text: Kylie Jenner Can't Remember Ever Not Being Incredibly FamousLindy West11/14/13 8:00pmFiled to: dirt bagkylie jennergwyneth paltrowmoses paltrowapple paltrowhilaria baldwin1212EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Kylie Jenner revealed that she can't remember a time when she wasn't famous. It's a statement that I fully believe to be true, but it does make me wonder...which one is Kylie Jenner again? Advertisement "I don't remember how it was before [I was famous] because I was nine when this all started," Jenner told UsWeekly during the opening of Sugar Factory in Hollywood, Calif. on Wednesday night."So it's kind of like I grew up into it. It's kind of like I don't know any different."As Radar reported on Tuesday, Bruce and Kris Jenner's daughter admitted that while being homeschooled she only does "three or four hours" of education per day — as opposed to the usual public school attending student who does seven or eight."[Then] I usually work. I'm pretty busy all day," Jenner said.And the Keeping Up With The Kardashians star has no plans of slowing down."[Maybe] try acting or something. I have no clue," she said of future endeavors.K! [Radar] Hilaria Baldwin gave an interview about what it was like to testify against her husband's stalker. Advertisement "We're going to sleep well for the next 210 days. Now that it is finally over, I feel safe, relieved, and happy to move forward."The yoga instructor, who testified Monday with husband Alec, said it was scary to have to face Sabourin in court. "I was shaking the entire time, but I was grateful for the officers of the court who would step in front of me and ask her to be quiet, along with the judge and her lawyer who were asking her to be quiet."Hilaria continued, "She said I was going to go to hell. She said that my baby isn't real. Every single time I made a comment, she would tsk me, move her chair, sigh heavily."As for the allegations Sabourin made against the "30 Rock" star, Hilaria explained, "I never questioned that he was faithful. I remember from the first couple of dates that we had, he told me that there was this woman who was stalking him. He showed me proof. I didn't even know him when he took her out as a favor to a friend."0__________o [Extra] GIF Here's what Apple and Moses Paltrow want for Christmas. Advertisement Sponsored So what's little Moses hoping is under the tree on Christmas morning?"Skylanders Swat Force, acoustic guitar, hamster. And, pretty much everyone wants a rainbow loom," the 7-year-old shared.And Apple?"I want an iPod 5, a Lifeproof case for my iPod5 so I can take it underwater and a Kipling rolley backpack," she revealed.PRETTY MUCH EVERYONE WANTS A RAINBOW LOOM. [E!]Here is Jean-Claude Van Damme doing the splits. [E!]Peter Dinklage went shopping. [DailyMail]Khloe and Lamar are in couples therapy. [Extra]Sam Claflin and Josh Hutcherson have a "beautiful relationship." [MTV]Harry Connick Jr. tweeted some sassy emojis at Mariah Carey. [Us]Lohan Instagrammed a photo of herself topless and I think we're supposed to be dicks about it or something (?), but she looks great. [HuffPo]Jake Gyllenhaal fucked up his hand and had to get stitches. [CBS]J-Hud and Charlize wore the same dress, so they fought to death in the Octagon. [E!]Chris Brown is out of rehab. [ContactMusic]Reply121 repliesLeave a reply


