional risk factors (hypertension, dyslipidemia and smoking habit) were associated with increased risk for CV events in the RA population. Interestingly, a protective effect of both IRF5 rs2004640 GG and IRF5 rs10954213 GG genotypes against the risk for CV events after adjusting the results for sex, age at RA diagnosis and traditional CV disease risk factors was observed (hazard ratio (HR) = 0.6, 95% confidence interval (CI) = 0.38 to 0.92, P = 0.02; and HR = 0.58, 95% CI = 0.36 to 0.95, P = 0.03, respectively). Moreover, we detected a protective effect of the GTG haplotype against the risk for CV events after adjusting the results for potential confounding factors (HR = 0.72, 95% CI = 0.56 to 0.93, P = 0.012).
Our results reveal that IRF5 gene variants are associated with risk of CV events in patients with RA.
Rheumatoid arthritis (RA) is a chronic inflammatory rheumatic disease associated with an increased risk for cardiovascular (CV) events and CV disease–related deaths compared to the general population [1]. Because of that, adequate stratification of CV disease risk has special relevance in RA patients. Researchers in several studies have demonstrated that RA is an independent risk factor for premature heart disease [2]. This process is the result of a combined effect of traditional CV disease risk factors [3], the magnitude and severity of a chronic inflammatory response [4] and genetic factors located inside [4] and outside the human leukocyte antigen (HLA) region [5–8].
Type I interferons (IFNs) are signaling molecules involved in both innate and adaptive immunity. Misregulated expression of type I IFN genes has been observed in peripheral white blood cells of patients with several autoimmune diseases [9]. In this regard, interferon regulatory factor 5 (IRF5) has been involved in the regulation of type I IFN gene transcription [10, 11]. This protein is critical for the production of proinflammatory cytokines [12], such as TNF-α, interleukin 12 (IL-12) and IL-6, following Toll-like receptor signaling. IRF5 also acts as a molecular switch that controls inflammatory mechanisms mediated by macrophage cells [12].
IRF5 protein is encoded by the IRF5 gene, which is located in chromosome 7q32.1. Several genetic studies have described the relevance of multiple single-nucleotide polymorphisms (SNPs) of the IRF5 gene in different rheumatic disorders, such as RA and lupus erythematosus [13, 14]. In this context, three groups of correlated IRF5 variants, designated as groups 1, 2 and 3, have been found to be independently associated with these inflammatory disorders and with different functional roles. Group 1 includes SNPs tagging a 30-bp in-frame insertion/deletion variant of exon 6 that alters protein stability. The association of group 2 SNPs seems to be explained by the T allele of IRF5 rs2004640 polymorphism that allows the expression of an alternative isoform and is associated with significantly higher levels of IRF5 expression. The association of group 3 SNPs is probably due to the rs10954213 A allele that creates an early polyadenylation site which leads to higher IRF5 expression [14].
Taking into account all of these considerations together in the present study, we analyzed the potential role of one tagging SNP of each group of independent signals (rs2004640, rs2070197 and rs10954213) in the risk for CV disease in a large and well-characterized cohort of patients with RA.
Patients and study protocol
A set of 2,137 Spanish patients with RA were included in the present study. Blood samples were obtained from patients recruited from University Hospital Lucus Augusti (Lugo), Marqués de Valdecilla University Hospital (Santander), Hospital de Bellvitge (Barcelona) Hospital Clínico San Carlos, La Paz University Hospital, Hospital de La Princesa, University Hospital Gregorio Marañón and 12 de Octubre University Hospital (Madrid). Informed written consent was obtained from all participants. The study was approved by the ethics committees of Galicia for University Hospital Lucus Augusti; of Cantabria for Marqués de Valdecilla University Hospital; of Cataluña for Hospital de Bellvitge; and of Madrid for Hospital Clínico San Carlos, La Paz University Hospital, Hospital de La Princesa, University Hospital Gregorio Marañón and 12 de Octubre University Hospital. All the patients fulfilled the RA classification criteria published by the American College of Rheumatology in 1987 and 2010 [15, 16]. In all the cases, patients were assessed for the IRF5 rs2004640, rs2070197 and rs10954213 polymorphisms.
