text:
More Videos...
Dubai desert Fun - 2nd Dec 2011 - Area 53 - Morning Drive - Emarat 4x4
Dubai desert Fun - 2nd Dec 2011 - Area 53 - Morning Drive - Emarat 4x4 Captured by : AllTerrain
4x4 Dubai Desert Safari
Shot in May whilst on Holidays in Dubai. Camera was a Sony Z1 HDV camera shot in 1080i.
almost4x4 Off-Road Club. Jeeping in Dubai Desert HD
11 Mar 2008 Abu Dhabi - Dubai Highway Part 1
On the 11th of March 2008, I was with my friend Assim. We were chilling at a coffee shop called Dar El Hai in Abu Dhabi Khalidiah. It was 03:00 am when I asked him to join me for a trip to Dubai after the sun rise to finish some work there. I told him " The earlier we hit the road, the fastest we reach Dubai" . He suggested that we leave at 06:00 am because 5 am is too early. When it was six we took the road on our misterious trip. "What if we got into an accident?" Assim said, I was not happy with his comment so I said: "What If you say something better than what're you saying now". We got off the Um Al Nar bridge and by the time we're getting close to Al Shahama City, the fog was blinding everyone. I couldn't see but 30 to 40 m ahead of me. I was driving by a 80 km/h with my windows roled down. I saw some headers flashing me from the back, I wondered " What's wrong with that Jaguar owner? " he passed me with him waving me with a sign that I didn't get at the begining. So I looked at my dash board and noticed that my car lights are on auto switch and it didn't turn on, so I turned it on and also my fog lights too. Five minutes after that I saw ghousts waving at me, I slowed down fast hearing an egyption accient asking me to get off the road. I knew then that there's a pile a head of me. Quick, I took the side of the road and stoped totally. Shouted at Assim to jump out of the car and followed him from the passenger door. I then heard the anger of the mital, the sound of the breaks and the smashing of the cars one by one. after 5 minutes that seemed like 5 hours, everything went hush. With the pile of the cars and its heat the fog was cleared, and what I saw made me hlod my NOKIA E90 and film my 17 minutes video that I've part it into 9 parts to share it with all of you. This video was brodcasted on Abu Dhabi Television in Oloum El Dar News Show and upon it we had the exclusive interview with His Highness Shaikh Saif Bin Zayed in our studios to talk about that morning, The Tuesday Fog.


text: OverviewBack to top Hugo Naturals - Effervescent Bath Salts Energizing Grapefruit & Geranium - 14 oz. Item# :124716UPC# :879779004348 Brand:Hugo Naturals Size/Form:14 oz. Ship Weight:0.90 Hugo Naturals - Effervescent Bath Salts Energizing Grapefruit & Geranium - 14 oz. Hugo Naturals Effervescent Bath Salts Energizing Grapefruit & Geranium is a mineral-rich blend of genuine Dead Sea salts and rare Himalayan Pink salts, used for centuries to soothe, detoxify and reduce muscle tension. Organic golden jojoba oil and sweet almond oil moisturize, soften and replenish essential nutrients to dry, dull skin. Rich and fresh Mango & Guava essence creates a deeply relaxing and luxurious spa experience. Drop a handful or more into warm bath water, and watch as hundreds of effervescent bubbles, full of nourishing minerals and pure essential oils are released. Frequently Asked Questions What does Hugo Naturals Cruelty-free certification mean?Hugo Naturals is certified cruelty-free by the Leaping Bunny which is a program run by the Coalition for Consumer Information on Cosmetics (CCIC). Products bearing the Leaping Bunny symbol are certified "cruelty-free" under the internationally recognized Humane Cosmetics or Humane Household Products Standards. These rigorous standards stipulate that no animal testing is conducted or commissioned for finished products or ingredients in any phase of product development by the company, its laboratories or its suppliers after a fixed cut-off date. As a result, Hugo Naturals cruelty-free certification means that they, as a company are bound to never test the final products on animals, nor use ingredients that have been tested on animals. They require all their suppliers to certify that the ingredients/raw materials they provide to them have not been tested on animals and they have a very strict policy with regards to that. Hugo Naturals also does not sell their products in China or other countries that require imported personal care products be tested on animals. They refuse to sell to those markets until their laws on animal testing change. They are happy and proud to stand by their position, as their belief in cruelty-free products (and a cruelty-free world) is one of their core values. Which of the Hugo Naturals products are gluten-free? Soy-free?The only products that contain oats in their entire line are the Shea Butter & Oatmeal Bar Soap and the Oatmeal Mint Artisan-Bulk Soap. Both of these products have whole oats on the top surface that have been tested and certified gluten free. If your allergies are with wheat, the oats have not been cross contaminated. If you choose to incorporate oats, their soaps would be a good choice. The rest of Hugo Naturals entire product line is soy, oat and gluten-free, as well as vegan. As a matter of fact, they are certified by the Celiac Sprue Association, or CSA, which is the largest celiac support organization in the United States. How does Hugo Naturals prevent their products from spoiling? Do they use preservatives?One strategy Hugo Naturals employs is reducing the amount of water contained in their products. The water content of a product is a major factor in spoilage. Due to the low water content they are able to use all-natural preservatives such as Japanese Honeysuckle extract and rosemary extract. Many of their other ingredients have preservative properties as well. Essentially, they give you more for your money and in the process eliminate the need to use chemical preservatives. How does Hugo Naturals scent their products?The natural way! They use only 100% natural essential oils and botanical extracts. They do not use water or alcohols in their extracts, but instead use kosher vegetable glycerin as a base. Does Hugo Naturals only use natural colors?Yes. They quite literally searched the world looking for natural ingredients with colorful properties. They have discovered that they can use natural colorings from seeds, pulp, algae, chlorophyll, and other completely natural ingredients to produce vibrant colors without the potentially harmful side-effects of artificial ingredients. About Hugo Naturals Products Hugo Naturals is a natural personal body care line that is both exceptionally pure and deliciously pampering. They hand-select only the finest, natural, food-grade ingredients available, and blend them according to their original recipes to create the ultimate in pure products for skin, hair, baby and home. Though the company has grown in size from the days they began selling handcrafted soaps at their local Farmer's Market, their commitment to making every product with the same care and quality remains. Every Hugo Naturals product is handcrafted in the USA from only the finest natural, food-grade ingredients available. Their products are free of petrochemicals, animal fats, parabens, silicones, formaldehyde, hydroquinone, phthalates, propylene glycol, and synthetic surfactants. Hugo Naturals products are never tested on animals, are gluten free and made from sustainable sources that are pure and natural. The raw materials they use to manufacture the products are the most pure and natural available. Many of the ingredients they use are not used by any other body care company in the industry. Their efficacious ingredients are grown in rich, naturally nurturing soils following the law of nature without the use of toxic or persistent chemical pesticides or herbicides. Hugo Naturals work with famers who emphasize the use of renewable resources and harvest their crop according to specified methods. Their lotions, scrubs and creams are exquisitely scented with pure essential oils and plant essences that delight the senses, deeply moisturize, and add protection from the environment while feeling as rich and indulgent as spa treatments. Being respectful of the earth's natural resources, and being a steward of this wonderful planet is what Hugo Naturals is all about. They are known for their tireless commitment to quality, purity and 100% customer satisfaction.

