text:
U.S. Rep. Gary Ackerman (D-Bayside) and a Flushing home for elderly Armenians are calling on Congress to pass a resolution that would condemn a Turkish massacre of Armenians during the early 1900s as a genocide after a congressional committee approved the measure.
Last week, the House Foreign Affairs Committee voted 23-22 in favor of calling the mass killings of Armenians in Turkey between 1915 and 1918 a genocide. President Barack Obama's administration is against the measure, arguing the vote could offend Turkey, an ally to the United States.
Ackerman, a senior member of the committee, said he voted in favor of the resolution, referring to two Armenian women — Charlotte Kechejian, 98, and Onorik Eminian, 97 — from Flushing's Armenian Home at 137-31 45th Ave., who traveled to Washington, D.C., for the vote.
"They're here for justice," Ackerman said prior to the vote. "How long can they wait? Shall we tell them once again to come back next year? History has to be righted."
The resolution will now go before the full House for a vote.
Turkey's foreign minister said last week the vote would hurt ties between the Obama administration and slow down reconciliation efforts between Turkey and Armenia.
Nearly 1 million Armenians living in the Turkish Ottoman Empire were slaughtered during the massacre. The genocide is believed to have begun April 24, 1915, after Ottoman authorities arrested 250 Armenian intellectuals in Constantinople. An estimated 972,000 Armenians in the empire were killed during a period of three years.
The slaughter has been recognized as genocide by more than 20 nations, but the Turkish government still does not use that word to describe the incident. Some parts of that nation's society have questioned the state's version of events.
Jenny Akopyan, associate director of the Armenian Home in Flushing, said she traveled with the two survivors to Washington for the vote on the resolution.
"We were apprehensive about making a trip with 98-year-olds, but they did well," she said. "They were resolute. Politics are in play here. People have said it's not the time because Turkey is America's ally, but it's never a good time. We are just asking for justice, for them to admit it happened. We're not saying the present government or population of Turkey is guilty."
St. Sarkis Armenian Apostolic Church, a large house of worship in Douglaston, could not be reached for comment.
Reach reporter Nathan Duke by e-mail at firstname.lastname@example.com or by phone at 718-260-4566.
©2010 Community News Group
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Release of Information Server 11.5 Governance Rollup 3 Community Blog
KunjavihariK Tags: dataquality datagovernance bigdata 1,314 Views
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Machine Learning Algorithm != Learning Machine
JeanFrancoisPuget Tags: bigdata machine_learning datascience analytics 9 Comments 39,802 Views
How easy it is to build a learning machine? Shouldn't one just hire some Machine Learning PhDs and have them run their algorithms? Well, this is most probably a good idea, but it won't be enough. I'll try to explain why in this...
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Fueling your Insights into the natural resource of our generation - the Big Data
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|Message view
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|Bogdan DINU <flex.programm...@gmail.com>
|Re: Flex 5 UIComponent - Behavior Pattern
|Mon, 23 Jan 2012 17:31:12 GMT
Hi Doug, I'm so much pleased that you are the devils advocate. The point of view you have presented is somehow a trap - I'll explain this in the end of my reply. I must agree with your point of view : creating is slow, destroying is even slower. But then, why we are on the mailing list? To find solutions. I've read all the thread about cloning components. First answer that comes into my mind is to clone stuff - I know it's stupid, but it's 1st solution. I really don't think is about nice architecture, but only about the flexibility. I usually speak to people that Flex suffered two paradigm changes, which I'm sure. Never took into account how many objects were created (because each developer creates something that you cannot control as an architect). Spark is faster then Halo, just because a small change in terms of thinking :) isn't it ? And Halo, compared to 1.5 is totally something else, isn't it (again) ? Where is the trap in being devils advocate : in that rule that says "prefer composition over inheritance". Well, I cannot argue against this one, because I haven't formulated it. Probably they were right. Probably the were not. I think there is 50-50 chance that someone is right. Unless the gang of four have changed their minds... On Mon, Jan 23, 2012 at 6:43 PM, Doug McCune <email@example.com> wrote: > Just one counter-thought to play devils advocate a bit. One thing you have > to consider is performance, especially on something like UIComponent that > drives every little thing in your app. And in general, creating lots of new > Objects is slow (and disposing of them can also be slow due to the GC). > Overall I think most people see the benefit of a highly-composited > UIComponent that lets you define only the necessary functionality and lets > you swap out each little bit of behavior with another. However, if you end > up with all UIComponents creating 100 new objects each time a UIComponent > is initialized, you may be trading a nice architecture for performance. The > big consideration, I think anyway, when deciding on what should be moved to > composition, is what pieces would we want to turn off by default? Focus is > a good example. If there are a lot of cases where we want focus off (even > to the point where that would be default and you'd have to turn it on > explicitly), then I love the idea of stripping 99% of the focus code out of > UIComponent and using something like a FocusBehavior. But if it's going to > be on by default, and used in most cases, then all we've done is introduced > the creation of a new Object into all UIComponents. > -- http://www.badu.ro
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Naxos travel guide
An insider's guide to Náxos, featuring the island's best hotels, restaurants, bars, things to do, attractions, and how to travel there and around. By Marc Dubin, Telegraph Travel's Náxos expert.
Why go?
The largest and loftiest (at 999m/3,247ft elevation) of the Cyclades archipelago, rugged Náxos is one of the few Greek islands besides Crete that could feed itself – you see flocks of sheep, goats and cattle everywhere, along with all manner of market gardens. The local small potatoes are renowned, commanding a price premium, as do a range of island cheeses. All of this, of course, finds its way onto the menus of the better local restaurants.
For casual visitors, there's enough else on offer to keep them busy for a week or so. The main town, specifically its hilly old quarter known as the Kástro, was the seat of the Venetian Duchy of Náxos, who ruled most of the Cyclades from this fortress after 1204.
The steep lanes of Kástro and its downhill continuation Boúrgos provide many an atmospheric wander, while out in the countryside are the tower-mansions of the Venetians and their descendants.
The biggest draw is Náxos's entire southwest-facing coast which, from the resort of Ágios Prokópios down to Agiassós near the island's southerly cape, essentially forms one great long beach, separated by little headlands and backed by a sometimes bumpy, discontinuous road. Get a good map for all rural safaris (Terrain no. 311, 'Naxos', 1:40,000, sold locally, is fine).
When to go
The Cyclades are most enjoyable in late spring – when the landscape is still green, the sea has warmed up to feasible swimming temperatures, but the crowds have yet to descend – and early autumn, when the summer hordes have departed and the sea is at its warmest. During both spring and autumn you can expect attractive prices for accommodation compared to summer.
But take note – not too late in autumn; after the third week in September many facilities close down, storms do hit and ferry links get sparse. There are also swarms of flies to contend with through much of September and October, as well as wasps and hornets from late August onwards.
Where to go
Hóra's labyrinthine kástro comprises medieval Venetian mansions, arcades, an idiosyncratic Catholic cathedral and a museum full of Cycladic figurines. Monumental interest out in the countryside includes a tastefully reconstructed ancient Demeter temple at Gyroúla, the mysterious reclining koúroi of Mélanes and Apóllonas and the frescoed Panagía Drosianí church, perhaps the oldest in Greece. Alternatively, follow the marked walking trails of the Trageá upland, or skinny-dip at secluded sandy coves at Kouroúpia in the far south.
Know before you go
British Embassy, Athens (0030 210 7272 600; gov.uk)
The Greek National Tourist Office is at 4 Great Portland Street, London W1W 8QJ (020 7495 9300; visitgreece.gr)
Ambulance 166; fire brigade 199; forest fires 191; police 100
Corfu travel guide
Crete travel guide
Santorini travel guide
Mykonos travel guide
Rhodes travel guide
Skiathos travel guide
Hydra travel guide
Patmos travel guide
Paros travel guide
Follow Telegraph Travel on Twitter


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Q. I am having trouble differentiating between mild thalassemia and iron-deficiency anemia. I am not sure why the red cell distribution width would be lower in thalassemia than IDA. Could you please explain this and list other ways to tell them apart?
