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Oat Gain delivers over 600 kcals per serving and contains ground oats in addition to BIOTEINTM Xtreme. This is an exclusive whey protein based complex, created using a unique blend of whey protein concentrate enriched with organic coconut oil and 9g of naturally occurring amino acids. Organic coconut oil predominantly consists of beneficial fats - medium chain triglycerides (MCTs). MCTs are broken down in the stomach and transported to the liver where they are metabolised quicker than other fats. These high biological value and easily digested proteins support the growth and maintenance of muscle mass. Uniquely at Kinetica, we manufacture all of our own proteins in our state-of-the art dairy manufacturing facility and maintain full control over supply and selection, to ensure that the highest quality whey proteins are available to you.Oat Gain also contains added active ingredients taurine and l-glutamine, together with the digestive enzyme Aminogen® and a multi-vitamin blend. Vitamin C contributes to the reduction of tiredness and fatigue and Vitamin B6 contributes to normal protein and glycogen metabolism. Oat Gain contains natural flavours and colours only and makes a great tasting shake just add to water or low-fat milk.Like all our sports nutrition supplements, Kinetica Oat Gain is batch tested within the World Anti-Doping Agency (WADA) framework by the HFL to ISO 17025 standards. From our elite athlete customer to our regular sports users we demand and expect the same standards for all to ensure we provide a safe and dependable sports nutrition product.
Cheapest price we found
|Visit Store
Prices are updated periodically, the prices quoted here were correct at the time of last update.
Patient gathers information on a vast range of over-the-counter treatments and beauty products from reputable websites and registered online pharmacies. We perform a price comparison so that you can see who offers the best price.


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New Inn
New Inn Lane, Southbank
Opening Times
About the Pub
Situated next to the Stainforth & Keadby Canal, where many boat owners stop for a drink or something to eat. Two bars, one with a pool table, the other overlooks the canal and is furnished with dining tables. Popular with locals and canal users. Newly refurbished and decorated July 2014. Pub food recommended. Up to 2 guest beers.
Regular Beers
This pub serves 1 regular beer.
- Wells Bombardier Burning Gold
Changing Beers
This pub serves 1 changing beer.
Changing beers typically include:
- Abbeydale Moonshine
- Moorhouse's Blond Witch
- Moorhouse's Pride of Pendle
One guest beer.
- Real Ale Available
- Disabled Access
- Lunchtime Meals
- Evening Meals
- Pub Garden
- Parking
- Family Friendly
- Live Music
Restaurant Area
Full menu.
- Smoking Area
- Sports TV
- Wifi
View on Larger Map
Sat Nav Reference
- Close to Bus Routes
- Close to Railway Station
Nearby Bus Routes (100m)
First: 87
Nearby Station (1450m)
Hatfield and Stainforth
- Nearby Pubs
- Recently Viewed Pubs

subset: commoncrawl


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Authorities searching for bank robbery suspect
The robbery occurred at the Chase Bank in the 1300 block of West 86th Street.
The robbery occurred at the Chase Bank in the 1300 block of West 86th Street.
The scammer asked for a $16,000 security deposit.
Two Dartmouth College professors have created "HillaryDonald Go."
Police said there were no skid marks or indication of the car braking or slowing down.
The Indiana Blood Center held a drive until 2 p.m. Saturday afternoon.
In October 2013, the transcripts show, Clinton told bankers she had "great relations" and worked closely with Wall Street as New York's sena…
Police say, 27-year-old Nicholas Grant was found unresponsive in his cell Friday evening.
The choir performed at Butler University.
Gregg made a campaign stop at the Kountry Kitchen Saturday.
The former Republican presidential candidate made a stop in Indianapolis Saturday.
Indiana State Police have responded after being accused of voter suppression.
The deadly shooting reportedly stemmed from an argument.
Kerr is the former wife of actor Orlando Bloom.
The Republican nominee made his claims Saturday.
The man was arrested following a two-week investigation.
When the taproom isn't open the space will revert to its regular setup.
The death toll from Hurricane Matthew in North Carolina keeps climbing.


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Tough losses by Bishop Amat and Lakewood paved the way for some changes in our south Los Angeles County top 10 rankings heading into Week 7. (Note: Last week's rankings are in parentheses.)
1. (1) Long Beach Poly (6-1)
It wouldn't be Poly without a little controversy, but the two-quarterback system seems to be working for coach Raul Lara. Starter Chaiyse Hales and backup Nick Pope combined for 219 passing yards in an important Moore League win. Last week: Beat Lakewood, 38-21. Next: at Millikan, Oct. 28.
2. (3) Loyola (5-1)
No game for the Cubs last week, but they move up a spot thanks to Bishop Amat's loss to Alemany in the Serra League opener. Loyola begins the Serra against Notre Dame, which is coming off a stinging loss to Crespi. Last week: Idle. Next: vs. Sherman Oaks Notre Dame at L.A. Valley College, Friday.
3. (4) St. John Bosco (5-1)
Four more touchdown passes for Rene Medina, who is the top statistical quarterback in the Trinity League. The electrifying Bryce Treggs had a 90-yard touchdown catch and returned a punt for another score. Last week: Beat JSerra, 48-14. Next: vs. Mater Dei, Friday.
4. (2) Bishop Amat (5-2)
The troubled defense couldn't come up with a stop late in Friday's game and time simply ran out on the Lancers. Workhorse Jalen Moore had 112 yards rushing but there weren't enough big plays in important moments. Last week: Lost to Alemany, 26-21. Next: at Crespi, Friday.
5. (6) Charter Oak (5-1)
OK, who's controlling the joystick? Quarterback Travis Santiago passed for 325 yards, ran for 54 more and had five total touchdowns to open Sierra League play in fine fashion. Try doing that in a video game. Last week: Beat South Hills, 63-28. Next: vs. Ayala, Friday.
6. (7) Narbonne (4-2)
Twenty-two completions out of 29 attempts for the strong-armed Troy Williams on Friday night. The junior quarterback racked up 237 yards, bringing his total to a City Section-leading 1,549 on the season. Last week: Beat Gardena, 43-20. Next: vs. Carson, Friday.
7. (5) Lakewood (5-2)
Quarterback Brock Dale did all he could against Poly's relentless pressure but, more often than not, wound up on the turf. Darius Powe and Malik Gilmore had touchdown receptions but the offense was stagnant. Last week: Lost to Long Beach Poly, 38-21. Next: at Cabrillo, Friday.
8. (8) Carson (3-3)
Roger Jones scored a pair of touchdowns and ran for 93 yards in his return from a shoulder injury, and Kevin McMahon found Darreus Rogers for a 75-yard bomb. Good momentum heading into the one they've all been waiting for. Last week: Beat Banning, 30-9. Next: at Narbonne, Friday.
9. (9) Dorsey (5-1)
Quite a difference from last year as defense keeps proving to be the Dons' strength. They've allowed an average of 11.3 points per game, by far the least among Coliseum League schools. Last week: Beat West Adams, 21-12. Next: vs. Manual Arts at Rancho Cienega Park, Friday.
10. (NR) San Pedro (6-0)
Another game, another blowout for the undefeated Pirates. Senior Kenny Potter is one of the better pro-style quarterbacks in the area. Four of his six completions Friday went for touchdowns. He sat out the entire second half. Last week: Beat Washington, 48-12. Next: vs. Gardena, Friday.
Dropped out: St. Paul (10).
Newcomer: San Pedro.
Ten more, in alphabetic order: Cabrillo (6-1), Covina (6-1), Damien (5-1), Dominguez (4-2), Gahr (5-1), Maranatha (6-0), St. Paul (5-1), San Dimas (5-1), Serra (4-2), West Covina (6-1).
Blair Angulo covers preps for ESPN Los Angeles. Following him on Twitter.


text: It's my time by Chris Edman published on 2012-07-17T00:06:15Z Original song, "It's my time" Hope you like it. Genre Country Comment by Fuchsiaone I love it. Do listen to my stuff. 2012/08/01 10:10:27 +0000 Comment by Chris Edman @tonyslyrics: Thank you Tony, i sure appreciate it. 2012/07/17 23:53:02 +0000 Comment by Tony's Lyrics Nice country lyrics, vocal and playing Chris. 2012/07/17 03:22:27 +0000


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Condition: Standard
All Product Details
The hero of Ragged Dick is a veritable "diamond in the rough"as innately virtuous as he is streetwise and cocky. Immediately popular with young readers, the novel also appealed to parents, who repsonded to its colorful espousal of the Protestant ethic. Struggling Upward, published nearly thirty years later, followed the same time-tested formulas, and despite critical indifference it, too, had mass appeal.
As Carl Bode points out in his introduction, Horatio Alger filled a void in American literature and met scant competition both in the nature and the number of his works. Like his heroes, Alger rose to the top by chance, coincidence, and hard work.


