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1 hour payday loans by telephone- Hard cash support right away
Actuel loans if you have a bad credit background
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× View Today's Deals
You missed it This great deal for Salon XQuisite is over. But don't despair, we've got more great deals every day.
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Goshen Crossing Shopping Center
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subset: commoncrawl


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Thousands upon Thousands American citizens on Medicare Part A and Part B are are now finding that with the right Medigap Coverage they can:
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Preserve your health and assure your assets with a Medicare Supplement Insurance Policy
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Thankfully, it doesn't have to be. Locating a Medicare Supplemental Agency that you can trust is a cinch when you realize that:
Obtain a Medicare Supplement Insurance Policy through our company and get peace of mind about both your affordable premiums and the up to 100% protection.
However that is not everything our company will do. Have you ever tried before to register for an insurance plan like a Medicare Supplement Insurance? Thousands and thousands of people 65 years of age and older are lamentably denied coverage or received limited coverage on their plan that they were blind sided by only after they had taken care of the first premium. Additionally way too often there can be stressful hassles involved in getting a refund or procuring another suitable Medicare Supplement Insurance Coverage or other coverage.
We're too good at what we do to let this happen to you. The Medigap Agents on staff are also skillful "field underwriters.†So we shall not only aid you in discovering the lowest for Medicare Supplement Quotes, but we shall ensure you do meet the requirements for the coverage we go forward with any paperwork. With a few quick questions about your health, you could immediatley approved for Medicare Supplement Plans that should approve you the first time, with no hassles or fears of revoking plans.
Our agents don't counsel a specific plan for you until we know for certain that you qualify for approval by the insurance company Moreover, our Lowest Rate Guarantee means that you not ever have to pay a cent because of our services and are always making payments the economical available cost on the suggested plan you qualify for.
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Why We Recommend Medicare Supplement Plan F
Medigap is an insider term applied to health care plans commonly known as Medicare Supplement Insurance. Medigap Plans cover the gaps in Medicare coverage that aren't taken care of by Medicare Parts A and B.
A Medigap Plan is not an substitute for Original Medicare like a Medicare Advantage Plan, but instead works with Original Medicare. Moreover, Medigap Plans are different from Medicare Advantage Plans because they have no co-pays, no deductibles, and no issues with being "in nework" as to where you can receive medical treatment..
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Medigap Policies: How they give you freedom
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With a comparison that is easily done on our website of Medicare Insurance Plans, you can see the one that is right for your health and your budget and then you won't have to worry about extra medical expenses ever again.. This is worth repeating, if you decide on a Medicare Supplemental Plan F from us, you won't ever receive a leftover healthcare expenses to pay.
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Like hundreds of thousands of Americans on Medicare that we have helped down through the years, you have figured out that attempting reach the decision on a Medicare Insurance Policies is usually annoying and enough to make you lose sleep over it.. Also, attempting to acquire a Medicare Supplemental Insurance Carrier that will help out as you assess Medicare Supplemental Plans is trying as well.
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What is more, you never pay for our services.
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If you are on Medicare, you're doubtlessly dealing with crucial decisions on selecting a great Medicare Supplement Policy and you're doubtlessly duped by Medicare Advantage salespeople.
Medicare Supplemental Policy Providers are mandated to give each customer idententical coverage options coverage options. So this is why it's so very, very important to shop Medigap Policy Rates from top companies with a partner that is on your side.
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What is more that is not all we are capable of for you. Have you ever tried apply for a policy like a Medigap Policy? A lot of patients, are often denied coverage or received restrictions on their policy that they didn't see coming after they'd taken care of the first premium. There is often enormous hassles in receiving the money you put down for the first premium or locating another Medicare Insurance Rate or other plans.
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The Medicare Supplement Policy Brokers on our team are also Medicare Supplement Policy Field Underwriters. This means we'll not only assist you to find the least expensive Medicare Supplemental Quotes, we will also make sure that be qualified for the policy before we walk you through the approval process. Simply by answering fast questions about the status of your health, you can be instantly signed up for a Medicare Supplement Insurance Plan take you you the first time, without problems or concerns about of denied claims for lack of coverage.
We won't suggest a Medicare Supplemental Insurance Policy for you unless we know you qualify to be approved by the Medicare Supplemental Insurance Policy company. Morever, our Cheapest Monthly Premium Promise ensures that you never pay a dime for our professional and that you will always pay the cheapest available rate for the recommended plan you are qualified for.
To make this easy, we made arrangements with all the big Medigap Carriers to let you apply for coverage over your phone quickly. You will receive the most affordable Medicare Supplement available, a policy for as long as you keep up with your premiums and, if you select a Medicare Supplement Plan F, you will not ever pay extra money again for Medicare eligible Medicare eligible.


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Demojo PLT
Food, Event Management Services, Event Management
MEM started in 1998 and till today has served more than thousand major corporations, hotels, societies and private clients. We are based in KL & Penang. We specialized in corporate function such as annual dinner, conference & launching, family day, team building, telematch, holiday tour & travel, entertainment, sound & light, premium & gift, logistic arrangement, etc.
We provide 1 stop solution for your family day from equipment rental, canopy set up, sound & light to live entertainment & games activities. MEM would guaranteed you a extraordinary family day!
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Did you ever experience a Samba Carnival in a shopping mall?
Yes, we turn Gurney Paragon into a Samba celebration site!
We brought lots of performances to the crowd included dances,stilt walker, Latin percussion, etc. The highlight was the special appearance of international artiste Soo Wincci as guest performers!
We drew a big crowd & manage to get big sales figure only on the Grand Opening day.
Check out more in our FB: https://www.facebook.com/MultimediaEventManagement?ref=hl
Tired of inflatable on ground?
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Call us for the WATER SPORT INFLATABLE!
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We have more than thousands of premium & gift available to customized based on your request. Our premium & gift ranging from IT product, shirts, umbrella, daily utilities, trophy, etc. These can be given out as souvenir or gift to client or co workers.
MEM had organized more than thousands of telematch for major corporations. We provide you a fun & exciting experience which enhance the bonding among co-worker, family members, etc. Telematch could be a break for your meeting, training, family day, annual dinner, etc. Telematch will definitely bond everyone together in just a minute time!
MEM are associate of licensed tour & travel agency registered under MTCM. Whether you are looking for inbound tour or outbound tour for your company trip, we have it all from hotel arrangement, travel itinerary to logistic arrangement. We have been servicing the major corporation on their company trip for more than 16 years! MEM promised you a professional & satisfying service from us.
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We offer you a hustle free & wonderful annual dinner!
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>General Running>7 minute mile lesson
I suprised, no shocked myself at my last 10k race! don't know where it came from but I do know that I was thinking I'd run the race and then do another 4 miles for my long run that day but I was tossed. spent. done. that was all I had. it was a great feeling.
Needs more cowbell!
WTG! don't know if that's how you're supposed to do it but, that's hot. I'd take the 2 miles and tuck it away in your brain to remind yourself, you can do it.
• Keep doing stuff.
The voice of mile 18
Tri Rule #1 of Triathlon Training/Racing - If Momma ain't happy nobody is happy


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More Videos...
2011 FORD SHO HOLE SHOT vs gray GTR 10sec.
I hole shot 2 GTR THAT NIGHT. This one ran a 10.859 I ran 1.93 in 60' after that for 8sec more I eat GTR SMOKE LOL
2011 SHO world's fastest (tune only) vs 5.0 kona blu MUSTANG
12.669sec fastest time of the night. The OLD LADY mist that run but got my 12.741sec, 12.744sec,and 12.739sec. All faster than BEEFCAKE's world's fastest 2010 ford Taurus @ 12.79sec. (tune only). There are faster SHO but they other MODs like METH INJECTION, CATLESS DOWNPIPES. Sorry for the bad video(OLD LADY good glad bad video)
SHO vs 6.0 GTO
244FWHP Taurus SHO vs Tuned 6.0 GTO
Boss 302 Vs. Taurus SHO


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It looks like you're new here. If you want to get involved, click one of these buttons!
"Hi, i think that i have a grate opportunity for you, you can get 6 months free in WoW. if you are interested plese do contact me via e-mail (email@example.com) this opportunity is provided by GFK.
MMORPG.COM - Your headquarters for massive multiplayer online role-playing games!
Get your free @mmorpg.com e-mail address today! http://www.mmorpg.com
Oh that's just funny. I don't know what to take offense to more. Seeing a spammer fill my mail box up with useless trash or getting an invite to play *shiver* World of Warcraft again. No thanks, that game is dead to me. Anyways, watch out for these guys. They've got a grate opportunity (sounds painful).


