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Ischemia-reperfusion (IR) injury remains a major source of early mortality after lung transplantation. The objective of this proposal is to better understand the cellular mechanisms that initiate and mediate this inflammatory process. Our laboratory has established that lung IR injury is dependent on alveolar macrophage activation, CD4+ T cell infiltration, and TNF-alpha induction. Recent data also supports an important role for IL-17 and IL-17-producing CD4+ T cells, such as iNKT, in mediating lung inflammation after IR.
Thus Aim 1 will determine if iNKT cells initiate lung IR injury and neutrophil infiltration via IL-17 production. Oxidative stress and the release of reactive oxygen species via NADPH oxidase is also a component of IR injury as well as phagocytic cell activation.
Thus Aim 2 will determine if NADPH oxidase-generated ROS is a key mechanism for the activation of iNKT cells after IR. Our overall hypothesis is that lung IR injury is initiated through CD4+ iNKT cell activation via production of IL-17 and NADPH oxidase-dependent ROS. Results from this proposal will help design successful strategies to improve outcomes in lung transplant recipients.
Lung reperfusion injury is a major complication after transplantation resulting in dangerous inflammation, higher post-operative mortality, and late complications including chronic rejection. The objective of this proposal is to better understand the cellular mechanisms that initiate and mediate lung reperfusion injury. Results from this proposal will help design successful strategies to improve outcomes in lung transplantations.
|Sharma, Ashish K; Mulloy, Daniel P; Le, Lamvy T et al. (2014) NADPH oxidase mediates synergistic effects of IL-17 and TNF-* on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. Am J Physiol Lung Cell Mol Physiol 306:L69-79
|Sharma, A K; LaPar, D J; Stone, M L et al. (2013) Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. Am J Transplant 13:2255-67
|Lapar, Damien J; Hajzus, Vanessa A; Zhao, Yunge et al. (2012) Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling. Am J Respir Cell Mol Biol 46:299-305
|Laubach, Victor E; French, Brent A; Okusa, Mark D (2011) Targeting of adenosine receptors in ischemia-reperfusion injury. Expert Opin Ther Targets 15:103-18
|Sharma, Ashish K; LaPar, Damien J; Zhao, Yunge et al. (2011) Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Am J Respir Crit Care Med 183:1539-49
|Sun, Jie; Cardani, Amber; Sharma, Ashish K et al. (2011) Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus. PLoS Pathog 7:e1002173
|Sharma, Ashish K; Laubach, Victor E; Ramos, Susan I et al. (2010) Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 139:474-82
|Yang, Zequan; Sharma, Ashish K; Marshall, Melissa et al. (2009) NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury. Am J Respir Cell Mol Biol 40:375-81
|Yang, Zequan; Sharma, Ashish K; Linden, Joel et al. (2009) CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg 137:695-702;discussion 702
|Sharma, Ashish K; Linden, Joel; Kron, Irving L et al. (2009) Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respir Res 10:58
Showing the most recent 10 out of 23 publications


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This garment has a small percentage of elastane to provide stretch leading to greater comfort and adaptability. Additionally, it is also circularly woven eliminating seams thus increasing comfort still further. ETXEONDO DETAILS
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New York Style Chili
20 Aug 2010
Ingredients1 tablespoon olive oil
2 pounds New York Style hot sausage or chorizo, casings removed
2 large onions, finely chopped
4 garlic cloves, finely chopped or crushed
1 tablespoon finely chopped shallots
2 celery stalks, finely diced
3 15- to 16-ounce cans ki
1. Heat olive oil in a frying pan over medium heat. Add sausage and cook, stirring to crumble into pieces, for 6 minutes, or until lightly browned. Remove sausage and set aside. Drain off any fat.
2. Add onions, garlic, shallots and celery to the pan. Sau
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New York Style Chili Recipe


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A Mother's Day Tribute to Wyoming's Nellie Tayloe Ross
A mother's work is never done. Especially for the incredible working women who juggle the demands of raising a family and paying the bills...
A mother's work is never done. Especially for the incredible working women who juggle the demands of raising a family and paying the bills...
With Mother's Day fast approaching the age old question, "what to buy mom on her special day?" arises. We all strive to get the perfect gift for the one who has given so much to us. So my advice is not to over-complicate things.
If you're looking for last-minute Mother's Day gifts, you can't go wrong with a pair of galoshes and an umbrella this weekend.
It's hard to find the perfect gift for Mom. She takes care of you, listens to your problems, loves you when you're at your lowest, and will do anything she can to make sure your life goes as smooth as possible. How could you possible repay all of that with a simple gift?
Mother's Day is May 12th, and quickly approaching. Do you have any special plans or gifts to show your appreciation for your mom? If not, you are in luck. Here are some ideas to help you on your quest for the perfect Mother's Day.
Whether you've already splurged on mom or are panicking at the last minute to find an easy way to show your appreciation for all she does, have no fear. The Internet is here to save the day with online Mother's Day cards.
Kellan Grogan, the son of Tom and Sommer Grogan of Casper, was born on Christmas Eve 2010, and due to his health complications, had to be sent to Denver, CO via Air Life. Kellan, Tom and Sommer spent 3 months in Denver while Kellan healed from his numerous surgeries. While in Denver, Tom and Sommer were able to stay at the Ronald McDonald House, allowing them to be close to their son, while easing their financial burden.
My Country 95.5 would like to congratulate Amy Jackson for snagging her mom "My Country Mom of the Year" honors!
Amy's mom will be enjoying an awesome spa getaway at Season's Day Spa – where she'll get a day filled with the relaxation and pampering...
If there's one talent moms have, it's their killer poker face. That's why you may not have noticed any disappointment from gifts you've given her on a holiday, birthday or Mother's Day in the past, from macaroni necklaces to wilted bouquets. And though we're sure you've given her lots of things she adores, you don't want to make the mistake of giving her something she doesn't.
Here's a list of five things to avoid handing over on Mother's Day:
Mother's Day is close – and 95.5 is on the hunt for the My Country Mom Of The Year! The lucky winner will get a luxurious spa day at Season's Day Spa. She'll get a facial, Swedish massage, plus a manicure and pedicure – and some much needed "me" time. Check out the submissions and then place your vote - did we mention that you get 2500 My Country Club points just for voting?!
Whether you've already splurged on mom or are panicking at the last minute to find an easy way to show your appreciation for all she does, have no fear. The Internet is here to save the day with online Mother's Day cards. Some showcase your sense of humor, some get all mushy gushy and heartfelt, but all are delivered instantly with no postage cost.
If you really think about it, Mother's Day is the perfect opportunity to make up for all those times you gave mom a hard time during your youth. After all, a bouquet of daffodils now definitely excuses that time you snuck out of the house at 2 am. And a box of gourmet truffles? The perfect antidote to the antique china you broke while running around like a wild banshee.
But while flowers and chocolate are dandy, they don't last long. Treat Mom to one of these five Mother's Day gifts she'll both use and love for years to come:


