text:
Hello 2017, hello stinking cold, hello new year paranoia and feelings of hopelessness and defeat.
God knows why I cant just ride this tide of familiar doubt – but every year it knocks me sideways, basically I should never stop working, because whenever I do, getting back in the saddle feels incredibly hard.
I finished my Autumn tour of How To be a Middle Aged Woman (Without Going Insane) on December 5th and to be honest I had a complete ball on that last leg, culminating in a wonderful night at the Royal Festival Hall at the end of November. God what a glorious space to play and how gratifying and what a relief it was to see so many people turn out on what was such a filthy night- so thanks to everyone who came, including lots of friends and family (plus the old man who sat in the bar for the duration, nervously drinking gin).
Royal Festival Hall
Anyway, I shall be back out on the road with the show from the end of January and will be taking a shortened version of it over to the Melbourne comedy festival for three weeks in March/April- so that's exciting- I love Melbourne and even though I will be gigging every night, I've got a nice early evening time slot so I should be able to catch some other shows and have dinner out and be a bit la di da – the old man shall be escorting me and he is already looking forward to the breakfasts (they serve 'em big in Oz).
I should also be writing another novel this year, I say 'should' because so far, I'm finding it tough and even thinking about it makes me feel weepy, I've had four novels published so far, so you'd think it would get easier, but genuinely I have no idea how they happen, its like accidentally pulling off a magic trick and desperately trying to remember how you might have done it.
I've also got four more Little Lifetimes to record for radio 4 in addition to the book version, 'Listening In' which comes out in the summer. This is a collection of all the Little Lifetimes pieces broadcast so far (17 of them) plus seven brand spanking new monologues – so 24 short stories in all, all of which I've been allowed to illustrate- so look out for some very wonky drawings and an even wonkier hand painted front cover!
Painting and tapestry were a big part of getting me through 2016, I'm a great front seat passenger needle woman and I intend to do a lot more this year, much to the disgust of my brother – God you should have seen his face when he got my hand woven sea shells cushion cover for Xmas.
The woven sea shell tapestry I gave my brother for Xmas
I'm also going to tackle the oil paints which I got for Xmas, but at the moment I'm a bit scared of them, basically I daren't have a go in case I'm completely rubbish, I think there's a lot of technique to oils and I've been confused by various YouTube tutorials – maybe I'd be better off just diving in.
And that's another thing I need to do more of – once upon a time when I was pretty and pert I did a lot of yoga and a lot of swimming, well me and the girl did a yoga class between Xmas and new year and it was so hard core that the next day I couldn't lift my arms above my head, this felt weirdly good and once I've got rid of this cold I'm going to try and get back into going a lot more regularly – SO I SAY… God it's hard isn't it, to do the right thing, even when you know what the right thing is.
Anyway, just to bring us up to date, I had a lovely family Xmas – and I actually mean this – my mother came to stay for five nights which turned out to be really lovely, my mother is 87, great company and one of the least daft women I know – if that makes sense and she was incredibly game and up for stuff, including cards against humanity! ( look it up) She also makes the best German red cabbage in the land.
Unfortunately my mother has mobility issues, so thanks to Tate Britain for lending us a wheelchair so that she could see the Nash and the Turner prize in comfort, let's face it, my Mum's brain is in great nick – she pronounced the Turner prize contenders as 'dreary' (have to agree) but sadly her legs are too weak to schlepp from floor to floor, the wheelchair made the trip so much easier and was done with absolutely no fuss or bother.
My mother learns to photobomb
So Xmas came and went in a whirls of cheese and presents and as per usual new year feels like a crashing come down so cheers to the Horniman in South London for chasing away the 2nd of January blues, with its hilarious collection of taxidermy and lovely little £4 entrance fee aquarium – also enjoyed the Rauschenberg at Tate Modern, just the Gavin Turk and the Anselm Kiefer to tick off in the next couple of weeks. Ooh yes and me and the old man had a lovely pre Xmas ballet treat when we went to a Sunday afternoon matinee of Mathew Bournes' The Red Shoes'- god I love a Sunday afternoon matinee.
Horseman Aquarium
I love living in London, I love the fact that all this stuff is on my doorstep and yes the place stinks and I'm increasingly scared of terrorism and how much everything costs but I love it and I'm lucky to live here.
That said I do want to visit japan this year – the aim is the spend a couple of weeks in Autumn having an adventure, let's see if this actually happens, I'm a bit cowardly when it comes to travel and at the moment just getting out of my pyjamas is a bit of an ordeal, so while I go and dose myself up, here's to a happy and safe 2017, fingers crossed it'll be ok.
Oh btw – I learnt to cook some new things in 2016, not only have my soup skills improved but I can now do a beef bourgingnon and a chicken curry and I'm only 56.


text: Garbage built on the sonic landscapes of My Bloody Valentine, Curve, and Sonic Youth, adding a distinct sense of accessible pop songcraft. The band was the brainchild of producers Butch Vig, Duke Erikson, and Steve Marker, who initially held an informal jam session in Marker's basement, but they eventually recruited vocalist Shirley Manson, who had previously sung with Angelfish and Goodbye Mr. MacKenzie. Vig is a native of Viroqua, Wisconsin, who learned to play piano as a ch... Read more