Demographic and clinical characteristics a
Clinical features
% ( n/ N) or mean ± SD
Main characteristics
Age at disease onset (yr)
53 ± 14.8
Follow-up duration (yr)
12.5 ± 8.25
Females (%)
Rheumatoid factor–positiveb
68.3 (1,413/2,070)
Anti-CCP antibody–positive
57.3 (1,024/1,785)
Shared epitope–positive
62.6 (734/1,173)
54.4 (866/1,591)
Extraarticular manifestationsc
31.3 (481/1,537)
Cardiovascular risk factors
40.3 (846/2,100)
Diabetes mellitus
13.1 (275/2,100)
38.3 (805/2,100)
19.6 (413/2,100)
Smoking habit
27.4 (576/2,100)
Patients with cardiovascular events (total)
18.2 (390/2,137)
Ischemic heart disease
8.5 (181/2,137)
Heart failure
5.7 (122/2,137)
Cerebrovascular accident
5.6 (120/2,137)
Peripheral arteriopathy
2.8 (60/2,137)
Patient DNA was obtained from peripheral blood using standard methods. The IRF5 rs2004640, rs2070197 and rs10954213 polymorphisms were genotyped with predesigned TaqMan SNP genotyping assays in a 7900HT Fast Real-Time PCR System according to the conditions recommended by the manufacturer (Applied Biosystems, Foster City, CA, USA). Negative controls and duplicate samples were included to check the accuracy of genotyping.
Statistical analysis
The genotype data were checked for deviation from Hardy-Weinberg equilibrium (HWE) using a previously described method [18]. The relationship of genotypes, alleles and haplotypes to CV events that occurred in the follow-up was tested using Cox regression adjusted for sex, age at RA diagnosis and traditional CV disease risk factors. For that purpose, we used the most frequent genotype, allele and haplotype as reference variables. The end of follow-up was the first date of occurrence of the following: end of the study period, date of death or date of CV event. Follow-up time was estimated as the difference between the RA diagnosis date and the end of follow-up. Patients without CV events during the follow-up time and those who died by any non–CV-event–related cause were censored. The results are expressed as hazard ratios (HRs) with 95% confidence intervals (CIs). In order to have a reference population, 10,000 replications were generated by assigning CV events in randomized fashion to the actual studied population. The proportion of the risk for CV disease due to age at disease diagnosis, smoking history, hypertension and genetic variants at the IRF5 locus among the RA patients was estimated as the Nelson-Aalen cumulative HR. Comparative values between the different genetic models of inheritance for IRF5 polymorphisms were estimated using the Akaike Information Criterion (AIC). Statistical significance was defined as P ≤ 0.05, and all analyses were performed using Stata SE/12 statistical software (Stata Corp, College Station, TX, USA).
The IRF5 rs2004640, rs2070197 and rs10954213 polymorphism genotype distributions were in Hardy-Weinberg equilibrium. The genotyping success rate was greater than 98% in all cases. Genotype and allele frequencies of the IRF5 rs2004640, rs2070197 and rs10954213 polymorphisms were in agreement with the data in the HapMap database [19].
Factors associated with cardiovascular events in a series of 2,137 rheumatoid patients a
Males (reference: females)
1.42 (1.07 to 1.87)
Age at RA diagnosis (by each year)
1.07 (1.06 to 1.09)
1.40 (1.029 to 1.92)
Diabetes mellitus
1.18 (0.83 to 1.68)
0.93 (0.67 to 1.31)
1.42 (1.05 to 1.93)
1.58 (1.26 to 1.99)
1 (reference)
1.07 (0.79 to 1.45)
0.59 (0.38 to 0.92)
1 (reference)
1.16 (0.69 to 1.95)
1.32 (0.32 to 5.52)
1 (reference)
0.95 (0.71 to 1.26)
0.58 (0.36 to 0.95)
Results of haplotype analysis in rheumatoid arthritis patients with vs. without cardiovascular disease a
HR (95% CI)b
1 (reference)
0.72 (0.56 to 0.93)
0.85 (0.61 to 1.18)
1.14 (0.75 to 1.74)
Additional file 1: Table S1 describes the proportion of the CV disease risk disease for RA patients due to age at disease diagnosis, smoking history, hypertension and the genetic variants at the IRF5 locus. Additional file 2: Table S2 displays the genetic model of inheritance of our analysis. Interestingly, as shown in Additional file 1: Table S1, the presence of GG genotypes in the IRF5 rs2004640 and rs1095213 polymorphisms decreased CV disease risk in 0.7% and 1% of patients, respectively (Additional file 1: Table S1). In addition, smoking, age at disease diagnosis and presence of hypertension increased the risk of CV disease (Additional file 1: Table S1). Further, as shown in Additional file 2: Table S2, the AIC estimation for the recessive model showed the lower level in the IRF5 rs2004640 and rs1095213 polymorphisms, which made it the preferable model for our study (Additional file 2: Table S2).
CV disease is the most common cause of premature mortality in patients with RA [1, 2]. The augmented CV disease mortality observed in this pathology is the result of a compound effect mediated by traditional CV disease risk factors and chronic inflammation [3, 4]. Because genes have also been associated with an increased risk of CV disease in RA, research in the past several years has been focused on the search for genetic markers that may improve the identification of RA patients at risk of experiencing CV events [4–8].