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Caol Ila was founded to the North of Islay in 1846 by the pleasingly-named Hector Henderson. It is located near Port Askaig and sits in lush, floral surroundings, overlooking the cove and the Paps of southern Jura. The distillery draws its water from Loch Nam Ban, whose waters travel through limestone and peat before reaching their beneficiary, Caol Ila. The whisky distillery was sold to Norman Buchanan in 1852 and then, following monetary hardship, to the Glasgow-based blenders Bulloch, Lade and Co who renovated the buildings in 1879. Following liquidation, Distillers Company Ltd acquired Caol Ila and the distillery was subsequently transferred to Scottish Malt Distillers. The capacity is moderate at 3.65 million litres annually, the majority of which is used in Johnnie Walker blends. Just 5% is kept for maturation as single malt. From 1999, unpeated single malts have been experimented with and in 2006 the first unpeated bottling was released in the form of an eight year-old. Caol Ila, whose name derives from the Gaelic for 'Sound of Islay', has been included in the Diageo Classic Malts range, exhibiting twelve and eighteen year-old expressions as well as a Moscatel-finished Distillers Edition. Independent bottlings can also be found.
A cracking single cask bottling of 18 Caol Ila single malt Scotch whisky, presented as part of the Old Malt Cask range by Hunter Laing. This Islay single malt was distilled in September 1996 and… More info
This is a nineteen year old Caol Ila from The Cooper's Choice range bottled at 46% abv. Caol Ila is a peated malt whisky with a coastal character. More info
This 19 year old single malt Caol Ila laughs in the face of chill-filtration! It was drawn from two hogsheads by Signatory, producing 692 bottles of scrumptious Islay whisky. More info
An Islay Old Particular here, distilled at Caol Ila in September 1996 and matured in a single refill hogshead cask until December 2015. The outturn was 313 bottles at 51.5% abv. More info
A single cask bottling of 19 year old Caol Ila, distilled in September 1996 and bottled in June 2016. This was aged in a refill hogshead, which was cracked open and drained of the delicious whisky it… More info
A 19 year old Caol Ila, presented as part of the long-running Old Malt Cask range of independently bottled whiskies. The whisky was put into its hogshead by the Islay-based distillery in August 1996… More info
Smoky and rich, this is a full-bodied, powerful Caol Ila with notes of Latakia. Distilled in 1980 and bottled in 2011 by Berry Brothers and Rudd. Cask 4938. More info
A teenaged Caol Ila bottled by Gordon and MacPhail as part of their renowned Connoisseurs Choice range. More info
A single cask Caol Ila, bottled by the world-famous London wine merchants, Berry Brothers and Rudd. This was distilled in 1982 and aged in cask 6510 for 29 years before bottling in 2011,… More info
Distilled at Caol Ila in 1983 and bottled in 2011 at cask strength by Berry Brothers and Rudd. More info
From Berry's whisky selection comes this single cask Caol Ila distilled in 1983 and aged for 28 years in cask 4825 before bottling in 2011. More info
A 25 year old Caol Ila bottled for Berry's Own Selection. This was distilled in 1984 and bottled at cask strength. More info
A limited edition sherry finished single malt from Caol Ila, just 280 bottles were released, distilled in 1984 and bottled in October of 2008 by Gordon and MacPhail, a beautifully balanced whisky… More info
A rare half bottle of Caol Ila from Signatory, these are rather hard to come by. More info
Whisky Magazine Recommended, this 13 year old from Caol Ila offers textbook sweet smoke and oily, herbal, medicinal notes. Bottled for the Coopers Choice range. More info
Distilled at Coal Ila distillery in 1995 and finished in Madeira casks, this Islay single malt was bottled by Gordon & MacPhail for their Private Collection range. More info
An 11 year old Caol Ila expression from Gordon and MacPhail's Private Collection, this bottling was matured in Marsala casks and is part of an limited release of just 1,200 bottles. More info
A sherry finished distillers edition from the Caol Ila distillery. Distilled in 1996, the Moscatel wine has coalesced beautifully with the smoked power of the Islay single malt, the feinty notes are… More info
Distilled at the Caol Ila distillery in 1996, Gordon and MacPhail matured this in their Elgin-based warehouses in refill sherry casks. The result is a rich, coastal dram, with fruity freshness and… More info
This 1996 vintage bottling from Gordon and MacPhail's Connoisseur's Choice is a veritable exhibition of Caol Ila's character, there is a fruity freshness underpinning phenols and a strong coastal… More info
A beautiful Caol Ila from Gordon and MacPhail. This was distilled in 1997 and it was aged for a decade in bourbon casks before a 30 month finish in Hermitage wine casks (a classic French red made… More info
1997 vintage Caol Ila, bottled as part of Diageo's superb Distillers Edition range. This was finished in Moscatel wine casks, and the result is a nuttier, fruitier whisky. Well worth a try. More info
This is a sherry-matured Caol Ila from Gordon and MacPhail's Connoisseurs Choice range. It was distilled in 1998 and bottled in 2010. More info
A special Caol Ila and the latest in a line of fantastic whiskies in the Distillers Edition range. The whisky has been double matured, first in American oak casks then a second maturation in casks… More info
A cracking Caol Ila bottled by Gordon & MacPhail for their Connoisseurs Choice range. More info


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Call our experts: 888.808.FINE
Custom Stationery from luxury designers!NEW! Wedding Invitations Customize any Address Stamp to match your style!
Select a quantity and printing method. Changes are easily made later.
This tall white menu card features an orange flourish at the top which houses the text of your choice. Add all of your delectable menu choices to complete the look.This soothing, yet bold design takes inspiration from Shawn's love of succulents.


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double glasing repair brockley
double glasing repair in brockley
Our experienced and friendly staff can quote you immediately to replace any glass in any window or door, single or double glazed (DG Guaranteed for 10 years) all of our work is fully guaranteed. We offer an emergency service at no extra cost. Within the hour or at a time that suits you.
We offer professional services by qualified double glasing repair, fully experienced and covers all of the brockley area
Our full list of services include Shop Front Replacement, Double Glazing, Mirrors, Glazing Repairs, Porches, UPVC Repairs, New UPVC doors/handles and hinges, Frames, Cat Flaps fitted, Lead light repairs. Toughened glass is typically four to six times the strength of annealed glass.
Emergency Callout 365 days a year 24 hours a day. Express service.
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Drodesera 2010
Being Thirty
The performing art festival in Fies
Drodesera, the festival of entertainment, performing art and experimental theater, turns 30. An important anniversary to be celebrated with an eventful program, from July 23rd to August 1st, in the still working power station of Fies, right in the middle of the Marocche di Dro nature reserve (Trento).
There will be 17 groups, 7 visual artists, 33 shows, 2 national premieres and 7 worldwide premieres, the majority of them being Italian, to prove that the Bel Paese doesn't lack in creative energy and that the latter should be supported and fostered.
The organizers paid homage to some of the groups that participated to past festivals, since the 80s till today, by picking some of them for this year's festival: from historical Socìetas Raffaello Sanzio and Virgilio Sini, to Fanny&Alexander, Teatro Clandestino and Accademia degli Artefatti, the latter representing the Teatri 90 generation. The festival also wants to give space to young talents: Teatro Sotterraneo, Pathosformel, Dewey Dell, Masbedo, Francesca Grilli, Santasangre and very young Androgynous e Anagoor, just to mention some.
Among the themes: reflections above wars between Western and Eastern countries, the quest for identity, journeys into unknown territories, urban research, utopias, mirage cities, advertising language. A mix of contents which represent contemporary society, even quoting Hitler (in Fanny&Alexander's show), or staging musical goldfish (Quiet Ensemble) to generate childish wonder, which, unfortunately, people tend to loose at 30.
There will also be new things like the visual art of White Clinic: a container to show art videos and installations.
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Menswear and womenswear collections will walk together and will be on sale right after the show. These are the news from Burberry but the evolution is generalized: runway shows are changing


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Frontline tells the story of John O' Neil who became obsessed with Al Qaeda while he was at the FBI. He became head of security at the World Trade Center and died in the attacks there.
The documentary is called The Man Who Knew and will air Thursday on most PBS stations. After the broadcast, there will be an extensive website and the entire program will be available online. The New Yorker did a story on O'Neil in January.Powered by Sidelines