A. As iron-deficiency anemia progresses, and the patient's serum iron drops lower and lower, each successive wave of new red cells gets smaller and smaller. So there are some kind of small cells, and some really small cells (as you can see in the image of iron-deficiency anemia above). The red cell distribution width (RDW) is high in iron deficiency anemia because there is a wide variation in red cell size. In mild thalassemia (alpha or beta), the red cells are strangely all the same size; there is virtually no variation. So the RDW is low. This difference in RDW is helpful when you're trying to differentiate IDA and thalassemia; if you have a microcytic, hypochromic anemia, the next thing you'd do is look at the RDW (or just look at the blood smear). If the RDW is low (the cells are mostly the same size), then it's probably thalassemia. If the RDW is high (the cells vary a lot in size), then it's probably iron deficiency anemia.
Another thing to do is look at the RBC. In IDA, the RBC is low (there isn't enough iron around, so the bone marrow makes fewer cells). In mild thalassemia, however, the RBC tends to be normal or even elevated. The reasons for this are unclear.
To definitively diagnose IDA, you need to do iron studies; to definitively diagnose thalassemia, you need to do hemoglobin electrophoresis. But you can get a pretty good idea by looking at the things discussed above.
23 Responses to How can you differentiate between iron-deficiency anemia and thalassemia?
MZaheen says:
Hello guys..
I got a simple calculation based just on CBC (Complete Blood Count)
DF = (MCV)2 x RDW – CV / Hb. x 100
Where- DF= Discriminent Function
(MCV, RDW, Haemoglobin are CBC based values)
Thus if DF value 70 Suspect for IDA
medshamsstudent says:
mariam says:
sufia says:
To separate thalassemia trait and IDA
1.Hb in TT is not less than 10g/dl but in IDA it is less upto 3g/dl.
2.RBC is more than 5million but in IDA it is less.
3.RDW is less than 17% in TT but in IDA it is more than 17%.
matthew says:
not forgetting the mentzer index as well — ratio of MCV and RBC – if more than 13 then its likely IDA. if less than 13 its suggestive of thal.
admin says:
Yes – good point! As you suggest in your comment, this test is not a definitive test (it's pretty specific but not all that sensitive).
Govindarajan says:
how can we differentiate target cell is due to liver disease or thalassemia?
Kristine says:
You'd have to look at the whole smear, the CBC (specifically, the MCV, RBC and RDW), and the patient's clinical status.
In uncomplicated liver disease (in which there is no iron-deficiency anemia due to bleeding, and no folate deficiency), the anemia is macrocytic, and there may be acanthocytes.
More often, though, there are complications in patients with liver disease: bleeding (leading to iron deficiency and a microcytic anemia) or nutritional abnormalities like folate deficiency (leading to a megaloblastic anemia). The anemia may even be a mixture of all of these features!
Mild thalassemia is microcytic, with a normal or elevated RBC and very mild anisocytosis. Severe thalassemia is also microytic, but the RBC is low and there is a ton of anisocytosis.
So: there are a lot of different features to be aware of. You may need to do look at the patient's other labs (liver function tests, etc) and/or do hemoglobin electrophoresis to figure things out.
Hope that helps.
rawda ruth sarrail says:
dear sir/mam;
thank you for the very informative haematology topic…as a Biomedical Scientist…with this additional reinforcement of info as knowledge application it will help me more validate correct clinical lab results for final analysis and lab diagnosis therefore exact prescription and patient`s medication…:::
kanmani says:
Thanks a LOT!!!!!!!!!!
Dr Ganesh says:
To differentiate anemia and Thalassemia-
1. You get mark anisopoikilocytosis in anemia and
2. The Mentzer index which is defined as mean corpuscular volume per red cell count. An index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency.
dr. Poonam ATAL Khambra says:
reason for the RBC count to be normal or elevated is because defect lies at globin chain formation level but no nutritional deficiency otherwise .so process of formation of red cells remains normal or slightly elevated to compensate for early disposal of RBCs.and ps definately helps to differentiate between the two and indices also.
z says:
very good!
wathik says:
thank you
Sahan says:
Ehsan says:
Thank you so much.
Sepehr says:
Very helpful , Thanks every1
Ahmed says:
helped me a lot; thank u so much.
mosi says:
RBC=5.15 HB=13.7 Hct=40.8 MCV=79.3 MCH=26.6
can you help me? iron-deficiency anemia or
Kristine says:
Probably thalassemia, given the low MCV and normal hemoglobin – but you'd need to do iron studies to be sure 🙂
[…] the way, the place that the RDW is most useful (in my humble opinion) is in differentiating between iron-deficiency anemia (IDA) and mild to moderate thalassemia. In IDA, as we just talked about, the RDW is high. In mild-moderate thalassemia, the RDW is not […]
geeta lallmahomed says:
Thank you very much for your help….it makes things at the lab
dr shaheen says:
thanks every one very informative discussion
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TRD Aurion of Australia vs WRX STI 1/4 mile.
A guy at work kept going on at me to race him. He has a new WRX STI that he paid $75,000 AUS for. He has spent $1600 ona cat back stainless steel Exhaust system. All I have done to the TRD is after market mufflers and K&N filter. Total cost $850. Results speak for themselves.......Yes I know he could have got his car up the 1/4 mile quicker but a win is a win. I have more plans for my car with more Boost ( Std is only 7.5psi ) and an Intercooler. I left the traction control on for all runs. 2nd run I had the traction control kick in and lost me heaps of time and 3rd run not much better. My 1st time at the drags so I was happy with result. I had 60 litres of fuel on board and tyre pressures at the front too high. Could have dropped a couple of tenths...................Next time !
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The Canon VIXIA HF G30 HD Camcorder is a professional-quality camcorder from Canon that features a Canon 20X HD Video Lens, Dynamic SuperRange Optical Image Stabilization, an HD CMOS Pro Image Sensor, and a DIGIC DV 4 Image Processor. The VIXIA HF G30 also offers the highest-quality recordings with 1080/60p recording and images captured at 60fps. The 3.5-inch OLED Touch Panel Display gives the VIXIA HF G30 easy and quick controls while the tiltable electronic viewfinder and joystick streamline critical focus adjustment.
Canon 20X HD Video Lens (35mm equivalent: 26.8mm - 576mm) with Eight-Blade Circular Aperture and Manual Focus Ring
The VIXIA HF G30 comes equipped with a Canon 20X HD Video Lens featuring aspherical lens technology to high resolution and low chromatic aberration. This lens features an 8-blade circular aperture, reducing the "starburst" effect commonly found in camcorders with non-circular apertures. That being said, the lens delivers beautifully circular, blurred backgrounds that lend an authentic feel to your videos. You'll also get a manual focus ring that gives you absolutely precise control over your focusing to get the results you want. The manual focus ring can be easily set to control zoom as well.
1080/60p Recording in MP4 and Native 24p Progressive Mode
The Canon VIXIA HF G30 delivers the highest quality recording with either MP4 or AVCHD files. You'll capture images at 1080/60p and a rate of 60 frames per second, meaning diagonal noise is pretty much eliminated and even you'll capture your fast-moving subjects crisply. The VIXIA HF G30 also features a maximum bit rate of 28Mbps for AVCHD recording. All of this equals beautiful detail in your videos with faithful renderings of edges and enhanced color and tonal gradation so that you can fully take advantage of Full HD recording.
The VIXIA HF G30 has a Native 24p Progressive Mode that allows you to capture and record 24 frames per second instead of the standard 60i, which offers a more traditional cinematic quality to your videos. A must for any serious filmmaker!
2.91 Megapixel HD CMOS Pro Image Sensor
You'll love the HF G30's professional-level 2.91-Megapixel Full HD CMOS Pro Image Sensor. Your pixels are significantly larger and more sensitive than other consumer camcorders so that you get a wide dynamic range and plenty of quality, even in low-light shooting situations.
