text:
Posted on 28 February 2006
- 12:00
We are giving you the chance to attend this spectacular Gala Evening by purchasing a limited edition Grand Draw ticket. By doing this you will acquire an original work of art to value and exhibit, celebrating the art of football and the glory of Spurs!
With each Grand Draw ticket you will also receive four places to the Gala Evening with live entertainment, a Q & A session with Spurs players and the Grand Draw itself making this an ideal opportunity to entertain friends or colleagues.
'Canvassing Spurs' Grand Draw tickets are priced at £1000 each and can be purchased by calling the ticket hotline now on 0208 885 1517 or by filling in the ticket application form found at http://www.kithandkids.org.uk/html/spurstickets.html .
Please join Tottenham Hotspur Football Club in supporting this exclusive fundraising event. All proceeds will go directly to their nominated charity Kith & Kids' life changing work with children and young people with disabilities and their families. We are looking to you to help us make a real difference to our community.
For further information please do not hesitate to contact Danielle Taylor, Events Co-ordinator at Kith & Kids on 020 8885 1517 or email firstname.lastname@example.com
28 October 2016
After being in high demand 12 months ago, the Club has once again produced a joint branded Tottenham Hotspur and Royal British Legion limited edition Poppy pin badge as we enter this period of Remembrance. And once again, it's selling fast!
5 October 2016
Graham Roberts played a huge role in our famous UEFA cup win of 1984 - and who better than the man himself to talk you through that glory night of glory nights on a Legend Tour?
26 August 2016
To assist our fans at the beginning of the new season we have launched an updated interactive map to illustrate best access routes into the stadium following the removal of sections of the North and East stands, the closure of Paxton Road to general access and the changes to the West Stand Car Park during the close season.
View mobile site
© Tottenham Hotspur Ltd 2016. All rights reserved.
All photography copyright Getty Images (unless otherwise stated)


text:
This proposal requests funds for continuation of a training program in fundamental chemosensory research at Florida State University (FSU). Four positions at the predoctoral level and two positions at the postdoctoral level are requested. The FSU Neuroscience Program, within which this Chemosensory Training Program operates, has a long history of high quality training and research in sensory systems, especially the chemosensory systems. The training program at FSU is firmly focused on the search for fundamental scientific knowledge, on which all applied and clinical understanding must be based. It is characterized by a diversity of research perspectives among the associated faculty and a diversity of research methodologies even within a single investigator's laboratory. Thus, the program affords pre- and post-doctoral trainees with unusual opportunities to explore and master many research approaches to important questions about chemosensory function. And to do so under the guidance of well-respected faculty used to productive collaborations. The research approaches represented in the Program include electrophysiological, molecular, anatomical, and quantitative behavioral analysis. The research support facilities are also exceptional;for example, molecular biological, electronics, computer, electron/ confocal microscopy and photography facilities, with professional staff, are all available to program members and trainees. A highly distinguished new faculty member has joined the training program since the last competitive renewal and almost all program faculties now have new laboratory space in new buildings. The notable features of this program include its distinguished history and excellent faculty, its focus on basis mechanisms studied in depth and breadth, and the outstanding technical facilities available. Trainees have an opportunity to acquire the perspective that is necessary for success in pushing out the boundaries of knowledge, and advice and assistance in obtaining the skills necessary for a career in externally funded productive research.
The training program at FSU is focused on the search for fundamental scientific knowledge, on which all applied and clinical understanding must be based. The program affords pre- and post-doctoral trainees with unusual opportunities to explore and master many research approaches to important questions about taste and smell function, whose loss involves devastating loss of quality of life, and whose central brain circuits are important in eating disorders, obesity, diabetes and hypertension;and perhaps other neurological disorders.
|Schier, Lindsey A; Hashimoto, Koji; Bales, Michelle B et al. (2014) High-resolution lesion-mapping strategy links a hot spot in rat insular cortex with impaired expression of taste aversion learning. Proc Natl Acad Sci U S A 111:1162-7
|Corthell, J T; Olcese, J; Trombley, P Q (2014) Melatonin in the mammalian olfactory bulb. Neuroscience 261:74-84
|Torregrossa, Ann-Marie; Nikonova, Larissa; Bales, Michelle B et al. (2014) Induction of salivary proteins modifies measures of both orosensory and postingestive feedback during exposure to a tannic acid diet. PLoS One 9:e105232
|Corthell, J T; Stathopoulos, A M; Watson, C C et al. (2013) Olfactory bulb monoamine concentrations vary with time of day. Neuroscience 247:234-41
|Tucker, Kristal; Cho, Sukhee; Thiebaud, Nicolas et al. (2013) Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel. J Physiol 591:2541-61
|Loney, Gregory C; Torregrossa, Ann-Marie; Carballo, Chris et al. (2012) Preference for sucralose predicts behavioral responses to sweet and bittersweet tastants. Chem Senses 37:445-53
|Mast, Thomas Gerald; Fadool, Debra Ann (2012) Mature and precursor brain-derived neurotrophic factor have individual roles in the mouse olfactory bulb. PLoS One 7:e31978
|Spencer, Corinne M; Eckel, Lisa A; Nardos, Rahel et al. (2012) Area postrema lesions attenuate LiCl-induced c-Fos expression correlated with conditioned taste aversion learning. Physiol Behav 105:151-60
|Rivera, Heidi M; Santollo, Jessica; Nikonova, Larissa V et al. (2012) Estradiol increases the anorexia associated with increased 5-HT(2C) receptor activation in ovariectomized rats. Physiol Behav 105:188-94
|Fadool, Debra Ann; Tucker, Kristal; Pedarzani, Paola (2011) Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1.3 ion channel. PLoS One 6:e24921
Showing the most recent 10 out of 35 publications

subset: commoncrawl


text:
by Duncan Larkin, Published Jul. 19, 2013, Updated Jul. 19, 2013 at 10:14 AM UTC
A 41-year-old mother of two ran a marathon every day for a year.
by Duncan Larkin, Published Nov. 11, 2011, Updated Sep. 12, 2012 at 12:55 PM UTC
She has had the illness for 38 years.
Start your FREE subscription to Competitor Digital today!
Get our monthly digital magazine, weekly running content & exclusive offers delivered to your inbox.
© 2014 Competitor Group Inc. All Rights Reserved


text:
Perhaps there is darkness in a sunrise, or bright sunlight in a moonless night, perhaps one only knows this when one has been burnt by the rays of a full moon as you lay naked, bathing in your dreams of an endless utopia.
These are the realities that we are able to create, that are forced upon our person by an increscent mind that is programmed to survive no matter how dark the existence that a new sunrise brings or the relief of purpose shown as a bright ray bathing you from our lunar in a dark night sky.
So what of this, is it that the disappointment of our created reality is so vast so vacuumed and consuming of light that we have had to contradict the physicality of science, that for sanity we have created an insane secret existence external to the sheets of agreed reality?
It's all about expectation, about the reality of our chosen paths and the one that taunts late at night as you lie in a state of comatose so incessantly happy. Of course this is not always the case sometimes your dreams are to close to reality and we call them nightmares others call them visions.
Then as we shuffle through our awaking hours we miss the beauty, we refuse to recognise the greatness of our lives. We cannot, it is impossible to compete with our dream state, there where we are happiest, there were everything is to be had, our six hours of daily heaven.
But today I saw the sunrise. I gazed into the light and was blinded by its promise. It brought me back, back form the abyss that swallowed my life, my humour, my humanity and I realised that it is beautiful, that there is no need to be anywhere but here, right now truly warmed and astounded by the sun, by your smile and the beating of my cold heart
© Copyright 2017 Vapour. All rights reserved.
Status: Finished
Genre: Editorial and Opinion
I think the realization you talk about in this piece is one that we rarely come to in our lives, because it takes courage. It takes courage to just be, to not do, to sit and watch the sunrise, instead of hurrying off into a day of obligations that we mostly bring on ourselves, that are not real, because, I believe, we are afraid to be happy most of the time, afraid to just be, to just live, and so we go on with our lives, dreaming of a better one, because we're afraid to see that it might be right in front us. Why? Screwed up human psychology - that's how far I've come to answer the question.
I think know what your talking about. But I could be completely wrong. Now you have me thinking though, so weather I understood this piece or not...
Some days, I sit on the back porch when it rains, thinking; and I see that there are so many things that we do as human beings that make up our lives. Our world revolves around a ticking clock. Appointments, meetings, dates...and when it all comes down to it, none of it matters. It's just a distraction. A lie, an illusion. Your whole world could crash...but you'd still be breathing, living, moving on. And you'd find that things are still going to be okay. You're fine without what you had.
What kind of reality is that?
Great thought. Great writing. Gave me goosebumps!
I was struck by this for two reasons:
1 because it is so oppsite to how I feel
2 because I have often wondered if when we dream, that is reality and this now is the nightmare. How else do you explain waking up feeling something you think was just a dream ?
Isn't it strange how at times we are are so relieved to be awake Nurse. Seems we have the ability to imagine/dream quite aweful events.
Short Story / Humor
Short Story / Mystery and Crime
Short Story / Religion and Spirituality
Paste the link to picture in the entry below:
Paste the link to Youtube video in the following entry:
Cannot annotate a non-flat selection. Make sure your selection starts and ends within the same node.
An annotation cannot contain another annotation.
There was an error uploading your file.