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U.s. 40 & Dan Jones Rd, Plainfield, IN 46168Request info Add to list
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U.s. 40 & Dan Jones Rd is aland property for lease in Plainfield, IN.
Located on the main retail corridor in Plainfield, IN, each outlot has great visibility situated on major roads at both Meijer entrances. The trade area of Plainfield, a vibrant growing community with 35,000 residents in a 3-mile radius, is only 5 miles from the Indianapolis International Airport and 13 miles west of downtown Indianapolis, easily accessible via I-70.
Join Meijer and Walgreens in the growth corridor at Hendricks County. Diverse retail, industrial, office, and residential sectors have contributed to the community's growth and success.
> Outlot A 3.15 Acres - Ground Lease/Build to Suit (divisible)
> Outlot B 2.11 Acres - Ground Lease/Build to Suit/For Sale
> Graded outlots with utility leads
> Storm water detention in place
> Zoned GC
> 23,000 VPD (U.S. 40) & 10,239 VPD on Dan Jones Road
> Pylon signage available
Located on the west side of Dan Jones Road, in front of the new Meijer, just north of US 40 in Plainfield.
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Tumi New York CityStore's name : Gracious Home
Address & Contacts
1992 Broadway
10023 New York City
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- Tumi in New York City 10 Columbus Circle
- Tumi in New York City 2205 Broadway
- Tumi in New York City 1420 6th Ave.
- Tumi in New York City (0.06 km)
- Tumi in New York City (0.38 km)
- Tumi in New York City (0.8 km)
- Latitude : 40.77505
- Longitude : -73.982059
Your opinionYou are a customer or you know Tumi New York City ? Help future customers by leaving your review and rating this store!
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For most frequent travelers, the Tumi brand is a common one because of the traveling bags and suitcases that are famous across many countries in the world. This brand has a genesis that begins from way back in 1975. The name originated from a Peruvian god highly respected by the founder especially during the days as an ardent believer in… more about Tumi
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[author: Christopher D. Heer]
While Canadian patent prosecution is similar to U.S. patent prosecution in many respects, there are also some differences to be aware of as an instructing agent in order to better prosecute Canadian cases.
In Canada, advanced examination may be obtained by opening the application to public inspection, paying the required examination and advanced examination fees and filing a statement that the failure to advance the application is likely to prejudice the applicant's rights. No affidavit or other evidence or documentation is needed. Once requested, advanced examination will commence within three to six months and further office actions will be issued at an accelerated pace as well.
If speed is not paramount, it is possible to proceed slowly in Canada and reduce prosecution overlap with other jurisdictions. Whereas examination of an application in the U.S. occurs after filing without further action by the applicant, examination of a patent application in Canada must be explicitly requested within 5 years of the filing date and accompanied by payment of a government examination fee. This enables a strategy for reducing global prosecution costs by delaying an examination request in Canada until claims have been allowed in a corresponding application in the U.S. or elsewhere.
There are no claim surcharges in Canada of any kind. However, there is a surcharge for patent applications exceeding 100 pages, which becomes payable after the application has been allowed.
In Canada, the prosecution history of a patent cannot be used for the purpose of construing patent claims in litigation, although it may be admissible for other purposes.
In Canada, the applicant is only required to identify or file prior art when the Examiner requests that the applicant identify the prior art cited in corresponding patent applications in other jurisdictions. There is no positive obligation to identify or file all known material prior art, although the applicant may voluntarily file prior art to ensure that it is explicitly entered on record.
There is no on-sale bar in Canada. Any prior sale has to constitute an enabling disclosure of the subject-matter of the invention in order to anticipate a patent claim.
While Canada also has a one-year grace period for enabling disclosures which runs back from the Canadian filing date (as opposed to the priority date), the one-year grace period in Canada only protects the applicant against other applications which are based on the applicant's prior disclosure. If an independent third party files an application during the grace period which is not based on information received directly or indirectly from the applicant, it will predate the applicant's filing and may preclude the applicant from obtaining patent rights.
Methods of medical treatment are not patentable in Canada. However, this is more a requirement of form than substance, as similarly-worded "use" claims are allowable in Canada.
Higher life forms, generally defined as multicellular life forms, are also not patentable in Canada. This includes animals at any stage of development from fertilized eggs and totipotent stem cells (which have the inherent ability to develop into animals) onwards, as well as plants, seeds and mushrooms. Lower life forms, generally defined as unicellular life forms, are patentable in Canada. Lower life forms include microscopic algae, unicellular fungi, bacteria, protozoa, viruses, transformed cell lines, hybridomas, and embryonic, pluripotent and multipotent stem cells.
There is no equivalent to a continuation-in-part application in Canada. The applicant must file a new patent application in order to claim the new subject-matter.
Moreover, due to double patenting laws in Canada, divisional applications are rarely employed other than those filed in response to plurality of invention rejections from the Patent Office.
There are annual maintenance fees payable in an application or issued patent from the second anniversary of the Canadian filing date to the end of the patent term. Maintenance fees for an application in Canada may only be validly paid by the agent of record.
Should a fee be missed, or an application go abandoned for any other reason, such as failing to timely respond to an office action, the application may be reinstated within 12 months upon making a request for reinstatement, paying a reinstatement fee and taking the action required which led to the abandonment. No explanation as to how the abandonment was unintentional or unavoidable is required.
Incorporations by reference in the patent specification are not permitted in Canada. Prior applications, patents and other documents may nevertheless be referred to in the specification, if they are public and sufficient identification of the public document is provided.
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
© Bennett Jones LLP
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text: Epic & Blues by OLUGBENGA. published on 2012-07-11T17:49:54Z You have probably heard lots about Olugbenga the DJ. Playing sets across the best clubs in the world in 2012 and dominating UK festival line ups including Field Day, Dot to Dot (In Bristol, Nottingham & Manchester) and Rockness. With Kendal Calling, Soundwave Festival Croatia and Summer Sundae still to tick off his list. We welcome you to this mesmerising insight into what to expect from Olugbenga - the producer. Epic & Blues is his unmissable debut release; A collection of Olugbenga remixes that have been reworked into original material. The remix parts have been stripped out and replaced with new original additions by Olugbenga. Epic & Blues is to be delivered in a series of free releases from Monday 16th July through to Friday 20th July. Each day of the working week will see a separate track released from a different online source. On Monday 23rd the full Epic & Blues mixtape drops, with the bonus of 2 additional tracks to add to this already stunning debut package. Olugbenga comments that 'Epic & Blues is comprised of wordless versions of remixes I've done in the last couple of years along with a couple of new original tracks. I'm giving it away for free, but in a way it feels like my first proper release.' You will of course have the chance to download all 7 of the tracks for free from this page! So please keep on checking back, leave a comment, favourite and share! In this digital era, unique and inspirational original material that you pay for is hard to come by. So please don't sleep on this exclusive release... SFM. Mixed by Ian Carter Mastered by Matt Colton at Air Studios London Artwork: Shaun Heath [SFM] www.facebook.com/thisisolugbenga www.twitter.com/oluolugbenga Genre Epic & Blues Contains tracks Love Is The Devil In The Details by OLUGBENGA. published on 2012-07-11T18:10:12Z Hexagons IV [Esben and the Witch] by OLUGBENGA. published on 2012-07-11T18:51:23Z Mistakes Mk 3 [Error Operator] by OLUGBENGA. published on 2012-07-11T19:05:14Z Ulysses [Jim Kroft] by OLUGBENGA. published on 2012-07-11T17:48:05Z Deeper Hidden Meaning by OLUGBENGA. published on 2012-07-11T21:06:05Z


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Eggplant Mexicano
Quick look
- prep 5 min cook 10 min
- serves 6
- 1/2 cup vegetable oil
- 1 teaspoon garlic powder
- 1 teaspoon dried oregano
- 1 medium eggplant, peeled and cut into 1/2-inch slices
- 2/3 cup salsa, warmed
- 1/2 cup shredded Monterey Jack cheese
- 1
In a bowl, combine the oil, garlic powder and oregano; brush over both sides of eggplant. Grill, uncovered, over medium heat for 4 minutes on each side or until tender. To serve, spoon a small amount of salsa into the center of each; sprinkle with cheese.
How to make it 15 minutes
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PROJECT 2: Molecular Inhibition of Apoptosis Inhibitors B-cell chronic lymphocytic leukemia [B-CLL] arises primarily because of failures in apoptosis mechanisms. Aberrant over-expression of anti-apoptotic Bcl-2 family proteins contributes greatly to the long lifespan of CLL cells, and also thwarts attempts to eradicate these leukemic cells by chemotherapy. The human genome contains six genes encoding anti-apoptotic Bcl-2 family proteins (Bcl-2, BCI-XL, Mcl-1, Bfl-1, Bcl-W, Bcl-B), several of which are often highly expressed in CLLs. Expression of Mcl-1 or Bfl-1 accounts for resistance to chemical antagonists of Bcl-2, such as ABT263 analogs. Moreover, expression of these pro survival proteins increases in CLL cells thriving in microenvironmental niches. We hypothesize that redundancy caused by multiple anti-apoptotic Bcl-2 family members is a critical barrier to effective treatment of CLL. We propose to test this hypothesis through 3 complementary approaches. First. ABT263 and other small molecule Bcl-2 antagonists currently in clinical development bind a regulatory site on Bcl-2, mimicking endogenous antagonists that contain the BH3 domain. We have generated novel BH3 mimicking compounds with broad-spectrum inhibitory activity against all anti-apoptotic Bcl-2 family proteins. These compounds will be tested for preclinical activity against primary human CLL cells in culture and against murine CLL cells in transgenic mouse models. Second, we have identified a non-BH3 regulator of Bcl-2 in the Nur77/TR3 protein, an orphan nuclear receptor that binds to Bcl-2, Bfl-1, and Bcl-B, converting these proteins from antito pro-apoptotic. Using Nur77/TR3, we have discovered a novel non-BH3 regulatory site on Bcl-2 family proteins that will be targeted with small molecules as an alternative approach to Bcl-2 antagonism. Third. expression of many anti-apoptotic Bcl-2 family proteins (including Mel-1, BCI-XL, and Bfl-1) is upregulated when CLL cells are influenced by microenvironment. Hence, agents from Aims 1 and 2 will be evaluated for activity against CLL cells using in vitro culture models of microenvironment interactions. Altogether, our goal is to extend preclinical studies of novel Bcl-2 family antagonists towards the ultimate goal of bringing these concepts and new agents into the clinic via the CLL Research Consortium (CRC).
CLL is the most common type of leukemia in the Western world, remaining incurable with currently available therapies. In this project, we propose to generate novel pro-apoptotic drugs and to elucidate synergistic drug combinations, creating novel strategies for the improved treatment of CLL.
|Mani, R; Mao, Y; Frissora, F W et al. (2015) Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia. Leukemia 29:346-55
|Veronese, A; Pepe, F; Chiacchia, J et al. (2015) Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia. Leukemia 29:86-95
|Woyach, Jennifer A; Furman, Richard R; Liu, Ta-Ming et al. (2014) Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med 370:2286-94
|Stephens, D M; Ruppert, A S; Jones, J A et al. (2014) Impact of targeted therapy on outcome of chronic lymphocytic leukemia patients with relapsed del(17p13.1) karyotype at a single center. Leukemia 28:1365-8
|Chen, Wenbing; Han, Yanyan; Peng, Xiaohua (2014) Aromatic nitrogen mustard-based prodrugs: activity, selectivity, and the mechanism of DNA cross-linking. Chemistry 20:7410-8
|Strati, Paolo; Ferrajoli, Alessandra; Lerner, Susan et al. (2014) Fludarabine, cyclophosphamide and rituximab plus granulocyte macrophage colony-stimulating factor as frontline treatment for patients with chronic lymphocytic leukemia. Leuk Lymphoma 55:828-33
|Cheney, Carolyn M; Stephens, Deborah M; Mo, Xiaokui et al. (2014) Ocaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia. MAbs 6:749-55
|Riches, John C; Gribben, John G (2014) Hanging tough: CMV-specific CD8+ T cells in CLL. Blood 123:608-9
|Cui, Bing; Chen, Liguang; Zhang, Suping et al. (2014) MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood 124:546-54
|Beckwith, K A; Frissora, F W; Stefanovski, M R et al. (2014) The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. Leukemia 28:1501-10
Showing the most recent 10 out of 227 publications