DIGIC DV 4 Image Processor
The VIXIA HF G30 incorporates the latest and most advanced Canon HD Image Processor, the DIGIC DV 4 Image Processor, which is a significant upgrade on several fronts. The DIGIC DV 4 Image Processor helps enable impressive low-light shooting for brighter, noise-free images even in dark scenes. Dramatically increased processing power lets you record in both easy-to-share MP4 and AVCHD formats simultaneously.
Built-In Wi-Fi Technology
The Canon VIXIA HF G30 features built-in dual-band (5GHz / 2.4GHz) Wi-Fi technology so you can easily share your HD videos - transfer files to FTP servers for backup, share videos over the internet with Canon iMage Gateway, or connect with compatible networks, wireless hotspots and iOS® mobile devices using the free Canon Movie Uploader app.
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See your HD videos vividly and clearly with the VIXIA HF G30's 3.5-inch Organic Light-Emitting Diode (OLED) panel. With 1,230,000 dots of resolution, you'll be able to see your video playback clearly to make sure you have the perfect footage. The OLED also offers a touch screen that enables more fluid control of certain functions, such as Touch and Track, Touch Focus, and Touch Exposure.
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The VIXIA HF G30 features a 0.24-inch, 1,560,000-dot color electronic viewfinder with approximately 100% field of view coverage for detailed, accurate composition judgment. You can tilt the viewfinder up to 45 degrees from its normal resting position fore more shooting freedom. There's also a handy joystick for adjusting settings so you don't have to stop looking through the viewfinder. And, because it is positioned where your thumb naturally rests while holding the camera, you can shoot and adjust easily - even with one hand!
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Dual Recording in MP4 and AVCHD
Dual Recording and built-in transcoding help ensure that you'll have the right format available for your needs. With the powerful DIGIC DV 4 Image Processor, the VIXIA HF G30 camcorder can simultaneously record video in AVCHD format to one SD card,and MP4 format to the other SD card. The widely used MP4 format provides quick, conversion-free playback on tablets and smartphones and lets you upload videos directly to social networking sites for easy sharing with friends and family. AVCHD is perfect for watching videos on an HDTV or archiving them to Blu-ray discs. The camcorder also has a built-in transcoding function that converts AVCHD files to MP4s, or from MP4 to MP4 across memory media, making them easy to upload to the Web or save to an SD card.
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Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study
DOI: 10.1186/ar4600
© Tansley et al.; licensee BioMed Central Ltd. 2014
Received: 15 December 2013
Accepted: 24 June 2014
Published: 2 July 2014
The aim of this study was to define the frequency and associated clinical phenotype of anti-MDA5 autoantibodies in a large UK based, predominantly Caucasian, cohort of patients with juvenile dermatomyositis (JDM).
Serum samples and clinical data were obtained from 285 patients with JDM recruited to the UK Juvenile Dermatomyositis Cohort and Biomarker Study. The presence of anti-MDA5 antibodies was determined by immunoprecipitation and confirmed by ELISA using recombinant MDA5 protein. Results were compared with matched clinical data, muscle biopsies (scored by an experienced paediatric neuropathologist) and chest imaging (reviewed by an experienced paediatric radiologist).
Anti-MDA5 antibodies were identified in 7.4% of JDM patients and were associated with a distinct clinical phenotype including skin ulceration (P = 0.03) oral ulceration (P = 0.01), arthritis (P <0.01) and milder muscle disease both clinically (as determined by Childhood Myositis Assessment Score (P = 0.03)) and histologically (as determined by a lower JDM muscle biopsy score (P <0.01)) than patients who did not have anti-MDA5 antibodies. A greater proportion of children with anti-MDA5 autoantibodies achieved disease inactivity at two years post-diagnosis according to PRINTO criteria (P = 0.02). A total of 4 out of 21 children with anti-MDA5 had interstitial lung disease; none had rapidly progressive interstitial lung disease.
Anti-MDA5 antibodies can be identified in a small but significant proportion of patients with JDM and identify a distinctive clinical sub-group. Screening for anti-MDA5 autoantibodies at diagnosis would be useful to guide further investigation for lung disease, inform on prognosis and potentially confirm the diagnosis, as subtle biopsy changes could otherwise be missed.
Autoantibodies can be detected in approximately 60% of children with juvenile dermatomyositis (JDM)[1]. Anti-MDA5 was initially identified in adult Japanese patients with clinically amyopathic myositis and interstitial lung disease (ILD), a phenotype more commonly seen in East-Asia[1, 2]. Studies based in East-Asia have identified anti-MDA5 (anti-Melanoma differentiation associated gene 5) autoantibodies in 19 to 35% of adult dermatomyositis (DM) patients[2, 3], where it is associated with clinically amyopathic myositis (81%), rapidly progressive ILD (74%) and a poor prognosis[4, 5]. Anti-MDA5 has been identified at a lower frequency in adult Caucasians[6–8], where patients appear to have little myositis and an increased risk of ILD, but not rapidly progressive ILD. Unlike in East-Asian patients, in predominantly Caucasian adult populations a characteristic cutaneous phenotype has been described, which includes skin ulceration and painful palmar papules[2, 6, 8]. Patients can present with inflammatory arthritis, and similarities to the anti-synthetase syndrome have been described[8].
The phenotype of children with anti-MDA5 has yet to be clearly established. A small Japanese study identified anti-MDA5 in 38% of JDM patients, all of whom had ILD, and three patients with very high titres of anti-MDA5 had rapidly progressive ILD[9]. A further study of 35 Japanese JDM patients demonstrated a significant association between the presence of anti-MDA5 and the development of rapidly progressive ILD[10]. Although data on pulmonary involvement in JDM are limited, reported rates of ILD in UK and USA patients with JDM are far lower than in adult DM[11]. The incidence in Japanese JDM populations, however, has been reported to approach 50%[12]. This may reflect genetic and environmental differences or differences in autoantibody prevalence (and therefore associated complications) between these populations. Here we report the clinical and muscle histology associations of anti-MDA5 autoantibodies in a large cohort of predominantly Caucasian patients with juvenile-onset myositis.
Patient serum samples and clinical data were obtained through the UK Juvenile Dermatomyositis Cohort and Biomarker Study (JDCBS). The JDCBS is a large cohort of UK patients with myositis, the majority with JDM[13]. Patients are recruited consecutively on presentation to paediatric rheumatology departments across the UK, and data are collected prospectively. Children and young people aged 16 years or under are included based on a diagnosis of definite or probable JDM or polymyositis by Bohan and Peter criteria[14], as well as JDM, or polymyositis with overlapping connective-tissue disease features. Biological specimens, including sera and muscle biopsies, are collected and stored as described[13]. Ethical approval has been obtained from the North Yorkshire Multicentre Research ethics committee and this study was also approved by the steering committee of the JDCBS. Parental consent for children, and consent or age-appropriate assent was obtained for all patients in accordance with the declaration of Helsinki. Clinical data were collected on standardised proformas: data items in this analysis included demographics, the presence of ulceration, oedema, calcinosis and/or arthritis during the follow-up period, in addition to JDM disease activity measures (childhood myositis assessment score (CMAS), manual muscle testing score (MMT), serum creatinine kinase, presence of skin disease and physician global visual analogue score (PGAS). When available, muscle biopsy samples and radiographic or computed tomography (CT) images were analysed.
Remission in JDM was defined as a full-strength CMAS >48[15], the absence of skin disease (no rash, Gottron's papules, oedema, or ulceration) and a PGAS <1. Whilst this definition of remission has not been validated all features listed are standard outcome measures in JDM. Where possible we also utilised the recently proposed Paediatric Rheumatology International Trials Organisation (PRINTO) criteria for disease inactivity in JDM, defined as at least three out of the four following criteria; creatinine kinase ≤150, CMAS ≥48, MMT ≥78 and PGAS ≤0.2[16].
MSA detection
Serum or plasma was available from 285 patients. Samples were all stored at −80°C prior to analysis. Immunoprecipitation of radiolabelled K562 cells was performed to determine the presence of autoantibodies. The presence of anti-MDA5 was confirmed using ELISA.