text:
Aramark Executive Chef Louis Ferretti
Presenting Aramark's guide to your own summer celebrations. Aramark is one of the leading caterers to sports events (like last year's Olympics), conventions and other celebrations. From pre-planning to execution, these world class recipes are sure to foster a culinary "gold-medal" for the party hosts. So, grab a fork and let the celebrations begin!
Preheat the oven to 350 degrees. Remove all shells from crab meat. Beat the cream cheese in a mixer bowl until smooth, scraping the bowl occasionally. Stir in the milk, crab meat, onion, horseradish, Worcestershire sauce and hot pepper sauce. Spread the mixture in a 9-inch round baking dish.
Bake for 20 minutes or until hot and bubbly. Sprinkle with the almonds and paprika. Serve with fresh vegetables and assorted party crackers.
Serves twenty-four.
For a variety in dippers, use mini carrots, mini zucchini and pattypan squash.
For the chicken, soak twenty-four 6-inch wooden skewers in water for 30 minutes or longer. Rinse the chicken and pat dry; cut into 1/2 x 1-inch strips.
Process the soy sauce, cashews, cilantro, sesame seed oil, salt, chili powder and cumin in a blender until the consistency of a paste. Rub the chicken with the paste to coat; place in a shallow dish. Marinate the chicken in the refrigerator for 2 hours or longer.
Thread the chicken on the skewers. Place on a baking sheet. Broil for 4 minutes per side or until the juices run clear. Chill in the refrigerator.
For the sauce, bring the sugar, white vinegar, water and red pepper flakes to a boil in a saucepan. Boil until the sugar dissolves, stirring constantly. Remove from heat. Stir in the carrot.
Arrange the chicken on a serving platter. Serve with the dipping sauce.
Makes twenty-four appetizers.
Provided by Aramark from:
Entertaining with The Home-Field Advantage
Designed and Produced by Favorite Recipes Press
Food Photography by Mike Rutherford
Aramark Corporation
Released 1996
Reprinted with permission.
This page originally published as a FoodDay article in 1997.
Copyright © 2007, Forkmedia LLC. All rights reserved.
This page modified January 2007
The FoodWine
Main Page
Kate's Global Kitchen
Kate's Books
Cookbook Profiles
Global Destinations
Holiday & Party Recipes
I Love Desserts
On Wine
Caffeine and You
Cooking with Kids
New Green Basics
Conversions, Charts
& Substitutions
About FoodWine
Contact Info
Privacy Statement
Anatolia: Turkish Recipes
Bar Tartine
The Beer Bible
Beetlebung Farm Cookbook
Bird in Hand (Chicken)
Bitter: Flavor
Bob's Joke Burgers
Cooking Light
Darjeeling Tea
Dinner at Home
Everyday Baker
Fast Food (Andrew Weil)
Flavor Flours
Food 52 Genius
The Food Lab
Garden Recipes
Grandmas' Recipes
Hartwood: Yucatán
Humane Butchering
Heritage Southern Recipes
Jemima Code African Recipes
Kitchn Cookbook
Liquid Intelligence
Near & Far World Recipes
NOPI Restaurant Cookbook
Oxford Companion to Wine
Phoenix Claws: Chinese
Picnic: Recipes
Soda Politics
Southern Recipes
The Third Plate
V Is for Vegetables
Vegetarian India
What Katie Ate
The Whole 30
Whole Food Kitchen
Yucatán Recipes
Zahav Israeli Cooking
Copyright © 1994-2016,
Forkmedia LLC


text:
Skip to comments.Is Free Republic becoming increasingly hostile towards Social Conservatives?
Posted on 02/07/2002 8:02:41 AM PST by watsonfellow
In the past few months I have noticed that the posters on Free Republic have become more and more hostile towards social conservatism.
And I do not mean indifference (less pro life threads etc) but an outright hostility at pro life and other social conservative causes.
Am I alone in thinking this?
In particular, notice the responses to the thread concerning the recent request by social conservative groups to the FCC to reign in Fox's racey primetime programs.
I wonder if this is becoming only a haven for hedonists and libertarians, and if so, perhaps it would be better for social conservatives to find their own site.
Constitutionalism is not libertarianism. A constitutional government may LOOK like a Libertarian's dream, but ask any Libertarian and they will not want to stop there.
Same with hard-line social conservatives. On FR, your causes take a back seat to constitutional government.
Yes, that would be a splendid idea. Go find your own site, and best of luck to you.
Spot on comment.
This is just an aggressive site which is why I like it, on any thread on any subject you will get flame wars going, all you do is know your facts, stand your ground and beat the other side down.
Cheers Tony
Social conservatism is fine as long as it isn't dispensed from the barrel of a state-owned gun.
This is good social conservatism:
"I don't watch those damned racy Fox shows. I won't let my kids watch them--I'm gonna get my like-minded friends together and we are going to contact the advertisers on those shows..."
This is bad social conservatism:
"No one should watch those damned racy Fox shows. I'm gonna contact the government so that the government can show up and shut them down by force if necessary"
Is that so hard?
I wonder if this is becoming only a haven for hedonists and libertarians, and if so, perhaps it would be better for social conservatives to find their own site.I don't mean to sound rude, but then what? Find our own state? Find our own country? At least we get to engage on this site.
I will say that I have gotten into it with a few people you would classify as "social conservatives" and I have not held back. Their interests seemed to be more in having a theocracy than a representative republic.
How very strange. The social conservatives want to use the power of nanny government to do the job THEY should be doing, which is to monitor and turn off objectionable television.
And a whiny thread like this does you no good either.
PS: some of us grew up with Buckley and Goldwater, before Falwell and Robertson, and we believe in the freedoms expressed in the declaration and the constitution. We believe government should not stand on the side of the road and point fingers at sinners. This is the traditional meaning of conservative before it became a refuge for some religious who want their idea of sin prohibited by the government.
If you want solace, flag cultural jihad and others of his ilk. They're still here in force.
If there has been such a trend, I attribute it to this: A lot of social conservatives left FR after the Buchanan Brigade debacle, while most of the socially liberal libertarians stayed around. That skewed the social conservative / social liberal ratio on a lot of threads.
Additionally, a lot of social conservatives on FR still tie their conservatism to causes like opposition to Bush and the Republican Party. That's obviously going to annoy most Freepers, who are largely Republicans and Bush supporters.
Actually, it was like that before the GWB nomination, with those supporting someone else really having to put up with a lot. And remember the Elian controversy...whew!!
I find that the controversy is healthy. When one's ideas are challenged, it forces one to think about his/her beliefs.
About the only things we seem to agree on totally is that Hillary is really, really disliked.
perhaps it would be better for social conservatives to find their own site.
Kitchen too hot-diddly-ot for you, Ned?
sinkspur? Is that really you? There is hope. Thank ye gods, there is hope.
The more rabid Libertarians who have been coming on strong lately, who seem to me to have more in common with those who were running the streets of New York last weekend, have caused me to solidify my conservative views and to soften my libertarian leanings.
And the rabid paleos who keep popping up like self-parodies have caused me to move away from whatever leanings I had in their direction.
They do make quite a mess of this place though.
I can't figure out why I need to be feeding people in jail though, if all they wanted to do was "lookit' some dirty pitchers".
...sorry, was that hostile?...
What's your definition? Did you even bother to read my post or is that just a 'canned reply' that you started this thread to use?
IMO, expect and want.
Just check the General Store portion of the catalog put out by our top-secret VRWC/Illuminati/Masonic/Templar organization. Prices are very inexpensive and come with a complimentary Møøse for our more discriminating clientele.
Remember, order now and receive your complimentary Møøse and fiscal year 2002 decoder ring absolutely free.
Der Elite Møøsenspåånkengruppen OberKømmååndø
Leave me alone!
But you will have to be able to defend your positions with real substantive points of argumentation, facts, beliefs with support.
People on here strongly believe in their point of view just like you do. I have seen no limitation of debate unless someone is attacking in a personal manner.
Many arguments that social conservatives have (not all) are based on strong emotion or faith...this is fine but to persuade someone or support your belief you
will have to temporarily leave you status as "mere believer" and go into a status of debater with support for you opinion. Of course you dont have to, but if you dont you arent going to build any hearing with people who disagree.
btw, I take views from all sides so attacking me as an anti-social conservative will be misplaced.
The first was a synopsis of the March with pictures and comments from those who attended. Maybe 75 hits to the thread.
The second was on the organizers of the march disallowing the Men From Glaad to march under a banner proclaiming how they got their rocks off. That thread had over 500 hits.
Yeah, I've noticed a change.
I applaud your intent, however Free Republic is hostile to anyone who doesn't use logic. (Sometimes it is hostile to those who do)I support social conservatism as a personal guidance system and educatory process. I do not support it as a national policy. I haven't seen much of any anti-pro-life posts here (although they could be here). I believe that there is a place for this debate within the policy structure.
That being said, I don't see television standards and policies based on social conservatism to do nothing but undermine your goals. The culture exsists because of the voices within society and not the laws that exsist. Speak your mind....lend your wisdom. Just keep the gvt. out of it.
BWAAAAAA HAHAHAHAAhahahahahahaah!!!
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
*This item is not regularly stocked or displayed in our Showroom, however it may be Special Ordered for you.
Item Availability is subject to Manufacturer Drop or Discontinuation. Please stop in or click Request More Info for additional details.
Why not show our Low Price?Rotmans sets our own prices on our TV & Electronics items, however some manufacturers have restrictions on how we may display the prices of their products. Since our price is frequently lower than their suggested retail price, they may not allow us to show you our Low Price until you place the item in your shopping cart. Adding this item to your cart does not require you to purchase it & you can easily remove it from your cart should you decide not to purchase.
Accommodate your TV with the stylish modern design of this TV stand and tall pier set. For storage, the TV stand features two side shelves and two center shelves for plenty of room for electronic devices. Two drawers with replicated oak drawer fronts and large matte black hardware provide contrasting style. Each tall pier bookcase includes a top light to highlight your accessories on the two adjustable glass shelves. The door with two shelves inside on each bookcase also provides functional storage to complete the wall unit.
The Harlinton Large TV Stand & 2 Tall Piers by Signature Design by Ashley from Rotmans. We proudly serve the Worcester, Boston, MA, Providence, RI, and New England area. Product availability may vary. Contact us for the most current availability on this product.
Rustic meets modern with this entertainment furniture collection. A warm gray vintage finish is complemented by replicated oak finish drawer/door fronts for a two-tone look. Several configurations are possible with the pieces available, so you can put together something ideal for your living room.
The Harlinton collection is a great option if you are looking for Contemporary furniture in the Worcester, Boston, MA, Providence, RI, and New England area.
These images are representative of this group as a whole and may differ from this item.
Browse other items in the Harlinton collection from Rotmans in the Worcester, Boston, MA, Providence, RI, and New England area.
This item has been tagged as: Wall Unit, Modular Pieces, TV Wall Unit, Living Room Wall Unit, Bedroom Wall Unit, Wall Storage Unit, Corner Wall Unit, Wall Shelving Unit, Media Wall Unit, Home Furnishings, Media Center, Entertainment Center, Entertainment Wall Units, TV Wall Unit, Television Wall Unit, Extended Entertainment Walls, Entertainment Unit, TV Furniture, Living Room Furniture, Entertainment Furniture, TV Armoire, Television Armoire, Media Storage, Bookcases, Wall Bookcase, Home Theater Furniture, Home Entertainment Furniture, Bookshelves, Home Theater Storage, Entertainment Armoires, Curios, Wall Curio, Curio Cabinets, Wall Curio Cabinets
Nothing on this page may be copied or reproduced without explicit permission.
Drag anItem Here
To start a new blank room plan, enter the desired room dimensions below and click Create Room.
To request a new password, enter your username or e-mail address and click submit. A new password will automatically be emailed to you.
If you are still having trouble logging on after receiving your new password, please email firstname.lastname@example.com