subset: commoncrawl


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Lot 3118: Qing (after Ming) Wucai Fruit Box with Cover
Watches & Jewellery, Fine Chinese Paintings & Works of Art
by Gianguan Singapore
30 October 2016
11 Cavenagh Road, SingaporeLive Auction
Past Lot
Looking for the realised and estimated price?
Qing (after Ming) Wucai Fruit Box with Cover
清仿明五彩果盒 高 (Height): 10.7cm 宽(Width):20.7cm
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frameless glass doors barking
frameless glass doors in barking
Our experienced and friendly staff can quote you immediately to replace any glass in any window or door, single or double glazed (DG Guaranteed for 10 years) all of our work is fully guaranteed. We offer an emergency service at no extra cost. Within the hour or at a time that suits you.
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July 23, 2014
USTFCCCA Division I All-Academic Awards
LONG BEACH - Long Beach State track & field had six individuals receive 2014 USTFCCCA All-Academic recognition, while both the men's and women's squads were selected as All-Academic Teams the U.S. Track & Field and Cross Country Coaches Association announced.
The Beach women garnered All-Academic Team honors for the 10th-consecutive season with a cumulative team grade-point average of 3.01, while the LBSU men earned the award for the second-straight year with a 3.04 team GPA.
In addition, six 49ers - Fatima Vergara, Kayla Kamaka, Alex Kruthers, Conner Rouse, Brandon Hierholzer and Dylan McCloskey - received individual USTFCCCA All-Academic accolades. To be eligible for all-academic honors, student-athletes must have compiled a minimum cumulative GPA of 3.25 and have participated in any round of the NCAA Division I Outdoor Championships.
Vergara was the Big West champion and an NCAA West Preliminary qualifier in the hammer throw. She claimed the conference title with a toss of 189-04. Earlier in the year at the Ben Brown Invitational, Vergara registered a personal-best 192-02, which ranks third in school history. Vergara is an upcoming senior and is majoring in community health education.
Kamaka qualified for the NCAA West Preliminary in the pole vault after clearing a personal-record 13-01.5 at the Anteater 4-Way Meet. She is tied for second on the LBSU all-time top-10 list as she became just the third 49er in program history to reach 13 feet. Kamaka recently graduated with a degree in kinesiotherapy.
Kruthers advanced to the NCAA West Preliminary in the 400m after establishing a lifetime-best 54.34 to finish fourth at the Big West Championships. That mark ranks second in program history. Kruthers is majoring in psychology.
Rouse was the Big West champion in the pole vault and tied for 30th at the NCAA West Preliminary. He notched a personal-record 17-00.75 to earn top honors at the conference meet, while he also cleared 17-00 to win the Triton Invitational. Rouse, who will be a junior in the fall, is majoring in studio art.
Hierholzer was the Big West runner-up and an NCAA West Preliminary qualifier in the pole vault. He established a lifetime-best 17-00.75 at the conference championships. Hierholzer graduated with a bachelor's degree in kinesiology in the spring.
McCloskey advanced to the NCAA West Preliminary in the 400m and as a member of the 4x400 relay team. He earned All-Big West honors in the 400m and both relay events, while also scoring in the 200m with a top-eight finish. McCloskey is an upcoming junior and is majoring in sociology.
Sport Links
- 2016 Season
- Season Bests (Updated June 13)
- Weekly Release
- 2016 Black and Gold BBQ
- 2016 Black and Gold Schedule
- 2016 Cross Country/Track and Field Banquet
- 2016 Alumni Meet Registration
- 2016 Beach Kids Meet Registration
- 2017 Annual T&F Sports Package
- Beach Invitational Homepage
- Home Meet Information
- Black & Gold Meet Results
- Official Facebook Page
- Follow on Twitter
- Recruits
- Recruiting Information
- Men's Track & Field Questionnaire
- Women's Track & Field Questionnaire
- Contact Information
- Head Coach Andy Sythe - Jumps, Multis
- Tom Walsh - Distances
- LaTanya Sheffield - Sprints, Hurdles
- Cory Loebl - Throws
- Related Links
- USA Track & Field
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- TrackWire.com
Media Guides
CoversCovers & Introduction
Section 1Coaching Staff
Section 2Meet the Men's Team
Section 3Meet the Women's Team
Section 4History & Records
Section 5Welcome to the Beach
More Headlines
Shawn Winget Hired as Cross Country/Assistant...08/08/2016 - Track
Long Beach State head coach Andy Sythe has announced the hiring of Shawn Winget as the program...
Beach Track & Field Earns Team and Individual...07/28/2016 - Track
Long Beach State track & field had four individuals receive 2016 USTFCCCA All-Academic...
Long Beach State Track & Field Alums Set for U....06/30/2016 - Track
Long Beach State has four alums who qualified for the U.S. Track & Field Olympic Trials in Eugene...
Long Beach State Track & Field Signs Three More...06/13/2016 - Track
Long Beach State track & field has announced the signing of three more student-athletes to...
LBSU Track & Field Nets Three USTFCCCA...06/13/2016 - Track
Long Beach State had three individuals earn honorable mention All-America honors the U.S. Track &...
Riley Cooks Finishes 20th in Heptathlon at NCAA...06/11/2016 - Track
Junior Riley Cooks finished 20th overall with 5,372 points in the heptathlon to wrap up the NCAA ...


text:
Rushing is for the ignorant,
But they say ignorance is bliss.
I feel the need,
For an unnecessary survival.
I know more than you,
Yet together we're both blinded by our insecurities.
You are a black King of Clubs,
As am I a red Queen of Hearts.
The compatibility;
There simply is none.
Easy to deny from a few feet away,
But as inches grow near....
For my confusion,
Has drove me mad.
The heat boils within,
Yet there is no surface.
You've never spoken your name,
But I know it.
You've never opened your mind,
But I see it.
I open my door for no one,
Yet you have a key.
Are you here to steal,
Or simply rescue?
What ever it is I feel,
Is never harmful.
Is there hope for me,
Or am I naive with creativity?
Have I lived in a dream for so long,
That I can't tell true reality?
Why you're here,
I'll further evaluate.
But for now,
Just stay and give me what I hate to want.
© Copyright 2017 ToLoveIsToHate. All rights reserved.
Status: Finished
Genre: Poetry
Book / Romance
Book / Romance
Book / Editorial and Opinion
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text: Make Delicious, Snappy Sichuan Green Beans Without a WokClaire Lower3/28/16 6:30amFiled to: FoodBroilerGreen beansSichuanClever uses72EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Sichuan style green beans are tasty, but they usually require a wok and a good bit of cooking oil. If you don't own a wok (or simply don't want to deal with a bunch of oil) they may seem out of your grasp but, over at Serious Eats, Kenji (of Food Lab fame) has devised a way to get vibrant, blistered beans using your broiler. Advertisement Part of what makes these green beans so exciting (yes, green beans can be exciting ) is their crispy, browned exterior and tender, but still snappy inside. Mushy beans are unacceptable, which is why deep-frying followed by a quick stir-fry in aromatics has long been the preferred preparation.To make a blistered bean without all of the excess oil, Kenji tested six different methods, ultimately deciding to move the operation out of the frying pan (or wok) and into the oven: Advertisement I figured that if I were to preheat my oven enough, I might be able to get a similar effect by tossing my beans in a little oil and throwing them in for a few moments. The regular oven, even when heated to its maximum temperature of 550°F didn't cook quite fast enough—the beans still turned soft by the time they were blistered—but the broiler-cooked beans were fantastic. By letting the broiler heat up to inferno-levels, then placing the beans as close as possible underneath, I was able to get them to blister and brown in record time.Next, Kenji turned his attention to the sauce, which you can read all about in the link below. Spoiler alert: it also can be made without a wok, meaning these beans are a very real, and very exciting side dish option for you to make tonight.The Food Lab: For the Best Sichuan Dry-Fried Green Beans, Ditch the Wok and Turn on the Broiler | Serious Eats Sponsored Photo by J. Kenji Lopez-Alt.Claire firstname.lastname@example.com@clairelizzieStaff writerGear from Kinja DealsYour Top Five Picks For Best Carry On LuggageBestsellers: Antec Bias LightThis $13 Box of Peppermint Patties Should Last You At Least a Couple of DaysReply7 repliesLeave a reply


text:
Game size: 2.86 MB
Suggested AgeAll Ages
Dollar Cubefield Free Download - PC Game Overview
Now you can get rich by using your agility and reaction skills right on your PC by downloading it and playing anywhere, anytime. Fly through a field of cubes making money for every second that you stay on! Grab extra money by picking up US Dollar signs! The faster you move the more money you make. Submit your score - show others what you got!...
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Daily 10am–4.30pm
Closed Good Friday
and Christmas Day
Get immersed in the busy world of bugs through play-based activities and storytelling.
Make, mingle and pick up some fresh skills at our Test Lab tinkering space during this adults-only event.
A specifically tailored evening for Cub Scouts to help obtain the Level 1 Space Badge.
A program designed for Cub Scouts to achieve the Level 1 Engineering Badge with a visit to Scienceworks.
An early years STEM workshop to inspire your little learner to think big.
Don't miss Test Lab - a temporary, pop-up, making and tinkering experience for older kids.
Roll on up to test out our Rollbots!
Working in pairs, get hands on with Sphero robots in this intensive workshop – exclusive to Museum Members!
Delve deep into LEGO® Mindstorms® EV3 robots in this intensive workshop!
From blue jets to red sprites, anvil lightning to St Elmo's Fire, explore the remarkable properties and mysteries of lightning.


