text:
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
Travelers also recommend:
TripAdvisor Reviews Bulevard Sibiu
Travel Blogs from Sibiu
Home Alone - in Romania
... I was tired enough not to fret about every puff during the night.
I have found this part of the world very picturesque. Some of the villages are obviously battling economically and the resident population is definitely "ageing" but as one passes through it is really pretty. The villages are mainly along the roads or at intersections. The houses are painted in bright colours of the individual's choice. There may be ...
... the traffic volume was quite high with trams, bendy buses, buses, trolley buses, cars, horse carts, bicycles and pedestrians sharing the lane. Once past this bit the traffic suddenly came to a standstill. There was a group of horses (6) milling about on the road and pavement. They were frisky being out of their traces and they had no reins on them. We assumed they had escaped from a yard somewhere and went for an unsupervised canter. Fortunately ...
Dracula's Castle and a Rally
... and there were quite a few cars parked on the side of the road. We knew when the double zero car passed us that there was a rally around here somewhere! Just a few kilometres further up the road it was closed. We managed to park Tilly nearby and Neville went for a look. It was the Sibiu Rally Challenge. The cars did a run up the road one way and then another run back down. I stayed ...
... later, walked to the train station to find an ATM to take out Romanian leu, bought a few snacks to break up our big bills, walked back to the bus station, and got on another minibus to Sibiu.
One of the couples from minibus number one was also going to Sibiu and turned out to have reservations in our hostel, so we split a cab upon arriving in the city. By the time we settled into the hostel, the sun had started to ...
A day as any other
... in a bank and a PR company) and had some day decided to quit and try to live in the country side. They seemed to manage!
After a farewell, we continued our trip, thought about changing the train track (that wasn't in use any longer) into a bicycle path, passed some more fortified churches (some open to the public, some closed) and an orthodox monastery, to arrive at Hosman, where we knew there should be an old mill, where German bread should ...


text:
I will animate your logo professionally
About This Gig
I will create you a Logo Animation Intro video for your:
- Your Band
- Company
- Youtube Channel
- Your Business
- Website and more!
Here's what you'll get for $5:
You will get the video in 1280X720p HD Quality and Mp4 Format
Background is changeable
Full HD 1920x1080p quality
remove the background If your logo does not have a transparent background
How to Order:
send me your Logo
I'll also add any Tag Line, Slogan or Web Address you would like
You will have to send me a high resolution LOGO, atleast 600 x 600 size in JPG, PNG or GIF format.
Order Now for only $5!
Order Details
1 day delivery

subset: commoncrawl


text:
hp keyboard on screen caps lock
Related searches
Hp Keyboard On Screen Caps Lockat Software Informer
This application provides Caps Lock status indications.
Wireless Keyboard Caps Lock Indicator provides Caps Lock status
5 user rating
1 Filebird.com 10
Disable Caps Lock or Change Caps Lock to Underscore or Other Key.
10 George Jopling 558 Freeware
A simple free tool to keep you informed about the status of your Caps Lock key.
1 Alexander G. Styopkin
Caps Lock will automatically turn on after computer reload.
More Hp Keyboard On Screen Caps Lock
Hp Keyboard On Screen Caps Lock in introduction
1 KARPOLAN 145 Shareware
It shows the state of the Caps Lock key on the desktop and in the system tray.
4 Daanav 101 Freeware
It is a program that you can use to lock your keyboard and mouse.
9 KARPOLAN 2,373 Freeware
View on-screen status of Num, Caps, and Scroll lock keys.
7 Logitech 3,852 Freeware
Easily view the status of your cordless keyboard with this gadget.
Firma 10 Freeware
Tool to control Caps Lock/Num functionality and to facilitate word processing.
DKpcCODE, LLC 226 Freeware
Display's the Caps Lock, Insert and Num Lock key's status.
Additional titles, containing hp keyboard on screen caps lock
Fadsoft.net 15
Control Numlock, Caps Lock, and Scroll Lock indicator lights on the keyboard.
1 Binary Fortress Software 1,056 Shareware
Keyboard keys like Caps Lock, Num Lock, etc. right in your system tray.
Rob Crombie 18 Freeware
It averts Caps Lock-related problems by displaying a "CAPS LOCK ON" message.
1 Roi Dayan 80 Open source
It is an indicator for the Num Lock, Caps Lock, Scroll Lock and Insert keys.
Tordex 85 Freeware
Key State plugin shows the state of CAPS LOCK, NUM LOCK and SCROLL LOCK keys.
AlomWare 105 Freeware
It shows the LED status of the Num Lock, Caps Lock, and Scroll Lock keys.
EOF Productions Shareware
SnatchIt! Video Screen Capture software takes screen caps of MPEG,AVI,WMV,DivX files to create high-....
Tomas Kubec 1 Shareware
With this program thINGS lIKE tHIS will not ever happen to you. AntiCapsLock can disable CAPS LOCK k....
Easy HR Pty Ltd 2 Freeware
Easy HR Caps Lock sits quietly in the system tray.
Pavel Chuchuva 1 Freeware
Inserts a 1-second delay on the effect produced by the "Caps Lock" key.
SIL-Congo 1
Caps Lock Viewer
2007-03-15 Shai Coleman
Articles of interest› All articles


text:
Looking For The Best Way to Get XFINITY in La Conner, WA? CableTV.com Has What You Want
Because you can get XFINITY TV from Comcast in La Conner, WA, you can choose from multiple affordable packages to ensure you get the best TV programming for your home. If you're looking for digital cable channels, DVR packages, and On Demand options, XFINITY TV is the perfect choice for you.
Most Americans enjoy 35 hours of TV each week, and XFINITY TV provides La Conner, WA with enough top programming to fill that time. If you are a sports fan and need the local La Conner channels, you'll get them with cable TV from XFINITY. If you prefer movies and TV shows, you'll love the current and classic options included in XFINITY TV specials.


text:
Professor David Roberts
Dean of Faculty, National Teaching Fellow
School of English
- Email:
- email@example.com
David holds degrees from the Universities of Bristol and Oxford, completing his DPhil in 1987 under the supervision of the great Shakespeare scholar Emrys Jones. He worked at both universities before emigrating to Japan, where he taught at the Universities of Kyoto and Osaka.
He served as Head of English at Birmingham City University for ten years before becoming Dean of the Arts, Design and Media faculty. He gained a National Teaching Fellowship in 2013 and as a Fellow of the English Association, David welcomes all opportunities to teach and undertake external examining.
He has been published five times with Oxford University Press and twice with Cambridge, as well as textbooks for Taylor and Francis. His work has appeared in leading journals including Shakespeare Quarterly, New Theatre Quarterly, The Review of English Studies, and The Times Literary Supplement. Recent articles include a study of ethics and theatrical biography, and a philosophical critique of work on games and teaching in the humanities.
BA (Hons) - University of Bristol
DPhil - University of Oxford
English Drama, 1600-1700, theatre criticism, and English prose, 1660-1770.
Games for English Literature, Libri 2016.
'Writing the Ethical Life: Theatrical Biography and the Case of Thom as Betterton', in Claire Cochrane and Jo Robinson, eds.,Theatre History and Historiography: Ethics, Evidence and Truth (Palgrave), pp.33-47. Invited contribution.
'Shakespeare and the Jewellers', accepted for publication by Cambridge Quarterly with proofs due in March 2016.
'Chocolate Covered Broccoli? Games and the Teaching of Literature',Changing English, vol 22 no 2 (May 2015), pp.222-236. Co-authored with Izabela Hopkins.
'Theatre Criticism'and 'Jeremy Collier' in The Encyclopaedia of British Literature 1660-1789,ed. Gary Day and Jack Lynch (Wiley-Blackwell); two essays of 3,000 words each incorporating original research. Invited contributions.
The Life of Harris the Actor (Gold World Publishing, 2015)
Restoration Plays and Players: An Introduction (Cambridge University Press, 2014)
Thomas Betterton: The Greatest Actor of the Restoration Stage (Cambridge University Press, 2010)
Ed., Daniel Defoe, A Journal of the Plague Year (Oxford World's Classics, 2010)
'Class and the Seventeenth-Century Actor,' Studies in Theatre and Performance (2010)
'"I think no ill one". A Letter from Thomas Betterton sheds new light on the Chandos Portrait', The Times Literary Supplement, 14 August 2009
'"Almost Impossible in Praise": Dedicatory Criticism in English Dramatic Texts, 1660-1700', 1650-1850: Critical Voices Special Issue (October 2008)
'Thomas Betterton, Bookseller's Apprentice', The Review of English Studies (November 2007)
'Caesar's Gift: playing the park in the Seventeenth Century', ELH vol 71 (also given as conference paper at 'Literary London', Goldsmith's College London, 2002)
'Theatre Criticism and the Law', New Theatre Quarterly vol XIX part 3, 2003
'Sir Fopling in the Mall', Notes and Queries vol 50 n.s. no.3, 2003
'Shakespeare, Theater Criticism and the Acting Tradition', Shakespeare Quarterly vol 53 no.3, 2002
'Two Shakespearian Allusions and the Date of Marvell's "A Nymph Complaining for the Death of her Faun"', Notes and Queries vol 49 n.s. no.3, 2002
'Henry VIII and The True Chronicle History of King Leir', Notes and Queries vol 48 n.s. no.3, 2001
'Ravishing Strides: signs of the peripatetic on the seventeenth-century stage', New Theatre Quarterly vol XVII part 1, 2001
2001-2010 Numerous reviews for Notes and Queries, The Scriblerian, Shakespeare Quarterly; most recently of James Bulman, Shakespeare Cross-Dressed, for Shakespeare Quarterly, and the Wesleyan edition of Fielding's A Journal of a Voyage to Lisbon for Notes and Queries.
Currently working on Anglo-French Drama, 1660-1700; the life of William Congreve; an edition of the sale catalogue of Thomas Betterton's books and pictures, Pinacotheca Bettertonaeana; and a commissioned essay for Metzler Verlag on performances of Hamlet, 1600-1709.
Media Profile
Programme essays for The Royal Opera House, most recently for Hansel and Gretel (December 2008), on the history of fairytales and Handel's Tamerlano (March 2010, on Tamburlaine from Marlowe to Rowe). Guest contributor to Jude Kelly's Radio 4 programme on Restoration actresses, Summer 2010; interviews on BBC Hereford and Worcester, BBC Radio WM and Saga FM, Birmingham. Extensive correspondence/features in Times Higher Education; recent feature in the English Subject Centre publication, Wordplay, called 'Realising (English in) the University in the Twenty-First Century.' Pre-performance lecture on Stoppard and Sheridan for the Chichester Festival Theatre, August 2010.
Author/editor of four volumes for Oxford University Press including a 1989 monograph study of Restoration Audiences, The Ladies, and of two textbooks for Kogan Page/Taylor and Francis. David would welcome proposals for projects on Renaissance and Restoration Drama or on theatre criticism.
Media Work
Since 2008 David has written programme essays for the Royal Opera House Covent Garden, most recently for the 2016 production of Chabrier's L'Etoile. He has recently written a piece for the Bristol Old Vic to celebrate their opening night in May 1766.
David Roberts is one of the University's dedicated team of trained media champions, and can comment on a range of subjects including:
- Theatre
- The Arts
- Literature
- Opera
To arrange a media interview, please contact Birmingham City University Press Office on 0121 331 6738, 07967 271532,
email email@example.com or via Twitter @BCUPressOffice


text:
Microsoft Is Pulling the Sunrise Calendar App
Sunrise, sunset. After porting much of its functionality to Outlook mobile, Microsoft is yanking the popular calendar app from app stores.This summer, Sunrise users face a choice: switch to Outlook or look elsewhere for their mobile scheduling needs. The popular calendar app for iOS and Android is shutting down on Wednesday, August 31st. Microsoft acquired Sunrise Atelier, the app's developer, last year in a deal reportedly worth $100 million. The Sunrise team explained in a May 11 blog post that due to their involvement in developing the Outlook mobile apps, which inherited many of Sunrise's capabilities, they are no longer able to support the app. "No new features. No bug fixes. For us, that's the definition of a lousy app and it's not a user experience we want to leave you with," they wrote. Over the next few days, Microsoft will be yanking the Sunrise app from the Apple App Store and Google Play. "On August 31st, we'll officially shut down the app and it will stop working all together," they added.
Sunrise is bidding farewell on a high note and it's understandable that Microsoft will want to pull the app before its quality suffers. The app garnered a 4.5-star average rating on Apple's App Store and a 4-star rating at Google Play.
Loading Comments...


