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Now that the new graph server is going to (slowly) become the only graph server we need to make the following changes:
graphs-stage.mozilla.org -> graphs-stage-old.mozilla.org
graphs-stage2.mozilla.org -> graphs-stage.mozilla.org
graphs.mozilla.org -> graphs-old.mozilla.org
graphs-new.mozilla.org -> graphs.mozilla.org
This should _only_ be done during a scheduled downtime and in concert with landing changes to continue correctly sending data from both talos and build machines.
Alice, sounds like a Post Fx3.5 job - agreed?
There's been talk about having a downtime soon that would allow for burnage on the tree... if that's true than we should be able to get this done before 3.5. Otherwise we can sit on it.
If you want, I can add names for graphs-stage-old and graphs-old NOW and then you can change submission names on the ones you want to keep in place to the "-old" version at your leisure prior to the actual switch, then we can just change which one the non-"old" version points at on the switchover day and the ones that are allowed to follow the name can just follow it.
and then you could, at your leisure, switch the ones currently pointing at "-new" to point to the non-"new" version afterwards, since that name wouldn't immediately go away.
Once the switch happens would it be possible to have:
- all links to graphs-new go to graphs.m.o
- all links to graphs-stage2 go to graphs-stage.m.o
It would also be awesome if we could do some link hacking to save some other links:
- all links of the form graphs.m.o/#show go to graphs-old.m.o
- all links of the form graphs-stage.m.o/#show go to graphs-stage-old.m.o
Basically, the old link format contains the keyword 'show', and it would be nice if we could successfully redirect those links instead of breaking them.
How possible would this be?
Anything after a # doesn't get sent to the server, it's all processed client side. Only way to detect that would be with some javascript, which would make it an app-side thing to detect and refresh.
When can we do this? Thursday?
Just added code to handle redirects in comment #5 :
15:06:00 < alice> justdave: we're on for tomorrow evening
This is done now.


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U of T Medicine inks major agreement in China
The University of Toronto has signed an important agreement with China's Fudan University, which will see the two institutions develop joint activities to build education capacity in primary health care and public health.
Only three per cent of all physicians in China are family doctors — a situation that strains the Chinese health care system generally, and hospitals in particular. To help remedy this, the Chinese government plans to train 100,000 family physicians by 2020.
"This formalized partnership with Fudan University is an outcome of close collaboration benefitting both countries, as evidenced by the presence of health ministers from Canada and China," said Professor Cynthia Whitehead, the acting chair of U of T's Department of Family and Community Medicine (DFCM) who headed the delegation to China. "We are thrilled to expand our cooperation with Fudan University across several activities and continue finding collaborative ways to solve health care issues in both countries."
Under the agreement, DFCM — the largest family medicine training program in North America — will work with Fudan University's Department of General Practice to improve the quality of its general practice training. This work will include an exchange of faculty members between Toronto and Shanghai.
In addition, DFCM will develop a partnership with two community health services centres in Shanghai to assist with delivery and management of primary health care. Both parties agreed to strengthen ties and cooperate in the prevention and control of chronic diseases, with a focus on health management for high-risk populations.
The agreement — formally called a Memorandum of Understanding — adds to an already strong partnership between U of T and Fudan University. The Faculty of Medicine's Department of Molecular Genetics also has long history of cooperation with partners in Shanghai.
"This agreement is a critical step forward that signifies a deepening of the relationship between the Faculty of Medicine and Fudan University," said U of T Medicine's Dean Catharine Whiteside. "International collaborations like this one help build and improve learning networks, create unprecedented opportunities for collaborative research, and provide exciting cultural opportunities for our students and faculty — all aligned with the mutual commitment to improving health."
Posted Monday, April 21, 2014
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Queer Pacific Indigeneity: Constructing Our ArchivesSeptember 26, 12:00pm - 1:15pm
Mānoa Campus, Henke Hall 325
In this talanoa/talk story panel, David Kealiʻi MacKenzie and Tagi Qolouvaki, both queer-identifying, Pacific Islanders (Native Hawaiian and Fijian-Tongan), discuss how their respective genealogies, including as activists, scholars, and writers, have informed their journeys to find and construct archives of queer pacific indigeneity. Along the way we hope to share a few poems, photographs, memories of community, and some of the many questions that guide and accompany us.
D. Kealiʻi MacKenzie is Kanaka Maoli poet, librarian, and scholar who was originally born and raised in Western Massachusetts. He received his Master of Library and Information Science in 2012 from UH Manoa is currently a graduate student with the Center for Pacific Islands Studies. His poems have appeared in Flicker and Spark: A Contemporary Queer Anthology of Spoken Word and Poetry, Assaracus: A Journal of Gay Poetry, Mauri Ola: Contemporary Polynesian Poems in English, and The Yellow Medicine Review.
Tagi Qolouvaki is Fijian-Tongan on her mother's side and German-English on her dad's side—altogether a very mixed, queer and feminist P.I. Born and raised in Fiji by a few beautiful men and many powerful women, she is currently a student of Pacific literature at UH Mānoa, and has had poetry published in Diasporadic 2, Mauri Ola: Contemporary Polynesian Poems in English, and The Yellow Medicine Review.
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The operations, which employ about 1,100 people, are not sufficiently profitable, "despite restructuring and improvement efforts."
Hate crimes are on the rise in Canada, which has an estimated more than 100 right-wing extremist groups, including 20 to 25 in Quebec
Quebec's political leaders might not be so quick to dismiss Marine Le Pen if she showed up at the doorstep today.
Launched in 1995, Cinemania owes its success – and future – to her vision and chutzpah
Marilou, a former pop/rock singer and anorexic, and her husband, Alexandre Champagne, have a book, based on their food blog, Trois fois par jour. They aim to transform the relationship people have with food
Canadian Adam Scott surprised the aviation world in June 2013 with his plan to launch Odyssey Airlines, an upscale carrier flying between London City Airport and the eastern U.S. and Canada.
Three picks by wine critic Bill Zacharkiw.
Yes, you read those hours correctly. Ma'tine is strictly a daytime operation, limiting itself to light breakfasts, lunches and Saturday-only brunches.
From museums to nightclubs and burial grounds to hotels, stories of hauntings in our city abound. Read on and judge for yourself ...
Carole Laure's take on twentysomethings: They're different from my generation. They want everything
Gender-bending police thriller mixes horror and fable at Festival du nouveau cinéma.
When Montrealer Madeleine Tremblay returned from France in 1978 to found Servier Canada Inc. with three associates in Pointe Claire, she had one burning ambition. "I wanted to build the embryo Canadian unit into one of the top players in the parent Groupe Servier's fast-developing global pharmaceutical research and production network," she said Friday. "We've […]
Nelly Trocmé Hewett, the daughter of two quiet heroes of the Second World War, will be in Montreal later this month to talk about her parents: Magda and André Trocmé, who inspired a network of resistance to the Vichy government's deportation of thousands to concentration camps. A book of selected writings by the Trocmés, translated […]
Lead actors Anne Dorval and Antoine-Olivier Pilon and cinematographer André Turpin each won a Bayard d'Or at the Festival International du Film Francophone de Namur Friday in Belgium.
Eighteen years ago, 17-year-old Patrice Bernier had a crucial decision to make regarding his future.
Three picks by Bill Zacharkiw.
Shortly after killing and dismembering Lin Jun, Luka Magnotta went on the travel site Expedia in the early hours of May 25, 2012, and bought a plane ticket to Paris for the following evening.
No matter how reluctant this war-weary nation may be after a long, costly engagement in Afghanistan, nor how proud we are of our decision to say no to George W. Bush's 2003 invasion of Iraq, Canada cannot – and should not – avoid assuming its international responsibilities in the battle against the Islamic State.