Sera (10 μl) was mixed with 2 mg protein-A-Sepharose beads (Sigma, UK) in IPP buffer (10 mM Tris-Cl pH 8.0, 500 mM NaCl, 0.1% v/v Igepal) at room temperature for 30 minutes. Beads were washed in IPP buffer prior to the addition of 120 μl (35S)methionine-labelled K562 cell extract in IPP buffer. Samples were mixed at 4°C for 2 h. Beads were washed in IPP buffer and TBS (10 mM Tris-Cl pH 7.4, 150 mM NaCl) before being resuspended in 50 μl SDS sample buffer (Sigma, UK). After heating, proteins were fractionated by 9% SDS-PAGE gels, enhanced, fixed and dried. Labelled proteins were analysed by autoradiography.
ELISAs were performed as previously described[2] with some modifications: 96-well polystyrene plates were coated with rMDA-5 (Origene, USA) at 4°C for 16 h. Serum samples were diluted to 1:250. Secondary antibodies were conjugated goat anti-human IgG/M antibodies (Sigma, UK). Tetramethybenzidine liquid substrate (Sigma, UK) was then added (10-minute incubation). All samples were tested in duplicate and optical density was read at 450 nm using an automatic plate reader. The negative cut off was defined as >3 SD above the mean in serum from 34 normal healthy (adult) controls.
Indirect immunofluorescence
Indirect immunofluorescence was performed on HEp-2 cells (Immunoconcepts, USA) according to manufacturers' instructions. Samples were diluted to 1 in 40.
Where ANA was positive, ENA (including anti-Ro52) were looked for by immunoblot according to manufacturer's instructions, (ANA profile 5, Euroimmun, Germany).
Muscle Biopsy
Biopsies were processed, stained and scored using the International JDM score tool as described[17]. All biopsy scores were agreed by an experienced paediatric neuropathologist (TSJ) who was blinded to autoantibody and clinical data.
Pulmonary involvement
Where available, chest imaging obtained during routine clinical care was reviewed by a single experienced thoracic radiologist (CO). Images were initially reviewed blind, following which, clinical data were made available, including pulmonary function tests (PFTs) and aspiration risk, to assist with interpretation.
Statistical analysis
Statistical analysis was performed in SPSS. Potential differences between two groups were assessed using Chi-squared analysis with Yate's continuity correction or Fisher's exact test for groups with small numbers. The Mann-Whitney U-test was used to compare non-normally distributed continuous data.
Demographic characteristics of the 285 patients in this study
All JDM patients, n = 285
Anti-MDA5-positive patients, n = 21
Female, number (%)
206 (72)
15 (71)
Caucasian, number (%)
220 (78)
16 (76)b
Diagnosis, number (%) a
242 (85)
21 (100)
1 (0.4)
33 (12)
Age at disease onset, years, median (IQR)
6.3 (IQR 4 to 10)
6.6 (IQR 4 to 10)
Length of follow up, years, median (IQR)
9 (IQR 5 to 12)
8 (IQR 5 to 11)
Highest ever CK, u/l, median (IQR)
220 (IQR 111 to 1132)
129 (88 to 157)
Cutaneous and joint disease
Anti-MDA5 autoantibodies were significantly associated with the occurrence of both skin ulceration (52% anti-MDA5 positive versus 27% anti-MDA5 negative, P = 0.03) and oral ulceration (71% anti-MDA5 positive versus 45% anti-MDA5 negative, P = 0.01) occurring at any time point during the follow-up period but not with oedema or calcinosis. As expected the large majority of all the JDM cases (76%) had Gottron's papules and/or heliotrope rash (85%), but there were no significant associations between presence of anti-MDA5, and Gottron's papules or heliotrope rash. Despite the association with skin ulcerations we noted that no child with anti-MDA5 autoantibodies had a history of bowel vasculitis. There were more children with arthritis in the anti-MDA5-positive group: 86% of those with anti-MDA5 autoantibodies had arthritis compared to 51% of those without (P <0.01). In those with anti-MDA5 and arthritis 46% had symmetrical polyarthritis involving the small joints of the hands.
Muscle disease
Muscle disease in those with anti-MDA5
Anti-MDA5 autoantibody-positive
Anti-MDA5 autoantibody-negative
Muscle strength
Median lowest ever recorded CMAS (IQR)a
46 (38 to 52)
40 (27 to 48)
Muscle histology
Median biopsy score (IQR) (17)b
Inflammatory (0 to 12)c
2 (2 to 4.8)
7 (5.5 to 9.5)
Vascular (0 to 3)c
0 (0 to 0)
1 (0 to 2)
Muscle fibre (0 to 10)c
2 (1, 2)
7 (4 to 9)
Connective tissue (0 to 2)c
0 (0 to 0)
1 (0 to 1)
Total (0 to 27) c
4 (3.25 to 8.5)
15 (12.5 to 21)
VAS severity (0 to 10) c
2 (2)
5 (3.6 to 8)
Muscle biopsies were available for 11 patients with anti-MDA5. These 11 biopsies, plus 30 others (randomly selected from JDM patients without anti-MDA5 autoantibodies) were scored using the previously published and validated JDM biopsy score tool, (Table 2)[17, 18]. This tool assesses severity of pathological change in four domains (inflammatory, muscle fibre, vascular, connective tissue), leading to an overall score, and a score of 0 to 10.0 on a visual analogue scale (VAS) for assessment of severity[17, 18].
Mean total biopsy scores and VAS scores for severity were significantly lower in those with anti-MDA5, (both P <0.001). The difference in total biopsy scores between the two groups lay in a more destructive histological pattern in the non-anti-MDA5 group with significant differences in score within all four domains (inflammatory, P = 0.001; vascular, P = 0.004; muscle fibre, P <0.001 and connective tissue, P <0.003).
Pulmonary disease
Chest imaging had been performed in 12 patients with anti-MDA5 and 9 had imaging studies available for review (7 patients with CT and 2 with radiographs). Three patients had chest radiographs previously reported as showing no abnormality; these were not available to re-review. As chest imaging was performed as part of routine care it was variably timed post diagnosis (up to 68 months). A request for imaging generally coincided with either time of diagnosis or when the patient reported respiratory symptoms. No patients with abnormal PFTs went on to have high-resolution computed tomography (HRCT).
Two patients, both aged 8 years at diagnosis, had definite radiological changes consistent with ILD (as demonstrated on HRCT performed at 16 and 27 months post diagnosis). Both patients had abnormal PFTs, although in the later test, forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) were only slightly reduced (78 and 86% predicted respectively) despite extensive changes on HRCT. DLCO was not performed. Two further patients aged 4 and 2 years at diagnosis had abnormal imaging probably consistent with ILD; one with ground-glass changes on chest radiography but with no further imaging or PFTs performed, and one with extensive reticular changes on CT with radiologic appearances consistent with ILD, aspiration and/or infection. For the latter patient, taken in the clinical context this was felt most likely to represent ILD. The incidence of ILD in this group, therefore, appears to lie between 10 and 19%, although this may be an underestimate as nine patients had no chest imaging available, and for some patients the available imaging was performed many months post diagnosis.
Where ILD was demonstrated the radiological appearance was consistent with non-specific interstitial pneumonia and some patients had elements of organising pneumonia. Histology was not available to confirm the disease pattern. Of the two patients with definite ILD on imaging, both had follow-up images available, which demonstrated significant radiological improvement following treatment with intravenous cyclophosphamide.
Disease outcome
Disease outcome was assessed at 2 years (range 20 to 28 months) post diagnosis and again at the last clinic visit, where this occurred 4 or more years post diagnosis, (mean 7.1 years in the anti-MDA5-positive group and 7.9 years in the anti-MDA5-negative group). Data were not yet available at 2 years post diagnosis when children had been diagnosed with JDM less than two years previously, had been recruited into the study more than 20 years post diagnosis or had not been reviewed between 20 and 28 months post diagnosis. Information was available for 151 of 285 (53%) children at 2 years post diagnosis (12 with anti-MDA5) and 136 children (48%) at more than 4 years post diagnosis (9 with anti-MDA5 autoantibodies).
