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Peter King, the chairman of the House Homeland Security Committee, amid scenes of emotion and anger yesterday opened controversial hearings into what he calls the radicalisation of Islam in America.
Mr King, a Republican representative from Long Island, New York, who has also been flayed in the press for past ties with the IRA when it was pursuing a campaign of violence against Britain, dismissed critics who claimed the hearings were dangerous and racist by saying said the expressions of opposition had verged on "paroxysms of rage and hysteria".
Among the first witnesses called to testify was Keith Ellison, a Muslim Congressman from Minnesota, who castigated Mr King. He broke down recalling a Muslim-American student who perished in the collapse of the Twin Towers nearly 10 years ago. The young man, he said through gasping sobs, had "given everything for his fellow Americans".
By merely convening the hearings, Mr King attracted the accusation that he and other witnesses he has called, including Dr Zuhdi Jasser, president of the American Islamic Forum for Democracy, were querying the loyalty of every Muslim American to their country and implying that as a group they should be investigated. Critics say it recalls the late Senator Joseph McCarthy's pursuit of Communists in the United States.
"This is a historic event, but historic in a negative way," said Zak Dehlawi, 24, a Saudi-American who travelled from Baltimore to sit in the public gallery. Wearing a white knitted kufi, or skull cap, Mr Dehlawi said that Mr King had "learned nothing from past history". He worried the hearings would make the assimilation of Muslim Americans harder and feed al-Qa'ida's anti-American propaganda.
"There is already a vocal minority in America that actually hates Muslims and this will only provide them with fresh ammunition to make the claim that all Muslims are a danger to American security," Mr Dehlawi said.
A defiant Mr King insisted the hearings "must go forward", because "to back down would be a craven surrender to political correctness". He showed a chart of attempted terror attacks on US soil in recent years and catalogued those hatched by domestic Muslim Americans, such as the recent Times Square plot.
"I have repeatedly said the overwhelming majority of Muslim Americans are outstanding Americans," he said. But, he continued: "This committee cannot live in denial, which is what some would have us do."
Faced with charges that his past association with the IRA disqualified him from tackling terror issues, he said comparisons between the IRA and al-Qa'ida were misplaced. "I understand why people who are misinformed might see a parallel," he said. "The fact is, the IRA never attacked the United States. And my loyalty is to the United States."
Among Mr King's witnesses was Abdirizak Bihi, the uncle of Burhan Hassan, a Somali-American who, he said, was "brainwashed" and recruited by the imams in a Minneapolis mosque to fight with the jihadist group, al-Shabaab, in Somalia, where he was killed. When Mr Hassan and some of his friends vanished and surfaced as fighters in Somalia he and his relatives "were in a state of shock that words cannot express", he said.
Dr Jasser said: "Many mosques do teach an Islam that is spiritual patriotic and not in conflict with America. But there are also many that are transmitting ideas that are Islamist."
King's IRA connections
Some have questioned why Mr King has any role in anti-terrorism matters given his history as a supporter of the IRA.
In 1982, as a local politician on Long Island, he exhorted fellow Irish-Americans to "support those brave men and women who this very moment are carrying forth the struggle against British imperialism". In 1985, he said: "If civilians are killed in an attack on a military installation it is certainly regrettable, but I will not morally blame the IRA."
In later years, Mr King was credited with using his contacts with the IRA and Sinn Fein leader Gerry Adams to assist the Northern Ireland peace process.
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- Irish Politics
- Somalia
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Seattle could soon be joining the ranks of Philadelphia, Chicago, Boulder, CO, Albany, Berkeley, CA, and a handful of other cities in charging consumers a little extra when they purchase a sugary drink. But the home of Starbucks will reportedly provide some relief for java lovers, as coffee shops will be exempt from a proposed rule on sweet beverages.
Soon-To-Be Proposed Sugary Drink Tax In Seattle Won't Apply To Starbucks
Seattle could soon be joining the ranks of Philadelphia, Chicago, Boulder, CO, Albany, Berkeley, CA, and a handful of other cities in charging consumers a little extra when they purchase a sugary drink. But the home of Starbucks will reportedly provide some relief for java lovers, as coffee shops will be exempt from a proposed rule on sweet beverages.
Washington state prosecutors are using state consumer protection laws to go after a man — already facing multiple criminal charges of rape — that they claim spent years misleading women about his job, and even his gender, with the goal of misleading women into sleeping with him in exchange for a non-existent shot at stardom. [More]
The Grocery Shrink Ray Hit Seattle Bakeries In 1916
Did you think that the Grocery Shrink Ray was a modern phenomenon? It turns out that shrinking down food and hoping that no one notices is a venerable tradition, and was front-page news in Seattle a century ago. [More]
Federal Judge Dismisses Lawsuit Against Seattle's Uber Drivers Union
Late last year, Seattle made it legal for drivers who work for ride-hailing services to organize in unions, even though this is technically against federal labor law. While that question still has to be resolved, and the law hasn't actually gone into effect yet, the U.S. Chamber of Commerce sued the city to suspend it. [More]
Amazon's New Seattle Buildings: Part Workspace, Part Arboretum
Some companies provide employees with rooms full of ping-pong or foosball tables, TVs, and comfy napping pods as a way to relax or kick-back for breaks during the day. Amazon is reportedly taking a more zen approach to inspiring workers: creating a garden/jungle/conservatory-like new workspace. [More]
Franchisees' Challenge To Seattle's $15/Hour Minimum Wage Falls Short
When Seattle city leadership voted in 2014 to approve a plan to raise minimum wage to $15/hour over the course of several years, franchisees in the city said the rules were unfair and vowed to challenge the higher wages in court. Today that challenge came to a quiet end when the U.S. Supreme Court elected to not hear the matter. [More]
Interesting Things Happen When Verizon Gives You Sir Mix-A-Lot's Old Number
If you've ever gotten a new phone line with a number that previously belonged to someone else, you know how annoying it can be to repeatedly tell callers that "No, this isn't Carl. Yes, I'm sure I'm not him. No, I can't pass him a message." But when you get the former number of a '90s rap superstar, the calls and texts are slightly more interesting. [More]
Seattle City Council Approves App-Based Drivers Unions That Can't Actually Do Anything
Should livery drivers, especially drivers who work for app-based transportation services like Lyft and Uber, have the right to organize in citywide unions? Seattle's city council voted unanimously yesterday to allow such a union, even though the city's mayor doesn't intend to sign the ordinance, which may also be illegal on the federal level. Specifically, a group of independent contractors bargaining collectively is against price-fixing laws. [More]
Chipotle's Bad Year Continues With Closure Of Seattle Restaurant For Repeated Violations
Not even two months after Chipotle temporarily closed 43 restaurants in the Pacific Northwest amid an E. coli outbreak that resulted in 52 sick customers in nine states — and the same week that a Boston Chipotle had to be shuttered after being linked to around 80 illnesses — the burrito chain has had to shutter a Seattle eatery after being repeatedly flagged for serious health violations. [More]
Philly Gets Comcast To Agree To Better Franchise Terms; Now Seattle Wants Them, Too
After a tense year of negotiations, the city of Philadelphia and one of its biggest corporate residents, Comcast, finally came to a new agreement over a cable franchise. The terms of the new 15-year contract are generally good news for Philadelphians, but now Comcast customers on the other side of the country are demanding that they get treated better, too.
Starbucks Starts Delivery Test In Seattle, Charges A $6 Fee For One Cup Of Coffee
Nearly two months after Starbucks launched a test of its "Green Apron Delivery" concept at the Empire State Building, the coffee giant's drinks have hit the streets of select Seattle neighborhoods. While the service could no doubt be a welcome convenience for some, the added fee creates a bit of sticker shock. [More]
Amazon Opens Actual Real-Life Bookstore Today In Seattle
In the last year, there have been rumors that Amazon planned to open a gadget store and package pickup center in Manhattan near the Empire State Building, and that they planned to buy the leases of some RadioShack stores when that retailer declared bankruptcy. Neither of these happened. This morning, Amazon is opening an entirely different sort of real-life store. They're selling books. [More]
If You Want To Use Amazon Fresh You'll Have To Pay $299/Year For PrimeFresh First
How much are you willing to pay to have bags of fresh produce, and other grocery items delivered to your door anytime of the year? If you live in Seattle, Philadelphia, or New York, Amazon's hoping $299/year is the magic number. [More]
Wedding Venue Fined $305K For Taking Deposits For Events It Couldn't Possibly Host
Imagine you're about to get married and then find out that the venue you booked for your reception is not only closed, but that the venue operators knew it be shutting down and took your deposit anyway. This is exactly what happened to nearly 60 people who were tricked into making deposits with a Seattle gallery for weddings and other events that could never have possibly been held there. [More]
Amazon Quietly Launches Same-Day Beer, Wine Delivery In Seattle
When you're hosting a party and notice that the alcoholic beverages are running a little low, you might momentarily panic: who in their right mind wants to leave such a great shindig to go on a beer run? No one, that's who. And now, with the long-awaited addition of alcohol delivery to Amazon's one- or two-hour Prime Now service, no one has to… unless you live outside of Seattle, in which case you still have to go to the store. [More]
Amazon's New Seattle Facility Reportedly Set To Test "Amazon Flex" Package Pickup Service
When making a purchase through Amazon there are several options for delivery, depending on where you live: free-two day shipping with a Prime membership, Sunday delivery via USPS, Prime Now one-hour delivery, drop-offs at an Amazon Locker, and, of course, traditional several-day delivery. Now, it appears the e-commerce giant is working on another, secret, service at a soon-to-open facility near Seattle. [More]
Remember Seth, the Washington state homeowner who was putting his recently purchased house up for sale because no one — not Comcast, not CenturyLink, not his county — was willing or able to provide the broadband connection he needed for his home office? We're happy to tell you that Seth is still in the house and he can now go online. [More]
Nordstrom Remodels Flagship Stores, Won't Make You Go Inside
There are two interesting developments that Nordstrom is trying right now: first, they're remodeling and fancying up their stores in Seattle, Chicago, and San Francisco, seeking to draw international tourists with world-class retail experiences. They're also experimenting with curbside order pickup, so local shoppers can pick up their online order of bras without getting out of their cars. [More]

subset: commoncrawl


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Mold needs two things to survive and spread: moisture and food. Because it's susceptible to moisture, traditional...