text:
Ads by TrafficFactory.biz
Need A Raise
Girl Massage Part 3
(7 min) sex rated 99%
Spa Treatment
(3 min) sex rated 97%
Lesbian sex in the spa
(18 min) sex rated 100%
Father and Daughter have sex in a spa room
(12 min) sex rated 100%
BDSM Vai comes back to Wiredpussy and SQUIRTS e...
(4 min) sex rated 100%
Voyeur Camera Spa Treatment Massage Toys
(6 min) sex rated 99%
SPA massage treatment
(5 min) sex rated 100%
Asian massage babe sucks on a cock with expertl...
(5 min) sex rated 98%
Diosa mostrando sus encantos en el Spa Parte II
(4 min) sex rated 99%
Caprice and Lola MyLuv - Passion at the Spa
(5 min) sex rated 96%
Massagecocks Twink Happy Massage
Swallow The Load #056 - Spa treatment
(1 min 30 sec) sex rated 100%
Ryo Kaede surprised at the spa with vibrators t...
(5 min) sex rated 97%
Gruelling Anal sex for Jenny Ulvari
(29 min) sex rated 99%
Sex Spa Scene
(2 min) sex rated 96%
Hot Teen Couple Shows Great Gagging Skills In Spa
(12 min) sex rated 99%
Monica gets nailed
(21 min) sex rated 98%
FantasyHD Sexy redhead's spa day turns erotic
(8 min) sex rated 100%
Happy Endings Day Spa - Vicky Vette & Lisa Daniels
(34 min) sex rated 100%
ENTER FREE: http://spa-massage.info --- http://...
(5 min) sex rated 99%
Cute skinny teen sucking and fucking for a facial
(11 min) sex rated 87%
FREE PORN : WWW.SPA-MASSAGE.INFO - http://love...
(13 min) sex rated 99%
Hana got with Bridget
All Girl Massage Megan Salinas oily Lesbian rub...
(10 min) sex rated 99%
Colombian Sex Spa. Lotbooty.com
(7 min) sex rated 100%
Busty chubby amateur girl sucks and fucks in a spa
(13 min) sex rated 96%
Feel The Beat(SPA) - IIDX21 SPADA New Secret So...
(2 min) sex rated 82%
Melissa Jacobs in Pleasure Spa
Hairy pussy naked in spa. 69-08. pinky.mx@hotma...
(1 min 38 sec) sex rated 81%
Swimming naked in spa. 70-03. firstname.lastname@example.com
(31 sec) sex rated 82%
RubATeen - Hairy Russian Teen Takes A Huge Cock
(8 min) sex rated 98%
Glamour blonde babe Deni Desire milking a cock ...
(6 min) sex rated 80%
Lily gets her twat rubbed along with sex from h...
(5 min) sex rated 88%
video-my-private-spa 720P 6
Candy is enjoying her time at the spa
Switch to old layout - Terms of service
- Content removal
- Upload Porn Videos - Tool to download flash videos
- Advertising


text:
Grades 2-5, Title 1 Approved! By Brian P. Cleary, illustrated by Brian Gable
Series: Words Are CATegorical ®
"Word-Nerd," Brian P. Cleary and highly-acclaimed illustrator, Brian Gable collaborate to clarify the concept of synonyms for young readers with playful, lively, and whimsical rhymes and humorous, comical, and amusing illustrations. For easy identification, synonyms are printed in color, and key words are illustrated on each page. This funny, best-selling series shows, not tells, each part of speech.
Awards • Book-of-the-Month Children's Club Selection • Junior Library Guild Selection Reviews Reviewed by: Booklist, Publishers Weekly, School Library Journal Review Excerpts: * "With a simple, silly rhyme and wild cartoon scenarios of animal characters in action, this picture book in the Words Are Categorical series shows and tells the meanings of synonyms. With the slapstick art enlivening things even more, this will be a fun read-aloud, and kids will certainily get the message that words are not boring." --Booklist * ". . . this excellent text goes a long way toward establishing the importance of synonyms." --School Library Journal * "Bright, colorful and appealing."--Think & Discover
Copyright © 2017 Teaching Resource Center


text:
The true story of the friendship—and rivalry—among the greatest American generals of World War II
Supreme Allied Commander Dwight D. Eisenhower, General George S. Patton, and General Omar N. Bradley engineered the Allied conquest that shattered Hitler's hold over Europe. But they also shared an intricate web of relationships going back decades. In the cauldron of World War II, they found their prewar friendships complicated by shifting allegiances, jealousy, insecurity, patriotism, and ambition.
Meticulously researched and vividly written, Jonathan W. Jordan's book recounts the battle for Europe through the eyes of these three legendary generals. For the first time in such detail, the bonds between them are explored, and readers are treated to an insider's view of life at the summit of raw, violent power. Throughout three years of hard, bloody warfare, Eisenhower, the Alliance's great diplomat, sought victory in the fighting qualities and tactical genius of his most trusted subordinates, Bradley and Patton. They, in turn, owed their careers to Eisenhower. Yet their friendship would be put to the ultimate test as life-and-death decisions were thrust upon them, and honor and duty conflicted with personal loyalty.
Brothers, Rivals, Victors is drawn from the candid accounts of its main characters and strips away much of the public image of "Ike" (Eisenhower), the "GI's General" (Bradley), and "Old Blood and Guts" (Patton) to reveal the men behind the legend. Adding richness to this story are the words and observations of a supporting cast of generals, staff officers, secretaries, aides, politicians, and wives, brought together to produce a uniquely intimate account of a relationship that influenced a war. The story of how these three great strategists pulled together to wage the deadliest conflict in history, despite their differences and rivalries, is marvelously told in this eye-opening narrative that is sure to become a classic of military history.
©2011 Jonathan W. Jordan (P)2011 Blackstone Audio, Inc.
"A truly compelling narrative…A masterly, exciting study of character and tactics in World War II." (Kirkus Reviews)
German by birth - cosmopolitan by conviction. A CFO enjoying dynamic and multicultural Asia. Classic car and history buff and scuba diver.
"Great study of characters and deeds"
Although no major learnings for me in regards of the war and the events in the african and european theatre, it is a highly recommendable book which defines the characters of the three generals very clearly and entertainingly as well. It is a matter of personal preference but my respect for Patton - being the most complex character of the three - rose the most. Besides of his extraordinary accomplishments in warfare and leadership it was always a great amusement to hear what he had to say in his very special way of expressing his thoughts - not at least when it came to Montgomery. Patton was likely more accepted and respected by his war enemies than by his brothers in arms. I also liked the narrating - very good voice, reading style and sound set up.
"Insightful and Enlightening"
This is a terrific book. It does a superb job of tracking the efforts and relationships among Eisenhower, Patton and Bradley throughout WW II as well as covering the before and after. It also does a fine job of showing how their personalities, beliefs and positions affected their relationships. It is fair to all three of the major protagaonists. Even when they are at odds with one another, you understand where each of them is coming from. I knew virtually no military history before listening and found some of that a little hard to follow, but that did not impair my enjoyment or abilty to follow what the book is really telling us about these three intriguing military leaders. It is well written and well read.
"A great history lesson! I learned a lot."
It was great to hear about the European front of WW2 from the writing of some of our finest military leaders. You don't know how fragile the egos of these men really were until you hear it from their own writings. We tend to forget that as good a leaders they were, they were still human and human flaws and frailty.
The British finally being made to look like the disrespectful, glory hounds that they were. They always wanted to be in the position to receive the glory and tried to minimize the American involvement when if it wasn't for the Americans, Britain would have ceased to exist!
"Don't know if I can finish it"
This just isn't a very good book. I've read lots of interesting books on WWII and lots of interesting biographies. This isn't one of them.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


text:
Added On: • Views: 386 • Duration: 01:03
Categories: Train
Tags: innocent, girl, my, dick, On, train
Description: Sorry, there is no description for this flick
Our site has a zero-tolerance policy against illegal pornography.
All galleries and links are provided by 3rd parties. We have no control over the content of these pages.
We take no responsibility for the content on any website which we link to. Copyright 2014


