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Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the United States with almost 5,000 attributable deaths per year. Despite significant advances in the understanding of the biology of CLL, it remains incurable and the cause of CLL is unknown. A more complete understanding of the biology of pre-emergent CLL will lead to novel prevention and treatment strategies. Monoclonal B cell lymphocytosis (MBL) is an asymptomatic hematologic syndrome characterized by small accumulations of clonal B lymphocytes in the peripheral blood. Most MBL share phenotypic characteristics with CLL: CD5+, CD19+, CD20dim, CD23+, and sIgdim. The biologic characteristics and clinical implications of MBL remain unclear. Our central hypothesis is that MBL are antigen-driven, post-germinal center CD5+ B cell expansions with variable potential for progression to CLL. To date, we have identified 73 MBL cases from 430 individuals ascertained from familial CLL kindreds both at Duke University and Genetic Epidemiology of CLL (GEC) consortium sites. In our preliminary investigations, we have found that MBL commonly have mutated immunoglobulin heavy chains (IgVH), express lower levels of surface IgM than CLL, and show enhanced B cell receptor (BCR) signaling when compared to memory B cells. To further explore these observations, three complementary specific aims are proposed: (i) to perform a detailed cellular and molecular biological analysis of MBL cases including single cell immunoglobulin gene analysis and detailed immunophenotyping;(ii) to explore BCR dependent signaling pathways in CLL and MBL and (iii) to follow a cohort of family-associated MBL subjects longitudinally to evaluate for evolution of the MBL clone, development of CLL, and other clinical outcomes. To investigate the biologic characteristics of MBL, we will perform detailed immunophenotyping and fluorescence-activated cell sorting (FACS) to purify MBL cells from MBL subjects identified through screening of Duke and GEC CLL families. We propose detailed evaluation of the B cell receptor to evaluate antigenic exposure and investigate whether receptor revision is a mechanism of by which IgVH unmutated MBL and CLL arises. BCR dependent signaling in MBL and CLL will be evaluated to determine the key mediators of the malignant phenotype in CLL;these signaling pathways will be targeted in vitro for CLL cell cytotoxicity. Finally, longitudinal evaluation to identify ongoing antigen refinement in MBL will clarify whether MBL are quiescent, good risk CLL or if MBL are dynamic populations that acquire additional somatic mutations as part of a step-wise transformation to CLL. In summary, MBL provides an important window into the biology of pre-emergent CLL. Careful investigation of subjects with MBL will illuminate the transforming events that lead to CLL, the role of antigenic stimulation in early CLL leukemogenesis, the signaling pathways that favor disease progression, and allow for MBL risk stratification for development of CLL.
Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the United States, with approximately 90,000 affected individuals and 4,500 attributable deaths per year. Monoclonal B lymphocytosis is an identified precursor state for CLL, and is approximately 100 times more prevalent than CLL. The experiments described herein will clarify the biology of pre-emergent CLL, discover the determinants of progression from MBL to CLL, and identify novel targets for therapeutic intervention in CLL.
|Friedman, Daphne R; Lanasa, Mark C; Davis, Patricia H et al. (2014) Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial and in vitro studies. Leuk Lymphoma 55:1067-75
|DiLillo, D J; Weinberg, J B; Yoshizaki, A et al. (2013) Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. Leukemia 27:170-82
|Hebbring, Scott J; Slager, Susan L; Epperla, Narendranath et al. (2013) Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. Blood 121:237-8
|Slager, Susan L; Achenbach, Sara J; Asmann, Yan W et al. (2013) Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes. Cancer Epidemiol Biomarkers Prev 22:461-6


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Avoid Being a Roman Soldier
€ 8,49
Lieferbar innert 2 Wochen
Juli 2006
BeschreibungFeatures cartoon-style illustrations and narrative approach, aiding readers' understanding of what life would have been like being a Roman Soldier. This work fits into KS2 History, and is a useful text for shared and guided reading for KS2 pupils. It helps achieve the goals of the Scottish Standard Curriculum 5-14.
PortraitDavid Antram was born in Brighton in 1958. He studied at Eastbourne College of Art and then worked in advertising for 15 years before becoming a full-time artist. He has illustrated many children's non-fiction books.
Untertitel: 'The Danger Zone'. New ed. colour illustrations. Sprache: Englisch.
Verlag: Salariya Book Company Ltd
Erscheinungsdatum: Juli 2006
Seitenanzahl: 32 Seiten
Format: kartoniert
Alle Preise inkl. MwSt., ggf. zzgl. Versandkosten

