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Read an Excerpt
From Brooke Allen's Introduction to Main Street
Main Street is very, very American, but it is not purely American. Shaw, in his characteristically flippant manner, spoke the truth when he said that Lewis's criticisms applied to other nations as well, but that Americans clung to the idea that they were unique in their faults (Literary Digest, December 6, 1930); the British novelist John Galsworthy remarked, truly, that "Every country, of course, has its Main Streets" (Lewis, From Main Street to Stockholm: Letters of Sinclair Lewis, 1919–1930). Still, a disdain for intellect (or for what we nowadays prefer to denigrate as elitism) has been particularly marked in America, perhaps because of our commitment, stated if not practiced, to egalitarian democracy: On Main Street, Lewis writes, "to be 'intellectual' or 'artistic' or, in their own word, to be 'highbrow,' is to be priggish and of dubious virtue."
More than eighty years after Lewis's novel this is true, and it is true not only on Main Street but on Wall Street as well, and on Park Avenue, and on Pennsylvania Avenue. This is what makes Main Street such a stunning achievement: While it succeeds in being "contemporary history," capturing a particular place at a particular moment in time, it also speaks for our own time; it is remarkable how much of Main Street is still pertinent. Gopher Prairie at war is not so very unlike our own flag-waving "war on terrorism." Will Kennicott's breezy dismissal of legal procedure"Whenever it comes right down to a question of defending Americanism and our constitutional rights, it's justifiable to set aside ordinary procedure"can be read on almost any editorial page today. Gopher Prairie's commercial ethos of material "progress" at the expense of every other variety, an idea Lewis would expand and crystallize in Babbitt, has been refined rather than improved in our own era of no-collar workers who meditate or practice yoga before closing the Big Deal rather than smoking cigars and guzzling alcohol.
Lewis, unlike so many of his contemporaries, was never tempted to look for an answer in political dogma: He hated dictatorships and had no particular faith in the virtue or good judgment of "the people." All he really believed in was the wavering, imperfect liberal spirit: "Even if Com[munism] & Fax[cism] or both cover the world, Liberal[ism] must go on, seeming futile, preserving civilization," he wrote in his notes for It Can't Happen Here (quoted in Lingeman).
An atheist with no political illusions, two failed marriages, an unconquerable addiction to alcohol, and a moribund talent might be thought to have had every reason to give up in despair. Lewis, to his undying credit, did not. "It is a completely revelatory American tragedy," he said in his Nobel Prize speech, "that in our land of freedom, men like [Hamlin] Garland, who first blast the roads to freedom, become themselves the most bound." This has been true of many; it was never true of Lewis. Like Carol Kennicott, he was still reachingthough generally failing to graspright up to the end. His particular type of sociological fiction had gone out of fashion at the time of his death, and he continued to be undervalued for decades afterward. But in recent years we have returned to an appreciation for what he accomplished artistically. For what he was able to tell us about American life, in his day and in ours, we can only be grateful.


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Hello neighbor. We're glad you found us. This website is for you to find out what's going on around the Ballinger Neighborhood. See our Calendar page for upcoming meetings and events.
For upcoming events, meetings, City-sponsored activities, visit the NEWS page.
Saturday, August 27, 2016 marks our 8th year of hosting a free community Outdoor Movie Night! Come watch Disney's 1989 family fun adventure HONEY, I SHRUNK THE KIDS. This year we have an even larger movie screen! Activities start at 6:30pm and movie starts at 8:30pm. More details on our 2016 Movie Night page. Event is held at the upper field of Aldercrest park at 2545 NE 200th St, with parking along 25th Ave NE and in the upper parking lot on 200th St.
For past and present activities and projects by Ballinger Neighborhood Association, visit the Activities page.
Do you want to meet new people in your neighborhood? Have a voice in decisions about our community? Want to volunteer? Visit our Volunteer page for information about how you can help.
Many people have contributed hours of volunteer time helping to make the neighborhood a great place to live, play, and work. Organizations have generously donated to the Neighborhood Association's projects. A special thank to those individuals and organizations for their generous support on our Thank You page.

subset: commoncrawl


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Mr Allard held 5 million shares in Owners, the largest director's holding. You may remember that in March Owners turned down an offer from rival Airtours of 150p per share, which valued his stake at pounds 7.5m. At close on Friday, after Thursday's profits warning and resignations, the shares had sunk to 721 2 p. Mr Allard's stake had therefore almost halved in value, to pounds 3.6m. 'Oh, je ne regrette rien. . .'
Owners Abroad may be finding it tough selling its package tours. But it does have one loyal supporter. Ross Jobber, the company's broker at Phillips & Drew, left these shores at the weekend.
We learn from the US that Red Adair, the Texan oil well firefighter, no longer has the risky business to himself. According to the latest issue of Forbes magazine, Adair, who used to work out his fees just by thinking of a number, now faces competition from more than a dozen private and government-sponsored blow-out specialists.
The bulk of the young upstarts got going after the Gulf war, when Saddam Hussein's troops retreated leaving 700 oil wells ablaze. Adair, now 78, has even resorted to advertising in trade magazines. Still, the old warhorse seems unimpressed by his rivals. 'They couldn't find their ass with radar,' he spits.
Westminster Communications, City PR adviser to British Rail and Littlewoods Pools, seems intent on building the biggest group of non-executive directors in Britain. It appointed another four last week, bringing the total to 14.
New on board are three parliamentarians, Menzies Campbell (Lib Dem), Baroness Hooper (Con) and Ann Taylor (Lab). Also picked for the team is Bobby Charlton, the former Manchester United footballer, who is now a director of the club. With five executive directors the agency now has a sizeable squad. 'We're trying to build a full team and a team of reserves,' joked Westminster's Geoffrey Bowden.
A group of Britain's biggest companies got together in London last week to discuss a persistent problem - bullying at work. The workshop, organised by Personal Performance Consultants, said that bullying is a big contributor to stress, low morale and inefficiency in the workplace.
Andrea Adams, a writer and broadcaster who led the discussion, says that in Sweden up to 400 suicides a year are attributed to macho tactics at work.
Britain is not exempt. Last October, it emerged that at one large Scottish company, over 100 people had complained of bullying by the chief executive. One woman was so distraught that, after yet another barracking, she threatened to throw herself down the stairs and had to be restrained by a colleague. In spite of repeated complaints to the company's medical officer the bullying is still going on. 'The problem is that if it goes on, it tends to cascade down the organisation and become almost normal practice,' says Ms Adams.
'Bullies are often insecure people, who cannot cope with stress,' Ms Adams says. Her advice to the bullied is to keep all correspondence and make notes recording verbal attacks. 'The problem is that in this country we tend to believe authority.'
- More about:
- Bobby Charlton
- Consultancy
- Migraine
- Sir Menzies Campbell


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Watch out! Fish
by: oldwang2 • 44
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by: oldwang2 • 44
This is a challenging game and only the best player can keep the fish alive and grow bigger! You have only one chance, use the arrows to control the fish carefully to avoid getting eaten by bigger fish and eat smaller fish. Have fun!
Tags: Free games, Fun games, Free entertainment, Casual games
Tags: fishy game , game where a big fish eats smaller ones , the fish game , fish eat fish and grow game , fishy games , game fish eat other fish grow , fish eat smaller fish get bigger game , game where you eat smaller fish to get bigger , the fishy game
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Business, Business News, News & PoliticsFollow
|Business News
The latest business and finance news from around the world from the BBC
September 19th, 2016
Episode 832 of 969 episodes
Beppe Severgnini of the newspaper Corriere della Sera on the effect of the migrant crisis in Italy. Giri Cherukuri of Oakbrook Investments in Chicago on the day's trading.
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Welcome to the daily audio workout for your head.


