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Mitogen activated protein (MAP) kinases are serine/threonine kinases that mediate signal transduction and orchestrate cellular responses to environmental stress. In mammalian cells, three principle MAP kinase pathways have been identified, including c-Jun N-terminal kinase (JNK), extracellular regulating kinase (ERK), and p38 MAP kinase. p38 is thought to be especially relevant to rheumatoid arthritis (RA) because it is activated in RA synovium and regulates key mediators implicated in the disease. It is regulated by two main upstream MAP kinase kinases, namely MKK3 and MKK6. Despite pre-clinical evidence that p38 blockade should be beneficial in RA, only modest improvement has been noted in clinical trials when patients are treated with p38 inhibitors. This observation might be due to increased activation of ERK and JNK and suppression of anti-inflammatory cytokines like IL-10 by p38 inhibitors. Understanding the mechanisms that limit efficacy is crucial to developing effective new targeted therapies. We now hypothesize that targeting MKK3 or MKK6 might be more effective than traditional p38 inhibitors in diseases like RA. This proposal will explore the biology of MKK3, MKK6, and p38 and test our hypothesis by 1) determining if targeting MKK3 or MKK6 instead of p38 in murine arthritis models preserves IL-10 production and prevents increased activation of other MAP kinases;2) determining the mechanisms of differential IL-10 regulation and ERK/JNK signaling by MKKs and p38 in cultured macrophages;and 3) determining if p38 blockade suppresses IL-10 and activates ERK/JNK in RA samples and whether this is prevented by targeting MKK3 or MKK6. In addition, a program to evaluate potential MKK3 and MKK6 inhibitors will be initiated to translate the results into a potential therapy. If successful, these studies will support development of novel MAP kinase kinase inhibitors for RA.
Despite the introduction of biologics, rheumatoid arthritis remains an unmet medical need with a requirement for less expensive and more effective oral therapies. We have proposed targeting upstream kinases in the MAP kinase cascade to address this need. The planned experiments are highly relevant to the goals of the NIH because they focus on a novel therapy for rheumatoid arthritis.
|Guma, M; Sanchez-Lopez, E; Lodi, A et al. (2015) Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis 74:1399-407
|Leinders, Mathias; Koehrn, Fred J; Bartok, Beatrix et al. (2014) Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain 155:1150-60
|Boyle, David L; Hammaker, Deepa; Edgar, Meghan et al. (2014) Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss. PLoS One 9:e84818
|Stanford, Stephanie M; Maestre, Michael F; Campbell, Amanda M et al. (2013) Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum 65:1171-80
|Bottini, Nunzio; Firestein, Gary S (2013) Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol 9:24-33
|Kolker, S J; Walder, R Y; Usachev, Y et al. (2010) Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release. Ann Rheum Dis 69:903-9
|Gorovoy, Matvey; Gaultier, Alban; Campana, W Marie et al. (2010) Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol 88:769-78
|Fukushima, Akihisa; Boyle, David L; Corr, Maripat et al. (2010) Kinetic analysis of synovial signalling and gene expression in animal models of arthritis. Ann Rheum Dis 69:918-23
|Bartok, Beatrix; Firestein, Gary S (2010) Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 233:233-55
|Blewis, Megan E; Lao, Brian J; Jadin, Kyle D et al. (2010) Semi-permeable membrane retention of synovial fluid lubricants hyaluronan and proteoglycan 4 for a biomimetic bioreactor. Biotechnol Bioeng 106:149-60
Showing the most recent 10 out of 21 publications


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André Leon Talley's 60th Birthday: See His Most Outrageous Outfits! (PHOTOS, POLL)
Huffington Post | Hilary Moss | Posted 05.25.2011 | Style
Read More: Andre Leon Talley Anna Wintour, Andre Leon Talley Clothes, Slidepoll, Andrew Leon Talley the September Issue, Andre Leon Talley Vogue, The September Issue, Andre Leon Talley, Andre Leon Talley Style, Fashion, Style News
Vogue's American editor-at-large André Leon Talley is hard to miss. The six-foot-seven stunner is likely the only person in the fashion front rows ro...

subset: commoncrawl


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Miami Marlins v Milwaukee Brewers
MILWAUKEE, WI - JULY 04: Josh Johnson #55 of the Miami Marlins pitches against the Milwaukee Brewers during the game at Miller Park on July 04, 2012 in Milwaukee, Wisconsin. (Photo by Mike McGinnis/Getty Images)
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Flight Schedules from Tarapoto to Tacna
Find cheap airfares for flights from Tarapoto to Tacna. Use Wego.com to search and compare low airfare airline tickets for Tarapoto to Tacna flights on various international airlines. FInd last minute flights and the latest low airfares for this route. Compare cheap Tarapoto to Tacna flights at a glance and get the best deal for your trip.
Besides Tacna flights, find cheap hotels and quality accommodation in Tacna with Wego. Search and compare Tacna hotels online to book your ideal travel accommodation.


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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Showing Results: Most Recent
This review is from: Sigma 2x EX DG APO Autofocus Teleconverter for Canon EOS
Pros: Read the specs..
I've had good Sigma gear and passable. Here's the deal. Read specs.
I've done well with this one, but I paid attention to the specs.
Canon tells you in specs that lenses won't autofocus at less than f/5.6. This lens with a 2x is never more than F/8, usually less. In good light with enough contrast, maybe. Learn to manually focus unless you've got a bundle of money for a really fast telephoto. To be reasonably sure of autofocuse, you need at least an f/2.8 to get f/5.6 with this.
Secondly, I once bought a Canon extender and learned that it didn't work except with Canon and only a few others. It's not unusual. This Sigma works with some, not all 3rd party brands. Canons with work with non-comparitble lenses, not necessarily true the other way. . TAlk to the dealer. It will avoid problems. I know how you feel. Call New Egg, but don'r complain because you guessed wrong.
Cons: None, except, see pros. Not a con per se, but the best of the extenders are aimed at specific lenses and their optical designs. There's nothing wrong with general telex tenders, but the more lenses they handle, the less they're designed for one lenses particular optics.
Other Thoughts: Users need to be responsible for what they buy. I have all but tossed out Sigma lenses, but others, not so. Pay attention to what you buy. Don't accept myth an don't assume too much. Saying something has AF doesn't mean it will AF with this or that -- or that it will work with all lenses.READ FULL REVIEW
This review is from: Mediasonic HFR2-SU3S2FW Raid 0 (Spanning) JBOD Raid 0 (Stripping) Raid 1 (Mirroring) Raid 3 (Stripped set with dedicated parity) Raid 5 (Striped set with distributed parity) Raid 10 (Mirroring + Striping) 4 3.5" Drive Bays USB 3.0 eSA
Pros: It's easy to set up and it's been no problem since installation other than drive going bad. I personally feel the need for Firewire and I can't speak to USB 3.0 because I don't have it. I have the USB 2.0 model, but appears to be no basic changes.
For Macs, the dual FW800 makes a daisy chain a snap. As it is, I use this in Raid 5 with 4 2TBs on my desk. It's just a whole lot faster than my NAS which serves a different purpose.
Cons: The new version is pricier, but not outrageous, and in any event I bought it on sale. Most of the build is solid, but I find the front door a little shoddy. Documentation, unless something has changed, is all but nil, but can be found on line at Mediasonic site.READ FULL REVIEW
This review is from: Mediasonic HFR2-S3B RAID 0 / 1 / 3 / 5 / 10 4 3.5" Drive Bays USB 2.0 eSATA Firewire 400 (1 Port) Firewire 800 (2 Port) PRORAID Box 4 Bay Raid Enclosure with USB 2.0, eSATA & FireWire 400/800
Pros: Cheap, Not Cheesy, 6 TB storage w/RAID 5, Outstanding connectivity for those needing Firewire 400 or 800, USB quick assembly, Quiet, easy fan replacement if needed. Very compact for Desktop.
Cons: Slightly cheesy front door mount, but it works well. E-SATA note specs requiring port multiplication(I don't). Documentation is a bit weak. Included are skimpy. YOU NEED TO USE WEBSITE. If you get a drive error indication, you did something wrong.
Other Thoughts: I needed bigstorage I could use on line with an iMac quad or plug into the MBPro laptop. The FW800 is perfect for that. If you don't need or want FW, pay attention, the same box is cheaper with few connects.
I filled the box with 4 Seagate 2TB Green drives, i.e. 5900 rpm. They run cool and quiet other than the fan occasionally waking up. They're plenty fast for this purpose.
FWIW, I've seen complaints on the 2TB limit, but my hugely more costly Thecus NAS has five 1 TB drives, the Thecus limit. It's a great NAS, but it cost a whole lot more, I need more room and the FW is faster than the net. I might consider another Mediasonics and jumper the FW if I need more.


