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Eva Wedding Guide
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x. We use cookies and other similar tools to help you discover what you love about Mary Kay. By continuing to use this site, you consent to the use of cookies on your ...Embracing Change is a fast-paced and funny program that invites viewers to consider their own outlook about change.Celebrate! Change Your Lens, Change Your Life offers a simple yet powerful message: the world is amazing place full of hope, promise, and possibilities.List of free sample resumes, resume templates, resume examples, resume formats and cover letters. Resume writing tips, advice and guides for different jobs and companies.Here is the second half: n ary=n-stufig; n material=n-leitendes Material; n times=differenzierbar|n-mal; n type=n-leitend; nab=erwischen|schnappen; …The Greater Nanuet Chamber of Commerce is dedicated to promoting and supporting the business, civic, and cultural vitality of life in Nanuet through advocacy ...Identidad Corporativa y Soluciones TIC | email@example.com ... Identidad Corporativa y Soluciones TIC | email@example.com signals categorical archives Industrial Design. The Rotolog by Nixon. Grab our blended RSS feed here. Six Colors on the : Apple Watch, and what we know so far.Quando começamos a planejar o sonhado mochilão, seja pela América do Sul ou qualquer outra parte do mundo, algumas perguntas surgem em nossas cabeças.Seeking a Pastor ATTICA-WILLIAMSPORT EVANGELICAL PRESBYTERIAN CHURCH (AWEPC), ATTICA, IN – is seeking a full-time Senior Pastor who will be responsible …
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Tropical Fish Keeping - Aquarium fish care and resources (http://www.tropicalfishkeeping.com/forum.php)
- Catfish (http://www.tropicalfishkeeping.com/catfish/)
- - Pleco wont eat :( (http://www.tropicalfishkeeping.com/catfish/pleco-wont-eat-963/)
Pleco wont eat :(
whenever i toss in the algea tablets my 3 inch pleco wont eat them :(
Hi Taylor.:wave:
What species of plec is that? Some are carnivorous therefore, they may not like greens but rather, meat.
Hope the pleco gang will come to help you soon.:)
Just try to identify your plec first and they'll help you as much as they can. If not, a pic can help.:D
Yeh, i'll go with Blue. Try to get a pic up for an ID so you can find out about the best possible diet for him. In the mean time try some veges like cucumber or zuccini, washed, sliced down the middle & tied to a rock to secure it. Some plecs diet consists almost solely of veges, some eat wood so make sure you have some driftwood in the tank but most sp. will appreciate fresh veges to some degree. Good luck with him.
Or perhaps he has enough to eat already and is not hungry.
(Although I don't think this is true -- plecos are huge pigs.)
hes a common pleco and he never eats :( hes 3-5 inch
Try putting some cucumber or zucchini. They love the veges!!!
Is the pleco in the same tank that has recently been cycled?
How long has the pleco been in the tank? If it's new, it's probably still a bit shy in the tank.
What are the water parameters?
what time of day do you feed him?
a few of mine are really shy, so i feed them when they're most active at night, i also turn the light off.
you can see him with the light from the room to make sure he is eating?
ok this is what i do when i wake up the light has been off all night so i toss in 3 algae tablets and dim the rooms lights to see if hes eating in his caves/place. He ignores them. Then because usually hes at his other cave when the light is on because it ttly enclosed and dark and the other cave isnt i feed him 3 algae tablets there and he ignores them :(
I've never really had this problem with my common pleco. When I first got him he was small and always active now he's about 3-4 inches a little less active but when I throw in an algea wafer/tab he is the first to it...Just kicks the other fish out of the way. The same way when I slice a piece cucumber up and put it in. It takes him a lil while to realize its there but when he does know its there he eats all the way through them! I would definetly slice a pice of cucumber in there and put something threw it so it sinks. Like weights or something, I just use a spoon ( i have nothing else ) and i put the cucumber threw the spoon and then bury the spoon in the gravel so you cant see it....Give it a try!
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More Videos...
Corvette ZR1 angry sound
My Facebook Page - http://tinyurl.com/6385qw2 Blog - http://dtrockstar1.blogspot.com/ Chris Ashworth records the angry sound of a Corvette ZR1, an amazing Exhaust sound. Seen at the Hot Rod Power Tour in Detroit.