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Watkins: Jones should extend Garrett now
Discussion in 'Fan Zone' started by Nirvana, Jan 16, 2014.
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Skip to comments.Republicans, 2016: In full swing (At least 15 Republicans privately contemplating 2016 campaign)
Posted on 11/21/2012 7:36:46 AM PST by SeekAndFind
Tired of presidential politics? Get over it: Upwards of 15 prominent Republicans are privately contemplating 2016 campaigns for the presidency and the most serious and ambitious of the bunch are already plunging in, some quite publicly.
Dont expect them to officially announce or even officially decide for many months. But Sen. Marco Rubio (R-Fla.), Louisiana Gov. Bobby Jindal and House Budget Chairman Paul Ryan (R-Wis.) are doing nothing to disguise their presidential ambitions.
Jindal, the Rhodes scholar and new chairman of the Republican Governors Association, is making a very public case for a more intellectual approach to conservatism, accusing the GOP of being, in his words, the stupid party.
He offered a similar premeditated critique to reporters at the RGA, on Fox and in an opinion piece.
Rubio and Ryan, both arguably better positioned than Jindal, are also competing for the mantle of the high-energy, forward-thinking conservative. POLITICO has learned both will unveil new policy plans at an awards dinner of the Jack Kemp Foundation in early December: Ryan will begin a new push on a more modern approach to alleviating poverty, focused on education; Rubio will lift the curtain on an economic empowerment message, heavy on college affordability and workforce training.
That upcoming duet is one of the clearest signs that this presidential race is beginning as early as any in history.
Not to be outdone, Sen. Rand Paul (R-Ky.), son of Rep. Ron Paul (R-Texas) and heir to his fathers libertarian following, is now on the record exploring a run that will focus heavily on returning power to the states. In a post-election interview with POLITICO, Paul said he wants to find common ground with liberal Democrats on softer marijuana laws and help create an eventual pathway to citizenship for undocumented immigrants.
These 40-something rising stars are hardly alone. New Jersey Gov. Chris Christie, despite party grumbling about his embrace of President Barack Obama during the recent hurricane, has made plain that he plans to make the case that he has cracked the code on winning on Democratic turf. Christie has the perfect chance to take the temperature of big donors as he raises money for his 2013 reelection race for governor. He will do just that, friends say.
POLITICO has also learned that Rick Santorum is telling friends he wants to run again. Texas Gov. Rick Perry has said publicly that he might, too, and has begun talking to donors and other top supporters like he means it. And Jeb Bush, the former Florida governor with strong credentials on education and winning back Hispanics, has told advisers he will sit back to see how things unfold over the next year before deciding whether to finally give it a go.
Jeb Bush Jr., the former governors younger son, said Tuesday when asked on CNNs Starting Point whether his father would run: I certainly hope so.
You have this young crop, of attractive, successful, proven problem-solvers, former Mississippi Gov. Haley Barbour said. Old guys like me have to get out of the way. Barbour said the way to stand out in the field will be to help with the partys 2013 and 2014 races. Were not going to wait till 2016 to set a strong new course, he added.
This all might seem premature and a possible big-time distraction for a party that lost the presidency and Senate and House seats this time around. But top Republican officials are encouraging the never-ending presidential campaign in hopes of creating influential national voices beyond Fox News and Rush Limbaugh. On every conference call, the message is the same, one top official said. Were going to push out our new generation of leadership. Were not going to sit back and let the extreme voices define what it means to be a conservative.
Republicans are still haunted by the post-election chaos of 2008, when, with John McCain diminished by defeat and few clear future leaders with national juice on the scene, Limbaugh, Glenn Beck and Sarah Palin filled the void and dominated news coverage. This time feels different: Unlike 2008, when Republicans chalked up their defeat to a bad GOP ticket in a terrible post-Bush environment for the party, many of the most influential voices are calling for substantial rethinking of the conservative approach to politics. They are reckoning with demographic trends that favor Democrats as well as with exit polling suggesting the assumption this is a center-right country might be wrong, or was at least wrong on Nov. 6, when a center-left electorate showed up.
The danger, of course, is that Republicans get pulled into a bitter fight over the direction of the party, especially as more traditional and hard-edged conservatives jump into the race.
Republican sources said Rep. Michele Bachmann (R-Minn.) might want to fill the void on the religious right now and that Mike Pence, who just won the gubernatorial race in Indiana, has expressed interest in running, too.
Wisconsin Gov. Scott Walker, who unlike Ryan won statewide in a state Obama won twice, also harbors national ambitions and remains a favorite of tea party conservatives.
For now, most of the media attention is on Republicans who can help the party adapt to the changing demographics, weeks after the party lost African-Americans by 90 points, Asian-Americas by 50 points, Hispanics by more than 40 points and women by just over 10. This will put a lot of emphasis on the small minority of minority leaders inside the GOP. Condoleezza Rice, one of the few stars of this summers Republican convention in Tampa, has told Republicans she will continue speaking out on the future of the party, which will fuel 2016 speculation. A Rice runs strikes many Republicans as unlikely, given her previous resistance.
Others known to be openly thinking about a run include New Hampshire Sen. Kelly Ayotte; two Western governors who are Hispanic, Susana Martinez of New Mexico and Brian Sandoval of Nevada; and South Carolina Gov. Nikki Haley.
Finally, there are the elected officials who are perpetually looking for something bigger: Sens. John Thune of South Dakota and Rob Portman of Ohio; Virginia Gov. Bob McDonnell, whose term ends in 2014; and Ohio Gov. John Kasich, who like so many others on this list has made his ambitions known in private conversations with donors and activists.
Republican National Committee Chair Reince Priebus said in an email to POLITICO: While the RNC engages in a serious post-election analysis of what worked well and what needs to be improved upon, one area that gives me great optimism is the caliber and quantity of potential 2016 candidates on the GOP side. The top names on the GOP side are talking about serious solutions and reforms to the major issues facing the country which will put the Republican field in a solid position.
With all this activity, Jindal, Rubio and Ryan know there is little time to waste in trying to position themselves to be the one, the candidate who can lead the party back with conservative thinking calibrated to appeal to a changing America. Jindal has been the most aggressive, hitting his party hard in his post-election interview with POLITICO, posting an op-ed on CNN and offering a sharp critique of his party during last weeks RGA meetings. In the interview, Jindal urged an end to dumbed-down conservatism. We need to stop being simplistic. Weve got to make sure that we are not the party of big business, big banks, big Wall Street bailouts, big corporate loopholes, big anything, he said.
Ryan allies believe that although his vice presidential run ended in a disappointing rout (with Obama winning his home state of Wisconsin), he has more celebrity, credibility and clout after the race. With his expertise and power in the upcoming budget fights, Ryan will be a central figure in the policy and political debates of 2013.
Rubio plays up his working-class roots and values as part of an appeal to voters making $30,000 to $50,000 a year a group Romney lost badly but with whom Republicans used to be very competitive. That, combined with his connection with Hispanic voters, would make him a bit of an anti-Romney the one card nearly every one of these candidates will try to play, however subtly. Rubio planted the flag in Iowa last weekend, setting a record at a Republican fundraising event. Look for him to flex his muscles in coming months in the other early states: New Hampshire, South Carolina and Nevada.
Any reason why Ted Cruz isn't on the short list?
Yes I'm tired of politics. But I'm also tired of mowing the lawn and doing the laundry. All need to be done.
The sooner we identify good candidates, the better.
Not Rubio. Not Jindal. I want someone with ironclad, unquestionable eligibility. I don't want a token minority to pander to minorities. That is a losing strategy. I want the absolute best candidate, solidly conservative, regardless of race/gender/socioeconomic status. I'd include religion in that list, except that for me, the loyalty and honesty of any muslim is suspect.
Cue up the natural born birthers...
So?!?! Do you think that Emperor Obama will have an election in 2016? These people act as though everything is going to be as normal in 4 years. Geez...
Born in Canada, not eligible.
Meh. The message here? Conservatives...get lost.
NBC debate round 2.
Good luck to 'em, I suppose, but I've no intent of supporting the GOP any longer.
Maybe it premature to say so, but there are no indications at all the GOP has learned a damn thing from the past election.
have to love politico. It's Nov 2012 and they tell us in their expert opinion not to expect anyone to officially announce for many months. wow.
So now would be the time for the Walter William with Thomas Sowell as VP ground swell to begin. Let's try that and then hear them say were racists.
Correction: Dr. Walter E. Williams. and Dr. Thomas Sowell.
You can't be serious. He is not even a Senator yet.
Yeh, Kristie Kreme has cracked the code he runs as a Democrat but just calls himself a Republican.
At this point, I'd vote for either Ryan or Bachmann. I'm open to hearing what other potential candidates have to say.
Mia Love. Allan West. Sarah Palin. Many more examples that I can't think of off the top of my head. These were all great candidates who lost. I'm not saying don't run them. I'm saying don't run them if we're trying to pander. (Personally, I think Sarah Palin would be infinitely better than 0bama.) Also, don't put them in the #2 spot on the ticket which makes it look even more like pandering.
Stop alienating the base by running candidates who are "electable." Tried that. Failed.
Stop alienating the base AND the rest of the country by running candidates who are "entitled" to run because it's "their turn." Dole. McCain. Bush 1. Bush 2.
Those guys are old, no offense.
>>We also need to identify the bad ones and look beyond the presidential election and cut the bad stock out of the herd before they run for house and senate seats as well.
Amen to that.
The New World Order wants another of their own in the Oval Office in order to usher in the new global currency.
How 'bout the fact that he hasn't yet served a single day in the US Senate? Geeez....
Yeah. If they try to get elected by promising to give things away and to make life harder for the people who go out to work every day, I'LL STAY HOME in 2016.
This is the last time I vote for an uninspiring milktoast goody-goody.
Republican Party?
Since Jeb will have the same problems with conservatives that Romney did, I don't see a potential winner mentioned in the article...unless the Democrats nominate a white male candidate like Andrew Cuomo. Then, any of them can win.
That's funny, there's a whole lot of folks (self included) that have been calling Republicans "the stupid party" on here for YEARS now.
Needs to be
1. A governor.
2. A guy who has taken the Rats' best shots and still prevailed.
3. A guy who fights for what he believes in, regardless of what the polls say.
That man is Scott Walker.
I think Levin is usually spot on. I disagree with him on this one. I'm not arguing that Rubio is ineligible. What I am saying is that I want someone who is unquestionably eligible, someone where there is no doubt.
My other beef with Rubio is that he panders to the Hispanic vote with the Dream Act and similar positions. I don't know what the solution to the immigration problem is, if I did I'd be posting about it, but I'm pretty sure it's not easy amnesty. Reagan tried that and look where it got us.
I agree with you about "not only ideology." But we ought to have some list of ideological points and insist on a candidate who scores high on that list. The Dems seem to be a coalition of special interest voters or one-issue voters and are willing to overlook everything else so long as they get their special itch scratched. Blacks who want a black President are willing to ignore the pro-gay agenda they disagree with. Unions who want favorable treatment are willing to overlook the rest of the platform. Women who want free birth control or abortion are willing to overlook the rest of the platform. Those who want more "entitlements" are willing to overlook the rest of the platform. That's hard to compete with.
Please, drop the BS about eligibility. It didn't work on a guy with a questionable birth place and limited provenance. It certainly won't work on two guys who have naturalized Americans as parents.
2016. What a nauseating thought. I can already see the GOP-E promoting some big-government milquetoast, alongside FoxNews cheerleading and endless interviews of Rove with his blackboard. It's become a broken-record, with the needle stuck in the same groove, playing over and over again. And all increasingly moot, as the "takers" have now overwhelmed the "makers," rendering politics a near-pointless sideshow.
My preference is still for Palin, by a wide margin. But options ranging from third-parties to going Galt movements to even secession are looking far more enticing than anything I expect the ever-defective GOP to serve up.
Dunno why Levin, who is against illegal immigration keeps on carrying the water for Rubio.
Those who have 'senator' as their first names should stay out of it. Senators do not make good presidents. Look at the one currently in the Oval Office (when the golf games are rained out).
As for the list of governors, several of them have already opened their mouths and revealed they are more 'centrist' or 'moderate' leaning. Cristie's embrace of Obama may have been his 'macaca moment' for many. Martinez jumped on the bandwagon that blasted Romney for his 'gifts' comment. Jindal has less charisma than McCain.
Nope. No thrill up my leg from the list of names in this article.
Jeb? CLUE: Over 50% are still blaming his bro for the bad economy. Jeb wouldn't get as many electoral votes as McCain got. The Bush name is poison with more than half of the public.
Any reason why Ted Cruz isnt on the short list?
He hasn't even served a day yet. Maybe 2024 would be best for him.
"Read My Lips, No More Bushes."
I've seen this movie before, and I know how it ends.
The conservatives will beat each other to death in the primary, because they're too egotistical and self-serving to negotiate a single conservative standard-bearer in private.
The GOP-e anointed RINO will win the primary over his eleven dozen crazed conservative competitors, himself damaged below the waterline.
Then the anointed one will veer to the left, wreck his campaign (somehow) and in spite of the utterly toxic performance of his 'rat party over the previous four — make that eight — years, the dimocrap will win.
I'm really tired of re-runs.
Sarah Palin is mentioned, but as an observer.
Scratch that otherwise interesting article.
I will respectfully differ with you on this.
In my opinion it is not BS. The fact that people question it makes it a legitimate issue to be considered. And you can bet that if conservatives are questioning it, then liberals will attack it.
Saying that it didn't matter for Zero doesn't mean it's ok for us. I have a hard time believing that either Jindal or Rubio is absolutely the #1 best possible conservative candidate we could run even if without eligibility questions. (I have a similar attitude toward Jeb Bush or any Bush running. Isn't there anyone else??? It's not because I hate Bush. It's because I don't like political dynasties and I believe there are other, much more qualified candidates.)
Oh Yeah Bobby, That's just what we need a more intellectual approach to Conservatism.
I know that the Democrats elected an unqualified Muslim, but that doe not mean the Republicans want to cross that line and elect a non-Natural bor to the job.
>> That man is Scott Walker.
I like Scott Walker.
Two problems with Scott Walker, though:
a) No college degree. You don't care; I don't care. But it WILL be an obstacle to his getting elected.
b) He and his party couldn't deliver WI to Romney, even with boots on the ground fresh from his overwhelming victory in the recall. WFT is up with that?
Romney could not deliver Wisconsin, what did Walker have to do?
I still think that reflects more on the weakness of Romney as a candidate more than anything.
I'm not very certain that we'll have a presidential election in 2016.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
Legenda :
|Hotel Sekarang
|Tempat Menarik
100 Sunset Boutique Hotel
|Jl. Sunset Road No. 100, Kuta (Tunjukkan Peta)
|Jumlah kamar hotel : 45
Samudra Kuta Bali Hotel is located in Legian's lively shopping and entertainment area. It features a 24-hour front desk, massage services and rooms with a private balcony. Free parking is provided.
A 10-minute drive from Kuta Beach, b Hotel Bali is a contemporary minimalist-style hotel with a spa, children's playground and an outdoor pool. Free Wi-Fi throughout its premises. There is also free scheduled shuttle bus to Kuta Beach, Krisna Souvenir Centre and Legian Ground Zero. Guests who drive enjoy free parking privileges.
Conveniently located in Kuta, Adhi Jaya Sunset Hotel is within a 10-minute drive from popular shopping and entertainment spots. It features an outdoor swimming pool, a tour desk and a spa. Free Wi-Fi is available in the entire property.