Outside the HLA region, IFN pathway genes, which encode cytokines with critical modulatory effects on innate and adaptive immunity, have been shown to represent a key component of the genetic network leading to autoimmune processes. In this context, several polymorphisms in the IRF5 gene (a regulator of type I IFN induction) [10, 11] are associated with an increased risk of immune-mediated diseases [13, 14]. Because of that, in this study we analyzed three genetic variants (IRF5 rs2004640, rs2070197 and rs10954213) as representatives of three different IRF5 haplotype blocks [14]. To the best of our knowledge, our study constitutes the largest series of RA patients assessed for the potential influence of IRF5 polymorphisms in the risk of CV disease. Interestingly, when we studied each of the polymorphisms separately, our results revealed a protective effect of the IRF5 rs2004640 GG and IRF5 rs10954213 GG genotype variants against the risk of CV events in RA. Moreover, when we analyzed all the genetic variants together to create haplotypes, our results revealed a protective effect of the GTG haplotype (the one that carries both G alleles of IRF5 rs2004640 and rs10954213 polymorphisms) against the risk of CV disease. Because the protective effect of the mutant allele of the IRF5 rs2004640 and rs1095213 polymorphisms is seen only in homozygosis, we can conclude that our study is adjusted to a recessive model of inheritance. Additionally, the results derived from our study are in accordance with those obtained in other pathologies [20, 21]. In this context, the results of a recent study of individuals diagnosed with RA revealed an association between the IRF5 rs2004640 polymorphism and subclinical atherosclerosis [22].
The results obtained in this study provide additional evidence on the potential role that genetic factors may play in the development of CV disease in RA. The search for genetic markers associated with CV disease in RA may be important to establishing a better characterization of RA patients at risk of CV disease. Improved understanding of these underlying genetic may be useful to establish future therapeutic targets to decrease the risk of CV disease in RA patients.
Our results reveal that IRF5 gene variants are associated with CV disease in RA patients.
Authors' information
JM and MAGG share senior authorship of this article.
American College of Rheumatology
- Anti-CCP:
Anti–cyclic citrullinated protein/peptide antibody
Confidence interval
Human leukocyte antigen
Hazard ratio
Interferon regulatory factor
Rheumatoid arthritis
Standard deviation
Systemic lupus erythematosus
Single-nucleotide polymorphism
Tumor necrosis factor.
We wish to thank all the patients with RA who participated and made this study possible. We want to especially thank Sofía Vargas, Rodrigo Ochoa, M Luisa López, M Jesús Ibañez and Sara Olavarria for their technical assistance. This study was supported by European Union FEDER funds (European Fund for Regional Development) and the Health Research Fund (Fondo de Investigación Sanitaria grants PI06/0024, PS09/00748 and PI12/00060) from Instituto de Salud Carlos III (ISCIII, Health Ministry, Spain). It was also partially supported by Cooperative Health Research Thematic Network (RETICS) Program RD12/0009 (RIER) from Instituto de Salud Carlos III (ISCIII, Health Ministry, Spain) and by grants from the European Innovative Medicines Initiative Be the Cure (IMI BTCure) program. RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto Carlos III de Salud at the Spanish Ministry of Health (CD12/00425). FG and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013).
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


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Floral Design
Our floral department offers a wide range of styles to choose from to enhance your style and personality. Because every event is unique we tailor the arrangement to suit you! Browse through the site and let us know if you have a certain idea in mind.
Contact us if you have any questions about our arrangements or if you have something specific in mind.
Decor Services
Simply Elegant is proud to offer Calgary decoration services as a stand-alone service or as a part of your complete event package. We have a professional decor artist on staff who can talk to you about various decoration-specific projects for your event.
We take your vision and make it a reality.
Visit our Online Store
Be it catering, event rentals, special event products or event florals. Browse, add to cart and make your order right through our online store.
Our staff will respond immediately to confirm your order and organize the delivery for your event.
Our Team
Robert Vidra
C.E.O and Owner
Robert is a certified chef and has worked in the hospitality industry for over 35 years. He founded Simply Elegant in 1996 and designed each division to complement each other. He named Simply Elegant after Albert Einstein's theory "if we can describe the universe in a 'simple but elegant way' we can understand the universe." Simply Elegant has prospered due to Robert's belief and nurturing the staff community. With his leadership Simply Elegant has grown from its humble beginnings as a catering company to a full-range hospitality firm.
Sharon Barwick
Director of Special Events
Sharon is a Certified Special Event Professional (CSEP) and has been a manager with Simply Elegant since 2004 in the roles of operations manager, florist, decorator, wedding and event planner. Prior to Simply Elegant, she owned a successful Vancouver floral and event decorating company. As a key note speaker and educator in the event industry, she has been a member of the International Live Events Association for over 25 years. Sharon's range of expertise and natural ability to communicate with our clients makes her a valuable asset to our firm.
