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Marrakech, Beach & Beyond - 8 days
Spend 8 days exploring Morocco. From Marrakech explore Ouarzazate, take a camel ride into the Sahara, camp under the stars and discover fascinating Ait Benhaddou. Finish off with two nights of beach side bliss in coastal Essaouira before returning to Marrakech.
Welcome to Morocco! Upon arrival at Marrakech International Airport you will be met and transferred to your hotel. Why not relax by the pool before the pre-departure meeting at 18.00 where you will meet your fellow travellers.
Overnight: Marrakech
After breakfast we head south to the film capital of North Africa - Ouarzazate. After a local lunch we have the chance to take an optional tour of the film studios -
famous for many blockbusters including Gladiators, The Last Temptation of Christ and James Bond's - The Living Daylights! We can also opt to go quad biking and further explore the town.
Overnight: Ouarzazate | Breakfast, Lunch, Dinner
Into the Sahara
This morning we take a stunning drive towards Erg Chebbi, stopping by a 14th century irrigation well and intricate network of canals on the way where we learn how the wells are made. Later we stop for a fantastic Moroccan lunch and relaxing swim. Afterwards we head to Merzouga before transfering to our camels for a trek into the Sahara. We spend the night at our traditional Berber Camp. We enjoy local food, music and an amazing night out under the Saharan stars.
Overnight: Erg Chebbi | Breakfast, Lunch, Dinner
Todra Gorge & Ait Benhaddou
After a tasty breakfast in the Sahara we climb back on board our trusty camels and head out of the Sahara. Once out of the sand we get back on the road for a lunch stop at Todra Gorge. This 1000ft gorge is hemmed in on all sides by vertical limestone cliffs and is also called Morocco's Grand Canyon. In the afternoon we continue to famous Ait Benhaddou. One of Morocco's most famous UNESCO World Heritage sites boasts great examples of Kasbahs, some of which remain inhabited.
Overnight: Ait Benhaddou | Breakfast, Lunch, Dinner
Today is a free day to explore Essaouira, this colourful fishing town dating back to the 15th century when the Portuguese forst fortified it has great beaches and fantastic surfing. You can relax on the beach or if you fancy getting out and about then explore the UNESCO-listed medina with its various souks and woodcarving workshops. All of the city gates lead to the medina, so it's unlikely you will get lost.
The beach sits in front of the Medina and there are a plethora of cafés with terraces, both ideal for relaxing for a few hours. Blue doors and window frames abound as do the artists' shops – buy a carpet or Thuya wood carving or sit on the beach sipping a mint tea as the sun sets. There is also the opportunity to do some optional activities, such as quad biking, surfing, horse trekking and wind surfing or you can just simply sit on the beach and relax!
Overnight: Essaouira | Breakfast
Back to Marrakech
After breakfast we return to our hotel in Marrakech for our final night. Once here, we will get some free time to relax at the hotel before we start our guided city tour late this afternoon. We end the day our last group meal in the famous Djemaa El Fna, the legendary main square full of acrobats, snake charmers, juice sellers and various al fresco restaurants.
Overnight: Marrakech | Breakfast, Dinner
Our tour ends after breakfast with check out at the hotel.
Prices shown are per person travelling. 'Twin/Double' prices per person apply when there are 2 people travelling, sharing a room. The 'Single supplement' applies for single travellers who require their own room and needs to be added to the 'Twin/Double' price. If you are happy to be paired up with another single traveller of the same sex on your tour, this can be arranged, thus avoiding the single person supplement.
Departure dates noted with a 'G' are guaranteed to operate. All other departure dates are guaranteed with a minimum of 2 persons.
Supplementary Prices
The hotels listed below are ones which we frequently use on this tour. We reserve the right to substitute these hotels to ones of a similar standard when necessary.
El Andalous Hotel & Spa, Marrakech
Just 10 minutes from the airport, the El Andalous Hotel and Spa offers a welcome respite from the hubub of the city. Evoking the golden age of Arab-Andalusian culture; exotic and romantically rich. Guest rooms are well furnished with excellent en suite facilites as well as private balconies. The hotel pool is great place to relax by and enjoy a tasty beverage or two. The medina is just a 20 minute walk from here or a cab can get you there in a few minutes!
Les Jardins , Ouarzazate
A fairly new hotel in Ouarzazate, the Hotel les Jardins is in the traditional style of a Moroccan kasbah, with spacious rooms. The hotel is set in exquisitely manicured gardens, which provide guests with a much needed breath of fresh air. The experience is complete with a pool and restaurant, where visitors can while away the hours in the warm, starry evenings. The hotel is on the outskirts of Ouzarzate and has numerous restaurants and shops nearby.
Desert Camp, Erg Chebbi
Camping out in the Sahara Desert is an incredible experience, enabling you to sit on top of a dune to watch the setting sun, sit around a camp fire for dinner and lie back and see the stars. No alcohol.
Hotel Miramar, Essaouira
Enjoying an enviable location just a 15-minute walk from the beach and some of the city's key sights, Hotel Miramar combines 4-star comfort with local convenience. Each of the 45 guest rooms' benefit from a separate sitting area, room service and satellite television, there's also free WiFi throughout the property. After a day of sightseeing guests can unwind in the on-site spa, which offers a variety of treatments, or those that prefer to relax during the day can opt to head to the hotel's private sand beach.
Trip Highlights
Not Included
I hope I have spelt his name correctly as I saw it only once,this guy bent over backwards to help our group with anything we asked for,no task to big and with such enthusiasm and always a smile and a joke he certainly made me feel at home in Morocco,also a great big thanks to our driver,Moroccan roads and there drivers need a second sense about them to navigate the busy bustling roads and he did it incredibly. A big THANKS to all at On The Go. ."
The tour was awesome! We got to see places and meet people that you just can't see with the larger tour operators. We had a nice small group of 8 people which was perfect. Our guide Brahim was brilliant. His knowledge and professionalism was second to none. Everything went smoothly and we saw some amazing sites, met some awesome people and had some incredible experiences! Also our driver Mohamed was fantastic too! Everything was perfect and can't recommend it enough! Thank you! "
Thank you so much for all the work and bookings you did for my holiday in Morocco.
We had an absolutely amazing time and I would definitely recommend On The Go Tours. Our guide in Morocco, Ibrahim was fantastic - his passion and knowledge about Morocco was amazing and he really went out of his way to ensure we all have a great time. "
Excellent, action packed tour - whole family thoroughly enjoyed the trip - Mustapha our guide was great and coped well with dealing with missing luggage and an injury sustained by one of our fellow travellers as well as keeping us entertained and ensuring we all kept to our schedule. Very well organised tour with good accommodation and plentiful food - in fact 2 x 3 course meals a day (as well as breakfast) could be deemed as a bit too much! "
The tour was amazing. I always choose On-the Go tours because they always provide a good standard of hotel, meals included and most importantly good quality guides who know the land, the history, culture and people well. I have had bad tour guides and good tours guides and Ibrihim was amazing! "
Ibrahim has taken good care of all of us, a group of 15 people with different cultural background. He has proven knowledgeable about the Morocco sites we visited and was able to provide a good mix of activities ranging from sports, to leisure to cultural. What I liked the most was his passion for his country and the attention to the group safety and needs. We experinced the "real Morocco" by visiting local markets and real vilages. Th ehighlight was the guided tour of the desert on camels and the hotair baloon extra activity. All details were taken care of and we always felt he was in charge and did it with kindness and fun. I woudl recommend him as a tour guide anytime.
I woudl rate Ibrahim at the top of the score as well as the tour that he designed. We had atrue feel of what Morocco is like in Marrakech. "
The tour was really great. Mustapha was a really informative, happy and personable guide. He is a tribute to your company. Our driver was fabulous. I felt completely safe the whole time and comfortable. I really enjoyed this tour and would not hesitate to recommend it to others. Thank for such a great experience."
This trip has been a wonderful experience. Morocco is an amazing country and Brahim has been an excellent tour guide."
Great tour, great guide. Thank you. "
Dear Charlie,
I had a wonderful time the Marrakech and Beyond Tour. Brahim was so well spoken and helpful! Definitely booking another tour in the future. "
Active Days, Rustic Nights
I hope I have spelt his name correctly as I saw it only once,this guy bent over backwards to help our group with anything we asked for,no task to big and with such enthusiasm and always a smile and a joke he certainly made me feel at home in Morocco,also a great big thanks to our driver,Moroccan roads and there drivers need a second sense about them to navigate the busy bustling roads and he did it incredibly. A big THANKS to all at On The Go. ."
Our OTG Adventure takes you to the true heart of adventurous destinations. Whether camping in the Okavango Delta, staying in rustic accommodation in the Peruvian Amazon or camping under the Saharan stars in Morocco, this range forsakes just a little bit of the comfort of OTG Signature Range, ensuring we deliver you the best value possible for your holiday.
OTG Adventure takes you straight into the centre of where it's all at, typically using local transport or overland style vehicles and stay at simple, clean and locally-owned guest houses, haciendas, eco-lodges and simple hotels to maximize the opportunity to interact with the locals.
For all our tours and tailor-made holidays we provide you with a clear categorisation of all hotels we use. The REGIONAL CATEGORY indicates the local rating of each hotel in each respective country. We have also rated each hotel using OUR CATEGORY, which will be in line with generally accepted western hotel grading standards.
Basic hotels and simple accommodation is a no frills option with an adventurous authentic feel.
Standard accommodation equates to a Western 3-star standard, always featuring en-suite rooms and usually a restaurant.
Superior accommodation equates to a Western 4-star standard, featuring en-suite rooms and usually a restaurant and often a swimming pool and/or a fitness centre.
Deluxe accommodation equates to a Western 5-star standard, usually featuring spacious, en-suite rooms, a restaurant, swimming pool and fitness centre and an array of amenities, excellent service and customer care.
Lavish accommodation equates to a Western 5-star plus standard - the creme de la creme. Featuring spacious, en-suite rooms, a restaurant, swimming pool and fitness centre and an array of amenities, this accommodation is a cut above the rest. Sheer opulence!
Tipping Kitty
Tipping is not a natural part of many Western cultures and many of us feel uncomfortable, or unsure, about when, or how much, to tip. However, in Morocco, tipping makes up a significant part of many people's wages so it's important that we get it right. For this reason we've developed a very simple system to take all the hassle out of tipping. With our 'tipping made easy' policy, a nominal pre-determined amount is collected from all group tour participants to cover tips en route. This then saves you the hassle of when and how much to tip bellhops, luggage handlers, local guides and other support staff through the tour. Our 'tipping made easy' doesn't include a tip to your group tour leader. Naturally, though, the amount is up to you as tipping is an entirely personal gesture.