text:
Product Code: APH30LTG
Manufacturer: Apart
Our Price £65.99INC
Available within 2-5 working days
The H30LT-G is a powerful industrial compression driver horn loudspeaker. An ideal solution to cover long and wide distances for your speech reproduction or alarm signals, both indoor and outdoor. Even with higher background noise your message will be heard loud and clear!
This H30LT-G is made out of high impact ABS and supplied with a stainless steel bracket to avoid corrosion. The shape of the horn guarantees a wide horizontal dispersion.
The loudspeaker is equipped with a high quality 100 volt transformer with several power tappings.
The standard color of the H30LT-G is grey. From 12 pieces on, the H30LT-G loudspeakers can be painted in any RAL color (REF: PAINTMP).
|285 mm
|207 mm
|283 mm
|Loudspeaker system
|compression driver
|Mounting system
|100V transformer power taps
|30 - 15 - 7,5 - 3,75 watts
|8 ohms
|Low impedance dynamic power
|45 watts
|SPL 1W/1m
|106 dB
|Max SPL 1m
|121 dB
|Frequency response
|350 - 9K Hz
|Main construction material
|ABS plastic
|IP rating
|Applicable low impedance
|Applicable in 100V
|Horizontal dispersion angle 1000 Hz
|Vertical dispersion angle 1000 Hz
|Net weight product (kg)
With years of experience supplying Businesses, Government Organisations, Charities, Schools, Colleges and Universities, we invite you to take advantage of our knowledge to help you make an informed choice, ensuring you are purchasing the best music products for your needs. With specialists in PA Systems, Pro Audio & Live Sound equipment on hand to answer calls and emails, you're in the best possible hands.
Contact us now to discuss your requirements or to request a quotation. Additional discounts may apply for educational establishments or size and value of order.
Purchase orders can be sent directly to email@example.com or apply for your cash or credit account here. Terms and conditions will apply.
© Copyright 2017 A.C. Entertainment Technologies Ltd. All Rights Reserved - E&OE


text:
Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
If you are reading this message, Please click this link to reload this page.(Do not use your browser's "Refresh" button). Please email us if you're running the latest version of your browser and you still see this message.
Newegg.com - Computer Parts, Laptops, Electronics, HDTVs, Digital Cameras and More!
Showing Results: Most Recent
This review is from: ASUS Transformer Pad TF300T Tegra 3 32GB 10.1" IPS Tablet - White
Pros: Freakin thing just works. Android rocks on it. Fast, clear, beautiful screen, great camera. Outstanding network functionality. I use this thing on multiple wifi ndtworks, from enterprise setups to coffee shops, to residential. It connects every time. I use it with my tethered iphone and bluetooth; connects everytime. I even use this thing to remote assist in a pinch or connect to my biz server via rdp. It works. Buy one, you'll love it.
Cons: Uhhhmmmm, could be cheaper. Doesn't mow my lawn.READ FULL REVIEW
This review is from: Rosewill RSV-S5 - 5-Bay 2.5" & 3.5" Hot-Swap Storage Encl. System - RAID 0 / 1 / 5 / 10 / 5 + Spare / Spanning / JBOD - 120mm Fan, Port Multiplier, Tray Design - Controller Card Bundle
Pros: - Nice looking box
- easy to access trays
- well ventilated
- low price
Cons: Documentation in the box and what little is on the Rosewill website is poor, bordering on worthless. The design of this enclosure is also very poor; where to begin:
1. the status indicator lights cannot be seen when the door is shut. Truly, this is a minor issue. If there's a problem with the drive, I'm probably gonna know it before I check the lights.
2- the status indicator lights \cannot be seen from an angle more than 5 degrees above horizontal level with the drives. Translation, if you put the box anywhere lower than line-of-sight with the drives, you cannot see the lights.
3- The trays are cheap. The latch is really unintutitive and isn't really a tension/release latch at all, only an awkward handle to pull the drive out with.
4-the installation routine installs a very outdated version of java and doesn't function correctly without THAT version. Reinstalls ignore/overwrite any other Java version.
5- The quality of the included card is so bad it's stunning.
Other Thoughts: Review the drivers and control panel downloads on the Rosewill site carefully. Do NOT assume that the installer with correctly recognize your OS - it won't. Update the firmware from the Sil website.
Rosewill ought to be ashamed of this product; it is poorly conceived, poorly designed, and misrepresents both capability and compatibility in it's description. I would not suggest that anyone who is concerned about their data use this product. Both the hardware and software are outdated and very poorly implemented. I would return it, but the cost and headache of doing so outweighs any satisfaction I might gain. I'll just add a REAL raid card to it and move on. Can't say I'm very keen to make another Rosewill purchase.
This review is from: SYMA S031 Gyro Metal Frame 3.5 CH RC Helicopter Jumbo Size
Pros: Looks awesome! It's FREAKIN' TWO FEET LONG! It is an impressive sight to behold and generates a tingling sensation in the brain when you look at it.
Cons: Well, I ASSUMED that this thing would fly. I mean, that is the intent of a RC aircraft, one would think. Sadly, it does not; most of the time it is unresponsive to the controller. At times, it just does nothing, stares at you with it's prettu led lights going back and forth, back and forth. At other times it teases you by starting up and lifting into the air as if it will fly!... then dropping out of the sky like a stone, usually assuming the previously described unresponsive state. Very sad, very disappointing. Still... it looks GREAT!
Other Thoughts: Unless you're looking for a magnificent conversation starter to place in your den or living room, move on.READ FULL REVIEW


text:
Articles from RotoWire's fantasy archives that mention Tony Wolters's name.
January 23, 2017
Collette Calls: Late-Round Bargains
Jason Collette looks at the most intriguing players ranked below 150 in RotoWire's latest 350, including Rajai Davis, whose stolen-base skills make him a late-round bargain.
September 25, 2016
NL FAAB Factor: Waiver Pickups of the Week
With October playoff baseball just around the corner, Jan Levine breaks down his National League free agents of the week one last time for the 2016 season.
June 12, 2016
Erik Siegrist checks out the available National League free agents while everyone waits for Super-2 callups and finds a strong group of veterans coming off the DL, including Diamondbacks outfielder David Peralta.
June 5, 2016
Jan Levine scours the NL waiver wire and wonders if Derek Norris can turn things around in another uniform as the Padres begin their fire sale.
May 21, 2016
Weekly Hitter Rankings: White Sox Set to Pop
Erik Siegrist breaks down his hitter rankings for the week, dominated by a trio of AL squads with eight and seven-game slates.
May 15, 2016
Jan Levine sifts through the available talent in the Senior Circuit and doesn't think you can overlook Marcell Ozuna any more, even in shallow formats.
May 8, 2016
Jan Levine highlights the NL's free agent options for the week, and notes that there could be a new closer in Cincinnati.
April 17, 2016
Jan Levine details the best free agent targets in the National League, and looks for value in an unsettled Braves outfield
April 3, 2016
Jan Levine looks over the winners of spring job battles for roster-worthy buys, and sees a lot of moving parts in Arizona due to A.J. Pollock's latest injury
March 25, 2016
Spring Training Job Battles: Countdown to Opening Day
Clay Link checks in on all the major positional battles from around Major League Baseball. Is Aaron Sanchez a lock to make the rotation?
March 3, 2016
Spring Training Job Battles: And We're Off
Clay Link previews all the major job battles from around the league. Can Drew Hutchison make amends for last year and earn a spot in the starting rotation?
January 22, 2014
Behind the Backstop: Scouting 101: The Tools of Ignorance
Catchers with elite defensive skills and the ability to provide steady offensive production are a rare breed. In his latest Scouting 101 installment, Tory Hernandez explains the difficulty of scouting the position and its importance.
August 6, 2013
House of Shlain: Organizational Top-10 Lists: AL
With Miguel Sano and Byron Buxton ascending in their system, the Twins may have the best collection of minor league talent in baseball. Nick Shlain takes a look around the American League and shares his top-10 from each organization.
May 8, 2013
Bernie On The Scene: A Look At Second Base Prospects
Delino DeShields Jr. has plenty of speed, but will he get on base enough to use it? Bernie Pleskoff takes a look at the future crop of options at the keystone.
October 19, 2012
Pleskoff's AFL Notebook: Under the Radar
The Rangers' Chris McGuiness is among the early surprises in the Arizona Fall League. RotoWire's Resident Scout Bernie Pleskoff takes a closer look.
July 25, 2012
Bernie On The Scene: Grading the Middle Infielders
An increasing number of middle infielders are showing power akin to Rangers second baseman Ian Kinsler. Bernie Pleskoff takes a closer look.
Advanced Search
All-Time Fantasy Baseball Team
Ask An Expert – Fantasy Baseball
Auction Values – Custom
Auction Values – Custom Tiers
Auction Values – Earned
Batting Orders
Cheat Sheets
Cheat Sheets – AL-Only
Cheat Sheets – NL-Only
Cheat Sheets – Foreign
Closer Situations
Daily Lineups
Depth Charts
Draft Kit
Draft Software
Draft Software (Mac)
Draft Strategy
Fantasy 101
Games by Position
How to Play Fantasy Baseball
Injuries – MLB
Injuries – AL Only
Injuries – NL Only
Injuries – By Team
Injuries – By Position
Lineup Card
Local Papers
MLB Box Scores
MLB Commissioner
MLB Lines
MLB Standings
MLB Team Pages
News – Latest
News – AL Only
News – NL Only
News – Closers
News – Foreign Leagues
News – Free Agents
News – Minor Leagues
News – Recap
News – Top 100 MLB
News – Top 400 Prospects
Projected Starters
Projections – Rest Of Season
Projections – Daily
Projections – Weekly
Projections – Changes
Prospects – By Team
Prospects – Top 200
Rankings – Custom
Rankings – ADP
Rankings – Custom Points
Rankings – Custom H2H Roto
Rankings – Custom H2H Points
Rankings – Expert Composite
Rankings + Outlooks
Rankings + Outlooks – Catchers
Rankings + Outlooks – First Base
Rankings + Outlooks – Second Base
Rankings + Outlooks – Shortstops
Rankings + Outlooks – Third Base
Rankings + Outlooks – Outfielders
Rankings + Outlooks – Starting Pitchers
Rankings + Outlooks – Relief Pitchers
Recent Debuts
Reliever Usage Report
Defensive Stats
Stats – Advanced
Stats – Batter v. Pitcher
Stats – Explanation
Stats – Second Half (Batters)
Stats – Second Half (Pitchers)
Stats – Spring Training
Stats – 3-Year Averages (Batters)
Stats – 3-Year Averages (Pitchers)
Team Previews
Weather Report for MLB Games
Fantasy Baseball Columns
120 Sports & RW Video
120 Sports DraftKings Advice
120 Sports FanDuel Advice
AL FAAB Factor
Collette Calls
DFS Baseball 101
DraftKings MLB
FanDuel MLB
Fantasy Baseball Injury Report
FantasyDraft MLB
Farm Futures
In Some Depth
Minor League Barometer
MLB Barometer
MLB Daily Games Strategy
Mound Musings
NL FAAB Factor
Pitching 3D
Regan's Rumblings
Short Hops Podcast
SXM Highlights
The Long Game
The Saber's Edge
The Wheelhouse
The Z Files
Toeing the Line
TYT Sports MLB Video
Umpire Analysis
Video Shorts
Weekly Hitter Rankings
Weekly Pitcher Rankings
Yahoo DFS Baseball


text:
More Videos...
Caprices chopped bug 1st run
Caprice took her chopped '68 bug around the block for the first time since the 2 yr re-do.
VW 1302 GTO mid mounted mitsubishi 6g72 twin turbo engine
The car is under construction;-)
Beetle Crisis episode 4 Part 1
Beetle Crisis
1958 beetle bagged!!
Bagged bug!


