text:
[Date Index] [Thread Index] [Author Index]
NotebookPrint versus File->Print
Hello! I have a very curious printing problem. Cells of one particular style print differently when I use the menu option "File->Print..." as compared to running a NotebookPrint[]. The cell style is called "Itemize" which is pretty much a straight derivation from the "Text" style in the system stylesheet Default.nb. The only difference are a wider left margin and a cell dingbat (a small filled circle). For reference, the style defs are enclosed at then end of this message. Printed with NotebookPrint[] those cells print just an inch or so wide. Printed from the menu "File->Print..." the cells span the full page width, as I would like. Anybody knows what could be causing this difference? Even better, how to fix this so I can print automatically? Thanks alot!!! Henrik Weimer Cell[StyleData["Itemize"], CellDingbat->"\[FilledSmallCircle]", CellMargins->{{36, 10}, {5, 5}}, TextJustification->1, Hyphenation->True, HyphenationOptions->{"HyphenationCharacter"->"\[Hyphen]"}, LineSpacing->{1, 3}, ParagraphSpacing->{0, 12}, CounterIncrements->"Text", FontFamily->"Times"] Cell[StyleData["Itemize", "Presentation"], CellDingbat->"\[FilledSmallCircle]", CellMargins->{{36, 10}, {8, 8}}, TextJustification->1, HyphenationOptions->{"HyphenationCharacter"->"\[Hyphen]"}, LineSpacing->{1, 5}, ParagraphSpacing->{0, 12}] Cell[StyleData["Itemize", "Condensed"], CellDingbat->"\[FilledSmallCircle]", CellMargins->{{36, 10}, {4, 4}}, TextJustification->1, HyphenationOptions->{"HyphenationCharacter"->"\[Hyphen]"}, LineSpacing->{1, 1}, ParagraphSpacing->{0, 4}] Cell[StyleData["Itemize", "Printout"], CellDingbat->"\[FilledSmallCircle]", CellMargins->{{36, 0}, {4, 4}}, TextJustification->1, HyphenationOptions->{"HyphenationCharacter"->"\[Hyphen]"}, ParagraphSpacing->{0, 6}]


text:
with a positive attitude
Market analysis, choice of positioning, design of integrated online and offline strategies.
Designing the enterprise's identity for traditional and digital communication solutions.
Design and development of websites, applications for smartphones (iPhone) and for social networks (Facebook).
Design of the brand, application of visual guidelines in online and offline contexts.
Display and rich media campaigns, digital PR, seeding and buzz marketing, viral marketing.
Creative concepts, conventional and unconventional solutions for B2B and B2C campaigns.
High emotional impact solutions, digital adv, gaming, viral videos, interactive applications.
Implementation of communities and social platforms, moderation of UGC, customer support services.
HTML5 Website Responsive
HTML5 Website Responsive
E-commerce web site with CMS admin sistem
Seo Specialist
Copyright © 2013 Nemesi Design

subset: commoncrawl


text:
The mission of the Calvert 22 Foundation is to support and share the contemporary culture and creativity of the new east – Eastern Europe, the Balkans, Russia and Central Asia – enriching perceptions of the region and furthering international understanding.
Calvert 22 is a not-for-profit organisation committed to dialogue and discovery, to the development of international creative networks, and to the role of learning and education as the basis for knowledge sharing and institutional exchange.
The Foundation achieves its aims through:
Exhibitions and events – Calvert 22 Space hosts an ongoing programme of exhibitions, talks and screenings, being the UK's first not-for-profit institution dedicated to the presentation of contemporary art from the new east region.
Culture – The Calvert Journal is an online magazine focused on contemporary culture from the new east, including art, film, architecture, design and avant-garde culture.
Research – The Calvert Forum is an in-house think tank centred on the role of creative industries in regional development. The Forum also operates as a digital and physical platform for discussion and learning.


text:
Within City
Within 1 mile
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Sort by
best match
most reviewed first
closest first
alphabetical order
highest rated first
"Thanks so much for taking the girls in our time of "crisis". Jenna, Krystle and the rest of the staff at Noah's has been great! You are the ..."
"The staff always remembered me and bailey. Thanks for taking care of us!"
"I agree with the other users..... all you do is wait wait wait. The high school kids who run the "hospital" could really use a class in time ..."
"Dr. Jones is awessome. She has been my vet forI'm thinking 13 to 15 years since she started in the Pet store Vet Center and I have followed ..."
"Need a vet ???- usually never write a review, but felt that it was the best I can do for all at North Laurel Animal Hospital. I have ..."
"Dr. Jason I. Orenstein practices the secret to assuring a peaceful, happy experience for his canine patients. From the moment they come through the door, dogs enter the ..."
"The staff who answer the phone are extremely rude and in person, they are the same. In general, the staff doesn't seem to like working with animals. The ..."
"The best vet ever!!! No exaggerations- I have two special needs rescue Samoyeds who need frequent check-ins for various ailments or medication, and I have never met a ..."
"Dr. Sanderson and his staff are wonderful...compassionate, gentle, friendly and competent. We've been bringing our almost-20- year-old Siamese cat to Animal Wellness Center ever since she was diagnosed ..."
"great place to take your pets in for anything from basic check ups to the most extreme situation. Every time i have gone the staff has been extremely ..."


text:
Marco V – My Trip is Out Now!
Master of Arts and veteran Marco V is back with a techy monster called "My Trip".
Supported by the sexy vocals and Marco V's signature sound it...
Read More
Holl & Rush – Morse Code is Out Now!
We're glad to have the Holl & Rush boys back on Flamingo with their electro house banger Morse Code!
Have a listen to this infectious mainstage...
Read More
Flamingo ADE 2015 is Out Now!
With Amsterdam's finest music festival only days away, Flamingo Recordings has just the right sound to get you in the mood. A housy,...
Read More
Official Music Video for Going Deeper – Taste The Night feat. Ryan Konline!
The hit-single "Taste The Night" by Going Deeper feat. Ryan Konline now gets support with the Official Music Video!
Check this one out on Yout...
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Strobe & Zakfreestyler feat. Krizzo – One Day is Out Now!
Strobe & Zakfreestyler feat. Krizzo - One Day is Out Now on Flamingo, Check this one out!
Read More
Going Deeper feat. Jacob A – The Fate Is Out Now!
Upcoming artist Going Deeper release their 2nd single on Flamingo.
This time with the support vocals by Jacob A, "The Fate" is a perfect house ...
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Mell Tierra feat. Santa Rosa – Lose Your Mind is out now!
After his successful record "Headsprung" earlier this year, Mell Tierra is back with a massive jam featuring Santa Rosa! Check this one out:
Read More
Alex Gaudino – I'm Movin' is out now!
Alex Gaudino makes his debut on Flamingo Recordings with I'm Movin'! Check this one out:
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Plastik Funk, Vanillaz & Kosta Radman – Sidekick is out now!
New track by Plastik Funk, Vanillaz & Kosta Radman - Sidekick is out now on Flamingo Recordings. Check this one out:
Read More
Housequake – GET.ON. is out now!
New track by Housequake - GET.ON. is out now on Flamingo Recordings. Check this one out:
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text:
I'm so confused on what to do.
You say that you need me.
Then why do you leave me?
It tears me apart and drops my heart.
Which direction do I go,
Do I follow my heart or not?
Should I stick with you and hope for the better?
Or let it fade like a old letter?
I'm tired of being confused even though I still love you.
You are always with me in my head, but I'm still led...
I'm led to believe that you really don't need me.
This lack of trust is killing me,
So I guess I will let it be.
I remember when you made my heart alive.
And again fooled by a mans lie.
Why can't I trust, why can't I love?
When am I going to find the truth......
Never again, I've lost my soul.
The worst part is, I failed my goal.
I wanted to find love, I really wanted to happen.
But my plans didn't work out.......
© Copyright 2017 ToLoveIsToHate. All rights reserved.
Status: Finished
Genre: Poetry
I love this
I'm sorry though .
Great job though
Whoaa... intense
Loved it though, showed a lot of emotions! I can never get tired of your work.. keep writing , Love!!
Book / Romance
Book / Romance
Book / Editorial and Opinion
Paste the link to picture in the entry below:
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text:
Top Definition
Banging a chick so ugly you have to stick her head in whale blubber to do her just so you can generate heat for fear of freezing to death, but you just cant look at that and do the deed!
The Eskimo Blubber Bump works best in cold climates when a bag isn't available!
by Cypriot Turk Buster January 17, 2012
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


text:
- Inside The Park
- Calendar
- Plan Your Visit
- Park Information
- Travel
San Diego, CA
The City of San Diego and the Balboa Park Conservancy, co-producers of this classic San Diego celebration, would like to thank our generous sponsors. We could not have welcomed 360,000 visitors to the Park over the two-day event without the support of these wonderful organizations.
We would also like to thank the entertainment groups, the Park museums and cultural organizations and the many Balboa Park and community volunteers who made this festival so special.
We're hoping to spend the first Friday and Saturday of December (December 1 and 2, 2017) with you next year to celebrate the 40th anniversary of San Diego's premiere holiday event.
Take a look at some of the highlights from Balboa Park December Nights 2016!
Balboa Park December Nights, the nation's premier holiday festival, will take place for the 39th consecutive year on Friday, December 2 from 3-11pm and Saturday, December, 3 from noon-11pm. Friends, families and the community are invited to come together for festive fun, food and attractions throughout the park, including complimentary admission to Balboa Park museums from 5-9pm. The largest free community festival in San Diego, December Nights is expected to attract more than 350,000 visitors to the park over two days to revel and enjoy the season.
As in years past, the event will offer seasonal entertainment for the whole family as well as festive holiday lighting throughout the Park – from the Plaza de Panama canopy – to the Botanical Building – to the landmark Moreton Bay Fig Tree. Delicious cuisine and holiday cheer are also all part of the long-standing San Diego celebration.
Other time-honored traditions will include:
Food: Food from around the globe at the International Christmas Festival at the House of Pacific Relations Cottages;
Be the first to know of special events and offers. Sign Up


text:
ULZ 102/7/14 : Protective Clothing
Suppy & Delivery of Protective Clothing
|Closing Date:
|1 Aug 2014 - 10:00 AM
|Quote Document:
|[click to download]
|Document request can be from Date:
|28 Jul 2014 - 08:00 AM
|Cost (Non Refundable):
|Contact Name:
|Lungi or Mark
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|035 - 473 3433 or 035 - 473 3431
|Contact Email:
|firstname.lastname@example.com / email@example.com
No information yet
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Page publish date: 28 Jul 2014 - 07:50 AM
Umlalazi Municipality SCM Unit Strives for Fair,Equitable,Transparent , Competitive and Cost-Effective Procurement
Quotes may only be submitted on the documentation that is issued. Requirements for sealing, addressing, delivering, opening and assessment of quotes are stated in the document.
The adjuducation Committee of uMlalazi Local Municipality does not bind itself to accept the lowest or any quote.


