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Mallory bodies (MBs) and hyaline globules (HGs) are recognized as hepatocellular cytoplasmic inclusions in liver diseases. We reviewed 123 intrahepatic cholangiocarcinomas (ICCs) and encountered 16 cases (13.0%) in which cancer cells had MB-type inclusions and/or HG-type inclusions, both of which are positive for p62 and ubiquitin. The HG type was present in all 16 cases, and 5 cases contained the MB type. Of 16 patients, 12 had chronic liver disease that was related to alcoholic abuse in 4, hepatitis B surface antigen–positive in 3, and hepatitis C virus antibody–positive in 8. Viral infection and liver cirrhosis were more common in ICCs with p62+ inclusions (P = .0004 and P = .0199, respectively). Of 16 ICCs, 15 with hyaline inclusions had a peripheral tumor location (P = .0052). On ultrastructural examination, the MB type had an electron-dense fibrillar appearance, while the HG type appeared as rounded masses of granular materials. Our results suggest that intracytoplasmic hyaline bodies occasionally can be found in cholangiocarcinoma with chronic liver disease related to viral hepatitis or alcoholic intake.
Mallory bodies (MBs) and hyaline globules (HGs) are characteristic hepatocellular cytoplasmic inclusions in the liver.1,2 The MB is a form of hyaline degeneration of hepatocytes seen in hepatocellular carcinoma (HCC) and liver diseases, including alcoholic hepatitis, nonalcoholic steatohepatitis, and cholestatic liver diseases, such as primary biliary cirrhosis.1–5 Intracytoplasmic HGs have been well recognized as a histologic finding in HCCs,6–10 but HGs and MBs can be found in pheochromocytoma, renal cell carcinoma, and breast and lung cancers.11–14
p62 is a stress-inducible protein that has a role as an adapter molecule in cytokine signaling pathways.15,16 It is also a major component of MBs and HGs present in tumor cytoplasm of HCCs.4,17 MBs consist of aggregated keratins, particularly keratin 8, ubiquitin, heat shock proteins, and p62.18–21 However, HGs lack keratin and differ from MBs in their morphologic appearance.2,22 In contrast with the irregularly shaped MBs, HGs are well-circumscribed, homogeneous, eosinophilic globules.2,6 p62 was isolated by enzyme-linked immunosorbent assay in HCC23; however, 1 of 2 cases of cholangiocarcinoma expressed p62 in cancer cells.24 In addition, p62 expression is observed in carcinomas of the gastrointestinal tract and in aggressive breast cancers.25–27
It remains unknown whether intrahepatic cholangiocarcinoma (ICC) with p62+ hyaline inclusions exhibits any specific or characteristic clinicopathologic features. We reviewed a series of 123 patients with ICCs and encountered 16 cases in which cholangiocarcinoma cells showed cytoplasmic changes resembling MBs and HGs. Based on the histologic, immunohistochemical, and ultrastructural observations, we clarified the clinicopathologic characteristics of cholangiocarcinoma with hyaline inclusions and investigated whether the nature of the inclusions was the same as or different from that of HCC.
Materials and Methods
Tissue Specimens and Patients
We reviewed the sections of 123 surgically resected cases of ICCs submitted to the Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan, from 1985 to 2007. The histopathologic definition of ICC was based on the classification proposed by the World Health Organization.28 In this study, cholangiocarcinoma cases included the definite adenocarcinoma component arranged in a tubular manner or nests with mucin production Image 1A. The HCC-like trabecular pattern was not included. All 123 cases were positive for cytokeratin (CK)19 and/or MOC-31 by immunohistochemical analysis. Cases with other primary adenocarcinomas, such as of the gastrointestinal tract, breast, or lung, were excluded. Mucin production of cancer cells was confirmed by staining with alcian blue and periodic acid–Schiff (PAS) with diastase. Whenever possible, multiple sections of tumor were examined, and we obtained tumors with intracytoplasmic hyaline inclusions, which contained MB-type and HG-type inclusions. We defined MB-type inclusions as irregular reticular eosinophilic inclusions identical to alcoholic hyaline Image 1B and HG-type inclusions as sharply circumscribed, round or oval, eosinophilic globular bodies partly surrounded by clear halos Image 1C. Cases of cholangiocarcinoma with an area of Hep Par 1–positive or α-fetoprotein–positive carcinoma cells, indicating combined HCC and cholangiocarcinoma, and cholangiocarcinoma with rhabdoid features were excluded. ICCs lacking hyaline inclusions were studied for comparison.
The patients included in the study ranged in age from 33 to 90 years (mean, 63.9 years); 78 were men and 45 were women. Hepatitis B surface antigen was positive in 16 cases, and hepatitis C virus (HCV) antibody was positive in 23 cases. Liver cirrhosis was found in 21 cases. The mean tumor diameter was 4.23 cm (range, 1–12 cm), and vascular invasion was positive in 79 cases (64.2%). Tumor location was divided into a hilar type of ICC (n = 51), which involved a large bile duct, and a peripheral type of ICC (n = 72), which involved bile duct smaller than segmental branches, based on the gross and histologic classification in a previous study.29 Sections of the nontumorous liver were examined for the presence of cirrhosis and the presence of MBs in adjacent hepatocytes.
Our study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki. For strict privacy protection, identifying information for all samples was removed before analysis.
Immunohistochemical Analysis
Formalin-fixed specimens were embedded in paraffin. Deparaffinized and rehydrated 4-μm sections were stained with H&E for microscopic evaluation. In addition, PAS staining with or without diastase for hyaline inclusions was performed.
For immunohistochemical studies, we selected representative specimens, and the following primary antibodies were used: p62 (guinea pig polyclonal, dilution 1:200; Progen, Heidelberg, Germany), CK19 (mouse monoclonal, dilution 1:100; DAKO, Glostrup, Denmark), CK8 (mouse monoclonal, dilution 1:100; DAKO, Carpinteria, CA), MOC-31 (mouse monoclonal, dilution 1:200; DAKO, Carpinteria), ubiquitin (rabbit polyclonal, dilution 1:500; DAKO, Glostrup), and vimentin (mouse monoclonal, dilution 1:25; DakoCytomation, Carpinteria). These primary antibodies were incubated at 4°C overnight. The subsequent reaction was carried out using a streptavidinbiotin-peroxidase method (Histofine, Nichirei, Tokyo, Japan). Peroxidase reactivity was visualized by using 3,3′-diaminobenzidine. No significant staining was observed in the negative control samples, which were prepared using the mouse immunoglobulin at the same concentration. For positive control samples, hepatocyte for CK8, bile duct for CK19 and MOC-31, muscular cells for vimentin, and neural inclusions of Alzheimer disease for p62 and ubiquitin were used. MBs consist of p62 protein and keratins, particularly CK8, whereas HGs lack keratins, so we performed double immunostaining with p62 and CK8. CK8 staining was developed with a peroxidase-conjugated secondary antibody, and p62 staining was developed with an alkaline phosphatase–conjugated secondary antibody.
Electron Microscopy
Electron microscopic examination was performed in 4 cases using standard methods on tissues reprocessed from the paraffin blocks.
Statistical Analysis
Statistical analysis to compare the relationships between the presence of hyaline inclusions and clinicopathologic factors was performed by using the χ2 test, Fisher exact test, and Student t test for tumor size. Patient survival was defined as the period of survival between surgery and the date of the last follow-up or until death of disease. Survival curves were compared by using the log-rank test. A P value of less than .05 was considered statistically significant.
Hyaline Inclusions and Immunohistochemical Results
The light microscopic examination of 123 cholangiocarcinomas showed that hyaline inclusions were present in 16 cases (13.0%). Hyaline inclusions were not homogeneously distributed and were commonly located in the cytoplasm of cancer cells. Table 1 summarizes the clinicopathologic characteristics and immunohistochemical results for 16 patients with ICC with hyaline inclusions. The mean age of the patients was 66.0 years (range, 50–88 years). Of the 16 cases, 10 were in men and 6 in women. HG-type inclusions were present in all 16 cases Image 2A and Image 2B, and 5 cases contained MB-type inclusions Image 3A, Image 3B, and Image 3C. PAS stain with or without diastase was negative for MB-type and most HG-type inclusions Image 2C and Image 3D, but some HGs in 2 cases were positive for PAS with diastase (Image 3D).
Most hyaline inclusions in all 16 cases were strongly positive for p62 Image 2D and Image 3E; in contrast, 107 ICCs without hyaline inclusions were negative for p62. One case with the HG type revealed CK8+ HGs, but 10 other cases with the HG type showed no CK8 expression Image 2E. CK8 was expressed in many MBs and in a small number of HGs in 5 cases with both MBs and HGs Image 3F. Ubiquitin was also expressed in all 16 cases with hyaline inclusions and was detected in many but not all hyaline inclusions Image 3G. Vimentin expression was not observed in any inclusions Image 2F.
A review of medical records revealed that 4 patients had a history of alcohol abuse, 3 patients were positive for hepatitis B surface antigen, and 8 patients were positive for HCV antibody. Four patients had no viral infection and no history of alcohol abuse. Liver cirrhosis was present in 6 cases, and 4 alcoholic livers revealed MBs of the hepatocytes in nontumorous tissue.
Electron Microscopic Findings
On ultrastructural examination in 4 cases, tumor cells having MB-type inclusions showed an electron-dense, fibrillar, or granular amorphous appearance Image 4A, whereas tumor cells of HG-type inclusions showed a rounded matrix consisting of electron-dense, granular materials with lighter vacuoles Image 4B and Image 4C.
Comparison With Control Cases
The comparison of the presence of p62+ hyaline inclusions in ICCs and clinicopathologic factors is summarized in Table 2. Viral infection with HBV or HCV and liver cirrhosis were more common in ICCs with p62+ hyaline inclusions than in ICCs without (P = .0004 and P = .0199, respectively). All ICCs having hyaline inclusions except for 1 case had a peripheral tumor location (P = .0052). Significant differences were not detected between the presence of hyaline inclusions of ICCs and other clinicopathologic factors. The survival rates for patients with p62+ ICC at 3 and 5 years were 50.3% and 25.2%, respectively, whereas those for patients with p62– ICC at 3 and 5 years were 47.2% and 37.8%, respectively. There was no statistical difference in survival rates between the 2 groups.
Hyaline inclusions are characteristic features of HCC, but malignant liver tumors with rhabdoid features and hepatic embryonal sarcoma have a globular hyaline-like structure.30,31 The evaluation of intracytoplasmic hyaline inclusions of cholangiocarcinoma is extremely limited, and hyaline inclusions have not been reported in cholangiocarcinoma.6 However, on the basis of histologic and immunohistochemical observations, 16 (13.0%) of 123 cases of human ICC were found to contain hyaline inclusions, which are reactive for p62 and ubiquitin proteins. The ICCs with hyaline inclusions that we examined contained no definite HCC areas.
In our study, 2 types of hyaline inclusions were recognized: the MB type, which was morphologically identical to the type described by Mallory as alcoholic hyaline, and the HG type, which was made up of sharply circumscribed, oval or round masses. Norkin and Campagna-Pinto6 demonstrated that reticular hyaline identical to MBs was never stained by PAS stain; however, the PAS stain of HGs was variable and controversial.6,9,10,32 Our identified MBs were negative for PAS, and a small number of HGs were positive for PAS. If abnormal keratins are present in addition to p62, leading to MBs, and if p62 is induced alone, HGs may arise,17 and morphologic transitions of HGs and MGs have been reported.17,33 In the present study, 5 cases showed mixed MB and HG types, an observation that might have resulted from a coincidental association of both types of inclusion. Hyaline inclusions of ICCs as determined by electron microscopic study show striking similarities to those of HCCs. Hyaline inclusions of HCCs include MBs, megamitochondria, lysosome, and endoplasmic reticulum.7,9,10,33,34 MB-type inclusions of ICC consist of an electron-dense granular appearance, presumably alcoholic hyaline, which is regarded as PAS– in HCCs,9 while some HG-type inclusions of ICC appear as masses of granular materials with lighter vacuoles identical to the giant lysosomes detected in HCCs.7,10
Liver cirrhosis, chronic viral hepatitis including HBV and HCV infection, and heavy alcohol consumption have been recognized as risk factors for the development of cholangiocarcinoma.35–40 Yamada et al41 suggested that interlobular bile duct damage observed in alcoholic injury was similar to that of viral hepatitis. Bile duct dysplasia can be found in the pathologic conditions of HCV infection and alcohol intake.42 An important mechanism implicated in alcohol-related and HCV-associated hepatocarcinogenesis is oxidative stress.43,44 DNA fragmentation indicating the generation of reactive oxygen reflects a genotoxic effect of alcohol or HBV and HCV in hepatocarcinogenesis.45 Aggregation of p62 and misfolded keratin, major components of hyaline inclusions, were preferentially induced by chronic oxidative stress.46–49 In this study, ICCs with hyaline inclusions showing peripheral tumor location were related to viral infection and liver cirrhosis. Therefore, viral infection, such as HBV or HCV, and alcohol intake may contribute to the formation of hyaline inclusions and cholangiocarcinogenesis in peripheral-type ICC. Combined HCC and cholangiocarcinoma, mixed phenotype, seems to be arising from a common bipotential progenitor cell. Hyaline inclusions were commonly found in HCC cells; therefore, some cholangiocarcinomas having hyaline inclusions may be derived from a bipotential progenitor cell.
Immunohistochemical stains for p62, ubiquitin, and CK8, as well as electron microscopy, reveal that hyaline inclusions detected in ICCs resemble those confirmed in HCCs. Although the presence of intracellular hyaline inclusions in liver tumors as obtained by core needle biopsy or aspiration cytology is supportive of a diagnosis of HCC,34 our results suggest that intracytoplasmic hyaline inclusions occasionally can be found in cholangiocarcinoma with chronic liver disease related to viral hepatitis or alcohol intake.