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Examples of actors on this list: Matt Damon, Ben Affleck and more.
If you want to answer the questions, "Who starred in the movie Field of Dreams?" and "What is the full cast list of Field of Dreams?" then this page has got you covered.
This cast list of who was in Field of Dreams includes both lead and minor roles. (53 items)
- 1
Ben Affleck Dazed and Confused, Good Will Hunting, Field of Dreams
- 2
Kevin Costner Dances with Wolves, Man of Steel, Field of Dreams
- 3
Matt Damon Saving Private Ryan, The Departed, Good Will Hunting
- 4
James Earl Jones Star Wars, Star Wars Episode V: The Empire Strikes Back, The Lion King
- 5
Burt Lancaster Field of Dreams, From Here to Eternity, Judgment at Nuremberg
- 6
Ray Liotta Goodfellas, Field of Dreams, Identity
- 7
Frank Whaley Pulp Fiction, Field of Dreams, Red Dragon
- 8
Art LaFleur Field of Dreams, WarGames, The Replacements
- 9
Timothy Busfield Field of Dreams, Stripes, Revenge of the Nerds
- 10
Amy Madigan Field of Dreams, Uncle Buck, Gone Baby Gone
- 11
Lee Garlington Field of Dreams, American Pie 2, Some Kind of Wonderful
- 12
Gaby Hoffmann Field of Dreams, Sleepless in Seattle, Uncle Buck
- 13
Michael Milhoan Field of Dreams, Pearl Harbor, The Lost World: Jurassic Park
- 14
Kelly Coffield Park Field of Dreams, Jerry Maguire, Bride Wars
- 15
Steve Eastin Field of Dreams, Austin Powers: The Spy Who Shagged Me, Catch Me If You ...
- 16
Anne Seymour Field of Dreams, Big Top Pee-wee, Pollyanna
- 17
Mike Nussbaum Men in Black, Field of Dreams, Fatal Attraction
- 18
Larry Brandenburg The Shawshank Redemption, Fargo, Field of Dreams
- 19
Dwier Brown Field of Dreams, Red Dragon, The Cutting Edge
- 20
Geoffrey Nauffts Field of Dreams, A Few Good Men, Unfaithful
- 21
James Andelin Field of Dreams, Stir of Echoes, The Babe
- 22
Fern Persons Field of Dreams, Hoosiers, Risky Business
- 23
Robert Kurcz Field of Dreams, Risky Business, Payback
- 24
Howard Sherf Field of Dreams
- 25
Charles Hoyes Field of Dreams, Space Jam, Brush with Death
- 26
Joseph R. Ryan Field of Dreams, Primal Fear, Next of Kin
- 27
Kevin Fennessy Field of Dreams, The Witches of Eastwick, The Verdict
- 28
Brian Frankish Field of Dreams, The Net
- 29
Brian Waldvogel Field of Dreams
- 30
Beatrice Fredman Field of Dreams, Four Friends
- 31
Don John Ross Field of Dreams
- 32
Dale Till Field of Dreams
- 33
Jeffrey Neal Silverman Field of Dreams
- 34
Jude Milbert Field of Dreams
- 35
Jim Doty Field of Dreams
- 36
James Roth Field of Dreams
- 37
Steve Olberding Field of Dreams
- 38
Joe Glasberg Field of Dreams
- 39
Mark Danker Field of Dreams
- 40
Ron Lucas Field of Dreams
- 41
Mary McDonald Gershon Field of Dreams
- 42
Jay Hemond Field of Dreams
- 43
Fred Martin Field of Dreams
- 44
Curt McWilliams Field of Dreams
- 45
Mike Goad Field of Dreams
- 46
Steve Jenkins Field of Dreams
- 47
Frank Dardis Field of Dreams
- 48
Mike Hodge Field of Dreams
- 49
Terry Kelleher Field of Dreams
- 50
Gene Potts Field of Dreams

subset: commoncrawl


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Miller & Chevalier held Part II of an invitation-only teleconference to provide an inside-the-beltway perspective on health reform and the issues that are likely to create significant implementation issues for companies.
The coming months represent a critical period for U.S. businesses with respect to health care policy changes. Congress has very high expectations for what employers can deliver, which could place a significant burden on businesses. In addition, as Congress begins to focus on paying for reform, a number of tax provisions unrelated to health care are now in play. The purpose of the teleconference series is to provide timely information about the status and strategy for reform, and to share our insight regarding the provisions most likely to impact our clients from an implementation/compliance perspective. As part of Miller & Chevalier's ongoing effort to keep a finger on the pulse of the issues that are important to our clients and the business community at large, we just completed our second annual survey designed to measure the perspectives and attitudes of leading corporate benefits executives on the direction of health care policy in the coming months.