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- Video
No Videos Available
- Description
Fully waterproof breathable and built for the trail the Sierra Designs Women's Pack Trench is an excellent longer-length lightweight option for hikers and backpackers seeking reliable protection from wet or windy weather.
Offering pack-compatible 3-season protection the durable Women's Pack Trench keeps out rain and wind and offers high breathability. 100% nylon weave fabric features a DWR (durable water repellent) treatment while the nylon tricot backer feels smooth against the skin and doesn't stick to your arms in warmer temperatures keeping you dry and comfortable. This durable fabric can take the wear-and-tear of wearing a pack and offers drop shoulder seams to eliminate chafing. Adjustable tab-closures at the cuffs and a draw cord hem allow you to seal out the howling wind and nasty weather while simple underarm vents keep you cooler without the hassle of traditional pit-zips. An attached hood is designed to lay flat when down to prevent annoying bunching behind your head.
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Available in a variety of size and color options the Sierra Designs Women's Pack Trench offers a trim feminine cut that layers well over light to medium weight fleece sweaters or base layers. The longer-length design (32.5" center back length) protects the top of your pants to keep your hips dry.
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- Nylon tricot backer is comfortable next to skin
- Trim cut fits over baselayer and light midlayer
- Specs
Best Use Backpacking, Hiking Jacket Back Length Thigh-Length Center Back Length 32.5" Type Long Rain Jacket Shell Material 50D x 90D 100% Nylon Weave, 20D Knit Backer Number of Pockets 2 Item Weight 13 oz Hood Yes Fit Trim Cut
- Reviews


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Location: State College, PA, United States
Member Since: June 2008
Open for read requests: Yes
Short Story / Poetry
Short Story / Literary Fiction
Short Story / Literary Fiction
I write poems from time to time.
I try to experiment with stories to.
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boy meets world
6 perfect '90s TV shows that are overdue for a comeback
This isn't our nostalgia talking—it was truly TV's golden decade.
Why Jimmy Fallon's 'Saved by the Bell' reunion broke the Internet
The show isn't just a time capsule for a previous generation. It helped invent it.
'Girl Meets World' holds a Matthews family reunion in holiday episode
Topanga may have gotten to marry Cory, but fans know who the most important person in his life always was.


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Blogs // 1 Articles
Hannibal Buress: Live From Chicago
5 May 2014 // 8:03 PM
In what should have been a breakout album, Live From Chicago feels like a master storyteller retell jokes you've already heard.
20 Questions: Hannibal Buress
30 May 2012 // 2:00 AM
Hannibal Buress is blowing up: a new special on Comedy Central, a show on Adult Swim, and -- of course -- answering PopMatters' 20 Questions, revealing why he may wear the same pair of jeans for two weeks, wonders what a conversation with a drunken President Obama would be like, and how he'd love to see what cell phones would like like 50 years in the future . . .


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Visit Seattle
Explore the Pacific Northwest's Emerald Jewel
To visit Seattle is to experience a city of contrasts with a seemingly endless list of things to do, and a website representing the Emerald City not only required an intuitive user experience, but a strategy centered around meeting every visitor need and a powerful back-end engine to deliver third-party content across the site.Case Study
Evolving the Digital Branch
Fresh off a rebrand, WSECU came to Gravitate recognizing the digital apathy across its industry and sought to evolve and reimagine all current and potential digital properties to match its recent brand and core philosophy overhaul.Case Study
All Hands Volunteers
Inspiring Action
Teaming up with the do-gooders at AHV to produce a responsive, easy to manage website was empowering. Now they can tell inspiring stories of individual disaster relief efforts and engage potential volunteers and donors to learn more about AHV's backstory and initiatives.Case Study
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Gravitate is a full service, in-house digital marketing and design agency with nearly 20 years of experience in the creative industry. We develop integrated marketing solutions that drive business and boost revenue. We don't need to outsource your work overseas or to robots. We are real people, with a real passion for what we do – see for yourself.
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Ready to start a project or really curious about our process? Drop us a note or give us a call; we're happy to answer all your questions.Work With Us
Signs You're Ready to Start a Website Project
We collaborate with a variety of clients in multiple industries. Many of these relationships begin with a website project as the foundation for their renewed digital marketing efforts. No matter…
How to set a realistic timeline for your website project
One of the hardest things for companies to do is predict is how long their new site will take to build and launch. That makes sense, right? These companies don't…


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While a winter storm stranded passengers in St. Louis, one airline pilot played the piano for hours to ease the frustrations of the delayed travelers. VPC
United Express pilot Billy Hock went above and beyond Thursday to help keep passengers occupied in St. Louis, reports St. Louis TV station KSDK.
The station says Hock -- "stranded at Lambert International Airport along with 1,700 other people" -- decided to take to a piano in the airport in an effort to help soothe fliers stuck in the airport.
LOCAL REPORT: Captain Billy Hock plays piano for stranded travelers (KSDK)
KSDK reports "he played in Terminal 1 for about three hours as a mixture of snow and sleet covered the runway." Nearly 300 flights were canceled at St. Louis Thursday (Feb. 22) as a winter storm snarled flights throughout the central USA.
In its report, KSDK adds: "Captain Hock composes all of his music, and while passengers were tired he did bring smiles to their faces."
TWITTER: You can follow me at twitter.com/TodayInTheSky


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The incoming Obama administration will need some help to translate their enthusiasm for Web 2.0 tools to the government. And fortunately for them, the Federal Web Manager's council delivered such advice. A new White Paper details the government's 10 most significant barriers to using social networking tools such as Facebook, YouTube and My Space. On our continuing series Tracking the Transition, FederalNewsRadio's Jason Miller talks with Bev Godwin, director of USA.gov and Web Best Practices in the General Services Administration's Office of Citizen Services, about what the biggest challenges are and how they can be addressed.Click to hear the interview.
Photos of the amazing, moving, important and amusing things happening in the federal community.
A daily update of important moments in the history of the U.S. government.