Regulations often ban this zero-emmission mode of transportation
Montreal-based BioAmber Inc. has signed a five-year contract to supply a leading Chinese industrial group with bio-based chemicals from its new US$135 million Sarnia plant due on stream early next year. Xuchuan Chemical (Suzhou) Co. Ltd. will initially buy between 300 and 500 tonnes a year of the Sarnia plant's production, BioAmber said Thursday. Financial details were not disclosed.


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Bloomfield Design Studios has been privileged to capture Central Oklahoma special events since moving their location from Hollywood, Florida in 2009. Photography Specialists with over ten years of experience, we have photographed a broad range of events spanning from simple elegance to modern artistry. Coupled with creative vision, style, and bold imagery, Bloomfield Design Studios is your one stop shop for all of your photographic needs.
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This is a perfect capitol square. In the summer it is surrounded by the farmers market. In July by Art in the Park. A lovely location!
One of my favorite things about capitol square is the outdoor farmer's market!! So many vendors. It's great to stroll the square and purchase breakfast from a vendor.
The capital building is a lovely building! On a nice spring day, one shouldn't miss going to the top of the building to look at the lakes and the city from above. Afterwards a stroll around the square is a great place to get coffee or a meal. There are concerts and farmers markets around the square various times of...
When in Madison you really need to stroll around the Capitol Square. Certainly spring, summer or fall are the optimal weather times, along with the grounds blooming. Surrounded by great restaurants and museums for both young and adult. Don't forget to tour the Capitol itself! This is the 100th anniversary year, 2017. During the summer you can also catch concerts...
We went to the farmers market around the square on Saturday morning and it was great to see all of the local farmers and stalls as we walked around the Capitol. It is a beautiful building and worth a walk around.
Almost as iconic as the US Capitol, this is the kind of architecture that endures, but will likely not ever be duplicated. The "Square" is the governmental/cultural/business hub of a great city. Situated on a high point between Lakes Mendota and Monona, you do not want to miss it.
This is such an exemplary example of a State Capitol. It is located at one end of a straight street, State Street, that connects directly down to the University of Wisconsin Campus, located on the other end. We spent time walking the four corners of the square one sunny morning. It was near the lunch hour. People were having lunch...
We love coming to Madison to visit our son. It's a great city. Since he lives near State Street, we spend a lot of time walking around. We always go up to the Capitol. Today we enjoyed walking around the inside and outside. It's such a beautiful building. So many interesting entries. We caught a lot of Pokémon around the...
Capitol Square is a must-see/visit place in Madison, particularly on Saturdays during Farmer's Market season. The impressive Capitol is surrounded by beautiful lawns and a number of shops, restaurants and cafes. Nice place.
I walked around the Capitol building to take in the Square. It was winter, but they had all of the sidewalks and stairs cleared.
Mostly everything was put away for the winter but it was still well maintained.
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are there any tour rides (handicapped accessible) available to site-see around the state capitol, state street or surrounding areas?
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Zendaya Coleman net worth: Zendaya Coleman is an American actress, singer, and dancer who has a net worth of $5 million. Born in Oakland, California, Zendaya Coleman began training and performing with the California Shakespeare Festival as a child. She went on to attend the Oakland School for the Arts and the American Conservatory Theater. She began her professional career as a model, appearing in ads for Macy's, Old Navy, and "iCarly"-related merchandise. She also appeared as a dancer in both commercials and music videos. In 2010, she was cast on the show that would make her a household name, as Rocky Blue on the popular Disney Channel series, "Shake It Up". Since then, she has also done voice over work for the animated film, "Pixie Hollow Games", and co-starred in the Disney Channel movie, "Frenemies." She has also begun a music career, and launched her first tour in August of 2012. She is a contestant on the 16th Season of "Dancing with the Stars".
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The Big Island of Hawaii 2) Hilo & Hamakua Coast
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Hilo is the largest town on the Big Island although its population is less than 50,000 -- "small town" by most standards. Its history dates back to the sugar plantation days when it was a thriving center of commerce, and it has a charming historic Bayfront district that's seen renovation and the opening of restaurants and small shops (to service cruise ship and other tourists). The city has know its share of misfortunes during the past century including tsunamis, lava flows that just missed it and a financial collapse when the sugar cane industry crashed, but it's hung in there and is slowly coming back
My favorite place in the city is along the southern side of Hilo Bay. Here you will find a string of older hotels along Banyan Drive and the very pretty Lili'uokalani Park, named in honor of one of Hawaii's last queens who gave this land to her people, featuring Japanese-style ponds and garden. I enjoy walking through and relaxing in this park and taking in the nice views of Hilo Bay, the city nestled on the lower slopes of Mauna Loa and, on a clear day, the towering summits of Mauna Kea and Mauna Loa. The park is also a great place from which to enjoy a picnic or the sunset.
There are an assortment of small museums in Hilo that might capture your interesting including the Pacific Tsunami Museum and Lyman Museum (featuring nice exhibits on Hawaii's natural history). The 'Imiloa Astronomy center is a planetarium located on a 9 acre campus above the University of Hawaii -- Hilo, and would be a great place to visit with kids. A popular event is the Hilo Farmer's market where you have the opportunity to buy great fruits and vegetables and some unusual foods and crafts. The market is held every Wednesday and Saturday.
On the north edge of town lies one of the prettiest waterfalls anywhere, Rainbow Falls, which is well worth a stopPe'epe'e Falls, or explore the nearby Kaumana Cave, a lava tube without any artificial lights (it gets dark very very quickly so make sure you are prepared with a good flashlight and backup if you go).
South of Hilo (Puna)
The famous Mauna Loa Macadamia Nut corporation has its plantation and processing plant just outside Hilo on the road to Volcanoes National Park, offering simple tours and, of course, macadamia nuts for sale. Macadamia nuts have the hardest shell of any tree nut and are terrific roasted with sea salt or dipped in chocolate. Further south is Lava Tree State Park, a lush park with large dark columns of lava showing where molten lava cooled and hardened around tree trunks, while liquid lava flowed away leaving behind these now hollow vertical sentinels. Heading further south and west you might run into the eastern most lava flows of Kilauea and there may actually be flowing molten lava here (check with the Rangers at Volcanoes National Park or on the park website). There are number of black sand beaches and tide pools in this region which are fun to explore.
North of Hilo (Hamakua Coast)
I think the drive between Hilo and Waimea is the prettiest on the Big Island -- a daunting claim for an island filled with great vistas
Akaka Falls State Park is a little off the main road but very worthy of visiting. You'll be treated to a great hike through the jungle the highlight of which is Akaka Falls which drops more than 400 feet over a cliff. There is a paved fairly easy hiking trail around the park offering a good way to see some of the many plants that comprise this rain-forest. On your way back to the highway be sure to stop at Mr. Ed's Bakery in Honomu for a cool drink, great pastry and a chance to buy some of Mrs. Ed's wonderful homemade jams to take with you as a tasty souvenir of the island (including such exotic flavors as papaya, mango, passion fruit and coconut).
Another must stop is the Waipi'o Valley outlook. Waipi'o is the Valley of the Kings and is sacred to Hawaiians. King Kamehameha was hidden in this valley to protect his life as a child. It's a beautiful stereotypical Hawaiian Valley which is breathtaking to see from the overlook but difficult to get into
Hilo is a great base from which to explore Volcanoes National Park. The best restaurants in the region are in Hilo. A classic favorite is Ken's House of Pancakes, a 24 hour diner that specializes in filling hearty breakfasts. A great restaurant is the Hilo Bay Cafe, tucked into a strip mall near Walmart but with wonderful atmosphere and superb food. A trendy spot which has great pizzas and atmosphere (food is otherwise fine -- nothing earthshaking) is Cafe Pesto in the Bayfront area.