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Redrawn from the cover of Reggie and Me #28.
Script revision by Craig Delich from Bill Kresse to ? The Who's Who indicates that Kresse was an artist and letterer, but not a writer. No extant evidence known proves otherwise.
Page count needs confirmation, when reprinted in Jughead's Double Digest (Archie, 1989 series) #157 the story has 6 pages.
One of Mrs. Lodge's causes in the final panel is "Prune Fungus Week." The nonexistent disease "Prune Fungus" is a running gag in Bob Bolling's stories.


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Acrylics keep people from shamefully hiding their unkempt hands in pockets, mittens, or two wedding cakes. Keep your hands held high with this Groupon.
Choose Between Two Options
- $39.50 for one full set of acrylic nails and first refill. Includes a free buff down and polish 7 to 10 days after initial appointment (a $90 value)
- $27 for two acrylic-nail refills, polish, and UV top coats (a $60 value)
Tonya's Nail Salon
After more than 30 years of business, Tonya's Nail Salon has become an area favorite—not only for its nail services, but also for its complimentary glasses of wine and cups of coffee from the beverage bar. While guests relax, the seasoned staff trims fingernails and toenails, gently grooms cuticles, and swipes nails in layers of vibrant OPI polish.
Customer Reviews
14902 N Florida Ave.
Suite F
Tampa, FL 33613
+18139609700Get Directions


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Vaalwater Lodge Accommodation
If you are looking for Vaalwater holiday accommodation , SafariNow has a selection of Self-catering, Safari, Lodge holiday accommodation in Vaalwater and surrounds. With 42 listings in Vaalwater, our handy Vaalwater map search and great low prices, it's easy to book the perfect holiday accommodation for your Vaalwater visit.)We also have some great special accommodation deals in Vaalwater South Africa
Did you know? Vaalwater Accommodation is often misspelt. Here are some variations:
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You can choose from a wide range of Kruger Park safari lodge accommodation


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BLM Maps
Map: Borrego Valley - Surface Management
Agency: BLM
Map covers much of Anza Borrego Desert State Park surrounding Borrego Valley, several small sections of Cleveland National Forest, and several sections of BLM lands. From Ramona CA travel north or east to access the national forest with camping and hiking opportunities. East of Ocotillo Wells is the Ocotillo Wells State Vehicular Recreation Area and Arroyo Salada Open Area both with OHV use activities. Explore the Anza Borrego Desert SP with numerous points of interest, several campgrounds, scenic areas, hiking trails, and historic sites. Backside of map has extensive information about the designated 25 million acre California Desert Conservation Area. Includes descriptive information about the places on the map, along with available recreational activities such as camping, hiking, horseback riding, and 4 Wheel/OHV driving. Official Bureau of Land Management metric topographic map @1:100,000 scale (roughly 3/4"=1 mile), color-coded to show surface management, i.e. agency vs. private or tribal ownership.
This map shows color-coded public and private ownership, roads, water features, recreation sites, points of interest, county boundaries, and the township and range lines. Maps show trails, roads, and developed recreation areas such as campgrounds. Use this map for Deer Hunting in Units D15, D16 and D19. 2009
Item No. BORREGOVALLEY
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The above map may be useful for the following recreation destinations: Agua Tibia Wilderness, Anza-Borrego Desert State Park, Beauty Mountain Wilderness, Boden Canyon Ecological Reserve, Crestline Group Campground, Dripping Springs Campground, Fish Creek Mountains Wilderness, Fry Creek Campground, Indian Flats Campground, Oak Grove Campground, Observatory Campground, Ocotillo Wells Vehicular Recreation (OHV) Area, Palomar Mountain State Park, San Felipe Valley Wildlife Area, Santa Rosa Wilderness
Other Maps
California Road and Recreation Atlas
Agency: Other
A great atlas to have for residents or travelers. Each recreation guide page gives suggestions for campgrounds/RV parks, hiking trails, beaches, ocean or river fishing sites, natural or historic attractions, and museums. Benchmark maps are maps for the true public lands lover. The California Road & Recreation Atlas now has 14 pages of all-new Landscape "Metro Maps" of the four largest urban areas of the state: Los Angeles, San Francisco, San Diego and Sacramento. The enlarged scale (1" = 2.5 miles or 1:157,000) shows even more recreation detail than before. New features of the twenty-eight page Recreation Guide now include climate graphs, eight-classes of public lands ownership, shaded relief and point-to-point mileages. All the maps feature beautifully detailed, digitally rendered landscape relief. The maps are fully compatible with GPS technology. The scale for most of the state is 1:300,000 or 1"= 5 miles. Updated 2015.
Item No. 0-929591-43-7
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The Department of Medical Informatics &Clinical Epidemiology (DMICE) of Oregon Health &Science University (OHSU) is submitting this competitive renewal for a fifth five-year cycle of the National Library of Medicine (NLM) Research Training in Biomedical Informatics Program. The overall objective of our program remains the same in aiming to train future researchers, faculty, and/or leaders in the field of biomedical informatics. The rationale for these objectives is that individual health, health care, public health, and biomedical research can be enhanced through the application of the theory and practice of biomedical informatics, the field devoted to the optimal use of information, usually with associated technologies, to improve human health. The design of our program is for predoctoral fellows to pursue a PhD in biomedical informatics and for postdoctoral fellows to obtain further training that includes a research master's degree if they have no prior degree in biomedical informatics. The educational program for all trainees consists of coursework, a substantial research project, and associated publications, presentations, and other academic activities related to research. In this funding cycle, we propose to maintain a steady state of ten predoctoral fellows (including one dental trainee), eight postdoctoral fellows (including two dental trainees), and four short-term diversity trainees. The OHSU Biomedical Informatics Fellowship Program has been a leader and innovator in the NLM training grant program. In this next funding cycle, we aim to build on its past success by: 1. Improving and expanding coursework and research experiences for predoctoral and postdoctoral fellows, especially in transformational areas such as health care delivery reform, translational research, and emerging technology platforms 2. Enhancing our evaluation and tracking of progress of fellows during their training 3. Achieving greater diversity among our fellows and insuring their success 4. Continuing our leadership in the NLM training program and other informatics education initiatives nationally and globally.
The Oregon Health &Science University (OHSU) Biomedical Informatics Fellowship Program trains future researchers and leaders in biomedical and health informatics, the field devoted to improving personal health, health care, public health, and biomedical research through the use of information and its associated technologies. This National Library of Medicine (NLM) Training Grant will enable us to support predoctoral (PhD students) and postdoctoral fellows for training that includes courses, research, and related activities. This proposal is a competitive renewal for a fifth five-year cycle of funding for the OHSU program, which has been a leader and innovator in the program for 20 years.
|Blucher, Aurora S; McWeeney, Shannon K (2014) Challenges in secondary analysis of high throughput screening data. Pac Symp Biocomput :114-24
|Gibbs, David L; Gralinski, Lisa; Baric, Ralph S et al. (2014) Multi-omic network signatures of disease. Front Genet 4:309
|Vingara, Lisa K; Yu, Hui Jing; Wagshul, Mark E et al. (2013) Metabolomic approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis. Neuroimage 82:586-94
|Mooney, Michael; McWeeney, Shannon; Sekaly, Rafick-Pierre (2013) Systems immunogenetics of vaccines. Semin Immunol 25:124-9
|Mooney, Michael; McWeeney, Shannon; Canderan, Glenda et al. (2013) A systems framework for vaccine design. Curr Opin Immunol 25:551-5
|Kahn Jr, Charles E; Kalpathy-Cramer, Jayashree; Lam, Cesar A et al. (2012) Accurate determination of imaging modality using an ensemble of text- and image-based classifiers. J Digit Imaging 25:37-42
|Ash, Joan S; Sittig, Dean F; Guappone, Kenneth P et al. (2012) Recommended practices for computerized clinical decision support and knowledge management in community settings: a qualitative study. BMC Med Inform Decis Mak 12:6
|Ash, Joan S; Sittig, Dean F; Wright, Adam et al. (2011) Clinical decision support in small community practice settings: a case study. J Am Med Inform Assoc 18:879-82
|Ash, Joan S; Sittig, Dean F; McMullen, Carmit K et al. (2011) Studying the vendor perspective on clinical decision support. AMIA Annu Symp Proc 2011:80-7
|Kalpathy-Cramer, Jayashree; Bedrick, Steven D; Boccia, Kelly et al. (2011) A pilot prospective feasibility study of organ-at-risk definition using Target Contour Testing/Instructional Computer Software (TaCTICS), a training and evaluation platform for radiotherapy target delineation. AMIA Annu Symp Proc 2011:654-63
Showing the most recent 10 out of 42 publications