24/7 Listener Line: 1-888-MONEY-PIT
Unsightly nail pops can ruin the good looks of walls and ceilings, but they're simple to repair. Nail pops have a variety of causes, from installation issues to temperature changes.
In this section, learn how to fix nail pops in walls and ceilings. Get tips for drywall repair, and find out what causes nail pops.


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Want to show your appreciation for your baby shower largesse? Check out these adorable thank-you notes, all unique enough to show your gratefulness. From adorable floral postcards (believe us, when you have dozens of notes to write, less space is a good thing) to baby stationery that will take your lil one through his first birthday, these thank-yous will inspire some serious appreciation. Keep clicking to find your favorite.
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text: 12 Weirdest Moments From Superman: The MovieCharlie Jane Anders6/12/13 1:00pmFiled to: superlistsupermansuperman: the movieman of steelsuperheroesmoviesrichard donnercomics47417EditPromoteShare to KinjaToggle Conversation toolsGo to permalink GIF There's a brand new movie retelling Superman's origins, coming to theaters this weekend. But we'll always have a warm place in our hearts for Superman: The Movie... even though bits of it are hella bizarre. Here are the 12 weirdest moments from Superman's first ever movie. 1) Brando's valium acting It's kind of great that they were able to get Brando to be in this movie at all, but yeesh. He seems kind of out of it, especially in the scenes with Lara and baby Kal. He's doing sort of a Shatnerian thing of taking a long... pause... between words. But he just seems too mellow for a guy who's sending his only son off to a barbaric planet.2) The Enforcer guy I think this guy is only on the extended Blu-ray cut. The Kryptonian council send him to stop Jor-El. He looks pretty badass, and there's a lot of talk about how he'll totally sort Jor-El out. And then WE NEVER SEE HIM AGAIN. He's like the Boba Fett of the Superman movies.3) Kal-El listens to books on tapeWhile Kal is flying to Earth, he gets lots of instruction in his space capsule, including stuff like "You're flying through six different galaxies, and each one of them has its own laws of space and time." Which, I don't know what that means. Advertisement Advertisement And even though he's learning about the knowledge of 28 different galaxies — and Jor-El later says he will have been dead for thousands of years by the time Kal-El reaches Earth — most of the lessons are about China and Albert Einstein: Maybe they just wanted to have a baby flying through cosmic stuff, because they still remembered how cool the final reel of 2001 was.Later, when Kal-El is almost grown up, he gets a second course, lasting a dozen years this time. Sponsored They fly through different galaxies (in his mind, I guess) and it takes them a whole year just to understand the human heart: 4) Clark goads Pa Kent into having a heart attackFirst Clark bugs Pa Kent about not knowing his place in the world, and Pa Kent tries to invent a reason out of thin air why Clark might be here on Earth, then just gives up: GIF "I dunno. A reason, okay?" Advertisement Advertisement And then Clark forces Pa, who we've been told has a huge heart condition, to go jogging. GIF This leads immediately to Pa's fatal heart attack.5) The first reaction to Superman's public appearance GIF For some reason, a pimp is hanging out at the Daily Planet offices, with a couple of ladies in hotpants, and he gets the very first comment on Superman's costume.6) Random authority figure gives Superman some approval GIF Almost the last shot of the movie is this prison warden intoning, "This country is safe again, Superman. Thanks to you!"7) Superman causes child abuseThe girl whose kitty Superman rescues gets audibly smacked by her mom for "telling lies" about flying men. What's really sad is that Superman can probably still hear what's going on down there, thanks to his super-hearing, but he just doesn't care that much.8) Miss Teschmacher's Best Moment GIF She has some great outfits in the movie, but this is the best one. Note the big cigarette holder, and sparkly cape. Also, she sasses Lex with total aplomb.9) PINK! GIF GIF Plus he uses his fake clumsiness to execute this little maneuver: GIF 10) The "Flying Around the World" Solution. GIF Leaving aside that Superman breaks some arbitrary rule about violating history — there's just the fact that after this, he can use his "flying backwards in time" power to fix any disaster before it happens. Advertisement Advertisement Also, after Superman saves Lois, he leaves her standing on the same road she died on the first time around — and she stands around near her car for a very long time, because he didn't bother to warn her that this stretch of road is about to burst open any minute. (He didn't go back in time far enough to dispose of the missile, just far enough to get Lois out of her car.) 11) The Clouds Yelling at Superman GIF When he's about to fly around the world and make time go backwards, he hears Jor-El's voice warning him that this is a bad idea. The way he glances around as if he thinks the actual clouds are yelling at him is kind of amazing.12) Lois' Poem GIF As Lois flies around with Superman, she recites a poem in her head. It goes: Advertisement Can you read my mind?Do you know what it is that you do to me?I don't know who you are.Just a friend from another star.Here I am, like a kid out of school.Holding hands with a god. I'm a fool.Will you look at me? Quivering.Like a little girl, shivering.You can see right through meCan you read my mind?Can you picture the things I'm thinking of?Wondering why you areAll the wonderful things you are.You can fly!You belong in the sky!You and ICould belong to each other.If you need a friendI'm the one to fly toIf you need to be lovedHere I am!Read my mind.Reply474 repliesLeave a reply


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My first project, upcoming Doctor Strange movie prop replica
Thanks to everyone who volunteers training and care for the laser cutter. My son and I will have a blast taking these to the opening night.
Thanks to everyone who volunteers training and care for the laser cutter. My son and I will have a blast taking these to the opening night.
My name is Ralph, and I'm an amateur luthier and PS:1 "starving hacker".
I make all kinds of instruments: guitars, ukuleles, bouzoukis, and more, but my favorite thing to build is mandolins. They are far and away the most difficult instrument that I make, and require a level of craftsmanship not found in the simpler instruments.
There's only one real downside to building mandolins— the carving. Mandolin plates are made from 1" thick stock, carved into a very precise dome shape ranging from 3mm thick at the rim up to 6mm thick at the bridge. Making the plate accurately is the key to getting a good tone from the instrument: too thick and it sounds "dead", too thin and the top can't withstand the force of the strings.
To make the plates requires a set of inside and outside templates that show the proper curves (making these templates on the laser cutter was a primary reason I joined PS:1), using carving gouges to get close the the final shape, and then curved planes and scrapers to get the dimensions exact. There is about 40-50 hours of carving and scraping that go into a set of mandolin plates. To make things worse, the back plate is made of hard maple, which is VERY difficult to carve. Even with leather carving gloves, my hands are a mess of blisters and callouses after making a plate.
When I saw the CNC routers at PS:1, I was immediately struck by the idea of using CNC to produce a rough mandolin plate. Even if I would still need to scrape to get things perfect, the hard carving work (and blisters) would be taken care of by the machine.
Thus began a year-long journey of discovery…
I learned about CAM, and taught myself to use Fusion 360, only to discover that this 3D modeling stuff is HARD. I managed to turn out some pretty simple models for bridges and headstocks, which I was able to make on the Shapeoko and ShopBot, but every attempt at modeling a mandolin plate failed.
After flailing around for many months, I discovered the Fusion 360 meetup (sponsored by Autodesk and held at PS:1), and everything changed. With the help of Autodesk's Michael Aubrey (Fusion evangelist), and PS:1's resident CAD experts, I improved my skills to the point where I was able to make a reasonable model of the top plate for an A-style mandolin.
Last weekend, I got to test the model on the ShopBot! The initial version is in MDF, just to test the model and the machining commands. Once everything is tweaked, I will do the real thing in Sitka spruce.
Since the plate needs to be machined on both sides, I needed to create a fixture to align everything. It's a pretty straightforward plate, with two alignment pegs that match holes drilled into the ShopBot wasteboard. All of the shaping was done with a 1/2" round-nose bit running at 12000 rpm and a chip load of .35mm.
The inside is machined first, referencing the stock top. It uses a pretty simple adaptive pocket to remove most of the waste, followed by a spiral with a 1mm overlap to take things to the finished size.
You'll note that the pocket is not centered in the picture— my origin was in the wrong place in my model. I fixed that, and the second attempt came out much better. There is still a bit of scraping/sanding to remove the machine marks, but that was to be expected.
After the inside surface was machined, I flipped the workpiece over and re-registered the Z axis to the bottom of the piece. That way, I know the thickness of the part will be accurate even if my stock thickness is off by a little bit.
Once again an adaptive pocket removed most of the stock, starting with a channel around the rim.
After the rim was rough-sized, the "hump" was roughed in.
A second pass of the adaptive pocket got the rim down to 4mm thick, and smoothed the transitions.
Just as with the inside, the finishing step used a spiral to clean the surface and eliminate the tool marks. The net result was quite good, and will need only a bit of scraping to finish
After all was said and done I swapped in a 1/8" straight bit to cut the outer profile and f-holes.