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Hi Cindy---Are you saying that the cause of the spotting on Sea Sprite is
not a virus? Or is it a virus that only affects Sea Sprite?
Hank Zumach
Stoddard, WI
zone 4B
----- Original Message -----
From: <email@example.com>
To: <email@example.com>; <firstname.lastname@example.com>
Cc: <firstname.lastname@example.com>
Sent: Monday, July 10, 2000 1:48 PM
Subject: good news about H. 'Sea Sprite'
> Hi hosta folks,
> I talked to my friend Debbie Nelsen after her 2nd hour long visit with Dr.
> Lockhart. He said that my tiny sample of Sea Sprite was too small to
> but it looks fine to him. He said he's tested MANY of them over the
> and never found any virus. It seems there is alot of hysteria for nothing
> about this plant.
> Cindy Johnson
> White Bear Lake, MN
> zone 4a
> ---------------------------------------------------------------------
> To sign-off this list, send email to email@example.com with the
> message text UNSUBSCRIBE HOSTA-OPEN
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE HOSTA-OPEN


text:
Root Systems (root position voicings)
- Root systems, part 1 / Take three at a time: an approach to learning major scales and ii-V-I progressions in all keys along with tunes from The Real Book (Volume I, sixth edition)
- Root systems, part 2 / outlining the ii-V and ii-V-I progressions with 7-up scales
- Root systems, part 3: Give it up for the root (position pattern)s! – Melodic patterns based on root position voicings
- Root systems, part 4 / Elijah's Bounce
Pairings (jazz and classical pieces)
- Pairings, part one: left-hand walking bass and right hand lines in Dave McKenna, Bach and Handel
- Pairings, part two: left hand walking bass with right hand chordal comping by Kenny Barron, John Coates Jr. and G.F. Handel (or, Spring Comping Trip)
- Pairings, part three – Hand-some conversation: Two-handed melodic conversations by J.S. Bach and Oscar Peterson
The State of The Blues (solos on blues progressions)
- Will The Circle Be Unbroken, Part 1: the seventh scale, the circle of fifths, melodic patterns from rootless dominant 7th voicings (featuring 'October Blues')
- Will The Circle Be Unbroken, Part 2: an exercise and reflections on the circle of descending fifths and the dominant cycle
- 'Making the changes' on the blues
- Rhythm Changes and Trading Fours
- Charlie Parker and Alan Turing: Anthropology is 'The Bombe'
- One half step of separation: Miles Davis and Ray Vega (a.k.a. the half step between the root and the seventh in the seventh scale)
- 'Now What?': a modal melody collage
- 'Ornithology': the memory palace of two bebop masterminds
- Six Degrees of Bud Powell, Part ii-V-I
- What is this scale called: Charlie Parker, Barry Harris and the minor ii-V progression
Conversation Pieces
Comping Trips (examples of comping by great jazz pianists)
Monthly Archives: January 2013
'Making the changes' on the blues
Right now I'm teaching the part of the improvisation class at UVM where we learn Barry Harris' scale outline of the blues and then compose a chorus of solo on this progression. To illustrate how useful this outline can be, … Continue reading
Posted in Uncategorized 2 Comments


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Traditional radio the most popular radio station of the country. Traditional radio is a thematic radio chain that broadcasts different types of hit radio channels all the time all day long. This is one of the most popular of them all as this channel is dedicated to play hip hop songs all time. Radio Traditional official website address is radiotraditional.ro
Please wait for 10-20 seconds Radio is Loading…
Popular Alabama Radio:
88.1 Way FM
CMR Nashville
Lite FM 96.9


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It started out as a game, but they are playing for keeps…
One thought on "Cloak & Dagger Movie Trailer"
This movie is awesome! I remember seeing it as a kid. I also own it in a DVD combo pack with "The Wizard" another great movie from the Golden Age Of Gaming.
Comments are closed.


text:
Air Jordan 3 (III) Joker Black Green Purple 2013
|Air Jordan
|Air Jordan 3 (III)
$145.00 $81.00
|In Stock, shipping in 24 hours. Free Shipping!
First mocked just last month, now we have our first overall look at next years release of the Air Jordan 3 (III) Joker Black Green Purple 2013.At the outset of this year, we is often expected the Bobcats, Cold Grey colorway, this particular brand new and top notch jordan 5 shoes colorway come out in the classic white and black tumbled leather upper, powder bluish colorway hits about the lining and plastic outsole very eyes-catching.We is still welcomed many of good Air Jordan 3 (III) which including Air Jordan 3 (III) and also of great model sneakers, and it is time to look at another weekend's worth of athletic shoes hitting stores.Continue reading to understand the news of the running shoes for Mike after which you'll get a look at the asking price on eBay.


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Launch of Retro Asian Brunch at High Ultra Lounge
Bengaluru folks out there! this weekend get set to be a part of stunning visual delight at High Ultra Lounge, the tallest lounge bar in South India. While you enjoy the breathtaking view of garden city, High Ultra Lounge will be attempting to set a record by creating the longest Domino Trail of shots. The Domino trail will have 421 shots representing the 421 feet height of High Ultra Lounge.
High Ultra Lounge has a surprise planned for the foodies as well. They will launch their Retro Asian Sunday Brunch specially orchestrated by Chef Myo. Mouth watering traditional delicacies will be served while you listen to the golden musical hits of 70's – 80's era.
Not just the food, you can even relive your childhood memories by trying out flying kites at the counter set up by High. Overall a perfect way to enjoy your weekend with your family and friends. Don't miss the golden opportunity. Book your tickets right away….
Food&Beverages: selection:
Special buffet spread by culinary team to mark the launch of this event.
Special Selection of beverages to be offered from ASPRI portfolio
5-6 Live food counters (Tepenyaki, Grills, Sushis, Dim Sums, Rice & Noodles)
421 shooters of jager bomb will be present at High.
Guest DJ / Band / Stand up act to be lined for entertainment.
If you enjoyed this post, please consider to leave a comment or subscribe to the feed and get future articles delivered to your feed reader.


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Smarter. Simpler
Our latest news
Contigo works with Lacima
We are excited to announce our successful work with award-winning energy and commodity analytics specialist, Lacima, to offer a new risk engine embedded in its enTrader® ETRM system.
Lacima is a widely recognised energy and commodity analytics software provider, and this is the first time that the company has embedded part of its risk functionality into an ETRM system. Our new enTrader® Analytics Module calculates Value at Risk (VaR) at any given time, giving risk mangers the information they need to put into place appropriate risk management strategies.
Responding To Energy Market Change
The European power and gas industry is currently going through a period of very rapid change that has potentially far reaching consequences. While change is certainly no stranger to the industry, it requires players in the industry to constantly re-evaluate their business process and technology infrastructures in order to adapt and thrive. This whitepaper explores how...
Risk Associated with Older Technology
Adrian Bullock, Contigo managing director warns that many energy businesses are operating with a higher level of risk than is necessary, because important systems do not use the latest technology.
He likens the situation in some to "driving a Heavy Goods Vehicle down the motorway and only looking out at the road ahead every few hours" and has released a simple check-list to help businesses judge whether their ETRM system is based on modern technology.
Meeting your REMIT Obligations
Under the new REMIT regulation, which came into force on October 7th 2015, energy trading companies and large energy consumers will need to report all standard trades and orders to trade in the European wholesale power and gas markets to ACER, via a RRM (Registered Reporting Mechanism). There are various RRMs available, such as Trayport, EFETNet and RegisTR. "Standard" trades cover those executed on exchanges such as EEX and ICE, and the majority of trades executed electronically through brokers.
You are in good company.
Prior to using enTrader, we had been using spread sheets, and made the decision to move to an ETRM system to improve our energy trading. We chose enTrader because of its ease and speed of implementation, its flexibility and because it offered the best value. Read full case study >>
Mikkel Kynde
Portfolio Manager
We are delighted to be working with Contigo and utilising enTrader and enVoy to evolve our Trading processes. They offer a way for us to remain a cutting edge and flexible arm of a leading energy supplier without the problems and unnecessary complexities of some of the more cumbersome ETRM solutions. Read full case study >>
Ben Gatley
Head of Trading
View all case studies
Find out more about Contigo
Markets and Sectors
Contigo provide both cloud-based and on-site energy trading solutions across generation, wholesale and retail businesses.
About Contigo
Contigo is dedicated to working with its clients to deliver software solutions to all points in the energy value chain.
Meet the Team
The team at Contigo have a strong background in energy utilities and trading, find out about some of them…


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Using animated gif's as product image
Posted 18 July 2012 - 08:25 PM
Due to the nature of our products it is crucial we can display animated gif's as product image.
I know uploaded images are converted to jpg and I think the way to make animation possible is to avoid this conversion. Besides that the pages where the images are displayed have to be modified also of course.
I have been searching the forum for any plugin that does this, but unfortunately I only find answers like 'not possible'. I think that this should be possible with some minor changes, only I don't have the knowledge to write code from scratch. I can do simple modifications though.
Has anyone done this before and succeded?
Posted 18 July 2012 - 08:31 PM
Unfortunately, all product images get converted to jpg format, so they cannot be displayed as animated gifs.
Posted 18 July 2012 - 08:53 PM
Yes, when you don't change the code, gif's are not an option :-)
But according to several web developers, they can fix this for me. The fact that it is not a standard option doesn't mean it is impossible, right? I mean, I am sure that if the community decides this should be implemented, it will be done somehow.
So, do you think that even changing the core code would never make it possible?
Posted 18 July 2012 - 08:56 PM
if also you can get a script to upload gif pictures and store in prestashop system then you can give a try.
that mean you will not use upload pictures from preatshop.
Edited by valentin.g, 18 July 2012 - 08:57 PM.
- wurf likes this
Posted 15 June 2016 - 08:54 AM
You can use the module: http://addons.presta...-gif-image.html
It allows you to upload gif image for product & logo.
Front office demo here: http://demo.globosof...oduct/index.php
Globo is specializing in Prestashop development. Contact to us if you are looking for Prestashop Developer: www.globosoftware.net/prestashop-development-company/
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0 members, 0 guests, 0 anonymous users