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Our Account Representatives are available Monday through Friday 8:30am EST - 6:00pm EST
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The Blodgett 1048 DOUBLE Pizza Deck Oven is a double deck unit with decks 48" wide by 37" deep, with a stainless steel build, and produces 85,000 BTU. This Pizza Deck Oven with simple design makes it easy to operate, clean, with less worry of malfunction. This Blodgett 1048 DOUBLE Pizza Deck Oven is also known as: 1048DOUBLE, Pizza Oven, Deck Oven
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The 2016 Poetry Marathon Anthology
The 2016 Poetry Marathon Anthology is now available! You can buy a copy here.
The 2016 Poetry Marathon Anthology is now available! You can buy a copy here.
The title says it all. Submissions to the 2016 Poetry Marathon Anthology are closed. I will try to reply to everyone who submitted within the next week,
Submissions for the 2016 Poetry Marathon Anthology opened this morning, the 3rd of September and will stay open till the 12th of September. No submissions will be accepted after that point.
All submissions must include two poems, no more, no less. All submissions must be made via our email address (firstname.lastname@example.com). The subject line of all emails must be Poetry Submission. Poems must be included in the body of the email.
All poems submitted must be written during the 2016 Poetry marathon. All poems should be completely edited and contain no major grammatical errors. You must indicate which hour each poem was written in. Only poets who completed the whole or half marathon will be eligible to submit. If you signed up for the whole marathon and only completed the half, submit as a half marathoner.
There is no guarantee that by submitting to the anthology your poem will be selected.
Digital copies will be made available for free to any contributor. Print copies will be available for a reasonable price and any money that is made from them will go back into the marathon.
Want to know what the 2014 Poetry Marathon Anthology was like? Pick up your copy here.
It's warmth wraps around me
a woodsy smell envelopes me
it is soft & worn
as I put my arms in its sleeves
I remember, it working
in the woodshop –
Daddy's workshirt…
soft memories hug me…
the aroma wafts towards my nose,
I think of the hands
that lovingly prepared
those hand-cut
potatoes, thick slices
piled high in the cast iron
cooked to crispy perfection
as my teeth sink in,
ahhh, yummy
grandma's fried potatoes!
boom, clatter, crash
as I sit watching the train slowly pass…
screech, rumble growl
the cars pick up speed…
clackity-clack goes the track
and I watch it go by…
the rain beats down on the windshield
wipers bashing at the chaos
trucks splattering more water
than those tiny blades can swipe
cursing the rain, the car zooms along
I'm wishing I had time
to stop and dance in the rain…
Well, I thought I'd have all my poems posted by now, however, life intruded…I will try to finish posting them this weekend…
A proud old man lives below me
He doesn't go out too much
Too fragile to even bow
Limbs cracking at seams
Into the dead of the night
I could hear his words
building an enterprise of his senses
To go out and act on his behalf
Soft like butter
Feels like felt
Saws like sin
Seas like svelte


text:
How to Plant a Cherry Tree
Cherry trees are so beautiful when they are in bloom that they are an ideal choice if you want a tree that doubles as an edible ornamental. Fruit-producing types don't have double flowers or weeping habits like ornamental cherries, but they make up for this shortcoming by producing buckets of juicy fruits. Cherry trees always bloom in spring, but in some years they fail to set fruit, even when conditions seem perfect. Perhaps they're saving their energy, because when a cherry tree does have a good year, the harvest is huge.
Sweet or Tart?
Choose from the two types of cherries: sweet and tart. Sweet cherries are for plucking right off the tree and eating fresh, but the trees often don't fruit well in climates with mild winters. Tart cherries, which are fine for cooking, are more widely adapted and often easier to grow. All cherries mature in early summer.
How to use dwarf cherries
Use a pair of dwarf cherries to anchor a strawberry bed or plant the ground beneath them with little spring-flowering bulbs. Dwarf cherries have a neat, upright growth habit that makes them easy to fit into any type of landscaping plan. If you want a more sculptural tree, a standard-size cherry may be an ideal choice.
Keep birds out
Fine netting is the surest way to discourage birds from devouring your crop. Cover the whole tree with the netting and remove it as soon as your harvest is done. Alternatively, string black cotton thread among the branches just before ripening begins. Take a spool of thread, grab the free end and toss the spool back and forth over the tree to a helper; continue until the spool is empty. Birds will hit the invisible thread and find it too much trouble to return to the tree.
Plant a dwarf cherry in a tub
Select a tub or other large container at least 20 inches (50 cm) in height and width. Fill it with a mixture of equal parts garden soil, compost, and per liter, plant your cherry and grow it on your deck or patio.
Republished from:
1,519 All-Natural All-Amazing Gardening Secretsbuy NOW$31.96
Thanks! You're on our list.
And your life's about to get more interesting.
Some people like to travel by train because it combines the slowness of a car with the cramped public exposure of an airplane.
Dennis Miller
I think my pilot was a little inexperienced. We were sitting on the runway, and he said, "OK, folks, we're gonna be taking off in a just few—whoa! Here we go."
Kevin Nealon
"I can't wait until your vacation is over." —Everyone following you on Instagram
A man knocked on my door and asked for a donation toward the local swimming pool. So I gave him a glass of water.
Comedian Greg Davies
Just found the worst page in the entire dictionary. What I saw was disgraceful, disgusting, dishonest, and disingenuous.
Client: We need you to log in to the YouTube and make all our company videos viral.
From clientsfromhell.net
My cat just walked up to the paper shredder and said, "Teach me everything you know."
"Just because you can't dance doesn't mean you shouldn't dance." —Alcohol
@yoyoha (Josh Hara)
My parents didn't want to move to Florida, but they turned 60 and that's the law.
—Jerry Seinfeld
Q: What do you call an Amish guy with his hand in a horse's mouth?
A: A mechanic.


text:
Who will win scoring title? Does Kobe or Durant really care?
Kobe Bryant said he doesn't care about winning the scoring title.
"I'm not really tripping about it," he said last week.
Kevin Durant said if he doesn't win any individual awards, it's "cool with me."
Believe them? We'll see if owning the 2012 NBA scoring crown matters to either player after the Lakers wrap up their season Thursday at Sacramento.
Durant scored 32 points in the Thunder's season-ending loss and finished the season with 1,850 points in 66 games giving him a 28.03 average. He has won the past two scoring titles, two in his first four years in the league.
''If I don't win the scoring title or MVP or whatever, it doesn't mean that I didn't have a good year by my standards,'' Durant said.
''To think back on everything I've done this season, I've gotten better. I've improved in every area I wanted to improve in. I scored a few points but I think as a defender and as a facilitator, I got better.''
Bryant has a 27.9 average and needs to score 38 points to overtake the Oklahoma City star and win his third title and first since 2006-07. Should he win, the Lakers star would be the first player over the age of 30 to win since Michael Jordan in 1997-98.
Bryant has scored at least 38 points in seven of his 58 games this season, so the feat is not impossible. It's just a matter of where his priorities lay. Should he rest, as many of the starters will be against the Kings, or go after the title?
Bryant said will make his decision to play or not Thursday at shoot around, but indicated last week he didn't want to miss any more games after sitting out eight because of a sore left shin.
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text:
Why Getting Older Means Getting Better
With age comes wisdom—or so the saying goes. According to a recent study in the Journal of Social Sciences and Medicine, however, substituting "happiness" for "wisdom" may be equally true. While growing happier and more satisfied as we move into our later years may seem counter-intuitive, evidence from the study suggests it's the case for men and women across the U.S. and around the world. Here's why…
We hit our low point at 44.
The study, led by researchers in the U.S. and U.K., incorporated data collected from men and women from 80 countries over the course of 35 years. The findings revealed that regardless of gender, nationality, or economic circumstances, human beings tend to experience wellbeing in a "u-shaped curve," with the least fulfilled years falling in the early-to-mid 40s.
Our outlook improves as we're pushing 50.
Researchers who study middle age have found similar evidence that after we bottom-out in our mid-40s, or experience that proverbial "midlife crisis," our mood improves and things start looking up. Why? One reason may be that we get smarter, at least about some things. Certain types of mental tasks may actually become easier in our 50s and 60s, as we apply our accumulated knowledge or "crystallized intelligence" to new information.
We become more goal-oriented.
In our 20s and 30s, we set the bar high for ourselves personally and professionally. If we haven't achieved those goals by our 40s, that's when we tend to plunge into the depression and dissatisfaction associated with middle age. By our 50s, we have a more realistic sense of those things that are truly important to us and will bring fulfillment, and we're able to set new goals and focus on achieving them.
We find satisfaction in our achievements.
If we spend the early decades of our adult years identifying with the Rolling Stones "(Can't Get No) Satisfaction," by the time we reach our 50s and 60s, we tend to have a change of heart. After our mid-40s reality check and our resulting sense of purpose and renewal, we're able to take stock of our lives with a clear eye and appreciate where we've come, how we got there, and what we achieved along the way. So you didn't star opposite Meryl Streep on Broadway. You did have two great kids who are becoming two impressive adults and started your own successful business. Which is more meaningful at the end of the day?
Source: huffingtonpost.com
Thanks! You're on our list.
And about to get a whole lot healthier.
Some people like to travel by train because it combines the slowness of a car with the cramped public exposure of an airplane.
Dennis Miller
I think my pilot was a little inexperienced. We were sitting on the runway, and he said, "OK, folks, we're gonna be taking off in a just few—whoa! Here we go."
Kevin Nealon
"I can't wait until your vacation is over." —Everyone following you on Instagram
A man knocked on my door and asked for a donation toward the local swimming pool. So I gave him a glass of water.
Comedian Greg Davies
Just found the worst page in the entire dictionary. What I saw was disgraceful, disgusting, dishonest, and disingenuous.
Client: We need you to log in to the YouTube and make all our company videos viral.
From clientsfromhell.net
My cat just walked up to the paper shredder and said, "Teach me everything you know."
"Just because you can't dance doesn't mean you shouldn't dance." —Alcohol
@yoyoha (Josh Hara)
My parents didn't want to move to Florida, but they turned 60 and that's the law.
—Jerry Seinfeld
Q: What do you call an Amish guy with his hand in a horse's mouth?
A: A mechanic.


