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The broad objective of this proposal is to understand posttranscriptional control of early animal development. One mechanism that regulates maternal mRNA expression is cytoplasmic polyadenylation. CPEB, a sequence-specific RNA binding protein, is at the heart of this process;it nucleates a number of factors on specific mRNAs and controls translation by modulating poly(A) tail length. Polyadenylation does not happen en masse, but instead occurs in sequential waves that are most evident during oocyte maturation in Xenopus. The first wave happens at meiosis I (MI) while the second occurs at meiosis II (MII). One determinant for first or second wave polyadenylation is the amount of CPEB in the cell. During the MI to MII transition, some of the CPEB is destroyed, which is important for second wave polyadenylation. CPEB destruction requires multiple cdk1 phosphorylations, subsequent ubiquitination, and Pin1 (peptidylprolyl cis/trans isomerase) activity. Pin1 activity increases during meiosis and binds and controls CPEB destruction. Moreover, Pin1 mediates CPEB destruction in mammalian cells as well. Pin1 also binds phospho-maskin, the CPEB- and eIF4E- binding factor that coincides with maskin phosphorylation and dissociation from eIF4E, allowing initiation complex assembly. The goals of the first specific aim are to determine how Pin1 mediates CPEB destruction and MI to MII transitioning, and whether it regulates translation by disrupting the maskin-eIF4E interaction. The second specific aim intends construct an integrated network map of polyadenylation during maturation. To do so, CLIP (crosslink IP) will be employed;it will identify not only the mRNAs to which CPEB binds, but where on the mRNA CPEB binds. This analysis will define, on a genome wide scale, what constitutes a CPEB binding element (CPE). These experiments will be complemented by the identification of all the mRNAs that undergo cytoplasmic polyadenylation, and which of 2 non-canonical poly(A) polymerases are used. Translational control by CPEB regulates not only early development, but neuronal synaptic cellular senescence as well. Thus, these experiments have important implications of human infertility, neurodegeneration, and cancer etiology.
8. Project Narrative The regulation of gene expression by the protein CPEB controls early animal development, higher brain functions, and anti-cancer mechanisms. Thus, detailed biochemical analysis of CPEB is essential for these critical biological processes, which clearly impacts human health.
|Ivshina, Maria; Lasko, Paul; Richter, Joel D (2014) Cytoplasmic polyadenylation element binding proteins in development, health, and disease. Annu Rev Cell Dev Biol 30:393-415
|Nechama, Morris; Lin, Chien-Ling; Richter, Joel D (2013) An unusual two-step control of CPEB destruction by Pin1. Mol Cell Biol 33:48-58
|Udagawa, Tsuyoshi; Farny, Natalie G; Jakovcevski, Mira et al. (2013) Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nat Med 19:1473-7
|Lin, Chien-Ling; Huang, Yen-Tsung; Richter, Joel D (2012) Transient CPEB dimerization and translational control. RNA 18:1050-61
|Darnell, Jennifer C; Van Driesche, Sarah J; Zhang, Chaolin et al. (2011) FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146:247-61
|Cao, Quiping; Padmanabhan, Kiran; Richter, Joel D (2010) Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition. RNA 16:221-7
|Lin, Chien-Ling; Evans, Veronica; Shen, Shihao et al. (2010) The nuclear experience of CPEB: implications for RNA processing and translational control. RNA 16:338-48
|Kan, Ming-Chung; Oruganty-Das, Aparna; Cooper-Morgan, Amalene et al. (2010) CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol 30:5658-71
|Kim, Jong Heon; Richter, Joel D (2008) Measuring CPEB-mediated cytoplasmic polyadenylation-deadenylation in Xenopus laevis oocytes and egg extracts. Methods Enzymol 448:119-38
|Kim, Jong Heon; Richter, Joel D (2007) RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB. Genes Dev 21:2571-9
Showing the most recent 10 out of 25 publications


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More Videos...
Patrese & Wife - subtitled
She tries hard to convince him to slow down...
Joao Barbosa takes wife on a wild ride around Daytona highbanks in a 2 seater DP.mov
Joao Barbosa takes wife for the 1st time in a ride around Daytona International Speedway at 185mph in a 2 seater Grand Am Daytona Prototype
Foot cam from the HRT V8 Supercar hot lap
This is the foot cam from my hot lap in the V8 Supercar. Just gives you an idea of how intensely V8 drivers actually do drive. I was the passenger. Driver was Neil Crompton.
Michael Schumacher prueba un Maserati Spyder