text:
Creative Displays Stick Metal Shelves Storage Shelf
Sold Out
Another beautiful display idea - this metal storage shelve is a must for any fashion conscious home owner. Stylish and modern, the stick allows you to display your books, CD's, DVDs, or ornaments in a high quality frame. Each side is open to make it really stand out from the wall. Perfect for adding definition to any bedroom, living room or entry hall.
Made from high quality metal, it is available in a choice of 4 colours and 4 sizes, Choose from the following shelving: stick - the square, high stick - the tall rectangle or large stick - the long rectangle. Use the shelves seperately and it will create a beautiful art piece but use them together and you can create your own highly unique masterpiece.
A must have for those who have no storage space, they are perfect for homes where space is minimal. Stylish and contemporary, these beautiful metal storage shelves are guaranteed to be loved and commented on by friends and family alike.
Stick: 28cm x 28cm x 8.5cm £35
High Stick: 36.5cm x 19cm x 8.5cm £30
Long Stick: 59cm x 28cm x 8.5cm £55Estimated Delivery Time: 1-2 Working Days; GTIN: 5055618019840;
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Rusty Cooley, is an American guitarist from Houston, Texas, United States, known for his highly refined guitar technique. He is regarded as one of the fastest guitarists in the United States and a master of the "shredding technique of guitar.
Originally released in 1985 "Power From Hell" came into a time when satanic imagery was labeled "childish Venom worship" and Black Metal was a swear word terrifying musicians labeled as such. Their convincing powerful Black Thrash is as enjoyable in 2005 as it was in 1985.


text:
Form teams to complete special cooperative scenarios.
Starting with a few credits and a basic starship, carve your own path through the richest, largest gaming sandbox ever created, set against a backdrop of raw anarchy, galactic powerplays and intrigue. Do whatever it takes to upgrade your ship�s hull, engines, weapons, defences, cargo hold; even the ship itself, constantly improve your capabilities and influence on your journey towards the most coveted rank in the history of gaming - 'Elite'.More Info @ PCGamingWiki
This page contains co-op info for Elite: Dangerous on the PC. All information about Elite: Dangerous was correct at the time of posting. Information is subject to change. If you see any errors please email us.


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Closeouts. Your family will thank you when you upgrade your next camping trip with Kelty's Palisade 4 tent, featuring a cool dual-entry vestibule design with pull-down shades and cup holders.
Do you own this product? Write a review and help others with their buying decisions!Write a review
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The American Arbitration Association (AAA) has released new rules establishing an optional appeals process for parties involved in arbitration. Effective November 1, 2013, the Optional Appellate Arbitration Rules (Rules) afford parties an opportunity to seek review of unfavorable arbitration awards before an appellate arbitral panel. The Rules describe the process and requirements for parties wishing to have a decision reviewed in appellate arbitration.
The new Rules offer an alternative to the narrow grounds and limited scope of judicial review of arbitration awards. Typically, a court will not vacate an arbitration award except in rare cases where: (1) the award was procured through fraud, corruption, or undue means; (2) the arbitrator was plainly biased; (3) the arbitrator was guilty of misconduct in refusing to postpone the hearing, upon sufficient cause shown, or in refusing to hear evidence pertinent and material to the controversy; or of any other misbehavior by which the rights of any party have been prejudiced; or (4) the arbitrator exceeded his or her powers.[1] While these bases pertain to the fairness of the arbitration procedure, the new Rules permit appeals on substantive grounds.
Parties who adopt the Rules can now appeal on the grounds that the underlying arbitration award is based on (1) material and prejudicial errors of law, and/or (2) "clearly erroneous" factual determinations. Further, the appellate arbitrators will apply a comparable standard of review to an appellate court reviewing a trial court decision. Thus, arbitration subject to the new Rules more closely resembles the appellate review process found in the courts, but promises an expedited, cost-effective review process.
How to Appeal
Importantly, the AAA or the International Center for Dispute Resolution® (ICDR®) will only hear appeals of arbitration awards when all parties expressly agree to the Rules by contract or stipulation. Without such an agreement, a party cannot unilaterally appeal an arbitration award. If, within thirty (30) days of the underlying arbitration award, a party decides to appeal, the appellant must:
The AAA will choose an "appeal tribunal" from its "Appellate Panel," which includes former federal and state judges and other arbitrators with strong appellate backgrounds. There is some flexibility in the appointment of arbitrators. Parties can appoint the tribunal themselves, or follow the AAA's appointment procedures if they do not agree on a tribunal. The AAA will appoint a panel of three arbitrators, unless the parties decide to use only one.
The appellate tribunal will consider the merits of the appeal on written documents, without oral argument. Still, if necessary, the tribunal can elect to hear oral arguments or the tribunal can honor a party's request for oral argument. The Rules also require the parties to compile a record on appeal. After considering the record and the appellate briefs, the tribunal will either: (1) adopt the underlying award; (2) substitute its own award for the underlying award; or (3) request additional information and exercise an option to extend the process for no more than thirty (30) days.
The Rules aim to promote arbitration as an easy, fast, and efficient forum for dispute resolution. The AAA states that the appeals process can be completed in roughly three months. It appears the Rules also carve-out an exception and are not applicable in the context of disputes arising from standard contracts for consumer goods or services.
The new Rules bear some significant costs. Excluding the $6,000 administrative fee, the appellant may be assessed the appeal costs, and other reasonable costs of the appellee incurred after the commencement of the appeal if the tribunal determines that the appellant is not the prevailing party. This can include attorneys' fees if the contract or a statute provides for such. Therefore, the appellate process seems best suited for parties involved in large, complex cases, for which the Rules were primarily designed.
Moreover, parties wishing to adopt the Rules should consider obtaining resources to maintain an adequate record. The Rules require parties to compile a record and also allow parties to submit expert reports, deposition transcripts, documentary evidence, excerpts of the transcript from the underlying arbitration, and other relevant evidence. Since an extensive record may come at a high expense, the new Rules seem most appropriate for large or important cases.
Presently, some employers have pre-dispute mandatory arbitration agreements in which employees waive their right to a judicial forum in all, or many, disputes. Those agreements may provide for AAA procedures and arbitrator selection; however, the new appellate Rules do not apply unless the parties affirmatively include them in such agreements. Accordingly, employers should be aware of the Rules and how adopting the Rules in an arbitration agreement may affect the cost, length, overall process, and outcome of arbitration.
[1] Federal Arbitration Act, 9 U.S.C. § 10.
See more »
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
© Proskauer Rose LLP
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Hotels in Cata, Slovakia
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- Most bookedHotel Château Béla
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"If you're looking for a very quiet beautiful place away from all the big cities right on the Danube this is the place to be. You're between Visegrad and Esztrgom about 40 km up the Danube River from Budapest. This is a spa hotel with five saunas and pools. You will need a rental car in order to m..."
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"We had stayed 3 nights in the hotel and we were expecting better value for our money. The hotel location is outside of the city and need a while to walk into the center, but it is close to the forest for people want to go into nature. The long drink prices in the hotel are more as it would be mos..."
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text:
The bus jolted to a halt and the chatter on the bus got slightly louder.
"I'm going to miss my lunch appointment if there are any more traffic lights." Said the old lady with a sigh. She was sitting in the seat next to me and was wearing a calf-length tweed skirt, black sandals and a crocheted cardigan over a white blouse. She had a kind face with smile lines around her clear blue eyes, snowy white hair cut short and a laugh the was infectious. She smelled like old books and peppermint which was a welcome scent compared to the reek of old socks and sour milk coming from the rugged looking guy in front of us. He was complaining, to himself, about the noise the bus was making as the seats, poles and doors rattled with the vibrating engine.
I was sitting half way down the bus so that when I leant out into the isle I could see a steady stream of traffic coming from the other direction. Reflected in the rear-view mirror was the bus driver. A rather short and large guy, who looked like he might be in his fifties, and was starting to lose his hair. He wore a checked shirt with a navy blue tie and his eyes were obscured by thick, round glasses that were covered in smudged finger prints. He seemed a jolly kind of guy when I got on the bus and even now he was whistling a jaunty tune and tapping out a rhythm on the steering wheel.
On the other side of the bus isle was a guy in his mid-twenties wearing a white tracksuit, white trainers, lots of gold jewellery and a baseball cap. He was talking loudly and animatedly to someone on the other end of his state-of-the-art mobile phone.
"Don't be a fucking retard!" he exclaimed, which earned him disapproving looks from the older people sitting around him.
At the back of the bus were a group of lads messing around and nicking each other's hats while arguing about who the 'fittest' girl in their year was and who was the most unpopular.
With a shudder and some grinding of the gears the bus was coaxed back into moving with a few "At lasts!" and some "About times!"…….
….. and that moment in time was over.
© Copyright 2017 x Cute Pixie x. All rights reserved.
Status: Finished
Genre: Travel
I quite enjoy when people take the time to soak in what's happening around them in detail :)
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Our MPA is a two year, interdisciplinary, graduate programme in public policy and administration. We prepare students to make an immediate impact for employers by equipping them with world-class formal training as well as applied and professional skills to understand, analyse and produce effective public policy.
In contrast to similar programmes in other policy schools, we put special emphasis on rigorous empirical training, particularly in economics, econometrics and political science. These skills are applied to real world scenarios in the second year of the MPA. Only a two year degree can offer this depth of study and the combination of methodological discipline and practical application.
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Getting started with Intel® Advisor Roofline feature
This document describes the traditional scenario for using the Roofline feature of Intel® Advisor.
Document windows do not reopen when solution is loaded
When a solution is closed, or VS shut down, and the solution is reloaded, or VS restarted, it is supposed to open the document windows that were open when the solution was closed.
ICE C0000005 When compiling Fortran Module with Integer Parameter Statements
When using the 2017 Update 2, I get an ICE C000005 when compiling modules in my code which contain integer parameter statements at the module level and then are used within contained subroutines.
Browse suppliers and find information on purchasing Intel® IoT boards, gateways, accessories, and sensors.
The Circle: a book reportCould you live in a world that doesn't have secrets? Would you want to? The Circle, by Dave Eggers, examines a fictional world that is being nudged toward that end through technology. While reading this book I had many questions about how far society would go or be willing to be led into a place where everything that anyone does or knows can be seen or known by anyone else forever. Some of my...
Intel University Games Showcase GDC 2017Review the schedule and register to attend the Intel University Games Showcase at the Game Developer Conference 2017, featuring the work of student developers.
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text: Hopefully you've heard of this French, anthropomorphic, noir, detective series? (Info Here) Well the fourth album which has yet to be released in America will be released via Dark Horse in July! This is huge news. Furry or no you have to appreciate the absurd attention to detail in the artwork or the intrigue of the story. I'm so excited for this. I read a fan translation but that was garbage. I'm honestly thinking of buying the album twice just to support the series. Blacksad is the best.


