text:
Brostallicin and Cisplatin in Treating Patients With Metastatic Breast Cancer
|Tracking Information
|First Received Date ICMJE
|March 18, 2010
|Last Updated Date
|August 11, 2016
|Start Date ICMJE
|June 2010
|Primary Completion Date
|June 2012 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|PFS rate [ Time Frame: 3 months ]
|Original Primary Outcome Measures ICMJE
|3-month progression-free survival (PFS) rate
|Change History
|Complete list of historical versions of study NCT01091454 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Brostallicin and Cisplatin in Treating Patients With Metastatic Breast Cancer
|Official Title ICMJE
|Phase II Trial of Brostallicin and Cisplatin in Patients With Metastatic Triple Negative Breast Cancer
|Brief Summary
|This phase II trial studies how well brostallicin and cisplatin work in treating patients with breast cancer that has spread to other parts of the body (metastatic) and does not have estrogen receptors, progesterone receptors, or large amounts of human epidermal growth factor receptor 2 (HER2) on its cells (triple-negative). Drugs used in chemotherapy, such as brostallicin and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from spreading.
|Detailed Description
I. To identify any clinical efficacy of brostallicin and cisplatin in the treatment of breast cancer patients having a triple negative (estrogen receptor [ER]/progesterone receptor [PR]/HER2 negative) phenotype, as measured by progression-free survival (PFS) at 3 months.
I. To describe the confirmed tumor response rate of patients with measurable disease receiving brostallicin and cisplatin.
II. To describe the duration of response in patients with measurable disease receiving brostallicin and cisplatin.
III. To describe the 6-month progression-free survival of patients receiving brostallicin and cisplatin.
IV. To describe the overall survival (OS) of patients receiving brostallicin and cisplatin.
V. To evaluate the adverse event profile of the study regimen (adverse events graded using the Cancer Therapy Evaluation Program [CTEP] Active Version of the Common Terminology Criteria for Adverse Events [CTCAE]).
Patients receive cisplatin intravenously (IV) over 2 hours on day 1 and brostallicin IV over 10 minutes on day 2. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months until disease progression and then every 6 months for up to 5 years.
|Study Type ICMJE
|Study Phase
|Phase 2
|Study Design ICMJE
|Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Condition ICMJE
|Triple-negative Breast Cancer
|Intervention ICMJE
|Study Arms
|Experimental: Treatment (cisplatin and brostallicin)
Patients receive cisplatin IV over 2 hours on day 1 and brostallicin IV over 10 minutes on day 2. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Active, not recruiting
|Estimated Enrollment ICMJE
|Completion Date
|Not Provided
|Primary Completion Date
|June 2012 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria
Exclusion Criteria
|18 Years and older (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|Plan to Share Data
|Not Provided
|IPD Description
|Not Provided
|Responsible Party
|Alliance for Clinical Trials in Oncology
|Study Sponsor ICMJE
|Alliance for Clinical Trials in Oncology
|Collaborators ICMJE
|National Cancer Institute (NCI)
|Investigators ICMJE
|Information Provided By
|Alliance for Clinical Trials in Oncology
|Verification Date
|August 2016
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


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This application proposes a 5-year continuation of a pre- and postdoctoral training program in development and psychopathology (current funded period is 07/01/04-06/30/09) that we have refined during a 10-year funding period. Our training model integrates the research of faculty and scientists at the University of Oregon (DO), Oregon Social Learning Center, and Oregon Research Institute who are internationally known for their research in neuroscience, developmental mechanisms, and intervention science. This collaborative design makes us uniquely poised to offer a training program in the translation of developmental and neurobiological research to clinical interventions with children and families. Training will emphasize integration across 4 domains of research: (a) neurodevelopmental systems, including neuroscience and training in technology and application of neurobehavioral approaches;(b) relationship dynamics, including social interaction processes that exacerbate risk for the development of mental health diagnoses, or provide protection;(c) prevention and intervention science with opportunities to work on multiple funded intervention trials occurring in diverse contexts;and (d) diversity training for enhancing knowledge and skills to conduct research with diverse populations. The program includes 2 major components: (a) individualized mentorship of trainees, involving a primary and secondary mentor with research that spans 2 different domains, and (b) an ongoing weekly working group seminar involving trainees and interested students, faculty, and researchers, including workshops, formal and informal presentations, and organized discussions of readings. Funding is sought for 6 pre-doctoral trainees and 2 postdoctoral trainees in any given year of support. Pre-doctoral students will be selected from among doctoral students in clinical, counseling, and school psychology at UO, all APA-accredited programs that include a significant number of potential minority candidates. Postdoctoral trainees will be selected from national advertisement in print and Internet/email-based announcements. Advanced training in statistics and methodology will be provided in each area of focus, with applied workshops included in the training seminars.
|Smith, Justin D; Stormshak, Elizabeth A; Kavanagh, Katherine (2015) Results of a pragmatic effectiveness-implementation hybrid trial of the Family Check-up in community mental health agencies. Adm Policy Ment Health 42:265-78
|Smith, Justin D; Dishion, Thomas J; Shaw, Daniel S et al. (2015) Negative relational schemas predict the trajectory of coercive dynamics during early childhood. J Abnorm Child Psychol 43:693-703
|Smith, Justin D; Dishion, Thomas J; Shaw, Daniel S et al. (2014) Coercive family process and early-onset conduct problems from age 2 to school entry. Dev Psychopathol 26:917-32
|Smith, Justin D; Knoble, Naomi B; Zerr, Argero A et al. (2014) Family check-up effects across diverse ethnic groups: reducing early-adolescence antisocial behavior by reducing family conflict. J Clin Child Adolesc Psychol 43:400-14
|Dishion, Thomas J; Kim, Hanjoe; Stormshak, Elizabeth A et al. (2014) A brief measure of peer affiliation and social acceptance (PASA): validity in an ethnically diverse sample of early adolescents. J Clin Child Adolesc Psychol 43:601-12
|Martin, Christina Gamache; Kim, Hyoun K; Bruce, Jacqueline et al. (2014) Child diurnal cortisol rhythms, parenting quality, and externalizing behaviors in preadolescence. Psychoneuroendocrinology 40:170-80
|Van Ryzin, Mark J; Nowicka, Paulina (2013) Direct and indirect effects of a family-based intervention in early adolescence on parent-youth relationship quality, late adolescent health, and early adult obesity. J Fam Psychol 27:106-16
|Smith, Justin D; Dishion, Thomas J; Shaw, Daniel S et al. (2013) Indirect effects of fidelity to the family check-up on changes in parenting and early childhood problem behaviors. J Consult Clin Psychol 81:962-74
|Van Ryzin, Mark J; Dishion, Thomas J (2013) From antisocial behavior to violence: a model for the amplifying role of coercive joining in adolescent friendships. J Child Psychol Psychiatry 54:661-9
|Peake, Shannon J; Dishion, Thomas J; Stormshak, Elizabeth A et al. (2013) Risk-taking and social exclusion in adolescence: neural mechanisms underlying peer influences on decision-making. Neuroimage 82:23-34
Showing the most recent 10 out of 16 publications

subset: commoncrawl


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Click any word in a definition or example to find the entry for that word
90% of the time, speakers of English use just 7,500 words in speech and writing. These words appear in red, and are graded with stars. One-star words are frequent, two-star words are more frequent, and three-star words are the most frequent.
The thesaurus of synonyms and related words is fully integrated into the dictionary. Click on the thesaurus category heading under the button in an entry to see the synonyms and related words for that meaning.more
The results of the survey lead to some surprising conclusions.
It's hardly surprising (=not at all surprising) that she's angry, considering what you said.
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a combination of a hotdog and a hamburger in a specially designed bread bunBuzzWord Article
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9 Oct 2009
Coffee is a drink which used mostly at work place. Coffee is very easy to make and it has a very strong taste. I am great lover of coffee and drink at least 5 cups daily.
|Cold water
|3⁄4 Cup (12 tbs)
|2 Tablespoon, ground
Select the particular grind of coffee that your coffee maker requires.
Recipe Summary
Difficulty Level:Easy
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1 Calories from Fat 0
% Daily Value*
Total Fat 0 g
Saturated Fat 0 g
Trans Fat 0 g
Cholesterol 0 mg
Sodium 7.9 mg0.3%
Total Carbohydrates 0.13 g0.04%
Dietary Fiber 0 g
Sugars 0 g
Protein 0 g
Vitamin A Vitamin C
Calcium 0.5% Iron
*Based on a 2000 Calorie diet
Coffee Recipe