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Red Cabbage Alsacian Style
|2 Tablespoon
|1 Medium, sliced
|2 Tablespoon
|1 Tablespoon (Leveled)
|Red cabbage
|1 1⁄2 Pound, shredded
|Boiling water
|1 Pint
|4 Ounce, stoned
|Cooking apples
|4 Ounce, diced
|2 Teaspoon (Leveled)
|Cold water/Red wine
|1⁄2 Cup (8 tbs) (Use A Little)
|1 Teaspoon (Leveled)
|Mixed spices
|1 Pinch
1) In a thick pan, over low heat, heat oil and sauté onion in it until transparent.
2) Stir in vinegar, sugar, cabbage, water, prunes and apple and cover and simmer the mixture, stirring frequently.
3) When the cabbage is just soft, uncover and simmer the mixture to allow reduction in water.
4) Blend cornflour with cold water or wine.
5) Add this to the cabbage mixture and boil till the mixture thickens.
6) Mix in mixed spices, salt, more sugar and more vinegar.
7) Serve hot.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 240 Calories from Fat 70
% Daily Value*
Total Fat 8 g12.3%
Saturated Fat 1.1 g5.3%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 347 mg14.5%
Total Carbohydrates 43 g14.4%
Dietary Fiber 7.2 g28.8%
Sugars 25 g
Protein 4 g7.4%
Vitamin A 42.7% Vitamin C 170.4%
Calcium 10.7% Iron 9.9%
*Based on a 2000 Calorie diet