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Econo Lodge Inn & Suites
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Day 7 & 8 - I think
... a brief detour through Hope, where President Clinton once lived, and boy was that a depressed, dying town of boarded up businesses and very old houses. I arrived in Hot Springs around 3, took in the sites and settled down at the only NP campground in the park. This place has a lot of history, All centered around the hot water coming out of the ground and the old bath houses in the mid 1850s that sprouted up ...
Sittin' on Top of the World
... explains why biker noise I broke the peace last night until the wee hours of the morning. I was just happy not to fight the traffic again.
My day was given to hiking the perimeter of Hot Springs National Park, a loop I thought was a little more than 10 miles but turned out to be more like 14. Perhaps the best part was listening to the ...
Whole Lotta Shakin' Goin' On
... walk). For dinner: ribs, chopped pork, beans and slaw at McClard's Bar-B-Q, established in 1928 under the watchful eye of President Clinton and Keith Ric***********g others). The ribs were really, really good; the chopped pork just ok. Now we hope for a decent night's rest with the rumble of unmuffled engines cruising the highway beyond our motel. Tomorrow brings a short pause in our travels and a second day in Hot ...
Dallas to Hot Springs
Said a reluctant good bye to Kelly, Mike and the kids. We had such a good time with you! Mike thanks for helping with the motor home leak. We now have a Tupperware bowl glued to the roof of the motor home to help cover the satellite wires that were allowing water to flow freely into the motor home. Left Dallas at 11:00. Caught up with hurricane Bill's rain and ...
Day 4 - Took a Bath, Climbed a Mountain
... very sharp hairpin turns. We're never one to miss out on an exhilarating ride.
At the top of the east mountain, there is a 216 foot tall observation tower. Luckily there is an enclosed elevator to the top with 2 observation floors. The lower floor is fully enclosed in glass, and gives great views of the surrounding mountains. Very safe, and not at all scary. The upper observation floor ...


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Warriors bury Clippers rivalry with 50-point barrage in third quarter
Warriors bury Clippers rivalry with 50-point barrage in third quarter
OAKLAND -- The Warriors-Clippers rivalry, dead for a couple years, was buried 50 points deep Thursday night.
There were, and may always be, occasional fits of temper in which both players and officials will be tested. That surely was the case during the Warriors' 123-113 victory over LA at Oracle Arena.
But scoring 50 points in 12 minutes, as the Warriors did in the third quarter, is a rather emphatic statement that serves as its own embellishment. It sent the Clippers back home, unable to muster even a half-hearted comeback.
"That was incredible," Kevin Durant said of third-quarter scoring frenzy.
"That's a lot of points," Klay Thompson said. "It's that the most we've had all season?"
Well, yes, it is. The Warriors' previous high for points in a quarter was 45, also against the Clippers, on Jan. 28.
So this was astonishing even to the Warriors, the highest-scoring team in the NBA for three seasons running. This is the Warriors' fourth 50-point quarter in franchise history and their first since March 1989. They made nine 3-pointers, tying a franchise record for triples in a quarter.
Fifties are rare, period; the last one by any team in the NBA was on March 25, 2014, when the Lakers dropped 51 in a quarter against the Knicks.
"I had no idea we scored that much," said Stephen Curry, who scored 20 in the quarter -- 17 in the final 3:37 before halftime. "Obviously, coming back from 12 down to having a double-digit lead, it all started with the defensive end and finding transition."
The scoring breakdown: Curry scored 20, Durant 15, Thompson 5, Andre Iguodala and Zaza Pachulia 4 each and JaVale McGee 2. The Warriors shot 73.9 percent (17-of-23) in the quarter.
"It all started from our defense, getting rebounds and getting out in transition," Durant said.
The Warriors forced five LA turnovers in the quarter, off which they scored 11 points. Trailing by 12 at the half, they led by 12 entering the fourth quarter.
The Warriors have defeated the Clippers 10 consecutive times overall. They've beaten them 11 straight times at Oracle Arena. The average margin of victory in four games this season is 21.5 points.
This was a matter of how the Warriors responded to the threat posed by LA in the first half.
"I'm not sure what needed to happen," Draymond Green said. "But I know we took that quarter over. And it was pretty spectacular."
With Clippers rivalry over, Warriors feed off feud with Foster
With Clippers rivalry over, Warriors feed off feud with Foster
This will come as a sharp blow to Warrior fans who like things the way they are, but they probably can no longer use Scott Foster as an alibi for failure, or a stalking horse for rage.
Well, I mean they can, but let's be honest here – the evidence just doesn't support it any more.
Foster, who no matter what you say is one of the elite officials in the league, has also been cast as a bête noire by all things Golden State. Either he's imperious, or he's standoffish, or he makes himself too conspicuous – they're all standard complaints made of all officials who aren't otherwise branded as just plain terrible.
Only Foster isn't terrible, given the fact that he has worked a series of NBA Finals, and that remains the gold standard for officiating.
But the Warriors bang their heads against the backboard when he works their games, and were on the verge of doing that again Thursday night against the Los Angeles Clippers. Foster called third quarter technicals on Andre Iguodala and the Warrior bench, and J.T. Orr called one on Draymond Green, all in the space of 6:34. The Warriors were unhinged, the fans were unhinged, innocent bystanders were being hit with flying hinges throughout the arena.
And in that stretch, the Warriors outscored the Clippers, 26-15, en route to a 50-point quarter (the first in two seasons and the third since the turn of the millennium) and another harsh slapdown of what used to be known as the Warriors-Clippers Cavalcade Of Hate, this time 123-113.
It isn't that any more, not close. Truth is, the Warriors have won 10 consecutive games against the Clips, but probably never quite at decisively as this. At the game's most lopsided stretch, Golden State outscored Los Angeles, 72-33, in a shade over 17 minutes.
Because that's what they do.
Only this time, the comeback was not fueled by the existence of the Clippers, who had outplayed them pretty convincingly for the first 22 minutes and change, but with the officials, who as we have said before irk the hell out of them when their number includes Foster.
Who, again, is one of the game's best officials. I think it's a personality clash, to be frank, in which both sides can take some blame.
Truth is, though, when a team can go for 50 in a quarter and still have time to engage in a feud with the officials, it is making a kinky little statement about what they can do when enraged, and how difficult it is to stop them when they have a serious mad-on.
Yes, it is probably stretching a point to make this case, especially when the Warriors make 17 of 23 shots (9 of 15 from three) and assist on 13 of the 17 field goals. It is probably minimizing Stephen Curry's 20-point quarter and his four assists, or Kevin Durant's 15 and five rebounds, or David West imposing his body between Green and the officials to keep him from getting T'd up again for the second successive game.
But we have already established that rivalries are dying at their feet left and right. In the last three years the Clippers have gone from the Warriors' arch-enemies to a team that has finished an aggregate 44 games behind the Dubs in the standings, making whatever animosity they can still stir
Against the Clips a curio of a much earlier time. The Oklahoma City Thunder have come and gone, and even the Durant-Russell Westbrook has lost its last bit of elasticity.
Oh, there is still Cleveland, but that cannot be resumed for another 14 weeks at the earliest.
The Warriors, in short, have run out of opponents, and given that they will manufacture a foe when one does not otherwise exist, Scott Foster may have to serve for the time being, even if he is nothing but an intermittent prop to amuse the customers when the game cannot provide.
Though you'd have to think the third quarter Thursday makes that pretty thin oatmeal. The Warriors ate an entire game in 12 minutes, including the officials. They seemed like they got their fill.


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HOUSTON -- The Houston Astros aren't going to make too much out of winning two straight games for the first time in more than a month.
But for this last place team, it sure feels good to end a series on a high note.
Pinch hitter Jason Michaels hit an RBI single in the 11th inning to lift the Astros to a 3-2 win over the Washington Nationals on Wednesday and give Houston consecutive victories and a series win for the first time since taking two of three from the Dodgers in June.