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Forum:RC Warbirds and Warplanes
Forum:MarketPlace questions or problem?
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The goal of this project is to develop new diagnostic technology for detection and molecular analysis of cancer cells, especially circulating tumor cells. Our approach will be based on the previously developed DMR (diagnostic magnetic resonance) system that combines a miniaturized NMR probe with targeted magnetic nanoparticles for detection and molecular profiling of cancer cells. The system measures the transverse relaxation rate of water molecules in biological samples in which target cells of interest are labeled with magnetic nanoparticles. In preliminary study, we have detected a few cancer cells in fine needle aspirates, profiled the expression of cellular markers, and measured the pathway inhibition in small numbers of cancer cells. To further advance the DMR technology for molecular and cellular sensing of CTC, we propose three aims: 1) we will synthesize and further develop a new class of magnetic nanoparticles with high magnetic moments and optimize their chemical, biological properties for CTC labeling;2) we will implement a new DMR chip that can separate CTC from whole blood, measure multiple cancer markers in parallel, and sense the magnetic moments of individual cancer cells; 3) we will evaluate the clinical utility of the developed system using human samples, particularly detecting cancers outlined in the RFA (e.g. ovarian cancer, pancreatic cancer, glioma). Technology, materials and processes developed and optimized in this project will also be useful for Project 4 (implantable NMR based sensors), Projects 1 and 2 (targeting cancer cell populations) and Project 5 (novel hybrid nanomaterials).
This proposal aims at optimizing, validating and further developing the most advanced magnetic nanotechnology for cellular analyses. The development and testing of a sensitive, reliable and robust platform for CTC detection, isolation and analysis has the potential to revolutionize cancer prevention and treatment.
|Xiao, Zeyu (2014) CuS nanoparticles: clinically favorable materials for photothermal applications? Nanomedicine (Lond) 9:373-5
|Zheng, Yao-Rong; Suntharalingam, Kogularamanan; Johnstone, Timothy C et al. (2014) Pt(IV) prodrugs designed to bind non-covalently to human serum albumin for drug delivery. J Am Chem Soc 136:8790-8
|Wu, Jun; Kamaly, Nazila; Shi, Jinjun et al. (2014) Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl 53:8975-9
|Eltoukhy, Ahmed A; Sahay, Gaurav; Cunningham, James M et al. (2014) Niemann-Pick C1 affects the gene delivery efficacy of degradable polymeric nanoparticles. ACS Nano 8:7905-13
|Lin, Kevin Y; Lo, Justin H; Consul, Nikita et al. (2014) Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade. ACS Nano 8:8776-85
|Xue, Wen; Chen, Sidi; Yin, Hao et al. (2014) CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature 514:380-4
|Morton, Stephen W; Zhao, Xiaoyong; Quadir, Mohiuddin A et al. (2014) FRET-enabled biological characterization of polymeric micelles. Biomaterials 35:3489-96
|Chen, Ou; Riedemann, Lars; Etoc, Fred et al. (2014) Magneto-fluorescent core-shell supernanoparticles. Nat Commun 5:5093
|Laughney, Ashley M; Kim, Eunha; Sprachman, Melissa M et al. (2014) Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med 6:261ra152
|Liu, Vincent H; Vassiliou, Christophoros C; Imaad, Syed M et al. (2014) Solid MRI contrast agents for long-term, quantitative in vivo oxygen sensing. Proc Natl Acad Sci U S A 111:6588-93
Showing the most recent 10 out of 68 publications


text:
Dayton Signs Tax Break Bill
ST. PAUL, Minn. (AP) — Quickly adopted tax legislation that provides breaks to tens of thousands of Minnesota taxpayers is now law. Governor Mark Dayton signed the bill Saturday when it landed on his desk. …25 Jan 15
Local News, Multimedia, Sports - The Local Connection
Wheeler Dealer
ST. PAUL, Minn. (AP) — Quickly adopted tax legislation that provides breaks to tens of thousands of Minnesota taxpayers is now law. Governor Mark Dayton signed the bill Saturday when it landed on his desk. …25 Jan 15
(Carver, MN) — A Carver County sheriff's deputy was one of two people severely injured after a crash in Carver Thursday night. Deputy Erick Boder of Chaska, a 10-year veteran, was patrolling on Highway 11 …24 Jan 15
Tuesday was the first day income tax returns could be filed, and right on cue, Minnesota's most famous eagles seem to have dropped a little reminder to brighten the perennial chore. Sometime Jan. 20, the …23 Jan 15
NEW ULM, Minn. (AP) — Authorities are investigating after a partially clothed man was found dead in a residential alley in New Ulm. Commander Dave Borchert of the New Ulm Police Department says the body …23 Jan 15
ST. PAUL, MN—In an effort to give school districts greater flexibility in bonding levy decisions, Rep. Glenn Gruenhagen, R-Glencoe, has introduced House File 224 which would give school districts three options when making levy bonding …23 Jan 15
ST. PAUL, Minn. (AP) — A flood aid package meant to assist more than half of Minnesota counties hit with severe flooding cleared the Minnesota Senate on Thursday. By a 65-0 vote, the Senate approved …23 Jan 15
ST. PAUL, Minn. (AP) — Minnesota lawmakers are restarting a two-year-long push to set rules for how law enforcement agencies use automated license plate readers. The cameras are usually mounted on squad cars, logging car …23 Jan 15
ST. PAUL – Minnesota's seasonally adjusted unemployment rate fell to 3.6 percent in December, according to figures released today (Thursday) by the Minnesota Department of Employment and Economic Development (DEED). The U.S. unemployment rate was 5.6 …22 Jan 15
Check out our Sports Broadcast Schedule! From the Twins, Wild, and Vikings to your local High Schools or Amateur Baseball teams, we've got you covered right here!


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Yes, yes, a thousand times yes. That's our response to Ricky Gervais claiming the producers of the Golden Globes asked him to consider another year hosting. He posted that on his blog in the above photo (bottom right-hand corner). Click here for a bigger version.
Ricky writes, "I did exactly what I went to do. Improve on last year's and have a laugh. The response was staggering. It was discussed on every news channel and chat show for weeks … I have yet to find anyone who was actually offended by it. The ratings went up again, and the organisers asked me to consider a third year. I don't think I should. I don't know what I could do better. I certainly couldn't get more press for them, that's for sure. You know me. Two seasons is enough."
A Golden Globes rep denies there is any truth to Ricky's claim.
Other highlights from his Golden Globes Week blog:
Friday, Jan. 14: "Had dinner with Larry David … Michelle Pfeiffer was in the restaurant and shouted over, 'Don't say anything horrible about me tomorrow!' As if I would say anything horrible about Hollywood icons."
Sunday, Jan. 16: "Just had time to work out and lunch before we had to get ready for the Globes. I love putting on a tuxedo in 80-degree heat at 2 pm in the afternoon, then walking down the red carpet, waving. Still, at least with the few pounds I've lost, I don't sweat as much."
We think Ricky did a bang-up job and we'd welcome him at the 2012 Golden Globes. What do you think?


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School of Music
Application for Music Entrance and AwardIn addition to applying for admission to WIU, student who wish to major or minor in music are required to audition prior to registering for their music courses. Please contact Trista Trone, (309) 298-1087 or email firstname.lastname@example.com, to schedule an on campus audition or submit an audition online through ACCEPTD. Instructions Please go to Online Form Submission
**** Student still needs to email in three letters of recommendation forms to School of Music and should be recieved before your audtion date. **** If you still have question, please call Trista Trone, Recruitment Coordinator, at (309) 298-1087 or email firstname.lastname@example.com for the application form.


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Amare Stoudemire's older brother, Hazell, lived a more troubled life than the Knicks power forward. He had spent time in prison and was arrested 22 times since 1993, according to the Polk County Sheriff's website.
But to Stoudemire, Hazell, who passed away in a car crash last week, was always "Big STAT." According to a source, he "always looked up to Hazell, regardless of whether he was in prison or not -- that was his guy." At Hazell's funeral on Saturday, Stoudemire's family said it was the first time he had cried since he was 12.
Now that visible pain will stay with "Little STAT" for the rest of his life. Stoudemire got a teardrop tattoo on Monday right below his right eye, in memory of his older bro.
"The tear tattoo shows I'm still crying inside," he said, according to the New York Post. "It's hard to explain how close my brother was to me. He was my father figure and mentor and why I played basketball. He's part of my success so I'm always crying inside."
Stoudemire has always been an emotional player on the court and Tuesday night in Toronto, he showed some of that flair in the second half, after looking rusty in the first. No one can imagine what was going through his mind, his first game back after his brother's death, but STAT was able to feed off his teammates' energy and play better.
Stoudemire was 2-for-9 from the field heading into halftime, but finished with 21 points and nine rebounds, including a key basket with 2:39 remaining to cut the Knicks' deficit to 86-82, after they trailed by 17 points.
A lot of talk before the game surrounded how Stoudemire would play with Jeremy Lin in the pick-and-roll, and they had a few Steve Nash-like connections. Lin's ability to draw the defense in by quickly penetrating the open seams (like a Pro Bowl running back) and weaving through the paint while still maintaining his dribble enabled Stoudemire to free up on the block and get gimme looks at the rim -- just like he had in Phoenix.
Stoudemire and Lin showed chemistry as the Raptors game progressed, and Stoudemire finished 5-for-10 from the field off Lin's passes (3-for-12 in all other situations). Stoudemire's results, based on Lin's play, were typical for the rest of the team, as they struggled to generate their own offense.
Knicks' Offense Tuesday Against Raptors
Off Lin's Passes | All Others*
Field goals -- 11-for-23 | 13-for-37
Field goal percentage -- 47.8 | 35.1
Effective field goal percentage -- 52.2 | 37.8
Points -- 24 | 28
*Not including Lin's numbers or free throws
Stoudemire and Lin were especially effective using the pick-and-roll, a strategy the big man had not used much this season. Entering Tuesday, Stoudemire was averaging only one field goal attempt per game when using the P&R offense, and he averaged a half-point more per play against the Raptors than he had all season.
Stoudemire In Pick-And-Roll Offense
First 22 Games | Tuesday
Field goals -- 11-for-22 | 3-for-5
Field goal percentage -- 50.0 | 60.0
Points per play -- 1.0 | 1.5
Points per game -- 1.3 | 9.0
Source: ESPN Stats & Info
You can follow Jared Zwerling on Twitter.
Information from ESPNNewYork.com's Ian Begley was used in this report.