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text: OverviewBack to top Maxi-Health Research Kosher Vitamins - Maxi Fe25 Iron 25 mg. - 100 Tablets Item# :55272UPC# :753406103102 Brand:Maxi-Health Research Kosher Vitamins Size/Form:100 Tablets Maxi FE 50 Gentle Iron 50 Mg--Replenishes missing iron in pregnant and menstruating women and people suffering from anemia--Essential for the transport of oxygen through the body Low iron levels are the most common and prevalent mineral deficiency. Menstruating and pregnant women, athletes, and vegetarians may all have difficulty getting adequate iron supplies from their food. Anyone not eating a balanced diet is at risk for low iron levels. Iron is critical for transporting oxygen to your muscles. Beacause iron can cause constipation, we at Maxi Health Research® Inc.use the ferrous fumarate form of iron which is the least constipating. To support healthy performance, try FE 50 - the gentle iron supplement.


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before an introduction you felt my honest eyes, our conversation ended with truth, I began with trust me, I until given reason of doubt, I am real.. we together can since the lier.. goodness in us can give that feel,I'm wiser.. I continue with trust me, I
all is forgiven, forgotten with our sincerity.. change is for you to want to live fairly.. it's easy to be yourself, surrounded by truth.. I end with you seeing me the same from the start.. Trust me, I
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Plasmonic Nanoelectronics and SensingBy: Er-Ping Li (author), Hong-Son Chu (author)eBook
£55.31 RRP £76.80 You save £21.49 (28%)Buy eBook
DescriptionPlasmonic nanostructures provide new ways of manipulating the flow of light with nanostructures and nanoparticles exhibiting optical properties never before seen in the macro-world. Covering plasmonic technology from fundamental theory to real world applications, this work provides a comprehensive overview of the field. • Discusses the fundamental theory of plasmonics, enabling a deeper understanding of plasmonic technology • Details numerical methods for modeling, design and optimization of plasmonic nanostructures • Includes step-by-step design guidelines for active and passive plasmonic devices, demonstrating the implementation of real devices in the standard CMOS nanoscale electronic-photonic integrated circuit to help cut design, fabrication and characterisation time and cost • Includes real-world case studies of plasmonic devices and sensors, explaining the benefits and downsides of different nanophotonic integrated circuits and sensing platforms. Ideal for researchers, engineers and graduate students in the fields of nanophotonics and nanoelectronics as well as optical biosensing.
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- publication date: 10/11/2015
- series: EuMA High Frequency Technologies Series
- book language: en
- publisher: Cambridge University Press
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Various Artists
As a self-described introduction to the music of Junior Kimbrough, this tribute album fails spectacularly: These versions of his songs are so radically and haphazardly interpreted that they give only the faintest clue as to what set Kimbrough apart from other venerated bluesmen. And yet almost every eclectic cut here is a winner, from the grits-and-honey-smeared soul of Heartless Bastards' "Done Got Old" to a meltdown rendition of "You Better Run" by a reunited and surprisingly virile Iggy and the Stooges. Will this album make everyone who hears it rush out and buy some real Kimbrough? Hardly. But as a work unto itself, it's almost flawless, dragging some truly tweaked and inspired performances out of the indie-rock glitterati.
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text: TabsArticle Panel on Genetically Modified Organisms EFSA Journal: EFSA Journal 2012;10(11):2934 [36 pp.]. doi: 10.2903/j.efsa.2012.2934 Panel Members: Salvatore Arpaia, Andrew Nicholas Edmund Birch, Andrew Chesson, Patrick du Jardin, Achim Gathmann, Jürgen Gropp, Lieve Herman, Hilde-Gunn Hoen-Sorteberg, Huw Jones, Jozsef Kiss, Gijs Kleter, Pagona Lagiou, Martinus Lovik, Antoine Messéan, Hanspeter Naegeli, Kaare M. Nielsen, Jaroslava Ovesná, Joe Perry, Nils Rostoks, Christoph Tebbe. Acknowledgements: The Panel wishes to thank the members of the Standing 'Environment' Working Group on GMO applications: Salvatore Arpaia , Detlef Bartsch, Andrew Nicholas Edmund Birch, Achim Gathmann, Jozsef Kiss, Antoine Messéan, Joe Perry, Jeremy Sweet, Christoph Tebbe, for the preparatory work on this scientific opinion and EFSA staff: Yann Devos, Andrea Gennaro and Sylvie Mestdagh, for the support provided to this scientific opinion. Contact: email@example.com Type: Opinion of the Scientific Committee/Scientific Panel On request from: European Commission Question Number: EFSA-Q-2012-00819 Adopted: 18 October 2012 Published in the EFSA Journal: 6 November 2012 Affiliation: European Food Safety Authority (EFSA), Parma, Italy Send Print Note: Read the article on the Wiley Online Library Abstract: The EFSA GMO Panel was asked by the European Commission to apply its mathematical model to simulate and assess potential adverse effects resulting from the exposure of non-target Lepidoptera to maize 1507 pollen under hypothetical agricultural conditions, and to provide information on the factors affecting the insect resistance management plan, additional to that in its 2011 Scientific Opinion updating the conclusions of the environmental risk assessment and risk management recommendations on maize 1507. Here, risk managers are provided with additional evidence and further clarifications to those previous conclusions and risk management recommendations. This Scientific Opinion provides background scientific information to inform the decision-making processes; the EFSA GMO Panel reiterates that risk managers should choose risk mitigation and management measures that are proportionate to the level of identified risk according to the protection goals pertaining to their regions. © European Food Safety Authority, 2012 Keywords: 1507, Cry1F, environmental safety, GMO, insect resistance, maize (Zea mays), mathematical modelling, non-target Lepidoptera Print on demand Number of Pages: 36