"It's good to see these guys rewarded for some good play," Houston manager Brad Mills said. "To have these back-to-back wins and win a series is big."
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Humberto Quintero singled to right field before advancing to second on a sacrifice bunt. He took third on a single by Michael Bourn to set up Michaels' game-winner to center off Todd Coffey (3-1).
Neither team got a hit in a scoreless 10th inning before Jayson Werth doubled with one out in the 11th. Wilton Lopez (2-4) retired the next two Nationals to end the scoring threat.
Houston starter Brett Myers is hopeful that the series will help the Astros get something positive going in the second half of the season.
"We need some momentum going right now," he said. "Obviously we're not playing our best baseball, but that series right there we played pretty well. It was close games. We slugged with them yesterday and we pitched with them today and ultimately we were able to come out winning."
It was the 15th extra-inning game for the Nationals this season and dropped their record in those games to 9-6.
Houston rookie Jose Altuve picked up his first major league hit with a single to right field off Tyler Clippard with two outs in the ninth. Clippard walked Hunter Pence before retiring Carlos Lee to send it to the 10th.
"Tyler was Houdini," Nationals manager Davey Johnson said. "He came in with two men on and nobody out and got out of it. He got into trouble the next inning and got out of it."
Werth had three hits and drove in Washington's only runs with a two-run homer that tied it 2-all in the sixth inning. It was his first homer since June 16.
"It's kind of like all year -- we aren't matching up," he said. "If we pitch, we don't hit. You hope that we will match up. That's how you win games ... the pitching has been good all year, and we've been picking up the hitting. We are going to have to pitch, and we are going to have to hit if we are going to play in the postseason."
Henry Rodriguez walked Pence and Lee with no outs in the eighth inning and was replaced by Clippard. Brett Wallace put down a sacrifice bunt and Clippard intentionally walked Chris Johnson to load the bases. Clippard got out of the jam when Clint Barmes popped out and Quintero struck out.
Myers yielded eight hits and two runs in seven innings but did not factor into the decision, remaining winless since June 17.
"I didn't feel like I had my best stuff, but I was able to make pitches when I needed to," he said.
Livan Hernandez, who started for the Nationals, allowed seven hits and two runs with three strikeouts in six innings. He has allowed seven or more hits in five of his last six starts.
"He made quality pitches. He kept us in the ball game," Johnson said. "I hate that we couldn't win it for him, but unfortunately, we couldn't punch one across."
Hernandez retired six of the last seven he faced and was replaced by Rodriguez, who threw a 1-2-3 seventh.
Michael Morse singled in the sixth inning and Werth followed with his tying homer. The home run to the Crawford Boxes in left field was the 24th Myers has allowed this season -- second-most in the majors. Rick Ankiel singled after the homer, but Myers retired the next two Nationals to end the inning.
Quintero pushed Houston's lead to 2-0 on an RBI double in the second inning.
Pence tripled in the first inning on a ball that bounced off the wall in left field and scored on a single by Lee to give Houston a 1-0 lead.
Altuve started at second base on Wednesday in his major league debut. He was called up from Double-A Corpus Christi on Tuesday after the team traded second baseman Jeff Keppinger to the San Francisco Giants.
"I was a little nervous in the beginning of the game," Altuve said. "And then just went out to play and it was pretty good."
- The Astros optioned LHP Wesley Wright to Triple-A Oklahoma City to make room for INF Matt Downs, who was moved from the paternity leave list to the active roster after the game.
- Nationals LHP Tom Gorzelanny threw on Wednesday for the first time since twisting his right ankle Sunday in a home-plate collision. Johnson said he still isn't sure if he'll make his scheduled start on Saturday. The Nationals could skip him without adding a pitcher to the rotation because of Thursday's scheduled off day.
- Houston OF Jason Bourgeois [right quadriceps strain] went 2 for 5 with an RBI in a rehabilitation assignment for Oklahoma City on Tuesday and is scheduled to play again Wednesday.
- Johnson doesn't expect C Ivan Rodriguez [strained right oblique] to come off the disabled list when he is eligible on Friday, but he will likely come off soon after that.


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> Dennis, I found this photo of TUL KEREM as I was putting together
>this years photos. TUL is Henry Danielson 1974. This looks like your
>misnamed of last week. This is also a test of the new eGroups address.
> Harold Peters
>Beautiful View Iris Garden
Hey! You are absolutely right, that looks just like TUL KEREM. Thanks.
Accurate impartial advice on everything from laptops to table saws.


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Renal cortical necrosis (RCN) is a rare cause of acute kidney injury secondary to ischemic necrosis of the renal cortex. Acute tubular necrosis after binge drinking is usually attributed to volume depletion, idiosyncratic reaction to alcohol, rhabdomyolysis or a combination with non-steroidal anti-inflammatory drugs. Binge drinking itself as a cause of RCN has not yet been reported. We report a case of a 25-year-old Asian male who developed bilateral RCN following binge drinking.
Renal cortical necrosis (RCN) is a rare cause of acute kidney injury (AKI) secondary to ischemic necrosis of the renal cortex (Kim, 1995). Acute tubular necrosis (ATN) after binge drinking is usually attributed to volume depletion, idiosyncratic reaction to alcohol, rhabdomyolysis or a combination with non-steroidal anti-inflammatory drugs (NSAIDs) (Prakash et al., 2007). Binge drinking itself as a cause of RCN has not yet been reported. We report a case of a 25-year-old Asian male who developed bilateral RCN following binge drinking.
A 25-year-old Asian male presented with a 5-day history of nausea and vomiting and a 4-day history of back pain and anuria. He had been drinking alcohol heavily every day for 2 months, with particularly heavy alcohol intake without meals over the 3 days prior to the onset of symptoms. He had consumed a total of ∼30 l of soju for 2 months. Soju is a distilled liquor made from fermented potatoes and its alcohol content is 20%. He also had consumed a total of ∼13 l of beer, 3 l of soju and 0.75 l of hard liquor for last 3 days. He had also not eaten proper meals for 2 months. He had no significant medical or family history and was on no medication.
He was evaluated at a local hospital before admission and underwent a non-enhanced abdominal computed tomography (CT) due to anuric renal impairment. There was no increase in urine output after administration of 3 l of normal saline, so he was transferred to our hospital. On admission, the patient was acutely ill, complaining of discomfort over the entire abdomen and back pain. The blood pressure was 130/90 mmHg, the pulse 73 beats per minute and the body temperature 36.7°C. There was bilateral tenderness of the costovertebral angle, and he had severe anuric renal impairment (urea 75 mg/dl, creatinine 12.1 mg/dl). A urinalysis showed hematuria and proteinuria. Blood count hemoglobin level was 13.6 g/dl and white blood count was 25 200/μl. High-sensitivity C-reactive protein concentration was 29.07 mg/l, lactate dehydrogenase (LDH) was over 3000 IU/l (normal 285–540) and a clotting screen showed slightly increased values (prothrombin time international normalized ratio 1.42 and partial thromboplastin time 49.4, control 39.8). Other laboratory data included creatinine phosphokinase 21 IU/l, aspartate aminotransferase 74 IU/l, amylase 56 U/l, lipase 31 U/l and total CO2 19 mEq/l. Fluorescent anti-nuclear antibody, anti-neutrophil cytoplasmic antibody and cryoglobulin were all negative, as were serologic markers for viral infection and a bacterial infection culture.