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- 06-29-2014, 12:10 AM Thread Author #1
Charging issues
I have a galaxy s4 active... not sure for how long now but it has been working fine until today. a few times it didnt like the charger i had used so i switched the charger and it would begin charging asap, the next day i would use the one issued to me and it would work fine again. Anyway, this morning it said for 4 hours that i needed to unplug it from the charger because it was at 100% (although it was unplugged). Then i restarted it and it began working fine. i tried to plug it in before leaving the house and it gave me a notification like, "usb connected" or something of the sorts. it died and i now have it plugged into my laptop but it has a battery icon with a frozen loading symbol... i really need it for work but i am unable to turn it on. any suggestions?
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Re: Charging issues
Welcome to Android Central! The USB port of your computer providers a fairly weak current, so I would plug it into a wall outlet and let it sit for a good 10-12 hours undisturbed. Then try turning it on again.
If it still give you problems, then it may be a battery issue. You could consider trying a new battery.
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Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice
DOI: 10.1186/ar3019
© Toyama et al.; licensee BioMed Central Ltd. 2010
Received: 30 November 2009
Accepted: 18 May 2010
Published: 18 May 2010
Targeting joint destruction induced by osteoclasts (OCs) is critical for management of patients with rheumatoid arthritis (RA). Since phosphoinositide 3-kinase (PI3-K) plays a critical role in osteoclastogenesis and bone resorption, we examined the effects of ZSTK474, a novel phosphoinositide 3-kinase (PI3-K)-specific inhibitor, on murine OCs in vitro and in vivo.
The inhibitory effect of ZSTK474 on OC formation was determined and compared with other PI3-K inhibitors by counting tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells after culturing murine bone marrow monocytic OC precursors, and RAW264.7 cells. Activation of Akt and expression of nuclear factor of activated T cells (NFAT) c1 in cultured RAW264.7 cells were examined. The suppressing effect of ZSTK474 on bone resorption was assessed by the pit formation assay. The in vivo effects of ZSTK474 were studied in collagen-induced arthritis (CIA) in the mouse. Oral daily administration of ZSTK474 was started either when more than half or when all mice developed arthritis. Effects of ZSTK474 were evaluated using the arthritis score and histological score of the hind paws.
ZSTK474 inhibited the differentiation of bone marrow OC precursors and RAW264.7 cells in a dose-dependent manner. The inhibitory effect of ZSTK474 was much stronger than that of LY294002, the most commonly used PI3-K inhibitor. In addition, ZSTK474 suppressed the bone resorbing activity of mature OCs. Moreover, oral daily administration of ZSTK474, even when begun after the development of arthritis, ameliorated CIA in mice without apparent toxicity. Histological examination of the hind paw demonstrated noticeable reduction of inflammation and of cartilage destruction in ZSTK474-treated mice. ZSTK474 also significantly decreased OC formation adjacent to the tarsal bone of the hind paw.
These findings suggest that inhibition of PI3-K with ZSTK474 may potentially suppress synovial inflammation and bone destruction in patients with RA.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the synovium as well as by destruction of inflamed joints through bone erosion. The management of patients with RA consists of both reduction of inflammation and protection of the joints from structural damage [1]. Some anti-rheumatic drugs, including biologics, are quite useful but are not effective in all patients; hence, new therapeutic agents are required.
It has been speculated that joint destruction is directly caused by osteoclasts (OCs) [2], which differentiate from monocytic precursors that have infiltrated the inflamed joints. After this infiltration, monocytic precursors convert to tartrate -resistant acid phosphatase (TRAP)-positive cells and fuse with each other, eventually forming giant multinucleated OCs. Although the growth and differentiation of OCs mainly depend on receptor activator of nuclear factor κB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, which are over-expressed in the inflamed joints, promote this process [3]. After differentiation, ανβ3 integrins on differentiated OCs engage with the bone extracellular matrix; this process is followed by bone resorption [4, 5]. It has been demonstrated that this increased resorbing activity of OCs results not only in bone erosion and further joint destruction but also in systemic osteoporosis in patients with RA. Therefore, suppressing OCs is a major aspect of RA therapy [6, 7].
Signal transduction via the phosphoinositide 3-kinase (PI3-K)/Akt pathway is essential for regulating cellular responses, such as proliferation, survival, migration, motility and tumorigenesis, in a variety of cell types [8], not just OCs. Class I PI3-Ks are heterodimers and are found in four isoforms. Class IA PI3-Ks (PI3-Kα, PI3-Kβ and PI3-Kδ) are composed of a catalytic subunit p110 (α, β, or δ) and a regulatory subunit p85 (α or β), and activated through tyrosine kinase signaling. The class IB PI3-K (PI3-Kγ) is a heterodimer consisting of a catalytic subunit p110γ associated with one of two regulatory subunits, p101 and p84, and activated via seven-transmembrane G-protein-coupled receptors (GPCRs) [9]. Whereas the expression of PI3-Kα and PI3-Kβ is ubiquitous, that of PI3-Kδ and PI3-Kγ is mainly restricted to hematopoietic cells [8].
Many signal transduction molecules are involved in different phases of growth and development in OCs, such as Src homology-2 (SH2)-containing inositol-5-phosphatase (SHIP), Vav3, Gab2, extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) [10–14]. In OCs, PI3-K is a major downstream effecter of the M-CSF receptor, RANK, and αβν3 integrin. The importance of PI3-K for differentiation, survival and motility of OCs has been demonstrated by using the PI3-K inhibitors wortmannin and LY294002 [15–22], and also by studying mice deficient in the expression of the p85α subunit of class IA PI3-K [23]. In addition, several transcription factors, including NF-kB, c-fos, AP-1, PU.1, and CREB, are involved in regulating osteoclastogenesis in its early or late phase, and expression of NFATc1 is specific to the RANKL induced-signaling pathway and essential for terminal differentiation of OCs [24, 25].
Wortmannin and LY294002, potent inhibitors of PI3-K that have been extensively used for studying ex vivo PI3-K-driven signal pathways, also inhibit other related enzymes [9, 26]. LY294002 causes severe dermal toxicity [27], and wortmannin and its analog has shown hepatic toxicity [28] when administered in mice. ZSTK474, a synthesized s-triazine derivative that strongly inhibited the growth of tumor cells, was subsequently identified as a novel PI3-K-specific inhibitor [29–33]. Furthermore, ZSTK474 is suitable for oral administration, and demonstrated marked in vivo antitumor activity in mice grafted with human cancer cells without showing toxicity to major organs [29].
Since the action of ZSTK474 on OCs is unknown, we examined the effects of ZSTK474 in an in vitro OC culture system and found strong inhibitory effects on the differentiation and bone resorbing activity of OCs. Moreover, daily administration of ZSTK474 ameliorated collagen-induced arthritis (CIA) in mice, remarkably reducing the migration of inflammatory cells and OCs in the synovial tissue.
Materials and methods
PI3-K inhibitors
ZSTK474 and IC87114 (a PI3-Kδ-selective inhibitor) were synthesized at Central Research Laboratories of Zenyaku Kogyo Co. Ltd. (Tokyo Japan). LY294002 was purchased from Sigma Chemical Co. (St Louis, MO, USA). AS605240 (a PI3-Kδ-selective inhibitor) was purchased from Calbiochem (Schwalbach, Germany). In in vivo experiments, ZSTK474 was prepared as a solid dispersion [34].
Male DBA/1 mice (eight weeks old) were purchased from Charles River Laboratories Japan (Kanagawa, Japan). They were maintained at approximately 22°C with a 12-hour light/dark cycle and given standard chow and tap water ad libitum. Newborn ddY mice were obtained from the Japan SLC, Inc. (Shizuoka, Japan). All animal experiments were approved by the local ethical committees of each institution.
Osteloclast formation
In vitro OC formation was examined as previously described [35]. Briefly, primary osteoblasts derived from growing calvarial cells of newborn ddY mice at three- to four-days of age were suspended in alpha-minimum essential medium (α-MEM, Sigma) supplemented with 10% (v/v) fetal bovine serum (FBS, Gibco BRL, Gaithersburg, MD, USA), 100 U/ml penicillin and 100 μg/ml streptomycin, and plated at a density of 2 × 104 cells/well in 24-well plates (Corning Incorporated, Corning, NY, USA) overnight. Mouse bone marrow cells containing monocytic OC precursors were removed aseptically from the tibiae of four- to six-week old ddY male mice, and co-cultured on adherent osteoblasts at a density of 1.0 × 106cells/well in medium containing 10-7 M 1α,25-(OH)2D3 (Wako Pure Chemical Industries, Ltd., Osaka, Japan) for five to six days in the presence or absence of varying concentrations of ZSTK474 or other PI3-K inhibitors. Otherwise, non-adherent bone marrow cells were cultured alone with 10 ng/ml of M-CSF (R & D Systems, Minneapolis, MN, USA) for two days, and then adherent cells were cultured with 100 ng/ml of soluble RANKL (sRANKL) (R & D Systems) for three days. In some experiments, RAW264.7 cells (American Type Culture Collection, Manassas, VA, USA) were plated at a density of 2.5 × 104 cells/well in a 24-well tissue culture plate overnight, and sRANKL (100 ng/ml), TNF-α (50 ng/ml) and ZSTK474 were added. The medium was changed every two to three days. The cells were fixed with 3.7% formalin, permeabilized with 0.1% Triton X-100, and stained with TRAP. OC formation was determined by counting TRAP-positive multinucleated cells having three or more nuclei, and OCs were counted in each set of duplicated wells.
Real time-polymerase chain reaction (PCR) for the quantification of RANKL expression
The osteoblasts were plated at a density of 2 × 105 cells/well in six-well plates, and cultured with or without 1α,25-(OH)2D3 for 24 hours in the presence or absence of ZSTK474. Total RNA was extracted using a total RNA isolation kit (Ambion Inc., Austin. TX, USA), and 3 μg of the total RNA was reverse transcribed using a You-prime Fast-Strand Breads kit (Amersham Pharmacia Biotech, Inc., Piscataway, NJ, USA). The primers used in PCR were 5'-GACTCGACTCTGGAGAGT-3' (sense primer) and 5'-GAGAACTTGGGATTTTGATGC-3' (antisense primer) for RANKL and 5'-AGCCATGTACGTAGCCATCC (sense primer) and 3'-CTCTCAGCTGTGGTGGTGAA (antisense primer) for β-actin. Real-time PCR was performed using 1 μg of cDNA and Power SYBR Green Master Mix (Applied Bio Systems, Foster City, CA, USA) on an ABI PRISM 7500 Sequence Detection System (Applied Bio Systems) with conditions at 95°C for 10 minutes, followed by 40 cycles at 95°C for 15 seconds and 60°C for one minute. The expression of RANKL was quantified using the comparative CT, applying the formula Xn = 2-ΔCT, where Xn is the relative amount of target gene in question and ΔCT is the difference between the CT of the house keeping gene for a given sample [36].
Western blotting for Akt and NFATc1
RAW264.7 cells were plated at a density of 2.5 × 105 cells/well in a six-well tissue culture plate overnight, and ZSTK474 was added. After incubation for 30 minutes, 50 to 100 ng/ml of sRANKL, or sRANKL plus TNF-α (50 ng/ml), was added and the cells were incubated for the indicated time. Cells were washed twice with ice-cold phosphate-buffered saline (PBS) containing 1% phosphatase inhibitor cocktail (Sigma), detached with a cell scraper, centrifuged, and lysed with lysis buffer (1% Triton X-100, 1% phosphatase inhibitor cocktail and 1 mM of PMSF in Tris-buffer, pH 7.6). The lysates were boiled with sodium dodecyl sulfate (SDS) -sample buffer and run on SDS-PAGE followed by blotting with a 1:1000 dilution of anti-phospholylated Akt (anti-phospho Akt), anti-Akt, anti-IκB, anti-phospho cJun, anti-phospho p42/p44, anti-β-actin (Cell Signal Technology, Inc., Beverly, MA, USA) and anti-NFAT1c monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA).
Immunofluorescence microscopy
RAW264.7 cells (200 μl, 2.5 × 105/ml) were plated onto Lab Tek Chamber slide (Thermo Fisher Scientific, Rochester, NY, USA) overnight. After treatment with 0.1 μM of ZSTK474 for 30 minutes, 100 ng/ml of sRANKL and 50 mg/ml of TNF-α were added, and the cells were cultured for 48 hours. Then, the cells were fixed with 4% paraformaldehyde, washed with PBS three times, permeabilized with 0.1% Triton X-100 in PBS, and blocked with 10% normal goat serum (Nichrei, Tokyo, Japan). The cells were incubated with anti-NFATc1 antibody diluted in PBS (1:50) for one hour, washed with PBS, and followed with phycoerythrin-conjugated goat anti-rabbit IgM+IgG (H+L chain specific, Beckman Coulter) for another one hour. The cells were postfixed in Aqua-Poly/Mount (Polysciences, Washington, PA, USA) and viewed using fluorescence microscope (Nikon ECLIPSE E600/Y-FL).