text: High-End Google Nexus Tablet to Launch This Summer?Kat Hannaford3/28/11 7:40amFiled to: TabletsGoogle nexus tabletNexus tabletGoogleneXusTabletLgLg nexus tabletHoneycombHoneycomb tabletsHoneycomb tabletunconfirmedRumorRumors0EditPromoteShare to KinjaToggle Conversation toolsGo to permalinkSince the Nexus One phone, we've seen a spate of other Nexus-named devices, which Google is said to have a direct hand in helping build. These are reference devices that showcase the latest Android software, and usually have high-end specs to match. Advertisement Therefore it makes a lot of sense for Google to want a Nexus tablet to be the reference Honeycomb device. People are pointing at LG as being behind the build, but if you think it'll just be another T-Mobile G-Slate, I'd think again. At least, I'm hoping. [Mobile-Review via Xataka via AndroidCommunity]ReplyLeave a reply


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Spring is just around the corner and for many school districts that means PSSA testing time. Most local parents will treat this period just like any other school day, kiss their kids before they hop on the bus and assume that all is well inside the school house. I am here to tell you it's not.
The "reformers" who think that just one test can really tell you how your child is doing in school would like us to think the test is benefiting our children. It's not.
For the past five months most classrooms have been devoid of intellectually stimulating classroom experiences. Our children have been forced to complete worksheet after worksheet in language arts and mathematics, while social studies and science classes have been shortened to allow more time for reading and math instruction. Five months of boredom and mindless routine. How much can they take before just the thought of going to school immobilizes our children? There is real damage being done to our kids because of these standardized tests. Something has to happen.
I'm here to tell you, in Pennsylvania, parents have the right to have their children exempted from the PSSAs. According to the Pennsylvania Department of Education, if you believe it is morally wrong to put your kids through the ordeal of a week of pointless testing, that's good enough. You don't have to say why. Your request cannot be challenged or denied by law.
I urge all parents to contact their schools and opt their children out of these mindless tests. The scores of these tests do not determine grades. They do not determine college acceptance. They don't even have to be used for AP or honors placement in high school. You can insist the school look at grades only. So why are we forcing our children to take them? Let's bring real education back to our schools in Pennsylvania. Let's stop the yearlong test prep that has supplanted real teaching and learning.
The writer is a teacher.