2010 Chevrolet Corvette ZR1 | Road Test | Edmunds.com
We roast the tires of the 2010 Chevrolet Corvette ZR1 then explains why the car's new Performance Traction Management system makes it harder to do ... and why that's a good thing. EDMUNDS VIDEO http://www.Edmunds.com is a car-shopping web site driven to make car buying easy. We post at least two videos every week covering the latest cars and trucks with comprehensive reviews, comparisons, and tips & advice from our expert team of automotive editors. Subscribe for the latest Edmunds.com videos: http://tinyurl.com/8dklalg Related Links: Edmunds Price Promise: http://www.edmunds.com/price-promise.html Edmunds Mobile: http://www.edmunds.com/mobile/ Follow Us Twitter: https://twitter.com/Edmunds Facebook: https://www.facebook.com/edmunds Google+: https://plus.google.com/+edmunds/
Corvette ZR1 - Jay Leno's Garage
Corvette ZR1. Although a ZR1 was never part of the original C6 plan, legend has it that at an early review, CEO Rick Wagoner was so impressed that he wondered aloud, "If that's what you can do with $60,000, I wonder what a $100,000 Corvette would look like?" » Subscribe: http://bit.ly/JLGSubscribe » Visit the Official Site: http://bit.ly/JLGOfficialSite THE BEST OF JAY LENO'S GARAGE » Exclusive First Looks: http://bit.ly/JLGExclusives » Ultra Rare Supercars: http://bit.ly/JLGSupercars » Jay's Book Club: http://bit.ly/JLGBookClub JAY LENO'S GARAGE ON SOCIAL Follow Jay: http://Twitter.com/LenosGarage Like Jay: http://Facebook.com/JayLenosGarage ABOUT JAY LENO'S GARAGE A new video every Sunday! Visit Jay Leno's Garage, the Emmy-winning series where Jay Leno gives car reviews, motorcycle reviews, compares cars, and shares his passion and expertise on anything that rolls, explodes, and makes noise. Classic cars, restomods, super cars like the McLaren P1, sports cars like Porsche 918 Spyder and Camaro Z28, cafe racers, vintage cars, and much, much more. Subscribe for more: http://full.sc/JD4OF8 NBC ON SOCIAL: NBC YouTube: http://full.sc/MtLxIM NBC Facebook: http://facebook.com/NBC NBC Twitter: http://twitter.com/NBC NBC Google+: https://plus.google.com/+NBC/posts Corvette ZR1 - Jay Leno's Garage http://youtu.be/-eqtxX3G-7A Jay Leno's Garage http://www.youtube.com/user/jaylenosgarage
Porsche 911 GT2 v Corvette ZR1 - drag race by autocar.co.uk
Which is faster in a one-mile drag race? Porsche 911 GT2 or Corvette ZR1? Visit http://www.autocar.co.uk/porsche/ for the latest Porsche news and reviews, or http://www.autocar.co.uk/chevrolet for the ZR1 reviews. Get the latest car news and reviews at http://www.autocar.co.uk


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"Everybody — every human being — has the obligation to contribute somehow to this world"
—Edith Carter, Holocaust Survivor
Thank you for your interest in career opportunities at the Center for Holocaust and Humanity Education.
Director of Education -The Center for Holocaust and Humanity Education (CHHE) seeks a highly motivated,
knowledgeable, personable, creative and flexible individual with a passion for Holocaust and
tolerance education to serve as the Director of Education in a fast-paced Holocaust education
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For the full job description, please click here..
Qualified candidates can send resumes and references to:
Sarah L. Weiss
Executive Director
8401 Montgomery Rd.
Cincinnati, OH 45236


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Born out of providing strategic consultative services to the Financial Services industry, Sharp Decisions has migrated to many other industry sectors such as Healthcare, Manufacturing, Government and Media & Telecom. For over 25 years, Sharp Decisions has excelled in providing qualified Project Managers, Business Analysts and Subject Matter Experts with experience working with all major software products for our financial services clients throughout the country and around the world
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These are among the reasons why Sharp Decisions is a trusted partner of some of the best-known and most successful Fortune 100 and 500 companies throughout the country and the world.


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Cleveland Summit to Provide 'Point of Intersection' for Materials Engineers, Clinicians and Researchers
Aug 31, 2006, 01:00 ET from ASM International
CLEVELAND, Aug. 31 /PRNewswire/ -- Engineers are problem solvers; clinicians do whatever is necessary to extend and improve life. Put them together and you have the Materials, Medicine and Nanotechnology Summit, held October 2-5 in Cleveland and hosted by the Cleveland Clinic, ASM International and Nano-Network. "The challenges faced in the design of medical implants and devices are frequently materials related," said Shuvo Roy, Co-Director of the BioMEMS Laboratory at the Cleveland Clinic's Lerner Research Institute. "Which material will reduce the possibility of clotting most effectively? Which one will best ensure compatibility with living tissue? How can a smaller implant lead to a less-invasive surgical procedure? Answers to these questions may come from recent advances in materials and nanotechnology." By providing a point of intersection between materials and medicine, the Summit gives biomedical and device designers a way to understand the needs of surgeons and the potential of nanotechnology solutions. "The devices these days need significant input from mechanical engineers, materials people, electronic engineers," said Leonard A.R. Golding, M.D., Director of the Innovative Ventricular Assist System (IVAS) Program at the Cleveland Clinic. "It gets complicated. You need to have your group heading in the same direction." On Tuesday, October 3 through noon on Wednesday, October 4, the Summit will feature Plenary Sessions jointly developed by the Cleveland Clinic and ASM International: Plenary Session I - Orthopedics - Edward Benzel, M.D., Spine Institute, Cleveland Clinic - Dana Medlin, Ph.D., South Dakota School of Mines and Technology Plenary Session II - Cardiovascular - Leonard Golding, M.D., Lerner Research Institute, Cleveland Clinic Plenary Session III - Neurology - Ali Rezai, M.D., Center for Neurological Restoration, Cleveland Clinic - Ramakrishna Venugopalan, Ph.D., Codman and Shurtleff, a J&J