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Eco-Palms: a sustainable witness for Holy Week
Fair Trade coffee, the installation of recycling bins and community gardens are becoming part of the fabric of Catholic parish life. The rubber meets the road in the call to poverty of spirit not just in the reading of papal encyclicals or in good homilies, but particularly in the priorities parishes make both in programming and purchasing.
Eco-Palms represents one such opportunity for parishes to be the sermon they preach, particularly at the beginning of Holy Week. Eco-Palms represent palms used at Palm Sunday services that are sustainably harvested, and members of the local communities who harvest the palms are guaranteed a fair wage.


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Cheap flights to Stavropol
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Ive been seeing tonnes of bush chickens on my scouts seems to me there is more than last year. I think this year is gonna be better than last anyone else see a rise in there sightings. I also got some great pics of some ruffers.
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Smarties Friend Lockets are the kind of treat that should be saved for a best friend or first love. These large, clip-on, plastic heart lockets fit together to create one heart. One locket says 'Best' and the other says 'Friend.'
Smarties Friend Lockets are great best friend gifts because after the Smarties Candies are long gone, the keepsake hearts can be used to stash away special secrets, trinkets, notes, and other shared treasures.
Each box contains an assortment of 12 purple and red lockets. Each individual package contains 2 half-heart lockets fileld with 5g of Smarties Candy. When both sides are put together, the heart measures 3 inches.
Friend Lockets Friend Lockets filled with Smarties Candy Roll Wafers are one of the sweetest Valentine Treats that we offer. Shop our selection of heart rendering candies here!
- Price: $18.33


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Consider this: viral hepatitis affects an estimated 500 million people around the world - more than 10 times the number affected by HIV/Aids - claiming about one million deaths per year.
One in 12 people live with chronic hepatitis B or C, which together are the leading cause of liver cancer in the world, accounting for 78 per cent of cases. The hepatitis B virus was first discovered in 1965, almost a whole generation before the first reported cases of Aids in 1981.
Yet, hepatitis still lacks the same level of awareness, advocacy and funding as HIV/Aids. Last year marked the 30th anniversary of the war - active and vocal and at times militant - against Aids.
But what of hepatitis? 'Despite knowing about the different forms of viral hepatitis for many decades, and of their impact, the political response to hepatitis B and C lags far behind that of HIV,' said Professor David Thomas, a HIV expert and chief of infectious diseases at the Johns Hopkins School of Medicine in Baltimore, Maryland.
'Surveillance and diagnosis of viral hepatitis remain woefully under-resourced and many countries seem yet to realise that treatment not only saves lives, but the broader public health benefits of treatment often outweigh the cost.'
One advantage of playing catch up is the ability to learn from the past, and that's exactly what the global viral hepatitis community plans to do.
Two days ago, leaders from the community, as well as WHO regional experts, met in Taipei at a symposium organised by the Coalition to Eradicate Viral Hepatitis in Asia Pacific. The meeting, which took place at the 22nd Conference of the Asia Pacific Association for the Study of the Liver, discussed what can be learned from the HIV/Aids experience, in particular lobbying governments to improve public health policies.
A survey by the World Hepatitis Alliance published last year found that most governments from the Western Pacific and Southeast Asia considered viral hepatitis an urgent public health issue, but that the extent and effectiveness of existing policies varied greatly across the region.
Global collaboration and co-operation, as seen from the HIV/Aids experience, are key if any significant progress and public policy reform is to be achieved to reach the goal of eradicating - or at least managing - hepatitis, said Thomas in his keynote speech at the symposium.
'The HIV/Aids advocacy community blazed a trail for all those living with the disease. They have pushed and pushed and they haven't shut up,' said Charles Gore, World Hepatitis Alliance president. 'Their efforts over 30 years offer us in the viral hepatitis community so many important lessons, and it would criminally stupid to ignore them.'