text:
- Anonymous
- Estonia, Female, 31-40
- Novice Nomad
- 1 review
Friendly place, right in the centre and you pretty much get what you pay for €10 a night don't expect champagne & strawberries. I arrived after midnight and there was a person just a phone call away to come and let me in. Location is great!
Hostelworld Mobile Apps
Book on the go with the new Hostelworld mobile apps.


text:
enjoying them all, Bob. The Pink is luscious. The falls on the red
are velvet, but this one is most outstanding. Its colors just glow.
I hope it's a good grower. Congratulations.
Francelle Edwards Glendale, AZ
Zone 9
-----Original Message-----
From: firstname.lastname@example.com
[mailto:email@example.com] On
Behalf Of email@example.com
Sent: Sunday, September 23, 2007
To: email@example.com
Subject: [iris-photos] Seedling
This is seedling 23BX3. Queens Circle X
Dutchman's Dream sib.
Bob in Denver
Iris4u Iris Garden
Sexual Health
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text:
Located between the Marais Poitevin known as the Green Venice and the forest, not far from La Rochelle, our gite, very comfortable for 4 persons or 4 adults and 2 children, is located in the peaceful setting of a small south Vendée Hamlet....
This charming Paris studio apartment is located on the Left Bank in the heart of the 7th Arrondissement. The tranquil efficiency is available for short term rentals and romantic get-aways. This is the perfect location- just minutes from the Eiffel T...
Paris hotels classified by district by landmark and by price...
French language courses for Juniors and children(6 to 17 yo) and an all inclusive stay in a campus nearby Paris for Juniors from 13 to 17 which includes full board accommodation, French courses, leisure activities, visits and excursions in Paris....
We're located in Montmartre, only minutes from Sacre Coeur, one of the most popular meeting spots in Paris. Just within walking distance from our hostel you have your choice of museums, the famous weekend flea market at Clignancourt flea market, Sacre Coeur and the artistic district of la Butte Montmartre - and then when you are done exploring you can feel good about chilling out in a café to watch the world go by, just like the Parisians.
We have free luggage storage for those arriving and departing, as well as free breakfast, free maps, free linen and blankets and no curfew! The rooms are cleaned daily and our kitchen has been recently refurbished to provide everything you need to prepare your meals with friends.
Our friendly staff will be happy to give you tips and ideas for inexpensive and fun activities or to reserve major attractions the likes of Disney, Moulin Rouge and more. We strive to make our common room fun and comfortable and the perfect place to meet our other guests. We're travellers too so we know that many times it is not about where you are as much as who you meet. Our formula is tough to beat because we have the beautiful, fantastic and magical Paris and a super friendly atmosphere.
We're close to the post office, Metro, supermarkets, world-famous Paris bakeries, Laundromats, restaurants and clubs. There's private bicycle parking available.
In case we're full, we suggest that you try the other HIPHOPhostels located nearby. These include Regent Hostel, Square Caulaincourt, Le Village, Vintage Hostel, Woodstock Hostel, and Plug-Inn Hostel. Other hostels and budget hotels include Oops! and Young & Happy Hostel in the Latin Quarter; The 3 Ducks and Aloha Hostel over near the Eiffel Tower and Absolute Paris which is located on Canal St. Martin. Each of us in the HIPHOPHOSTELS family (code for we all have the same owners). All HIPHOPHOSTELS are consistent, in that we have friendly and knowledgeable staff, we are all located in convenient and authentic areas of Paris and we all offer great value for the money. We're not cookie-cutter in that we are all the same. Like any family we all have our own personalities but we are sure a HIPHOPHOSTEL has something for every type of budget traveller.
Please note that we do not allow guests under the age of 18 unless accompanied by an adult, with written authorisation from your parents before booking. Thanks for your understanding.
If you get twisted around, give us a call!
From Gare Du Nord:
Take the metro line 4 to the station 'Marcadet-Poissonnier', change to the line12 and get off at the next stop 'Jules Joffrin', then folllow directions as above.
From Charles de Gaulle Airport:
Take the train RER B to Paris station 'Gare du Nord', then take the metro line 4 to the station 'Marcadet-Poissonnier', change to the line 12 and get off at the next stop, 'Jules Joffrin'. Then follow directions as above.
From Orly Airport:
Take the train RER B to Paris station 'Gare du Nord', then take the metro line 4 to the station 'Marcadet-Poissonnier', change to the line 12 and get off at the next stop 'Jules Joffrin'. Then follow directions as above.
From Gare De L'Est:
Take the metro line 4 to the station 'Marcadet-Poissonnier', change to the line 12 and get off at the next stop 'Jules Joffrin'. Then follow directions as above.
From Beauvais Airport:
Take the shuttle to Paris 'Porte Maillot', then take the metro line 1 to the station 'Concorde', change to line 12 and get off at the station 'Jules Joffrin. Then follow directions as above.
|Map Legend
|Le Montclair Montmartre
62, Rue Ramey, Paris, France


text:
Holker Hall is the home of the Cavendish family who welcome visitors of all ages to one of the best-loved stately homes in Britain. Magnificently situated only a short distance from Grange-over-Sands and the expanse of Morecambe Bay. Holker Hall is set in exceptionally beautiful countryside with gardens that merge into Parkland framed by the Lakeland Hills.
2017 Opening Dates
Cafe, Food Hall and Gift Shop open Fridays, Saturdays and Sundays
from 3rd February to 24th March, 10.30am - 4pm.
NEW Snowdrop Weekends - The Gardens will also be open on 17th - 19th and 24th - 26th February.
Main Season - Hall & Gardens, Cafe, Food Hall and Gift Shop
Saturday 25th March to Sunday 29th October, Wednesday to Sunday (& Bank Holiday Mondays) 10.30am - 5pm (Hall 11am - 4pm)


text:
Virtual Tour
Spacious Victorian home on corner lot in village. Offering excellent walkability. Hardwood floors and gorgeous wood trim and railing details. Plenty of storage. 3 baths make those family mornings less hectic. Cozy stove in the family/den for the fall and winter. Welcoming front porch to enjoy the spring and summer. Owner indicates that electric is approx. $60/month and heating is $80/month winter
† Excluded Feature
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135 Rowley Street, Gouverneur, NY, 13642 is a Single Family Home for sale at $126,900 with 2,112 sqft and a lot size of 64 X 150. 135 Rowley Street has 4 bedrooms, 3.0 baths, and was built in 1890. The property's zip code is 13642 which is in Gouverneur, NY
Based on 20.00 % down and a 4.13 % financing rate
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all is by my side (2013) download Lqqp free file
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Is our relentless quest for economic growth killing the planet? Climate scientists have seen the data – and they are coming to some incendiary conclusions.Some evenings, when we force her to go to bed, she will pretend to go to sleep and then get back up and continue to do homework for another hour.3/17/2013 · Alvin benefits no less from his wife's domestic reign. Kelly keeps a list of his clothing sizes in her iPhone and, devoted to his cuteness, surprises him ...11/23/2013 · Lawrence R. Jacobs is a professor of political science at the Humphrey School of Public Affairs at the University of Minnesota and the author, with Theda ...10/11/2013 · Around the Web. The Truth About the Corset Diet | Women's Health Magazine. Corset diet: Extreme weight loss trend sees women constricting their ...7/4/2013 · "Show all mail to supv" — supervisor — "for copying prior to going out on the street," read the card. It included Mr. Pickering's name ...6/14/2013 · We know sitting at a desk all day is bad for us. But not everyone has a company gym membership or a workweek that allows for morning and afternoon …David Simon: 'There are now two Americas. My country is a horror show'Distinction Gallery, located in Escondido, California features contemporary and cutting edge art and sculptures by emerging and internationally acclaimed artists ...2/11/2013 · Domestic violence, the propensity of some to accept it, its causes and its aftermath is everyone's business.
all is by my side (2013)
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Philip Soltysiak
Phil Soltysiak just spent 3 weeks windsurfing in Tarifa, Spain. Though it was a cold winter in Europe, Phil still scored quite a few nice sessions. This clip is one afternoon at Playa Chika, in the city of Tarifa. The beach is the first place to get windy when easterly Levante winds arrive.


