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Self-catering restored Georgian house - private, peaceful and fully-equipped
No visitor to the house fails to appreciate the painstaking time and effort that has gone into restoring this residence to its original splendour. From the artfully refurbished original floorboards to the magnificent nineteenth century iron bath, this tastefully restored Georgian residence is a real treat to anyone looking for a refreshing and authentic alternative to the sterile and characterless accommodation so prevalent today. No expense has been spared in combining the original character with all the comfort and trappings of modern convenience. Three of the four bedrooms are en-suite while the kitchen comes equipped with an array of accessories. All that you could possibly need to make your stay both restive and restorative is included.
The house is situated in the very heart of the beautiful village of Kinnitty, nestled at the foot of the Slieve Bloom Mountains. Magnificent walking trails are at your door while the Shannon river is close, for quality fishing and sailing
Setting: The private and spacious environs are the perfect compliment to the authentic charm and beauty of the tastefully restored Georgian residence. Through double doors, the soothing sounds of the passing river offer those relaxing on the patio a chance to savour the rugged beauty of the majestic Slieve Bloom mountains. This idyllic setting will be perfect for any couple enjoying the vista of the retreating sun or indeed for any family enjoying the space and sanctuary of the private garden.
On your doorstep: Take a step outside and find yourself in the very heart of the beautiful village of Kinnitty, nestled at the foot of the Slieve Blooms. Take a stroll through the centre or stop at the 'Slieve Bloom Bar', where live music is often found or at the Black and White award-winning pub 'Clendenings' where a turf fire and a friendly welcome is guaranteed. A pleasant walk East of the village will bring you to the world famous Kinnitty Castle where all the opulence and luxury of the original castle is combined with a host of activities from equestrian trips to mountain hikes to Falconry.
Lots to do and see: The sheer range of activities available is astonishing. From falconry to fishing,hill-walking to water sports, there is something for everyone. Enjoy the music and atmosphere in the local pubs or take in some of the native Irish field sports played in the area. Walk through the heart of the Bog of Allen and admire the extraordinary sculptures in Lough Boora parklands. Stroll around the heritage town of Birr where the award-winning Birr Castle Demense Gardens can be found. Take a boat on the Shannon down to Lough Derg to fish or simply relax and enjoy the stunning scenery. Marvel at the immaculately preserved Monastic ruins at Clonmacnoise. Catch one of the many festivals or explore the mountains on your doorstep with the local club. Truly, you won't be bored.
Top Traveller Review
Home with Ireland character!!! Очень рекоммендуем всем!
The house has everything you might need. It's located in the middle of the country and you can visit as many places as you want and enjoy the real country side of the Ireland.
We are naturally Russians and would love to say few words in Russian for a future Russian tourists.
Дорогие друзья, наши соотечественники, если Вы решили посетить Ирландию и ищете подходящий дом, где остановиться, Киннити, близ Биорра, это самое подходящее место. Дом находиться в самом центре страны, так-что можно посетить много различных мест, арендуя один дом.
В доме много комнат и ванных комнат. Для большой семьи или большой компании этот дом может быть лучший выбор.
Ирландский бар рядом с домом. Если вы любите выпить и посмотреть как это делают ирландцы то за руль садиться не надо. Дом, который вы будете арендовать прямо за углом.
Хорошая цена и хорошее качество. Хозяин очень дружелюбный и живет недалеко, всегда может помочь если что надо.
Очень рекоммендуем всем!
About the Owner
26 Reviews
4.8/5 -
(26 traveller reviews)
A lovely, warm and comfortable house.
This house was the perfect location for us as our son was getting married in Kinnitty Castle on 24th November. We were staying in the Castle for two nights for the wedding and needed somewhere to stay the few days before and a few days after the wedding so we rented the house for a week.
Flying in to Dublin from the UK we rented a car at the airport and following the instructions from Connor O'Brien we found the house easily. Mr. Jimmy O'Brien was there to greet us and let us into the house. What could be more welcoming on a bitter cold November afternoon than a roaring fire? Yes Jimmy had one burning for us. The house was lovely. Larger than we expected and provided everything we needed. After exchanging pleasantries and letting us look over the house Jimmy left us to it after assuring us he was just next door should we need anything. With a basket of logs and a garage full of turf for the fire and central heating we were certainly not going to be cold.
A trip to the local "newsagent" where the owner, Michael, was a joy to meet, provided us with everything we needed. Milk, coffee, eggs , bacon, sausage, mushrooms etc. He stocks almost everything.
The house was just perfect. Plenty of room, 4 bathrooms, 5 toilets, a constant supply of hot water, a kitchen large enough to dance in and all the pots, pans and utensils etc you could possibly need.
As we were in Ireland for the purpose of the wedding we did not get time for sight seeing which gives us an excuse to return and we would definately return to this house. It was lovely.
Home with Ireland character!!! Очень рекоммендуем всем!
We loved our stay in Ireland! The owner is a very nice man. He is nearby and always ready to help.
The house has everything you might need. It's located in the middle of the country and you can visit as many places as you want and enjoy the real country side of the Ireland.
We are naturally Russians and would love to say few words in Russian for a future Russian tourists.
Дорогие друзья, наши соотечественники, если Вы решили посетить Ирландию и ищете подходящий дом, где остановиться, Киннити, близ Биорра, это самое подходящее место. Дом находиться в самом центре страны, так-что можно посетить много различных мест, арендуя один дом.
В доме много комнат и ванных комнат. Для большой семьи или большой компании этот дом может быть лучший выбор.
Ирландский бар рядом с домом. Если вы любите выпить и посмотреть как это делают ирландцы то за руль садиться не надо. Дом, который вы будете арендовать прямо за углом.
Хорошая цена и хорошее качество. Хозяин очень дружелюбный и живет недалеко, всегда может помочь если что надо.
Очень рекоммендуем всем!
Lovely large property by the pub
Really homely place with big rooms and a really comfy fire in the living room.
Good easy to spot near lots of great walks. Great that it was by the pub (the landlord Keiran, was most really welcoming), though it quite noisy in the front bedroom, which looked out across the pub front.
A Gem of a property
Five of us stayed for 10 days in mid July. The property is great for this amount of people. Four bedrooms and five toilets is always going to be a great combination! The property was clean and well maintained and the owner is right next door to sort out any requirements that you may have that are not already taken care of. I would not hesitate to recommend this property.
This place is situated right next door to the famous Slieve Bloom Bar where often there is live traditional Irish music and you will be well looked after by Kieren the proprietor.
A great location and a great property that is good value.
Just like you imagine :)
Lovely home, perfect position for a spot of sight seeing. We were really lucky with the weather - which although was great meant we didn't get to enjoy the open fire LOL! Teenage sons liked having the bar and pool table right next door. Any time we contacted the owner the response was really quick and helpful. Wouldn't hesitate to recommend it if you're looking for a country home in a quiet village.
Comfortable home in central location
We thoroughly enjoyed this comfortable home located in the middle of Ireland. We were able to access Cork, Waterford, Galway, Dublin and Ulster easily from here as well as enjoying the local area. Great pub with a friendly staff right next door. The home was large enough to accommodate all five of us and frankly, could handle a few more. Lots of room to spread out. Recommended.
Activity and Interests
This is a wonderful base for exploring and discovering the Slieve Bloom and its Environmental Park, there are many walking trails, two equestrian centres, Kinnitty Castle Hotel, the ancient monastic site of Clommacnoise, Birr Castle Gardens and Telescope, Tullamore Dew Heritage Centre, Lough Boora Parklands, Birr Heritage Town and much more.
There are also three full Golf courses within a 20 minute drive with many more in close proximity to Kinnitty.
The Shannon river is only a 20 minute drive, while one of it's most magnificent lakes, Lough Derg, and it's array of activities, is only 35 minutes away.
Fishing is very popular in the area, both on the Shannon and its many tributaries.
Local Festivals include Birr Vintage Week (Aug), The Tullamore Show (Aug) Tullamore Phoenix Festival (July), Slieve Bloom Storytelling (October), Irish Fleadh Ceoil in Tullamore (Aug ) as well as weekly organised walking trips with the local club.
Kinnitty Castle is a centre of Irish music.
Other Activities: Birr Castle's magnificent gardens (10 min); Water sports on Lough Derg (30 min); Lough Boora bog Parklands; Kinnitty Castle; Falconry
Golf: For the golf lover, there is an abundance of golf courses in the vicinity, some within a ten minute drive and many more that are easily accessible.
Prices and Availability
Rental rates
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Event Price
4 Sep 2016 - 24 Feb 2017
3 night minimum stay
for 3 nights
25 Feb 2017 - 27 May 2017
3 night minimum stay
for 3 nights
My Standard Rate
3 night minimum stay
for 3 nights
Additional pricing information
|No additional mandatory fees
Reasonable usage of fuel is included in the rent
All electricity costs are included.
Owner's Cancellation Policy
- 12
- Available arrival
- 12
- Available
- 12
- Unavailable
Property Type
- house
- Away From It All
- Family
- Activities Guide
- Basic Soaps
- Broadband Access
- Fireplace
- Firewood
- Garage
- Heating
- Internet
- Linens Provided
- Local Activities Guide
- Local Maps
- Parking
- Toilet Paper
- Towels Provided
- Tumble Dryer
- Washing Machine
- 4 Ring Stove
- Cooking Utensils
- Dishwasher
- Freezer
- Grill
- Microwave
- Oven
- Refrigerator
- Hob
- Toaster
- Dining Area
- Books - Fiction / Non-fiction
- CD Player
- DVD Player
- Radio
- Stereo
- Television
- Long-term Renters Welcome
- children welcome
- pets considered
- suitable for elderly or infirm
- wheelchair inaccessible
Location Type
- mountain
- village
- churches
- forests
- library
- marina
- waterfalls
Leisure Activities
- bird watching
- horse riding
- scenic drives
- sight seeing
- walking
Local Services & Businesses
- fitness centre
- groceries
- medical services
Sports & Adventure Activities
- cycling
- equestrian events
- fishing
- fly fishing
- freshwater fishing
- golf
- hiking
- mountain biking
- mountain climbing
- mountaineering
- pier fishing
- swimming
- tennis
Floor Area
- 140 m²
- En-suite 1 - Toilet, Shower Enclosure
- En-suite 2 - Toilet, Shower Enclosure, en-suite
- En-suite 3 - Toilet, Shower Enclosure, en-suite
- Main Bathroom - Toilet, Bath (no shower), Restored Iron bath
- Downstairs Toilet - Toilet
- The property has four bathrooms including three en-suites as well as a downstairs toilet. The highlight is the perfectly restored original iron bath in the main bathroom.
- 4 Bedrooms, Sleeps 8
- Bedroom 1 - 1 Large Double Bed, 1 Cot, en-suite
- Bedroom 2 - 1 Large Double Bed, en-suite
- Bedroom 3 - 1 Large Double Bed, en-suite
- Bedroom 4 - 1 Large Double Bed
- Three of the bedrooms are en-suite and all are newly restored to their original elegance including original wooden floors and restored period sash windows.
- Garden
- Barbecue
- Patio
- 6 garden chairs
- Self-catering
- Free broadband access in the house while a pre-pay wireless broadband modem (dongle) is also available for tenants to take with them as they travel around Ireland. Children always welcome as are pets (as long as they're suitably house-trained!).