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Yes, Clyde I would and in any discussion about ID, color, shape, etc it
would be helpful to have that kind of reference. It wouldn't answer every
question but it would be very helpful.
>I have jpeg. files of both, if anyone would like to see them.
>Clyde Crockett z5
Butch Ragland So. Indiana zone 5
"Conflict is as addictive as nicotine, alcohol, drugs, etc.
I'm sorry to report that cooperation is not."
To sign-off this list, send email to firstname.lastname@example.com with the
message text UNSUBSCRIBE HOSTA-OPEN


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Wednesday, June 5, 2013
Vigilent Finds More Funding For Data Center Cooling
El Cerrito-based Vigilent, which develops building energy management systems, said Tuesday that it has raised a new round of funding. Size of the round was not disclosed. The firm said the funding came from TELUS Ventures. The firm's energy management sytsem use wireless sensors, data center analysis, and more to optimize air cooling in those data centers. More information »


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Últimos Descuentos de Negocios en Foursquare Panamá Agosto-Septiembre 2011
Escrito el17. Ago, 2011 por PabloMetal in Variedad
Ya era hora que en Panamá los comercios vieran en Foursquare como una forma viable de atraer nuevos clientes y promocionar sus negocios, Las ofertas disponibles de algunos comercios panameños quienes ya forma parte de la red social foursquare cada vez aumenta y esto nos beneficia a todos nosotros como clientes.
Aquí les dejo una lista de los últimos negocios que he visto que ofrecen desde descuentos, cenas gratis, Agrandados de combos, 1 dia de gimnasio gratis, ingredientes extras en tu pizza y mucho más!
Para poder recibir estos descuentos solo tienes que tener una cuenta de foursquare, tu Móvil, la aplicación de Foursquare instalada en tu móvil, y hacer Check-in cuando este en el negocio, y mostrarle tu check-in en la pantalla de tu móvil a la persona que te está atendiendo en el local comercial y listo.
Estas son algunas de las ofertas para Agosto y Septiembre 2011
Sony Style – Multiplaza Pacific, metroMall
Recibe 5% de descuento en tu compra
Taco Bell – Mall Multiplaza Pacific, El dorado, Albrook mall, Villa lucre, metromall
Compra un combo y hazlo grande GRATIS con tu Check-in
valido hasta el 31 de Agosto,2011
RockBurger – Calle 50, Costa del Este
Una orden de Papitas y una galleta de cualquier sabor Gratis al hacer check In con un consumo mínimo de $7
Loquierelotienes– Ave.Central España, Villa Lucre
Recibe 15% de descuento al ser cliente frecuente
KFC – El dorado, San francisco, transismica y 12 de octubre
Agranda tu combo Gratis haciendo check-in
valido hasta el 31 de Agosto,2011
Pizza Hut – San francisco, Campo Lindbergh, Plaza Villa Lucre, Los Pueblos, metromall, Aeropuerto Commercial Park
Puedes escoger un ingrediente extra a tu pizza GRATIS, puedes escoger entre pimientos, aceitunas, piña y queso
Valido hasta el 18 de Septiembre 2011-08-17
Burnedit Fitness Center – Centro comercial los tucanes, El Dorado
una clase para ejercitar tu cuerpo GRATIS!
Casco Station – Casco Viejo
Tu primer día en el CastoStation es gratis al hacer ckeck-in y al MAYOR le regalan Free parking
Temas Relacionados
8 Comentarios
04. Nov, 2011
Gracias por descubrirnos, Pablo!
Éxito en todo y los esparamos pronto en el gimnasio!
Visitanos también Pablo!
11. Dic, 2011
Foursquare, siempre se me ha hecho interesante, como usuario, en especial los descuentos que luego te encuentras por las calles xD.
29. Oct, 2015
Hace tiempo que ricebo el cate1logo de Laura Ashley cada temporada ,me encanta ojearlo de vez en cuando,sus telas y papeles pintados,sus le1mparas y sus sofe1s…todo tan britsh como dirias tfa…nunca se me ocurrif3 entrar en su pe1gina web pero ahora mismo lo voy a hacer…gracias
30. Mar, 2016
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02. Abr, 2016
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06. Abr, 2016
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14. Abr, 2016
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14. Abr, 2016
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ORLANDO, Fla. -- In the end, one major league general manager speculated Tuesday, whether Victor Martinez returns to the Boston Red Sox will probably depend on whether the team is willing to give the free-agent catcher a four-year deal, and he doubts the Sox are.
Regardless, Red Sox GM Theo Epstein gave the strongest sign to date that the team would be willing to go into the 2011 season with Jarrod Saltalamacchia, the only catcher with big league experience on the roster, as its No. 1 catcher.
Epstein's endorsement of Saltalamacchia on Tuesday dovetailed with reports that the Florida Marlins were about to sign free-agent catcher John Buck, who projected as the second-best option to Martinez on the market. The Red Sox liked Buck, according to league sources, but not at the price -- a reported three-year deal in the $15 million-$16 million range -- that the Marlins evidently are willing to pay for him. The Sox anticipated Buck's price would reach a range they weren't willing to enter.
Asked whether he would be comfortable with Saltalamacchia opening the season as the No. 1 catcher, Epstein said:
"We'll probably have a more experienced guy than him on the roster as well, but I think we're comfortable with him in a role anywhere from backup to job share to everyday guy, depending on how the rest of the club shapes up," Epstein said. "We like him. Obviously we liked him from a scouting standpoint. We took an opportunity to buy low after he'd been through a rough period.
"He really impressed the staff, which had no vested interest in it. He really opened some eyes, from the manager [Terry Francona] to [catching instructor and bullpen coach] Gary Tuck to the pitching coach. The way he handled the pitchers, the way he threw, the way he conducted himself in the clubhouse, he was impressive to everybody.
"At some point you've got to give a chance to young players, let them build value, and he's one of those guys. [Jed] Lowrie is potentially another. [Ryan] Kalish is potentially another. We're not going to have high-profile solutions to all our needs, so it's good to have those alternatives you can turn to."
Epstein's mentioning of Lowrie and Kalish also is notable within the context of the potential loss of free-agent third baseman Adrian Beltre and the possibility that the team will not sign one of the two elite free-agent outfielders, Carl Crawford and Jayson Werth. Lowrie could become a candidate to be the everyday third baseman, while Kalish could bid for an everyday outfield job.
It would seem unlikely the Red Sox are prepared to give all three positions to relatively untested newcomers, but Saltalamacchia is sounding like the best bet of the three.
"Yeah, you may be taking an educated gamble," Epstein said, "but you're also potentially building a lot of value in those guys, giving them an opportunity to put themselves in the core we're developing.
"It's a little harder to do at catcher sometimes, unless that player has the attributes you're looking for: a catcher who cares about his pitching staff, can call a good game, and works hard and prepares. He does fit that criteria. Obviously, he's coming off the surgery [to repair a torn ulnar collateral ligament in his left thumb], which makes it a little risky. But he hits right-handed pitching at this point better than left-handed pitching, which makes it easier to find a complement. There are more right-handed-hitting catchers out there. We'll see what evolves."
Among the right-handed-hitting catchers available as free agents are veterans Yorvit Torrealba, Rod Barajas, Gerald Laird, Jason LaRue and Miguel Olivo. The Sox also could explore trade possibilities; the Pirates' switch-hitting Ryan Doumit and the Dodgers' Russell Martin have been mentioned as possible targets.
Seven or eight clubs are interested in Martinez, according to one baseball source, including the Red Sox, who have not been especially aggressive in their pursuit. The Detroit Tigers, who are seeking a middle-of-the-order bat and a complement to young catcher Alex Avila, have significant interest in Martinez, who could also DH and play some first base, but they're hardly alone. Texas and Baltimore have been identified as other potentially strong suitors.
Beltre's agent, Scott Boras, was here, with one baseball source saying Beltre was commanding significant interest even from clubs that typically don't spend big on free agents. One GM said his club was not in the market for Beltre because he believes the third baseman prefers a West Coast team. The Angels are believed to have strong interest in Beltre, but they're also expected to be big players for Crawford, and it remains to be seen whether they could afford both.
That could be a scenario, one GM said, in which Beltre could wind up back with the Red Sox, especially if no other West Coast team steps up. The Athletics made a run at Beltre last winter but he turned them down, even though they offered more money, and there has been some speculation that the Mariners, who did not re-sign Beltre last winter, would take another go at him, although Beltre's performance offensively suffered in Safeco Field.
Gordon Edes covers the Red Sox for ESPNBoston.com. Follow him on Twitter.