text:
Still Blastin'
Credits & Info
- Uploaded
- Aug 12, 2010 | 6:27 AM EDT
- File Info
- Song
- 3 min 34 sec
- Score
- 4.44 / 5.00
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Heard in 10 Entries!
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- Score:
- Rated 4.44 / 5 stars
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- 165,971 Plays | 16,964 Downloads
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- Genres:
- Electronic - Video Game
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Author Comments
Rated 5 / 5 stars
Too good
Yea a song can be too good for its own good , yet this doesn't bring forth a consequence, ( a bad one atleast ) what this gets you sir is , a instant 5/5 and 10 star rating on my behalf. Pieces like this are to be respected and shared with anyone possible , the harmony of sounds can only bring people good like it did to me. As the song progresses so does time , yet it produces a backward motion at the same time producing nostalgia , with this I conclude by saying this song really does bring fond memories of all things good. Keep it up.
Haha! In that case I'd better make songs too good for my own.. good.. some more! <33
Thanks a lot for the kind words, really happy you enjoyed it! <3
Rated 4.5 / 5 stars
Now this is the stuff! Its got a nice intro and energetic. Your obviously not too shy but showing off your stuff so well done my man! My only flaw is that I mean its good but its just err, not sure how to put it, too arcady or you know not that professional. Its not something you would hear in a cd.
Keep up the good work though!
Thanks! I totally get about the CD thing, as it's a 8bit-ish VG mix, they're not supposed to sound very professional I think. As much as I love Megaman, I wouldn't blast the OST out in my car at 90 miles per hour.
... okay that's a lie, I totally did that yesterday
Rated 5 / 5 stars
I usually don't review audio submissions, but this is just amazing. I loved every second of it. This is what makes people want to make music, and what the people who already make music want to make. Perfect ten. Perfect five. Make more.
Wow, those are some really kind words! <3
I can't thank you enough for those!
I shall with the makings of the more! XDDD
Rated 5 / 5 stars
This is entertaining and delicious! I didn't know it was a Megaman mix until I read it in a comment, and wow, it's just... amazing. <3
Thanks a lot for the review!
Now go play some megaman! lol xDD
Rated 5 / 5 stars
it's awesome dude it rock's like mario song
i love it rocksssssss!!!!!!!!!!!!!!!!!!!!!!!!!!
Thank youuuuuuuuuuuuuu!!!!!