Company Plenary Session IV - Nanotechnology - Michael Gertner, M.D., Stanford University - Samuel A. Wickline, M.D., Barnes-Jewish Hospital at Washington University Medical Center - Michael N. Helmus, Ph.D., Advance Nanotech Plenary Session V - Engineered Biomaterials - Tony Calabro, Ph.D., Lerner Research Institute, Cleveland Clinic - Jonathan Baskin, M.D., Case Western Reserve University Plenary Session VI - Minimally Invasive Surgery - Peter Rasmussen, M.D., Neurosurgery, Cleveland Clinic - Sanjay Shrivastava, Ph.D., Abbott Vascular Devices From Wednesday afternoon, October 4 through Thursday, October 5, the Summit will feature two parallel tracks. The Nanomedicine track is focused on biomedical sensors, drug delivery, cellular diagnostics, tissue engineering and clinical opportunities for nanoparticles. The Materials and Processes for Medical Devices track recognizes the role of materials selection and processes in the development of new devices. Keynote Session I -- Biomedical Sensors Unique sensors to fulfill unmet clinical needs in portable and rapid diagnostic and long-term physiological monitoring in vivo. Featured speakers include: - Rashid Bashir, Ph.D., Purdue University - Aaron Fleischman, Ph.D., Lerner Research Institute, Cleveland Clinic Keynote Session II -- Surface Modification and Coatings Surface coatings and finishing techniques to enhance functional properties such as wear, corrosion resistance and enhanced biocompatibility. Featured speakers include: - David Cebon, Ph.D., Granta Design Limited - Donald F. Gibbons, D.Sc., Ph.D., 3M Biosciences Laboratory (Retired) Keynote Session III -- Drug Delivery Innovative devices and strategies for targeted and programmed delivery of therapeutic agents to maximize efficacy. Featured speakers include: - John T. Santini, Jr., Ph.D., MicroCHIPS, Inc. - Tejal Desai, Ph.D., University of California, San Francisco - Pamela B. Davis, M.D., Ph.D., Case Western Reserve University Keynote Session IV -- Nanoparticles/Nanomaterials Fracture, fatigue, corrosion and materials degradation. Featured speakers include: - Thomas J. Webster, Ph.D., Brown University Keynote Session V -- Tissue Engineering Distinctive translational approaches to develop functional tissue and organ replacement. Featured speakers include: - William H. Fissell, M.D., Nephrology, University of Michigan - George Muschler, M.D., Orthopaedic Surgery, Cleveland Clinic - Horst von Recum, Ph.D., Biomedical Engineering Case Western Reserve University Keynote Session VI -- Failure Analysis Fracture, fatigue, corrosion and materials degradation. Keynote Session VII -- Nanoscale Diagnostics Specialized tools to localize and investigate cellular characteristics. Featured speakers include: - Derek Hansford, Ph.D., Ohio State University - Maciej Zborowski, Ph.D., Lerner Research Institute, Cleveland Clinic - Daniel Fletcher, Ph.D., University of California, Berkeley Keynote Session VIII -- Startup to Commercialization From technical innovation to commercial success (what works and what doesn't), process steps for success. Featured speakers include: - Darel Hodgson, Ph.D., Nitinol Technology, Inc. - Michael Lang, BioEnterprise Keynote Session IX -- Nanoparticles In Vivo Identification of clinical opportunities for nanoparticles in tumor detection and treatment. The Summit begins on Monday, October 2, with ASM tutorials on Materials and Processes for Medical Devices. Morning sessions are designed for engineers, while afternoon sessions are designed specifically for clinicians. Topics and presenters include: - Introduction to Polymers for Medical Devices, presented by Richard Lange, Ph.D., The Lubrizol Corporation (Retired) - Basic Metallurgy for Medical Devices, presented by Dana Medlin, Ph.D., South Dakota School of Mines and Technology - Nitinol for Medical Devices, presented by Alan Pelton, Ph.D., Nitinol Devices and Components - Fatigue, Fracture and Corrosion for Medical Devices, presented by Brad James, Ph.D., Exponent Failure Analysis Associates Please visit the conference website at www.nanomedicinesummit.org for registration and exhibitor information. CONTACT: Raquel Santiago Media Relations Cleveland Clinic Foundation firstname.lastname@example.com 216-444-4235 Rego Giovanetti Communications Officer ASM International firstname.lastname@example.com 440-338-5151, x5622 Kelly Coolbaugh Director of Communications NorTech firstname.lastname@example.com 216-241-8458
SOURCE ASM International


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Alvin and the Chipmunks: Chipwrecked [U]20th Century Fox Home Ent. [Blu-ray]
Only 2 in stock
DescriptionThe Chipmunks take to the high seas for this second animated comedy adventure sequel. When their luxury liner becomes grounded on a remote island during a tropical cruise, the Chipmunks soon discover their secluded paradise is not as deserted as it seems. As they struggle to contend with the heat, the insects and the close proximity to one another, the Chipmunks begin to develop a few very strange personality traits.
Mike Mitchell
Disc Features:
Interactive Menus\Enhanced WS tv\Bonus Footage\Other Documentary: 'Going Overboard with the Chipmunks', 'Munking Movies in Paradise', 'Everybody Monk Now - The Making of a Dance-Off Scene', 'Chipmunk Apprentice'
Product Details:
• Certificate: U • Format: Blu-ray • Number of Discs: 2 • Running Time: 87 minutes • Language: English
Create a review
Product Details
- barcode: 5039036050951
- product type: general
- manufacturers product id: 5159107001
- pack size: 2 Discs
Delivery Information
- Saver Delivery: Yes
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Trump, Putin, and the New Cold War
By Evan Osnos, David Remnick, and Joshua Yaffa
What lay behind Russia's interference in the 2016 election—and what lies ahead?
What lay behind Russia's interference in the 2016 election—and what lies ahead?
Led by Cheryl Boone Isaacs, its first black president, the Academy tries to solve its diversity problem.
By running for the D.N.C. chair, the Minnesota congressman hopes to lead a populist opposition against Trump.
At an age when most kids need supervision to do their homework, hundreds of thousands of minors are crossing continents alone.
What the removal of Flynn as the national-security adviser reveals about Donald Trump's White House.