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My latest on CITEworld. Just when you got used to BYOD, along comes BYO - everything. The enterprise may never be the same.
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"Big Island Explorations" Top 5 Page for this destination Hawaii (Big Island) by cjg1
Hawaii (Big Island) Travel Guide: 1,949 reviews and 4,983 photos
I had first visited the Big Island many years ago to explore Hilo, some waterfalls and one of the volcanos. It was a short one day trip.
I recently returned in February 2013 with my wife as one of our stops along our Hawaiian Cruise. We arrived in Hilo and took a day tour. The tour brought us to several waterfalls including Akaka and Rainbow Falls. My wife loves waterfalls so it was important for me that she get her fill of these beautiful sights while we were here. It was an incredible visit, as it had been raing for several days prior to our visit, and the waterfalls were at full gushing. It was a fun time, and we saw many beautiful waterfalls, a macadamia nut plantation, some lava tubes, botanic gardens,gorgeous coastline and had a great BBQ by a waterfall.
Our cruise also brought us to Kona the following day;it was a first time for both my wife and I. We spent our short time here enjoying some restaurants and bars, exploring the town and shopping. The main street of Ali'i Way was full of cute shops and historic spots to explore. We enjoyed this relaxing day very much.
Our highlight of this trip though was the evening sail out of Hilo. We were able to watch the lava flow in the darkness as it journeyed into the ocean. It was amazing sitting on our balcony and watching the fiery red lava cascade into the ocean waters....what an experience!
Reviews (48)
Crazy Shirt is a store I have seen in many location on the Main Land of the U.S. Here in Hawaii they have several... more travel advice
Macadamia nuts are very popular in Hawaii and are used in a a variety of foods as main ingredients and well as... more travel advice
My last visit to the Big Island in 2013, allowed us a tour of a Macadamia Nut Plantation. We were able to see the trees,... more travel advice
Banyan Drive is a street at the shoreline of Hilo that is lined with huge Banyan Trees. This street is also known as the... more travel advice
Comments (1)
how did you like hawaii?? akaka falls is always empty for some reason! i think no one bothers to find it because its a little out of the way. next time you're here give me a call, i'll be glad to show you around.
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9A Time Delay Class J Fuse 600VAC/300VDC
EATON BUSSMANN| Zoro #: G1406526| Mfr #: LPJ-9SP
Zoro #: G1406526Mfr. Part #: LPJ-9SP
$24.75 /ea
Orders over $50.00 ship free. DetailsStandard ground shipping
Technical Specifications
|Zoro #: G1406526 Mfr #: LPJ-9SP
|Rejection / Nonrejection: Nonrejection
|Element: Dual
|Body Material: Melamine
|Standards: CE/UL-Special Purpose Guide JFHR/CSA Class 1422-02
|Fuse Voltage Rating: 600VAC/300VDC
|Fuse Speed: Time Delay
|Item: Fuse
|Fuse Interrupt Rating: 300kA at 600VAC, 100kA at 300VDC
|Depth: Not Applicable
|Class: J
|Width: Not Applicable
|Functionally Equal To: Littelfuse JTD
|Series: LPJ
|Fuse Holder Code: Z
|Body Style: Cylindrical
|Length: 2-1/4"
|Fuse Amps: 9A
|Green Environmental Attribute: RoHS Compliant
|Indicating / Nonindicating: Nonindicating
|Diameter: 13/16"
|Country of Origin (subject to change): Mexico
Product Description
Fuse, 9A Fuse Amps, Nonindicating, LPJ Series, 600VAC/300VDC Fuse Voltage Rating, Time Delay, Dual Element, J Class, Body Material Melamine, Nonrejection, Body Style Cylindrical, Fuse Interrupt Rating 300kA at 600VAC, 100kA at 300VDC, Length 2-1/4 In., Width Not Applicable, Fuse Holder Code Z, Depth Not Applicable, Diameter 13/16 In., Functionally Equal To Littelfuse JTD, Standards CE/UL-Special Purpose Guide JFHR/CSA Class 1422-02


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Traditional Medicinals Weightless Cranberry Herbal Tea ReviewSubmitted by Robin M. on Fri, 07/30/2010 - 08:00
Weightless Cranberry Herbal Tea is part of a line of teas produced by Traditional Medicinals that includes the original Weightless Tea and the Weightless Cinnamon-Spice.
Trec Nutrition Weight Loss Protein Shake ReviewSubmitted by Marina on Thu, 07/29/2010 - 08:00
In order to lose fat and build muscle you need to exercise but also feed yourself the necessary nutrients in the right proportions.
Whey protein is a great supplement that helps you not only achieve a low-calorie, nutrient rich diet but also effectively perform and quickly recover from your intense cardio and weight lifting workouts.
Lifecore Fitness R100 Commercial Rowing Machine ReviewSubmitted by Rhian Hunt on Wed, 07/28/2010 - 08:00
The Lifecore R100 is one of the best rowers in the market today. It is a commercial quality rowing machine which is also available for home use.
The R100 is a formidable-looking machine with a large frontal drum holding a solid steel magnetic flywheel, a tough extruded aluminum frame with steel supports, ergonomic design, and a sophisticated, high-quality computer monitor that offers a wide range of detailed and timely information to the exerciser.
Herbalife Formula 1 Nutritional Shake Mix 750g ReviewSubmitted by Saadia on Tue, 07/27/2010 - 02:16
You are a vegetarian. Perhaps, allergic to dairy. Or maybe you need to up your intake of cholesterol-lowering foods. Added to the woes is that you're overweight too.
High protein, nutritionally balanced meal replacement shakes, like Herbalife Formula 1, can be life-savers and weight-reducers for those of you who fall within one, a few or all of the above categories.
Billy Blanks' Tae-Bo Cardio Workout DVD ReviewSubmitted by Stephanie on Sun, 07/25/2010 - 07:41
Work out your entire body and use muscles you never knew you had with Tae-Bo, a fun and exciting way to drop the pounds.
Tae Bo can do great things for your body. Living proof is Billy Blanks' very own daughter, Shelley, who accompanies her father in this Tae Bo DVD.
Biggest Loser Cardio Max DVD Review - Jillian MichaelsSubmitted by Robin M. on Sat, 07/24/2010 - 08:08
Cardio Max DVD is one of the (now many) workout videos created by the makers of our favorite reality TV show.
It is a workout designed so that "we will burn as much fat as we possibly can", according to Bob Harper, one of the 3 personal trainers featured in this DVD.
TwinLab Metabolift, Ephedra-Free, Weight Loss Supplement ReviewSubmitted by Marina on Fri, 07/23/2010 - 03:02
TwinLab Metabolift Weight Loss Supplement, Ephedra Free Formula is a dietary supplement that works on fat burning with a mix of active ingredients.
The mix is patented and designed to help you lose weigh quickly and to increase your energy level. It seems that this promise comes with strings attached, since the manufacturer's website comes with half page of warnings about dangers to your health if the dose is exceeded.
Olimp Nutrition Thermo Fat Burner ReviewSubmitted by Marina on Thu, 07/22/2010 - 08:00
Olimp Nutrition Thermo Fat Burner is advertized as one of the strongest weight loss pills in the market, without must justification for such a lofty title. As a dietary supplement, it contains herbal extracts from green tea, bitter orange, guarana and garcinia cambogia (mangosteen).
First Degree Fitness WR-N Neptune Rower ReviewSubmitted by Rhian Hunt on Wed, 07/21/2010 - 13:26
Another mid-price entry in the rowing machine market, the First Degree Fitness WR-N Neptune Rower makes use of a water tank for resistance and includes a convenient hand pump for filling and emptying the tank. It can support users of up to 300 pounds.
The machine is sturdy, with a few potential assembly problems when you are putting it together, and stands upright for easy storage—a task made simpler by the inclusion of built-in wheels.
Oral hCG Review: Yavonae Drops for Dr. Simeons - A Homeopathic Quick Weight Loss Diet?Submitted by Saadia on Tue, 07/20/2010 - 08:00
Homeopathy is favored by some - not by all - as is the case with all kinds of alternative medications and prescriptions in the market.
The makers of Yavonae Drops propose a weight loss formula based on the oral administration of the human chorionic gonadotropin, known as hCG. This may attract those who have been using hCG injections for the same purpose. Administration by mouth sounds far more convenient.


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Let's dig into the division mailbag.
BIG SLIM from FT. Washington, MD, writes: How do you think Baltimore Ravens safety Ed Reed will perform this year after coming off an injury-plague season?
James Walker: Reed is certainly banged up after hip surgery, and it appears he's going to wait until he 100 percent. When will that be? No one knows for sure. Reed recently estimated that he's about 35 percent, which means he has a long way to go. I don't anticipate him doing much, if anything, in training camp and the preseason. But if Reed misses regular-season games, I think the Ravens are deep enough to maintain.
Ken from Washington, D.C., writes: Do you think that the Steelers would have any interest in trading for Vincent Jackson if San Diego made him available?
Walker: Ken, Jackson wants a big contract extension and will be suspended for the first three games. I don't see that as a match for Pittsburgh. Plus, the Steelers believe they're fine at wide receiver. They have a lot of confidence that Mike Wallace will be able to step up in the starting role and that Antwaan Randle El is savvy enough to fill in the No. 3 role. Their biggest concern right now is filling the right tackle spot vacated when Willie Colon was lost for the season following his Achilles injury.
Ben from Cincinnati wants to know if the Bengals can re-sign cornerbacks Johnathan Joseph and Leon Hall to long-term deals.
Walker: Readers of this blog know that it's always hard for me to look beyond one year. The NFL is very much a year-to-year league, so I try to stick to that approach. Joseph is in the final year of his contract, and the Bengals are making an effort to sign him long-term. I'm told talks are early and there are no guarantees. But both sides are happy there's some positive communication. Hall has two years left on his deal, so he's not a primary focus for Cincinnati right now. But keeping both will be very expensive.
Dillon from South Dakota writes: How big of an impact FB/RB Peyton Hillis will make this year for the Browns?
Walker: Hillis was sick during mandatory minicamp last month so I didn't get to see how he fits in Cleveland's offense. Based on what I've seen in Denver, Hillis is tough between the tackles and could be a good fit. It looks like Montario Hardesty and Jerome Harrison will get a bulk of the carries. But Hillis should be able to carve out a role with Cleveland, perhaps in short-yardage situations.