Outcome at 2 and >4 years post diagnosis for affected children with and without anti-MDA5 antibodies
Two years post diagnosis
More than four years post diagnosisa
Anti-MDA5 present
Anti-MDA5 absent
Anti-MDA5 present
Anti-MDA5 absent
Inactive disease
6 (50%)b
30 (22%)
6 (66.6%)
59 (46%)
Active disease
6 (50%)b
109 (78%)
3 (33.3%)
68 (54%)
PRINTO inactive disease
7 (87%)b
44 (43%)
4 (100%)
51 (71%)
PRINTO active disease
1 (13%)b
59 (57%)
0 (0%)
21 (29%)
Given the association of anti-MDA5 autoantibodies with ulceration and ILD, which are both considered to be features of severe disease, we investigated whether these patients were more likely to be targeted for aggressive treatment. Slightly more patients with anti-MDA5 had received cyclophosphamide treatment than those without but this difference was not significant, with 29% compared to 21% of those without. Likewise no significant difference was seen in the proportion receiving methotrexate treatment (90% of those with anti-MDA5 versus 93% without). At 4 or more years post diagnosis no statistically significant difference in disease activity was seen but more children with anti-MDA5 had inactive disease (Table 3).
The identified prevalence of anti-MDA5 in 7.4% of the patients should be considered a minimum, as whilst the earliest available serum sample was used for autoantibody detection, this was often months post diagnosis. Sato et al. demonstrated a fall in anti-MDA5 titre in response to treatment and it is therefore possible that some autoantibody-negative patients in our cohort were treated patients with anti-MDA5[19].
Anti-MDA5 autoantibodies were first described in adults with amyopathic myositis and rapidly progressive ILD: amyopathic myositis is recognised in children but it is rare, and more often patients have mild or progressive muscle disease[20, 21]. We have previously shown that histological features on biopsy are very mild in cases of amyopathic JDM, and include absence of upregulation of major histocompatibility complex (MHC) class I protein, which is usually found in JDM biopsy tissue from more typical cases[22]. The data presented here suggest that in JDM anti-MDA5 antibodies are associated with mild muscle involvement, both clinically and histologically. To our knowledge this is the first report of quantitative biopsy scoring in an autoantibody-specific subgroup and suggests that in addition to clinical phenotype, autoantibodies may also reflect variations in underlying muscle pathology.
Similar to previous studies in US and European adults, anti-MDA5 autoantibodies are associated with less severe muscle disease and a characteristic cutaneous phenotype, and in particular, ulcerative skin disease[6, 23]. Whilst skin ulceration is generally considered one of the most severe cutaneous manifestations of JDM, there was no significant association with other severe cutaneous disease features, such as oedema or calcinosis. The association with arthritis and anti-MDA-5 antibodies has also been described in US adults[6, 8]: in one study several adult patients had even initially been suspected to have rheumatoid arthritis[8]. Although we did not analyse disease presentation in this study, it seems likely that some juvenile patients could be similarly misclassified. We suspect that this sub-group of patients may often present as a diagnostic conundrum with rash, ulceration and polyarthritis but minimal muscle disease.
Anti-MDA5 autoantibodies have been associated with a poor prognosis in adult East-Asian cohorts due to the association with rapidly progressive ILD[4, 24]. This has also been described in Japanese juvenile-onset patients with anti-MDA5[9]. In our cohort, 19% of those with anti-MDA5 had radiological evidence of ILD. A large US study of clinical phenotype of juvenile myositis patients reported an incidence of ILD of 4.8% in those with JDM[25]. Anti-MDA5 antibodies in our cohort were mutually exclusive and specifically no patient had additional anti-synthetase antibodies. It thus appears highly probable that anti-MDA5 is associated with ILD in JDM: larger future studies will be required to confirm this.
One limitation of this study is that not all of the cases in this study had chest imaging available to review and where imaging was available this was often some months post diagnosis and following treatment. Furthermore, radiograhy is an insensitive tool in excluding ILD, and approximately 10% of patients with ILD detected on HRCT have a normal chest radiograph, especially early in the disease[26]. While our estimates of the prevalence of ILD in the anti-MDA5 subpopulation may therefore be an underestimate, particularly if some children have mild ILD, which responds to standard therapies, it does accurately represent the proportion with ILD diagnosed during routine clinical practice. A retrospective study of pulmonary outcome in JDM in a Norwegian population reported a previous diagnosis of ILD in 3 out of 59 patients (5%), one of whom was known to have anti-Jo1 antibodies[27]. A further four patients, however, were identified as having evidence of ILD on subsequent HRCT. Anti-MDA5 antibody status was not reported but interestingly these four patients all had arthritis and skin ulcers[27]. Anti-synthetase autoantibodies, which are associated with ILD, are rare in JDM. Interestingly, of the six patients in our cohort with anti-synthetase autoantibodies, four had evidence of ILD, suggesting that they confer a greater risk of developing ILD than anti-MDA5, although the incidence in those with anti-Jo-1 autoantibodies (three patients) was similar (33%).
Our findings also highlight the relative infrequency of chest imaging by CT in children with JDM, in the UK, in part secondary to concerns with regard to radiation exposure and the perceived low incidence of lung disease. Assessment for the presence of anti-MDA5 autoantibodies would be useful to help target patients in whom careful repeat chest imaging may be recommended. This would be particularly valuable in patients diagnosed at a young age, when PFTs cannot be performed.
Importantly and similar to adult Caucasian patients with anti-MDA5[6, 8], no patients had rapidly progressive ILD. Furthermore, the response to treatment appeared to be good with significant improvement seen on follow-up imaging where this was available.
Interestingly, despite associations with ulceration and probably ILD, both considered poor prognostic features, significantly more children with anti-MDA5 were in remission at 2 years post diagnosis than the rest of the cohort.
At present diagnostic testing for anti-MDA5 is available at a limited number of centres worldwide. Standard laboratory techniques, including indirect immunofluorescence, are of limited benefit and are likely to provide negative or non-specific results. Whilst one study did report a granular/reticular cytoplasmic speckle in anti-MDA5 positive patients[28] this has not been our experience and may depend on the exact technique used. Furthermore, this pattern is non-specific and may not be reported by many laboratories. An association between anti-Ro52 and anti-MDA5 has been noted in two adult studies[6, 8]. We did not identify co-existent anti-Ro52 autoantibodies in any of our patients with anti-MDA5. There is growing interest in more widespread testing for myositis-specific autoantibodies using standard laboratory techniques: line blot kits, which include anti-MDA5, have been developed and will shortly be commercially available. We anticipate that in the future testing for the presence of anti-MDA5 autoantibodies where JDM or JDM overlap-syndromes are suspected will become standard clinical practice.
Anti-MDA5 autoantibodies can be identified in a small but significant proportion of UK patients with JDM. The particular clinical phenotype of this subgroup is similar to that described in predominantly Causcasian adult cohorts but appears to differ from that described in East-Asian populations. The identification of anti-MDA5 at diagnosis would be useful to guide further investigation for possible lung disease, inform on prognosis and potentially to confirm the diagnosis, as subtle biopsy changes could otherwise be missed.
antinuclear antibody
childhood myositis assessment score
computed tomography
diffusion capacity
enzyme-linked immunosorbent assay
extractable nuclear antigen
high-resolution computed tomography
interstitial lung disease
Juvenile Dermatomyositis Cohort and Biomarker Study
juvenile dermatomyositis
manual muscle testing score
pulmonary function test
physician global assessment score
Paediatric Rheumatology International Trials Organisation
visual analogue scale.
