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Cervical Cancer
Cervical cancer is a common type of malignancy accounting for about 6% of all cancers found in women. It is a disease in which cancerous cells develop in the uterine cervix (this is the connecting passage between the uterus and vagina). The human papillomaviruses (HPV) are the principal cause of most cervical cancers. The peak incidence of cervical cancer occurs between the ages of 40 to 55. It is rare before the age of 35, however the incidence of cervical cancer in younger women rose dramatically during the two decades after 1960. Regular Pap smear tests may detect abnormal changes in the cervical tissues, before cancer develops. Symptoms of cervical cancer may include vaginal bleeding after intercourse or bleeding between periods. However, in the early stages of the disease there are often no obvious signs or symptoms, so regular smear tests are important.
Information for Health Professionals / Researchers
Latest Research Publications
Human Papillomavirus (HPV), Vaccination, and Cervical Cancer
Cervical Cancer Screening (including the PAP smear test)
Gynacological Cancers
Information Patients and the Public (22 links)
National Cancer Institute
PDQ summaries are written and frequently updated by editorial boards of experts Further info.
Cancer Research UK
CancerHelp information is examined by both expert and lay reviewers. Content is reviewed every 12 to 18 months. Further info.
Content is peer reviewed and Cancer.Net has an Editorial Board of experts and advocates. Content is reviewed annually or as needed. Further info.
Macmillan Cancer Support
Content is developed by a team of information development nurses and content editors, and reviewed by health professionals. Further info.
NHS Choices
NHS Choices information is quality assured by experts and content is reviewed at least every 2 years. Further info.
National Cervical Cancer Coalition
NCCC,founded in 1996,is a nonprofit organization dedicated to serving women with, or at risk for, cervical cancer and HPV disease. The NCCC has members around the world, and chapters across the U.S. The Website includes extensive resources.
What You Need To Know About Cancer of the Cervix
National Cancer Institute
Detailed booklet about cervical cancer, including symptoms, diagnosis, treatment, and questions to ask the doctor.
Australian Cervical Cancer Foundation
American Cancer Society
Article covering Cervical cancer, causes, symptoms, diagnosis and treatment.
Detailed information, including snippets from interviews with 25 women, who share their experiences on a broad range of topics related to cervical cancer and treatment and side effects.
Patient UK
Detailed article covering many aspects of cervical cancer, causes, tests, diagnosis, screening, and treatments. Includes advertising.
Cervical Cancer - Module 1: Anatomy of the Cervix
NHS / ASKVisualScience
An animated video about the anatomy of the cervix - part of a series of videos about cervical cancer aimed at general practitioners and their patients.
Cervical Cancer - Module 2: HPV replication and cell cycle dysfunction
NHS / ASKVisualScience
An animated video about the HPV virus can disrupt the cell cycle - part of a series of videos about cervical cancer aimed at general practitioners and their patients.
Cervical Cancer - Module 3: Cervical Intraepithelial Neoplasia
NHS / ASKVisualScience
An animated video about how cancer can develop in the cervix - part of a series of videos about cervical cancer aimed at general practitioners and their patients.
Cervical Cancer - Module 4: Invasive Carcinoma
NHS / ASKVisualScience
Foundation for Women's Cancer
Extensive information and FAQs
Cancer Research UK
Statistics for the UK, including incidence, mortality, survival, risk factors and stats related to treatment and symptom relief.
A non-profit organisation founded in 1991 to increase awareness and education, support expanded research and training, and provide knowledge and hope for women diagnosed with cancers specific to them.
A UK charity dedicated to women and their families affected by cervical cancer and cervical abnormalities. The Trust provides information, support, and promotes awareness of the importance of cervical screening.
Patientnetværket for livmoderhalskræft | Patient Network for cervical cancer - Dansk - Translate to English
Information for Health Professionals / Researchers (12 links)
- PubMed search for publications about Cervical Cancer - Limit search to: [Reviews]
PubMed Central search for free-access publications about Cervical Cancer
MeSH term: Uterine Cervical Neoplasms
US National Library of Medicine
PubMed has over 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Constantly updated.
National Cancer Institute
PDQ summaries are written and frequently updated by editorial boards of experts Further info.
Patient UK
PatientUK content is peer reviewed. Content is reviewed by a team led by a Clinical Editor to reflect new or updated guidance and publications. Further info.
NHS Evidence
Regularly updated and reviewed. Further info.
British Society for Colposcopy and Cervical Pathology
The Society, founded in 1972, is a multi-disciplinary forum for the discussion of all matters pertaining to the prevention of cancer of the cervix.
Detailed referenced article by Cecelia Boardman, MD, covering background, presentation, diagnosis, workup and treatment.
Oncolex - Oslo University Hospital (Norway) and MD Andersen (USA)
Detailed reference article covering etiology, histology, staging, metastatic patterns, symptoms, differential diagnoses, prognosis, treatment and follow-up.
Cancer Research UK
Statistics for the UK, including incidence, mortality, survival, risk factors and stats related to treatment and symptom relief.
A non-profit organisation founded in 1991 to increase awareness and education, support expanded research and training, and provide knowledge and hope for women diagnosed with cancers specific to them.
SEER Stat Fact Sheets: Cervix Uteri
SEER, National Cancer Institute
Overview and specific fact sheets on incidence and mortality, survival and stage, lifetime risk, and prevalence.
Society of Gynecologic Oncology
A professional membership organisation encouraging research, providing education, raising standards of practice, advocating for patients and members and collaborating with other domestic and international organizations. US + international members.
Latest Research Publications
This list of publications is regularly updated (Source: PubMed).
Incidence of Hydronephrosis in Cervical Cancer Patients in A Tertiary Hospital Lagog, Nigeria.
Nig Q J Hosp Med. 2015 Jul-Sep; 25(3):171-6 [PubMed] Related Publications
OBJECTIVE: The aim of this study is to evaluate the incidence of hydronephrosis in cervical cancer patients in Lagos University Teaching Hospital (LUTH), Lagos, Nigeria for the period of 3 years (2010-2012).
METHOD: This study is a cross sectional study carried out among cervical cancer patients seeking treatment in the Radiotherapy department of the Lagos University Teaching Hospital (LUTH), between the year 2010 and 2012, to find out the incidence of hydronephrosis using abdominopelvic ultrasonography.
RESULTS: The incidence of hydronephrosis during the 3years period studied was 43.7%. A rise in the incidence of hydronephrosis of 5.4% in 2011 and 13.3% in 2012 was noted. The mean age of the patients was 55.5 years. 122 (56.7%) were grand multiparous and 123 (57.2%) had multiple sexual partners. An increase of 8.3% in 2011 and 9.3% in 2012 was noted in the incidence of cervical cancer cases studied. 107 (49.8%) presented at stages III and IV.
CONCLUSION: Late presentation of patients is still a major challenge affecting treatment outcomes. The presence of hydronephrosis was noticed at staging, during or after treatment, resulting in the need to separate this population from current Stage IIIB classification. The presence of hydronephrosis may or may not be related to the disease and so adequate staging is important.
Cervical cancer: screening, diagnosis and staging.
J BUON. 2016 Mar-Apr; 21(2):320-5 [PubMed] Related Publications
Genetika. 2016; 52(2):255-9 [PubMed] Related Publications
Metastasis of extra-ampullary duodenal adenocarcinoma to the uterine cervix.
Malays J Pathol. 2016; 38(1):45-8 [PubMed] Related Publications
Correlation of p16INK4a immunoexpression and human papillomavirus (HPV) detected by in-situ hybridization in cervical squamous neoplasia.
Malays J Pathol. 2016; 38(1):33-8 [PubMed] Related Publications
Intracellular glutathione level and efflux in human melanoma and cervical cancer cells differing in doxorubicin resistance.
Postepy Hig Med Dosw (Online). 2016; 70:319-28 [PubMed] Related Publications
MATERIALS AND METHODS: The human melanoma (ME18 and ME18/R) and cervical cancer cells (HeLa and KB-V1) were tested in terms of their DOX sensitivity (EZ4U test), GSH level (HPLC) and its efflux (spectrofluorometrically). The effects of inhibition of the GSH-related enzymes γ-glutamylcysteine synthetase (γ-GCS) and glutathione S-transferase (GST) were also evaluated.
RESULTS: Exposure to DOX caused an increase of GSH levels in all tested cells except for HeLa cells. However, depletion of GSH did not have a significant influence on the sensitivity of the cells to DOX. Inhibition of the activity of GST also did not have a major effect on DOX sensitivity, although it caused changes of the GSH content. Our attempts to use the spectrofluorometric method for measurements of GSH efflux were not successful. It could be suggested that in ME18 and HeLa cells treated with DOX, GSH efflux does occur.
DISCUSSION: The obtained results seem to refute the hypothesis of a central role of GSH in DOX resistance of the tested cells. Despite observations of different effects related to GSH, they do not seem to be essential in terms of DOX resistance. The mechanisms underlying DOX resistance are highly cell-specific.
Human Papillomavirus Vaccine - Knowledge and Attitudes among Parents of Children Aged 10-14 Years: a Cross-sectional Study, Tîrgu Mureş, Romania.
Cent Eur J Public Health. 2016; 24(1):29-38 [PubMed] Related Publications
METHODS: We performed a cross-sectional study using a self-administered questionnaire for the parents of pupils in grades 5-8, in three randomly selected secondary schools in Tîrgu Mureş, Romania.
RESULTS: We surveyed 918 parents. Of the respondents, 85.8% have heard of HPV infection. Most reported an average level of knowledge about HPV infection and HPV vaccination. The two main sources of information were specialized healthcare professionals (42.8% for HPV infection, 39.1% for HPV vaccination) and the Internet browsing (42.3% and 42.9%, respectively). Based on current knowledge, only one third of parents would have their child vaccinated against HPV infection. According to most parents surveyed, the main reasons for not wanting to have their child vaccinated is the fear of side effects; the vaccine is new and insufficiently studied; or parents do not know details about the vaccine.
CONCLUSIONS: The parents showed the average level of knowledge about HPV infection and HPV vaccination. The implementation of an effective programme to increase the acceptance rate of HPV vaccination requires educational strategies aimed at involving parents and their children and supported by general practitioners and public health professionals.
Influence of continuous intervention on growth and metastasis of human cervical cancer cells and expression of RNAmiR-574-5p.
J Biol Regul Homeost Agents. 2016 Jan-Mar; 30(1):91-102 [PubMed] Related Publications
Leiomyosarcoma of cervical stump following subtotal hysterectomy: a case report and review of literature.
Eur J Gynaecol Oncol. 2016; 37(1):148-51 [PubMed] Related Publications
CASE PRESENTATION: A 46-year-old female presented with a one-month history of vaginal bleeding. Vaginal and ultrasonography examination revealed a mass in the cervix. The patient underwent radical resection of the cervix, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy. Chemotherapy and radiotherapy was given after the operation. The patient suffered from severe menopausal symptoms and received hormone replacement therapy. She eventually committed suicide.
CONCLUSION: Given the rarity of cases of leiomyosarcoma of cervical stump, its proper treatment remains to be determined. In dealing with benign uterus diseases, we should pay adequate attention in retaining the cervix. If the cervix is retained, patients require appropriate follow-up. The authors hope that this work will benefit the fields of gynecology and oncology.
Squamous cell carcinoma in situ lining the uterine cavity.
Eur J Gynaecol Oncol. 2016; 37(1):135-8 [PubMed] Related Publications
Outcomes of fertility and pregnancy in patients with early-stage cervical cancer after undergoing neoadjuvant chemotherapy.
Eur J Gynaecol Oncol. 2016; 37(1):109-12 [PubMed] Related Publications
MATERIALS AND METHODS: A total of 11 patients from seven hospitals in Beijing with cervical cancer since August 2009 to December 2011, who had undergone fertility- sparing treatments were recruited in this study.
RESULTS: Among the 11 patients, there were nine cases of squamous cell carcinoma, two cases of adenocarcinoma, one case in Stage IA2, and ten cases in Stage IB1 (FIGO, 2009). All of the 11 patients were treated with NACT of one to two cycles before the operations, and then they underwent radical trachelectomy (RT) + retroperitoneal lymphadenectomy. Eleven patients had completed the follow-up (100%) and the mean follow-up was 24.4 months. The outcomes of the oncology and pregnancy are as follows: no patient recurred after fertility-sparing treatments; in seven patients seeking pregnancy after the treatments, three pregnancies occurred in two women.
CONCLUSIONS: NACT+RT, as a fertility-sparing treatment for young women with bulky early-stage cervical cancer and its outcomes in fertility and pregnancy are satisfactory, however its safety needs to be studied further.
G12V Kras mutations in cervical cancer under virtual microscope of molecular dynamics simulations.
Eur J Gynaecol Oncol. 2016; 37(1):69-74 [PubMed] Related Publications
Morphometric differentiation of squamous cell carcinoma and adenocarcinoma of the cervix.
Pol J Pathol. 2015; 66(4):410-3 [PubMed] Related Publications
Total Pelvic Supralevator Exenteration with Ileo-Colic Orthotopic Neobladder for Locoregional Recurrence after Cervical Cancer - A Case Report.
Chirurgia (Bucur). 2016 Jan-Feb; 111(1):80-6 [PubMed] Related Publications
A Contemporary Review of HPV and Penile Cancer.
Oncology (Williston Park). 2016; 30(3):245-9 [PubMed] Related Publications
Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3.
Clin Epigenetics. 2016; 8:29 [PubMed] Free Access to Full Article Related Publications
RESULTS: MethylCap-seq of normal cervices and CIN2/3 revealed 176 differentially methylated regions (DMRs) comprising 164 genes. After verification and validation of the 15 best discriminating genes with methylation-specific PCR (MSP), 9 genes showed significant differential methylation in an independent cohort of normal cervices versus CIN2/3 lesions (p < 0.05). For further diagnostic evaluation, these 9 markers were tested with quantitative MSP (QMSP) in cervical scrapings from 2 cohorts: (1) cervical carcinoma versus healthy controls and (2) patients referred from population-based screening with an abnormal Pap smear in whom also HPV status was determined. Methylation levels of 8/9 genes were significantly higher in carcinoma compared to normal scrapings. For all 8 genes, methylation levels increased with the severity of the underlying histological lesion in scrapings from patients referred with an abnormal Pap smear. In addition, the diagnostic performance was investigated, using these 8 new genes and 4 genes (previously identified by our group: C13ORF18, JAM3, EPB41L3, and TERT). In a triage setting (after a positive Pap smear), sensitivity for CIN2+ of the best combination of genes (C13ORF18/JAM3/ANKRD18CP) (74 %) was comparable to hrHPV testing (79 %), while specificity was significantly higher (76 % versus 42 %, p ≤ 0.05). In addition, in hrHPV-positive scrapings, sensitivity and specificity for CIN2+ of this best-performing combination was comparable to the population referred with abnormal Pap smear.
CONCLUSIONS: We identified new CIN2/3-specific methylation markers using genome-wide DNA methylation analysis. The diagnostic performance of our new methylation panel shows higher specificity, which should result in prevention of unnecessary colposcopies for women referred with abnormal cytology. In addition, these newly found markers might be applied as a triage test in hrHPV-positive women from population-based screening. The next step before implementation in primary screening programs will be validation in population-based cohorts.
A population of 1136 HPV DNA-HR positive women: expression of p16(INK4a)/Ki67 Dual-Stain Cytology and cytological diagnosis. Histological correlations and cytological follow up.
Pathologica. 2015 Sep-Dec; 107(3-4):185-91 [PubMed] Related Publications
METHODS: Our analysis was in consecutive cases of 1136 women aged 25-64 years, asymptomatic, HR-HPV DNA HC2 tested positive in a HPV-screening program, from February to December 2011. All the women had a cervical sample, in the Thin Prep, used for cytological diagnosis and for pI6/Ki67 dual- staining. Histological correlations were 442. We studied the follow-up of two years of 387 cases, especially the biological behaviour of 316 low-grade lesions.
RESULTS: pI6/Ki67 dual-staining increases the VPP CIN2+ and NPV CIN2+, especially in atrophy/dystrophy, in ASC-US and LSIL. In follow-up of 387 cases, 71 CIN2+ and 316 CIN1, 69 CIN2+, after surgical treatment, had a negative follow up; two cases of CIN2 (p16/ki67-) without invasive treatments, had a spontaneous regression. Among the 316 CIN1, progression was observed in 10 women (4 pI6/Ki67 + and 6 pI6/Ki67 -); regression in 260 women (64 p16/Ki67 + and 196 p16/Ki67-); 46 women had a persistent LSIL (9 pI6/Ki67 + and 37 p16/Ki67-). It seems no significant differences in the biological behaviour in relation to the expression of the two biomarkers.
CONCLUSIONS: pI6/Ki67 immunostaining increases sensitivity of cytology in some diagnostic categories. After follow up of two years, a personalized and adequate treatment does not seem still possible. Further studies and trials are required to improve the management of the cervical lesions in HPV-based screening strategies.
Reducing psychological distress in patients undergoing chemotherapy.
Br J Nurs. 2016 Feb 25-Mar 9; 25(4):S25-30 [PubMed] Related Publications
Screening for Chlamydia is acceptable and feasible during Cervical Screening in General Practice.
Ir Med J. 2016; 109(1):326-7 [PubMed] Related Publications
Unmet clinical needs in cervical cancer screening.
MLO Med Lab Obs. 2016; 48(1):8, 10, 14; quiz 15 [PubMed] Related Publications
Outcomes of a Decade of Routine Cervical Screening in a Canadian Adolescent Obstetrics Clinic.
J Obstet Gynaecol Can. 2016; 38(1):51-5 [PubMed] Related Publications
METHODS: We conducted a retrospective cohort study of cervical cancer screening in all pregnant adolescents receiving antenatal care through an obstetrics clinic for adolescents between 2000 and 2010. Clinic attendees had an antenatal and/or postpartum Pap smear, with follow-up according to standard recommendations. Results were recorded together with information on regression, persistence, or progression of abnormal cytology, colposcopy referrals, and cervical biopsies. There is a single regional colposcopy clinic.
RESULTS: At least one Pap smear result was documented in 365 of the 388 patients. Of these 365 smears, 88 had abnormal cytology, 76 (86.4%) of which were reported as atypical cells of undetermined significance/low-grade squamous intraepithelial lesion, 11 (12.5%) high-grade squamous intraepithelial lesion (HSIL), and one atypical glandular cells (1.1%). Follow-up cytology was available for 78 patients. No patient lost to follow-up had subsequent referrals for colposcopic assessment in the region. Overall, cytologic abnormalities regressed in 75 (96.1%), persisted in two (2.6%), and progressed in one patient (1.3%). Twenty-three patients (of 365) required a total of 68 colposcopy visits and 17 biopsies, but ultimately only three loop electrosurgical excision procedures (LEEPs) and one laser vaporization were performed. Only one LEEP in a 20-year-old demonstrated HSIL.
CONCLUSION: This population of pregnant adolescents had a high incidence of low-grade cervical abnormalities with a high rate of regression. Routinely screening these pregnant adolescents resulted in numerous repeat visits, repeat Pap smears, and colposcopy referrals, and led to patient anxiety and systemic costs. Not a single case of cervical cancer was prevented that would not otherwise have been identified by adherence to the new guidelines.
Validation of Serological Antibody Profiles Against Human Papillomavirus Type 16 Antigens as Markers for Early Detection of Cervical Cancer.
Medicine (Baltimore). 2016; 95(6):e2769 [PubMed] Free Access to Full Article Related Publications
Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study.
BMJ. 2016; 352:i276 [PubMed] Free Access to Full Article Related Publications
DESIGN: Nationwide population based cohort study.
SETTING: Cancer and population registries in Sweden.
PARTICIPANTS: 3,054,328 women living in Sweden at any time between 1 January 1980 and 1 July 2011 who had any record of cervical cytological testing at ages 23-59. Of these, 2,899,968 women had normal cytology results at the first screening record. The first recorded abnormal result was atypical glandular cells (AGC) in 14 625, high grade squamous intraepithelial lesion (HSIL) in 65 633, and low grade squamous intraepithelial lesions (LSIL) in 244 168.
MAIN OUTCOME MEASURES: Cumulative incidence of invasive cervical cancer over 15.5 years; proportion of invasive cervical cancer within six months of abnormality (prevalence); crude incidence rates for invasive cervical cancer over 0.5-15.5 years of follow-up; incidence rate ratios compared with women with normal cytology, estimated with Poisson regression adjusted for age and stratified by histopathology of cancer; distribution of clinical assessment within six months after the abnormality.
RESULTS: The prevalence of cervical cancer was 1.4% for women with AGC, which was lower than for women with HSIL (2.5%) but higher than for women with LSIL (0.2%); adenocarcinoma accounted for 73.2% of the prevalent cases associated with AGC. The incidence rate of invasive cervical cancer after AGC was significantly higher than for women with normal results on cytology for up to 15.5 years and higher than HSIL and LSIL for up to 6.5 years. The incidence rate of adenocarcinoma was 61 times higher than for women with normal results on cytology in the first screening round after AGC, and remained nine times higher for up to 15.5 years. Incidence and prevalence of invasive cervical cancer was highest when AGC was found at ages 30-39. Only 54% of women with AGC underwent histology assessment within six months, much less than after HSIL (86%). Among women with histology assessment within six months, the incidence rate of cervical cancer after AGC was significantly higher than that after HSIL for up to 6.5 years.
CONCLUSIONS: AGC found at cervical screening is associated with a high and persistent risk of cervical cancer for up to 15 years, particularly for cervical adenocarcinoma and women with AGC at age 30-39. Compared with the reduction in risk of cancer seen after HSIL management, management of AGC seems to have been suboptimal in preventing cervical cancer. Research to optimise management is needed, and a more aggressive assessment strategy is warranted.
Image Guided Cervical Brachytherapy: 2014 Survey of the American Brachytherapy Society.
Int J Radiat Oncol Biol Phys. 2016; 94(3):598-604 [PubMed] Related Publications
METHODS AND MATERIALS: A 45-question electronic survey on cervical cancer brachytherapy practice patterns was sent to all American Brachytherapy Society members and additional radiation oncologists and physicists based in the United States between January and September 2014. Responses from the 2007 survey and the present survey were compared using the χ(2) test.
RESULTS: There were 370 respondents. Of those, only respondents, not in training, who treat more than 1 cervical cancer patient per year and practice in the United States, were included in the analysis (219). For dose specification to the target (cervix and tumor), 95% always use CT, and 34% always use MRI. However, 46% use point A only for dose specification to the target. There was a lot of variation in parameters used for dose evaluation of target volume and normal tissues. Compared with the 2007 survey, use of MRI has increased from 2% to 34% (P<.0001) for dose specification to the target. Use of volume-based dose delineation to the target has increased from 14% to 52% (P<.0001).
CONCLUSION: Although use of image-based brachytherapy has increased in the United States since the 2007 survey, there is room for further growth, particularly with the use of MRI. This increase may be in part due to educational initiatives. However, there is still significant heterogeneity in brachytherapy practice in the United States, and future efforts should be geared toward standardizing treatment.
Value of Magnetic Resonance Imaging Without or With Applicator in Place for Target Definition in Cervix Cancer Brachytherapy.
Int J Radiat Oncol Biol Phys. 2016; 94(3):588-97 [PubMed] Related Publications
METHODS AND MATERIALS: The CTVHR was contoured in 39 patients with cervical cancer (FIGO stages I-IVA) (1) on CT images based on clinical information (CTVHR-CTClinical) alone; and (2) using an additional MRI before brachytherapy, without the applicator (CTVHR-CTpre-BT MRI). The CT contours were compared with reference contours on MRI with the applicator in place (CTVHR-MRIref). Width, height, thickness, volumes, and topography were analyzed.
RESULTS: The CT-MRIref differences hardly varied in stage I tumors (n=8). In limited-volume stage IIB and IIIB tumors (n=19), CTVHR-CTpre-BT MRI-MRIref volume differences (2.6 cm(3) [IIB], 7.3 cm(3) [IIIB]) were superior to CTVHR-CTClinical-MRIref (11.8 cm(3) [IIB], 22.9 cm(3) [IIIB]), owing to significant improvement of height and width (P<.05). In advanced disease (n=12), improved agreement with MR volume, width, and height was achieved for CTVHR-CTpre-BT MRI. In 5 of 12 cases, MRIref contours were partly missed on CT.
CONCLUSIONS: Pre-BT MRI helps to define CTVHR before BT implantation appropriately, if only CT images with the applicator in place are available for BT planning. Significant improvement is achievable in limited-volume stage IIB and IIIB tumors. In more advanced disease (extensive IIB to IVA), improvement of conformity is possible but may be associated with geographic misses. Limited impact on precision of CTVHR-CT is expected in stage IB tumors.
Cervical Cancer Screening.
Obstet Gynecol. 2016; 127(3):459-67 [PubMed] Related Publications
Aberrant expression profile of translationally controlled tumor protein and tumor-suppressive microRNAs in cervical cancer.
J BUON. 2015 Nov-Dec; 20(6):1504-9 [PubMed] Related Publications
METHODS: In this study, we assessed the expression of translationally controlled tumor protein (TCTP) using immunohistochemistry and Western blot analysis. The expression pattern of miR-143 was also evaluated using Northern blot analysis.
RESULTS: HeLa cells and mice were used for tumor induction. A group of mice injected with HeLa cells and incubated for 6 weeks developed initial tumor, while a different group of mice injected with HeLa cells and incubated for about 10 weeks developed advanced stage cervical cancer. Histological analysis revealed higher proliferation of cells resulting in complex forms of tumor in advanced cervical cancer, whereas cell clustering was not found to be initiated in the initial stage. The results of immunohistochemistry and Western blot analysis indicated less variation in the expression of TCTP, but significant difference was observed in advanced stage. Expression of Bax apoptotic protein was higher in the initial stage of the tumor than in the advanced cervical cancer. Similar pattern of marginal downregulation of miR-143 was observed between control and initial tumor stages, but striking reduction in miR-143 expression was observed in advanced stages of tumor development.
CONCLUSION: The results of this study reveal a new aspect of altered expression of biomarkers in different pathological stages that could help identify novel therapeutic strategies for cervical cancer treatment.
Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration.
J BUON. 2015 Nov-Dec; 20(6):1497-503 [PubMed] Related Publications
METHODS: The expression of MALAT-1 was examined in tissue samples of 30 CC patients and was compared with the adjacent non-cancerous tissues. The relationship between MALAT-1 levels and clinicopathological parameters from the CC patients was analyzed. Cell migration and invasion assays were performed with quantification of the expression levels of MALAT-1 in 4 CC cell lines using RT-PCR.
RESULTS: Our results demonstrate that MALAT-1 is upregulated in CC. We found higher expression of MALAT-1 in all the 4 CC cell lines, especially in SiHa and ME-180 CC cell lines. After analysis of the relationship between MALAT-1 levels and clinicopathological parameters from CC patients, a robust correlation could be obtained between MALAT-1 overexpression with lymph node metastasis, tumor differentiation and clinical stage. Furthermore, the ectopic expression of MALAT-1 increased cell proliferation and contributed directly to invasion and migration.
CONCLUSION: Taken together, this study suggests an indispensible role played by MALAT-1 in CC progression, which may act as a potential prognostic indicator for CC and also could be a novel potential target for diagnosis of CC.
Inhibitory effect of Aphidicolin - a tetracyclic diterpene - on the proliferation and apoptotic induction in human cervical cancer (HeLa) cells.
J BUON. 2015 Nov-Dec; 20(6):1480-6 [PubMed] Related Publications
METHODS: Flow cytometry was performed to detect alterations in the mitochondrial membrane potential loss (ΔΨm) after aphidicolin treatment. Cell viability was assessed by the MTT assay while the apoptotic effects of the compound were examined by fluorescence microscopy and flow cytometry.
RESULTS: Aphidicolin induced dose-dependent as well as time-dependent cytotoxic effects in HeLa cells. Chromatin condensation and formation of apoptotic bodies were observed by Hoechst 33258 staining after drug treatment. Aphidicolin induced both early and late apoptosis in HeLa cells which were correlated with strong concentration of the compound. ΔΨm was also observed following aphidicolin treatment at varying doses.
CONCLUSION: Aphidicolin is a potent antitumor and apoptotic agent against human cervical carcinoma and its effects are mediated via chromatin condensation and mitochondrial membrane potential loss.
Role of Surgical Versus Clinical Staging in Chemoradiated FIGO Stage IIB-IVA Cervical Cancer Patients-Acute Toxicity and Treatment Quality of the Uterus-11 Multicenter Phase III Intergroup Trial of the German Radiation Oncology Group and the Gynecologic Cancer Group.
Int J Radiat Oncol Biol Phys. 2016; 94(2):243-53 [PubMed] Related Publications
METHODS AND MATERIALS: A total of 255 patients with carcinoma of the uterine cervix (International Federation of Gynecology and Obstetrics stage IIB-IVA) were randomized to either surgical staging followed by CRT (arm A) or clinical staging followed by CRT (arm B). Patients with para-aortic metastases underwent extended field radiation therapy (RT). Brachytherapy was mandatory. The present report presents the acute therapy-related toxicities stratified by treatment arm and radiation technique.
RESULTS: A total of 240 patients were eligible (n=121 in arm A; n=119 in arm B). Of the 240 patients, 236 (98.3%) underwent external beam RT with a median total dose of 50.4 Gy. The mean treatment duration was 53 days. Of the patients, 60% underwent intensity modulated RT (IMRT). A total of 234 patients (97.5%) underwent chemotherapy, and 231 (96.3%) underwent brachytherapy, with a median single dose of 6 Gy covering the tumor to a median nominal total dose of 28 Gy. Treatment was well tolerated, with 0% grade ≥3 genitourinary and gastrointestinal toxicity, 6% grade 3 nausea, 3% grade 3 vomiting, and <2% grade 3 diarrhea. More patients after surgical staging experienced grade 2 anemia (54.3% in arm A vs 45.3% in arm B; P=.074) and grade 2 leukocytopenia (41.4% vs 31.6%; P=.56). Of the patients who received IMRT versus a 3-dimensional technique, 65.3% versus 33.7% presented with grade 2 anemia. Grade 3 gastrointestinal and grade 2 bladder toxicity were significantly reduced with the use of IMRT.
CONCLUSIONS: The incidence and severity of acute therapy-related toxicity compared favorably with those from other randomized trials. Excellent adherence to treatment and treatment quality was achieved compared with patterns of care analyses. Surgical staging led to a doubled number of patients treated with extended field RT. The question of whether surgical staging is beneficial in the context of primary CRT requires further study.