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Gasoline prices in Rhode Island and Massachusetts fell 2 cents this week, AAA Northeast said Monday. more
By Matt Bower
WARWICK – Passenger traffic at T.F. Green Airport increased 1.6 percent, to 337,336, in August over a year ago, according to the R.I. Airport Corp. With that gain, total passenger traffic at the state's only commercial airport has increased 2.7 … more
CEO (or equivalent): Jason Case, CEO and president 2015 Revenue: $29,063,732 2013 Revenue: $8,670,468 Revenue growth: 235% It's a fact of life in the Northeast: It may not be next week, it may not be next month, … more
By Taryn Plumb | Contributing Writer | 9/22/16
ARCHITECTURE, CONSTRUCTION, ENGINEERING As with windshield wipers, you never seem to notice or appreciate a bridge as much as when it quits on you. Twenty-two percent of Rhode Island's 1,162 bridges are … more
BY Mary Lhowe | Contributing Writer | 9/22/16
Updated 1:18 p.m. There's going to be a new way to get to Block Island. The R.I. Division of Public Utilities and Carriers on Thursday approved an application filed by Rhode Island Fast Ferry Inc. more
By Eli Sherman
Reason Foundation published its 22nd annual Highway Report on Thursday ranking all 50 states in terms of overall highway performance and cost effectiveness. The news isn't good for Rhode Island, as its 47th ranking lands it only three spots higher than last place Alaska. more
By Matt Bower
Companies that remove snow, supply electricity to commercial customers and remove toxins from drinking water were among the 30 local enterprises that were recognized Wednesday night at Providence Business News' fifth Fastest-Growing & Innovative Companies event, held at the Crowne Plaza Providence-Warwick. more
Gasoline prices are unchanged from a week ago in Rhode Island and Massachusetts, according to AAA Northeast. more
By PBN Staff
(Updated, 4:37 p.m.) Passenger traffic at T.F. Green Airport increased 1.6 percent to 337,336 in August over a year ago, according to the R.I. Airport Corp. With that gain, total passenger traffic at the state's only commercial airport has increased 2.7 percent through the first eight months of the year to 2,428,374. more
By PBN Staff
NEW BEDFORD – State transportation officials gave the go-ahead on Sept. 12 to using an unspent, $5 million federal earmark from 2005 for long-needed structural work at the city's aging State Pier, a state legislator said. "I've gotten … more


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Holiday childcare(9 Posts)
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Papal Mass in Washington will be in Spanish
When Pope Francis celebrates a canonization Mass at for Junípero Serra, he will do so in a language Serra would recognize: Spanish.
When Pope Francis celebrates a canonization Mass at for Junípero Serra, he will do so in a language Serra would recognize: Spanish.
Pope Francis held a "virtual town hall" with Catholics in Chicago, Los Angeles and McAllen, Texas, in advance of his Sept. 22-27 visit to the United States.
Ever since Pope Francis' visit to Cuba was announced, Cuban church officials have billed him as the "missionary of mercy."
And it's an important mission, some Cubans say, so that the country and its people -- living in and outside of Cuba -- can move forward. The pope's message of mercy is exactly what Cuba needs, some say.
"Cuba needs mercy because Cubans have been divided even inside Cuba, and Cubans have been divided even outside Cuba," said Eduardo Azcarate, born in Havana but who now lives in Falls Church, Va.
The U.S. trade embargo against Cuba turns 55 in October, and its effects are clear in the dilapidated buildings, scant food supply of Cuban stores and infrastructure around the island.
But what's not easy to see is the spiritual cost. Trinitarian Fr. Juan Molina, director of the U.S. bishops' Office for the Church in Latin America, said that spiritual cost has been great.
X may mark the spot at the National Geographic Museum's exhibit "Indiana Jones and the Adventure of Archaeology," which features 100 carefully crafted film props alongside real archaeological finds.
Catholic advocates say that agreement across a broad spectrum of Catholic groups in support of the Iran nuclear deal demonstrates a "seamless garment" approach to difficult public policy issues.
A federal appeals court ruled that there is no religious rights conflict with a process for nonprofit religious organizations to get around a mandate to provide contraceptive coverage in employee health insurance.
Auxiliary Bishop Eusebio Elizondo of Seattle reported on conditions for displaced members of Myanmar's Kachin ethnic minority in a Catholic-run camp near the Myanmar-China border.
Montgomery, Alabama-based St. Jude Parish became the first stopover in the NAACP's "Journey for Justice" march, which started Aug. 1 in Selma, Alabama.
Getting the food service at St. Xavier University to change from plastic to biodegradable cups doesn't seem like it's a big deal.
But for Guadalupe Avila, a senior at the Sisters of Mercy-sponsored school in Chicago, it showed that she and her fellow members of Students for Social Justice can make a difference when it comes to the earth's environmental future.
Now she's ready to tackle Congress.


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"""Golffirmations is an uplifting mix of meditations, poems, limericks, inspiring stories, golf prayers, and instructional mantras from the masters, along with occasional instructional tips or secrets. It is an anthology of exuberance and a celebration of the game, its courage, its toughness, and its humor. We love the game. And yet, who among us hasnt known the pain? The divot the size of Delaware. The two-footer that dies halfway to the hole. Until now, weve had no place to seek solace when double bogeys trouble our dreams. But take heart, for here is the golfers book of faith, hope, and hilarity. Golffirmations arrives with healing balm for golf wounds stories, swing-tips, inspiration, and humor to help us keep swinging."""
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Feelings and Emotions
The Amsterdam Symposium
Edited by Antony S. R. Manstead Nico H. Frijda Agneta H. Fischer
Format: Hardback
Normal Price: $205.00
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Feelings and Emotions by Antony S. R. Manstead
Book DescriptionEmotions are central to human behavior and experience. Yet scientific theory and research ignored emotions during most of the twentieth century. This situation changed dramatically during the last 30 years of that century, which witnessed an upsurge of interest in emotions in a number of disciplines. This book arises from the 24 keynote papers presented at a symposium held in June 2001 that had the same title as this volume. The aim of that meeting was to review the state of research on emotions from a multidisciplinary perspective. Each chapter is authored by an acknowledged authority in the field. Together they provide an overview of what is being studied and thought about emotions, in disciplines ranging from neurophysiology and experimental psychology to sociology and philosophy.
Buy Feelings and Emotions book by Antony S. R. Manstead from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780521816526
(228mm x 152mm x 27mm)
Pages: 504
Imprint: Cambridge University Press
Publisher: Cambridge University Press
Publish Date: 5-Apr-2004
Country of Publication: United Kingdom
Other Editions...
Books By Author Antony S. R. Manstead
Landscapes of Emotion, Paperback (November 2006)
This book studies the cultural constructions of emotions, examining how different cultures shape ideas.
Intersubjective Communication and Emotion in Early Ontogeny, Paperback (November 2006)
A comprehensive 1999 volume examining concept of intersubjectivity in emotion and communication of the very young.
Emotion in Social Context, Paperback (December 2004)
Within psychology, emotion is often treated as something private and personal. In contrast, this book tries to understand emotion from the 'outside,' by examining the everyday social settings in which it operates. It provides a review of theory and research on these topics from a social psychological perspective.
Feelings and Emotions, Paperback (April 2004)» View all books by Antony S. R. Manstead
This book provides an overview of the status of emotion theory.
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text:
|Reviews for The Slender Games
| Jacks fanfic chapter 2 . 8/10/2013
Are you not going to update?
| Alice Kingsleighs chapter 2 . 5/16/2013
Holy sh*it what a twisted sick game! I LOVE YOU SENECA ! YOU ROCK!
Okey I may look like a freaking crazy, but no I just enjoyed this slenderman idea it's GREAT, because I love horror heck yea, GAAH why on hiatus, can't wait for you to update
| Hoprocker chapter 2 . 3/25/2013
Oh dear...rated M? I don't believe I've ever read an M-rated story. I hope I can handle it. XD
Pepper is cool. OMG Slenderman, please come kill Felton, I will love you forever if you do. Well, not really. But still. If I were in these Games, I think I would just gather all of the tributes and be like "okay everyone, here's what's going down, here's what we gotta do." Unfortunately, they don't even know what's coming...dude, the Gamemakers should totally implement the soundtrack. It makes Slender ten times scarier. Sorry, I'm getting off topic.
OH MY GOD SERIOUSLY FREAKING OUT, GET OUT OF THERE MITSUKO...okay. She's okay.
OH MY GOD OKAY NOW I CAN FREAK OUT WTF...let me go cry in a corner for a second...okay, anyways, I like how you did it! Even if it's really scary. TT_TT (I'm going to be typing this emoticon a lot aren't I) but everyone always wonders what Slenderman does. Does he kill you, does he rape you, is he just asking for his $20 back...but I like how you kept it so mysterious and then had her body just appear there. Holy cow!
Looking forward to the next chapter. Remind me to not read this at night. Oh man, and you're keeping the creepy bathroom hallways right? I think that's the scariest place of all. I always come to it first and refuse to go in. DX
| Hoprocker chapter 1 . 3/25/2013
Ahhh! I'm sorry, I expressed interest in this story, then I forgot about it. Luckily I remembered it XD Now I'm here to read/review! I can't help but be reminded of playing this traumatizing game. My friends recorded my reaction and basically it was just begging them to take the computer and play it for me, then when I died, I screamed my head off. Now it's on FB so everyone can hear me wailing like a dying puppy. My heart goes out to each and every one of these tributes.
Nnnuuuuhhh TT_TT This kind of reminds me of a warped version of Running Man too, this variety show where sometimes they'll have to collect pieces of something, but at the same time, they're being hunted by someone or another team. And the more pieces you have, the bigger a target you are. GAH! DON'T LOOK OR IT TAKES YOU TToTT
/deep breathe/ Anyways, I'm glad this story launched right into the games. Gotta love that. :) From first impressions, I liked Sylvia the most. Onto the next chapter!
| Guest chapter 2 . 2/24/2013
Poor girl from district 7... she should have listened to her partner more. And poor Heinz. The careers were sadly right about that cabin being a hotspot for tributes.
| SeekerDraconis chapter 2 . 2/22/2013
Aww, District 7 was the first team to die. :( I think I would be rooting for Pepper, the albino girl.
| hungergameshgfan chapter 2 . 2/21/2013
Great new chapter
| Pika And Olive's Adventures chapter 2 . 2/18/2013
That was awesome! I'm really excited to read more. You could always add the different settings in the slender games, but that would kinda defeat the purpose huh? Not sure what I meant by that, but whatever. I like the description of the text and can't wait for it to go along further.
| squidlings chapter 2 . 2/18/2013
| SeekerDraconis chapter 1 . 2/16/2013
Oh. My. God. SLENDER!
| Pika And Olive's Adventures chapter 1 . 2/16/2013
Oooooo! I'm so excited! Sounds great so far! :D
| Guest chapter 1 . 2/15/2013
Cool Story idea! Update Soon!
| angelchild chapter 1 . 2/14/2013
Just wonderful. Great job with introducing all the main players, as well as a very original idea for the games. Can't wait to see more!
| ImmyRose chapter 1 . 2/14/2013
I agree; this arena/ Quarter Quell idea is definitely not something that I've seen before in any story, so I'll give you points for originality. Also, it means that these Games will be very different from a typical one, because there's always the possibility that the non-Careers might try and group together to defeat Slender while the more arrogant Careers might continue to try and kill everybody as they usually do. I like the fact that you're writing this from more than one or two POVs since it means that we won't be able to predict who (if anyone) wins this year's Games as easily, depending on if you foreshadow events right xD
I did spot a spelling mistake in the D3 section, where you spelled the word "physical" like "psychical", so I thought you might want to change that unless I'm missing something here and it's supposed to be psychical :P But that's the only error I spotted since you have good grammar and spelling (which is a nice change from illiterate fan fiction that is barely readable).
- Immy
| Lord Shade chapter 1 . 2/14/2013
Well, I didn't see that one coming...and I'm sure neither did the tributes. I'm really intrigued by your characters and your QQ twist. I can't wait to see where this goes.
Although, I must admit I'm a little disappointed you won't be going into the political history of this universe. The politics was something I found fascinating in the HG games. Not to rake away from your story, I just liked the political intrigue. But i suppose you're going a different direction.
I look forward to reading more and keep up the good work.