subset: commoncrawl


text:
Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion: a prospective cohort study
- Tobias M Bingold1Email author,
- Barbara Pullmann1,
- Sven Sartorius1,
- Emanuel V Geiger2,
- Ingo Marzi2,
- Kai Zacharowski1,
- Heimo Wissing†3 and
- Bertram Scheller†1
DOI: 10.1186/cc10141
© Bingold et al.; licensee BioMed Central Ltd. 2011
Received: 7 February 2011
Accepted: 15 April 2011
Published: 15 April 2011
The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following traumatic lung contusion.
In a study population of 45 adult patients with multiple trauma and lung contusion, we obtained bronchoalveolar lavage (BAL) (blind suctioning of 20 ml NaCl (0.9%) via jet catheter) and collected blood samples at two time points (16 hours and 40 hours) after trauma. Post hoc patients were assigned to one of four groups radiologically classified according to the severity of lung contusion based on the initial chest tomography. Concentration of soluble TREM-1 (sTREM-1) and bacterial growth were determined in the BAL. sTREM-1, IL-6, IL-10, lipopolysaccharide binding protein, procalcitonin, C-reactive protein and leukocyte count were assessed in blood samples. Pulmonary function was evaluated by the paO2/FiO2 ratio.
Three patients were excluded due to positive bacterial growth in the initial BAL. In 42 patients the severity of lung contusion correlated with the levels of sTREM-1 16 hours and 40 hours after trauma. sTREM-1 levels were significantly (P < 0.01) elevated in patients with severe contusion (2,184 pg/ml (620 to 4,000 pg/ml)) in comparison with patients with mild (339 pg/ml (135 to 731 pg/ml)) or no (217 pg/ml (97 to 701 pg/ml)) contusion 40 hours following trauma. At both time points the paO2/FiO2 ratio correlated negatively with sTREM-1 levels (Spearman correlation coefficient = -0.446, P < 0.01).
sTREM-1 levels are elevated in the BAL of patients following pulmonary contusion. Furthermore, the levels of sTREM-1 in the BAL correlate well with both the severity of radiological pulmonary tissue damage and functional impairment of gas exchange (paO2/FiO2 ratio).
Triggering receptor expressed on myeloid cells-1 (TREM-1) belongs to the immunoglobulin superfamily and is expressed on the surface of myeloid cells (for example, neutrophils). The receptor mediates the inflammatory response to infectious microorganisms by pathogen-associated molecular patterns [1] and might be activated in Toll-like receptor (TLR)-dependent or TLR-independent fashion [2]. A recent meta-analysis of 73 studies confirmed that the soluble form of this receptor (sTREM-1) is a reliable biomarker for bacterial infections [3].
The study by Porfyridis and colleagues showed that the expression of TREM-1 on neutrophils and on monocytes and of sTREM-1 in serum are reliable diagnostic markers of community-acquired pneumonia [4], whilst other studies showed that sTREM-1 in serum is also increased in ventilator-associated pneumonia and sepsis [5, 6].
The presence of sTREM-1 in bronchoalveolar fluid of mechanically ventilated patients is a strong predictor for the presence of pneumonia with a cut-off value of 230 pg/ml to predict acute inflammatory changes in response to bacterial infestation [7, 8].
Abacterial inflammation is observed in almost 30% of patients with multiple trauma associated with pulmonary contusion [9]. Pulmonary contusion results in disruption of the epithelial and endothelial cell lining of the lung, impairment of the alveolar-capillary barrier, an activation of the innate inflammatory response and subsequent recruitment of leukocytes, monocytes and tissue macrophages [9]. The resulting self-propagating inflammation within the alveolar space might cause devastating lung injury and is associated with a significant mortality.
Given the role of sTREM-1 as a biological marker for an inflammatory response within the lung, we pursued the hypothesis that the inflammation induced by severe trauma might lead to the expression of sTREM-1 within pulmonary tissue. In addition, we correlated the levels of sTREM-1 to the clinical course of pulmonary function and the severity of lung contusion as assessed by a scoring system based on initial CT scans.
Materials and methods
We included patients admitted to our ICU between 2007 and 2009 suffering from multiple trauma. According to a standardised emergency room protocol, a multislice CT scan was performed in all trauma patients on admission to the hospital. Patients were screened for study enrolment on admission to the ICU. We included patients >18 years of age with multiple trauma and an indication for kinetic therapy (Rotorest®; KCI GmbH, Wiesbaden, Germany), with visible lung contusion in the initial CT scan and/or Abbreviated Injury Scale thorax >3. Informed consent was obtained from their next of kin. Patients were excluded if no informed consent could be obtained or patient bodyweight exceeded 120 kg. Three patients with a positive result for intracellular organisms or a quantitative culture ≥104 colony-forming units per millilitre in any bronchoalveolar lavage (BAL) collected were therefore excluded from the study population.
Clinical data were documented according to the German Trauma Registry Data Set, which allows quality control and outcome parameters [10]. In addition, every patient was scored for severity of trauma using the Abbreviated Injury Scale (2008 update; Association for Advancement of Automatic Medicine, Barrington, IL, USA) and the Injury Severity Score [11].
In total, 42 patients participated in this prospective cohort study. The study was approved by the local ethics committee (Ethik-Kommission, Johann Wolfgang Goethe-Universität Frankfurt am Main).
Clinical treatment and data sampling
Following initial trauma care and surgical intervention, patients were mechanically ventilated (Evita4/XL; Draeger, Lübeck, Germany) and subjected to kinetic therapy using a Rotorest® bed (KCI GmbH) for a minimum of 48 hours. Weaning protocols were designed to keep a positive end-expiratory pressure level of 15 mbar with the aim of weaning the patients to spontaneous ventilation within the initial 24 hours. Weaning to spontaneous ventilation mode was realised by successively minimising ventilator support from assisted spontaneous breathing to pressure support of 0 to 15 mbar or to proportional pressure support of 0 to 4 ml/mbar//mbar/l*sec.
All patients received antibiotic treatment at admission to the emergency room (cefuroxime 1.5 g). In the ICU 39 out of 42 patients received further anti-infective treatment due to open fractures, severe skin lesions (penicillin or cefuroxime) or open brain trauma (meropeneme).
BAL samples were collected 16 hours and 40 hours following trauma. An AeroJet catheter (Covidien GmbH, Neustadt, Bayern, Deutschland), containing two lumina, was inserted via the endotracheal tube under sterile conditions. Then 20 ml NaCl (0.9%) were administered into the lung via the flushing line followed by suction to obtain a fluid sample. The BAL samples were divided into two parts: one portion was analysed microscopically and cultured for microbiological analysis; the second portion was centrifuged (Eppendorf Centrifuge 5702R; Eppendorf AG, Hamburg, Germany) for 15 minutes at 4°C and the resulting supernatant stored at -80°C. Positive BAL was defined either as the presence of cells containing intracellular organisms or a quantitative culture ≥104 colony-forming units per millilitre of BAL. Levels of sTREM-1 in BAL supernatant were determined by ELISA (Human TREM-1 Quantikine ELISA Kit, version DTRM10B; R&D Systems, Minneapolis, MN, USA).
Vital signs as well as the potential occurrence of pneumonia, systemic inflammatory response syndrome or sepsis were documented daily. Routine blood samples were taken once a day via the arterial line and were centrifuged immediately, with the resulting serum aliquots stored at -80°C. IL-6, IL-10 and lipopolysaccharide binding protein (LBP) were determined in the serum using Immulite 2000 (Siemens Medical Solutions Diagnostics GmbH, Bad Nauheim, Germany).
sTREM-1 in serum was analysed in the same way as the BAL, with ELISA (Human TREM-1 Quantikine ELISA Kit, version DTRM10B; R&D Systems).
Patients were classified post hoc according to the severity of lung contusion based on the initial CT scan by two independent physicians. Classification was set by visual quantification of the amount of lung contusion (area of high density of lung tissue), ventral and dorsal damage, and one or both sides affected. Four classes of severity of lung contusion resulted: no lung contusion - no signs of lung tissue damage in the initial CT scan; mild lung contusion - moderate ventral or dorsal damage of lung tissue on one side of the lung; moderate lung contusion - moderate ventral and dorsal damage of lung tissue, or dorsal or ventral severe damage on one side of the lung; and severe lung contusion - multiple contusions on one or both sides of the lung.
Statistical analysis
Statistical analysis was performed using Sigma Plot 11.0 (Systat Software, Inc., San Jose, CA, USA). All data were tested for normal distribution (Shapiro-Wilk test). Data with a negative test for normal distribution are presented as the median with the 25 to 75% range. Normally distributed values are presented as the mean ± standard deviation. A two-tailed P value < 0.05 was considered statistically significant.
A correlation between sTREM-1 and the paO2/FiO2 ratio or lung contusion score was assessed using Spearman's correlation test. Analysis of variance on ranks was performed for sTREM-1 in dependency on the severity of lung contusion and length of stay (LOS) in the ICU (Kruskal-Wallis test; pairwise multiple comparisons were corrected with Dunn's method). Paired multiple comparisons (IL-6/LBP) were corrected using the Bonferroni test (α = 0.05).
Demographics of the study population, scoring for severity of illness and clinical outcome
Lung contusion at initial CT scan
P value
Median age (years)
Gender (n)
Body mass index
Injury Severity Score (median)
APACHE II score (median)
SAPS II (median)
Length of stay (days)
Mortality (n)
sTREM-1 levels in BAL samples were compared with the radiological classified severity of lung contusion at two time points post traumatic injury (16 hours and 40 hours post trauma). Increasing severity of trauma correlated with mean values of sTREM-1 levels (P < 0.01, Spearman Rank order correlation (Rs) = 0.461 for 16 hours following trauma; and P < 0.001, Rs = 0.582 for 40 hours following trauma, respectively).
The paO2/FiO2 ratio at bedside is established to estimate the severity of oxygenation impairment following lung injury. We therefore correlated paO2/FiO2 with sTREM-1 in BAL. Patients were ventilated at this time point with positive end-expiratory pressure of 15 mbar. There was a negative correlation between sTREM-1 values and the paO2/FiO2 ratio (Rs = -0.446, P < 0.01 for 16 hours following trauma; and Rs = -0.425, P < 0.01 for 40 hours following trauma). sTREM-1 values in BAL were not correlated with disease severity (Injury Severity Score, Abbreviated Injury Scale, Acute Physiology and Chronic Health Evaluation II, Simplified Acute Physiology Score II) and LOS of patients in the ICU.
The LOS of patients in the ICU was significantly longer in patients with severe lung contusion (P < 0.05, Kruskal-Wallis test) (Table 1). Severity of lung contusion had no significant influence on LOS in the hospital. There was no correlation between LOS in the ICU and sTREM-1 values in BAL or the paO2/FiO2 ratio.
Additionally we measured sTREM-1 in serum. sTREM-1 values in serum are elevated both 16 hours and 40 hours following trauma, but showed no significant differences between groups of severity of lung contusion or severity of disease. Furthermore there was no correlation to LOS in the ICU or LOS in the hospital.
Data for patients with systemic inflammatory response syndrome and for patients without systemic inflammatory response syndrome also showed no significant difference during the first 40 hours. Within the first 40 hours none of the patients was diagnosed with sepsis or suspected to suffer from an infection of any kind.
Cytokine levels in blood serum (IL-6, IL-10, LBP, C-reactive protein, procalcitonin, leukocyte count) showed a typical kinetic profile after trauma and were elevated both at 16 hours and 40 hours after trauma.
Cytokine and sTREM-1 values in serum 16 hours and 40 hours following trauma
Lung contusion at initial CT scan
16 hours
40 hours
16 hours
40 hours
16 hours
40 hours
16 hours
40 hours
16 hours
40 hours
182 (112 to 363)
134* (70 to 282)
276 (185 to 443)
348 (120 to 600)
137 (66 to 223)
90 (54 to 163)
184 (108 to 225)
104 (66 to 209)
183 (132 to 418)
157* (64 to 290)
14 (6 to 40)
5* (5 to 11)
26 (12 to 41)
16 (7 to 47)
21 (13 to 49)
5* (4 to 11)
10 (6 to 42)
5 (5 to 11)
12 (5 to 36)
5* (4 to 6)
0.47 (0.11 to 1.11)
0.45 (0.14 to 2.15)
0.1 (0.09 to 0.55)
0.3 (0.15 to 1.23)
0.15 (0.08 to 1.06)
0.16 (0.11 to 1.54)
0.56 (0.17 to 0.68)
0.41 (0.10 to 0.63)
0.90 (0.36 to 6.01)
1.1 0.27 to 5.10)
2.4 (1.2 to 4.6)
10.4* (7.3 to 14.2)
1.2 (0.8 to 2.8)
8.0 (6.3 to 11.5)
2.0 (1.5 to 5.7)
8.4* (7.2 to 14.3)
2.4 (1.5 to 3.7)
10.9* (8.8 to 13.6)
3.9 (0.4 to 4.8)
12.1* (9.0 to 17.1)
7.6 (5.5 to 9.9)
8.0 (6.3 to 10.2)
6,5 (5.3 to 9.0)
6.3 (5.2 to 7.1)
8.0 (6.9 to 10.0)
8.2 (6.9 to 11.8)
7.4 (4.9 to 13.6)
6.4 (5.4 to 9.8)
7.7 (5.5 to 8.5)
9.2* (7.9 to 11.2)
13 (7 to 18)
24* (16 to 30)
8 (5 to 16)
22 (12 to 30)
12 (8 to 17)
16 (10 to 21)
13 (7 to 18)
26* (23 to 29)
15 (10 to 20)
26* (22 to 37)
sTREM-1 serum
149 (108 to 199)
145 (85 to 198)
94 (70 to 282)
90 (76 to 188)
121 (88 to 215)
146 (75 to 180)
145 (97 to 186)
137 (99 to 187)
157 (134 to 188)
204 (109 to 257)
To date, sTREM-1 has been shown to be expressed during pathogen-associated bacterial or fungal pneumonia [7, 8]. The role of sTREM-1 during non-infectious inflammation or trauma, however, is not well elucidated. We report here that sTREM-1 is expressed in the alveolar space during the course of non-infectious inflammation due to traumatic lung contusion. We could observe that the expression of sTREM-1 is increased until 40 hours following pulmonary contusion. The severity of lung contusion correlated well with the levels of sTREM-1 in the BAL and the functional impairment of pulmonary function following trauma.