text:
Complete our web product in Bootstrap / codeigniter / mysql
This project received 24 bids from talented freelancers with an average bid price of $19 USD / hour.Get free quotes for a project like this
Project Budget$15 - $25 USD / hour
Total Bids24
Project Description
Our inhouse team have been building a sideline project for about a year using codeigniter & bootstrap which has never really been finished because of paying customer work.
It would be great to find someone who can take over and finish the product off , bring it up to date with bootstrap 3 (currently version 2) and get it to a stage of users being able to use it!
To give you an example of its functionality I would suggest you look at [url removed, login to view] , [url removed, login to view] & some of the content marketplaces which allow people to purchasecontent from outsourced providers.
You will need to be able to think for yourself , create nice front end interfaces ( using Bootstrap 3 templates) , and understand CMS products like Wordpress etc.
You will get any help and support you need from our inhouse team when it comes to understanding what we are trying to build but you will need the skills to do it yourself!
Skills Required
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Shape Avoider
by: Robert Lex Coplen • 19
All Android applications categories
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by: Robert Lex Coplen • 19
Avoid enemy shapes in this addicting fast paced action game. Avoid the other shapes as they bounce around the screen or switch modes and go after them.
- Simple but addictive game play allows you to begin playing quickly.
- High scores always saved locally.
- Global high scores available through Scoreloop. Quick easy signup.
- Multiple input modes: touch screen, tilt and virtual touchpad.
- Extra game modes: Attack lets you chase the enemies instead of avoiding them, Practice let's you get used to the controls without worrying about losing the game.
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Every manufacturing company wants to reduce labour costs to improve efficiency, reduce product costs and increase profitability. Mestec helps you achieve this quickly, simply and cost-effectively. We like to let our customers tell the story…
Rapid labour productivity improvement solution
Mestec solutions provide all the information you need to drive continuous labour productivity, factory cost reduction and process improvement programs
"We'd spent two years making improvement in our operations,trying to bring our efficiency levels closer to the target"More »
"Just by communicating individual and group productivity data with operators, we've seen people who were operating at 50% efficiency get up to 70-80%"More »
"We had no way of distinguishing between productive hours and unproductive hours, or knowing if we were spending time rectifying supplier errors."More »
"The identification of non-productive work and unproductive time is very important to us, and we've never previously had the ability to do this."More »
Paperless shop-floor data collection and analytics
Easy and rapid data collection from touch-screen workstations and barcode readers combined with advanced analytics completely eliminates manual processes
"With just paper based system for work content recording, we were finding it difficult to gather data to improve production efficiencies"More »
"We're able to go out there on the factory floor as an issue is actually occurring, and see what is going on, rather than conducting post-mortems afterwards."More »
"We would spend hours entering data into paper forms, copying information into the ERP system, checking records and trying to resolve conflicts and errors"More »
"We can focus 100% on improvement, rather than on data collection and analysis."More »
Off-the-shelf cloud solution with smart dashboards
Our cloud-hosted software solutions integrate seamlessly with your ERP system and provide interactive dashboards that display real-time productivity results
"We had a lot of people being busy, for seven or eight hours a day, but it wasn't clear what value was being added."More »
"Mestec has given our team optimum control of the manufacturing process with operators logging on and off for every manufacturing step"More »
"By the time the production issues were flagged in our ERP system, operators had moved on to other tasks, making problem identification difficult"More »
"The system is very user-friendly, and the operators took to it straight away - even those who were not used to computers"More »
Deploy in as little as 10 days, with no up-front costs
Our specialists work with you on-site to configure the system to match your needs and with our simple payment plan you can be up and running in days
"In a business which had begun its lean manufacturing journey, we had critical gaps in our basic understanding of what was going on"More »
"Overall, we reckon that our investment in Mestec has delivered a three-month payback, as well as helping us deliver a better customer experience"More »
"The trouble was, we had done all the obvious things, and we were still no nearer to finding the answer"More »
"We are on track to reduce our manufacturing costs by 30%"More »
We offer the fastest way to make your factory more productive. Our customers typically see a return of between 5 and 10 times their monthly investment. Try out our ROI Advisor to see how this works for you.
Mestec cloud-hosted solutions are scalable to any size of business, are deployed rapidly by our specialist teams and are available on a simple monthly subscription basis with no up-front costs.