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You've just received a phone call advising that one of the school's employees is being sued for engaging in inappropriate activity with students attending the birthday party for the employee's child. The parent tells you that he is also considering bringing a claim against the school. This type of situation is occurring with more frequency today. Unfortunately, many schools have not yet taken action to assess the potential school liability for an employee's off-duty behavior.
How Do The Liability Issues Arise?
When employees engage in off-campus activities (some of which are school related), the risk of claims increases because the level of supervision decreases and the structure of the environment changes. The issue of off-duty or off-campus interaction with students arises in several contexts. In some situations, the employee is in charge of some type of off-duty activity (such as a pizza party, field trip, or other activity).
Please see full article below for more information.
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Celeb Author Hannah Andrusky Talks Brain Injury in New Self-Help, Living the Invisible Disability
When a serious accident waylaid Hannah Andrusky's career and left her struggling for normalcy, she fought back.
Los Angeles, CA, US., May 4, 2014 - (PressReleasePoint) - A traumatic accident left businesswoman and talk show host Hannah Andrusky with injuries that weren't readily apparent – but were no less debilitating. Andrusky shares her story and advice for others in similar situations with her new self-help book, Living the Invisible Disability: Coping With Post Concussion Syndrome Traumatic Brain Injury & Depression, published by Outskirts Press.
In 2011, Andrusky was involved in a serious car accident that temporarily derailed her career and left her with long-term medical complications. As she battled her way back to recovery, she threw herself into her work, including Miami's Watch 305, and later "Press Pass," in which she interviewed sports stars in their personal spaces.
Looking back, Andrusky came to view that accident as a blessing in disguise – one that led her to rediscover her passion for "real" people and their stories. As she lived with her own invisible disability, she developed more empathy for others who suffered silently. Now, through her talk show, "Hannah Talk," she helps everyone find a voice. Through her own struggles with brain injury, she wrote the book Living the Invisible Disability to help others through their journey. The book is filled information about traumatic brain injury, as well as advice and practical tips for healing from the inside out.
Hannah Andrusky now serves as ambassador for the Invisible Disabilities Association, a nonprofit organization founded in 1997 that strives to bring awareness to hundreds of misunderstood, invisible disabilities.
Living the Invisible Disability: Coping With Post Concussion Syndrome Traumatic Brain Injury & Depression is available online through Outskirts Press at www.outskirtspress.com/bookstore. The book is sold through Amazon and Barnes and Noble for a maximum trade discount in quantities of 10 or more, and is being aggressively promoted to appropriate markets with a focus on the self-help, medical and body, mind and spirit categories.
ISBN: 978-1-4787-2900-6 Format: 6 x 9 paperback cream Retail: $13.95
Kindle: $9.99 Nook: $9.99 iPad: $9.99 eBook: $5.00
Genre: Self-Help/Medical/Body, Mind & Spirit
For more information about Living the Invisible Disability, visit the book page at the author's webpage, www.OutskirtsPress.com/livingtheinvisibledisability.
About the Author: Hannah Andrusky is a talk show host, stylist, businesswoman, author, mom, daughter, sister and friend. She is an advocate for positive and spiritual change, which is the focus for her show, "Hannah Talk." She became a mother at 18, married and then divorced nine years later. A successful stylist for 18 years, Andrusky worked with clients in Montana, L.A., Las Vegas, San Diego, New York and Miami, including celebrities. It was on this "stage" that she honed her interview style and was encouraged to pursue a media career. Soon she was co-hosting "Sanctuary of Style," a style and fashion blog, where her positivity, humor and pragmatism proved hugely popular. Andrusky now lives in Los Angeles with her son, Jordan. For more information about Hannah Andrusky, visit the author's website, www.HannahTalk.com.
About Outskirts Press, Inc.: Outskirts Press offers full-service, custom self-publishing and book marketing services for authors seeking a cost-effective, fast, and flexible way to publish and distribute their books worldwide while retaining all their rights and full creative control. Available for authors globally at www.outskirtspress.com and located on the outskirts of Denver, Colorado, Outskirts Press, Inc. represents the future of book publishing, today.
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- Flames of Cold Fire: Women Overcomes Mental Abuse and Race Hate in New Non-Fiction
- New non-fiction from Outskirts Press focuses on a family's struggle with their son's traumatic brain injury
- Calling All Baby Boomers! Expert Reveals Three Steps to Heal and Attract the Life You Love
- Flower Girl Trilogy Launches with Wind Flowers: Book One, a Tale of Loves Lost and Found
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Was thumbing through my copy of Schmidt the other day and a white-leafed
hosta caught my eye. Ran (I think) also mentioned a white leaved variety in
one of his posts.
What has been your experience with these plants? Sun, shade? Do they
require a lot of coddling (which would be my guess)? Are they viridescent
or do they retain that cream color all year? Or conversely, do they start
yellow and bleach to creme?
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The Netherlands Supports Palestine Refugees in Gaza
East Jerusalem
The Government of the Netherlands has contributed US$ 1.97 million to support the United Nations Relief and Works Agency for Palestine Refugees (UNRWA) emergency assistance programme in the Gaza Strip. This contribution is vital to improving living conditions in the coastal strip, where the population faces a continued downward spiral as a result of the blockade imposed on it for the past eight years.
"This contribution shows the continued support by the Netherlands for the people in Gaza," the Representative of the Netherlands Birgitta Tazelaar said. To help improve living conditions, the Netherlands has supported agriculture, cultural activities and the promotion of human rights. Ms. Tazelaar emphasized that humanitarian aid is not a permanent solution and that sustainable improvement is the only way to permanently improve people's future. "In order to achieve that, whilst taking into account Israel's legitimate security needs, the economy of Gaza needs to be allowed to grow again, which requires opening the borders of Gaza for people and goods," she said.
UNRWA's Director of External Relations and Communications Salvatore Lombardo thanked the Government of the Netherlands for its continued commitment to helping Palestine refugees. "The situation in the Gaza Strip has become very difficult. With food insecurity on the rise, we have witnessed a tenfold increase in the number refugees relying on UNRWA food assistance since 2000," he said. Mr. Lombardo added: "It is only with the help of generous partners, such as the Government of the Netherlands, that we are able to help refugees meet their basic needs."
Background Information
UNRWA is a United Nations agency established by the General Assembly in 1949 and is mandated to provide assistance and protection to a population of some 5 million registered Palestine refugees. Its mission is to help Palestine refugees in Jordan, Lebanon, Syria, West Bank and the Gaza Strip to achieve their full potential in human development, pending a just solution to their plight. UNRWA's services encompass education, health care, relief and social services, camp infrastructure and improvement, and microfinance.
Financial support to UNRWA has not kept pace with an increased demand for services caused by growing numbers of registered refugees, expanding need, and deepening poverty. As a result, the Agency's General Fund (GF), supporting UNRWA's core activities and 97 per cent reliant on voluntary contributions, has begun each year with a large projected deficit. Currently the deficit stands at US$ 69 million.
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79th Texas Legislature, Regular Session, House Bill 3489, Chapter 229
Description: Bill introduced by the Texas House of Representatives relating to the creation of an additional statutory county court in Brazoria County.
Date: May 27, 2005
Creator: Texas. Legislature. House of Representatives.
Item Type: Legislative Document
Partner: UNT Libraries Government Documents Department