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With Instructables you can share what you make with the world, and tap into an ever-growing community of creative experts.
There may be nothing worse than a great Asian dinner with an inadequate pair of chop sticks. The solution is to take your own, but if you do ...
Large soda bottle Clear tape Epoxy
Harvest a nice rectangle of clear plastic from the bottle. Also harvest 2 threaded tops, cut them off with a hack saw so you just have the threaded ...
Take the rectangle and cut it so when you roll it you get a tube of 1 plus layers and a bit longer than you chopsticks. Roll it ...
You should be able to figure out the use yourself, but keep in mind that both caps must be on for secure confinement. Different size bottles, and different ...
5 New life hacks by MadScienceHacks
101+ Life Hacks Using Chopsticksby Meglymoo87
How to Use Chopsticksby selenanicole
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Tasty Pizza and Pasta (Andiamo Ristorante) - Closed
Brooklyn, NY 11214
- Sun-Thu 11:45am-10pm, Fri-Sat 11:45am-11:30pm
- $
- Dinner, Lunch
- No Parking
- Reservations Accepted, Reservations Not Necessary
Get the Things to Do Newsletter
Sign up for our weekly guide to events in New York, and never be bored again. With suggestions for every day of the week, our recommendations will keep you busy on any budget.
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Fathered By Flagels
Tuesday, March 25, 2003 at 3 a.m. by Robert Sietsema
In the beginning there was Tasty Bagel, founded in 1983 by two brothers from Bensonhurst. The next year they invented the big wheel bagel, a behemoth dough ring piled high with Italian cold cuts and butchered into 26 sandwiches. A d...
More Italian Restaurants in New York
Queens' favorite banquet hall is a stone cave decorated with cherubs and other Roman statuary, ma...Italian
The founders hail from Ponza-where Circe turned Odysseus's men into pigs-50 kilometers south of R...Italian
The titular Waldy is Waldy Malouf, celebrity chef at midtown's Beacon, and this is his entry in t...Italian
Find refined southern Italian cooking at A Voce ("Word of Mouth"), just off the northeast corner ...Italian
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OMG, you hve to b a u.s. citizen b 4 your 18th birthday. CHANGE THE RULE USGA
- Top-5 Mike Malaska Golf Instructional Videos on YouTube
- Mike Malaska Has Launched a New Website: MalaskaGolf.com
- New Scotty Cameron Putters Hit the Market in 2017; Newport and Futura [PHOTOS]
- 5 Reasons Why Vietnam Should be At the Top of Your Golf Bucket List
- 5 Videos Explaining Ben Hogan Secrets That Changed His Career
- Steurer & Jacoby: Wonderfully Made, Premium, Hand-Crafted Golf Bags
- The Bryson DeChambeau Putting Style Has the Golf World Shaking Collective Head
- The GX-7 Metal: GX7Golf.com for More "Consistency?"
- This Story with Jon Rahm Should Give You Golfing Perspective
- Phil Mickelson Short Game Videos: Gold Nuggets on YouTube
Carl Pettersson Is Not Eligible For the Ryder Cup, Although Someone May Want to Tell Him This Kind of Important Fact First. #Awkward
- Updated: August 17, 2012
Carl Pettersson was born in Sweden, played his high school and college golf in the States and a self-proclaimed loves to eat ice cream at night. That latter part is funny and true, but has nothing to do with Carl's Ryder Cup chances; however, the first two scoops do.
According to European Tour officials, because Carl is not a Tour member, he is not allowed to play in the Ryder Cup matches. Carl actually hasn't played a European Tour event since 2006 and hasn't played a full schedule across the pond since 2002, so beyond ice cream it's clear where his loyalty lies (red, white and blue). PGA of America officials recently looked into Carl's status as a potential U.S. team member, but according to rule, the player must have become a U.S. citizen before their 18th birthday, and Carl just became a citizen in January. He also tickled a leaf recently at the PGA Championship and was penalized.
With the Ryder Cup quickly approaching, someone may want to remind Carl of all of this, as Carl apparently doesn't know that he isn't eligible for the matches. To see this in motion, check out Golf Channel's Todd Lewis's interview with Carl below, as Todd basically labels Carl as a drifter without a home country and tells him that even though he's been playing some great golf of late, he's not eligible for the Ryder Cup. Carl then replies saying that he's frustrated, but that if he plays well these next couple weeks he "might get a pick." A big fat awkward sandwich anyone?
Well, there's always the Presidents Cup.
Joel Harrington
9 Comments
Get a grip Carl
What do you expect from someone who uses a long putter.
Another case of living in the US and not a corfirmed citizen until a few months ago?? Change the rules, h–ll no let Carl read the rules and abide by them. I get tired of seeing his name on the scoreboard and a foreign flag beside it. If you want our money and our education get with the program. Sorry set this one out and make a decision who you want to support.


text: This 110-Inch Monster Is the World's Largest Ultra HDTVJamie Condliffe12/30/13 4:30amFiled to: tvssamsungud hdtv274EditPromoteShare to KinjaToggle Conversation toolsGo to permalink At last year's Consumer Electronics Show, Samsung unveiled the world's largest 4K TV. But its paltry 85-inch size is now dwarfed by a bigger brother, which offers up 110 inches of screen real estate. This things is crazy big. Indeed, Samsung promised a larger version of the TV almost a year ago now, and true to its word it goes on sale today. At least, in China, the Middle East and a few European countries at first, until it starts to roll out across the rest of the world next year. Still, it might be worth the wait. Measuring 2.6-meters by 1.8-meters, it's bigger than a king size bed and should be even more incredible to look at than the 85-inch version. It will, of course, cost you. While official pricing isn't yet available, its more modest sibling cost $40,000 new, so you can bet that this one will be a chunk of change more. It may, however, be worth seeing what's announced at CES next week before stumping up any cash. And, you know, buying a TV you can actually fit into your house instead. [Engadget]Reply27 repliesLeave a reply


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IPod Classic Stories May 12, 2016
IPod Classic Stories July 15, 2015
IPod Classic Stories December 10, 2014
Apple kept making the iPod Classic for much longer than many expected, but when it finally called time over lack of components there were still plenty of people who wanted one. The Guardian reports that some iPod Classics are now selling for up to four times the original price.
Versions of the 160GB Classic – which can hold around 40,000 songs – are being sold as new via Amazon for up to £670. More than 3,000 of the models – the seventh, final version came out in 2010 – have been sold on eBay since the Classic was retired in October, most for between £350 and £500. Even refurbished older models now cost far more than the £229 for which the later generations retailed.
While The Guardian was looking at UK prices, the same phenomenon can be seen in the US on Amazon and eBay … expand full story
IPod Classic Stories October 27, 2014
Tim Cook: iPod classic was discontinued due to unavailability of parts, engineering a new version wasn't worth it
Apple CEO Tim Cook clarified the recent decision to quietly remove the iPod classic from sale earlier this year during a talk tonight at Wall Street Journal's WSJD Live conference. According to the executive, some parts needed to manufacture the device were no longer available, and the cost of engineering a new version that didn't require those parts wasn't worth the effort due to low user demand.
The device vanished without a mention from Apple's website last month following a redesign of the company's website immediately after the iPhone 6 debut. It was the last device Apple still sold that used the "legacy" 30-pin connector, while all other iPod models have moved onto the Lightning connector.
IPod Classic Stories September 22, 2014
IPod Classic Stories September 6, 2013
The iPod Classic is the gadget that refuses to die. Despite containing a hard drive when everything else is flash memory and physical controls when everything else is touchscreen, this 2009 device which isn't a trillion miles removed from the original iPod design of 2001 remains on sale on the Apple Store to this day.
But not for long, according to Wired. The piece pulls together a whole bunch of commentators who all agree that this will be the year that Apple retires the elderly design. Perhaps they are right, but we can recall a certain rumor-phobe website called for the death of the iPod Classic as far back as 2011:
Specifically, if you want to buy an iPod shuffle or iPod classic from Apple, you should do it sooner rather than later. We've heard those two iPods are getting the axe this year [2011].
Ars Technica is also feeling an end to the iPod touch this time.