The role of TREM-1 was initially described on neutrophils and monocytes [1]. The authors observe that TREM is activated through lipopolysaccharides present on the surface of bacteria, and that this activation enhances an inflammatory response in an ERK1/2-depenedent and phospholipase-C-dependent fashion. The role of sTREM-1 was then further elucidated during septic shock, identifying its activating role for cytokine release. This activation was associated with an increased serum concentration of sTREM-1 in response to bacterial sepsis. This soluble form was postulated to be increased due to transcriptional activation but the increase could also be due to cleavage from the cellular surface [12]. Furthermore, TREM-1 is known to modulate the innate response either by amplifying or dampening TLR-induced signalling [13]. The in vitro inhibition of TREM-1 results in reduced gene expression of the TLR4 pathway, such as the expression of CD14, myeloid differentiation protein-88, IL-10, IL-1β and monocyte chemotactic protein-1 [14]. This inhibition was also implied during bacterial infection in a murine model of pneumococcal pneumonia. The authors postulated that sTREM-1 could hold a protective function for the healing process of the lung [15]. TLR activation, however, is not only initiated by pathogen-associated molecular patterns but also by damage-associated molecular patterns that are released during lung contusion, such as during deceleration or blunt trauma of the lung.
To our knowledge no published data are currently available about the levels of sTREM-1 during non-infectious inflammation of the lung. Evidence about the induction of sTREM-1 in response to non-infectious pathologies was described in the blood of patients suffering from acute pancreatitis without signs of a bacterial infection [16, 17]. Recent work has also described that the activation of TLRs can be achieved independently of lipopolysaccharides [18]. The activation of TLRs independent of lipopolysaccharides can result in activation of inflammatory signalling through NF-κB or hypoxia inducible factor [19]. As an adaptive response to tissue trauma or resulting tissue hypoxia, NF-κB-dependent or hypoxia inducible factor-1a-dependent pathways might also be activated [20]. This recently described concept could also be an explanation for non-infectious induction of TREM-1 within tissues. In line with this hypothesis, we report here an induction of sTREM-1 following lung contusion - a non-infectious entity that is associated with tissue hypoxia or TLR activation within the affected pulmonary tissue [20].
The interpretations of the results of the present study are limited by several aspects. First, the sampling of BAL fluid via blind suctioning might enhance the variability of the values measured. This method is established and used in several studies for the diagnosis of ventilator-associated pneumonia [8, 21–23] and for the detection of cytokines in the BAL in the context of ventilator-associated lung injury [24]. No data exist, however, on whether the technique of blind suctioning and the collection of samples via bronchoscopy are on a par as far as the measurements of cytokines are concerned.
Furthermore, mechanical ventilation itself stimulates inflammation [25] and might therefore induce increased levels of sTREM-1. Increased sTREM-1 levels could also be explained by bacterial contamination or infection (that is, aspiration on scene). We therefore excluded the BALs of patients positive for intracellular organisms, bacteria or funghi. This approach might be too restrictive, however. since the detection of pathogens in the BAL does not necessarily verify pneumonia. Elevated sTREM-1 levels in the BAL could therefore be theoretically caused by the traumatic injury itself, by inflammation due to mechanical ventilation and by ventilator-associated pneumonia.
Since sTREM-1 levels in the BAL correlate to the severity of trauma, the primary cause of elevated sTREM-1 levels cannot trivially be explained by the mechanical ventilation itself, which in this study followed the same protocol for each patient irrespective of the severity of lung contusion. Furthermore, pneumonia or ventilator-associated pneumonia is not expected to already be present on the day of trauma. This allows us to exclude this reason for sTREM-1 elevation through ventilator-associated pneumonia, since by definition 48 hours of mechanical ventilation are necessary to meet the criteria for ventilator-associated pneumonia.
sTREM-1 also seems to be increased in patients bearing non-infectious processes such as peptic ulcer, inflammatory bowel disease, viral infections, malignant pleural effusions and chronic obstructive pulmonary disease, but also among patients after cardiac surgery or cardiac arrest [4]. Most of the patients included in the study were younger than 40 years of age without relevant comorbidities. One patient anamnestically suffered from asthma bronchiale without daily medical treatment. Complications due to viral infections were not observed within the first 2 days.
Finally, the classification for severity of lung contusion by means of CT scans performed at admission to hospital, which means relatively early after the trauma, might be imprecise. Clinically the severity of lung contusion might differ from radiological visible trauma of the lung in the first hours after trauma. In our population, however, gas exchange parameters correlated negatively with the radiological classified severity of lung contusion. We therefore interpret the classification of lung contusion as a reasonably good indicator for severity of lung contusion in the population investigated.
In summary, the presented data provided evidence that sTREM-1 is expressed during non-infectious inflammation within the lung following traumatic injury. Since the subsequent healing of the lung is to date not well understood, the data from our study indicate sTREM-1 to be an interesting candidate for future investigations into a better understanding of the immunologic processes that are involved after traumatic lung contusion.
sTREM-1 is known to amplify response to bacterial inflammation (pathogen-associated molecular patterns). In the present article, we demonstrate that sTREM-1 is expressed in the course of nonbacterial inflammation following traumatic lung injury.
Key messages
sTREM-1 in BAL is expressed in the course of nonbacterial inflammation following traumatic lung injury
sTREM-1 in the BAL correlates with both the severity of pulmonary tissue damage (radiological) and functional impairment of gas exchange (FiO2/paO2 ratio) after traumatic lung injury
bronchoalveolar lavage
C-reactive protein
computed tomography
enzyme-linked immunosorbent assay
intensive care unit
lipopolysaccharide binding protein
length of stay
nuclear factor
- paO2/FiO2:
arterial oxygen pressure/inspired oxygen fraction
- Rs:
Spearman correlation coefficient
- sTREM-1:
soluble triggering receptor on myeloid cells-1
Toll-like receptor
triggering receptor expressed on myeloid cells-1.
The authors are very grateful to Professor P Rosenberger for proofreading the manuscript. The present study was carried out at the University Hospital Frankfurt am Main and was internally funded. The study is independent of any pharmaceutical interest.
Authors' Affiliations
- Bouchon A, Dietrich J, Colonna M: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000, 164: 4991-4995.View ArticlePubMedGoogle Scholar
- Zheng H, Heiderscheidt CA, Joo M, Gao X, Knezevic N, Mehta D, Sadikot RT: MYD88-dependent and -independent activation of TREM-1 via specific TLR ligands. Eur J Immunol 2010, 40: 162-171.View ArticlePubMedGoogle Scholar
- Jiyong J, Tiancha H, Wei C, Huahao S: Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 2009, 35: 587-595. 10.1007/s00134-008-1333-zView ArticlePubMedGoogle Scholar
- Porfyridis I, Plachouras D, Karagianni V, Kotanidou A, Papiris SA, Giamarellou H, Giamarellos-Bourboulis EJ: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study. BMC Infect Dis 2010, 10: 286. 10.1186/1471-2334-10-286PubMed CentralView ArticlePubMedGoogle Scholar
- Routsi C, Giamarellos-Bourboulis EJ, Antonopoulou A, Kollias S, Siasiakou S, Koronaios A, Zakynthinos S, Armaganidis A, Giamarellou H, Roussos C: Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? Clin Exp Immunol 2005, 142: 62-67. 10.1111/j.1365-2249.2005.02887.xPubMed CentralView ArticlePubMedGoogle Scholar
- Dimopoulou I, Orfanos SE, Pelekanou A, Kotanidou A, Livaditi O: Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes. Inflamm Res 2009, 58: 127-132. 10.1007/s00011-008-7039-4View ArticlePubMedGoogle Scholar
- Gibot S, Cravoisy A, Levy B, Bene M, Faure G, Bollaert P: Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med 2004, 350: 451-458. 10.1056/NEJMoa031544View ArticlePubMedGoogle Scholar
- Determann RM, Millo JL, Gibot S, Korevaar JC, Vroom MB, van der Poll T, Garrard CS, Schultz MJ: Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med 2005, 31: 1495-1500. 10.1007/s00134-005-2818-7View ArticlePubMedGoogle Scholar
- Raghavendran K, Notter RH, Davidson BA, Helinski JD, Kunkel SL, Knight PR: Lung contusion: inflammatory mechanisms and interaction with other injuries. Shock 2009, 32: 122-130. 10.1097/SHK.0b013e31819c385cPubMed CentralView ArticlePubMedGoogle Scholar
- Trentz O, Marzi I: Focus on: diagnostic and prognosis of severely traumatized patients. Eur J Trauma Emerg Surg 2009, 35: 427-428. 10.1007/s00068-009-4005-yView ArticleGoogle Scholar
- Baker SP, O'Neill B: The injury severity score: an update. J Trauma 1976, 16: 882-885. 10.1097/00005373-197611000-00006View ArticlePubMedGoogle Scholar
- Gibot S, Kolopp-Sarda M, Bene M, Bollaert P, Lozniewski A, Mory F, Levy B, Faure GC: A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 2004, 200: 1419-1426. 10.1084/jem.20040708PubMed CentralView ArticlePubMedGoogle Scholar
- Ford JW, McVicar DW: TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009, 21: 38-46. 10.1016/j.coi.2009.01.009PubMed CentralView ArticlePubMedGoogle Scholar
- Ornatowska M, Azim AC, Wang X, Christman JW, Xiao L, Joo M, Sadikot RT: Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol 2007, 293: L1377-L1384. 10.1152/ajplung.00140.2007PubMed CentralView ArticlePubMedGoogle Scholar
- Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S: TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. J Immunol 2009, 183: 2027-2036. 10.4049/jimmunol.0803862View ArticlePubMedGoogle Scholar
- Yasuda T, Takeyama Y, Ueda T, Shinzeki M, Sawa H, Takahiro N, Kamei K, Ku Y, Kuroda Y, Ohyanagi H: Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis. Crit Care Med 2008, 36: 2048-2053. 10.1097/CCM.0b013e31817b8824View ArticlePubMedGoogle Scholar
- Ferat-Osorio E, Wong-Baeza I, Esquivel-Callejas N, Figueroa-Figueroa S, Duarte-Rojo A, Guzman-Valdivia-Gomez G, Rodea-Rosas H, Torres-Gonzalez R, Sanchez-Fernandez P, Arriaga-Pizano L, Lopez-Macias C, Robles-Diaz G, Isibasi A: Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis. Crit Care 2009, 13: R69. 10.1186/cc7876PubMed CentralView ArticlePubMedGoogle Scholar
- Mersmann J, Berkels R, Zacharowski P, Tran N, Koch A, Iekushi K, Dimmeler S, Granja TF, Boehm O, Claycomb WC, Zacharowski K: Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury. Crit Care Med 2010, 38: 903-909. 10.1097/CCM.0b013e3181ce50e6View ArticlePubMedGoogle Scholar
- Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V: Cutting edge: essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis. J Immunol 2007, 178: 7516-7519.View ArticlePubMedGoogle Scholar
- Eltzschig HK, Carmeliet P: Hypoxia and inflammation. N Engl J Med 2011, 364: 656-665. 10.1056/NEJMra0910283PubMed CentralView ArticlePubMedGoogle Scholar
- Kollef MH, Bock KR, Richards RD, Hearns ML: The safety and diagnostic accuracy of minibronchoalveolar lavage in patients with suspected ventilator-associated pneumonia. Ann Intern Med 1995, 122: 743-748.View ArticlePubMedGoogle Scholar
- Campbell GDJ: Blinded invasive diagnostic procedures in ventilator-associated pneumonia. Chest 2000, 117: 207S-211S. 10.1378/chest.117.4_suppl_2.207SView ArticlePubMedGoogle Scholar
- Flanagan PG, Findlay GP, Magee JT, Ionescu A, Barnes RA, Smithies M: The diagnosis of ventilator-associated pneumonia using non-bronchoscopic, non-directed lung lavages. Intensive Care Med 2000, 26: 20-30. 10.1007/s001340050007View ArticlePubMedGoogle Scholar
- Determann RM, Royakkers A, Wolthuis EK, Vlaar AP, Choi G, Paulus F, Hofstra J, de Graaff MJ, Korevaar JC, Schultz MJ: Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care 2010, 14: R1. 10.1186/cc8230PubMed CentralView ArticlePubMedGoogle Scholar
- Terragni PP, Rosboch G, Tealdi A, Corno E, Menaldo E, Davini O, Gandini G, Herrmann P, Mascia L, Quintel M, Slutsky AS, Gattinoni L, Ranieri VM: Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 2007, 175: 160-166.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Valor introduces CrossFit Training Rigs
Michael B
These items are highly customizable. Perfect for Gyms/Home Gyms/Garage Gyms. CrossFit enthusiasts will love these configurations. With many options there is numerous configurations to suit your needs. Wall Ball /Pull up/Land Mine options available. Solid and Commercial grade. You can start small and add options as you grow. Please check them out here https://fitnessgearusa.com/collections/rg
Welcome to our NEW SITE!
After 5 years we have finally decided to change platforms and build the website from the ground up. The new site features the latest in inventory tracking and automation. This allows us to better server our clients and provide a much better shopping experience. With the new systems in place , we can now bring on a bunch of new products and vendors, expanding our selection even more. Please let us know what you think, we welcome suggestion on products and store design ideas. Thank you!