text:
Smoking a cigar is good way to demonstrate refined taste, rogue disposition, and staunch opposition to smoking salmon. Stay distinctive with today's Groupon: for $25, you get $50 worth of cigars and accessories at the Cigar Masters's Back Bay location.
Voted Best Cigar Shop in the 2010 Boston A-List contest, Cigar Masters houses a fragrant collection of fine cigars and smoking accessories in a sophisticated setting. The shop maintains an aromatic armory of over 50 brands of chic cigars, from time-tested classics like Romeo y Julieta ($10), to specialty smokecicles such as La Flor Dominicana ($13). Refined unwinders can send each other sophisticated smoke signals with the smoldering bouquet of Liga Privadas ($16 each) or replace their signature Slim Jim with a more dignified Don Pepin Garcia ($10). The knowledgeable staff receives ongoing education, keeping them keen on the latest lighters, cigar cases, and stylish smoking bibs. A luxurious, urbane lounge creates an ideal haven for aficionados who wish to bask in the glow of varnished wood and leather seats amidst an aura of refined conversation and stuffed trophy scotches. The lounge offers a full selection of libations and requires proper evening attire after seven. Cigar Masters supports a variety of local charities, including the Greater Boston Convention and Visitors Bureau and the Back Bay Association.
Customer Reviews
745 Boylston St.
Boston, Massachusetts 02116Get Directions


text:
Shop this video: preserve skincare pads in 60 seconds
Admit it...we've all gone to sleep without removing our makeup. Join Mikaela South as she shares her trick on how to clean, tone and hydrate your skin from bed. No more excuses. It only takes a minute!
The Preserve Skincare Cleansing Pads are a one-step process ending with cleansed, toned, slightly exfoliated and hydrated skin. Just wipe and go. Amazing for the gym bag, the low maintenance person, the busy mom, or to leave at the boyfriend's house or to use every day at your own sink because it's just that good.
Shop the video below to see the incredible power of these cleansing pads.


text:
ARM Project Home | Info for Volunteers | Results
Next ARM sampling date is Sunday April 2, 2017!
If you are interested in becoming a volunteer sampler, or if you have any questions about ARM, please contact the ARM statewide coordinator Travis Drury at tdrury[at]umass[dot]edu or by phone at (413) 545-5979.
Site Directions
ARM Site List
You can view the list above in your browser. It includes coordinates and map links for every site.
2017 ARM Site Map
Check out the map below to see which sites (indicated by the red symbols) still need volunteers for 2017. If you are interested in sampling any of these sites, please contact the ARM statewide coordinator Travis Drury at tdrury[at]umass[dot]edu or by phone at (413) 545-5979.
Site maps are also available in PDF format by county:
- Berkshire County
- Bristol County
- Essex County
- Franklin County
- Hampden County
- Hampshire County
- Middlesex County
- Norfolk County
- Plymouth County
- Worcester North County
- Worcester South County
Sampling Directions
- If sampling by a bridge, try to collect sample upstream of the bridge.
- If you can do so safely, wade into stream, walking upstream. Take sample upstream of your body. For lakes, sample at dam or shore.
- Uncap bottle, fill it partly, cover with cap, shake to rinse inside bottle and cap, and empty behind you.
- Repeat twice (rinse 3 times)
- Then completely immerse bottle in water, let it fill completely, and cap under water.
- Put in cooler with ice or frozen ice pack.
- Fill out field data sheet with your name, date and time of sampling, and samples taken.
- Deliver to lab and sign bottom of field data sheet at that time.
Downloadable Forms and Letters
Collector Data Sheet/Chain of Custody Sheet
2017 Volunteer Letter for Landowners
Analysis Method for pH and alkalinity - Care and maintenance of electrodes
Barnstable County
Contact: Alyssa Reischauer
Phone Number: (508) 487-3262
Cape Cod National Sea Shore
99 Marconi Site Rd.
South Wellfleet, MA
Bristol County
Contact: Robert Caron
Phone Number: (508) 241-1576
1435 Main Road
Westport, MA
Drop-off times: after 8AM Sunday April 3, 2016. Call if other arrangements need to be made.
Essex County
Contact: Joseph Ciccotelli or Phil McCarthy
Phone Number: (978) 356-6639
Ipswich Water Treatment Plant
274 High St
Ipswich, MA 01938
Drop-off times: after 7AM Monday April 4, 2016
Franklin County
Contact: Cathy Wilkins
Phone Number: (413) 337-5717
7 Underwood Hill Rd Heath.
Drop-off times: Sunday April 3, 2016. Cooler will be left on porch. Alternatively, samples may be left at Françoise's house in Greenfield: 63 Washington St, Greenfield, MA
Hampshire/Franklin Counties
Contact: Travis Drury
Phone Number: (413) 545-5979
5 Goessman Hall
Amherst, MA 01003
Directions from route 63
Map of campus
Drop off Times: 8am - 5pm Sunday April 3, 2016. There will be a cooler outside of the lab.
Southern Hampshire and part of Worcester County
Contact: Mark Putnam
Phone Number: (413) 323-6921 ext. 406
MWRA Quabbin Lab
485 Ware Road
Belchertown, MA 01007
Route 9 to 485 Ware Road. Brick building. Go to front door. Lab is upstairs.
Drop off Times: By 1pm Sunday April 3, 2016
Hampden/Berkshire Counties
Contact: Dr. Dave Christensen
Phone Number: (413) 572-5373
Westfield State University
577 Western Ave
Wilson Hall Room 216
Westfield, MA 01086
Map of campus
Drop off times: 10am - 2pm Sunday April 3, 2016
Middlesex County
Contact: Carmen DeFillippo
Phone Number: (978) 433-9859
47 Nashua Rd.
PO Box 319
Pepperell, MA
In Pepperell, follow Rte 111 North after split from Rte 122 for about 1 1/4 mile or less. Sign for WWTP on right. Follow road to end, cross at four way stop and enter driveway. Lab is in building straight ahead. Drive to rear of the building.
Drop off Times: 7:30 - 10:30am Sunday, April 3, 2016
Norfolk County
Contact: Laurissa Gulich, UMass Boston
Phone Number: (248) 977-7079
100 Morrissey Blvd
UMass Boston
Boston, MA 02125
Drop off Times: Sunday, April 3, 2016. Call Laurissa to coordinate drop-off time and place. Preferably morning.
Plymouth County
Contact: Bob Bentley and Jim Hoberg
Phone Number: Bentley: (508) 946-2225 Hoberg: (508) 295-2550
Analytical Balance Lab
Plymouth, MA
Worcester North
Contact: David Bennett
Phone Number: (978) 827-7065 (978-827-7063 home)
Cushing Academy
39 School St
Joseph R. Curry Academic Center, Room 104
Ashburnham, MA 01430
Please deliver your samples to: Room 104, Joseph Curry Academic Center, which is the first building on the left on Academy Street.
Drop off Times: 12-4pm (if earlier, there will be a tub outside the lab door) Sunday April 3, 2016
Worcester South
Contact: Debra LaVergne
Phone Number: (508) 755-1286 ext.14
Upper Blackstone Water Pollution Abatement District
50 Route 20
Millbury, MA 01527
If using a GPS device, enter the address as 7 Nippnapp Trail, Millbury, MA. From Route 20, turn onto Nippnapp Trail and go through the gates. Take a right after the gates and follow sign to the administration building.
Drop-off times: 7am-noon preferred on Sunday, April 3, 2016. Contact the lab prior to the sampling date if other times need to be arranged.
Lake and Stream Sensitivity Explained
How aquatic environments respond to acid deposition depends on their sensitivity to acids and the quantity of acids received. Most environments are naturally buffered against acid input by neutralizing materials such as limestone. If sufficient buffering capacity exists in an environment, excessive acid input does not change the pH of the water, although it will progressively deplete its acid neutralizing capacity (ANC). The soils, bedrock, and vegetation of watersheds largely determine the capacity of aquatic resources to accommodate acid deposition, but other factors play an important role. Acid neutralizing capacity can have its full effect only when the incoming precipitation has sufficient contact time with the neutralizing material. Areas with steep slopes, shallow soils or frozen ground tend to minimize contact time, resulting in incomplete neutralization of water entering lakes and streams. Additional neutralization is provided by the biota. For example, algae generate buffering materials during photosynthesis, and microbes living in bottom sediments reduce sulfur compounds to inert forms.ANC and pH interact in an unusual way: as acid is added to a buffered system, pH changes little until the ANC approaches zero. Then, small additions of acid cause large changes in pH. Finally, pH drops precipitously and permanently to levels that few aquatic organisms can tolerate.
With lower pH, levels of toxic metals leached from the watershed increase, aquatic growth is reduced, and sensitive species ranging from fish to algae disappear. If this occurs in a drinking water supply, metals will dissolve from distribution pipes resulting in high levels of iron, copper, lead and other metals.
|Sensitivity Categories
|Acid Neutralizing Capacity (mg/l)
|≤0 and pH≤5.0
|0 - 2 or <0 and pH≥5.0
|2 - 5
|Highly Sensitive
|5 - 10
|10 - 20
|Not Sensitive


text:
I found this very short clip on YouTube from 1995
. It has some of the cast members from LA, SFO and the original NY. Over the next few days if you find any great clips, e-mail them to me and I will post them and give them a permanent link so we can remember the best parts of the best shows.


text:
Thailand villa rentals confirm that there are still some idyllic corners of paradise left on this earth. With the same level of luxury perfected by more established beach destinations in a place so delightfully pristine, holidays to Thailand can be an extremely restful and rejuvenating experience.
From outdoor adventures to luxury spa experiences, Thailand appeals to a wide variety of travelers. Many of the best Thailand vacation rentals are located on Koh Samui, a sandy island famous for its towering coconut palms, or Phuket, Asia's most popular beach destination.
So, you have Koh Samui on your radar. You've seen the photos, you've heard the rave reviews, and you're well aware that it ha...
Whether it's time away for Christmas with the family or a New Year's beach blow-out, 'tis the season to travel and be merry! ...
In the morning, it's where we like to read the newspaper. In the afternoon, we happily congregate here for lunch. And when ev...
4 BR, Thailand, Phuket, Kamala
7 BR, Thailand, Koh Samui, Bang Por
4 BR, Thailand, Koh Samui, Taling Ngam
6 BR, Thailand, Phuket, Kamala
5 BR, Thailand, Phuket, Kamala
6 BR, Thailand, Koh Samui, Bophut
4 BR, Thailand, Koh Samui, Plai Laem
7 BR, Thailand, Phuket, Bang Tao
3 BR, Thailand, Koh Samui, Ban Laem Noi
4 BR, Thailand, Koh Samui, Bang Rak
Are you sure you want to log out?
Get Inspired with trip ideas & villa collections!
Learn more


text:
The OmniGlobe® is currently available with 32 inch, 48 inch or 60 inch diameter spheres. With our proprietary Enhanced Contrast Screen treatment, all show very well under normal ambient light conditions, and brilliantly under typical museum lighting conditions.
Each system comes with all the hardware and software necessary to be fully functional once installed and comes pre-loaded with the Content to be run. Systems can also come with an interactive kiosk control system configured for the level of interactivity desired. ARC understands that each clients requirements are unique and we will recommend the most appropriate configuration for each project.
- Select the button below to access a System Specifications sheet providing details on our standard OnmiGlobe® configurations;.
- Select the button below to access a list of all possible configurations for the OnmiGlobe®.