Cutting off the excess stock left me with a quite nice-looking mandolin top plate! Total elapsed time (not counting my initial screwup) was about 90 minutes.
Putting my micrometer to the finished product, the results were better than I expected. Thickness is accurate within 1mm across the entire profile, with most areas within 0.5mm. That leaves only a bit of scraping to get things perfect!
Next weekend… the real thing, in sitka spruce.
Many thanks to Michael Aubrey from Autodesk, Ray Doeksen and Andrew Carmadella from PS:1, and all of the Fusion 360 Meetup crew that helped me along the way! I'm still a modeling rookie, but I've come a LONG way with your help!
Ralph Brendler
In the last days of Radio Shack, I was in a store on Michigan Avenue when I spotted, buried amongst the disassembled shelving units and discarded phone cases, a small red box that turned out to be an Arduino-based soldering project, the 2770158 LED Cube (https://github.com/RadioShackCorp/2770158-LED-Cube). I bought it for something like $5, took it home, and promptly put it on the shelf as a project I'll 'get to' at some point.
The honest truth is that I was somewhat intimidated by the soldering; it's a 3x3x3 cube of LEDs that are soldered together and the lights were smaller than i was expecting, and looking at some pics of the final result, I resigned myself to likely screwing it up and at best hoping that I might learn something from what I assumed would be a complete failure. So I somehow justified to myself that, in order to not waste my $5, I shouldn't actually try to make the thing I spent $5 on.
At some point I hit myself with a clue-by-four and realized the stupidity of my situation; accept the possible loss of the $5 and actually try instead of fretting about what-ifs. So I took the kit to PS:1, sat down in the Electronics area, got out the soldering iron, magnifying glass, and went to work. It took a couple of hours, and I was certain, absolutely positively certain, that, even though it looked right, there was no chance that I had actually gotten the leads all wired together correctly, especially the ones in the middle that were extremely hard to reach with the big tip of the soldering iron. Okay, well, only thing left was to actually plug it into the Arduino Uno I had, load up the sample sketch (available in the RS GitHub repo above), and see what happens.
I fired up the Arduino IDE, loaded the sample sketch, hit upload, and all of a sudden all the lights came on as it started through the canned routines. I was initially skeptical, checking every single light to see which one was never lighting up, and all of a sudden it dawned on me that I had actually done it, all the lights actually lit up as part of the demo routine, and HOLY CRAP I MADE A THING AND IT WORKED!!!!1111
And then in my excitement I dropped it, ripping the USB cord from the Arduino, and landed lights-down on the floor. Well, of course I did. Of course I broke it, right? But as I checked the connections, nothing had come loose, there were no broken connections. I plugged the Arduino back in, and sure enough, it happily came back to life and started going through the routine. Whew!
So I resolved to make this truly my own; running a demo program that I didn't write was not 'finishing the job'. I remembered the QBasic 'Snake' program that drew a line bouncing around the screen, hitting the edge and then randomly turning and going off into another direction. Ah, but this is a cube, in threeeee deeeeeeee, so the challenge would be that more interesting, especially as I resolved to sit down and actually try to implement it without any help from the Internet; a three-dimensional matrix of lights, translated into C++.
This is where I remembered a line from Top Gun that went something along the lines of "Our pilots had become dependent on missiles" as a reason for loss of dogfighting ability. (And then I got that Everly Brothers song stuck in my head). Well, writing C++ for years, I had become dependent on the containers provided by the Standard Template Library (map, vector, etc.). While the Arduino is programmed using C++, it's really a pretty small subset of C++ (which sort-of-kinda-not-really makes sense) and the STL is not available; go ahead and #include <map> all you like, all the compiler's gonna do is complain. So I knew I'd have to regain some amount of dogfighting capability and do all the array/matrix stuff in pure C. So I decided the best way to keep myself honest and regain some of the skills I think I used to have, I created a C file in Vim (using Emacs always made me angry, straight-up I hate this, whatever this is), wrote the program, saved, compiled and ran straight from the terminal prompt. Again and again and again.
One of the biggest problems was forcing myself to get past the 'sheesh, this woulda been easy to use <insert some STL thing> here' and just focus on getting the values in the right cells of the matrix. It took a few hours to get the algorithm right, but pretty soon I had it spitting out numbers that seemed right, but how was I gonna know that it was right?
This is where I decided to make a quick diversion and build a virtual version of the matrix in OpenSCAD:
Using this model, I could walk through the output of the program and verify that the snake was truly moving correctly around the matrix. I rotated the model around, checking that the numbers were right and HOLY CRAP I MADE ANOTHER THING THAT WORKED!
The last thing to do was to actually get the program to work with the LEDs. This is where the spartan documentation of the original Radio Shack code became a problem; the sketch did a passable job of explaining how the lights were addressed, but the examples were all arrays of pre-baked values without having to do anything dynamic, and my program was all dynamic. I studied how the demo program worked, started fiddling with the values, and discovered how to set the bits in the right way to turn on individual lights, on specific levels. From there I modified my C program and added some code to translate my positioning, which turned out to be the mirror opposite of the way the lights are addressed; I solved the problem by physically turning the Arduino around so I was looking at the other side. Problem solved!)
I uploaded my sketch to the Arduino and it suddenly the lights were lighting up in what appeared to be a snake moving around the matrix. HOLY CRAP I GOT IT TO WORK!!!!!!11111
This is a long post for what amounts to a small light toy, but whilst I was feeling rather verbose (a consequence of sitting and waiting for an unrelated program to finish), I can't emphasize how foolish I feel for not starting all this earlier; fear of failure is a very, very powerful emotion and if there's a TL;DR in here somewhere, it's that it is always better to try and fail than to never try at all, which is something PS:1 has done a very good job of teaching me.
The code is available at https://github.com/tachoknight/arduino-snakey.
A good friend of mine had the vision to make a memorial to lost cats at Burning Man 2016. It would be a whimsical project with a deeper side to it to honor our fallen feline companions. To see more of what is behind the project can go to see the Spacecats Indiegogo at https://www.indiegogo.com/projects/art-installation-for-burning-man-spacecats#/ . I was asked by her to assist with creating the rocketship part of the project for the intrepid spacecats. I just starting doing CNC work this year and leaped at the opportunity to further improve my skills with a big project. Over a period of 2 months many models were created to arrive at the final form. I will detail the workflow for this and share some of the iterations!
It all started with Fusion 360, a great program for makers, to create a basic rocketship model. Well, I thought it was basic but my inexperience made it a bit harder than expected and went through many hours of "learning time" to arrive at a model I was happy with. From making the 3d model in Fusion 360, I then took it to 123d Make to have it piece together in radial slices so that it can be put together in real life! With the parts generated from 123dMake I was able to create some laser models to show my friend and get her input for her vision. As you can see it took about 4 times to get it right. These models were done 1:10 scale then 1:7 scale. it really helps to have something in front of you to decide what will look best.
After finally arriving at a model that was good it was time to bring it to the shopbot for a 1:2 model (that is also one of the indiegogo rewards!). There was much dialing in to make sure that the slot fit was tight but not too tight to be able to fit the pieces together. Found that adding in .01 helped immensely to get the perfect fit. I did many test notch pieces to ensure the fit. One problem I had was making the test pieces too small so it did not get the full effect of sliding all the way into the wood. I found that making them larger really helped. It paid off to prototype and make test pieces , saved me from wasting many materials , especially when I moved to the more expensive wood! Finally, we had something that the Spacecats seemed somewhat happy about – other than that orange tabby Floyd at least!
Also learned how to use a V bit for this project , very challenging to get the right font in so that it looks nice but was not too thin. This is the plate with the names of departed cats.
And finally , was able to do the full-size model that will go out to burning man! They were displayed at an event last weekend that was a Hawaiian luau, they seemed pretty pleased with it if I do say so myself!
Thanks to everyone at PS:One for the patience to answer many of my questions and excessive use of the shopbot to dial this project in 😀
If curious about the indiegogo project and the other elements of the installation can check out the page at Spacecats . And if going to Black Rock City this year, look for some spacecats in the deep playa!
A while back I built a pair of sound-reactive LED towers which were on display a few times, at some local Chicago events.
To plug into the DJ mixer output required a relatively expensive device to get the stereo signals (with external gain control) seen by a computer running processing.org as a microphone input. Also, it was a relatively bulky affair to have yet another laptop sitting next to the mixer when the artist wasn't using it to make the music.
Recently I discovered that starting with the 3.1 release, Processing can now run on a Raspberry Pi and has built-in ability to manipulate the GPIO ports. This blog entry highlights the release. This is exciting news as now the laptop can be replaced by a Pi 3 with a small touchscreen.
Here is a video of the light towers in action.
The towers each have 8 panels with 60 individually addressable RGB LEDs. These pictures show off more of the visual esthetic and the cutaway view reveals something of the construction. The LED strips are hidden in a channel in the wood supports which side illuminate acrylic panels (backed with just a strip of white cardboard). The acrylic is impregnated with a diffuser which reflects the edge-lit light 90 degrees to exit out of the faces of the panels. The white cardboard reflects the 1/2 of the light that would otherwise be directed inwards. The acrylic is produced by Evonik and is called Acrylite EndLighten. The towers themselves only require 110 VAC power. The data frames to control the LED strips are sent wirelessly from the processing script using an Open Pixel Control module which maps points on the processing screen into frames sent to a Fadecandy server running inside a OpenWRT Wifi device which is then physically connected to a Fadecandy board. I used TP-Link TL-MR3040 WiFi devices to run OpenWRT and added the Fadecandy server application into the img file used to reflash the WiFi devices. The Fadecandy GIT repository can be found here.