subset: commoncrawl


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Louanne Chan
Executive firstname.lastname@example.com
Louanne joined Reel Asian in 2009 as a volunteer on the Special Events Committee. Since then, she has taken on the staff roles of Director of Marketing, Managing Director and currently oversees the festival's sponsorships, grants and finance as the Executive Director. Prior to Reel Asian, Louanne worked in the business development department at Ronald McDonald House Charities Toronto and taught English in Taiwan. Louanne holds a Bachelor of Commerce degree with a specialization in International Business and East Asia from McGill University. Louanne enjoys Stephen Chow comedies, anything with Daniel Wu and can be seen cycling around the city with her Totoro backpack on.
Kristine Estorninos
Head of email@example.com
Kristine Estorninos has been a festival distribution strategist for over five years. Before arriving in Canada, she worked in feature film production and distribution in the Philippines. She worked in film distribution at the Canadian Film Centre, as well as at Ouat Media, where festival strategy was key to earning the company's films numerous Oscar nominations and wins. Kristine has curated and juried for local and international film festivals, and has been involved with Reel Asian over the years in numerous capacities including special events and programming. She holds masterclasses and presentations about film festival strategy and distribution at various institutions and festivals around the world. To find her at any event, search for the small girl holding up a burger the size of her head.
Chris Chin
Festival & Operations firstname.lastname@example.com
Chris Chin is going into his twelfth festival with Reel Asian, having started out as a Front-of-House volunteer back in 2003. He is an Associate Programmer at the Inside Out Toronto LGBT Film Festival and has worked and volunteered at other festivals including the Toronto International Film Festival, Images Festival, Calgary International Film Festival, and Frameline San Francisco International LGBT Film Festival. In addition to his festival commitments, he has provided event management and operations support to organizations including the Center for Asian American Media (SF), Pride Toronto, and the Canadian Film Centre. Chris sings with choir!choir!choir! and is always up for a night of karaoke.
Aram Collier
Programming & Education email@example.com
Aram Siu Wai Collier is a San Francisco native and has a BFA and MFA in Film Production from the University of California at Santa Cruz and York University respectively. He has been involved with Reel Asian since 2005 in numerous capacities specializing in programming, industry and commissioning projects. Aram has also worked or volunteered at the Toronto International Film Festival, Hot Docs, and ImagineNative. He has a background in documentary post production, editing a pair of documentaries broadcast nationally in the United States. His own work has played festivals in the United States, Canada, Japan and China. In the summer time Aram can be found barking orders to his two softball teams.
Philbert Lui
Marketing email@example.com
Philbert has been involved with Reel Asian since 2010. He has worn several hats at the festival as the Marketing Committee Co-chair, Assistant to Volunteer Coordinator, and the Volunteer Coordinator. In the past Philbert has worked with the Sony Centre for the Performing Arts, Kollaboration Toronto, and the Canadian Film Centre. He completed his Bachelor of Arts at York University where he studied Film and Communication Studies. Philbert is also a recent graduate of Seneca College's Social Media Program. Outside of the festival, he deep dives into manga, comic books, basketball, stop-motion animation, and many other geeky pursuits. #WeTheNorth!
Betty Xie
Development & International Programming email@example.com
With a background in Cinema Studies and Asia Pacific Studies, Betty started working for Reel Asian in 2013 as the festival's VIP Guest Service Assistant. Currently, she manages the festival's membership program and helps to program Chinese language films. When she is not busy working at Reel Asian, she is also an independent filmmaker, making both fiction and documentary films. Her most recent film The Home Promised has traveled to film festivals around the world. Find Betty at the member line-up during the festival, and chat with her about film, food and horoscope.
Milica Dodic
Programming & Events email@example.com
Mili Dodic has been working in the film industry for over 4 years, ranging from festival and awards work to film distribution. She has worked with many Canadian film organizations and companies, including Ouat Media, Mongrel Media, and the Academy of Canadian Cinema and Television. Her education and love for Asian cinema and culture has led to her involvement with the Toronto Reel Asian Film Festival as a special event captain for 3 years, before taking on the role of Event Coordinator, and subsequently Programming Coordinator. Her passion for food and languages (she speaks English, French, and Serbian fluently, with some conversational Korean) has definitely translated over to her success in the festival's community. In her time outside of the festival, she can be found doing the exact same things: watching countless pan-Asian films (and K-dramas), exploring delicious cuisines, and being a hostess with the mostess, with an added nail art business.
Amanda Clarke
Volunteer email@example.com
Amanda has been involved in the Toronto film scene since 2011. She holds a BSc from the University of Toronto in Cinema Studies and Human Biology and is currently working towards her MA in Cinema Studied from York University. Amanda began volunteering with TIFF and since then has been involved with most of the major film and performance festivals in the city as both a volunteer and staff including Hot Docs, Reel Asian, Images, Luminato and The Toronto Fringe Festival. She is the former volunteer coordinator for Planet in Focus Environmental Film Festival and is excited to be working with Reel Asian's awesome crew of volunteers this year. When not working the festival circuit, she is most likely hanging out on the ice, regardless of the season.
Stephanie Law
Education firstname.lastname@example.com
Stephanie has been involved with Reel Asian since 2011 when her short film, Little Miss Jihad, won the festival's 'So You Think You Can Pitch?' competition (emerging category). Since then, she has held various roles at the festival, coordinating Development, Special Events, Industry Series, Pitch Competition, and Youth Outreach. Stephanie holds a B.F.A. Honours in Film Production and Screenwriting from York University, and has worked for Women in Film and Television – Toronto, Toronto International Film Festival, and several Toronto-based film production companies. She is currently developing several film projects and scripts of her own.
Ammar Keshodia
Industry Events firstname.lastname@example.com
Ammar Keshodia is a British-born Pakistani-Canadian filmmaker. He graduated from the University of Toronto in 2014 with a degree in Political Science and Cinema Studies. Ammar was part of the 2015 class of the Unsung Voices summer video production program where he wrote and directed Ayano In The Forest, which premiered at the 2015 Reel Asian Film Festival. This year he served as a member of the short films programming committee for TIFF 2016, in addition to running the Unsung Voices Programme during the summer.
Gina Rim
Accreditation email@example.com
Gina has been with Reel Asian from 2008 initially as a volunteer then as a Volunteer Coordinator for the next 5 years. She
has been involved as a member of the programming committee since then and has joined Reel Asian this year as the
Accreditation Coordinator. In addition to Reel Asian, she worked and volunteered at other festivals including TIFF, Toronto After Dark Film Festival and Luminato. She is also an experienced interpreter and translator with Reel Asian, Hot Docs and Images Festival. Gina has found joy in parenting by dressing up her toddler daughter in different costumes and going on walks to catch Pokemon.
Rebecca Hong
Marketing firstname.lastname@example.com
Rebecca is currently in her fourth year studying Arts Managementat the University of Toronto Scarborough. Rebecca has been involved in the arts since she was a young teen and has previously worked/volunteered for several arts organizations including Wavelength Music Series, Art Gallery of Ontario, Harbourfront Centre, and Long Winter. She first started her involvement at Reel Asian in 2015 as the Marketing and Festival Intern and is excited to be back again for the 20th anniversary of Reel Asian. Rebecca supports the marketing team with graphic design, social media, and communications. Outside of school and work, you can find Rebecca at local shows, at the park, or in an art gallery.
Ankita Sharma
Marketing firstname.lastname@example.com
This is Ankita's first year with Reel Asian. She is one of the Marketing Interns and is also part of the festival's Marketing Committee as the South Asian Community Ambassador. Ankita is in her thesis year at the Ontario College of Arts and Design University for Integrated Media (BFA). As a practising artist she creates documentaries exploring themes of personal experience, human relationships and conversations. She is currently working to publish a collection of poems with an addiction of travelling and coffee.