text:
HAPP course information
HAPP has revised the course requirements in response to the changing needs of the field. For those students that have already been in the program, you may consult your advisor to confirm which program would be best for you. For new majors, please use the link below to plan your academic schedules.
New program requirements: HAPP- checklist (starting 1/1/17)
Prior to January 1, 2017 program requirements: ADVISING-HAPP course checklist for majors prior to January 1, 2017
- Refer to the Frequently Asked Question's link for additional program information.


text:
Low E2F1 transcript levels are a strong determinant of favorable breast cancer outcome
DOI: 10.1186/bcr1681
© Vuaroqueaux et al.: licensee BioMed Central Ltd. 2007
Received: 1 March 2007
Accepted: 29 May 2007
Published: 29 May 2007
We investigated whether mRNA levels of E2F1, a key transcription factor involved in proliferation, differentiation and apoptosis, could be used as a surrogate marker for the determination of breast cancer outcome.
E2F1 and other proliferation markers were measured by quantitative RT-PCR in 317 primary breast cancer patients from the Stiftung Tumorbank Basel. Correlations to one another as well as to the estrogen receptor and ERBB2 status and clinical outcome were investigated. Results were validated and further compared with expression-based prognostic profiles using The Netherlands Cancer Institute microarray data set reported by Fan and colleagues.
E2F1 mRNA expression levels correlated strongly with the expression of other proliferation markers, and low values were mainly found in estrogen receptor-positive and ERBB2-negative phenotypes. Patients with low E2F1-expressing tumors were associated with favorable outcome (hazard ratio = 4.3 (95% confidence interval = 1.8–9.9), P = 0.001). These results were consistent in univariate and multivariate Cox analyses, and were successfully validated in The Netherlands Cancer Institute data set. Furthermore, E2F1 expression levels correlated well with the 70-gene signature displaying the ability of selecting a common subset of patients at good prognosis. Breast cancer patients' outcome was comparably predictable by E2F1 levels, by the 70-gene signature, by the intrinsic subtype gene classification, by the wound response signature and by the recurrence score.
Assessment of E2F1 at the mRNA level in primary breast cancer is a strong determinant of breast cancer patient outcome. E2F1 expression identified patients at low risk of metastasis irrespective of the estrogen receptor and ERBB2 status, and demonstrated similar prognostic performance to different gene expression-based predictors.
A variety of genes involved in breast cancer biology have been studied and proposed as prognostic or predictive biomarkers, but only a few of them, such as hormone receptors and ERBB2, are used today to classify breast cancer patients and to make treatment decisions in the clinical routine [1, 2]. The introduction of microarray analysis recently lead to a better characterization of breast cancer on a molecular level, underlining its biological heterogeneity and revealing that breast tumors can be grouped into different subtypes with distinct gene expression profiles and prognosis [3]. Some of these subtypes confirmed the relevance of established differences between phenotypes such as the estrogen receptor (ER) and ERBB2 status, but also identified novel breast cancer subtypes or prognostic signatures of potential clinical value [3–7]. Although little overlap was observed between these gene signatures at the level of individual genes, recent data indicate that the underlying biological processes and pathways might be common [8–10].
In terms of tumor biology, proliferation has been recognized as a distinct hallmark of cancer and as an important determinant of cancer outcome [11–13]. Increased tumor cell proliferation is accompanied by cell matrix remodeling and neo-angiogenesis, which together form the basis for an aggressive tumor phenotype [14, 15]. This observation was further underlined by recent reports showing that several genes involved in gene signatures discriminating clinically relevant breast cancer subtypes were related to proliferation [3, 4, 9, 16, 17].
In the context of breast cancer molecular screening, we recently investigated by quantitative RT-PCR the expression of 60 tumor-related genes in various subsets of breast cancers from the Stiftung Tumorbank Basel (STB) [18, 19]. This gene set also comprised several genes involved in proliferation such as thymidilate synthase (TYMS), thymidine kinase 1 (TK1), topoisomerase 2-alpha (TOP2A), survivin (BIRC5) and the transcription factor E2F1. Since these genes strongly correlated to one another and since the assessment of a single gene able to accurately predict breast cancer patients' outcome would represent major advantages for standard clinical use, we focused our efforts on the evaluation of E2F1 transcript levels as surrogate marker for proliferation. This transcription factor is well known for being involved in the cyclin/cyclin-dependent kinase/retinoblastoma pathway and for controlling the expression of more than 1,000 genes involved in cell proliferation, differentiation and apoptosis [20–23]. In a set of 317 primary breast cancers patients with known clinical outcome (STB data set), we evaluated E2F1 mRNA expression levels with respect to other proliferation markers, ER and ERBB2 status and clinical outcome. All results obtained in our collective were subsequently validated in The Netherlands Cancer Institute (NKI) microarray data set comprising 295 breast cancer patients. Moreover, the prognostic value of E2F1 was compared with the 70-gene prognostic signature, and with other gene expression-based predictors such as the intrinsic subtypes, the wound response signature and the recurrence score available as reported by Fan and colleagues using the same NKI data set [8].
Study populations
Patient and tumor characteristics
Stiftung Tumorbank Basel data set
The Netherlands Cancer Institute data set
Quantitative RT-PCR
Agilent Microarray
Mean/median (years)
≤ 40 years
20 (6%)
75 (25%)
41–55 years
110 (35%)
220 (75%)
≥ 56 years
187 (59%)
0 (0%)
pT stage
100 (32%)
155 (53%)
183 (58%)
140 (47%)
33 (10%)
pN status
161 (54%)
151 (51%)
136 (46%)
144 (49%)
Histological grade
1 (good)
28 (9%)
75 (25%)
2 (intermediate)
137 (46%)
101 (34%)
3 (poor)
133 (45%)
119 (41%)
Estrogen receptor statusa
231 (73%)
226 (77%)
86 (27%)
69 (23%)
ErbB2 status
70 (22%)
52 (18%)
247 (78%)
243 (82%)
Adjuvant therapy
60 (20%)
165 (56%)
135 (44%)
20 (7%)
72 (24%)
90 (30%)
38 (12%)
20 (7%)
245 (80%)
130 (44%)
Events (metastases)
57 (18%)
101 (34%)
Mean/median metastasis-free survival (years)
Quantitative real-time PCR analysis
Gene expression measurements by quantitative RT-PCR were performed as reported previously [24]. Total RNA was extracted using the RNAeasy Mini Kit (Qiagen, Hilden, Germany) and was quality-checked on a Bioanalyzer 2100 (Agilent Technologies, Palo Alto, CA, USA). High-quality RNA samples were reverse-transcribed and PCR was carried out in 40 cycles on a ABI Prism 7000 using 2× SYBR Green I Master Mix (Applied Biosystems, Forster City, CA, USA). Relative gene expression quantities (Δ[Ct] values) were obtained by normalization against ribosomal 18S RNA.
Statistical analysis
For the STB study the ER status was defined based on the mRNA level as reported previously [24], and for the NKI data set the status was defined as provided by the authors [5, 8]. The ERBB2 status was determined in both the STB and NKI data sets using mRNA expression levels for all study populations as previously described by Urban and colleagues [18].
The prognostic value of biomarkers was assessed by univariate and multivariate Cox analysis against metastasis-free survival (MFS), and in different patient subgroups according to the ER and ERBB2 status. The association of E2F1 with MFS in particular was assessed by univariate Cox analysis for various cutoff values (data not shown). For all subsequent analysis, the 30th percentile was used as the cutoff point for E2F1. Survival probabilities for MFS were calculated according to the Kaplan–Meier method, and group differences were assessed by the logrank test. Multivariate P values were based on Wald statistics. Statistical analysis was performed with 'R' statistical software version 2.0.1 using the 'survival' package [25].
E2F1 correlated with other proliferation markers and clinical outcome
Correlation among different proliferation markers in the Stiftung Tumorbank Basel data set and association with survival
Univariate Cox regressionb (P value)
Distinct E2F1 expression patterns according to ER and ERBB2 status determined the clinical outcome
Cox univariate survival analysis performed in subsets of patients according to their ER and ERBB2 status showed that E2F1 correlated with MFS in ER-positive and ERBB2-negative tumors, but not in ER-negative and ERBB2-positive tumors (data not shown). Combined Kaplan–Meier analysis using E2F1 and the ER or ERBB2 status revealed that patients whose tumors expressed low E2F1 levels, a situation found mainly in ER-positive and ERBB2-negative phenotypes, were associated with favorable outcome, whereas patients with tumors expressing high E2F1 levels revealed a poor outcome independent of the ER and ERBB2 status (Figure 1e-h).
E2F1 correlated well with the 70-gene signature
Concordance of E2F1 with the 70-gene signature in The Netherlands Cancer Institute data set
Proliferation status (E2F1)
NKI 70-gene signature prognosis
E2F1 ≤ p30
4/69 (5.7%)
6/21 (28.6%)
10/90 (11.1%)
E2F1 > p30
12/46 (26.1%)
79/159 (49.6%)
91/205 (44.4%)
16/115 (13.9%)
85/180 (47.2%)
101/295 (34.2%)
E2F1 stratification showed similar prognostic value as the 70-gene and other gene-based predictors
E2F1 was a strong and independent survival factor in multivariate analysis
Univariate and multivariate Cox analyses in the Stiftung Tumorbank Basel data set (n = 317)
Univariate metastasis-free survival
Multivariate metastasis-free survival
Hazard ratio (95% confidence interval)
P value
Hazard ratio (95% confidence interval)
P value
E2F1 (>p30 versus ≤ p30)
4.27 (1.83–9.96)
2.95 (1.10–7.93)
Grade (3 versus 1 + 2)
2.03 (1.17–3.51)
1.56 (0.77–3.14)
Estrogen receptor status (positive versus negative)
0.64 (0.37–1.12)
1.21 (0.56–2.61)
ERBB2 status (positive versus negative)
1.69 (0.98–2.92)
1.41 (0.70–2.81)
pN (>3 nodes versus ≤ 3 nodes)
3.14 (1.76–5.61)
2.36 (1.14–4.88)
Size (>2 cm versus ≤ 2 cm)
1.95 (1.05–3.62)
1.19 (0.58–2.43)
Age (≤ 40 years versus >40 years)
0.30 (0.15–0.59)
0.59 (0.24–1.43)
2.65 (1.54–4.55)
1.27 (0.45–3.59)
Hormone therapy
0.50 (0.28–0.88)
0.76 (0.27–2.17)
70-gene signature (poor versus good prognosis)
Not available
Not available
Not available
Not available
Univariate and multivariate Cox analyses in The Netherlands Cancer Institute data set (n = 295)
Univariate metastasis-free survival
Multivariate metastasis-free survivala
Hazard ratio (95% confidence interval)
P value
With 70-gene signature
Without 70-gene signature
Hazard ratio (95% confidence interval)
P value
Hazard ratio (95% confidence interval)
P value
E2F1 (>p30 versus ≤ p30)
5.09 (2.65–9.78)
3.76 (1.90–7.45)
2.47 (1.20–5.10)
Grade (3 versus 1 + 2)
2.38 (1.60–3.52)
1.28 (0.82–2.00)
1.02 (0.65–1.60)
Estrogen receptor status (positive versus negative)
0.54 (0.36–0.83)
0.99 (0.61–1.59)
1.11 (0.70–1.78)
ERBB2 status (positive versus negative)
1.61 (1.01–2.57)
1.35 (0.82–2.21)
1.28 (0.78–2.09)
pN (>3 nodes versus ≤ 3 nodes)
2.20 (1.37–3.53)
2.69 (1.47–4.91)
Size (>2 cm versus ≤ 2 cm)
2.08 (1.39–3.10)
1.70 (1.12–2.58)
1.73 (1.14–2.62)
Age (≤ 40 years versus >40 years)
0.50 (0.33–0.75)
0.59 (0.38–0.89)
0.67 (0.43–1.02)
0.79 (0.52–1.19)
0.61 (0.38–1.00)
0.55 (0.33–0.91)
Hormone therapy
0.58 (0.28–1.19)
0.60 (0.28–1.27)
0.58 (0.27–1.23)
70-gene signature (poor versus good prognosis)
4.55 (2.67–7.77)
Not included
Not included
2.78 (1.49–5.21)
In the present study we demonstrated that the assessment of E2F1 mRNA as a surrogate proliferation marker is a strong determinant of breast cancer outcome, particularly suitable for identifying patients at very low risk of metastasis, comparable with gene expression-based signatures such as the 70-gene signature. The prognostic component of the ER and ERBB2 status as well as different gene signatures were found to be strongly related to tumor proliferation. In fact, a large subset of patients classified with very favorable outcome shared a common molecular tumor phenotype characterized by ER-positive and/or ERBB2-negative status and low proliferation (low levels of E2F1 as well as BIRC5,TYMS,TOP2A and TK1). Moreover, the results obtained in our data set analyzed by quantitative RT-PCR were successfully validated in an independent breast cancer data set using microarray technology.
Sotiriou and colleagues developed a gene expression grade index able to reclassify breast cancer patients with tumor histological grade 2 into groups with high risk of recurrence versus low risk [9]. The gene expression grade index was developed on the basis of the analysis of five breast cancer microarray data sets including more than 600 tumors, from which the authors extracted a list of 242 genes associated with tumor grade and predicting patient outcome. Most of these genes were related to proliferation and cell survival, such as E2F1 and MKI67, BIRC5, TOP2A and STK6, all being highly correlated and providing similar prognostic information. In our study, we demonstrated that the detection of a single gene is sufficient to select tumors at low proliferation. A single gene assessment requires high RNA quality from fresh (frozen) tissue, however, and might be insufficient in cases of more heterogeneous RNA quality (for example, RNA from paraffin-embedded tissues).