The début of New York's newest train line took place at noon on New Year's Day—ninety-seven years after it was first conceived.
Guided by a lusty appetite for indigenous culture and cuisine, the swaggering chef has become a travelling statesman.
Reflections on two seasons of loss.
Are the city's pumas dangerous predators or celebrity guests?
The complicated moral calculations that followed a horrific crime.


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Media Businesses For Sale in Glasgow DE
Searched the DealStream database for Media Businesses For Sale in Glasgow DE and found no matches. Expanded the search to nearby areas and found the following matches.
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Cherish your travel to the Historic Hungary. Best time to visit
The landlocked country of Central Europe, Hungary, is home to over 10 million people, unfolding its history to travelers during their trip, around the city. The three distinctive climate zones create different weather conditions across the country. But its historic and signatory revelations are rather appealing. Hungary boasts from its restaurant special savories to their legacy of old traditions, from attaining maximum medals at Olympic to hold one of the highest rankings for Noble Laureates. Know the Idyllic weather to visit Hungary Your trip to Hungary can be the most memorable one if you plan your trip well. While summers are warm, it can be sweaty sometimes. Hottest month of Hungary would be in July and August. Hunga… Read More »
Our system every day collects hundreds of travel data about the prices and shows trends on travel market. Check when is the best time for vacation.
People usually expect nice weather while travelling. So, look at forecast, summer and winter temperatures in Budapest XV. kerület


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A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti enhance the sound induced vibration of the basilar membrane, a process known as cochlear amplification (CA). Two questions of broad interest are to be studied;how do the outer hair cells transmit force to activate the CA and what is the mechanical role of the tectorial membrane in CA? Standard techniques are clearly insufficient for answering these questions, so new and innovative methodology will be used. The Fourier Domain Optical (Low) Coherence Tomography (FDOCT) system that we developed gives unique possibilities for studying CA. Using this method;we propose to determine how the complex motion of the organ of the Corti, powered by OHC forces, results in mechanical stimulation of the inner hair cell stereocilia. This is the critical first step in hearing, the stiulation of inner hair cells. We also propose to determine whether the tectorial membrane has a mechanical resonance relevant to organ of Corti function. This is fundamental to understanding how the displacement of the stereocilia hair bundles on outer hair cells can have the proper timing to make effective any force that they actively produce. We also study a controversial question about where along the length of the organ of Corti is OHC power applied to result in traveling wave amplification, sharp tuning, sensitivity and nonlinearity. The distribution of outer hair cell activity is fundamental to knowing how the traveling wave propagates and how otoacoustic emissions are created. The spatial distribution of the CA is studied with FDOCT, innovative optogenetic methodology, and mathematical modeling. We will create a mouse model that has the expression of a light sensitive ion channel in the OHCs. Local and targeted application of light will modulate the CA and reveal it's spatial extent along the length of the cochlear duct.
Normal hearing depends upon the sound amplifying action of sensory outer hair cells in the cochlea while incorrect function or loss of the cells is the cause f the majority of hearing loss. Within the organ of Corti, the cells operate mechanically and electrically to increase the sound caused vibration of the organ. This proposal will learn what the cells mechanically do that results in sensitive and normal hearing.
|Ramamoorthy, Sripriya; Zha, Dingjun; Chen, Fangyi et al. (2014) Filtering of acoustic signals within the hearing organ. J Neurosci 34:9051-8
|Shi, Xiaorui; Zhang, Fei; Urdang, Zachary et al. (2014) Thin and open vessel windows for intra-vital fluorescence imaging of murine cochlear blood flow. Hear Res 313:38-46
|Subhash, Hrebesh M; Choudhury, Niloy; Chen, Fangyi et al. (2013) Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry. J Biomed Opt 18:036003
|Zha, Dingjun; Chen, Fangyi; Ramamoorthy, Sripriya et al. (2012) In vivo outer hair cell length changes expose the active process in the cochlea. PLoS One 7:e32757
|Wang, Ruikang K; Nuttall, Alfred L (2010) Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study. J Biomed Opt 15:056005
|Shi, Xiaorui (2009) Cochlear pericyte responses to acoustic trauma and the involvement of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Am J Pathol 174:1692-704
|de Boer, Egbert; Nuttall, Alfred L (2009) Inverse-solution method for a class of non-classical cochlear models. J Acoust Soc Am 125:2146-54
|de Boer, Egbert; Zheng, Jiefu; Porsov, Edward et al. (2008) Inverted direction of wave propagation (IDWP) in the cochlea. J Acoust Soc Am 123:1513-21
|Zheng, Jiefu; Deo, Niranjan; Zou, Yuan et al. (2007) Chlorpromazine alters cochlear mechanics and amplification: in vivo evidence for a role of stiffness modulation in the organ of corti. J Neurophysiol 97:994-1004
|Chen, Fangyi; Choudhury, Niloy; Zheng, Jiefu et al. (2007) In vivo imaging and low-coherence interferometry of organ of Corti vibration. J Biomed Opt 12:021006
Showing the most recent 10 out of 33 publications


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SARAJEVO (Reuter) - Western countries, unconvinced by promises that aid flights to Sarajevo are safe from rocket attack, have delayed the resumption of a vital humanitarian air bridge to the Bosnian capital.
A UN spokesman in Geneva said yesterday that Germany, Canada and Norway, who are among 19 countries taking part, wanted their planes fitted with electronic anti-missile devices first. Installing the equipment could take until 1 October, the spokesman, Ron Redmond, said. Other countries have not yet replied to an appeal from the office of the UN High Commissioner for Refugees to fly again.