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Daniel Myers
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Vanilla Ice Cream
|2 Cup (32 tbs)
|3⁄4 Cup (12 tbs)
|4 Teaspoon
|1⁄2 Teaspoon
|Egg yolks/2 whole eggs
|Vanilla extract
|2 Teaspoon
|Light cream
|2 Cup (32 tbs)
1. Scald the milk in the top of a double boiler.
2. Mix the sugar, flour and salt. Add the hot milk, stirring, and return to the double boiler. Stir over boiling water until thickened.
3. Beat the egg yolks or whole eggs and add a small portion of the hot mixture. Return to the remaining hot mixture and cook, stirring occasionally, until the mixture coats a metal spoon. Chill thoroughly.
4. Add the vanilla and cream and freeze in a hand-crank or electric freezer.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 416 Calories from Fat 258
% Daily Value*
Total Fat 29 g44.9%
Saturated Fat 17.6 g88%
Trans Fat 0 g
Cholesterol 188.9 mg63%
Sodium 222.6 mg9.3%
Total Carbohydrates 34 g11.4%
Dietary Fiber 0.09 g0.36%
Sugars 29.3 g
Protein 6 g11.4%
Vitamin A 19.9% Vitamin C 0.8%
Calcium 15.1% Iron 2.3%
*Based on a 2000 Calorie diet