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The Executive Rooms offer best in class amenities and come with comfortable twin-beds/double b. The rooms are ideal for business executives arriving or for traveling companions on a trip to the city. Stay at Hotel for a memorable and hassle-free holiday.
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Non AC Room comes with all basic amenities needed for a relaxing stay. The room comes with the choice of a twin bed or a king-size bed. The rooms have an attached bathroom with free toiletries. These Non AC Rooms are large enough to accommodate two adults and 1 infant. These rooms are not air conditioned.
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An investigation of the resolution of inflammation (catabasis) in COPD
- Aina Noguera†1, 2,
- Cristina Gomez†1,
- Rosa Faner†2,
- Borja Cosio1, 2,
- Ana González-Périz3, 4, 5,
- Joan Clària3, 4, 5,
- Angel Carvajal1 and
- Alvar Agustí2, 4, 6, 7Email author
© Noguera et al.; licensee BioMed Central Ltd. 2012
Received: 11 July 2012
Accepted: 6 November 2012
Published: 13 November 2012
Chronic Obstructive Pulmonary Disease (COPD) is characterized by an enhanced inflammatory response to smoking that persists despite quitting. The resolution of inflammation (catabasis) is a complex and highly regulated process where tissue resident macrophages play a key role since they phagocytose apoptotic cells (efferocytosis), preventing their secondary necrosis and the spill-over of their pro-inflammatory cytoplasmic content, and release pro-resolution and tissue repair molecules, such as TGFβ, VEGF and HGF. Because inflammation does not resolve in COPD, we hypothesized that catabasis may be abnormal in these patients.
To explore this hypothesis, we studied lung tissue samples obtained at surgery from 21 COPD patients, 22 smokers with normal spirometry and 13 non-smokers controls. In these samples we used: (1) immunohistochemistry to assess the expression of CD44, CD36, VEGF and TGFβ in lung macrophages; (2) real time PCR to determine HGF, PPARγ, TGFβ, VEGF and MMP-9 gene expression; and, (3) ELISA to quantify lipoxin A4, a lipid mediator of catabasis.
We found that current and former smokers with COPD showed: (1) more inflammation (higher MMP-9 expression); (2) reduced macrophage surface expression of CD44, a key efferocytosis receptor; and, (3) similar levels of TGFβ, VEGF, HGF, PPARγ, and lipoxin A4 than smokers with normal spirometry, despite the presence of inflammation and disease.
These results identify several potential abnormalities of catabasis in patients with COPD.
KeywordsChronic bronchitis Emphysema Inflammation Smoking
Chronic obstructive pulmonary disease (COPD) is characterized by an excessive inflammatory response to inhaled particles and gases, particularly tobacco smoking [1]. Recent studies have shown that this enhanced response persists after quitting smoking [2, 3]. The mechanisms explaining this observation are unknown but unremitting inflammation is likely to contribute to the progression of the disease and may limit the response to anti-inflammatory therapy.
The resolution of inflammation (so-called, "catabasis") is not a passive process that simply occurs when the stimuli that generated it (i.e., smoking) disappears [4, 5]. On the contrary, it is a highly regulated process [4, 5] that requires the coordinated action of specific lipid mediators (lipoxins, protectins and resolvins), pro-resolution and repair proteins (such as tissue growth factor beta (TGF-β), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF)), anti-inflammatory nuclear receptors (such as peroxisome proliferator-activated receptors (PPAR)) and the elimination of apoptotic cells (mostly neutrophils and epithelial cells) by macrophages, a process known as "efferocytosis" [4–6]. Efferocytosis prevents secondary necrosis of apoptotic cells (thus, the liberation of their pro-inflammatory cytoplasmic content) and stimulates the active release by macrophages of TGF-β, VEGF and HGF [4–6]. CD44 and CD36 are surface macrophage receptors involved in efferocytosis [7, 8].
Since inflammation persists in COPD patients despite quitting smoking [2, 3], we hypothesized that catabasis might be abnormal in these patients. To explore this hypothesis, we compared the markers of catabasis discussed above in lung tissue samples obtained from COPD patients, smokers with normal spirometry and never smoker controls.
Study design and ethics
This is a prospective, descriptive and controlled study. Lung tissue samples were collected, processed and provided by the Lung Tissue Biobank of CIBERES (http://www.ciberes.org), as described elsewhere [9]. They were obtained from volunteers that required lung resectional surgery because of clinical reasons, mostly lung cancer. All participants signed their consent to donate these samples for research purposes, and the Ethics Committee of the CIBERES bio-bank approved their use for the current project.
Study subjects
The diagnosis of COPD was established according to the GOLD recommendations [1]. Exclusion criteria included the presence of diffuse pulmonary inflammation or fibrosis, the absence of tumour-free lung tissue specimens, obstruction of central bronchi due to the tumour and/or previous treatment with chemotherapy or radiotherapy. Patients with other chronic inflammatory diseases, alcoholism or receiving systemic anti-inflammatory therapies were also excluded. No patient had an upper respiratory tract infection and/or receive antibiotics perioperatively.
Lung function
Forced spirometry was obtained in all participants according to international guidelines [10]. Reference values were those of a Mediterranean population [11].
Pulmonary tissue sampling and processing
Lung tissue samples were always obtained from non-affected distant areas from the tumour. These samples were either: (1) frozen rapidly in liquid nitrogen, cut into 0.3×0.3×0.3 slices and stored at – 80°C until analysis; or (2) fixed in formalin for immunohistochemistry analysis, as detailed below.
Gene expression
Total lung RNA was obtained from frozen tissue samples with the RNAqueous kit. RNA concentration was assessed in a Nano Drop-1000 spectrophotometer (Nano Drop Technologies Wilmington, DE) and its integrity was tested on a 6000 LabChip in a 2100 Bioanalyzer (Agilent Technologies, Palo Alto, CA). cDNA synthesis from 1 μg of total RNA was performed using the High Capacity cDNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA) in a MJ Research PTC-100 thermal cycler (Bio-Rad, Hercules, CA). Validated and predesigned TaqMan Gene Expression Assays (Applied Biosystems) were used to quantify hepatocyte growth factor (HGF) (ID: Hs00300159_m1), peroxisome proliferator-activated receptor (PPAR) γ (ID: 01115513_m1), transforming growth factor (TGF) β1 (ID: Hs00171257_m1) vascular endothelial growth factor (VEGF) A (ID: Hs00173626_m1) and MMP-9 (ID: Hs00234579_m1) gene expression using β-actin (ID: Hs99999903_m1) as an endogenous control. Briefly, PCR reactions were performed in duplicate using the Universal TaqMan 2× PCR mastermix in a volume of 20 μl containing 1.25 μl cDNA. Quantitative real-time PCR amplifications were performed in an ABI Prism 7900HT Real Time PCR System (Applied Biosytems). Real time PCR results were analyzed with the Sequence Detector Software version 2.1 (Applied Biosystems). Relative quantification of gene expression was performed using the comparative Ct method. The amount of target gene, normalized to β-actin and relative to a calibrator, was determined by the arithmetic equation 2-ΔCt described in the comparative Ct method (User Bulletin #2; http://docs.appliedbiosystems.com/pebiodocs/04303859.pdf).
Lipoxin A4
Frozen lung tissue samples (120 mg) were homogenized in cold DPBS++ with an Ultra-Turrax T 25 Basic homogenizer (IKA-Werke, Staufen, Germany). Two volumes of cold methanol were added to the homogenates and incubated 30 minutes on ice. Homogenates were centrifuged at 2000 rpm for 15 minutes at 4°C and supernatants were collected. Pellets were re-suspended in 1 ml of ethanol and centrifuged again at 2000 rpm for 15 minutes at 4°C. Supernatants were combined and brought to a final volume of 10 ml with distilled water. Samples were acidified to pH 3.5, transferred into syringes and loaded onto activated C18-silica reverse-phase cartridges. The eluted methyl formate fraction was rapidly evaporated under a stream of nitrogen, resuspended in 1 ml of methanol and kept at −80°C until analysis of LXA4 by ELISA (Neogen Corporation, Lansing, MI).
Statistical analysis
Results are presented as mean ± standard deviation, and percentages, as indicated. To compare differences between groups we used nonparametric statistics (Kruskal-Wallis test followed by Mann–Whitney U-test if appropriate). Correlations between variables of interest were explored using the Spearman correlation test. A p value lower than 0.05 (two-tailed) was considered significant.
Characterization of participants
Clinical and lung function data (mean±SD) of all participants
COPD patients
Smokers with normal spirometry
Non smokers
Overall p value
Current smokers
Former smokers
Current smokers
Former smokers
Age, years
64 ± 9
69 ± 10*
55 ± 8+
66 ± 10
62 ± 9
Males, n (%)
10 (100)
10 (91)
8 (73)
9 (82)
3 (23)
Smoking exposure, pack-yr.
64 ± 41
58 ± 22
47 ± 26
64 ± 13
56 ± 12&
54 ± 7&
77 ± 7
77 ± 6
83 ± 4
FEV1, % reference
70 ± 12&
67 ± 11&
97 ± 14
96 ± 19
98 ± 11
Lung tissue gene expression
Pulmonary concentration of Lipoxin A4
Main results show that, compared with controls, COPD patients present: (1) reduced surface expression of CD44, a key macrophage efferocytosis receptor; and, (2) similar lung tissue levels of TGFβ, VEGF, and HGF, despite the presence of more inflammation and tissue damage.
Previous studies
Hodge et al. reported that the ability of alveolar macrophages to ingest apoptotic bronchial epithelial cells and neutrophils (efferocytosis) was reduced in COPD [14, 15]. We did not studied efferocytosis directly, but we found a marked reduction in the surface expression of CD44 in pulmonary macrophages (Figure 2), as other authors and our own group have previously reported in broncho-alveolar lavage fluid macrophages [14, 16] . This was not the case for CD36, also in keeping with previous results [17]. Likewise, we did not find significant differences in HGF, VEGF, TGFβ or PPARγ expression in the lungs of COPD and controls (Figure 3) as others showed before [18–20]. Finally, several lipid molecules, such as lipoxins, protectins and resolvins, are also important mediators of catabasis. Lipoxins reduce neutrophil recruitment and stimulate efferocytosis [21], whereas protectins and resolvins interact with lipoxins to enhance catabasis [22]. Reduced levels of lipoxin A [23, 24] and protectin D1 [25] have been reported in patients with severe asthma [26]. In COPD, results are not consistent and seem to vary according to the specific tissue studied. Vachier et al. found moderately increased levels of lipoxin A4 in sputum of COPD patients [27] whereas Fritscher et al. reported reduced concentrations in exhaled breath condensate of these patients [28]. On the other hand, in peripheral blood, Bozinovski et al. showed that serum amyloid A (SAA) increased disproportionately relative to LXA4 during acute exacerbation of the disease [29]. SAA is a hepatic acute-phase protein that can interact with Lipoxin A4 receptors (ALX/FPR2) and, at variance to Lipoxin A4, stimulate neutrophil recruitment and activation [29]. Interestingly, ALX/FPR2 is also important in the process of apoptotic cell clearance (efferocytosis) [30], a key component of catabasis [4–6]. In our study, in lung tissue homogenates, we did not find significant differences in the concentration of Lipoxin A4 among the five groups of subjects studied here (Figure 5).
Interpretation of findings
A key observation of our study is that patients with COPD show a reduced surface expression of CD44 in lung macrophages (Figure 2). CD44 plays a pivotal role in efferocytosis and, hence, in the regulation of catabasis [8, 31]. This is clearly illustrated in CD44 knock-out mice which, following lung injury, succumb to unremitting inflammation characterized by impaired clearance of apoptotic neutrophils and defective TGFβ release, a phenotype that could be reversed partially by reconstitution with CD44+ cells [31]. Hence, the reduced surface expression of CD44 in lung macrophages of COPD observed in our study (Figure 2) has the potential to favour secondary necrosis of apoptotic cells (known to be increased in COPD [32, 33]) and to prevent an adequate pro-resolution response (enhanced TGFβ, VEGF, and HGF macrophage release). We propose that the absence of significant differences between COPD patients and controls in either protein (Figure 3) or lipid (Figure 4) mediators of catabasis actually supports a blunted catabatic response in COPD because the presence of chronic inflammation and lung tissue damage should enhance it [34]. We accept that this is a hypothesis that will have to be confirmed or refuted in future studies but, in keeping with this proposal, our group previously showed that alveolar macrophages of COPD patients release less TGFβ than controls when stimulated in vitro with LPS [35]. This also suggests a defective response to a well-characterized pro-inflammatory stimulus. We hypothesized that all these mechanisms can contribute to the enhanced and persistent inflammation (higher MMP-9) that characterizes COPD and to defective tissue repair. Further, a self-sustained loop can develop because MMP-9 is known to participate in the shedding of CD44 [36], although we did not find a significant relationship between MMP-9 expression and % CD44 positive macrophages in our patients (Figure 4, Additional file 1: Table S1 on-line supplement), and the absence of VEGF stimulation causes lung cell apoptosis [37]. The iteration of this loop can contribute, in combination with the absence of a significant up-regulation of PPARγ or lipoxin A4, to the presence of unremitting inflammation in COPD and disease progression, even after quitting smoking. These potential mechanisms deserve further research.
Not all smokers develop COPD. Our results show that CD44 surface expression in macrophage is only reduced in those with COPD. Why is this the case cannot be answered from our study and also requires further research. However, potential mechanisms may include one or more of the following, among others. Susceptible smokers with COPD are likely to have a genetic background that favours an enhanced inflammatory response [38], and this may initiate the process by shedding macrophage CD44 [36], hence limiting the efficiency of efferocytosis [7, 8]. Alternatively, there may be individual differences in the expression of CD44 [39], making smokers with low constitutive CD44 expression more susceptible to the development of COPD since, as discussed above, CD44-deficient mice succumb to unremitting inflammation after lung injury with impaired clearance of apoptotic neutrophils and impaired activation of TGFβ [31]. It is also possible that efferocytosis of apoptotic cells may be overloaded (hence secondary necrosis allowed) if the number of apoptotic cells increases significantly, as it seems to be the case in COPD [32, 33]. And, of course, none of these mechanisms is mutually exclusive, so a combination of them may also occur.
Strengths and limitations
The fact that we studied lung tissue macrophages is at variance with previous studies investigating broncho-alveolar lavage samples and is a clear strength of our study. However, we acknowledge that our study has limitations that deserve comment. First, its descriptive nature does not allow us to make firm mechanistic inferences. Second, we did not study the expression of LXA4 receptor (ALX/FPR2) which, according to recent publications, may play an important role in the regulation of catabasis [29, 30]. Third, lung tissue samples were obtained at surgery from patients suffering from cancer. Despite that samples were always obtained from non-affected distant areas from the tumour and that no patient had received radio- or chemo-therapy before surgery, we cannot exclude an influence of the tumour itself on the results of our study. However, both COPD and controls had cancer, so any eventual influence of the tumour should have influence results in both groups. Besides, this is a limitation of basically any study using human lung tissue samples. Finally, we acknowledge the relatively small sample size of our study and the fact that, due to the origin of the tissue samples, we could not study patients with more severe airflow limitation.
The results of this study support the hypothesis that catabasis might be abnormal in COPD. If so, this may be a key mechanism explaining the persistence of inflammation in these patients, even after quitting smoking, and, potentially, the progression of the disease. The confirmation of this hypothesis requires further research.
Chronic obstructive pulmonary disease
- TGF-β:
Tissue growth factor beta
Vascular endothelial growth factor
And hepatocyte growth factor
- PPARγ:
Peroxisome proliferator-activated receptor gamma
Matrix metalloprotease 9
Polymerase chain reaction
Enzyme linked immunosorbent assay
Lipoxin A4
Dulbecco's phosphate buffered saline
Serum amyloid A.
Authors thank Meritxell Arqué and Cristina Villena (CIBERES biobank) for their support in providing lung tissue specimens for analysis.
Supported, in part, by FIS 09/00629, FIS 10/00523 and an unrestricted grant from GSK.
Authors' Affiliations
- Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, et al: Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary. Am J Respir Crit Care Med. 2012, 10.1164/rccm.201204-0596PP.Google Scholar
- Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, et al: The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004, 350: 2645-2653. 10.1056/NEJMoa032158.PubMedView ArticleGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Safe Online Payments
|Bus Operator
|Last Bus
|Kalpana Travels Pvt. Ltd.
Jaipur to Shivganj Bus Service
|Number of buses :
|Starting Fare :
Jaipur to Shivganj Bus Distance
|Time taken :
|17 hours 20 mins
|Total operators :
Long journey by bus from jaipur to shivganj is made effortless by redBus, one of the eminent bus ticketing platform fulfilling most of the travel requirements. Numerous operators run their buses in this route creating ample amount of convenience for many people in India. Secured online ticket reservation process and easy booking techniques help every traveler to undergo smooth booking.
If you are also looking for return checkout, please ensure to checkShivganj to Jaipur Bus Tickets.
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It was a good experience. Staff's behaviour was quiet good. But the bus was not spacious.
Bus departed 45 minutes late from its scheduled departure from source station. Seats were so so dirty and were smelling very badly. They just care of money but not facilities. Overall it was a bae experience.
Jaipur is byfar the most popular tourist destinations of India and forms the 'Golden Triangle' of Indian Tourism Industry together with Delhi and Jaipur. The city of Jaipur having a rich royal background charms in tourists from all corners of the world. Tourists throng to the city in large numbers to soak in the grandeur, rich culture and heritage of the region. There is plenty to see and do in the city. Some of the major sightseeing attractions of the city include the Amber Fort, Jaigarh Fort, City Palace, Jal Mahal, Jantar Mantar and Hawal Mahal among others.