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Tender Armor Adding New Layer of Security to Credit Card Transactions
The startup's CvvPlus fraud prevention technology provides another layer of authentication via a randomly generated CVV number sent to the credit card holder.Privately held security startup Tender Armor today is exiting stealth mode with the announcement of its CvvPlus credit card fraud prevention technology. On the back of almost every major credit card there is a Card Verification Value (CVV), which is a three-digit number that is used by banks and payment processors to verify payments when the physical credit card is not present—for example, with online transactions. (American Express cards have a four-digit number on the front of the card.) The CVV is a static number on a consumer's printed credit card and as such is at risk when a credit card itself is stolen. The goal with Tender Armor's CvvPlus technology is to provide another layer of authentication via a randomly generated CVV number that is sent to the credit card holder, much like a two-factor authentication token for common types of Web access. "We built the system from scratch and have filed for patents on it," Tender Armor CEO Madeline Aufseeser told eWEEK. When a customer uses a point-of-sale (PoS) terminal, the authorization process for a credit card occurs within seconds, Aufseeser said. The authorization process verifies that cardholders are who they say they are, the card is in good standing and there are funds to approve the transaction. What Tender Armor is doing, she said, is adding another element, such that a bank can check for the CvvPlus code that is coming in to determine the validity of a given credit card.
"We communicate with the authorization platform with batch files in an asynchronous manner to give them the CvvPlus codes that we produce in our system," Aufseeser said.
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Topics For Life
Do you need to find a word that rhymes with the word of your choice? This tool has helped me on numerous occasions. I purposefully tried to stump it and couldn't! Next time you need a rhyming word and are drawing a blank try :
Views: 1289
Tags: Education
Children | Education
Do you need a word but you have no clue what you are searching for? I had this situation recently and needed words that ended in y-consonant-e for a phonics lesson but couldn't think of anything other type and hype. I went through the alphabet yBe, yCe, yDe, etc. Most words were obscure and not for my third grader but I did find a few that were relevant such as the name Bryce which is the name of her good friend.) Just type in whatever pattern you are looking for and then go through the alphabet if you don't have any clue.
Views: 1467
This coupon code for iherb.com gives you $5 off your first order: . As far as I can tell it doesn't expire.
My review of iherb.com:
My orders with iherb.com have come promptly and are well packaged. I have found several items I purchase regularly on iherb.com that are less expensive than I can get through two of my co-ops and other discount websites. As with any place though, you have to check the pricing since I have found a few items that were not less expensive. Here are the things I like the most about iherb.com 1. Many items are less expensive 2. Variety of items offered 3. Rewards program 4. They list the expiration date of each product so you know whether you should stock up or just get a few pieces 5. Free shipping over $20 and free 3 day shipping over $40 6. Surprise discounts that aren't always advertised (the first time I ordered for them I received 10% off the items in my cart in a sale that wasn't even advertised and then got a 5% discount on the next order!
With these kinds of deals and promotions, iherb.com is likely to become a major player in the natural foods and supplements websites out there today. I know I will certainly be using them!
Views: 6406
Tags: iherb.com, review, coupon, vegan, gluten free, supplements, healthy foods
How to Make Popcorn on the Stove: Old Fashioned, Homemade Popcorn without a Microwave
Dairy Free, Vegan, Gluten Free, Super Delicious, Kid Friendly Party Food!!
Once you have really good homemade popcorn, you may never go back to the bag in the microwave kind. I opted to move away from microwave popcorn and plastic air poppers because of the plastic issues from the bag lining and heating up plastic in a popper. What I found was that popcorn made on the stovetop is easy, fast and the most delicious stuff I have ever eaten. I don't even like popcorn and love this stuff!
3 Tbs. of Coconut Oil for popping (I used refined organic coconut oil from Spectrum that I purchased for $5.99 a jar at Walmart because A. it came in a glass jar B. It is organic C. It is readily available at a good price D. refined coconut oil means less coconut taste and E. It is one of the safer oils to use at higher temps)
1 Tbs. Coconut Oil, Vegan Butter (I use Earth Balance Soy Free when I use Butter), or Butter of your choice for tossing the popcorn in for flavor. (This is optional but my family doesn't really like dry popcorn.)
1/3 to 1/2 Cup Popcorn (Trader Joe's Organic popcorn is great for trying this recipe as it is inexpensive and tasty) This will be dependent on the size of your pot. If your pot is 4 QTs, I would try the 1/3 cup first. I can just fit ½ cup popped corn in my 4 QT pot of choice but it lifts the lid at the end and could be potentially unsafe. If you have a larger pot you can easily do the ½ cup or more.
Salt to Taste
Stainless Steel Big Pot with Lid and Pot Holders
Big Bowl
Scrape 3 tbs. of oil into pot. Turn heat up to medium high (on my stove top the number 8 is the best setting). Once all oil is completely melted (don't let it start smoking!), drop in 3 kernels of popcorn and cover with the lid. Give it a gentle shake. Watch or listen for three pops. Once all three kernels pop, remove the pot from the burner, add the remainder popcorn, put the lid on immediately and starting counting for 30 seconds. Give it a gentle shake or two while counting if you can. At the end of 30 seconds put the popcorn back on the burner. (The 30 second trick is really important as it gets all the corn heated to about the same temperature to ensure even popping).
Give the popcorn pot a few shakes every now and then and listen for the pops to start. As they start popping, hold the lid and your pot with your pot holders and give it gentle shakes every now and then to make sure the popcorn doesn't stick to the bottom and burn. Once the popping slows to 2-3 seconds in between each pop, hold the pot off the burner but over it and let it have a few more pops before setting down in a heat safe location. Wait until all popping has stopped for at least 30 seconds. Pour into a big bowl. Heat your oil/butter of choice in the hot pan until melted. Pour it over the popcorn, add your salt if using and toss to coat. Enjoy while warm and fresh!
Views: 10431
Tags: Popcorn, Healthy, Organic, Coconut Oil, Recipe, Cooking, Best Tasting popcorn, stove, snack, no microwave, Dairy Free, Gluten Free, Kid Friendly, Vegan, Food For Parties
Cooking | Recipe
Vegan Cheese Popcorn – Nutritional Yeast Popcorn, Dairy Free!
Once you have really good homemade popcorn, you may never go back to the bag in the microwave kind.
My standard blurb about recipes I develop/tweak: I am often hesitant to post recipes because I cook by sight and intuition. I say intuition because it is what I think will appeal to my family's tastes and we have some varied ones let me tell you! Therefore, I do not always use exact measurements. If the recipe doesn't appeal to your taste, it is possible you just need to tweak the amounts of the ingredients.
1-3 Tbs. Nutritional Yeast (I prefer Red Starr brand)
Give the popcorn pot a few shakes every now and then and listen for the pops to start. As they start popping, hold the lid and your pot with your pot holders and give it gentle shakes every now and then to make sure the popcorn doesn't stick to the bottom and burn. Once the popping slows to 2-3 seconds in between each pop, hold the pot off the burner but over it and let it have a few more pops before setting down in a heat safe location. Wait until all popping has stopped for at least 30 seconds. Pour into a big bowl. Heat your oil/butter of choice in the hot pan until melted. Pour it over the popcorn, add your salt if using, the nutritional yeast and toss to coat. Enjoy while warm and fresh! (A note on nutritional yeast in popcorn. We use a lot less than many recipes call for. I have seen folks add as much as a ½ cup to their popcorn which is just way too much for us. You can play around with it to see how much you like by adding a Tablespoon at a time).
Views: 3327
Tags: Dairy Free, Dairy Free, Vegan, Vegan, Organic, Organic, Healthy, Cheese Popcorn, Healthy, Snack, Cheese Popcorn, Gluten Free, Snack, Kid Friendly, Gluten Free, Kid Friendly, Food, Cooking, Food, Entertainment, Cooking, Entertainment
I created this game to help my daughter learn about animal characteristics, habitats and classifications. The rules are similar to the regular 20 questions: you get 20 questions (this never happens, we either go way under or way over), let your child take a turn to be an animal even if you end up going in circles for an hour because they aren't clear on certain things, and you can only ask yes or no questions.
This has fast become my daughter's favorite game to play and every stinking time we are in the car, she wants to play this game. I say stinking because there are some days that I just do not want to be an animal. LOL Seriously, though, it is fun, it is educational and the possibilities are endless.
You, as the parent/caregiver, go first and be patient. You might have to play this a few times for the child to get a good understanding of it. Here is an example:
Adult: I am animal. Guess Who I Am?
Child: Are you a mammal?
Adult: Yes
Child: Do you walk on two legs or four?
Adult: I can't answer that. It has to be a yes or no question only.
Child: Ok, do you walk on four legs?
Child: Do you live in a forest?
Child: Are you an herbivore? ( Yes, my child asks these kinds of questions though in the beginning she didn't know the meaning of these kinds of words.)
Adult: No.
Child: Are you a carnivore?
Adult: No
Child: Are you an omnivore?
Child: Can you be kept as a common household pet? (another question that has evolved through MANY, MANY games. We decided to limit animals to common household pet (rabbit, dog, cat, mice, snake, fish, basically anything you can get at a pet store or shelter, though I do not condone purchasing pets) and should not be pets (animals that are not "domesticated") This arose because we agreed that foxes, bears, etc. should not be pets but do sometimes end up in human homes.
Child: Do you have a long tail? (as opposed to a short tail like a deer or rabbit) You will come up with your own family's rules as you go along because things will come up that can be seen as relevant such as size of animal. For example, a large animal in our game is anything as big as an elephant or giraffe. A medium animal is anything that is bigger than a cat. A small animal is cat size or smaller.
Child: Are you a wolf?
Adult: Yes!
Views: 2892
Tags: Home school, Animal, Game, Characteristics, Classifications, Science, Fun, kids, children
So we frequently play a version of 20 questions to learn more about animal characteristics. ( It is my daughter's favorite game and there are some days that I feel like another game of animal 20 questions may be my undoing! LOL ) One day, my daughter asked me if insects were cold blooded? My first thought was yes, then I second guessed myself. How much do I truly know about insects? Um, not much. So I turned to google and the short answer is:
Yes, most if not all insects are cold blooded. Want to learn more? Try a google search http://www.google.com/search?sourceid=navclient&ie=UTF-8&rlz=1T4GGLL_enUS348US348&q=are+insects+cold+blooded
Views: 2054
Tags: Insects, cold blooded, homeschool, science
As promised…my Christmas Charades list for kids. These were some I just came up with off the top of my head one day so I am sure there are more that could be added. This was a fun party game at our last Christmas party. I find the best way to ensure this is enjoyable for kids is to help take some of the pressure off of them. Some kids hate charades because they can never come up with actions on the spot that might match the word. Be prepared to have an adult "advisor". Give children a few seconds to think of ideas for each word and then have the adult advisor help if necessary. If the concept is too advanced for the kids in your group to guess, have the advisor help out with clues. In other words, you can bend the rules a little for the younger set. The idea is to have fun and learn team work, not be competitive. Just for the record, all of our party games are played for the fun of it, not for prizes.
Trimming the Tree Santa
Christmas Tree
Wrapping Paper/Presents
12 Days of Christmas
Christmas Cookies
Candy Cane
Hot Chocolate
Little Drummer Boy
The Naughty and Nice List
Views: 18754
Tags: Charades List, children, Christmas, kids, List, Ideas, party games, noncompetetive
Children | Games
Cirrus clouds are feather clouds, very high in the sky where the air is cold. These clouds are made of tiny bits of ice because they are so high. Rain does not fall from these clouds. These clouds may be seen at any time of year. In some places, they appear just before or just after periods of rain, so the sight of cirrus clouds can signal the approach of rain in one or two days, or mark the end of a rainy period and the beginning of clear skies.
Stratus clouds are blanket like clouds that are very wide and usually cover most or all of the sky. The weather is not very sunny when we see these clouds in the sky. Rain or snow may fall for a long time.
Views: 6861
Tags: Teach, Clouds
Here are the step by step instructions to actually getting a Disney Rewards Redemption Card from Chase Disney Rewards Credit Card without losing your sanity or creating some form of damage to your computer system. (If you just want the instructions and not the other helpful tidbits I throw in just skip down to numbered part below). If your rewards dollars are about to expire, this is a good way to make them last just a bit longer. Unfortunately, for many folks, it will not last long enough to get that Disney vacation you had hoped to use it for, but at least you can buy your kids something with it. That is, saying that you can actually get the darn card to you because they don't issue vouchers and such. You have to request it. Folks, I like to think of myself as somewhat computer literate. So when something comes along that is not very straight forward and I have to actually go looking for it, I try to jot it down for others. I have to say that this was one of the most frustrating things I have done recently mainly because there was no step by step instructions on their website.
Despite what it looks like, it is free to order. There isn't a shipping fee either as long as you don't have to rush it to your address.
1. Log in to your Chase Disney Rewards Credit Card
2. Click on "See More Information". This is under the account overview that shows you the balance, payment due, etc.
3. Click on "Manage Disney Rewards". This is on the right hand side of the screen about half way down on this list.
4. You will now see your reward dollar amount. Click on "Redeem Rewards" which is currently showing in green font beside your reward dollar account summary.
5. You will now be taken to a screen that shows you any rewards cards that are already issued or pending. If you have never done this before you should have "no active reward redemption cards at this time".
6. Click on "Order Reward Items" which can be found on the right hand side of your screen.
7. Click "Add to Cart" next for the redemption card product. This is currently listed as item # D1001.
8. You have to add a minimum of 20 rewards dollars to the card before they will ship it the first time. After that, the minimum is 10 dollars to be added at a time. I believe you can call into them and ask them to add it to the existing card rather than get a new one mailed to you, if I read the program correctly.
Views: 2519
Tags: Disney, credit cards
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Family members of Lacks, the donor behind the widely used HeLa cell line, are planning to sue Johns Hopkins University.
Doors and Pores
December 1, 2016|
The awesome architecture of the gateways to the nucleus
December 1, 2016|
The awesome architecture of the gateways to the nucleus
October 1, 2016|
Celebrating 30 years and a resurrection
August 1, 2016|
Some thoughts on going to the Galápagos
May 1, 2016|
Science is messy. So lay it out, warts and all.
April 1, 2016|
Defeating cancer is many times more difficult than planting a flag on our lunar satellite.
March 1, 2016|
Scientists still don't know why animals sleep or how to define the ubiquitous behavior.
November 1, 2015|
The causes and consequences of obesity are more complicated than we thought.
October 1, 2015|
Neurons in new brains and old
September 1, 2015|
Auditory research advances worth shouting about
August 1, 2015|
The animal world is full of clever solutions to bioengineering challenges.