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New York Sftwr Ind Assn, Services, listed under "Services" category, is located at 920 Broadway New York NY, 10010 and can be reached by 2124754503 phone number. New York Sftwr Ind Assn has currently 0 reviews.This business profile is not yet claimed, and if you are the owner, claim your business profile for free. If you are not the owner you can invite this business to join by email or by phone.Browse all Services in New York NY. Discover census data for New York, NY.
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New Orleans Jazz & Heritage Festival, Fairgrounds Racecourse, New Orleans, La. AP Photo
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Jazzfest crowd in New Orleans. It was the festival's Latin Day, featuring Juanes, Manuella, Julieta Venegas and others. AP Photo
April 24, 2005 |
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© Copyright 2017 KastOblivion. All rights reserved.
Status: Finished
Genre: Non-Fiction
Is this meant to be a short story? There's no narrative. No characterisation. Nothing.
This is awesome!!!! I totally agree!!! It's Nicely done:D I just wish more people would see this, because it IS really true. Great stuff.
Interesting topic, and one I myself have puzzled over many a time. I read an article in a recent edition of Philosophy Now, that gave me some food for thought. It was an allegory that likened Death to a dragon that terrorized a town, and it was really an interesting way of looking at death and immortality.
The link is here: http://philosophynow.org/issues/89/The_Fable_of_the_Dragon-Tyrant
I suggest you give it a quick read!
Book / Action and Adventure
Short Story / Fantasy
Short Story / Non-Fiction
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Latest Discoveries & Publications
New way of attacking Viruses The team behind the work was led by TBSI's Dr Nigel Stevenson, Assistant Professor in Immunology. They have discovered that a biological molecule (STAT3) is also critical in protecting us against infection. Journal: Cellular and Molecular Life Sciences Irish Times 26 January 2017 TCD press
Cover of the Royal Society of Chemistry publication Chemical Communications Collaborative work by TBSI's Eoin Scanlan, Thorri Gunnlaugsson (Chemistry) and Clive Williams (School of Biochemistry and Immunology). The work focuses on the development of fluorescent drug candidates that have sugar units attached to them. They can only be delivered into cancer cells upon selectively hydrolysed of the sugar (of a native glycosidic linkage) in situ by glycosides enzymes. paper .pdf 3.71mb Irish Times 8 December 2016
Understanding Inflammation The work is a joint collaboration between the Inflammation Research Group at TBSI, which is led by Professor of Biochemistry, Luke O'Neill, and the Medical Research Council Mitochondrial Biology Unit, Cambridge UK, which is led by Dr Mike Murphy. TCD Press Officer wrote
New study launched by Professor OFarrelly and her team to discover howsuper immune system can prevent hepatitis C Press Release TCD listen to RTE news at one
New hope for cornea transplants TBSI's Mark Ahearne and his team are confident that this research will generate new therapies to treat patients suffering from corneal blindness. Irish Indepentent life section
A new scanning technique with major implications for those at risk of developing bone diseases like osteoporosis has been created by a team of scientists. The research team was led by TBSIs chemistry professor Thorri Gunnlaugsson and Dr Esther Surender. Prof Gunnlaugsson said: The impact is long term as we still have to bring our discovery to the clinic but being able to determine bone quality really impacts everyone. The Irish Examiner reports. The Independent Article Read in full in Chem 08 September 2016 Volume 1, Issue 3 Press Office, TCD report
Welcome to the Fifth Anniversary Symposium, TBSI 5th September 2016
The Trinity Biomedical Sciences Building was opened by An Taoiseach Enda Kenny on 17th June 2011. On Monday 5th September TBSI celebrated its 5th Anniversary with a Symposium which reviewed it's progress, landmark research and future research directions. TCD's press office described the highlights. To mark the occasion TBSI also held an imagery competition#TBSI5 Programme Abstracts
TBSI's Kingston Mills leads the pre-clinical work in the project seeking next-gen whooping cough vaccines. The pan-European initiative PERISCOPE sets out to accelerate improvement of prophylactic vaccines and vaccination strategies for pertussis. The project is funded with a total budget of 28 million over the next five years by the Innovative Medicines Initiative (IMI), a joint undertaking of the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA). Additionally, PERISCOPE is the first IMI project to receive funding from the Bill & Melinda Gates Foundation. Read TCD's article
New Language for Cells: Ground-breaking study that merges linguistics, biochemistry, computer science and mathematics. Scientists, led by TBSI's Professor Gavin Davey, (with awards for funding for the interdisciplinary study provided by EU Marie Curie and Science Foundation Ireland) have written a formal language that enables deciphering of the highly complex manner in which proteins are modified by sugar molecules read more
Discovery by immunologists at TBSI has just been published in the journal Immunity. Professor in Immunology Ed Lavelle, from Trinitys School of Biochemistry &Immunology and AMBER - the Science Foundation Ireland funded materials science centre - and Dr Elizabeth Carroll have uncovered the mechanism by which a promising vaccine adjuvant, chitosan, induces an immune response. The Trinity teams discovery provides a roadmap to develop vaccines that trigger cell-mediated immunity. Read Trinity Communications Office's article Immunity Journal pdf 3.19mb
Congratulations to Ed Lavelle, Cliona Ni Cheallaigh and other members of the Lavelle and O¹Neill groups in TBSI on their recent paper in Immunity. "A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling". paper - (2.93 mb PDF)
Congratulations to the Membrane Structural & Functional Biology Group on the publication of their Paper in Science. "Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin Science. 19th February 2016
With antimicrobial resistance on the rise, the World Health Organization has advised that a post-antibiotic era, in which minor injuries and common infections can prove fatal, is looming. New drugs are needed. Globomycin attracted attention as an antibacterial candidate because of the novel peptidase, LspA, it inhibits and the many lipoproteins with critical roles in bacterial physiology, pathogenicity and antibiotic resistance that go unprocessed as a result. The high-resolution structure of LspA inhibited by globomycin reported here can now be used for the design of better globomycin analogues, to explore the thousands of inhibitors developed for other peptidases, and to design entirely new and more effective antibiotics.
Congratulations to the Membrane Structural & Functional Biology Group on the publication of their article in Nature Communications "Ternary structure reveals mechanism of a membrane diacylglycerol kinase Nature Communications. 17th December 2015. Diacylglycerol kinase is a small, integral membrane enzyme that catalyses a complex reaction involving substrates with widely contrasting solubilities. Its lipid substrate is hydrophobic and resides in the membrane while its co-substrate, ATP, is entirely water soluble. How this diminutive nanomachine, less than 10 nanometers tall, brings these two disparate substrates together at the membrane interface for reaction is revealed here in a molecularly detailed crystal structure. As the smallest known kinase, most of its bulk is devoted to creating substrate binding sites. This new structure, solved with the aid of free-electron laser X-rays, contributes to explaining 50 years of work on a paradigmatic enzyme. (PDF 4.21 MB)
Non-Disease Proteins Kill Brain Cells. Congratulations to TBSI's Ken Mok (Associate Professor in Biochemistry) and Gavin Davey (Associate Professor in Neuroscience) who along with several young researchers including Níal Harte and Igor Klyubin, collaborated with Professor of Neuropharmacology, Michael J Rowan, Professor in Chemistry, Principal Investigator in CRANN and Dean of Research, John Boland to complete the research . Dr Kenneth Hun Mok (pictured here) led the study that was published in the Journal of Biological Chemistry (pdf) on Friday 20 November 2015.
News & Events
TRAining in Cancer mechanisms and Therapeutics (TRACT) Congratulations to TBSIs Dr Daniela Zisterer (project coordinator) and colleagues in the School of Biochemistry & Immunology and School of Dental Science who, along with European partners Queens University Belfast, University of Siena, University of Valencia and OROBOROS INSTRUMENTS, have been awarded 2.9 million for research into oral and oesophageal cancer. This project, entitled TRAining in Cancer mechanisms & Therapeutics (TRACT), has received funding from the European Unions Horizon 2020 research & innovation programme under the Marie Sklodowska-Curie grant agreement No. 721906.
Wellcome Health Research Board Irish Clinical Academic Training (ICAT) programme. ICAT is an exciting new all Ireland clinician PhD programme funded by Wellcome and the Health Research Board, HSE-NDTP; HSC R&D Division; and six Universities; TCD, UCD, NUIG, QUB, RCSI and UCC. The programme is coordinated by Molecular Medicine Ireland. Integrated with postgraduate medical training, ICAT will support 4 years of academic training at the beginning of higher specialist training (HST) or equivalent, with clinical and academic mentoring until completion of PhD and CCST/CCT. ICAT now seeks to appoint the first cohort of 8 well qualified and ambitious medical graduates who aspire to become the next generation of clinical academic leaders. Web link for further details Advert poster pdf 740kb
New Company: Inflazome to tackle chronic inflammatory diseases. The intellectual property is based on the Science Foundation Ireland-funded research. Luke ONeill and his team initially discovered that a known molecule seemed to suppress the target inflammasome. In collaboration with Professor Cooper, the team developed and subsequently patented new therapeutic inhibitor compounds based on this molecule. These compounds are now being developed by Inflazome and hopes are high that they might be useful new treatments for a range of inflammatory diseases. TCD Press Office report read the Irish Times Tue, Sep 13, 2016 Business Section
Congratulations to TBSI PIs who secured prestigious SFI awards
Wellcome Image Awards 2016 - The winning images have arrived in TBSI. These wonderful images can been seen in the Lobby. These images were on display to celebrate the 5 year anniversary of TBSI's opening. Details here
TBSI'S Luke ONeill, is one of five academics worldwide to join a new immunology research collaboration programme operated by the global healthcare company, GSK. The Immunology Network hosts global experts to set up research labs called the Immunology Catalyst. Details here
Congratulations to Professor Luke ONeill who has been elected as a Fellow of the Royal Society, where scientists are elected to the Fellowship by their peers as recognised leaders who have advanced their fields through their ground breaking work. Prof ONeill has made many contributions to improved knowledge of how the human body works including metabolism, the immune system and cell signalling. He is Professor of Biochemistry in the School of Biochemistry and Immunology in Trinity College Dublin and is a leading researcher in the school and in the Trinity Biomedical Sciences Institute (TBSI), where he was the first Academic Director.News and Events prior to those listed above