The delay dashed the UNHCR's hopes that the airlift could resume normal operations by mid-week after promises by Muslims, Croats and Serbs that planes would not be attacked. Flights were suspended on 3 September after an Italian aid plane was shot down over Croat and Muslim-held territory near Sarajevo.
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Smooth muscle (SM) cells form the main part of the walls of blood vessels, the airways, the gastrointestinal and reproductive tracts. Pathology of SM contractility plays a key role in hypertension, cerebral and coronary vasospasm, erectile dysfunction, bronchial asthma, and other diseases. SM contractility at a given level of Ca2+ is critically modulated by a complex network of protein-protein interactions, which can enhance the contractile effect acting via a small GTPase RhoA. The design of molecules that would alter these interactions could provide a more specific way of therapeutic targeting of RhoA signaling. It is well understood that RhoA, a ubiquitous molecular switch, is controlled by many different GEFs (guanine nucleotide exchange factors) and GAPs (GTPase activating proteins), which either load RhoA with GTP (GEFs) or downregulate it by catalyzing the hydrolysis of GTP to GDP (GAPs). Which GEFs and which GAPs are active in SM, and how they contribute to the regulation of contractility - is not known. We propose to identify GEFs and GAPs active in SM, and to dissect the mechanisms by which they operate. This is an exciting stage in our ongoing studies of the mechanisms underlying the molecular and structural biology of the RhoA-dependent signaling pathways. Among the GEFs relevant to SM physiology are three RGS RhoGEFs, interacting with the Ga12/13 subunits, for which we have already accumulated a substantial amount of structural information. We present, for the first time, biochemical and functional data implicating p63RhoGEF/GEFT that interacts with Gaq11 linked to specific G-protein-coupled receptors. Promising results of our qRT-PCR experiments identify several GAPs and GEFs new to SM that may down and up regulate RhoA respectively and modulate SM contractility. We also formulate a new hypothesis, supported by preliminary data, which postulates that negative control is exerted on RhoA by cyclic nucleotides (cAMP) acting via the Rap1 GEF, Epac and Rap1 (another GTPase) to activate RhoA specific GAPs including ARAP3 and RA-RhoGAP. We will use a synergistic, multidisciplinary approach that bridges molecular physiology with structural biology. We will study SM tissues from normal and knock-out mice, with an experimental design that allows for the decoupling of the Ca2+-dependent phenomena from RhoA dependent regulation. Using X-ray crystallography, NMR, SAXs and DXMS, we will dissect the molecular mechanism by which the multidomain GEFs and GAPs are regulated in vitro and in vivo. Our research will explain fundamental aspects that control SM contractility and this knowledge may be used to design novel therapies for widespread diseases such as hypertension and asthma.
Diseases like hypertension, coronary and cerebral vasospasm, which compromise blood flow to the heart and brain respectively, as well as asthma which is caused by constriction of the airways, are all caused by abnormal contraction and relaxation of smooth muscle in these tissues. We are studying the role of specific proteins in the regulation of smooth muscle's response to increases in intracellular calcium, which is the primary stimulus for contraction. The results of our research may translate into novel treatments for these diseases.
|Lakshmikanthan, Sribalaji; Zieba, Bartosz J; Ge, Zhi-Dong et al. (2014) Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. Arterioscler Thromb Vasc Biol 34:1486-94
|Derewenda, Urszula; Artamonov, Mykhaylo; Szukalska, Gabriela et al. (2013) Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 A resolution. Acta Crystallogr D Biol Crystallogr 69:266-75
|Utepbergenov, Darkhan; Derewenda, Zygmunt S (2013) The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides. Biochim Biophys Acta 1834:1285-91
|Amin, Ehsan; Dubey, Badri Nath; Zhang, Si-Cai et al. (2013) Rho-kinase: regulation, (dys)function, and inhibition. Biol Chem 394:1399-410
|Artamonov, Mykhaylo; Momotani, Ko; Utepbergenov, Darkhan et al. (2013) The p90 ribosomal S6 kinase (RSK) is a mediator of smooth muscle contractility. PLoS One 8:e58703
|Khromov, Alexander S; Momotani, Ko; Jin, Li et al. (2012) Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle. J Biol Chem 287:20975-85
|Bielnicki, Jakub A; Shkumatov, Alexander V; Derewenda, Urszula et al. (2011) Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF. J Biol Chem 286:35163-75
|Zieba, Bartosz J; Artamonov, Mykhaylo V; Jin, Li et al. (2011) The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. J Biol Chem 286:16681-92
|Momotani, Ko; Artamonov, Mykhaylo V; Utepbergenov, Darkhan et al. (2011) p63RhoGEF couples Gýý(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility. Circ Res 109:993-1002
|Cierpicki, Tomasz; Bielnicki, Jakub; Zheng, Meiying et al. (2009) The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA. Protein Sci 18:2067-79


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From a letter from the Dean Street Block Association, 6th Avenue to Vanderbilt, to Governor David Paterson and President and Chief Operating Officer of the Empire State Development Corporation Avi Schick:
Over the past few weeks we have learned that the schedule for construction of the Atlantic Yards Project is far longer than originally planned, and that there is doubt about whether Phase II of the Project as originally planned will ever reach the construction stage. Despite this news, there is ongoing demolition activity at the project site which may now be wholly unnecessary and which is having and will continue to have a long-term significant impact on the surrounding community. We are writing to ask that you cease all demolition on the site temporarily, and in particular on the footprint of Phase II. Before moving forward there must be a new review of the construction schedule, sequencing, and rationale in light of the changed circumstances.