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#1,087 GAIL India
- Market Cap As of May 2016
- $7 Billion
- Industry
- Natural Gas Utilities
- Founded
- 1984
- Country
- India
- Chief Executive Officer
- Bhuwan Tripathi
- Website
- http://www.gail.nic.in
- Employees
- 17,666
- Sales
- Headquarters
- New Delhi
GAIL India on Forbes Lists
- #1,087 Global 2000
- #912 in Sales
- #1,109 in Profit
- #1,618 in Assets
- #1,502 in Market value
GAIL (India) Ltd. engages in the exploration, production, processing, transmission, distribution, and marketing of natural gas. It operates through the following segments: Transmission Services, Natural Gas Trading, Petrochemicals, Liquefied Petroleum Gases (LPG) and Liquid Hydrocarbons, and City Gas. The Transmission Services segment includes natural gas and LPG. The Natural Gas Trading segment provides gas distribution services through its wholly owned subsidiaries. The Petrochemicals segment manufactures and markets polymers polypropylene, linear low density polyethylene, and high density polyethylene from natural gas. The LPG and Liquid Hydrocarbons segment sells gas processing unit products such as LPG, propane, pentane, naphtha, and by-products of polymer plant. The City Gas segment comprises of piped natural and compressed natural gases. The company was founded on August 16, 1984 and is headquartered in New Delhi, India.^ ^ More »
More on Global 2000
China's Largest Companies 2016Shreya Agarwal, Forbes Staff


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Jr Kyushu Hotel Kumamoto
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
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TripAdvisor Reviews Jr Kyushu Hotel Kumamoto
Travel Blogs from Kumamoto
Volcano no go - a Castle will have to do
... a reconstruction of Honmaru Goten Palace with beautifully adorned ceilings and walls.
The bonus with the bus pass is you get a discounted admission to key sites. The admission price was the equivalent of about $4 each for the castle and about $2.50 each for the house. A lot less than you pay for something similar at home.
We then went onto a old feudal lords home that was interesting as it was original, not a ...
Fukuoka City - Hakata area
... Canal City before walking back to our hotel. We were pretty exhausted after a day of walking and shopping so we relaxed for a couple of hours before heading out for dinner. We didn't want to go very far, nor have too large a meal so we found the perfect place right across the street from our hotel - a place called Sukiya where they served simple one bowl meals called gyu-don, beef or pork cooked with vegetables served on top of rice. John had a delicious curry ...
Yanagawa City/ Dazaifu
... for over an hour. Our bottoms were pretty sore from sitting on the wooden seats by the time we disembarked. We arrived in a quaint village and we walked to a restaurant that Haruyo had reserved for us. The specialty of the area is grilled eel - kabayaki. It is served on top of rice flavoured with soy sauce. There was also a soup cooked on individual cookers containing fish, eggs, and vegetables and a few exotic dishes including jelly fish, some kind ...
Day 123 - Mt Aso - an active volcano
... this crater. You got great views to Aso town and we saw this perfect cone shaped little hill which once was also a volcano. It was getting pretty windy and when we walked back down the steps, we were blowing all over the place. I have never known such strong winds. We had our scarves wrapped around our heads and battled our way down. Then we walked on a lower track through all these beautiful flowers. We finally made our ...
Days 121-122 - An incredible ryokan experience
... the traditional futon style. They were very comfy. Day 122 Breakfast this morning was served in a dining room and we had chosen the Japanese style. It was another massive load of food, all little plates. The only thing I refuse to eat at all here is natto. It is fermented soy beans. They look foul, all stringy and glutinous so I can't imagine how it smells. Then it was time to leave this paradise and we got a lift to the bus stop to go to our next fleeting visit to Mt ...