text:
KANSAS CITY, Mo. -- For four pitches, it appeared Matt Harrison's All-Star debut was going to be a good one. He retired the first two batters he faced -- Pablo Sandoval and Dan Uggla -- and was hoping to get Rafael Furcal and get back to the dugout.
But Furcal hit what Harrison said was a good pitch (closer Joe Nathan agreed, saying it was down and on the black of the plate) for a triple to right field. Pinch hitter Matt Holliday then singled the other way to score Furcal. Then Harrison made a big mistake to Melky Cabrera.
"That pitch was right down the middle and he hit a homer," Harrison said.
Cabrera was named the MVP of the game.
Harrison was disappointed he didn't pitch better, but he was pleased to play in the All-Star Game.
"They got to me, but I wouldn't trade this experience for anything," Harrison said. "It was a great time and I will definitely cherish this moment for a long time.
"This is the All-Star Game. It was my first time here. I gave up a couple of runs, but that's just the way it goes."


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Gremolata Vegetables And Wholewheat Pasta
|Thin whole wheat noodles/Spaghetti
|6 Ounce (185 Grams)
|Chopped parsley
|2 Tablespoon
|Finely grated lemon rind
|1 Tablespoon
|Finely chopped garlic
|1 Teaspoon
|Olive oil
|2 Tablespoon
|2 Ounce, softened (60 Grams)
|Cheese curd
|8 Ounce (250 Grams)
|Soured cream
|1⁄4 Pint (150 Milliliter)
|1 1⁄2 Pound, grated (150 Grams)
Cook the pasta in a large pan in masses of boiling salted water; drain, and toss in the parsley, lemon rind, garlic and olive oil.
Make a sauce by mixing the butter, cheese and the eggs with 2 tablespoons of the soured cream.
In a souffle dish, layer the noodles and grated vegetables, pouring on the sauce as you go.
Press gently to ensure the sauce is distributed evenly.
Cover with the remaining soured cream, and sprinkle with a sharp cheese if you like, but this is not essential.
Put in the oven and bake at 190°C/375°F/Gas Mark 5 for 20 minutes.
Allow the dish to settle for 10 minutes; it will not set firmly but can be cut neatly even when warm.
Served with a salad and perhaps a baked potato, you will have a spectacularly good meal.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 585 Calories from Fat 300
% Daily Value*
Total Fat 34 g52.4%
Saturated Fat 15 g74.9%
Trans Fat 0 g
Cholesterol 257.9 mg86%
Sodium 209.6 mg8.7%
Total Carbohydrates 56 g18.8%
Dietary Fiber 11.2 g44.9%
Sugars 3.1 g
Protein 19 g37.6%
Vitamin A 200.1% Vitamin C 55.3%
Calcium 16.5% Iron 20.4%
*Based on a 2000 Calorie diet


text:
July 31 2014 Thursday at 01:49 PM
New Sublime Floss Palette!
There's a NEW Sublime Floss Palette! Christmas Tree will get you in the holiday mood, even during the middle of summer. Hey- it's not too soon to start stitching your ambitious holiday gifts! And, I'm super excited that this palette includes two, smoooooth-stitching metallics! And yes, dear: it's now included in the Sublime Floss ALL PALETTES Sampler -and I didn't even raise the price. Call me Santa's L'il Helper.


text:
Smoking remains the leading preventable cause of death, accounting for one-third of all cancers and nearly two-thirds of heart disease among people under 55. Reducing tobacco-induced disease requires understanding how its vector, the tobacco industry, maintains a social and policy environment favorable to smoking. To understand a microbe, one might study its genome;the tobacco industry's "genome" is its written record of research and decision making in the form of over 51 million pages of previously secret internal tobacco industry documents. This application extends our current work to address tobacco industry influence on science and policy making in the emerging US and global regulatory environment, and to learn from the industry's promotional strategies targeting young adults and women to develop improved counter-measures.
Specific aims are: (1) Describe and assess the tobacco industry's evolving strategies to influence the conduct, interpretation, and dissemination of science and how the industry has used these strategies to oppose tobacco control policies, with particular emphasis on how these efforts relate to emerging national and international product regulations by the US Food and Drug Administration and its counterparts in other countries. (2) Analyze evolving tobacco industry strategies to oppose tobacco control policies at the local, state, and international level, including efforts to undermine implementation of the World Health Organization Framework Convention on Tobacco Control. (3) Analyze tobacco marketing and advertising strategies aimed at young adults and women, with an emphasis on identifying principles that can be applied to develop more effective tobacco prevention and cessation strategies for these groups. (4) Continue to locate and collect tobacco industry documents relevant to the other Aims of this project and make them freely available to other investigators and the public via the Internet. While this research makes systematic use of digitized tobacco industry documents as a data source, we will also triangulate with other sources (including government records, media coverage of issues discussed in the documents, the academic literature and interviews with key informants) to confirm whether plans described in the documents were actually implemented and to assess their effect. Results of this research will guide the development of more informed and effective tobacco control strategies which will help reduce tobacco use and its associated burden of disease and death.
Smoking is the leading preventable cause of death, accounting for 1/3 of all cancers and nearly 2/3 of heart disease among people under 55. Reducing this burden of disease requires understanding how the tobacco industry maintains a favorable social and policy environment to promote smoking so that public health professionals can develop and implement effective programs to prevent smoking and promote cessation.
|Velicer, Clayton; Lempert, Lauren K; Glantz, Stanton (2015) Cigarette company trade secrets are not secret: an analysis of reverse engineering reports in internal tobacco industry documents released as a result of litigation. Tob Control 24:469-80
|Fallin, Amanda; Grana, Rachel; Glantz, Stanton A (2014) 'To quarterback behind the scenes, third-party efforts': the tobacco industry and the Tea Party. Tob Control 23:322-31
|Jiang, Nan; Lee, Youn Ok; Ling, Pamela M (2014) Association between tobacco and alcohol use among young adult bar patrons: a cross-sectional study in three cities. BMC Public Health 14:500
|Crosbie, Eric; Gonzalez, Mariaelena; Glantz, Stanton A (2014) Health preemption behind closed doors: trade agreements and fast-track authority. Am J Public Health 104:e7-e13
|Laposata, Elizabeth; Kennedy, Allison P; Glantz, Stanton A (2014) When tobacco targets direct democracy. J Health Polit Policy Law 39:537-64
|Barry, Rachel Ann; Hiilamo, Heikki; Glantz, Stanton A (2014) Waiting for the opportune moment: the tobacco industry and marijuana legalization. Milbank Q 92:207-42
|Brown-Johnson, Cati G; England, Lucinda J; Glantz, Stanton A et al. (2014) Tobacco industry marketing to low socioeconomic status women in the U.S.A. Tob Control 23:e139-46
|Ling, Pamela M; Lee, Youn Ok; Hong, Juliette et al. (2014) Social branding to decrease smoking among young adults in bars. Am J Public Health 104:751-60
|Song, Anna V; Brown, Paul; Glantz, Stanton A (2014) When health policy and empirical evidence collide: the case of cigarette package warning labels and economic consumer surplus. Am J Public Health 104:e42-51
|Lee, Youn Ok; Bahreinifar, Sareh; Ling, Pamela M (2014) Understanding tobacco-related attitudes among college and noncollege young adult hookah and cigarette users. J Am Coll Health 62:10-8
Showing the most recent 10 out of 125 publications