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EA SPORTS FIFA Soccer 13 on PS Vita gives you the same physics-based, data driven technology that powers FIFA gameplay on PlayStation 3.
Take part in eight different game modes, including 11 vs. 11, Tournament Mode with over 50 real-world competitions, a full in-depth Career Mode, and head-to-head online.
Innovations that utilize a rear touch pad and touchscreen create an intelligent and unique gameplay experience. Rear touch pad shooting delivers pin-point accuracy and removes the element of "hit and hope" from shooting and touchscreen passing opens up the field of play for more creative and precision passing.
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360 Presentation Skills
By: Karisfined Edge Solutions
Lagos State, Nigeria
Jun 24 - 24 Jun, 2016
In today's business world, staff and management are expected more and more to present to an audience of some kind of authority and poise. Why is it that certain speeches and presentations last forever in our memories while others fade into oblivion by the time they are finished? Is it the topic, the speaker or the material used? Do you want to learn or improve on your presentation skills?
This training course is designed to develop the skills necessary to deliver confident, thought provoking and meaningful presentations that influence and inspire your audience.
Target Audience
- All those who wish to improve their presentation skills to a noticeable level using a strictly hands-on approach.
- The course is suitable for Trainers, Speakers and people who have to conduct Sales, Business Development or Periodic Presentations to Senior Management.
- 4 Inevitable Mindset for Presentation
- PowerPoint is not the Content
- Reasons for Presentation failure
- Effective Presentation Attributes
- Importance of Preparation
- Pitfalls of Presentations
- How to give a Powerful Opening
- Body Language Dynamics
- Presentation Structure
- Visual aids and Style of Usage
- Answer questions
- Impact of Verbs
- Understand the Impact of Story Telling
- Insight to Powerful Closing
|Citrus Training Centre, Anthony Village, Lagos Mainland
Attendance Fee:
|Experienced Corporate Trainer, Certified Performance Coach and Top-notch Speaker
|Discount is Available for registration of two slots and above. Special discount available for Youth Corpers
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Following up on their preview of Summer headwear, New York-based DQM unveil a selection of t-shirts from their new seasonal lineup. The tees feature simple graphic designs in a wide assortment of Summer-friendly colorways. A release is scheduled for this Thursday June 11th at Dave's Quality Meat.


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Adidas - Greece Feature
Athens and Mykonos campaign shoot in May 2011 with Dennis Busenitz, Silas Baxter-Neal, Lucas Puig, Tim O'Connor, Pete Eldridge, Benny Fairfax, Nestor Judkins, Lem Villemin and Jake Donnelly. Produced and Directed by: Juice Design. Edited by Dan Wolfe, fimed by Dan Wolfe and Torsten Frank.
Caribou - Odessa
Added by renatodonadei to clips 15.09.2011
|Adidas x Official - Miles Silvas and Rodrigo TX
Added 19.10.2016
|adidas Skateboarding Lucas Puig Redux
Added 05.07.2016
|Globe Demo - Athens, Greece
Added 02.06.2016
|adidas "Far & Away" episode 10
Added 01.06.2016
|adidas "Far & Away" Episode 9
Added 01.06.2016


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In other words, despite our occasional bursts of outrage over abusive police practices, sporadic calls for government reform, and periodic bouts of awareness that all is not what it seems, the police state continues to march steadily onward.
Read Whole Story
It's a story so awful that even though my job involves constantly reading news about drug war atrocities, I avoided this one for days.
The war on drugs is out of control. How do we know this? Look no further than the disturbing story that just broke about a New Mexican resident whose routine traffic stop turned into a 14-hour living nightmare.
While the literal purpose of the amendment is to protect our property and our bodies from unwarranted government intrusion, the moral intention behind it is to protect our human dignity.
Four Milwaukee police officers face multiple felony counts for allegedly performing numerous illegal body cavity searches on suspects over the past t...
Seven Milwaukee police officers and one supervisor have had their guns and badges taken away amid allegations that they conducted illegal cavity searc...
How soon before we add body cavity searches to the casual molestations in our pre flight check- lists -- precipitating few outcries even when the airlines try to make some extra coin by piggy backing prostate exams?
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Ham Macaroni Bake
|Elbow macaroni
|8 Ounce (1 Package)
|1 Small, grated
|3 Tablespoon
|All purpose flour
|2 Tablespoon
|Dry mustard
|1 Teaspoon
|1 Dash
|2 Cup (32 tbs)
|Sliced cheddar cheese
|8 Ounce (1 Package)
|Cubed cooked ham
|2 Cup (32 tbs)
|Cherry tomatoes
|1⁄4 Cup (4 tbs)
1. Cook macaroni, drain and keep hot for Step 4.
2. While macaroni cooks, saute onion until soft in 2 tablespoons of butter or margarine in a medium-size skillet. Stir in flour, mustard and pepper; cook, stirring constantly, just until bubbly.
3. Stir in milk; continue cooking and stirring until sauce thickens and bubbles 3 minutes. Cut up half of the cheese slices; add to sauce, stirring until cheese is melted. Cut remaining cheese slices into 6 strips each.
4. Combine drained macaroni and ham in a buttered, shallow, 8-cup baking dish; pour the cheese sauce over; arrange cheese strips, spoke-fashion, on top.
5. Bake in moderate oven (350°) for 30 minutes, or until bubbly-hot.
6. While casserole bakes, saute cherry tomatoes in reserved 1 tablespoon butter or margarine in a medium-size skillet 3 minutes, or just until the skins start to pop; mound on baked casserole just before serving.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 2526 Calories from Fat 1157
% Daily Value*
Total Fat 131 g201.8%
Saturated Fat 79.5 g397.4%
Trans Fat 0 g
Cholesterol 380.1 mg126.7%
Sodium 1630.9 mg68%
Total Carbohydrates 232 g77.4%
Dietary Fiber 11.4 g45.8%
Sugars 40.2 g
Protein 105 g209.3%
Vitamin A 84.3% Vitamin C 31.7%
Calcium 220.1% Iron 41.3%
*Based on a 2000 Calorie diet