Bone resorbing activity of OC
A 10 cm culture dish (Corning) was coated with 5 ml of type I collagen mixture at 4°C. The dish was placed in a CO2 incubator at 37°C for 10 minutes to render the aqueous type I collagen gelatinous. Primary osteoblasts (5 × 105 cells/dish) and bone marrow cells (6 × 106 cells/dish) were co-cultured on the collagen gel-coated dish for five days. The dish was then treated with 4 ml of 0.2% collagenase solution (Nitta Gelatin Co., Osaka, Japan) for 20 minutes at 37°C in a shaking water bath (60 cycles/minute). The cells were collected by centrifugation at 600 rpm for three minutes, then washed and suspended with α-MEM containing 10% FBS (OC preparation). Dentine slices (Immunodiagnostic Systems, Ltd., Boldon, UK) were cleaned by ultrasonication in distilled water, sterilized using 70% ethanol, dried under ultraviolet light, and placed in 96-well plates. A 0.1-ml aliquot of the OC preparation was transferred onto the slices. After incubation for 72 hours in the presence or absence of the PI3-K inhibitors, the medium was removed and 1 ml of 1 M NH4OH was added to each well and incubated for 30 minutes. The dentin slices were then cleaned by ultrasonication, stained with hematoxylin (Wako Pure Chemical Industries) for 35 to 45 seconds, and washed with distilled water. The area of resorption pits that formed on dentine slices was observed under a light microscope and measured.
CIA in mice
Male DBA/1 mice, eight-weeks of age, were injected intradermally in the base of the tail with 200 μg of bovine type II collagen (Collagen Gijutsu Kenshu-Kai., Tokyo, Japan) emulsified in complete Freund's adjuvant (Difco, Detroit, MI, USA) on Day 1, and the same amount of the antigen emulsified in incomplete Freund's adjuvant (Difco) on Day 22. When half of the mice had developed arthritis (Day 28), the mice were randomly divided into four groups of eight mice. Each group orally received vehicle or 25, 50, 100 mg/kg of ZSTK474, once/day. In another therapeutic protocol, 100 mg/kg of ZSTK474 was administered from the day when all mice developed arthritis (Day 31). Total arthritis score was defined as the sum of the paw swelling scores for each paw (0 to 4 per paw), with a maximum score of 16. In the semi-therapeutic protocol, the mice were killed on Day 50, and the right hind paws were removed, fixed in paraformaldehyde, decalcified in Kalkitox (Wako Pure Chemical Industries, Ltd.), embedded in paraffin and sectioned. The sections were then stained with hematoxylin and eosin (H&E) or safranin O to assess hyperplasia of synovial tissue, infiltration of leukocytes, and destruction of cartilage. Each parameter was graded separately and assigned a severity score as follows: grade 0, no detectable change: 1 to 4, slight to severe changes. The number of OC in talus was counted in every third 6 μm section. To examine in vivo OC formation in CIA mice, the hind paws were removed on Day 52 and rapidly frozen in the therapeutic protocol. The frozen tissue was sectioned according to the method described previously [37] and the sections were stained with H&E or TRAP. Plasma TRACP5b levels were measured using a mouse TRAP™ Assay (Immunodiagnostic System Ltd).
Statistical analysis
Statistical significance of differences was assessed by one-way analysis of variance (ANOVA) followed by Dunnett's test or the Student's t-test for comparison of two samples. Statistical tests were performed using Kaleida graph 3.6 (Synergy Software, Reading, PA, USA). In all analyses, P < 0.05 was considered statistically significant.
Inhibitory effects of ZSTK474 on OC formation in co-culture system
Inhibition of Akt phosphorylation and NFATc1 expression in RAW264.7 cells by ZSTK474
Inhibitory effects of ZSTK474 on OC formation induced by both RANKL and TNF-α
We next examined the effects of ZSTK474 on OC formation induced by RANKL and TNF-α, since it was speculated that TNF-α enhanced OC formation in RA. In fact, RANKL-induced phosphorylation of Akt was enhanced by the addition of TNF-α (Figure 2d). ZSTK474 (0.03, 0.1, and 0.3 μM) inhibited the phosphorylation of Akt induced by RANKL (100 ng/ml) and TNF-α (50 ng/ml) in RAW264.7 cells (Figure 2d). Moreover, the OC formation induced by RANKL (100 ng/ml) and TNF-α (50 ng/ml) was inhibited by ZSTK474 in a dose-dependent manner. OC formation was completely inhibited by ZSTK474 (0.3 μM, Figure 2e).
Inhibition of bone resorbing activity of OC by ZSTK474
Amelioration of CIA in mice with oral administration of ZSTK474
Histological score and osteoclast number
Vehicle (n = 6)
2.3 ± 0.8
1.7 ± 0.9
2.7 ± 0.6
62.0 ± 38.6
(n = 6, 50 mg/kg)
0.0 ± 0.0
0.0 ± 0.0
0.8 ± 0.3
0.3 ± 0.2
In this study, we demonstrated that ZSTK474, a novel PI3-K-specific inhibitor, suppressed osteoclastogenesis and bone resorption. The in vitro inhibitory effect of ZSTK474 on OC formation, observed by culturing bone marrow cells, was much stronger than that of LY294002. Although both inhibit all isoforms of class I PI3-K, the inhibitory activities of ZSTK474 (IC50: PI3-Kα: 1.6 × 10-8 M; PI3-Kβ: 4.4 × 10-8 M; PI3-Kγ: 4.9 × 10-8 M; PI3-Kδ: 4.6 × 10-9 M) were much stronger than those of LY294002 (IC50: PI3-Kα: 5.5 × 10-7 M; PI3-Kβ: 1.1 × 10-5 M; PI3-Kγ: 1.2 × 10-5 M; PI3-Kδ: 1.6 × 10-6 M) on all isoforms, especially PI3-Kδ [30]. A PI3-Kδ-selective inhibitor, IC87114 (1 μM), completely inhibited OC formation, while a PI3-Kγ-selective inhibitor, AS605240, had no inhibitory effect on OC formation. These results indicate the involvement of PI3-Kδ in the OC culture system, consistent with a previous report which implicated a critical role of class IA PI3-K in OC formation by demonstrating that OC progenitor cells from mice lacking p85α, a regulatory subunit of class IA PI3-K, showed impaired growth and differentiation [23].
Blocking of the phosphorylation of Akt by ZSTK474 in RAW264.7 cells indicated that the inhibitory effect on OC formation observed in the bone marrow monocytic cells was due at least in part to suppression of PI3-K/Akt signal pathway in the OC precursors. This suggestion is supported by the observation that the consequent expression of NFATc1, an essential factor for terminal RANKL-induced differentiation of OCs [25, 38], was also prevented by ZSTK474. The reduced expression of NFATc1 was dependent on neither NFkB nor cFos in the condition of this study. Additionally, translocation of NFATc1 into the nucleus was also inhibited by ZSTK474, implying that ZSTK474 might suppress the autoamplification, calcium-signal-mediated persistent activation [40], of NFATc1. Moreover, ZSTK474 inhibited the phosphorylation of Akt and OC differentiation induced by both RANKL and TNF-α, which are fundamental factors for OC formation in RA, implying that ZSTK474 might inhibit OC formation in patients with RA.
ZSTK474 also suppressed the bone resorbing activity of OCs as assessed in an in vitro pit formation assay. This could be explained by the inhibitory effect of ZSTK474 on survival of mature OCs in part. Likewise, signaling via PI3-K is crucial for remodeling and assembly of actin filaments, cell spreading and adhesion [41]. Furthermore, blocking PI3-K with ZSTK474 inhibited the membrane ruffling induced by platelet-derived growth factor (PDGF) in murine embryonic fibroblasts [29]. In OCs, the SH3 domain of tyrosine kinase, c-src, interacts with the p85 regulatory domain of PI3-K, and this signaling pathway is crucial for colony-stimulating factor-1-induced OC spreading [22]. Therefore, ZSTK474 might suppress the cytoskeletal change of OCs, resulting in the reduced bone resorption observed in this study.
ZSTK474 suppressed inflammation and also protected against joint destruction in CIA in mice. Although it is difficult to ascertain the direct effect of ZSTK474 on OCs in this model, the TRAP-staining of the synovial tissue sections demonstrated marked reduction of OC formation. In addition, plasma levels of TRACP5b, that reported to correspond with systemic but not localized bone resorption [42], were not increased in 100 mg/kg ZSTK474-treated mice. This result implied that 100 mg/kg of ZSTK474 possibly prevented the systemic bone resorption.
Both the semi-therapeutic and therapeutic treatments of ZSTK474 ameliorated joint inflammation in a mouse model of RA. This anti-rheumatic effect might be explained by contribution of PI3-K to activation, proliferation and migration of inflammatory cells, such as lymphocytes, macrophages, neutrophils, mast cells and synovial fibroblasts [9]. However, the titers of antibody to type II collagen were not significantly different between vehicle- and ZSTK474-treated mice in this experiment (data not shown). Regarding migration, chemokine receptors, such as the MCP-1 receptor and the RANTES receptor, are GPCRs that associate with PI3-Kγ and induce signals for chemotaxis of the inflammatory cells [9]. It was reported that the PI3-Kγ-selective inhibitor suppressed joint inflammation in mouse CIA by inhibiting migration of neutrophils to the joints [43]. This inhibitory process might occur in the ZSTK474-treated mice. Additionally, synovial pannus tissues of patients with RA express phosphorylated Akt [44] and exhibit tumor-like behaviors, such as angiogenesis, proliferation and invasion. A recent report demonstrated potent antiangiogenic activity for ZSTK474, which could be attributed to both inhibition of VEGF secretion by cancer cells and inhibition of PI3-K in endothelial cells [45]. These findings also account for the effects of ZSTK474 on CIA mice. In addition, ZSTK474 did not affect the count of peripheral white blood cells and red blood cells (data not shown). Further studies are underway to evaluate how ZSTK474 exerts anti-inflammatory activity in vivo.
Clinical studies have demonstrated that the degree of inflammation and the progression of joint destruction do not always correspond with each other [46, 47]. In current therapy for RA, anti-rheumatic drugs are required not only to control the inflammation but also to suppress the joint destruction. On the other hand, recent reports have shown convincing pathogenic evidence for the involvement of class I PI3-K and Akt signaling pathways in synovial fibroblasts [44, 48–52] and other cells [43, 53, 54] in patients with RA. Synovial tissue from patients with RA expressed higher levels of phosphorylated Akt than that from patients with osteoarthritis [44]. Moreover, blocking the PI3-K/Akt pathway by intracellular gene transfer of phosphatate and tensin homolog deleted on chromosome 10 (PTEN), which dephosphorylates phosphatidylinositol - 3,4,5 - tris - phosphate (Ptdlns(3,4,5)P3) and attenuates the downstream signals of PI3-K, CIA in rats [52]. Taken together, the present results indicate that PI3-K could be a potent target for RA therapy.
We have demonstrated inhibitory effects of ZSTK474 on in vitro OC formations and CIA in mice. Inhibition of PI3-K with ZSTK474 may potentially have an anti-rheumatic effect in patients with RA.
collagen-induced arthritis
extracellular signal-regulated kinase
fetal bovine serum
- GCPRs:
G-protein-coupled receptors
mitogen-activated protein kinase
macrophage-colony stimulating factor
- NFATc1:
nuclear factor of activated T cells c1
- OCs:
platelet-derived growth factor
phosphoinositide 3-kinase
phosphatate and tensin homolog deleted chromosome 10
rheumatoid arthritis
receptor activator of nuclear factor κB
RANK ligand
Src homology-2 (SH2)-containing inositol-5-phosphatase
tumor necrosis factor
tartrate-resistant acid phosphatase
- α-MEM:
alpha-minimum essential medium
We thank Asako Sasaki (Central Research Laboratory, Zenyaku Kogyo Co., Ltd, Tokyo, Japan) and Naoki Ishihara (Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan) for technical support. We also owe thanks to Shin-ichi Yaguchi (Zenyaku Kogyo Co., Ltd) who gave insightful comments and Makoto Fukae and Shinichiro Oida (Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan) who supported the set up of the in vitro experiments.
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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I've always thought that matching certain headphones with certain headphone brands is such a silly thing... like matching the Grados with rock music. which rock music are we talking about? which guiter player? which guitar? which fuzz pedal? which producer? etc... the number of soundings are simply countless.
i think you meant "certain brands with certain types of music". and i totally agree. as soon as someone starts saying "brand x is good for classical and terrible for rock" or whatever, i start to lose respect. especially when people start to get really ridiculous and try to specify the "type" of rock music. "These are good for prog but not metal". Or "those are good for metal from 1982-1999, but terrible for metal after 1999." I mean, c'mon. This is getting into Monty Python absurdity territory.