text:
By Will Carless |
Over the next couple of weeks, I'm going to be checking in on a few of the stories I've covered over the last year or so.
The idea is to keep an eye on these issues. I want to check on the promises that were made by public officials and agencies, and I want to keep the pressure on, making sure that the promised reforms or actions actually end up happening.
First up, let's take a look at California's affordable housing industry.


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post #1 of 10 Old 09-20-2012, 09:45 PM Thread Starter
what is best way to pre-treat mopani wood...
Before adding to aquarium. I'm trying to minimize the tannins as much as possible. Just wondering what best method is. This will be my first piece of wood.
post #2 of 10 Old 09-21-2012, 12:24 AM
If it's small enough you can boil it. Do this for a while empty the water frequently so you can tell when the tannins are reduced.
post #3 of 10 Old 09-21-2012, 12:26 AM
Originally Posted by dave56 View Post
If it's small enough you can boil it. Do this for a while empty the water frequently so you can tell when the tannins are reduced.
post #4 of 10 Old 09-21-2012, 12:29 AM
Originally Posted by Sanguinefox View Post
Want to build up on this. After you seem to see a tannin reduction and it appears to boil clear it doesn't hurt to go ahead and put in something to soak in water for a few days just to be sure that it all leaches out. If you got the time it's worth it.
post #5 of 10 Old 09-21-2012, 08:24 AM
Agree with what has been said already just wanted to throw this out there. Tannins is not the only thing you need to watch for with this wood. Though tannins are not bad or harmful to the fish. Fungus is a BIG issue with the wood. You can boil the crap out of this wood to get the tannins out but still sometimes get fungus to develop. This is the only wood I can buy locally so have dealt with it on numerous occasions. Most of the time I will boil it if small enough. Then use a steel wire brush on it. Then repeat a couple of times. Sometimes it works at gettting the fungus to stop sometimes not. I have done the process and thought the wood was fine and then a couple of weeks later after being in the tank it develops fungus and I have to take it out and do it all over again. Just something to watch.
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post #6 of 10 Old 09-21-2012, 08:56 AM
+1 on the fungus. I refuse to use Mopani anymore because of it. I could never get it to go away completely and finally decided it wasn't worth the risk.
Animal testing is a terrible idea; they get all nervous and give the wrong answers.
post #7 of 10 Old 09-21-2012, 09:42 AM Thread Starter
If mopani has such an issue with fungus, what would be a better/safe piece of wood I can use?
post #8 of 10 Old 09-21-2012, 10:13 AM
Malaysian driftwood is a good alternative. You can find some really interesting/unusual pieces.
Do the same as far as boiling and soaking to release tannins before adding to your tank.
Do the same as far as boiling and soaking to release tannins before adding to your tank.
Animal testing is a terrible idea; they get all nervous and give the wrong answers.
post #9 of 10 Old 09-21-2012, 12:49 PM
+1 Malaysian driftwood is much much better if you can get it. It has far less tannins in it then mopani wood. I have also not heard of ppl having issue with fungus with this wood.
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post #10 of 10 Old 09-23-2012, 12:33 PM
Has anyone ever rried hydrogen peroxide, ammonia, or bleach to treat the wood?
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text: How Long Can You Make Eye Contact Before Shit Gets Weird?Michael Nunez7/06/16 11:11am1045EditPromoteGo to permalinkYou can determine a lot by looking into a person's eyes. For years, scientists have studied how eye contact builds trust and if it reveals whether someone is lying. Now, a new study published in the Royal Society Open Science today examines exactly how long we prefer to look someone in the eyes.