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McLean County Independent News
Too much boom?
Last year, Garrison city officials established guidelines for discharging fireworks. Dates and times are: June 27- July 3 – 9 a.m. to 11 p.m.; July 4 -- 9 a.m. to 1 a.m.; July 5 – 9 a.m. to midnight. Apparently few got the memo.
Posted 7/09/14 (Wed) read more »
Rain showers this past weekend dampened the spirits of those who would have preferred the great outdoors to be sunny and dry.
Posted 7/02/14 (Wed) read more »
Issues, ideas hashed about
While McLean County isn't in the heart of the state's bustling oil economy, it isn't immune from impact.
Posted 7/02/14 (Wed) read more »
Drivers receive pay hike
Bus drivers with the Garrison School District have a new pact for the coming school year.
Posted 6/25/14 (Wed) read more »
Two resign from parks, rec.
While one branch of city government, city council, is gelling and taking shape, the other, the parks & rec. department, became as fluid as ever Tuesday night.
Posted 6/25/14 (Wed) read more »
Territorial Inn open for business
A place to rest your weary head.
Posted 6/19/14 (Thu) read more »
Time to fill city council vacancies
The 2014 Primary Election is history. The list of write-in candidates for Garrison City Council and other municipalities in the county has been released.
Posted 6/18/14 (Wed) read more »
Schools get updates
"Just because previous bond issues have failed doesn't mean improvements can't be made."
Posted 6/18/14 (Wed) read more »
Widen Trooper?
Should Trooper Avenue from N.D. Highway 37 to Main Street be widened? Garrison city officials are giving strong consideration to doing so.
Posted 6/11/14 (Wed) read more »
Olson, Kerzmann advance
The field for who will be the next McLean County sheriff and who will square off for a seat representing District 1 on the Board of McLean County Commissioners is set.
Posted 6/11/14 (Wed) read more »