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$5.99 $19.99
This cute kitty duo are a fancy bunch! With a unique cat earring design, you are sure to make a cat-tastic statement. Stylish enough for even the most adventurous fashionistas, yet bathed in pure kitty simplicity, these pair of cat earrings gives admirers the illusion that you never travel alone. Made using the finest acrylic materials with a stainless steel stud, these lightweight cat earrings are designed for a comfurrtable fit. Don't go anywhere without these pearl wearing twins.
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subset: commoncrawl


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|Language Courses
Every week, we look at a different everyday English phrase or piece of slang in this fun three-minute programme. From BBC World Service
February 18th, 2013
Episode 224 of 549 episodes
Abigail tells Rob to act his age not his shoe size. But what does this mean?
You'll need to sign in to write a comment.
Welcome to the daily audio workout for your head.


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Free Beer & Hot Wings: High School Football Brawl Centers Around Special Needs Player [Video]
On Thursday night, Vincent Stover, an autistic player on the Mountain Ridge High School football team near Phoenix, entered the game against late against North Canyon.
On his first play, he was tackled pretty hard an excessively by an opposing player.
That's all it took for retaliation to happen and both benches to clear.


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This is absolute oceanfront luxury living in Phuket: This award winning residential resort combines its cutting-edge design and unique location, on a headland between two of Phuket's best beaches, with outstanding concierge-style Thai hospitality.
Ocean Loft apartments have private infinity swimming pool positioned for exceptional ocean views and wonderful sunsets. Bedroom and bathroom situated on the second floor where you can enjoy your private stunning sea view. The latest technology on a level previously unavailable in Phuket allows guests to control the space of living area through the touch of an iPad to control of lighting, temperature, music, television, blinds and service requests.
100% Italian-made kitchen is filled with digital devices, built with industrial research make home-style cooking a true pleasure. It was designed by Snaidero known as Orange, that's why here were used only environmentally-friendly materials and functions are designed to reduce energy consumption and separate waste
Kitchen is fully fitted with European appliances including De Dietrich's premium collection of smart induction hobs, stainless steel downdraft extractor hoods, ICS (Intelligent Cooking System) ovens, microwaves and built-in dishwashers designed in France; Siemens' built-in intelligent sensor refrigerators, washing machines and dryers designed in Germany; Vintec's wine cellars designed in Denmark; and an optional Swiss-designed, automated Nespresso coffee machine. Each smart appliance is seamlessly integrated from the outset, all aligned by Snaidero's original concept.
In-villa chefs along with butler-style service can be provided upon request.
Oceanfront Club House includes a bar, bistro and pool. Facilities include a luxury spa, gym, lounge and function room.
- Duck-down bedding and pillow-menu
- Nespresso coffee-machine
- Centralized Sky Villa controls for climate, shades/blinds, audio-visuals & lighting
- Oversized HD LCD televisions, excellent audio-visual system
- Free high-speed Wifi
- Interactive entertainment system, with iPod integration, via complimentary iPad
- Enormous selection of movies, Internet Radio and huge choice of music
- Interactive menu selection for villa-dining and spa treatments
- Luxury bathroom products from the world-famous Lemongrass House, Phuket
- Electronic in-room safe
- Voltage 220-240AC, 50 Hertz – with adaptors available
Award - winning Phuket luxury resort and residence and has been voted "Best Apartment in the World".


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Prior to going bankrupt, Hanjin Shipping had chartered five, 3,400-TEU vessels and eight, 10,100-TEU vessels from Danaos.
The United States Maritime Alliance, the employer group that negotiates the master contract with the International Longshoremen's Association, called the ILA's planned work stoppage threat "disturbing."
The terminal operator increased spending from $70 million to $200 million in preparation for ultra large containerships.
Registration takes less than 1 minute.
The success of a blockchain, which is essentially a specific type of database where time-stamped and authenticated digital records are compiled, is based on two foundational concepts: data immutability and the distributed nature of how data is assembled.
Forwarders and NVOs are accustomed to adapting to complex markets and new competitors, but is this time different?
While a host of technology startups have adopted Uber-like models to tackle automated freight matching in the trucking industry, in the last two months, Uber themselves and Amazon have jumped in the fray.


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Jan 25, 2016From Buyer: InsanityOne
Barra was great to work with! The communication was always quick and so was the shipping! I would not hesitate to do business with them again! Highly recommended!
Jan 6, 2016From Buyer: mohdkhamsya
Fast and responsive seller. Item in pristine condition.
Dec 21, 2015From Buyer: Hi-Fi EDU
Don't let the minimal feedback fool you. Great communication and transaction from a longtime Head-Fier. Buy with confidence.


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Chef Robs Cafe & Upscale Lounge
We are proud to offer authentic Caribbean cuisine with a gourmet twist. Celebrating Jamaican favorites as a whole, Chef Rob brings a unique, upscale casual dining restaurant to the city. Located just outside of the Perimeter, in the affluent Sandy Springs area, Chef Rob's Caribbean Cafe is a must for those looking for a cultural atmosphere without sacrificing taste and a proper dining experience. Make your reservation with us today.


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Rates in SGD (taxes & fees included), shown as:
Nightly Average
Palace Hotel Hvar
'Trg Sv. Stjepana BB Dolac BB, Hvar, Croatia', 'Central', Hvar '21450', Croatia
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Palace Hotel Hvar Hotel Reviews
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Palace Hotel Hvar Hotel Details
Check-in: 14:00
Check-out: 12:00
Perfectly Located In Hvaras Main Square Offering Amazing Views, Old-Time Charm Full Of History, Comfortable Rooms And Friendly Staff.the Palace Offers A Range Of Rooms And Suites To Meet The Needs And Preferences Of Its Guests, You Can Choose From Distinct Views Of The Sea, City Or Fortress. The Rooms At The Palace Have Been Equipped With Hair Dryer, Satellite Lcd Tv, Cribs Available On Request, Mini Bar, Complimentary Toiletries And *free Wi-Fi Internet Access In The Lobby Allowing Guests To Thoroughly Enjoy All The Natural Charm And Beauty Of This Historic Hotel.
'Trg Sv. Stjepana BB Dolac BB, Hvar, Croatia', 'Central' Hvar '21450', Croatia


text: OK, it's now about three years after I first started lurking around SA and one year into my retirement. Thanks to getting heavily back into the market in 2009 and jumping into the world of high div and high div growth stocks (MLPs, REITs, BDCs, CEFs, and some of the 4+% big cap div growth stocks), I can afford a few speculative trades now and then. My timing was perfect with early to mid 2009 as a major entry point for me for 90% of my portfolio. However, my speculative trades and channel trades have not worked out so well timing wise, but I keep these trades to 5-10% of the total investment portfolio. Currently, working on techniques to minimize risks to income from investments while minimizing the time required to maintain the stocks in the portfolio. Investment income and a pension from a high-tech company are more than enough to support my wife and I at 57 and 62 years, respectively, and we've decided not to draw social security early. I continue to think SA is one of the best avenues around for learning and sharing about investing, and encourage everyone to always do their own DD. May one day become a contributor.


text: With several pizza choices in Montauk, this by far is the best (recommended by my friend, who lives in the area). Best veggie pie I have ever had - nice thin crust, flavorful sauce and tons of veggies. The eggplant pie is awesome too! Only pizza place we ever go to when in town.