text:
Find a copy online
Links to this item
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|Electronic reference sources
Early works
Early works to 1800
|Material Type:
|Document, Updating database, Internet resource
|Document Type:
|Internet Resource, Computer File, Continually Updated Resource
|All Authors / Contributors:
|Adam Matthew Digital (Firm)
|OCLC Number:
|Title from title screen (viewed Dec. 12, 2007).
|1 online resource
|Mode of access: World Wide Web.
Provides an extensive collection of manuscript materials for the study of medieval travel writing. The core is a collection of medieval manuscripts dating from the 13th to the 16th centuries. The main focus is accounts of journeys to the Holy Land, India and China. The manuscripts are from the British Library; Bodleian Library; Bibliothèque nationale de France; Cambridge University Library; Trinity College, Cambridge; Universitätsbibliothek Heidelberg; Staatsbibliothek zu Berlin, Österreichische Nationalbibliothek; Stiftsbibliothek St. Gallen; the Beinecke Library at Yale University and about 15 other Libraries and Archives.
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Related Subjects:(12)
- Voyages and travels -- Early works to 1800.
- Europeans -- Travel -- Sources.
- Travelers' writings, European -- Sources.
- Travel writing -- Europe -- History.
- Literature, Medieval.
- Voyage -- Art d'écrire -- Europe -- Histoire -- Sources.
- Littérature médiévale -- Sources.
- Europeans -- Travel.
- Travel writing.
- Travelers' writings, European.
- Voyages and travels.
- Europe.
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by josephhafner updated 2015-09-22


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Stefan Guggisberg" <stefan.guggisb...@gmail.com>
|Re: importing XML file performance
|Fri, 13 Apr 2007 14:12:03 GMT
hi alan, sorry for the late response, it took me a while to figure out what's causing the bad performance you experienced. i performed a couple of tests on my machine (2ghz macbook). i used the test data you provided me (17mb document view-format xml file consisting of 40 nodes, 291 properties whereof 15 are of type BINARY). i used SimpleDbPersistenceManager on a local mysql 5.0 instance. here are the results of the Wokspace#importXML tests: - ~180 seconds using jdk 1.4 (256mb heap) - ~400 seconds using jdk 1.5 (256mb heap) profiling revealed that about 85% of cpu time was spent in GC... in order to further isolate the issue i measured the time it takes to just parse the the xml file by passing a DefaultHandler (consisting of noop's only) to the sax parser. the results were somewhat baffling ;-) just parsing took ~250 seconds using jdk 1.4, i.e. considerably longer than when performing a full import!?! seems like a very busy GC causes these strange results... further guessing and analysis showed that the binary properties in document view serialization are responsible for the busy GC and bad performance. the sax parser seems to be very inefficient in handling large attribute values. the good news is that a system view import of the same data is a *lot* faster since property values are represented as element content rather than attribute values: ~20 seconds (system view) vs ~180 seconds (document view). for your specific use case (importing large binary properties) i'd recommend using system view format. cheers stefan On 4/11/07, Alan R <email@example.com> wrote: > > Hi. I'm using Jackrabbit 1.2.2 (JNDIPersistenceManager on MySQL, external > blobs), and I'm finding the importXML() call very, very slow. I've tried > calling it both on the session and on the workspace and don't notice much > difference. Where the export takes seconds, the import takes minutes. My > average file size will be just under 20 MB (consisting of on the order of 20 > blobs and 60 nodes per file), and there could be tens or even hundreds of > these to import in the case of a system restoration from backup. I can > afford 20 minutes to restore the system, but not 20 hours. > > Currently I've tried it with a single 17MB file, and workspace.importXML() > takes 8 and a half minutes. It was the same for session.importXML(). > > Are there any performance enhancements underway? This seems like a really > important feature to speed up, because any time I need to migrate data, > recover from a disk failure or change fundamental jackrabbit configuration, > I will need to import exported data, including blobs. > > Is there something flawed in my backup/restoration strategy? > > Thanks. > -Alan > > > quipere wrote: > > > > Saving it on the workspace would take about half of the time, if I am > > right. But I will than be stuck with the risk of making my own rollback > > functions. Because I am persisting more actions than only the xmlimport on > > one session.save(). > > Is the node.remove also loading all the childnodes in memory? Because when > > I remove the mainNode of the imported xml. It consumes an even amount of > > memory as the import function? > > > > > > Jukka Zitting-3 wrote: > >> > >> On 10/24/06, quipere <email@example.com> wrote: > >>> Does everybody have the same performance results while importing this > >>> XML? > >> > >> Yes. The imported content is stored in the transient state of the > >> session, which is kept fully in memory. Additionally, the Jackrabbit > >> ItemState objects used to represent nodes and properties in memory are > >> heavier than the DOM equivalents, so large XML files will use lots of > >> memory when imported. > >> > > > > -- > View this message in context: http://www.nabble.com/importing-XML-file-performance-tf2493911.html#a9936830 > Sent from the Jackrabbit - Users mailing list archive at Nabble.com. > >
|View raw message


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10 Trade Fairs in Philadelphia from March 2017
Exhibition calendar with currently 10 trade fairs from March 2017 in Philadelphia. The most common types of trade fairs in Philadelphia are Industry, Subcontracting and Machine Construction.In addition to the current trade fairs, Sights & Attractions in Philadelphia can also be visited.
PHS Philiadelphia Flower Show
Fair for flowers
professional visitors and general public
Trade fair on chromatography
professional visitors only
Loews Philadelphia Hotel Philadelphia, USA
Plastics trade fair
professional visitors only
Quality Expo
Trade fair for quality assurance
professional visitors only
Design & Manufacturing
Industrial trade fair
professional visitors only
The Franchise Expo
Trade Fair for franchising and business
professional visitors only
Philadelphia Gift Show
Exhibition for gifts, handcrafted goods and decoration
professional visitors only
Greater Philadelphia Expo Center Philadelphia, USA
International Conference and Exposition for Filtration
professional visitors only
ASHA Convention
Conference and exhibition for education and training
professional visitors only
Philadelphia Home Show
Trade fair for construciton and housing
publicly accessible
Schedule of trade fairs with current 10 trade fairs in Philadelphia. Of course also other interesting trade fairs can take place in Philadelphia, which are not yet known to us. If you know trade fairs in Philadelphia that are not listed, you can transmit them to us via announce new trade fair Our team will update them in a timely manner to promote these fairs as well. Trade fairs with expired dates or trade fair dates yet unknown to us can be found at the end of the above list, labelled with the button "report new date of event".