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In a revealing communications experiment, a large group of trainees received elaborate instructions on how to arrange five dominoes in a certain pattern. The trainees were not allowed to ask the instructor any questions.
From engineering and product perspectives, the characteristics of plastics for automotive applications that Dr. Michael M. Fisher, director, Technology, American Plastics Council (APC; Arlington, VA), cites are interesting and impressive
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Property Details
Condo, 3 Bedrooms, 1 Baths, 8 Sleeps
Vacation Rental Description - FREE PRIVATE PARKING - CONTACT FOR SPECIAL DEALS!
**$100.00 DISCOUNT IF BOOK RESERVATION FOR 1 WEEK (7 nights) **
*Master bed room - 1 queen bed, color cable TV, DVD player, alarm clock,dresser ceiling fan
**2nd bedroom - queen bed, dresser, color cable TV, alarm clock, ceiling fan
**3rd bedroom - 2 twin beds, dresser, color cable TV, DVD player, alarm clock, ceiling fan
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**Dining room table w/6 chairs
**Pillows, comforters, mattress pads - please bring your own towels, sheets, and paper products. (bedding provided upon request)
**Beautifully decorated cottage style with gingham & floral
**Central air conditioning & heat
** Pack &;N Play - Playpen
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so you are sure to have a spotlessly cleaned home for you and your
family. The carpets, sofa and love seat have been professionally
cleaned for the 2015 season. We work hard in the off season to
prepare the condo so you may enjoy your time in Wildwood. This condo
has been successfully rented for the past seven summers. If you have a
special request please ask.
Recent Review
Great location and everything that you need
About the Owner
10 Reviews
5/5 -
(10 traveler reviews)
Great location and everything that you need
This condo is located in a very good location. The boardwalk is very close, Macks Pizza and the fudge shop around the block on the boardwalk along with Moreys. The Baker Ave beach is a really good spot. The condo was exactly as pictured, so many things provided so you can cook if you want to, relaxing is easy. Beach chairs and toys provided. The condo is very comfortable with front and back porch, and bike rack to store your bikes. Everything as described and more. Also, very helpful to have the washer/dryer in the condo. A/C was nice and cold for a very hot week.
Unbelievable very nice and very accommodating
We arrived at the condo Saturday afternoon. The condo is exactly what the pictures show very clean very beautiful very spacious. When we arrive back Saturday evening from being on the boardwalk we noticed the air conditioning was not working this was around 10 p.m. we called Ray the owner he contacted his wife and they were here first thing Sunday morning fixing the air conditioning. It is now 11:30 a.m. Sunday morning the air conditioning is running beautifully and thank you Sharon and Ray for being very speedy and fixing it.
I will write another review on the rest of our week at the condo. This is surely the place to stay if you come to the Wildwoods
Close & Convenient to WW Convention Center & Beach
We've been traveling to Wildwood for many years to attend the TIA Competition. This is the first year we've rented a condo. It was the best decision we have ever made! The condo was clean when we arrived and Sharon was terrific to work with. There were many things stocked in the cupboards and there is a washer/dryer in the unit. This was extremely helpful! The condo is close to the Convention Center, Beach, Boardwalk, and many stores and restaurants. We look forward to booking again next year!
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A beautiful getaway
We are so pleased with our stay here this summer. We have been coming to this place couple times now and every time it's always an enjoyable vacation. Everything was perfect - an extremely helpful owners, great location, beauty of the home itself - we had a blast. We would recommend this home to anyone, and I call it home because it feels this way when you're here.
Nice place for vacation
The condo met all our expectations. We found there everything we need for the stay and the beach. We had a great vacation with our 3 boys.
Thanks Ray, Sharon and John for the hospitality!
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Activity and Interests
Rental rates are for 8 people, including all children. Rates are subject
to change until lease is executed. In order to maintain our family atmosphere
there will be no prom, senior or group rentals. Please do not inquire for group
rentals. Thank you.
All rental agreements will have a refundable security deposit of $250.00.
Please be advised that this is a non smoking unit, you may however smoke outside
on the porch. Now accepting reservations for the 2014 season, book early !
Rates & Availability
Rental rates
Additional information about rental rates
|Refundable damage deposit
Our Home is Comfortable, Cozy and Spotlessly Clean. Great Location. Free Private Parking for Two Vehicles. Please don't hesitate to call us with specific questions or needs. firstname.lastname@example.com
40% deposit to reserve and balance of payment 30 days prior to arrival
payment by money order or certified bank check payable to: Sharon Keller
- 12
- Available arrival
- 12
- Available stay (no arrival)
- 12
- Unavailable
Property Type
- condo
- Adventure
- Family
- Historic
- Tourist Attractions
- Air Conditioning
- Clothes Dryer
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- Heating
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- Linens Provided ...
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- Parking ...
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Belfast United Methodist Church
Wednesday, February 22, 2017
The mission of the Belfast United Methodist Church is to be a community of Disciples in service for Jesus Christ, sharing God's love with all.
Free Community Supper
FREE Community Suppers
With a true sense of hearing the voice of God, a new vision for our church suppers was realized. The family of faith began serving Free suppers to the people of the community in 2015 and will continue this ministrry ion 2016. Join in our celebration of God's loving kindness. We want to pass it on!
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text:
The avant-garde is 40 years old
The Santarcangelo Festival has a mission: to leave its spectators lost for words, and research, as it is no mere showcase
The Festival of Santarcangelo, this year
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The Festival closes with a performance by Filippo Timi.
(In the picture: "My name is I love you", Fai Fai)
Emanuela Giampaoli, from Vogue Italia, July 2010 (n. 719), p. 18
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A chat with Kristin Prim, the founder of The Provocateur, the site that publishes letters written expressely by leading women addressing the whole female world. Vogue.it presents you an exclusive preview of the letter written by Dresden Dolls' Amanda Palmer
Fashion shows are changing: Burberry and all that's new on the runways
Menswear and womenswear collections will walk together and will be on sale right after the show. These are the news from Burberry but the evolution is generalized: runway shows are changing


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Sauteed Cherry Tomatoes
|Cherry tomatoes
|1 Pint
|Garlic clove
|1 Large
|Chopped parsley
|3 Tablespoon
|Olive oil
|2 Tablespoon
|Bread crumbs
|1 1⁄2 Cup (24 tbs) (White Or Whole Wheat)
|To Taste
|Freshly ground black pepper
|To Taste
1)Wash and stem tomatoes.
2)Put garlic through press and chop parsley.
3)After heating oil in a skillet, add tomatoes, garlic, parsley, bread crumbs, salt and pepper.
4)Saute over low heat stirring occasionally, about 15 or 20 minutes, until tomatoes begin to soften and also not letting the crumbs to burn.
5)Serve it hot.
Recipe Summary
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Nutrition Rank
Nutrition Facts
Serving size
Calories 145 Calories from Fat 72
% Daily Value*
Total Fat 8 g12.5%
Saturated Fat 1.2 g5.9%
Trans Fat 0 g
Cholesterol 0 mg
Sodium 275 mg11.5%
Total Carbohydrates 15 g5.1%
Dietary Fiber 1.8 g7.2%
Sugars 4.6 g
Protein 3 g5.3%
Vitamin A 33.1% Vitamin C 58.4%
Calcium 6.3% Iron 8.1%
*Based on a 2000 Calorie diet


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Cousins Subs Systems, Inc. recently announced the opening of its new store located on South Church Street in Watertown, Wis. The store will officially open June 25 and is owned by Gerry Arnholt, who joined Cousins after being the general manager of a large automobile dealership for 16 years.
'When I was growing up, my family owned a wholesale bakery and we made breads from scratch,' added Arnholt. 'So I am very excited to be working with Cousins Subs and their high-quality breads that are baked daily.'
'We are thrilled Gerry will be opening his first store with Cousins,' said Kerry Espich, manager of franchise sales and recruitment for Cousins Subs. 'He will be an integral part of the Cousins Subs team, and we look forward to the new store's success.'
This store will be one of Cousins' first restaurants to feature the national sub-chain's newest designs and features including stained concrete floors and flat screen televisions tuned to news and sports for customers to enjoy.