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Wylie Dufresne Will Be a Guest Chef at the NoMad Bar for 6 Weeks
Rye pasta, pigs in a blanket, and modernist eggs Benedict will be available at Daniel Humm's restaurant until December.By Alan Sytsma
Rye pasta, pigs in a blanket, and modernist eggs Benedict will be available at Daniel Humm's restaurant until December.By Alan Sytsma
It includes soft-scrambled eggs, a confit egg yolk, homemade cheese, black truffles, bacon, and maple flakes.By Sierra Tishgart
It's harder than ever to make ends meet in New York — and cutting-edge restaurants are adapting their approach as a result.By Alan Sytsma
This is your last chance to eat Wylie Dufresne's beer-cheese burger.By Sierra Tishgart
Come September, the influential chef will be without a restaurant for the first time in 12 years.By Chris Crowley
The 15-minute retrospective honors chef Wylie Dufresne's now-closed restaurant.By Alan Sytsma
It'll be located in a hotel in FiDi.By Sierra Tishgart
It kicks off on April 29.By Alan Sytsma
Wylie's dad is on track to open his long-in-the-works sandwich shop just across the street from the late, great wd~50.By Rob Patronite and Robin Raisfeld
He's launching "Test Kitchen Tuesdays" at Alder.By Sierra Tishgart
Masa chips and pimenton chicharrones are included, naturally. And everything is sold to go.By Rob Patronite and Robin Raisfeld
"Lots of sugar and lots of meat — that is America."By Sierra Tishgart
He grinds shio kombu into the meat.By Sierra Tishgart
The pioneering restaurant lives on.By Hugh Merwin
A look back from David Chang, Daniel Patterson, René Redzepi, and more.By Vicky Gan
Talk about going out with a bang.By Hugh Merwin
Wylie Dufresne's pioneering restaurant is going out with a crazy modernist bang, or course, and not at all with a whimper.By Hugh Merwin
"I've never foraged before. I'm from the Bronx."By Hugh Merwin
Cherche Midi's fries are perfect. Its fancy-ass ketchup is not.By Sierra Tishgart
The chef never strayed from his original plan for the restaurant, even as others suggested he should — and that's exactly why it's so worthy of celebration.By Alan Sytsma
New York's Latest Must-Have Burger May Actually Be Worthy of the Hype
The Absolute Best BYOB Restaurants in New York
Roman Street-Food Sensation Trapizzino Arrives in New York
Boston Officials Threaten to Ban Glassware at Bars After Series of Assaults
Pizza Hut Japan Is Bringing Back Its Store Run Entirely by Cats