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Hello All,
Of the exchange of recent messages two have been sent in
Rich Text (HTML) and another with MIME turned on.
Please note that all messages should be sent to the group
in Plain Text and with MIME turned off. (Refer to you
browser help files if you don't know how). I am relaying
the regulation given by St John's for the use of their listserv
software and facilities that have allowed this group to
continue. Although some messages not complying with
these criteria do often get through they may not always
do so, and in at least some of our mailboxes it shows
up with all the HTML code almost hiding the actual
If they group as a whole wants the ability to use HTML in
sending messages then we would need to consider a new
host. In the past when this has been floated all those that
responded were in favour of use remaining as we are.
The group has the use of webspace, under it's own web
address (www.igsrobin.info), for posting any photographs etc
(This is not the IGS society website which is at
www.geocities.com/RainForest/2822 ).
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email discussion group on pelargoniums, geraniums & all Geraniaceae
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SUBSCRIBE IGSROBIN Your Name


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Abt Card
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Average Customer Reviews
Features a matte black finish for low-profile shooting. Waterproof to 131'/40m.
The Blackout Housing keeps a low profile thanks to its matte black finish. It's perfect for special ops filming with your GoPro, and capturing footage without drawing attention to the camera. The included LCD concealment stickers help eliminate light reflection from the housing's LCD window. Waterproof to 131'/40m. Includes Standard and Skeleton Backdoors.
What's Included:
Approximate Weight:
(based on 1 review)
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Reviewed by 1 customer
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By Warren
from chicago, il
About Me Athlete, Traveler
Best Uses
Comments about GoPro Camera Blackout Housing:
Great case. Easier to open than previous models.
Bottom Line Yes, I would recommend this to a friend
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Spontaneass 2 [WEBRip 720p] (2014/EvilAngel/4.81GB)
Here you will find fresh porn videos, movies for every taste. You can download their by clicking on the link site file-sharing service Nitroflare, Uploaded, Gigapeta, Keep2Share.cc and many other.
There's a private party going on, with busty Asian babe London Keyes, athletic cutie Lea Lexis, little redhead Penny Pax and freckled, big-assed beauty Jodi Taylor. These perverted young lesbians love wild, spontaneous sex -- eating one another's sweet pussy and asshole, worshiping pretty bare feet and masturbating with all sorts of toys, including long ass-to-ass dildos, large, sphincter-expanding anal balls, and things that really wreck buttholes! Their nasty foursome ends in a flurry of tongue kissing.
At an intimate gathering of stunning lesbian porn idols -- exotic Gabriella Paltrova, tattooed black seductress Skin Diamond, gorgeous Sarah Shevon and brunette hardbody Dana DeArmond -- the talk inevitably turns to buttholes. Gabriella needs some anal attention, so Skin helpfully inserts her digits inside her friend's big booty. Everyone joins in, probing Gaby's pussy and asshole, and before long the girls are in a spit-soaked orgy of rim jobs, toe fucking and four-finger ass jamming, using toys and a vibrating wand to make each other climax.
Original Name: Spontaneass 2
Production year: 2014
Studio: Evil Angel
Genre: Anal, Asian, Ass, Big Tits, Brunette, Bubble Butt, College, Cunilingus, Ebony
Starring: Dana DeArmond, Gabriella Paltrova, Jodi Taylor, Lea Lexis, London Keyes, Penny Pax, Sarah Shevon, Skin Diamond
Duration: 02:17:16
Quality: WEBRip/HD
Format: MP4
Video: AVC 1280x720 (1.778) 4 800 Kbps
Audio: AAC LC at 152 Kbps
Size: 4.81 GB
Users of Guests are not allowed to comment this publication.


text:
Bass Brush Detangler
This detangler brush is designed to gently ease out knotsfrom the coat without damaging hair fibres. It can be used with wet or dry hairand is made with nylon bristles for easy cleaning.
Bass have manufactured premium, high quality pet brushes forover 30 years. All Bass brushes are made from natural bamboo, an incrediblysustainable and environmentally friendly material. Each innovative Bass productis constructed to create durable, effective, professional, and luxurious doggrooming brushes.
Bass Brush Detangler Features:
Groomers Expert Tips: For use on tangles and knots, forsevere matting use a de-matting tool.
Please see our full Pin Brush range.
Groomers offer FREE DELIVERY on all UK orders that exceed £100 and contain light goods items.
• Orders over £100 LIGHT GOODS: Free, same day despatch (Monday - Friday).
• Orders over £100 HEAVY GOODS: Freight charges apply - typically £45 per pallet, 5 - 10 working days approx (Monday - Friday).
Heavy goods include most tables, baths and drying cabinets.
Delivery Charges Light Items (for mainland UK only - please contact us for destinations outside mainland UK)
• Up to 0.25Kg = £3.30
• Up to 0.5Kg = £3.65
• Up to 0.75Kg = £3.95
• Up to 1kg = £4.40
• Over 1Kg = £6.70
Express Delivery Light Items
• Up to 1Kg = £5.49
• Over 1Kg = £6.87
Non-mainland UK, including Scottish Highlands, Northern Ireland and offshore islands may be subject to a surcharge.
Please email us for an overseas shipping quote - firstname.lastname@example.com.
Online, mail and telephone order customers have the right to cancel their order for a limited time even if the goods aren't faulty. We will offer a refund to customers if you have notified us in writing within 14 days of receipt that you wish to cancel. Cancelled goods must be returned to Groomers Limited within a further 14 days after we have been notified. We will refund customers within 14 days of receiving the goods back.
No reason for return is required.
Please note that you will be responsible for the cost of returning the goods to us unless we delivered the item to you in error or the item is faulty. Your unwanted item must be in a resaleable condition and in the original, undamaged, unopened product packaging with any labels still attached.
Please remember the packaging of the item is the responsibility of the sender, not the courier, and Groomers Limited reserve the right to apply a 10% return to stock handling charge if an item is received unsuitable for re-sale.
To find out more, please see our shipping and returns page.
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A 'questionnaire' system that goes just that little bit further.... This was the first publicly available online system by Roestenburg.RDD.
A java based application for playing correspondance chess. Your moves will be sent in the format specified by the IECC. It will not calculate any moves for you, but it will let you know which opening you're playing (if known to the application).
You're welcome to a free copy at request.
A Windows desktop application (yes they still exist) for merging audiobook CDs into 1 single CD. Rip your CDs with applications/systems like MediaPlayer, and drag them all into AudioMerge. Out will come 1 folder with all tracks neatly renamed and their properties amended, nicely ordered. You can then burn it to a CD with your favorite burning program. This makes it easier to listen to stories in the car.
Created for private use, but you're welcome to a free copy at request.
Our combined work as a private business, as well as under regular employment, comprises of many applications in various industries. This ranges from banking and insurences to telecoms and manufacturing, in the Netherlands, England/Britain and the United States.
A small collection of our work follows.
CAD system for designing cables (fiber, high-voltage, earth, aerial) and calculating their properties.
Spatial calculations (research + development) to enhance the basic libraries of Kinect version 2.
An intranet application for administering budget information and planning for subsequent years.
Internet application for companies to apply for recuded working hours in case of calamities.
A framework for providing personalisation internet wide. One account for the whole internet.
Distributed Excel application for managing personal development related information
Distributed Excel application for managing performance related information
HR related tabular data and graphs, pulling data from mulitple systems
Building and maintaining contracts from small building blocks.
All communication channels converged into one.
A platform for an integrated view of multiple security cameras.
This includes selectors and dashboard facilities.
Automation tool for System Administrators.