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Welcome to WorldWeb.com!Whether you are planning a romantic getaway, weekend retreat or an adventure of a lifetime, WorldWeb.com's more than 500,000 webpages of travel information will help you every step of the way.
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Tourist Attractions
Built in 1937 at a cost of $35 million, this bridge is more than a mile and a half long, and was built to connect San Francisco with Marin County.
Location: San Francisco, California
Hotels & Motels
Following the 1906 earthquake, the Fairmont San Francisco underwent a $72 million renovation project to return it to its previous appearance.
Location: San Francisco, California
Tour Operators
Widely-considered the country's premier ski destination, Vail is reputed to have the most extensive high-speed lift system in North America, along with one of the highest elevation gains of 3,450 ft (1,052 m).
Location: Vail, Colorado
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Looking for something to do in ? Check out these current and upcoming events. If you know of an event that is not listed in the travel guide, please feel free to add an event listing (it's free).
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Wellness Centre
Online bookings let you pick date/time for your visit.
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At Mollington Grange Wellbeing Centre, our aim is to exceed all expectations. We provide a range of treatments tailored to the needs of the individual with the overall aim of improving total wellbeing. As well as holistic treatments, we also offer a range of beauty treatments such as manicures, pedicures, facials, microdermabrasion, anti-cellulite treatments, Xtreme semi-permanent eyelashes and facial threading.
We believe that when people are centred, happy and healthy, natural beauty can shine through. Our range of holistic therapies, such as massage therapy, reiki and reflexology can help reduce stress, promote health and encourage wellbeing. The stresses and strains of modern day life can leave people burnt out and exhausted. It is our aim to help clients take time for themselves to relax, rejuvenate or pamper themselves.


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H-E-B Fuel, gas station, listed under "Gas Stations" category, is located at 2955 South Gulf Freeway League City TX, 77573 and can be reached by 2813375142 phone number. H-E-B Fuel has currently 0 reviews.This business profile is not yet claimed, and if you are the owner, claim your business profile for free. If you are not the owner you can invite this business to join by email or by phone.Browse all Gas Stations in League City TX. Discover census data for League City, TX.
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To hear the pundits tell it, Bernie Sanders' campaign is on its last leg. But if Bernie's February fundraising totals are an indicator, the political revolution Sanders is calling for has begun.
As of this writing, Bernie Sanders is on target to raise over $42 million for the month of February. This morning, the Vermont senator originally set a goal of $40 million by 11:59 PM Pacific Time after announcing that his campaign had already raked in $36 million between February 1 and February 28. The campaign reached the $40 million goal shortly after 8 PM Eastern Time. According to the Sanders campaign, nearly $42 million has been raised by 1.4 million individual contributions, meaning the average contribution was approximately $30.
This equates to over $6 million raised in one day on the heels of Sanders' crushing defeat in South Carolina. The one-day total is nearly as much as Sanders raised in the aftermath of his decisive win in the New Hampshire primary in early February, when the Sanders campaign raised $6.4 million in one day. While the Hillary Clinton campaign hasn't yet disclosed its February fundraising total, it's likely Sanders will have outraised the former Secretary of State for the second consecutive month. In January, Sanders raised nearly $5 million more than the Democratic front-runner, largely from a wave of small donations.
A recent Los Angeles Times article showed that some within the Democratic party were doubtful of Hillary Clinton's fundraising viability if the nominating contest lasted late into the Summer, as the former First Lady and New York senator is already on the verge of tapping out her fundraising base. Many of her donors have already given the maximum $2700 donation one can give throughout the course of an election year.
"The pond is getting fished out. Everyone is sending invitations to the same group of people. And those people have already given as much as they are allowed to give," an unnamed Clinton bundler from Los Angeles told the Times.
Democratic voters in 12 states will vote tomorrow on Super Tuesday, where a large portion of delegates are up for grabs.


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North Carolina added jobs last month, the first employment gains the state has seen since August, the N.C. Employment Security Commission said.
North Carolina added jobs last month, the first employment gains the state has seen since August, the N.C. Employment Security Commission said.
In a report released Friday, the ESC said the state gained 2,300 jobs in December. But losses in the construction sector offset the job gains, as North Carolina's unemployment rate went up slightly to 9.8 percent in December from 9.7 in November.
Still, ESC Chairman Lynn R. Holmes pointed to the additional jobs as a positive sign for the state's workers and those looking for work.
"Over the past year, there was a gain of 10,400 jobs, with many of the job sectors experiencing gains," he said. "Consistent growth throughout these sectors will be the key to gaining back jobs lost during the recession. The focus on job growth continues to be a high priority for the state's work force development team."
The bulk of the workers added to the rolls last month were in the professional and business services sector, the ESC said. Administrative jobs, especially positions obtained through temp agencies, accounted for much of the improvement in the professional and business sector, said Larry Parker, a spokesman with the ESC.
"That's a good thing because although people are working temporarily, they're still working, and it shows a lot of hope that many of them will end up in permanent jobs through these temp agencies," he said. "Another surprising thing has been the increase in manufacturing jobs, which has staged something of a comeback."
Construction continues to suffer, however, as the state lost 3,900 jobs in that sector, accounting for the largest employment decrease in December, Parker said.
Hendersonville ESC Manager Marilyn Williams agreed.
"We are seeing more manufacturing coming in. ... That trend seems to be in place for Henderson County," she said. "We are also seeing sluggish listing of orders for construction, due to the slow housing market, so locally we are mirroring what the state is seeing. But at this time of the year, construction is traditionally slower anyway. You can't do it in the snow, I guess."
The state's unemployment rate is actually down from a year ago. The unemployment rate for December 2009 was 10.9 percent, the ESC said.
Unemployment in the state during 2010 peaked in February, with a jobless rate of 11.2 percent.
The ESC's report on unemployment throughout the state's 100 counties is set to be released Feb. 1.


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VW Rejection Shows UAW Share of U.S. Carmaking SlumpingTim Higgins
The United Auto Workers' failure to organize employees at an assembly plant in Tennessee operated by Germany's Volkswagen AG underscores how the union's members are building a smaller share of vehicles made in the U.S.
The CHART OF THE DAY shows that the number of cars and trucks produced by UAW workers declined to 54 percent of all vehicles in 2013 from 86 percent 15 years ago, as overseas automakers build more vehicles in the U.S.
UAW workers assembled 5.91 million of the 10.9 million cars and trucks made in the U.S. last year, according to the Center for Automotive Research in Ann Arbor, Michigan. In 1999, union workers accounted for 10.8 million of 12.6 million vehicles, according to data from the center and LMC Automotive.
Organizing the U.S. factories of Asian and European automakers is critical to the future of the union, where membership has fallen 75 percent since 1979. The UAW has twice failed to win votes to represent workers at Nissan Motor Co.'s Smyrna, Tennessee, factory.
The declining share weakens a union's hand at the bargaining table. In 1965, about 95 percent of vehicles made in the U.S. were assembled by UAW labor, Art Wheaton, a workplace and industry education expert with Cornell University, said.
"If you've got 95 percent, then life is a little easier because everyone is paying a similar rate, a similar situation," Wheaton said in a telephone interview.
Workers at Volkswagen's Chattanooga, Tennessee, plant voted 712-626 last week against joining the UAW after an organizing campaign that attracted opposition from elected officials, such as Senator Bob Corker and Tennessee Governor Bill Haslam, both Republicans.
As "union density decreases" so does the ability to negotiate, UAW said on its website. "In order to win back the sacrifices that we've had to make, we need to reorganize industries where we represent members," the Detroit-based UAW said.