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Hotfrog Singapore provides information regarding Reach Media in Singapore. Reach Media is located at 14 Robinson Road Far East Finance Building 13-00, Singapore 048545 and provides Seo services. Contact them on 66531200 or by visiting them on their website http://www.reachmedia.com.sg.
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EAST RUTHERFORD, N.J. -- David Wilson is giving the masses what they want.
After retiring his backflip celebration following the Giants' win over the Saints on Dec. 9, Wilson brought it back Sunday after scoring against the Ravens. Fans and some teammates had been clamoring for the rookie to keep doing his trademark celebration.
"I think it is just me. People liked it so much and then when I said I won't do it ... I heard the complaints," Wilson said. "Then more people approached me after I said I won't go do it, like, 'Man, now come on man!' and even some of my teammates were telling like, 'Man, nah, you got to keep doing that, it gets us excited.' So, uh, I had a change of heart."
There's been a healthy discussion about the backflip, after Wilson did it following each of his three touchdowns in the win over New Orleans. Wilson has been doing it for a long time, so he's comfortable with the maneuver, but teammate Justin Tuck told the rookie to stop. General manager Jerry Reese warned Wilson he'd be upset if the rookie injured himself.
Wilson sees the backflip as a way to bring some energy to the game and have fun. The rookie has rushed 56 times for 283 yards and four touchdowns on the year. He also was named a second alternate to the Pro Bowl as a kickoff returner.
"Without a high energy level and a high enthusiasm, it is hard to play this game and make plays," Wilson said. "That is definitely an aspect you have to have when you are on the field."


text: Stop Driving Teens Everywhere And They'll Get A Licensemichelinemaynard8/06/13 1:16pmFiled to: teensdrivingCurbing Carslicense1151EditPromoteShare to KinjaGo to permalink The University of Michigan talked to 600 young adults about why they haven't gotten their driver's licenses. Some say can't be bothered. Some have other ways to get around. Advertisement The survey shows that the top reason these teens didn't get their license was that they were too busy, or they didn't have enough time. Presumably, that's both for driver's ed, and for the actual time it takes to prepare for the driving test and go to the DMV.Another big group says that owning and maintaining a car is too expensive, and we know that's true. Once you buy a car, you still have to shell out for insurance, gas, parking, and whatever it costs to fix the bumper when you miscalculate getting past the tree next to the driveway. Advertisement But 31 percent said that they didn't get their license because they had someone else to drive that. You've heard about helicopter parents, right? The ones that step in to do everything for their kids?I've heard of parents who don't want their kids to get licenses because the roads are scary. They also don't want them to be distracted from studying to get into Harvard or playing sports. "I'll take you," is probably a phrase heard in every suburban household in America.So: how to get more teens to get licenses? Simple. Insist they carve out the time for driver's ed, grit your teeth, and let them drive once in a while. Allow them to drive on the highway when the traffic isn't too heavy — or what the heck, maybe when it is. That's the best way to learn. You have airbags, after all. Sponsored I'm the first person to say that not everyone likes to drive. I didn't, and while I got my license at 16, I barely drove afterward. I got a ride from my mom, and I rode with friends, and I walked to class.My mom tried to get me interested in driving. She took me out every night after she got home from work, and we drove for about a square mile in our neighborhood. It just didn't take. Advertisement Advertisement But then I got a summer job, in the opposite direction from her office. I had to ride a bus every day for 30 minutes each way. I didn't mind until it got hot, and all my primping efforts were ruined by the time I got to work.The solution came when my mom took a vacation. She left the car keys where I could see them, and said, "If you use a lot of gas, fill up the car."One morning, I just decided I'd drive to work by myself. That did it. Someone trusted me, and I had confidence in myself. I've never had a second thought about driving since then. Advertisement Did your folks drive you places? Are they still doing so? If you don't have a license, what will it take for you to go get one?Reply115 repliesLeave a reply