text:
Bring all of your project information together, and then export the data as a PDF or spreadsheet.Watch the video
Search through articles relevant to your industry.Read now
Schneider Electric Australia Website×
Thanks for visiting our website!Confirm your location Choose another country or region
Explore our global offerings or select your country from one of our five regions.Global
Découvrez nos offres globales ou sélectionnez votre pays dans l'une de nos cinq régions.
No. There are two reasons preventing a potentiometer, part number SZ1RV1202, from being installed in an XACA enclosure:
1. An SZ1RV1202 potentiometer requires a 10.5 mm drill hole for installation, whereas the enclosure has a 22.2 mm drill hole
2. The intermediate metal contact fixing plate does not leave enough space below the front panel for the potentiometer body
Solution: Use the XACB or XACM boxes with ZB5AD912 (6mm potentiometer shaft) or ZB5AD922 (6.35mm, 1/4" shaft).
It is necessary for the user to supply the potentiometer as it is not supplied with the heads. The potentiometer should be 2.2K Ohm linear, with a shaft length of 45 to 50mm. A rating of 2 Watts is recommended for VSD applications though 1/2 Watt or more should be fine and will be much more compact.


text:
The Ghost Writer is so rich you may feel you paid too little for your ticket when the whole thing meets its very Polanski-ish climax. Please don't tell anyone. show more
Loaded with Hitchcockian hugger-mugger, this is a genre Polanski clearly revels in. show more
All credit to a finely tuned Brosnan for packing so much intensity and wayward wit into his scenes with McGregor. Their verbal duels make for a dazzling game of cat-and-mouse. show more


text:
Top right corner.
Remember Stax is in Japan.
Top right corner.
Remember Stax is in Japan.
LOL! Didnt even notice it there hahaha
from the thread
Regarding Beats Studios:
Home of the Liquid Carbon, Liquid Crimson, Liquid Glass, Liquid Gold and
Liquid Lightning headphone amplifiers... and the upcoming Liquid Spark!
From the deals thread, PurpleAngel posted a deal on an Antec power supply
So since a lot of people like to bump uglies while listening to music, I should feel free to post deals on condoms?
Q701 is good. The HD558 and 598 are good. The HD600 and HD650 are even better. You can buy them used for a little bit more than $250.
IMO, the HD700 does some great things, but it also does some really bad things.The HD650 and HD600 are like fairly good looking cute girls. There's absolutely nothing wrong with them and one can be extremely content and very happy. The HD700 is kind of like a really hot chick, but with a [redacted].
^^ same thread
FKn hilarious
Oh my god. Just when I thought I couldn't love this forum any more than I did...then I found this thread :)
|Originally posted by Music Fanatic
Well, I don't follow our arithmetic(unless by shortly you mean 23 months), but I do appreciate your sharing this link to the K1000 service manual.
See bmeat's posts on the past 20 pages or so.


text:
Receive information about new products and educational opportunities, as well as, exclusive offers only available to subscribers!
   |  View Online Catalog   |   To Order 1-888-918-2253
Log In My Account
I'm only a part-time massage therapist, and these stones were a bit of an expense. With that said, I love them and my hot stone clients do too! Using traditional stones were difficult for me because my hands could not take the heat. My hands are also smaller and using the larger stones were difficult. As a therapist, I felt I spent more time trading out stones than I did with my client. It took a couple of sessions to get use to a new routine (no stone flipping needed) but my clients commented on how the stones remained a consistent temperature with each pass. The stones heat quickly (from inserting the battery to use I let them warm for 5mintues as I prep). The instructions were a disappointment. There were no charging times or heating times in the booklet, I had to search online. I let mine charge the 8hrs I'm at work then I pack everything up and plug them in at the client's house.
Instead of writing negative comments, why don't you contact the Manufacturer. This stone has worked as indicated for me. Make sure you allow it to charge completely prior to use. And I would think if you drop or otherwise misuse, it might chip or break! It is made of stone!!
Made the hot stone massage so much easier and more efficient!!
I have been using the red stone. It has been a big hit with my clients. I incorporated it with all my massages
1-I did not realize that only one side of the stone heated.
2- The stone loses its heat completely after about 30 sec on the skin
...the worst massage product I have bought yet.
©2017 Massage Warehouse - Massage Tables, a division of Scrip, Inc
Privacy Policy


text: The Commodity Futures Trading Commission is preparing a guide for reining in high-frequency trading. It could be released as early as next week. The guide discusses ideas such as labeling HFT firms so regulators can more closely examine their trades, as well as scrutinizing fees and incentives that might distort the market.


text:
VPN Multihop (Chain) Program using OpenVPN
This project received 3 bids from talented freelancers with an average bid price of $416 USD.Get free quotes for a project like this
Project Budget$250 - $750 USD
Total Bids3
Project Description
I need a VPN Multihop (Chain) Program created. It needs to be able to connect through multiple VPN's that use OpenVPN.
This needs to be like how [url removed, login to view]'s VPN Multihop is, you can connect to one of their vpns that connects to two different locations thus making your online experiences more anonymous. But rather then doing that all from one company i want to be able to purchase multiple OpenVPN services from different companys then connect to two or three different vpn services. I know at the end the speed on the internet will be pretty slow but that's ok.
Please only bid if you are positive you can code a program like this.
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Killer Mike Net Worth: Killer Mike is an American hip hop recording artist and actor who has a net worth of $5 million. Killer Mike was born in Atlanta, Georgia in April 1975. Killer Mike is the founder of Grind Time Official Records. His debut came on the track "Snappin' and Tappin'" on OutKast's 2000 album Stankonia. Mike later appeared on OutKast's Grammy winning single "The Whole World" from their greatest hits album. Killer Mike signed to rapper T.I.'s Grand Hustle Records in 2008. His debut studio album Monster was released in March 2003 and reached #4 on the US R&B and #10 on the Billboard 200 charts. He has released six solo studio albums with his latest R.A.P. Music coming in 2012. Killer Mike has also released the albums Run the Jewels in 2013 and Run the Jewels 2 in 2014 with rapper-producer El-P. He has also released four mix tapes. Mike's best known single is "A.D.I.D.A.S" (featuring Big Boi and Sleepy Brown) which charted in the US, Ireland, New Zealand, and the UK. Mike opened Graffiti's SWAG Barbershop in 2011. He has appeared in the movies 20 Funerals, Idlewild, and ATL.
Killer Mike Net Worth
Killer Mike
Date of Birth
Apr 20, 1975 (41 years old)
Rapper, Actor, Voice Actor, Film Score Composer
United States of America
More Actors
All net worths are calculated by applying a proprietary algorithm. The results are then fact checked and confirmed by a team of editors. We scan all publicly available data and resources and work diligently to ensure that our numbers are the most accurate and up to date net worth data you will find anywhere on the internet.


text:
PlayStation Help
Sign In
[color=blue]I sent you the entire walkthrough and it should answer all of your questions. I hope that the info was of any help to you. Well, enjoy posting and have fun gaming.[/color] :thumbsup:
Howdy, Stranger!
It looks like you're new here. If you want to get involved, click one of these buttons!
Sign In
Apply for Membership
Powered by Vanilla


text:
Wonderful product
Verified Purchase
Wonderful product
The perfect suntan oil. Smells amazing, feels super hydrating. Definitely a must-have for summer.
Posted by Reviewer1983375 on Jan 20, 2012
This product smells so nice. I used to use it when I was 16. I am now 58 and was so excited to find it still around. I use a sunscreen when in the sun but use this after my shower. This is the best stuff ever.
From Russian Federation
Posted by Reviewer1224729 on Sep 21, 2012
oil is pleasant smell delicious одно удовольствие пользоваться масла данной марки
Wonderful product
The perfect suntan oil. Smells amazing, feels super hydrating. Definitely a must-have for summer.
Posted by cielava on Nov 05, 2010
Beautifull smell!
Grate tanning oil!
Posted by Reviewer1428695 on Jun 01, 2011
It smells delicious and is the best by far!
Love it
Posted by Reviewer1470632 on Aug 15, 2011
Love the smell
heavenly oil, amazing smell, absorbs well
Posted by 5626590983559425517 on Jun 12, 2016
will definitely buy again!
Very Good
Posted by YuliaBlum on Sep 11, 2013
Smell to kill :). I like it very much. And tan with it, a much prettier and faster than without it.
A must have
Posted by Reviewer3088995 on Sep 22, 2009
This is my third order for this product, it is awesome!!!! I take it to the beach all the time. My skin feels amazing and the tan I get is the best. Also try the Vanilla Oil.
Posted by Reviewer1959050 on May 15, 2010
Skin feels soft. And it also smells good


text:
You missed it This great deal for Beyond a Classroom is over. But don't despair, we've got more great deals every day.
Related Deals That You May Like
Beyond a Classroom
Sharpen Studying Skills with an Online Course
Set students up for success with this online course, which focuses on studying strategies designed to boost efficiency and comprehension:
• $99 ($399 value) for a "Study and Work Smarter, NOT Harder®" online course
• Six-class series meets once weekly at night; each focuses on a single topic
• Designed for grades 5 through 12
What You'll Learn
Led by an accomplished educator, the course covers time management and creating schedules; organization and optimal study environments; note-taking strategies and tools; understanding your learning style; test-taking tactics; and goal-setting and progress-tracking systems.
Beyond A Classroom's Website
PAID VALUE EXPIRES ON February 25, 2022
PROMOTIONAL VALUE EXPIRES ON November 17, 2013