text: Kris Kardashian Holds Bruce Jenner's Purse StringsTracie Egan Morrissey1/04/10 11:00amFiled to: family affairsKeeping up with the kardashians moneyKeeping Up With The KardashiansKris KardashianRob kardashianKourtney KardashianClipsbruce jennerTop692EditPromoteShare to KinjaToggle Conversation toolsGo to permalinkLast night's Keeping Up with the Kardashians showed that Kris handles all the finances and keeps her husband Bruce on a strict allowance, while she spends money freely. Of all the B.S. storylines on the show, this one seems real. Speaking of B.S., this subplot of Rob trying to win ex-girlfriend Adrienne Bailon back is edited to seem like she cheated on him. However in (the real) reality, it was the other way around. Lastly, Khloe is still the most entertaining of the whole group.Reply69 repliesLeave a reply


text:
Acute inflammation is a normal immune response to bacteria, viruses or injuries. Characterized by heat, redness, swelling, pain or loss of function, acute inflammation lasts for days or weeks at most, and is a healthy response to help our bodies become stronger. This is particularly true for those who exercise to improve health, as some degree of inflammation is necessary to help your body rebuild tissues and increase strength and stamina to prepare for future demands.
As we age, inflammation levels tend to rise. Instead of a few days of pain and discomfort, inflammation becomes chronic. The symptoms are more mild, yet continued stress to the immune system disrupts our natural defense mechanisms and can damage otherwise healthy tissues. Chronic inflammation, caused by smoking, pollution, inactivity, sleep deprivation, stress and poor nutrition, is at the root of many modern diseases.
Preventing Age-Related Inflammation with Exercise
Research continues to suggest that regular exercise is associated with lower levels of inflammation and may be the key to moderating chronic inflammation caused by age and lifestyle factors. In a study published by the American Heart Association's Circulation journal, over 4,000 men and women at the average age of 49 were studied over a 10-year period to determine the relationship between physical activity and inflammation. From the outset, physically active participants showed lower markers of inflammation, and the results remained stable over time. At the end of the study, 49% of participants adhered to at least 2.5 hours per week of moderate to vigorous activity and were able to maintain lower levels of inflammation than their less active counterparts. No matter what age you start exercising, regular physical activity may play an important role in preventing the onset of inflammation as you age.
Reducing Chronic Inflammation with Weight Training
If weight training briefly increases acute inflammation (the stiffness and sore muscles you experience after a tough workout), what happens to chronic inflammation? A University study published in the Medicine & Science in Sports & Exercise journal found that weight training reduced markers of inflammation in obese, postmenopausal women, in the absence of changes in body composition. The subjects had not participated in any exercise 6 months prior to the study, and were not smoking, taking hormone replacements, or affected with any immune or metabolic disorders. For their age and BMI, study participants could be considered very healthy. After a 12-week weight training program, participants not only reduced their levels of chronic inflammation, their bodies were better able to respond to periods of acute inflammation. Aerobic exercise is frequently prescribed to reduce the risk of disease, however, weight training may be key to unlocking the anti-inflammatory benefits of regular exercise.
The Positive Effects of Exercise Go Beyond Weight Loss
The positive effects of physical activity and exercise are hard to ignore. Not only is it a means to combat many health conditions and diseases, regular exercise has been shown to have a measurable impact on improving the body's response to both acute and chronic inflammation. People who are regularly active sleep better, are more social, and experience a greater zest for life. Regardless of whether you lose weight, the positive effects that come with regular exercise are crucial to maintaining quality of life as you age.
Sarah Dalton is the founder of Able Mind Able Body, a Las Vegas based company offering motivational lifestyle coaching and personal training services. She takes a holistic approach to healthy living, and educates others on the benefits of nutrition, exercise, and emotional health. Visit www.ablemindablebody.com for more info.