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Peninsula Lamb Shanks
|Lamb shanks
|1 Pound (About 6 Pieces)
|1 1⁄2 Teaspoon
|1⁄4 Teaspoon
|3 Tablespoon
|3 Tablespoon
|Canned chicken broth
|14 Ounce
|1 Medium, sliced
|1 Clove (5 gm), finely minced
|Sliced celery
|4 Cup (64 tbs)
|3 Medium, cut into wedges
|Chopped parsley
|1 Tablespoon
Sprinkle lamb with salt and pepper.
Heat oil in Dutch oven.
Add lamb; brown well on all sides.
Remove lamb; set aside.
Stir flour into oil; brown lightly.
Gradually blend in broth and 1 3/4 cups water; bring to boil.
Return lamb to Dutch oven; add onion and garlic.
Reduce heat; cover.
Simmer 1 1/4 to 1 1/2 hours, until lamb is tender; remove lamb to warm serving platter.
Add celery to liquid in Dutch oven; cook 10 minutes.
Add tomatoes and parsley; cook 5 minutes.
Spoon over lamb.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 1776 Calories from Fat 992
% Daily Value*
Total Fat 111 g170.7%
Saturated Fat 33.4 g166.8%
Trans Fat 0 g
Cholesterol 303.9 mg101.3%
Sodium 3716.3 mg154.8%
Total Carbohydrates 92 g30.7%
Dietary Fiber 17.5 g69.9%
Sugars 28.1 g
Protein 106 g213%
Vitamin A 129.9% Vitamin C 164.2%
Calcium 36.7% Iron 78.4%
*Based on a 2000 Calorie diet


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The first time I heard about protein pancakes was from a Facebook friend. When she told me what was in them, I all but gagged. I just could not fathom the idea that these might actually be edible.
A few weeks later, I was watching some videos on BodyBuilding.com of Ava Cowan (fitness model). I'm a big fan of hers, and was curious to see how she eats and works out. Imagine my surprise when she demonstrated how to make protein pancakes!
So I figured if my friend on Facebook and Ave Cowan can eat these, then there must be something to them other than just a high protein breakfast. So I gave it a shot.
I can tell you that not only were my husband and son impressed (guys and kids are the toughest critics!), but I was just over the moon. I've been eating these puppies for breakfast every morning since and I haven't gagged even once! I swear! They are almost like eating a savory oatmeal muffin. A bit on the fluffy side, and just downright delicious!
From the Gracious Pantry archives. Originally posted: 2/18/2011
Clean Eating Protein Pancakes
(Makes about 7 pancakes)
Adapted from BodyBuilding.com
- 12 egg whites
- 1 cup quick oats
- 1/2 teaspoon olive oil (from an oil sprayer)
Ooey-Gooey Toppings:
- 1 tablespoon clean peanut butter
Extra Fiber Toppings:
- 1 tablespoon clean hummus
Savory Mix-In Seasonings:
- 1/2 teaspoon onion powder
- 1/2 teaspoon garlic powder
Sweet Mix-In Seasonings:
- 1 teaspoon. cinnamon
- Top with maple syrup
- Stir both ingredients together in a mixing bowl.
- Spray a non-stick pan (yes, it has to be non-stick) with about 1/4 tsp. olive oil. It's not much at all. Just a very light mist.
- Ladle 3 pancakes onto your pan and cook like a regular pancake. Each pancake should be approximately 1 scant ladle full. Depending on the size of your ladle, you should get about 7 pancakes out of it.
- Spray with the last half of the oil, and ladle on your last 3 pancakes.
- You can serve this with any clean toppings you like. But I prefer to eat them plain like a piece of toast. Once they've cooled down, you can just grab and go!


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Does this activity require advanced planning, ticketing or reservations?
Is this activity accessible without advanced planning or reservations?
Is this attraction free to the public?
Is gratuity suggested at this attraction?
Would this be a good rainy day activity?
Is there food available at this attraction?
Is a car required to access this attraction?
Is this attraction accessible using public transportation?
Is this attraction closed during certain parts of the year?
Is this attraction wheelchair accessible?
Thanks for helping!
Very family friendly, affordable, clean/comfortable. Great movie selections for everyone. Excellent staff that gives fantastic customer service.
I have lived in Taos for just about 5 years and still here. I am a movie "BUFF" to the fullest so any small town or city I am in there HAS to be A Movie theater, so when I have first gone to Storyteller 7 I wasn't to impressed yet I was grateful to be able to go at...
Small but very nice theater. It's very clean - seating is wonderful, staff is wonderful, prices are very reasonable for entry and for snacks. It was well worth going.
I never knew that there was a cinema in Taos, but it was my daughters birthday and she wanted to see Cinderella. I was pleasantly surprise at how nice the theater was, and the staff was very friendly. One reason I am not a fan of movie theaters is the price of the snacks is usually ridiculous, but at this...
Finally, the Storyteller Cinema 7 in Taos is a nice theatre. The place has been renovated and is much more attractive upon entering. It is nice and bright and the concessions have been remodeled as well. The seats in the theatre are comfortable. They rock and have holders for your beverages. We found the theatre clean and pleasant. Be sure...
I always wish they omitted coarse language from movies but I loved the music. The 4 seasons were favorites of mine.
Great place to catch first-run movies. This theater is always very clean and the staff is friendly. The ticket prices are about as cheap as it gets for a theater, and the concession prices and the best you will find anywhere.
We see a movie here every time we're in the area, and it's always a good experience.
Highly recommend.
I took my grand-daughter to see Monster University and after paying we went to hand our ticket to another employee. He said, "I need to search your purse". I said "excuse me, WHY?" He never answered except to say "I need to search your purse". So I opened my purse!!! Then 8 feet before our entrance to the movie another...
New ownership has lowered movie prices - a very welcome thing in this economy! Nice theater. Friendly staff.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


text:
Fair Hotel. Service is poor.
Guest Review Highlights
- Service is poor
Wego searches multiple travel sites so you can find and compare the best rates.
Based on 26 reviews from across the web.
Fair Hotel. Service is poor.
Check-in: 13:00
Check-out: 10:00
Hotel Rio Diamante is a perfect starting point for exploring the attractions of San Rafael and the area, including Plaza San Martin, which is just steps from the property. The hotel offers wireless Internet access, breakfast, a comfortable lobby, and tourist information in the reception. Take advantage of affordable rates, and make your booking now for your next business trip or vacation to San Rafael.