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Madrush is an easy to play racing game that you will not be able to put down. Awesome graphics. Challenging gameplay. Game Center integration. Rock and roll soundtrack. 3 different game types with 10 levels each. Multiplayer mode coming soon. What else could you want?
Control is simple- tilt your iPhone or iPad left/right to control Noop (your racing rabbit with attitude). As Noop moves, he eats various items which powers him to move faster and faster. Avoid the obstacles. Go for the powerups. Don't hit the power downs. Get the picture?
Graphics for Madrush are great. Our only complaint is the performance of loading some of the screens. Many times switching screens takes a few seconds and you aren't sure if the app is doing anything. The gameplay is very smooth. Once you are playing there are no performance issues. The periodic performance issues are only during switching screens.
As you grow in skills points you can purchase additional skills which help move through the higher levels. There is an in-app purchase ($0.99) for different racing suits. One purchase buy all the suites. Once you purchase the suits you can decide which suit (and which special power) are more suitable for the opponent you are currently battling. Purchasing the suits is not required but it helps.
The opponents are hard to beat. They seem to accelerate faster and avoid the obstacles better than I can. They are not impossible but it's certainly a challenge. It's the right balance. I can't wait for the multiplayer mode so I can play against mere mortals.
You can find out more at the Mad Rush website.
Check out the trailer:
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text: NBC's Today Hosts Michael Vick In-Studio, Confuses Him For Jerrod JohnsonTimothy Burke7/17/12 10:20amFiled to: Media MeltdownsMichael VickToday ShowNbcPhiladelphia EaglesNflMatt LauerVideoNewsSports8EditPromoteShare to KinjaToggle Conversation toolsGo to permalink NBC's Matt Lauer brought Eagles QB Michael Vick into the Today studio this morning for a conversation full of personal growth and life lessons and redemption. To call Lauer's questions softballs is an insult to softballs; his prompts were more like those weird-ass softballs they use in Chicago. Advertisement More importantly, though, when demonstrating Vick's football abilities, NBC used B-roll footage of a player who is not Michael Vick. It's not Vince Young, either, but Jerrod Johnson who spent parts of 2011 with the Eagles and is now with the Steelers. It's unclear how such a mistake could be made, given the quarterback in the clip isn't wearing Vick's #7 and is, uh, right-handed. But hey, NBC, we all make mistakes.h/t to WilliamReply8 repliesLeave a reply