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Arabic Made Easy is a simple and uncomplicated Arabic language course for beginner and intermediate Arabic students. The material is presented in a manner that makes learning the language easy. The beginner student can study the book on their own without the need of a tutor. Repetition of difficult grammar items makes learning difficult grammar less daunting.
Supplement 10: Using the Arabic to English Dictionary
There are many types of Arabic to English dictionaries available. Some are simple and concise. They contain fewer words than the more complex ones, but they are equally useful for the beginner student. One such dictionary is:
Al-Mawrid Al Qareeb الْمَوْرِد الْقَرِيْب Arabic – English Pocket Dictionary
In this and similar dictionaries you can search for verbs and nouns. To search for verbs, you need to look for the root form of the verb, which is the past tense of the verb. Most verbs in Arabic contain three-letter root forms while some verbs contain 4 letters in the root form. There are also verbs that contain 5 and 6 letters in the past tense but these verbs are derived from the 3 or 4 letter verbs. For example, the 5 letter past tense verb اِنْكَسَرَ (inkasara) is derived from the 3 letter verb كَسَرَ (kasara) which means "broke".
In concise dictionaries such as المورد القريب , you can search for verbs using their past tense, whether the verb contains 3, 4, 5, or 6 letters in the past tense. You can also search for nouns just as you would in any dictionary.
For example, to search for the noun اِسْتِفْهَام (istifhaam), which means "inquiry", you need to simply look up اِسْتَفْهَمَ (istafhama), which means "to inquire" . In simple dictionaries, you can also search for the noun (masdar مَصْدَر) of a verb, such as اِسْتَفْهَام . However, if you don't find it, then look up the verb.
There are also more complex Arabic – English dictionaries containing more entries than the concise dictionaries, such as the Hans Wehr Arabic – English Dictionary. In this dictionary, you can search for 3 and 4 letter root verbs easily, simply by looking up the past tense of the verb. However, to search for 4 letter past tense verbs derived from 3 letter verbs or 5 and 6 letter past tense verbs derived from 3 or 4 letter root verbs, you need to look up the 3 or 4 letter past tense root word. You cannot find these 4, 5 or 6 letter verbs just by looking up their past tense. Additionally, to look up nouns derived from verbs, even if the noun contains 6 letters or is apparently the noun of a 5 or 6 letter verb, you need to look up the main root of the verb, whether it is a 3 letter verb or a 4 letter verb.
For example, the noun اِسْتِفْهَام (meaning inquiry) comes from the 6 letter verb اِسْتَفْهَمَ . However, the main root of the verb is the 3 letter verb فَهِمَ (fahima) , meaning "understood". So to look up اِسْتِفْهَام you need to look up فَهِمَ and then search for اِسْتِفْهَام in the list of words derived from فَهِمَ .
This sort of dictionary is more complex and more difficult to use. So beginner students should stick to the concise dictionary. However, having this dictionary is a good thing and should be used if you can't find a word in the concise dictionary.
Note: sometimes the concise dictionary will have one or a few common meanings of a word. In that case, you should look up the word in the larger complex dictionary because a word may have many meanings and to properly understand the text you are reading, you will need to know the appropriate definition which may not be the concise dictionary.
Practice – get a concise Arabic – to – English dictionary and practice using it. Also, if possible, get a more complex dictionary for your reference library.
Lesson 17: Negatives
تُفّاحَة apple
أُرِيْدُ I want
يُرِيْدُ he wants
يُسَافِرُ to travel - he is travelling
يَأْكُلُ to eat – he is eating
Negative words used with verbs:
The following words make the sentence negative. They are used with verbs.
لَا is used with the present tense verb. It is for the present negative sentence.
لا أدْرُسُ الآن. I am not studying now.
لا أريد I don't want (it).
لا أريدُ أنْ أدْرسَ. I don't want to study.
لَا أَذْهَبُ I am not going.
لا أذْهَبُ إلى السُّوْقِ الْيَوْم. I am not going to the market today.
You can make negative sentences by simply placing لَا before the present tense verb. For example:
I am studying now. أَنَا أَدْرُسُ أَلْآن.
I am not studying now. أَنَا لَا أَدْرُسُ أَلْآن .
He is eating an apple. هُوَ يَأْكُلُ تُفَّاحَة
He is not eating an apple. هُوَ لَا يَأْكُلُ تُفَّاحَة.
They are travelling. هُمْ يُسَافِرُوْنَ
They are not travelling. هُمْ لَا يُسَافِرُوْنَ
Note: this lesson discussed لا when it is used with the present tense verb. There are also cases where لا is used with a noun. You will learn those types of sentences later, insha-Allah.
Sentence Analysis:
I am not studying now. أَنَا لَا أَدْرُسُ أَلْآن .
أَنَا : stand-alone subject pronoun mabny in the mubtada (subject) position. ضَمِيْر مُنْفَصِل مَبْنِيّ فِيْ مَحَل رَفْعِ مُبْتَدَأ
لَا : negation word. حَرْف نَفِيْ
أَدْرُسُ : present tense verb marfoo' and the sign of رَفْعِ is the damma visible at the end. فِعْلٌ مُضَارِعٌ مَرْفُوْع وَ عَلَامَةُ الرَّفْعِ الضَّمَّةُ الظَّاهِرَةُ عَلَى آخِرِهِ
أَلْآن : word showing time. ظَرْف زَمَان مَنْصُوْب
Practice tip: make present tense negative sentences.
Kokab Rahman is a talented writer, having written many non-fiction articles, how-to-write articles, cultural short stories, and poetry - all loved by readers. One of her short stories, Cyber Lies - the Reality of Internet Relationships, won the 2010 Islamic Board Writing Contest. Several of her articles on the craft of writing were published in the Kansas Writers' Association Newsletter. She has also written course books including English Grammar for Grade 5, Accounting for Beginner, and Arabic Made Easy. The preliminary version of Arabic Made Easy (known as EZ Arabic) was posted on Islamic Board Arabic Forum and was well-received. Being a linguist as well as a talented writer, she is able to present difficult Arabic Grammar material in a simple and uncomplicated manner. Using repetition of difficult material and simple manner of presentation, Arabic Made Easy makes learning Arabic extremely easy. In addition to writing, Kokab is a professional editor and teacher. She provides critiques to aspiring writers, helping them improve their writing.


text:
Great room.
Guest Review Highlights
- Great room
Wego searches multiple travel sites so you can find and compare the best rates.
Based on 10 reviews from across the web.
Great room.
Check-in: 14:00
Check-out: 12:00
A25 Hotel - Luong Huu Khanh is perfectly located for both business and leisure guests in Ho Chi Minh City. The property features a wide range of facilities to make your stay a pleasant experience. All the necessary facilities, including elevator, business center, bar, 24-hour room service, coffee shop, are at hand. Each guestroom is elegantly furnished and equipped with handy amenities. To enhance guests' stay, the hotel offers recreational facilities such as massage. Discover all Ho Chi Minh City has to offer by making A25 Hotel - Luong Huu Khanh your base.


text:
Sheepshead Bay—Homecrest— Manhattan Beach—Gravesend
A thief looted $7,450 in electronics from an Avenue Z business on Nov. 12 — after the security gate had been damaged during a fire at the neighboring building.
The victim told police that he left work between E. 21st and E. 22nd streets at 8 pm, and returned the next morning to find a Dell desktop computer, an Apple laptop, a scanner, copier, and a fax machine had been taken.
There had been a fire at the building next door, and the responding firefighters had cut a hole in the business's security gate and damaged the front door, police said.
A 33-year-old man was arrested for attempting to rob a woman on Avenue W on Nov. 12.
The victim told police that she was between Batchelder and Bragg streets at 2 pm when the suspect pushed her to the ground and attempted to wrestle away the car keys and iPhone from her hand.
But the victim wasn't giving up without a fight, and struggled with the suspect until police arrived and placed the man in custody, cops said.
A burglar ransacked a woman's E. 17th Street apartment on Nov. 12 — taking $21,300 worth of jewelry and cash.
The victim told police she left her home between Quentin Road and Avenue R at noon, and returned shortly after 9 pm to find that her front door had been pried open and that she was missing $300, six gold rings worth $18,000, and a pair of white-gold diamond cuff links worth $3,000.
A thief busted into a 77-year-old woman's Ocean Avenue apartment on Nov. 12, and stole her passport.
The victim told police that she left her apartment between Avenues V and W at 8:30 am, and returned at 9 pm to find her bedroom window ajar and her U.S. passport missing.
A crook burglarized a 78-year-old man's Avenue W home on Nov. 11, taking a $300 bicycle.
The victim told police that he had left his home between Plumb First and Plumb Second streets at 4:30 pm, returning about an hour later to find that his kitchen window was ajar, and that his $300 bike had been stolen.
Some arsonists decided to turn a man's Avenue Z beauty salon into their personal playground on Nov. 11, lighting a fire inside.
The arsonists broke into the business between E. 21st and E. 22nd streets sometime after 6:30 am, where they lit a fire and placed the residents living above the business in extreme danger, cops said.
— Colin MixsonReach reporter Colin MIxson at cmixson@cn
©2012 Community News Group
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text:
Is this attraction pet friendly?
Is this attraction wheelchair accessible?
Does this attraction involve animals?
Is this attraction free to the public?
Is gratuity suggested at this attraction?
Would this be a good rainy day activity?
Is there food available at this attraction?
Is this attraction accessible using public transportation?
Is this attraction closed during certain parts of the year?
Does this activity require advanced planning, ticketing or reservations?
Thanks for helping!
If you are a bird lover, the Audubon's facility here is excellent. Most of the year (but not in the summer, bears are a problem then), their bird feeder is visited by only...
read more
If you are a bird lover, the Audubon's facility here is excellent. Most of the year (but not in the summer, bears are a problem then), their bird feeder is visited by only upscale birds - no pigeons or house finches, which are all town birds. The regulars are chickadees, titmice, nuthatches, and sometimes wrens seldom seen in NJ (we...
Visited the sanctuary, hiked a few trails. Signs need to be updated. Visited a pond but the pond wasn't there just rocks a fountain that didn't work and benches.
This is a wonderful little hike in the woods. Easy to access right off of Hardscrabble Road. There are some beautiful birds seen at this sanctuary. The many different woodpeckers are among my favorite. I have been here many times during all different seasons. Each season has something different to offer. Walking after a fresh snow with all of the...
We have been coming here over the years, 18 years to be exact. A place to feel outdoor, a place to see some birds but mostly we come here to buy bird seeds and things. A bit expensive compared to other stores but birds who come to our bird feeders could decipher which ones comes from this place or from...
The best thing about Sherman-Hoffman is the people. I have been on many of the Saturday am FREE nature walks, and they are excellent. so much to learn. Stephanie leads many of them and her knowledge of the flora and fauna of NJ is legendary. Mike Anderson is also often around the sanctuary, and he is a great birder and...
Great walks on wooden walkways through wetlands area. Great opportunities for photography and viewing birds. We understand they have turtles but we didn't see any.
A center for conservation and education, the Sherman Hoffman Wildlife Sanctuary encompasses 272 acres of deciduous forest, fields, a woodland flood plain, an education centered carriage house, as well as, an estate house with a tree-top observation deck. The estate house is also home to an extensive book store, exhibits and Audubon offices. Their are feeding stations around the estate...
Was a lovely place for your children to learn about our beautiful birds, and other forest creatures.
This large sanctuary has a visitor center, many well marked trails and lovely grounds with a river running through it. It was winter and we saw some birds especially a number of hawks. There are bird feeders near the Center where you observe many small birds. The sanctuary is off exit 30B of I-287 and sits back a few miles...
A great place with many trails and a fantastic gift shop. Often hikes are led by a guide. Trees abound as well as birds and other critters.