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Location: Ireland
Member Since: October 2010
Open for read requests: Yes
Short Story / Non-Fiction
Poem / Poetry
Poem / Poetry
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1. How would you rate your thanksgiving dinner?
Surprisingly good! I tried a new method for the turkey, and it was fall-off-the-bone tender. The butternut squash and apple casserole was especially yummy (I'll post that recipe later...it's healthy!).
2. Did anyone come that you wish didnt?
3. How many people showed up, and how many were you expecting?
My mom had the flu, so she asked if I would mind if we didn't do Thanksgiving dinner this year. So, it was just myself and the two avians (unless you count the 10,000 people who ran the Turkey Trot in the morning).
4. What was your favorite dish?
Definately the butternut squash and apple casserole
5. Were you on clean up crew or the one that just kicked back?
Umm, I was the clean up crew. Birds don't do dishes!
6. Who was the funniest one there?
Alex, the sun conure
7. Who was the drama queen?
Rudy, the quaker parakeet
8. Will the same people come over on Christmas that came on Thanksgiving?
Oh yes, they spend all of my holidays with me, even when I travel
9. Did you play music or watch the football games?
The new Christmas cd from Starbucks
10. Any drinking involed?
Just water and coffee
11. Anyone get out of hand and had to put them in their place?
Only Alex, when he decided that cauliflower belonged on the floor, rather than in his food dish
12. Who did you talk the most with?
13. Did you feel out of place at all?
14. Will you start decorating for Christmas on Black Friday?
Probably the following week, as I was wrapping Secret Santa gifts on that Friday
15. Did you go shopping on Black Friday?
Only at the very end of the day, after swinging past the post office
16. If so, What time did you get out of the house?
8 pm
17. Was anyone new at Thanksgiving dinner this year?
18. Did you miss anyone for thanksgiving/if so who?
My family
19. Whats the next thing you do right after thanksgiving?
Start training for the Boxing Day 10-Miler...it helps me work off the turkey and dressing.
20. Anything eles you would like to add about your Thanksgiving?
I'm thankful for having found this group on LJ!
What you do is tell them all the meds you take and it lets you know if there are any potential risks of mixing them. I was looking for something like this in the past, now I feel alot better knowing my meds are ok together :)
I know whining isn't going to make anything better, but have any of you NOT realized how much weight you've gained. *sighs* I was going through highschool pictures ( I was heavy then) but.... sighs.... yes, I suck. Granted this was 5 years ago....
I would GIVE to look like that again..... I'm SO discouraged. From a size 14-16 to now a 18-20-22? *sighs* I'm not looking for Pitty really..... I promise, I am just venting. Good Times.
Hey everyone!! Just checking in, I'm not dead!
Mom's wedding (and thanksgiving) is tomorrow and I am running around like MAD trying to get all this stuff prepared. I am currently making a 12inch 3 tier wedding cake, green beans, and macaroni and cheese, AHHHHHHHHHHH!
Hopefully all the food wont make me gain a bagillion pounds and I will be back to the YMCA on Monday, maybe even sooner if I can convince the hubby to hold the fort down...grrrr
Today I went to the gym for the first time this week and got in 40 minutes and 8.3 miles - not as much as I would have liked but for some reason my leg hurt so I let it go a little bit. I plan on starting the classes hopefully sometime this week, they look kind of fun! :-)
Top 10
1. The Long Walk - Stephen King
2. Carrie - Stephen King
3. The Green Mile - Stephen King
4. Watchers - Dean Koontz
5. The Magicians Nephew - C.S. Lewis
6. The Lion, The Witch and the Wardrobe - C.S. Lewis
7. Life Expectancy - Dean Koontz
8. The Shining - Stephen King
9. A Walk To Remember - Nicholas Sparks
10. Message In A Bottle - Nicholas Sparks
Weekly Theme:
Knowing you have support when you start your weight loss journey is important. Lets talk about where we find our support. Do you feel you get enough support from those around you? How did you go about finding the right type of support for you? How do you try to support others that are on the same journey as you are? Have there been times when someone tried to support you so much, that it felt like they were stepping over the line?
Sadly, I don't get anywhere near as much support as I should... my parents support me but them being in America doesn't really help when I'm 10,000 miles away. So I do my best with what I have... I've pretty much joined this community and up4thechallenge, I find both communities a bit of support. Makes me feel... I guess like I'm doing a good job, some online friends help too and of course my husband... but it's hard when we're both stressed from our child. I try to support people by giving them advice if they need it or just plain telling someone they did a good job is a good way of making people feel like you care. I mean, it really helps, even a few words make someone feel better - I know it does for me... anyways, being in these communities really makes a difference and reporting my miles it just makes me feel good that I was able to accomplish something that sometimes it doesn't feel like I can even get out of bed let alone anything else.
Oh, something that happened the other day (Friday) I was on the rowing machine and a personal trainer came up to me and told me that I was doing a great job, and that consistency is the key... that made me feel REALLY good! :-) It made me write down all the classes she runs so I can be in her classes - even though her classes look like fun I know I'll feel good about being in her class and not less than the people that are much more fit than me at the moment.
Top Ten Favorite Books
1. Bag of Bones by Stephen King
2. Once a Runner by John Parker
3. The Princess Bride by William Goldman
4. Heart Monitor Training for the Compleat Idiot by John Parker
5. Marathon Woman by Kathrine Switzer
6. A Race Like No Other by Liz Robbins
7. Harvest Home by Thomas Tryon
8. I'm Just Here for the Food by Alton Brown
9. Run Tall, Run Easy by Coach Gerard "GP" Pearlberg
10. Staying the Course: A Runner's Toughest Race by Dick Beardsley
Many of us have been on this journey for a while and we have had a backslide into that not so good place. What are the things that have happened in your life that shook the cob webs away and got you back on the wagon. Was is a comment someone made. Was it a piece of clothing you found. What made you shake the dust off your running shoes and get them back on your feet.
I hope everyone has a great week. For those the celebrate Thanksgiving this week, I wish you a friend and family filled holiday you will remember. For those that don't do Thanksgiving, celebrate yourself this week. Do something nice for you that you haven't done in a while.
Weekly community goal: I thought this week we could do an exercise challenge. The old record for exercise minutes was 1800 minutes. Let's try to break that with 2000 minutes.
Weekly theme: Knowing you have support when you start your weight loss journey is important. Lets talk about where we find our support. Do you feel you get enough support from those around you? How did you go about finding the right type of support for you? How do you try to support others that are on the same journey as you are? Have there been times when someone tried to support you so much, that it felt like they were stepping over the line?
Weekly top ten: Your top ten favorite books. Any genre is welcome one cook book or exercise book would be great.


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Orange-Flavored Oriental Pork
|Boneless pork shoulder
|1 Pound, cut into 1/4 inch strips (fresh)
|1⁄2 Cup (8 tbs)
|Orange juice
|1⁄2 Cup (8 tbs)
|1⁄4 Teaspoon
|1⁄8 Teaspoon
|Soy sauce
|3 Tablespoon
|Sliced water chestnuts
|1 Can (10 oz), drained
|Bean sprouts
|1 Can (10 oz), drained
|Thinly sliced chinese cabbage
|2 Cup (32 tbs)
|1 Tablespoon
|Cold water
|1 Tablespoon
|Chopped green onions
|2 Tablespoon
Mix pork, 1/2 cup water, the orange juice, salt, pepper and soy sauce in 2 quart microwavable casserole.
Cover and microwave on medium (50%) until pork is tender, 16 to 20 minutes, stirring every 3 minutes.
Stir in water chestnuts, bean sprouts and cabbage.
Cover and microwave on high until cabbage is crisp tender, 3 to 4 minutes.
Blend cornstarch and 1 tablespoon water in 4 cup microwavable glass measure.
Drain juices from meat mixture into cornstarch mixture; stir well.
Microwave uncovered on high until mixture boils and thickens, 3 to 4 minutes, stirring every minute.
Pour over meat and vegetables.
Sprinkle with onions.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1217 Calories from Fat 515
% Daily Value*
Total Fat 57 g88%
Saturated Fat 19.9 g99.7%
Trans Fat 0.5 g
Cholesterol 281.3 mg93.8%
Sodium 3478.1 mg144.9%
Total Carbohydrates 74 g24.7%
Dietary Fiber 10.8 g43.3%
Sugars 25.2 g
Protein 97 g193.1%
Vitamin A 156% Vitamin C 297.7%
Calcium 29.8% Iron 72.5%
*Based on a 2000 Calorie diet