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The newest fighting game from the Arc Systems, the team behind Guilty Gear and Blaz Blue, is out this week and for most fighting game fans, that's all they need to know. But the game in question, Persona 4: Arena, has a ton of history attached, reaching back as far as the late 1980s and the NES. If you never played Persona before or any of the related Shin Megami Tensei games, or even you have, there's much to learn.
Though the series is known for its density, well take you through the history of Persona and its parent franchise Shin Megami Tensei as delicately as we can. It all started more than 20 years ago in Japan
Shin Megami Tensei begins
It all began on the Japanese version of the NES, the Famicom, with the original Megami Tensei, which in turn was based on a popular novel of the same name. The role-playing game had you playing as a Japanese teen who accidentally releases demons into the world using a computer program. Despite the differences between the diverse collection of SMT sub-series, this intersection of technology and ageless demons is almost always present.
From the start the series stood out from JRPG competition like Final Fantasy, not only because of its modern setting, but also its more PC inspired first-person view. And it was way ahead of the curve with its monster-collecting gameplay. By the time the series adopted its current name of Shin Megami Tensei on the Super Famicom (Japan's Super NES), it had established a healthy cult following in Japan, but publisher Atlus had yet to introduce the series to the West, probably due in some small part to Nintendo's restrictions on demonic imagery. This would eventually change.
Jack Frost and his friends come to America
After dipping its toe in the US market, the first SMT game for North America is a real anomally. Starring two of the cuter SMT monsters, Jack Frost and Pyro Jack, Jack Bros was a more casual adventure that would have been more inviting were it not for the fact that it was on Virtual Boy. The very red 3D portable system was troubled from the start and cancelled quickly, but at least Jack Bros has the dubious distinction of being one of the best VB titles ever.
After Jack Bros, Atlus struggled for several years to find a way to get the series to catch on outside of Japan. Another attempt included their own approach to Pokemon (fitting since SMT blazed the trail in monster collection) in a game that featured Jack Frost and much of the rest of SMTs unique collection of monsters. Called Devil Children in Japan and softened to DemiKids for the US, it still never really caught on, but gradually the series was making a name for itself with perceptive western RPG players.
The first two Personas
Over the next ten years SMT grew in strange ways, introducing spin-offs that covered the fantasy genre as well as Pokemon-influenced games aimed at kids and those set in a Matrix-style digital future. More titles were coming to the US on the PlayStation and PS2, including the third game in the main series, Nocturne. Atlus even gave a chance to the High School set spin-off Persona, though it got off to a rocky start.
The first Persona was localized to remove many of the references to Japanese culture, renaming most of the characters and arcana. This might have made the series more digestible to Americans, but it removed much of the series character, and future releases chose to maintained much of its distinct cultural style. Persona 2 was skipped over initially for US release, perhaps because its plot was even more mature and Japanese than the last games, though both titles eventually got proper localizations when they were recently rereleased on the PSP.
What are Personas?
The Persona series particular approach to Arcana and other occult arts is through Personas, magical versions of someones true self. Whenever these high school students encounter monsters, they battle using these empowered beings that level-up alongside them. Different games in the series call on Personas in different ways, most striking being the third games use of shooting yourself in the head with an Evoker.
Persona 3
Persona 3, with its intense story and very Japanese setting, seemed like a longshot to be released in the US, but Atlus took a chance and RPG players were better off for it. Set in an high-class Tokyo high school, the silent protagonist starts his school year joining SEES, a club that teaches him to enter the monster-filled Dark Hour and summon his Persona to battle the Greater Shadows in hopes of averting catastrophe. Of course all that dungeon exploring has to be balanced with making new friends as the clock keeps on ticking down on the time left in the school year.
Only so much can be done in each day and the year keeps crawling forward, making Persona 3 a compelling combination of RPG adventure, dating sims and time management. It was the story that really earned P3 its accolades, a maturely written tale of sacrifice and redemption that took all the characters through dramatic changes. Many called it the best RPG of the year, if not of all time on the PS2.
Meet the cast
The lead character in P3 is purposefully vague, letting the player define their character through their actions, but his friends are clearly defined. Theres the lively Yukari, the approachable Junpei, the tough Akihiko, and the mature-for-her-age Mitsuru rounding out the SEES team of Shadow hunters, but the biggest fan favorite is likely Aegis. An amnesiac robot that joins the team and learns to be human by experiencing school with them, Aegis was so big she ended up starring in the P3s epilogue The Answer.
Making new friends for XP
If making friends in real life worked like it did in Persona, wed be less antisocial. As introduced by Igor and his remarkably long nose in Persona 3, making bonds with other people opens up new possibilities for your characters and their Personas. Become close enough with the characters, and that includes dating team members of the opposite sex, and youll get bonuses and powers that wont unlock by simple dungeon-grinding. In both 3 and 4, you need to make the most of your high school years, as they may be the best (and last) years of your life.
P3P vs FES
So now youre sold on Persona 3, but whats the best way to play it? The fans are divided on that. The directors cut version of P3 called Persona 3: FES came out a year after the original and tweaked a few things while also expanding the already huge game with a 30 hours of epilogue gameplay. Two years after that Persona 3 Portable aka P3P came to the PSP with more gameplay enhancements and the choice to play as a female protagonist. P3P updated the combat to match the battles in Persona 4, adding in new plots and character cameos, but the anime cutscenes and other extras of the console version had to be cut to fit the game on a UMD.
In our opinion, go with FES, based both its cheap availability on PlayStation Network and the more fully featured presentation, though the appeal of playing P3 on a portable whether the PSP or Vita might be the deciding factor for some of you.
Persona 4
After the darkness of P3, Atlus decided to lighten things up just a little with Persona 4. The high school setting is moved from Tokyo to the more relaxed, rural atmosphere of Inaba, though darkness is starting to creep in along with unnatural and unpredictable fog. The typically silent protagonist is a new transfer student who arrives during the start of a mysterious string of murders that have something to do with his TVs ability to tune into the Midnight Channel, a show that will pull you in if you arent careful.
The hero teams up with his new school chums to explore the Midnight Channel to search for answers to whats corrupting the small town. Persona 4 improved the few flaws that were in P3, deepening the combat and making the social aspects an even bigger deal. The plot also went even more personal with the characters, causing players to form even deeper bonds with the cast.
Meet the cast
The main character began nameless, but spin-offs and side material eventually named him Yu Narukami, though his personality is still left for the player to define. Once he moved to town he quickly befriended the foolish Yosuke and the chipper but violent Chie. Over time the team added the teen detective Naoto, reserved beauty Yukiko, intense, sexually confused Kanji, former idol singer Rise, and the loyal-to-a-fault Teddie. Teddie became the standout of the group, thanks in no small part to the potent mix of his adorable plush outside and the handsome young man inside the suit.
Just me and my Shadow
P4 ditched the faux-suicide Evokers that called on Personas, but what replaced them ended up being even more of an eerie internal struggle. Each team member had to unlock their Persona by defeating their Shadow, a dark reflection of their buried fears and desires. Most became twisted images about what the character hated most about them and once they were overcome and accepted could you gain your Persona. Helping them battle their neuroses made you feel much closer to your teammates, investing players more in an already engrossing plot.
The story continues
Depending on if you put in the time to earn the best ending, Persona 4s more hopeful ending left open the door for a continuation, though most SMT fans were probably surprised to see the story progress in a fighting game. Persona 4 Arena feature most of the playable characters from P4 and several from P3, connecting the two games in clearer ways than previous entries did. P4s hero is returning to Inaba and being drawn back into the Midnight Channel again. This time a fighting tournament is pulling in Persona Users to battle it out, but theres more to it since Arena features one of the deepest stories in any fighter ever. Keep an eye out for the review soon.
Where do you go next?
So youve familiarized yourself with the series and have even played Persona 3 and 4 to prepare for Arena. If you want more SMT goodness, where do you go next wed suggest:
Devil Survivor Overclocked (3DS): An upgrade of the original DS version, Overclocked keeps the SMT tradition of incoming apocalypse, monster-collection and fusion, melding it with a hip teenage cast similar to Personas. Set in modern Tokyo, a group of teens are stranded in the city as angels and demons battle that leave the kids stuck in the middle. A strategy RPG, Devil Survivor puts the fate of the world, Lucifer and God Himself in the players hands. Its hard to get much bigger than that.
Strange Journey (DS): If reading about the unreleased SMT originals piqued your interest for the main series, 2010s Strange Journey for DS is as close as you can currently get. A dark, mature story, first-person perspective and similar focus on demon collection, Strange Journey is proves that traditional gameplay can still be as fun now as it was in the 90s. Search it out before DS games become totally scarce.
Reach out to the truth
We hope this introduction to the series will help you find your true self as well, whether that self likes niche RPGs or not. If we missed anything important, let us know in the comments.
Need Persona? Read Persona 4 Arena roster - An introduction to all 13 fighters to see whos playable in the upcoming game and watch our recent video Quickplay of P4 Arena.