Peter Schwarz
Director of Food & Beverage
Peter received his "top drawer" training at the Hotel Management School in Leipzig, Germany and honed his skills during his 8 years at Kempinski Hotels and Resorts, one of the oldest European hotel chains. His previous experience ranges from being a tea expert to an extensive knowledge of Champagne. His calm, professional demeanor is perfectly suited for coordinating large, international catered events to small, intimate dinner parties. Our clients love Peter's attention to detail and personalized service when it comes to menu selection for their events.
Toni Guffei
Marketing Director
Toni oversees our marketing department from design work and social media programming to implementing other digital and traditional media campaigns for Simply Elegant. With more than 20 years experience in marketing and branding, Toni is also involved in marketing research and ROI estimates. She is experienced in measuring performance indicators for events. Plus she's been an adjunct professor for 10 years at MRU teaching courses in marketing, research and branding. Toni has a BA in Economics and an MBA in Marketing.
Jason Wareham
Executive Chef
Jason started his career in the hospitality industry in 1997 and graduated from SAIT's Professional Cooking Program in 2001. Jason has worked his way up from a Garde Manger at well-known hotel chains to the Executive Sous Chef at Fort Calgary before joining our team. Armed with innovative ideas and creative food menus, he sources fresh produce from local suppliers and makes everything in-house from scratch. We're proud of this work because he's elevated the Simply Elegant brand with his unique approach to preparing quality food for our customers.
Shelley Clements
Office & Accounting Manager
Shelley is the person behind the scenes keeping us organized by handling both the office and accounting functions. Shelley came to Simply Elegant with over 25 years in the industry where she did everything from being a short order cook, to serving and managing a downtown pub. Ten
years of working at the famed King Eddy taught her a great deal about music and, more importantly, people. After 10 years with Simply Elegant,
Shelley is a calm force during busy events. She has an eye for detail in our proposals and makes sure all the numbers add up.
Eduardo Cueva
IT Manager
Ed is a P.Eng. and an MBA who graduated from the Monterrey Institute of Technology and Advanced Studies, in Mexico. With over 20 years of Information Technology consulting experience in North and Central America and the Caribbean, Ed is in charge of our Information Network. As part of our team since 2003, Ed has developed our information infrastructure onto a private cloud system which integrates communications, productivity, collaboration, data protection and security. He makes sure all of our internal systems are efficiently managed.
Alexander Zagoumenov
Digital Marketing Manager
Alex has over 10 years experience managing marketing campaigns through digital channels such as display, paid search and social media advertising. He previously worked on client accounts including Rolex and Mercedes-Benz USA. Alex has a Bachelor of Management (Marketing) degree and is a certified professional in Google AdWords, Inbound Marketing by HubSpot and Social Media Marketing by Hootsuite. Alex has worked with Simply Elegant for the past 5 years and is responsible for website development and our online marketing.
Join Our Team
Join an accomplished hospitality company that specializes in Event Management, Catering Decor, Florals and Consulting.
Simply Elegant prides itself on integrity and ethical business practices. Managers lead by example by showing respect and working alongside their staff. Employees are given responsibility and the authority to do their job with opportunities for advancement. We offer an exciting, fun environment for individuals who want to excel and grow in the hospitality industry.
Simply Elegant is a community of people who work hard, enjoy their lives and have earned the right to be respected as professionals and friends.
About Us
We're Calgary's Premier Hospitality Firm.
We are Simply Elegant, an accomplished event and catering company headquartered in Calgary Alberta. We provide expert planning, catering, floral, decor and management services for all kinds of events, including private parties, corporate events, and weddings.
We are the Calgary wedding planner, event manager and caterer of some of the very finest private parties and corporate events. We love what we do, and we'd love the opportunity to see how we could make your life easier and your event the best it could be. You could say "We're in the Business of Events."
We started as a catering company in 1996. Owner Robert Vidra, a trained chef, came to Calgary determined to open a catering operation that met the specific needs of the business community. He talked to everyone from receptionists to the CEO's of Calgary's largest companies, designing a catering company that would best meet the needs of the Calgary culture.
The business developed a reputation for providing excellent food, outstanding service and tremendous value. In fact, the service was so good that Simply Elegant's clients encouraged the company to move into events, because of their unwavering attention to detail. Simply Elegant expanded into events in 2005, adding a nationally recognized, award-winning designer and events planner to the staff.
Now, instead of having to deal with a variety of vendors, clients are able to turn over everything to Simply Elegant, right from the early planning through to the decorations, catering, entertainment, execution and clean up.
We actively listen in order to understand the corporate culture and needs of our clients and create events that reflect their brand and values. We do not believe in "one size fits all." Rather, we customize events by working collaboratively with our clients. We never take for granted the trust that our clients and vendors put in us.
Simply Elegant staff are experts in their field. Numerous employees have enjoyed long-standing careers at Simply Elegant. We value their loyalty and support their continued education.