subset: commoncrawl


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Royal & SunAlliance, the FTSE 100 insurance giant, will this week launch a £900m rights issue as it sets out a strategy to return the company to growth after its mauling during the bear market.
The company is promising to invest heavily in the general insurance business, and is expected to say it sees particularly interesting potential in the UK commercial insurance market, where premiums have soared.
The final size and structure of the rights issue are yet to be decided, but rumours in the market last week suggested it would be priced at around 100p, a discount to the prevailing share price of 30 per cent.
The company will have a meeting with its advisers today to kick-start the countdown to an announcement on Thursday, which will come alongside the group's interim figures and the results of a strategy review conducted by the new chief executive, Andrew Haste. Cazenove, Merrill Lynch and Goldman Sachs are working on the deal, which they hope can raise £900m.
Big claims against RSA's general insurance arm, including for asbestosis, coincided with the stock market downturn which drained its life insurance business of capital. RSA admitted last year it was short of at least £700m it needed to take on new business and Bob Mendelsohn, then chief executive, quit.
RSA needs extra capital if it is to be able to underwrite additional insurance business.
Mr Haste believes that the City is ready to back a rights issue that it would not support under previous management. The company has pulled itself back from the financial brink, raising £540m through the flotation of its Australian life business, Promina, in May and slashing the dividend by almost two-thirds. The company has also closed its UK life insurance arm to new business, having failed to sell the division last year.
Ben Cohen, insurance sector analyst at UBS, told clients last week: "We believe the group will need to pursue a growth strategy at some stage, if it is to have a future in which investors will want to invest. We assume that UK commercial and personal, Scandinavia, and US personal lines will remain the core ... It will be difficult, given capital constraints, for this growth to be fuelled solely by retained earnings."
RSA shares have been one of the best-performing blue chips this year, and have risen 150 per cent since their nadir in March, when the company was temporarily ejected from the FTSE 100. At its peak in 1998, two years after the company was formed from the merger of Royal Insurance and Sun Alliance, the stock traded at more than £8.
Investors expect RSA to show that results are continuing on an improving trend, with the second quarter beating the first quarter's operating profit of £175m. A relative absence of natural disasters as well as higher premium levels mean many insurers are enjoying a purple patch.
However, Mr Haste must answer questions on the level of reserves needed to back the closed life fund. He will also need to dispel fears that, by raising capital so late in the insurance cycle, RSA has missed out on the very large rises in premiums introduced in the wake of the 11 September terrorist attacks.
Mr Haste joined RSA in April from Axa Sun Life. The company also has a new chairman, having replaced Sir Patrick Gillam with John Napier, who also chairs the water group Kelda.Reuse content


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Last Updated: 2/22/2017 11:25 AM
Description for Northland Big Rapids, MI 49307
Versatility of spaces and affordable lease rates make this Retail Center a great option for both small businesses and National Retailers alike. Many combinations for available space ranging from 1600 to 22,645 SF. Possible uses include retail shop, offices, warehouse space or automotive. Current long term tenants include Save-A-Lot, Sears, Beagle Fit Gym, Label Shopper Discount Clothier, and Fresenius Dialysis Center. Center is located near all area major auto dealers and minutes from Ferris State University. Outlots also available. Agent is Member of LLC.SPECIAL NOTES: Commission Paid on original 5 year term only. Fiber optic technology available
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The NIH/NCRR sponsored breeding programs of the National Primate Research Centers commonly house rhesus macaques in multimale-multifemale social groups in large outdoor corrals. This breeding program aims to develop cost-effective methods for enhancing reproduction to increase the number of monkeys available for research and to provide appropriate socialization for their psychological well-being. Although these outdoor corrals simulate natural social and environmental features, one of the most difficult problems in managing socially-housed macaques is their propensity for deleterious aggression. From a management perspective, such aggression is undoubtedly the most problematic behavior observed in group-housed rhesus macaques which can readily escalate to the degree that it results in serious physical trauma, lower reproductive performance and reduced psychological well-being. For over three years we have been conducting an NIH-funded R24 study using social network analysis to examine the internal (e.g. group composition, personality and temperament) and external (e.g., management factors) that influence rates of deleterious aggression and wounding in group-housed rhesus macaques. Our research has provided strong evidence that individual, family and group characteristics such as temperament, family structure and sex ratio interact to influence network structures such as patterns of submission, reconciliation, grooming and conflict intervention that are indicative of group stability and consequent deleterious aggression and wounding in captive rhesus macaques. The goal of this competitive renewal is to actively apply these results, which delineates three major pathways for reducing deleterious aggression/wounding in rhesus groups, to implement a series of perturbations that will experimentally test our correlational findings. Experimental perturbation of the pathways most important to reducing social instability will be conducted to causally validate which pathways are critical for group stability. This validation will allow us to advise colony managers at NPRCs and other primate facilities to use active and adaptive approach to management to reduce deleterious aggression and prevent severe outbreaks in arouo-housed rhesus macaques.
This study will advance the current understanding of deleterious aggression in captive nonhuman primates using an experimental social network approach that will allow the development of an adaptive management program for primate facilities that will enhance group stability and successfully reduce deleterious aggression and prevent severe outbreaks in group-housed rhesus macaques. Rhesus macaques are an important biomedical model for human health research so this research is relevant by addressing the 3R's.
|Beisner, Brianne A; McCowan, Brenda (2014) Signaling context modulates social function of silent bared-teeth displays in rhesus macaques (Macaca mulatta). Am J Primatol 76:111-21
|Chan, Stephanie; Fushing, Hsieh; Beisner, Brianne A et al. (2013) Joint modeling of multiple social networks to elucidate primate social dynamics: I. maximum entropy principle and network-based interactions. PLoS One 8:e51903
|Beisner, Brianne A; McCowan, Brenda (2013) Policing in nonhuman primates: partial interventions serve a prosocial conflict management function in rhesus macaques. PLoS One 8:e77369


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"Bones" Season 9 begins with a lot of tension between Booth (David Boreanaz) and Brennan (Emily Deschanel). Throughout the season premiere, "The Secrets in the Proposal," this tension is evident. See it for yourself in these video clips from the episode.
The first video (above) shows just how tense things have gotten between Booth and Brennan in the time since Pelant made Booth break off the engagement. Why is it so very tense? Keep in mind that Booth can't tell his beloved what's up unless he wants Pelant to go after and kill innocent people.
Talk about stuck between a rock and a hard place.
"Have you noticed dead bodies always save Booth from confronting his demons?"
Booth isn't answering anyone's calls these days. That makes the crime scene uncomfortable when we find out that Booth also missed a call from Brennan — to her, love isn't real without something to back it up, after all.
Sure, Booth says that he loves Brennan. But can she believe him when he's lying about his whereabouts? Because Booth is totally lying about just being at work. Where else was he? The next video holds part of the answer.
Is confession valid if it's done with drinks in a bar? It certainly works for Booth, at least a little bit.
"Bones" Season 9 begins Monday, Sept. 16 at 8 p.m. on FOX.