An ultrasonographic study showed normal sized, unobstructed kidneys with prominent pyramids and a hypoechoic renal cortex (Fig. 1). Abdominal contrast-enhanced computed tomography (CECT) showed diffuse and bilateral cortical hypodense areas surrounded by capsular enhancement in both kidneys (Fig. 2). Hemodialysis was initiated on the day of admission. His daily urine output increased to 1500–2000 ml on the 8th day of dialysis, but his serum creatinine level did not decrease. Renal biopsy was performed on the 28th day of admission. Percutaneous kidney biopsy showed extensive coagulation necrosis in subcapsular cortex and hemorrhage with ghosty renal architecture (Fig. 3A). The central necrotic area showed a loss of normal cytologic features of necrotic tubular epithelial cells, markedly congested glomeruli (Fig. 3B), focal interstitial hemorrhage and fibrin thrombi in an interlobular artery. The histological findings of coagulation necrosis and hemorrhage are consistent with diffuse cortical necrosis. On immunofluorescence study, focal trace immunoglobulin M staining was noted in the glomeruli which tended to exclude an immune-mediated glomerulopathy. He underwent allogeneic kidney transplantation 6 months later.
RCN accounts for 2% of all cases of AKI (Kim, 1995; Prakash et al., 2007). The lesions are caused by significantly diminished renal arterial perfusion secondary to vascular spasms, microvascular injury or intravascular coagulation. The accurate pathogenesis of RCN is not known, but reported main causes include sepsis, prothrombic states, acute pancreatitis, drugs and trauma (Kim, 1995; Prakash et al., 2007). Binge drinking of alcohol has not yet been reported as a direct cause of RCN.
AKI after binge drinking is usually attributed to volume depletion, a condition produced by vomiting and urinary loss. This in turn may be caused by the suppression of antidiuretic hormone (ADH) by alcohol, an idiosyncratic reaction to alcohol or alcohol-induced rhabdomyolysis (Hirsch et al., 1994). Binge drinking associated with the use of NSAIDs that interfere with renal autoregulation is a risk factor for the development of AKI (Johnson and Wen, 1995). AKI is reversible and has led to ATN in previously reported cases in which a biopsy was performed. We were able to rule out AKI due to binge drinking associated with NSAIDs because our patient had not taken any NSAIDs. We also ruled out AKI due to other causes because there was no evidence of alcohol-associated pancreatitis or rhabdomyolysis and the renal biopsy revealed RCN rather than simple ATN.
On admission to our hospital, we began dialysis because of continuing anuria after a sufficient intravascular volume load. Before dialysis, we performed an abdominal CECT to rule out RCN due to elevated LDH levels and sudden back pain. An elevated LDH level is highly sensitive for acute renal infarction and is usually not observed in patients with other types of AKI. Our patient had no risk factors for renal infarction (such as atrial fibrillation). If renal infarctions including RCN are suspected, CECT may be an appropriate diagnostic tool because RCN can be missed on non-CECT and contrast-induced kidney injury can be prevented by dialysis.
Lipotropic factors such as choline, methionine, B12 and folic acid play important roles in diverse biological species. In rats, diets deficient in these factors can cause renal disorders such as ATN and RCN (Klatskin and Krehl, 1954; Montes et al., 1980). In the kidney, choline is involved in the syntheses of phospholipids and the neurotransmitter acetylcholine and is oxidized to produce the methyl donor betaine (Parks and Smith, 1969; Acara and Rennick, 1972). Choline deficiency produces acute renal lesions in young rats, which are often associated with fatal hemorrhagic necrosis approximately 6–10 days after the implementation of a choline-deficient diet (Griffith, 1958). Alcohol increases choline requirements and may induce a state of relative deficiency when the diet is marginal in lipotropic activity (Parks and Smith, 1969). Therefore, alcohol can aggravate choline deficiency, and severe choline deficiency can cause RCN in rats. Archer et al. (2010) reported RCN in a fussy eater and suggested that severe hyperhomocysteinemia as a result of vitamin deficiency is associated with increased risk of endothelial activation and arterial thrombosis (Remacha et al., 2002). Unfortunately, we did not check the status of lipotropic factors in our patient. However, daily alcohol consumption and binge drinking without meals can lead to vitamin deficiency, including that of choline. We suggest vitamin deficiency aggravated by binge drinking as the possible cause of RCN in our patient.
Binge drinking is not rare in the general population. Its potential nephrotoxicity (including ATN and RCN) should be brought to the attention of medical professionals as well as the general public. Vitamin deficiency is a possible cause of RCN in binge drinkers.


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Wendell Scott: A Race Story
NASCAR Media Group's docudrama about the first African American to win in NASCAR. The Carolina Vintage Stock Car Racing Association appeared in the film. All rights reserved to NASCAR Media Group and ESPN. I do not own this video, I just want to share it. Visit carolinavintagestockcars.org to learn more about the filming and the cars and drivers that appeared in it.
Street Legal 1936 Dirt Track Race Car listen and watch
This is one cool hot rod. It is a real 1936 (body) modified dirt track race car that has been converted to drive on the street. See more about this car at http://www.LegendaryCollectorCars.com under the Featured Car page.
11 year old Macy Causey first ever Late Model Sportsman Practice
11 year old Macy Causey practicing her Dirt Late model Sportsman car at Langley Speedway!! She didn't even stall the car outtaking off!! We had to practice on the asphalt track because the dirt track had not opened yet.
Legends Cars SOUND In Action On The Track
You can also find and follow me on: - Flickr: http://www.flickr.com/photos/19bozzy92/ - Facebook: https://www.facebook.com/19Bozzy92YT - Google+: https://plus.google.com/100567781241722617164/posts - Instagram: https://www.instagram.com/ste19bozzy92/ This video is about two Legends Cars I saw at the racetrack of Castelletto di Branduzzo. The Legends are very little car (as you can see they are smaller than the various Mini on the track) but they must be really funny to drive: the cars have a motorbike engine which can produce a power of 140 bhp. The car, thanks to its very light weight, is able to accelerate from 0 to 100 km/h (0-60 mph) in just 3,7 seconds. What do you think about this cars?? Camcorder: Canon Legria HF M46 + Canon DM-100 Microphone Where: Castelletto di Branduzzo, Italy Link To My Channel: http://www.youtube.com/user/19Bozzy92?feature=mhee THANKS FOR WATCHING AND SUBSCRIBE!!!


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Superfund Site: LINDANE DUMP, HARRISON TOWNSHIP, PA
Superfund Site Profile
The Lindane Dump site is located in Harrison Township in Allegheny County, Pennsylvania. The area consists of a 14-acre park and a 47.5-acre lower project zone that includes a closed landfill area. The site received about 400 tons of dumped powdered lindane pesticide waste and other industrial waste from 1900 to 1950. Industrial waste dumping continued after the sale of the property in 1965. Waste disposal practices contaminated soil and groundwater with pesticides and other chemicals. In 1976, the property owner donated part of the site to Harrison Township for use as a park. Following cleanup, operation and maintenance activities are ongoing.


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Songkran is the traditional New Year celebrations, which is observed from April 13 to April 15, 2017in Thailand. It is similar to the Chinese Ching Ming or the Christian Easter celebration. It is also a celebration of love, which is used to show respect especially to elderly family members. Similar celebrations are also held in Laos, Cambodia and Myanmar. Most official institutions and businesses, besides large shopping malls, are closed on Songkran.
Songkran is celebrated during the hottest month of the year with much joy and water. So it is common that people get doused with water in the streets, which is very welcome due to the heat. To older persons respect is shown by sprinkling them with water. Furthermore, part of the tradition is to honor Buddha by dousing Buddha figurines with water. Water is an important element at Songkran, as it represents the cleaning for the New Year.
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www.cute-calendar.com • Songkran festival 2017 - Thailand - 13.-15.04.2017 Copyright © 2017


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Results 26 to 31 of 31
Thread: Article: Evolution Raceworks and BMS (Burger Motorsports) hit 270 wheel horsepower with tune and downpipe for the F30 328i N20 turbo 4-cylinder
07-31-2012, 06:18 PM #27Supporting Vendor
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We have the N20 downpipes, Stage1 tuning, and CAN Tool (to suppress the codes) all in stock and ready to ship.Burger Motorsports
Home of the Worlds fastest N20s, N54s, N55s, N63s, S55s, and S63s!