We have established strong, working relationships with our vendors and treat them how we want to be treated. We believe that honesty, integrity and social responsibility are vital to our corporate culture and seek out vendors with similar values. Our future includes caring for the planet and we actively seek ways to lessen our footprint on it. We are mindful of the environment as we design our events.
- Leadership starts at the top. It has always been the core principle of Robert Vidra to accept responsibility for all that happens and not blame others; all of our staff follow that same conviction.
- We enjoy what we do by creating fun and a little magic.
- Our business is not an object but a live entity; we are a community of people who love to work and socialize together.
- We believe that change is inevitable and by accepting the evolution of change, we can inspire others.
- There is nothing more important than communication.
- We are open to accepting constructive criticism.
- We accept that each person has strengths and weaknesses; we recognize the strengths of others and minimize their weaknesses by providing support and working as a team.
- Success is directly measured by those around you; we cannot be what we are without our staff and vendors – it's the people we work with that make us great.
- Each person is required to work in other departments so they understand the other divisions.
- We share in the joys of others and their lives.
- We are community minded and give time, money, food and services to the Calgary community and Hospice Calgary (whose work with those facing end of life challenges humbles us).
- We believe in doing the right thing even when it is not the easy thing.
- We believe business is earned and trust cannot be abused.
- Enlightenment through education brings out the best in us.
- We give employees company money to go out for dinners and experience new things that make them happy.
- Supporting strong policies since 1996; we did what was right before most people cared.
- We recycle, reuse and reduce.
- We do not take advantage of our vendors; it is through collaborating with them that we can succeed.
Simply Elegant's Green Initiative
There's no point being a premiere events and catering company if we've run out of planet to live on. So we take our responsibility to the environment very seriously.
Here are some of the ways we work towards sustainability:
- We support and purchase from local food products and suppliers
- We use organic vegetables where possible
- 90% of the meat we purchase is from Alberta, including free range fed chickens and turkeys
- 25% of all produce we purchase is grown locally in the Pacific NW
- 90% of the fruit we buy comes from North America
- We provide biodegradable disposable cocktail and lunch plates
- We provide "green" cutlery at client's request
- Since 1996, we've used chaffing dishes (not tinfoil) for all hot food
- We use plastic platters, which are sanitized and reused, instead of disposable ones
- Our food is presented on china by request
- All cardboard and office paper products
- Kitchen cooking oil
- Bottles and cans with proceeds being donated to local community groups
- Straight line food delivery for "green routing" to specific downtown corporate buildings to reduce fuel consumption, minimize vehicle exhaust plus conserve gas
- Strict maintenance programs for delivery vehicles
- Kitchen freezers, fridges
- Air conditioner units
We're glad a healthier environment matters to you too. Thanks for wanting to know more about our green philosophy. We'll keep striving to find new ways to lessen our footprint on the planet.
We Support
- Hospice Calgary
- Médecins Sans Frontières HK / Doctors Without Borders (MSF)
- Canadian Red Cross
- David Suzuki Foundation
- World Wildlife Fund
Our Location
Click the Pin on the map below to get the details or fill out a quick form to send us a note.
Simply Elegant News
Harvest to Table – A dinner party to support Hospice Calgary
Simply Elegant is a supporter of Hospice Calgary. To bring awareness to this cause and raise funds to support the organization, we wanted to do something special that would include our clients and colleagues. Our management team decided to host an event at our shop to...
Help the People of Fort McMurray
Hey Calgary businesses, Fort McMurray needs our help. Tens of thousands of people have been displaced from their homes and are at risk of losing everything. See the story here. Simply Elegant has made a $500.00 donation to the Canadian Red Cross and we invite, no...
Simply Elegant at Hike for Hospice
Simply Elegant is proud to once again partner with Hospice Calgary for the annual Hike for Hospice. This year's Hike was a huge success generating over $130,000 in donations! It was a beautiful sunny day in Calgary's Fish Creek park. Over 600 happy hikers were...


text:
According to the United Nations, hundreds of children have been killed and thousands more injured.
Izzeldin Abuelaish has been touched by this conflict in the most profound and painful way. In 2009, he lost three daughters, when his apartment in Gaza was hit by a shell from an Israel Defence Force tank. But unlike so many others, Dr. Abuelaish rejected the politics of hatred and revenge, and instead committed himself to reconciliation and love.
Now Dr. Abuelaish is working to bring injured Palestinian children from Gaza to Canada for treatment.
Tom Mulcair spoke with Dr. Abuelaish and pledged the New Democratic Party's support for this cause. Now it's time for Stephen Harper to take immediate action.
Add your voice to the call.
We the undersigned residents of Canada note the following:
Therefore, we call on Stephen Harper and the Government of Canada to take immediate action to help enable Dr. Izzeldin Abuelaish's humanitarian initiative.