text:
- DesksAdjustable Height Standing Desk Selector ToolUPLIFT Desk VideosUPLIFT Desk Photo GalleryCustomer Photo GalleryMost Popular Stand Up DesksQuick Ship Standing DesksUPLIFT Solid Wood Adjustable Height DesksUPLIFT Stand Up Desk with Reclaimed Wood TopUPLIFT Eco or Laminate Height Adjustable DeskUPLIFT Space Saver Standing DeskUPLIFT Standing DesksUPLIFT Laminate Adjustable Height DesksL-Shaped and Large Corner Standing DesksUPLIFT Treadmill DesksUPLIFT ProUPLIFT Base Only Adjustable Height DesksUPLIFT Desk AccessoriesUPLIFT Eco Corner Sit-Stand Desk with L-Shaped TopShop other UPLIFT desks >>
- ChairsMesh ChairsBig and Tall Office ChairsPetite Office ChairsErgonomic Drafting Chairs and StoolsSit Stand SeatingHigh Back ChairsChairs with HeadrestsMid Back ChairsTask ChairsLeather ChairsExecutive ChairsKneeling ChairsIntensive Use ChairsUPLIFT Motion StoolShop all popular chairs >>
- Workstation AccessoriesUPLIFT Desk AccessoriesMonitor ArmsKeyboard TrayCPU Holder and Computer MountErgonomic KeyboardErgonomic MouseStorage and OrganizationErgonomic Foot RestsDesk Corner SleeveAnti-Fatigue Mats and Standing MatsUPLIFT Desk AccessoriesSee all UPLIFT accessories >>
- BrandsUPLIFT Standing DesksHumanscaleSteelcaseRaynor EurotechKnollBalt ProductsBodybilt ChairsergoCentric ChairsErgotechESI ErgonomicsEvoluentExtech InstrumentsFocal Upright FurnitureGoldtouchHealth ChairHOGGANergoThe Human SolutionInnovative Office ProductsISE ErgonomicsKinesis ErgonomicsMaylineMatias ProductsMark-10Neutral PostureNightingaleNOTRAX Anti-Fatigue Floor MattingOffice StarPosturiteUPLIFT DeskShop all brands >>
- Ergonomic Tools & GuidesErgonomic Tools & GuidesErgonomic Office Desk, Chair and Keyboard Height CalculatorAdjustable Height Standing Desk Selector ToolThe Human Solution Blog -- Tips for a Healthier OfficeErgonomic Chair Buying Guide: How to Select an Ergonomic Office ChairMonitor Arm Buying Guide: How to Select an Ergonomic Monitor ArmKeyboard Tray Buying Guide: How to Select a Keyboard TrayErgonomic desk, chair and keyboard height calculatorSee more ergonomic tools >>
- MoreChairsDesksTreadmill DesksKeyboard TrayMonitor ArmsErgonomic MouseErgonomic KeyboardErgonomic Foot RestsTask LightWorkstation AccessoriesMac Compatible Ergonomic ProductsPlantronics HeadsetsLaptop ErgonomicsBudget ErgonomicsHumanscale ViewPoint Technology Wall StationsHealthcare Monitor ArmsHealthcare Chairs and StoolsHealthcare Keyboard TraysHealthcare Anti-Fatigue MatsUPLIFT Standing DesksAssessment ToolsIndustrial Equipment ToolAnti-Fatigue Mats and Standing MatsHand Trucks and DolliesErgonomic Drafting Chairs and StoolsErgonomic SoftwareMaterial Handling EquipmentDesk Edge ProtectorErgonomic StoolsAdjustable TableEntrance and Carpet MatsErgoKitAnthropometric Testing EquipmentForce GaugeHand DynamometerPinch DynamometerSensory Evaluation ToolThermo-hygrometerSound Level MeterLight MeterGoniometer and InclinometerEMGStopwatchTorque Testers and Torque GaugesScaleErgonomic SoftwarePocket Ergo®Ergonomic Consulting & Assessment ServicesVibration Meters
- Deals
Steelcase Turnstone Alight End Table TS34410TX
The Steelcase Turnstone Alight End Table instantly provides a warm, upscale quality to any workspace or reception area. Featuring a sleek design, a glass top, and a choice of three different wood veneer finishes, Alight End Tables blend the classic with the contemporary while providing a practical place to display anything from collectibles to reading material. Pair the Alight End Table with the Turnstone Alight Coffee Table for a uniform, elegant workspace.Read More...
|Choose Options Below
|click on for more info
|- required
Veneer color
The Steelcase Turnstone Alight End Table TS34410TX is available in the following colors:
- Details
- Accessories
Add a warm "at home" quality to any workplace or reception area with the Steelcase Turnstone Alight End Table - TS34410TX, part of the Alight line from Turnstone. This stylish Turnstone Alight End table is quick and easy to assemble, and it features a strong wood veneer base and glass top that will remain sturdy over time.
Features -
Steelcase Turnstone Alight End Table - TS34410TX
- Choose from three wood veneer colors: Natural cherry, clear maple or dark walnut
- Glass top is sturdy and will hold up to frequent use
- Quick to assemble and easy to maintain
Steelcase Turnstone Alight End Table - TS34410TX Specifications
|27 lbs
|Wood, veneer, glass
|Covered by Steelcase limited warranty
Download more information
Professor Ergo's Thoughts:
The Steelcase Turnstone Alight End Table blends modern design with classic style. It's sure to provide a sophisticated accent to any office, and it looks especially sleek in a reception area.


text:
Saturday, November 2, 2013 - 7:30pm – 9:30pm.
Boettcher Concert Hall 1000 14th St. Denver
Ticketed event
Call 303-623-7876
Call 303-623-7876
Passport to Paris Masterworks Series (Nov. 2)
This celebration of French music, art and life is the first in a partnership with the Denver Art Museum's Passport to Paris exhibition. The City of Light inspired many of the great composers, including Mozart, whose Symphony No. 31 opens this Parisian program. Colorado Symphony Principal Flutist Brook Ferguson takes an elegant solo turn on Debussy's Syrinx and Ibert's Concerto for Flute, while Principal Violist Basil Vendryes animates Berlioz's Harold in Italy.
Download the Colorado Symphony's November program here.
Concert is also offered on November 1 at 7:30 pm and November 3 at 2:30 pm.
For ticket prices or to purchase tickets, call the Colorado Symphony Box Office at 303-623-7876 or visit www.coloradosymphony.org.


text:
Best Easy Pesto Recipe
Are you tired of Fabio yet? I hope not – because I could watch his videos every day! They always consist of simple recipes, delicious looking food, and pure entertainment. Here is his famous, simple pesto recipe. Forget about all of those other fancy recipes you may find on the web – this one is the only one you need. I just made this for dinner and my husband went (pine) nuts. Watch and learn if you want to see him make it! See my breakdown of the recipe, below.
- 1 large bunch fresh basil leaves (approximately 2 cups)
- 1/2 cup pine nuts
- 1 cup olive oil
- 3 cloves garlic
- 3/4 cup Pecorino Romano grated cheese (many traditional pesto recipes use Parmesan, but Pecorino is freaking DELICIOUS. I substitute this for Parm almost all the time.)
- salt & pepper (about 1/2 tsp. each)
Directions: place everything except for the cheese in a food processor. Blend for just under a minute or so. Like Fabio says, you want your pesto to be "chunky."
Once it's well blended and the leaves are all broken down, add the cheese. Blend for just 7 – 10 seconds more. That's it!! You are officially a bad-ass-little-italian-pesto-making-machine. WASSAMATTAFOYOUUU?? Ahem.
Store this batch in a jar in your refrigerator for up to a week. or pop it in the freezer for future use.
Latest posts by Alessandra (see all)
- For 2017 - January 1, 2017
- Family-Friendly Vegetarian Recipe from What a Good Eater! Cookbook - December 13, 2016
- Stage Mom - December 4, 2016
Tags: Fabio Viviani, fresh recipes
Trackback from your site.
Comments (3)
Boban Alempijevic
Ooohhh, I am soo saving this one, I love pesto on fresh hot bred 🙂 Not to mention all kind of food recipes 🙂
ali mac
Boban!!! Me too. It is so great to hear from you 🙂 Glad you enjoyed the pesto recipe – it is so yummy!!!
The 5 Best & Easiest Herbs to Grow Indoors | TrulyCozy
[…] if temperatures are very warm – mist lightly if leaves begin wilting – Ideal recipe: Pesto […]


text:
Moms deserve to be spoiled on their special day, so ditch the burnt toast and soggy cereal this year and whip up one of these yummy recipes. They're so easy, kids can help dad make the morning meal. (And don't forget to clean the kitchen for mom when you're done!)
Read Whole Story
These unfussy recipes -- for a crustless quiche, a dazzling fruit salad, an a.m.-appropriate cobbler and more -- take about as long to prep as it take...
Dads, help your children give mom the best homemade Mother's Day gift she could possibly ask for -- that's right, breakfast in bed. Here are some tips on how to ensure this operation is a success and not a disaster!
Let Mom sleep in on Sunday and treat her to a delicious homemade breakfast. Here are ten sweet and easy recipes the whole family will love.
Create a luxurious, leisurely morning for mom, where she can relax in bed for hours -- and come out feeling truly pampered.
Kids, are you taking notes? 3 breakfasts-in-bed and 3 celebratory dinners that mom's little helpers (or big ones) can tackle with pride.
Breakfast in...
Right now, at this very moment, I am having chocolate on a warm, toasted, sourdough baguette. It was my son's dream come true to get up in this morning and make chocolate for breakfast; I'm like a dream mom to even ask for such a thing.
Get top stories and blog posts emailed to me each day. Newsletters may offer personalized content or advertisements. Learn more.