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Dr. Bami Bastani is head of GLOBALFOUNDRIES' radio frequency (RF) business unit, responsible for expanding the organization's business leadership position in RF.
Bastani has more than 35 years of industry experience in the semiconductor industry, including component to system-level RF technologies. Prior to joining GLOBALFOUNDRIES, he was president, CEO and board member of Meru Networks, a global enterprise-grade Wi-Fi networks solution provider. During his time with the company, Bastani transformed Meru Networks from a hardware company to a solution provider, delivering a portfolio of software, software-defined networks (2015 SDN Excellence Award) and subscription cloud offerings (WaaS).
Dr. Bastani has also held positions of president, CEO and board member in the mobility, consumer and broadband markets, including president and CEO of Trident Microsystems, Inc. and ANADIGICS, Inc. In addition, he has served in executive positions at Fujitsu Microelectronics, National Semiconductor and Intel Corporation.
Dr. Bastani holds a Ph.D. & MSEE in Microelectronics from Ohio State University.
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"Bad Bevesen is a hot springs salt water resort area. It is probably the main such resort in North Germany and includes the spa facilities in the room price (a $40/person value). The rooms are spacious with sitting balconies designed for weekly stays although you can stay single nights or more. ..."
f, Jul 2016, US
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This is the February 21, 2013 news archive. View today's White Sox rumors and news.
Chicago White Sox
Chicago White Sox News and Rumors
Sale sticking with day-to-day statusMLB.com Updated Feb 21, 2013The White Sox have adjusted his schedule to give Chris Sale two days off in between throwing, meaning he won't pitch again until Saturday following his live batting practice session Wednesday.Share Tweet
Rienzo pushes forward following his suspensionMLB.com Feb 21, 2013Picture a kid on Christmas morning, opening his presents and getting everything he possibly wanted. That sort of happy reaction presents just a small sample of Andre Rienzo's demeanor every day during White Sox camp.Share Tweet


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This week I've been eating...congee
A few months back, while interviewing the writer, chef and all-round nice man Simon Hopkinson for My Life in Food in these pages, he mentioned congee, a Chinese porridge, which, he said, was great for hangovers or as a comforter when you're feeling under the weather.
Well, at the end of the last week, the weather was heavy and I was definitely under it. Bored, sneezing and with a head that felt like it had been weighted with building sand, I went to Kam Tong, an unfussy Cantonese restaurant in London's Queensway, under chef Chris Kwan, formerly of Zen Mayfair,
I had the congee with 1,000-year egg. Out it came, a steaming bowl of a translucent rice boiled off in stock with the alkali-cooked eggs swimming in it. The eggs were a delight of squidginess but just footnotes to the rice itself, which had a texture looser than porridge with a deeply savoury flavour. It didn't cure, but certainly cheered me.
A swig of Spain
Say hello to Federica, the new drink from Valencia in Spain. Billed as a sort of Spanish take on Limoncello, it's made from lots of sunny ingredients such as oranges, grapes and other citrus fruits from the eastern seabord city. Sound a little tame, right? Actually, it kicks well beyond it 30 per cent alcohol content. Although the bottle suggests mixing it into a gin and tonic or adding a dash of it to a jug of sangria, I thought it was at its best served on the rocks with lots of ice. Let's just hope the sun returns so we can drink it outside, as the Spaniards do. £24.99, selfridges.co.uk
Fast fish cakes
After a long day at work it's nice to come home and unwind by cooking dinner from scratch. But sometimes, when its 8pm and you're starving, you really can't be bothered. Well, for those times you can do worse than the new range of fish cakes from M&S. The two haddock and minted pea creations are particularly great, the fish not overtaken by the potatoes, while the Thai prawn and cod gets a thumbs up, too. The cod, tomato and pesto version, less so. £2.99, marksandspencer.com
Bacon jammin'
Food mash-ups are mercurial things. Sometimes they work (think Heston's bacon-and-egg ice cream), sometimes they definitely don't (garlic beer, anyone?) and sometimes you don't know what to think, as with EAT 17's bacon jam. It sounds appalling, but bear with me. Firstly, it is, in fact, not a jam but an onion chutney – which straight-away makes it more conscionable. And tastewise it's actually pretty good. The mix of bacon, balsamic vinegar, onion, sugar and lemon really hits the spot when smeared on a burger. £14.44, amazon.co.uk
Top teatime
Looking for a place to go for afternoon tea? Don't head to The Ritz, carry on a bit further down Piccadilly to the Athenaeum Hotel, which has just been named the Tea Guild's Top London Afternoon Tea 2012. Apparently, it was its orange-blossom scones that won it. Sittings are at 12.30pm, 3pm and 5.30pm daily. £28.50, athenaeumhotel.comReuse content


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Belmond Governor's Residence
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... later and were told we couldn't check in until 1pm, so with 7 hours to kill we headed out to Bagan's main (only) draw, the pagodas. Options for exploring the area were bicycle, horse and cart or e-bike (electric scooters). We had initially planned on getting bicycles but seeing the distances we would be covering in the crazy heat made me quickly get over my fear of motorised bikes. This fear stems a stupid scooter crash a few years ago, but somehow the e-bikes seemed more user ...
Magical Myanmar
... properly understood who I was in relation to him but he and Maeva are very sweet kids and excited to have us round to stay nonetheless. They didn't hang around in offering up word perfect karaoke to One Direction in the car journey that night too- what a treat. These kids have equally good voices and memories it seems!
Despite still being home to some of Myanmar's official buildings and business, being easily the most important centre of trade and by far the largest city in ...
Bago, the Ancient Capital, Home of Many Buddhas
... the political prisoners, forced labour, ethnic cleansing and it has been named the fifth most corrupt nation in the world by Transparency International. At this point in time I would not want to be traveling independently in Burma, but I feel pretty safe (and welcomed) traveling in our excursion group.
I booked all of the excursions prior to the start of the cruise as I did not want to take a chance of an excursion being sold out. I realized I did ...
And we are off.........
... Market which was filled with everything from gems and Jade to puppies and vegetables….. It really was bling central… the usual sellers complete with signs indicating they accept Yen and Roubles and USD! We stopped for some refreshment (which mum managed to escape) of Tham noodle soup with a duck egg thrown in for luck, topped off by green tea that was generally available to all in rinsed out cups. I can only hope that in all my time travelling I have built up ...