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Would you like to save as your currency permanently or for this visit only?
friendly and helpfull staff, clean beach, nice food, interesting events
the beach the kichen
beautiful garden, swimming pool; nice sandy beach poor noise isolation in the rooms; little greek specialities in the buffee
Their private beach and very clear beach In three nights staying they didnt change our towels at all. We know that the 4 stars hotel they change it daily basis
big parking area, friendly staff, amazing beach, excellent service maybe bigger swimming pool
I loved the proximity to the beach, the cleanliness of the rooms, and the tranquil atmosphere. I really loved that you weren't piping music to the beach. I loved the water, swimming, and then coming back to a clean, comfortable room to relax. The food was not very good at the outdoor restaurant and the shower needs a shower curtain. I also did not understand why the beach is not always all-inclusive of the room price (we had to pay to be there and were told that only deluxe type rooms had full access to the beach).
Pleasant and clean hotel with great food beutiful beech
The hotel is big, specially good for families with small children, a really great staff, and what we liked the most it has excellent beach. We travelled with a six months old baby and had nice and relaxed holiday. Even though the food is good the menu could be more varied, especially regarding dinner.The prices of drinks are unreasonably high.
Lots of eastern european staff that my russian wife could talk to. Hertz car hire point. Good beaches with plenty of space even at peak times Not too sure about the cooking -but there are restaurants for the fastididous albeit at a small surchage. Price quoted by Internet 300 euros less than I actually paid.
The location of the resort is simply amazing. I stayed six nights and I could not get enough of the facilities. I was particularly impressed by the nearby marina area which is part of the resort. The food was very good. The room cleaning service could be faster. Some days, the room was not cleaned until after 2 p.m. Drinks at the restaurant were expensive and so were snacks at the beach and pool bars. Most of the staff did not speak Greek.
Range of food available on the buffet, Style of hotel Prices were very expensive and no details about what food was being served in the restaurant.
we enjoyed meeting all the international staff and learning about them and their countries. we didnt like having to make reservations for our dinners. we like to eat when we get hungry.
Great place for holiday
The staff were delightful and very helpful, the resort was well planned, the facilities provided were good, the resort was well maintained The area around the hotel is pretty grim and a car is an essential requirement if you want to venture beyond the resort itself. We were the last guests to leave (NOv 1st) and the availability of a a variety of foods diminished considerably as the week progressed.
The pool and beach combination was great. The hotel is fairly smal and the grounds are easy to navigate and use. The menu at the beach bar was very limited and not representative of the greek cusine and definately not suited to a five star hotel rating. The dinner menu was just as limited and lacked flavor and freshness.
Some of the best things at this hotel were the excellent rooms, the very nice pool, a beautifull beach and the very friendly staff members. Some other reviews I read say that the staff members try too much or that even sometimes they are not friendly. What I have to say is i) trying too much is never bad and ii) the visitor also needs to be friendly to the staff as they are human - what you give is what you'll get if you know what I mean. the price was good but I did not stay during high season. Based on the prices I saw for July - August I could say it's a bit overpriced but it's definitely a super deal for May - June - September.
A five star hotel provides its guest with a kitchen that operates after 2100 hrs that enables guests to eat. If not, it is NOT a five star hotel!!!! The opening hours of the kitchen needs to be improved as well the quality of food offered in the poolbar/restuarant, if not, the hotel can not continue to be advertised as a five star hotel.
Close to beach, friendly staff, clean rooms, good food & drinks, nice views (especially sunsets) Not a 5 star hotel at all. People at reception should lear to walk the talk and not just pretend they are customers oriented.
Very good pool and beach side facilities Over priced bar meals and drinks
Nice hotel, friendly stuff and very comfortable and well cleaned rooms with nice decoration. The suite had two beds instead of one king size bed and the internet connection mostly didn't work.
Comfort and beach Services
fitness romm or bycicle way on description hotel write we have wireless internet,and in reality it was not :)
We liked the beach and the facilities there;new furniture in the entire hotel and our big terrace. There is no wireless internet in the entire hotel as it mentioned in Booking.com-only in the lobby of the hotel.We didn't understand if sauna and fitness room were existing in the hotel.
design of bulidings, of the site, room, inlcuding bathroom. Many many things . But you say that I am not allowed to complain . So, what could be something I didn't like which is no also a complaint ? If could more specific, I will be able to answer this question. Anyway, I recommend this hotel in 2-3 years from now. For now, they seem to me as a beginers . Beautiful site, not asa much beautiful service and organization.