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5.0 stars 12 reviews
Avvo Rating: 10
I get the best results possible for my clients, specializing in the areas of family law and bankruptcy. If you're facing a personal crisis, whether family or financial, you don't have to face it alone. Let me help you get the best results possib...
Practice areas & skills: Divorce & Separation, Family, Chapter 13 Bankruptcy, Chapter 7 Bankruptcy, Bankruptcy & Debt
5.0 stars 16 reviews
Avvo Rating: 10
Litigator, negotiator, mediator and trusted advisor, Erika Salerno views her relationship with every client as a partnership. She sees her role as one of empowering clients with the knowledge to make informed decisions, and when necessary, zealou...
Practice areas & skills: Child Custody, Divorce & Separation, Mediation, Family, Business
5.0 stars 11 reviews
Avvo Rating: 9.4
Review: "Attorney Aylward is an excellent choice. She is very professional and at the same time very personable and caring. She is very deligent in getting answers and relaying info back to the client. She is very fair with her...
Practice areas & skills: Appeals, Family, General Practice, Estate Planning, Real Estate
Not yet reviewed
Avvo Rating: 10
As a trial lawyer, I represent individuals injured as a result of nursing home neglect and abuse, as well as medical malpractice. Residents of nursing homes and long-term care facilities and their families should not have to worry about abus...
Practice areas & skills: Nursing Home Abuse and Neglect, Medical Malpractice
5.0 stars 4 reviews
Avvo Rating: 8.6
I attended Grand Valley State University undergarduate school. I attended University of Detroit-Mercy Law School. While attending law school I worked in the prosecutors' office in Washtenaw County, (Ann Arbor, MI). Most of my experience was i...
Practice areas & skills: Criminal Defense, DUI & DWI
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Avvo Rating: 9.2
I have been personally involved in the private practice of commercial civil law continuously in Battle Creek, Michigan since 1975. Martindale Hubbell, the only known confidential attorney peer review publication, has rated me as av and preeminent...
Practice areas & skills: Real Estate, Wills & Living Wills, Commercial
5.0 stars 12 reviews
Avvo Rating: 8.2
I attended Michigan State University from 1986-1990 and earned a bachelor of arts degree in accounting. I then went on to obtain my law degree in 1993 from Indiana University (ranked among the top 20 law schools in the country). After graduating...
Practice areas & skills: Elder Law, Estate Planning, Trusts, Probate
5.0 stars 5 reviews
Avvo Rating: 8.1
I have been with Steffel & Steffel, a small AV-rated law firm in Battle Creek, Michigan since 1995. Prior to returning to Michigan, I worked at two law firms in the Northern Virginia area.My "marketing plan" always has been to provide the best pos...
Practice areas & skills: Business, Social Security, Estate Planning, Real Estate, Probate
5.0 stars 1 review
Avvo Rating: 8.1
I devote a majority of my practice to representing individuals injured as a result of nursing home neglect and abuse and medical malpractice.When placing the care of a loved one into the hands of another, family members want to feel secure knowing...
Practice areas & skills: Nursing Home Abuse and Neglect, Medical Malpractice
5.0 stars 11 reviews
Avvo Rating: 7.9
Review: "Mr. Bomia has handled several business matters for me as well as for my clients. I was impressed with his professionalism when dealing with myself and the others. He presented legal choices to me and also listened to my ...
Practice areas & skills: General Practice, Real Estate, Estate Planning, Lawsuits & Disputes, Bankruptcy & Debt
|Bankruptcy and debt
|Child support
|Estate planning
|Medical malpractice
|Real estate
|Workers compensation
|Brain injury
|Criminal defense
|Mesothelioma and asbestos
|Social security
|Wrongful termination
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|Speeding and traffic ticket
|Car accident
|Divorce and separation
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|Trucking accident


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Welcome to 1289 N Ellington Pkwy, home to Domino's and the best pizza delivery in Tennessee! We're the restaurant to beat, offering you millions of ways to create your pizza and delivering them right to your door! The Domino's menu caters to all tastes, whether you're a fan of vegetables or pepperoni.
And we go beyond pizza. When it comes to wings, for example, Domino's takes chicken to new heights of deliciousness. We always serve wings that are fresh out of our ovens, baked-to-order.
What's on the menu? You could stick with a classic: our oven-baked bone-in wings. When our morsels of goodness come out of the oven, we cover them with your choice of sublime sauces in all kinds of flavors. Or mix it up with boneless wings, with light breading and bevvy of spices to complete the perfect bite. Want even more flavor? Pick from our dipping sauces for a customized kick. Order any of our saucy treats, from subtly sweet (that's the Mango Habanero Sauce) to spicy (our classic Buffalo Wings Kicker Hot Sauce) to creamy and cool (reach for Ranch dressing). Every order promises deliciousness. Yep, wing delivery from Domino's is all about serving the best. We also offer entrées like pasta dishes and hot oven-baked sandwiches, as well as sides like salads, drinks, and our stuffed cheesy breads. And don't forget about dessert! Why do we offer so many choices? It's simple: we aim to bring you the best.
To further enhance your Domino's experience, we make it simple to order from your local store any way you want! You can call us, order from our website, or download the Domino's app to your smartphone and place an order on the go. Because we operate over 11,700 locations in more than 75 countries, we know what it means to be the best. With the ability to order online, a smartphone ordering app, and over 34 million different ways to create your pizza, it's all about you here at Domino's.
Mon-Thu: 10:30 a.m. to 11 p.m.
Fri-Sat: 10:30 a.m. to 12 a.m.
Sun: 10:30 a.m. to 11 p.m.
(931) 359-7000


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The purpose of the proposed program is to train the next generation of scholars in developmental psychopathology who will conduct research addressing the first three of NIMH's strategic objectives from a developmental perspective. The proposal requests continuation of a training program at the Institute of Child Development, University of Minnesota continuously supported by the National Institute of Mental Health since 1959. The award-winning faculty on the training grant reflect various sub-disciplines of developmental science, including child clinical psychology, developmental behavioral neuroscience/developmental psychobiology, socioemotional development, cognitive development, pediatrics, and prevention/intervention science. The proposal seeks support for 4 predoctoral and 2 postdoctoral trainees for 2-year terms. In any given year, the predoctoral trainees represent approximately 10% of all Ph.D. students in the Institute of Child Development;thus being placed on the training grant is highly competitive. Students enter the training grant as 3rd or 4th year Ph.D. students so that we can be more confident of their talent and of their commitment to research areas pertinent to NIMH's strategic goals. Postdoctoral trainees are selected based on evidence of research potential, strong recommendations, and fit with the program. Predoctoral trainees complete one of two Ph.D. tracks, the Developmental Science track or the Developmental Psychopathology Clinical Science track;the latter involves a one-year clinical internship. All predoctoral trainees receive training in developmental psychopathology, grant writing, professional development, ethics in research, statistics, and cognitive and social development as part of the larger Ph.D. program. Coursework is mostly completed by the end of the 2nd year, and thus those students on the training grant (3rd-5th year students) can devote most of their time to research. Postdoctoral students complete the grant writing course and, in consultation with their faculty mentor and the training grant director any areas of developmental science that are critical to their research program and in which they lacked sufficient prior training.
This proposal seeks funds to continue a training program begun in 1959. Its goal is to train the next generation of scholars who will 1) enhance our understanding of how experience gets under the skin and operates in relation to genetic endowment to promote healthy and maladaptive psychological functioning and 2) design, implement and test better treatments and preventive interventions to support the healthy psychological development of all of our nation's children.
|Shlafer, Rebecca J; Raby, K Lee; Lawler, Jamie M et al. (2015) Longitudinal associations between adult attachment states of mind and parenting quality. Attach Hum Dev 17:83-95
|Narayan, Angela; Cicchetti, Dante; Rogosch, Fred A et al. (2015) Interrelations of maternal expressed emotion, maltreatment, and separation/divorce and links to family conflict and children's externalizing behavior. J Abnorm Child Psychol 43:217-28
|Doom, Jenalee R; Georgieff, Michael K; Gunnar, Megan R (2015) Institutional care and iron deficiency increase ADHD symptomology and lower IQ 2.5-5 years post-adoption. Dev Sci 18:484-94
|Raby, K Lee; Roisman, Glenn I; Fraley, R Chris et al. (2015) The enduring predictive significance of early maternal sensitivity: social and academic competence through age 32 years. Child Dev 86:695-708
|Narayan, Angela J; Sapienza, Julianna K; Monn, Amy R et al. (2015) Risk, Vulnerability, and Protective Processes of Parental Expressed Emotion for Children's Peer Relationships in Contexts of Parental Violence. J Clin Child Adolesc Psychol 44:676-88
|Afari, Niloofar; Ahumada, Sandra M; Wright, Lisa Johnson et al. (2014) Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosom Med 76:2-11
|Doom, Jenalee R; Georgieff, Michael K (2014) Striking while the iron is hot: Understanding the biological and neurodevelopmental effects of iron deficiency to optimize intervention in early childhood. Curr Pediatr Rep 2:291-298
|Koss, Kalsea J; Hostinar, Camelia E; Donzella, Bonny et al. (2014) Social deprivation and the HPA axis in early development. Psychoneuroendocrinology 50:1-13
|Cutuli, J J; Herbers, Janette E; Lafavor, Theresa L et al. (2014) Asthma and adaptive functioning among homeless kindergarten-aged children in emergency housing. J Health Care Poor Underserved 25:717-30
|Doom, Jenalee R; Gunnar, Megan R; Georgieff, Michael K et al. (2014) Beyond stimulus deprivation: iron deficiency and cognitive deficits in postinstitutionalized children. Child Dev 85:1805-12
Showing the most recent 10 out of 39 publications


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Top Definition
A vomit-worthy radio station in NYC that makes all the trendies jump for joy. This includes 'hotties' , 'jocks' and 'glam-hoes'. They have even been mislead enough to think that KTU plays underground music. Very sad indeed. Also another way of saying a certain music is bad.
"Ew! omfg! this shit is so KTU!! *throws it in the trash*"
"LOL @ that KTU garbage! All the trendies have the nerve to jump to this bullshit!?"
"LOL @ that KTU garbage! All the trendies have the nerve to jump to this bullshit!?"
by some guy June 07, 2003
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug
The Urban Dictionary T-Shirt
Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).Buy the t-shirt