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Accor, Australia's largest hotel operator has enjoyed a long standing partnership with Mission Australia, helping to improve the lives of those less fortunate, with a focus on combating homelessness.
Since 2011, Accor's annual 'Race to Survive' event has been bringing together their hotel employees from across Australia to compete in a three-day adventure race, while raising funds to support Mission Australia services.
In just two years Accor employees have raised $2million to support Mission Australia services including:
In addition to Race to Survive, Accor works closely with Mission Australia's Charcoal Lane program, providing support and employment opportunities for Indigenous youth. They also support Missionbeat which helps break the cycle of homelessness by transporting homeless adults and children, and intoxicated or drug affected men and women to services to enable them to meet their immediate needs. This includes safe accommodation, medical care, food and clothing or, as a last resort, a blanket or a street swag.
Mission Australia would like to thank Accor for their long term commitment to standing together with us to help Australians in need.
More information about partnerships
To explore a partnership with Mission Australia, or for more information on how we work together with Australians in need as they move towards independence please contact us at email@example.com
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Founding Purpose - 'Inspired by Jesus Christ, Mission Australia exists to meet human need and to spread the knowledge of the love of God'


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Renowned for their MTB bars, NC-17 now bring you a trekking handlebar. You name it, they have it.
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Posted by ppasche on 04/15/2015 11:11pm CDT
NEW YORK (AP) — Reggie Jackson had 24 points and 11 assists and the Detroit Pistons closed out the season with a 112-90 victory over the New York Knicks on Wednesday night. Andre Drummond and Kentavious Caldwell-Pope each had 17 points for Detroit.
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'Twilight' DVD Among the Top Five Best First Day Releases
Having generated a phenomenon since its release on November 21, 2008 with a $373.3 million worldwide sales, "Twilight" got out to a great start on its DVD sales. Launched on Saturday, March 21, 2009, the DVD version of the vampire drama has been sold for more than 3 million on its first day only, as claimed by Summit Entertainment.
With the impressive bow, the movie starring Kristen Stewart and Robert Pattinson has been listed among the top five best first day DVD releases over the past two years. It joined other best-selling movies in DVD, like "Pirates of the Caribbean: At Worlds End", "The Dark Knight", "Harry Potter and the Order of the Phoenix" and "Transformers".
"TWILIGHT at Midnight" event was thrown across the country by Summit Entertainment and retailers for this DVD release. Drawing big crowds, some saw surprise appearance by filmmaker and cast. Rachelle Lefevre who plays Victoria came up in Salt Lake City and Ashley Greene who plays Alice Cullen attended the Los Angeles event, while director Catherine Hardwicke showed up in Dallas. In addition to the three, Edi Gathegi and Nikki Reed have also met the fans in New York and Chicago respectively.
"We are incredibly appreciative that TWILIGHT fans came out to once again support this film at our midnight events across the nation," said Steve Nickerson, Summit's President of Home Entertainment. "With such a successful first day sales, it is apparent that our fans remain passionate about the TWILIGHT SAGA and want to own a piece of the Edward and Bella story they have come to love. We look forward to the continued success for both the home entertainment and retail sales of this property as a whole."
- 'The Voice' Season 12 Sneak Peek: Watch 29-Year-Old J. Chosen Blow the Coaches' Mind
- Sinead O'Connor Apologizes for Saying Arsenio Hall Gave Prince Drugs
- See Lethal Charlize Theron in New 'Atomic Blonde' Poster
- Brooklyn Beckham Gets Dating Advice From Anais Gallagher
- Nicole Scherzinger Goes Underwear Free in Dazzling Dress at BRIT Awards After-Party
- 'This Is Us' to Bring Back Ron Cephas Jones in Season 2 After That Emotional Road Trip
- Gigi and Bella Hadid Go Vampy for Milan Fashion Week
- NBC's 'Taken' Opening Scene Reveals How Bryan Mills' Sister Is Murdered


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R.A. Dickey delivered a complete game to pick up his 17th win and Ike Davis produced a two-run homer as the Mets beat the Miami Marlins, 3-0, Friday night.
Cincinnati's Johnny Cueto, Washington's Gio Gonzalez and Dickey share the major league lead in wins. Dickey's 190 strikeouts rank second in the NL, two behind the Dodgers' Clayton Kershaw. The knuckleballer's innings count (191 1/3) also trails only Kershaw (192 2/3) in the league. Dickey's third shutout this season is the most by a Met since David Cone produced five in 1992.
Jeremy Hefner (2-5, 4.65 ERA) opposes right-hander Josh Johnson (7-11, 4.00) today at 7:10 p.m.
It does not quite set up meaningful games in September, but the Mets (62-70) trail Philadelphia (63-69) by a game for third place in the NL East. The Amazin's have opened a three-game cushion on cellar-dwelling Miami (59-73).
Saturday's news reports:
• Catcher Mike Nickeas and corner infielder Zach Lutz are due to rejoin the Mets today in Miami, as rosters expand. Collin McHugh will return to face the St. Louis Cardinals on Labor Day at Busch Stadium. The Mets have not yet announced the remainder of the contingent, but Jordany Valdespin, Jenrry Mejia, Jeurys Familia and Elvin Ramirez would be expected to be promoted after Triple-A Buffalo's season ends Monday at Lehigh Valley. The Mets also could reward a veteran such as Matt Tuiasosopo or Fred Lewis. Wally Backman is expected to join the Mets' coaching staff for the next homestand, which begins Friday against the Atlanta Braves. Read more in the Record.
• Dickey is now 4-0 with a 1.16 ERA against the Marlins this season. "When he makes his speech for Cy Young Award, make sure he mentions the Marlins, please," Miami manager Ozzie Guillen told reporters postgame. Read Saturday's game recaps in the Post, Times, Star-Ledger, Newsday, Record and Daily News.
• Josh Thole went 0-for-3 and is now hitless in his past 28 at-bats. The Mets had recently tried to change Thole's approach at the plate to have him produce more power, but they have abandoned that attempt and instructed Thole to revert to his gap hitting while choking up on the bat. Read more in the Star-Ledger and Post.
• Wilmer Flores and Allan Dykstra had consecutive homers as Binghamton beat Trenton, 8-5. St. Lucie notched its 81st win, tying the club record, originally set in 2000 by a team that included Heath Bell and Endy Chavez. Brooklyn's Hansel Robles upped his streak of innings without allowing an earned run to 36 and Alex Sanchez homered off rehabbing Pedro Feliciano in a 5-1 win against Staten Island. The Cyclones remained a game ahead of Batavia for the New York-Penn League wild-card lead. Read Friday's minor league recap here.
• Mike Pelfrey, who lives in Wichita, Kansas, is due to visit the Mets during the next leg of their trip, in St. Louis. Pelfrey recently resumed throwing. He underwent Tommy John surgery on May 1. Pelfrey is likely to be non-tendered in December because he is making $5.6875 million this season and is eligible for arbitration. The collective bargaining agreement requires him to make at least 80 percent of that amount if he is not cut loose.
• The Mets spent the most per win in Major League Baseball over the past five seasons, with only the Minnesota Timberwolves and St. Louis Rams less efficient in all of the major sports, according to Business Week.
TRIVIA: Which Met had the team's first homer at first-year Marlins Park?
Friday's answer: Jose Reyes' first hit against the Mets came in his only hit during a 1-for-12 series at Citi Field in April. Reyes singled against Jon Rauch.


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Bacon And Twice Baked Potatoes
|Baking potatoes
|4 Medium
|Bacon slices
|2 Tablespoon
|Grated cheddar cheese
|1⁄2 Cup (8 tbs)
|Sour cream
|1⁄3 Cup (5.33 tbs)
|Half and half
|1⁄4 Cup (4 tbs)
|Thinly sliced scallions
|1 Tablespoon
|Chopped fresh parsley
|2 Tablespoon
|1⁄2 Teaspoon
|White pepper
|1⁄8 Teaspoon
|1 , beaten
1. Pierce potatoes with a fork at both ends after washing them.
2. Microwave at Power Hi for 16 to 18 minutes or such that potatoes are tender.
3. Between layers of paper towels keep the bacon and microwave at Power Hi for 2 to 3 minutes or until just crisp.
4. Cool, crumble and set aside.
5. From top of each potato cut a strip about 2 1/2 inches wide.
6. Scoop out centers to within 1/4-inch of edge and reserve shells.
7. In large mixing bowl, combine potato pulp, reserved bacon and remaining ingredients.
8. Using an electric mixer beat at medium speed until blended.
9. Spoon one-fourth of the potato mixture into each shell.
10. Preheat oven to 350°F.
11. Arrange filled potatoes in a glass baking dish.
12. Cook at Convection (350°F) for 15 minutes, or until hot.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 329 Calories from Fat 159
% Daily Value*
Total Fat 18 g27.7%
Saturated Fat 10.7 g53.7%
Trans Fat 0 g
Cholesterol 100.6 mg33.5%
Sodium 402.4 mg16.8%
Total Carbohydrates 34 g11.2%
Dietary Fiber 2.6 g10.5%
Sugars 2 g
Protein 10 g19.5%
Vitamin A 25.7% Vitamin C 34.8%
Calcium 18.2% Iron 12.8%
*Based on a 2000 Calorie diet


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Communications professional & media scholar
Hey there. I'm a media and communications professional currently living in Boston. I'm interested in media research and strategy, and have a background in cultural theory, digital identity, media relations, and multimedia production. I have experience across media platforms - from radio to film criticism and strategic web design - and enjoy soaking up knowledge from those around me as an instructor, a researcher, and a PR professional. I love talking comm and making things happen. Get in touch!