Breast cancer has been successfully classified using microarrays into clinically relevant subgroups based on variations in gene expression patterns. Sorlie and colleagues showed that ER-negative tumors grouped into basal-like and ERBB2 subtypes, both with poor prognosis [3]. In contrast, ER-positive breast cancers could be classified into luminal A and luminal B subtypes with significantly distinct prognosis: luminal A tumors displayed favorable outcome, whereas survival of patients with luminal B tumors was poor and comparable with those of the ER-negative ERBB2 and basal subtypes [3]. Our classification in the NKI data set revealed that 81% of the tumors expressing low E2F1 levels (below this study's cutoff point) corresponded with luminal A subtype as defined by Fan and colleagues [8], and subsequently had similar prognostic value (Figure 3b).
Van de Vijver and colleagues used a 70-gene prognostic signature to discriminate patients with good prognosis and poor prognosis [5], which according to our analysis strongly correlated with E2F1 expression levels. As shown in Figure 2, patients defined as of good prognosis by the 70-gene signature had tumors expressing low E2F1 levels and were mainly ER-positive. Despite all observed correlations, multivariate Cox analysis of the NKI data set showed that E2F1 levels and the 70-gene prognostic signature retained additive significance when both covariates were included (Table 5). This is probably due to the fact that both markers classified, in addition to the overlapping patients at very low risk, patients at similar but higher risk who would not have been selected by either classifier alone (Table 3). Furthermore, we found that almost all ERBB2-positive and ER-negative tumors expressed high levels of E2F1 and were classified as of poor prognosis according to the 70-gene signature – suggesting an explanation of why Espinosa and colleagues were unsuccessful in improving the accuracy of the 70-gene signature by incorporating additional genes such as ERBB2 [26].
Fan and colleagues [8] recently demonstrated that the different gene-expression-based predictors including the 70 gene-signature, the intrinsic subtypes, the wound signature and the recurrence score were highly concordant to evaluate breast cancer outcome. Our analysis revealed that low proliferation as quantified by low levels of E2F1 represented a common determinant of patients with good prognosis (Figures 2 and 3). It has to be noted that the prognostic value of E2F1 was independent of the nodal status. Indeed, 40% of the STB tumors and 50% of the NKI tumors with low E2F1 expression levels belonged to nodal-positive patients at very low risk of metastases, reconfirming the impact of proliferation recently reported in a study evaluating breast cancer patients with 10 and more positive lymph nodes [27, 28].
The STB and NKI data sets differed in adjuvant treatment modalities; in general, patients of the STB collective were older and consequently received more hormone therapy but less chemotherapy as compared with patients of the NKI collective. In this context, it has to be emphasized that treatment regiments were chosen independent of the E2F1 status (Additional file 1) and that E2F1 levels retained predictive survival significance in patients with and without different adjuvant treatments (Additional file 2). Multivariate analyses, however, revealed different treatment impacts in the two data sets (Tables 4 and 5). In the STB collective, chemotherapy was particularly significant in univariate Cox analysis but was nonsignificant in multivariate Cox models, suggesting that information about the higher risk cases receiving chemotherapy is already included in the combination of the other covariates. Since E2F1 is co-expressed or regulates genes such as TYMS, TK1 and TOP2A, which were mechanistically linked with response to 5-fluorouracil and anthracycline-based therapy [16, 29–32], however, our results with respect to specific chemotherapy response should be further investigated.
Since accurate monitoring of proliferation assessing the mRNA E2F1 levels together with the determination of the ER and ERBB2 status can be performed easily by quantitative RT-PCR even in small amounts of tissue such as core biopsies [19], we encourage the inclusion of such analyses in protocols of ongoing clinical and translational research investigations, including predictive studies with respect to specific chemotherapies.
estrogen receptor
metastasis-free survival
The Netherlands Cancer Institute
polymerase chain reaction
reverse transcriptase
Stiftung Tumorbank Basel.
VV and PU contributed equally to the work. This work was supported by the Stiftung Tumor Bank Basel, the Swiss National Foundation (Grant 3100-059819.99/1) and the NCCR Molecular Oncology of the Swiss National Science Foundation. OncoScore AG paid the costs for quantitative RT-PCR analysis. The authors are very grateful to Sabine Ehret for technical support and data management. They thank pathologists for providing tumor tissues, in particular Prof. H. Moch, Prof. M. Mihatsch and Prof. W. Wegmann. The authors are indebted to all clinicians for their collaboration in collecting clinical data, especially to Prof. D. Fink, PD Dr E. Wight and Dr K. Lüscher.
Authors' Affiliations
- Esteva FJ, Hortobagyi GN: Prognostic molecular markers in early breast cancer. Breast Cancer Res. 2004, 6: 109-118. 10.1186/bcr777.View ArticlePubMedPubMed CentralGoogle Scholar
- Goldhirsch A, Glick JH, Gelber RD, Coates AS, Thurlimann B, Senn HJ: Meeting highlights: International Expert Consensus on the Primary Therapy of Early Breast Cancer 2005. Ann Oncol. 2005, 16: 1569-83. 10.1093/annonc/mdi326.View ArticlePubMedGoogle Scholar
- Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001, 98: 10869-10874. 10.1073/pnas.191367098.View ArticlePubMedPubMed CentralGoogle Scholar
- van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, et al: Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002, 415: 530-536. 10.1038/415530a.View ArticlePubMedGoogle Scholar
- van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, et al: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med. 2002, 347: 1999-2009. 10.1056/NEJMoa021967.View ArticlePubMedGoogle Scholar
- Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, Talantov D, Timmermans M, Meijer-van Gelder ME, Yu J, et al: Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet. 2005, 365: 671-679.View ArticlePubMedGoogle Scholar
- Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO: Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol. 2004, 2: E7-10.1371/journal.pbio.0020007.View ArticlePubMedPubMed CentralGoogle Scholar
- Fan C, Oh DS, Wessels L, Weigelt B, Nuyten DS, Nobel AB, van't Veer LJ, Perou CM: Concordance among gene-expression-based predictors for breast cancer. N Engl J Med. 2006, 355: 560-569. 10.1056/NEJMoa052933.View ArticlePubMedGoogle Scholar
- Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, Smeds J, Nordgren H, Farmer P, Praz V, Haibe-Kains B, et al: Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst. 2006, 98: 262-272.View ArticlePubMedGoogle Scholar
- Brenton JD, Carey LA, Ahmed AA, Caldas C: Molecular classification and molecular forecasting of breast cancer: ready for clinical application?. J Clin Oncol. 2005, 23: 7350-7360. 10.1200/JCO.2005.03.3845.View ArticlePubMedGoogle Scholar
- Hanahan D, Weinberg RA: The hallmarks of cancer. Cell. 2000, 100: 57-70. 10.1016/S0092-8674(00)81683-9.View ArticlePubMedGoogle Scholar
- van Diest PJ, van der Wall E, Baak JP: Prognostic value of proliferation in invasive breast cancer: a review. J Clin Pathol. 2004, 57: 675-681. 10.1136/jcp.2003.010777.View ArticlePubMedPubMed CentralGoogle Scholar
- Desmedt C, Sotiriou C: Proliferation: the most prominent predictor of clinical outcome in breast cancer. Cell Cycle. 2006, 5: 2198-2202.View ArticlePubMedGoogle Scholar
- Ellis LM, Fidler IJ: Angiogenesis and metastasis. Eur J Cancer. 1996, 32A: 2451-2460. 10.1016/S0959-8049(96)00389-9.View ArticlePubMedGoogle Scholar
- Eppenberger U, Kueng W, Schlaeppi JM, Roesel JL, Benz C, Mueller H, Matter A, Zuber M, Luescher K, Litschgi M, et al: Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients. J Clin Oncol. 1998, 16: 3129-3136.PubMedGoogle Scholar
- Dai H, van't Veer L, Lamb J, He YD, Mao M, Fine BM, Bernards R, van de Vijver M, Deutsch P, Sachs A, et al: A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res. 2005, 65: 4059-4066. 10.1158/0008-5472.CAN-04-3953.View ArticlePubMedGoogle Scholar
- Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, et al: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004, 351: 2817-2826. 10.1056/NEJMoa041588.View ArticlePubMedGoogle Scholar
- Urban P, Vuaroqueaux V, Delorenzi M, Wirapati P, Labuhn M, Benz C, Wight E, Senn HJ, Eppenberger U, Eppenberger-Castori S: Increased expression of urokinase-type plasminogen activator (uPA) mRNA determines adverse prognosis in ErbB2-positive breast cencer patients. J Clin Oncol. 2006, 24: 4245-53. 10.1200/JCO.2005.05.1912.View ArticlePubMedGoogle Scholar
- Zanetti-Dallenbach R, Vuaroqueaux V, Wight E, Labuhn M, Singer G, Urban P, Eppenberger U, Holzgreve W, Eppenberger-Castori S: Comparison of gene expression profiles in core biopsies and corresponding surgical breast cancer samples. Breast Cancer Res. 2006, 8: R51-10.1186/bcr1542.View ArticlePubMedPubMed CentralGoogle Scholar
- Muller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD, Helin K: E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 2001, 15: 267-285. 10.1101/gad.864201.View ArticlePubMedPubMed CentralGoogle Scholar
- Bell LA, Ryan KM: Life and death decisions by E2F-1. Cell Death Differ. 2004, 11: 137-142. 10.1038/sj.cdd.4401324.View ArticlePubMedGoogle Scholar
- Zhang SY, Liu SC, Al-Saleem LF, Holloran D, Babb J, Guo X, Klein-Szanto AJ: E2F-1: a proliferative marker of breast neoplasia. Cancer Epidemiol Biomarkers Prev. 2000, 9: 395-401.PubMedGoogle Scholar
- Baldini E, Camerini A, Sgambato A, Prochilo T, Capodanno A, Pasqualetti F, Orlandini C, Resta L, Bevilacqua G, Collecchi P: Cyclin A and E2F1 overexpression correlate with reduced disease-free survival in node-negative breast cancer patients. Anticancer Res. 2006, 26: 4415-4421.PubMedGoogle Scholar
- Labuhn M, Vuaroqueaux V, Fina F, Schaller A, Nanni-Metellus I, Kung W, Eppenberger-Castori S, Martin PM, Eppenberger U: Simultaneous quantitative detection of relevant biomarkers in breast cancer by quantitative real-time PCR. Int J Biol Markers. 2006, 21: 30-39.PubMedGoogle Scholar
- 'R' Statistical Software. [http://www.r-project.org]
- Espinosa E, Vara JA, Redondo A, Sanchez JJ, Hardisson D, Zamora P, Pastrana FG, Cejas P, Martinez B, Suarez A, et al: Breast cancer prognosis determined by gene expression profiling: a quantitative reverse transcriptase polymerase chain reaction study. J Clin Oncol. 2005, 23: 7278-7285. 10.1200/JCO.2005.01.4746.View ArticlePubMedGoogle Scholar
- Cobleigh MA, Tabesh B, Bitterman P, Baker J, Cronin M, Liu ML, Borchik R, Mosquera JM, Walker MG, Shak S: Tumor gene expression and prognosis in breast cancer patients with 10 or more positive lymph nodes. Clin Cancer Res. 2005, 11: 8623-8631. 10.1158/1078-0432.CCR-05-0735.View ArticlePubMedGoogle Scholar
- Miyoshi Y, Ando A, Egawa C, Taguchi T, Tamaki Y, Tamaki H, Sugiyama H, Noguchi S: High expression of Wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients. Clin Cancer Res. 2002, 8: 1167-1171.PubMedGoogle Scholar
- Longley DB, Harkin DP, Johnston PG: 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003, 3: 330-338. 10.1038/nrc1074.View ArticlePubMedGoogle Scholar
- Di Leo A, Cardoso F, Durbecq V, Giuliani R, Mano M, Atalay G, Larsimont D, Sotiriou C, Biganzoli L, Piccart MJ: Predictive molecular markers in the adjuvant therapy of breast cancer: state of the art in the year 2002. Int J Clin Oncol. 2002, 7: 245-253. 10.1007/s101470200036.View ArticlePubMedGoogle Scholar
- Gianni L, Zambetti M, Clark K, Baker J, Cronin M, Wu J, Mariani G, Rodriguez J, Carcangiu M, Watson D, et al: Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer. J Clin Oncol. 2005, 23: 7265-7277. 10.1200/JCO.2005.02.0818.View ArticlePubMedGoogle Scholar
- Rosty C, Sheffer M, Tsafrir D, Stransky N, Tsafrir I, Peter M, de Cremoux P, de La Rochefordiere A, Salmon R, Dorval T, et al: Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma. Oncogene. 2005, 24: 7094-7104. 10.1038/sj.onc.1208854.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Endzone177 wrote on Kezaaargh's wall
"AC3 deserves a 10"
Kezaaargh Played much of it yet? Would be interested to know why you think so - I was really, really impressed initially, but the sheen wore off slightly as things progressed.4 years ago
gamer013335 it deserved at least a 9 dude and i played it4 years ago
Endzone177 Yes, Yes I have. I loved playing as Haytham and thought he was amazing. It was not slow in the beginning in my opinion. AC2 was amazing and that deserved a 9.5. Since this was so much better I believe it deserves a ten. Connor is awesome and he makes you feel more powerful than ever. I loved the story and was angry ho...expand4 years ago
mikeerik She talked about Desmond in the review. I think that the Desmond sections improved from other games but there should have given a plot for Lucy and Subject 16 even though they're gone Ubisoft should have done some sort of plot twist for those characters and they ditched on a storyline plot at the end of ACB where Juno says ...expand4 years ago