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A glossy magazine using plus-size models goes on sale worldwide today - at a time when the fashion industry seems to be embracing diversity.
SLiNK, the UK's first plus-size fashion magazine distributed across 15 countries, is hoping to tap into a growing demand for publications that, in the words of editor Rivkie Baum, realise "beauty and style doesn't stop at a size 8".
"We believe that women are tired of seeing the same unobtainable image. Women today are much more savvy," Baum says.
"As the plus-size retail sector continues to outgrow its straight size counterpart, the market is crying out for an inspirational plus-sized publication."
Each edition will include shopping features, interviews, features, travel and beauty tips in efforts to "change the reputation of plus size fashion".
Baum also addressed the questionable argument that a plus-sized magazine would promote unhealthy bodies as much as regular fashion publications.
"We are extremely conscious of our responsibility to promote a healthy body image both physically and mentally," Baum told The Independent. "In our next issue, we are introducing a new healthy eating and fitness column to further back this. But what we are also aware of is that health doesn't come in one dress size and there are numerous factors that play a part in our wellbeing.
"While many magazines promote crash diets, which are extremely unhealthy, we believe that empowering women to feel confident and good about themselves at whatever size they are can have knock on effects on their overall health and lifestyle choices. It's about promoting health and happiness without suggesting it can only be achieved at one dress size."
Also, unlike regular glossies, Slink has a "strong policy on body alteration". Baum said: "We never photoshop bodies smaller at all, we will do lighting corrections, light balance that kind of thing."
The "aspirational" publication started as an online only publication back in 2011, printing its first edition in 2012, which was only retailed via its website. It wasn't until now that the bi-monthly publication hit the UK shelves, after proving that its plus-size editorials could "sit comfortably alongside their straight sized counterparts".
The launch of Slink in the UK (and in other 14 countries) shelves joins American publications such as Plus Model, and the wave of plus size trends in social media and fashion industry. Model Candice Huffine, whose size UK 16, has been featured in numerous fashion campaigns and publications such as Vogue Italia and V Magazine. Also, she has just been unveiled as the first official plus-size model of Pirelli Calendar. But she told The Independent: "The idea of my size or weight has never come up in the casting process or even the thought process."
Mrs Baum added: "I think it's really exciting that models such as Candice Huffine are managing to break down barriers. We have always aimed to show that plus size models aren't second class, they can perform in editorial just as well as their straight size counterparts and inclusions in big campaigns demonstrates that others are recognising the talent these girls have and that a one size fits all approach is quickly becoming out dated.
"Candice looks just as incredible as the other girls in the Pirelli Calendar [2015] and this is because she is fantastic at what she does."
This trend has picked up in the last five years. In 2010, designer Mark Fast used plus-size models in his London catwalk show, while Jean Paul Gaultier enlisted size UK 20 gossip singer Beth Ditto to walk in his spring/summer 2011 show.
In 2012, Vogue pledged to only use models over the age of 16 and with a healthy body weight.
Also, back in summer this year the hashtag #fatkini spread across social media with plus-size women sharing pictures of themselves in bikinis, which was triggered by beauty and fashion plus-size blogger Gabi Fresh. She told The Independent: "I truly encourage you guys to get to the beach (or a pool) this summer – don't let body shame keep you from having a good time."
The average dress size of a woman in the UK is 16, but more than health and self-image, the industry is seemingly beginning to understand that plus-size women too have "spending power, both in fashion and beauty". Retailers such as Marks and Spencer, Dorothy Perkins, Forever 21 and Asos all have wide-ranging, plus-size clothing lines.
The idea that women come in all shapes and sizes is slowly becoming a truth universally known.Reuse content


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|Oklahoma Golden Retriever Rescue
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|Rescue Me ID: 16-05-31-00327Rosco (male)
Rosco is a very gentle loving dog. Tender kisses. Gentle when being fed treats. Loves to snuggle and be close. Not very vocal. House and kennel trained. Loves to dig. We have had to lay concrete around our fence to keep him from digging under and going to other yards. He does well with men. He growls around females and some kids. Has never bitten anyone but seems somewhat dominant with females and kids. He loves to go on walks. Absolutely loves to play fetch!
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|PIease Read Before Adopting a Golden Retriever in Oklahoma
Golden Retriever Dogs can make good pets in Oklahoma if they match your IifestyIe. The Golden Retriever is a gundog that loves the water. Originally bred for hunting, Goldens make wonderful family pets. Golden Retrievers are very sweet, patient, gentle, and excellent with children. Goldens are eager to please and respond very well to obedience training. Goldens make good watchdogs but are far too friendly with everyone, from strangers to other dogs, to be used as guard dogs. Goldens need human companionship. They can get into trouble if neglected. This breed is suitable for homes with yards, and needs plenty of brisk daily exercise.
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If you have experienced the loss of a beloved pet, or if you know someone who has... [POST A MEMORIAL HERE]
|Help Spread the Word! Please link to Oklahoma Golden Retriever Rescue from your website.
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Ekavi Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Ekavi Hotel Rethymnon
Travel Blogs from Rethymnon
Xania or Chania.
... We, the other three, decide we should drive to a "nearby" beach. It's about 5 klms away so off we go. Before you know it I'm confidently driving down a one way. The wrong way. Minor problem. We're on our way. Paul has the map in the back. Lisa is asking if he can see such and such street. Paul says "Do you see anything that starts with a K". The street signs are in Latin and Ćirilic when they're there. We get lost and found and lost again. Leaving ...
Day 11 Explorer of the Seas
... and delightful maze of alleys and side streets. The area is a mix of Byzantine, Greek, Venetian and Turkish architecture. Tomorrow is a sea day. So we are just going to be lazy. The only thing we have to do tomorrow is meet face to face with Israeli immigration officials. We have an appointment with them in the morning. Those officials came on board in Barcelona. The following day we will be in Israel. It will be Happy Hour ...
Cruisin' for a Bruisin': Part I
... an ancient, but still active, massive volcano that blew millions of years ago leaving this u-shaped island of wonder. The island is tall, very steep, full of dark stratigraphic rock layers (Blake was in geoscience heaven), with the all-white towns way up at the top. From far away, it almost looks like snow caps covering mountain peaks. The island is considered a 'caldera' which is a volcano that has had a major eruption, collapsing the mouth of the volcano. In the center of ...
A generous Brit.
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A secluded beach day
I wake up to the sound of my phone buzzing on the table next to me, and see that John is calling over FaceTime. Immediately, we know what it's going to be about, but Aaron takes the call and we receive the news that A.C. passed peacefully overnight. Aaron comes back into the bedroom and we have a huge cuddle on the bed before I start brewing some coffee. This morning we are planning to go to a much nicer beach, however they're really far away, we're talking like 2hours ...
Other places to stay in Rethymnon
Aquila Porto RethymnoVenizelou 52A, Rethymnon | 4 star hotelfrom $178
- Not quite perfect
- Bravo!!
- Friendly staff
Theartemis Palace Hotel26 Portaliou Emmanouil, Rethymnon | 4 star hotelfrom $119
- Fabulous Hotel Great Holiday
- Great hotel
- Loved Theartemis, Rethymnon
Grecotel Creta Palace HotelMissiria, Rethymnon | 5 star hotelfrom $253
SENTIDO Pearl BeachBeach Road, Rethymnon | 4 star hotelfrom $98
Bio Suites Hotel13 Svaitser, Rethymnon | 4 star hotelfrom $117
Ideon Hotel10 Square North Plastira, Rethymnon | 1 star hotelfrom $88
- Great hotel, great site, great resort
- Great Hotel, Fantastic Location, Friendly Staff
- Well worth the stay
Olympic Palladium42 Themistokli Moatsou Str, Rethymnon | 3 star hotelfrom $73
Minos Hotel5 Machiton Scholis Chorofilakis, Rethymnon | 4 star hotelfrom $76
Brascos Hotel1 Daskalaki, Rethymnon | 3 star hotelfrom $50
Jo-An Palace Hotel8 Dimitrakaki S., Rethymnon | 4 star hotelfrom $79
Litsa's Lefkoniko Beach Hotel3 Likourgou Kaffatou, Rethymnon | 3 star hotelfrom $45
Atrium Ambiance Hotel24 Markou Portaliou, Rethymnon | 3 star hotelfrom $82
Grecotel Plaza Spa Apartments60 Ari Velouchioti, Rethymnon | 4 star hotelfrom $183
Fortezza HotelUntertürkheim, Rethymnon | 3 star hotelfrom $113
Lefkoniko Bay2 Panepistimiou, Rethymnon | 3 star hotelfrom $49
Steris Elegant Beach Hotel Apartment1 Konstadinoupoleos, Rethymnon | 3 star hotelfrom $71
Astali Hotel1 Papandreou Georgiou, Rethymnon | 2 star hotelfrom $70
Achillion Palace27 K Giamboudaki Str, Rethymnon | 4 star hotelfrom $66
Cosmos Hotel2 Alb. Schweitzer, Rethymnon | 3 star hotelfrom $60
Olympic II52 Velouchioti Ari, Rethymnon | 4 star hotelfrom $66
Kriti Beach HotelPapanastasiou Street, Rethymnon | 4 star hotelfrom $152
Marino's Beach Hotel ApartmentsMaxis Kritis 196, Rethymnon | 4 star hotelfrom $53
Jo-An Beach HotelAdelianos Kampos, Rethymnon | 3 star hotelfrom $65
Kyma Beach HotelAgnoston Stratioti Sq, Rethymnon | 4 star hotelfrom $133