This is the assembled Raspberry Pi 3 w/ 2.8″ TFT Capacitive Touchscreen mirroring the HDMI frame buffer in a Zebra case without the top cover.
There were a lot of possible paths to follow in getting this build working the way I wanted it to be. Most of my Google searching turned up outdated examples, particularly due to the changes introduced in the 4.4 kernel with /boot/config.txt use of overlays. Adafruit had this very nice looking tutorial of how to get the touchscreen working with their version of the Jassie Raspbian os image. The inclusion of how to use FBCP was of particular interest as mirroring the HDMI output is important for displaying processing scripts with the 2D or 3D graphics libraries. Their Raspbian image was based on an older kernel and updating the os (sudo apt-get update; sudo apt-get dist-upgrade) turned out not to just work.
After much tinkering, these are the steps that worked for me. (note that I working with OSX 10.11)
#!/bin/bash iwconfig wlan0 power off
# match console size framebuffer_width=640 framebuffer_height=480 # force 640x480 VGA on HDMI hdmi_force_hotplug=1 hdmi_group=2 hdmi_mode=4 # 2.8" Capacitive 320x240 Touchscreen dtoverlay=pitft28-capacitive,rotate=90,speed=80000000,fps=60 dtoverlay=pitft28-capacitive,touch-swapxy=true,touch-invx=true
SUBSYSTEM=="input", ATTRS{name}=="ft6236", ENV{DEVNAME}=="*event*", SYMLINK+="input/touchscreen"
xserver-command=X -s 0 -dpms
The touchscreen should now display the 640×480 desktop scaled down to the 320×240 PiTFT screen. This makes things look less crisp but has the advantage that connecting to an external HDMI display will work and that most apps need the larger dimensions be usable. Note that many HDMI displays will not be able to handle a 320×240 HDMI signal.
FBCP stands for frame buffer copy, which rescales and mirrors the HDMI framebuffer (/dev/fb0) onto the PiTFT framebuffer (/dev/fb1)
The version of the 2.8″ PiTFT I got from Adafruit, comes with 4 buttons and I created this test Python script to demonstrate not only how to use the RPi.GPIO library, but how to manipulate the PiTFT backlight (so as to not burn-in the screen), use multi-threaded event handlers, and shutdown the os to safely disconnect the power.
I created this script as: /home/pi/pitft_buttons.py (chmod +c pitft_buttons.py to make it executable) and test by typing ./pitft_buttons.py. Note that pressing the bottom right button (#27) will ask for authentication for powering off the Pi. See below to set this script running as a service, in which case, the user will not be asked for authentication.
#!/usr/bin/env python2.7 # example code tested with Pi 3 # Raspibian Jassie (4.4 kernel): https://www.raspberrypi.org/downloads/raspbian/ # Adafruit 2.8" Capacitive Touchscreen: https://www.adafruit.com/products/2423 # for running on startup see: https://learn.adafruit.com/running-programs-automatically-on-your-tiny-computer/systemd-writing-and-enabling-a-service # make sure to update the ExecStart= entry in the Adafruit script after copying from the example import subprocess import time import RPi.GPIO as GPIO # list of BCM channels from RPO.GPIO (printed on the Adafruit PCB next to each button) channel_list = [17, 22, 23, 27] backlightOn = True # event handler to toggle the TFT backlight def toggleBacklight(channel): global backlightOn if backlightOn: backlightOn = False backlight.start(0) else: backlightOn = True backlight.start(100) # event handler to manage button presses def buttonEvent(channel): startTime = time.time() while GPIO.input(channel) == GPIO.LOW: time.sleep(0.02) print "Button #%d pressed for %f seconds." % (channel, time.time() - startTime) # event handler to manage Pi shutdown def poweroff(channel): startTime = time.time() while GPIO.input(channel) == GPIO.LOW: time.sleep(0.02) if (time.time() - startTime) &amp;gt; 2: subprocess.call(['poweroff'], shell=True, stdout=subprocess.PIPE, stderr=subprocess.PIPE) # initialize GPIO library GPIO.setmode(GPIO.BCM) GPIO.setup(channel_list, GPIO.IN, pull_up_down=GPIO.PUD_UP) GPIO.setup(18, GPIO.OUT) backlight = GPIO.PWM(18, 1000) backlight.start(100) print "Button #17 exits." print "Button #22 toggles the TFT backlight." print "Button #23 displayed the time the button is pressed." print "!!! Pressing button #27 for at least 2 seconds, powers down the Pi !!!" GPIO.add_event_detect(22, GPIO.FALLING, callback=toggleBacklight, bouncetime=200) GPIO.add_event_detect(23, GPIO.FALLING, callback=buttonEvent, bouncetime=200) GPIO.add_event_detect(27, GPIO.FALLING, callback=poweroff, bouncetime=200) try: GPIO.wait_for_edge(17, GPIO.FALLING) print "Exit button pressed." except: pass # exit gracefully backlight.stop() GPIO.cleanup()
To install pitft_buttons.py as a service,
# pitft_buttons service file, start a daemon on startup # file: /etc/systemd/system/pitft_buttons.service [Unit] Description=Start PiTFT buttons daemon [Service] RemainAfterExit=true ExecStart=/usr/bin/python -u /home/pi/pitft_buttons.py [Install] WantedBy=multi-user.target
Run a processing sketch from a script or from a terminal window or ssh session.
$ DISPLAY=:0 processing-java –sketch=/home/pi/HelloWorld –present
I recently completed my most ambitious ShopBot project to date: casting a concrete birdbath bowl in a mold that I CNC'd. This was also my first attempt at producing a video about a project as I'm working on it. Watch the video below:
You are rent/own a condo/apartment and you want a smart thermostat to keep track of your spending on heat/cool, or want a thermostat with remote sensor support. You pulled the current thermostat off the wall and looked at the wiring and you have a 4 wire system (R, Y, G, W) but no 'C-Wire' and the thermostat you want to use requires a 'C-wire' but you don't have one. You look at the Ecobee3 that supports 4 wire systems but you don't have access to the HVAC unit because its in a locked closet/on the roof and you don't want to have to deal with your landlord/association to get access to it as it probably means having to spend a few hundred more bucks to have a professional installer do the work. Don't worry though you can still have that smart thermostat you want, but it's gonna be a little ugly but you can still have what you want.
What is a 'C-Wire' and why do thermostats need them?
HVAC control systems are based on 24V AC control signals, in a combined heat/cool unit you have 4 or 5 wires (we are going to concentrate on the 4 wires here because if you had 5 then you probably would not be searching for a solution for this problem. In a 4 wire system you have one common supply wire (R) when the thermostat wants to request a function from your HVAC unit it connects one of the other 3 wires to the common supply wire to complete the circuit for that feature. 4-Wire 'pins'
The 5th wire in the system is C this is the second common wire and is connected to the other side of the 24V transformer in the HVAC control system, its used to power accessories such as a thermostat. Your system probably does not have a C-Wire as your thermostat is battery powered. 'So how does the Nest manage to work without the c-wire?' I hear you ask, well it scavenges power to charge an internal battery/capacitor by using G wire in short bursts to complete its charging circuit. 'Ok so why don't other thermostats do that?' Well if your HVAC system is to sensitive it can cause your fan to turn on and off for very short periods of time, this can be very bad for the longevity of your blower motor.
Imagine this simplified control board diagram:
So can't I just hook up a second PSU to the thermostat and hook it up from R to C?
Short answer, no! Long answer if you are are VERY VERY VERY sure that the phases of your HVAC unit and the outlet you use are in sync it is a very bad idea to just hook up a second PSU to the system, you will damage both your thermostat and HVAC control board.
So what is the solution?
To get the system to work you have to create an interface that will mimic a thermostat to the HVAC control board and mimic a 5 wire HVAC control board to your smart thermostat. To do this we need 3 relays with a coil voltage of 24V AC, a 24V AC PSU, some screw terminals, a proto-board and some form of case. I used the following relays and PSU:
Once you have the parts you need to assemble the following circuit:
Put it in a case and hook it up to your system. Now you can enjoy your 5-wire requiring thermostat with your 4 wire controlled HVAC system.
You should also design a better wall mounting solution into your case so you don't have to use blue painters tape to hold it to the wall, this will be being rectified with some double sided foam mount tape in the future.
Mohamed Dardiri took a professional looking photograph of a laser cut design he made and it was getting likes on Pinterest within minutes. You can do this, too! Photographing small projects using one of our light cubes gives you a nice, even lighting without any harsh shadows.
Here's a summary of my coffee table project that many of you have seen me work on (or struggle with) over for the last several months.
I like furniture that can flex or modify it's position to address different needs. I've seen coffee tables that raise to eating height before, but I wanted to design one that really expresses the mechanism and plays up the physics behind it. Back in October I made a 1/2 scale mock up of the design to understand the motion.
Then it was back to designing a full size mock-up.
I realized it wasn't going to be stable enough with just one set of arms, so I decided two sets would still look good. Everything was designed in Autodesk Revit. The software allows you to figure out volume, then with a given density of materials I could get weights from the various parts. This allowed me to determine the balance. I didn't want it to be perfectly balanced with the counter-weight, but have enough weight to assist the movement.
First I started making the frame out of aluminum. It's fastened using a pneumatic riveter.
Painting the steel arms.
CNC cutting the concrete forms out of pink foam
Creating the concrete counter-weight form
Failed attempt to CNC cut aluminum for brackets. I'll skip the rest of these struggles…
Casting the concrete base
Casting the counterweight (nice and sloppy)
The base assembled.