text:
Showing 1 to 6 of 127 blog posts tagged with "python".
When it comes to programming, I have a belt and suspenders philosophy. Anything that can help me avoid errors early is worth looking into. The type annotation support that's be... Read more
Caktus CEO Tobias McNulty and Sales Engineer David Ray recently had the opportunity to attend a development sprint for the Wagtail Content Management System (CMS) in Reykjavik, ... Read more
For the first time, Caktus will be gold sponsors at PyCaribbean February 18-19th in Bayamon, Puerto Rico. We're pleased to announce two speakers from our team. Erin Mullaney, ... Read more
Last Friday, Caktus set aside client projects for our regular quarterly ShipIt Day. From gerrymandered districts to RPython and meetup planning, the team started off 2017 with ... Read more
Python 3.6 was released in the tail end of 2016. Read on for a few highlights from this release. New module: secrets Python 3.6 introduces a new module in the standard library... Read more
I recently attended Django Under The Hood in Amsterdam, an annual gathering of Django core team members and developers from around the world. A common theme discussed at the con... Read more
Feb 28, 2017 6:00 p.m.
Triangle Digital Project Managers: Kickoff Meeting
Caktus Group Tech Space | 108 Morris St., Suite 1B, Durham, NC 27701
Come network with digital project managers in Raleigh, Durham, and surrounding areas. AGENDA: 6:00 Networking 6:30 - 7:30 Introduction from our Hosts; Quick Survey; Discussion of Professional Development Opportunities 7:30 Questions & Announcements Learn more
Mar 7, 2017 5:30 p.m.
Code for Durham: Civic Hacking Session
Caktus Group Tech Space | 108 Morris St., Suite 1B, Durham, NC 27701
Have fun. Do good. Co-led by CTO Colin Copeland. This evening is like a study hall for ways to improve Durham. Join technologists, designers, developers, data scientists, map makers, and activists who are working on civic technology projects. This night is for those who want to: Work on existing civic ... Learn more


text:
Patriots Day
Terrorism: No End In Sight
There's a phrase used by sportscasters: "You can't stop him; you can only hope to contain him." It was coined, I believe, by Dan Patrick when he was at ESPN. It's invariably delivered tongue-in-cheek about an otherwise middling player who gets hot for one unexpected night. And it's still usually...
April 16 2013, 3:42 PM


text:
Club Axis found to be in violation of city code
A judge ruled a controversial Lawrence nightclub does not have enough parking spaces to meet city codes.
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When you forget a comma in a mail merge
The When you forget a comma in a mail merge meme was made with the 1990s First World Problems meme generator.
Like This Image? Share it with family and friends on Facebook, Google+, and Twitter, browse more 1990s First World Problems memes, or find the most popular memes created with MemesHappen.
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Earn your DO and MPH at the same time.
With ATSU's dual DO/MPH program, you can earn your Master of Public Health (MPH) through ATSU's College of Health Studies (ATSU-CGHS) while completing your doctor of osteopathic medicine degree at ATSU-SOMA. Students trained in ATSU-SOMA's innovative community campus model will be well prepared for a medical career in public health venues. The MPH requires additional courses completed online via ATSU-CGHS. Applications to the MPH program are accepted toward the end of students' first year at ATSU-SOMA.
After earning your DO and MPH degrees you will be able to do the following and more:
- Analyze issues of access, quality, and cost for populations, communities, and individuals
- Evaluate social determinants of health and health disparities at your community health center and beyond
- Hypothesize reasons for observed disparities
- Create interventions to address health disparities
- Design research studies to address health disparities
- Compare and contrast research methodologies
- Critically appraise public health and medical literature
- Define health literacy and apply its concepts to health promotion and disease prevention programs
- Apply knowledge and skills acquired from the curriculum and complete an academic paper suitable for publication
- Present research findings at national meetings
- Evaluate health promotion and disease prevention programs from a variety of perspectives
"Combining medical care and public health makes for an exciting, challenging and interesting career. The ability to affect both individuals and populations is powerful."
- Joy H. Lewis, DO, PhD, FACP
Director of Public Health Programs and
Practice Based Research
Advanced Credit Courses Credit Given For Completing SOMA Curriculum (12 Credit Hours)
Dual Credit Courses Courses Integrated Into SOMA Curriculum (12 Credit Hours)
CGHS Curriculum 10 Coures (4 Credit Hours Each)
Student Testimonials
"The DO/MPH program at ATSU-SOMA provides me the tools to tackle the complex issues of underserved populations not only at the patient bedside, but also through sustainable interventions in the community."
- Geraldine Malana