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Ticket sales automation
This project received 5 bids from talented freelancers with an average bid price of $346 USD.Get free quotes for a project like this
Project Budget$30 - $250 USD
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Project Description
In this project, you are asked to create a ticket sales automation that a long-distance ticket-sales company can use. This project is basically intended for you to use filing and achieve graphics use in the programming language C.
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don't know about NC.... but here in Illinois it is gorgeous this year.
> We live in Williamsburg, VA and nothing is happening here yet with fall
> color. How about the rest of you? We are supposed to go to Asheville, NC
> this weekend and I wondered if any of you live out in the Smokey's and have
> you had any fall color yet? Verona
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Be the first to like this
Published on
Spot Instances are a new way to purchase and consume Amazon EC2 Instances.
They allow customers to bid on unused Amazon EC2 capacity and run those instances for as long as their bid exceeds the current Spot Price.
Value to the customer
Up to 92% discount off of On-Demand Instance
Only need to commit to 1 hour
Trade off
Potential for interruption
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text:
Glume despre farmacii
Explorează subiecte asemănătoare
I need to print this and play at my pharmacy! I don't think it would take long to get a Bingo!
Pharmacy humor. I know & love people in the pharm business. This is for them, and they know who they are!
I'm laughing way harder than I should.
I'm am seriously asked this all the time... really people? Do I look like I work at the drs office?
I'll fax this to your pharmacy. They'll have it ready in 15 mins, because you are their only customer and they are standing around waiting for.
So funny & so true!
This man needs a med rec, not a refill.
Pharmacy humor - I don't always call insurance companies, but when I do, I keep saying "Representative" or hitting random numbers until I can talk to someone.
Never expected this or "Where is/Do you have a restroom?" to be the most commonly asked questions to the pharmacy ...
Funny pharmacy sayings


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Trade Assurance:
Product quality protection
On-time shipment protection
Payment protection
Home > Company Profile
Shenzhen Starfly Technology Co., Ltd.
Start Order
Onsite Check
The supplier's company premises has been checked by Alibaba.com staff to ensure onsite operations exist there. A third-party verification company has confirmed the legal status of the supplier.
|Business Type:
|Manufacturer, Trading Company
|Guangdong, China (Mainland)
|Main Products:
|tablet pc,mobile phone,tablet pc case,phone case,accessory
|Total Employees:
|101 - 200 People
|Total Annual Revenue:
|Above US$100 Million
|Year Established:
|Top 3 Markets:
|South America 25.00% Central America 15.00% Western Europe 15.00%
Shenzhen Starfly Technology Co., Ltd. is a professional manufacturer of telecommunication products a...
Shenzhen Starfly Technology Co., Ltd. is a professional manufacturer of telecommunication products and digital products in China, established in 2007 and located in Shenzhen.
Our company has many professional engineers, software designers, electronic engineers and skillful workers, as well as advanced equipment. We can provide excellent quality products with the characteristics of stable performance and beautiful appearance, and we can deliver goods promptly. Therefore our products are warmly welcomed by clients in overseas markets and have sold well in many countries and regions, such as Europe, America and Australia.
Following the management aim of "Quality First, Efficiency First, Credit First and Service First", we are devoted to the non-stop development and innovation of products, with the availability of excellent products and services for our clients.
We welcome customers to cooperate with us. We are willing to cooperate hand in hand with our clients to obtain a win-win result for both sides
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Trade & Market
|Main Markets
|Total Revenue(%)
|South America
|Central America
|Western Europe
|Northern Europe
|Eastern Europe
|North America
|Southern Europe
|Southeast Asia
|Export Percentage:
|91% - 100%
|No. of Employees in Trade Department:
|6-10 People
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Hotel Masaccio
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Hotel Masaccio Hotel Details
Check-in: noon
Check-out: 11 AM
Discover all that San Giovanni Valdarno has to offer with Hotel Masaccio as a base.
The Hotel Masaccio boasts a convenient location with modern amenities in every guestroom and superb service.
Each guestroom has air conditioning, desk, daily newspaper.
Services and amenities available for guests at this San Giovanni Valdarno accommodation consist of meeting facilities, 24hr room service, laundry service/dry cleaning.
This hotel is characterized by a combination of modern comfort and traditional element of San Giovanni Valdarno, making it a distinct accommodation.
To make your reservation at the Hotel Masaccio quick and easy, please select your preferred dates of stay and proceed with our secure online booking form.


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DuWop Private Nude is a colour changing lipstick that morphs to each woman's personal nude shade. Adapting to your unique chemistry and adjusting accordingly this lipstick takes the hassle out of selecting the perfect shade.DuWop Private Nude's proprietary formula includes a blend of three naturally derived pigments and the technology behind the classic 'mood lipsticks' of the seventies to provide a vibrant shade that adapts to suit each individual's colouring. The silky lipstick goes on smooth and the rich pigment changes within five minutes to leave behind the perfect nude hue for every wearer.Check stock and price
Duwop Private Nude
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'Duwop Private Nude' is from the Cosmetics category
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Black Eyed Susan by Suzanne Bryan
Welcome! You are browsing as a guestWould you like to see 3 projects made from this pattern and much more? join Ravelry now What am I missing?
© Suzanne Bryan
Black Eyed Susan
This is one of the two pillows associated with the Summer 2014 Cast On Magazine, Intarsia Stitch Anatomy Article.
For more information, see: http://www.tkga.com