Great Value for Money ,friendly stuff all around. One of the best places to relax
the hotel's beach the food
The room is perfect, with a panoramic sea view. The beach is clean and the water is beautiful.The hotel is not far of Kalitheea and Afytos.There are a lot of tavernas and shops for souvenirs in Kalitheea.If you are by car, you can also go to Petralona cave, which is aprox 45km from the hotel. The breakfast is not diversified, you have the same dishes every morning and you have to ''hunt'' the vegetables, as you can't find them all the time.The indoor pool with the dome is a joke - it's closed during day, it's small, it smells weird inside.The outdoor pool is not cleaned every day and it has a lot of sand on the pool bottom and dead bees. The sunbeds are not very comfortable as they dont have any cushion and you have to pay 7.5eur for a sunbed with umbrella on the hotel private beach.
Very very noizy. Mosquitos everywhere. No internet in rooms.
Nice beach Better stuf ,no rude reception and waiters,better furniture
The second time we have stayed there - first time two years ago. The beach and sea is perfect. Small towns nearby good for shopping and restaurants. This time the other guests were predominantly Russians and Macedonians, rather than Western European. Something of a culture shock! Also local traders have become extremely expensive; fruit is at least 5 times proper local market prices, and fish restaurants are charging 60Euro per kilo for fish. There may be a financial crisis in Greece but this was outrageous.
The beach,animation team, and the room ventilation in the elevators
It was only one night, but it's enough to feel the positive energy and the good hotel operation! Check in was fast and friendly, bell boy escorted us to the room, (our beautiful room with big bathtub), Beach was clean, cocktails were refreshing and dinner in Akrogiali Tavern with fresh fish and good wine was the best closure of the evening!! Thank you all very much and we promise that our next holiday is with you again!!
Great Value for Money
The beach was excellent with crystal clear water , the variety and quality of food available for evening meals was also execllent.
We had a nice time at this beautiful location! Cleanliness was a big + !! Clean room with fresh towels, not a single dirt in corridors and complex generally! Nice beach, although we prefer the pool. Trees, flowers, gardens all over the place. Peaceful although so near the clubs
pool services
Great Value for Money
The hotel has a good location, it was clean and has a fantastic view to the sea.yoy must pay the umbrella at the beach. The boufes was very small for the size of the hotel and the food is very poor. το φαγητο - μπουφε- περισσοτερεσ ομπρελεσ
Very nice staff and room. The best about the hotel is the close location to the Halkidiki's best clubs of the summer season. Food of the half board.
Animation team
Great Value for Money
So Medieval!!...It felt like we stayed in a Castle! Really romantic candlelit dinner for 2 in Italian Trattoria, lovely sunsets by our sea view balcony, I totally lived my fairytale in a weekend getaway!! I only wish we could stay more!!
Only the view of the beach from my room on the 8th floor. Nearly all areas need improvement: facilities, room design and cleaning, personnel, food, pool. Wireless internet is not free at the lobby in contrast to what is advertised on Booking.com
Location Only Bad Service
Relaxing atmosphere, good buffet breakfast with big variety, plenty of swimming pools so they were not overcrowded. The umbrella and sunbed charges at the beach were not acceptable for such a five star hotel. Also, although it mentions that parking is available, the parking is available only for owned cars and not for rented ones. Finally, in our bedroom there was only one thin white curtain and unfortunately everyday we were waking up very early from the sunlight. They should have had two sets of curtains.
Services and facilities in general were of high standard, especially the food. My room was impeccable.
The environment is very nice, very careful preserved, the rooms are also nice, the position of the hotel is also good, near to many beaches of Chalkidiki and to the "cosmopolitan" Kalithea. There was a problem with internet. They don t have internet in rooms, as they advertise, plus the wireless of the reception didn t operate at all. It s unbelievable a 5stars hotel not to provide u internet access in our times. Also I think is overpriced for what it offer to you. The restaurant 's boufet it was very big but I don t believe that it was respectively tasteful.
Outdoor pools are very good; the breakfast and dinner are very quality; Hotel staff is unprofessional except in the spa and bell desk; working time of the sauna is short; they need to improve the gym; the entrance in the sea should be clean from the stones;
Great combination of nature with luxury. Excellent organization, beautifull space No
The location was great and the hotel grounds were very nice. The room furniture was very old looking and outdated. Food was OK. Buffet style. The beach was nice. We did not use the beach chairs at all since the fee is $10 and for a family of 6 it's not worth spending that much money. We did go to the beach but just to swim. The hotel pools have salt water as well. Old looking furniture. Outdated rooms. Poor TV Chanel selection. Horrible Internet/WiFi. Average food.
everythink iz ok
The room was very comfortable and situated near a green park and near the sea, the food was rich in asortiments. There was no activity after the dinner and you have to pay to stay at the beach.
Location, hotel staff I should clarify:There 2 location, one is far from the sea and another is very far from sea (over the road). One restaurant was closed and it was in use only one, not enough for all the people. Due to that, the location was very crowded, the waiters service slowed. It is definitely not a 5 stars hotel!
It is a very confortable hotel for family situated in a nice place.