text:
bareMinerals Brushless Mascara
Editor's Rating & Review
How we review products
bareMinerals Brushless Mascara Reviews
rather I didn'tthis just made a mess!! — 8 years, 9 months agomeadowwood1 | 413 reviews
Not Quite What I ThoughtI used this product twice and had so much trouble with it I never used it again. It was difficult to manage the stick precisely. The two times I used this mascara it seems like I applied mascara to every part of my eye except my eyelashes, perhaps I should have given it more of a chance and practiced with it, but I really don't want a mascara that I need to spend time perfecting. I did find it ...read moreto be good for applying mascara to the corner lashes, but not the whole set of lashes. The black color is a rich thick black so if you manage to get some on your eyelashes they will be very black, but not that much longer or thicker than if you had used another mascara with a regular applicator. Maybe you will have more success with this product than I did, but I personally would not buy this product again. This single product does not represent what is otherwise a company with excellent natural products. — 7 years agojoannacastle | 19 reviews
Great MascaraThis product is worth the cost and works great. — 7 years, 1 month agokggee1 | 2 reviews
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Music Reviews
The two singers who perform as the Secret Sisters happened to be sisters in real life. Lydia and Laura Rogers have just released their second album, "Put Your Needle Down."
Reviewer Meredith Ochs is dazzled by their timeless sound.
SECRET SISTERS: (Singing) Please don't say goodbye. Give me another try. I'm black and blue worrying over you...
MEREDITH OCHS, BYLINE: The Secret Sisters are lovely. Porcelain-complected, red lip-sticked, blue-eyed and raven haired, their look seems cultivated to match their sound, as flawlessly retro as "Mad Men," as stunning and sassy as Bettie Page. Their voices ring in impeccable harmonies that soar straight into Everly Brothers' territory. And they've found a perfect partner in famed producer T. Bone Burnett, whose distinct sonic stamp frames their songs in a timeless fashion.
SISTERS: (Singing) I cannot find a way to say goodbye...
OCHS: The Secret Sisters' debut album was heavily influenced by classic country singers, having absorbed strum-and-twang while growing up in a musically inclined Southern family. This new album is a leap forward, showing artistic growth and sophistication. You can hear it in the jazz-inflected sound of this song, a demo that Bob Dylan started writing in the 1980s, but never finished.
It's the only song in their repertoire that they don't sing harmonies on, but by adding more lyrics and styling it up, they make it their own.
UNIDENTIFIED WOMAN: (Singing) Let's (unintelligible) be alone when the sun goes down, (unintelligible) I never loved you, baby, my, oh, my, and whosoever told you, told a dirty lie.
OCHS: Even in their lyrics, the Secret Sisters have mastered the art of looking backward and forward at the same time. Their love songs often explore the power struggle in romantic relationships. Sometimes they keep the upper hand, sometimes they don't. But from their lips, even forlorn acquiescence sounds more like ruminating in a Hawaiian paradise than a bad breakup.
SISTERS: (Singing) I'm dreaming on lonely island in a loveless ocean full of misery. I'll die here on my lonely own, unless you give your sweet love back to me.
OCHS: The magic of this new Secret Sisters album is that it transports you to another place and another time. And the music is so gorgeous that it doesn't really matter where or when.
SISTERS: (Singing) Oh, yes, (unintelligible) oh, yeah. You're making me weak. (Unintelligible) and I can't sleep. When are you going to be the death of me?
SIEGEL: The new album from the Secret Sisters is "Put Your Needle Down." Reviewer Meredith Ochs is a talk show host and DJ at Sirius XM Radio.
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text:
Myerstown area man charged in near-fatal abuse of infant son
SOUTH LEBANON TWP., Pa. - A Lebanon County man has been arrested for what authorities described as the near-fatal abuse of his infant son, state police announced Wednesday.
Logan Matthew was charged with felony counts of aggravated assault and endangering the welfare of children.
The nine-week-old boy, suffering a series of seizures, was rushed from his home on Keller Drive in South Lebanon Township, near Myerstown, to the Heart of Lancaster Regional Medical Center in Lititz, Lancaster County, on Feb. 8.
Doctors found the boy to have bleeding on his brain and behind the eyes and at least six broken ribs, according to state police.
The baby, requiring more advanced treatment, was transferred to the Hershey Medical Center, where, investigators said, further evaluation revealed the baby had suffered permanent brain damage and visual impairment as a result of his injuries.
Court documents described a series of incidents in which the baby's mother told investigators that Matthew would "be too rough with him [the baby]."
"Is there a possibility that it could have happened from the way I held him? Yes," Matthew said in an interview with detectives. "There's a possibility that it could have happened from the way I held him, but I don't think so."
Matthew, 24, was subsequently arrested and committed Tuesday to the Lebanon County Prison on $500,000 bail.
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Jens Tholstrup, who was plucked from Warburg's corporate finance department post-merger to become SBC Warburg's mouthpiece, is now returning to the quieter world of mergers and acquisitions. As head of corporate communications in London, Mr Baring's understated charm should help SBC Warburg's case, particularly as it continues to suffer key staff defections.
Defections such as Michael Hammond, SBC Warburg's joint head of equity syndication, who is off to join Fleming as head of European equity capital markets. Get onto it, Francis.
There was an air of eras drawing to an close for Jacob Rothschild yesterday. The announcement that he was taking a less active role at St James's Place Capital, the financial services group he built with Sir Mark Weinberg, was overshadowed by the funeral of his stepmother, Teresa Rothschild, which he attended in Suffolk yesterday. Tess Rothschild had a glittering series of careers, one of which was in British intelligence in the Second World War, where she met her husband, Victor Rothschild, one of Britain's most brilliant scientists. Jacob Rothschild is now spending more time running the National Heritage Memorial Fund, which dispenses pounds 300m of Lottery money a year, than he is running his businesses, including his investment vehicle, RIT Capital Partners.
He said yesterday that setting up the fund, one of five distributors of Lottery money, had taken far more time and energy than anyone had foreseen. What with his other activities such as completing the restoration of Waddesdon Manor, a magnificent Rothschild mansion, "it all got a bit much." He is still keen on investing, though - "I've time to be an investor."
Talk about a damp squib. Jeff Wooller, an accountancy college chief, has been telling everyone about his Ginger Group, which was going to storm the Institute of Chartered Accountants and make it more accountable to the ordinary membership. Come the ICA's annual general meeting though, and he gets just one vote for his proposals, apart from himself and his seconder. Against - all 247 other chartered accountants at the meeting. To be fair, Mr Wooller did receive a few postal votes, but nothing to change the impression of a crushing defeat.
There was a lighter side when a member pointed out that the annual accounts explained "income - money in; expenditure - money out." Why, the member asked to loud rollicking laughter, did income and expenditure have to be explained to chartered accountants? I think we should be told.
Distribution problem: Whittard of Chelsea, the tea and coffee retailer seeking an AIM listing, has found a historic document in its due diligence investigation. A leaflet sent to customers during the Second World War said: "We regret to inform you that, through enemy action, our office and warehouse in Mansell Street have been completely destroyed, together with most of our records." The unflappable tea importers then say they are "exceedingly sorry for the inconvenience. Also it would be welcomed if unpaid accounts could be settled, as we are unable to send out any settlements." As Winston Churchill said at the height of the Blitz: "Business as usual."
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Hotfrog Australia provides information regarding Fines Enforcement Registry in Perth WA. Fines Enforcement Registry is located at 32 Saint Georges Terrace, Perth WA 6000 and provides Courts services. Contact them on 0892350235.
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Glover Street Market
124 N Glover St (at Twisp Ave), Twisp, Washington, USA, 98856
The Glover Street Market has a good selection of healthy groceries and local produce. Made to order organic juices, smoothies, salads, and organic entrees. Coconut vegan ice cream. Eat at counter, take-out or at Twisp Park by the Twisp and Methow rivers.
Reviews (1)
Contributions +86
Healthiest food in the valley - Edit
I love to grab a bite at Glover Street Market! They make beautiful, tasty food from scratch, with love, right before your very eyes. The meals are large, fresh, organic and filling. The spring rolls are awesome and the staff are great. This place does have the most choices for vegans, and now even offers vegan tamales to go at just $3.50 each or 6 for $18. Only thing is, they also offer the addition of locally sourced meats to their entrees and I can't handle the proximity of the meat cooking from the counter seating. My current strategy is to avoid the place during the lunch rush. Thought this review needed an update on account of its ever increasing popularity with carnivores. There is also an organic bakery next door, Cinnamon Twisp, and they will happily make any of their sandwiches or wraps without the cheese, and they also have a couple of vegan treats in the line up (and it never smells like meat).
Pros: Healthy food, Fresh, organic juices
Cons: occasionally crowded if you hit the rush, a little pricey, but quite fair for good food, they serve meat and its stinky
1 Response
mktuttle 07 Oct 2016 - Love your review! I hate stinky meat too!! We are excited to check out Winthrop next weekend.
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Breed (s): Pit Mix
Gender: Male
Age: 8 years
Weight: 50 pounds
Energy Level: High
House trained: Yes
Crate trained: Yes
Microchipped: Yes
Spay / Neutered: Yes
Current vaccinations: Yes
Training: Basic Obedience
Mortiki was abandoned by his owner. He was found tied to the fence of our rescue along with his friend Maya Papaya. The two of them are inseparable. One looking out for the other.
They make a fun pair. Mortiki is full of energy and Maya Papaya is a bit more flexible in her energy.
Please help him find a forever family and home of his own.
For an application email: email@example.com
Adoption donation fee and home inspection required.
Thank you,
Dharma DOG Movement
Love, light & peace,
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As expected, tonight's game between Siena and Catania has also been cancelled because of the snow in Tuscany.
The group in charge of stadium safety at the Stadio Franchi met this morning and decided that the game should be postponed.
It's the third match of the midweek round so far to fall after Parma-Juventus and Bologna-Fiorentina.
Keep up to date with the latest news and action from Spain's Primera Division with Football Espana - from the team behind Football Italia.