text:
Everything seems to have lined up well here for an early rebloom season. I
really thought we'd had too many hot days but I guess the rains lined up just
right! Something happened anyway.
Stalks are up on Diamond Blush, Renown, Again & Again, Lunar Whitewash,
Immortality & Pink Attraction (2). Arctic Encore is getting ready to open a
couple more blooms on a stalk I thought was finished. Two seedlings put up late
stalks. Late enough to be considered repeat bloom. Now I have bloom or
stalks on 8 different seedlings, which represent 3 different crosses. Two share
a parent.
All of these plants were planted last summer except Diamond Blush & this
clump of Renown, both were planted in 2004. It's only one stalk each, but it is
rebloom and it is June 23.
One of the 1812 seedlings has two stalks. This is the cross that already
has 50+ first fall plants to rebloom. These three are the first to bloom in
If you don't cross them, you can't plant them!
Betty W. in South-central KY Zone 6 ---
Bridge In Time Iris Garden@website:
_Reblooming Iris - Home Page_ (http://www.rebloomingiris.com/)
_iris-photos archives_ (http://www.hort.net/lists/iris-photos/)
_iris-talk archives_ (http://www.hort.net/lists/iris-talk/)
_AIS: American Iris Society website_ (http://www.irises.org/)
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE IRIS


text:
A plume-in-grid approach to characterize air quality impacts of aircraft emissions at the Hartsfield-Jackson Atlanta International Airport
- DOI: 10.5194/acp-13-9285-2013
This study examined the impacts of aircraft emis-sions during the landing and takeoff cycle on PM 2.5 con-centrations during the months of June and July 2002 at the Hartsfield–Jackson Atlanta International Airport. Primary and secondary pollutants were modeled using the Advanced Modeling System for Transport, Emissions, Reactions, and Deposition of Atmospheric Matter (AMSTERDAM). AMS-TERDAM is a modified version of the Community Multi-scale Air Quality (CMAQ) model that incorporates a plume-in-grid process to simulate emissions sources of interest at a finer scale than can be achieved using CMAQ's model grid. Three fundamental issues were investigated: the ef-fects of aircraft on PM 2.5 concentrations throughout north-ern Georgia, the differences resulting from use of AMS-TERDAM's plume-in-grid process rather than a traditional CMAQ simulation, and the concentrations observed in air-craft plumes at subgrid scales. Comparison of model re-sults with an air quality monitor located in the vicinity of the airport found that normalized mean bias ranges from −77.5 % to 6.2 % and normalized mean error ranges from 40.4 % to 77.5 %, varying by species. Aircraft influence av-erage PM 2.5 concentrations by up to 0.232 µg m −3 near the airport and by 0.001–0.007 µg m −3 throughout the Atlanta metro area. The plume-in-grid process increases concentra-tions of secondary PM pollutants by 0.005–0.020 µg m −3 (compared to the traditional grid-based treatment) but re-duces the concentration of non-reactive primary PM pol-lutants by up to 0.010 µg m −3 , with changes concentrated near the airport. Examination of subgrid-scale results indi-cates that median aircraft contribution to grid cells is higher than median puff concentration in the airport's grid cell and outside of a 20 km × 20 km square area centered on the air-port, while in a 12 km × 12 km square ring centered on the airport, puffs have median concentrations over an order of magnitude higher than aircraft contribution to the grid cells. Maximum puff impacts are seen within the 12 km × 12 km ring, not in the airport's own grid cell, while maximum grid cell impacts occur within the airport's grid cell. Twenty-one (21) % of all aircraft-related puffs from the Atlanta airport have at least 0.1 µg m −3 PM 2.5 concentrations. Near the air-port, median daily puff concentrations vary between 0.017 and 0.134 µg m −3 (0.05 and 0.35 µg m −3 at ground level), while maximum daily puff concentrations vary between 6.1 and 42.1 µg m −3 (7.5 and 42.1 µg m −3 at ground level) dur-ing the 2-month period. In contrast, median daily aircraft contribution to grid concentrations varies between 0.015 and 0.091 µg m −3 (0.09 and 0.40 µg m −3 at ground level), while the maximum varies between 0.75 and 2.55 µg m −3 (0.75 and 2.0 µg m −3 at ground level). Future researchers may consider using a plume-in-grid process, such as the one used here, to understand the impacts of aircraft emissions at other airports, for proposed future airports, for airport expansion projects under various future scenarios, and for other national-scale studies specifically when the maximum impacts at fine scales are of interest. Published by Copernicus Publications on behalf of the European Geosciences Union. 9286 J. Rissman et al.: A plume-in-grid approach to characterize air quality impacts
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text:
The MDR-NC7 headphones from Sony offer terrific sound quality combined with active noise cancellation, allowing you to enjoy your music in blissful peace. The technology inside the headphones listens to your environment, and then reduces it by over 85%, making jet engines and other constant noises fade away. A passive listening mode is available, allowing you to listen to music without the noise cancellation feature if the battery runs out. The headphones feature swivel earcups and a foldable design, allowing you to carry them easily for travel. A dual-plug airplane adapter is included for connecting to in-flight entertainment systems.
|Headphones Information
|Nominal Impedance
|40 Ohms (NC On) 45 Ohms (NC Off)
|Jack Plug
|1 x 3.5mm Stereo Mini Plug and 1/4
|Cable Length
|4.9' (1.5 m)
|4.7 oz (134g)
|Frequency Response
|30Hz - 20kHz


text:
More Videos...
INSANE 150 MPH CRASH! 800 hp Corvette Crashes Street Racing
Intense in car video of a 150 mph wreck, thankfully everyone walked away with scratches and bruises. Forum - http://www.thirdhonk.com/community/index.php Facebook - https://www.facebook.com/thirdhonk/
Illegal Street Racing Tragedies
Deaths caused by illegal street racing have reached epidemic proportions. According to the Department of Motor Vehicles from 2000 to 2006, drivers plead guilty to illegal speed contests in 50,000 cases. That's an average of 160 illegal races per week. In 2006, more than 6000 people were convicted of participating in illegal speed contests. Watch this moving video and see why Fast & Furious Hollywood Stuntman Sammy Maloof is in development of his own reality tv show to help solve this growing problem. Visit www.sammymaloof.com & email firstname.lastname@example.com to be a part.
STREET RACING COMPILATION LONG 2014 - 1 Hour Traffic Street Racing Compilation - NO.1
Subscribe ► http://bit.ly/1NUdxDs 1 Hour Street Racing Compilation 2014-2015 (Best Of) Full Video with original sounds. Subscribe and Drive Safe! Disclaimer: I do not condone street racing in any way
Lightning vs SRT4 cop chase at end
Ford Lightning SVT vs a fully built SRT4 3 runs: 1st:60 roll 2nd: 40 roll 3rd: dig Filmed with a GoPro After the 3rd race theres a cop chase (cop is unseen in camera) and the SRT runs a light and goes airborne FILMED IN MEXICO.