The members of the JDRG were as follows: Dr Liza McCann, Mr Ian Roberts, Dr Eileen Baildam, Ms Louise Hanna and Ms Olivia Lloyd (The Royal Liverpool Children's Hospital, Alder Hey, Liverpool), Dr Phil Riley and Ms Ann McGovern (Royal Manchester Children's Hospital, Manckhester), Dr Clive Ryder and Mrs Janis Scott (Birmingham Children's Hospital, Birmingham), Dr Sue Wyatt, Mrs Gillian Jackson, Dr Tania Amin, Dr Mark Wood and Vanessa VanRooyen (Leeds General Infirmary, Leeds), Dr Joyce Davidson, Dr Janet Gardner-Medwin, Dr Neil Martin, Ms Sue Ferguson and Ms Liz Waxman (The Royal Hospital for Sick Children, Yorkhill, Glasgow), Dr Mark Friswell, Professor Helen Foster, Mrs Alison Swift, Dr Sharmila Jandial, Ms Vicky Stevenson, Ms Debbie Wade, Dr Ethan Sen, Dr Eve Smith and Ms Lisa Qiao (Great North Children's Hospital, Newcastle), Dr Helen Venning, Dr Rangaraj Satyapal, Mrs Elizabeth Stretton and Ms Mary Jordan (Queens Medical Centre, Nottingham), Dr Kate Armon, Mr Joe Ellis-Gage and Ms Holly Roper (Norfolk and Norwich University Hospitals), Professor Lucy Wedderburn, Dr Clarissa Pilkington, Dr N. Hasson, Mrs Sue Maillard, Ms Elizabeth Halkon, Ms Virginia Brown, Ms Audrey Juggins, Dr Sally Smith, Mrs Sian Lunt, Ms Elli Enayat, Mrs Hemlata Varsani, Miss Laura Beard, Miss Laura Kassoumeri, and Miss Katie Arnold (Great Ormond Street Hospital, and UCL London), Dr Kevin Murray (Princess Margaret Hospital, Perth, Western Australia) Dr John Ioannou and Ms Linda Suffield (University College London Hospital). The UK JDM Cohort and Biomarker study has been supported by generous grants from the Wellcome Trust UK (085860), Action Medical Research UK, (SP4252), The Myositis Support Group UK, Arthritis Research UK (14518), and The Henry Smith Charity. The JDM Cohort study is adopted onto the Comprehensive Research Network through the Medicines for Children Research Network (http://www.mcrn.org.uk). ST and this project were funded by the BMA Doris Hillier grant 2012. TSJ holds a HEFCE Clinical Senior Lecturer Award. This report is independent research supported by the National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health.
Authors' Affiliations
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- McCann LJ, Li CKC, Varsani H, Wedderburn LR, Pilkington CA: Failure to over express MHC-CLASS-1 on muscle biopsy in a case of amyopathic juvenile dermatomyositis. Clin Exp Rheumatol. 2007, 25: 96-98.PubMedGoogle Scholar
- Allenbach Y, Leroux G, Uzuhnan Y, Valeyre D, Saadoun D, Aubart F, Hervier B, Hie M, Wipff J, Myiara M, Charuel JL, Musset L, Audia S, Devillier H, Bonnote B, Barete S, Nimal N, Rigolet A, Herson S, Benveniste O: Dermatomyositis associated with MDA-5 antibodies: Report of the first European series [abstract]. Neuromuscular Disorders. 2013, 23 (9): 813-814.View ArticleGoogle Scholar
- Hoshino K, Muro Y, Sugiura K, Tomita Y, Nakashima R, Mimori T: Anti-MDA5 and anti-TIF1- antibodies have clinical significance for patients with dermatomyositis. Rheumatology. 2010, 49: 1726-1733. 10.1093/rheumatology/keq153.View ArticlePubMedGoogle Scholar
- Shah M, Mamyrova G, Targoff IN, Huber AM, Malley JD, Murguia Rice M, Miller FW Rider LG: The Clinical Phenotypes of the Juvenile Idiopathic Inflammatory Myopathies. Medicine. 2013, 92: 25-41. 10.1097/MD.0b013e31827f264d.PubMed CentralView ArticlePubMedGoogle Scholar
- Ryu JH, Daniels CE, Hartman TE, Yi ES: Diagnosis of Interstitial Lung Diseases. Mayo Clin Proc. 2007, 62: 976-986.View ArticleGoogle Scholar
- Sanner H, Aalokken TM, Gran JT, Sjaastad I, Johansen B, Flato B: Pulmonary outcome in juvenile dermatomyositis: a case to control study. ARD. 2010, 70: 86-91.PubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


text:
18+ Adult Website
- Status Completed
- Budget N/A
- Total Bids 18
Project Description
18+ adult website.
I need a site similar to v|i|d|e|o|s|e|x|a|r|c|h|i|v|e|.com. Remove all the "|".
It has to be fully operational on delivery.
The site is pretty simple. The only thing that is "advanced" is the WebCrawler.
The site will feature links.
It will embed videos from other sites, similar to the example above.
The site has to update itself automatically through a WebCrawler.
The WebCrawler must follow the standard WebCrawler ethics and still be very effective:
[url removed, login to view](REMOVETHIS)[url removed, login to view](REMOVETHIS)/wiki/Web_cra(REMOVETHIS)wler#Politeness_policy
The WebCrawler gathers information (links to embed videos) from other sites, then uses the information to create a page on my site.
The example I listed above illustrates what I want, but with a focus on a more clean design.
Some functions I need for the site:
- WebCrawler
- Simple User profiles
- Password recovery
- Admin panel
- Reporting videos/comments
- Like/dislike
- Related videos
- "Panic button"
- Captcha or similar function
- Categories and tags
- Ads
- Search
- and more
I will provide hosting and domain.
I am looking for a worker that is effective, serious, adjustable, innovative, cooperative and willing to be hired again to help out with future challenges if required.
More information regarding functions if you are being considered.
Thank youGet free quotes for a project like this
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text: Hang Your Paintbrush in a Jar of Paint ThinnerDavid Galloway8/12/12 3:00pmFiled to: PaintingPaint thinnerpegboard35EditPromoteShare to KinjaToggle Conversation toolsGo to permalink In order to clean your paintbrush sometimes you need to let it soak in paint thinner, but you don't want the bristles touching the bottom as they will both bend and pick up residual paint from the bottom of the paint thinner jar. Instead, hang your paintbrush from an object such as a pegboard into a jar of paint thinner. Advertisement This tip comes from household weblog Chez Larsson. Hanging the paintbrush using a pegboard or other method where the tip of the bristle is an inch from the bottom of the paint thinner jar is the best location.Painting Trick & Tip | Chez LarssonReply35 repliesLeave a reply


text:
Speed up your debug routine!
Automated exception search integrated into your IDE
Tired of useless tips?
Received Facebook error response of type OAuthException: Error validating
access token: Session has expired on Thursday, 09-Apr-15 17:00:00 PDT. The
current time is Thursday, 09-Apr-15 17:37:09 PDT. (code 190, subcode 463)
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Designed for today's plugged in youth with smart features, fun add-ins, and tons of storage, #myRoom is trending with kids and parents alike. The nursery and youth bedroom collection has a dorm-room vibe, with streamlined silhouettes, modern detailing, and two two-tone finish options that are youthful and stylish. With its neutral tones and simple design, #myRoom has a versatile look equally suited for a boy or girl's bedroom, and though it's perfectly on-trend, the collection has a timeless quality that will remain in style as your child grows from crib to college. Features like built-in charging stations, Flex LED reading lights, and corkboards give kids the freedom to stay connected and express their personality, while inclusions like underbed storage, drawer partitions, and extra safety features will keep parents satisfied. So tweet, instagram, and text away; #myRoom brings the fun features and style that kids want and the safety, construction, and organization that parents require. Finally, something that kids and parents can agree on.
Browse other items in the #myRoom collection from Becker Furniture World in the Twin Cities, Minneapolis, St. Paul, Minnesota area.
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text:
Right now, if a compartment is created during an incremental GC, we reset the current GC and finish with a non-incremental GC. This seems to happen pretty frequently during normal browsing.
In theory, we should be able to carry on with the GC as normal without touching the new compartment (i.e., don't mark it and don't collect any of its objects). In practice, this could be a little difficult since it will be hard to avoid marking into the new compartment. Bug 716142 may simplify the problem: maybe we could switch the GC to a multi-compartment GC of every compartment except the newly-created one.
Created attachment 612375 [details] [diff] [review]
Now that multi-compartment GC has landed, we can make headway on this. Unfortunately, the multi-compartment GC patch preserved a difference between "full" GCs and compartment GCs (even if the compartment GC collected every compartment). This patch removes that distinction.