text:
Openings (Click the title for more info):
Mar. 3: The Red Turtle
Mar. 3: The Salesman
Mar. 3: XX
Mar. 3: A United Kingdom
Mar. 4: My Life As A Zucchini
Mar. 31: The Zookeeper's Wife
Mar. 31: Land of Mine
April 7: Frantz
Closing Tuesday, Feb. 28:
Closing Thursday, March 2:
La La Land
Oscar Nominated Short Films
The Lure
Closing Thursday, March 9:
I Am Not Your Negro
One Take Doc Series
Mar. 14 and 18: Mr. Gaga
April 11 and 15: Sacred
*Openings and closings are subject to change
This is not a complete list of openings
Support for The Little Theatre comes from:
Annual Business Partner Support provided by:


text:
Should you buy these stocks too?
What would it take to make you feel wealthy?
Join the NASDAQ Community today and get free, instant access to portfolios, stock ratings, real-time alerts, and more!
Swiss pharmaceutical giant
) reported earnings per share of $1.23 for the fourth quarter of
2011, marginally beating the Zacks Consensus Estimate of $1.22.
Earnings were also above the prior-year figure of $1.14 per share.
An unimpressive top-line was countered by higher adjusted operating
income resulting in the nominal beat.
Reported earnings were only $0.49, down 48% year over year, due
to huge exceptional and one-time charges of $1.5 billion in the
quarter. The exceptional charges related primarily to the
Tekturna/Rasilez sales decline, discontinuation of some pipeline
candidates and temporary suspension of production at the Lincoln,
Nebraska facility.
Fourth quarter revenues of $14.8 billion fell short of the Zacks
Consensus Estimate of $15.0 billion mainly due to poor performance
of the Sandoz and Consumer Health segments. Foreign exchange
further affected fourth quarter revenue by 1%. Revenues were
however ahead of $14.2 billion recorded in the year-ago period.
For the full year 2011, Novartis announced earnings of $5.57 per
share, slightly below the Zacks Consensus Estimate of $5.63.
Revenues were $58.6 billion, minimally below the Zacks Consensus
Estimate of $58.8 billion. Revenues, however, grew 16% and earnings
were up 8% over the prior year.
The Fourth Quarter in Detail
Novartis operates in five segments. The financial details from
these segments are discussed below.
Pharmaceutical division
sales were up 4% to $8.3 billion in the quarter. Growth from volume
expansion and new product launches (accounting for 30% of
Pharmaceutical sales) was partly offset by price erosion, the
negative impact of patent expirations and product divestments.
Oncology sales growth of 1% was led by some established products
like Gleevec (up 8% to $1.2 billion) and Sandostatin (up 7% to $374
million) as well as new products like Tasigna (up 64% to $207
million) and Afinitor (up 66% to $133 million). Femara sales (down
62% to $134 million) were negatively impacted by generic
The Cardiovascular and Metabolism franchise recorded a sales
decline of 8% due to weakness in Diovan (down 16% to $1.3 billion)
and Tekturna (marketed as Rasilez outside US)(down 19% to $108
million). Novartis' blockbuster hypertension drug Diovan loses
patent expiration in the US in September 2012 and is already facing
generic erosion in the European Union (
). Diovan will greatly weigh upon Novartis' top line once its
patent expires. Tekturna sales were hit by the failure of the
ALTITUDE study. In December 2011 Novartis announced that it has
stopped the ALTITUDE study which was investigating Tekturna/
Rasilez in a high-risk population of patients with type-II diabetes
and renal impairment following recommendation from a Data
Monitoring Committee. As a result, Novartis is recommending against
use of Rasilez/Tekturna-based products in combination with an
angiotensin converting enzyme (
) inhibitor or angiotensin receptor blocker (
) in hypertensive patients with diabetes. It has ceased promotion
of any such combination medicines.
The Neuroscience and Ophthalmics franchise experienced a 33%
increase led by eye drug Lucentis (up 40% to $550 million) and new
multiple sclerosis drug Gilenya, which recorded revenues of $203
million. The respiratory franchise recorded a growth of 20%
driven by Onbrez Breezhaler (up 88% to $32 million) and Xolair (up
27% to $130 million).
Last year, Novartis completed the merger with Alcon following
which Alcon became the second largest division within Novartis. The
Alcon Division
recorded revenue of $2.4 billion in the quarter, representing a
pro-forma growth of 6% driven by strong growth of ophthalmic
pharmaceuticals and surgical products.
, Novartis' generic arm, recorded a sales decline of 5% to $2.3
billion as growth from volume expansion was offset by price
erosion. Moreover, the generic version of
's (
) Lovenox was down year over year, which significantly impacted
Sandoz' US retail generics and biosimilars growth. Softer pricing
resulting from increased competition affected generic Lovenox
sales. The volume growth was driven by strong performances in
France, Spain, Russia, Italy and Japan as well as from
Sales at the
Vaccines and Diagnostics
division grew 86% over the year-ago quarter to $671 million. Strong
performance of meningococcal vaccines (particularly Menveo), brisk
diagnostics sales and resolution of shipment delays (which affected
prior quarters) drove the upsurge. One time revenue from
pre-pandemic flu vaccine also boosted sales in the quarter.
Consumer Health
sales were down 7% over the prior year to $1.1 billion due to
weakness in sales of over-the-counter (OTC) products. In early
January 2012, Novartis issued a voluntary recall for certain OTC
products in the United States, following the temporary suspension
of operations from its Lincoln, Nebraska facility which affected
OTC sales. The Animal Health division however did well in the
2012 Guidance
Novartis expects 2012 total constant currency sales to be in
line with 2011 levels. The newly launched products are expected to
make up for Diovan generic erosion, decline in Tekturna/Rasilez
sales, price erosion and ongoing issues at the Lincoln plant. The
Lincoln plant would resume shipments in mid-2012. Management
expects to lose about $1.2 billion in Diovan sales in 2012. This
combined with the Femara patent expiration will affect
Pharmaceuticals revenue by about $2.6 billion. Moreover, Tekturna/
Rasilez sales are forecast to be reduced to half of what they are
in 2011.
Novartis estimates a year-over-year decline in core operating
margins (in constant currencies) in 2012 due to pricing pressure,
generic competition and the suspension of operations at
Our Recommendation
Currently, we have a Neutral recommendation on Novartis. The
company carries a Zacks #3 Rank ("Hold" rating) in the short run.
Though pleased with Novartis' wide range of products and its
business diversity, we prefer to remain on the sidelines in the
long term due to the imminent patent cliff faced by the
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.
Enter up to 25 symbols separated by commas or spaces in the text box below. These symbols will be available during your session for use on applicable pages.
You have selected to change your default setting for the Quote Search. This will now be your default target page;
unless you change your configuration again, or you delete your
cookies. Are you sure you want to change your settings?


text:
The Windows Phone FreePrints photo printing and ordering app, which had been removed from the Windows Phone Store and was going to shut down on March 1, will be coming back after a outcry from many users. The company sent out an email apologizing for their earlier decision.
Shop: Surface Studio | New Surface Book | Xbox One S Bundles | NEW Dell XPS 13"


text:
About IDS Brazil
IDS Brazil is one of the four global subsidiaries of IDS, Ingegneria dei Sistemi, the leading high-tech solution provider in defence and civil niche market sectors.
Building on the experience and expertise of around 500 worldwide employees, IDS Brazil offers its customers skills & competences, advanced services and constant and continuous assistance in order to support its clients in executing successful projects.
Founded in 2006 in San Paolo, Brazil, IDS Brazil has been fundamental for the commercialisation of IDS solutions in Latin America. Covering all the business lines of the head office, IDS Brazil provides its customers with the most advanced solutions available on the market for the Unmanned, Radars, Aeronautical, Air Navigation and Naval sectors.


text:
Golden Kanye/Jesus Appears in Los AngelesThe street art is the latest piece by the sculptor Plastic Jesus.
Watch James Corden's Soap Opera Featuring Only Kanye West Lyrics"The Bold and the Lyrical" features Bryan Cranston and Jessica Biel as the bride and groom and Corden as the drunk audience member.
Kim Kardashian Returns to Social Media with Family Photo, VideoThe posts feature husband Kanye West and children North and Saint.
Kanye West Dyes Hair Rainbow, Twitter ReactsKanye West has made headlines once again. This time, though, it's about his hair.
Kanye West Fills Us in on His Conversation with Donald TrumpWest met with Trump to discuss multicultural issues.
10 Songs Kanye West Should Play at Trump's InaugurationCould Kanye put on the inaugural event that the country needs? We dive into his lyrics to find out.
Kanye West Takes a Meeting With Donald TrumpWest is slightly underqualified for a Cabinet-level position or Supreme Court nomination. But it's not unthinkable that West could perform at the inauguration.
Kanye West's 'Famous' Video Recreated by Instagram-Famous DogsWhat transpires is a nearly shot-by-shot remake of West's original video. The dogs are all covered in tiny red and white sweaters, protecting their modesty.
John Legend Was 'Concerned' About Kanye West Before HospitalizationLegend and his wife Chrissy Teigen are good friends with Kanye and wife Kim Kardashian.
Kanye West in Talks with Will Ferrell to Write Biopic?It's a big rumor, but oh how we wish it was true.
Welcome to Kanye WestWorldJimmy Kimmel shared his parody of the new series 'Westworld,' re-cutting its trailer to include Kanye.
Kanye's Instagram Debut Earns 1 Million FollowersKanye West had barely spent one day on Instagram when his account crossed the 1 million follower milestone.


text:
The Best of the Music & Art Scene In New York From A to G. Daily!
Posted by The G on November 26, 2011 under Street Art | Be the First to Comment
Photo by G.
Don't worry. I had the same reaction!
Tags: 2011, Fiddlestixx, Los Angeles, Photo, Sticker, Street Art
Name (required)
Mail (will not be published) (required)
Notify me of follow-up comments by email.
Notify me of new posts by email.
Like A2G on Facebook!
© 2017 According 2 G | All Rights Reserved


text:
While Nariida and Sojana (GBR), owned by Peter Harrison, were almost equally positioned 48 hours ago, Nariida has now lengthened her lead and at 14.30 UTC today was approximately 100 nautical miles closer to the finish line than her British rival. Andrè Auberton's Dark Shadow (MON), was in third place.
Will Apold's Valkyrie (CAN) had moved up to fourth place after choosing a southerly route and was followed by Bernd Kortum's Julie Marie (GER) and Anders Johnson's Blue Pearl (GBR),with these last two practically neck-and-neck. Zefiro (GER), owned by Gerhard Ruether, rounded up the fleet.
Will Apold's last update showed the typical good spirits this Canadian crew has displayed form the start despite having some equipment problems: 'We are sailing a southerly approach to the finish having been first to dive south to get under the mixed weather ahead. The weather conditions are superb.
The weather at present is 20 knots from the east allowing Valkyrie to slide off the waves adding to its speed. Valkyrie has had its gear problems since this is the second race for the boat so there have been gear issues including the loss of a halyard resulting in the dropping of the spinnaker over board.
The kite was recovered and the minor damage repaired. We lost our heavy A5 Chute when the head separated from the body resulting in a second 'ALL HANDS ON DECK' Crew members arrived in various states of dress or undress as we struggled to pull the chute in board. The chute was recovered but is damaged beyond repair for the facilities on board.'
Although this is the first time they have all sailed together, he is confident in his crew's ability: 'The crew is all from the Halifax area of Nova Scotia on the east coast of Canada and have been normally sailing against each other in small boats. Ten of the 13 crew are members of the Bedford Basin Yacht Club and two of the others are former members. This is the first time that this group has sailed together on Valkyrie although they are familiar with each others sailing styles. As we say in Canada, 'Now it is up to us to put the puck in the net!' The crew is pumped and we are sailing well.'
The prize giving for the event is scheduled to take place on 14th December in St Maarten and will see the overall winner under IRC handicap receiving the Rolex Trophy and timepiece. There will also be trophies for the winner in real time and the first IMA member under handicap.