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On the second day of the school year, Superintendent Cindy Marten let me tag along with her on a visit to San Diego High School.
It was still early in the day, just after 10, and already the classrooms were stifling. Marten was there for a school visit. So while she shadowed her area superintendent, who in turn shadowed the school principals, my plan was to shadow Marten.
As we dipped in and out of classrooms, sweat dripped onto my notebook and bled my writing. The air was thick and smelled like a musty gym shirt. I spent only a few minutes at a time in classrooms. I didn't want to imagine what it was like for kids or teachers who cook in those hotboxes for an entire day.
On the one hand, weather is about the most clichéd thing to ever grumble about. On the other, lack of air conditioning in classrooms raises serious concerns for health and the ethical treatment of kids.


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Results 1 to 5 of 5
- 07-31-2014, 10:06 AM Thread Author #1
Apps won't install
Since yesterday my S5 would not install any app I downloaded. I tried to install a new app from the Play Store: it would download, but then nothing happens...
I tried updating a app via Play Store: same thing.
I downloaded the Amazon App Shop-App, the APK is saved on my device, but when I tap on it to install it, nothing happens...
What kind of sorcery is this?
- Posts
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Re: Apps won't install
Make sure the Download Manager isn't disabled somehow. Go to the App Manager, select Download Manager, and select Enable if it's disabled.
Since it isn't installing the Amazon Appstore apk, I assume this isn't an isolated Google Play Store issue. You might want to try booting into Recovery and wiping the system cache partition: Reset: Samsung Galaxy S 5 | T-Mobile Support
- 07-31-2014, 02:06 PM Thread Author #3
Re: Apps won't install
Thank you so much!!!
The wipe helped.
- Posts
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Re: Apps won't install
No, wiping the cache partition won't erase any personal data.
- 10-06-2014, 09:10 AM Thread Author #5
Re: Apps won't install
Wiping the Cache solved the problem!
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ACEII - CORE D. The UCLA CART Research Training and Education Core offers an unprecedented opportunity to create a new kind of autism research scientist by unifying education and training in neurosciences and genetics and infusing the psycho-behavioral perspective across the full spectrum of research, from the bench to social science. Notably, since its inception as an NIH Autism Center in 2003, the UCLA Center for Autism Research and Treatment (CART) took the lead to design and develop training, education and community outreach as a key component of its center. With this ACE Center renewal, CART will continue its already established special programs (including Pilot Grants, Annual Symposium, and Affinity Lecture series) and also will institute a formal research training program. The Core D Training Program will oversee the identification, selection, recruitment and training of qualified and highly motivated predoctoral students and postdoctoral fellows (Sigman Scholars). In addition, each of the trainees will be partnered with a CART faculty member who will guide his or her training and development and will ensure that the trainee is incorporated into the larger CART interdisciplinary autism research agenda. The program has five Specific Aims: 1) Develop new interdisciplinary training initiatives in autism research;2) Establish a Los Angeles community-wide infrastructure to optimize outreach and cross-disciplinary training and to facilitate the recruitment of research subjects and the dissemination of scientific findings;3) Build upon existing autism training activities by expanding the scope to include mentoring and other curricular elements;4) Establish policies, criteria and processes for selecting students and fellows;and 5) Implement and evaluate the programs. Our goal is to develop the training pathway in interdisciplinary autism research from undergraduate student to graduate student (pre-doctoral) to postdoctoral fellow (Sigman Scholar) to junior faculty in order to leverage the expertise and experiences of the senior investigators of the UCLA CART to train the next generation of autism researchers.
Given the complex nature of Autism Spectrum Disorders, an interdisciplinary approach to training autism researchers is necessary. The goal of the Research Training and Education Core for this ACE grant is to provide scientific information to the public and interdisciplinary training by senior experts at UCLA to produce the next generation of autism researchers who will address the needs of children with ASD and their families.
|Brenner, Laurie A; Shih, Vivian H; Colich, Natalie L et al. (2015) Time reproduction performance is associated with age and working memory in high-functioning youth with autism spectrum disorder. Autism Res 8:29-37
|Jann, Kay; Gee, Dylan G; Kilroy, Emily et al. (2015) Functional connectivity in BOLD and CBF data: similarity and reliability of resting brain networks. Neuroimage 106:111-22
|Del Rosario, Mithi; Gillespie-Lynch, Kristen; Johnson, Scott et al. (2014) Parent-reported temperament trajectories among infant siblings of children with autism. J Autism Dev Disord 44:381-93
|Alaerts, Kaat; Woolley, Daniel G; Steyaert, Jean et al. (2014) Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism. Soc Cogn Affect Neurosci 9:1589-600
|Gaugler, Trent; Klei, Lambertus; Sanders, Stephan J et al. (2014) Most genetic risk for autism resides with common variation. Nat Genet 46:881-5
|Di Martino, A; Yan, C-G; Li, Q et al. (2014) The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism. Mol Psychiatry 19:659-67
|Zwaigenbaum, Lonnie; Young, Gregory S; Stone, Wendy L et al. (2014) Early head growth in infants at risk of autism: a baby siblings research consortium study. J Am Acad Child Adolesc Psychiatry 53:1053-62
|Schneider, Maude; Debbané, Martin; Bassett, Anne S et al. (2014) Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome. Am J Psychiatry 171:627-39
|Tak, Sungho; Wang, Danny J J; Polimeni, Jonathan R et al. (2014) Dynamic and static contributions of the cerebrovasculature to the resting-state BOLD signal. Neuroimage 84:672-80
|Mullen, Brian R; Khialeeva, Elvira; Hoffman, Daniel B et al. (2013) Decreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology. ASN Neuro 5:e00106
Showing the most recent 10 out of 41 publications