It is the sole responsibility of the purchaser and installer of any BMS part to employ the correct installation techniques required to ensure the proper operation of BMS parts, and BMS disclaims any and all liability for any part failure due to improper installation or use. It is the sole responsibility of the customer to verify that the use of their vehicle and items purchased comply with federal, state and local regulations. BMS claims no legal federal, state or local certification concerning pollution controlled motor vehicles or mandated emissions requirements. BMS products labeled for use only in competition racing vehicles may only be used on competition racing vehicles operated exclusively on a closed course in conjunction with a sanctioned racing event, in accordance with all federal and state laws, and may never be operated on public roads/highways. Please see http://www.burgertuning.com/emissions_info.html for more information on legal requirements related to use of BMS parts.
Terry@BMSChrome Space Bar Issue: http://www.boostaddict.com/showthrea...338#post738338
Stage 2 or 2.5 E9X M3 S65 V8 supercharger kit for sale: http://www.boostaddict.com/showthrea...r-kit-for-sale
I'm looking into this as an option, my brother is about to order his 328i m-sport soon...
09-02-2012, 12:34 PM #30Member
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Do you think I can get away with running a catless downpipe with an external wideband o2 that fakes the value back to the ecu anyway? (from plx if you know them)
379+495+140 is a pretty decent deal for this type of power really and maybe we could even get a package. I have never tuned another car that is this inexpensive within months of being released.
One of the graphs I saw seemed to indicate that the boost runs in the 20psi area or 3psi over stock because the stock map seems to vary a bit.
Terry@BMSChrome Space Bar Issue: http://www.boostaddict.com/showthrea...338#post738338
Stage 2 or 2.5 E9X M3 S65 V8 supercharger kit for sale: http://www.boostaddict.com/showthrea...r-kit-for-sale


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My anguish at being childless at Christmas: Samantha Brick fled a nativity play in tears... the only present she's bought this month is for the child she yearns to have after years of trying
After an unsuccessful IVF attempt, the writer tells how her longing for a child is all the more agonising at Christmas time
- Samantha and her husband are preparing to embark on another round of fertility treatment
Anguish: At 41, Samantha Brick is longing to be a mother
My husband and I are squeezed into tiny plastic seats, our knees touching, and I'm clutching his hand tightly.
My beaming mum, stepfather and sister are on the other side, their faces softly lit by the glow of candles and twinkling Christmas lights.
Behind us, we can hear the soft shuffle of feet as hundreds of parents pack the pews of the small village church hall. They're digging into handbags for glasses, cameras and, of course, tissues.
They'll be needing plenty of tissues.
For in a short few moments will come the highlight of every parent's and grandparent's calendar: the Christmas play.
can see them and feel them now — craning forward, pushing cameras
between shoulders, blowing kisses and giving 'thumbs up' of
encouragement as the little ones nervously file on to the stage.
their silky heads adorned in tinsel and hastily ironed tea towels, and
with cardboard wings strapped on their backs (not to mention the odd
finger up a nostril and thumb in a mouth), they are achingly, almost
painfully sweet.
husband Pascal and I continue to look forward as I gnaw on my bottom
lip. I dare not catch his eye. If I do, I fear the tears I've been
holding back all evening will finally spill.
I do not have a child in that line-up. I'm not in this club, and I
cannot stress how dearly I wish I was. Unfortunately, I am a 41-year-old
childless woman who is painfully aware that time isn't on her side, yet
is desperate to be a mother.
five years of trying for a baby, and spending thousands and thousands
of pounds on various fertility treatments, I'm facing the prospect of
yet another childless Christmas.
was against my better judgment that I attended the play — this year, a
performance of The Nightmare Before Christmas.
However, adoration for
my eight-year-old niece Lola - the daughter of my younger sister, Jo -
won through.
I live in
France and only get to see her a handful of times throughout the year.
And my husband and I were in the UK anyway to visit my family and
deliver Christmas presents.
So when, during a family dinner the previous evening, my niece had asked me to attend, how could I have possibly refused?
As one very proud aunt, I'd even bought a little posy of roses to present to her after the curtain came down.
Before the play finished, however, I'm ashamed to admit that my emotions got the better of me and — rather than put myself through any more heartache — I thrust the flowers into my mum's arms, whispered our excuses and left.
She understood. Of course she did. She'd seen my tears all too often in the last few years. She gave my hand a loving squeeze as I stumbled past her and into the aisle.
Outside in the car, the tears spilled. Pascal held me while I sobbed.
'I am a 41-year-old childless woman who is painfully aware that time isn't on her side, yet is desperate to be a mother'
The year is nearly over and has passed in a blur of yet more heartache and disappointment - like the four before them. I've done everything possible in a bid to become a mother. I've undergone endless invasive examinations, taken a course of the fertility drug Clomid, and attempted - and failed - a round of IVF.
To add to my agony, I am acutely aware that had that round of IVF in March been successful, I would now be carrying a newborn baby. However hard I try to banish this thought from my mind, it returns to punish me.
For all that I've put my body and mind through, I still cling to the hope every 28 days that this surely is the month it'll be my turn to announce my miracle baby. Yet I am still to see a positive blue line on a pregnancy test.
How wonderful it would have been to come home this Christmas, laden with presents, and announce to my family — finally — that we have some happy news.
This has also been the year that countless girlfriends and family members have announced pregnancies and produced babies seemingly in the blink of an eye.
Of course, I've congratulated them and been the first to organise generous baby showers and splurge on gifts at Baby Gap.
I'm not one of those women who gets upset when they see their friends' babies' photographs on social media websites. Rather, I adore witnessing how my glamorous girlfriends are effortlessly morphing into adept mothers.
Yet at Christmas, I'm afraid, all bets are off.
Emotions: Samantha and her husband Pascal have spent years and thousands of pounds trying for a baby
In the last few weeks, I've smiled through gritted teeth at images of babies in Santa-themed baby-grows, taken a sharp breath while opening child-designed Christmas cards and counted to ten when I've received lists from well-meaning friends of what to buy for their children.
I know, I know — it isn't their fault.
Yet Christmas doesn't make life easy for women like me. In television adverts and on High Streets everywhere you look, it's forced down your throat that the festive season is — above all else — a time for children.
In the past I've adored playing the doting aunt and godmother, dispensing dozens of presents to my family's and friends' children.
I used to love hearing my mother chatting excitedly about how she'd taken her three grandchildren shopping in December in order for them to drop almighty hints about what they'd like Santa to bring.
'I've spent sleepless nights lying in bed wondering if it's all my fault, that I'm just paying the cost of leaving motherhood too late'
Yet earlier this month when she called to talk through the trip, there was an awkward silence. We both knew what the silence meant: will the day ever arrive when she can do the same with my children?
I'm the only one of my sisters to have struggled with trying for a baby — and as the eldest it's a bitter pill that's so much harder to swallow.
I've spent sleepless nights lying in bed wondering if it's all my fault, that I'm just paying the cost of leaving motherhood too late.
Maybe I shouldn't have spent my 20s and 30s working and playing so hard — but sadly the truth is that I never met the man I wanted to be the father of my children when my body was ready to have them.
When I fell in love with Pascal and we started trying for a baby I was 36: not young, admittedly, but not terribly old either. I genuinely assumed that just like my friends of a similar age, I'd get pregnant easily. It didn't happen.
Since then, December has taken on a painful resonance in our house. Anything can bring on tears.