The main changes in behavior from this patch are:
1. If a compartment is created during an incremental GC, we don't reset the GC or switch to non-incremental GC. In fact, we don't do anything. The new compartment won't be collected.
2. We now collect atoms only if every compartment that existed at the beginning of the GC is being collected.
3. Now any GC can delete a compartment if it has no live objects. Previously only "full" GCs could do this.
Note that most of the time we'll still collect all compartments. It's just that collecting all compartments is no longer a special case.
Comment on attachment 612375 [details] [diff] [review]
Review of attachment 612375 [details] [diff] [review]:
nice cleanup!
::: js/src/jsatom.cpp
@@ +241,5 @@
> return true;
> }
> void
> +js::FinishCommonAtoms(JSContext *cx)
As you are changing this, replace the cx argument with the rt here
::: js/src/jsgc.cpp
@@ +2277,5 @@
> + if (!c->isCollecting())
> + isFullGC = false;
> + }
> + }
> + MarkAtomState(trc, rt->gcKeepAtoms || !isFullGC);
We need a bug to stop marking atoms when the atom compartment is not under the GC itself.
*** Bug 742003 has been marked as a duplicate of this bug. ***


text:
The Bank of England will gain some respite in its battle against the rising cost of living this week as figures reveal a sharp fall in inflation during April.
The Bank's inflation benchmark, the Consumer Prices Index, is predicted to slip back to 3.1 per cent after March's first rise in six months to 3.5 per cent.
The fall would still leave the cost of living well above the Bank's2 per cent target, where it has been stuck since 2009, due to VAT hikes and rising global commodity prices.
The Bank has warned that inflation is unlikely to drop back to the target until the middle of next year.
The improvement is likely to have been driven by the last of the price cuts from the energy companies. The Easter holiday falling two weeks earlier than last year also means a longer post-Easter sales period as well as cheaper air fares, said Lloyds Bank Corporate Markets' senior UK economist, David Page.
But Mr Page expects April's fall to be unwound in May as higher water bills kick in. "The general trend is that there are some upward pressures coming through. We are expecting sticky inflation above 3 per cent throughout the summer."
Falling oil prices should eventually feed into lower petrol prices, although this may not be felt in the official inflation figures until next month, Mr Page added.
Philip Shaw, Investec's chief economist, said that the coalition's controversial trebling of tuition fees from the autumn would also keep up the inflation pressure.
Minutes of the Bank's latest policy meeting, where it decided to draw a halt to its quantitative easing (QE) programme to stimulate growth, will also be scoured by experts next week, with a split decision anticipated. The Monetary Policy Committee member David Miles is expected to have voted for more money printing, while fellow member Adam Posen has signalled that he is ready to rejoin the QE camp next month after over-estimating the strength of the UK's recovery earlier this year.
Mr Page said the Bank could be keeping back QE as a "shot in the locker" for any intensification of the eurozone crisis, as well as being reluctant to offer more stimulus against a backdrop of rising inflation.
- More about:
- Air Transport
- Banking
- Holiday
- Inflation
- Lloyds TSB


text:
About Goodbye Blue Monday
San Diego-based indie rock band Goodbye Blue Monday updates the work of '80s new wave giants like the Cure and U2 for new-millennium consumption. The group's first release, 2003's Next Time We Stop Breathing, was followed by various changes in lineup, after which current members Matt Mournian (vocals/guitar), Demetrius Antuna (guitar), Dario Izarraras (bass), and Jason Hooper (drums) issued their second effort, Help Is On the Way, in 2005. ~ Eduardo Rivadavia, Rovi


text:
January 22, 2013 was the 40th anniversary of Roe v. Wade, the 1973 decision by the Supreme Court which declared that abortion was a woman's constitutional right. The occasion, as every year on that date, was observed by the annual March for Life in which many thousands converge on Washington to protest the legalization of abortion. The event was too large to be ignored by the liberal media, though their sympathies were clearly for another Washington demonstration that occurred a few days earlier, a March for Gun Control (which was triggered by the massacre at the elementary school in Newtown, Connecticut). Abortion and gun control have been central issues in the American culture war for many years, which makes one doubt whether there was much overlap between the two marches. Actually the pro-life event was preceded a little earlier by Gun Appreciation Day, a celebration of the Second Amendment supported by the National Rifle Association.
This is not the place to discuss the merits of the debates over either issue. [Since you ask: My views on abortion are not easily labeled as either pro-life or pro-choice. On gun control they are "un-evolved", because I am not familiar with the empirical evidence on guns and violent crime.] What interests me here is one curious fact: The discrepancy between public attitudes toward abortion and toward homosexuality. One might intuit that attitudes toward the two topics would strongly correlate. It seems that they don't.
A Pew Research Center poll released in January 2013 showed 29% of Americans favoring a repeal of Roe v. Wade, 69% opposing a repeal. This might be interpreted as indicating a sizable pro-choice majority. But the situation is more complicated. Different surveys show that, while the overall size of the two camps has remained quite stable over the years (a few points apart in the 40-some% range), there has recently been a slight surge, even among young people, putting the pro-life numbers slightly up over pro-choice. The "salience" of the issue has declined: a slight majority now says that it is "not that important". Given the very strong pro-life position of the Roman Catholic Church, it is also interesting that more Evangelicals than Catholics say that the issue is very important.
I think that the survey data suggest that a lot of Americans are confused about the issue of abortion. They drift toward a middle position. They are basically against abortion, but they don't want it to be illegal again, though they are willing to consider some limitations (such as parental approval for minors, counseling requirements, banning very late-term abortions). In other words, public opinion has remained quite stable, and stably divided, over time. But there has been a slight increase in the pro-life numbers. These findings are puzzling when one compares them with those concerning homosexuality: Public opinion in recent years has become much more positive on all matters involving homosexuality, including same-sex marriage. The Pew Research Center has logged the change: In 2001 about 33% of both white and black Americans supported same-sex marriage, in 2012 the white figure is 49% (African-Americans are behind at 40%).
The data on homosexuality are not surprising: They are in line with a well-documented increase in tolerance toward all sorts of minorities (sexual as well as ethnic and religious), and it is also congruent with an increasing acceptance of gender equality. The data on abortion attitudes are surprising. How could they be explained? I am not sure, but I am prepared to speculate. I can think of four possible explanations.
First, there may be a technological factor. Ultrasound imagery has made it possible to see an embryo as never before. Especially in later stages of pregnancy, both the humanity and the vulnerability of the embryo is strongly conveyed. Such images have been widely diffused, in the media and often by proud parents-to-be. It seems plausible that this may have made for repugnance against aborting this human being in the making.
Secondly, I think that the aggressive insistence by pro-choice activists that abortion is a fundamental human right of a woman, regardless of any circumstances (such as late-term pregnancy), has been counterproductive. This revulsion probably increased after Congress banned so-called "partial- birth abortion" in 2003 (the ban was upheld by the Supreme Court in 2007). This procedure has been used with very late pregnancies: Labor is artificially induced, and the embryo is then destroyed as it emerges (frequently by crushing its head). Not surprisingly, the procedure has seemed barbaric to many people, and its fierce defense by many in the pro-choice movement has been particularly appalling to people otherwise tolerant of abortion. Relevant to this topic is the question of "viability"—the ability of an embryo to survive outside the mother's womb. Most embryos are viable after the 27th week of pregnancy, virtually none before the 21st week. Aborting late-term pregnancies is thus especially problematic, even if the mother's health is at issue.
Thirdly, unless survey questionnaires go into very great detail, the wording of the questions is often ambiguous and answers may therefore be misleading. Just what is meant by a respondent claiming to be "pro-life" or "pro-choice", for or against repealing Roe v. Wade? The simple self-identification in terms of either category leaves out any complicating circumstance. And individuals may have a more nuanced attitude toward the 1973 Supreme Court decision. Thus one may be broadly in favor of abortion, but not on the debatable grounds on which the decision was based (such as the imputation of a "right to privacy" to the "due process" clause of the 14th Amendment).