text:
A Diary from Dixie
By (author) Mary Boykin Chesnut
Volume editor Ben Ames Williams
Foreword by Edmund Wilson
Format: Paperback
Normal Price: $69.00
Your Price: $62.10 AUD, inc. GST
Shipping: $7.95 per order
You Save: $6.90! (10% off normal price)
Plus...earn $3.11 in Boomerang Bucks
Availability: Available to Backorder, No Due Date for Supply
Diary from Dixie by Mary Boykin Chesnut
Book DescriptionOne of the most important documents in southern history, this is a day-by-day diary of the Civil War years. It rings with authenticity while evoking the nostalgia, bitterness, and comedy of the Confederacy.
Buy Diary from Dixie book by Mary Boykin Chesnut from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780674202917
(210mm x 140mm x 40mm)
Pages: 608
Imprint: Harvard University Press
Publisher: Harvard University Press
Publish Date: 1-Jul-1980
Country of Publication: United States
Other Editions...
Books By Author Mary Boykin Chesnut
Mary Chesnut's Diary, Paperback (September 2011)
A personal narrative of the Civil War written between 1861 and 1865. It captures the urgency and nuance of the period in an epic with commentary on race, status, and power within a nation divided.
Private Mary Chesnut, Paperback (September 1985)View all books by Mary Boykin Chesnut
Pulitzer Prize-winning historian C. Vann Woodward and Chestnut's biographer Elisabeth Muhlenfeld present here the previously unpublished Civil War diaries of Mary Boykin Chestnut. Intimate and spontaneous, these surviving wartime diaries are preserved in their original form.
» Have you read this book? We'd like to know what you think about it - write a review about Diary from Dixie book by Mary Boykin Chesnut and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Facebook Page | Twitter | Google+ | Bulletin e-Newsletter | Blog | RSS
Become a Member | Book Lists | Recently Released | Coming Soon | Fast Delivery Books
Bestselling Books: Our Current Bestsellers | Australia's Hottest 1000 Books | Bestselling Fiction | Bestselling Crime Mysteries and Thrillers | Bestselling Non Fiction Books | Bestselling Sport Books | Bestselling Gardening and Handicrafts Books | Bestselling Biographies | Bestselling Food and Drink | Bestselling History | Bestselling Travel Books | Bestselling School Textbooks & Study Guides | Bestselling Children's General Non-Fiction | Bestselling Young Adult Fiction | Bestselling Children's Fiction | Bestselling Picture Books | Top 100 US Bestsellers
For: Schools | Organisations | Libraries | Publishers | Authors | Book Clubs | Bloggers | Affiliates
About Us | Contact Us | Help Desk | Security | Privacy | Terms of Use | Copyright
Phone: 1300 36 33 32 (9am-5pm Mon-Fri AEST) - International: +61 2 9960 7998 - Online Form
Address: Boomerang Books, 878 Military Road, Mosman Junction, NSW, 2088
© 2003-2017. All Rights Reserved. Eclipse Commerce Pty Ltd - ACN: 122 110 687 - ABN: 49 122 110 687
For every $20 you spend on books, you will receive $1 in Boomerang Bucks loyalty dollars. You can use your Boomerang Bucks as a credit towards a future purchase from Boomerang Books. Note that you must be a Member (free to sign up) and that conditions do apply.


text:
High Speed Internet Providers – Tennessee
Consumers throughout Tennessee (TN) are using the internet to look-up information, communicate with friends and family, shop for gifts, and map driving destinations (remember: check your bandwidth performance regularly with an Internet speed test). They do so working with different broadband internet technologies, like satellite, cable, DSL, and T1 or bonded T1 lines, all of which are available through a variety of high speed internet service providers (ISPs).
Satellite Internet
Those living in rural areas of Tennessee used to be constrained to dial-up methods of internet access. However, now they have a broadband access option: satellite internet from ISPs like HughesNet, StarBand, SkyWay USA, and WildBlue. Connections are delivered via a satellite dish and a modem, which connect to the user's computer. All that is needed is the required equipment and a clear view to the south, where the satellites are in orbit around the equator.
Cable Internet
With many homes and apartments now being wired for cable television access, lots of consumers also have cable internet access, which is provided through the existing cable network, with the connection terminating in a cable modem instead of a cable television box. Some of the cable ISPs serving the state include Adelphia, Cable One, Cebridge Communications, Comcast, and Time Warner Cable.
DSL Internet Access
Digital subscriber lines — the long way of saying DSL — provide broadband internet connectivity through the phone line. It is an always-on connection and the technology allows the same phone to be used for normal calls at the same time the user is online. DSL providers like Adelphia, BellSouth, Sprint, Verizon, and Yahoo! DSL all offer DSL service in Tennessee.
Bonded T1 and T1 Lines
A T1 or bonded T1 lines are perfect for businesses that need to have lots of people online, simultaneously. They offer a lot of bandwidth so transmission speeds — both upstream and downstream — are not slowed when multiple users are all using the internet. Covad, MegaPath, and Qwest all deliver T1 access.