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Microsoft Project 2013 is one of the most widely used project management softwares available today. Full of powerful features to help make work easy, MS Project forms the primary choice of project managers all across the world.
Build your competency on Microsoft Project software by attending the MS Project 2013 workshop by one of the leading Microsoft Silver Learning Partners in India, KnowledgeWoods Consulting.
Why Attend this Workshop?
- You'll be trained on the latest version of the MS Project software
- Will make you strong enough to use MS Project software towards managing the most complex of your projects
- You'll earn a certificate for yourself which will be an added advantage in your candidature
- You'll gain practical knowledge on the most sought after and the most popular project management softwares that are available till date
- Will raise the level of your Employability
- Will provide better insight into various aspects of your project
Program Highlights:
- Proven Learning Model based on Blooms Taxonomy
- Sessions by Experienced Industry Experts
- Easy-to-attend weekend classes
- Program enrollees are provided with Pre-Training Material for ease of understanding
- Participants are equipped with Microsoft Project 2013 Handbook for their personal reference
- Upon completion, participants receive 15 Contact Hours/PDUs Certificate
- Includes Module Wise Hands-on Lab
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All his long career, Stephane Grappelli maintained an effortless balance between art and entertainment. He was one of the last of the classic musician- performers, for whom playing jazz was inseparable from playing for people.
Born in the Paris of the belle epoque, Grappelli lost his mother before he was five. He was raised by his loving but impecunious father, who placed him in the experimental school run by Isadora Duncan, where an orchestral performance of Debussy's Prelude a l'Apres-midi d'un Faune gave him his first deep musical impression. The coming of the First World War, however, shunted him into squalid orphanages and, sometimes, hand-to-mouth existence on the streets. Grappelli often described his childhood as "like a Dickens novel", and it made him a lifelong survivor. Ever after he would be, as he said, "a bit careful" with money - what others might call parsimonious - and he was always aware of the spectre of poverty. At the same time he never lost a grateful delight in the pleasures of life, an outlook reflected in his joyously spontaneous playing.
He began to play for his living after the war at the age of 12, busking in courtyards with a junior-size violin. He taught himself the fiddle, though, with characteristic diligence, he took a course in solfeggio and harmony at the Paris Conservatoire, and at 15 got a job in an orchestra accompanying silent films. Shortly afterwards came his overwhelming exposure to the new American music, on a primitive juke-box. He knew instantly this was what he wanted to play. "I felt I was born with jazz" - and he sought out fellow enthusiasts and records by his first heroes, Armstrong and Beiderbecke.
Finding work as a jazz violinist hard to come by, Grappelli made himself a second career as a pianist. He played both instruments with Gregor and his Gregorians in the late Twenties and Thirties, and even doubled for a while on alto saxophone. His first meeting with Django Reinhardt came in 1931, but it wasn't until 1934, during intervals at the Hotel Claridge's the dansant, that the legendary Quintet of the Hot Club of France was born.
Records like "My Sweet" and "Minor Swing" established them as the first European group worthy of comparison with the Americans. Grappelli's wiry lyricism perfectly complemented Reinhardt's dominant, angular attack, though, on a personal level, the guitarist's wilful gypsy ways often exasperated his scrupulous partner.
Grappelli's long, happy association with Britain (which he called his "second country") began inadvertently and inauspiciously when he was stranded in London at the beginning of the Second World War. Landing on his feet as usual, he built up a considerable public following through his work with Hatchett's Swingtette in the West End, broadcast and toured extensively with his own groups, and forged a stimulating musical partnership with the young George Shearing.
The success and security he had won in Britain made him reluctant to renew his chequered alliance with Reinhardt after the war's end. Apart from a few records and tours with the old line-up, they went their separate ways, Grappelli opting for a full if relatively uneventful life playing a variety of music for a variety of audiences. He carried on in the same fashion when he returned to France in 1954, respected by the younger generation of beboppers as a "monster musician" always interested in new developments, but taken for granted by the general public. In terms of recognition, his sturdy professionalism worked against him, denying the attention his ever-ripening jazz talent deserved.
This benign neglect persisted into the 1960s, increased by the onset of rock and free jazz, two developments alien to Grappelli's otherwise catholic taste. In 1967 he accepted a residence at the Paris Hilton and remained there until 1972, surrounded by diners and dancers, while concerts and recordings made it clear he was playing better than ever.
Part of his decision to leave the Hilton was due to his famous appearance on Michael Parkinson's television show with Yehudi Menuhin, in December 1971, which led to a sequence of celebrated duets. But part of it was simple boredom, his realisation that, as he said, "it is stupid to stay in one place for so long".
Going back on the road, he was soon active in many more places than he'd been before. In 1973 the guitarist Diz Disley reunited Grappelli with the guitar and bass accompaniment of the Hot Club days and introduced him to a vast and enthusiastic audience of young people, who were captivated by his natural, fatherly effervescence, after the psychodramatics of rock. Grappelli's huge success with the Disley trio at the 1973 Cambridge Folk Festival inaugurated his rise to international fame, which expanded throughout the Seventies, and continued until his death.
The Grappelli style was unmistakeable. His sometime protege Nigel Kennedy called it "the most like speech of almost any musician working today". On a ballad like "The Folks Who Live on the Hill", he was tenderly eloquent, on medium-tempos such as "Sweet Georgia Brown" unfailingly swinging, while up-tempos like "Them There Eyes" shone with agile and exhilarating energy.
On any tune he treated the melody with imagination and respect. Like many musicians of his generation he believed that a melody line had its own value, as much as an improvisation, and by colour and nuance he could turn a familiar theme into a personal statement. The purity of his music and sincerity of his manner gave Stephane Grappelli's concerts a classic quality. They were wholly free from hype and gimmicks - except perhaps for his flowered shirts. At one Grappelli concert I overheard a father- son exchange, the son observing that, though he liked the music, a rock show would use lights and such for extra stimulation. "Oh crazy, man," said his father sardonically, "you mean you have to listen." That seemed to sum up Grappelli's timeless appeal, which made simply listening a pleasure.
Happily that quality comes through on his many recordings, though it's fair to say he recorded too much and sometimes too casually, putting his formidable technique on automatic pilot. As a committed public performer, he felt deprived of audience contact in the studio. But there are plenty of sparkling moments in his scores of record with an astonishing array of partners, from Duke Ellington to Menuhin, Earl Hines to Gary Burton. And there are the great performances with Django Reinhardt. They were ideal foils for each other, and you can already hear in Grappelli's playing the gifts that became richer and more assured throughout his life - the fluency and invention, warmth and grace that made him one of the best- loved communicators in jazz.
- Geoffrey Smith
The partnership between Grappelli and Reinhardt was often precarious and yet it was both fundamental and important to the violinist's career, writes Steve Voce. He acknowledged this when, in the decades after the death of the guitarist, Grappelli would have an empty chair placed on stage "for Django".
The two were the first to prove that Europeans could match and often better the American musicians at playing jazz. But the pairing was grotesque. Grappelli was educated and played with a classically trained sophistication. Reinhardt lived in a caravan. "Django was a gypsy who had burnt his hand in a caravan fire and only had three fingers," the tenorist Flip Phillips recalled. "All he could steal was bowling balls." Because of his reformed hand Reinhardt had developed an unorthodox guitar technique which to some extent matched his character.
Grappelli was reliable and businesslike. Reinhardt had no care for time- keeping and was generally erratic in his behaviour. "Django was always late and often he forgot to appear at night because his only clock was the sun," said Grappelli. Reinhardt was also illiterate, though he taught himself to read later. The guitarist, who trusted his senior partner implicitly, was sensitive about his inability to read and would pretend to check contracts after Grappelli had approved them. On one occasion he pretended to read a contract the two were being offered by a promoter for a booking in London. To make his charade convincing he pointed to a line in the contract and said that it was unacceptable. Furious, Grappelli took the paper from him and read the line. It was to guarantee the two first-class return airfares to England.
The violinist disliked flying and because of this postponed his first visit to the United States until 1969 (Reinhardt's death in 1953 had forestalled a planned trip to New York by the duo). He first played at Carnegie Hall in 1974 and returned there to celebrate his 80th birthday in 1988 with a concert which teamed him with the cellist Yo Yo Ma, the Juilliard String Quartet and a distinguished assembly of American jazz musicians.
Grappelli's instrument is barely compatible with most jazz combinations, but this iconoclast of the violin played with and sometimes recorded with such diverse jazz characters as Miles Davis, Duke Ellington, Gary Burton, Oscar Peterson, Earl Hines and Phil Woods, to say nothing of his albums with Yehudi Menuhin and Yo Yo Ma. His playing continued to improve as he gave concerts in the Nineties and his recording career, which stretched over seven decades, is probably the most formidable in the whole of jazz.
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Vitabiotics capsules contain a unique high purity marine oil formula that conveniently provides the benefits of both Omega-3 fish oil and Cod liver oil in a 50/50 ratio. The high-grade oils used provide rich sources of the essential fatty acids, DHA (Docosahexaenoic acid) and EPA (Eicosapentaenoic acid). Omega-3 fatty acids are essential because although they can be made in the body, their conversion from other fatty acids is not very efficient. Vitabiotics 2-in-1 fish oils therefore provide a valuable dietary source. Cod liver oil additionally provides a rich natural source of vitamin D. Vitabiotics 2-in-1 capsules contain vitamin E, an important natural antioxidant, which also helps to protect the marine oils. - No artificial colours; - Molecular distillation purification process; - No starch or gluten; - No preservatives; - No sugar, salt or yeast; - A rich source of Omega-3 fatty acids (EPA & DHA); - A natural source of vitamin D; - Vitabiotics 2-in-1 is not tested on animals; - To help prevent any aftertaste, Vitabiotics 2-in-1 capsules have pioneered an orange flavoured odourmask shell.
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If you are looking for a home theater receiver that bridges the gap between midrange and high-end, consider the Yamaha AVENTAGE RX-A1060.