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
the incident happen 6months ago. its her word against mine.
Hopefully, you have consulted with either a civilian lawyer who handles military criminal defense or with the area defense counsel. Sexual assault is a hot button issue in the military these days.
Answers on Avvo are for general information purposes only and should not be relied upon as legal advice. No attorney / client relationship is created by providing this answer. For specific advice about your situation, you should consult a competent attorney of your choosing.
Please tall me that you've consulted with JAG defense counsel.
In no way am I offering you legal advice, and in no way has my comment created an attorney-client relationship. You are not to rely upon my note above in any way, but insted need to sit down with counsel and share all relevant facts before receiving fully-informed legal advice. If you want to be completely sure of your rights, you must sit down with an experienced criminal defense attorney to be fully aware of your rights.
Depending on where she says the alleged adult occurred, that is type of lawyer you should consult. If she alleges it happened on base, or at some other military installation, then find a lawyer who knows military defense. Otherwise, if she alleges it occurred off base, then you may need to find a good state criminal defense attorney. Jurisdiction will be key initially.
Right now you are only being accused, not charged. Do not discuss the issue with anyone without a lawyer present. Do not take this lightly. "Her word" could be enough to send you to prison. The answers on this forum are broad, you need to consult with a lawyer so they can give you advice specific to your case.
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text: This business is under new management an is now operating as Drunken Joe's. This place is a nightmare as we had to wait approx 1hr 30mins for food...service was terrible...the food tasted AWEFUL and they are quite expensive. An they do not accept linx or creditcard only cash. I wil not recommend or go there again


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Zents Paper Salt
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so relaxingThese are wonderful for a nice relaxing bath. The smell is wonderful and they left my skin feeling great! — 9 years agoneelyann | 4 reviews
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Submitted by Ca_Vermonster on Tue, 2011-10-18 15:23.
As soon as I saw this photo, I said it had to be a Maine buck! That thing is a brute!!!! great looking deer. My Uncle got a 252 lb (dressed) 8 point up there one year, and I found a dead 12 point back in the 80's that would probably have pushed 240. Some great animals!


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Through 37 games, the Chicago White Sox sit only four games out of first and a half game out of the second wild card spot. Sure, there are still 125 games left in the season, but the Sox are in contention. If May standings mattered, then the Kansas City Royals would have won the last three AL Central titles. Still, it brings up an interesting question: what should the White Sox do if they are in contention come the July 31 non-waiver trade deadline?
In what is considered year one of a full rebuilding plan that GM Rick Hahn is overseeing, contending would be an added bonus. Unlike that team from the north side of town, the Sox have showed an ability to compete, while infusing players without much major league experience.
With 27-year-old Jose Abreu being the center of this movement, one could deem it an "accelerated rebuild". Still, the Sox' ability to be competitive during this overhaul of their roster should be applauded.
Winning draws attention to a ball club. With attention comes expectations. The expectation now from some White Sox fans is that they want the team to win at all costs. To do this, holes need to be filled through trades come the deadline at the end of July. If Hahn were to do this, it would be like Dorothy not following the yellow brick road in the movie Wizard of Oz.
The plan has been drawn up: continue to add and groom young talent in order to compete for the long term. If the Sox looked to upgrade at second base or add a veteran arm to the rotation for a playoff run, they would be doing it at the expense of the future. In order to add a rental player, the Sox would have to deal someone who they see as part of their future. Hahn does not want to be like his predecessor Kenny Williams. White Sox fans do not want Hahn to be like Williams in a sense that he would upgrade the present without much concern for the future.
That all being said, Hahn should not remain silent before the deadline. If someone wants to trade prospects with upside for Gordon Beckham, Hahn should pull the trigger. If a team envisions Matt Lindstrom as a veteran arm who could stabilize the back of their bullpen, Hahn should not think twice and send the closer on his merry way.
Keeping the core intact, no matter what, would be what is best for the White Sox. Competing for a decade is much more important than competing for one year.