text:
Driving holidays in Europe
Plan your self-drive motoring holiday
Hotels in Hittisau from Drive-Alive.
Hittisau hotel search and online booking.
Toggle navigation
Car hire
Tourist info
Self catering
Hotel search
To find a hotel use the quick search box or zoom on the map
Did you mean...
When would you like to stay? (optional)
Hotel star rating (optional)
1 -
2 -
3 -
4 -
5 -
1 -
2 -
3 -
4 -
5 -
Hotel facilities (optional)
Tick as many as you like then click 'Find Hotels', but remember that the more you tick the less your choice of accommodation
Air Conditioning
Babysitting/Child Services
Bicycles Available
Breakfast Avaiable
Breakfast in Room
Bridal Suite
Business Centre
Car Hire
Children's Playground
Currency Exchange
Family Rooms
Fitness Centre
Garden or Terrace
Gay Friendly
Golf Course within 3 km
Indoor Swimming Pool
No Smoking Property
No Smoking Rooms
Outdoor Swimming Pool
Parking Available
Parking Free
Pets Welcome
Rooms for Disabled Guests
Shuttle Service
Ski Equipment Hire
Ski Pass Available
Ski School
Ski Storage
Ski to Door
Tennis Court
Wellness Centre/Spa
Wi-Fi Available
Wi-Fi/Internet Free
Map View
List View
-> Hittisau
Please wait while we search for hotels...
To save your favourite places click the "+ Shortlist" button in the list view or when viewing individual properties
Sort by
Price (Low to high)
Price (High to low)
Hotel rating (High to low)
Hotel rating (Low to high)
Guest rating (High to low)
Guest rating (Low to high)
Results: 1 to 20 of 184
Hotel Gasthof Krone
Hittisau (0.0km from town centre)
The Krone is a traditional, family-run Bregenz Forest inn, centrally located at the main village square of Hittisau. Here you will find comfortable rooms with free Wifi, a small sauna, a fireplace lounge, a garden and a terrace with a view of the village. A ping pong table (in summer), 2 bicycles and a toboggan (in winter) are available. On the ground floor there is a small newspaper and tobacco shop and a hairdresser. Enjoy a wide range of reg
Hotel Gasthof Krone
Close [x]
Prices from only EUR 116
Gästehaus Gitti Dorner
Hittisau (0.2km from town centre)
Located 250 metres from the village centre of Hittisau, Gästehaus Gitti Dorner offers rooms with flat-screen TV and free private parking. The Balderschwang Ski Area is 12 km away, and a ski bus stop is 250 metres from the property. Each room features a balcony and comes with a desk and a private bathroom with shower and toilet. A ski storage room is provided on site, and at a surcharge, guests of the Gitti Dorner Gästehaus can use the sauna. A
Gästehaus Gitti Dorner
Close [x]
Ferienwohnungen Familie Eberle
Hittisau (0.2km from town centre)
Ferienwohnungen Familie Eberle is situated 100 metres from the centre of Hittisau, with cross-country skiing trails and hiking trails starting right on the doorstep. The Alpenarena Hoch Häderich Ski Area can be reached in 7 minutes by car. The self-catering apartments are furnished in Alpine style and feature free WiFi and a south-facing balcony. They also offer satellite TV, a combined living area with a kitchenette, and a private bathroom with
Ferienwohnungen Familie Eberle
Close [x]
Gasthof Ochsen
Hittisau (0.5km from town centre)
The Gasthof Ochsen is a hospitable, family-run inn with a long tradition, situated in the centre of the idyllic village of Hittisau, the most beautiful flower village of Vorarlberg, at 800 metres above sea level. Our country inn is well-known for its traditional cuisine serving natural products from the region, and affords a wonderful view of the mountains. The cosy and modern rooms are all individually furnished. Enjoy easy-going vacations in t
Gasthof Ochsen
Close [x]
Prices from only EUR 62
Ferienhof Dürlinde
Hittisau (0.9km from town centre)
Ferienhof Dürlinde is a 5-minute drive from Hittisau town centre and the local bus stop. Shops, restaurants, bars and cafes can be visited there. The property offers activities for children, including treasure hunts and tracking. Apartments at the Dürlinde have wooden furnishings, a bathroom, kitchenette, dining area, dishwasher, seating area and satellite TV. Some units have a winter garden with mountain views. A bread delivery service is avail
Ferienhof Dürlinde
Close [x]
Prices from only EUR 70
Ferienhaus Lila
Hittisau (1.1km from town centre)
Offering a garden, Ferienhaus Lila is situated in Hittisau, 43 km from Sankt Anton am Arlberg. Oberstdorf is 24 km away. The accommodation features a flat-screen TV with satellite channels. Some units feature a seating area and/or balcony. There is also a kitchen, fitted with an oven, fridge and stovetop. There is a private bathroom with a bath or shower in every unit. Towels are featured. Ferienhaus Lila also includes a barbecue. The area is
Ferienhaus Lila
Close [x]
Prices from only EUR 44
Haus Hagspiel
Hittisau (1.2km from town centre)
Haus Hagspiel is a working farm with lots of animals, enjoying a quiet, hillside location 2 km from Hittisau and 10 km from the Hochhädrich Ski Area. You can enjoy a wide range of home-made products. All rooms and apartments at Haus Hagspiel have a private bathroom and a TV. The apartments come with a fully equipped kitchen. The owner's daughter is a ski instructor and thus you can book skiing lessons on site. The Hochädrich and Balderschwang s
Haus Hagspiel
Close [x]
Prices from only EUR 39
Haus Eberle
Hittisau (1.7km from town centre)
Set in Hittisau,100 metres from a ski lift and 1 km from the village centre, Haus Eberle offers a self-catering accommodation with free WiFi, free ski storage and access to a shared terrace and garden. Free parking spaces are available on site and a bus stop is 200 metres away. The apartments at the Eberle come with stunning views of the surrounding mountains, a well-equipped kitchen and a flat-screen TV with satellite channels. In addition, the
Haus Eberle
Close [x]
Altes Bauernhaus Halden
Lingenau (1.7km from town centre)
Featuring free WiFi and a terrace, Altes Bauernhaus Halden is a holiday home, set in Lingenau. Guests benefit from balcony and a barbecue. Free private parking is available on site. There is a seating area and a kitchen. A flat-screen TV with satellite channels and Blu-ray player is offered. There is a private bathroom with a bath or shower. You can play table tennis at the property, and the area is popular for skiing. Sankt Anton am Arlberg is
Altes Bauernhaus Halden
Close [x]
Familienbauernhof Metzler
Egg (1.8km from town centre)
Set in a picturesque and quiet area, Familienbauernhof Metzler offers apartments with a balcony or a terrace. You can buy regional and homemade products like honey, cheese and liquors on site. The Schetteregg Ski Area is a 10-minute drive away and Hittisau is 3 km from the guest house. Every apartment comes with a fully equipped kitchen or kitchenette. The apartments further feature a living area with sofas and a flat-screen satellite TV. A bath
Familienbauernhof Metzler
Close [x]
Hittisau (1.9km from town centre)
Grubhof is within 5 km of Hittisau town centre, the Alpenarena Hochhädrich ski area, a public swimming pool, a supermarket and a restaurant serving traditional Austrian cuisine. The Grubhof apartment has 3 bedrooms, a flat-screen TV with satellite channels, a living room, fully equipped kitchen and a bathroom with a shower and toilet. The property has a ski storage room, a garden with barbecue facilities, an infrared cabin and a natural swimmin
Close [x]
Hotel Gasthof Wälderhof
Lingenau (2.5km from town centre)
Featuring a gourmet restaurant, Hotel Gasthof Wälderhof is a 7-minute walk from the centre of Lingenau and offers you rooms and apartments in modern Alpine style, free Wi-Fi and free private parking. Individually decorated, all rooms offer panoramic views of the surrounding meadows and mountains are come with an elegant bathroom and a flat-screen TV with satellite channels. A heated ski storage room is available on site. A buffet breakfast can
Hotel Gasthof Wälderhof
Close [x]
Prices from only EUR 67
Genusshotel Alpenblick
Lingenau (2.8km from town centre)
Situated in Lingenau amid the Bregenzerwald Forest, Genusshotel Alpenblick Alpenblick has a ski bus stop right in front of the door. It offers fine cuisine and free Wi-Fi. All rooms have a satellite TV, a minibar and a private bathroom with a hairdryer. They are accessible by elevator. A baby changing room and a ski storage room are available on site as well. Vorarlberg specialities and international cuisine are served in the restaurant of the
Genusshotel Alpenblick
Close [x]
Prices from only EUR 69.5
Hotel Gasthof Adler
Lingenau (2.9km from town centre)
The family hotel Gasthof Pension Adler is situated in one of the most beautiful mountain regions of Austria - the Bregenzerwald in Vorarlberg (35 km from Bregenz). Our family hotel is situated in the centre of the small, typical Austrian village Lingenau and is built in the traditional style of the Bregenzerwald. Whether you spend your holiday in summer or in winter - our guests are given a very warm welcome at the Gasthof Adler, where the Fehr
Hotel Gasthof Adler
Close [x]
Prices from only EUR 55
Hotel Gasthof Löwen
Lingenau (3.1km from town centre)
Located amid the quiet Bregenz Forest region, family-run Hotel Gasthof Löwen is situated in the town centre of scenic Lingenau. It offers free Wi-Fi access and a rich breakfast buffet. All bright and spacious rooms provide king-size beds, private bathrooms and satellite TV. Most of them also have a balcony. The restaurant of the Gasthof Löwen serves traditional Austrian specialities and international cuisine in the rustic dining rooms or outsid
Hotel Gasthof Löwen
Close [x]
Prices from only EUR 70
Krumbach (3.2km from town centre)
Located in the quiet village of Krumbach in a sunny spot in the valley. The good standard property (200 m) is on the 3nd floor. Set in 1ha. of land Lawn with garden furniture.
Close [x]
Ferienhaus Sonnegg
Egg (3.3km from town centre)
Ferienhaus Sonnegg has a sauna and infrared cabin that can be used by guests free of charge. The Schetteregg cable car is 2.5 km away, and a supermarket, restaurant, Egg village center and a public outdoor pool are within 7 km. Apartments at the Sonnegg have a terrace with a seating area and parasol, a flat-screen TV with satellite channels, a fully equipped kitchen, and a bathroom. Cleaning products are available, and a bread delivery service i
Ferienhaus Sonnegg
Close [x]
Hotel St. Hubertus
Egg (3.6km from town centre)
The Sankt Hubertus is situated 3 km from the Schetteregg Ski Area. The ski bus stops 100 metres away and can be used free of charge with a ski pass. Wellness facilities include a spa garden, an indoor swimming pool, a massage parlour, and an infrared sauna. Each room and apartment at the Ferienidylle St. Hubertus has its own balcony. The décor features characteristic Alpine furniture with wood carvings. Guests can make use of the spacious gym,
Hotel St. Hubertus
Close [x]
Prices from only EUR 89.28
Vitalhotel Quellengarten
Lingenau (3.7km from town centre)
Set amidst the hills of the Bregenz Forest, Vitalhotel Quellengarten features an indoor and an outdoor pool. The large spa area offers various saunas and a steam bath. Rooms at the Quellengarten offer satellite TV and a bathroom with bathrobes and a hairdryer. Some rooms have a balcony. A rich breakfast buffet with many regional and organic products is served in the morning. The restaurant offers a selection of regional, international and vege
Vitalhotel Quellengarten
Close [x]
Prices from only EUR 91
Apartment Fohren
Schetteregg (4.1km from town centre)
Apartment Fohren offers pet-friendly accommodation in Schetteregg. The property features views of the mountains is 39 km from Sankt Anton am Arlberg. Free WiFi is featured throughout the property. The kitchen comes with a microwave and a refrigerator, as well as a coffee machine. A TV is available. Free private parking is also available on site. Oberstdorf is 22 km from Apartment Fohren, while Lech am Arlberg is 27 km from the property.
Apartment Fohren
Close [x]
Results: 1 to 20 of 184
Back to top ^^
Sorry we could not find a hotel. Perhaps there are no hotels which meet your search criteria. Please change the filters and try again.
Tips -
Zoom in by clicking the icons
- Group of hotel properties (Click to zoom in)
- Hotel property (Click for more details)
Back to top
Site map
Contact us
Holiday websites