This year, Pascal quite innocently mooted the idea that we forego the Christmas tree, suggesting - many would say not unreasonably - that there was little point spending hours digging out the decorations or hanging up garlands of fairy lights when there was only us to appreciate them.
Painful: Samantha is steeling herself for another round of IVF treatment
The tears fell, he apologised and the tree went up — but the sadness remained like a bruise.
I've studiously avoided all of the Christmas markets near my home, knowing full well they'll be dominated by children eager to see Father Christmas.
I'd feel like the Child Catcher in Chitty Chitty Bang Bang, walking through these swathes of children with no sweaty or mittened little hand in mine.
At a festive drinks party earlier this month, a casual acquaintance asked me when I was going to start trying for a baby, informing me: didn't I realise I was leaving it a bit late?
At any other time of the year, I'd have given such an intrusive question short, sharp shrift, yet I surprised myself by blubbing for hours afterwards.
And as a result of being unable to trust my emotions, I've barely left the house this December.
I did venture out at the weekend, assuming a visit to the local fruit- and-vegetable market would be a safe bet. How wrong I was. Within minutes, I happened upon a stall selling homemade baby clothes.
Pride of place was a hand-knitted jumper with sprigs of holly around each sleeve. It was as though time had stopped, and I just couldn't help myself — I picked it up and held the soft, lemon-coloured garment in my hands, allowing myself to imagine a tiny, soft, warm body inside it.
What I wouldn't give to have been able to have bought it and wrapped my own child in it.
After that, I took Pascal up on his offer to do the Christmas shopping — it's just too painful to be around so much child-focused jollity.
Yet even at home I can't escape the reminders. The majority of Christmas cards I've received are adorned with children and endearingly signed from the same children who have made them.
As a Catholic, I'm acutely aware of the religious aspect of Christmas — the celebration isn't all about gifts for children. Yet the true heart of Christmas, the birth of Jesus, is another reminder of what I don't have.
So this year will be a somewhat subdued Christmas for my husband and I. In fact, we've promised not to buy gifts for each other. But that's because we've been saving for the biggest gift we could possibly bestow on the other — another attempt at IVF.
I would happily forego presents for the rest of my life for the opportunity to become a mum.
So while the majority of our friends and family will be over-indulging, I'll be off alcohol and watching what I'm eating while faithfully following the times when I need to sniff the fertility drugs. I'm already stealing myself for the cocktail of medication with which I'll need to inject myself.
I know people will probably question my sanity but there is one children's present I have bought this year — for such is my faith that I'm going to be a mother. It's a little giraffe, a pretty little thing. He sits beside my computer during the day when I work. He makes me smile and gives me hope.
Next Christmas, I hope to present him to my son or daughter. And I don't want anything in return just - finally - to see him or her clutching it.
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Elevated platelet counts are a common finding in many cancer patients, including patients with ovarian cancer. Patients with ovarian cancer and thrombocytosis have a worse prognosis compared to patients with similar stages of cancer and normal platelet counts. We have shown that platelets promote proliferation of cancer cells both in vitro and in the murine models of ovarian cancer;and reducing platelet counts decreased the size of orthotopic tumor induced in mice by ovarian cancer cells. To identify the mechanisms of the growth- enhancing effect of platelets on cancer cells, we used blocking reagents against platelets in vitro, and found that platelet activation and release of TGF?1 are important for the proliferative effect of platelets on cancer cells. In this project, we will study the interaction between platelets and cancer cells in vivo, using both murine models of ovarian cancer and tissue samples obtained from patients with ovarian cancer. Our hypothesis is that there is a feedback loop between platelets and cancer cells. Cancer cells secrete ADP and activate platelets, and platelets secrete TGF?1 that promotes proliferation in cancer cells. In the specific aim 1, we will investigate whether blocking ADP receptors on platelets would disrupt the growth promoting effect of platelets on orthotopic tumors in mice, using genetically modified mice or pharmacologic reagents. In the specific aim 2, we will target TGF?1 secretion from platelets, TGF?1 receptor on cancer cells, or TGF?1 receptor signaling to evaluate the role of TGF?1 on the platelet-cancer cell interaction. We will use platelet-specific TGF?1 deficient mice, inhibitor RNAs, or pharmacologic reagents against TGF? receptor signaling to conduct these experiments. For the interaction between platelets and cancer cells to occur inside the tumors, platelets should exit circulation and enter into tumor microenvironment. We have shown the presence of platelets outside of blood vessel inside the implanted tumors in mice. In the specific aim 3, we will study the mechanisms of platelet exit from tumor microcirculation using immunofluorescence and electron microscopy on human and murine ovarian cancer tissue samples. We will identify the route of platelet extravasation, and evaluate the dependency of platelets on neutrophils for extravasation. The goal of our studies in this grant proposal is to evaluate the possibility of using anti-platelet reagents as an effective anticancer therapy.
Platelets promote growth and metastasis of malignant tumors. In this project, we will identify the mechanism of platelet involvement in tumor growth in murine models of ovarian cancer. We will investigate the effect of blocking the interaction between platelets and cancer cells, using available anti-platelet medications, on tumor progression with a long term goal to evaluate the usefulness of anti-platelet medications as an effective and relatively safe anti-cancer therapy.
|Bottsford-Miller, Justin; Choi, Hyun-Jin; Dalton, Heather J et al. (2015) Differential platelet levels affect response to taxane-based therapy in ovarian cancer. Clin Cancer Res 21:602-10
|Wen, Yunfei; Graybill, Whitney S; Previs, Rebecca A et al. (2015) Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Clin Cancer Res 21:448-59
|Previs, Rebecca A; Coleman, Robert L; Harris, Adrian L et al. (2015) Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. Clin Cancer Res 21:955-61
|Lin, Richard J; Afshar-Kharghan, Vahid; Schafer, Andrew I (2014) Paraneoplastic thrombocytosis: the secrets of tumor self-promotion. Blood 124:184-7
|Tucker, Susan L; Gharpure, Kshipra; Herbrich, Shelley M et al. (2014) Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer. Clin Cancer Res 20:3280-8
|Menter, David G; Tucker, Stephanie C; Kopetz, Scott et al. (2014) Platelets and cancer: a casual or causal relationship: revisited. Cancer Metastasis Rev 33:231-69
|Gharpure, Kshipra M; Chu, Kevin S; Bowerman, Charles J et al. (2014) Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer. Mol Cancer Ther 13:1750-7
|Wen, Yunfei; Zand, Behrouz; Ozpolat, Bulent et al. (2014) Antagonism of tumoral prolactin receptor promotes autophagy-related cell death. Cell Rep 7:488-500
|Rupaimoole, Rajesha; Wu, Sherry Y; Pradeep, Sunila et al. (2014) Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nat Commun 5:5202
|Cho, Min Soon; Vasquez, Hernan G; Rupaimoole, Rajesha et al. (2014) Autocrine effects of tumor-derived complement. Cell Rep 6:1085-95
Showing the most recent 10 out of 15 publications


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Man indicted in drive-by shooting
By JOHN BURNETT
Tribune-Herald staff writer
A 23-year-old Mountain View man faces numerous charges for allegedly endangering three people during a March drive-by shooting in Eden Roc subdivision.
A six-count indictment returned Wednesday by a Hilo grand jury charges Carl Andrew "Andy" Wright with two counts of first-degree terroristic threatening, three counts of first-degree reckless endangering and carrying a loaded firearm.
According to court documents filed by police, Rex Ventura, Randell Ventura and Sabrina Gonsalves told officers that on March 2 at about 4:15 p.m., they were standing outside their Mikana Street home when they saw a green Honda Civic sedan driven by Zedekiah Newberg burn rubber, drive past the house, then stop about 50 yards away.
An occupant in the vehicle then allegedly fired approximately eight shots in the direction of the three residents of the house, "causing them to fear for their lives," documents state. Several bullets were recovered from two of Gonsalves' vehicles, police said. Nobody was injured in the shooting.