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"Adams Puglielli Wedge The CNC fly-cut face on the Adams Puglielli Wedge has been precisely milled for more consistent spin and the carbon steel finish provides optimal feel. The 7-gram weight cartridge reduces vibrations for a soft, responsive feel and allows for swing weight adjustments. Max Puglielli an Adams Golf industry veteran developed this wedge for the better amateur player. It's designed with a classic teardrop shape and comes with tour proven performance. ""Players want consistency and control with their wedges and these new wedges deliver those results and more. Great spin control with the milled groove configuration, tremendous feel and a classic look and shape that better players appreciate."" Features - Adams Pugielli Wedge • Brushed Satin Finish • CNC fly-cut face with milled grooves. • Vibration-dampening system for better feel. • 8620 carbon steel with mirror-plated finish. • Six models available. • True Temper Dynamic Gold Steel Shaft. Specs Loft Lie Length Swing Weight Hand Bounce 52 Deg 64 Deg 35.5 in. D4 R 10 Deg 52 Deg 64 Deg 35.5 in. D4 R 12 Deg 56 Deg 64 Deg 35.25 in. D4 R 10 Deg 56 Deg 64 Deg 35.25 in. D4 R 14 Deg 60 Deg 64 Deg 35 in. D4 R 6 Deg 60 Deg 64 Deg 35 in. D4 R 8 Deg"
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Description from the owner
Description from the owner
Bedrooms: 6/
Bathrooms: 3/
Sleeps: 15/
Type: House
Book this 6 bedroom, 3 bathroom house in Tannersville today! A total of 15 people can sleep here comfortably.
Guests can enjoy a pool, deck, and outdoor grill among other amenities offered by this rental.
No travelers have shared a review of this property yet.
Costs vary, with the average weekly rate as low as $2,293.00 to as high as $4,293.00, depending on travel dates.
The owner last updated the property's calendar 2 years ago, so this rental may not be available for your requested dates, but please inquire to confirm.
Proximity to TripAdvisor's Top Tannersville Attractions
Proximity to TripAdvisor's Top Tannersville Attractions
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Getting a microdermabrasion can take 10 years off your face, just as marrying the district attorney can take 10 years off your sentence. Shave off some time with this Groupon.
The Deal
- $40 for an express diamond microdermabrasion (an $80 value)
An express diamond-tipped microdermabrasion treatment diminishes the appearance of fine lines, scars, and sun damage.
Alternatives: A Center for Conscious Health
While Dr. Patricia Ryan, who is board certified in both Family Practice and Anti-aging medicine, was busy with her family practice, she began to notice a problem. A portion of her patients' discomfort could not be helped with medication, surgery, or physical therapy. So she began to take a more multidisciplinary approach. After discovering the root cause of her clients' ailments, Dr. Ryan and her team perform services such as anti-aging and hormone replacement, nutritional consultation and support, and IV therapy. Esthetic services include botox, microneedling, facials, peels, and microdermabrasions.


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Ever wonder what Johann Sebastian Bach would sound like with a little '70s gloss on top? Good, actually. It sounds damn good. Read More »
Home / Tag Archives: johann sebastian bach
Music Review: Fretwork – Bach: Goldberg Variations
Fretwork have delivered a magnificent edition of Bach's Goldberg Variations. Read More »
Music Review: András Schiff and Johann Sebastien Bach – Six Partitas
Schiff's performance is accessible, poignant and succint. Read More »


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LEau dIssey reveals the pure scent of water. Its sparkling fragrance, with its floral, fresh and woody notes, embodies timelessness and movement.
Thank you for visiting Leau dissey edt 50ml spray on happybeauty.co.uk
We bring the products from many websites to one website for you to search, save and compare.


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Online Programs
Become part of the most supportive educational community online.
When you spend most or even part of your time in the professional world, it's hard to find time to further your education, and even harder to find a quality program with faculty and staff who are dedicated to helping you succeed. Quinnipiac University's online programs – a full suite of undergraduate, graduate and doctoral degrees and certificate programs – are designed to do exactly that. Access to our full-time faculty and the resources you need to go further in your career – and in life – are what set our online programs apart from others.
Online Undergraduate Programs
School of Business
Bachelor of Business Administration
With well-educated managers in high demand, Quinnipiac's online bachelor of business administration offers those holding an associate's degree or a minimum of 60 transferrable credits, an ideal pathway for career advancement. This program, led by industry experienced faculty, prepares graduates with the career-ready business skills that employers are looking for.
School of Health Sciences
Bachelor of Science in Health Science Studies
For those with an associate's degree or 60 credits in science, the BS in health science studies allows students to complete a degree and be prepared for either graduate level work or career advancement in the field of health science. This program is also designed to help those interested in making a complete career change to health sciences from an unrelated field.
School of Nursing
Bachelor of Science in Nursing (RN to BSN)
With health care evolving every day and an increasing demand for nurses with bachelor's degrees, our online RN to BSN program gives you the tools and expertise you need to evolve with it. Learn from knowledgeable faculty members who apply years of real-world applications to each lesson to create a richer learning experience.
Online Graduate Programs
School of Business
Master of Business Administration
The business world is changing at an unprecedented pace. Our acclaimed, 46-credit MBA degree program prepares you to lead in this dynamic field by combining fundamental theories with invaluable interpersonal and professional skills. MBA students have the option of choosing a Chartered Financial Analyst® track, health care management track, or supply chain management track for a more focused experience.
Master of Science in Business Analytics
Big data becomes more manageable with this specialized, 33-credit program, designed for students and professionals who seek leadership positions that require a deep understanding of sophisticated analytics. In today's evolving business world, mastery of these quantitative skills – and the ability to apply them to the most difficult challenges – is in high demand.
Master of Science in Organizational Leadership
The word "leader" is freely tossed around, but there are few people who rise to the challenge and become true, effective leaders in their organizations. Our graduate-level organizational leadership program places an emphasis on the self-awareness and understanding of others necessary to become a good leader, and then focuses on ethics, communication and strategic thinking and analysis. Students in this program may choose one of four professional focus tracks: health care management, human resource leadership, public service/nonprofit leadership, or strategic leadership.
School of Communications
Master of Science in Interactive Media
In the digital world, change occurs at an extraordinary pace, more than in any other industry. The MS in interactive media helps professionals prepare for those changes by creating innovative thinkers and teaching emerging technological skills that students can immediately implement on the job. Students have the option to pursue a multimedia production concentration, social media concentration, user experience design concentration or their own custom concentration.
School of Education
Master of Science in Instructional Design
With so many new digital tools, materials for learning can be more effective than ever. Our master's program in instructional design gives you the opportunity to make a real impact on the learning process – in schools, universities, other nonprofit organizations, or business settings– by teaching you how to apply what we know about how people learn to the design of educational materials using cutting-edge technology. Students may customize their own program or choose one of the following specializations: design and development of online learning, technology for the K-12 classroom or instructional design for corporate or nonprofit environments.
Master of Science in Special Education
There is a growing demand for educators and professionals who possess the necessary skill set to foster an inclusive learning environment and help all students succeed. The 30-credit MS in Special Education provides graduates with a deeper understanding of the laws governing special education and the skills to create a safe and effective learning environment. Current teachers may elect to seek a cross-endorsement in special education, but students are not required to be teachers to earn the degree.
Master of Science in Teacher Leadership
The MS in teacher leadership program is ideal for teachers who are ready to evolve into leaders. The program prepares teacher leaders by focusing on the skills necessary to positively transform school culture, embrace diversity in the classroom, and improve both school and student outcomes. Objectives of the program are aligned with the standards of the Educational Leadership Constituent Council. Students in this program may choose one of three areas of specialization: literacy leadership, mathematics leadership or program improvement leadership.
School of Nursing
Master of Science in Nursing in Operational Leadership
As health care continues to evolve, expectations for nurses go far beyond patient care. The 32-credit MS in nursing in operational leadership may be completed entirely online and prepares practicing nurses with advanced skills in organizational dynamics, patient safety and leadership to fill the need for dynamic professionals at the point of care – all while embracing the culture of compassion that the profession embodies.
Online Doctoral Programs
School of Health Sciences
Occupational Therapy Doctorate
Designed for practicing registered occupational therapists who want to merge their experience and practical skills with prevailing professional knowledge and scholarship, the occupational therapy doctorate prepares you for a leadership role without interrupting your career. This clinically-focused program allows you to become an agent of change within your community and advance your career, the field of occupational therapy and the lives of your patients. Students with a bachelor's degree may apply for our BS to OTD bridge program.
School of Nursing
Post-Master's Doctor of Nursing Practice (DNP)
The post-master's doctor of nursing practice (DNP) prepares graduates to take a more active role in improving the quality of care for patients, managing effective use of resources, inter-professional collaboration, disease prevention efforts and ethically-based care. Students may choose from three specialized tracks: care of populations, nurse anesthesia or nursing leadership.
Post-Master's Doctor of Nursing Practice (DNP) - Nurse Anesthesia Track
The nurse anesthesia track is designed to help practicing nurse anesthetists to advance into leadership positions in clinical practice through a well-balanced DNP curriculum. Students in this program will explore topics ranging from human factors and patient safety to health care leadership, and will be well-prepared to excel in the competitive field of nursing upon graduation.
Online Certificate Programs
School of Business and School of Law
Health Care Compliance Certificate
The School of Business and School of Law jointly offer this highly specialized certificate program that is designed to meet the high demand for health care managers and attorneys who are knowledgeable about compliance with federal and state regulations. Quinnipiac University is certified by the Health Care Compliance Association (HCCA) to offer the first university-based program in the country to train health care compliance officers.
School of Communications
Graduate Certificate in Social Media
This online certificate program is ideal for both professionals who need social media skills to go further in their jobs and those who have taken over as the leaders of their company's social media functions. Students can gain a full foundational understanding of social media as well as tools that they can take back to the workplace and use immediately to help their organizations thrive.
School of Education
Special Education Certificate of Completion
Children are being diagnosed with special needs at younger ages than in the past. As a result, there is a growing demand for classroom teachers at all levels to have training in special education. This online certificate program arms teachers of inclusive classrooms with strategies for differentiation, collaboration and accommodation that will both help you in the classroom and give you a competitive edge in the job market.