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Now Showing
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Planes: Fire & Rescue 3D
Opens 7/18/2014
Rated PG for action and some peril.
A new comedy-adventure about second chances, featuring a dynamic crew of elite firefighting aircraft devoted to protecting historic Piston Peak National Park from raging wildfire. When world famous air racer Dusty learns that his engine is damaged and he may never race again, he must shift gears and is launched into the world of aerial firefighting. Dusty joins forces with veteran fire and rescue helicopter Blade Ranger and his courageous team, including spirited super scooper Dipper, heavy-lift helicopter Windlifter, ex-military transport Cabbie and a lively bunch of brave all-terrain vehicles known as The Smokejumpers. Together, the fearless team battles a massive wildfire and Dusty learns what it takes to become a true hero.
Find Showtimes & Buy Tickets
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Tag Archives: Rafael Cruz
The Radical Theology That Could Make Religious Freedom a Thing of the Past
Even devout Christians should fear these influential leaders' refusal to separate church and state.
Dominion theology explicitly rejects the United States' venerable separation of church and state, and Dan Patrick and the gang like it that way....Read More
Church and State Stay Cozy at Texas GOP Convention
A Founding Fathers quote you won't find at the #RPT16: religion and government "will both exist in greater purity, the less they are mixed together."...Read More
Ted Cruz's Daddy Issues
Most Texans probably didn't realize that when they elected Ted Cruz to the U.S. Senate, they were getting his dad thrown in at no extra cost....Read More
WTF Friday: God Ordains the Death Penalty!
In this week's WTF Friday, Rafael Cruz consults Genesis on the death penalty, Louie Gohmert takes on Obamacare and Barry Smitherman unveils his anti-poverty pla...Read More
WTF Friday: The Alamo Falls to the U.N.
In this week's WTF Friday, we learn that Hans Blix, Boutrous Boutrous-Ghali and a phalanx of blue-helmeted U.N. troops are going to do what Santa Anna could not...Read More


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If we presume something is amiss, we're going to call the doctor. Some other common troubles are refills which are too soon, drug-drug interactions, and several others. First thing most notable is you have to check if the pharmacy you prefer is genuine. An online generic pharmacy are certain to get its rankings determined with the average from the criteria involved. The Ex - CPT can be an accredited test recognized with the National Community Pharmacists Association (NCPA), the National Organization for Competency Assurance (NOCA), as well as the National Association of Chain Drug Stores.
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On these dates, enjoy reduced admission ($19 adults; $14 seniors and students) and see Fast Forward and Human Interest. Two floors are closed as we prepare for the 2017 Biennial.
The perfect gift for any art enthusiast:Memberships start at just $85.
NARRATOR: Have you ever made something in art class that turned out not as good as you wanted? Look at the bits and pieces inside each of the giant basins. Some of these materials were originally part of other ceramic sculptures, which blew up during the ceramic firing process or came out in a way Sterling Ruby didn't like. He combined all of these mistakes into new works, which he then glazed and fired again and again. What do you think about that? Talk to your adult about a time you tried something that didn't quite work but had an unexpected consequence.


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Sony announces NEX-6 16MP enthusiast mirrorless camera with Wi-Fi
Photokina 2012: Sony has announced the Alpha NEX-6 16MP enthusiast mirrorless interchangeable lens camera and three additional E-mount lenses for its NEX cameras. The NEX-6 builds on the features first seen on the NEX-5R announced last month, including Wi-Fi, in-camera apps and on-sensor phase detection. In addition it gains the high-resolution, 2.3M dot OLED viewfinder previously seen on the NEX-7, plus an external mode dial. In addition, the NEX-6 becomes the first NEX camera to feature the Sony's revived Quick Navi interactive control panel and an ISO-standard hotshoe. The NEX-6 is launched along with a 16-50mm F3.5-5.6 retractable power zoom lens creating a much smaller zoom kit than was previously possible with the NEX system.
Click here to read our NEX-6 hands-on preview, including the 16-50mm F3.5-5.6 power zoom
Jump to:
New Sony α NEX-6 Camera Delivers Full DSLR Experience in Pocket-Sized Package
Compact System Camera Features 16.1 MP APS-C Sensor, Fast Hybrid AF, OLED Viewfinder, Enhanced Control, Expandability and Wi-Fi® Capabilities
SAN DIEGO, Sept 12, 2012 – With a brand new, sleek design and enhanced control capabilities, the new Sony NEX-6 camera packs all the imaging power, shooting responsiveness, handling and operability of a DSLR into a pocket-sized mirrorless camera.
The newest addition to Sony's acclaimed E-mount camera line-up includes Fast Hybrid AF, Wi-Fi capabilities and the Play Memories Camera Apps™ platform recently introduced on Sony's new NEX-5R model, as well as the same high-resolution XGA OLED Tru-Finder™ viewfinder found on the flagship NEX-7 model. Additionally, the NEX-6 adds a standard DSLR-style mode dial for fast, simple navigation between settings.
"Put simply, we are revolutionizing the world of compact system cameras," said Mike Kahn, director of the alpha camera business at Sony Electronics. "With the NEX-6, we've brought a full DSLR experience – fast focus, enhanced control and an "eye-level" shooting style - to consumers at a fraction of the size and weight. Add the convenience of Wi-Fi connectivity and our innovative Play Memories Camera Apps platform, and it becomes a truly compelling product unlike anything else in market today. It's the perfect balance of size, performance quality."
The camera's large Exmor® APS HD CMOS sensor offers 16.1 effective megapixels for true DSLR-quality images and detail-packed Full HD video. It's teamed with a powerful BIONZ® image processor that ensures flawless, low-noise images at extended sensitivity settings up to ISO 25600.
The innovative Fast Hybrid AF system* combines phase- and contrast-detect AF methods. It uses 99 phase-detection AF points arrayed on the image sensor to detect a subject's distance and direction to quickly lock focus on it, and then utilizes contrast-detection AF to confirm extremely fine focus detail. In Speed Priority Continuous shooting mode, the camera automatically switches to phase detection tracking AF to track fast-moving action accurately in each frame at up to 10 frames per second.
As with the flagship NEX-7 camera, the NEX-6 model features an XGA OLED Tru-Finder™ EVF for precision framing and focusing. This 2.36 million dot electronic viewfinder gives a bright, detail-packed, high contrast view of still images and video, with 100% frame coverage and a wide field of view to rival pro-grade optical viewfinders. On-screen grid lines and a digital level gauge can be displayed to assist with accurate framing.
The high-quality OLED Tru-Finder™ EVF is complemented by a 3.0" Xtra Fine LCD™ display that can be angled up to 90° up or 45° down (approx.) for easy viewing in virtually any shooting position. The LCD screen ensures superb detail and contrast with significantly reduced on-screen reflections, aiding composition when shooting outdoors or in direct light.
New for the NEX-6 camera is a strategically-positioned mode dial on its top, similar to those found on traditional DSLR cameras, giving photographers easy access to commonly used shooting modes including P/A/S/M and Sweep Panorama™ mode. The camera also has mode-dependent control dial (located underneath the mode dial) plus a separate control wheel on the camera back for fine adjustments of exposure, ISO, white balance and other settings.
Also inherited from high-end A-mount cameras, a "Function" key and pro-focused Quick Navi interface allows fingertip adjustment of settings without taking the viewfinder away from the shooter's eye. Alongside a handy pop-up flash, there's a versatile new Multi Interface Shoe that's capable of 'intelligent' linkage with various accessories.
Full HD movie shooting is enhanced on the NEX-6 camera with a new Auto Slow Shutter feature that adds extra detail to low-light clips. The camera detects dim interiors and night scenes and automatically selects a slower shutter speed to brighten footage.
Wi-Fi Sharing and New Camera Apps
Shared with the NEX-5R model, integrated Wi-Fi on the NEX-6 camera allows photos to be transferred wirelessly to a smartphone or tablet running Sony's free PlayMemories Mobile™ app (free of charge), available on both Android™ and Apple iOS platforms. Additionally, content can be directly uploaded from the camera to Facebook® using a Wi-Fi connection and the new "Direct Upload" application, part of Sony's new PlayMemories Camera Apps™ platform.
The PlayMemories Camera Apps platform is the world's first application download service in an interchangeable lens camera that allows consumers to install new functions on demand, tailoring their cameras to fit personal shooting needs. The service can be accessed over Wi-Fi or when the camera is connected directly to a PC via USB.**
Available apps at launch, outside of "Direct Upload", will include "Picture Effect+", "Multi Frame NR" and "Smart Remote Control." A variety of other apps including "Bracket Pro", "Photo Retouch", "Time-Lapse" and "Cinematic Photo" are also planned for future release.
New Interchangeable Lenses for α E-mount Cameras
Sony has also introduced three new lenses for its E-mount line of interchangeable lens cameras, adding to the system's flexibility.
The new SELP1650 lens is an extremely light, compact 16-50mm F3.5-5.6 powered zoom model that measures only 29.9 mm thick (when fully retracted) and contains built-in Optical SteadyShot™ image stabilization for clearer handheld images. Additionally, it features a dual-function ring that controls both power zoom and manual focus, depending on the camera's focus mode. With the camera set to AF the control ring adjusts smooth, high-speed zoom with small hand movements. With the camera in MF mode, the ring controls manual focus. A smooth power zoom dial makes the lens particularly useful for shooting video.
The new SEL35F18 lens is a wide aperture 35mm focal length model with a bright maximum aperture of f/1.8 and built-in Optical SteadyShot image stabilization. It offers excellent optical sharpness, clarity, and background defocus in both still images and HD video, and is exceptionally light and easy to carry.
The new SEL1018 lens is a super-wide angle zoom with a maximum aperture of f/4.0 across its range of 10-18mm and built-in Optical SteadyShot image stabilization. Adopting the super ED (Extra-low Dispersion) glass which reduces color aberration, the lens is capable of producing dramatic perspective effects and is ideal for shooting landscapes and interiors.
New accessories for NEX-6
The new stylish, leather LCS-ELC6 Soft Carrying Case is designed exclusively for use with the NEX-6 camera and attached SELP1650 or SEL16F28 lens. While attached, the case still allows use of a tripod as well as the camera's LCD screen to be tilted.
The new LCS-EJA Soft Carrying Case can be used for all α E-mount cameras, and is ideal for use with the new SELP1650 or SEL16F28 lens attached. It has internal pockets for storage of the lens cap as well as a spare memory card.
Pricing and Availability
The NEX-6 compact system camera will be available this November in a kit with the SELP1650 power zoom lens for about $1,000. It will also be offered as body-only for about $850.
The SELP1650 power zoom lens will be sold separately in January for about $350, and the SEL35F18 prime and SEL1018 wide angle lenses will be available this November for about $450 and $850, respectively.
The LCS-ELC6 and LCS-EJA soft carrying cases will be available this November for about $100 and $40, respectively.
The new camera, lenses and all compatible accessories will be available at Sony retail stores (www.store.sony.com) and other authorized dealers nationwide.
Please visit www.blog.sony.com/nex6 for a full video preview of the new NEX-6 compact system camera and follow #SonyNEX on Twitter for the latest α NEX camera news.
Sony Alpha NEX-6 specifications
|$749 (body only), $899 (with 16-50mm lens), $1349 (with 16-50 and 55-210 mm lenses)
|Body type
|Body type
|Rangefinder-style mirrorless
|Max resolution
|4912 x 3264
|Other resolutions
|4912 x 2760, 3568 x 2368, 3568 x 2000, 2448 x 1624, 2448 x 1376
|Image ratio w:h
|3:2, 16:9
|Effective pixels
|16 megapixels
|Sensor photo detectors
|17 megapixels
|Sensor size
|APS-C (23.5 x 15.6 mm)
|Sensor type
|Color space
|sRGB, Adobe RGB
|Color filter array
|Primary color filter
|Auto, 100, 200, 400, 800, 1600, 3200, 6400, 12800, 25600
|White balance presets
|Custom white balance
|Image stabilization
|Uncompressed format
|JPEG quality levels
|Fine, Normal
|File format
|Optics & Focus
|Digital zoom
|Manual focus
|Lens mount
|Sony E
|Focal length multiplier
|Screen / viewfinder
|Articulated LCD
|Screen size
|Screen dots
|Screen type
|Xtra Fine LCD with Tilt Up 90° and Down 45°
|Live view
|Viewfinder type
|Viewfinder coverage
|Viewfinder magnification
|Viewfinder resolution
|Photography features
|Minimum shutter speed
|30 sec
|Maximum shutter speed
|1/4000 sec
|Exposure modes
|Scene modes
|Built-in flash
|Yes (Pop-up)
|Flash range
|6.00 m
|External flash
|Yes (Hot-shoe)
|Flash modes
|Auto, On, Off, Red-Eye, Slow Sync, Rear Curtain, Fill-in
|Flash X sync speed
|1/160 sec
|Continuous drive
|10.0 fps
|Yes (2 or 10 sec, 10sec (3 images))
|Metering modes
|Exposure compensation
|±5 (at 1/3 EV steps)
|AE Bracketing
|(at 1/3 EV steps)
|WB Bracketing
|Videography features
|1920 x 1080 (60, 24 fps), 1440 x 1080 (30 fps), 640 x 480 (30 fps)
|Storage types
|SD/SDHC/SDXC/Memory Stick Pro Duo/ Pro-HG Duo
|USB 2.0 (480 Mbit/sec)
|Yes (Mini Type C)
|Remote control
|Yes (InfraRed (optional))
|Environmentally sealed
|Battery Pack
|Battery description
|Lithium-Ion NP-FW50 rechargeable battery & charger
|Battery Life (CIPA)
|Weight (inc. batteries)
|345 g (0.76 lb / 12.17 oz)
|120 x 67 x 43 mm (4.72 x 2.64 x 1.69″)
|Other features
Additional images
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Discuss in the forums
Nex 7 has been killed, same nice EVF, better lenses performaces especially with old trusted legacy lenses (due to less stressed sensor), better AF system...unless you need printing A2 all the time no reason to buy the 7. Even at same price I'll pick up the 6 for sure.
I still prefer my NEX7, I shoot at low ISOs, mostly landscapes and portraits, I don't need faster AF, I have little need\/want for old legacy glass (I do want some AF). I shoot with a really good copy of the 18-200 OSS and a 50mm OSS and the detail fromthat 24mp sensor is simply amazing. I do make large prints: 16x20, 20x30 and I do crop a bit sometimes - so the extra resolution is better for me. I also like the Tri-navi interface. The NEX6 has some good features, but I'd still buy the NEX7 over it if I had to do it again.
Does this have weather-sealing?
finally sony have gotten rid of that minolta flash shoe, the one thing that kept me from upgrading my r1 and v3
I would be nice, but it´s not probable. As some already pointed out, the reason for releasing RX1 as a fixed lens camera could have been the lack of FF lenses (for CSC). Many people here (including me) have critisized NEXes for lack of lenses, so introducing a completely new body with 1-2 lenses would cause even bigger criticism.
Don't count on it "coming soon." Sony already has the Alpha system to support, including a FF Alpha. And they also have the APS-C NEX system to support. They have to get the market share and sales of *both* these systems up before they can even consider launching a *third* system (a FF MILC system)! I don't think they want to spread themselves too thin by offering three different ILC systems, especially right now when they are trying to get greater market adoption of their two current systems.
This is in my opinion the closest to a perfect CSC. Body as small as M 4/3 cameras, but with an EVF (and the best one, with 2,4M). But this would mean nothing (other NEXes are small too) without ading a perfectly suitable collapsible zoom lens. The biggest disadvantage I critisized on NEX cameras was the disproportion between tiny camera body and big lenses. Nos the power zoom perfectly accompanies small body, making the NEX6 + 16-50 PZ the smallest APCS camera with a zoom lens. Of course physics cannot be cheated, thus we must accept the f3,5-5,6. On the other hand starting at 16 mm is perfect, making the 16 mm pancake obsolete. I am not a Sony fanboy, but I say BRAVO!
What an amazing camera. This or X-E1?
BTW, why is the OLED 1.23M and not 2.36M dot as on X-E1 and NEX-7?
It isn't. Where are you seeing that?
The new NEX-6 + 16-50 kit appears to be very good value.
Have another read... It appears that the NEX-6 does have the 2.3M OLED.....same one as the NEX-7?
@R Butler
The headline paragraph used to say "In addition it gains the high-resolution, 1.23M dot OLED viewfinder previously seen on the NEX-7" It was changed 10 minutes after my post.
@ Steve FStop & abonitas
The kit price is $400 below X-E1's kit price but the Fuji zoom is faster and bound to be better than the pancake zoom.
Also, since I want a fast 35mm eqv. for indoor and night shooting, NEX is actually more expensive as the Zeiss is $1100.
|_F0A5334-Edit_small by Dester Wallaboo
from Open Air Fashion Photography
|Feed me, me, me, me, me by Denjw
from Attention-Seekers in Nature