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On Wednesday, in its new World Economic Outlook [WEO], the International Monetary Fund [IMF] announced that global economic growth is slowing.
The WEO advised that:
The global expansion is losing speed in the face of a major financial crisis.The report says that, thanks to the correction in the housing market, the leading offender is the U.S.
The emerging and developing economies have so far been less affected by financial market turbulence and have continued to grow at a rapid pace, led by China and India, although activity is beginning to moderate in some countries.
How bad will it get? Judging by the IMF's estimates, the outlook is more about a slowdown rather than an outright contraction. According to the IMF, last year, global GDP rose by 4.9%. The projection for 2008 is 3.7% growth, followed by 3.8% in 2009.
If the prediction proves accurate, the deceleration will still bring pain to various segments of the world economy. Then again, world GDP rising by 3.7% is hardly a disaster. Indeed, 3.7% growth is the upper range that's prevailed since 1970, as the chart below shows.
But no one should ignore the other risks bubbling that aren't obvious in estimates for GDP. Inflation remains a threat, for example, particularly in the developing world (see chart below). The trend threatens the ability of the developing world to export disinflation to the U.S. and the developed world generally, as has been the case in past years. At some point, if prices keep rising, might the emerging markets export inflation? In fact, that seems to be the case now for certain items, starting with oil, which on Wednesday touched another new record high of $112 a barrel in New York. The U.S. is the world's biggest consumer of oil, and more than half of its crude is imported, much of it from the developing world.
Meanwhile, monetary policy threatens to fan inflation's fire. According to the IMF, real short-term interest rates have turned negative in the U.S., Europe and Japan, as the third chart below shows.
Of course, the argument for such a loose monetary policy is that the global economy needs an antidote to the deleveraging that's sweeping financial systems from New York to London to Tokyo. The IMF report warns that:
A further broad erosion of financial capital in a climate of uncertainty and caution could cause the present credit squeeze to mutate into a full-blown credit crunch, an event in which the supply of financing is severely constrained across the system.
In fact, one could argue that a fair degree of the global economy's future path over the next year or so is tied to whether or not the credit crunch mutates into something worse from this point onward. The challenge for policy makers is that addressing each scenario requires different medicine. If greater liquidity troubles are coming, central banks may feel compelled to act by effectively printing more money than is otherwise prudent. The danger is that the liquidity injections turn out to be unnecessary, in which case inflationary pressures will be that much more troublesome and difficult to control. If, and when that becomes the leading issue for central banks, the easy money party will end, perhaps for an extended period.
The IMF report leans toward the conclusion that the credit crunch may yet get worse before it gets better. Unfortunately, no one really knows and so the risk of dispensing the wrong policy medicine remains higher than usual at the moment. Risk, in short, is still with us even if the world economy is set for modest growth.


text: Vanessa Williams Sings a GoodbyeLauri Apple1/22/11 7:50pmFiled to: Snap JudgmentVanessa williams sings r. sargent shriver funeralrippeace corpsAppicR. sargent shriver funeralkennedysShrivers13EditPromoteShare to KinjaToggle Conversation toolsGo to permalink [Potomac, Maryland, January 22: Vanessa Williams sings a song during the funeral mass for R. Sargent Shriver—the first director of the Peace Corps—at Our Lady of Mercy Catholic church. Image via AP.]Reply13 repliesLeave a reply