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Scruff founder Johnny Skandros spoke to HuffPost Live about the resurgence of beards and other facial hair within the gay popularity.
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Beards are back in fashion around the world. To be sure, beards have gone through many fashions. Just think of the handlebar mustaches of the 19th century, the clone look of the 1970s or the permanent growth fancied by the bear community. But I think this time is different.
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Via Phone, Inc Overview
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1257 Oakmead Parkway, Suite A
Sunnyvale, CA 94085
Gary Seid, D.D.S. is happy to be an experienced Sunnyvale area Britesmile® teeth whitening dentist. Our patients appreciate the short amount of time the tooth whitening treatment takes. They also love the stunning results.
You can relax in our comfortable atmosphere. In just about an hour, your bright white smile will be ready to show off!
If you're looking for dentures that look great and last, look no further than Gary L. Seid, D.D.S located in the Sunnyvale, CA area. Gary Seid, D.D.S. will assess your needs and fit you with durable, comfortable, natural-looking dentures - at a price you can afford.
If you have older dentures or think you may need dentures, you're in luck. As people age, dentures can make them look older than they really are and can cause discomfort when chewing. Sunnyvale area dentures dentist Dr. Gary Seid can replace worn out dentures with top quality custom made, state-of-the-art dentures that blend with your skin, hair and even eye color. Your new dentures will look as natural as possible, and you'll look and feel younger, too.
Sunnyvale area dentist Dr. Gary Seid specializes in second opinions. Dr. Seid views second opinions as an educational experience, and highly encourages your questions about any procedure recommended to you by another dentist.
Second opinions will likely increase your overall comfort level as you gather and compare the necessary pieces of information and are able to make an informed decision.
Gary Seid, D.D.S. is proud to be a trusted Sunnyvale area Zoom!® teeth whitening dentist. Our patients love the short amount of time the tooth whitening treatment takes as much as they love the results.
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990 West Fremont Avenue Suite O
Sunnyvale, CA 94087
Dental bonding in the Sunnyvale area is available from experienced dentist Ronald Matsuura, D.D.S.. If your teeth have unsightly cracks or discoloration, dental bonding can help.
It's a quick and non-invasive procedure that corrects minor cosmetic flaws and restores your natural smile. You'll feel great being able to show your natural again.
Friendly, caring family dentistry in the Sunnyvale, California area is available at Ronald Matsuura DDS. Our team strives to make you and your family feel comfortable during your appointment. Ronald Matsuura, D.D.S. wants to help you and your family maintain your oral health now and for years to come. You'll love visiting our comfortable setting where personalized customer service still matters.
If you are missing one or more teeth, you'll want to talk with Sunnyvale area dental implant dentist Dr. Ronald Matsuura about replacements that look and feel as natural as your own teeth. If dentures are causing you problems, you may consider dental implants. Unlike dentures, which can be removed, Dr. Matsuura offers dental implants that are permanently anchored into the jaw itself.
You're unique, and you deserve quality, individualized care. Dr. Ronald Matsuura believes your dental experience should blend the best of the personal and the professional. At Ronald Matsuura DDS in the Sunnyvale, California area, we take the time to get to know you and understand your dental needs. Dr. Matsuura and his staff are dedicated to providing you with top-quality dental care designed exclusively for you.
For comfortable dental hygiene treatment in the Sunnyvale, California area, Dr. Ronald Matsuura is known for having a gentle touch. The friendly team at Ronald Matsuura DDS provides teeth cleaning for a whiter smile.
Maintaining good dental hygiene is the foundation for healthy teeth and gums. We're committed to helping you have a lifetime of oral health.
Hafez, Abeer A D.D.S.
1104 N Chinowth St
Visalia, CA, 93291-4113
Center For Microdentistry
2780 State St # 11
Santa Barbara, CA, 93105-5528
Shinkwin, Gregory E D.D.S.
1130 Coffee Rd # 4
Modesto, CA, 95355-4228
Signature Specialists
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San Clemente, CA, 92672-4802
Orthodox cosmetic teeth Laguna Hills
Black teeth whitening dentist Stillwater 74074
A general dentist attends four years of dental school after college and receives training in all areas of dentistry, including fillings, crowns, cleaning teeth, root canals, extracting teeth and much more. At the completion of this training period, a dentist can either go out and open a dental practice or continue on with their education and specialize in any of the above-mentioned areas. For example, an orthodontist is a specialist in braces.
A prosthodontist is a specialist in the restoration and replacement of broken and missing teeth. Their additional training lasts three years. During that time, they are taught in greater detail about both removable and fixed prosthodontics.
Removable Prosthodontics includes replacing missing teeth with appliances that the patients themselves can take in and out of their mouth, such as dentures and partial dentures.
Fixed prosthodontics includes replacing missing and/or broken teeth with restorations that the patient cannot take in and out, such as veneers, dental crowns, bridges and implants.
The most important part of the training is how to restore teeth in a variety of different situations so that the end result is the most esthetic and predictable outcome possible. The types of cases seen in cosmetic dentistry are often more comprehensive and complex in nature. They often involve the combination of crowns and implants or can even be as involved as placing crowns on every tooth in a person's mouth.
To do this, prosthodontists are trained to evaluate all the different aspects of your teeth and mouth. They observe and treat your mouth with regards to:
By evaluating these different areas, the prosthodontist can treat one area of your mouth, but also will determine how other areas will impact the treatment. In essence, a prosthodontist looks at your mouth as a whole, even though there may be only one tooth requiring treatment.
Often times, especially in cases involving multiple and/or missing teeth, the involvement of other specialists and cosmetic dentistry will be needed to help with treatment. These specialists include orthodontists (to straighten or move teeth using braces), periodontists (for gum surgeries and placement of implants), endodontists (root canals) and oral surgeons (for the extraction of teeth and placement of implants). In essence, the prosthodontist acts as the coordinator to help sequence the proper treatment before the final restorations are placed. Often times, treatment can take longer to complete, especially if other specialists are involved. In taking a complete approach, you can be assured that you will end up with the most esthetic and reliable treatment, whether it involves one or all of your teeth.
By Greggory Kinzer, DDS, MSD
If you require a dental crown to be placed, it is a good idea to talk to your cosmetic dentist about how you feel about the color of your existing teeth before beginning the process. If you like the color of your teeth, your cosmetic dentist will then find a color that matches the crowns.
On the other hand, teeth bleaching may be an option for you. If you feel you would like to whiten or lighten your teeth, it is a good idea to communicate this to your cosmetic dentist beforehand. Once the final restorations are made, it will not be possible to change their color without redoing them.
If you desire whiter teeth before the cosmetic crowns are placed, the best way to achieve this is to talk to your cosmetic dentist about at-home teeth bleaching. With this procedure, custom-fitted plastic trays will be made for your teeth and you will be given some small tubes of teeth bleaching material.
Your cosmetic dentist will show you how to place a small amount of teeth bleaching material in the tray and then place the tray in your mouth. If any excess material squirts out of the tray onto your gums, you will want to remove it with your finger or a toothbrush.
The tray is then worn for one to two hours in the evening, depending on the type of teeth bleaching material. The biggest advantage of this method of teeth bleaching as compared with procedures that are done in your cosmetic dentist's office is that you are the one that can control how white you want your teeth to be.
Since you are the one in control, you can stop the teeth bleaching whenever you feel you have achieved the desired color. The typical teeth bleaching time is one and one-half to two weeks, but it may be longer.
You may experience that your teeth become sensitive to cold air or liquids during the teeth bleaching process. This is normal and will subside and finally go away when you stop the teeth bleaching.
There are a couple of things you can do to decrease this sensitivity if it arises during the teeth bleaching process. One is to only bleach every other night. By taking a break after each night of teeth bleaching, your teeth will not be as sensitive.
The other is to have your cosmetic dentist prescribe you a fluoride gel that you can place in your custom teeth bleaching trays every other evening. The fluoride acts to decrease the sensitivity by coating or sealing the tooth surface and it will not affect the color of your teeth. This is the most reliable way to decrease sensitivity while you bleach.
Once you get your teeth to the desired color , your cosmetic dentist will have you wait about three to four weeks before taking a color match of your teeth in order to make the final restoration. During this time, the color of your teeth is stabilizing.
Teeth bleaching is very predictable, but the results will not last forever. Since the restorations were placed when your teeth were at their whitest, you will most likely find that in one and one-half to two years, the restorations may begin to appear lighter than your natural teeth.
This result is to be expected. It is not caused by a change in color of the restorations, but rather by your own teeth getting darker. At this point, all that is required is to, once again, bleach your natural teeth until the color is evened out. Usually, this only requires teeth bleaching a couple of times.
After the color is evened out, you can then expect to have the color stability last for another one and one-half to two years. On the other hand, if no restorations were placed by your cosmetic dentist after your teeth bleaching, you will most likely not notice the teeth changing color because there is no reference to help judge this change.
By Greggory Kinzer, DDS, MSD