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Claws of life gripping and ripping
Gnawing at my life force
Fading from sight
Fading light
Darkness invades
Single flicker
Glow from above
An immortal stood before me
Caught in his trance I followed
I see daylight with you
Behind me is the blood and the pain
You rescued me
Brought me to life again
Intense and pure is the love I feel
I no longer exist
I live
I love
I feel
The beauty in life
The beauty in you
© Copyright 2017 naye. All rights reserved.
Status: Finished
Genre: Romance
I love this and I can really relate to your situation. Darn good for a 5 minute poem.
Poem / Poetry
Book / Young Adult
Poem / Poetry
Shelves: 7
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text: Keokuk Meth Arrest; 10 Years in Prison August 1, 2014 Local News | News Team The Lee County Narcotics Task force arrested 26-year-old Morgan Burns of Keokuk yesterday on felony drug charges. Burns has been charged with with Delivery of Marijuana. If convicted, Burns faces up to 10 years in prison.


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With Windstar's Star Perks event, choose your free perk from a list of four great amenities including up to 2 free hotel nights, premium beverage package, unlimited WI-FI or up to $1,000 shipboard credit.
Windstar is proud to unveil our 2018 winter voyage collection featuring 15 new voyages and 40 new ports. Book now for reduced fares + free perk!
For a limited time, book your luxury Tahiti cruise with Windstar and enjoy air from Los Angeles (LAX), 1 night pre-cruise accommodation at the Le Méridien Hotel in Papeete, transfers from the airport to the hotel and yacht, plus a day room at the Le Méridien Hotel in Papeete post-cruise.
We'll send you the latest deals to your email.
Click here to view our current special offers.


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VIDEO: Inhabitat Interviews MoMA Curator Paola Antonelli About 'Talk to Me'
Inhabitat: It seems in some way that this exhibit is sort of showcasing how design is moving away from designing objects and moving more and more into designing experiences. What kind of impact do you think this has on the world we live in and the element of sustainability?
Paola Antonelli: We have been living in more than one world for quite a while. Design has not been only our furniture or our cars, but also it's been the interfaces of the websites that we live in, the interface of our email program. What's happening right now is that the virtual world is only one of the possible extensions of traditional design. A formal design that is relatively new – it's old but new – is critical design. Critical design is about commenting on the possible consequences of technology, even dystopian ones. And there's a lot of examples of that in the exhibition because since these designers focus on crucial issues, they also focus a lot on communication.
All in all, I think that what we're seeing today is designers becoming much more economical and sustainable – also about their own careers. It's not possible anymore to build objects that people will throw away in just a short amount of time, because people think that one of the possible ways to be sustainable is to have a washing machine that lasts 15 years instead of three. So that's one way to go. What happens there is that it means fewer appliances and fewer design opportunities for traditional forms of design. But there's a whole world that is on the web. It's a whole world that is about behaviors. There's a whole world that is about interactions. There is this amazing infiltration of design in all the facets of our lives that goes well beyond the traditional furniture products and cars. I'm so happy about it because, as you've said, this is truly the moment to not only study, but also validate this form of design and give it some benchmarks by doing collective shows like this.
Video by Phelps Harmon
Related Posts
- 'Born Out of Necessity' at MoMA Seeks Solutions for Pressing Problem Through Innovative Design
- PHOTOS: 7 Great Green Gadgets Seen at Engadget Expand NY
- Brooklyn Atlantis Underwater Robot Will Probe the Polluted Gowanus Canal
- Talk To Me Exhibit at MoMA Examines Communication Between People & Objects
- Innovative Designs in MoMA's Talk to Me Exhibit Explore How Objects Speak to Us
8 Comments
September 1, 2011 at 1:50 pmit's interesting how Paola find's no reservations in the increasing digital world and how it may affect human interactions and thoughts, to me everything affects everything, our views of products right now and how society works was greatly affected by the industrial revolution, why not the digital one?
September 1, 2011 at 1:49 pmCan't wait to check this out. I really enjoyed Paola's discussion on past and current relationships between "disruptive innovations"!
September 1, 2011 at 1:27 pmWow what an inspiring interview! I'm fascinated by the concepts being explored in this exhibit, and I cannot wait to go.
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All Topics » Homeland Security » Employee training
Employee training (1 - 2 of 2 items) in Past Year
Federal Air Marshal Service: Additional Actions Needed to Ensure Air Marshals' Mission Readiness
GAO-16-764: Published: Sep 14, 2016. Publicly Released: Sep 14, 2016.
The Transportation Security Administration's (TSA) Office of Training and Development (OTD) assesses air marshals' training needs using several information sources, but opportunities exist to obtain more feedback from air marshals on whether the training courses they must take met their needs. OTD primarily assesses air marshals' training needs by holding curriculum development and review conferen...
Aviation Security: TSA Should Ensure Testing Data Are Complete and Fully Used to Improve Screener Training and Operations
GAO-16-704: Published: Sep 7, 2016. Publicly Released: Sep 7, 2016.
The Transportation Security Administration (TSA) uses a variety of programs to train and evaluate Transportation Security Officers (TSO) who are responsible for screening passengers and baggage for threats to aviation security. For example, by law, TSOs must complete 40 hours of classroom training, 60 hours of on-the-job training, and certification tests before performing screening. Once certified...


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I also feel that my Reference II has greater resolution than my Reference I. The scale of the music and spatial projection are noticeably improved. I doubt the Ref I 600 Ohm will be any more spatial. For better imaging than the Ref II, you'd have to use something like the HD800 or the AKG K1000, I reckon.
Edited by o0CosmoMemory0o - 4/10/14 at 1:38am


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ActiveState to Maintain Open-Source Focus
Despite its acquisition earlier this week by a British anti-virus software maker, ActiveState Corp. said it will maintain its focus on development tools and its involvement in the open source community.Despite its acquisition earlier this week by a British antivirus software maker, ActiveState Corp. said it will maintain its focus on development tools and its involvement in the open source community. Sophos Plc, based in Abingdon, U.K., announced its acquisition of Vancouver, British Columbia-based ActiveState in a $23 million transaction late Wednesday. The antivirus company sought ActiveState primarily for its enterprise antispam software, but Sophos chief technical officer told eWEEK that Sophos looks forward to growing ActiveStates tools and languages business as well. Richard Jacobs, chief technical officer at Sophos told eWeek: "Sophos believes there is substantial value in retaining ActiveStates tools and languages business, from both operational and sales perspectives. Internally, we see the use of open source programming languages, such as Perl and Python, to offer the potential for tremendous productivity increases with our core development. To have access to this expertise both within ActiveStates dev team and the open source community as a whole is very valuable."
Jacobs said Sophos will retain all of ActiveStates more than 100 employees in British Columbia. An ActiveState spokeswoman said the company recently released Komodo 2.5, its integrated development environment for scripting languages that runs on Linux, Solaris and Windows. And this fall the company will release a new version of its Extensible Stylesheet Language Transformations (XSLT) plug-in for Microsoft Corp.s Visual Studio .Net, called Visual XSLT 2.0.
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New Security Updates for Ubuntu
Linux developers Canonical has released important security updates for the Ubuntu kernel, strongly recommending upgrades for releases 6.06 LTS, 7.10 and 8.04 LTS and corresponding versions of Kubuntu, Edubuntu and Xubuntu.
The updates became necessary after the discovery of numerous security flaws in the Linux kernel. The direct-10 subsystem fails to validate certain structures, tmpfs implementation is faulty and the NFSv4 does not correctly handle file ACLs. All of these bugs are capable of causing the system to crash or result in a Denial of Service.
A detailed list of bugs is published on the Ubuntu Security Notice USN-659-1. The bug fixes can be applied using the Synaptic, Aptitude and other package-management tools, with a reboot necessary to complete the process.
Additional information is aimed at Ubuntu 8.04 (Hardy Heron) users; with the update pocket disabled, the kernel upgrade will include an unavoidable ABI change and the kernel will be given a new version number. All third party kernel modules will have to be recompiled and reinstalled. Drivers from Ubuntu's own package "linux-restricted-modules" will be updated automatically.
Issue 28: GIMP Handbook 4th Ed./Special Editions
Buy this issue as a PDF
Munich Plans to Ditch Linux and Go Back to Windows
A major setback for the Linux desktop.
Linux Kernel 4.10 Comes with New Security Features
Improved support for GPU in virtualization.
OpenSUSE Site Hacked
News site for the openSUSE community falls victim to a Wordpress exploit.
LibreOffice Goes Online with 5.3 Release
The source code is available online.
Microsoft Brings Clear Linux OS to Azure
One out of three virtual machines on Microsoft Azure Cloud run Linux.
ASUS Announces a Single-Board Computer
The form factor of the board makes it a drop-in replacement for Raspberry Pi.
Red Hat Releases RHEL 6.9 Beta
Makes it easier for customers to move workloads into container-centric applications.
SUSE Working on a New Operating System Called MicroOS
SUSE's answer to container-centric operating systems.
Biggest Kernel Release Ever
Linux 4.9 is the biggest release in terms of number of commits.
CentOS Linux 7 (1611) Released
The latest version of the official RHEL clone is here.