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Need an MMR Titer in Diablo, CA? Simply order online 24/7 and get a fast, affordable MMR Titer at a lab near you (Find More Locations):
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- Connect
- About
- Research
- Publications
- email@example.com
- (859) 218-3858
- SB-332, Sanders Brown Center on Aging 0230
In our laboratory, we seek to elucidate the mechanisms underlying the actions of genetic polymorphisms that modulate the risk of disease, especially Alzheimer's disease (AD). Our goal is to translate these findings into novel approaches to prevent or treat human disease. We are primarily focused on AD genetics because genetic risk factors drive the majority of AD risk. Also, since genetic variants modulate AD risk, then by definition, drugs that act similarly will also modulate AD risk. Hence, we interpret the pathways identified by genetics as validated drug targets.
Our experimental approach begins by noting that high throughput genome wide association studies have identified a series of single nucleotide polymorphisms (SNP)s that are robustly associated with AD risk. Hence our goal is to perform molecular genetic studies to identify the mechanisms of action underlying these SNPs. The primary actions of these SNPs, or their co-inherited proxy SNPs, are to (i) alter amino acid sequence, (ii) alter gene expression or (iii) alter mRNA splicing. For each of the AD-associated SNPs, we are working through the process of determining the molecular impact of the SNP. For example, a CD33 SNP has been associated with AD risk. We found that this SNP acts through a co-inherited proxy SNP to modulate the splicing efficiency of the second exon in CD33. The allele that protects from AD risk reduces the inclusion of exon 2. The CD33 isoform lacking exon 2 is predicted to produce a non-functional CD33. Hence, our findings suggest that reducing CD33 function protects from AD risk. We are currently pursuing this hypothesis at multiple levels, including the study of CD33 inhibitors.
Overall, our work is facilitated by our association with the Sanders-Brown Center on Aging and its Alzheimer's Disease Center (ADC). Our ADC has been critical in providing hundreds of DNA samples from well-characterized AD and control individuals, which are necessary for genotyping polymorphisms, as well as autopsy-derived CSF and brain samples, which has allowed us to quantify the levels of the gene products and genetic variant proteins of interest in a rapid and human-disease relevant fashion. We have similar projects that focus upon other AD-related polymorphisms, as well as pilot studies to evaluate the actions of polymorphisms that modulate the risk of multiple sclerosis, migraine, and ALS.
In summary, the overall goal of our laboratory is to use human genetics to identify molecular mechanisms that modulate the risk of human disease, especially AD. These studies contribute to the fight against AD by identifying individuals at risk, identifying possible novel therapies, and tailoring therapy to responsive individuals.
2014-2018 NIH R01AG045775. "Translating CD33 genetic mechanism into a novel Alzheimers therapeutic"
2014-2016 Bright Focus. "Genomic Editing to Elucidate CD33 Function".
Malik M, Chiles J 3rd, Xi HS, Medway C, Simpson J, Potluri S, Howard D, Liang Y, Paumi CM, Mukherjee S, Crane P, Younkin S, Fardo DW, Estus S. Genetics of CD33 in Alzheimer's Disease and Acute Myeloid Leukemia Hum Mol Genet. (2015) [Epub ahead of print]
Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G. Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease. Neuron. 84:63-77 (2014) PMC4199382
Parikh I, Medway C, Younkin S, Fardo DW, Estus S. An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform. Mol Neurodegener. 9(1):32 (2014). PMC4150683
Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Kofler JK, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA. Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Kamboh IL, Montine TJ, Partch AB, Richmire KR, Monsell SE, Alzheimer' Disease Genetic Consortium, Schellenberg GD, Fardo DW. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 127: 825-843 (2014). PMC4113197
Parikh I, Fardo DW, Estus S. Genetics of PICALM Expression and Alzheimer's Disease. PLoS One. 9(3):e91242 (2014). PMC3949918
Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Mol Neurodegener. 10: 1750-1326-9-2 (2014). PMC3897976
Vasquez JB, Fardo, DW and Estus, S. ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status. Neurosci. Lett. 556: 58-62 (2013) PMC3863933
Malik M, Simpson JF, Parikh I, Wilfred BR, Fardo DW, Nelson PT, and Estus S. CD33 Alzheimer's risk-altering polymorphism, CD33 expression and exon 2 splicing. J. Neurosci. 33: 13320-05 (2013). PMC3742922
Nelson PT, Pious NM, Jicha GA, Wilcock DM, Fardo DW, Estus S, Rebeck GW. APOE-E2 and APOE-E4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature. J Neuropathol Exp Neurol. 72:708-15 (2013). PMID: 23771217
Ling, I-F, Bhongsatiern J, Simpson, JL, Fardo, DW and Estus S. Genetics of clusterin isoform expression and Alzheimer's disease risk. PLoS ONE 7(4):e33923. (2012) PMC3323613
- Chester, D.S.;DeWall, C.N.;Derefinko, K.J.;Estus, S.;Lynam, D.R.;Peters, J.R.;Jiang, Y. "Looking for reward in all the wrong places: dopamine receptor gene polymorphisms indirectly affect aggression through sensation-seeking." Social neuroscience 11, 5 (2016): 487-94. [PubMed Link] |
- Gan, W.Q.;Estus, S.;Smith, J.H. "Association Between Overall and Mentholated Cigarette Smoking With Headache in a Nationally Representative Sample." Headache 56, 3 (2016): 511-8. [PubMed Link] | [ Full text ]
- De Rossi, P.;Buggia-Prévot, V.;Clayton, B.L.;Vasquez, J.B.;Sanford, C.;Andrew, R.J.;Lesnick, R.;Botté, A.;Deyts, C.;Salem, S.;Rao, E.;Rice, R.C.;Parent, A.;Kar, S.;Popko, B.;Pytel, P.;Estus, S.;Thinakaran, G. "Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts." Molecular neurodegeneration 11, 1 (2016): 59. [PubMed Link] |
- Kang, S.S.;Kurti, A.;Wojtas, A.;Baker, K.E.;Liu, C.C.;Kanekiyo, T.;Deming, Y.;Cruchaga, C.;Estus, S.;Bu, G.;Fryer, J.D. "Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes." Human molecular genetics 25, 16 (2016): 3467-3475. [PubMed Link] | [ Full text ]
- Malik, M.;Parikh, I.;Vasquez, J.B.;Smith, C.;Tai, L.;Bu, G.;LaDu, M.J.;Fardo, D.W.;Rebeck, G.W.;Estus, S. "Genetics ignite focus on microglial inflammation in Alzheimer's disease." Molecular neurodegeneration 10, (2015): 52. [PubMed Link] |
- Malik, M.;Chiles J, 3rd;Xi, H.S.;Medway, C.;Simpson, J.;Potluri, S.;Howard, D.;Liang, Y.;Paumi, C.M.;Mukherjee, S.;Crane, P.;Younkin, S.;Fardo, D.W.;Estus, S. "Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia." Human molecular genetics 24, 12 (2015): 3557-70. [PubMed Link] | [ Full text ]
- Chester, D.S.;DeWall, C.N.;Derefinko, K.J.;Estus, S.;Peters, J.R.;Lynam, D.R.;Jiang, Y. "Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect." Behavioural brain research 283, (2015): 97-101. [PubMed Link] | [ Full text ]
- Downer, B.;Estus, S.;Katsumata, Y.;Fardo, D.W. "Longitudinal trajectories of cholesterol from midlife through late life according to apolipoprotein E allele status." International journal of environmental research and public health 11, 10 (2014): 10663-93. [PubMed Link] | [ Full text ]
- Liu, C.C.;Tsai, C.W.;Deak, F.;Rogers, J.;Penuliar, M.;Sung, Y.M.;Maher, J.N.;Fu, Y.;Li, X.;Xu, H.;Estus, S.;Hoe, H.S.;Fryer, J.D.;Kanekiyo, T.;Bu, G. "Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease." Neuron 84, 1 (2014): 63-77. [PubMed Link] | [ Full text ]
- Gold, B.T.;Zhu, Z.;Brown, C.A.;Andersen, A.H.;LaDu, M.J.;Tai, L.;Jicha, G.A.;Kryscio, R.J.;Estus, S.;Nelson, P.T.;Scheff, S.W.;Abner, E.;Schmitt, F.A.;Van Eldik, L.J.;Smith, C.D. "White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults." Neurobiology of aging 35, 10 (2014): 2263-71. [PubMed Link] | [ Full text ]
- Parikh, I.;Fardo, D.W.;Estus, S. "Genetics of PICALM expression and Alzheimer's disease." PloS one 9, 3 (2014): e91242. [PubMed Link] | [ Full text ]
- Tai, L.M.;Mehra, S.;Shete, V.;Estus, S.;Rebeck, G.W.;Bu, G.;LaDu, M.J. "Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk." Molecular neurodegeneration 9, (2014): 2. [PubMed Link] |
- Parikh, I.;Medway, C.;Younkin, S.;Fardo, D.W.;Estus, S. "An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform." Molecular neurodegeneration 9, (2014): 32. [PubMed Link] |
- Nelson, P.T.;Estus, S.;Abner, E.L.;Parikh, I.;Malik, M.;Neltner, J.H.;Ighodaro, E.;Wang, W.X.;Wilfred, B.R.;Wang, L.S.;Kukull, W.A.;Nandakumar, K.;Farman, M.L.;Poon, W.W.;Corrada, M.M.;Kawas, C.H.;Cribbs, D.H.;Bennett, D.A.;Schneider, J.A.;Larson, E.B.;Crane, P.K.;Valladares, O.;Schmitt, F.A.;Kryscio, R.J.;Jicha, G.A.;Smith, C.D.;Scheff, S.W.;Sonnen, J.A.;Haines, J.L.;Pericak-Vance, M.A.;Mayeux, R.;Farrer, L.A.;Van Eldik, L.J.;Horbinski, C.;Green, R.C.;Gearing, M.;Poon, L.W.;Kramer, P.L.;Woltjer, R.L.;Montine, T.J.;Partch, A.B.;Rajic, A.J.;Richmire, K.;Monsell, S.E.;Alzheimer' Disease Genetic, C.;Schellenberg, G.D.;Fardo, D.W. "ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology." Acta neuropathologica 127, 6 (2014): 825-43. [PubMed Link] | [ Full text ]
- Vasquez, J.B.;Fardo, D.W.;Estus, S. "ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status." Neuroscience letters 556, (2013): 58-62. [PubMed Link] | [ Full text ]
- Nelson, P.T.;Pious, N.M.;Jicha, G.A.;Wilcock, D.M.;Fardo, D.W.;Estus, S.;Rebeck, G.W. "APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature." Journal of neuropathology and experimental neurology 72, 7 (2013): 708-15. [PubMed Link] | [ Full text ]
- Tai, L.M.;Bilousova, T.;Jungbauer, L.;Roeske, S.K.;Youmans, K.L.;Yu, C.;Poon, W.W.;Cornwell, L.B.;Miller, C.A.;Vinters, H.V.;Van Eldik, L.J.;Fardo, D.W.;Estus, S.;Bu, G.;Gylys, K.H.;LaDu, M.J. "Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples." The Journal of biological chemistry 288, 8 (2013): 5914-26. [PubMed Link] | [ Full text ]
- Malik, M.;Simpson, J.F.;Parikh, I.;Wilfred, B.R.;Fardo, D.W.;Nelson, P.T.;Estus, S. "CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing." The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 33 (2013): 13320-5. [PubMed Link] | [ Full text ]
- Holler, C.J.;Webb, R.L.;Laux, A.L.;Beckett, T.L.;Niedowicz, D.M.;Ahmed, R.R.;Liu, Y.;Simmons, C.R.;Dowling, A.L.;Spinelli, A.;Khurgel, M.;Estus, S.;Head, E.;Hersh, L.B.;Murphy, M.P. "BACE2 expression increases in human neurodegenerative disease." The American journal of pathology 180, 1 (2012): 337-50. [PubMed Link] | [ Full text ]
- Youmans, K.L.;Tai, L.M.;Nwabuisi-Heath, E.;Jungbauer, L.;Kanekiyo, T.;Gan, M.;Kim, J.;Eimer, W.A.;Estus, S.;Rebeck, G.W.;Weeber, E.J.;Bu, G.;Yu, C.;LaDu, M.J. "APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease." The Journal of biological chemistry 287, 50 (2012): 41774-86. [PubMed Link] | [ Full text ]
- Ling, I.F.;Bhongsatiern, J.;Simpson, J.F.;Fardo, D.W.;Estus, S. "Genetics of clusterin isoform expression and Alzheimer's disease risk." PloS one 7, 4 (2012): e33923. [PubMed Link] | [ Full text ]
- Smith, J.D.;Moylan, J.S.;Hardin, B.J.;Chambers, M.A.;Estus, S.;Telling, G.C.;Reid, M.B. "Prion protein expression and functional importance in skeletal muscle." Antioxidants & redox signaling 15, 9 (2011): 2465-75. [PubMed Link] | [ Full text ]
- Simmons, C.R.;Zou, F.;Younkin, S.G.;Estus, S. "Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease." Molecular neurodegeneration 6, (2011): 33. [PubMed Link] |
- Burchett, M.E.;Ling, I.F.;Estus, S. "FBN1 isoform expression varies in a tissue and development-specific fashion." Biochemical and biophysical research communications 411, 2 (2011): 323-8. [PubMed Link] | [ Full text ]
- Simmons, C.R.;Zou, F.;Younkin, S.G.;Estus, S. "Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk." Molecular neurodegeneration 6, (2011): 62. [PubMed Link] |
- Dieter, L.S.;Estus, S. "Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism." Molecular neurodegeneration 5, (2010): 34. [PubMed Link] |
- Ling, I.F.;Gopalraj, R.K.;Simpson, J.F.;Estus, S. "Expression and regulation of a low-density lipoprotein receptor exon 12 splice variant." Journal of neurochemistry 115, 3 (2010): 614-24. [PubMed Link] | [ Full text ]
- Ling, I.F.;Estus, S. "Role of SFRS13A in low-density lipoprotein receptor splicing." Human mutation 31, 6 (2010): 702-9. [PubMed Link] | [ Full text ]
- Grear, K.E.;Ling, I.F.;Simpson, J.F.;Furman, J.L.;Simmons, C.R.;Peterson, S.L.;Schmitt, F.A.;Markesbery, W.R.;Liu, Q.;Crook, J.E.;Younkin, S.G.;Bu, G.;Estus, S. "Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain." Molecular neurodegeneration 4, (2009): 46. [PubMed Link] |
- Liu, Q.;Zhang, J.;Tran, H.;Verbeek, M.M.;Reiss, K.;Estus, S.;Bu, G. "LRP1 shedding in human brain: roles of ADAM10 and ADAM17." Molecular neurodegeneration 4, (2009): 17. [PubMed Link] |
- Zhu, H.;Taylor, J.W.;Bennett, D.A.;Younkin, S.G.;Estus, S. "Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease." Neurobiology of aging 29, 5 (2008): 793-4. [PubMed Link] | [ Full text ]
- Zou, F.;Gopalraj, R.K.;Lok, J.;Zhu, H.;Ling, I.F.;Simpson, J.F.;Tucker, H.M.;Kelly, J.F.;Younkin, S.G.;Dickson, D.W.;Petersen, R.C.;Graff-Radford, N.R.;Bennett, D.A.;Crook, J.E.;Younkin, S.G.;Estus, S. "Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease." Human molecular genetics 17, 7 (2008): 929-35. [PubMed Link] | [ Full text ]
- Zhu, H.;Tucker, H.M.;Grear, K.E.;Simpson, J.F.;Manning, A.K.;Cupples, L.A.;Estus, S. "A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol." Human molecular genetics 16, 14 (2007): 1765-72. [PubMed Link] | [ Full text ]
- Tangpong, J.;Cole, M.P.;Sultana, R.;Estus, S.;Vore, M.;St Clair, W.;Ratanachaiyavong, S.;St Clair, D.K.;Butterfield, D.A. "Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain." Journal of neurochemistry 100, 1 (2007): 191-201. [PubMed Link] | [ Full text ]
- Rebeck, G.W.;LaDu, M.J.;Estus, S.;Bu, G.;Weeber, E.J. "The generation and function of soluble apoE receptors in the CNS." Molecular neurodegeneration 1, (2006): 15. [PubMed Link] |
- Tangpong, J.;Cole, M.P.;Sultana, R.;Joshi, G.;Estus, S.;Vore, M.;St Clair, W.;Ratanachaiyavong, S.;St Clair, D.K.;Butterfield, D.A. "Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity." Neurobiology of disease 23, 1 (2006): 127-39. [PubMed Link] | [ Full text ]
- Joshi, G.;Sultana, R.;Tangpong, J.;Cole, M.P.;St Clair, D.K.;Vore, M.;Estus, S.;Butterfield, D.A. "Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: insight into chemobrain." Free radical research 39, 11 (2005): 1147-54. [PubMed Link] | [ Full text ]
- Gopalraj, R.K.;Zhu, H.;Kelly, J.F.;Mendiondo, M.;Pulliam, J.F.;Bennett, D.A.;Estus, S. "Genetic association of low density lipoprotein receptor and Alzheimer's disease." Neurobiology of aging 26, 1 (2005): 1-7. [PubMed Link] | [ Full text ]
- Ertekin-Taner, N.;Ronald, J.;Feuk, L.;Prince, J.;Tucker, M.;Younkin, L.;Hella, M.;Jain, S.;Hackett, A.;Scanlin, L.;Kelly, J.;Kihiko-Ehman, M.;Neltner, M.;Hersh, L.;Kindy, M.;Markesbery, W.;Hutton, M.;Andrade, M.;Petersen, R.C.;Graff-Radford, N.;Estus, S.;Brookes, A.J.;Younkin, S.G. "Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene." Human molecular genetics 14, 3 (2005): 447-60. [PubMed Link] | [ Full text ]
- Tucker, H.M.;Simpson, J.;Kihiko-Ehmann, M.;Younkin, L.H.;McGillis, J.P.;Younkin, S.G.;Degen, J.L.;Estus, S. "Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice." Neuroscience letters 368, 3 (2004): 285-9. [PubMed Link] | [ Full text ]
- McCollum, A.T.;Estus, S. "NGF acts via p75 low-affinity neurotrophin receptor and calpain inhibition to reduce UV neurotoxicity." Journal of neuroscience research 77, 4 (2004): 552-64. [PubMed Link] | [ Full text ]
- Bruckner, S.R.;Perry, G.;Estus, S. "4-hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis." Journal of neurochemistry 85, 4 (2003): 999-1005. [PubMed Link] | [ Full text ]
- Whitaker, C.;Eckman, C.;Almeida, C.;Feinstein, D.;Atwood, C.;Eckman, E.;Crutcher, K.;Hersh, L.;Leissring, M.;LaVoie, M.;Ertekin-Taner, N.;Shapiro, P.;Takahashi, R.;Yamin, R.;Mansourian, S.;Estus, S.;Lesné, S.;Turner, T.;Farris, W.;Stroebel, G. "Live discussion: Amyloid-beta degradation: the forgotten half of Alzheimer's disease. 12 September 2002." Journal of Alzheimer's disease : JAD 5, 6 (2003): 491-7. [PubMed Link] | [ Full text ]
- Bu, J.;Bruckner, S.R.;Sengoku, T.;Geddes, J.W.;Estus, S. "Glutamate regulates caveolin expression in rat hippocampal neurons." Journal of neuroscience research 72, 2 (2003): 185-90. [PubMed Link] | [ Full text ]
- McCollum, A.T.;Nasr, P.;Estus, S. "Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death." Journal of neurochemistry 82, 5 (2002): 1208-20. [PubMed Link] | [ Full text ]
- Tucker, H.M.;Kihiko-Ehmann, M.;Estus, S. "Urokinase-type plasminogen activator inhibits amyloid-beta neurotoxicity and fibrillogenesis via plasminogen." Journal of neuroscience research 70, 2 (2002): 249-55. [PubMed Link] | [ Full text ]
- Estus, S.;Borchelt, D.;Kindy, M.S.;Vassar, R. "Abeta deposition is essential to AD neuropathology." Journal of Alzheimer's disease : JAD 4, 3 (2002): 133-8. [PubMed Link] | [ Full text ]
- Bruckner, S.R.;Estus, S. "JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons." Journal of neuroscience research 70, 5 (2002): 665-70. [PubMed Link] | [ Full text ]
- Bruckner, S.R.;Tammariello, S.P.;Kuan, C.Y.;Flavell, R.A.;Rakic, P.;Estus, S. "JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons." Journal of neurochemistry 78, 2 (2001): 298-303. [PubMed Link] | [ Full text ]
- Dhillon, H.S.;Dong, G.X.;Yurek, D.M.;Estus, S.;Rangnekar, V.M.;Dendle, P.;Prasad, R.M. "Regional expression of Par-4 mRNA and protein after fluid percussion brain injury in the rat." Experimental neurology 170, 1 (2001): 140-8. [PubMed Link] | [ Full text ]
- Wu, H.J.;Venkataraman, C.;Estus, S.;Dong, C.;Davis, R.J.;Flavell, R.A.;Bondada, S. "Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation." Journal of immunology (Baltimore, Md. : 1950) 167, 3 (2001): 1263-73. [PubMed Link] | [ Full text ]
- Tucker, H.M.;Kihiko-Ehmann, M.;Wright, S.;Rydel, R.E.;Estus, S. "Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition." Journal of neurochemistry 75, 5 (2000): 2172-7. [PubMed Link] | [ Full text ]
- Tucker, H.M.;Kihiko, M.;Caldwell, J.N.;Wright, S.;Kawarabayashi, T.;Price, D.;Walker, D.;Scheff, S.;McGillis, J.P.;Rydel, R.E.;Estus, S. "The plasmin system is induced by and degrades amyloid-beta aggregates." The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 11 (2000): 3937-46. [PubMed Link] | [ Full text ]
- Tammariello, S.P.;Quinn, M.T.;Estus, S. "NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 1 (2000): RC53. [PubMed Link] | [ Full text ]
- Nair, P.;Tammariello, S.P.;Estus, S. "Ceramide selectively inhibits apoptosis-associated events in NGF-deprived sympathetic neurons." Cell death and differentiation 7, 2 (2000): 207-14. [PubMed Link] | [ Full text ]
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text: Elon Musk: "Humans Need To Be A Multiplanet Species"Robbie Gonzalez4/16/15 7:00pm6831EditPromoteGo to permalink Bad Astronomy's Phil Plait recently visited the SpaceX construction factory. His visit also included a chat with CEO Elon Musk. This should excite you. Plait is a consummate nerd, and Elon Musk is Elon Musk. Bring them together and you're bound to get good things (the quote up top, for instance).