More on Brownstoner.
Monday, April 07, 2008
Block association calls for a moratorium on AY demolitions
Posted by Norman Oder at 11:11 AM
Labels: AY delays, demolition, Timetable
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It is hypocritical of the press to keep on saying that the supermodels make my generation diet and get eating disorders, then go on to say that Kate Winslet is too fat. What kind of example is it going to set to us? We have enough troubles as it is without people like you making us worry about our weight. The film critics are just feeling sorry for themselves because Kate Winslet didn't win an Oscar.
Aged 15
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Still Forever Royal
The Royals unveiled a new commercial over the weekend. They did the same last year, running a spot during a local break in the Super Bowl. It's strong.
The spot opens with three iconic home runs from last October. First up is the best one, in my opinion: Alex Gordon going over the batter's eye in dead center in Game One of the World Series. That's followed by Alcides Escobar's inside the park job off the leg of Yoenis Cespedes, then Kendrys Morales's we discussed on Thursday in Game Five of the ALDS to put the game out of reach. Kind of funny that a franchise that doesn't hit home runs starts their 2016 marketing campaign with three in a row. Rumor is, they couldn't find any footage of Royals batters taking walks. I kid, I kid. Those home runs were amazing and they all have earned a rightful spot in the pantheon of tremendous Royals at bats.
Then you have Eric Hosmer's slide across home and Drew Butera jumping into Wade Davis's arms. Cut to the parade. Party time.
The spot is decidedly smaller budget than last year's tour of Kansas City with images projected on buildings and landmarks. The only special effect in this spot is the removal of all color except for the blue in a couple of scenes. That is a cool effect and the spot could have used more of it. We've seen this footage thousands of times (if you haven't, what the hell is wrong with you?) so it's OK to desaturate here or there, or to boost the contrast to give it a different feel. The parade is in the spot likely to highlight the connection between the team and the fans, which is definitely the correct call. I still scoff at the estimate of 800,000 people, but that's just picking nits. Whatever the number, say there were a ton downtown for the celebration, and I would nod my head in agreement.
If you get right down to it, the Royals don't have to spend a ton of marketing cash. Ticket sales are probably though the roof and The K is going to be packed all summer. It would've been nice to have a more polished TV spot like last year's, but when you have a drawer full of postseason highlights, that's plenty. It's not a great spot, but it's a good one, and that's all they need.
The only thing missing was a Salvador Perez Gatorade bath. Which is kind of surprising because the billboard the team put up last week at Southwest Trafficway and Westport Road was epic.
All #ForeverRoyal fans deserve a #SalvySplash! Continue our 2015 World Series celebration w/ the biggest splash ever pic.twitter.com/Zj0uD0Qnzw
— Kansas City Royals (@Royals) February 1, 2016
I mean, this is great. Really, really great. The Perez celebratory bath should have it's own hashtag. At this point, it's as much of the Royals as the fountains at The K. Hell, yes. Market around that.
The billboards have become legend the last couple of years. So much so, there's some solid anticipation ahead of the unveiling every winter. This year's entry may be the best of the bunch. If it was possible, I would pour a celebratory bucket of Gatorade on the billboard. How's that for meta?
Overall, I'm much happier the team and their advertising agency brought back the Forever Royal slogan from last year. Whatever works, right? Yet it's more than that. You won't find someone more worn out by the trite and cliched Royals slogans than me. And let's face it, the Royals have had some really, really bad ones over the years. In fact, the slogans are usually easily ignored and forgotten, noticed only when you had a pocket schedule lying around. But there's something about Forever Royal that resonates. There is power in permanence. It reminds everyone the last two years have been about a rebirth of baseball and the Royals in Kansas City and it's something that will always stay with us. This may seem cliche, but this Royals team has brought the city together in ways I don't think anyone believed was possible. I loved the slogan last year. I love it even more today.
It's the perfect slogan for the perfect time.


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Except that they're double the price of the their previous top end cans I think?
I need a couple hundred thousand and a ticket to Japan and some way to get into this next year... Please contribute.
Thanks for the great pics
Wow! Though can't actually be there, still got a taste of this!