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Academic essay writer required.
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We are looking for several writers who can start with us starting from March. We are looking for writers that can work 1-2 projects daily. Projects include bibliography, annotated bibliography, research papers, academic writings and business reports. Writers are required to be available on email or gtalk. Bidders should be good in written English (Native) and produce work that are 100% free from grammatical and spelling mistakes. Written work must be original - we will use software to check your work. Bidders should have good knowledge on referencing - APA/MLA/Harvard. Payment would be made via Paypal twice a month. Pay varies $8-$12 per 500 words While bidding kindly specify your area of expertise.
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I'm a meat-and-potatoes moviegoer more than I am a nuts-and-bolts one. Admittedly, considering my weird hardware-and-hearty-fare metaphoric and personal terminology, that no doubt means nothing to you. Here's what it means to me, and here's how I can best explain it:
I usually stay for the end credits, but not because I'm a cinema snob-o-rama who absolutely needs to take note of all the production details to find out who the 2nd Assistant Gaffer was. What I am most curious about – and this information is pretty much stuck on at the tail end of the credits -is the location settings and the music used; I'm resourcefully cheap enough to vicariously use films as travelogues and song sampling buyer's guides. And as long as I've waited the thirteen minutes to get to that point in the eye-glazing acknowledgments, I'll stick around to see if any animals were harmed in the making of the movie.
Another essential cinematic nutrient lies in keep-it-simple offerings. There's nothing terribly wrong with fast-food for thought, and I'm too impatient and restless for most multi-course feasts. Ninety minutes is a perfect length for a movie – a constraint conducive, like a short story, to disciplined craftsmanship.
But the most important ingredient for the best meat-and-potatoes fare lies in the good writing, of course; pearls of wit and wisdom that are contained in the bon mots and repartee make for a more memorable and evocative film, resonating long after the sticky floors, popcorn smells and nine bucks shelled out fade to black and blocked memory.
I may not always be able to tell you who-done-it, but I can usually remember who said it and what was said – committing quotes to recollection much better than problematic plots, cardboard characters, and the name of that 2nd Assistant Gaffer. Here's some of my favorite lines – some the usual suspects, others not AFI-approved – that satiates an aphoristic appetite and satisfies a hunger for gift-of-gab confabs, from stuff 'n' nonsense to a deeper truth-delving. The quotes are grouped into three classifications – other than that, no particular order. I don't need no stinkin' order:
1. The Appetizers. Usually non-essential to the plot, these do little to advance the story line but whets a desire for a film's full flavoring. Many are stand-alone lines or non-sequiturs that are funny, astute or absurd in and of themselves, regardless of who is saying them, although most are hinged upon an appropriate delivery and a few are almost inseparable from the character or actor:
"It's in that place where I put that thing that time." – Nancy Ticotin, Hackers.
"Gentlemen, you can't fight in here. This is the War Room!" – Peter Sellers, Dr. Strangelove.
"She tried to sit on my lap, and I was standing up at the time." – Humphrey Bogart, The Big Sleep.
"If I hold you any closer, I'll be in back of you." – Groucho Marx to Esther Muir, A Day at the Races.
"I'd like to kiss you, but I just washed my hair." – Bette Davis, The Cabin in the Cotton.
"Let's go get sushi and not pay!" – Dick Rude, Repo Man.
"He's the only man I know who can strut sitting down." – Gene Kelly on Fredric March's Mathew Harrison Brady, Inherit the Wind.
"Son, you got a panty on your head." – store clerk, Raising Arizona.
"We're not talking about killing people. Herb's talking about killing me and I'm talking about killing him." – Henry Travers, Shadow of a Doubt.
"What in the wide, wide world of sports is a-going on here?" – Slim Pickens, Blazing Saddles.
2. The Main Course. Dig in with these more substantial and cerebrally ample, satisfyingly, stick-to-your-ribs lines. These are usually integral to the plot and theme and overall tenor and mood of the movie, whether nourish or comedic. Not only character-driven but often used to define and convey character and personality, these are the quotes most ingrained with the protagonist or antagonist or actor–imbuing empathy or ill will–and sometimes helping, unfortunately, to typecast him or her:
"I don't mind if you don't like my manners. I don't like them myself. They're pretty bad. I grieve over them long winter evenings." – Humphrey Bogart, The Big Sleep.
"What a dump." – Bette Davis, Beyond the Forest.
"I can never get a zipper to close. Maybe that stands for something, what do you think?" – Rita Hayworth, Gilda.
"Who are those guys?" – Paul Newman and Robert Redford, at different times, Butch Cassidy and the Sundance Kid.
"She gave me a smile I could feel in my hip pocket." – Robert Mitchum, Farewell, My Lovely.
"There's no crying in baseball!" – Tom Hanks, A League of Their Own.
"It was a hot afternoon, and I can still remember the smell of honeysuckle all along that street. How could I have known that murder can sometimes smell like honeysuckle?" – Fred MacMurray, Double Indemnity.
"Would you mind putting that gun away? My wife doesn't mind but I'm very timid." – William Powell, The Thin Man.
"My, my. Such a lot of guns around here and so few brains." – Humphrey Bogart, The Maltese Falcon.
"It's a terrible thing to hate your mother. But I didn't always hate her. When I was a child, I only kind of disliked her." – Laurence Harvey, The Manchurian Candidate.
"I can no longer sit back and allow communist infiltration, communist indoctrination, communist subversion, and the international communist conspiracy to sap and impurify all of our precious bodily fluids." – Sterling Hayden, Dr. Strangelove.
"I don't use a pen. I write with a goose quill dipped in venom." – Clifton Webb, Laura.
"Goodness had nothing to do with it" – Mae West, after an onlooker said, "Goodness, what beautiful diamonds!" Night After Night.
"He used to be a tough mug, but he's cracked up and gone soft over a dame." – dock worker talking about Robert Armstrong, King Kong.
3. Dessert. Loosen-your-belt time. For good measure, these are the take-it-or-leave-it lines, not especially character-based, that put the icing on the cake for a little added surround-sound dimension. But they are often the ones – not especially imperative or inextricable from the fabric of the film – that you remember or try to look up later because you can take them out of context with no-harm no-foul consequences later on and repeat them as your own splendid witticisms. Or at least until the movie goes into wide-release:
"Positive thinking is fine in theory. But whenever I try it on a systematic basis, I end up really depressed." – Taylor Nichols, Barcelona.
"Sell crazy someplace else, we're all stocked up here." – Jack Nicholson,
As Good As It Gets.
"Playing strip poker with an exhibitionist somehow takes the challenge out of it." – Chris Eigeman, Metropolitan.
"I don't want to move to a city where the only cultural advantage is that you can turn right on a red light." – Woody Allen, Annie Hall
I see disaster; I see catastrophe; worse – I see lawyers!" – Danielle Ferland, Mighty Aphrodite.
"You chased a dog and you beat a horse. You're stronger than you think." – George Kellerman, The Out of Towners.
"I once asked this literary agent what writing paid the best, and he said `ransom notes.' " – Gene Hackman, Get Shorty.
And roll the credits . . .


text:
More than 75% of U.S. homes now have HDTVs, a 14% increase over 2011, and 40% have more than one HD set, Nielsen reported. Despite 61% of prime-time viewing taking place on an HD set in May, only 25% of cable prime time and 29% of English-language broadcast prime time happened in "true HD" -- meaning an HD set is hooked up to an HD signal and HD channels are being watched.
Full Story:Broadcasting & Cable, MediaPost Communications