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The Deal
- $12 for one ticket to see The Three Musketeers (up to a $19.90 value)
- When: select dates on February 14–March 1
- Where: UpStage Theatre
- Seating: general admission
- Door time: one hour before showtime
- Ticket values include all fees.
The Three Musketeers
Based on the classic adventure tale by Alexandre Dumas, The Three Musketeers tells the story of the gallant d'Artagnan and the titular trio of swashbuckling heroes. Heading to Paris in search of adventure, the protagonist meets each of the musketeers in turn, hotheadedly challenging them to duels before all four find themselves enmeshed in a conspiracy involving the sinister Cardinal Richelieu and Countess de Winter. Ken Ludgwig's script leavens the danger with zippy humor and the addition of Sabine, d'Artagnan's tomboyish sister who also gets entangled in the musketeer's adventures. Winning praise from the Guardian for "distilling [the story's] energy and strengthening its timeless appeal," the script delights audiences with courtly intrigue, dazzling sword fights, and a never-explained dearth of muskets.
UpStage Theatre
Theater should be accessible for all. That's the belief espoused by UpStage Theatre, a non-profit, volunteer-run company that welcomes everyone from experienced attendees to newcomers who still expect Godot to show up. Each season places an emphasis on works that are as professional in their staging as they are family-friendly in their content. To that end, UpStage produces children's plays—which have included Alice in Wonderland and You're a Good Man, Charlie Brown—alongside all-ages classics such as On Golden Pond and Blithe Spirit.
1703 Heights Blvd.
Houston, TX 77008
+17138387191Get Directions


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Langford Large Wood Mirror
by Uttermost
At A Glance:
The Langford Large Wood Mirror features a wide frame with antique hickory undertones and a burnished distressing. This mirror is a great way to give any room in your home a rustic feel. Can be hung vertical or horizontal.
- Overall Size: 80.5" h x 50.5" w x 2" d
- Designed by Carolyn Kinder
- Generous 10" wide frame
- Antiqued hickory undertones
- Burnished distressing
- Mirror has a generous 1 1/4" bevel
- May be hung either horizontal or vertical
Materials & Measurements
Wood, Glass and plywood
- Overall Size: 80.5" h x 50.5" w x 2" d
- Glass Size: 60" h x 30" w x 0.187" d
- Box Size: 55.125" l x 85.125" w x 8.5" t
About The Manufacturer
For nearly half a century, the family owned Uttermost has produced premium quality home accessories and decor at an affordable price. Uttermost was founded on the idea of an inter-connected product cycle. From the initial designer to the end consumer, Uttermost understands that everyone is connected and deserves respect and appreciation. From accent furniture, to wall art and home decor, Uttermost offers a diverse designs while maintaining the highest levels of quality and craftsmanship.
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REVIEW SNAPSHOT®by PowerReviews
Reviewed by 2 customers
Comments about Uttermost Langford Large Wood Mirror:
We love this mirror as well as everyone that comes over. it is really a statement piece. My only complaint is that is difficult to hang. We have metal studs in our house. And you need to do a lot of measuring to get it level b/c there are two little triangle hooks in each corner. I wish it was a wire but it says on the back to not use a wire.
- Was this a gift?:
- No
Comments about Uttermost Langford Large Wood Mirror:
The mirror is beautiful and exactly as pictured. Everyone loves it and asked where we purchased. My only complaint was the hanging...it is very heavy and unfortunately we have metal studs in our wall so it was very difficult to get secure especially with the triangle shaped clips on each corner the nails hangs on. you have to do some perfect measuring to make sure it is level and you need two people at least to hang.
Service and delivery comments:
I couldn't have asked for better costumer service or faster delivery.
- Was this a gift?:
- No