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SHARP Literacy, Inc.
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The trio, all members of a diving club in Folkestone, were thought to be suffering from "the bends" when they surfaced, a Dover coastguard said. He said that a helicopter had first planned to take the three men to a decompression unit at Portsmouth, Hampshire, but it was unable to land because of fog. The next nearest unit was in Ostend.
- More about:
- Dover
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Grand Istana Rama Hotel Bali
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Minbar in room
- Airport Transportation
- Spa
- Suites
- Room service
- Swimming pool
Photos of Grand Istana Rama Hotel Bali
Travelers also recommend:
- Spa
- Kids pool
- Beach
- Swimming pool
- Restaurant
- Minbar in room
- High-speed internet in room
- Breakfast Available
- Wireless internet connection in public areas
- Smoking rooms available
- Refrigerator in room
- Non-smoking rooms
- Air-Conditioning
- Wheelchair accessibility
- Free parking
- Suites
- Airport Transportation
- Conference facilities
- Room service
- Multilingual staff
- Business Services
- Meal plan
- Kids activities or Babysitting
TravelPod Member ReviewsGrand Istana Rama Hotel Bali Kuta
This is hotel is exactly in front of famous Kuta beach. The services is good, got a lot of freebies when check in at the counter but the building is kinda old and need a lot of renovation & maintenance.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews Grand Istana Rama Hotel Bali Kuta
Travel Blogs from Kuta
We Tanah Lot
... it hilarious. I was furious at my brother however. The day finished on a high when one of my best friends was at the villa waiting for us when we got back, my girlfriend had secretly organised him to stay with us as he was visiting bali himself at the same time. The night ended with a few of us going out for a night on the tiles, which was an experience as it was still 30 degrees and we were pretty much in flip flops and shorts! Photos: Indonesia ...
Indonesia Review
... though. Yogyakarta Atmosphere - 3 Heritage - 4 Expense - 3 Entertainment - 3 Accessibility - 3 Overall - 3.2 Comments - A world away from Jakarta the city appeared welcoming and with plenty to do for tourists. The natural heritage spots around the city compliment the religious differences in Indonesia and are beautiful to look around. There's plenty more we didn't do here but three nights would be ...
Respec' my Authorita!
... there with my bags that put me off) I found a lovely place in the centre, booked myself on a cooking course, bought a ticket for the legong (traditional Balinese dance) that evening and then chilled over dinner and far too much salak (snake fruit, despite having eaten soo many of them over the past few days that I feel a bit sick, I'm still sitting here munching on them now). Legong: Considered by some to be the most graceful of Balinese dances, you are most likely to see ...
Temple run
... stop at the Monkey forest. Apparently it's almost identical to the one practically on our doorstep in Ubud so we did think maybe it was a bit pointless. However, we were told the monkeys here were less aggressive so that definitely helped ease Niomis mind as she finds some animals quite frightening. I'm so glad we did it because se got to have monkeys jump all over us with their cute little babies and we managed to get the best photos. At first it was a bit daunting having ...
Lembongangstas Paradise
... up diverting to KK, we'll take it as a sign and just go ahead and move there permanently. After 6 more hours in KK, it was finally time for our flight to Bali!
Nusa Lembongan is a small island off the coast of Bali, and is known for being the Bali that people dream of but rarely find. We had a brief stopover in Sanur (on the main island of Bali) after our flight, then took a speedboat over. As we approached, the rugged cliffs of the coastline dominated ...


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Lost Odyssey: Seeker of the Deep Xbox 360
- Publisher: Microsoft Game Studios
- Release Date: May 23, 2008
- Summary: Find the secret to the experiments performed deep in this destroyed research complex. Enemies lurk in the deep, including a powerful new boss, but so do exclusive items. Note: Save your game before you enter the "Experimental Staff Remains."
- Developer: Mistwalker
- Genre(s): Role-Playing
- # of players: 1 Player
- Cheats: On GameFAQs
- More Details and Credits »
Score distribution:
Positive: 0 out of
Mixed: 0 out of
Negative: 0 out of
Score distribution:
Positive: 1 out of 1
Mixed: 0 out of 1
Negative: 0 out of 1
Jul 3, 2012I have played role playing game for over 25 years now, so as you can image I play alot of RPG on my XBOX360 and one of my personal favouritesI have played role playing game for over 25 years now, so as you can image I play alot of RPG on my XBOX360 and one of my personal favourites is Lost Odyssey. It has wonderful music, great characters, a nice story line with lots of twists and turns and in my view a simple a easy to understand battle and magic system to use. I have read about reviewers complaining loading tims of 30 seconds, slow frame rates and no original story line, Well this takes nothing away from the game and if you install the game it cuts the loading times down alot and I found nothing wrong with the frame rate on my XBOX and story is great and it took a couple hours to guess it when I first played this game.
You play Kaim Argonar a Lieutenant in the army , who starts the game with no memory of his past and your job is to find people who will help you undercover what going on in this world and hopefully gain Kaims memories in process. This a really Good RPG well under rated and I would highly recommend to you as must have game on the XBOX360..My Score is 10/10 BRILLIANT GAME........I LOOK FORWARD TO LOST ODYSSEY 2 OUT SOON I HEAR...… Collapse


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"Pour up (Funrun) Head shot (Funrun) Sit down (Funrun) Stand up (Funrun) Pass out (Funrun) Wake up (Funrun) Faded (Funrun), faded (Funrun)"
Related quotes
"Play with life, laugh with life, dance lightly with life, and smile at the riddles of life, knowing that life's only true lessons are writ small in the margin."
"Keep in mind that in the game of life, there is no scoreboard, but the clock is ticking... enjoy it..."
"I guess I just prefer to see the dark side of things. The glass is always half empty. And cracked. And I just cut my lip on it. And chipped a tooth."
"Life is a game,you are told the rules,then you have to manage how to keep going by them,until the game ends,then you will be told your score depending on how well you followed the rules."
"All those girls that I used to get over you ,are all gone and they moved on with their life's and the saddest thing is that i still can't get over, now they are all happy with their love ones while I cry to bed every night thinking about you and what I should have done. Dezinha19"


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A great way to keep your bite valve clean and protected from dust and grime. Works in conjunction with Ergo Hydrolock, inline Hydrolock or ergo angle. Does not fit directly onto tubing.
Thank you for visiting Camelbak Bite Valve Cover Hydration System Spares on oakleysbikes.co.uk
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Invaluable cannot guarantee the accuracy of translations through Google Translate and disclaims any responsibility for inaccurate translations.
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Lot 466: Lot of 3 Yellow & Red COCA-COLA Wood Crate Trays.
Pepsi, Coca Cola, and Soda Pop Collection - 500 Lots - Vintage Advertising
by Kraft Auction Service
29 October 2016
Lebanon, IN, USALive Auction
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Description: 3 Different crates as shown.
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