Frame is attached.
There were many tweaks after testing it. There was some wiggling around the axles, so I widened the holes in the steel arms to put nylon sleeve bearings in for a tighter smoother fit. There was still some shifting after putting some weight on the front, so I designed a locking mechanism with a latch.
Lots of struggle with this latch at the top of the photo. (FYI, learn the cold metals milling machine if you need a part like this)
And finally… a video…
By Josh Myers
This Saturday, April 30th, we will meet at 9pm in the shop to discuss our entry into the Power Racing Series. Its a friendly competition between hackerspaces where we modify ride on kids toys and race them at Maker Faires. We have a car that works great but is in need of TLC. We have a race in San Mateo in a few weeks time and need to get it ready. We will be discussing what needs to be done for that race and races to come. If you have experience with welding, electronics, fabrication, you are more than welcome. If you don't have experience, come by and get some. Read the rest of this entry →


text:
Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition
DOI: 10.1186/ar4416
© Meusch et al.; licensee BioMed Central Ltd. 2013
Received: 9 August 2013
Accepted: 28 November 2013
Published: 20 December 2013
In vitro apoptosis of peripheral monocytes in rheumatoid arthritis (RA) is disturbed and influenced by cytokine production and transmembrane TNF (tmTNF) reverse signaling. The goal of the study was the analysis of the predictive value of the rate of in vitro apoptosis for the therapeutic response to anti-TNF treatment.
Spontaneous and tmTNF reverse signaling-induced apoptosis were determined in vitro in monocytes from 20 RA patients prior to initiation of therapeutic TNF inhibition with etanercept, and the subsequent clinical response was monitored.
Spontaneous in vitro apoptosis was significantly reduced in RA patients compared to controls. Deficiency in spontaneous apoptosis was associated with an insufficient therapeutic response according to the European League Against Rheumatism (EULAR) response criteria and less reduction of the disease activity determined by disease activity score (DAS) 28. High susceptibility to reverse signaling-induced apoptosis was also associated with less efficient reduction in the DAS28. Of note, a strong negative correlation between the two apoptotic parameters was discernible, possibly indicative of two pathogenetically relevant processes counter-regulating each other.
tmTNF reverse signaling induced in vitro production of soluble IL1-RI and IL-1RII only in monocytes not deficient in spontaneous apoptosis, and the levels of soluble IL1-RII were found to be predictive of a good clinical response to Etanercept.
Although tmTNF reverse signaling is able to induce apoptosis of RA monocytes in vitro, this process appears to occur in vitro preferentially in patients with suboptimal therapeutic response. Resistance to spontaneous in vitro apoptosis, in contrast, is a predictor of insufficient response to treatment.
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting diarthrodial joints of hand and feet, but clinical patterns vary widely. Inflammatory synovitis and subsequent joint destruction in RA is to a large extent driven by the monocytic cytokines TNF, IL-6 and IL-1β. Therapeutic cytokine inhibition, and in particular inhibition of TNF, is highly effective in a high percentage of patients. The precise mode of action of therapeutic TNF blockade is not clear, and several mechanisms have been suggested. Neutralization of soluble as well as membrane-anchored TNF is believed to be the primary mechanism behind the clinical efficacy in preventing joint destruction, but as an alternative mode of action of TNF-blocking agents, outside-to-inside signals through transmembrane TNF-alpha has also been suggested[1, 2]. The latter is likely to contribute to certain anti-TNF effects exerted on immune cells such as migratory inhibition[3] and increased apoptosis[4].
Recently, our group was able to identify profound differences in monocyte apoptosis between RA patients and healthy donors. Monocytes from healthy controls undergo spontaneous apoptosis (SIA) in vitro at considerable rates during incubation over 16 hours. In monocytes from RA patients, SIA is significantly reduced[5]. Deficient spontaneous in vitro apoptosis has also been reported by other groups for peripheral monocytes from patients with systemic juvenile idiopathic arthritis[6] and for monocytic cells from the rheumatoid synovium[7, 8].
In addition to deficient SIA, monocytes from RA patients are also abnormally susceptible to in vitro apoptosis induced by incubation with TNF-blocking agents. The in vitro mode of action of those agents is ligation-triggered reverse signaling (RS) of the transmembrane TNF molecule (tmTNF)[9], which induces the in vitro apoptosis (tmTNF reverse signaling-induced apoptosis, tmTNF RSA)[5]. One mechanism leading to tmTNF RSA is the inhibition of the excessive IL-1β secretion of RA monocytes via tmTNF RS[5].
Several members of the IL-1 family of cytokines and receptors are involved in the pathogenesis and the regulation of disease activity in RA. IL-1β is overexpressed in arthritic joints, and therapeutic inhibition of IL-1β with anakinra is an established treatment option. IL-1β (as well as IL-1α) binds to the transmembrane ligand-binding chain of the IL-1 receptor (termed IL-1R type I) as well as to the IL-1 receptor type II (IL-1RII), which lacks a cytoplasmic domain and functions as a decoy receptor for IL-1β[10, 11]. Both receptors can be released from the cell surface in a soluble form as IL-1sRI and IL-1sRII, but increased neutralization capacity had been shown for IL-1sRI[12].
In the present study, we have investigated both spontaneous in vitro apoptosis and consequences of tmTNF RS in a cohort of RA patients, treated subsequently with the TNF inhibitor etanercept. The results show that the RA-specific, abnormal in vitro apoptosis of RA patients is a predictor of their subsequent clinical response.
Patients and study design
The design of the clinical study had been approved by the ethics committee of the University of Leipzig, and informed consent was obtained from each patient before study enrollment. A total of 33 patients with RA according to the revised criteria of the American College of Rheumatology[13] was recruited. None of the patients had previously been treated with TNF inhibitors. Ten healthy donors served as controls. For the initial pre-study cohort, 13 patients with a mean age of 64 years and mean disease duration of 16 years were recruited: 11 of these patients (78%) were seropositive for rheumatoid factor IgM (RF IgM), and 9 patients (75%) had anti-cyclic citrullinated peptid (anti-CCP) antibodies.
In the longitudinal clinical study, 20 patients were initiated on treatment with etanercept due to clinical requirements and clinical and laboratory parameters of disease activity were monitored at baseline and throughout the study. In this cohort, the mean age was 53 years, and the mean disease duration was 4 years: 65% of the patients were RF IgM-seropositive, and 80% had anti-CCP antibodies. At baseline, 80% (16 patients) were treated with conventional disease-modifying anti-rheumatic drugs (DMARDs), given either as monotherapy or in combination, and 20% received low-dose glucocorticoids only. All patients were treated with non-steroidal anti-inflammatory drugs (NSAIDs) for symptomatic relief. All concomitant medication remained unchanged upon initiation of etanercept treatment and throughout the study.
Monocyte isolation, cell culture and cell stimulation
Monocytes from peripheral blood were separated as previously described[9]: 2 × 105 monocytes per 200 μl were incubated in Roswell Park Memorial Institute medium (RPMI) 1640 supplemented with 5% human AB serum (heat inactivated). Stimulation of cells was carried out either with 100 mg/ml rituximab (Roche, Basel, Switzerland) as an IgG control or with the soluble TNFR2:Ig construct etanercept (Pfizer, New York, NY, USA) for 16 hours.
Apoptosis detection
Staining of apoptotic and necrotic cells was performed by using 10 μl allophycocyanin-labeled Annnexin V (Southern Biotechnology, Birmingham, AL, USA) and 50 μg/ml propidium iodide (IP), respectively. Fluorescence was measured on the FACSCalibur system, and the results were analyzed using FlowJo software (Tree Star, Inc, Ashland, OR, USA).
Cytokine detection
Cytokine levels in cell culture supernatants were measured with cytometric bead arrays (BD biosciences, Franklin Lakes, NJ, USA) according to the manufacturer's protocol.
For statistical analysis, graphPad Prism software (GraphPad Software, La Jolla, CA, USA) was used. Prior to all comparisons, a normality test was performed. To assess statistical significance, Student's t-test (normal distribution of data) or the Mann–Whitney rank sum test (unequal distribution of data) was used. Correlation between two parameters was analyzed with Pearson's product–moment correlation.
The soluble TNFR2: Ig construct etanercept triggers tmTNF RSA in RA monocytes
Deficient SIA is a predictor of insufficient therapeutic response
Baseline and week-12 characteristics in patients
All patients
Week 12
Responder (week 12)
Nonresponder (week 12)
All patients
TJC of 28 joints
8.25 (±7.2)
9.20 (±8.7)
7.30 (±5.8)
3.16 (±3.3)
2.20 (±3,2)
4.22 (±3.3)
SJC of 28 joints
5.45 (±3.7)
5.90 (±3.1)
5.00 (±4.3)
1.79 (±2.7)
0.70 (±1.9)
3.00 (±3.1)
VAS general disease activity
47.8 (±20.4)
52.6 (±19.3)
42.9 (±21.4)
27.6 (±18.6)
21.6 (±16.9)
34.2 (±19.1)
ESR, mm/h
23.7 (±13.6)
19.1 (±10.5)
28.3 (±15.3)
17.8 (±14.2)
11.1 (±7.3)
25.1 (±16.7)
C reactive protein, mg/dl
7.22 (±6.5)
6.65 (±4.9)
7.79 (±8.0)
5.40 (±8.9)
2.71 (±3.1)
8.3 (±12.3)
4.76 (±1.2)
4.82 (±1.2)
4.7 (±1.2)
3.33 (±1.4)
2.50 (±1.1)
4.17 (±1.2)
Age, years
53.65 (±9.4)
53.5 (±10.7)
53.8 (±8.5)
Sex, female, %
Disease duration, years
Rheumatoid factor, +/-, %
Anti CCP, +/-, %
tmTNF reverse signaling induces secretion of IL-1sRI and IL-1sRII in vitro only in monocytes susceptible to high SIA
For IL-1sRII, a significant negative correlation of the concentrations induced by tmTNF RS with the reduction in the DAS28 after 12 weeks was detected (Figure 3D), whereas a similar trend for IL-1sRI did not reach statistical significance (R = -0.333; P = 0.177).