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Originally posted on 60 Max Power O | Last updated 11/2/12
by John Huffstetler This debate regarding great collegiate teams and poor NFL teams was rekindled by Steve Spurrier's comments about Alabama possibly being favored against some unnamed NFL teams. For starters, Alabama isn't even that good this year. Last year's Bama squad would beat this year's team, and last year's squad couldn't even beat LSU at home during the regular season (or top 6 points). This year, Bama's "brutal" schedule so far includes wins over Michigan, Miss St., Tennessee, Missouri, Western Kentucky, Florida Atlantic, Ole Miss, and Arkansas. One of those teams is ranked...none are that good. They avoid playing Florida, Georgia, and Spurrier's South Carolina squad out of the East this year out of shear luck. Any of these teams would have a legitimate shot to beat the Tide on a neutral field. Most years, this team isn't even the best in the country, but there simply aren't many good teams this year (that's why average Kansas St. and Notre Dame teams are in the top 5). Beyond the fact that Alabama is assuredly overrated this year, the thought that any college team could beat an NFL team is totally ridiculous. The talent level on any of the 32 NFL teams is much higher than any college team because of the significantly greater number of college squads and the level of maturity and physical development of the players. There are players on 124 FBS teams (pictured to the right) (and some players from other divisions as well) for the NFL to choose from, and they choose the best players. The natural counter argument to this is that Alabama gets the best prospects in the country to choose from; however, the spread is still dramatic. Many players choose a school close to their hometown or because they grew up liking a team. Not every great player just blindly chooses Alabama. There are also hundreds of players every year that go under the radar and earn their way onto an NFL roster through their development and achievement at smaller schools. Here's an all-star squad of players from non-division 1-a schools: QB- Tony Romo- Eastern Illinois (or how about Joe Flacco from Delaware if you prefer)RB- Fred Jackson- Coe CollegeFB- Mike Tolbert- Coastal CarolinaWR- Victor Cruz- UMass (Pictured to the left holding the Super Bowl trophy Vincent Jackson- Northern Colorado Marques Colston- Hofstra Miles Austin- MonmouthOL- Michael Roos- Eastern Washington Willie Colon- Hofstra Jahri Evans- Bloomsburg Dan Connolly- SE Missouri St. Chris Kuper- North DakotaDE- Jared Allen- Idaho St. Robert Mathis- Alabama A&MDT- Stephen Bowen- Hofstra Jacques Cesaire- Southern ConnecticutLB- Akeem Jordan- James Madison London Fletcher- John Carroll Stephen Cooper- MaineCB- Brandon Carr- Grand Valley State (or Dominique Rodgers-Cromartie from Tennessee State if you prefer) Cortland Finnegan- Samford (or Brent Grimes from Shippensburg if you prefer)FS- Nick Collins- Bethune-CookmanSS- Danieal Manning- Abilene ChristianK- Rob Bironas- Georgia SouthernP- Mike Scifres- Western Illinois Alabama wouldn't even beat that team. The point is, the NFL doesn't just take players from the best schools. This is a collection of the best 32 rosters of football players in the country. This list proves that there is talent scattered throughout the country that contributes to NFL rosters at a Pro Bowl level. Not to mention the fact that every player that is drafted into the NFL becomes better as their career progresses for years. Players get smarter and stronger in their mid-to-late 20's than they were from 18-22. To compare the talent level on one NFL team to Alabama, let's take a look at the Kansas City Chiefs and their top players, since they are one of the teams being compared to this Crimson Tide squad, with a particular focus on their stellar collegiate careers: Kansas City Chiefs QB- Brady Quinn- Although largely ineffective on the pro-level (because of the higher talent level in the NFL), Quinn set 36 Notre Dame records during his collegiate career. In 2005, he finished 4th in Heisman voting, while winning the Sammy Baugh trophy as the nation's top QB. In 2006, he won the Johnny Unitas Golden Arm Award and the Maxwell Trophy as the best college football player. He also finished 3rd in Heisman voting. RB- Jamaal Charles- As a true freshman at Texas in 2005, Charles rushed for 878 yards and 11 touchdowns with a 7.4 yards per carry average to help Texas win the National Championship. In his Junior year (his final collegiate year), he rushed for over 1,400 yards, including a 290 yard game against Nebraska. He ranks 4th in Texas history in rush yards (despite skipping his Senior year) behind only Ricky Williams, Earl Campbell, and Cedric Benson. WR- Dwayne Bowe- Bowe started 31 games for LSU (in the precious SEC) where he recorded 154 catches, 2,403 yards, and a school-record 26 TD's. In his senior year, Bowe earned 3rd-team All-American honors and 1st-team All-SEC honors for the top-5 Tiger squad. LB- Derrick Johnson- Johnson was one of the most dominant LB's in the country during his career at Texas. He finished his career with 281 tackles, 10.5 sacks, 9 Int's and 11 Forced Fumbles. He was a first-team Big-12 selection 3 times, first-team All-American twice, and he won the Dick Butkus award as the best linebacker in the country and the Bronco Nagurski award as the best defensive player in the country during his Senior season. SS- Eric Berry- In his three years with Tennessee, Berry racked up 241 tackles (as a cornerback) and had 14 Ints. Considered nationally to be the best shut-down corner in the country, he earned the following accolades: 2-time First-team All-American, 3-time All-SEC, 2007 SEC Defensive Freshman of the year, 2008 Vince Dooley Award, 2008 SEC Defensive Player of the Year, 2008 and 2009 Jack Tatum Award winner, and 2009 Jim Thorpe Award winner. DT- Glenn Dorsey- Although he has struggled to stay healthy and find consistency on the pro-level, Dorsey was one of the most decorated defensive tackles of all-time while at LSU. He was twice named first-team All-SEC and All-American. In 2007, he won SEC defensive player of the year, the Lombardi trophy, the Outland trophy, the Bronco Nagurski trophy, and the Lott trophy while racking up 69 tackles, 12.5 TFL, and 7 sacks for the National Champion Tigers. I could go on as Brandon Flowers (VaTech), Tamba Hali (Penn St.), Javier Arenas (Alabama), Brandon Siler (Florida), Tyson Jackson (LSU), Dexter McCluster (Ole Miss), Steve Breaston (Michigan), and Eric Winston (Miami Fl.) among others had stellar careers for major collegiate football programs. The point is that the Chiefs are LOADED with collegiate football talent. They are essentially a collegiate All-American team unto themselves. Take these collegiate resumes and match them up with the resumes of the current Bama players. It's not even a comparison. This a collection of some of the most decorated collegiate athletes in the country over the past decade...and they're now 1-7 this year. Again, because there are only 32 NFL teams compared to over a hundred college teams, and these are men...not boys. So shut up Steve Spurrier (even though I love you) and others, and show these decorated, accomplished NFL players like the Chiefs some respect. Comparing them to a college team is not only an absolutely ridiculous argument, but it's disrespectful to these teams and players who deserve more respect than to be compared to a group of children who aren't even that good to begin with. I'm instituting a new policy: Anyone who makes the argument that Alabama could beat a pro team can legally be punched in the face without repercussions. I'm flying to South Carolina now to punch Spurrier squarely on his outrageously red cheeks. Please follow us on Twitter @11on11sports Be sure to check out other great articles at 11on11 Sports. var switchTo5x=true; stLight.options({publisher:''});
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They say that Twitter has created a powerful new way for everyone to engage in political dialogue. I'm not so sure it's a good thing. One has only to look at the dysfunctional American political environment, the rise of Donald Trump and the decline of the European Union to see that the inmates take over the asylum.