With great performance, and an abundance of features, the RX-A1060 can serve your home theater receiver needs for a long time.

This receiver incorporates 7 channels of built-in amplification, is rated to deliver 110wpc, and features extensive standard and high-definition Dolby and DTS audio decoding and processing options, including Dolby Atmos (5.1.2 channel configuration) and DTS:X, as well as Yamaha's own audio processing enhancements. Audio processing is also further supported by the inclusion of ESS Technology SABRE Digital-to-Analog Audio Converters.

Audio connectivity, in addition to HDMI, includes both digital optical/coaxial, and analog input options, as well as two subwoofer outputs, and both powered speaker outputs or preamp outputs for an additional Zone. The RX-A1060 even provides 7.1 channel analog preamp outputs so that you can connect it to several combinations of external amplifiers.

To make speaker setup easy, the receiver has a built-in test tone generator that works in conjunction with a provided microphone and internal firmware (YPAO) that determines the size, distance, and frequency profile for each speaker and determines optimum output levels for your room.

For video support, the RX-A1060 has eight 3D, 4K, HDR-compatible HDMI inputs, two independently configurable HDMI outputs, along with 3D, 1080p, and 4K support.

The RX-A1060 also allows wired or wireless (via ethernet or built-in Wifi) audio streaming from other devices, such as a PC or media servers connected in a home network.

Extra bonuses include Wifi Direct/Miracast, iPod/iPhone connection via USB, along with Apple AirPlay, Internet Radio (including Pandora, Rhapsody, Spotify, and Sirius/XM), Wireless Bluetooth (Which allows direct streaming from compatible portable devices), and MusicCast compatibility.

Also, although the RX-A1060 does come with its own remote control, it can also be controlled conveniently by an iOS, Android, or Kindle Fire device.

Read My Full Report

The Onkyo TX-NR757 is a home theater receiver definitely worth checking out. First, up, the NR757 is THX-Select 2 Plus Certified, which means that is best suited for rooms where the seating distance from the screen is 10 to 12-feet. Of course, this only a guideline, as there are also a lot of other factors to take into consideration, such as total room size and room acoustics.

Audio support includes both Dolby Atmos and DTS:X audio decoding capability which expands the home theater listening experience in full 3 Dimensional, immersive surround sound.

In addition, for content that is not Dolby Atmos and DTS:X encoded, the TX-NR757 features the Dolby Surround Upmixer and DTS Neural:X processing that allows non-encoded audio content (such as current DVD and Blu-ray content), to be "upmixed" to the Dolby Atmos and DTS:X environments.

However, if you don't want to partake in the Dolby Atmos or DTS:X experience, there is still a lot to take advantage of that make TX-R757 worth the price.

For video, 3D and 4K pass-through compatibility is provided, as well as incorporate analog-to-HDMI video conversion, and 1080p to 4K video upscaling. HDMI 2.0 compatibility is also included which provides support for HDR-encoded content, such as the Ultra HD Blu-ray Disc format.

The TX-NR757 also provides iPod/iPhone and Apple AirPlay, GoogleCast, FireConnect By BlackFire Research, DLNA certification, and internet access to several online music content services. Network and internet connection access can be done via standard Ethernet or WiFi. Built-in wireless Bluetooth capability is also provided making it easy to stream audio content from compatible portable devices.

Note For Vinyl Fans: There is even good ol' fashioned phono input for listening to vinyl records (turntable required).

Read Full Review

The AVR-X2300W InCommand home theater receiver combines very good audio and video performance with an abundance of up-to-date features, and the price isn't bad either.

On the audio side the AVR-X2300W provides up to a 7.2 channel speaker configuration supported by Dolby TrueHD/DTS-HD Master Audio decoding, with the added bonus of including both Dolby Atmos and DTS:X Decoding capability.

You can also send select audio sources connected to the AVR-X2300W to a two-channel Zone 2 system, with the use of an external amplifier.

The AVR-X2300W is rated at 95wpc (.08% THD - measured at 20Hz to 20kHz with 2 channels driven with an 8 ohm load).

For video, this receiver provides 8 (7 rear and one front) HDMI inputs, with 3D, 4K (up to 60Hz), expanded Color Gamut and HDR (High Dynamic Range) pass through, as well as 1080p and 4K upscaling. .Also, two parallel HDMI outputs are provided that allow you to display the same images on two displays (or a display and a video projector) at the same time.

The AVR-X2300W also includes both network and internet streaming access (including (vTuner, Pandora, Sirius XM, and Spotify), via either Ethernet connection or built-in WiFi. In addition, built-in wireless Bluetooth and Apple AirPlay are included.

Marantz SR5011 Network Home Theater Receiver might be a great choice for your home theater setup. First off, besides the unusual front panel styling, this receiver provides up to a seven channel speaker configuration, including the ability to connect two subwoofers via preamp outputs, Dolby Atmos (5.1.2 channel configuration) and DTS:X decoding capability for a fully immersive surround sound experience.

For video, the SR5011 provides 8 HDMI inputs (7 rear/1 front) and 2 HDMI outputs that support 3D, 4K, HDR, and Wide Color Gamut pass-through, as well as analog to HDMI video conversion, and both 1080p and 4K upscaling.

Another feature worth noting is the inclusion of both 5.1/7.1 channel analog audio inputs and preamp outputs, which is becoming more rare these days, even on some higher-end receivers. Also, for added connection convenience, the speaker terminals are color coded by channel and widely spaced across the bottom of the rear panel.

Besides audio and video, the SR5011 also provides media player and networking functions with USB ports, DLNA certification, and internet access to music streaming services, such as Pandora, Sirius/XM, and Spotify. Apple AirPlay compatibility is also provided, so you can stream music from your iPhone, iPad, or iPod touch as well as from iTunes libraries. Also, wireless Bluetooth capability is included for direct streaming from compatible portable devices.

The above description is just the tip of the iceberg, the Marantz SR5011 is probably most flexible home theater receiver priced less than $1,000 - definitely worth checking out.

Read Full Review

The VSX-LX101 and VSX-LX301 Home Theater Receivers are two entries in Pioneer's Elite line that are very affordable.

Both receivers share a solid audio and video features, as well as incorporating cutting edge functions for today's digital content sources.

On the audio side, the LX101 and LX301 provide Dolby TrueHD/DTS-HD Master Audio, Dolby Atmos decoding (5.1.2 channel configuration), and DTS:X can be added via free firmware update.

In addition to home theater surround decoding and processing, both also provide Hi-Res audio playback via the home network, smartphone/tablet, or direct USB connection. Compatible Hi-Res audio files include Apple Lossless (ALAC), WAV, FLAC, AIFF, and DSD (2.8 MHz).

For ease of setup, Pioneer includes its MCACC system for calibration of speaker levels, speaker distances, and both speaker and subwoofer EQ, using a supplied microphone and built-in test tone generator.

Several speaker setup options are possible, from a traditional 5.1, 7.1, or 7.2 channel speaker configuration, to a Bi-amp setup where four channels can be devoted to compatible front speakers, and a 5.1.2 channel speaker Dolby Atmos setup option can be accommodated.