text:
Is K P Concrete Tanks incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
Are these details correct?
Hotfrog NewZealand provides information regarding K P Concrete Tanks in Auckland. K P Concrete Tanks is located at Main Road, Auckland Auckland and provides Commercial services. Contact them on 09-412 8666 or by visiting them on their website http://www.kpconcrete.co.nz.
Opening hours
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Shop 4, The Zone 14 - 28 Subway Road Auckland 2120
51 MacKelvie Street, Grey Lynn, Auckland
27 Anvil Rd Silverdale Auckland
Level 12 45 Queen Street Auckland 1010
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Compressor Upgrades, Re-rates & Revamps
Our global aftermarket network can offer a broad range of specialist services tailored to the precise needs of your process to ensure optimal performance and extended plant life. These include compressor upgrades, re-rates ad revamps.
We have supplied over 50,000 compressors to industries throughout the world, often for operation in extremely demanding roles such as process gas applications. Many of these machines continue to operate, several decades after installation, at the heart of our customers' operations. To keep them running at peak performance, we offer a suite of services that will return ageing equipment to optimum performance and extend its operating life.
In addition to the tailored engineering services listed below, each of which is described in greater detail on a dedicated page, we offer a comprehensive high-speed rotor balancing service at our Prague facility.
Compressor Re-rates
If the operating conditions or performance requirements of your compressor equipment changes, we can cary out a re-rate process that will match the unit to the new demands of your process without the need to replace the entire compressor.
Compressor Revamps, Rebuilds and Overhauls
For many compressors, a comprehensive overhaul or revamp can present a highly cost-effective way of returning the compressor to its peak performance. Overhauls, revamps and rebuilds can be carried out across all of our compressor technologies.
Compressor Upgrades
We offer a broad range of compressor upgrade options, involving the retrofitting of new technological developments to existing equipment to improve its performance and extend its lifetime.
To find out more please contact your local Howden Compressor Service Centre using our interactive map.
Frequently asked questions
Got a general enquiry
Request for technical information
Request for a quote


text:
1 language school in Manta offering Mini Group (max 6 students) courses from for a 2 week Spanish course.
Spanish courses in small groups of maximum 6 students allow better adaption to the needs of each student. A more intensive learning experience and highly recommended especially if improvement of Spanish speaking skills is main objective.
Sort by: Most popular Best rated (overall) Best rated teaching quality Best rated social activities Lowest price
School Size:
Lessons per week: 20
Max. students per class: 6
Starting dates: Every Monday
Comments: If you are the only one at your level, the course is replaced by 15 private lessons.
Total 2 weeks incl. taxes Price breakdown
|FREE cancellation
Map with location of Spanish schools in Manta
onscroll="return false;">