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How To Get Rid Of Wet Towel Smell
When you have finished taking a bath, you use a towel to absorb the water in your skin and hair. But sometimes, if the towel fails to dry, an unpleasant odor may start to emit from it. Damp towels are house for molds, mildew and lots of other bacteria. That is why, if you just leave the towel that you have used unclean and wet, it may start to develop an unwanted smell. Towels are used in keeping your body clean and dry, but what if the towel you are using starts to get smelly and dirty?
Wet towel smell is actually quite common. When you take a bath in the morning and you are already late for school or work, you may be most likely to just leave your towel on the floor or on the bed. This bad habit may cause for it to smell. The worse thing is that when the wet towel gets in touch with other fabrics like your bed sheet, the wet towel smell might even spread. So if you are facing the problem brought about by wet towel smell, here are some things you can do to get rid of it.
Launder as usual
When your towel is already smelly, then it is time for it to be washed. If the smell is not too strong, you can just launder it as usual. Place your towel on the washing machine and pour the right amount of liquid detergent. Let the washing machine run until it has fully cleaned the towel. Rinse it with clean water and then hang outside to dry. It is best if you hang it when the sun is up so that the sun's heat will bleach the towel naturally.
Use fabric conditioner
If the wet towel smell did not go away after washing, you can use fabric conditioner afterwards. You can get this at almost any grocery shop. Simply follow the directions on the label to know how to use fabric conditioner. Note that you should never mix fabric conditioner together with laundry detergent as it may create unwanted streaks on your towel.
Wash with hot water and baking soda
If plain washing your towel is not enough to get rid of the wet towel smell, you can use hot water and baking soda mixture to remove the unwanted odor. Simply heat up some water and pour it in a basin. Sprinkle a generous amount of baking soda on the water and let it dissolve. Then, place the towel on the mixture. Let the towel soak for about an hour or until the smell goes away. Afterwards, you can just wash the towel with water and laundry detergent.
Soak with vinegar
Vinegar is also powerful in removing wet towel smell. It removes not only the wet towel smell, but also the bacteria. Just mix equal amounts of vinegar and water together. Then submerge the towel in this solution. After a couple of minutes have passed, launder the towel normally.
Rub some lemon
Lemon has the same effect like vinegar. Although it is best used on white towels only as lemon have the tendency to lighten up fabrics. Simple wash the towel in clean water first. Then, cut a lemon into two. Use the cut lemon to rub the entire towel. Leave for a few minutes then launder normally.


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text: Revolution has grown its characters more in three episodes than Terra Nova did in a seasonCharlie Jane Anders10/02/12 3:16pm130EditPromoteGo to permalinkA while back, we asked: Is Revolution the new Terra Nova, or the new Supernatural? And now we can say definitively that it's closer to the latter. You may hate this show's magical premise, but you can't deny it's doing the right things to develop staying power.