text:
Town Square
Sort by: Most recent topic/comment Most viewed Most comments
Navigation tip: Clicking on any category label will display all recent posts in that category
AROUND TOWNMan struck, killed by train at Atherton station
A man was struck and killed by a southbound train at about 12:53 p.m. today (May 17) at the Atherton station, according to...Original post made on May. 17, 2015
Last comment by Peter Carpenter, on May 18, 2015 at 1:41 pm | 1 comment | 937 Views
PALO ALTO ISSUESHidden in plain sight
The young man working at a Mountain View Safeway slammed his head on a commercial refrigerator door, unable to verbally express...Original post made on May. 8, 2015
Last comment by Language Matters , on May 18, 2015 at 9:40 am | 28 comments | 17377 Views
AROUND TOWNPerpetual volunteer Ray Bacchetti dies at 81
For Ray Bacchetti, civic engagement wasn't a lofty ideal so much as a way of life. Bacchetti, a devoted educator, activist...Original post made on May. 11, 2015
Last comment by Penny Ellson, on May 18, 2015 at 2:21 am | 24 comments | 4551 Views
PALO ALTO ISSUESGunn installs first water bottle filling station on campus
Student organizations and individuals at a Palo Alto high school have unveiled the school's first water bottle filling station,...Original post made on May. 17, 2015
Last comment by Slow Down, on May 17, 2015 at 10:44 pm | 13 comments | 3464 Views
PALO ALTO ISSUESBreaking the silence
Robin Thomas matriculated at Stanford University in the fall of 2008, and after a few months he was thinking about leaving....Original post made on May. 15, 2015
Last comment by ADHD in PAUSD, on May 17, 2015 at 3:25 pm | 17 comments | 8652 Views
ISSUES BEYOND PALO ALTOanother caltrain fatality
This one was in Atherton: http://www.sfgate.com/bayarea/article/Person-struck-and-killed-by-Caltrain-6269282.php...Original post made by concerned on May. 17, 2015
There are no comments yet. 712 Views
PALO ALTO ISSUESPalo Alto flight instructor vanishes over Pacific
A 24-year-old Palo Alto flight instructor disappeared while flying over the Pacific Ocean on May 8, and Palo Alto police...Original post made on May. 16, 2015
Last comment by resident 1, on May 17, 2015 at 1:34 pm | 13 comments | 11102 Views
PALO ALTO ISSUESNew drought rules limit irrigation in Palo Alto
With the statewide drought lingering for the fourth straight year, Palo Alto this week adopted a new rule barring residents...Original post made on May. 13, 2015
Last comment by Craig Laughton, on May 17, 2015 at 1:11 pm | 57 comments | 10985 Views
SCHOOLS & KIDS"Why are Palo Alto's Kids...."?
http://www.modernluxury.com/san-francisco/story/why-are-palo-altos-kids-killing-themselves Dear Palo Alto Onliners, This...Original post made by Marc Vincenti on May. 17, 2015
There are no comments yet. 545 Views
SCHOOLS & KIDSIn school gardens, lessons are ripe for learning
"Our babies are turning gold!" a second-grader at Landels Elementary School in Mountain View exclaimed as he ran his hand...Original post made on May. 15, 2015
Last comment by former Sunnyvale parent, on May 17, 2015 at 12:12 pm | 3 comments | 6577 Views
SCHOOLS & KIDSPalo Alto's Lin dives to girls' title at the CCS Championships
Palo Alto junior Mimi Lin captured her first title on the 1-meter springboard in the girls' diving finals at the Central...Original post made on May. 17, 2015
There are no comments yet. 1759 Views
SCHOOLS & KIDSEditorial: With urgency, new schedule takes shape
Few would have predicted three months ago that a diverse group of Gunn High School teachers, students, parents and administrators...Original post made on May. 15, 2015
Last comment by Future Agenda, on May 16, 2015 at 8:05 pm | 9 comments | 4800 Views
AROUND TOWNEast Palo Alto starts a news service
East Palo Alto residents launched their own news service on Tuesday, April 28, in an effort to cover the city's news and...Original post made on May. 6, 2015
Last comment by Loretta, on May 16, 2015 at 6:10 pm | 10 comments | 6215 Views
SCHOOLS & KIDSThink Tank
Any feedback on the ThinkTank program? Is the Math and Science suitable for a regular ( not accelerated ) lane of middle...Original post made by Not Sure on May. 16, 2015
There are no comments yet. 554 Views
AROUND TOWNSmash-and-grab burglars hit Bloomingdale's at Stanford Shopping Center
Palo Alto police are looking for four people who drove a stolen sports utility vehicle through the front glass doors of Bloomingdale's...Original post made on May. 13, 2015
Last comment by Peter Carpenter, on May 16, 2015 at 7:59 am | 21 comments | 8253 Views
SPORTSEast Palo Alto teen was victim in trailer fire
He was the "king" of skateboarders in his hometown of East Palo Alto; the young man who always had a smile for everyone....Original post made on May. 9, 2015
Last comment by Illuminati, on May 15, 2015 at 8:55 pm | 8 comments | 8092 Views
PALO ALTO ISSUESBuena Vista appraiser threatens to resign
An appraiser tasked by Palo Alto officials with recalculating how much assistance residents of the Buena Vista Mobile Home...Original post made on May. 15, 2015
Last comment by Skeptical, on May 15, 2015 at 4:38 pm | 5 comments | 1288 Views
AROUND TOWNBenefit concert honors memory of Amelie Le Moullac
A benefit concert for children in Haiti and in memory of Menlo School graduate Amelie Le Moullac is set for 8 p.m. Saturday,...Original post made on May. 15, 2015
There are no comments yet. 2035 Views
SPORTSPaly wins SCVAL De Anza Division baseball playoff title
Getting a second chance has made all the difference in the world for the Palo Alto baseball team, which is the 2015 SCVAL...Original post made on May. 15, 2015
Last comment by arts supplement #1FAN, on May 15, 2015 at 1:32 pm | 1 comment | 1747 Views
AROUND TOWNMysterious meat sales concern Palo Alto residents
Barron Park neighborhood residents have been puzzling over mysterious meat salesmen in blue trucks who have been knocking...Original post made on Nov. 15, 2011
Last comment by Bernadette Hsing, on May 15, 2015 at 1:08 pm | 37 comments | 7847 Views
Happy Valentines – Let's Be Friends
By Laura Stec | 2 comments | 17,769 views
Our Valentine's Day baby
By Sally Torbey | 5 comments | 2,976 views
Engagement Rings: Myths and Options
By Chandrama Anderson | 1 comment | 1,165 views
Talking about baby
By Cheryl Bac | 0 comments | 786 views


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Shopper - black
Kaliber fashion
This shopper is perfect for carrying all your necessery items. It's easy to mix and match with your everyday outfit!
Height: 46 cm
Width: 43 cm
Strap length: 110 cm
Handle length: 55 cm
Color: black
Material: vegan suede, smooth leather (faux)
Designed and made in Berlin
Discover how Kaliber fashion benefits both people and planet here.


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Tamarind Rice
|400 Gram
|50 Gram
|Split black gram
|50 Gram
|Split bengal gram
|50 Gram
|Red chilies
|20 Gram
|1 Teaspoon (Leveled)
|Gingelly oil
|150 Gram
|1 Pinch
|To Taste
|To Taste
|Green chilies
|Ginger piece
|1 Small
|1 Pinch
|200 Milliliter (For Tamarind, Approximately)
1. Cook rice with salt, till just done, and cool.
2. Soak tamarind in water and extract the juice.
3. Roast black gram, Bengal gram and red chillies separately and grind to a coarse powder.
4. Heat oil, add asafoetida, mustard, peppercorns, turmeric, green chillies, ginger and chopped curry leaves.
5. When mustard seeds crackle, add tamarind extract, powdered spices and salt and cook till all water evaporates and mixture thickens.
6. Mix the tamarind mixture thoroughly with the rice, cover and serve hot.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 795 Calories from Fat 347
% Daily Value*
Total Fat 39 g60.5%
Saturated Fat 5.6 g28.1%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 114.4 mg4.8%
Total Carbohydrates 100 g33.2%
Dietary Fiber 5.5 g22%
Sugars 9.2 g
Protein 11 g22%
Vitamin A 2.4% Vitamin C 24.2%
Calcium 8.6% Iron 7.8%
*Based on a 2000 Calorie diet


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I've never quite been able to give up anime because it's a great way to keep the child in me alive. The child in me happens to be Sakura Kinomoto; the adult in me is turning day by day into Eva Heinemann. So you see the need.
My anime time includes writing reviews for Anime UK News and co-presenting what is arguably the UK's best anime podcast, Nakama Britannica. The latest episode is a review of FLAG, Ryousuke Takahashi's strange and unique war series. As for my tastes, I can forgive most flaws if a show offers well-crafted characters, and I sometimes watch shows just because nobody else has. Lastly, if you're looking for something fun to do, why not join in the awesome forum club, Find Your Anime Buddy! Go on… you know you want to.
*My rating scale: 1-3 (Poor); 4-6 (Average); 7-8 (Good); 9-10 (Masterpiece)
6,423 total episodes
Thank you very much for getting back to me! I did check out Anime UK's site the other day, and was a bit frustrated by its layout and navigation, but I will give it another try. I will definitely check out your reviews there, as good objective reviews seem to be so scarce! Will have a listen to the podcasts when I get a chance.
Are you still writing anime reviews? If so, I would love to know where I can read your latest reviews. Quite honestly, I think you're an excellent writer and your reviews have always been thoughtful and informative.
Funny, I hadn't thought about checking your profile until now. You've always seemed like a busy person to me, and now I see why.
Anyway, Katanagatari is long but seems good. I might pick it up again. I wish you the best on your podcast.
why do I have to use the captcha to say hi xD
Hey Vivi!
Ich dachte, ich sage mal 'Hallo'! (= Wie gehts dir denn?


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Surprise, Ariz., firefighters had to rely on instinct and telephone guidance from an expert when they received a call about an unresponsive cockatoo. The bird, named Rusty, was accidentally locked inside a truck along with his owner's keys and was recumbent in his cage by the time firefighters were able to open the vehicle. Firefighters gave Rusty oxygen, put ice packs under his wings and fanned and squirted him with water. The bird was taken to a veterinarian and is doing fine.
Full Story:KPHO-TV (Phoenix)


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http://www.youtube.com/watch?v=AQ0epCgQxjsAdd your comment...
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Added a new photo album my photography 2/14/2014 5:48 PM
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whats the name of the song???
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Added a new video Dean Cooper - 2013 bmx edit 2/14/2014 4:45 PM
filming with Dean Cooper at woking skatepark,sythwood skatepark and woking town centre. a Nikon D1300 and a GoPro Hero 2 were used to make this video, filmed and editied by Dean Cooper and Gary Greer with sony vagas 11 software. song: Lions - Nashville
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The bookmarks panel was turned into an arrow panel in bug 590105. We need to style this panel properly on mac.
Created attachment 498522 [details] [diff] [review]
This is all styling that's needed - ported from firefox. The only thing I've changed is some code-wise styling (also note that firefox uses pre-defined stuff in shared.inc which I had to excerpt)
Created attachment 498556 [details] [diff] [review]
Fixed some indentation, added html namespace & credits
jftr, our star icons doesn't really fit here and we should have a larger icon in the panel imo.
Created attachment 498652 [details] [diff] [review]
OK, so this is ready now. This is basically a straight port from Firefox's browser.css, main differences are:
- removed a lot of unneeded important rules (the ones that are left are needed)
- slightly different structure, elements with the same rules are put together (e.g hover:active, focus etc), I omitted the navigator-specific ones, since I think it's better to have them separate from a maintenance pow.
browser.css can btw probably live without the sorting, because they have shared.inc where they put the common rules.
Oh, then I discovered that our placeholder isn't set on the tags field - it almost got me mad, because I first thought that some style rule was wrong.
The focus ring on the +-button isn't 100% right, but it looks like that in FF as well and I haven't been able to fins out what's happening.
Created attachment 498655 [details] [diff] [review]
v1.0 for real
Whoops, forgot that I had a little hack in there - this one should be the right one.
Created attachment 498656 [details]
screenshots, before and after
This is nice, could you file a bug to have this done for non-Mac as well? We're missing a similar set of rules in the normal default theme files.
(In reply to comment #7)
> This is nice, could you file a bug to have this done for non-Mac as well? We're
> missing a similar set of rules in the normal default theme files.
Filed bug 620417.
Comment on attachment 498655 [details] [diff] [review]
v1.0 for real
But the "New Folder" button should have a tooltip - I involuntarily added a new folder to my bookmarks (which I couldn't even delete in that dialog!), because the function of that [+] is totally non-obvious.
r=me with that.
Landed with tooltip "Create new folder":