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Joseph Martin
(1760 - 1835)
A Patriot of the American Revolution for VIRGINIA - NORTH CAROLINA (Soldier, Spy). DAR Ancestor #: A074372
Wilhelm Franz Canaris MP
(1887 - 1945)
Wilhelm Franz Canaris (1 January 1887 – 9 April 1945) was a German admiral, and chief of the Abwehr, the German military intelligence service, from 1935 to 1944. During the Second World War, he ...
Noel Field
(1904 - 1970)
Noel Field (January 23, 1904 – September 12, 1970) was an American spy for the NKVD, whose activities before and after WWII allowed the Eastern Bloc to use his name as prosecuting rationale ...
Arthur Owens
(1899 - 1957)
"Arthur Graham White"
Arthur Graham Owens, later known as Arthur Graham White (14 April 1899 – 24 December 1957) was a Welsh double agent for the Allies during the Second World War. He was working for MI5 while app...
Steve Pieczenik MP
Steve R. Pieczenik, MD, PhD (born December 7, 1943) is an American psychiatrist, former United States Department of State official, author, and publisher.
Early life and education
Pieczenik was b...
Joshua Hett Smith
(1736 - 1818)
Photo: Color postcard showing the Treason House, Stony Point Road, West Haverstraw, NY. Belmont, later known as The Treason House and also called the Joshua Hett Smith House
Arthur Lee
(1740 - 1792)
Dr. Arthur Lee (20 December 1740 – 12 December 1792) was a physician and opponent of slavery in colonial Virginia in North America who served as an American diplomat during the American Revo...
Jonathan Odell
(1737 - 1818)
Rev. Jonathan Odell, graduate of Princeton and grandson of its first president, was a physician, poet, and clergyman. He went over to the British side in 1777, and patriots promptly confiscated his pro...
Thomas Haines Dudley
(1819 - 1893)
Thomas Haines Dudley was consul of the United States of America in Liverpool during the American Civil War. He was instrumental in leading efforts by the Federal Government to prevent British involve...
Beaumarchais MP
(1732 - 1799)
Pierre - Augustin Caron de Beaumarchais , né le 24 janvier 1732 à Paris où il est mort le 18 mai 1799 ; homme d'affaires français, musicien, poète et dramaturge, il e...
Malcolm Muggeridge
(1903 - 1990)
Thomas Malcolm Muggeridge (24 March 1903 – 14 November 1990), was a British journalist, author, media personality, and satirist. As a young man, Muggeridge was a left-wing sympathiser but he l...
Wilbur Crane Eveland
(1918 - 1990)
Wilbur Crane "Bill" Eveland III (July 1, 1918 – January 2, 1990) was a World War II veteran, a CIA station chief, and critic of U.S. foreign policy in the Middle East. His autobiographical boo...
Meredith Gardner
(1912 - 2002)
Meredith Knox Gardner (October 20, 1912 – August 9, 2002) was an American linguist and code-breaker. Gardner worked in counter-intelligence, decoding Soviet intelligence traffic regarding espi...
Colonel David de Crespigny Smiley LVO, OBE , MC & Bar
(1916 - 2009)
Colonel David de Crespigny Smiley, LVO, OBE, MC & Bar (11 April 1916 – 9 January 2009) was a British special forces and intelligence officer. He fought in the Second World War in Palestine, ...
Lorraine Copeland
(1921 - 2013)
Lorraine Copeland (born Elizabeth Lorraine Adie, 1921, died 27 April 2013) was an archaeologist specialising in the Palaeolithic period of the Near East. She was a secret agent with the Special Ope...
Norman Holmes Pearson
(1909 - 1975)
Norman Holmes Pearson (April 13, 1909 – November 5, 1975) was an American academic at Yale University, and a prominent counterintelligence agent during World War II. As a specialist on America...
Jane Archer
(1898 - 1982)
"Jane Sissmore", "Jane Archer"
Kathleen Maria Margaret Sissmore, MBE (1898 – 1982), was known as Jane Sissmore and then Jane Archer after her marriage in 1939. In 1929 she became the first female officer in Britain's Securi...
William King Harvey ("America's James Bond")
(1915 - 1976)
William King "Bill" Harvey (September 13, 1915 – June 9, 1976) was a Central Intelligence Agency officer, best known for his role in Operation Mongoose.
He was known as "America's James Bo...
Brig. General Henry B. Carrington (USA)
(1824 - 1912)
Henry Beebee Carrington (March 2, 1824 – October 26, 1912) was a lawyer, professor, prolific author, and an officer in the United States Army during the American Civil War and in the Old West ...
Peter Lunn
(1914 - 2011)
Peter Northcote Lunn (15 November 1914 – 30 November 2011) was a British alpine skier who competed in the 1936 Winter Olympics. As a spymaster in the early Cold War, he was noted for his resou...
Sir Claude Dansey
(1876 - 1947)
Lieutenant Colonel Sir Claude Edward Marjoribanks Dansey (10 September 1876 in South Kensington – 11 June 1947 in Bath, Somerset), also known as Colonel Z, Haywood, Uncle Claude, and codenam...
Sir Robert Gilbert Vansittart, 1st and last Baron Vansittart
(1881 - 1957)
Robert Gilbert Vansittart, 1st Baron Vansittart GCB GCMG MVO PC (25 June 1881 – 14 February 1957), known as Sir Robert Vansittart between 1929 and 1941, was a senior British diplomat in the pe...
Dame Marjorie Maxse DBE
(1891 - 1975)
Dame Sarah Algeria Marjorie Maxse, DBE, better known as Marjorie Maxse (26 October 1891 – 3 May 1975) was a political organiser and the first female chief organization officer of the Conserv...
Admiral Sir Hugh Francis Paget Sinclair KCB
(1873 - 1939)
Admiral Sir Hugh Francis Paget Sinclair, KCB (18 August 1873 – 4 November 1939), nicknamed "Quex", was a British intelligence officer. Between 1919 and 1921, he was Director of British Naval I...
Sir Stephen Hastings MC
(1921 - 2005)
Sir Stephen Lewis Edmonstone Hastings, MC, (4 May 1921, Knightsbridge, London – 10 January 2005, Wansford, Cambridgeshire) was a soldier, MI6 operative, Master of Foxhounds, author and Briti...
Nicholas Elliott
(1916 - 1994)
John Nicholas Rede Elliott, known as Nicholas Elliott, (15 November 1916 – 13 April 1994) was an MI6 Intelligence Officer; Honorary Attache, the Hague 1938-40; Acting Lieutenant, Intelligenc...
Sir Paul Dukes KBE ("The Man with a Hundred Faces")
(1889 - 1967)
Sir Paul Henry Dukes KBE (10 February 1889 – 27 August 1967) was a British author and MI6 officer.
Early life and family
Paul Henry Dukes was born the third of five children on 10 February...
Edith Tudor-Hart MP
(1908 - 1973)
Edith Tudor Hart (née Edith Suschitzky; 1908–1973), an Austrian-British photographer, communist-sympathiser and spy for the Soviet Union. Some of her work is in the National Gallery in ...
Sir Helenus Milmo, QC
(1908 - 1988)
Sir Helenus Milmo, QC (born Helenus Padraic Seosamh Milmo ; 24 August 1908 – 30 August 1988) was a British lawyer and High Court judge. His career was notable for his role in the prosecution tea...
Hugh Trevor-Roper
(1914 - 2003)
"Hugh Trevor-Roper", "Baron Dacre of Glanton"
Hugh Redwald Trevor-Roper, Baron Dacre of Glanton, FBA (15 January 1914 – 26 January 2003), was a historian of early modern Britain and Nazi Germany. He was Regius Professor of Modern Histor...
Major General Sir Stewart Graham Menzies, KCB, KCMG, DSO, MC
(1890 - 1968)
Major General Sir Stewart Graham Menzies , KCB KCMG DSO MC (Listeni/ˈmɪŋɨz/; 30 January 1890 – 29 May 1968) was Chief of MI6 (SIS), British Secret Intelligence Servic...
Martha Dodd
(1908 - 1990)
Martha Eccles Dodd (October 8, 1908 – August 10, 1990) was an American journalist and novelist. The daughter of William Edward Dodd, US President Franklin Delano Roosevelt's first Ambassador t...
Henry Wax Karnes
(1812 - 1840)
Henry Wax Karnes (September 8, 1812 – August 16, 1840) was notable as a soldier and figure of the Texas Revolution, as well as the commander of General Sam Houston's "Spy Squad" at the Battle of...
Emma Frances Stringfellow
(1843 - c.1929)
The teenage years are hard enough for any young woman. Just imagine what it must have been like for Emma Green. It was the spring of 1862, and Emma, then 18 years old, was the daughter of James and...
Lt. Gen. Keith B. Alexander MP
From his English Wikipedia page:
Keith Brian Alexander (born December 2, 1951) is a retired four-star general of the United States Army[1] who served as Director of the National Security Agency (DI...
Colonel Sidney F. Mashbir
(1891 - 1973)
Sidney Forrester Mashbir (12 September 1891 – 13 June 1973) was a senior officer in the United States Army who was primarily involved in military intelligence. Born in New York, he served in t...
Rear Admiral Ellis M. Zacharias
(c.1890 - c.1961)
Ellis Mark Zacharias, Sr. (January 1, 1890 – June 27, 1961) was a Rear admiral and naval attaché to Japan, who served in World War I and World War II. After World War II, he was appoint...
Field Marshal William Edmund Ironside, 1st Baron Ironside MP
(1880 - 1959)
Field Marshal William Edmund Ironside, 1st Baron Ironside usually went by his middle name of Edmund.
He was educated at Tonbridge School, Tonbridge, Kent, England.
He gained the rank of Boer Wa...
Edwin Luther Sibert
(1897 - 1977)
Edwin Luther Sibert (1897–1977) was a United States Army officer with the rank of Major General and served as intelligence officer during World War II and post-war Europe where he assisted in ...
Lydia Darragh
(1729 - 1789)
I wrote this based upon my research. -Elizabeth R. Laumas
Although the Darragh family were Quakers, and thus, pacifists, their son Charles fought in the Revolutionary War.
During the year 1777, whe...
Otto Katz MP
(1895 - 1952)
"André Simone"
Communist, agent, spy, theater man, Jew, and many others.
cf.: é_Simone
&: )
Judith Socolov MP
(1921 - 2011)
Judith Coplon Socolov (May 17, 1921 – February 26, 2011)[1] was an alleged KGB spy whose trials, convictions and successful appeals had a profound influence on espionage prosecutions during th...
Wilhelmus Lampman
(1751 - 1781)
September 9, 1780, a certificate by Justice Samuel Van Vechten of Albany NY lists "Elizabeth wife of Wilheim, as among those ordered out of the State or to some in the possession of the British.
Frank Carlucci, U.S. Secretary of Defense
(1930 - d.)
Frank Charles Carlucci III (born October 18, 1930) served as the United States Secretary of Defense from 1987 to 1989 in the administration of President Ronald Reagan. Prior to that, Carlucci served ...
William Harding Jackson
(1901 - 1971)
William Harding Jackson (II) ( March 25, 1901 – September 28, 1971) was a U.S. civilian administrator, New York lawyer, and investment banker who served as Deputy Director of the Central Int...
Michael I Roark
(1745 - 1839)
This spelling appeared in Michaels census listing in the fi rst census of the United States in Rockingham County Virgin ia. In the Godspeed's History of East Tennessee, pp 875 Mic haels name appears as...
Robie Macauley
(1919 - 1995)
Robie Mayhew Macauley (May 31, 1919 – November 20, 1995) was an American editor, novelist and critic whose literary career spanned more than 50 years.
George Lockhart of Carnwath MP
(c.1675 - 1731)
Wikipedia Biographical Summary
" Sir George Lockhart of Lee (1673 – 17 December 1731), of Carnwath, South Lanarkshire, also known as Lockhart of Carnwath , was a Scottish writer, spy and polit...
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Samuel A. Adams
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Monica Emily Wichfeld
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A Patriot of the American Revolution for SOUTH CAROLINA. DAR Ancestor # A069020
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(1890 - 1917)
"שרה גיבורת ניל"י"
Sarah Aaronsohn (January 5, 1890 – October 9, 1917) was a member of Nili, a ring of Jewish spies working for the British in World War I, and a sister of notable botanist Aaron Aaronsohn. Sometim...
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Julius Rosenberg MP
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Ethel Rosenberg MP
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Laura Houghtaling Ingalls (December 14, 1893 – January 10, 1967) was a pilot who won the Harmon Trophy.
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Private Samuel Slavens (USA)
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Participated in the Great Locomotive Chase, or Andrews' Raid, a military raid that occurred April 12, 1862 in northern Georgia during the American Civil War. Hanged as a spy; received Medal of Honor ...
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Violette Szabo, spy MP
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Amos Gates MP
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GATES, AMOS (1799–1883). Amos Gates, said to be the first settler in Washington County, was born in Kentucky on July 25, 1799, the son of William Gates. Th...
Nancy Wake MP
(1912 - 2011)
"The White Mouse", "Nancy Wake"
Nancy Grace Augusta Wake AC, GM (30 August 1912 – 7 August 2011) served as a British agent during the later part of World War II. She became a leading figure in the maquis groups of the French R...
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text:
The emergence of blood abnormalities, an adult ability to digest milk, and changes in our physical appearance point to the continued evolution of the human race.
Ebola's Immune Escape
November 3, 2015|
The virus can persist in several tissues where the immune system is less active. Researchers are working to better understand this phenomenon and how it can stall the clearing of Ebola in survivors.