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2010 Chrysler Sebring - Hurst TX
http://www.everycarlisted.com/34327-moritz-kia-of-hurst Phone: 888-809-7163 Year: 2010 Make: Chrysler Model: Sebring Trim: Limited Engine: 2.7 liter 6 cylinder 24 valve Transmission: Automatic Color: Gray Mileage: 18472 Address: 110 Northeast Loop 820 Hurst, TX 76053
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Check out our walkaround of the 2012 Kia Optima! The Optima was redesigned last year to rave reviews, even winning the Cars.com 2011 Car of the Year award. It returns for 2012 with the same sharp styling and a pair of powerful engines that give the midsize Optima a combination of looks, practicality, and drive-ability that's hard to beat. Let us know what you think about the 2012 Optima in the comments. Special thanks to Kia Sherman Oaks! For more information on the Optima, or to get a low internet price quote from a local dealer, head over to NewCars.com: www.newcars.com/kia/optima/2012
Tour: 2012 Kia Optima Blake Griffin Edition
Virtual tour from the 2012 Detroit Auto Show of a 2012 Kia Optima customized for the Blake Griffin theme. Basketball textured exterior in House of Color sunset and cinnamon pearl paint, custom wheels, and a host of other visual tweaks, the Blake Griffin Optima was put together by West Coast Customs. Griffin's personal logo sits on the hood. This car also has basketball court floors, leather seats and upholstery, custom embroidery, and Griffin's autograph. An upgraded audio system, flat-screen TVs and an XBox game console round out the in-car entertainment, and a miniature basketball hoop in the trunk. © Redline Werks 2013 All Rights Reserved No part of this video or any of its contents may be reproduced, copied, modified or adapted, without the prior written consent of the author.
2012 Kia Optima review - What Car?
Read the full What Car? Kia Optima review http://bit.ly/Lm4k8Q The Kia Optima is a good-looking family saloon that has lots of space, loads of equipment and a long warranty. The unsettled ride and poor refinement just aren't up to muster, especially when other family cars perform so well in these key areas. The cabin could feel more sophisticated, too, and some versions look pricey. The Kia Optima certainly has its strengths, but it also has some big weaknesses. Most rivals fulfil the family car role better, and some for less money. What Car? is the UK's biggest car-buying brand and has been helping Britain's car buyers make purchasing decisions for over 40 years. Our tests are widely regarded as the most trusted source of new car advice. This channel brings you trusted reviews on all the new models on the market , all the latest first drives, reader reviews, and great car-buying advice. All reviews are available in full online at Whatcar.com - the UK's leading car-buying website, offering trusted reviews and data on every new car. The website also offers advice on car leasing, new car deals and used cars for sale. Subscribe: http://www.youtube.com/user/whatcar Like us on Facebook: http://www.facebook.com/whatcar Visit us online: http://www.whatcar.com Magazine subscriptions: http://www.themagazineshop.com/subscriptions/what-car


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Doing Business in Japan the JMEC Way
Supported by 18 Chambers of Commerce, the Japan Market Expansion Competition (JMEC) is a business training program in Tokyo centered on a business plan writing competition that starts November 5th. Applications due by October 25th. The dual objectives of the program are to strengthen the skills of up-and-coming executives, while assisting foreign companies doing business in Japan.
Fosters development of foreign business in Japan
Teaches individuals about doing business in Japan
Proves hands-on experience writing a business plan
Produces quality business plans that are ready to implement