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Miguel is a fan and he's worked with Banks, SZA, and Lana Del Rey—it's high time you familiarized yourself with this London electronic artist. Plus here's the premiere his 4AD session of "The Wheel."
SOHN's personality is exactly what you'd expect after listening to his debut record Tremors—a nihilistic compendium set to airy synths and slow-motion bass. In conversation, the Vienna-based producer speaks in a measured whisper and comes across as thoughtful and even poetic. But SOHN's idea of poetry might not appeal to everyone. While unpacking the song "Paralysed" on his album, the artist uses the word "beautiful" to describe a set of lyrics about feeling like someone could slit your throat and leave you on the side of the road. To him, that's a metaphor for being in love. There are a lot of similar moments of what SOHN refers to as "positive nihilism" on the rest of the record.
"The Wheel," the live video premiering above, opens with the line "I died a week ago" which, according to SOHN, should be interpreted as a statement of freedom, not literally. If Nietzsche made electronic music he would have produced Tremors. We phoned SOHN while he was on break in Vienna to talk about working with Miguel, Banks, and SZA, being a recluse, and accepting that we're just specks of dust within the grand scheme of things.
Noisey: How long ago did you start experimenting with this pacing and sound?
SOHN: About two years ago. I have a friend, in the live band, who collects antique analog synths. Getting a chance to play with those made the music happen. Before I was making music on computers and making stuff with the software.
What was your musical background prior to that?
I've been knocking around, trying things and not doing them very well [laughs]. I learned guitar when I was a kid and was into some terrible rock music. When I was 12 I got into indie music and liked things like Björk, Radiohead. I ended up doing electronic music almost by accident. I want to hear [a] song, not a technical exercise. I ended up making music that uses the electronic palette just because I love using these instruments. I'm very much an outsider.
It's funny that you say that because you're from London and left just as this new wave of slower, brooding electronic artists started bubbling up. Were you thinking of distancing yourself when you've left?
I've just always been that way. I'm a solitary person and didn't get involved in any of that stuff. I was offered an opportunity [to] move, so I did. I'm a European citizen and can live anywhere in Europe. It was probably a reaction to not being involved with anything in London. But I've come to realize that has nothing to do with London—it's just me. I'm not the type of person who lets myself get involved.
I don't know if you've heard about a recent fist fight that broke out between Hudson Mohawke and Zomby… [Read all about that here]
I've heard.
What was your take on that?
I don't know either of them. I saw it happening on Twitter and it's just a bit of nonsense, isn't it? I don't really understand what that's all about.
It seems kind of antithetical to their music.
Yeah, but I know that one of those people has got a bit of a history with that stuff as far as I've been told [laughs]. That's so far away from me. That's in the UK club stuff which I've never, ever been involved with. You know those youth [laughs].
I have an idea of who you're talking about. You shared a label with him.
[Laughs] I couldn't possibly comment because I don't want to get beaten up.
So has working in Vienna shaped your sound?
It really has. The pace is a lot slower. It enables you to [have] the space and room to explore. England is the same communication speed as New York and Los Angeles. In a place like Vienna, that's just not there. [It's] very laid back and that makes its way into the music.
What kind of mindset were you in when you were writing the album?
Melancholy is one of my main threads. There are moments of positivity but they come out in a very macabre way because of the instinct I have as a writer. A song like "The Wheel," where it starts with "I died a week ago." It's dramatic and dark but to me that's an incredibly positive statement. You can start again. It's rebirth and freedom. It's positive nihilism. That feeling that everything is pointless and worthless and nothing means anything and that's something to rejoice because there's no right or wrong answers and you can do whatever you want.
What are some of the other positive moments on the album?
Probably some of the lyrics which are the darkest lyrics actually. There's a song called "Paralysed" where it sort of ends—[laughs] I'm just realizing I'm trying to tell you this is positive and the lyrics are—"Nobody can slit my throat/ Nobody can leave me laying by the side of the road like you can," which is a graphic image of being in love. It's like putting your life in someone's hands to the point where they can slit your throat metaphorically. But it's a beautiful thing.
So your idea of positivity is like two negatives canceling each other out.
Yeah, I would say so. I see that release of negativity to be positive.
I'm curious about the story behind "Ransom Notes."
It's a very philosophical song. It's an observation on the fact that you're tiny. Us human beings think the most important thing is that Monday meeting or that person we're in love with, whatever. There are mountains on this planet which have moved in such a long period of time and we wouldn't even see them moving because we're tiny, tiny piece of time compared to the earth, let alone the universe. Mountains manipulate themselves and move because the continents separate and that happens over a longer period of time than the whole of human existence. That's mind blowing.
You've collaborated with Lana Del Rey and Banks. When you choose your collaborations, do you try to align yourself with people who have a similar aesthetic?
No. Normally it just comes from hearing something and thinking, "I know what I could do with that." If I have that instinct, generally I jump on it.
Banks has a similar sparse singing style.
Part of that comes from the fact that I constructed one of her early songs and Teebs constructed one. We're like-minded artists so it's natural we've ended up in the same realm. I'm probably now doing a bit more further out of that realm. I've got productions but I don't know what's going to come out. I did something with SZA and I don't know if that's going to come out. I spent a couple of days with Mø recently in Copenhagen and I don't know what will happen because her album has just come out. I've probably got a couple more Banks tracks coming.
Have you been approached by any more mainstream artists to write for them?
I have been by a few and it's an interesting place to get because word has gone around the industry. It's difficult to know because songwriting is so different from collaborating and production. It's something I'm interested in getting into because I want good songs in the world. If I can write a good song for someone, even if they're a massive star, there will be another good song out there.
What was your reaction when you found out that Miguel is a fan?
It was cool. I've met him and he's a really, really nice guy. I don't know if we'll get in the studio. That could happen. It's funny because it's so bizarre to me that these people even know who I am. I'm just this guy who's living on the Eastern edge of Western Europe, making some stuff in a studio.
Tremors is out on 4AD on 4.7
Meet Mø: Denmark's Diplo-approved popstar with a crust punk past.
Watch SZA's Video for "Ice Moon," Plus an Extensive Interview
Meet BANKS: She Knows How to Turn Heartbreak into Greatness ...
SOHN Tour Dates
5/7 - Rock & Roll Hotel, Washington, DC, US
5/8 - Johnny Brenda's, Philadelphia PA, US
5/9 - Bowery Ballroom, New York, NY, US
5/10 - Rough Trade, Brooklyn, NY, US
5/12 - The Sinclair, Boston, MA, US
5/13 - Ill Motore, Montreal, QC, Canada
5/14 - Horseshoe Tavern, Toronto, ON, Canada
5/15 - The Pike Room, Detroit, MI, US
5/16 - Bottom Lounge, Chicago, IL, US
5/17 - 7th St Entry, Minneapolis, MN, US
5/20 - Fortune Sound Club, Vancouver, BC, Canada
5/21 - The Crocodile, Seattle, WA, US
5/22 - Holocene, Portland, OR, US
5/24 - Independent, San Francisco, CA, US
5/25 - The Casbah, San Diego, CA, US
5/27 - Troubadour, Los Angeles, CA, US
5/31 - Maifeld Derby Festival, Mannheim, Germany
4/4 - Rockhouse, Salzburg, Austria
4/5 - Conrad Sohm, Dornbirn, Austria
4/8 - Gebaude 9, Cologne, Germany
4/9 - Exit 07, Luxembourg
4/11 - Uebel & Gefahrlich, Hamburg, Germany
4/12 - Lagerhalle, Osnabruck, Germany
4/13 - Heimathafen, Berlin, Germany
4/14 - AB Club, Brussels, Belgium
4/16 - Melkweg, Amsterdam, Holland
4/17 - Village Underground, London, UK
4/19 - Nouveau Casino, Paris, France
4/20 - Zoom, Frankfurt, Germany
4/21 - Papiersaal, Zurich, Switzerland
4/23 - Arena, Vienna, Austria
4/24 - Hiroshima Mon Amour, Turin, Italy
6/7 - Field Day, London, UK
7/18 - Latitude Festival, Henham Park, Southwold, Suffolk, UK
Marissa is a writes about music all day every day and she's on Twitter - @marissagmuller.