text:
$26.00 donated in past month
IMC Network
Alacatlatzala, Guerrero (video/mp4 46.4mb)
Posted: Thu Dec 15, 2016 8:11PM
Oklahoma Shaking (video/mp4 30.1mb)
Oklahoma has seen a dramatic increase in earthquakes in the last few years. These quakes are caused by deep underground injection of wastewater produced from oil and gas extraction activities. The activities including normal pumping, fracking and a process called dewatering....
Posted: Sat Nov 5, 2016 11:58AM
Trailer (video/mp4 54.3mb)
Here is a trailer:...
Posted: Wed Sep 14, 2016 8:28PM
Video: "Boycott Driscoll's" and "No More Blood Berries" from Mansion House (video/mp4 19.1mb)
Activists displayed a banner declaring "No More Blood Berries" from the roof of the Mansion House on Sunday, August 7 while shouting, "Boycott Driscoll's" and "...
Posted: Tue Aug 9, 2016 5:25PM
Oakland Special Meeting on Coal Tonight: Rev. Manning says, "No Coal in Oakland" (video/x-ms-wmv 76.8mb)
Video by Jonathan Nack Reverend Laurie Manning, of the Skyline United Church of Christ spoke out against the proposed coal terminal at a rally opposing it held on Saturday....
Posted: Mon Jun 27, 2016 3:33PM
Street Interview with UFW VP Lauro Barajas (video/mp4 93.2mb)
Lauro Barajas, Vice President of the United Farm Workers....
Posted: Tue May 31, 2016 5:54PM
(video/quicktime 57.9mb)
Michael Garcia of the Watsonville Brown Berets...
Posted: Fri May 20, 2016 7:53PM
Leaving New Leaf (video/x-flv 14.4mb)
Posted: Tue May 3, 2016 9:47PM
"Boycott Driscoll's" Inside New Leaf Community Market (video/mp4 53.7mb)
[ Video: 00:26 ] On May 1, a large group of demonstrators, many of whom are also customers, entered New Leaf Community Market on Pacific Avenue in downtown S...
Posted: Tue May 3, 2016 12:59PM


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02 Mar 2017 4:49:12am
Where's the evidence??
Certainly didn't affect the Russian sub whose crew planted their flag under the north pole earlier this year.
Also from Paul Oberlander / Woods Hole Oceanographic Institution)
There was an eruption of assertions in recent days that the increasing summer retreats and thinning of Arctic Ocean sea ice might be a result not of atmospheric warming but instead all the heat from the recent discovered volcanoes peppering the Gakkel Ridge, one of the seams in the deep seabed at the top of the world.
Several experts said it was not plausible from the get-go, but for the sake of due diligence, I queried a heap of the Arctic oceanographers and climate and ice experts I've gotten to know since my North Pole journey in 2003. They uniformly reject the idea that heat from the bottom — either from the general geothermal activity beneath the seabed or the occasional outbursts of lava or vents — could have a significant impact on the veneer of floating, drifting ice on the surface.
The deep saltier, warmer water is largely isolated from the cold, fresher waters near the surface..."


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The story is familiar. Mary MacNamara, a young girl of 14 or so, is sexually abused by her father, James, a pathetic and manipulative man whose needy nature both attracts and repels the daughter who has become the centre of his craven universe. Following her mother's death from cancer, Mary becomes pregnant and runs away to England to get an abortion. She is brought back amid a dreadful blaze of publicity, made a ward of court and, refusing to implicate her father, forced to continue with the pregnancy. Politicians and lawyers discuss her case, as does the general public through the medium of radio phone-ins to which the hapless child, like the fox tossed about by the pack, listens in horror.
The book heaves with the imagery of corruption. An encounter with a ladybird, a creature prey to parasitic infestation, is a reminder that even closeness has its dangers: "I'll make a hole in your armour and then I'll eat you from inside," says Sister Aquinas at the convent which has become a kind of sanctuary to the child Mary.
This in turn reminds us of the cancer that is slowly and painfully destroying her mother, and is later echoed in the baby itself. An alien within, a creature of near horror, it is identified variously with the disease, with lies, and, grotesquely, with a malevolent suicidal fish forced upon Mary as a pet by the anti-abortion harpies who keep watch over the established pregnancy. "You wouldn't kill it, would you?" they wheedle. "Once you see a little soul struggling for life...". Mary sees only its "small black unfeeling bead" of an eye, the expression "one of spite". The implication clearly is of a deep rot at the very core of the society which spawned it.
What a joyless Ireland this is that we are shown. Nothing of the vigour and humour and richness of the place is allowed to intrude upon the pervading gloom.
Despite the modernity and distinctiveness of Edna O'Brien's voice, Down By The River is part of a particular mythologising vein that runs through Irish writing. It is there in the dense Joycean language ("O sun. O brazen egg-yolk albatross...") in the fine lyrical passages describing the hard, beautiful landscape, and in the characters themselves.
We are dealing with archetypes. Here the lonely Irish bard, there the chorus of wailing women. As for Mary - "She's every woman" in the words of a popular song that crops up more than once, and as such becomes so much a symbol that we lose her. Like the anonymous women we read about in the newspapers, we engage with her situation rather than her individuality. This, in fact, is precisely the point of the book. No-one in all the hubbub of conflicting voices sees the real human being at the centre of this nightmare, and neither do we. Mary is the invisible eye of the storm, the suffering innocent destroyed by bigotry, a very Irish archetype.
Ironically, we get to know her father far better. "A very heated man says a neighbour", but this is something of a euphemism. A terrifying mixture of weakness and brutality, James weeps with loneliness, rages at fate, depends like a baby on his wife and Mary, and blusters like the bully he is. His desperate yearning for his daughter is only surpassed by the bottomless pit of his own self-pity And because he is more real than Mary, it seems a strange injustice when we come to realise that he, in fact, is the tragic figure of the book. For Mary will survive - at the end her voice risen strong and true. The hidden blights - cancer, a baby - are nothing to the soul's own weakness, destroying from within.
- More about:
- Cancer
- Irish Politics
- Metals
- Mobile Phones


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Online Shop Launching in 2015
For those who can't join us in Millstreet or at the farmers market, Nibbles Online is the answer for our new range of:
- Homemade relishes, cordials and preserves
- Hampers of all sizes available
- Gluten free produce
The Nibbles Philosophy
The philosophy in Nibbles is to produce real food as nature intended, to capture the wholesomeness of home grown produce for both the plate and our preserves and to combine it with good quality locally sourced ingredients free from artificial preservatives.
This ethos, experience, skill and creative flair is blended with an unwavering interest in nutrition and good health, The award winning artisan café/bakery specializes in dietary restriction, in particular gluten, wheat, dairy, yeast and egg free produce. A dedicated gluten-free kitchen ensures the highest quality and safety standards.
Foraging for Natural Food
The concept of foraging for a wide range of natural food has become a global experience. That's because wild foods are rich in vitamins, minerals and trace elements – all vital ingredients in healthy and wholesome produce. Foraged ingredients are combined with organic home grown produce in a healthy alliance with local organic horticulturists and the 500 acre parkland.
Elderflower cordials and champagnes , Elderberry cordial the Irish equivalent to Echinacea, Meadowsweet & raspberry cordial, rose petal jam and rose-hip syrup, sit beside traditional fruit jams, home-grown beetroot relish or cucumber pickle. Many of the natural ingredients are growing in and around the 500 acre Millstreet Country Park where Nibbles second café, Nibbles in the Park, is based.
Nibbles in the Park
Wednesday to Friday, 11am till 6pm
- Hearty Vegetable Soup with Nibbles brown bread
- Selection of Cookies, Cakes & Treats
- Tea, Coffee & Hot Chocolates
Saturday & Sunday 11am till 6pm
- Full Café Menu
Sample the just baked goodness of our breads, hearty soups, tasty quiches and comforting casseroles, mouth-watering salads and wickedly indulgent desserts and treats.