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North America
CDM Smith wins 2016 IBTTA Toll Excellence Award for National Interstate Tolling Analysis Tool.
file under:
Federal Government, Government, Transportation, United States
CDM Smith has acquired The Louis Perry Group (LPG), a multi-disciplined engineering, architectural and design-build firm that specializes in process, civil, structural, electrical, mechanical, instrumentation and controls engineering to service power, industrial, rubber, plastics, chemical and commercial clients. LPG, based in Wadsworth, Ohio, has been serving clients since 1985.
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Industrial, Chemicals, Food and Beverage, Metals and Mining, North America, Oil and Gas, Power, United States
CDM Smith has been awarded a $9.8 million design-build project by the General Services Administration Denver Special Projects Division to upgrade infrastructure at the U.S. Customs and Border Protection Piegan Land Port of Entry and Border Patrol Station located near Piegan, Montana.
file under:
Design-Build, Federal Government, North America, United States, Water
Join CDM Smith experts as we explore recent trends in advanced treatment of process wastes from food and beverage production focusing on brewery wastes. We'll dive into the current methods of anaerobic and aerobic treatment and present potential advancements in membrane technologies. We'll help you understand how you can reduce costly surcharges, achieve a higher quality effluent for potential reuse, and increase your biogas production.
file under:
Industrial, Water Reuse, United States, Sustainability, North America, Membranes, Energy
Out of 212 applicants for the FAST Act-authorized grant program, 18 grants were awarded, totaling nearly $760 million to fund freight transportation projects throughout the United States. CDM Smith supported winning applications by both the Oklahoma DOT and Louisiana DOTD.
CDM Smith was recently honored with the CASFM 2016 Grand Award for the South Platte River Vision Implementation Program, a stream restoration and recreation improvement program that provides habitat, flood control, and community resources for the Denver area.
file under:
United States, Water, Green Design, Environment
CDM Smith will participate at the Association of State Floodplain Managers 2015 Conference in Altanta, Georgia, with several technical presentations and moderated sessions. The ASFPM annual conference is recognized as the most important floodplain conference in the United States.
file under:
Emergency Response, Federal Government, Government, North America, Sustainability, Water, United States
Smith participated with presentations and moderation sessions at the Association of State Floodplain Managers 2016 Conference, held June 19-24 in downtown Grand Rapids, Michigan, USA.
Clean Harbors and CDM Smith are building the United States' first new thermal treatment plant in more than 20 years, enabling Clean Harbors to meet growing customer needs and address the demand for destruction of extremely high-hazard waste streams.
file under:
Design-Build, Chemicals, Facilities, Industrial, Oil and Gas, United States
J.R. Simplot Company's process water treatment and return plant in Caldwell, Idaho, was named WateReuse's 2016 Industrial Project of the Year. This innovative facility raises the bar for water reuse in food industries by reclaiming 1.7 million gallons per day, equivalent to drinking water standards, for safe reuse in potato product manufacturing.
file under:
Design-Build, Food and Beverage, Industrial, Sustainability, United States, Water, Water Reuse
Jillian C. Vandegrift has been named Young Professional of the Year by WateReuse.
file under:
Sustainability, Water, United States, Environment, Water Reuse
Stanley Boc, a geologist and geoscientist with 40 years of coastal restoration experience, has joined CDM Smith.
file under:
Sustainability, Water, Emergency Response, United States, Green Design, Environment
Enhanced anaerobic bioremediation, which leverages naturally occurring bacteria, boosted by simple lactate, is the sustainable, effective remedy that Rockwell Automation was looking for to clean contaminated groundwater in Florida.
file under:
Environment, North America, United States, Bioremediation, Industrial
CDM Smith's patented gaseous electron donor injection technology is an innovative, versatile and environmentally friendly in situ approach to remediate perchlorate and nitrate contamination, protecting groundwater; minimizing expensive drinking water treatment technologies; and treating many other contaminants.
file under:
Bioremediation, Industrial, Chemicals, Environment, Federal Government, North America, Oil and Gas, United States
In Sarasota, Florida, the race to enhance North Cattlemen Road and a nearby regatta course took coordination. We led the effort to align the projects' timelines and the stakeholders' needs. At the finish line, the county won hosting duties for the 2017 World Rowing Championships.
file under:
Government, Transportation, United States
CDM Smith partnered with the Florida Department of Transportation to produce the state's Freight Mobility and Trade Plan, a focused policy and investment strategy to increase and enhance multimodal trade worldwide.
We partnered with the Minnesota Department of Transportation to design, develop, implement and operate the MnPASS express lane system, which uses an innovative new tolling design to offer additional capacity of existing high occupancy vehicle lanes to single occupant vehicles.
Los Angeles World Airports launched an industry trend-setting initiative to build sustainable practices into its business model. This ambitious program will further enhance the airport's role as a key driver in national and regional economic growth, social responsibility and environmental stewardship.
file under:
Government, Sustainability, Transportation, United States
Since it was built in the 1960s, Seattle's old SR 520 floating bridge had become vulnerable to windstorms and earthquakes and had limited capacity and no access for pedestrians and bicyclists. Seeking a funding source for the construction of a new floating bridge over Lake Washington, WSDOT turned to tolling.
file under:
Transportation, United States
The State Highway 183 Managed Lanes project is one of the largest and most complex projects in Texas transportation history. Unsurprisingly, procuring private-sector participation on the project required several unique financing and delivery approaches. Starting in 2013, CDM Smith partnered with TxDOT to manage the procurement's successful completion.


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Lindows Seeks To Leverage 1992 Apple Court Loss In Windows Trademark Battle
Lindows Seeks To Leverage 1992 Apple Court Loss In Windows Trademark Battle
by , 10:00 AM EST, March 3rd, 2003
What comes around, goes around, or so Lindows.com. The feisty Linux company has issued a press release announcing developments in its ongoing court battle with Microsoft over the Windows trademark owned by Microsoft. Lindows recently gained the attention of the Mac community when the company released a US$799 LindowsOS laptop, and compared it to Apple's 12" PowerBook. Extra attention came from the fact that the company mislabeled the PowerBook as the "iNote," and got several other details wrong, though the company quickly corrected the mistake. (See also our System Shootout between Apple's iBook and the Lindows MobilePC).
Today's announcement from the company involves a trademark battle with Microsoft. What began as an attempt by Microsoft to keep Lindows from using its name on the basis of its resemblance to Windows has turned into a situation where the Windows trademark could well be taken away from Big Redmond.
Lindows is seeking to use court statements from Apple's failed 1992 attempt to keep Microsoft from using elements of the Mac OS in the then-fledgling Windows OS. Apple lost that case, in part because of licensing agreements between the two companies that effectively gave Microsoft permission to use those elements, and in part because Microsoft successfully argued that things like windows, icons, and the like existed before the original Mac OS. According to today's announcement, Lindows apparently hopes to use Microsoft's own words from that court case against the company. From that press release:
The United States District Court in Seattle has ordered Microsoft to produce more than 300 boxes of evidence in the "windows" trademark dispute, resulting in a trial delay. The jury trial was scheduled to begin on April 7, 2003, and has now been rescheduled to begin on December 1, 2003.
The newly produced documents include documentation from the 1992 Apple vs. Microsoft case. The documents reveal that elements such as windows, icons and menus were not the property of any one company because they were widely used in the computer business. This is contrary to Microsoft's current argument that they should maintain exclusive use of the word "windows". In last year's March 15, 2002, Order denying Microsoft request for a preliminary injunction against Lindows.com, the Court noted that, "In its defense of a copyright suit brought by Apple Computer, Microsoft successfully argued that several companies had introduced user interfaces featuring overlapping windows prior to Microsoft's announcement of its Windows product."
"We're grateful for the additional time to examine the hundreds of thousands of pages that Microsoft has previously refused to produce, but now is required to produce by the Judge," said Michael Robertson, chief executive officer of Lindows.com, Inc. "We're hopeful the documents will add to the mountain of evidence that demonstrates the term 'windows' is generic and not the exclusive property of any one company."
"We expect those boxes to include testimony from dozens of witnesses, court transcripts, and demonstrative evidence Microsoft introduced to demonstrate the development of windowing systems in the 1970s and early 1980s, before both Apple and Microsoft developed their own," stated Daniel Harris, lead counsel for Lindows.com. "We also expect to receive more documents which will shed light on how Microsoft was able to obtain a trademark for 'windows' after the United States Patent and Trademark Office repeatedly refused registration because the mark was deemed to be generic."
You can get more information about Lindows.com at the company's Web site.
The Mac Observer Spin:We wish the company well in this endeavor. We aren't taking an opportunity to pile on Microsoft; it is instead a matter of principal. Microsoft being able to trademark "Windows" would be similar to Logitech or Kensington getting a trade mark on "Mouse." Lindows rightfully argues this mark should never have been issued in the first place. Attempting to keep Lindows from using that name is clearly abuse of the trademark, and is exactly why Microsoft shouldn't be allowed to keep it.
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Neuronal nicotinic cholinergic receptors are expressed throughout the brain, in the spinal cord, and in the autonomic ganglia. Eleven neuronal nAChR subunit genes were cloned and sequenced in the 1980's. Some of these subunits closely resemble the a1 subunit that is included in the nAChR that is expressed at the neuromuscular junction (the so-called peripheral-type receptor). These a1-like subunits are called: a2, a3...a10 and, with the exception of a5, provide the binding site for nicotine and other nicotinic agonists. The three remaining subunits, ?2-?4, are referred to as structural subunits. Enormous progress has been made towards understanding the structure and function of neuronal nAChRs using expression systems (cell lines, Xenopus laevis oocytes). For example, expression system studies have shown that subunit composition has profound effects on biophysical and pharmacological properties. The value of expression system studies has been limited, somewhat, because some of the more interesting subunits (e.g. a6, ?3) are not easily expressed in artificial systems. These, and other concerns, have prompted researchers to develop gene knockout (null mutant) mice for virtually every one of the known nAChR subunits. Transgenic mice have also been developed that express several gain of function mutations, or mutations that are associated with human diseases. These transgenic mice are being used to address questions such as: 1) What are the subunit compositions of naturally-occurring (i.e. native) nAChRs? 2) Where are these native receptors expressed? 3) What role do they play in modulating brain function (behavior?), and 4) What function do these receptors play in modulating addiction to nicotine, alcohol and other drugs? We have the world's most complete collection of nAChR mutant mice that are being used in several funded research projects that are centered at the University of Colorado. During the last 4 years we have built our colony from five mutant strains to 18 and have established a system where we have sent mice and/or breeding pairs to other researchers in the US and, more recently around the world (3 continents, to date). This application requests funds to support the continued maintenance and distribution of these mouse stocks.
|Stoker, Astrid K; Marks, Michael J; Markou, Athina (2015) Null mutation of the ?2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice. Eur J Pharmacol 753:146-50
|Wilking, Jennifer A; Stitzel, Jerry A (2015) Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds. Neuropharmacology 96:205-12
|Bates, R C; Stith, B J; Stevens, K E et al. (2014) Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits. Neuroscience 273:52-64
|McClure-Begley, Tristan D; Grady, Sharon R; Marks, Michael J et al. (2014) Presynaptic GABAB autoreceptor regulation of nicotinic acetylcholine receptor mediated [(3)H]-GABA release from mouse synaptosomes. Biochem Pharmacol 91:87-96
|Wageman, Charles R; Marks, Michael J; Grady, Sharon R (2014) Effectiveness of nicotinic agonists as desensitizers at presynaptic *4*2- and *4*5*2-nicotinic acetylcholine receptors. Nicotine Tob Res 16:297-305
|Koranda, Jessica L; Cone, Jackson J; McGehee, Daniel S et al. (2014) Nicotinic receptors regulate the dynamic range of dopamine release in vivo. J Neurophysiol 111:103-11
|O'Neill, Heidi C; Laverty, Duncan C; Patzlaff, Natalie E et al. (2013) Mice expressing the ADNFLE valine 287 leucine mutation of the ýý2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function. Pharmacol Biochem Behav 103:603-21
|Quik, Maryka; Campos, Carla; Grady, Sharon R (2013) Multiple CNS nicotinic receptors mediate L-dopa-induced dyskinesias: studies with parkinsonian nicotinic receptor knockout mice. Biochem Pharmacol 86:1153-62
|Marks, Michael J (2013) Genetic matters: thirty years of progress using mouse models in nicotinic research. Biochem Pharmacol 86:1105-13
|Soll, Lindsey G; Grady, Sharon R; Salminen, Outi et al. (2013) A role for *4(non-*6)* nicotinic acetylcholine receptors in motor behavior. Neuropharmacology 73:19-30
Showing the most recent 10 out of 62 publications