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Definitions for unbiased
This page provides all possible meanings and translations of the word unbiased
Princeton's WordNet
indifferent, unbiased, unbiassed(adj)
characterized by a lack of partiality
"a properly indifferent jury"; "an unbiasgoted account of her family problems"
unbiased, unbiassed(adj)
without bias
impartial or without bias or prejudice
Webster Dictionary
free from bias or prejudice; unprejudiced; impartial
Chaldean Numerology
The numerical value of unbiased in Chaldean Numerology is: 9
Pythagorean Numerology
The numerical value of unbiased in Pythagorean Numerology is: 3
Sample Sentences & Example Usage
This ranking attempts to be completely unbiased when looking at the outcomes when everyone is on the same playing field.
It is only about things that do not interest one that one can give really unbiased opinions, which is no doubt the reason why an unbiased opinion is always valueless.
My appeal board consisted of one very flamboyant male teacher and the head of the inclusiveness and diversity department, it wasn't a very unbiased board at all that heard my case.
Not every community has access to a lactation consultant, and while talking to friends and family can be good, they are anecdotal, [Moms] want to hear an unbiased, professional opinion.
Love is a symbol of mutual tolerance and unbiased vision. We should meet each person with love and respect, regardless of nationality, color, or religion. Permeated by love, no one takes up arms, to kill others.
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text:
Number Two Home
The Japanese in Western Australia before 1942
By (author) Noreen Jones
Format: Paperback
Normal Price: $24.95
Your Price: $22.46 AUD, inc. GST
Shipping: $7.95 per order
You Save: $2.50! (10% off normal price)
Plus...earn $1.12 in Boomerang Bucks
Availability: Available, ships in 7-10 days
Number Two Home by Noreen Jones
Book DescriptionNo Marketing Blurb
Buy Number Two Home book by Noreen Jones from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9781863683685
(208mm x 149mm x 13mm)
Pages: 224
Imprint: Fremantle Arts Centre Press
Publisher: Fremantle Press
Publish Date: 3-Jun-2002
Country of Publication: Australia
Books By Author Noreen Jones
North to Matsumae, Paperback (April 2008)» View all books by Noreen Jones
Retraces the perilous voyages of two nineteenth-century Australian whaling ships, the Lady Rowena and the Eamont, as they endured shipwreck, mutiny, massacre and imprisonment while harvesting whales off the Japanese coast. This title draws on the journal of the Lady Rowenas ship master and is supplemented by Japanese historical accounts.
» Have you read this book? We'd like to know what you think about it - write a review about Number Two Home book by Noreen Jones and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Noreen Jones
Authors Bio, not available
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With the purchase of Kobo VIP Membership, you're getting 10% off and 2x Kobo Super Points on eligible items.
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A Dog's Purpose—the #1 New York Times bestseller—is heading to the big screen!
Heartwarming, insightful, and often laugh-out-loud funny, A Dog's Purpose is not only the emotional and hilarious story of a dog's many lives, but also a dog's-eye commentary on human relationships and the unbreakable bonds between man and man's best friend. This moving and beautifully crafted story teaches us that love never dies, that our true friends are always with us, and that every creature on earth is born with a purpose.
Dereliction Of Duty is a stunning new analysis of how and why the United States became involved in an all-out and disastrous war in Southeast Asia. Fully and convincingly researched, based on recently released transcripts and personal accounts of crucial meetings, confrontations and decisions, it is the only book that fully re-creates what happened and why. It also pinpoints the policies and decisions that got the United States into the morass and reveals who made these decisions and the motives behind them, disproving the published theories of other historians and excuses of the participants...
With generosity of spirit, ebullience, and sly humor, Mary Tyler Moore presents the intensely private, often funny, and sometimes startling story of her life with diabetes. Growing Up Again is a delightfully candid read for her legion of fans, the more than 20 million Americans with diabetes, and everyone struggling to cope with life's unexpected challenges.
The long-awaited first novel from the author of Tenth of December: a moving and original father-son story featuring none other than Abraham Lincoln, as well as an unforgettable cast of supporting characters, living and dead, historical and invented
February 1862. The Civil War is less than one year old. The fighting has begun in earnest, and the nation has begun to realize it is in for a long, bloody struggle...


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- 08-19-2014, 04:43 PM Thread Author #1
Music transfer
How can I transfer songs from my Amazon cloud to my android device?
- 08-19-2014, 05:17 PM #2Retired Ambassador
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Re: Music transfer
Do you have the amazon cloud/streaming service on your device? If so, there might be an option to pin or download the music there.
If there isn't you'll have to either go to their site and see if you can download from there.
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text:
please this is sent to me by a Doctor, I did not have anything to do with it… DOCTORS
(A) The number of physicians in the U.S. is
(B) Accidental deaths caused by Physicians
per year are
(C) Accidental deaths per physician
Statistics courtesy of U.S. Dept of
Health Human Services.
Now think about this:
(A) The number of gun owners in the U.S.
(Yes, that's 80 million)
(B) The number of accidental gun deaths
per year, all age groups,
(C) The number of accidental deaths
per gun owner
Statistics courtesy of FBI
So, statistically, doctors are approximately
9,000 times more dangerous than gun owners.
Remember, 'Guns don't kill people, doctors do.'
Please alert your friends
to thisalarming threat.
We must ban doctors
before this gets completely out of hand.
Out of concern for the public at large,
I withheld the statistics on
for fear the shock would cause
people to panic and seek medical attention.
It kind of makes you wonder what people learn in school in other countries. I don't think I was ever that ignorant about any country that i ever studied in school, or even heard of to that matter. Because Everyone In CanadaLives In An Igloo. Now that Vancouverhas won the chance to host the 2010 Winter Olympics, these are some questions people from all over the world are asking. Believe it or not these questions about Canadawere posted on an International Tourism Website. Obviously the answers are a joke; but the questions were really asked! Q: I have never seen it warm on Canadian TV, so how do the plants grow?(England)A: We import all plants fully grown and then just sit around and watch them die. Q: Will I be able to see Polar Bears in the street? (USA)A: Depends on how much you've been drinking. Q: I want to walk from Vancouverto Toronto- can I follow the Railroad tracks? (Sweden)A: Sure, it's only Four thousand miles, take lots of water. Q: Is it safe to run around in the bushes in Canada? (Sweden)A: So it's true what they say about Swedes. Q: Are there any ATM's (cash machines) in Canada? Can you send me a list of them in Toronto, Vancouver, Edmontonand Halifax? (England)A: What, did your last slave die? Q: Can you give me some information about hippo racing in Canada? (USA)A: A-fri-ca is the big triangle shaped continent south of Europe. Ca-na-da is that big country to your North… oh forget it. Sure, the hippo racing is every Tuesday night in Calgary. Come naked. Q: Which direction is North in Canada? (USA)A: Face south and then turn 180 degrees Contact us when you get here and we'll send the rest of the directions. Q: Can I bring cutlery into Canada? (England)A: Why? Just use your fingers like we do. Q: Can you send me the Vienna Boys' Choir schedule? (USA)A: Aus-tri-a is that quaint little country bordering Ger-man-y, which is… oh forget it. Sure, the Vienna Boys Choir plays every Tuesday night in Vancouverand in Calgary, straight after the hippo races. Come naked. Q: Do you have perfume in Canada? (Germany)A: No, WE don't stink. Q: I have developed a new product that is the fountain of youth. Where can I sell it in Canada? (USA)A: Anywhere significant numbers of Americans gather. Q: Can you tell me the regions in British Columbiawhere the female population is smaller than the male population? ( Italy)A: Yes, gay nightclubs. Q: Do you celebrate Thanksgiving in Canada? (USA)A: Only at Thanksgiving. Q: Are there supermarkets in Torontoand is milk available all year round? (Germany)A: No, we are a peaceful civilization of Vegan hunter/gathers. Milk is illegal. Q: I have a question about a famous animal in Canada, but I forget its name. It's a kind of big horse with horns. (USA)A: It's called a Moose. They are tall and very violent, eating the brains of anyone walking close to them. You can scare them off by spraying yourself with human urine before you go out walking. Q: Will I be able to speak English most places I go? (USA)A: Yes, but you will have to learn it first.