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New Book on "Junk DNA" Surveys the Functions of Non-Coding DNA
What Discovery Institute biologist Jonathan Wells calls the "myth of junk DNA," long a favorite with advocates of unguided evolution, isn't yet quite dead and buried. You still see it invoked in popular science media. Last month in The New York Times Magazine, Carl Zimmer defended the notion that our genome is mostly garbage, earning cheers from evolutionary advocates like PZ Myers and Lawrence Moran, the latter hailing Zimmer as the "best science journalist on the planet." We devoted some attention to Zimmer's article (see here and here). But for many scientists, "junk DNA" is an idea that is increasingly untenable in light of the empirical data.
A new book from Columbia University Press, Junk DNA: A Journey Through the Dark Matter of the Genome, by virologist Nessa Carey provides a detailed review of the vast evidence being uncovered showing function for "junk DNA." She explains that junk DNA was initially "dismissed" by biologists because it was thought that if it didn't code for proteins, it didn't do anything:
For years, scientists had no explanation for why so much of our DNA doesn't code for proteins. These non-coding parts were dismissed with the term "junk DNA." But gradually this position has begun to look less tenable, for a whole host of reasons. (p. 2)Of course in dismissing non-coding "junk" DNA, we must conclude that these same evolutionary scientists hindered research into its function.
Now Carey gives no indication that she's an ID proponent and in fact she adopts many standard evolutionary viewpoints within her book. But note how, in making her case that we ought to suspect non-coding DNA has function, she employs a curious analogy. She draws a comparison to a car factory -- something that obviously is intelligently designed:
Perhaps the most fundamental reason for the shift in emphasis is the sheer volume of junk DNA that our cells contain. One of the biggest shocks when the human genome sequence was completed in 2001 was the discovery that over 98 per cent of the DNA in a human is junk. It doesn't code for any proteins. ...Don't miss that last line: "The whole organization only works when all the components are in place. And so it is with our genomes." Doesn't that sound exactly like irreducible complexity? So here we have a biologist, unaffiliated with the intelligent-design community, arguing that junk DNA must be functional because it's like a car factory where all the components are needed in order for the entire system to function. Critics might claim that ID has had no impact on biological thinking, but the evidence shows otherwise.
...Let's imagine we visit a car factory, perhaps for something high-end like a Ferrari. We would be pretty surprised if for every two people who were building a shiny red sports car, there were another 98 who were sitting around doing nothing. This would be ridiculous, so why would it be reasonable in our genomes? ...
...A much more likely scenario in our car factory would be that for every two people assembling a car, there are 98 others, doing all the things that keeps a business moving. Raising finances, keeping accounts, publicizing the product, processing the pensions, cleaning the toilets, selling the cars etc. This is probably a much better model for the role of junk in our genome. We can think of proteins as the final end points required for life, but they will never be properly produced and coordinated without the junk. Two people can build a car, but they can't maintain a company selling it, and certainly can't turn it into a powerful and financially successful brand. Similarly, there's no point having 98 people mopping the floors and staffing the showrooms if there's nothing to sell. The whole organization only works when all the components are in place. And so it is with our genomes. (p. 3)
Before moving on I must make a point about terminology. At the beginning of the book, Carey notes that when she uses the term "junk DNA," she does so to describe any stretch of non-coding DNA, and doesn't necessarily mean something that has no function. "Anything that doesn't code for a protein will be described as junk, as it originally was in the old days (second half of the twentieth century)," she writes. Thus, she's not affirmatively claiming the piece of "junk DNA" doesn't have function. Rather, she's referring to a type of DNA that was once thought to be functionless "junk," and now is most likely thought to have function.
Carey, in any event, goes on to explain how today we now believe that, far from being irrelevant, it's the "junk DNA" that is running the whole show:
The other shock from the sequencing of the human genome was the realisation that the extraordinary complexities of human anatomy, physiology, intelligence and behaviour cannot be explained by referring to the classical model of genes. In terms of numbers of genes that code for proteins, humans contain pretty much the same quantity (around 20,000) as simple microscopic worms. Even more remarkably, most of the genes in the worms have directly equivalent genes in humans.Of course by "evolutionary complexity," what Carey means is genomic functionality. She goes on to spend the bulk of the book reviewing the numerous discoveries of function for non-coding "junk" DNA. Just a few of those include:
As researchers deepened their analyses of what differentiates humans from other organisms at the DNA level, it became apparent that genes could not provide the explanation. In fact, only one genetic factor generally scaled with complexity. The only genomic features that increased in number as animals became more complicated were the regions of junk DNA. The more sophisticated an organism, the higher the percentage of junk DNA it contains. Only now are scientists really exploring the controversial idea that junk DNA may hold the key to evolutionary complexity. (p. 4)
- Structural roles such as packaging chromosomes and preventing DNA "from unravelling and becoming damaged," acting as "anchor points when chromosomes are shared equally between different daughter cells and during cell division," and serving as "insulation regions, restricting gene expression to specific regions of chromosomes."
- Regulating gene expression, as "Thousands and thousands of regions of junk DNA are suspected to regulate networks of gene expression."
- Introns are extremely important:
The bits of gobbledygook between the parts of a gene that code for amino acids were originally considered to be nothing but nonsense or rubbish. They were referred to as junk or garbage DNA, and pretty much dismissed as irrelevant. ... But we now know that they can have a very big impact. (pp. 17-18)
- Preventing mutations by separating out gene-coding DNA.
- Controlling telomere length that can serve as a "molecular clock" that helps control aging.
- Forming the loci for centromeres.
- Activating X chromosomes in females.
- Producing long non-coding RNAs which regulate Hox genes or regulating brain development, or serving as attachment points for histone-modifying enzymes helping to turn genes on and off.
- Serving as promoters or enhancers for genes, or imprinting control elements for "the expression of the protein-coding genes."
- Producing RNA which acts "as a kind of scaffold, directing the activity of proteins to particular regions of the genome."
- Producing RNAs which can fold into three-dimensional shapes and perform functions inside cells, much like enzymes, changing the shapes of other molecules, or helping to build ribosomes. As she notes: "We've actually known about these peculiar RNA molecules for decades, making it yet more surprising that we have maintained such a protein-centric vision of our genomic landscape." (p. 146)
- Serving as tRNA genes which produce tRNA molecules. These genes can also serve as insulators or spacers to stop transcription from spreading from gene to gene.
- Development of the fingers and face; changing eye, skin, and hair color; affecting obesity.
- Gene splicing and generating spliceosomes.
- Producing small RNAs which also affect gene expression.
Carey rightly calls the ENCODE project (Encyclopedia of DNA Elements) an "evolutionary battleground." That's because it claimed that some 80 percent of our genome is functional, a finding that some evolutionary biologists have vigorously disputed. Of course ENCODE's findings are based upon empirical data, and evolutionary objections are based upon theoretical concerns. That's why evolutionary biologists find ENCODE so threatening to their models. Though Carey doesn't mention this, Dan Graur said, "If ENCODE is right, then evolution is wrong." What's going on here?
The main evolutionary response, as Carey explains, is that "only about 5 percent of the human genome is conserved across the mammalian class." Since evolutionary biologists assume that a structure is only functional if it's under selection, non-conserved sequences suggest a sequence is not under selection pressure. Hence, they assume all that DNA can't be functional.
Carey provides a very good response to this argument, which I'll get to in a moment. But from an ID perspective there's an immediate rebuttal that is obvious: If we abandon the assumption that natural selection alone can generate functional elements in our genome, then we're freed up to consider that perhaps many functional elements of mammalian genomes did not arise by selection but were designed separately with distinct DNA sequences from the very beginning. That would result in the exact sort of data that ENCODE is revealing -- vast quantities of non-conserved functional genetic elements -- that is vexing evolutionary biologists. Indeed, other previous studies have revealed non-conserved DNA that has specific functions. As Jonathan Wells explains:
But while sequence conservation may imply function, non-conservation does not imply non-function -- as biologists have long recognized. Indeed, to whatever extent DNA differences play a role in distinguishing different species, non-conserved sequences must be functional.Carey provides another intriguing hypothesis -- that even from an evolutionary perspective many functional genetic elements may be under relaxed selection for DNA sequence. She writes:
Furthermore, biologists now know that as much as 30 percent of the protein-coding DNA in every organism consists of "orphan genes" that bear little or no similarity to DNA sequences in other organisms. While the functions of most orphan proteins are not yet known, few people would be so foolhardy as to suggest that they are non-functional. Yet in a search for evolutionary constraint such as the Oxford researchers used, these protein-coding regions would be judged non-functional.
Protein-coding sequences are highly conserved in evolution because a particular protein is often used in more than one tissue or cell type. If the protein changed in sequence, the altered protein might function better in a particular tissue. But that same change might have a really damaging effect in another tissue that relies on the same protein. This acts as an evolutionary pressure that maintains protein sequence.Her argument makes sense: genetic elements that interact with fewer aspects of an organism's genome, transcriptome, proteome, and other physiological components, might face fewer sequence-constraints than those that maybe have only one such interaction. Evolutionary biologists tend to assume that selection works the same in all physiological contexts, but if that's not true, then we could see relaxed selection allowing genetic elements to be functional and non-conserved.
But regulatory RNAs, which don't code for proteins, tend to be more tissue-specific. Therefore they are under less evolutionary pressure because only one tissue relies on a regulatory RNA, and possibly only during certain periods of life or in response to certain environmental changes. This has removed the evolutionary brakes on the regulatory RNAs and allowed us to diverge from our mammalian cousins in these regions. (p. 195)
Carey notes that ENCODE critics, namely evolutionary biologists, reacted harshly to ENCODE's claims that the vast majority of our genome is functional (pp. 196-197):
The most forthright responses were mainly from evolutionary biologists. This wasn't altogether surprising. Evolution is the biological discipline where emotions tend to run highest. Normally the bullets are targeted at creationists, but the Gatling guns may also be turned on other scientists. ... The angriest critique of ENCODE included the expressions "logical fallacy," "absurd conclusion," "playing fast and loose" and "used the wrong definition wrongly." Just in case we were still in doubt about their direction of travel, the authors concluded the paper with the following damning blast:She notes: "There are interesting scientific arguments on both sides, but it would be disingenuous to believe that the amount of heat and emotion generated by ENCODE has been purely about the science. We can't ignore other, very human factors." (p. 198)The ENCODE results were predicted by one of its lead authors to necessitate the rewriting of textbooks. We agree, many textbooks dealing with marketing, mass media hype, and public relationships may well have to be rewritten.
In any case, I suspect that Carey herself holds an even more pro-ENCODE view than her book lets on, and what we see may be a toned-down version of what she really thinks. She seems to be diplomatically trying to avoid the "emotional" attacks of angry evolutionary biologists who stridently oppose ENCODE.
Much Research Remains to Be Completed
Carey doesn't openly take a side in the debate over ENCODE, and she doesn't claim that our genome will eventually turn out to contain no "junk" DNA whatsoever. But she is clear that the trend line in research is away from junk DNA, and she notes that one reason for our lack of understanding of what a lot of junk DNA does is that we haven't yet developed the technologies to study it:
Part of the problem is that the systems we can use to probe the functions of junk DNA are still relatively underdeveloped. This can sometimes make it hard for researchers to use experimental approaches to test their hypotheses. We have only been working on this for a relatively short space of time. (p. 6)In other words, it's very premature to conclude that our genome is full of truly functionless junk DNA. Lacking the technology to detect function, it's understandable why we might have missed a lot of the important functions going on in the genome.
As Carey notes, "We now know that in some cases just a single base-pair change in an apparently irrelevant region of the genome can have a definite effect" (p. 201), meaning there's a lot of work left to be done. After all, she points out: "One stretch of DNA can include a protein-coding gene, long non-coding RNAs, small RNAs, antisense RNAs, splice signal sites, untranslated regions, promoters and enhancers." (p. 287) Thus, she concludes, "When we really think about the complexity of our genomes, it isn't surprising that we can't understand everything yet." (p. 288) And that, along with much else in this excellent book, hits the nail on the head.