text:
ci3PhotograpyPhotographer Male San Antonio, Texas, US
My Website: Ci3pMy MM URL: http://www.modelmayhem.com/Ci3p
Mayhem # 84821
About Me
Ci3 Photography is located in San Antonio, TX. Ci3 Photography has been providing professional photography since 2006. We specialize in Modeling, Portraits, Commercial, and anything else you need a professional photographer at. We have contracts with several national magazines to provide insights on professional photo advice as well as provide high quality work. Ci3 Photography is a member of WPPI and PPA.
Have you worked with ci3Photograpy? Add Credits for ci3Photograpy! >>
See Sample Worked together 1 times; Most recent: April 2016
Zach Howell
"Carlos is a great photographer! Very willing to help and teach as he can. His studio is very clean and he has everything he needs ready to go. His photos turn out great and I have gotten a decent amount of exposure from working with him as well!"
See Sample Worked together 2-10 times; Most recent: April 2016
"Amazing photographer and a great guy. I love working with ci3Photograpy"
See Sample Worked together 2-10 times; Most recent: March 2016
Angel Miramontes
"Carlos and I worked in several projects. He is an amazing photographer and very passionate. I can't wait to be in San Antonio and shoot with him again."
See Sample Worked together 2-10 times; Most recent: September 2015
The David Quiroz Model
Righteous Filben Model
joshyyyy92 Model
Isaac N Maceyra Model
Josh Milks Model
Anthony Leija Rodriguez Model
Loading Content


text:
Lauryn Hill »
Lauryn Hill & The Weeknd Connect For Their First Live Performance Together On 'The Tonight Show' (Video)
Lauryn Hill kind of comes & goes these days in the industry. Fans & spectators were expected to see the Hip-Hop goddess join The Weeknd on stage during the Grammy's this year, but someoneRead More »
Lauryn Hill – A Cradle In Bethlehem
On January 1st and 4th, Lauryn Hill will be performing at The Howard Theatre in Washington DC and The Brooklyn Bowl in NYC. To prep her core fans for her upcoming shows, she decidesRead More »
Lauryn Hill Performs "I Gotta Find Peace of Mind" During One Music Fest 2015 (Video)
There are very few women in music who have had the impact that Lauryn Hill's story and message has had in our culture so the experience Ms. Lauryn Hill provides when performance is trulyRead More »
Lauryn Hill Gives Nina Simone Tribute Live On The Tonight Show (Video)
Last night on The Tonight Show, a special tribute performance was given to ms. Nina Simone by the legendary Lauryn Hill. With it being very seldom for Lauryn to make any mainstream TV appearances, her performance wentRead More »
Usher – My Baby Just Cares For Me
On Friday Netflix will be debuting What Happened, Miss Simone? Lauryn Hill, Jazmine Sullivan, Mary J. Blige, Common, Lalah Hathaway, Lisa Simone, Usher, and more have contributed new music and covers of Nina SimoneRead More »
Lauryn Hill Covers Nina Simone's Feeling Good
Netflix will be bringing us a documentary about Nina Simone. For What Happened, Miss Simone?, Lauryn Hill paid tribute to Nina as part of the project. Ms. Hill recorded six sounds for the filmRead More »
Lauryn Hill x The Roots x A$AP Rocky x Janelle Monae & More Set To Perform At The 2015 ONE Musicfest
Atlanta, we are in for another great show to end the Summer right. ONE Musicfest, in partnership with Live Nation has just released the 2015 music lineup for one of the most anticipated festivalsRead More »
Lauryn Hill's Legendary Album "The Miseducation Of Lauryn Hill" Is To Be Inducted Into The Library Of Congress
The Miseducation Of Lauryn Hill serves as the only solo project produced out of the phenomenon in which we know to be Miss. Lauryn Hill. That project alone earned her 5 Grammy Awards andRead More »


text:
Rates in SGD (taxes & fees included), shown as:
Nightly Average
Premier Deluxe Hotel and Spa
1, Ahmad Rajabli Str.., Baku 1052, Azerbaijan
Find Hotel Rates
Recent Searches
Wego searches multiple travel sites so you can find and compare the best rates.
Premier Deluxe Hotel and Spa Hotel Reviews
Based on reviews from across the web.
Premier Deluxe Hotel and Spa Hotel Details
Check-in: 14:00
Check-out: 12:00
This property enjoys a convenient location in Baku . Hotel was built in 2012. There are a total of 36 rooms on the premises. The property consists of 9 double rooms, 9 junior suites and 18 suites. The Hotel is within easy reach of the city's main bus and train stations.
1, Ahmad Rajabli Str.. Baku 1052, Azerbaijan


text:
We are so confident that you will be more than satisfied with your purchase, we are providing a 100% Money Back Lifetime Guarantee so you can try it at NO RISK!
Every serving of Healthy Resolve gives you what ordinary multivitamin formulas don't, including:
Highly available forms of vitamin A and vitamin E
Vitamin D3, or Cholecalciferol — the body's natural form of vitamin D. D-3 is real vitamin D, and is synthesized naturally in the skin.
Complete B vitamin profile.
A highly absorbable form of calcium, calcium citrate. Studies show it's up to 10 times better absorbed when compared to calcium carbonate, the commonly used form of calcium.
Tocotrienols and citrus bioflavonoids that provide hesperidin, quercetin, and rutin for added antioxidant support, and
Trace essential minerals including magnesium, zinc, copper and boron.
Plus, Healthy Resolve uses amino acid chelates for its minerals. Many other multivitamin formulas don't use them at all.
In an amino acid chelate form, the mineral is bound to an amino acid. That aids absorption through the small intestine.
Healthy Resolve is manufactured in the USA from globally sourced ingredients by Formulation Technology, Inc. in a facility that is GMP registered by NSF® International.
Healthy Resolve gives your body nutritional support in one easy, convenient formula - for just pennies a day!
Serving size 6 Tablets
Servings per Container 30
Amount Per Serving
% Daily Value
Vitamin A (5,000 I.U. as vitamin A palmitate and 10,000 I.U. as natural mixed carotenoids from D. salina)
Vitamin C (as L-ascorbic acid, corn free and calcium ascorbate)
1,200 mg 2,000%
Vitamin D-3 (as cholecalciferol)
Vitamin E (as d-alpha tocopheryl succinate plus mixed tocopherols)
Thiamine (vitamin B1) (as thiamine
50 mg 3,333%
Riboflavin (vitamin B2)
50 mg 2,941%
Niacin (as niacinamide and niacin)
100 mg 500%
Vitamin B6 (as pyridoxine hydrochloride)
100 mg 5,000%
Folic Acid
500 mcg 125%
Vitamin B12 (as cyanocobalamin on ion exchange resin)
125 mcg 2,083%
300 mcg 100%
Pantothenic Acid (as d-calcium pantothenate)
100 mg 1,000%
Calcium (as calcium citrate and calcium ascorbate)
500 mg 50%
Iodine (from kelp)
250 mcg 167%
Magnesium (as magnesium aspartate-ascorbate complex and magnesium glycinate chelate)
500 mg 125%
Zinc (as zinc glycinate chelate)
15 mg 100%
Selenium (as selenium amino acid complex)
200 mcg 286%
Copper (as copper glycinate
2 mg 100%
Manganese (as manganese glycinate chelate)
10 mg 500%
Chromium (as nicotinate glycinate chelate)
200 mcg 67%
Molybdenum (as molybdenum
glycinate chelate)
50 mcg 67%
Potassium (as potassium
aspartate-ascorbate complex)
99 mg 3%
Boron (as boron aspartate-citrate)
2 mg *
Vanadium (as vanadyl sulfate)
30 mcg *
Choline (as choline bitartrate)
150 mg *
50 mg *
PABA (para-aminobenzoic acid)
50 mg *
Citrus Bioflavonoids (100 mg as hesperidin complex, 50 mg as lemon bioflavonoid complex, 50 mg as quercetin, and 50 mg as rutin)
250 mg *
Alpha-Lipoic Acid
25 mg *
Tocotrienol Complex
20 mg *
Other Ingredients: Vegetable stearine, silica, (vegetable cellulose sodium, cellulose, vegetable gum, calcium stearate, rice extract vegetable cellulose, titanium dioxide, natural citrus flavor, and riboflavin coloring
Click image to enlarge
6 Reviews | 4.5 Average Rating | 83% Recommend This Supplement