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Billy Reed's Restaurant Bakery & Bar > Billy Reed's Restaurant Bakery & Bar MenuAmerican | Palm Springs Main Menu
with chicken or beef
nachos supreme with spanish sauce and guacamole
grilled filet of salmon and southwest crunchy veggies,in a tortilla shell
with curry chicken salad or tuna salad,vegetable garnish
with cashew chicken salad or tuna salad, fresh fruit garnish
plump shrimp on a bed of greens,paantry garnish
hong kong classic
billys ceaser dressing recipe
with grilled chicken breast shrimp,or salmon
princess dressing
turkey, ham, shrimp & cheese,pantry garnish
our version of the brown derby classic
try our famouse homemade chili. "hot" chili with sirloin cubes. cup, bowl. straight chili 3 extra
cod, served with cole slaw potato chips and fries
fresh baked in our kitchen daily with side of fresh fruit or cole slaw
seafood 4 extra - served with garlic toast and salad
grilled chuck steak, chicken breast or filet of cod,served with fresh vegetables or fruit & cottage cheese choice of bread
assorted fresh vegetables,with cheese and choice of baked potato,sweet potato,or rice pilaf,dinner bread,soup or salid
homemade crab cakes served with homemade chips and coleslaw
enjoy our delicious caesar salad with a jumbo baked potato served with your choice of any two toppings - chili, cheese, fresh vegetables, mushrooms, bacon, chicken, beef, ham, spanish,hollandaise or marinara sauce.
generous cut of black angus beef served with creamy horseradish sauce.
our most tender steak served with sauteed mushrooms and wrapped with bacon.
a 'hefty' portion of ground sirloin mixed with green peppers & onions, spices, herbs, bread crumbs & eggs. topped with our special tomato sauce or, if you like it old fashioned. topped with natural gravy, served with macaroni and cheese or potato.
our version of chicken fried steak (with country gravy)
tender roast tips of beef, brown sauce au natural with mushrooms
grilled with onions and bacon. topped with mushroom gravy.
rasher of bacon, grilled onions, scallion hllandaise sauce.
top sirloin and golden brown shrimp. filet mignon and golden shrimp.
sauteed chicken breast with mushrooms, capers and lemon sauce
house favorite, chicken breast with almonds
sauteed breast of chickin cutlet with a coverlet of cheese,marinara sauce
jumbo-half tender chicken, fried to perfection (2 big punds)
sage corn bread dressing, mashed potatoes and giblet gravy, cranberries
tender and golden,fresh lemon,cocktail sauce
deep fried and golden,tropical sweet,chili dipping sauce
(fresh) grilled,with lemon/dill sauce on the side
lightly breaded, sauteed, fresh lemon and tarter sauce
freshest available,respective garnish
soup or salad
to take out
to take out
Disclaimer: Always check with the business for pricing and availability of menu items. SinglePlatform is not responsible for menu or pricing changes, but the information is believed to be accurate when posted. Listing of a menu does not mean that there is any affiliation, endorsement or sponsorship between SinglePlatform and the listed business.


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Unit Bid Analysis & Standard Item Table
Advance Schedule of Projects
Last Updated 6/30/16: PDF | Excel
For all project bid openings in Olympia and Wenatchee, WA.
For information on bid results and contract awards, please contact Jennifer Harper at (360) 705-7841.
NOTE: Contracts are awarded to the low bidder when awarded unless otherwise noted.
The following bid history reports reflect the advertised date, bid opening date, award date, bidders name and the bid total for each bidder on the contract opened within the indicated time period. An alpha character in front of a bidder's name in the reject code column indicates that bidder's bid was rejected.


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New Member
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post #1 of 3 Old 10-08-2012, 01:51 PM Thread Starter
What is this fish,
I have spent forever trying to find out, going through the fish profiles on here and haven't found it yet, and trying to keep track of the last one I clicked on here. So Maybe one of you will know.
I have a 60 gallon freshwater (community) Tank since early 2011
post #2 of 3 Old 10-08-2012, 02:41 PM
|The Following User Says Thank You to Tigris For This Useful Post:
mt4no1 (10-08-2012)
post #3 of 3 Old 10-08-2012, 05:45 PM
Agree. It is in our profiles under the common name Denisons Barb, scientific name is Puntius denisonii. The profile sets out the specific requirements.
Byron Hosking, BMus, MA
Vancouver, BC, Canada
The aquarist is one who must learn the ways of the biologist, the chemist, and the veterinarian. [unknown source]
Something we all need to remember: The fish you've acquired was quite happy not being owned by you, minding its own business. If youre going to take it under your wing then youre responsible for it. Every aspect of its life is under your control, from water quality and temperature to swimming space. [Nathan Hill in PFK]
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Just in time for the holidays, get a FREE hardcover photo book from MyPublisher! Simply head over to their page, enter your email address and they will email you a code for your FREE book. The code will get you a FREE 7.75″ x 5.75″ hardcover pocketbook or $20 off any hardcover photo book. This offer is valid for new customers only.
:: Get more photo deals HERE.


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Louis Vuitton has come up with a version of the elegant Keepal duffel bag that you can drop in the ocean. This Keepall, created for the 2007 America's Cup, is identical to the original but is made from waterproof materials that are fused together by high-frequency welding. Again another product for those who wish to be one step ahead of the pack.
Implications - The bag is only completely waterproof when it is fully closed. You can fully submerge it into the water and it will be perfectly fine! The Louis Vuitton bag is a rich dark brown with the LV logo embossed all over and is a good size for people who are traveling.
Waterproof Designer Bags
More Stats +/-
Top 30 Robots Trends in February
Sesame-Based Alternative Condiments
Folding Origami Canoes
Charitable Cancer-Fighting Screwdrivers
Re-Released Retro Cell Phones
The Louis Vuitton Waterproof Keepall can be Thrown in the Ocean
Jul 8, 2007 Updated: May 12 2011By: Tao -
References: louisvuitton
References: louisvuitton


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Spotlight Article:
Selling Comfort and Providing Energy Efficiency
On a mission to help people make homes more energy efficient? So are we. Indow sells and installs interior window inserts in homes that help homeowners stay warmer in the winter and cooler in ...
Keep Reading
PRISM Does Windows
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A new and improved version of the most widely used computer software for analyzing retrofit energy savings from utility billing data is now available. [continue reading]
Beauty and the Beast Upstairs
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The same features that are often added to the top story of homes to give them distinctive architectural beauty can also make them rather beastly to heat or retrofit. [continue reading]
Ventilating Attics to Minimize Icings at Eaves
archive CONTENT
Icicles and ice dams form at the eaves of some roofs in cold regions. Water that ponds behind ice dams may leak into the building since most steep roofs are configured to shed water, not hold back standing water. [continue reading]
Don't Throw that Window Out the Window!
archive CONTENT
There are many ways to retrofit a window. Most strategies involve replacing the glass, frame, and sash with double-paned low-E glass, and a new wood or vinyl frame and sash. [continue reading]
"Superwindow" Retrofits Show Significant Energy Savings
archive CONTENT
Windows account for a fairly large percentage of the heat loss of houses. Even in new homes built to stringent energy code, windows still account for about 25% of the overall conductive heat loss. [continue reading]
Studs of Steel
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Rising lumber prices and an erratic market have driven some homebuilders to look for alternatives to wood framing, and steel framing is one option that is grabbing their attention. [continue reading]
Deborah E. Miller
Energy Efficient Appliances Save Consumers Cash
In the home performance industry, we are doing the Lord's work by ensuring that the homes Americans live ...
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How to Hook Every Type of Homeowner
When homeowners have an HVACR need, 80 to 90 percent begin their search for a provider on the Internet. Braving the wilds ...