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By: Sarah Servings: 4-6 Ingredients: 1 lb ground turkey 1 medium red onion, chopped 1 green bell pepper, chopped 4 garlic cloves, chopped 1 tablespoon chili powder 1 tablespoon ground cumin 2 teaspoons unsweetened cocoa powder 1/4 teaspoon ground cinnamon 1 28-ounce can fire-roasted diced tomatoes 2 medium sweet potato, peeled and cut into 1/2-inch… Continue Reading
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Chili Verde
By: Dennis Brunner Servings: 8 Ingredients: 1 1/2 pounds lean beef, cut into 1 inch cubes 1 1/2 pounds lean pork, cut into 1 inch cubes 3 tablespoons coconut oil, maybe a little more 1 large green bell pepper, seeded and chopped 2 large cloves garlic, minced 2 quarts home-canned tomatoes or 2 – 28… Continue Reading
Pumpkin Chili
By: Kathryn Huss Servings: 8 Ingredients: 2 lb. grass-fed ground beef l large onion, chopped l green chili, chopped l 15oz. can pumpkin 1 6oz. can tomato paste l clove garlic, minced 1/2 tsp. cumin 1/2 tsp. cinnamon 1/2 tsp. smoked paprika Salt and pepper to taste Instructions: Brown the ground beef. Add the onion… Continue Reading
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By: Bette Hutchens Servings: 2-3 Ingredients: 2T ground cumin 1T garlic powder 1T onion powder 1T 1t chili powder 1t oregano 1t sea salt 1/2 lb ground beef 3T tomato paste water optional: 3T coconut oil 2 chopped bell peppers 1/4 t cayenne Instructions: Premix dry spices in a bowl. Saute peppers in coconut oil.… Continue Reading
Jole Mole Sweet Potato Chili
By: Brooke Breyfogle Servings: 6-8 Ingredients: 2 tbsp cooking fat of your choice (I use equal parts coconut oil and ghee) 1 cup each of diced onion, celery and carrots (or use Trader Joe's Mirepoix mix!) 2 jalapeño peppers, seeded and finely chopped 4 large cloves garlic, crushed and finely chopped 1 medium red bell… Continue Reading
Lonely Mountain Chuckwagon Chili
By: Mike Dugan Servings: 4 Ingredients: 1 lb. ground beef 2 med. onions chopped 1 cup chopped green pepper 1 can (8 oz.) tomato sauce 1 large can (28 oz.) chopped tomatoes 1 med. sweet potato, sliced and quartered 2 tsps. chili powder 1 tsp. salt 1/8 tsp. cayenne pepper 1/8 tsp. paprika Instructions: Stir… Continue Reading
Spicy White Chicken Chili
By: Suzanne Robertson Servings: 6-8 Ingredients: 2 Tbsp Bacon fat 3 cloves garlic, minced 1 medium brown onion, chopped 2lbs boneless, skinless chicken breasts, cut into 1″ cubes 3 carrots, peeled, halved longways and chopped 4 celery stalks, chopped 1 red bell pepper, chopped 1 green bell pepper, chopped 1 yellow bell pepper, chopped 1… Continue Reading
Chipotle Chili
By: Sean Coonce Servings: 6-8 Ingredients: 2 lbs grass-fed ground beef 1 Tbsp bacon fat 1 large yellow onion, diced 4 cloves garlic, minced 4 stalks celery, chopped 1 bell pepper, diced 1 can diced tomatoes 1 small can tomato paste ¼ C 100% cacao powder see note 2 tsp ground cumin 1 tsp red… Continue Reading
Paleo Chili Deliciousness
By: Lauren S. Servings: 10+ Ingredients: a) 1 large onion chopped b) 2 slices of bacon c) 1 bell pepper chopped (I like yellow) d) 3 garlic cloves minced e) 1 lb ground mild chicken sausage (any sausage will do) f) 1 lb ground turkey or beef g) 2… Continue Reading
Turkey Chili Verde
By: Julie Anderson Servings: 6 Ingredients: ½ lb. Chorizo (pork, turkey or chicken) 3 cups chopped onion 2 TBS chopped garlic 2 TBS chili powder 1 teas cumin salt and freshly ground pepper, to taste 2 cups chicken or turkey stock 6 fresh (or canned if you must) tomatillas finely chopped 1 can… Continue Reading
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Visual Studio Toolbox:Portable Class Libraries
Download this episode
Portable class libraries enable you to write and build managed assemblies that work on more than one .NET Framework platform. You can create classes that contain code you wish to share across many projects, such as shared business logic, and then reference those classes from different types of projects, including those that target .NET Framework 4 and above, Silverlight 4 and above, Windows Phone 7 and above, Windows 8, and XBox 360. In this episode, Daniel Plaisted introduces us to this very exciting technology.
Want more information on portable class libraries? Check out these resources:
- MSDN Portable Class Library Documentation
- MSDN: Using Portable Class Library with Model-View-View Model
- Portable Library Tools for VS2010
- Portable Library Tools blog post with supported feature/platform matrix
- Create a Continuous Client Using Portable Class Libraries
- "Going Deep" Channel 9 Video with David Kean and Mircea Trofin on Portable Libraries
- Reactive Extensions – Towards a Portable Library world
- MEF and TPL Dataflow blog post
- Understanding the Portable Library by Chasing ICommand
- Portable Libraries
- Json.NET – JSON framework
- Autofac – IoC Container
- MvvmCross – MVVM framework for MonoTouch, MonoDroid, Windows Phone, and Windows Metro style
- MVVM Light Toolkit portable fork – Popular MVVM framework
- Portable Class Libraries Contrib – Portable adapters and APIsh
Available formats for this video:
Actual format may change based on video formats available and browser capability.
More episodes in this series
Visual Studio Toolbox: What's New in the Windows Azure June 2012 Release
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Getting Started with MVVM
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Episode 51: Prism the Coolest Framework You're not Using with Brian Lagunas
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The Discussion
Will the code projects be available for download? Or if it is a link above, which one?
The "OnYourWayHome" demo is from David Kean's Create a Continuous Client Using Portable Class Libraries MSDN article. Click on "Download the Code Sample", then on the downloads tab and you will be able to get the source (in both C# and VB). That source code is based on the Beta of VS 2012 and Windows 8 Consumer Preview. If you want to build and run the Metro style app on VS 2012 RC and Windows 8 Release Preview, you will have to make a few updates to that app. (The phone version should work as is.)
The TwitterSearch demo is from the MvvmCross project. Currently, the portable library support is in the vNext branch, so that's where I took it from. I had to make a few changes to get the Metro style app to work on VS 2012 RC.
I've just uploaded source to the Gordian's Knot Puzzle Solver to github.
My handle on twitter is @dsplaisted if you'd like to ask questions there or follow me.
Congratulations on the product, I'm using the demo version with 8 windows and doing tests with parallel programing and I'm loving it.
Many resources for the use of multicore been incorporated into the interfacing, I am now inciando tests with Asp.net and javascript 4 more until this moment I am very satisfied with the product.
Love the XNA Sample..
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Thomas L.
Report | 4 years ago
Will be back for sure.
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Mocha Magic has served up locally roasted coffee and homemade café fare in a sun-bathed modern space since 1994. Behind the café counter, sandwich makers layer sourdough and croissant with honey baked ham, smoked turkey, and fresh produce accompaniments. At breakfast, patrons can jumpstart the day with freshly baked scones and muffins, but are discouraged from jumpstarting a car by pouring espresso drinks directly into the gas tank.