text:
Truth in Theater: The Mike Daisey panel
Mike Daisey's The Agony and the Ecstasy of Steve Jobs set off a charged debate at the Public Theater. Here, for the first time, is a full transcript.
Wed Jul 25 2012
Photograph: Joan Marcus
Adam Feldman: Jason, I guess we'll start with the two journalists on the panel.…
Jason Zinoman: One reason I think this is a great thing that Adam put together is that most of this discussion is going on between people who have seen very little of Mike Daisey's work, or know very little of it, or know very little about the theater, and I tend to think that the people who've seen his work…we can have a more informed discussion about this distinction. Because it's actually…I find this distinction unsatisfactory for a different reason, which is that if you say, Mike Daisey, "I'm theater, not journalism"—he is not a traditional theater artist, his process is very different than most theater artists. He doesn't have a script is the most obvious start, which a lot of people don't realize; it changes every day. His process is actually much more similar to a stand-up comic than anybody else, in that he builds the show onstage. So within the realm of theater, he is an anomaly. He calls himself not an actor or a playwright; He calls himself a storyteller. And as it happens, I'm working on a story right now about this genre, which is both the oldest genre in the world, storytelling, but is also a fairly new genre, which is a subgenre of comedy and theater—and even within that world, Mike Daisey is an anomaly, for reasons that are varying. What I take from this is that to judge whether or not it was right or wrong what he did, we need to look not at these simplistic labels, although I think labels on how the theaters promote these shows matter. We need to look at actually what his intent is, what his process is, and what is the unspoken contract that he has with an audience, and in that sense, he's identical to a journalist because journalists and theater people have this unspoken contract with their audience. And if you break it, I know in journalism, as someone who was at the Times right after Jayson Blair, I worked a summer at The New Republic with Stephen Glass, there's nothing more important. There's nothing that can be more damaging than losing your credibility of your reader.
Adam Feldman: Okay. When you introduced him, though, you said he works like a stand-up comic. Now if you're watching Sarah Silverman onstage, and Sarah Silverman tells jokes onstage, in the persona of Sarah Silverman, playing a version of Sarah Silverman that you kind of know is not really Sarah Silverman, if she makes a joke, and we say, "Wait a second, Sarah Silverman's last boyfriend wasn't Mexican. She's lying!"—aren't we making a mistake about the nature of stand-up comedy? [Pause] Shall we answer that, or…? [Laughter]
Jason Zinoman: I don't think Mike, in his form, is like stand-up comedy. His process is like stand-up comedy. There are serious differences between Mike Daisey and Sarah Silverman [Laughter]—although they're both funny, no question. But I think that Mike Daisey's goal, clearly with this show, or one of his goals, is to say, "I went to this place, I saw these things," and there's a certain authority he has from saying that. And he says, in his recent Georgetown speech, "I wanted to take this out of the theater." This issue of the theater, this distinction, almost seems less relevant a couple days later. I don't think that's his main argument anymore. He clearly wanted to make change. He was thinking, as I see it, as much like an activist who was passionate about these labor conditions. And Sarah Silverman just wants to make you laugh.
Peter Marks: Beyond that, I looked at that as that, when he said that as, kind of…that's kind of the ideal for a theater artist. They want to take it outside the theater. What makes you feel like you're having an impact on the world more than it moving beyond the theater? That's what the Civilians' and Jessica's work does. It's an absolute attempt to do that. So I didn't see that as necessarily a damning thing. I thought that was something that ennobled what he was attempting.
Adam Feldman: There are a lot of different branches for this discussion. But in terms of this particular piece, Mike says very specifically in that Georgetown speech, which is available online, he says it was an activist project; he says it was different from other things that he's done, and one of the things that's so different about it is that there is a script that he created, and that was distributed, downloadable, through This American Life. And I wonder, if it hadn't been Mike Daisey giving this speech—I mean, if this play was available as a play, which it was, and if you saw some college student in a college town, saying, "I went to China and I met this person," wouldn't you know that it was a play? In a way that you don't when Mike Daisey himself is delivering it? And is that a factor in this conversation? Sorry, I know I'm throwing it onto a different subject.…
Steven Cosson: Can the artist just answer the first question?
Adam Feldman: Yes! Yes.
Peter Marks: No! [Laughter]
Steven Cosson: I'll join in as Artist No. 1. I think I basically agree with what Peter said, but then I'm going to say I disagree—which is, I think there are different rules for theater that engages reality and has some overlap with journalism, and journalism per se. And then I'll get into the nuances. But I think, ultimately, I fundamentally agree with Oskar's statement, that whatever the work is, that there's an explicit or an implicit contract made with the audience in the frame of the work that tells the audience the relationship of the work to actual fact. And so within the world of what's called documentary theater, or theater based on memoir or verbatim theater or theater drawn from interviews or investigative theater (which is how I often describe what I do) or all the many different forms in that world, they all live on a pretty broad spectrum, I would say. From one pole, I would say, that says that theater is really functioning as journalism—I think there's a pole where the frame of the play, the contract with the audience, is saying, "This actually happened, I witnessed this, this story is true, I went to such-and-such a place, I saw a big blue elephant," and you want to believe—the agreement is—that big blue elephant was really there. And then at the other end of the spectrum, there is that which is inspired by fact, but has some creative license, or a lot of creative license. And knowing that, I think that's why it's very interesting to bring this into the context of theater and to let theater talk about what questions have been raised by this controversy, because I don't think you can make a blanket statement that says there's one set of rules for theater and another set of rules for journalism. So, ultimately, I agree in the sense that I think there is theater which purports to take a similar relationship to fact as journalism does, and if it takes that relationship, then it's made a contract and it should stick to that contract. At the same time, I would say, maybe just to give an example from my own work, I've done work where everything in the story is completely true, and at the same time, it would not pass the standards of journalism—because there might be a composite character, there might be something that somebody says that comes out of the voice of the character that's very subjective, and I think I've framed it so the audience is looking at that with a critical eye, but because it's theater, I don't then fact-check it immediately after with another character coming on and saying, you know, "That evidence might not be so." So there's all sorts of nuance, but I agree that you've got to stick to your contract.
Jessica Blank: I think the last point that you just alluded to is particularly important: That one of the standards of journalism is that you're presenting, supposedly, an evenhanded point of view, rather than a subjective opinion and making an argument. And I think, probably, as the person here whose work is the furthest to the journalistic end of the documentary-theater type…The Exonerated is fact-checked—it's first-person accounts, but it's also first-person accounts that are supported by thousand-page court transcripts that we've read, and it's been read by lawyers for libel issues, and we went through all the things you're supposed to do in the making of the play. It still is absolutely in no way a piece of journalism. It's making an argument! It's making an argument through telling a story. And I think that's something different from what journalists do—even if you're using the tools of journalism, and even if you're being really, fully rigorous about the facts.
Steven Cosson: I would throw out, and maybe you guys can help in terms of nomenclature, but there's certainly journalism that makes an argument that might be in the form of a documentary film or a TV show or even a feature article that is intending to persuade, especially if it's an exposé or sort of whistle-blowing article—which I think has to hew even more to the standards of journalism, if you're putting a story out there with a point of view.


text:
Bring Traffic to my dating web site
This project was successfully completed by Gamit for $150 USD in 21 days.Get free quotes for a project like this
Project Budget$30 - $250 USD
Completed In21 days
Total Bids29
Project Description
I have a fairly new web site for dating and I need to generate traffic and get people to sign up to the website. The market targeting is Arabs, Muslims and Arab-Americans.
Completed by:
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
NES Games
Game Questions & Answers (Q&A) service lets you ask questions about video games for game consoles or PC games. So ask your Top Gun question for NES and get answers from real gamers or answer questions and share your insights and experience with the rest of the gaming community.
Boxshot & Details
- Developer: Konami
- Publisher: Konami
- Genre: Simulation Flight
- Release: Not Set
- ESRB: Not Set
Stuck in this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.
Ask a Question
Sponsored Links
Sponsored Links
Trailers & Gameplay Videos
Top Gun - Video Walkthrough
- Added on: May 30, 2014
Top Gun - TAS Speed-Run
- Added on: May 30, 2014
More Options
Games You May Like
The Legends Of Owlia - Gameplay Video
Sunday Funday: The Ride - Gameplay Video
Sky Shark - Commercial Trailer
The Terminator - TAS Speed-Run
Toobin' - TAS Speed-Run
Wai Wai World - Gameplay Video
Sponsored Links
Released Games
- The Legends Of Owlia, (NES)
- Armed For Battle, (NES)
- Battle Kid 2: Mountain Of Torment, (NES)
- Ufouria, (NES)
- Battle Kid: Fortress Of Peril, (NES)
- Bio-Miracle Bokutte Upa, (NES)
- Ninja JaJaMaru-kun, (NES)
- Wario's Woods, (NES)
- Takahashi Meijin No Bouken Jima 4, (NES)
Popular Games
Sponsored Links


text:
× View Today's Deals
You missed it This great deal for El Paso Mexican Grill & Cantina is over. But don't despair, we've got more great deals every day.
Related Deals That You May Like
Vetro 1925
$50 Toward Italian Cuisine
Northwest Arkansas$50$24.99
Bliss Cupcake Café
$10 to Spend on Cupcakes
Northwest Arkansas$10$5
Nutrisystem Dinners My Way® 28-Day Plan
Northwest Arkansas$239$139.99
DNA Self Discovery Starter Map Kit
Northwest Arkansas$89$29.99
El Paso Mexican Grill & Cantina
$10 to Spend on Made-From-Scratch Mexican
- Save 50%
- 207 purchased
deal over
deal over!
94% recommendedin LivingSocial customer ratings
Using the freshest ingredients around, El Paso Mexican Grill & Cantina offers a family-friendly atmosphere and platters of Tex-Mex fusion and authentic Mexican cuisine:
• $5 for $10 to spend on food and drink
• Peruse the extensive menu to find a new favorite meal
• Get the guacamole and it'll be made-to-order at your table
El Paso Mexican Grill & Cantina's Website
PAID VALUE EXPIRES ON February 28, 2022
PROMOTIONAL VALUE EXPIRES ON April 6, 2014


text:
Dean Markley Guitar Strings
Results 1 - 29 of 29 matches
Top RatedDean Markley 2556 Blue Steel Gauge Electric Guitar Strings
Thats right, this is the one everyones been talking about. Its simply amazing what a little -320 liquid...$3.99Compare Compare Now site1prod101052
Top RatedDean Markley 2554 Blue Steel Custom Light Electric Guitar...
Made with -320 degree liquid nitrogen for twice the tone and twice the life. 9-11-16-26-36-46$5.99Compare Compare Now site1prod101054
Best SellerDean Markley 2036 Blue Steel Cryogenic Medium Light...
They're powerful, they're responsive, they're brilliant, and they have tons of punch. Cryogenic processing...$5.99Compare Compare Now site1prod101036
Price DropDean Markley 2552 Blue Steel Light Electric Guitar Strings
Made with -320 liquid nitrogen for twice the tone and twice the life. 9-11-16-24-32-42$3.46Compare Compare Now site1prod101050
Top RatedDean Markley 2032 Blue Steel Cryogenic XL Acoustic Guitar...
They're powerful, they're responsive, they're brilliant, and they have tons of punch. Cryogenic processing...$5.95Compare Compare Now site1prod101030
Top RatedDean Markley 2503 NickelSteel Regular Electric Guitar...
NickelSteel strings are the first electric guitar strings Dean Markley made, and they've been making them the...$4.69Compare Compare Now site1prod101014
Top RatedDean Markley 2555 Blue Steel Heavy Electric Guitar Strings
Great tone and extended life!$5.89Compare Compare Now site1prod101099
Top RatedDean Markley 2562 Blue Steel Cryogenic Medium Electric...
Great tone and extended life!
11-13-20w/18p-30-42-52$4.62Compare Compare Now site1prod101056
Best SellerDean Markley 2034 Blue Steel Cryogenic Light Acoustic...
They're powerful, they're responsive, they're brilliant, and they have tons of punch. Cryogenic processing...$4.08Compare Compare Now site1prod101034
Top RatedDean Markley HELIX HD 2082 Acoustic Guitar Strings - 80/20...
Markley's Hyper-Elliptical Winding process gives a smoother feel as well as a brighter, more resonant tone....$4.21Compare Compare Now site1prod712563
Best SellerDean Markley 2502 Light NickelSteel Electric Guitar Strings
Gauges 09-11-16-24-32-42.