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Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy
- Thasia G Woodworth1 and
- Daniel E Furst1Email author
DOI: 10.1186/ar4677
© Woodworth and Furst; licensee BioMed Central Ltd. 2014
Published: 30 July 2014
As translational clinical researchers familiar with the risk-benefit of hematopoietic stem cell transplantation in autoimmune diseases, we are intrigued by the recent report of umbilical cord mesenchymal stem cell (UC-MSC) transplantation in treatment-refractory systemic lupus erythematosus nephritis by Wang and colleagues. They report the results of an open-label single-arm multicenter phase I/II study. This stimulated us to examine whether collective data from this group provide sufficient evidence for the feasibility, safety, dose rationale, and potential efficacy of UC-MSCs to conduct a randomized controlled trial in such patients. Results, though confounded by variable baseline prednisone and immuno-suppressive treatment, appear to indicate near-term response rates of approximately 50%, which are comparable to those seen with hematopoietic stem cell transplantation but with less morbidity and mortality.
Overview of open-label phase I/II studies to evaluate mesenchymal stem cells (1 × 10 6 per kg) in treatment-refractory systemic lupus erythematosus
Authors (date)
ClinicalTrials.gov protocol number
Study design/duration of follow-up
Number of patients
MSC type/regimen
Safety: deaths/serious infection
PD markera
Sun et al. [2]
Single-arm/ median of 8.25 months (range of 3 to 28 months)
UC, single infusion
CYC 0.8 to 1.8 mg/kg intravenously, 2 to 4 days
Percentage of Treg cells increased at 3 months (P = 0.03)
'Decreasing SLEDAI and proteinuriab in all patients'
Liang et al. [3]
Single-arm/17.2 ± 9.5 months
BM, single infusion
Included in protocol, but NR
Percentage of Treg cells increased at 1 week and 3 and 6 months (P <0.05)
'Decreasing SLEDAI and proteinuriab in all patients'
Wang et al. [4]
Unblinded-randomized, 2-arm/12 months
BM, UC, single versus 2× (7 days apart)
CYC 10 mg/kg per day, day 4, 3, and 2
CR single: 16/30 (53%); double: 8/27 (29%)
Wang et al. [5]
Single-arm/mean of 27 months
BM, UC, single infusion, 18 patients retreated at relapse
CYC 10 mg/ kg/day, day 4, 3, and 2
CR in 23/83, relapse 10/83
Wang et al. [1]
cNCT 01741857
UC, 2× infusion, 7 days apart)
MCR 13/PCR 11, 7 relapse
Protocol NCT01741857, first posted on 26 November 2012 and updated 1 November 2013, appears to be the protocol for the study recently published in Arthritis Research & Therapy[1]. The report largely reflects the protocol, although dose is not described and patient entry criteria required a dose of prednisone of more than 20 mg/day. In the report, only 10 of 40 patients were receiving prednisone of more than 20 mg/day, and one dose - 1 × 106 cells per kg, infused twice 7 days apart - was evaluated. The umbilical cord mesenchymal stem cells (UC-MSCs) for infusion were centrally prepared by using a well-standardized, quality-controlled method, and infusions were well tolerated. One-year mortality (two patients with uncontrolled SLE) and morbidity (five serious infections) compare favorably to those seen with hematopoietic stem cell transplantation in patients with SLE [6].
Previously reported studies by this group [2–5] evaluated stem cells derived from either bone marrow of healthy relatives or umbilical cords donated by healthy consenting mothers in patients with treatment-refractory SLE. Most patients had active SLE nephritis despite receiving prednisone of more than 20 mg and immuno-suppression with cyclophosphamide, mycophenylate mofetil, or leflunomide or a combination of these. In addition, they usually received 'conditioning' by cyclophosphamide 0.8 to 1.8 mg/kg per day for 3 days prior to transplant. In contrast, in the recently reported study [1], only UC-MSCs were transplanted, without 'conditioning', in patients with active treatment-refractory SLE nephritis receiving a more variable background of prednisone, often less than 20 mg/day, and immunosuppression. Although efficacy is difficult to evaluate because major clinical response (MCR) required that prednisone be tapered to less than 10 mg/day, while maintaining improvements in disease activity measured by British Isles Lupus Assessment Group and Systemic Lupus Erythematosus Disease Activity Index, conditioning is apparently not needed. However, because 18 of 40 patients were receiving prednisone of less than 20 mg/day at the start of the study, the efficacy criterion of 'tapered' prednisone is difficult to assess. Although 24 responses - 13 MCR and 11 partial clinical response (CR) - are reported, 6 MCR and 6 partial CR cannot be verified in the reported data, because prednisone tapering appears not to meet criteria for response. In addition, relapse occurred within a year in 6 patients, most receiving at least 20 mg prednisone at baseline. Nevertheless, there may be some evidence for potential efficacy or perhaps corticosteroid sparing, but dose regimen results are not sufficiently clear, or defined by relevant pharmacodynamic activity, to identify a specific UC-MSC dose to use for a randomized controlled trial (RCT).
Review of previous reports may provide some additional insight (Table 1). One open-label study indicates that UC-MSCs and bone marrow mesenchymal stromal cells, each dosed at 1 × 106 cells per kg, are equally effective, based on CR rate [4]. In the same study, patients were randomly assigned in an unblinded manner to receive a single infusion versus two infusions of MSC, 7 days apart; again, no significant difference in CR rate was observed. Of interest are two studies that reported (Table 1) a significant decrease in proteinuria and an increase in peripheral blood regulatory T (Foxp3) cells 3 to 6 months after infusion, potentially providing evidence of a pharmacodynamic effect of MSCs [2, 3]. No correlations with improvement in clinical status were reported, however.
Overall, Wang and colleagues have demonstrated the feasibility of a multicenter trial, as they apparently recruited a sufficient number of patients in a reasonable period of time, and safety was acceptable. Apparently, conditioning pre-MSC dosing is not required, although this aspect of the treatment has not been studied in a controlled manner. It should be pointed out that the collective published results may reflect the fact that some of the same patients were reported in more than one study. For example, two publications [1, 4] refer to the same NCT00698191 protocol; thus, recruitment feasibility may be optimistic. The dose of stem cells, with biologic activity shown in two studies, may have been defined, although it is not absolutely clear (see above caveats). There are also some indications of an appropriate population, but again there seems to be some lack of clarity based on the recently published study [1] where the endpoints were not actually met.
The lack of a well-rationalized dosing regimen, together with a lack of results from an appropriately designed, well-controlled study, makes it extremely difficult to develop a treatment approach with UC-MSCs. Nevertheless, we feel that these results should not be discarded without a proper RCT. Although there may be some challenges in designing a well-controlled, double-blind, placebo-controlled RCT in patients with prednisone-dependent active SLE nephritis, this should be attempted [7].
Clinical response
Major clinical response
Mesenchymal stem cell
Randomized controlled trial
Systemic lupus erythematosus
Umbilical cord mesenchymal stem cell.
We wish to thank Bevra Hahn for her review of and agreement with this editorial.
Authors' Affiliations
- Wang D, Li J, Zhang Y, Zhang M, Chen J, Li X, Hu X, Jiang S, Shi S, Sun L: Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther. 2014, 16: R79-10.1186/ar4520.PubMed CentralView ArticlePubMedGoogle Scholar
- Sun L, Wang D, Liang J, Zhang H, Feng X, Wang H, Hua B, Liu B, Ye S, Hu X, Xu W, Zeng X, Hou Y, Gilkeson GS, Silver RM, Lu L, Shi S: Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum. 2010, 62: 2467-2475. 10.1002/art.27548.View ArticlePubMedGoogle Scholar
- Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S, Hou Y, Zeng X, Gilkeson GS, Sun L: Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis. 2010, 69: 1423-1429. 10.1136/ard.2009.123463.View ArticlePubMedGoogle Scholar
- Wang D, Akiyama K, Zhang H, Yamaza T, Li X, Feng X, Wang H, Hua B, Liu B, Xu H, Chen W, Shi S, Sun L: Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus. Clin Dev Immunol. 2012, 2012: 273291-PubMed CentralPubMedGoogle Scholar
- Wang D, Zhang H, Liang J, Li X, Feng X, Wang H, Hua B, Liu B, Lu L, Gilkeson GS, Silver RM, Chen W, Shi S, Sun L: Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant. 2013, 22: 2267-2277.View ArticlePubMedGoogle Scholar
- Tyndall A, Houssiau FA: Mesenchymal stem cells in the treatment of autoimmune diseases. Ann Rheum Dis. 2010, 69: 1413-1414. 10.1136/ard.2010.132639.View ArticlePubMedGoogle Scholar
- Collins E, Gilkeson G: Hematopoetic and mesenchymal stem cell transplantation in the treatment of refractory systemic lupus erythematosus - where are we now?. Clin Immunol. 2013, 148: 328-334. 10.1016/j.clim.2013.01.009.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