text:
Jacques Torres' A Year in Chocolate by chocolatier Jacques Torres, features tantalizing recipes like Chocolate-Covered Fortune Cookies; Molded Chocolate Bunny; and Pumpkin Chocolate Cake.
Makes one 8-inch Bundt cake
Rich with the flavors of fall and winter, this sensational snacking cake is aromatic with spices, moist with mellow pumpkin, and studded with chocolate, cranberries, and nuts. Easy to make for the holiday season when lots of entertaining is on the agenda, it is also a terrific keeper (refrigerated or frozen) for last minute get-togethers. For an even deeper chocolate flavor, substitute 1/4 cup Dutch-processed cocoa for 1/4 cup of the flour.
Preheat oven to 350°F. Lightly butter and flour a 6-inch bundt pan. Set aside.
Place the butter in the bowl of an electric mixer fitted with the paddle attachment. Beat on medium speed to just soften. Add the brown sugar and beat for about 4 minutes, or until very light and creamy. Reduce the speed to low and add the eggs, one at a time, beating well after each addition. Add the pumpkin and beat to blend.
Combine the flour, baking soda, cinnamon, nutmeg, cloves, and salt and, with the motor off, sift the dry ingredients into the pumpkin mixture. Turn the speed to low and beat to incorporate the dry ingredients into the pumpkin mixture. When well-blended, remove the bowl from the mixer and, using a rubber spatula, fold in the chocolate, cranberries, and nuts.
Scrape the batter into the prepared pan. Bake for about 40 minutes, or until a cake tester inserted near the center comes out clean.
Remove from the oven and invert onto a wire rack. Remove the pan and allow the cake to cool at room temperature.
When cool, transfer the cake to a serving plate, placing the decorative side up. Place the confectioners' sugar and cocoa powder in a fine-mesh sieve and, tapping gently on the side of the sieve, lightly dust the cake with the sugar-cocoa mix. Or, for a more elegant cake, omit the dusting and drizzle the cooled cake with Chocolate Glaze (below). Cut into slices and serve.
The cake will keep, covered and refrigerated, for up to 4 days or frozen for up to 3 months.
Place the chocolate in a heatproof bowl. Set aside.
Place the cream in a medium heavy-bottomed saucepan over medium heat and bring to a boil. Immediately remove from the heat and pour over the chocolate. Let rest for a few seconds and then begin incorporating the cream into the chocolate by mixing with a rubber spatula.
When well blended, drizzle over the cooled cake. Let stand for a few minutes to harden slightly before cutting.
Buy Jacques Torres' A Year in Chocolate
This page created January 2009
The FoodWine
Main Page
Kate's Global Kitchen
Kate's Books
Cookbook Profiles
Global Destinations
Holiday & Party Recipes
I Love Desserts
On Wine
Caffeine and You
Cooking with Kids
New Green Basics
Conversions, Charts
& Substitutions
About FoodWine
Contact Info
Privacy Statement
Anatolia: Turkish Recipes
Bar Tartine
The Beer Bible
Beetlebung Farm Cookbook
Bird in Hand (Chicken)
Bitter: Flavor
Bob's Joke Burgers
Cooking Light
Darjeeling Tea
Dinner at Home
Everyday Baker
Fast Food (Andrew Weil)
Flavor Flours
Food 52 Genius
The Food Lab
Garden Recipes
Grandmas' Recipes
Hartwood: Yucatán
Humane Butchering
Heritage Southern Recipes
Jemima Code African Recipes
Kitchn Cookbook
Liquid Intelligence
Near & Far World Recipes
NOPI Restaurant Cookbook
Oxford Companion to Wine
Phoenix Claws: Chinese
Picnic: Recipes
Soda Politics
Southern Recipes
The Third Plate
V Is for Vegetables
Vegetarian India
What Katie Ate
The Whole 30
Whole Food Kitchen
Yucatán Recipes
Zahav Israeli Cooking
Copyright © 1994-2016,
Forkmedia LLC


text:
Is Ditch Witch of Maryland incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
Are these details correct?
Ditch Witch of Maryland is proud to service Maryland, Northern Virginia, West Virginia, and Delaware.
We offer a full line of products which include Trencher, Piercing Tool, Directional Drill, Subsite Locator, Backhoe,
Track Trencher, Tool Carrier, Cable Plow, Pipe Burster and Mini Skid Steer.
In addition to Ditch Witch underground construction equipment, we also represent
Sullivan air compressor, Piercing Tool , Allied Piercing tool, IHI Mini Excavator, Hudson Brother trailer, , Terramite Sweeper and Dynapac compactor/ tamper. Along with ready fit attachments for your Bobcat, Toro or other make skidsteer.
Our also carries a full line of Genuine Ditch Witch parts along with Baroid Drilling Products, Railhead, and ready fit parts for your Vermeer or other make construction equipment.
and ready fit parts for your Vermeer or other make construction equipment.
We also have a large assortment of
Whether its , , or training, Ditch Witch of Maryland can do it all! Let us knowhow we can help!!
Products & services
We offer a full line of products, including Trenchers, Piercing tools, Directional drills, and Mini skid steers. Read more
Is Ditch Witch of Maryland in 12975 Livestock Road, Sykesville MD 21784 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
We have more Financing services in Sykesville MD available on Hotfrog US. You can update your search for Sykesville Financing by location, keyword or service options.
Small Business Hub
Sharing tips, ideas and advice to help grow your small business
Your profile without ads
Have you considered upgrading to Hotfrog AdVantage? No competitor advertising means exclusive focus on your business. You take centre stage.
Create your free Hotfrog business profile
Follow Hotfrog on:
Share on:
Hotfrog Small Business Hub


text:
Home » Adoptions 2015 » Tallulah has been adopted!
Recent Posts
Visit us!
Visitors are crucial to our rescue center – providing much needed help and allowing us to properly care for our rescued Mustangs. Learn More
We're On Facebook!
Hit Like and say Hi!
Upcoming Events
Gascon Horsemanship ClinicApril 15 @ 10:00 am - April 16 @ 5:00 pm
Save a Horse DayApril 22 @ 1:00 pm - 5:00 pm
McIntosh Equine Horsemanship ClinicApril 29 @ 10:00 am - April 30 @ 5:00 pm
Donate to Help the Wild Horses
About the WHRC
The Wild Horse Rescue Center (WHRC) is dedicated to the preservation of America's wild horses. We rescue, rehabilitate and find new homes for mustangs and burros. We provide educational clinics and seminars to the public. We are based in Mims, Florida.


text: We make more than 50 different flavors of gelato and sorbet in all, with a rotating array of 18 flavors available in the store daily. At the Split Banana, we like to pick 3 flavors – based on your feedback and seasonal taste – to showcase as Flavors of the Month. This way you can be sure these flavors will be available, even as we rotate the other flavor selections in and out. Mark your calendars and bring your friends to enjoy these fan favorites!


text:
Are you going after too many different goals right now?
Do you have a long list of projects that you rarely make any progress on?
There's no "perfect" number of goals … but, generally, the fewer goals you have, the higher your chances of succeeding with each.
Two Approaches to Goal-Setting
Imagine two people, Alice and Bob. They're a couple; they have two kids, and they both have day jobs....
Via Anita, David Hain, Richard Andrews


text:
Tropical Fish Keeping - Aquarium fish care and resources (http://www.tropicalfishkeeping.com/forum.php)
- Coral and Reef Creatures (http://www.tropicalfishkeeping.com/coral-reef-creatures/)
- - hermit vs. crab (http://www.tropicalfishkeeping.com/coral-reef-creatures/hermit-vs-crab-69442/)
hermit vs. crab
I was just wondering which would be better for a clean up crew emeral green crabs or hermit crabs. I have 65 gallon.
Posted via Mobile Device
without knowing the conditions and what your trying to conrtol.its hard to give you to much of an opinion..but i like both..a couple emeralds and a crew of hermits...there are alot of hermits out there so choose wisely.
I am just trying to control uneaten food, fish waste and algae
Posted via Mobile Device
hermits seem more versatile to me...red leg,blue leg, scarlet, holloween,those are some good hermit candidates..
I know there are some that do not like crabs, but I personally have a ton of hermits in my reef, along with some large Mexican turbo snails for algae control. The hermits don't do a very good job on algae, but they do a great job with detritus and uneaten food.
Ya I just got 10 red leg hermits and 3 emreral and 2 of the emeral crabs have really done a number on the algae already
Posted via Mobile Device
sweet man ...just remeber to under stock as the food stuffs will be eaten up sooner than lateras far as algaes go.
|All times are GMT -5. The time now is 01:28 PM.
Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2017, vBulletin Solutions, Inc.
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.


text:
Log In
Gives you full control over the WordPress excerpt: change the length, the ellipsis [...] and surrounding markup.
Download Version 0.2.1
Requires: 2.8 or higher
Compatible up to: 2.8.4
Last Updated: 7 years ago
Active Installs:
Got something to say? Need help?
Translate Better Excerpt
0 people say it works.
0 people say it's broken.
Log in to vote.


text:
Summer Stroll on 3rd Avenue
Join the Merchants of Third Avenue along with Senator Golden as 3rd Avenue from 82nd to 89th Street is transformed into a pedestrian plaza filled with ambient lighting, musicians, performers and artists. Take a leigsurely stroll along the avenue and experience opera, jazz or ballet. Sit, relax and enjoy a delicious meal, as our restaurants expand their outdoor seating.
How a Bill Becomes LawLearn More
Senator has new policy idea
Idea is drafted into a Bill
Bill undergoes committee process
Senate and Assembly pass bill
Bill is signed by Governor


text:
Kids and Teens People and Society Holidays and Special Days Christmas Santa Claus
This category is for sites about Santa Claus, otherwise known as St. Nick.
Subcategories 2
Sites 9
Animated Santa Claus
[ Kids ] Give an elf the gift of clothing, send an e-card to a friend, or read an animated fairy tale.
Awesome Stories - St. Nicholas: The Real Santa Claus
[ Kids/Teens/Mature Teens ] Take a virtual journey to the world of the real Santa Claus whose name was Nicholas of Myra. Learn what he did to help children in the 4th Century.
NORAD Santa Tracker
[ Kids/Teens ] Follow Santa as he makes his magical journey to earth from the North Pole. Includes games, video, music and stories.
North Pole Journal
[ Kids ] Color pictures, play games, leave messages for Santa, and listen in on what is happening in his workshop.
[ Kids ] See Santa getting ready for his Christmas Eve ride. Enjoy free holiday games, stories, and music. Email Santa and he will email you back.
Santa Claus at Claus
[ Kids/Teens/Mature Teens ] Check your naughty or nice rating, play games in elf school or print your honorary elf diploma. E-mail Santa or track his journey Christmas Eve.
Santa Claus at the Northpole
[ Kids ] Enjoy Christmas at the North pole in Santa's Secret Village. Send a letter to Santa or a Christmas card to a friend. Find yummy recipes, stories, activities and games.
Santa Claus Christmas Games
[ Kids ] The world of Santa Claus, with christmas games, ecards, an advent calendar, and screensavers.
[ Kids/Teens/Mature Teens ] A network of short films. Features elf adventures, Christmas around the world, foods, Santa, northern lights, and greeting cards.
Last update:December 24, 2016 at 18:31:47 UTC
People and Society
School Time
Sports and Hobbies
Teen Life
Your Family
All Languages
"Kids and Teens ... Santa Claus" search on:
Google - KidsClick! - Yahoo


text:
IDS attend Smart Shield 2013, the Army Corp of Engineers' Open Day
24th June 2013, Rome. IDS attended Smart Shield 2013, an open day hosted by the Italian Army Corps of Engineers in Cecchignola, near Rome. The main theme for the day was the concept of "Force Protection"; the role of the Army Corps of Engineers remains essential in attempting to minimize the risks involved for military contingents engaged in missions abroad and there is therefore a strong emphasis on continuous training and innovative technologies.
Selected small and medium Italian and international enterprises were invited to display and demonstrate systems designed to aid military ground in their various missions, especially in the fields of military engineering and the security of personnel in operational theaters.
Solutions and prototypes on display at the IDS stand
IDS displayed the capabilities of our current GPR and interferometric radar systems for civilian applications and described how these technologies could possibly be used in the future to develop systems designed to tackle specific military tasks. IDS also exhibited a range of innovative new prototype systems and developments to senior members of the Italian military, including the Commander of the Land Forces Command, Army General Roberto Bernardini. These included systems for detecting the location of incoming hostile fire, especially from snipers, and for looking through walls using advanced radar technology.
General Roberto Bernardini (on the left) visiting the IDS stand
As well as allowing IDS to showcase our range of technologies and solutions, the open day allowed IDS to improve our understanding of the needs and requirements of the Italian land forces in modern day asymmetric battlefield environments such as currently found in Afghanistan. In his closing speech the Commander of the Corps of Engineers, General Antonio Li Gobbi, stressed the importance of collaboration between the military forces involved in theater and companies in the sector of defense
Finally we would like to thank the Italian Army Corps of Engineers, Arma del Genio, for their hospitality and for inviting IDS to share the day with them.