text:
You have Adblock enabled. Adblock has been known to cause issues with site functionality. If you experience any difficulties, please try disabling Adblock. Close
Add to Favorite List:
Create a new folder:
Fucking the white boy
Recognize a pornstar in this video?
Help make pornstars easier to find on Tube8 by telling us who is in this video.
Thanks! The pornstar names will be added to this video when enough users submit the same names.
You must enter a pornstar name that already exists in our database.
- Category: Anal
- Views: 213,176
- Added: 6 years ago
- Description: A hot muscular black stud fucks a white bottom nice and deep.
- Tags: bareback, interracial, muscle, fuck
- Pornstars: Add Pornstar
- Favorite by: 387
- Featured: 6 years ago
- Report This Video
Video Comments
Top Video Comments
All Video Comments (15)
8 months ago
8 months ago
heiss geht mal auf die seite kohle oli , voll geil
- 0 people liked this -
5 years ago
5 years ago
Love him to fuck my wet man pussy and dump a hot load in it.
- 0 people liked this -
5 years ago
5 years ago
The bottom is cute, but that hot black dude and his hot cock could fuck me anytime, oh yea
- 0 people liked this -
6 years ago
6 years ago
Poor vid. No Cumshot. Hot top if he could keep it hard.
- 0 people liked this -
6 years ago
6 years ago
it's okay but the top is definitely wearing a condom. look closely.
- 0 people liked this -


text:
Invaluable cannot guarantee the accuracy of translations through Google Translate and disclaims any responsibility for inaccurate translations.
Show translation options
Lot 1081: Chinese clair de lune porcelain vase
Millea Bros "SELECT" (Day 1 of 3)
by Millea Bros. Ltd.
November 3, 2016
Boonton, NJ, USALive Auction
Looking for the realized and estimated price?
Description: Qing Dynasty, possibly Kangxi, empty underglaze blue double ring mark, 7.5"h x 4.75"dia.
Condition Report: Fair, restorations, in need of further restoration, glaze hairline to body, minor flakes to footrim
Browse more items


text:
Cardiovascular disease is one of the leading causes of death in the US, and the inability to repair damaged muscle is a major obstacle in treating heart disease. Currently, there are no definitive methods to improve heart function after a heart attack, and a common result is permanent muscle loss. While a significant amount of research has focused on the ability to expand or generate cardiomyocytes for replacement of the damaged tissue, less focus has been placed on controlling the detrimental effects of fibrosis and enhancing the beneficial effects of angiogenesis. Additional information on the epicardium, or outer layer of the heart, may provide insights into these processes. Studies have demonstrated that epicardial cells differentiate into cardiomyocytes, vascular smooth muscle cells, endothelial cells, and fibroblasts, and an in depth knowledge of the mechanisms that cause these cell populations to form in the embryonic heart will be essential for programming the adult epicardium to generate these cell types after heart injury. Platelet derived growth factor (PDGF) signaling pathways are essential for normal epicardial development, and the main goal of this proposal is to discover how PDGFs direct epicardial cell development and differentiation. This goal will be accomplished using epicardial-specific loss-of-function alleles of the PDGF receptors in the mouse.
The specific aims of this proposal are: 1) To determine the mechanism of PDGF receptor action in the initial development of the epicardium;2) To elucidate the requirement for PDGFR? in coronary vascular smooth muscle cells and cardiac fibroblasts;and 3) To determine if PDGFR? signaling is required for fibroblast development and function within the heart. Understanding the mechanisms of PDGF receptor function in the epicardium and epicardial derived cells will provide important insights into the signaling mechanisms governing epicardial cell biology and potentially reveal signaling pathways that could be manipulated to control fibrosis and direct angiogenesis after cardiac injury.
Cardiac fibrosis and impaired coronary artery function are two major features of heart disease, but few drugs or therapies have been identified that act upon the cells responsible for these problems. The goal of this research is to identify signals that can alter the formation and function of these cell types. Manipulation of these signals could improve the outcomes of cardiac injury. The success of these studies will provide information to advance the treatments used in repairing damaged hearts and reducing fibrosis.
|Zhao, Chen; Guo, Hua; Li, Jingjing et al. (2014) Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 141:281-95
|Moore-Morris, Thomas; Tallquist, Michelle D; Evans, Sylvia M (2014) Sorting out where fibroblasts come from. Circ Res 115:602-4
|Wood, Michelle A; Acharya, Asha; Finco, Isabella et al. (2013) Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus. Development 140:4522-32
|Neubauer, Bjoern; Machura, Katharina; Rupp, Verena et al. (2013) Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-* signaling. Physiol Rep 1:e00132
|Baek, Seung Tae; Tallquist, Michelle D (2012) Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation. Development 139:2040-9
|Chhabra, Akanksha; Lechner, Andrew J; Ueno, Masaya et al. (2012) Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell 22:651-9
|Smith, Christopher L; Baek, Seung Tae; Sung, Caroline Y et al. (2011) Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ Res 108:e15-26
|Caglayan, Evren; Vantler, Marius; Leppänen, Olli et al. (2011) Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase C? 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo. J Am Coll Cardiol 57:2527-38
|Wu, Mingfu; Smith, Christopher L; Hall, James A et al. (2010) Epicardial spindle orientation controls cell entry into the myocardium. Dev Cell 19:114-25
|Zhou, Li; Takayama, Yoshiharu; Boucher, Philippe et al. (2009) LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One 4:e6922
Showing the most recent 10 out of 13 publications


text:
Meat From Australia - Australiaprice: contact company for price
Meat From Australia
Please see our contact information below
Company Contact:
- Posted By: Rangelands Produce Australia Pty LTd
- Phone: 61894701781
- Address: PO Box 8055 Angelo St., South Perth, Australia
- Email:
Published date: September 7, 2012 -
- Business Description: involved in international trade import export of goods, products, and services
Related listings
Beef Feet FrozenMeat / Poultry - Beef - Antonivskii Meatplant LTD - Ukraine - August 8, 2016 - 0.55 Dollar US$
Beef feet deep freezing.We are from Ukraine and we have our own factory for the processing of beef and pork products and by-products production. we can provide any volumes in normal time. At the moment we are interested in cooperation with companies ...
Frozen Duck Paws SuppliersMeat / Poultry - Beef - SEARA ALIMENTOS S.A - Brazil - June 18, 2016 - 900.00 Dollar US$
Frozen Duck Feet & frozen Duck Paws Features: Duck Feet - Washed and clean. - yellow skin Off. - No feathers. - No bad smell. - No blood. - No bruises. - No black pads. - No traces of carved deep wounds. - No ammonia burns. - Broken bones: under ...
Pork Meat Cuts And CarcassesMeat / Poultry - Beef - CANARIAS IMPOTACION SL - Spain - May 26, 2016 - contact company for price
Our company has import and export relations with many countries around the world as EU market, India, Asian markets, and world wide . Port Feet, Port Ear, Pork Legs, Pork Ham , Pork Hock, Pork Head, Pork Offals, Pork Trimmings ETC. Pork Collar Bonele...
Safe Trade Tips
- Ask for business references and check them
- Use a payment method that offers better protection for all such as Letters of credit and verified professional escrow services. Avoid payments in advance such as money transfers
- Verify their business via their local Chamber of Commerce
- Search the internet using their website address, their business name, their phone and fax numbers, and their email addresses to see if you can find any feedback about them.
- Get to know more about scams to avoid: Internet Crime Complaint Center - International Financial Scams
- This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"


text:
Proudly serving our Veterans for over 20 years, our community is comprised of diverse people from all over the country who want a quiet, small town atmosphere. Westminster Village has a swimming pool, walking trail, gymnasium, a bowling alley on site and many more amenities, allowing our residents to pursue an active, fulfilling lifestyle without leaving our campus! Dedicated to family, fun and affordability, Westminster Village of the Mid-South is an Arkansas retirement option you don't want to miss out on! Come see our spacious three and four bedroom residences, you'll be glad you did!
Celebrating our 20th anniversary.
With three bedroom residences starting at an affordable rate per month, Westminster Village of the Mid-South is the place you've been looking for! Rent includes:
• Landscaping
• Maintenance
• Security
Ready to learn more?
Ways you can donate to Westminster Village of the Mid-South
Shop through amazonsmile.com and choose Westminster Village of the Mid-South as your charity. 5% of your purchase goes to Westminster Village of the Mid-South for capital improvements.