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Bee Farm requires players to draw a route around the garden for their band of hard-working bees, gathering pollen from flowers and bringing it back to the hives. The garden is a dangerous place, so players must carefully and quickly help the five different types of bees to avoid carnivorous plants, wasp attacks, rain storms and tornados, all while making sure the busy workers don't crash into each other and lose their precious cargo. There is also a Survival mode that keeps the action going as long as the pollen is brought home.
The game is now available on App Store at a special offer price of $0.99 /€0.79 /£0.59 for iPhone, iPad and iPod touch, and at $2.99 /€2.39 /£1.79 for Mac.
Quick links:
App Store: http://itunes.apple.com/app/bee-farm/id426337143?mt=8
Mac App Store: http://itunes.apple.com/app/bee-farm/id426346172?mt=12
Trailer: http://www.youtube.com/watch?v=hjqywJINoIE
Vivid Games: http://www.vividgames.com
Przemyslaw Tkaczyk
PR Manager
Vivid Games
Mobile: +48.508.757.693
Phone: +48.52.321.57.28
Fax: +48.52.522.21.30
Slowackiego 1, 85008 Bydgoszcz, POLAND


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Fuchsia Revolution
Beastly Bijoux
Exploding with snarling attitude and mind blowing sparkle, Tarina's Beastly Bijoux introduces all new animal pave patterns that replicate the skin texture of dinosaurs, toads, and stingrays. Bolted-on solid steel claws and spikes ask the question… "Do you like playing with fire?" Each piece has the namesake of one of Tarina's favorite female rock idols. Wear at your own risk and take a dip in the danger zone!
Available now at tarinatarantino.com


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Home > Eyeglasses > Calvin Klein > CK5880 (213)
New Releases
Size and availability
Free outbound and return shipping
30-day money-back guarantee
Low prices
Free outbound and return shipping
30-day money-back guarantee
Low prices
CK5880/213 Eyewear
The term "visual aid" is unsuitable for CK5880. This is an accessory that ushers in a new you, emphasizing your clear view on fashion. The CK5880 is available in the Edel-Optics online shop in other styles from Calvin Klein collections 2015 and 2016.
This frame was specially designed for genuine power women. Graceful design and expressiveness are interspersed with classical chic. Full rim frames completely enclose the lenses within the frame. For a convinced eyeglass wearer, any other frame style is ruled out, with very few exceptions. Round eyeglasses are extremely prestigious. A fact John Lennon was aware of, being rarely seen without them. Harry Potter would also not be the same without his characteristic eyeglasses. Due to its shape the CK5880 will be a long-time companion, because round eyeglasses never really go out of fashion. Plastic frames like these combine durability and are comfortable to wear. The CK5880 is a very snug fit on the ears and nose. Brown is currently a trend colour and also an absolute timeless classic. The colour provides a nice contrast ratio between the skin and the colour of the eyeglass frame. Thus, the transition from eyeglasses to the face is harmonious and unobtrusive.
With the help of our digital dispensing optician, your prescription lenses can be configured according to your own requirements. Anti-reflective and cleaning coatings, antistatic and lotus effect are included as standard for plastic lenses.
Even if this Calvin Klein is presently not in stock, it is worth ordering now, because the current price can't be beaten. In our online shop we have consistently low prices. You won't get CK5880 at such a low price, not even in the sale.
New Releases
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Don't hesitate to call us at
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Few know that the "Highlander" movies were actually written, directed and acted by Baby Animals. Apart from being better than any human made movie; the series accurately depicts the everlasting struggle for immortality Baby Animals are in every day. This lion cub has just lost a duel to the death to a puppy with superior fighting skills. Fighting/Dueling skills are honed throughout the life of a Baby Animal for these moments of destiny.
VN:F [1.9.22_1171]"There Can Be Only One" Puppy vs Lion Cub,
More Cute Baby Animals:
Fatal error: Uncaught Exception: 12: REST API is deprecated for versions v2.1 and higher (12) thrown in /home/babyanim/public_html/wp-content/plugins/seo-facebook-comments/facebook/base_facebook.php on line 1273


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Is your resume in need of a little disruption?
Startups are all about
making things work better.
Our resume writing service is all about doing that for your CV.
StartUpHire is the place to find jobs at Short Hills startups. Review the list below of Short Hills startup jobs. These Short Hills, NJ jobs at start-ups represent some of the most rewarding careers available. You can refine your job search for Short Hills jobs by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options. Don't see the employment opportunity you're looking for? Check back soon for more startup jobs in Short Hills, or sign up for an email alert (link in upper left) to receive periodic updates on new start up jobs in Short Hills, NJ.
NEW YORKSALESFULL-TIME APPLY FOR THIS JOB This position is responsible for managing the day-to-day issues, questions, and training with the firm?s customer base. Serves as a ?client-advocate? within the firm and will drive revenue through ensuring a smooth-client experience and1/3/2017 New York, NY Save This Job
Marketing / Public Relations New York, NY, United States Apply Now About Gilt Gilt.com is an innovative online shopping destination offering its members special access to the most inspiring merchandise and experiences every day at insider prices. Gilt continually searches the1/3/2017 New York, NY Save This Job
Operations New York, NY, United States Apply Now Distribution Associate ? Gilt Groupe Gilt is looking for a full time Distribution Associate for our fast-paced team in NY. This position is temp-to-perm basis. We?re looking for a self-starter with attention to detail,1/3/2017 New York, NY Save This Job
Technology / Product Management New York, NY, United States Apply Now Director, Product Management The Director of Product Management has deep insights and expertise around a business vertical or subject matter. He/she will define Gilt?s product strategy in those areas and1/3/2017 New York, NY Save This Job
New York, NY - Full Time Job Description: We currently have an opening in the Sales department for an Account Coordinator. The ideal candidate will be an entry-level individual looking to grow their career within the digital media space and will thrive in a fun, fast-paced work1/1/2017 New York, NY Save This Job
It is a great time to be at TouchTunes! Our International expansion into Europe, the acquisition of Music Direction, expanding our services to include custom music programs for retail and hospitality businesses, the recent release of a major redesign of our mobile app and the1/1/2017 New York, NY Save This Job
SoundCloud is the world's leading audio platform, allowing everyone to share and discover unique content anywhere, anytime, on the web and on mobile. We are currently seeking a Programmatic Sales Manager to drive continued advertising sales growth for SoundCloud. You will use1/1/2017 New York, NY Save This Job
New York, NY About This Internship: The Design Intern will work closely with the Creative team to learn how to produce graphics that support the Music Marketing department?s promotions. Learning Opportunities: Learn to design and produce promotional materials including1/1/2017 New York, NY Save This Job
Responsible for meeting and exceeding the company's annual revenue and sales quota for assigned territory. Identifies, develops, and retains new business relationships via teleconferencing and Internet communications. Develops sales opportunities through prospecting, cold calling1/1/2017 Mountain Lakes, NJ Save This Job
Sales New York, New York Apply Description Category VP, Retail New York, NY xAd enables real-time, location-based marketing, without the guesswork. Working with xAd, marketers can deliver more relevant, personalized messages to the right people they want to reach, based on1/1/2017 New York, NY Save This Job
Brand Strategy - New York, NY - Full Time Director of Brand Strategy (New York) Woven Digital is one of the fastest-growing, privately held media companies in the country. We help brands speak to the digital generation by better understanding how they consume media. Our1/1/2017 New York, NY Save This Job
SoundCloud is the world?s leading audio platform, enabling everyone to discover creative music & audio content, connect with each other and share what they hear. We?re looking for a humble, technically confident Engineering Manager to help us build our Payments team which is1/1/2017 New York, NY Save This Job
Job Description Job Location: Remote (New York, Boston, Philadelphia, DC) Position Summary: The Sales Executive will be responsible for developing new business sales to build a pipeline, deliver a forecast, and overachieve on the assigned quota. This position will also be12/31/2016 New York, NY Save This Job
Location: New York, NYDepartment: ProductType: Full TimeMin. Experience: Experienced Qualifications: The Client Services Manager is accountable for the analytics solutions client delivery process and will drive implementation of projects and other initiatives following12/31/2016 New York, NY Save This Job
Cranford Worker Category :Part-time Regular Job Class Review patient records for current diagnosis, past medical history, precautions, and contraindications Adhere to all HIPAA regulations regarding patient confidentiality and recordkeeping Assist with scheduling of patient12/31/2016 Cranford, NJ Save This Job
Harrison, Harrison, NJ, US Worker Category :Full-time Regular Job Class SUMMARY: ? Perform responsibilities under general and direct supervision of the Director of Rehabilitation ? Provide therapeutic patient care based on current diagnosis and past medical history ? Assist12/31/2016 Harrison, NJ Save This Job
Harrison, Harrison, NJ, US Job Class SUMMARY: Perform responsibilities under general and direct supervision of the Chief Clinical Officer Provide therapeutic patient care based on current diagnosis and past medical history Manage the overall leadership and operation of the12/31/2016 Harrison, NJ Save This Job
Location: New York, NYDepartment: OperationsType: Full TimeMin. Experience: Experienced Summary: We are currently seeking a Project Manager with strong technical and organizational skills to work with internal team members and external vendors to manage the implementation of12/31/2016 New York, NY Save This Job
Location: New York, NYDepartment: BDType: Full TimeMin. Experience: Senior Manager/Supervisor Summary: The VP of BD leads all healthcare data sales efforts for assigned accounts, including market research, account sizing, & lead targeting, account planning, pipeline management,12/31/2016 New York, NY Save This Job
Intra-Cellular Therapies, Inc. (ITI) is an equal opportunity employer. Applicants may send their CV/resume and cover letter in plain text or as Microsoft Word attachments by e-mail to firstname.lastname@example.com/31/2016 New York, NY Save This Job