text:
Dynamic Widgets gives you full control on which pages a widget will display. It lets you dynamicly show or hide widgets on WordPress pages.
Display a listing of posts using the [display-posts] shortcode
Remove clutter, save space: display and hide additional content in a SEO friendly way by wrapping content in an [expand] shortcode.
Simple, stylish, and compact plugin for displaying Instagram photos in a sidebar, post, or page.
Easily add custom CSS, JavaScript, HTML and PHP code to unique CJT code blocks and assign them wherever you want.
Add beautiful, fully customizable post tiles or tiled galleries anywhere on your WordPress site easily with WP Tiles.
A plugin for displaying quotes or testimonials or other rotating snippets of content.
The **Show IDs** plugin displays the ID of all posts, categories, pages, taxonomies, users, tags, and more.
Display Tweets is an easy to use, future proof Twitter feed plugin that uses PHP to make requests to the v1.1 Twitter REST API.
Accordion And Collapse is the most easiest drag & drop accordion builder for WordPress. You can add multiple accordion and collapse with this.
This plugin allows you to hide text under the tags [spoiler]your text[/spoiler].
Numbers comments sequentially and hierarchically; handles comments which are threaded, paged and/or reversed. Coders can call the function directly.
Easily add expand and collapse functionality to any WordPress theme. No coding skills required! Beautifully simple UI. Save space with this plugin for
Plugin to show or hide portions of a Page or Post based on specific date/time characteristics.
Displays the current PHP version in the "At a Glance" admin dashboard widget.
Accordion Shortcode & Widget is most easiest drag & drop accordion builder for WordPress. You can add unlimited Accordion and FAQ with unlimit
The plugin enables any user to modify the default order by which posts are ordered when they are displayed on any page of their blog.
The best wordpress "Read more" plugin to help you show or hide your long content.
Display your live eBay listings, profile and feedback information on your site in just a few clicks.
Lets WordPress users display lists of files in their pages and posts in a myriad of interesting ways.
Creates a shortcode to display the date/time when a post/page was last updated (with optional formatting).
Integrate our data driven and automated performance display plugin into your WordPress platform and serve your users targeted ads in real time.
Get last X number of posts from a selected RSS feed. Default is last 5 items. Includes shortcode for listing feed items on posts or pages.
Preserve formatting of code for display by preventing its modification by WordPress and other plugins while also retaining whitespace.
This plugin allows you to show and hide specific portions of content within a post or page. Visitors can then use custom show/hide links to show or hi
Display hierarchical post types and taxonomies a single level pages at a time.
Search Live supplies integrated live search facilities and advanced search features.
Replaces the username for author permalinks with the users display name. Returns a 404 if the author permalink using the actual username is used.
Add-on to Advanced Custom fields (ACF) for showing multiple ACF fields in a single row on front-end. Great for short text fields or having 2x date fie
Ajax powered admin page to show, edit, add, and remove user meta. Choose dropdown list by User Login, ID, or Display Name.


text:
Click here for more information about the rec program and schedules.
We strive to offer affordable, high-quality basketball opportunities for Duluth-area youngsters in grades 5-8. In doing so, we hope our players learn the core values of teamwork, accountability, hard work and perseverance. We will turn no youngster away.
Girls' Game
Wisconsin 78
Minnesota 70
MVP: Chelsea Mason of Mountain Iron-Buhl, MN
Boys' Game
Wisconsin 106
Minnesota 101
MVP: Rece Dietrich of Barron, WI
Click HERE for more Border Battle info!


text:
By Lisa Halverstadt |
Balboa Park is known as San Diego's crown jewel. Maintaining it takes a lot of work.
The nearly 150-year-old park and those who care for it face significant challenges in ensuring the park remains the iconic destination it is today.
Some of the park's beloved trees have fallen prey to the drought, recent storms and old age. Many of the park's historic facilities are crumbling and in need of repairs. And one of the top architects of some of the city's long-range plans for the park estimates about half of them remain unfulfilled – and unfunded.
Here's a breakdown of five of the biggest challenges confronting Balboa Park.


text:
Looks like The Broadway Building is no longer available on Rent.com which means this information is likely out of date.
Our property is conveniently located near everything! With a walk score of 98, we are positioned close to grocery stores, restaurants, cafes, nightlife, bookstores, close freeway access and on major bus routes.The beautiful grounds feature lush landscaping and natural light, spectacular Seattle city skyline. Mt. Rainier, and Cal-Anderson Park views.. Units include the following great amenities: floor-to-ceiling windows, high ceilings, wood vinyl flooring in kitchen and entryways, new appliances and two different finish options to choose from. Our open floor plans feature living spaces that frame views of Seattle's skyline or the expansive Cal-Anderson Park located just outside your door. Venture downstairs to an array of retail space including Panera Bread, Yogurtland, Emerald City Smoothie, Gamestop, Genki Sushi, Z Pizza, and Cure Wine Bar. Directly next door you can find Blick Art Supply, Sugar Pill Apothecary, and Rock Box Karaoke Bar. With our central location, you really can have it all! The Broadway Building - No Better Place to Live. Call today to schedule your personal tour!
Lease Terms: 12 month leases.
Pet Policy: 50 lbs max. 2 pets max. Pet Rent: $25. Restricted Breeds: Pit Bulls, Rottweilers, Presa Canario, German Shepherds, Huskies, Malamutes, Dobermans, Chowchows, St. Bernarda's, Great Danes, Akitas, Terriers (Staffordshire), American Bull Dog, Any hybrid or mixed breed of one of the aforementioned breeds. Refundable Deposit: $250. Non-refundable Pet Fee: $250.
Cats Allowed. Dogs Allowed. Call for service animal policy.
94 units
Don't have a Rent.com account? Create one.
Creating an account allows you to acccess your saved and contacted properties on any device. Already have an account?
Log In
We are experiencing technical difficulties at the moment. Please try again later.


text: Item is not available Find Another One Others Looked At... .50 Beowulf 16" AR Platform Complete Upp... SELLER: Ridgeback 0 $1,299.99 Full Size Bronze 12 lb Mountain Howitzer... SELLER: buckstix 0 $10,000.00 AAC 762-SDN-6 7.62 NATO or .300 BLKOUT S... SELLER: Ammo And Arms 1 $649.99 Rebel Yell Army Predator Facet Camo Heav... SELLER: East Coast Gun Shop 1 $349.99 Ballistic Advantage 14'5" Modern Series ... SELLER: SSTDEFENSE 1 $145.00 TSC 6XC FLUTED Accuracy International Ba... SELLER: Brotherhood Arms 57201 1 $950.00 Non Guns Barrels New Thompson Contender Barrel Extras | 799 | 0 | Lc | 406.2605ms New Thompson Contender 45/70 Barrel + Extras For Sale from JohnsGuideService | No feedback Yet View | Verified Seller View Sellers Items This item is no longer available. Description Shipping and Payment More Info i recently took this in on a trade as i had someone who said they wanted it, but they changed there mind. what we have is a new 23" blued thompson center contender 45/70 barrel. no frame rubs, and comes with a redfield heavy duty 3 ring scope mount and rings,3x9 tasco rangefinder scope (i put the scope on , but havent shot the barrel to line it up). setup also comes with around 100rds of 45/70 brass (some new, some once fired), a box of hornady 300gr XTP bullets for reloading, and a set of RCBS reloading dies . would trade/part trade . looking for bull high polished 16" BLUE contender barrels (with dies a plus!),blued 23" 6.8 remington SPC barrel,older style stainless contender frame,etc.ONLY PISTOL BARRELS I MIGHT BE INTERESTED IN ARE BLUED BULL 10" AND 12" IN 221 FIREBALL.17-222, 22 K hornet or 222 remington.open to alot of different calibers in the 16:,so feel free to email me and let me know what you have. NOT INTERESTED IN ANY STAINLESS STEEL BARRELS.might also consider trade on single action 22 pistol, stainless scope mount and stainless quick detach scope rings for S&W 500,decent blued variable power pistol scope ,randall made knife, ,aitor jungle king I or desert king knife (with sheath and kit), aitor jungle king II knife (with sheath and kit),buck 184 survival knife, or ???..open to alot of different suggestions...a new in box 45-70 contender barrel costs around $240+...then if you add the cost of brass,dies,bullets,mount and rings,scope,etc your getting one HELL of a deal. its like buying the barrel, and getting all the other stuf free! pri. shipping and insurance included in purchase price. trades are responsible for there own shipping charges. Trades Accepted: No Condition: Never fired Location: CA Share Item Item #: 978067342 This item is no longer available. Price: Shipping: See Description (or Arrange local transfer) Accepted Payment Methods: Contact Seller Returns: No Returns JohnsGuideService Seller Since: Nov. 2008 Seller Level: Basic This seller is NOT an FFL City: mcarthur State: CA Your Recently Viewed Items


text:
This page gives brief biographies of some of the Few. As more are added, the diversity of nationalities, trades and ranks amongst the airmen who qualified for the Battle of Britain Clasp will become clear.
The biographies are based on, though not the same as, the entries for these men in the new edition of Men of the Battle of Britain by Kenneth G Wynn, now being prepared for publication. The rights to this book are owned by the Battle of Britain Memorial Trust and a publication date will be announced as soon as possible. The traditional style of the book will remain.


text:
Jane's Addiction and The Flaming Lips to Headline Doheny Days
The lineup...so far
Boy, oh boy, this year's edition of Doheny Days is looking mighty strong. Yesterday, KROQ confirmed the lineup for this year's festival, which will be taking place on Sept. 8-9 at Doheny State Beach in Dana Point.
Headlined by Jane's Addiction and The Flaming Lips, the lineup for the alt-indie-reggage festival (sponsored by KROQ) includes Edward Sharpe & The Magnetic Zeros, Jimmy Eat World, Rebelution and Beats Antique. This is just the start as the festival's website promises more acts will be announced soon.
We're glad to see this surf-side festival breeze back into town . Revived last year by Omega Evens after a 7-year absence, last year's event was a success drawing artists as diverse as Ben Harper, Weezer and Cake to the beach. But this year's lineup is shaping up to be much stronger and a larger draw to the beach.
With a mix (so far) of alternative, indie and reggae, there promises to be a little bit of something for everyone and this could be the strongest show of the late summer in Orange County. The eclectic lineup is essential to capture the diverse tastes in music that makes up the county and turn this festival into an event that music fans can look forward to every September.
Upcoming Events
The Virus, Agression, Corrupted Youth, Raukous, Tanzler, Capital Waste
TicketsTue., Feb. 28, 8:00pm
Anderson .Paak & the Free Nationals
TicketsThu., Mar. 2, 7:00pm
Post Malone
TicketsThu., Mar. 2, 8:00pm
Chingo Bling
TicketsThu., Mar. 2, 8:00pm
Over the past few years, beachfront festivals have been popping up all over the country, especially in the Southeast, so it makes sense that Doheny Days is making a comeback. And allow us to thank them in advance for hosting The Flaming Lips' first OC appearance since 2003 at the Verizon Wireless Amphitheater in Irvine. Watching Wayne Coyne and company execute their trippy stage show on the beach is already worth the price of admission.
Tickets go on sale this Friday at 10 a.m. through the Omega site, though there's a daylong pre-sale on Thursday exclusively for KROQ Street Team members. Prices for weekend passes: $80 for general admission, $175 for VIP and $350 for Lounge level.
Follow us on Twitter @ocweeklymusic @danielkohn and like us on Facebook Heard Mentality
Get the Music Newsletter
Keep your thumb on the local music scene each week with music news, trends, artist interviews and concert listings. We'll also send you special ticket offers and music deals.
In Case You Missed It
Upcoming Events
Beatles VS Stones - Abbey Road & Satisfaction
TicketsSun., Feb. 26, 7:30pm
The Pesos with Cola Boy & Fataljamz
TicketsSun., Feb. 26, 9:00pm
Kim & the Created
TicketsMon., Feb. 27, 9:00pm
Social Distortion
TicketsTue., Feb. 28, 7:00pm
Sponsor Content