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Normal brain functioning depends on the establishment of diverse cellular phenotypes. Our research program addresses the mechanisms that regulate differentiation of neuroendocrine cells during development. We use Drosophila molecular genetics to examine the biology of a basic HLH protein called DIMMED (DIMM). Our genetic studies indicate DIMM is necessary and sufficient to promote the cellular features that define neuroendocrine differentiation. First, DIMM is normally expressed by most of the principal peptidergic cells in Drosophila (though not all). Loss-of-function analysis indicates DIMM is not required for cell survival or growth, but is required for these cells to display a proper regulated secretory pathway and normal accumulation of neuropeptides. Gain-of-function studies indicate DIMM can activate the cellular machinery to support peptidergic function in non-peptidergic (i.e., conventional) neurons. At a molecular level, we have shown that DIMM is a transcription factor and that it activates several specific target genes. DIMM is related to the mammalian protein Mist1, a factor implicated in secretory cell differentiation. We hypothesize that DIMM is a dedicated, pro-secretory factor with conserved functions, whose study will lead to a better understanding of the organization and differentiation of neuroendocrine cell types. This research program supports efforts to address human syndromes caused by underlying neuroendocrine disorders, such as stress, or tumor formation in the pituitary or pancreas, and will help guide future programs of stem cell differentiation to generate specific neuroendocrine lineages in vitro. Here we propose five specific aims. First we will derive a consensus DIMM cis-binding site by analyzing in vitro and in vivo several direct target genes. Second, we will extend the list of molecular targets. Third, we will examine DIMM action mechanisms by genetically testing the roles of individual DIMM targets. Fourth, we will test the hypothesis that the paired homeoprotein Eyeless is the principal activator of dimmed. Finally, we will extend our analysis to the mouse model system by examining the hypothesis that the DIMM orthologue Mist1 plays an important role in mammalian peptidergic cell biology.
We study the developmental mechanisms used by neurons to acquire their mature properties. This is significant because the proper functioning of the brain relies on the precision with which different categories of neurons are correctly assembled. In particular, we focus on peptidergic neurons that produce critical signals to coordinate normal physiology and behavior. Our work could help address diverse physiological, emotional and cognitive disorders.
|Park, Dongkook; Li, Peiyao; Dani, Adish et al. (2014) Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. J Neurosci 34:13195-207
|Mills, Jason C; Taghert, Paul H (2012) Scaling factors: transcription factors regulating subcellular domains. Bioessays 34:10-6
|Park, Dongkook; Hadži?, Tarik; Yin, Ping et al. (2011) Molecular organization of Drosophila neuroendocrine cells by Dimmed. Curr Biol 21:1515-24
|Hamanaka, Yoshitaka; Park, Dongkook; Yin, Ping et al. (2010) Transcriptional orchestration of the regulated secretory pathway in neurons by the bHLH protein DIMM. Curr Biol 20:9-18
|Park, Dongkook; Taghert, Paul H (2009) Peptidergic neurosecretory cells in insects: organization and control by the bHLH protein DIMMED. Gen Comp Endocrinol 162:2-7
|Park, Dongkook; Veenstra, Jan A; Park, Jae H et al. (2008) Mapping peptidergic cells in Drosophila: where DIMM fits in. PLoS One 3:e1896
|Shafer, Orie T; Kim, Dong Jo; Dunbar-Yaffe, Richard et al. (2008) Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron 58:223-37
|Park, Dongkook; Shafer, Orie T; Shepherd, Stacie P et al. (2008) The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme. Mol Cell Biol 28:410-21
|Allan, Douglas W; Park, Dongkook; St Pierre, Susan E et al. (2005) Regulators acting in combinatorial codes also act independently in single differentiating neurons. Neuron 45:689-700
|Park, Dongkook; Han, Mei; Kim, Young-Cho et al. (2004) Ap-let neurons--a peptidergic circuit potentially controlling ecdysial behavior in Drosophila. Dev Biol 269:95-108
Showing the most recent 10 out of 30 publications


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I live in a 1960s subdivision generally called an inner ring subdivision. There are two pawn shops that are requesting a permit to operate near our neighborhood. One is located on a busy corridor, and another is just off that busy corridor. As a real estate agent I am aware of the negative impressions that some agents have about neighborhoods where pawnshops and cash checking businesses are evident. If these agents would take the time to investigate neighborhoods such as mine they would see that judging a book by its cover is not an intelligent thing to do. However, in the meantime the possibility of two additional pawn shops will do nothing to help the image of the area.
I do think that as pawnshops proliferate they do provide more places for burglars to trade in their ill gotten gains for cash. This makes it harder for law enforcement to track down stolen goods. I know that some pawn shops are more careful than others in accepting goods, but that fact does not solve the problem of those who will accept most anything without question.
I am interested in finding out if there are any studies that have been done that looked at the effects of pawnshops on existing residential neighborhoods. If you can help, please let me know.