text:
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text:
Elephant Ears
|Crescent roll dough
|1 Can (10 oz)
|Margarine stick
|1 1⁄4 Cup (20 tbs)
|3 Teaspoon
|Egg yolk
|1 Teaspoon
Butter two foil-lined cookie sheets.
Mix sugar and cinnamon.
Melt margarine.
Separate roll dough into 2 oblongs, pressing perforations to seal.
Spread with margarine and sprinkle with a little sugar and cinnamon.
Starting at the long side, roll up as for a jelly roll.
Cut each into 12 slices.
Dip each into melted margarine, sugar and cinnamon.
Place cut side down on tin, pressing with the palm until very thin.
Brush with egg yolk mix and top with remaining sugar and cinnamon.
Bake at 350° for 10 minutes.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 2846 Calories from Fat 1192
% Daily Value*
Total Fat 132 g203.5%
Saturated Fat 27.2 g136.1%
Trans Fat 0 g
Cholesterol 185.1 mg61.7%
Sodium 2985.5 mg124.4%
Total Carbohydrates 409 g136.3%
Dietary Fiber 8 g31.9%
Sugars 250.2 g
Protein 17 g34.3%
Vitamin A 90.4% Vitamin C 1.9%
Calcium 26% Iron 47.8%
*Based on a 2000 Calorie diet


text:
Early 1960s "Treasure from California" by Faris Lilac Nylon & Ruffle Pin-Up Panties
$ 18.00
Channel your inner bombshell, pin-up or sex kitten in these cheeky high-waisted panties!
Fashioned in 100% nylon, these little cuties feature delicate ivory lace detailing with 3 petite ribbon florets on the front.
Panties have waist.
Waist: 18" - 30"
Hips: 36" - 41"
Size: Marked size 6
Label: "Treasure" from California by Faris
Condition: Very Good
Elastic is in great shape. There is one small tear in the nylon at the waistband and a number of small snags throughout, which is not uncommon in nylon. There also is a small tear in the lace on one of the legs. Still very wearable and would be great for burlesque or a photo shoot. Priced accordingly.
Please view our Condition Chart for additional information.
See more: 1960s


text:
In the 1980's FRANK BELLO was the hit-making arranger, pianist and musical director for Hansel & Raul, Luis Enrique and Roberto Torres. Originally forming the band to back up those artists, he went on to provide accompaniment when artists as diverse as Ismael Miranda, Raul Marrero, Hugo Henriquez and Vicentico Valdez, among others, performed in South Florida. There were also two very successful and...
Copyright © 2001-2017 OneWed Inc.
All Rights Reserved.
Copyright © 2001-2017 OneWed Inc. All Rights Reserved.


text: >>> Stefano Sabatini <stefano.sabatini-lala@...> seems to think that: >Hi, as in subject, also add some documentation to >semantic/doc/glossary.texi, but maybe this needs more editing from a >more competent hand (I wrote it a long time ago), so if you prefer I >can send you another patch with only the typo fixes. > >Thanks again for cedet, regards. [ ... ] Thanks for the patch. I've applied it to my local copy, and will check in the doc ones after I finish off the edits I had been working on in those same files. I checked in the others. -- Eric Ludlam: eric@... Siege: http://www.siege-engine.com Emacs: http://cedet.sourceforge.net


text: Next Generation iPhone May Have FM Transmission CapabilitiesJesus Diaz4/06/09 5:15amFiled to: RumorApplenew iPhoneIphone 4giPhone 3GiPhone62EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Oh, what is this? In addition to the previously unearthed features, the next generation iPhone's guts will have full FM transmission and reception capabilities, according to its spec sheet: The BCM4329 includes both FM transmit and receive capabilities. FM transmit enables consumers to stream music directly from a personal media players (PMPs) or mobile phone to car stereos or home theater systems without having to purchase special adapters or use bulky cables. FM receive is already a popular feature that enables consumers to obtain real-time traffic information as well as listen to music, news and sports broadcasts on their mobile phones.I'm not interested in listening to radio or news—although many have been demanding this capability in iPods for ages—but I can't wait for the built-in transmission to the car stereo, as well as real-time traffic information data everywhere, independently of the 3G connectivity. [Broadcom via AppleInsider via 9to5] Advertisement Advertisement Update: Apple Insider say the previous chipsets had potential FM functionality as well, but Apple's declined to switch it on.Reply62 repliesLeave a reply