For video, both receivers incorporate HDMI 2.0a/HDCP 2.2 connections. HDMI capabilities include 3D, HDR, and 4K pass-through. Both receivers also include Blutooth (for direct streaming from compatible smartphones and tablets), Apple AirPLay, GoogleCast (via firmware update) , and FireConnect By BlackFire Research. FireConnect allows the receivers to stream audio directly to compatible Pioneer (and possibly Onkyo) wireless speakers placed in other locations throughout the home (specific products to be announced later in 2016).

Although both receivers share a lot in common, the VSX-LX301 adds some interesting perks, such as a higher power output 80 watts vs 100 watts), one additional HDMI input, analog-to-HDMI video conversion, Zone 2 operation, and custom control features accessible via 12 volt triggers and an RS232C port.

Read Full Review

If you are looking for a home theater receiver that is affordable, packs in a lot great features, and delivers good sound, check out the Onkyo TX-NR555.

First up, the NR555 is Onkyo's least expensive 7.2 channel receiver that provides both Dolby Atmos and DTS:X audio decoding, which provides an immersive surround experience. For non-Dolby Atmos and DTS:X encoded content, the NR555 also includes the Dolby Surround Upmixer and DTS Neural:X audio processing which enhances standard 2, 5.1, or 7.1 channel sources.

For video, the NR555 can pass thorough 3D and 4K video signals, as well as providing analog-to-HDMI video conversion, and 1080p to 4K video upscaling. The NR555 is also compatible with HDR encoded video content, which can be accessed via the Ultra HD Blu-ray Disc format, or via a 4K/HDR compatible media streamer (accessing 4K/HDR encoded content).

The TX-NR555 can also stream media content via the internet, Apple Airplay, DLNA, and Bluetooth. Both Ethernet and WiFi are provided for network and internet access.

Read Full Review

If you are looking for an affordable Home Theater Receiver that has surprisingly good audio performance, then consider the Sony STR-DN1070.

The STR-DN1070 provides traditional home theater audio and video features, such as up to a 7.2 channel configuration with Dolby TrueHD/DTS-HD decoding support, as well as, 6 4K, and HDR compatible HDMI inputs (along with 2 HDMI outputs), with support for analog to HDMI video conversion, as well as 1080p and 4K video upscaling

The STR-DN1070 also provides two-channel Hi-Res audio playback which can be accessed via HDMI, USB, or download to a compatible media server/storage device and then connected or streamed via a local network.

Files that can be accessed include ALAC, FLAC, AIFF, WAV, DSD.

Additional connections and features on the STR-DN1070 include a front mounted USB port for access to audio and video content from USB flash drives is also included, as well as the option of either built-in wired (ethernet) or wireless (WiFi) network connectivity, which provides access to DLNA functions and Internet Radio.

For additional content access, the STR-DN1070 also incorporates Airplay (for iOS devices), Google Cast Music Service (for iPhone and Android devices), and Bluetooth (including NFC). The Bluetooth feature is also bi-directional - You can stream content directly to the receiver from a compatible Bluetooth-enabled Source, or you can stream content from the receiver to a compatible Bluetooth headset.

To more easily manage your audio content, as well as control, Sony provides a free downloadable SongPal app for iOS or Android.

The Integra DRX-2 and DRX-3 are two Home Theater Receiver entries from Integra, which is the custom install product division of Onkyo.

The custom control features available on these receivers include: Bi-Directional RS232 control ports, Bi-Directional control via Ethernet, IR sensor input/output, RIHD (Remote control via HDMI), and three 12-volt triggers.

What all this means is that the DRX-2 and DRX-3 can be used to control video projection screens, lighting, and other components in a home theater setup, as well as being able to be integrated into a system that includes control via PCs and related devices.

In terms of audio and video, both receivers provide up to a 7.2 channel configuration, with 5.1.2 channel support for Dolby Atmos and DTS:X, as well as full pass-through capability for 3D, 4K, HDR, and Wide Color gamut video signals, and 1080p to 4K upscaling. Both receivers also feature wired and wireless network connectivity for access audio files from local devices as well as internet radio and several streaming music services.

Where the two receivers differ is that the DRX-2 has a stated power output of 80 wpc (2 channels driven, 8 ohms, 20-20kHZ, 0.08% THD), while the DRX-3 takes that up to 100 wpc using the same measuring standard. Also, the DRX-2 provides 6 HDMI inputs, while the DRX-2 adds two more inputs (includes one front-mounted input), for a total of 8. Also, for added connection flexibility, the DRX-3 provides a set of 7-channel analog preamp outputs.

Of course, there is more that these receivers offer - See Below:

Integra DRX-2 - Official Product Page

Integra DRX-3 - Official Product Page

Integra Home Theater Products are only available from distributors, and/or installers/dealers that specialize in home theater installation - Check out the Integra Home Theater Product Dealer Search Page:

Read Full Report

If you go through my home theater receiver product listings, you notice that they all seem to be big and bulky? Although that type of form factor is the commonly available, there are some home theater receivers that buck that trend. One example of a more compact, slim-design home theater receiver is the Marantz NR1607.

The NR1607 is only 4.1-inches high - not counting the Bluetooth/WiFi antennas, which are movable, 14.8-inches deep, and 17.3-inches wide). However, despite its space-saving design, the NR1607 still offers up a lot of practical features that help to provide good performance and connect access flexibility.

The NR1607 provides up to a 7.2 configuration with a stated 50 wpc power output. Although that is not as much power output as its "big brothers", for a smaller (or even some medium size) room that is more than enough.

Audio decoding/processing of most Dolby and DTS surround sound formats is provided, including Dolby Atmos (5.1.2 channel configuration) and DTS:X

The NR1607 also includes Audyssey MultEQ automatic speaker setup and room correction system, as well as an onscreen "Setup Assistant" menu interface guides you the rest of what you might need to get up and running.

There are 8 HDMI inputs (6 rear/1 front), and one HDMI output, which are 3D, 4K, and HDR and Wide Color Gamut compatible. The NR1607 includes analog to HDMI video conversion and both 1080p and 4K upscaling.

The NR-1607 also provides access to audio files stored on a network-connected PC or Media Server, and as well as access to several online content services, such as Spotify, Pandora, and Sirius/XM.

Additional streaming capabilities include Bluetooth and Apple AirPlay.

The NR1607 even includes Zone 2 operation capability.

You can control the NR1607 using the provided remote, or download the free Marantz remote control app for Android or iOS devices.

Read the Full Review

To start, the Onkyo TX-RZ900 THX Select2 Plus certified,

Core audio features include built-in 7.2 channel configuration, with Dolby Atmos and DTS:X audio decoding capability (DTS:X is added added via free firmware update).

In terms of connectivity, the TX-RZ900 supports both HDMI 2.o specification, which provides HDR High Dynamic Range video pass-through and HDCP 2.2 copy-protection. HDCP 2.2 provides secure access for 4K streaming and other applicable content passing through 5 of each receiver's 8 HDMI inputs).

In addition, two parallel HDMI outputs are provided. However, one important thing to note is that although the TX-RZ900 provides 1080p, 4K, and 3D pass-through, as well as analog-to-HDMI video conversion, it does not support video upscaling capability.

The TX-RZ900 also provides network connectivity (via Ethernet or WiFi), and both local and internet streaming options via Bluetooth, AirPlay, and internet access from services, such as Aupeo!, Pandora, Spotify, and more.

Also, the RZ900 also provides multi-zone functionality, such as powered and line outputs for a Zone 2 configuration, as well as preamp line output for a Zone 3 option (the preamp output options required external amplifiers).


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A Spot of Bother
Jonathan Cape, 2006 - Aged men - 390 pages
George Hall doesn't understand the modern obsession with talking about everything. 'The secret of contentment, George felt, lay in ignoring many things completely.' Some things in life, however, cannot be ignored.
At fifty-seven, George is settling down to a comfortable retirement, building a shed in his garden, reading historical novels, listening to a bit of light jazz. Then Katie, his tempestuous daughter, announces that she is getting remarried, to Ray. Her family is not pleased - as her brother Jamie observes, Ray has 'strangler's hands'. Katie can't decide if she loves Ray, or loves the wonderful way he has with her son Jacob, and her mother Jean is a bit put out by all the planning and arguing the wedding has occasioned, which get in the way of her quite fulfilling late-life affair with one of her husband's former colleagues. And the tidy and pleasant life Jamie has created crumbles when he fails to invite his lover, Tony, to the dreaded nuptials.
Unnoticed in the uproar, George discovers a sinister lesion on his hip, and quietly begins to lose his mind.
The way these damaged people fall apart - and come together - as a family is the true subject of Mark Haddon's disturbing yet very funny portrait of a dignified man trying to go insane politely.
What people are saying - Write a review
LibraryThing ReviewUser Review - dbsovereign - LibraryThing
A small British family lives through crisis after synchronous crisis in this droll, very dark comedy. Each member of the family is struggling with their own modern-day version of anguished malaise ... Read full review
LibraryThing ReviewUser Review - lucybrown - LibraryThing
Since I am myself prone to panics, about a quarter of the way through this book, I wondered if I was mad to be reading it. Besides, some of the characters were infantile and spoiled. But I kept with ... Read full review