High susceptibility of monocytes to tmTNF RSA at baseline is associated with insufficient therapeutic response
The goal of our study was the investigation of spontaneous and tmTNF RS-induced monocyte apoptosis in RA patients before the initiation of therapeutic TNF blockade, followed by a longitudinal analysis of the clinical response. In this longitudinal analysis, a significant influence of decreased SIA on the clinical response to anti-TNF was revealed. The SIA of monocytes from patients with a good clinical response was higher than from nonresponders and comparable to the healthy controls in the pre-study investigation. Deficient SIA, on the other hand, was predictive of an insufficient therapeutic response, suggesting that monocyte apoptosis might also be involved in therapeutic response to TNF blockade. As the patients were not initiated on any conventional DMARD therapy in the study, we can only speculate upon the contribution of SIA towards methotrexate (MTX) response.
Resistance to in vitro apoptosis has been described to occur as a consequence of activation of human monocytes[15]. As several signs of activation of monocytes in RA have been described[16, 17], this mechanism could indeed contribute to the observed decrease of SIA in RA patients. Accordingly, we have reported previously that the deficient SIA of RA monocytes is partly due to increased spontaneous IL-1β secretion and constitutively activated NF-kB signaling[5]. Therefore, activation of circulating monocytes is a likely cause for the deficient SIA in half of the study cohort, and might also contribute to the unfavorable therapeutic outcome in those patients. In addition, overexpression of anti-apoptotic molecules such as FLIP[7] or self-sustained NF-kB activation[18] have been described in RA, which could further reinforce resistance to apoptosis. An alternative hypothesis would be the existence of an RA-specific apoptotic defect, which aggravates the disease due to survival of pro-inflammatory monocytes.
tmTNF RS induces several effects in RA monocytes. One previously unknown finding of our study was the secretion of both type I IL-1sR (IL-1sRI) and type II IL-1sR (IL-1sRII) into the supernatant of monocytes following TNFR2:Ig-triggered tmTNF RS. This is in contrast to a previous publication reporting that treatment with TNFR2:Ig has no influence on the expression of cell surface IL-1RII in vivo[19], but circulating or local levels of IL-1sRII had not been determined in that study.
IL-1sRII is known to bind IL-1β with higher avidity than IL-1sRI, while not interfering with the binding of IL-1 receptor antagonist (IL-1RA)[20]. IL-1sRII has also been reported to be expressed in higher concentrations in the synovial fluid of RA patients[20]. Importantly, the simultaneous addition of IL-1sRII and IL-1RA to cultures of synovial cells leads to a synergistic inhibitory effect on the secretion of interstitial collagenase and prostaglandine E2 (PGE2)[21], indicating a potentially relevant role for IL-1sRII in the rheumatoid synovium in vivo. In an analogous conclusion, shedded IL-1sRII has also been suggested to act locally by dampening colonic inflammation in Crohn's disease[22].
The essential role of the IL-1β-IL1-R system for the RA-specific resistance of monocytes against SIA was confirmed in the present study, when a positive correlation between the tmTNF RS induced IL-1sRI secretion of monocytes and their spontaneous apoptosis became apparent. This correlation indicates that the ability of cells to respond to tmTNF RS with production of IL1sRI is linked to their susceptibility to spontaneous apoptosis. One possible explanation is, that the cells prone to spontaneous apoptosis are also the ones shedding IL-1sRI upon triggering of tmTNF RS. Indeed, high concentrations of IL-1sRI and IL-1sRII were detectable only in monocytes with high spontaneous apoptosis (that is, in monocytes from patients with a good therapeutic response), which indicates that IL-1R secretion might also be beneficial in vivo. The close correlation between IL-1sRII and the decrease in the DAS28 indicates that IL1R secretion might also be therapeutically relevant.
The observed negative correlation between SIA and tmTNF RSA indicates that the latter only occurs in patients with a pathologic resistance to spontaneous apoptosis. In healthy controls, tmTNF RSA cannot be triggered[5], and patients with low tmTNF RSA were also the ones with a good clinical response to anti-TNF therapy. Nevertheless, this lack of tmTNF RSA in anti-TNF responders in vitro does not exclude a contribution of tmTNF RSA to the clinical efficacy of TNF blockade in vivo. In the synovial membrane, TNF blockade has indeed been linked to monocyte/macrophage apoptosis[23], although other studies detected no immediate monocyte apoptosis in the peripheral blood or the rheumatoid synovium following anti-TNF antibody infusion[24, 25]. The latter would argue against a therapeutic effect of tmTNF RSA, which might instead be an indicator for the pathological state of activation of monocytes in RA. Similarly, RA monocytes are also characterized by expression of tmTNF, which correlates with the rate of tmTNF RSA, whereas monocytes from healthy donors do not express tmTNF on their cell surface[5]. Accordingly, the lack of tmTNF RSA in anti-TNF responders could be the result of a lack of tmTNF expression in those patients, which in turn might be an indicator of less severe disease.
Finally, tmTNF RS could also be part of a pro-inflammatory pathway, which is aggravating the course of RA, possibly during direct cell-cell contact[9]. Consequently, the non-responders to therapeutic TNF blockade could be the patients in whom those pro-inflammatory effects of tmTNF ligation by therapeutic anti-TNF compounds outweigh the beneficial effects of TNF blockade. Accordingly, RS in non-responders can induce apoptosis in vitro, but might still be deleterious to the patient due to those pro-inflammatory effects. Consequently, high rates of tmTNF RSA predict poor therapeutic response.
Authors' information
Undine Meusch and Maria Klinger share the first authorship. Manuela Rossol and Ulf Wagner share the senior authorship.
Cyclic citrullinated peptide
C-reactive protein
Disease activity score
Disease-modifying anti-rheumatic drug
Erythrocyte sedimentation rate
European League Against Rheumatism
Interleukin 1 receptor
Interleukin 1 receptor antagonist
Non-steroidal anti-inflammatory drug
Propidium iodide
Rheumatoid arthritis
IgM rheumatoid factor IgM
Reverse signaling
Reverse signaling-induced apoptosis
Spontaneous induced apoptosis
- tmTNF:
Transmembrane tumor necrosis factor
- tmTNF RSA:
tmTNF-reverse signaling-induced apoptosis
Tumor necrosis factor
Tumor necrosis factor receptor 2
Ig tumor necrosis factor receptor 2:immunoglobulin fusion protein
Visual analog scale.
The work was supported by the Deutsche Forschungsgemeinschaft DFG (RO 4037/1-1).
Authors' Affiliations
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- Makrygiannakis D, Catrina AI: Apoptosis as a mechanism of action of tumor necrosis factor antagonists in rheumatoid arthritis. J Rheumatol. 2012, 39: 679-685. 10.3899/jrheum.110974.View ArticlePubMedGoogle Scholar
- Meusch U, Rossol M, Baerwald C, Hauschildt S, Wagner U: Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1beta production and deficient apoptosis of rheumatoid arthritis monocytes. Arthritis Rheum. 2009, 60: 2612-2621. 10.1002/art.24778.View ArticlePubMedGoogle Scholar
- Srivastava S, Macaubas C, Deshpande C, Alexander HC, Chang SY, Sun Y, Park JL, Lee T, Begovich A, Mellins ED: Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis. Clin Immunol. 2010, 136: 257-268. 10.1016/j.clim.2010.04.003.PubMed CentralView ArticlePubMedGoogle Scholar
- Perlman H, Pagliari LJ, Liu H, Koch AE, Haines GK, Pope RM: Rheumatoid arthritis synovial macrophages express the FAS-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein and are refractory to FAS-mediated apoptosis. Arthritis Rheum. 2001, 44: 21-30.View ArticlePubMedGoogle Scholar
- Niederer F, Ospelt C, Brentano F, Hottiger MO, Gay RE, Gay S, Detmar M, Kyburz D: SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis. 2011, 70: 1866-1873. 10.1136/ard.2010.148957.View ArticlePubMedGoogle Scholar
- Rossol M, Meusch U, Pierer M, Kaltenhäuser S, Häntzschel H, Hauschildt S, Wagner U: Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells. J Immunol. 2007, 179: 4239-4248.View ArticlePubMedGoogle Scholar
- Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, Giri JG, Dower SK, Sims JE, Mantovani A: Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science. 1993, 261: 472-475. 10.1126/science.8332913.View ArticlePubMedGoogle Scholar
- Dinarello CA: Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 2011, 117: 3720-3732. 10.1182/blood-2010-07-273417.PubMed CentralView ArticlePubMedGoogle Scholar
- Symons JA, Young PR, Duff GW: Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist. Proc Natl Acad Sci USA. 1995, 92: 1714-1718. 10.1073/pnas.92.5.1714.PubMed CentralView ArticlePubMedGoogle Scholar
- Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JMW, Hobbs K, Huizinga TWJ, Kavanaugh A, Kay J, Kvien T, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E: 2010 rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative initiative. Ann Rheum Dis. 2010, 69: 1580-1588. 10.1136/ard.2010.138461.View ArticlePubMedGoogle Scholar
- Van Gestel AM, Prevoo ML, Hof MA V 't, Van Rijswijk MH, Van de Putte LB, Van Riel PL: Development and validation of the European league against rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American college of rheumatology and the world health organization/international league against rheumatism criteria. Arthritis Rheum. 1996, 39: 34-40. 10.1002/art.1780390105.View ArticlePubMedGoogle Scholar
- Waldmann TA: Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE. Proc Natl Acad Sci. 1998, 95: 14308-14313. 10.1073/pnas.95.24.14308.PubMed CentralView ArticlePubMedGoogle Scholar
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- Wright HL, Chikura B, Bucknall RC, Moots RJ, Edwards SW: Changes in expression of membrane TNF, NF-(kappa) B activation and neutrophil apoptosis during active and resolved inflammation. Ann Rheum Dis. 2011, 70: 537-543. 10.1136/ard.2010.138065.View ArticlePubMedGoogle Scholar
- van der Poll T, Coyle SM, Kumar A, Barbosa K, Agosti JM, Lowry SF: Down-regulation of surface receptors for TNF and IL-1 on circulating monocytes and granulocytes during human endotoxemia: effect of neutralization of endotoxin-induced TNF activity by infusion of a recombinant dimeric TNF receptor. J Immunol. 1997, 158: 1490-1497.PubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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SteveR's Event Journal
Friday February 14, 2014 / 8:00pmNapoli!