Finally, and probably most importantly (at least for more reflective individuals), there is a fundamental ambiguity to the labels "pro-life" and "pro-choice". "Pro-life": Of course an embryo is, biologically speaking, human life. So was my appendix, when it was removed when I was about twelve; it was not canine life. The question is not whether the embryo is human life, but whether he or she is a human person. There are various religious authorities, from the Pope on down, who claim to know. I don't. This is a mystery (in the full sense of the word) that is not resolved by hoisting a banner that says "pro-life". I would ask some of those who claim certainty whether they would want to charge a woman with murder (first-degree?) for aborting an embryo one month after conception. "Pro-choice": Of course a woman has the right to choose what to do with her own body. The question is where her own body ends and that of another person begins—and when. I would ask those who, in tones of certainty, insist on the right of a woman to have an abortion a month before birth whether she also has the right to kill the child a month after birth—and if not, why not. While raising such questions does not lead to apodictic assurance in terms of policy, they may induce a measure of humility—precisely humility before the mystery of the human condition. Needless to say, individuals who ask such questions will have difficulty identifying themselves unambiguously as either "pro-life" or "pro-choice".
Abortion continues to be a key question in the ongoing American culture war between conservatives and progressives. Various data have shown that it is symbolic of a lot of other questions that divide the two camps. The issue is unlikely to go away any time soon.


text:
The specific aims of the Biorepository Shared Resource are (1) to facilitate the TREC Center research projects by providing expertise and centralized service in the collection, processing, analysis and management of biological samples, and (2) to serve as a source of biological samples for ancillary and future studies during and beyond the TREC Center operation, because biological samples may be made available for use in research as new knowledge in this area evolves. The core faculty and staff also will provide expert guidance into final selection of assays and laboratories for TREC Center project biological sample analysis, ensuring that analytical laboratories are monitored for quality control (QC) data and activities. The core personnel, who have specialized training and expertise, will facilitate appropriate biological sample collection and processing methods, materials, and procedures to ensure that the data and results produced by TREC Center projects are of good quality to enable the aims to be optimally addressed. A key component ofthe Biorepository Shared Resource is a computer-based system to log and track all samples and aliquots, so that analyses of TREC Center projects are efficient and the likelihood of misplaced samples and missing data is minimized. Core personnel will use equipment and instrumentation that is high-quality, and well-maintained. Providing the materials and services necessary for biological sample collection and management through a centralized core will ensure quality and efficiency for the TREC Center research projects.
|Hartman, Sheri J; Marinac, Catherine R; Natarajan, Loki et al. (2015) Lifestyle factors associated with cognitive functioning in breast cancer survivors. Psychooncology 24:669-75
|Chung, H; Lee, Y S; Mayoral, R et al. (2015) Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene 34:3504-13
|Emond, Jennifer A; Pierce, John P; Natarajan, Loki et al. (2014) Risk of breast cancer recurrence associated with carbohydrate intake and tissue expression of IGFI receptor. Cancer Epidemiol Biomarkers Prev 23:1273-9
|James, Peter; Berrigan, David; Hart, Jaime E et al. (2014) Effects of buffer size and shape on associations between the built environment and energy balance. Health Place 27:162-70
|Patterson, Ruth E; Rock, Cheryl L; Kerr, Jacqueline et al. (2013) Metabolism and breast cancer risk: frontiers in research and practice. J Acad Nutr Diet 113:288-96
|Schmitz, Kathryn H; Neuhouser, Marian L; Agurs-Collins, Tanya et al. (2013) Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity. J Natl Cancer Inst 105:1344-54


text:
7229 Pacific Circ, Mississauga, ON - W2466728
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This real estate property is located at 7229 Pacific Circ in Northeast (Cooksville and City Centre). Other areas in the vicinity are: Applewood Acres, Cooksville, Dixie, Fairview, Malton.
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Cooksville and City Centre has 617 homes and condos for sale. Of those, 161 real estate listings are currently available in Northeast. The average house price in Cooksville and City Centre right now is $340,500.


text:
Anger: Wisdom for Cooling the Flames
Riverhead Books, 2002 - Philosophy - 227 pages
"[Thich Nhat Hanh] shows us the connection between personal, inner peace and peace on earth." -His Holiness The Dalai Lama
Nominated by Martin Luther King, Jr. for a Nobel Peace Prize, Thich Nhat Hanh is one of today's leading sources of wisdom, peace, compassion and comfort.
It was under the bodhi tree in India twenty-five centuries ago that Buddha achieved the insight that three states of mind were the source of all our unhappiness: wrong knowing, obsessive desire, and anger. All are difficult, but in one instant of anger--one of the most powerful emotions--lives can be ruined, and health and spiritual development can be destroyed.
With exquisite simplicity, Buddhist monk and Vietnam refugee Thich Nhat Hanh gives tools and advice for transforming relationships, focusing energy, and rejuvenating those parts of ourselves that have been laid waste by anger. His extraordinary wisdom can transform your life and the lives of the people you love, and in the words of Thich Nhat Hanh, can give each reader the power "to change everything."
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Anger: Wisdom for Cooling the FlamesUser Review - Not Available - Book Verdict
"You cannot eat raw potatoes," charmingly states Nobel Peace Prize nominee and best-selling author Thich Nhat Hanh (Living Buddha, Living Christ). He then describes how the deep, compassionate ... Read full review
Review: Anger: Wisdom for Cooling the FlamesUser Review - Mike Lawrance - Goodreads
this book teach me how to awareness and cooling down when anger arising. Read full review
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Friends on the Path: Living Spiritual Communities
Thich Nhat Hanh,Jack Lawlor
No preview available - 2002


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Wego.com recently found 2 hotels in Hartenstein, Germany. Find a range of accommodation in Hartenstein at great prices. Book luxury Hartenstein hotels or find last minute accommodation. Save more on cheap hotels in Hartenstein with affordable room rates.
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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: BUFFALO LS-V2.0TL 2TB LinkStation Pro LS-VL Network Storage
Pros: Supposed to be compatible with Windows
Cons: Not really compatible with OSX. I should've researched on the Buffalo (and other) forums before purchasing.
Other Thoughts: I ran into more problems with corrupted files and permissions when trying to copy from my OSX iMac to this NAS (Buffalo LS-VL NAS). I had high hopes but ran into nothing but problems. The online forums indicate that Buffalo support leaves much to be desired... very unfortunate and will be looking for another NAS solution.READ FULL REVIEW


text:
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text:
The Paris Commune of 1871 - Undercurrent
Short text about the Commune by Undercurrent, as the University of Sussex unveils a flawed exhibition on the uprising.
The Commune: Paris 1871 – P. Guillaume and Martin Grainger
Industrial collectivisation during the Spanish revolution - Deirdre Hogan
A soldier returns - letter from an American fighter in the Durruti Column
A letter from an American trade unionist and member of the revolutionary union the Industrial Workers of the World (IWW) about his experiences as a fighter in the Spanish Civil War and Revolution of 1936-9 in the International section of the anarchist Durruti Column.
A day mournful and overcast... An account of the Iron Column
A personal account of a liberated prisoner's experience as a fighter during the Spanish Civil War and Revolution of 1936-9 in the anarchist militia unit called the Iron Column prior to its incorporation into the Communist-run Republican army.
Anarchists in the Russian Revolution - Paul Avrich
Why past revolutionary movements have failed
The civil war in France - Karl Marx
Karl Marx's contemporary account of the Paris Commune, placing it in context fo the wider events in France at the time. The Paris Commune significantly changed Marx's ideas about the "Dictatorship of the Proletariat", and his support for it's organisation structures suggests a different trajectory of revolutionary organisation to the "Marxist" revolutions in the 20th Century.
The Paris Commune and the idea of the state - Mikhail Bakunin
The Commune of Paris - Peter Kropotkin
Russian anarchist Peter Kropotkin's analysis of the Paris Commune, a defining moment in revolutionary history which inspired both marxist and anarchist revolutionaries for many years afterwards, and warrants continued attention today.