text:
Reviewed By Rex H (PEARL CITY, HI) Reviewed for a 2008 Ford F-250 —1/11/2017 9:44 PM
they do whistle going down road and i ordered an addition set of supports in the middle,
Reviewed By James F (Kingwood, TX) Reviewed for a 2014 Ford F-150 —1/11/2017 10:56 AM
Received my Adarac model #70490 on time and install was quick and easy on my 2014 F150 Crew cab 5.5ft bed truck. Functions with my Undercover Flex three panel tonneau cover, if you reach in and unlatch the middle panel as well. Otherwise move the rear verticals an inch or two forward for panel clearance. The kit comes with three spacers per stake pocket. A bit confusing since all the online videos and photos in the instructions show two. Bought the rack to transport two 14ft kayaks. Great Value.
Reviewed By Judy S (Rawlings, MD) Reviewed for a 2015 Ford F-250 —12/30/2016 9:02 PM
I ordered the rack for my husband for Christmas. Was unsure what I was ordering and I used the chat option offered on the web site. It was extremely helpful ! Very happy overall with my experience on auto anything.
The jobsite is no place for a wimpy truck. Outfit your rig with these top-ten hardworking picks and roll up in a workhorse.
You drive a truck for a reason: versatility. Maximizing your truck bed takes just minutes and can be both simple and affordable. You've got the space - Want to make the most of it? Here's how.
Know before you buy! Read customer reviews about Truck Racks & Van Racks or ask our Product Experts.
Side-by-side comparison of four popular ladder rack types: over-bed racks, over-cab racks, side mount racks and van & shell racks.


text:
Let me pitch some ideas. You are a commissioning editor, looking desperately for a fresh angle on the old genres. You are also indifferent to recent mutterings that the medium has become obsessed with detectives and police series. After all, you know that the public loves crime drama, and the prospect of some mild tutting from the Independent Television Commission troubles you far less than the terrifying thought that your rivals might find next year's fashion first. So here are some suggestions.
First, what about John Thaw as a military policeman? Peculiarly unpopular figure, I know, but you could work with that, draw something Morse-like out of the contrast between the unyielding discipline of the uniform and the tender, troubled heart within. Terrific global locations, too, which will give you a Soldier, Soldier feel, and it's pretty topical, what with the murders in Cyprus and Private Lee Clegg. The stories virtually write themselves - what about a murder in Bosnia, which turns out to have been committed by a frustrated peacekeeper taking retaliation? What about a racketeering scam in Belfast, suddenly exposed by the peace process?
If you don't like that, how about a series based around industrial espionage? I am really excited about this, I have to tell you. We are smack in the middle of the Eighties hangover, worried about greed and ethics and the money culture. And the international marketplace is the Second World War by other means. What are the Germans up to, everyone asks, and when does the next big push come from the Japanese? You get everything: boardroom intrigue, cutting edge technology, commercial ethics and gizmos, too - bugged pens and grungy hackers. I reckon Trevor Eve to front it, with a fat guy and a black girl as back-up. He could be having an affair with the black girl, to give a bit of back story. Hell, he could be having an affair with the fat guy, too, if you think the audience is ready.
No? Well, what about a series based on the emergence of forensic science in Victorian London? Remember, The Alienist is a bestseller and later this year Carlton has got Bramwell, a series about a Victorian woman surgeon. Corsets are going to be big. The angle here is to get beneath the standard Victoriana into something more accurate, the world of Mayhew not Conan Doyle. You have this dark squalor up against the new science. It is an inverted nostalgia - however bad the present is, the past was worse. There is also a sort of buried "Two Nations" thing there which might touch a nerve. Think about it, anyway. Call me.
At which point the more experienced commissioning editor might point out that every one of these programmes has already been broadcast. The youthful John Thaw appeared in Redcap in 1965, though ABC's budgets meant that Germany and Borneo had to be re-created in the studio. A year later Edward Judd turned up in Intrigue, an unsuccessful 12-part series about a detective working for industrial clients. And the Victorian policeman idea first made it to the screen in 1963, when ATV transmitted Sergeant Cork, starring John Barrie.
It does not actually matter that they have been on before - indeed, it may even be an advantage. Because if you look closely at the history of crime fiction on television, it soon becomes clear that the best metaphor for the way new programmes are introduced to the schedules is crop rotation, a calculated husbandry of the audience's capacity to get excited. As the yield from one style of police drama begins to fall away, writers and directors move on to plough a different field. A period dominated by thick- ear, wheel-squealing dramas such as The Sweeney (almost immediately imitated by the BBC's Target) will be followed by a fashion for oddball detectives, for loners and outsiders. There are very few new ideas - just the dependable amnesia of the audience and the dependable satisfactions of the old genres.
It is risky to draw large conclusions from these swirls of fashion. It might be tempting to see the social history of post-war Britain reflected in the growing cynicism of police drama, in its rough progression from ingenuous admiration to suspicion and cynicism, but the chronology is never quite so obliging or one-directional. It is clearly true that we have come a long way from Fabian of Scotland Yard (first broadcast in 1954) to get to the sardonic ambiguities of Between the Lines but, in truth, it is a journey that has been made before. Z-Cars shocked its first viewers by the grittiness of its characterisation - its policemen drank, got things wrong, even beat their wives - but, for all its transforming realism, Z-Cars did not rule out a return to the reassuring innocence of Heartbeat, a Nineties show with a Sixties setting and mentality to match. Dixon of Dock Green, the very epitome of consolatory police drama, actually overlapped for a time with The Sweeney, a conjunction that now seems unthinkable.
The signs are that the pendulum is swinging back again, to a simpler, far less agonised style. Carlton's The Thieftakers, a recent pilot for a new Flying Squad series, actually concluded with the words "You're nicked", a cheeky homage to the clich that had come to sum up the shortcomings of its famous predecessor. There is a mood of considered nostalgia at the BBC as well. Far from believing that there were too many police dramas, Nick Elliott, head of drama series at the BBC, was sure there were too few when he first arrived, charged with recapturing the mainstream audience for the corporation. "There had been an awful lot of police shows at ITV, but there was nothing here really,'' he says. "In terms of a mainstream police series, I don't think there were any at the BBC." In his view, the fields had lain fallow for too long and the time was right for a return to some of the traditional formats - "men jumping out of vans" in the industry shorthand. Jo Wright, producer of Out of the Blue, a police procedural series due from the BBC next month, makes the same point. "When people say `Not another cop show' it makes me laugh because there are very few and the BBC hasn't had one for a long time ... There have been loads of detectives but not an ensemble police show."
Such technicalities are unlikely to console those, like the writer Andrew Davies, who see crime fiction as having television executives in an imaginative armlock. For Davies, the frenzied quest for a new angle, the attempt to flog the old forms into a semblance of novelty, is a tragic waste of airtime. It is easy to see what he means - the increasingly desperate attempts to refresh the private eye format brought little to the screen but a Cook's tour of ethnic minorities, British provinces and odd jobs. We were given black detectives, Chinese detectives, disc jockey detectives, Jewish detectives, cute girl detectives, little old lady detectives and restaurateur detectives. What next, one wondered? An Inuit detective, using his peerless knowledge of snow conditions to track down London criminals?
But Davies is wrong to think this is in any way a recent development - and almost certainly helpless in the face of the enduring appeal of crime fiction for a popular audience. He should, perhaps, thank his lucky stars that British television is as restrained as it is. In 1973, the peak of the American boom in crime series, such material accounted for 13 out of the season's 24 new shows and more than a third of prime-time viewing. The fact that America recovered from this addiction fairly rapidly may give him modest cause for optimism.
Besides, the disappearance of police fiction altogether is unthinkable, and not simply because it has always been central to all forms of mass entertainment, not just television. Crime fiction satisfies in us a secret yearning for justice, the unappeasable appetite for a fair world, which begins in childhood and never leaves us. It satisfies our need for conclusions, both moral and narrative. The earliest police fiction supplied this in the least sophisticated form - a world in which crime was reduced to a set of case histories, each satisfactorily sealed, without loose ends. "Crime, detection and arrest tends to provide a dramatic structure," Nick Elliott points out, "and there's a moral dimension to it. Basically you're on their side and basically they're on the side of good and against evil."
This remains true in even the most disenchanted police series. Successful cop shows are never truly cynical. The characters may wear a carapace of cynicism, may even drift outside the letter of the law, but we recognise it as their armour against the disappointments of human justice. They always, finally, care how the story ends, either serving as representatives of our own frustration or deliverers of an approximate retribution.
Moreover, the very familiarity of crime drama only increases its grip on the schedules. Commissioning editors anxious to increase their audience figures know that it provides the imaginative equivalent of a pre-sale, a familiar format in which viewers will rapidly find their feet. They do not have to worry about the genre, only this particular manifestation of it. And there are opportunities for writers, too. "The opening episode doesn't have to set up the procedure," explains Jo Wright. "It's very liberating, particularly with a character-based show like ours because you don't have to keep telling the audience what they do."
This suggests that good writers might do better to bend the the genre to their own ends rather than protest ineffectively about its predominance. Police series will continue to be a pillar of the schedules and history suggests that the same old formats will take their turn in the rota of fashion. But that is not necessarily a cause for creative despair. Sometimes the execution matters more than the form. As Cracker and Between the Lines triumphantly demonstrated, something that looks reassuringly like a conventional crime fiction can actually deliver something quite different. What appeared to be a hollow convention turns out to be a Trojan horse in the living room.Reuse content


text:
Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
If you are reading this message, Please click this link to reload this page.(Do not use your browser's "Refresh" button). Please email us if you're running the latest version of your browser and you still see this message.
Newegg.com - Computer Parts, Laptops, Electronics, HDTVs, Digital Cameras and More!
Showing Results: Most Recent
This review is from: Rosewill RCW-608 - USB 2.0 Adapter for IDE / SATA Device, Protective Case Included
Pros: Works with windows 7 out of the box
Cons: noneREAD FULL REVIEW
This review is from: Samsung Galaxy Nexus GT-i9250 16GB storage, 1 GB RAM White 16GB Unlocked GSM Android Smart Phone w/ Android 4.0 / 5 MP Camera / NFC 4.65"
Pros: Pure google
Cons: Return for refund within: 30 days
Return for replacement within: 90 days
90 day warranty provided by Brainstorm
This review is from: Patriot 8GB microSDHC Flash Card Model PSF8GMCSDHC4
Pros: Fast, works great in my G2 (htc)
Cons: None.READ FULL REVIEW