text:
Techart isn't one for subtlety, but its Geneva Motor Show offerings run the gamut from tasteful to deliciously vulgar. Oh, and they're both very, very fast.
7Techart Porsche 911 Targa 4S is a tuner's attempt at being tasteful
16Techart modified Porsche 911 Turbo S packs 620 hp, 0-62 in 2.8 seconds
- Steven J. Ewing
- Mar 5, 2014
- 16
Considering how many absolutely ridiculous tuner cars are featured in Geneva (stay tuned to see plenty, as our coverage continues), it's often refreshing to see some of the more modestly modified cars, like this new Porsche 911 Turbo S from the folks at Techart. Visually, there's a subtle body kit, new wheels, a new spoiler, and some lame decals on the front end, but it basically ends there. That's because Techart's mission is really about higher performance. Increased dynamism, as the Germans s
232012 TechArt Porsche 911 is visually dazzling, both inside and out
- Michael Harley
- Mar 7, 2012
- 23
One way to ensure that your brand-new Porsche 911 (a.k.a. 991) won't look like the one in your neighbor's driveway is to give TechArt a call. The famed German tuner has rolled out its version of the latest Carrera and Carrera S at the Geneva Motor Show and trust us, it won't be mistaken for anything from the factory in Stuttgart.
10TechArt previews new Porsche 911 upgrades ahead of Geneva
- Drew Phillips
- Feb 28, 2012
- 10
With the introduction of the new 991-series Porsche 911, a multitude of tuners have been hard at work over the last several months tweaking and customizing the latest iteration of Stuttgart's legendary rear-engined sports car. One of those tuners, TechArt, first previewed their take on the new Porsche 911 back in September, but they are now are ready to officially debut the car at the Geneva Motor Show next week.
15TechArt GTStreet RS [w/video]
- Matt Davis
- Nov 4, 2011
- 15
8Techart GTStreet RS is the ultimate Smurf-colored Porsche 911
- Drew Phillips
- Sep 15, 2011
- 8
The 2012 911 wasn't the only Porsche to debut at the Frankfurt Motor Show this week. German tuner Techart unveiled its new GTStreet RS based on the 911 GT2 RS. The car features a variety of upgrades, from carbon fiber aerodynamic enhancements to a power upgrade package that boosts the output of the twin-turbo flat-six to 710 horsepower and 664 lb-ft torque. Techart says that the GTSTreet RS can reach 100 km/h (about 62 mph) from a standing start in just 3.3 seconds and is capable of a top speed
2Techart previews new wares ahead of Frankfurt, Geneva
- Drew Phillips
- Sep 12, 2011
- 2
German Porsche tuning specialist Techart has released new renderings of some upcoming products including the GTStreet RS that will debut at this week's Frankfurt Motor Show, as well as their new individualization program for the 2012 Porsche 911 that will make its first appearance at the Geneva Motor Show in March.
29TechArt Porsche Cayenne Turbo rears its ugly head prior to Geneva debut
- Jeff Glucker
- Feb 25, 2011
- 29
19Techart powers 911 Turbo up to 620 hp
- Zach Bowman
- May 6, 2010
- 19
2010 Techart Porsche 911 Turbo – Click above for high-res image gallery
24Techart goes all matte with Panamera Black Edition
- Drew Phillips
- Apr 19, 2010
- 24
Techart Panamera Black Edition – Click above for high-res image gallery
15Geneva 2010: Techart debuts trifecta of tuned Porsches
- Drew Phillips
- Mar 4, 2010
- 15
Techart at the 2010 Geneva Motor Show - Click above for high-res image gallery
17Geneva Preview: Techart GTStreet R and Concept One joining the party
- Drew Phillips
- Feb 25, 2010
- 17
2010 Techart GTStreet R - Click above for high-res image gallery
5Geneva Preview: Techart to debut 911 Turbo, Turbo S
- Drew Phillips
- Feb 16, 2010
- 5
2010 Techart 911 Turbo - Click above for high-res image gallery
10TechArt's take on the Porsche Panamera is almost ready, but not quite
- Noah Joseph
- Feb 1, 2010
- 10
18TechArt squeezes more power out of Porsche 911 Carrera 4S
- Jonny Lieberman
- Nov 11, 2009
- 18
TechArt Porsche 911 Carrera 4S - Click above for high-res image gallery
11TechArt offers visual upgrades for Porsche Boxster and Cayman
- Noah Joseph
- Aug 24, 2009
- 11
TechArt Porsche Boxster and Cayman – Click above for high-res image gallery
12Twist and Shout: Techart among first to tweak Porsche Cayenne diesel
- Noah Joseph
- Jul 7, 2009
- 12
21Ass-engined slot-car of the Gods: Techart GTstreet R
- Damon Lavrinc
- Oct 29, 2008
- 21
Click above for a high-res gallery of the Techart GTstreet R
- Biggest automotive sales disappointments
- Fastest-depreciating cars in the United States
- Find and compare 2017 Models


text:
IGEM:University of East Anglia (UEA), Norwich, UK/2009/Notebook/NRP-UEA-Norwich iGEM/2013/08/21
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Floor Two
Minipreps of BL21 containing pETAntA and AntGp+RFP plasmids were prepared using 5ml from each overnight culture and incubated with PstI restriction enzyme for analysis by gel electrophoresis. We also prepared the biobrick BBa_K1041000 by cutting with restriction enzyme NdeI and analysing on an agarose gel. The large fragment was cut from the gel to be purified. This process should remove the extra NdeI sites that were introduced to the sequence.
We began designing the Outreach registry on our wiki pages.