2 tickets
How was your experience?
Struggling to see how this ever got to the stage. Acting was ok, but the story itself just didn't develop. I was hoping it would get better during the second act but wasn't to be ... so many scenes with weak dialog. Don't waste your time.


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Everybody needs one of these. This 3" durable aluminum line level has special hooks which allows level to slide freely on string line for easy positioning. Bottom is flat for surface leveling.
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June 7th- Maggie McCabe & Reed Schwallie
June 14th- Brass Quartette LSO
June 21st- Amazing Clark and CSB Bank Ice Cream Social (Ice Cream Social begins at 6pm)
June 28th- Arts and Scraps Mobile and the Ruth Hughes Library
July 5th- 3rd Degree Burns
July 12th Allie Louise
July 19th- Rich Eddys Rockin Oldies
A vibrant arts and cultural scene is important to strong communities and Michigans excellent quality-of-life, and ultimately, to Michigans economy.
The Michigan Council for Arts and Cultural Affairs (MCACA) strengthens arts and culture in Michigan by increasing its visibility; supporting arts education; encouraging new, creative and innovative works of art; and broadening cultural understanding. A key conduit for arts and cultural information, MCACA is also a source of arts and culture grant funding.


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News By Tag
* HR Employee Engagement NC
* Seminar
* Winston-salem
* Profits
* People
* Priorities
* p3
* Ladd HR Strategy
* Raleigh
* Charlotte
* More Tags...
Industry News
News By Location
Industry News
Ladd HR Strategy Announces New Employee Engagement Series, P3 – People, Priorities and Profits
The P3 series will be held in Charlotte, Raleigh and Winston-Salem
The series focuses on increasing employee and overall organizational performance by providing participants the tools to hire right, communicate strategy, develop engagement programs and processes and create accountability.
"I hear executive teams talking all the time about conversion rates, retention rates, margins and revenues," said Wanda Ladd, President of Ladd HR Strategy, "What I don't hear them discussing is their employees and the impact that they have on every single one of those measurements."
Companies that attend the series will receive administration and results of an employee engagement survey that include a full analysis report. The participants will use these survey results to create an actionable plan to increase engagement in their company by leveraging employee's discretionary effort. The P3 Series explains the link between employee engagement and business performance.
Each P3 seminar will be held beginning in April and concluding in June, at the following venues:
• Charlotte – The City Club
• Raleigh – The Cardinal Club
• Winston-
Interested organizations and individuals can visit, www.laddhrstrategy.com/
# # #
Ladd HR Strategy removes the barrier between Executives and employees, allowing everyone to focus and work towards a common goal. Companies that Wanda has supported have been recognized as some of the Best Places to Work at both a local and national level. She takes pride in her ability to see the big picture and fully utilize an organization'
Wanda Ladd, MBA, PHR, has more than 15 years of experience in the field of human resources. She earned her Bachelor of Science degree in Finance/Economics at Thomas College in Waterville, Maine, and her MBA in Leadership and HR Management at the University of Colorado. Wanda is PHR certified and has completed the Business of HR Certificate Program at the University of North Carolina at Chapel Hill. While she has held roles in manufacturing, pharmaceutical and the financial services industries, her current role is Consultant at Ladd HR Strategy.
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by Anna and David Kasabian
See how easy it is to make the most appetizing, delicious and satisfying food ever by including ingredients with umami, the fifth taste.
What is umami? It's another basic taste, like sweet, sour, salty, and bitter. But it's not an ordinary taste. Umami is that rich, savory, extra-satisfying taste of mushrooms, steak, cheese, oysters, and red wine—just a few of the many foods loaded with umami. Umami is a quick and easy way to boost flavor dramatically by waking up taste buds you never knew you had. Science only recently proved its existence, and the world of food and cooking is catching on fast.
In the last year, reports on umami appeared in the New York Times, Saveur, Wine Spectator, Food and Wine, The New Yorker, and numerous other publications. And every day more chefs and home cooks are wowing guests, family and friends with fabulous-tasting umami-rich food. The Fifth Taste: Cooking with Umami is the first book ever to tell what umami really is, which foods have it (and which don't), and how to use umami every day for some of the best meals you've ever had.
Over 50 delectable umami recipes, for every occasion and for every level of cooking skill, such as:
Spicy Chipotle Pork Tacos with Sun-Dried Tomato Salsa from Rick Bayless
Sea Scallops with Mashed Potatoes and Red Onion Confit from Daniel Boulud
Cornish Game Hens Braised in a Pot with Summer Vegetables from Bradley Ogden
My Father's Famous Shrimp Hors d'Oeuvres from Lydia Shire
Lamb Shanks with Tomatoes from Christopher Kimball
Spicy Sour Botan Shrimp from Nobu Matsuhisa
Plus more everyday umami recipes, including:
Maxed-Out Meatloaf
Ragumami Tomato Two Meat Pasta Sauce
Asparagus Frittata
Coq au Vin Nouveau
Please-Pass-the-Umami Toasts
Vegetarian Muffaletta Roll-Ups
About the Author
Anna and David Kasabian are a husband-and-wife team who specialize in all things culinary. The author of nine books, Anna Kasabian has written for Country Living, Cook's Illustrated, Yankee Magazine, Coastal Living, and the Boston Globe. An honors graduate of the Culinary Institute of America, David Kasabian is a professional chef, food writer, and food photographer.
The Fifth Taste: Cooking with Umami
by Anna and David Kasabian
Hardcover; $27.50; CAN $39.95
Information provided by the publisher.
This page created February 2006
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Sal uses a tape diagram to decompose 7/9. Created by Sal Khan.
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Could You Pass 8th Grades Math
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Coach Romeo Crennel had little problem calling what wide receiver Braylon Edwards is enduring currently a slump. He's more concerned, however, with getting Edwards' problems corrected. Right now the wideout has five receptions for 46 yards. Gee, think those fantasy football wonks who have him on their rosters are a bit miffed? You betcha.
It's always troubling when a player goes through times like he is going through, when he is dropping balls that we need him to catch. We are trying to do everything we can to help get him out of his slump. A lot of times as a receiver, focus on the ball is one of the things. We have got numbers on the ball and we've got colors on the ball to try to improve his focus so he can relax and make some of those plays that we saw him make last year.
I think that this team is a better offensive team when we can have balance, when we can run the ball and throw play-action passes and drop back and throw the ball. Once a team becomes one-dimensional, then the defense can load up on it. Our ability to be balanced helps the offense. As the game progresses and things happen, you adjust and adapt to what you feel at that time and you go with it, Crennel said.


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The largest country in South America, Brazil is home the Amazon rainforest, bustling cities, Amerindian tribes and a rich colonial heritage. You can discover the diverse wildlife of the jungle and wetlands, spotting alligators, monkeys and parrots as you go. In the cities, try the street food, wander into ornate churches and soar up to the statue of Christ the Redeemer in Rio. Time it right and you can even join in with the carnival, where we can arrange for you to samba the night away in full carnival garb at the world's biggest fiesta.
Can't find it? Don't worry. Just because it's not here, doesn't mean we can't do it.
Call us on +44 207 426 9888 or +1 646 558 3644 or tell us what you're looking for here.
We'll make it happen.


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4604 South Union Street
Des Moines, Iowa, 50315
Commute to Downtown Des Moines
Most errands require a car.
Mostly flat, minimal bike lanes.
About your score
4604 South Union Street has a Walk Score of 25 out of 100. This location is a Car-Dependent neighborhood so most errands require a car.
This location is in Des Moines. Nearby parks include South Town Park, Sayers Park and Jordan Park.
Explore how far you can travel by car, bus, bike and foot from 4604 South Union Street.
View all Des Moines apartments on a map.
Popular apartment searches include single family, pool and fitness.
This location is in the city of Des Moines, IA. Des Moines has an average Walk Score of 44 and has 203,433 residents.


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The National Weather Service has issued a hazardous weather outlook for Oldham County and several counties in south central Indiana and central Kentucky.