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Description from Ikea
Handmade shade; each shade is unique. Gives both directed and diffused light, good for lighting up a dining table.
- Ceiling cup: Polypropylene plastic
- Shade: Bamboo, Rattan, Clear lacquer
- Cover/ Shade holder: Steel, Pigmented powder coating
- Diameter: 29 cm
- Height: 41 cm
- Cord length: 1.8 m
Prices range from $69.00 to $149.00
$69.00 USD Buy from Ikea


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The HER centre supports women in crisis, who need advice and support, or seeking to learn and grow with other women. Make a positive change to their lives and help us continue our work, donate £5 now by texting
HERS11£5 to 70070
You can also donate
online securely at
Virgin Money Giving
please click the image below to visit our Virgin donation page.
Welcome to Her Centre.... Empowering women to move forward with their lives.
Established in 1997, Her Centre is a woman-led charity which supports over 1000 women a year who live, study or work in Greenwich. We offer free and confidential advocacy, counselling, outreach, advice and training in the following areas:
Advice & Outreach
Domestic Abuse and Sexual Abuse Advocacy
Young Women's Advocacy (13 – 19 years)
This printable flyer lists all our Her Centre & DV Services.
Her Centre Celebrates Living Wage Commitment.
The Living Wage Foundation is pleased to announce that Her Centre has been accredited as a Living Wage Employer.
The Living Wage Foundation Director, Sarah Vero said: "We are delighted to welcome Her Centre to the Living Wage movement as an accredited employer.
London Healthy Workplace Charter.
The Her Centre received the London Healthy Workplace Award.
Her Centre is one of over fifty organisations that have met the standards to date. The Healthy Workplace Charter is the first pan-London framework that supports and recognises investment in staff health and wellbeing. The charter has been set up by the Mayor of London to recognise and reward employers for investing in workplace health and wellbeing.
For more information please see our most recent Newsletter and find us on Facebook and Twitter.
We are a registered charity and a company limited by guarantee. As such, we are managed by a Board of Trustees, hold Annual General Meetings (AGMs) and produce an Annual Review and Annual Accounts that are public documents.
For hard copies of our Annual Accounts or Annual Review, or to enquire about our next AGM, please email us at email@example.com
Her Centre's Director Stacy Smith and Voluntary Worker Claire Platt were both interviewed by Greenwich Television and discussed about Her Centre's services.
Annual General Meeting: Change of Venue
We are pleased to invite you to the Annual General Meeting(AGM) of Her Centre, to be held on 22nd of February 2017, begining at 5.30pm at Woolwich Centre Gallery, SE18 6HQ.
Refreshments will be provided. In order to cater for the event, we would be grateful if you could indicate whether you are able to attend.
RSVP: Please respond by emailing email@example.com
We are generously funded by a variety of funders, including:


text:
Wego.com.sg recently found 948 hotels in Trogir, Croatia. Book last minute hotel or find great hotel deals such as Apartments Runac for S$183 per night. Save more on cheap hotels with rates from as low as S$32 per night.
Filters help you save time when choosing where to stay. Try clicking on a few now...
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Flights to Croatia Flights from Croatia Croatia Airports Croatia Airlines


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Maria, while I cannot imagine what it was like losing Ray, I am profoundly
sorry to hear about your loss. I can completely empathize with losing your
dog. I lost my eleven year old Boxer on February 1 and the sorrow I feel at
her death is indescribable. I cannot even begin to think what you must be
going through with your losses.
Please know that you are in our prayers, and we hope you will join in with
us when you can. As Ceres said so well, please try and remember to
celebrate your own life as you go through this time.
Andrea H
EarthLink Revolves Around You.
> [Original Message]
> From: Maria Olshin <email@example.com>
> To: <email@example.com>
> Date: 2/12/2005 6:15:10 PM
> Subject: Re: [CHAT] Happy Birthday Maria!
> Thenk you all for your kind remembrance. This has been the year from Hell
> for me. On January 8th, Ray, the love of my life, passed away and one week
> later, my dog died too. It can only get better (I hope).
> Maria in NE PA
> ---------------------------------------------------------------------
> To sign-off this list, send email to firstname.lastname@example.com with the
> message text UNSUBSCRIBE GARDENCHAT
To sign-off this list, send email to email@example.com with the
message text UNSUBSCRIBE GARDENCHAT


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President Muhammadu Buhari has just ratified the appointment of Elias Nwalem Mbam as chairman for the Revenue Mobilization, Allocation and Fiscal Commission.
President Buhari also ratified the appointment of Dr. (Mrs) Marilyn Amobi as the Managing Director/Chief Executive Officer of Nigerian Bulk Electricity Trading Company.
The appointment was contained in a press statement released by the Office of the Secretary to the Government of the Federation.
Read Also: Jonathan won the 2015 Presidential elections — Adamu Ciroma.
Elias Nwalem Mbam was on born 2 September 1958 in Nwofe-Agbaja, in Izzi Local Government Area of Ebonyi State, Nigeria.
He obtained his bachelor's degree in electrical engineering from University of Nigeria, Nsukka (UNN) in 1984 .
He had earlier on obtained an Associate's degree at Hartford State Technical College in the United States 1977 – 1979 .
He served as the Chairman of Enugu board for housing (1996-1998) and Chairman of the Ebonyi State board for housing (1996-1998).
He also served as Chairman of the Ebonyi Board lands (1998-1999).
Read Also: Chiukwu-okike-abiama asked me to restore Biafra — Director Kanu.
He was the commissioner of public works, land, housing and transport in Ebonyi (1999-2001) and Commissioner of Public Works and Transport in Ebonyi (2001-2005).
Dr. (Mrs) Marilyn Amobi will serve for four years.
Elias and Amobi are seasoned technocrats and are expected to the turn around the fortunes of both RMAFC and NBETC.


text:
I just installed the very latest Soundflowerbed version on my Macbook pro and I know it's installed because I can see the Soundflower outputs in my OSX audio setup. The problem is that when I go and reach the Soundflowerbed.app under the applications folder the little flower which is supposed to appear on the top right of the screen shows itself but only for one second or something, like if the app was crashing. So I can't access to the Soundflower settings. I uninstalled and reinstalled it 3 times but it didn't change anything to the problem and this is quite a problem for me cause I am trying to route the audio out of Traktor to Ableton Live and this is the best solution I found so far. Any suggestions about what would cause that problem ?
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text:
SKU: conf_Peg_Perego_Polaris_Outlaw
Your child will have a blast with the Peg Perego Polaris Outlaw. This ride-on toy is a 12-volt battery powered ride-on that has a two-speed gearshift of 2.5 and 5 mph, as well as a reverse mode. Parent's can also control speed with a gear lockout mode. Sturdy and durable, the kids- ride-on has high-traction knobby wheels for safe and comfortable driving on most surfaces. The Peg Perego Polaris Outlaw can hold up to 85 lbs. and is for ages 3 to 7 years old.
Features & Benefits:
- Fun Peg Perego Polaris Outlaw
- 12-volt battery powered ride-on
- 2-speed gearshift for speeds of 2.5 and 5 mph
- Gear lockout mode for speed control
- Reverse mode
- High-traction knobby wheels for safe and comfortable driving on most surfaces
- Sturdy and durable
- Rechargeable battery
- Charger included
- Made in the USA
- Can hold up to 85 lbs.
- Dimensions: 27.75"W x 29.5"H x 43.25"L
- For ages: 3 to 7 years


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Foster- Roger W. Attorney Clinton Oklahoma
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|Randolph S. Meacham P.C.
|Richard J Phillips Law Office
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text:
Logo for Ice Cream and Hot Dog Business
This project was awarded to crea8ivedesign for $89 USD.Get free quotes for a project like this
Project Budget$30 - $250 USD
Total Bids26
Project Description
The name of my Ice Cream and Hot Dog Business is going to be "Over The Top". We are putting crazy toppings on the hot dogs(part of the name is because the hot dogs are kinda crazy and "Over the Top" and you obviously put sprinkles and toppings over the ice cream. The ice cream is soft serve style and the hot dogs will have toppings like bacon, pineapple, guacamole, chili, coleslaw, etc, etc. Its going to have a "chipotle restaurant" type feel when you walk in and order.
It could be "Over The Top" with "Dips and Dogs" underneath with maybe something in the middle. Or maybe something more creative underneath or maybe just "Over The Top" and thats it. I don't want it to be cheesey(like with a hot dog dancing or something like that) . I would like it to be classy but hip as well
**********People that give "Mock-ups" will be given priority.**************** Hate to say that but last time I did something like this there were 3 people in the running and all 3 of them gave "Mock-ups".
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