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Top Definition
A young male, generally from pre-pubescent to adolescent stage, who displays exceptional intelligence and/or handiness with electronics and science. This is the most common type of young genius and is distinguished by using their inventions, usually death rays or attack robots, for wrongdoing.
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The Sleepwalker
Book 9 Unabridged [CD-Audio/MP3 Edition]
By (author) Robert Muchamore
Read by Julian Rhind-Tutt
Format: CD-Audio
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Sleepwalker by Robert Muchamore
Book Awards
Book DescriptionAn airliner explodes over the Atlantic leaving 345 people dead. Crash investigators suspect terrorism, but they're getting nowhere. A distressed twelve-year-old calls a police hotline and blames his father for the explosion. It could be a breakthrough, but there's no hard evidence and the boy has a history of violence and emotional problems. Only CHERUB agents can unearth the truth. They're trained professionals with one essential advantage: adults never suspect that children are spying on them. For official purposes, these children do not exist.
Buy Sleepwalker book by Robert Muchamore from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9781844568246
(142mm x 125mm x 24mm)
Pages: 220
Imprint: Hodder Children's Books
Publisher: Hachette Children's Group
Publish Date: 16-Oct-2008
Country of Publication: United Kingdom
Other Editions...
Books By Author Robert Muchamore
Class A: The Graphic Novel, Paperback (June 2017)
Experience the second CHERUB international bestseller in graphic novel format! James Adams' mission is to succeed where dozens of attempts by undercover police officers have failed ...
New Guard, Paperback (June 2017)
The last CHERUB book ever sees new CHERUB agents like Ryan Sharma up against the old guard, including James Adams, in the mission to end all missions!
Gone Wild, Paperback (February 2017)View all books by Robert Muchamore
Who will win? Find out in the third title of this action-packed series from international bestseller Robert Muchamore.
» Have you read this book? We'd like to know what you think about it - write a review about Sleepwalker book by Robert Muchamore and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Robert Muchamore
Robert Muchamore was born in Islington in 1972 and spent thirteen years working as a private investigator. He was inspired to create the CHERUB series by his nephews' complaints about the lack of anything for them to read!
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text:
Research interests:
Fundamental physical and inorganic chemistry: Laws of thermodynamics and quantum mechanics applied to chemical problems of importance.
Protein science and theoretical biochemistry: The structure, dynamics, function, and natural evolution of proteins.
Applications: To identify the molecular causes of neurological diseases such as Alzheimer's Disease and ALS, to define new therapeutic strategies, and use "rational evolution" to invent new efficient enzymes for industrial purposes.
2016: The Loss of Function theory of Alzheimer's Disease.
2016: The gate-plug mechanism whereby mutations in presenilin 1 cause Alzheimer's Disease: Loss of hydrophobic packing and stability in the membrane reduces cleavage accuracy and function. The properties can be correlated directly to clinical severity of PSEN1 variants.
2016: Protein stability effects are universal and can predict stabilities of protein variants relevant to protein engineering and evolution.
2015: The structure of β-amyloid in best agreement with available experimental data, from comparison of 21 force field methods.
2015: The Energy Theory of Neurodegeneration. Neurodegeneration in ALS can be shown to be due, not to a specific toxic molecular mdoe of protein aggregation but to systemic energy burden of protein turonover. This increased energy cost correlates directly with patient data and explain many features of ALS not previously explained, including why protein misfolding causes disease specifically in neurons, the most energy-demanding cells of the body.
2015: The molecular features of β-amyloid that cause toxicity. Specific conformational features and exposed parts of the peptides explain the experimental toxicities of different peptide variants. These features can now be targeted by molecular intervention.
MAIN EARLY DISCOVERIES 2003-2009 (all as first author):
2003: Explaining molecular co-evolution of metal ions and tetrapyrrole cofactors from thermodynamic stability and function (with U. Ryde).
2004: The broad crossing mechanism of ligand binding to heme, explaining how molecular evolution of close-lying spin states in heme allows fast reversible binding of dioxygen crucial to life (with U. Ryde).
2005: O2 binding to heme is the basis of higher life forms on this planet, but the process has been debated for 50 years. We did the first high-level calculation of this problem (multistate CASPT2), to answer the old question about the relative contributions of Pauling, Weiss, and Goddard / McClure resonance forms (with Björn Roos & Ulf Ryde).
2005: Our mechanism of how the Co-C bond is cleaved in B12-dependent enzymes. QM/MM simulations show that the Ado radical is stabilized by electrostatic interactions and the Co(III) ground state is distorted. Both effects (product stabilization and reactant destabilization) contribute (with U. Ryde).
2006: OPLS-2006 force field: First co-parameterization of anions and cations of salts for use in molecular simulation, to make free-energy consistent salt solutions critical to molecular simulation (with W. L. Jorgensen).
2008: OPLS-2008 force field: First demonstration of the water model --- protein force field interdependence that affects most protein simulations and two specifically parametrized OPLS force fields for charged residues, one for TIP3P water and one for TIP4P water.
2008-2009: It was shown by benchmarking against various experimental data that the density functional method TPSSh by Tao, Perdew, and co-workers, is a very accurate functional for inorganic chemistry vs. normally used functionals.
|Jul 2016. Kasper speaks at the
conference in Nanjing, China, on our
findings in heme biochemistry.
|Jun 2016. Loss
of function in Alzheimer's Disease. A
comprehensive new theory of this terrible disease
that explains current failures of treatment and
solves biochemical inconsistencies.
|Apr 2016. Protein stability effects are universal and can predict stabilities of protein variants relevant to protein engineering and evolution.
|Feb 2016. The general mess of Aβ. New
meta-analysis shows no relationship between
widely studied cell and mouse data and clinical
outcome, i.e. these models do not reflect the aging
human brain's AD.
|Sep 2015. The quest for the structure of β-amyloid (new work published in ChemPhysChem)
|Aug 2015. Speaking at the ECOSTBio meeting
in Belgrade, Aug 24-25.
|July 2015. Speaking at the ICCB conference in Kauai, Hawaii, July 2 to 6.
|June 2015. EMBO neuro- degeneration meeting in Heidelberg June 14-17.
|March 2015. Molecular Causes of ALS: Coupling protein energy to real patient data.
|Feb 2015. New mechanism of laccase inhibition: impairing reorganization energies.
|Nov 2014. New patent WO2014167112 for synthesizing sugars
|Nov 2014. First relation between real patient data and biochemical properties of genetic variants causing Alzheimer's disease
|Oct 2014. Søren Brander successfully defends his Ph.D. thesis. Congratulations!
|Sep 2014. Arun joins our group as a ph.d. student to work on proteins involved in Alzheimer's disease.
|Dec 2013. Kasper joins the Management commitee of the EU-sponsored COST action on spin states in biochemistry and technology
|Jun 2013. Pouria Dasmeh successfully defends his Ph.D. thesis. Congratulations!
|Dec 2012. Our research is described in the Danish newspaper Politiken.
|Oct 2012. New review in Chemical Reviews on "Bioinorganic Chemistry of Alzheimer's Disease"
|Sep 2012. Kasper speaks as invited speaker at teh CECAM workshop in Zaragoza, Sep 18-21.
|Aug 2012. New review on theoretical inorganic chemistry: "Consistent descriptions of metal–ligand bonds and spin-crossover in inorganic chemistry"
|Copyright 2014. Kasper P. Kepp.


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Strapping Tools and Parts carries a complete range of strapping, strapping tools, strapping accessories, and strapping machines. Our stocked industrial strapping supplies include steel strapping, poly strapping, plastic strapping, and polyester strapping, as well as strapping seals for steel and strapping seals for poly. In addition to an extensive line of strapping supplies, Strapping Tools and Parts offers a range of steel strapping strapping tools, metal strapping tools, poly strapping tools, and polyester strapping tools from leading strapping manufacturers including Signode strapping tools, Fromm banding tools, MIP strapping tools, Cyklop International strapping tools, and Samuel strapping tools, to name just a few. We can help you design your packaging line, furnish your operation with quality strapping machines, as well as provide excellent service and tool repair. Strapping Tools and Parts opened its doors in Greenville, SC in 1976, and has since expanded its locations to Orangeburg, SC, Greensboro, NC, Charlotte, NC, Memphis, TN, Lakeland, FL, and Eastvale, CA. Because of strong vendor relations, we can guarantee reliable, durable, high quality strapping products and strapping systems that improve your packaging, protect your product, and increase your profits by reducing damage and improving productivity.
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This morning I went to the oral surgeon to have my four wisdom teeth pulled. The procedure was painless because they knocked me out with some general anaesthesia. The last time I had general anaesthesia, 15 years ago for a knee injury, I woke up crying and mumbling, "I don't want to die, I don't want to die." I felt as if I was being pulled out of a black hole. So, you can probably imagine my relief this time when I gently awoke to the nurse's soft voice asking me to sit up. No death fear, no black hole. Just some swelling, a little woozy feeling, and a pain in the back of my mouth—nothing that a vicoden and another nap won't take care of. Sweet dreams.
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Bush® Cubix® Collection 3-Drawer Mobile Pedestal File Cabinet; Hansen Cherry, Lttr/Lgl/A4 (WC94453)
Item # 901-WC94453
Model # WC94453
Bush Cubix Collection file cabinet has casters for easy portability Add a mobile file cabinet to your Bush desk system with this Bush Cubix Collection file cabinet. Made of durable thermally fused laminate, this mobile file pedestal is finished in Hansen cherry to complement your existing office furniture. The smooth-gliding casters make movement easy, and the lower file drawer features a secure lock that keeps your files safe and confidential. Store office supplies and files in this rugged Bush file cabinet.
- Two box drawers and one file drawer accommodates your office supplies and letter, legal or A4 size files
- Made of dark cherry colored thermally fused laminate
- Dimensions measure 15.70" W x 20.15" D x 27.87" H
- File cabinet feature a durable lock for security
- Meets ANSI and BIFMA standards for quality and safety
- Made in the USA and GSA approved for quality
- Easy gliding casters make movement convenient
- Easy assembly required
|Product Information
|File Cabinet Type :
|Mobile/Pedestal File
|Furnishing Color :
|Number of File Drawers :
|File Size :
|Fire Resistant :
|Not Fire Resistant
|Furnishing Material :
|File Cabinet Assembly :
|Assembly required
|Warranty Information :
|10 Years
|General Information
|True Color :
|Brand :
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|61.00 lbs. per Each
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text:
This lesson will define, discuss and examine Rogers' Self Theory and its components.
Emphasizes current, subjective understanding; self-concept, real self, ideal self.
True representation of the person we are.
Internalizes standards of judgments that evaluate our behavior, emotions, and thoughts.
Our total perception of ourselves; mental picture based on our perception (positive and negative) of our traits, behaviors, abilities.
Who we would like to be.
Person who strives to live in harmony with their present impulses and feelings.
Congruence of ideal self, real self, and self-concept.
Parts of self are in alignment and balanced.
Inaccurate self-image; self-image differs from the ideal self.
External and internal conditions necessary for a person to become fully functioning; lower needs must be met prior to higher needs, but higher needs must be met for a fulfilling life.