This afternoon and tonight, gusty southwesterly winds up to 35 mph will occur again as another low-pressure system moves into the southern great lakes region.
Along with the gusty winds, thunderstorm chances will increase by late afternoon across southern Indiana and into central Kentucky and the blue grass through the evening. The main threats with any severe thunderstorms will be damaging winds.
Oldham Chamber & Economic Development has announced a business plan contest to encourage the creation, acceleration and expansion of businesses in the county.
The winner will receive a grant of up to $25,000 and a package of legal, marketing and accounting services that will help them launch or expand their venture in Oldham County.
LOUISVILLE --- Two times with under four minutes to play, North Oldham senior quarterback Cameron Renaud was intercepted. A fumble and a turnover on downs gave the Mustangs another chance, but the third time would not be the charm.
Renaud's third interception of the fourth quarter, with 59.3 seconds to play, sealed a 28-19 win for Western in the second round of the Class 4A state playoffs Friday night.
On a chilly Thursday night in late October around dusk, "Final Countdown," blares from speakers hooked up to a maroon Honda Odyssey mini-van.
The van, parked in the middle of a grassy area at Briar Hill Park gives the Falcons and Jaguars, two Oldham County Youth Football League teams, background music to amp up their practice.
Little black barcodes dot the Goshen Elementary library, where they're taped to shelves, doors, desks and even book spines.
To the naked eye they just look like, well, barcodes. But scanned with a smart phone, the barcodes bring up text, videos and other information.
They're quick response codes — barcodes that can hold data for 4,300 alpha-numeric characters in one small square.
The office manager of Centerfield Elementary School is charged with stealing a drug similar to Ritalin from a student.
Shelly Marie Settle, 43, of La Grange, is charged with narcotics theft and endangering the welfare of a minor. According to police, Settle allegedly removed 10 dexmthylphenidate pills from a student's prescription bottle and replaced the pills with baby aspirin on Monday afternoon.
Dexmthylphenidate, like Ritalin, is a Schedule II narcotic commonly prescribed for children and adults with attention deficit hyperactivity disorder.
I distinctly remember that moment, 12 years ago, when I plunked my final diaper purchase onto the conveyor belt at Wal-Mart.
My 2-year-old daughter was potty-trained, and I had decided that after she finished one more pack of diapers, I would let her wear undies.
I etched the moment into my mind because I knew it was a milestone in life.
There are many "last times" that go unnoticed when you are parenting, but because she was my last child, I did my best to pay attention and burn those moments into my memory.
Fast forward eight years.
Today's Americans have more to make their lives easier than any people who have ever lived. We live in the finest houses, wear the nicest clothing and eat the best food that any generation has ever known.
Yet, at the same time, so many of us take it all for granted instead of for gratitude.
Why do we take for granted the many blessings we have? Why do we fail to be more thankful?
Plans to build a Brownsboro elementary inched forward Nov. 9 when the district's local planning committee voted to make the project a top priority in the district facility plan.
Committee members voted 18-2 to raise the Brownsboro school priority from 2a to 1b, a change school officials say will make about $1.9 million available in state funding previously restricted because of the prioritization.
I'm awake before dawn, trying to get this article zipped up and submitted so I can focus on the tasks before me.
I'm thankful for the greeting of a crisp, clear, autumn morning, for this is the day we will bury my grandmother.
I was blessed to have been born with eight living grandparents. Over the years, I have watched as one by one they went on to their eternal reward.
Copyright © 2017
The Oldham Era is your source for local news, sports, events, and information in Oldham County and LaGrange, Kentucky, and the surrounding area.


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Susan Miller's Profile
I enjoying sewing almost as much as enjoying being a wife and mom. I have a degree in Family and Consumer Sciences. My love for sewing has been passed down from my mom and grandmothers. I have been sewing and creating for approximately 30 years. I believe all sewing should be professional looking and spotlight my own creative designs.
Due to health issues, my husband has spent the last 6 months learning this business and learning to run a commercial embroidery machine. As of Oct. 1. 2014, he will officially be taking over this business. Don't worry he has been doing 90% of the work since July. I will still be designing, but he will do the actual work. This business has been a lifesaver for our family because of my illness and we hope you will continue to support and help us grow.
- Female
- Born on July 7
- Joined October 18, 2009
- Susan Miller
- Ardmore, Alabama, United States


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From now on, you can play Deathmatch mode in Standard format; the rules and wins will be the same as in Extended format (to find out more about Standard format, click here). And, given the low number of players in Extended 25, we have decided to remove it from the list of formats available in Deathmatch mode. Finally, we have also decided to ban Ambre in Standard format and this will apply to all the different game modes. Happy gaming to you all!
Now then UR realized that they should have done it earlier!
With the removal of Extended 25 i now have no reason to continue to play this game anymore. You just removed the only T1 game mode that was keeping here. Every other game mode is T2 unless you like Elo if your in to that, which I'm not. It has way to many restrictions.
I, to this day still don't understand why you removed fights T1 to begain with
Ambre is giving T2 a bad name; she/it is the reason T2 is so hated, among other reasons I'm sure. I think the update does well to counter this. Though I wish they'd release more cards so clans other than Berzerk and Skeelz would be everywhere.
I mean, I'm not complaining, I use Junkz, and they rule. But no despite the fact that cards go obsolete anyway (quit whining about that you girls, think of the poor dusty Diego's and MC Decay's in your collection) I do think that a new low star format is what we need.
So now my only option is to play a bunch of 5 stars in Standard or a bunch of 5 stars in extended for deathmatches.
Really? I loathe type II (or whatever it's called now) and this, in turn, just made Deathmatches completely unplayable.
Any chance we can institute some sort of 25 for Deathmatch? I don't care if it's standard or extended or vintage or whatever.
Big mistake removing deathmatch t1.


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Cornish Hens And Rice
|Bacon slices
|Cornish game hens
|3 Pound (2 pieces, 1 1/2 pound each)
|Long grain rice
|1⁄2 Cup (8 tbs)
|1 Small, cut into thin wedges
|1 Clove (5 gm), minced
|Canned tomatoes
|7 1⁄2 Ounce, drained and cut up (1 can)
|Quartered mushrooms
|1⁄2 Cup (8 tbs) (fresh)
|Dry white wine
|1⁄4 Cup (4 tbs)
|Instant chicken bouillon granules
|1 Teaspoon
|1⁄4 Teaspoon
|Dried basil
|1⁄4 Teaspoon, crushed
|1 Dash, crushed
|Snipped parsley
|3 Tablespoon
In 10-inch skillet cook bacon till crisp.
Drain, reserving drippings.
Crumble bacon and set aside.
Tie legs of each cornish hen to tail; twist wing tips under back.
Brown cornish hens in the reserved drippings about 10 minutes.
Sprinkle with a little salt and pepper.
Remove hens from skillet.
Cook rice, onion wedges, and garlic in skillet drippings till rice is golden brown, stirring frequently.
Stir in tomatoes, fresh mushrooms, wine, bouillon granules, salt, basil, saffron, and 1 cup water.
Bring to boiling.
Return cornish hens to skillet.
Reduce heat; cover and simmer for 45 to 60 minutes or till poultry and rice are tender.
Transfer poultry to warm serving platter.
Stir parsley and crumbled bacon into rice; arrange rice mixture around hens.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 3284 Calories from Fat 1750
% Daily Value*
Total Fat 194 g298.9%
Saturated Fat 53.9 g269.4%
Trans Fat 0 g
Cholesterol 1378 mg459.3%
Sodium 2860.1 mg119.2%
Total Carbohydrates 110 g36.7%
Dietary Fiber 8.7 g34.9%
Sugars 7 g
Protein 249 g497.3%
Vitamin A 137.4% Vitamin C 164.9%
Calcium 36.4% Iron 101.2%
*Based on a 2000 Calorie diet


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Trial lawyers are hoping to turn California's endlessly abused and abusive s. 17200 "unfair competition" law (Oct. 26, etc.) to rich new account by using it to sue pharmaceutical companies over a variety of marketing practices that the U.S. Congress and Food and Drug Administration have not seen fit to ban. The Ralph Nader operation is helping out, while the litigation effort is being handled by Seattle trial lawyer and tobacco-caper veteran Steve Berman of Hagens & Berman (see Sept. 9-10, 2002 and links from there). (Bernadette Tansey, "Citizens use law to pursue drug firms", San Francisco Chronicle, Nov. 23; plaintiff's site ("Prescription Access Litigation"). Update: see Point of Law, Nov. 8, 2004.
4 Comments
This is your AG on drugs
Via Michael DeBow, guest-posting at Overlawyered: Vermont Attorney General William Sorrell, incoming president of the National Association of Attorneys General (NAAG), says he plans to lead the organization in a campaign against high pharmaceutical pri…
Trial lawyers & AFL-CIO, together
A coalition of organizations calling itself the Prescription Access Litigation Project files lawsuits against the pharmaceutical industry over its pricing of drugs (see Overlawyered, Nov. 24, 2003); it's represented by big-gun Seattle litigator Steve B…
Apple sued over iPod nano scratches
Class-action lawyers including Seattle's Hagens Berman (Feb. 16, Mar. 6 and Mar. 29, 2004; Nov. 24, 2003; Sept. 9-10, 2002, etc.) sued Apple last week in the name of buyers of the popular iPod, claiming…
Steve Berman sues Apple over iPods
Specifically, Seattle attorney Steve Berman (Nov. 24, 2003 and links therein), on behalf of a Louisiana man, accuses Apple of selling a "defective" product because it can cause hearing loss if one turns up music…