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Miley Cyrus Heads Home, Tyson Returns & More In Our DVD Report For Tuesday, August 18
It's a rare occurrence when Miley Cyrus and Mike Tyson share a spotlight, but that's the way it shakes out as both celebs see their biggest release in years hit store shelves.
In a rather slow week filled mostly with television box sets, Miley's "Hannah Montana: The Movie" is one of two new wide release films dropping on Blu-ray and DVD (the other being the horror remake of "The Last House On The Left," but what's left said about that?). In the pic, Miley's father drags her back home to give the teen superstar some much-needed Southern-style perspective. While it didn't quite match the hype of her 3-D excursion, the first full-fledged "Hannah Montana" theatrical outing managed to please fans of the Disney series, which I guess is all that counts. The film gets a Deluxe Edition with modest extras including behind-the-scenes footage, cast bloopers, a music video and audio commentary from the director (they couldn't wrangle Miley?).
On the other end of the spectrum, about as far away from the pop princess as you could get, Oscar-nominated director James Toback's "Tyson" also arrives on DVD and Blu-ray. A documentary profile of former boxing champ Mike Tyson, the festival-fave film comes highly acclaimed for its in-depth autobiographical look at one of sporting's most tragic figures. The DVD/Blu-ray comes equipped with audio commentary from Toback, and an assortment of featurettes following Toback and gathering his anecdotes on Tyson.
On the retro side, a few personal favorites of mine make their way to Blu-ray. "Go," Doug Liman's twisted high-adrenaline tale of one-night-in-Vegas, makes its way to the high-def format, as does early-80s cult flick "The Last Starfighter." The women out there may also want to note that the deluxe edition of "How to Lose a Guy in 10 Days" also drops.
The remainder of the week belongs to the boob tube. The third season of Showtime's amazing "Dexter" arrives, as does the second season of "Gossip Girl" (click here to watch an exclusive clip from the release), the second season of "Eli Stone," and the and the twelfth season of the neverending "The Simpsons." Also coming out is the first season of FX's gritty "Sons of Anarchy," Ron Perlman's ode to motorcycle gangs which has quickly become one of the more buzzworthy new series on television.
A series of new dates now attached to upcoming releases. Michael Cera and Jack Black's "Year One" hits October 6," Will Ferrell's big-budget summer blockbuster "Land of the Lost" will find itself in stores on October 13, Kevin Costner's post-apocalyptic "Waterworld" (which -- come on -- isn't that bad) arrives October 20, Hugh Grant and Alan Rickman's "Love Actually" will drop November 3, and on the comedy front, "It's Always Sunny in Philadelphia: A Very Sunny Christmas" raises the tree on November 17, the same day that the 70th anniversary edition of "Gone With the Wind" and a new edition of "Fight Club" battle their way onto Blu-ray.


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Australia Trip Planner and Guide
Passport Books, Feb 1, 1998 - Travel - 304 pages
Independent travelers praise this book for its versatility. It offers everything you need to custom-design an itinerary that suits your needs and schedule.
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box by ferry or by car You can do sections of the route or all of it ln the intro
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Aborigine accommodation Adelaide Alice Springs attraction Aussie Australia Overall beaches Brisbane Bruce Highway building Cairns Canberra cane toad Cape caves city centre coast coastal colony Creek cruises east entry explore famous ferry Flinders friendly Gallery gorges Harbour Hervey Bay Hobart House Hunter Valley interesting island Kalgoorlie Keppel Island kilometres Kununurra Lake land lf you want lt's major cards map Nelles Australia Melbourne Motel mountains Museum National Park nearby Northern Nowadays open 9 outback Peninsula Perth PLACES OF lNTEREST pleasant pm daily pool population Port Augusta Port Macquarie Queensland range RECOMMENDED HOTELS RECOMMENDED RESTAURANTS region remote resort River road rock Rockhampton scenery settlement sharks sights SlGHTS & PLACES South Wales spectacular spot Street superb surf swimming Sydney Tasmania there's tion tour tourist town Townsville tralia trip Uluru Victoria walk Western Australia whales wildlife wine


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Rating: 2.0/5 (Total votes: 1)
iMapBuilder is a WYSIWYG mapping software. It is an all-in-one software that creates professional interactive maps quickly and easily without any programming skills or additional software. iMapBuilder provide over 200 map templates such as world countries, united states and europe map, you can create regional map and heat map in minutes, and annotate the map with markers, lines, custom regions.
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