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At Domino's at 1205 E Broad Ave, we offer you the best in pizza delivery and beyond! Our pizza is the best in the business, giving you tons of delicious options and delivering them to you! Meat-lovers and vegetarians alike can find something delicious on the Domino's menu.
And we deliver more than just pizza in your area. When it comes to wings, for example, there's no one like Domino's. Our wings are always baked-to-order and delivered piping hot straight from our ovens.
What can you choose? There's nothing like our delicious chicken wings for a hearty meal. After these savory masterpieces come out of the oven, we cover them with your choice of sauces—or leave them plain! (Just as delicious, we promise) Or mix it up with boneless wings, with light breading and bevvy of spices to complete the perfect bite. Want even more flavor? Get another sauce (or two!) to customize your order. Order any of our saucy treats, from sweet (think Sweet Mango Habanero Sauce) to hot (with our own spicy Buffalo wings sauce) to creamy and cool (reach for Ranch dressing). You can't go wrong! Wing delivery from Domino's is the way to go. We also have meal choices like saucy penne pasta bowls and chicken, as well as sides like salads, drinks, and our stuffed cheesy breads. And don't forget about dessert! Why do we offer so many choices? That's easy: we want you to have the best experience.
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For a tasty experience, turn to Domino's, where deliciousness is done your way every day! From side sauces to your choice of crusts to dozens of toppings, you can get creative and customize your pizza any way you want. And Domino's has more than just pizza! Choices of pasta, sandwiches, breads, chicken, and dessert are all available in the area. Whether you want to order from us near Richmond Community College or you want to place an order near Rohanen Junior High or by Leak Street, Domino's can do it. In Rockingham neighborhood, we're committed to bringing you the very best with special deals and discounts every day. Pick up the phone, go online, or stop by today!
Mon-Thu: 10:30 a.m. to 12 a.m.
Fri-Sat: 10:30 a.m. to 1 a.m.
Sun: 10:30 a.m. to 12 a.m.
(910) 997-4424


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Ships in 1 - 2 Business Days
Product Details
- Material: Cotton
- Replacement wick for our Metal Smudge Pots; sold separately.
- Wick for standard pot is 3-1/2" L.
- Wick for large pot is 4-1/4" L.
- Sold individually.
REVIEW SNAPSHOT®by PowerReviewsReplacement Wick for Metal Smudge Pots
Reviewed by 2 customers
Comments about Replacement Wick for Metal Smudge Pots:
Comments about Replacement Wick for Metal Smudge Pots:
These seem very pricey, but I got an extra for each smudge pot I bought. I cannot vouch for how long they last, but the size is perfect for the smudge pots. Because of the price, I will shop around to see what might be cheaper and possibly can cut my own to save money if I find a cheaper length that is thick enough. These are a perfect fit, however, and I am glad I purchased them. 4 stars is due to price. The quality is excellent.


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Welcome to WebmasterWorld Guest from 18.104.22.168
joined:July 21, 2000
votes: 0
Checking logs, this particular site has not been crawled by anything apart from PFI spiders - so it is not a Freshbot picking it up.
This started on Monday afternoon and I got the last hit last night (but couldn't reproduce the SERPs it came from). Looks like something may be going on, so a word to the wise!
Then suprise suprise this morning I did the same swimming pools search and it has reverted back to Overture/Google.
Then is something going on. But I am going to hold onto my wallet and wait and see what happens.
Using the Overture ppc database and the Inktomi database from Overture. (Although it is not mirroring).
Freeserve could also be using a UK filter on the Inktomi results (even in the �All the Web� search option.) Not sure when or if non UK sites kick in. No sign of Google results.
I think this is a very good move - Freeserve does still send a lot of traffic out around the web - good for Alltheweb too taking a major UK ISP from Google :)
Just wish there were not so many Overture sponsered listing on some searches before you got to the ATW results.
The listings are all served via overture - but I fail to see any similarity between what Overture.co.uk is showing. Neither do I see Google, nor INK, nor ATW. No idea what they are using.
joined:July 21, 2000
votes: 0
The shape of things to come on other ISPs?
Now they are defaulting to All sites and you have to choose the UK radio button to recieve just UK sites.
joined:Mar 8, 2002
votes: 0
Still - our biggest enemy would be inertia in this game.


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Lunch Bar for Sale in Caloundra, Queensland 4551
Mooloolaba QLD - Sunshine Coast
$145,000 + Stock
Restaurant Bar Mooloolaba
Brett Barton 0408 607 344 of Verified Businesses has pleasure in presenting this café / restaurant / bar business for sale on the Sunshine Coast. The res...
RestaurantCafe/Coffee Shop
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Maroochydore QLD - Sunshine Coast
$74,000 + Stock
Perfect First Business For New Owners!
Craig Campbell 0419 747 709 of Verified Businesses, has pleasure in presenting this great entry level Restaurant and Bar, now for sale in Maroochydore!! ...
Craig Campbell


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Robusto #30 · 5.25 × 50 CG303
Bundle of 25
Dominican Republic / Honduras / Nicaragua
Medium - Full
Dark Brown / Maduro
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An excellent value proposition cigar
Pleaseaddascreenname on 04/05/15
Like a lot of people I buy this brand routinely. I prefer the El Ray Del Mundo and Punch but am just too cheap to smoke them regularly. This brand sits at about 85% as good as the above mentioned brands at approximately less than half the cost. So a great deal in my view.
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Don't pass this one up!
Air Balance Rich on 04/19/15
This has become my "go to" cigar. I find it to be an awesome deal and very consistent. I will pull the band and ask me "cigar snob" friends to tell me what they think of my new find. I have got great praise for this wallet friendly stick. Really good on the golf course or the pub.
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Great some when not dry
alawgod on 08/03/15
Flavor profile was enjoyable; spicy and quite good. The only major complaint I have is that the bundle I was sent was dry. The first five sticks had the wrappers crack and disintegrate on me until I realized it was due to poor storage either at the manufacturer's end or J&R's. Once I re hydrated them (thanks YOUTUBE), they were quite pleasant. I would hesitate ordering them again, though.


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by Competitor.com, Published Oct. 8, 2013, Updated Oct. 8, 2013 at 9:22 AM UTC
A running clinic was held for them last weekend.
by Duncan Larkin, Published Jul. 9, 2013, Updated Jul. 9, 2013 at 8:22 AM UTC
His journey since Boston has been anything but easy.
by Duncan Larkin, Published Jan. 18, 2011
His recovery was nothing short of amazing.
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