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Fix Broken PS3 Controller
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Mea Culpa: We're Sorry Danny Brown
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A few useful ideas for making and understanding things.
A little comparison between Elixir and Javascript.
Recipe #1: a great way to get your caffeine hit over the summer
An overview of various (side) projects both large and small.
How I made a game in few hours on an iPad (and came 5th in a Gamejam). With an introduction to Codea and Lua.
My take on cross platform frameworks in 2014.
Some counterinuitive tips on Programming
My Android Privacy Policy.
Some tips on agent based modelling.
For web projects just use Bootstrap 3 (unless you want to increase billable hours).
Why I don't think it is worth supporting Android < 4.0 or iOS < 7 on new Apps.
My plan to make time better.
Some tips on using Pandas, a Python data library built on Numpy.
The details for my lightening talk on really easy and quick 3d realtime interactive graphics.
In no particular order, some of the key things I consider when selecting a programming language or technical tool.
Additional academic details, not included in my regular CV.
Some tips on creating Web Apps for iOS, Firefox OS and Chrome.
A collection of my favourite quotes.
Some books I highly recommend which you may have overlooked.
A few jokes about economics, starting with my favourite.
Since doing a half-CS (half-Maths) degree I've done quite a bit of work with software. I've lost count of the number of languages I've used.
Facts, numbers, ideas, big, small, medium data. Open government, statistics and understanding. Machine learning and data mining.
Creation. Beauty. Aesthetics. Design. Form. Display. Arrangement. And some projects I have taken part in. Other pretentious things.
Thoughts and ideas on a range of subjects. A miscellaneous section.
An overview of various (side) projects both large and small.
I've recently done something substantial with...
These international websites have endorsed some of my work...
I've done something non-trivial with or am learning...


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Four-photo panorama taken with a Nikon D7100 and a Tamron 17-55 f/2.8 lens. Another view from several years ago: gigapan.com/gigapans/18326
This panorama (13x2) was taken with the same lens but on a Nikon D-70 (13x2): gigapan.com/gigapans/34909 A GigaPan taken the same time can be seen via this link: gigapan.com/gigapans/177810 and is a 10x3 panorama taken with a Nikon D-7100 and a Nikkor 105mm f/2.8. riceu
I travelled to Rice today in order to resume taking GigaPans once again since I now have a very nice camera, Nikon D-750, and it appears that the kit lens, Nikkor 24-120mm f/4 is more than adequate for my purposes. For thise that have seen my GigaPans before, Herzstein Hall has been seen numerous times, especially t...
I really have to compliment the GigaPan Stitcher for this stitch ... amazing considering what was handed to it! When I loaded the 40 photos into the Stitcher, all I saw was mis-match, and was most surprised to see an almost error free stitch. This GigaPan complements the very first GigaPan I ever took: gigap ...
Amazing sunlight for a late February afternoon, and it appears that I was the only one to enjoy this visual; however, there were a number of Owls studying away in Fondren. This was only a test: the aperature was fixed at f/9, ISO set at 800 and unusual for me, the shutter speed varied. Getting ready for Paris :)
Initial center of attention was to be the north-east corner of the Acedemic Quad; however, the student laying on the grass, perhaps, is trying to recover from the Holidays, or else trying to recover from the suffocating amout of homework he has had thrust upon him.
We first encountered the orange ladder in the Academic Quad, thinking it was a ladder to success ( gigapan.com/gigapans/115854 ); however, it was only the ladder to the sound system. I took 15 photos with my iPhone 4S and stitched them with the GigaPan Stitcher. This view is good when seen via the Google E...
This panorama is of Dr. Robert Patten (Lynette S. Autrey Professor in Humanities), the paper presenters and participants of a wonderful two-day program to honor Dr. Patten upon his recent retirement from Rice University. Actually, he has returned to Rice from spending the academic year 2011-12 as first Scholar in R...
Prior to the Rice University Centennial Celebration, I found this lady, who cheerfully posed for me. For her kindness, I wish her great success. Stitched panorama comprised of 25 photos, taken with a Nikon D7000 and a Nikkor 35mm f/1.8 lens. As always, the view via the Google Earth link can be spectacular.
A beautiufl day to take photos and this area was flooded in sunlight.