text: We're sorry, Astor Flower Crystal Necklace is no longer available Why not try one of these instead? Design Your Own Star Necklace by J&S Jewellery £19.50$33.46€23.37$24.98 free UK delivery Triple Letter Disc Necklace by J&S Jewellery £16$27.45€19.17$20.50 free UK delivery Maya Stone Heart Personalised Silver Necklace by Bloom Boutique £14$24.02€16.77$17.93 free UK delivery Caitlan Personalised Leaf Pendant Necklace by Bloom Boutique £19$32.60€22.77$24.34 free UK delivery Pinch to zoom Astor Flower Crystal Necklace by Kiki's £18$30.89€21.57$23.06 This item is no longer available Favourite Favourite View your favourites we're sorry we're sorry, This item is no longer available buy a gift voucher related categories jewellery > women's jewellery > necklaces & pendants by Kiki's Location: Derby, GB read seller's profile see seller's complete range more items from this seller Silver Plated Swallow Earrings by Kiki's £12$20.59€14.38$15.37 Kappa Wooden Eco Watch by Kiki's £110$188.78€131.83$140.95 Jupiter Wooden Eco Watch by Kiki's £99$169.90€118.65$126.85 Vintage Style Camera Watch Pendant Necklace by Kiki's £16$27.45€19.17$20.50 Inspirational Friendship Wish Bracelets by Kiki's £3.95$6.77€4.73$5.06 Arm Candy Bag Of Tricks Vanity Case by Kiki's £12$20.59€14.38$15.37 view all you may also like PRODUCT DETAILS DELIVERY RETURNS gift wrapping available ask seller a question save for later A beautiful Astor flower inspired crystal necklace. Gorgeous Aster flower pendant design with Swarovski Crystals and pearls. The finish gives a certain vintage feel, with a sparkle of special Swarovski crystal in the centre of the heart and surrounding the Astor flower. A lovely piece of jewellery. Matching bracelet and stud earrings available. Every piece comes beautifully boxed. made from: Crystal and plated brass. dimensions: Length: 40cm to 45cm with adjuster. product code: 221043 This product is dispatched to you by Kiki's. You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Kiki's's return policy Please see notonthehighstreet.com's returns policy.


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Talk:Tonga Fifita
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Baddest Man In Wrestling[edit]
Uliuli Fifita was known as the toughest wrestler of his era. There are many accounts in interviews that give a detailed description of some of these fights. He himself tells of the amazing story of taken on 5 guys at once plus bouncers of the bar. In which he was charged and had a trial which he was sued for 2.5 millin dollars. He seems like a truly genuine person in this interview and very legitimate. In interviews with other wrestlers they all name Fifita as the toughest. http://www.wrestlingobserver.com/wo/news/interviews/default.asp?aID=17490
Bad News Brown states that Haku was the tougest backstage fighter without a doubt http://www.wrestlingobserver.com/wo/news/headlines/default.asp?aID=15770 Cashisclay 20:29, 10 October 2006 (UTC)
Requesting page move[edit]
It is well known among Fifita's friends and family, that he rarely uses his middle name Uliuli, and is more commonly known by his first name, Tonga. A page move to Tonga Fifita would be more appropriate. IMDB has already made a correction for Fifita's listing on their site. It would be nice if Wikipedia followed suit. Thanks! T5806 00:58, 24 January 2007 (UTC)
I think the body of the text could be organized better chronologically. There seems to be bits of data that have been inserted into the article and don't fit into the flow of the text and could be moved elsewhere in the article. Barkeep Chat | $ 22:09, 20 February 2008 (UTC)
Requested move[edit]
- The following discussion is an archived discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review. No further edits should be made to this section.
The result of the move request was: not moved Armbrust The Homunculus 13:22, 17 September 2013 (UTC)
Tonga Fifita → Haku (wrestler) – Per WP:COMMONNAME. He was Haku a lot longer than he was Meng. Therefore, this is the common name for him. GeicoHen (talk) 01:46, 8 September 2013 (UTC) Oppose A bit more common, but it's not like Meng wasn't also quite common. King/Prince Tonga is clearly third, but also worth considering. InedibleHulk (talk) 12:27, September 8, 2013 (UTC)
- Oppose Meng, King Haku, Haku, Prince Tonga... a lot of names, I don't know the common name. --HHH Pedrigree (talk) 12:34, 8 September 2013 (UTC)
- Oppose, I don't think this is clearly the common name. McPhail (talk) 17:28, 8 September 2013 (UTC)
- Oppose He wrestled under a number of names. Meng and (King) Haku stand out, but I'm not sure if either outshines the other enough to be considered his common name.LM2000 (talk) 19:59, 8 September 2013 (UTC)
- The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page or in a move review. No further edits should be made to this section.
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Religious School and Hebrew School at Shir Tikvah
Join our schools community at Shir Tikvah! With around 200 students in Religious School, 80 students in Hebrew School, and over 25 teachers and tutors, life for young people at Shir Tikvah is both fun and meaningful for all ages.
For download:
Please contact Forrest Yesnes, Youth Director, with questions about Religious or Hebrew School. email@example.com or 612.822.1440
Opportunities for young people abound at Shir Tikvah, from the littlest tots to graduating high school seniors.
Newborns to pre-Kindergarten: Join us for Tot Shabbat, the first Saturday morning of every month, for an engaging and family-friendly, musical service with Rabbi Latz, Rabbi Rappaport, and Shana Eisenberg
Pre-Kindergarten: Sign up for the bi-monthly Mishpacha (family) class
Kindergarten to 10th grade: Sign up for weekly Religious School, Sundays 9:30am to 11:30am
3rd grade to 7th grade: Sign up for weekly Hebrew School, Wednesdays 4:30pm to 6:30pm or 6pm to 8pm
Post B'nei Mitzvah: Ready to come back and support your favorite past teachers and classes? Volunteer or get paid to mentor younger students and assist teachers as part of the Ozrim (8th to 12th) or Madrichim (11th and 12th) program
6th grade to 8th grade: JYG - Get a taste of youth group with monthly social and learning events hosted by the senior youth group, STiFTY
9th grade to 12th grade: STiFTY - Gather for both monthly local STiFTY events and quarterly regional/national NFTY events. Visit www.northern.NFTY.org for more information
Religious School and Hebrew School Registration
1) Download the PDF above, fill it out, print, and mail/scan to Forrest at 5000 Girard Ave S Minneapolis, MN 55419 or firstname.lastname@example.com
2) Complete the registration online by clicking the link, saving it to your computer, filling out the information on all pages, saving again, and sending to Forrest at firstname.lastname@example.com
Make your school payment here. Use Shir Tikvah's GiveMN page to make your school payment. Just note what it's for and we'll take it from there. Keep in mind there is scholarship available for any youth program - no family will be turned away from the quality Jewish education and community we offer here. Contact John Humleker, Executive Director, at firstname.lastname@example.com or 612.822.1440