Beutifully placed hotel with low appartments , in the green next to the white beach. The hotel staff were excellent especially the guys driving the golf carts made all the guests feel special. The reasturant for dinner was always very crouded . I beleive it needs another restaurant.
Position, view, breakfast, cleanliness, beach. Bar staff not polite. Nobody on the premises at night, when fire alarm started and nobody was there to stop it. Noisy wedding party Saturday night prevented us from sleep.
the atmosfair,and the silance
- position, very close to the beach - very clean - friendly staff - good breakfast - nice pool
it was honestly great stay, hotel is beautiful in a calm place , perfect for relax and the countryside is amazing, we would louve to come back next year for holidays for sure!!!!
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I liked everything about the hotel.
fantastic see view, big terrace, nice design of the hotel and the room, good location
The quiet attention of the very pleasant staff, the wonderful location, view and setting of the hotel. Just a perfect short break location and really child friendly. I have been coming for 6 years and the quality and service remain consistently top class.
The garden and the sea view is nice. The breakfast buffet was very poor. The restaurant staff closes the buffet at 10:00am Greek time, and they always argue with guests who object to this. The hotel manager is very unfriendly, and they don't respect their guests. The Internet is very expensive. The pool was not clean. There were wasps and mosquitoes around the pool and in the room. The beach is only accessible by 160+ steep stairs. There is no entertainment or activities in the hotel. The hotel is 2km far from Afitos, and the road is dark and unsafe. This is not a 4-star hotel, and it has no service and no value for money.
Great view from a suit, spacious rooms, clean. Friendly staff. Comparable in quality with Sani Beach Club, though in 30 min drive from Sani Resort. Walking distance to Athytos old town, where there are plenty of taverns and nice views too. One of the best places in Khalkidiki! Nothing really, besides going to the beach via a stip stairs will be challenging for older people and young kids.
Good location in quiet area. Stuff very kind. Special thanks to Dean and Kristina
Very quite place! The sofa of the beds are not confortable.
The breakfast was good and the location was close to the beach. It had a nice atmosphere and pool. The first room we were given had water damage near the bathroom and had a very musty / mold smell. The second room we were given didn't have functioning airconditioning though the staff insisted that the room temperature air it blew out was actually "air conditioning".
Nice accomodation, very confortable. Very convinient for families with young children and people who likes peaceful atmospehere. Nice staff who were always at our service. There is a risk of your unsatisifaction when you get there, as not all rooms are same. Some of them are very nice ( nice view of the pool area , close to restorant , two separate room in each suite), but some of them does not worth 30 % of their price. ( one room suite, basement located, without sunshine troughout all day). So be carefull if possible call there and put attention to particular room you want. On more think is that we discovered that you can get better rates for this hotel if you call them directly as some other peple done who we met at the hotel, especialy for the hotel dinner which cost 27 eur per person per day through booking.com, and 15 eur in hotel. For the price of accomodation same.
I enjoyed every single moment!
I've enjoyed the room which was large with a nice view. The reception staff was helpful They start doing cleaning at 730
Its like goverment officers summer camp I never fill this form after my booking.com bookings this time I did for claiming. Specially registration vas too bad its more like immigration office then an hotel front desk
the beach There are still reconstractions work . This hotel at the moment is very far away from 5 star hotels, and the price is not equal to services and facilities.
Not worth the money paid. Expensive and not even a bottle water to be found in the mini bar.
Accomodation, beach, garden Breakfast
Location - directly at sea shore, newly refurbished interior and exterior, plenty of space and green around buildings, two outdoor pools, well looked after overall. For some reason electrical board in room was producing constant noise. Breakfast ends too early for holiday hotel - 9:30.
not is 5 stars hotel
The room interior and the furniture were really good and the bed was comfortable. The breakfast was not so various for a five star hotel.
The pools and the comfort of the room was ok.The TV was way too small and the picture was with snow,so there wasn't a chance to use it all. The TV was way too small and the picture was with snow,so there wasn't a chance to use it all.The choice for the food for breakfasts was not for five stars hotel.When we left the room at the end,we forgot something in the room and the receptionist made my girlfriend go five times to the room with diferent cards,and we lost 2 hours, till we got the thing.
Location - on the sea shore, facilities - a few pools, gardens, vast green belt around, newly refurbished and luxury interior, perfect aircon. Room minibar and elctrical board are producing constant noise (not very loud, though). A bit of a shortage of sun chairs at pool and beach.


text:
Driver escapes injury when Audi overturns in Horringer
19:20 22 January 2016
A car overturned when the driver lost control of the vehicle in a west Suffolk village.
Police were called to The Street in Horringer at 5.40pm to reports of a single vehicle collision involving a blue Audi.
A spokesman for Suffolk Constabulary said the driver lost control of the car.
The motorist was able to get out of the car and was not seriously injured, the spokesman added.