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Requirements for PSGA applicants are:
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The central premise of this proposal is that the lens has evolved several key protective and repair systems that maintain its transparent function and that an age-related decrease in the function of these systems contributes to age-related cataract. A hallmark of human lens aging and cataract formation is oxidation of protein methionines to protein methionine sulfoxide (PMSO). PMSO levels increase in the human lens with age and in human age-related cataract, 60% of total lens protein is found as PMSO. PMSO causes loss of protein function, protein aggregation and cell death. However, to date, the role of PMSO in lens aging and cataract formation has not been established. One key to unlocking the role of PMSO in lens aging and cataract formation is to identify those repair mechanisms that the lens has evolved to defend against PMSO damage and those proteins whose functions are lost upon methionine sulfoxide (MSO) formation. We have discovered that a novel PMSO repair enzyme called methionine sulfoxide reductase A (MsrA) is essential for lens defense against oxidative stress, viability, and defense against cataract formation. Since PMSO accumulates in the human lens with increasing age and since MsrA activity is essential for cataract resistance, it is likely that loss of MsrA repair of one or more lens proteins oxidized to PMSO upon aging and/or oxidative stress contributes to loss of protein function and cataract. A likely target for MsrA repair is ?-crystallin, which exists in the lens as an oligomer of two subunits (? A and ? B) each containing two conserved methionines. In addition to its role as a structural lens crystallin, ? -crystallin is essential for lens function through its ability to act as a molecular chaperone that protects lens proteins against age-related damage. This application will test the hypothesis that oxidation of ? -crystallin to methionine sulfoxide (? -crystallin-MSO) causes loss of chaperone function and that MsrA can repair and restore the chaperone function of ? -crystallin-MSO. Thus, loss of MsrA activity upon aging could result in increased levels of ? -crystallin-MSO, loss of lens chaperone function and ultimately cataract formation. The results of these studies will provide a novel mechanism for cataract development and an innovative model describing the interdependent functions of key lens protective and repair systems. The information gained from this work could have a major impact on the rational design of therapeutics based on increasing the activity of MsrA thereby preventing cataract formation.
The lens has evolved several key protective and repair systems that maintain its transparent function and an age-related decrease in the function of these systems contributes to age-related cataract the leading cause of visual impairment world-wide. The information gained from this work will have a major impact on the rational design of therapeutics that could prevent cataract formation.
|Chauss, Daniel; Basu, Subhasree; Rajakaruna, Suren et al. (2014) Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. G3 (Bethesda) 4:1515-27
|Costello, M Joseph; Brennan, Lisa A; Basu, Subhasree et al. (2013) Autophagy and mitophagy participate in ocular lens organelle degradation. Exp Eye Res 116:141-50
|McGreal, Rebecca S; Brennan, Lisa A; Kantorow, Wanda Lee et al. (2013) Chaperone-independent mitochondrial translocation and protection by ?B-crystallin in RPE cells. Exp Eye Res 110:10-7
|McGreal, Rebecca S; Kantorow, Wanda Lee; Chauss, Daniel C et al. (2012) *B-crystallin/sHSP protects cytochrome c and mitochondrial function against oxidative stress in lens and retinal cells. Biochim Biophys Acta 1820:921-30
|Kantorow, Marc; Lee, Wanda; Chauss, Daniel (2012) Focus on Molecules: methionine sulfoxide reductase A. Exp Eye Res 100:110-1
|Chen, Jianjun; Ma, Zhiwei; Jiao, Xiaodong et al. (2011) Mutations in FYCO1 cause autosomal-recessive congenital cataracts. Am J Hum Genet 88:827-38
|Yang, Chunbo; Yang, Ying; Brennan, Lisa et al. (2010) Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions. FASEB J 24:3274-83
|Brennan, Lisa A; Lee, Wanda; Kantorow, Marc (2010) TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of ?-crystallin and cytochrome C in the eye lens. PLoS One 5:e15421
|Brennan, Lisa A; Kantorow, Marc (2009) Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations. Exp Eye Res 88:195-203
|Brennan, L A; Lee, W; Cowell, T et al. (2009) Deletion of mouse MsrA results in HBO-induced cataract: MsrA repairs mitochondrial cytochrome c. Mol Vis 15:985-99
Showing the most recent 10 out of 33 publications


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Lot 19: Mick Moon, Threshold, Mixed Media Collage Painting
October Fine Art Auction
by RoGallery
20 October 2016
Long Island City , NY, USALive Auction
Mick Moon (1937-) Please Register/Login to access your Invaluable Alerts
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Artist: Mick Moon, British (1937 - )
Title: Threshold
Year: 1986
Medium: Mixed Media Collage on Canvas, signed and dated
Size: 63 x 82 in. (160.02 x 208.28 cm)
Frame Size: 70 x 90 inches
Artist or Maker: Mick Moon
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The most recent surveys could finally be proof of what homeowners have been dreading and first-time buyers praying for.
Both the Halifax bank and the Royal Institution of Chartered Surveyors say house prices are falling – not by much but falling all the same. Meanwhile, Nationwide building society says prices rose slightly last month but well below the trend of recent months. What's more, surveyors report fewer enquiries from potential buyers, and mortgage firms are seeing fewer applications from new purchasers in the wake of the Northern Rock crisis. The signs are that the UK housing market – after years of spectacular growth – is finally on the turn.
The doomsayers are adamant. Jonathan Davis at website Housepricecrash says: "Any monthly rises still continuing are misleading, as they are largely derived from independent bubbles that distort the figures."
In particular, he points to property prices in Northern Ireland, which he believes have distorted the overall UK statistics. Partly thanks to the peace dividend, average prices in the province have risen by an unprecedented 42.6 per cent in the past year, according to Nationwide. This boom has been especially stark in Belfast, where increases over the past year stand at 50 per cent, taking the price of the average property in the city to a whopping £312,637.
Mr Davis's prediction for the UK is bleak: a fall of 30 to 40 per cent over the next four to six years. He adds that while the recent credit crunch may yield one more rate cut, the cost of borrowing will be higher than it is now by 2009. This combination, he believes, could lead to up to a million homes being repossessed.
But such doom and gloom is out of kilter with the views of other industry observers. "We are certainly undergoing a big slowdown in the housing market and prices are flatlining, but you need to get beyond national prices to obtain an accurate picture," says Ray Boulger at mortgage broker John Charcol. "While some areas will see falls of 5 per cent, others will continue to rise by 10 per cent."
Martin Ellis, chief economist at the Halifax, says: "The UK economy is in a strong position. Sound market fundamentals, including high levels of employment and a shortage of properties available for sale, will continue to support house prices."
By contrast, Mr Davis claims that after more than 10 years of buoyancy, the economy is now standing on a precipice. "The only reason a market crash is not already well under way is that the Bank of England irresponsibly reduced interest rates by a quarter point to 4.5 per cent back in August 2005. And so, despite five rises since, positive sentiment has continued."
But for each overstretched homeowner, there are surely several more first-time buyers raring to seize the day when they are able to get on the first rung of the ladder. James Cotton, mortgage manager at broker London & Country, says of the slowdown: "It could mean first-timers get a breather during which they have time to put a deposit together. This has not been the case to date as house prices have been increasing faster than buyers are able to save. Flattening prices may also result in a switch to a buyers' market where first-timers have room to negotiate on price."
But the kind of decline forecast by Mr Davis is what it would take to make a real difference, says Helen Adams at the website First- RungNow. "A price drop of at least 20 per cent would be needed before any critical mass could be gained. And remember that while cheaper property would make houses and flats more affordable to first-time buyers, landlord-investors would also enter the market. I don't think property prices would stay low for very long even if there was a significant price drop."
But Mr Davis says some 250,000 landlords will have had their homes repossessed by 2009 anyway. "Be warned – the next few years are not going to be pretty."
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Tuesday, February 28, 2017
Simpsons 'Treehouse' Goes Interactive
The trick-or-treaters may have retreated to their lairs to count their candy, but Halloween is never officially over until Fox airs the beloved annual 'Treehouse of Horror' ... Continue Reading →
Going Where No Machinima Has Gone Before
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MGM Puts Panther on iTunes
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Comedy Central Grows a Pair
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Comedy Central Makes Friends with Test Pilot
Comedy Central has named Wade Randolph's animated series Awesome Friends the first winner of its user-generated content contest dubbed 'Test Pilots.' The quirky toon ... Continue Reading →
JibJab, Landis Experiment with Sketch
JibJab, the digital comedy network behind such popular viral web toons as the political satires This Land and Good to be in DC! has teamed with Verizon Wireless and accomplished film ... Continue Reading →
Family Guy's Brian Goes Blogging
Family Guy fans can now go online to check out some nuggets of wisdom from the Griffin's martini-sipping family dog, Brian. The character is featured as a guest blogger on familyguy.com ... Continue Reading →
DreamWorks Launches First Flight Site
DreamWorks Animation has announced that the official website for its award-winning short film First Flight has gone live at www.firstflightshort.com. Visitors to the site can learn ... Continue Reading →
NBC Expands Late Night Toon
Avid viewers of NBC's Late Night with Conan O'Brien will recall Pale Force, a series of animated shorts introduced by comedian Jim Gaffigan, a regular guest on the talk ... Continue Reading →
Fans Making the Videos on Habbo
Members of Habbo, one of the world's largest online social networks for teens, are making their own animated music videos for Universal Def Jam recording artist Lady Sovereign ... Continue Reading →