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Ronan is Professor of Public Health at Swansea University. He is a public health physician/epidemiologist with 30 years experience of clinical medicine, public health and health informatics in Ireland and the UK, and has a particular interest in the prevention, treatment and rehabilitation of injuries.
Research profile: see www.researcherid.com and type in ResearcherID: G-7741-2012


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Dance Clubs Winnipeg, MB
51 results for Dance Clubs in Winnipeg, MB
- Magic 'N Motion Studio Manitoba, 1-1333 Niakwa Road EastR2J 3T5 Winnipeg, MB 204-254-8419Closed
dance education and passion for dance to our students by providing quality training in technique and artistry through one on one attention and instruction by qualified and passionate teachers. We...
- Zoloto Ukrainian Dance Ensemble & Company Manitoba, Po Box 28028 1795 Henderson HwyR2G 4E9 Winnipeg, MB 204-942-6268
..., costumes, and music. Under the Artistic Direction of its founder, Keris Matskiw, Zoloto established their own dance school and became known as the Zoloto Ukrainian Dance Ensemble & Company in 1994.
- Request for QuotationAre you looking for Dance Clubs & Halls ?Use our "Request for Quotation" service to get customized offers from companies in Winnipeg, MB, tailored for your exact needs!
- Zumba Dance Fitness with Karla Manitoba, 565 Guilbaut St.R2J 0R2 Winnipeg, MB +1 204-880-2048
Zumba is not only great for the body, but its also great for your mind and soul, improves self-esteem, self confidence and self-image! Without a doubt, Zumba is the best workout party in the world!...
- InnerEdge Manitoba, 1737 Portage AvenueR3J 0E5 Winnipeg, MB 204.837.7061
Dance, you will find fine quality high performance competitive and practice wear in a complete size range from children's to adult. Motionwear and Mondor are premier providers of active apparel for...
Results from similar categories
- Studio One School Of Performing Arts Manitoba, One-160 Murray Park RoadR3J 3X5 Winnipeg, MB STURGEON CREEK (204) 831-0111Open
Ballet, Jazz, Hip Hop, Musical Theatre, Modern, Tap, Pre-School, Ages 3 - Adult ... Dance Clubs, drama schools, écoles de danse, Public Schools, Club, Art Schools
- Rumors Comedy Club Manitoba, 190-2025 CorydonR3P 0N5 Winnipeg, MB (204) 488-4522Open
... Artistes et Amuseurs, Rumor s Comedy Club, dance clubs, Rumor's Restaurant & Comedy Club,...
- Marquis Dance Academy Manitoba, 20 ISLAND SHORE BLVDR3X 1N6 Winnipeg, MB ISLAND LAKES (204) 255-8486Closed
... Instruction, Club, Sports individuels, Dance Clubs, Danse-Studios, Sports et Loisirs
- Kids Etcs Youth Movement Company Manitoba, 3525 Unit H Roblin BlvdR3R 0C6 Winnipeg, MB VIALOUX (204) 896-5172
dance programs in ballet, jazz, hip hop, tap, lyrical, modern, musical theater and pre-school programs. Our faculty is a milieu of talented and caring people, each with the primary mandate of...
- Romanetz Ukrainian Dance Ensemble MB, STREETR2C 0A1 Winnipeg, MB MELROSE (204) 582-1249
... Dance Clubs, Club
- Patricias Dance Studio & Swing Club MB, 297 NAIRN AVENUER2L 0W8 Winnipeg, MB CHALMERS (204) 667-0990
... écoles, danse, Dance Clubs
- Ecole de Danse Classique Incorporated MB, 20 ISLAND SHORE BLVDR3X 1N6 Winnipeg, MB ISLAND LAKES (204) 255-8486
... Instruction, Dance, Dance Clubs, Club
- Mr Roberts-The Place To Dance MB, STREETR2C 0A1 Winnipeg, MB MELROSE (204) 338-8433
... Dance Clubs, Club
- Monicas Danz Gym Manitoba, 1325 MARKHAM RDR3T 4J6 Winnipeg, MB WAVERLEY HEIGHTS (204) 261-8890
... Dance Clubs, Club
- Masterworks Studio Manitoba, 77 HENDERSON HIGHWAYR2L 1L1 Winnipeg, MB (204) 946-5617
... Club, Dance, Instruction, Dance Clubs
- Ukrainian Dance Works Manitoba, 176 SUTHERLAND AVENUER2W 3E4 Winnipeg, MB NORTH POINT DOUGLAS (204) 942-6268
... Dance Clubs, Club
- Royal Dance Conservatory Manitoba, 1 FORKS MARKET RDR3C 4L9 Winnipeg, MB THE FORKS (204) 943-4978
... Sportswear Retail, Club, Dance Clubs
- School Of Contemporary Dancers Manitoba, 109 PULFORD STREETR3L 1X8 Winnipeg, MB RIVER - OSBORNE (204) 452-1239
... écoles, Club, danse, Dance Clubs
- Backstreet Boutique Manitoba, 3525 ROBLIN BOULEVARDR3R 0C6 Winnipeg, MB VIALOUX (204) 896-5172
... Dance Clubs, Supls, clothes supplies dance exercise, Dance, supplies dance, Sportswear Retail,...
- Scandals Fun Club High n-r-G Dance Club MB, 1792 PEMBINA HIGHWAYR3T 2G2 Winnipeg, MB FORT GARRY (204) 474-2582
... Night Clubs, Hotels, Motels
- Montys Sports Bar Dance Club MB, 2280 PEMBINA HIGHWAYR3T 2H3 Winnipeg, MB MONTCALM (204) 261-4808
... Room, Night Clubs, Beverage Rooms, Drinking Places
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text:
pk11obj.c:1143:4: warning: "/*" within comment
pk11obj.c:1152:17: warning: "/*" within comment
pk11obj.c:1162:7: warning: "/*" within comment
could this please be addressed? i know it's sample code, but perhaps
#undef SAMPLE_CODE
#ifdef SAMPLE_CODE
would be better, then the code would be recognized by syntax highlighters, the /* embedded in the code */ would be treated as a comment and the compiler would not complain about it.
Timeless, is this a coverity bug?
i didn't tag it as such, i have to presume it isn't. the syntax of the output here implies i was using gcc i believe.
Created attachment 241149 [details] [diff] [review]
replace outer comments w/ #if 0 block and make sure {}s match
this bug is something i see whenever i build on boffo, because the build process hangs (for a relatively long time) while signing the nss library. as a result, i'm likely to see this annoying warning and want to file a bug about it. or today, post a patch :).
Comment on attachment 241149 [details] [diff] [review]
replace outer comments w/ #if 0 block and make sure {}s match
r=nelson for the trunk (only), provided the patch still applies cleanly.
firstname.lastname@example.com: i don't have commit privs (which is fairly annoying on its own given that i do touch the whole tree and play nicely by rules), would you please commit?
On trunk
new revision: 1.17; previous revision: 1.16


text:
Registration is now open for 2017!
Registration extended! Places still available!
Please visit the "Register" page.
We require a minimum of 20 campers so please spread the word!
Next Camp With Wings will be on the following dates:
January 15th – 22nd 2017
Welcome to the Camp with Wings website with all of the information you will need to learn about camp and how it works, how to register, and become part of the ever-growing Camp with Wings family. For one week in January every year, we join together from all corners of Australia and, indeed, sometimes the world, and connect and share, learn and create, grow and fly with newly forged friendships and stimulated imaginations running free.
Camp with Wings aims to give home-educated, unschooled teens the opportunity to connect and grow in a safe, like-minded community, to make new friends and develop independence. Camp also aims to support teenagers in their choice of education without having to choose school to meet their needs for companionship and the growing teen challenges.
The next camp will be our 12th Camp with Wings. Please join us for lots of fun and laughter and inspiration at our favourite campsite of the four we have attended over the years, Lions Camp Duckadang, on the headwaters of the Brisbane River, about 2 hours north of Toowoomba. www.duckadang.com.au
T-shirt competition!
We also organise an annual camp t-shirt design competition every year. Guidelines for design are fairly simple, single colour design (as they are screen printed) reflecting what camp means to you, with the words Camp with Wings 2017 included somewhere. Although we will not be choosing the design or printing the t-shirts until November, you can submit your entries (as many as you like) anytime you have the inspiration.
Home Education Association inc.