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Identification of evolutionarily meaningful information within the mammalian RNA editing landscape
- Yiannis A Savva1 and
- Robert A Reenan1Email author
DOI: 10.1186/gb4157
© Savva and Reenan; licensee BioMed Central Ltd. 2014
Published: 28 January 2014
A large comparative genomic sequence study has determined the extent of conservation between RNA editing sites within the mammalian evolutionary tree.
See related research by Pinto et al., http://genomebiology.com/2014/15/1/R5
Expansion of the RNA editing universe
The RNA editing enigma
RNA editing sites are scattered within the human, mouse and Drosophila transcriptomes. Geographically, editing sites are found in both coding regions (exons) and in non-coding regions (5′ UTRs, 3′ UTRs, introns and intergenic) throughout genomes. Another theme from the deep-sequencing era is that much of the informational content of genomes is transcribed into non-coding RNA, whose functions largely remain to be determined. Comparison of RNA editing landscapes between different genetic model organisms has uncovered diverse ADAR substrates and revealed discrepancies within RNA editing systems. While the number of exonic editing sites that lead to non-synonymous amino acid substitutions (genomic recoding) varies significantly across a broad range of organisms, a common theme seems to be emerging. The majority of RNA editing sites are located in non-coding regions within genomes. For example, in the human genome, RNA editing sites are highly over-represented in Alu elements restricted within introns of transcribed genes [3]. Alu elements are lineage-specific repeat genomic sequences, which participate in dsRNA template formation acting as ADAR substrates (Figure 1b). Unlike mRNA targets of ADAR, such more perfect and extensive dsRNA substrates lend themselves to more extensive deamination, with up to 40% of adenosines in the duplex region undergoing modification. Similarly, within the mouse genome the majority of RNA editing sites are found in B1 short interspersed element repeats. RNA editing in non-coding regions of a transcript can have several functional consequences such as: creation or elimination of splicing signals, exonization of repeat elements, nuclear retention, regulation of microRNA (miRNA) biogenesis and function, cellular defense, and regulation of RNA interference [4]. It is thought that the collection of RNA editing sites in an organism's transcriptome contributes equally to the appropriate functioning of the nervous system, as exemplified from the generation of ADAR deficiencies in various genetic models [5]. In Drosophila, deletion of the adar locus results in severe neurological phenotypes, including extreme uncoordination, seizures and neurodegeneration. Furthermore, mice homozygous for ADAR1 null mutations die during early development due to severe apoptosis. In addition, ADAR2 null mutant mice experience repeated seizure episodes and die soon after birth. Interestingly, the lethality phenotype of the ADAR2 null mice is rescued by the introduction of the edited allele of a single RNA editing site in the glutamate receptor channel, GluR-B Q/R site [6]. This observation suggests that certain RNA editing sites are more physiologically critical compared with others existing in the same genome. Thus, a general enigma in ADAR-mediated editing is exactly how to determine which, of many, RNA editing sites are functionally important, and which may have no discernable function.
A unique set of RNA editing sites
In order to identify functionally important RNA editing sites from a vast RNA editing landscape, a recent study by Pinto et al. [7] used evolution as a key discriminator to delineate highly conserved sites in mammalian lineages. Taking advantage of enormous RNA-seq datasets of both human and mouse transcriptomes, the authors applied a standard BLAST alignment tool to compare 40 base pairs upstream and downstream of human genomic sequences surrounding an RNA editing site to the mouse genome. A set of basic filters was applied to the datasets to retain only RNA editing sites located at the same exact position in both human and mouse genomes. Surprisingly, this simple procedure identified 59 highly conserved editing sites. This set of RNA editing sites, which were termed evolutionary selected sites (ESS), represents 0.004% of the known human editing sites to date. Furthermore, the authors demonstrated that the percentage of ESS sites does not increase as RNA-seq data accumulate. Using a small fraction of the available RNA-seq data sets from 15 different mouse strains, the authors were able to retrieve approximately 95% of the ESS sites in any random choice of two mouse strains. While the ESS sites were found across all the mouse strains tested, the non-conserved sites were not consistently detected, suggesting that the ESS set is exquisitely specific. In addition, evidence for the presence of ESS sites can be found in RNA-seq data from an additional four genomes within the mammalian evolutionary tree: rat, cow, opossum and platypus. The presence of ESS sites across large evolutionary distances suggests a functionally important role in mammalian biology for these sites, despite the fact that the set is surprisingly small.
The nature of functionally important RNA editing sites
Due to the degeneracy of the genetic code, RNA editing can cause both synonymous and non-synonymous changes. In Drosophila, the majority of highly conserved RNA editing sites lead to non-synonymous amino acid changes in functionally important and highly conserved residues within proteins. Similarly, the majority of the mammalian ESS editing sites lead to amino acid recoding. Specifically, 37 out of 59 ESS editing sites are found in coding regions of the genome and 35 of them lead to non-synonymous amino acid substitutions (94%). In addition, most of the non-coding ESS editing sites (22/59) occur in transcripts of genes that are also edited elsewhere in their coding sequence. Recent studies in Drosophila identified editing sites in ECS non-coding genomic elements [8, 9]. Not surprisingly, using structural RNA prediction software (mfold), Pinto et al. showed that most of the ESS editing sites in non-coding regions are located in potential ECS elements. Furthermore, two of the ESS editing sites are found in miRNAs in agreement with the previously described regulation of miRNA biogenesis and function through RNA editing. Further analysis revealed certain features of the ESS editing set. First, the ESS editing sites display higher levels of expression when compared with the non-conserved editing sites set. Second, the ESS editing set exhibits higher levels of editing and, more importantly, these levels of editing display striking conservation across 15 mice strains and between human and mouse. These observations indicate that the editing levels of the conserved mammalian RNA editing sites are set within the evolutionary tree and that the precise ratios of edited/non-edited repertoires of protein products may contribute to the optimization of cellular physiology. Lastly, similar to the highly conserved RNA editing sites reported in Drosophila, the ESS editing sites are overrepresented in genes that play a pivotal role in nervous system functions such as synaptic release and ion transport. This observation suggests that natural selection acts through RNA editing to evolve RNA structures that are acted upon by ADARs to genetically recode the proteome associated with neurotransmission and thereby fine-tune brain physiology.
Unweaving the roles of RNA editing
Abnormalities in the RNA editing pathway are associated with multiple nervous system disorders including schizophrenia, epilepsy, suicidal depression and amyotrophic lateral sclerosis [10]. The conserved RNA editing sites within the mammalian evolutionary tree reported by Pinto et al. [7] have the potential to contribute to a better understanding of the link between the RNA editing process and various neurological diseases. With the rapid advent of genetic engineering techniques, specific RNA editing sites could be precisely examined in vivo in various animal models, thus uncovering functions of ESS single RNA editing events. Furthermore, the specific characteristics of the non-conserved set of RNA editing sites prompted Pinto et al. to propose that these events are simply a consequence of overactivity of RNA editing enzymes with no apparent evolutionary value. Certainly, particular specific RNA editing events are under intense selective pressure, yet all RNAs are structured to some degree due to the single-stranded nature of RNA. Many RNAs, from all classes, probably serve as poor ADAR substrates (Figure 1c). Low-level editing of barely structured RNAs is not likely to be under intense scrutiny by natural selection, but sequence variants that become more structured, or obtain more stable structures under altered environmental conditions, may be better ADAR substrates, and then be vetted by natural selection for their adaptive consequences. Further sequence drift, under selective conditions, could shape RNAs into efficient ADAR substrates over generations. Other targets, for instance long dsRNA transcribed from recent duplication or transposition events, may immediately be hyperedited, leading to intersection between RNA editing and small RNA processing.
Multiple reports suggest that the RNA editing pathway is highly sensitive to external and internal stimuli such as temperature and inflammation. Therefore, future studies should aim to investigate how these two different sets of mammalian RNA editing sites respond to alterations of environmental stimuli. Non-conserved RNA editing events within mammalian lineages could represent variations in how RNA editing reshapes a specific transcriptome/proteome in response to external or internal changes in the environment. Such editing sites could represent derived characters, as such, which could then be interpreted as molecular adaptations in cellular functions. Studies such as that by Pinto et al. open the doorway for identifying both the conserved and, perhaps equally interesting, non-conserved species-specific RNA editing events that have shaped, and been shaped by, evolution.
Adenosine deaminase acting on RNA
- A-to-I:
Adenosine to inosine
- cDNA:
complementary DNA
- dsRNA:
double-stranded RNA
Editing complementary sequence
Evolutionary selected sites
- miRNA:
Authors' Affiliations
- Bass BL: RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem. 2002, 71: 817-846. 10.1146/annurev.biochem.71.110601.135501.View ArticleGoogle Scholar
- Hoopengardner B, Bhalla T, Staber C, Reenan R: Nervous system targets of RNA editing identified by comparative genomics. Science. 2003, 301: 832-836. 10.1126/science.1086763.View ArticleGoogle Scholar
- Athanasiadis A, Rich A, Maas S: Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol. 2004, 2: e391-10.1371/journal.pbio.0020391.View ArticleGoogle Scholar
- Savva YA, Rieder LE, Reenan RA: The ADAR protein family. Genome Biol. 2012, 13: 252-10.1186/gb-2012-13-12-252.View ArticleGoogle Scholar
- Nishikura K: Functions and regulation of RNA editing by ADAR deaminases. Annu Rev Biochem. 2010, 79: 321-349. 10.1146/annurev-biochem-060208-105251.View ArticleGoogle Scholar
- Higuchi M, Maas S, Single FN, Hartner J, Rozov A, Burnashev N, Feldmeyer D, Sprengel R, Seeburg PH: Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature. 2000, 406: 78-81. 10.1038/35017558.View ArticleGoogle Scholar
- Pinto Y, Cohen HY, Levanon EY: Mammalian conserved ADAR targets comprise only a small fragment of the human editosome. Genome Biol. 2014, 15: R5-10.1186/gb-2014-15-1-r5.View ArticleGoogle Scholar
- St Laurent G, Tackett MR, Nechkin S, Shtokalo D, Antonets D, Savva YA, Maloney R, Kapranov P, Lawrence CE, Reenan RA: Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila. Nat Struct Mol Biol. 2013, 20: 1333-1339. 10.1038/nsmb.2675.View ArticleGoogle Scholar
- Rodriguez J, Menet JS, Rosbash M: Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Mol Cell. 2012, 47: 27-37.View ArticleGoogle Scholar
- Slotkin W, Nishikura K: Adenosine-to-inosine RNA editing and human disease. Genome Med. 2013, 5: 105-10.1186/gm508.View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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D300 for sale
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Hamilton Nash Registered since 28th Oct 2009
Mon 16-Nov-09 09:33 PM
I have a 2 year old D300 body for sale. All original packaging and receipts if needed. Toronto area. I am upgrading to a D700. Camera was taken care of from the beginning. Cash only.
Visit my Nikonians gallery.
#1. "RE: D300 for sale" | In response to Reply # 0reuben Nikonian since 21st Jan 2004Mon 16-Nov-09 11:54 PM
Please see this duplicate post.