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Leicester City Filbert Fox Womens Hoodie
Support the Foxes with this Leicester City F C Mascot – Filbert Fox! We print all Hoodies using the latest DTG print technology and highest quality inks to ensure a superior print quality and a lasting finish. The double fabric hood with self-coloured drawcord and a front kangaroo pouch pocket makes this Hoodie just perfect.
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Crafted from an extra life lycra blend for extended wear, these fold over detail bikini briefs from Freya boast a paint brush graffiti print throughout. Team with the coordinating bikini top to complete your look.
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Lay out only the copy for the front of our software box . 7 1/2 x 5 1/4. we supply copy.
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Lay out only the copy for the front of our software package (box). We supply copy. In-House version for [url removed, login to view] also be supplied. New company with present tight budget of $75 to $100.Get free quotes for a project like this
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Pedros Tutto Multi Chain Tool
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Highlighted Features
- Actual weight 361 grams
- Steel construction
- Compatible with single-speed chains all the way to eleven-speed chains, including Campy
- Fit Dial
- Retracting Pin Guide
- Peening bit for Campagnolo 11-speed chains
- Guide pin shear slot
- Manufactured in Taiwan
Remember when 8-speed drivetrains were the cutting edge of technology? Oh, you still have your 8-speed chain tool? And your nine-speed, and your ten-speed, and now you're looking to get an eleven-speed compatible tool as well for your next upgrade? Look no further than Pedro's Tutto Multi Chain Tool, able to snap together all 1/8" and 3/32" bicycle chains, from single to eleven speed.
Multiple chain style compatibility is enabled by the rotating Fit Dial, which spins to present an anvil to accept either 1-8, 9/10, 11-speed, and a peening surface for Campagnolo 11-speed chains. Threaded into the Tutto's handle is a peening bit, which fits into the proprietary Retracting Pin Guide, or RPG. The RPG securely holds chain-connecting pins to ensure proper alignment. Once a chain connecting pin is installed, insert the guide portion of the pin into the Tutto's guide pin shear slot to cleanly snap it off.
Constructed from cast metal, the Tutto is built to last a lifetime. Completely serviceable, and with ergonomic handles, the Tutto will encourage you to finally swap chains at proper intervals.
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Wondershare Dr.Fone(iphone4), Download Version Item # 465842
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Wondershare Dr.fone is the World's 1st iPhone, iPad and iPod touch data recovery software for personal users. It can recover deleted data directly from iPhone 4 and also regain previous data from iTunes backup. It saves data and retrieves lost data.
Wondershare Dr.fone can get back your lost Contacts, Photos, Messages and more from two modes:
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- Text content: such as Contacts, Messages, Call History, Calendar, Notes, Reminders and Safari Bookmark
This iPhone data recovery software allows you to:
- Preview lost files before recovery, in a clear and organized manner with files in their original quality
- Review contacts in detail, including address, job title, etc.
- Read SMS contents including iMessages, photos, videos, etc.
- Export and check your list of lost files in HTML.
Product Details
|Item #
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|Wondershare Software Co., Ltd
|Arvato digital services Canada, Inc.
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|256 MB or more of RAM (1028MB Recommended)
|minimum hard disk space
|200 MB and above free space
|minimum processor compatibility
|1GHz (32 bit or 64 bit)
|operating system compatibility
|Windows 7 Starter; Windows 7 Home Basic; Windows 7 Home Premium; Windows 7 Professional; Windows 7 Ultimate; Windows 7 Enterprise; Windows 7 Home Basic x64; Windows 7 Home Premium x64; Windows 7 Professional x64; Windows 7 Ultimate x64; Windows 7 Enterprise x64
|Wondershare Software Co., Ltd
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