text:
I pick things up and put them down
View Single Post
Senior Member
Max Brawn
Join Date: Jun 2012
Location: Hastings, Florida
Posts: 3,348
Training Exp: 3.5 years
Training Type: Powerlifting
Fav Exercise: DEADS
Fav Supp: food
Reputation: 321283
I also have an orthopedic guy who is a power lifter...IT'S GREAT, they understand our needs, and more importantly, they realize we are still gonna lift, so they taylor rehab around what we CAN do.
enjoy your vacation Fen!
Best Gym Lifts...Dosen't matter....they don't count!
Best Meet Lifts:
Squat = 330
Bench = 215
Dead = 375
Total = 904
The iron is there during my times of happiness, sadness and anger. The iron is there available through the 4 seasons and inclement weather. The iron is there to either comfort me or motivate me. The Iron manages to show me how strong I am or how humble I need to be. The iron does not yell, but it always demands respect. The iron is not a disciplinarian, but when disrespected, I feel it for a long time. The iron does not love or hate, but we definitely share a strong bond. And no matter how far I stay away or for how long, the iron is there, waiting to be lifted.
Sponsored Links
View Public Profile
Send a private message to moeheep
Find More Posts by moeheep


text:
Using social media to build engagement
Following the release of the award-winning documentary Bully (2012), HI undertook an independent study to measure the film's influence in online social networks. Directed by Lee Hirsch, Bully is a cinematic, character-driven documentary that explores the issue of bullying at the heart of American schools. Embedded in schools and communities, the filmmakers present a personal view of this social issue and showcase the work of those who are fighting for change. Over a five-month period HI followed the response to the film on social networks.
A variety of technical platforms provided data to track social media activity around Bully. To measure engagement and behavior over time, HI researchers analyzed data from bitly, a popular link shortening service. For more in depth analysis researchers used social media analysis platform Crimson Hexagon to track conversations and measure sentiment on a variety of social networks. Together, these sources returned almost 200,000 posts for analysis. HI drew on new research in the computational social sciences to assess impact using these large data sets.
The report examines the remarkable success of Bully's social media campaign and offers implications for media makers who wish to use social media. More broadly, it explores the unique characteristics of online communication regarding social issues.


text:
Wego.com.sg recently found 67 hotels in Riomaggiore, Italy. Find a range of accommodation in Riomaggiore at great prices. Book luxury Riomaggiore hotels or find last minute accommodation. Save more on cheap hotels in Riomaggiore with affordable room rates.
Filters help you save time when choosing where to stay. Try clicking on a few now...
Riomaggiore Hotels 4 Star Hotels Riomaggiore 3 Star Hotels Riomaggiore Cheap Hotels Riomaggiore Cheap Accommodation Riomaggiore
Flights to Italy Flights from Italy Italy Airports Italy Airlines


text:
Cystic fibrosis (CF) is a life-limiting disorder of fluid and electrolyte transport affecting 70,000 individuals worldwide. Patients with CF carry loss of function mutations in each CF Transmembrane conductance Regulator (CFTR) gene. CFTR encodes a cAMP-activated chloride channel that is critical for proper hydration of mucous secretions in the pulmonary airways and pancreatic ducts and maintaining the correct concentration of chloride in sweat. Recently, treatment of CF has taken a major step forward with successful clinical trials of Kalydeco (VX-770), a potentiator compound that increases the function of CFTR bearing the G551D mutation (~2-3% of CF alleles) leading to reduced sweat chloride concentration ([Cl-]) and improved lung function measurements. The success of Kalydeco has fostered the development of numerous other compounds that can correct misfolded forms of mutant CFTR ("correctors") and additional compounds that "potentiate" CFTR that does not conduct chloride at wildtype levels. We now stand at the threshold of being able to treat CF at its root cause;however, there are substantial challenges in delivering molecular therapy to all CF patients. First, there are many different missense and in frame deletion mutations in CFTR (n=816) that a clinical trial for each mutation is not feasible. Second, we don't know if transient increase in CFTR function translates into long-term improvement in lung disease, the major cause of mortality in CF. Third, as lung disease in CF proceeds over many years, we need to gauge effectiveness of CFTR-directed treatment using 'short-term'clinical endpoints. Key preliminary observations suggest that we can address each challenge. CF-causing missense and in frame deletion mutations (n = 47) clustered into groups according to their effect on folding and/or chloride conduction of CFTR appear to correspond to corrector or potentiator responsiveness. Analysis of ~23,000 patients in the CFTR2 database (cftr2.org) revealed that CFTR chloride channel function (as % of wildtype) transformed to a logarithmic scale correlates with cross-sectional lung function (r = 0.43;p = 0.002) and with sweat [Cl-] (r = 0.80;p= 1.3 x 10-11). The overall goal of this application is to inform treatment of CF with CFTR-directed therapies by advancing our understanding of the relationship between CFTR function and clinical manifestations. This goal will be achieved by 1) Classifying CF-causing mutations according to their effect on folding and/or conduction to assess their likely response to current and future CFTR-directed therapeutics;2) Determining the extent to which longitudinal lung function correlates with in vitro CFTR molecular defects and 3) Determining if longitudinal measures of lung function correlate with in vivo CFTR function as measured by sweat [Cl-]. Upon completion of these aims, we will have mined the CFTR2 database and correlated phenotype data with in vitro properties of CFTR mutants to maximize the number of CF patients eligible for CFTR-directed therapy, to estimate the benefit of molecular therapy on long-term lung function in CF patients and to validate the use of sweat gland function to monitor the effectiveness of CFTR-directed treatment.
Cystic Fibrosis (CF) is a life-limiting disorder caused by mutations in the CFTR gene that affects 70,000 individuals worldwide. The overall goal of this proposal is to understand the consequences of different mutations upon the function of CFTR and the severity of CF. This information will be invaluable in predicting outcome for CF patients and evaluating the potential of therapies targeted at specific mutations in CFTR.
|Sosnay, Patrick R; Siklosi, Karen R; Van Goor, Fredrick et al. (2013) Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet 45:1160-7
|Sosnay, Patrick R; Castellani, Carlo; Corey, Mary et al. (2011) Evaluation of the disease liability of CFTR variants. Methods Mol Biol 742:355-72
|Blackman, Scott M; Hsu, Stephanie; Vanscoy, Lori L et al. (2009) Genetic modifiers play a substantial role in diabetes complicating cystic fibrosis. J Clin Endocrinol Metab 94:1302-9
|Krasnov, Kristina V; Tzetis, Maria; Cheng, Jie et al. (2008) Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships. Hum Mutat 29:1364-72
|Buranawuti, Kitti; Boyle, Michael P; Cheng, Suzanne et al. (2007) Variants in mannose-binding lectin and tumour necrosis factor alpha affect survival in cystic fibrosis. J Med Genet 44:209-14
|Sheridan, Molly B; Fong, Peying; Groman, Joshua D et al. (2005) Mutations in the beta-subunit of the epithelial Na+ channel in patients with a cystic fibrosis-like syndrome. Hum Mol Genet 14:3493-8
|Hefferon, Timothy W; Groman, Joshua D; Yurk, Catherine E et al. (2004) A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing. Proc Natl Acad Sci U S A 101:3504-9
|Groman, Joshua D; Hefferon, Timothy W; Casals, Teresa et al. (2004) Variation in a repeat sequence determines whether a common variant of the cystic fibrosis transmembrane conductance regulator gene is pathogenic or benign. Am J Hum Genet 74:176-9
|McWilliams, Rita; Hoover-Fong, Julie; Hamosh, Ada et al. (2003) Problematic variation in local institutional review of a multicenter genetic epidemiology study. JAMA 290:360-6
|Swiatecka-Urban, Agnieszka; Duhaime, Marc; Coutermarsh, Bonita et al. (2002) PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 277:40099-105
Showing the most recent 10 out of 26 publications


text:
Red Movies
Sara Suicide
Suicide Girls must STRIP
Sex is better than suicide !!!
Fat 'n' pierced Sara Suicide gets her twat rammed
Suicide - No - Public masturbation
Suicide Gal pulling tricks on the side
Magdalena - Suicide Blonde Fucked Anal
VCA Suicide Girls Porny Monster Gothic Sluts.DVDRip.XxX
Suicidal Chick Stops Her Man Cheatin'make pussy yeast Cake
Dumb ass Made love to this crazy suicidal young girl
Pale Black Hair and Nervous Emo Suicide Girl
Pierced porker Sara Suicide gets her twat rammed
TOLLY CRISTALL VS YANKI (ella se suicido) BY Eldoctorlecter
suicide girls
Syra Suicide vs BBC Byron
Pale Black Hair and Nervous Emo Suicide Girl Naked for the First Time
Kealy Kennedy Suicide Girl EMO 18yo exgirlfriend - Hard working little slut huge Cumshot (kealy)
Blonde Tattooed Suicide Girl Strips Naked for Cam
Gothic suicide babe with pierced nipples and tattoos
suicide girl blowjob
Alternative Couple
Pierced and tattooed asian suicide girl Ruby
Suicide Girls 2
Tattooed Suicide Girl with shaved pussy
XXX Suicide Emo bitch with pierced nipple webcam show
Teen plumper Sara Suicide takes fat cock
Gothic emo girl masturbating her shaved pussy
Sara had hardcore sex
Pierced and tattooed XXX Suicide slut drilled hard
Pierced and tattooed suicide babe taking cock doggy style
Tattooed emo goth babe fucked doggy style
Tattooed and pierced XXX Suicide babe with dildo
Tattooed suicide girl taking cock in ass and pussy
Tattooed and pierced XXX Suicide goth girl blow job
Super cute emo webcam model with rosebud in her ass
Perfect gf saves friend from suicide with a bang
poppin-the-pudge-2-scene 5
Nasty emo suicide girl in old lingerie fucks and sucks a dildo
Spanish Suicide Girl loves to suck and fuck
Teen plumper Sara Suicide is filled with hard cock
Syra Suicide - Super Hot Brunettes Join In A Threesomes And Enjoy A single Cock
Syra Suicide - Young chicks Blow A Huge Dick And then Get Banged
Little babe anorexic skinny girl fucked for money
Romance Burning Angel
pale black hair and nervous emo suicide girl naked for the first time