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Five dead, police closing in on 11 other shooting cases
You can run, but you cannot hide - this appears to be the message from the Penang police as the heat is on for a group armed hardcore thugs linked to 11 shooting cases since early this year.
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CE, my problem is Walt over paid for a guy that was traded for Troy Glaus, what, a year ago? He gave up two of the Reds top 10 (likely) prospects and starting 3B for a guy with declining skills and health issues. He didn't touch the areas of serious need CF, SS, and ignored his growing SP problems. He also traded some SP depth, for a guy that offensively is not an upgrade to EE, though defensively he's obviously superior.
I agree that not every prospect makes it, but there was no need to take on 11 mil in salary next year for a 35 year old 3B, especially when you have so many other holes to fill.
Raisel Ghul, the Demon's Head
The eyes never lie.
Not only did he trade Stewart he did it while knowing Volquez was going to have surgery today. It's just confusing all around.
At least we don't overvalue Reds prospects around here.
And by the way ... Keith Law's list doesn't matter. What matters is how the various organizations (and the Reds) rank these guys. And we don't know that.
doug does tend to overvalue reds prospects, but he's not wrong on this.
Jan. 14 2008, Rolen was traded to Toronto for Troy Glaus.
Glaus has never been considered a good fielder, though he's probably better than EE. So why is Rolen now worth three players to a team that isn't going to contend this year, or next if the holes at SS and CF and SP aren't filled? Especially when one of those holes, SP, could potentially have been filled by Stewart ala Cueto in 2008?
dumb trade.
Raisel Ghul, the Demon's Head
The eyes never lie.
"No matter how good you are, you're going to lose one-third of your games. No matter how bad you are you're going to win one-third of your games. It's the other third that makes the difference." ~Tommy Lasorda
Have Stewart/ Roenicke got any pt yet?
Baseball is like church. Many attend, few understand
But I do want to put a myth to bed about a thing or 2. #1 My dissatisfaction with the deal has little to do with how Doug views them and although I only speak for myself on it I think many others would tell you the same. Now does Dougs reports on a player sway my opinion about a guy, sure it does he sees them and I agree with his philosophy about how to value a prospect (i.e. stats/scouting reports). He also speaks to scouts and others who have valuable facts and opinions. I take all facts I can get from Doug and others about players and to a small extent I may take some folks opinions as well. I combine those things with what what I know about a player already. And that is how I have arrived to Stewarts worth (as well as other prospects). So let's not blame Doug for the disappointment others have shown for this deal.
Secondly let's try to look at this deal objectively, let's just forget the names a second. Trading away a kid who throws 2 plus pitches (one of which is a mid 90's sinking Fastball) , showing the feel for another average or better pitch, the aptitude/feel for pitching, with command and control who has shown the ability to maintain his velocity late into games consistently for a guy who although makes us better in the short term has a history of breaking down is 34 and not hitting for power anymore straight up is a bad deal. You simply don't trade arms like that for anything short of something impactful and fairly long term. Forget the rest of the deal that right there is the problem in a nutshell. Evrything else is just gravy. This is eerily reminiscent of the Dan Haren deal only that time Walt at least in theory got a potential impact LHP in his early prime.
I think most of us will eventually move on and understand there is nothing that will change that deal. However this is just another critical mistake in what is becoming a long line of them. That IMO started with relieving Mackanin and then Krivsky of their jobs and why, public relations just like this Rolen deal. Got to keep those buts in the seats even if it means dropping talent left and right.
"You can't let praise or criticism get to you. It's a weakness to get caught up in either one."
--Woody Hayes
This was stated before, but let me re-emphasis...
Why are we listening to him?
He raked the Reds over the coals on the Hamilton/Volquez deal because the thought that Volquez would never be more than a middle reliever.
He said that the Reds pick of Cozart was the worst 2nd round pick that year because he will never be anything other than a light hitting utility guy.
I could go on forever with some of the misreadings that Law has made since joining ESPN. Just like Steve Phillips, there's a reason why he is working in journalism and not for a major league team. His rankings mean squat to me.
"Imagination is more important than knowledge." -- Albert Einstein
Here is the issue with this trade. The consensus on this board seems to be that Harang, Arroyo and Cordero have contracts that must be purged for this team to re-tool and fill its holes on the staff and on the field. This deal is a step in the opposite direction:
1. Stewart was the only pitcher in the high minors with a remote possibility of filling a spot in the top three of the rotation. Like it or not, Harang and Arroyo are ticketed for those spots and will need to be replaced when they go. The other guys in the high minors - Maloney, Lecure even Wood - are all back of the rotation guys if they pan out. I get the idea that pitching prospects frequently fail. But IMO that doesn't mean they should be discarded, it simply means that you need more of them to increase the chance of successfully finding one of them. I do think Stewart probably needed another full year building innings in AAA before he would have been ready for a rotation spot in the big leagues. Its true that the team could sign some one new if these contracts are off the books, but does anyone think this organization would be able to find anyone better for any less money on the free agent market? I think any replacement brought in will not be from the top shelf guys available, they would be secondary guys who didn't get the big moeny from the big dollar contenders. Of course they'll want that big money to come and pitch in a place like Cincinnati that hasn't been in the play-offs in a long time. That would leave us with contracts not unlike the ones Harang and Arroyo have now given to pitchers who perform similarly to how Harang and Arroyo perform now. The difference being they'll be new contracts that will be on the books for longer. Purging Harang and Arroyo without having replacements from within available seems like a dead end to me.
2. Cordero is very pricey for a role with such questionable value, but "closer" seems unimportant until you don't have anyone to close and the team is coughing it up every day. I'm on record saying the team needs a channging of the guard in the pen in order to free up some cash for other needs. Unfortunately, Stewart was the guy in the high minors who could likely have filled that role successfully. If not him, then Roenicke was the next choice. Now the team needs more stability from Masset (shakey of late) or a big comeback out of Jared Burton (or of all people Bill Bray) if it wants to move on. It may be easier to get some one cheap on the market here than in the rotation, but there is no question that dealing Stewart and Roenicke will make the transition from Cordero and Weathers much more difficult.
3. Rolen is probably a decent upgrade from EdE (though I think EdE's offense is under-rated by many on here). But at $11 Million in 2010 with a shakey health outlook, its a big risk for a team with so many other needs and such a limited budget. The Reds are the team taking on the risk here. They overpaid in arms because the Jays were willing to walk away from the deal, while the Reds were fulfilling a man-love driven quest and gave in. The Reds should have called J.P.'s bluff and walked away themselves. This season is toast anyway. I'd bet the Reds could have acquired Rolen at the Winter Meetings for a lot less. That is, of course, only my specultaion and we'll never know, but I'll never be convinced that this team didn't overpay. EdE and Maloney should have been plenty to get it done. Waiting until the winter meetings would have meant that the team did not need the cash coming back to pay Rolen's salary for the rest of 2009 and would have automatically reduced the talent required to do the deal.
4. Selling off those arms for the Jays taking on some money was unwise. Keep the arms and deal Weathers and Willy if possible to recoup the cash. Deal what's left of Gonzo or Ramon. Sell lesser prospects for cash, but don't sell off the prospects who could make a difference. This team is flush with role player, bench player depth. Stewart was one of a very few who could possibly be a difference maker. Probably the only arm in the organization with that potential (Mike Leake is still unknown).
"All I can tell them is pick a good one and sock it." --BABE RUTH
Having better players makes "the right time" or "the big hit" happen a lot more often. PLUS PLUS
Raisel Ghul, the Demon's Head
The eyes never lie.
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