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Back Bay Golf Course
Newport Beach Golf Course and Event Destination
Attend a meeting in the morning and squeeze in nine holes at the Back Bay Golf Course. This par-3 Newport Beach golf course is perfect for improving your short game. Carved out of Newport's Back Bay area, the executive course offers breathtaking scenery and 9 challenging holes. Start your Southern California golf vacation at Hyatt Regency Newport Beach, where green fees are included for up to 2 adults per room daily with your resort fee.
If you're attending a wedding, meeting or team building retreat near the Hyatt Regency Newport beach, spend a beautiful afternoon teeing off at Back Bay Golf Course. With views of the Upper Newport Bay, this spectacular 9-hole course is the perfect getaway to hit the greens with your family, friends, and colleagues. The hotel can even arrange creative food and beverage stations at each hole for an active and fun team building event or a progressive reception for corporate groups.
- 9-hole executive golf course
- Spectacular Upper Back Bay views
- Night golf with glow in the dark balls can be arranged
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- Hours: dusk 'til dawn
For more information, or to schedule a tee time, please call 949-729-6193.
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text:
16 Attending
2 Attending
1 Attending
5 Attending
Mon, 24 Oct 2016
26 comments
Deadly drum n bass from one of the genre's finest DJs.
9 comments
8 comments
22 comments
Sat, 7 May 2016
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The LP, made under the name Kovsh in the late '90s and '00s, is out on Convex Industries.
Sat, 2 Apr 2016
10 comments
New releases come from Homemade Weapons, Clarity and Nucleus & Paradox.
Thu, 5 Nov 2015
2 comments
Cosmic Bridge's second compilation features new tracks from DJ Madd, Moresounds and Danny Scrilla.
Tue, 6 Oct 2015
Chrissy, Dylan and Homemade Weapons are booked for this weekend's anniversary celebration.
Wed, 15 Apr 2015
3 comments
Pinch, DJ Hype and Bad Company UK are also among the Croatian event's new additions.
Mon, 23 Feb 2015
9 comments
Illustrations features new tracks from dBridge, Clarity, Skeptical and more.
Tue, 2 Dec 2014
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Calibre, Ital Tek, Loxy and more feature on the new 24-track box set from 31 Recordings.
Fri, 7 Nov 2014
The DC nightclub has shared its schedule through mid-December.


text:
The End of Empire in French West Africa
France's Successful Decolonization
By (author) Tony Chafer
Format: Paperback
Normal Price: $45.00
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End of Empire in French West Africa by Tony Chafer
Book DescriptionIn an effort to restore its world-power status after the humiliation of defeat and occupation, France was eager to maintain its overseas empire at the end of the Second World War. Yet just fifteen years later France had decolonized, and by 1960 only a few small island territories remained under French control.The process of decolonization in Indochina and Algeria has been widely studied, but much less has been written about decolonization in France's largest colony, French West Africa. Here, the French approach was regarded as exemplary -- that is, a smooth transition successfully managed by well intentioned French politicians and enlightened African leaders. Overturning this received wisdom, Chafer argues that the rapid unfurling of events after the Second World War was a complex , piecemeal and unpredictable process, resulting in a 'successful decolonization' that was achieved largely by accident. At independence, the winners assumed the reins of political power, while the losers were often repressed, imprisoned or silenced.This important book challenges the traditional dichotomy between 'imperial' and 'colonial' history and will be of interest to students of imperial and French history, politics and international relations, development and post-colonial studies.
Buy End of Empire in French West Africa book by Tony Chafer from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9781859735572
(216mm x 140mm x 15mm)
Pages: 288
Imprint: Berg Publishers
Publisher: Bloomsbury Publishing PLC
Publish Date: 1-Jun-2002
Country of Publication: United Kingdom
Other Editions...
Books By Author Tony Chafer
Francophone Africa at Fifty, Hardback (November 2013)
Explores the complexities of France's role in Africa over the past century
From Rivalry to Partnership?, Hardback (July 2011)
Evaluates the significance and strength of the emerging Anglo-French partnership and explores how far this and other forms of 'bilateral' and 'bi-multi' cooperation might serve as an alternative or complement to traditional unilateral and multilateral approaches in Africa.
End of the French Exception?, Hardback (May 2010)» View all books by Tony Chafer
Analyzes the notion of the French exception and the ways in which it has informed both academic analysis and political commentary on France today. Adopting a comparative and interdisciplinary approach it examines the resilience of the notion of French exceptionalism and evaluates its relevance in a changing domestic and global context.
» Have you read this book? We'd like to know what you think about it - write a review about End of Empire in French West Africa book by Tony Chafer and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a member - it's free to sign up!)
Author Biography - Tony Chafer
Tony Chafer Principal Lecturer in French and African Studies,University of Portsmouth
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australian fashion milk from a thistle
Always a favourite of mine, Milk From A Thistle know how to do amazing animal prints! Th...
Always a favourite of mine, Milk From A Thistle know how to do amazing animal prints! This season features the 'Birdhouse' and 'Fox Field' digital silk prints along with pop-bright colours and classic stripes to mix and match in the warmer months.
Milk From A Thistle is also proudly designed and made in Australia.
View the current collection here.
11 comments
I didn't notice the fox, until I read the name! Adorable x100ReplyDelete
that birds print is AMAZING!ReplyDelete
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Love that second. Very rad indeed! Amy xReplyDelete
Wow I love these prints they are beautiful and the colour are great and especially relevant!ReplyDelete
What a gorgeous brand and collection!ReplyDelete
Love that first dress and that bird-top
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omg, love these prints! Beautiful colours ♥ReplyDelete
I love the third dress!ReplyDelete
i always love their stuff!!ReplyDelete
The birds print on the shirt is amazing i Love this !ReplyDelete