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Factors that can lead to abuse
- Social isolation
- drug or alcohol abuse
- poor housing
- poverty
- family conflict
- mental illness
- sexualisation of children
- gender inequality
- tolerance of violence
- experience of abuse in childhood
Long-term effects on the child and society
As well as being an upsetting and horrible experience, abuse can have devastating effects on a child's development, on their health physically, mentally and emotionally - as well as their relationships and education.
As the child grows into an adult, their earlier experiences mean they can find it harder to cope with life's stresses.
A lack of coping skills or education may limit their ability to get a job or be a good parent. They may also develop mental illness, a substance dependency, criminal behaviour – or sadly become abusive themselves.
So the experience of abuse as a child can have long-lasting affects into adulthood, leaving our whole society to face the consequences.
But - with the right help - abuse can be prevented and people can recover from abuse and go to on to lead happy and fulfilling lives.
Brains are built on our experiences
The video above explains how experiences in the first years of our lives affect how our brains form. Science tells us that the stress of abuse or neglect can damage the basic structures of a child's developing brain. Without the right help, it can put them at risk of a lifetime of health problems, developmental issues and addiction. It's up to us to make sure that children overcome these stresses and have the nurturing experiences they need for positive development.
How child abuse and neglect affects childhood and beyond
Sexual abuse
A child's brain is damaged by sexual abuse, impairing their ability to cope with emotions and stress. This can develop into serious mental illness in adulthood, leading to self-harm and suicide.
Children more likely to take drugs and alcohol, run away from home or break the law. They also find it difficult to have healthy relationships – even with their own children.
Domestic abuse
Children may suffer from depression, anxiety or emotional and behaviour problems. As they grown up, they are more likely to experience domestic abuse in their own relationships.
Emotional abuse
Young children have problems eating, speaking, expressing feelings or gaining confidence. Over time, they may self-harm, develop eating disorders or other risky behaviour.
Female genital mutilation can cause severe pain and infection to a young girl, and she may go on to have difficulties going to the loo, menstruating, having sex or with fertility.
Physical abuse
Even though their initial injuries heal, they may suffer from brain damage, learning problems or post-traumatic stress, and turn to drug and alcohol abuse or criminal behaviour as adults.
Children may not feel confident enough to make friends or do well in school. In addition to mental health problems, they may also develop violent behaviour later in life.
Child trafficking
Children can feel distressed or alienated from their families and culture. They're less likely to finish education or have healthy social interaction.
Sexual exploitation
They're most likely to feel isolated from family and friends, drop out of school or become teenage parents, so they can struggle with relationships or unemployment as adults.
Child sexual abuse costs the UK £3.2bn a year
Source: Saied-Tessier, A. (2014) Estimating the costs of child sexual abuse in the UK.
Explanation: This is an estimated cost for 2012. It is difficult to calculate exact costs because child sexual abuse can take a number of different forms, and can affect victims in a number of different ways. This calculation is based on costs for health, criminal justice service, services for children and loss of productivity to society.
Over half a million children are abused in the UK each year
Source: NSPCC (2013) How safe are our children? 2013.
Explanation: Our calculation is based on the proportion of children who experienced maltreatment at the hands of their parents/carers.
Radford et al (2011) found that 2.5% of under 11s and 6% of 11-17 year-olds had experienced maltreatment by a parent or carer in the previous year.
Using child population data for 2011, we estimate that 520,000 children were abused by a parent or carer that year.
The right support at the right time can change lives
To help prevent abuse from ruining more childhoods, and our society in turn, it's important that everyone plays their part in making sure childhood is free from abuse.
Good relationships with parents and family, especially in the early years, will make children more resilient and able to cope with stressful experiences.
We also need to make sure public services provide the right support for children and families early on, and improve how we identify and respond to problems.
Making changes in our society's attitudes and beliefs about abuse can help too, such as speaking up when you're worried about child or recognising FGM is child abuse.
Help us fight for these changes by supporting our campaigns.
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Care is a vital part of our child protection system. Most children who go into care may have been abused and neglected, so therapeutic support is needed to help them overcome their experience and rebuild their lives.
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This showed up yesterday morning to my surprise. Blooming quite
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Deal or No Deal? How to Shop for a Clothing Bargain
Super-sales at major department stores can yield deep discounts especially if it's end of season. You can also get creative about the places you buy things and think outside the big-name box — there are serious savings in shopping a bit off the beaten track, in the best possible way, such as vintage stores or designer overstock.
The racks at the front of the stores like T.J. Maxx have become less of bargains over the years, offering full-price merchandise from lesser labels. Move straight on back to the "Clearance" sections and start to sort.
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Pregnant Again? Blac Chyna Sports Suspicious Bump While Stepping Out With Another Man
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Lot 14: Chinese Scroll Painting
Asian Art and Antiques
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Past Lot
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Description: China, scroll painting, abstractly painted, with a large group of small birds pecking on the ground, all of them black, amidst blades of grass, with character signature and red seal, attributed to Qi Bai Shi. Width 14 in., Length 26 in.
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About cws6196
I provide a weather email service for people in MD. I am a storm chaser & Skywarn spotter. For daily weather tidbits follow me on Twitter: @wxmanMD.
By: cws6196, 2:42 PM GMT on August 29, 2010
update Friday morning
Well, it looks like this is all we will see from Earl in Southern and Central MD. He is moving NNE almost parallel to OC right now. All the cloud cover we have is from Earl, and any rain is also from Earl.
Gaston faded away and Fiona is no where near us, so for now, all is quiet as far as our weather is concerned. As today progresses the weather will improve, and then from the weekend into next week it will be nice weather (boring for me).
update Thursday afternoon
All appears to be playing out as forecast, so no real changes to what I have previously stated. Southern MD may see some rain and wind Friday morning, while the rest of Central MD will remain dry. Those in Central MD may have some rain showers later Friday, but these are NOT from Earl, rather, they are from the cold front moving in which has kept Earl out to sea; so if it rains Friday afternoon in Central MD, be thankful for the cold front that is bringing that rain.
Any deviation of Earl's path to the West will change my forecast, but I do not see him deviating, although hurricanes do have a mind of their own. I am still watching Gaston and will focus more on that system once Earl is out of the picture.
update Wednesday night
My previous discussion and forecast appear to be on track. Earl is thus far moving as planned, and the trough from the Great Lakes is also progressing. Granted, it is still early and hurricanes can have a mind of their own, but at this pace it appears MD (minus the coast), will be spared the brunt of Earl.
As I see it, those in Southern MD have a slight chance for strong winds and rain, but to be honest, on it's current path, I don't even see Southern MD feeling the effects. Although water levels will be high, especially at high tide, and waves could be over 3 feet Friday into the afternoon. Those in Central MD will not even know anything is happening.
If there are any drastic changes to this forecast I will let you know, but I am as confident as I can be that this is how it will play out. The next system to watch is Gaston, but that is next week's project (if it is headed our way).
update Tuesday night
Not too much to update tonight. The path and timing is about the same as when I updated you last evening. The word of the evening is: timing. The cold front which is coming from the Great Lakes which will help to move Earl off of the coast, needs to arrive as Earl is in position. If Earl arrives sooner then the front, Earl will have a more Westerly track toward the mainland.
It appears the local NWS has been reading my posts (hehe). Here is their latest post to other meteorologists: "WITH THE CURRENT FORECAST PATH/STRENGTH UPON PASSAGE OFF THE COAST...THE LOWER MD BAY/TIDAL POTOMAC INLET AREA WOULD BE THE MOST LIKELY AREA TO RECEIVE THE VERY WESTERNMOST EDGE OF ANY ASSOCIATED RAIN BANDS AND/OR GRADIENT WINDS ABOVE 20KT. FOR AREAS WEST OF THE CHESAPEAKE BAY...INCLUDING THE I-95 CORRIDOR TO THE CNTRL APLCNS - LITTLE DIRECT IMPACT IS EXPECTED BASED ON THE CURRENT FORECAST PATH. A SLIGHT DEVIATION IN THE TRACK WOULD BRING THE EFFECTS CLOSER TO INLAND AREAS...MAINLY OVER THE DELMARVA PENINSULA AND JUST EAST OF I-95." Almost exactly what I stated in my last post.
So what does all this mean? As I have been saying, Southern MD and the Eastern shore should see the effects of Earl Friday. This could include heavy rain and strong winds. But, a slight deviation in the path to the West, and Baltimore could see rain as well. More then likely, Central MD will be spared any effects from Earl.
Fiona is not an issue for us at all as she will stay well out to sea. Timing is everything in this forecast. Earl needs to meet up with the front coming from the Great Lakes at just the right time for the front to move Earl further out to sea. If either of these forces changes speed and does not meet up, then Earl will move closer to the coast, giving Southern MD a stronger storm, and Baltimore some rain.
update Monday night
Not all that much to mention at this time. Each update from the National Hurricane Center on Monday shifted Earl further to the West, closer to the Atlantic coast. But, even though they have shifted Earl closer, that does not mean he will make landfall here. Keep in mind that when you look at a tracking map, there is a margin of error of about 200 to 300 miles. Meaning, the eye could pass within a 300 mile radius of the line drawn on the map.
The NHC has placed our area in a 20% chance for tropical storm conditions, while the local NWS is down playing the effects of Earl on our area. How do I see it? At this time, I do not believe we will have a hit from Earl directly, but given how I feel Earl will pass the area, those especially in Southern MD will be effected by tropical storm conditions, while the rest of Central MD may see some rain, light wind and clouds. Of course, the caveat is that this storm is still too far off for any certainty. I will have a better idea come Wednesday afternoon into the evening. Any effects from Earl will be felt in the wee hours of the morning Friday into the afternoon Friday.
But wait ... there's more ... Fiona!! Currently Fiona is forecast to follow a very similar track as that of Earl, although she will be less powerful of a storm. I will be watching her, but am not too confident she will be an issue for us. Any effects from Fiona won't be felt until the end of this weekend into early next week.
update Sunday night
Well, the latest for Earl is somewhat similar to previous data; it looks that Earl will strengthen into a fairly major hurricane. The good news is that I still do not see Earl making landfall along the mid-Atlantic states. But, as this is forecast to be a major hurricane, the effects of Earl will be felt far inland.
As of the latest figures, we in MD have a 10% chance for tropical storm force winds and heavy rain. Winds would be in the upper 30s to the 40s with rain potential measured in multiple inches. Those on the shore of any major body of water which has any connection to the ocean should see a significant rise in the water level, coupled with the high winds creating heavy surf.
We do not yet want to get ahead of ourselves with this storm. What we do know for certain is it will be a strong hurricane. What we know fairly well is it will not make landfall in MD. What we don't know is exactly how far or close to the coast the center of the storm will be. What I am studying is the forecast for what is called an upper level trough to come out of the Great Lakes later in the week. Depending on the strength, timing and actual position of the trough will influence the direction and position of the storm in relation to the coast.
To summarize: we have a 10% chance for tropical storm conditions to impact MD late Thursday into Friday. This would include high winds, much rain, coastal flooding.
I will keep you posted with updates here and the Weather Phone (443-470-9804). If you have any questions or concerns feel free to comment here or leave them on the Weather Phone.
original post Sunday morning
Well, I have been quiet about the tropics because nothing happening in the tropics has had any potential of effecting us here in MD. Until now. TS Earl is out there and strengthening. None of the current model data have Earl necessarily making landfall in MD, but they do bring him close enough to the MD coast where even Baltimore could feel the effects (rain, wind, minor flooding).
In my opinion, given the data I have at the moment, we will not have a direct hit, but will feel the effects.
This is very preliminary and could change. If the track sticks to the schedule, late Thursday into Friday is when we will see the effects. Of course I will be monitoring this and keeping you posted. But right now no need to change any plans; just keep this scenario in mind as something potential.
Updated: 2:05 PM GMT on September 03, 2010
By: cws6196, 6:27 PM GMT on August 16, 2010
The set up is looking good for storms this afternoon. A cold front is pushing through, during the warmest period of the day, which will trigger the storms. The main threat from these storms will be wind. Currently, I think Central MD and Northern Harford / Cecil county will be the greatest threat for the severe storms.
Timing: most of us should see storm activity around 4:00 to 7:00 or so. Storm cells are already popping up in Western MD.
By: cws6196, 3:15 PM GMT on August 02, 2010
Tuesday evening Update
Here is a quick update on the tropics - we are in the clear. It appears Tropical Storm Colin will fizzle out shortly and become a remnant low. The path of this low will be toward the South East coast of the US. There is a chance for this system to re-generate into a tropical storm as it nears the East coast, but even if this were to occur, we in Central MD have nothing to worry about. Those along the coast would see an increase in the surf and possible rip currents, but that should be the extent of it.
I will keep you posted if there are any changes to what I have forecast.
original post
As you know, I do not typically forecast the tropics, just the weather effecting Central and Southern MD. But, the newly formed Tropical Depression 4 bears some watching given the model data. PLEASE NOTE CAREFULLY: I am not at all saying this will hit us, but I am saying we need to keep on eye on it.
There are many factors and dynamics that can change the path of this storm as we are many days out and it is not yet even a tropical storm. I will continue to monitor this for you and will keep you updated.
As for our local weather this week, we can expect the chance for scattered showers and thunderstorms each afternoon (it is Summer time).
Updated: 3:56 AM GMT on August 04, 2010
The views of the author are his/her own and do not necessarily represent the position of The Weather Company or its parent, IBM.
Talkeetna, AK
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