Dean Markley NickelSteel Electic Guitar Strings are mainstays of electric...$3.43Compare Compare Now site1prod101009
Best Seller$9.99Compare Compare Now site1prodJ07981
Top Rated$3.96Compare Compare Now site1prod712567
Top RatedDean Markley 2504 LTHB NickelSteel Electric Guitar Strings
Gauges 10-13-17-30-42-52.
Dean Markley NickelSteel Electic Guitar Strings are mainstays of electric...$2.99Compare Compare Now site1prod101015
Top RatedDean Markley 2505 NickelSteel Electric Guitar Strings...
Gauges 10-13-17-30-42-52.
Dean Markley NickelSteel Electic Guitar Strings are mainstays of electric...$4.99Compare Compare Now site1prod101016
Best Seller$109.99Compare Compare Now site1prodJ04058
Price Drop$5.95Compare Compare Now site1prodJ07977
Best Seller$9.99Compare Compare Now site1prodJ07982
Best Seller$77.04Compare Compare Now site1prodJ04056
Top RatedDean Markley 2038 Blue Steel Cryogenic Medium Acoustic...
They're powerful, they're responsive, they're brilliant, and they have tons of punch. Cryogenic processing...$6.95Compare Compare Now site1prod101038
Best SellerDean Markley 2508 CL NickelSteel Electric Guitar Strings
Gauges 09-11-16-26-36-46.
Dean Markley NickelSteel Electic Guitar Strings are mainstays of electric...$4.69Compare Compare Now site1prod101010
$9.99Compare Compare Now site1prodJ07980
Top RatedDean Markley HELIX HD Electric Guitar Strings (CL)
Gauges: 9-11-16-26-36-46. Made of nickel-plated steel, Dean Markley HELIX HD electric guitar CL strings are...$5.99Compare Compare Now site1prod712566
$3.96Compare Compare Now site1prod712565
$9.99Compare Compare Now site1prodJ07979
Top RatedDean Markley 2557 DT Blue Steel Drop Tune Electric Guitar...
Great tone and extended life!$6.49Compare Compare Now site1prod101084
$6.99Compare Compare Now site1prod712570
$9.99Compare Compare Now site1prodJ07978
$129.99Compare Compare Now site1prodJ04054
When you buy a pack of Dean Markley guitar strings, you can have peace of mind knowing that they've been designed by experts to ensure their high in quality and crafted with a meticulous attention to detail. Whether you're a budding acoustic strummer or a volume-craving metal shredder, you'll have no problem finding the perfect set of guitar strings when you go with Dean Markley.
It's quite amazing what a little liquid nitrogen can do for a guitar string. To see for yourself, check out Dean Markley's 2557 DT Blue Steel Drop Tune electric guitar strings. A highly rated item, these strings have a tone life that's twice as long as regular guitar strings, and will surely impress any player who prefers a drop D tuning style. For acoustic players, the Dean Markley 2002 Vintage Bronze acoustic guitar strings offer a clarity, tone and response unlike any other string of its kind. Durable and easy on the hands, these strings offer everything you'd expect from a name as renowned as Dean Markley.
These days there is an endless array of options to choose from when it comes to guitar strings. But your decision doesn't have to be a difficult one. Dean Markley guitar strings have a shining reputation in the music industry that's constantly growing. So whether you've been playing for years or new to the instrument, you can be sure that Dean Markley has a string to fully suit your playing style.


text:
The ExactTarget Marketing Cloud was not involved in this campaign, but we're happy to bring you examples of great marketing—even when we aren't involved in the execution.
What a difference a few years (and a few new marketing channels) makes. Starbucks, in almost fairy tale fashion, bounced back from competitive and market challenges to reclaim their perky status. Plus, "Starbucks" has recently become synonymous with "awesome marketing." Not only is the beverage behemoth undeniably stronger, but their digital marketing efforts provide one of the best examples of how to leverage a cross-channel approach.
A great example is their Frappuccino Happy Hour promotion from May 1 through 10. A short-lived event lasting just ten days, Starbucks has tapped almost every available channel to help promote a fun, consistent message and a cohesive experience.
And believe me when I say this…they nailed it.
Let's take a look at a sampling of this campaign:
The Standards
First things first, Starbucks updated their website and also released a TV commercial:
Some brands may think that a ten-day campaign doesn't warrant the resources to undertake these channels—and in truth, it all depends on the organization's priorities. Fortunately Starbucks did, and these two updates introduced common imagery (take note of the multi-color diamond animation) that would serve as a motif throughout the other channels.
Intriguing In-App Message
This was actually the first interaction that pushed me down the rabbit hole of the Frappuccino marketing machine. I received the below message in my in-app mailbox:
Not an everyday or even weekly customer, I was immediately interested at what the "summer surprises" could be. But mostly, I loved the text-in keyword "WOOHOO."
Winning Combo of SMS and MMS
Upon texting WOOHOO to Starbucks's short code, I was greeted with promises of Frappuccino fun all summer long.
And this awesome animated gif (that's with a #hardG).
WOOHOO isn't the only keyword out there. Starbucks has cleverly woven several different taglines and ideas into this summer campaign, including SMILE, FLASHY, and SAYYES. I've yet to determine whether any of these differ from the original campaign, as I've received the same welcome message for each keyword, followed by slightly different copy for the cat gif. Starbucks may be using different keywords and taglines to determine where opt-ins are coming from, but I may just be guessing. However, here's a quick recommendation: It's super important to consider the customer's experience when using multiple keywords. No one wants to get the same message twice (or three times). Even if the program is the same across the keywords, change up your copy and images to keep it fresh.
By the time May 1 rolled around, I had practically forgotten about my WOOHOO moment, until this gem appeared on my phone:
This engaging interaction continues with a message cadence of every other day (so far). In an effort to cross-promote their My Starbucks Rewards program, the most recently received message touts an hour extension for members:
Not to mention another in-app message:
Triple Shot of Social, Please
As you may have guessed, Starbucks did not go light on the social presence for this campaign either. What surprised me were the separate identities between "Starbucks" and "Starbucks Frappuccino." The frap has its own Twitter, Facebook, and Tumblr. Both identities are working in tandem to promote #FrappuccinoHappyHour, but luckily not overlapping any content.
(Image courtesy of @Frappuccino)
(Image courtesy of @Starbucks)
(Images courtesy of Starbucks Frappuccino and Starbucks)
(Image courtesy of Frappuccino.com)
And while not as heavy of a promotion tool, Starbucks's Instagram is always easy on the eyes and fun to scroll through. They've made sure to help with cross-promotion efforts.
(Image courtesy of Starbucks)
What We Can Learn
Yes, Starbucks crushes the cross-channel challenge. But what can other (and smaller) brands and organizations learn from this?
- Pick something worthy of promoting cross-channel. While the event only lasts 10 days, Frappuccinos have (apparently) quite the devoted following. And, with summer just around the corner, Starbucks has helped us get into the warm-weather mindset. Will this contribute to increased sales as hotter temperatures arrive? We'll have to wait and see.
- Be consistent across channels. Keep it consistent. Starbucks did a great job utilizing the multi-colored diamond animation in TV ads, MMS messages, and on their website. They also reused images from the Frap's own account instances on many of the corporate accounts. Starbucks also kept the style, message, and voice very relaxed—a very "summer" approach. I mean, they said "pew pew" after all.
- Don't be afraid to operate outside the box. Gone are the days where it was only assumed the serious, black-suited corporate types guzzled down lattes at the speed of the NYSE. Starbucks is recognizing a different audience, and they're taking a different approach. Cats? Playing off Star Wars Day? The photo of an Iron Throne created from pool noodles? Looks like they may be trying to deeply entrench themselves into an almost sub-culture—which is totally different. And totally awesome. Kudos to them!
What are some of your favorite cross-channel wins? Comment below or tweet us @ExactTarget with the hashtag #ETSpark.


text:
Santa's Sleigh Animated Widget
by: Aniwidgets • 1
All Android applications categories
All Android games categories
by: Aniwidgets • 1
Santa's Sleigh animated widget from Aniwidgets is a fully animated widget for your Android phone or Device...
With Animated Widgets from Aniwidgets you can decorate your favorite background with our new exclusive animated widgets.
After placing the widget on your home screen, just simply tap it and the animation will play for 60 seconds. If you want to see the animation again just simply tap it again.
This widget is easy on the battery and only runs for 60 seconds at a time only when you want to see it.
Merry Christmas and a Happy New Year to you all and thank you for looking at Aniwidgets.
Please checkout my other apps and live wallpapers by searching "aniwidgets" on the android market.
Christmas, Santa Claus, snow, winter, Santa Clause, st Nick, Saint Nicholas
Tags: santas sleigh , animated santa claus , animated santa , moving santa claus , animated images santa clause , moving santa animation , stars animation , santa claus animated widgets for blogger , animated santa. claus
Users review
from 1 reviews
Download Santa's Sleigh Animated Widget
Sorry ...
This app is no longer available.
More actions


text: Welcome to Zazzle's Bluebird bag department. Here you will find many styles, colours, and sizes of Bluebird backpacks, handbags, clutches, messenger bags, totes, wristlets and more. Check out all of the great designs featured on our products and choose your favourite. You are sure to find an amazing bag and design that you'll love!


text:
Other 380 Main Street P.O. Box 130 Tofino BC V0R 2Z0 postalHome Phone: 250-726-8235homeWork Fax: 250-266-0412workfaxWork Phone: 1-888-333-5405workPersonal Email: email@example.com: Visit Website
Clayoquot Wilderness Resort & SpaClayoquot Wilderness Resort & Spa
Biographical Info
Outpost Location:
Bedwell Sound
West Coast Vancouver Island
Clayoquot Wilderness Resort offers an ultra-luxurious resort in the remote wilds of Vancouver Island, near Tofino. The Outpost in Bedwell Sound provides 21st-century-safari style lodging in opulently outfitted prospector tents, and a massage and therapeutic treatment centre with the soul of an outpost spa. Activities include whale watching, bear watching, horseback riding, canoeing and kayaking, hiking, mountain biking, hot springs, fishing, and a canopy viewing platform and zip line.
Categories: Accommodation, Bear Viewing Tours, Bedwell River Valley, Canoeing & Kayaking, Clayoquot Sound, Conference Facilities, Dawley Passage Provincial Park, Epper Passage Provincial Park, Fishing Guides, Flores Island Provincial Park, Gibson Marine Provincial Park, Hiking & Backpacking, Horseback Riding, Maquinna Marine Provincial Park, Mountain Biking, Pacific Rim (West Coast), Pacific Rim National Park, Pacific Rim National Park: Fishing, Pacific Rim National Park: Whale Watching, Quait Bay, Recreation, Resorts & Lodges, Rock Climbing, Spas & Health, Strathcona Provincial Park, Strathcona Provincial Park Trails, Tofino, Vancouver Island, Vancouver Island & BC Islands, Weddings & Banquets, Whale Watching, Wildlife Viewing
Updated 1 year ago.


text:
Möchtest du als deine Standardwährung festlegen oder nur für diese Sitzung behalten?
A fresh, clean, unique hotel choice offering comfort, convenience and excellent value.Hotel Karpos is one of the reliable hotels in its segment. It offers competitive rates for both business and leisure travelers.The restaurant features an outdoor terrace. Guests can start their day with a buffet breakfast every morning.A new lodging alternative, hotel Karpos caters to customers who are seeking higher levels of quality and taste. Perfect for a business stay, Leisure, Conference, Celebration.The hotel offers 59 beautifully appointed, spacious guest rooms and suites with excellent in-room amenities and accompanies by highly personalized service.Hotel Karpos is totally different.