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Safe Online Payments
|Bus Operator
|Last Bus
|Shrinath Travel Agency ISO 9001 Certified
|Shreenath travelers
|Laxmi Traveller
Ankleshwar to Jaipur Bus Service
|Number of buses :
|Starting Fare :
Ankleshwar to Jaipur Bus Distance
|Time taken :
|12 hours 30 mins
|Total operators :
Long journey by bus from ankleshwar to jaipur is made effortless by redBus, one of the eminent bus ticketing platform fulfilling most of the travel requirements. Numerous operators run their buses in this route creating ample amount of convenience for many people in India. Secured online ticket reservation process and easy booking techniques help every traveler to undergo smooth booking.
If you are also looking for return checkout, please ensure to checkJaipur to Ankleshwar Bus Tickets.
A number of prominent operators ply buses from ankleshwar to jaipur ensuring punctuality and safety for its passengers. Major operators offering disparate kinds of bus services are,
Most of the buses pass through various boarding terminals in the route, a few of the many popular points are:
Most of the buses stop at several drop points in the route, a few of the many popular ones are:
Various types of buses serve from Ankleshwar to Jaipur ensuring safety and comfort for travelers, a few buses services are:
You can now book route tickets from ankleshwar to jaipur at redBus.in. Apply time to time redBus offers on online bus ticket booking. Make some money and memories too!
I traveled three times in bus after booking tickets from your app and each time in every bus the switch plug was not working. They(each one) told about this same shit every time that electric wire damaged. I know that they all are lying. One more thing is that all bus staff is very frank in using of abusive language. Focus on these things IF YOU CAN. Consider this as a same feedback for my all rides.
This is the worst service I received, I felt like St bus would had been better then this. 1. The contact no. Mentioned on ticket was wrong. 2. Somehow I got the office phone no of the bus service but they picked up my call after 15 minutes of continuous calling. 3. They provided the bus driver's no. But he didn't pickup the call. 4. Bus came late by 1 hour from the scheduled time. 5. Seats in the bus were so dirty that my clothes also became dirty. 6. Driver and conductor's behaviour was very bad. 7. Bus reached to the destination late by 3 hrs. 8. They didn't drop me to the point I had mentioned in the website. I don't think I m gonna take your services again. Jayant Singh
Jaipur is byfar the most popular tourist destinations of India and forms the 'Golden Triangle' of Indian Tourism Industry together with Delhi and Jaipur. The city of Jaipur having a rich royal background charms in tourists from all corners of the world. Tourists throng to the city in large numbers to soak in the grandeur, rich culture and heritage of the region. There is plenty to see and do in the city. Some of the major sightseeing attractions of the city include the Amber Fort, Jaigarh Fort, City Palace, Jal Mahal, Jantar Mantar and Hawal Mahal among others.


text: $0.55 off any Hungry Jack® Pancake Mix or Syrup coupon Free See It! About this Deal If you would like to save ink, click "Help" near the bottom right of the printing page to get the coupon mailed to you! Flag this deal Edit deal What's the matter? Choose a reason Dead deal Duplicate Bad link Spam Inaccurate No value Alive again Comments (1) calistair Jul 23, 2013 Shouldn't this be under Coupons? I could see it being under Freebies if the coupon made the product free. Otherwise we could end up filling DP Freebies with various cents off coupons from the different coupon sites. Reply Cancel Load More Comments


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Tropical Fish Keeping - Aquarium fish care and resources (http://www.tropicalfishkeeping.com/forum.php)
- Tropical Fish Diseases (http://www.tropicalfishkeeping.com/tropical-fish-diseases/)
- - How to tell the sex of tiger barbs? (http://www.tropicalfishkeeping.com/tropical-fish-diseases/how-tell-sex-tiger-barbs-6926/)
How to tell the sex of tiger barbs?
One of my barbs has a swolen belly. Is there a way to tell if it's a female and she's pregnant? Or could this be some kind of illness?
sexually mature males have a red nose and a red trailing edge to the dorsal fin.
females tend to be more rotund in comparison to males and do not have any red on the nose or dorsal fin.
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Large goblet shaped flowers unfurl their delicate petals in spring. Grown as a standard, this beautiful deciduous Magnolia is compact enough for a pot on the patio, or as a focal point in narrow borders. Ultimate height: 150-200cm (60-80"). Ultimate spread: 90cm (36"). Supplied as a bare root plant - height of stem supplied 1m (39").
For extra value why not buy our Magnolia Standard Patio Collection, including 1 Magnolia Standard, together with a Patio Planter - a durable pot with brushed metal finish, lattice design and a large saucer, standing 30cm (12") tall and 38cm (15") wide; plus 100g of our exclusive incredibloom® Fertiliser, which will give your new Magnolia extra flower power - producing up to 400% more flowers.
Useful links:
Culinary information: The young flowers, once separated, can be pickled and then used either on their own as a treat or in salads. For more details about edible flowers click here.
By julia rumsby 19-04-2016
I purchased 2 magnolias as bare root plants, and one is obviously happy as it has signs of flowers/leaves (not sure which yet) the 2nd one (with far more branches ) is only just showing signs of life on just one of the 4/5 branches. I hope the rest are just 'taking their time' to grow, but they look very dried out. I am more than happy with my purchase and hope it is a flower this year , but cannot believe it would flower so soon. Sale and delivery were absolutely faultless. Well done !
Our Reply
" Thank you very much for your review. I am glad that you have been happy with your purchase and thank you so much for taking the time to let us know. The 2nd magnolia will soon perk up now that the better weather is just around the corner. I hope we can continue to be of service to you in the future. "
Anne - Van Meuwen
Customer Care Team
By Malgorzata Perek-Dissmann 02-04-2016
I bought the plant in Feb (fast delivery) but the tree doesn't show any signes of life! Also, I have tried to contact the customer service twice about it and...no answer! I feel that this was a complete waste of money, since no response or refund so far...Very disappointed with the plant and the customer service in this case!
Our Reply
" Thank you for your review. I am sorry to learn of your disappointment with your purchase. At your earliest convenience please contact our Customer Care Department at firstname.lastname@example.com, one of our agents will be more than happy to look in to this further for you. "
Anne - Van Meuwen
Customer Care Team


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The Hurt Locker
Days and Nights
Europa Report
The Twilight Saga: Breaking Dawn - Part 2
The Twilight Saga: Breaking Dawn - Part 1
Happy Tears
Harlem Aria
National Treasure: Book of Secrets
Lip Service
K-19: The Widowmaker
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2017 FANDANGO MOVIES.


text: Originally rooted in the tradition of hard bop jazz, cornetist Rob Mazurek developed into one of the most consistently exciting pure improvisers of his time. As a founding member of the multifaceted Chicago Underground collective and the 21st century fusion outfit Isotope 217, his playing redefined musical boundaries through vibrant sonic palettes that defy categorization. Born in 1965 in Jersey City, New Jersey, Mazurek moved with his family to the Chicago area as a preteen a... Read more


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Calcific aortic valve stenosis (CAVS) is the most common disease needed surgical valve replacement. Recent studies in human patients indicate that, rather than a "senile" or "degenerative" disease;CAVS is an active complex syndrome involving multiple cellular processes. Common cardiovascular risk factors, including age, gender, abnormal lipoprotein/cholesterol profile, hypertension, and type II diabetes are all associated with CAVD;however, the association is weak in patients over 65 years old, who have the greatest risk of progressing to aortic valve stenosis. In contrast, congenital valve abnormalities markedly increase the risk. Nearly half of the patients with aortic stenosis have a bicuspid aortic valve (BAV), the most common congenital cardiac malformation affecting 0.6% of the population. Significantly, BAV patients develop a form of rapidly progressive CAVS at an earlier age, suggesting that genetic factors are involved in the disease. However, the patients with the early stages of CAVD are symptomless and unavailable for human studies, whereas the study of the latter stages of CAVD patients is unlikely to reveal the underlying molecular mechanisms of CAVS. To fill this gap, we have developed novel mouse models of human CAVS. The overall goal of this project is to use these models to characterize the genetic pathways that regulate aortic valve biology and mediate CAVS. In this program, we will use these new models to examine whether Egfr, Notch1, and Nfatc1 forms a genetic network that maintains the biology of the aortic valve and mediate CAVS in three Aims.
Aim 1 will determine if Notch1 and Egfr signalings interact in the VECs to maintain endothelial integrity.
Aim 2 will define if Egfr protects valve from early sclerosis through Nfatc1 in the VECs.
Aim 3 will identify the common downstream effectors of Notch1, Nfatc1, and Egfr involved in CAVS. Because of their central roles in differentiation, survival, and proliferation, we believe that the newly identified interactions among Egfr, Notch1, and Nfatc1 and their common downstream targets will provide novel molecular insights into the pathogenesis of CAVS. The information would have direct implications in the development of new therapeutic strategies for this most common valve disease.
The goal of this project is to study cellular and molecular mechanisms of calcific aortic valve stenosis by using newly generated mouse models of the disease. Completion of the project will provide critical information on the underlying pathogenesis of human calcific aortic valve stenosis thereby helping develop new therapeutic and preventive strategies for this devastating human disease.
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