Newberg, of Eden Roc, allegedly admitted to police that he was the driver of the car, but told officers that Wright, his housemate, was the one who fired the shots. He told officers that the firearm was a .22 caliber rifle, according to documents. He also reportedly identified Wright in a photographic line-up.
Newberg has not been charged with any offenses. Gonsalves and Rex Ventura filed for a temporary restraining order against Newberg on March 6, but their petition was dismissed on March 18 by Hilo
District Judge Andrew Wilson when none of the parties showed up for a hearing.
A warrant was issued for Wright's arrest and he was taken into custody on May 1. A preliminary hearing was held the following day, and Hilo District Judge Harry Freitas found probable cause to try Wright on three counts each of terroristic threatening and reckless endangering. He pleaded not guilty to those charges on May 16 before Hilo Circuit Judge Glenn Hara.
The indictment adds the firearms charge and drops one count of terroristic threatening. Wright will be re-arrested and arraigned on the updated charges. A bench warrant set his bail at $17,000, and Wright has been ordered to have no contact with the victims and to not possess firearms.
The firearms charge is a Class B felony carrying a possible 10-year prison term, while first-degree reckless endangering and first-degree terroristic threatening are both Class C felonies punishable by up to five years imprisonment.
Wright remains in custody in Hawaii Community Correctional Center.
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Ah, Clifton. My favorite neighborhood in the city (that isn't downtown). Where else can you see an indie flick and then chow down on your favorite ethnic food? Within a few blocks, you can get pizza, Mediterranean, Indian (four or five times over), Thai, sushi– you name it.
A couple of Champagne Tuesdays ago, a few of my friends and I went to Thai Cafe after discovering that Kaldi's kitchen now closes at 3 PM on weekdays– no more Tuesday Burger Madness! Sad.
Monika and I both ordered Thai dishes, while Lauren and Amy both got sushi. I have never eaten sushi there– I tend to go to sushi-focused restaurants for sushi– But both Lauren and Amy were really happy with their choices, which ranged from dragon rolls to eel, spicy to sweet.
Monika got tofu in coconut and yellow curry– not too spicy!
I got Pad Thai, level 1. I'm a wimp, I admit it. However, I do think that their pad thai is the best in the city– it's a little sweet, but not too sweet, and definitely savory; the chicken (my choice) is never overdone (some restaurants turn it to either rubbery bits or mealy bits, neither of which is appetizing), nor is the egg. The noodles are well coated in sauce, but not overly greasy (typical) or too wet. The most important thing? It's consistent. It is good every single time, from the service to the food– I have not had a bad meal there in all of the years I've been going there.
The prices are a little high compared to other fare directed at college kids in Clifton, but still very reasonable– my bill was right around $12 with a drink– a real steal, in my mind.
I love their Coconut soup – the best.
I appreciate it when Thai restaurants offer non-Thai food. I dislike Thai food and my boyfriend loves it. (I dislike coconut milk, peanuts in food, and other flavors used in Thai foods) I do eat vegetarian sushi though!! Thanks for the tip 🙂
I agree that they have one of the best Pad Thai's in the city… I love their house pad thai with both shrimp and chicken. The only one that rivals it is Wild Ginger!
Thai food is a food I have really been missing since my move out to Cinci… I've been to em all within 10 miles of my house. Not one is even close to "up to par". This is another one though where i bet my rankings of what is good and yours will be totally different. I like traditional pad thai, aka, street vendor style, the kind I could find in dozens of local places in Boston, yet not a one around here. The closest I've found is lemon grass in hyde park, but its still of way lower quality than I came to be used to in Boston. I guess I'll have to reserve good thai for travels out to see family.
Frankly, Thai Cafe… meh, never been thrilled (but from my perspective, thats all of the thai in Cincinnati)
I actually liked the pad thai at the 'nothing but noodles' place in kenwood. The best I ever had was in Rhode Island at a place called 'Galaxy'. It was in a dumpy ex fried fish restaurant.
o how i miss the thai cafe.
Closed 🙁


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Editor Profile
Deborah Lehman, MD
Associate Editor
About the NEJM Journal Watch Pediatrics Board
Deborah Lehman, MD, is Clinical Professor of Pediatrics at the David Geffen School of Medicine at the University of California, Los Angeles, and Associate Director of the Division of Pediatric Infectious Diseases at Cedars-Sinai Medical Center. At Cedars-Sinai, she also serves as Director of the Outpatient Pediatric Infectious Diseases Clinic, directs the residency and medical student infectious diseases education program, and serves as the pediatric clerkship site director for third-year medical students. She is the recipient of several teaching awards and has created a popular pediatric infectious diseases curriculum for rotating medical students and residents. Her special interests include congenital infections and medical education. Dr. Lehman joined the board of Journal Watch Pediatrics and Adolescent Medicine in 2013.
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Congenital Toxoplasmosis: Update on Diagnosis, Treatment, and Prevention
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Recurrent Throat Infections in Children: Surgery or Watchful Waiting?Free
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A systematic review finds that tonsillectomy provides some short-term benefits over watchful waiting for children with mild to moderate throat infections, but it's not clear if the benefits persist.
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The Covariance Structure of Earnings and Income, Compensatory Behavior, and On-the-Job Investments
The covariance between income and income growth for data from nineteenth-century Uta h is negative. An extended covariance model, estimated with earnings and income data, suggests that the degree of concavity of the age-ear nings (age-income) profile is associated with initial earnings (incom e) and the growth in earnings (income): those with lower initial earn ings (incomes) have higher rates of growth, but more concave age-rela ted profiles. These findings are consistent with a human capital inte rpretation of the earnings (income) profile and imply that there is m ore rapid depreciation of human capital obtained through on-the-job t raining than through other sources. Copyright 1988 by MIT Press.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
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Volume (Year): 70 (1988)
Issue (Month): 2 (May)
Pages: 214-223
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text:
From: John I Jones <email@example.com>
Patrick Orr wrote:
> From: "Patrick Orr" <email@example.com>
> Although it is typically thought that a virus causes such markings on
> irises, such is not the case with this cultivar. These marks are genetic
> and have been consistent since its maiden bloom prior to its introduction
> more than 11 years ago.
> ----- Original Message -----
> From: Harold Peters <firstname.lastname@example.com>
> To: <email@example.com>
> Sent: Tuesday, March 14, 2000 10:40 PM
> Subject: Re: [iris-photos] BLUSHING CHERRY
> > From: "Harold Peters" <email@example.com>
> >
> > I believe that the color marks on Blushing Cherry are virus marks and not
> > broken color. Virus marks are caused by a virus. Some plants are more
> > susceptible to virus marking than others. Weather conditions also seem to
> > be a significant factor is virus marking because there can be years where
> > there is no virus marking. My experience with virus marking comes from the
> > older arilbreds, many of which are susceptible to virus marking. I had a
> lot
> > of older arilbreds at one time. A hungry gopher got into the bed and
> totally
> > eliminated 45 of 57 clumps in the bed. My trapping technique were not
> > adequate to catch that gopher.
> >
> > Harold Peters
This thread has started on iris-photos, and I thought it would be good
to move it over to iris-talk. If you are interested in seeing the
picture , it is in the archives at:
My questions are:
Would it not be true that the virus would be passed on from increase to
increase? How does one tell the difference between a virus and a broken color?
John | "There be dragons here"
| Annotation used by ancient cartographers
| to indicate the edge of the known world.
USDA zone 8/9 (coastal, bay)
Fremont, California, USA
Visit my website at:
President, Westbay Iris Society
Director, Region 14 of the AIS
AIS Special Committee for Electronic Member Services
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Archives at: http://www.mallorn.com/lists/iris-talk/
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