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Our tapas are portions of dishes typically found in the gastronomy of Southern Spain and all of our dishes are home-cooked using the best ingredientsVIEW MENUCONTACT US
The dark wood floors and wooden ceiling beams combined with a simple, rustic décor offer a cosy and informal setting suited to both a quick bite to eat or a special occasionVIEW MENUSBOOK NOW
Our extensive menu has a wide range of hot and cold tapas, salads, cured meats and of course "paellas"; a traditional Spanish rice dish. We also offer a range of tapas selection menus, great for large groups and for the indecisive diners who find it too hard to choose from our large range of dishes!
The restaurant is situated on Leazes Park Road in part of the Gallowgate area of Newcastle and parts of the building are said to date back many years to the times when people were hung in "the barn". The building is rumoured to be haunted…
El Coto opened in Durham in May 2008 serving the same delicious tapas as our Newcastle restaurant in similar rustic, intimate surroundings on Hallgarth Street.
Dining is over two floors and there is a bar area to enjoy a drink before and after your meal.
The property was at one point owned by the Durham branch of the National Union of Mineworkers and some time ago traded as the "and Albert" restaurant who had a special oval table reserved for committee meetings.
The restaurant was named "and Albert" as the Victoria pub is situated on the opposite side of the street.


text:
This activity has GetYourGuide's stamp of approval! Exceptional customer service, knowledgeable staff, and a great time guaranteed.
Las Vegas Explorer 30-Day Pass
Duration: 30 days
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Traveling north from St. George via I-15 take Exit 16, then travel three miles east on Hwy. U9, then turn left onto Hwy U318 to the park entrance. (Open in Google Maps)
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Product ID: 21220


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Re-enactors from all over the United States and Canada will descend on Lighthouse Point in Ogdensburg this weekend for Founder's Day. Highlights will include mock battles, a ball, races and stories. For more details see our story.
©North Country This Week P.O. Box 975, 19 Depot St., Potsdam, NY 13676 315-265-1000 firstname.lastname@example.com


text:
The park bench was deserted as I sat down to read,
Beneath the long, straggly branches of an old willow tree;
Disillusioned by life, with good reason to frown,
For the world was intent on dragging me down.
And, if that weren't enough to ruin my day,
A young boy approached me, all tired from play;
He stood right before me with his head tilted down,
And said with excitement, "Look what I found!"
In his hand was a flower, and a pitiful sight,
With its petals all worn...from too little rain or light;
Wanting him to take his dead flower and go play,
I faked a small smile and then shifted away.
But instead of retreating, he sat next to me,
Placed the flower to his nose and declared cheerfully;
"It sure smells pretty and it's beautiful, too,
That's why I picked it. Here, it's for you."
The weed before me was dying or dead,
Not vibrant of colors, orange, yellow or red;
But I knew I must take it, or he might never leave,
So, I reached for the flower and said, "Just what I need."
But, instead of him placing the flower in my hand,
He held it mid-air without reason or plan;
It was then that I noticed for the very first time,
That weed-toting boy could not see; he was blind!
I heard my voice quiver...tears shown in the sun,
As I thanked him for picking the very best one;
"You're welcome," he smiled, and then ran off to play,
Unaware of the impact he'd had on my day.
© Copyright 2017 Elizabeth Smith. All rights reserved.
Status: Finished
Genre: Poetry
Just asking but is this a poem? Well it is damn good!!!
I think this a special poem and it rhymes really good, Elizabeth:) Good job. Thanks for sharing.
Great job with this. I loved it. It was very well written and flowed well. Thank you for sharing it.
Touching ending...i enjoyed it!
lyk ...it
oh wow! That was really good! :D i really liked it honestly, I think it sounds professionally written, Good work
(and you started my book, i posted the next chapters if you want to read it: )
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Poem / Poetry
Poem / Poetry
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text:
Product Description
Rm115 / unit exclude GST
Installation Charge RM20/unit exclude GST
assembly is not included
Size : 1745H x 1202W x 300D (mm)
material: malamine chipboard
pls call for stock availability and delivery coverage
Free delivery within Klang Valley with the purchase above Rm500.00.
only own collection for out of klang valley customer
Prices subjected to change without prior notice.
Email: email@example.com
Contact Person : LIZA 016 2020 311 or EDMUND 019 262 0321
Pls leave sms or whatapp message if phone call no answered, we will get back to you asap
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saturday, sunday and public holiday closed
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text:
Seagar's Prime Steaks & Seafood is Northwest Florida's only AAA Four-Diamond restaurant. Specializing in the finest prime beef and freshest seafood available, Seagar's also features a private reserve wine list featuring over 800 labels and private dining facilities for intimate, as well as opulent, business dinners and special events.
Located at the Hilton Sandestin.
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