If our social media profiles can tint in support of Paris, Belgium, and Orlando, then why not change for Turkey, Bangladesh, and Iraq? Innocent lives taken in Turkey airport, and no vigils, or landmarks, but when an attack of similar degree took place in Brussels we did all of the above. I'm often asked why Muslims don't speak out enough, but perhaps this is something we all need to work on.
Is it too much to ask in the 21st century to self-identify based on the beliefs you hold so dearly? After all, who has the right to tell me who I am and who I'm not? Apparently the Pakistani government does, who have declared the Ahmadiyya community "infidel" and non-Muslim since the infamous ruling in 1974.
Like many Canadians, I have struggled to understand the importance of something as seemingly mundane as water. With our Great Lakes and mighty rivers, we're used to seeing water everywhere. I began appreciating how critical water is to survival when visiting the Kurdish region of northern Iraq with World Vision last month.
"Injustice anywhere, is a threat to justice everywhere." These words of Martin Luther King Jr. accurately describe the world crisis we live in today. To avoid war and attacks as such, all nations must come together for the greater good and unite in their efforts to stop all forms of cruelty, persecution and injustice perpetrated in the name of religion or else wise.
"Do good to those who hate you. Bless those who curse you. Pray for those who hurt you." This verse, objectively radical given its relevance today, is particularly applicable in the context of terrorist violence, where strangers are willing to viciously stab, shoot and murder total strangers. One need only think back to the Paris attacks and ask: how can such hatred be justified?
For the past two weeks of school vacation, many Canadian children have enjoyed lingering in bed in the mornings, snuggled under the covers. But for children forced from their homes by violence in Syria and Iraq, warm blankets are more than a holiday luxury. On some mornings, it's just too cold to leave their beds.
The new light in which his decision is inevitably being seen after the despicable acts in Paris makes it important to revisit the issue, which is bigger than the press sometimes lets on. Because Trudeau's decision is not a political one. On the contrary, it is cultural. His decision to stop bombing speaks to what can only be seen as a fulfillment of national identity. Even before Paris, it seemed that nothing in the world could divide Canadians as definitively as their opinion of whether Canada should be dropping bombs in the Middle East.
Like all westerners, I watched in horror at the terror that was unleashed across Paris. But my horror quickly turned to frustration when, immediately in the aftermath, western leaders took advantage of the situation to reinforce a false narrative, and to justify the very policies that have brought us to such a crisis. Our governments do not want us to understand that wittingly or unwittingly (the jury is still out on what role they have really played) they created the conditions for the rise of ISIS, and they did so through exactly the same disastrous policies that they now claim are the only way to destroy it.


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Brian Crower Valves Guides: Exhaust
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BC premium valves guides are made from Manganese Silicon Aluminum Bronze alloy and CNC machined to exacting tolerances. BC guides are resistant to cracking and corrosion, while reducing friction and insures high lubrication even at elevated engine temperatures and rpm's. The perfect replacement to worn or damaged guides and 100% compatible with BC's lineup of stainless steel valves.
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Graham Hollick has just come back from Nepal; he's working on a humanitarian project that encourages women's groups there, and in India, to make money through embroidering textiles. It's obviously a worthy initiative, but a quick glance at his home tells you this must be a cause close to Hollick's aesthetic heart too. He acknowledges the influence on his style, commenting that he "loves India" – a passion reflected in the masks and puppets that stride above his fireplace or adorn his walls.
Yet he also has a magpie-like approach, ever on the lookout – when asked if the framed pairs of Indian masks on the wall are a recent purchase from his travels, he reveals that they hail, in fact, from Camden market: they are taken from a book of children's masks he picked up there one day. And Hollick is as much shaped by the flea-market traditions of France as he is English jumble sales or Asian street markets .
"I lived in Paris for about 10 years so there's a big French flea-market influence," he explains. "Because I do a lot of styling work I'm always picking up things, at flea markets and second-hand shops, and when I'm travelling."
A creative director, Hollick works on diverse projects – from styling catalogues for the likes of The Conran Shop, Laura Ashley and Swarovski, to costume and set design for the theatre company Chicken Shed, to developing a range of high-end Indian fabrics used by fashion houses including Kenzo, Dries van Noten and Georgina von Etzdorf.
Some of the pieces he creates professionally wind up in his own home – that neon "yellow" sign was "something I did for an exhibition for a trade fair years ago". While it might appear at odds with the general rustic vibe, Hollick likes unusual juxtapositions: "I like change – I'll have some things up for only a couple of months and then swap them around. Eclectic would be my inspiration, really."
His travels also allow him to indulge his collector's habit – Hollick now owns quite an army of cheerily painted egg-cups. He has strict rules for his collection, though: they must be wooden, and they must have a face. These restrictions clearly make the acquisition of a new item all the sweeter: "They are quite hard to find but not impossible – I have about 40 or 50 now. The egg cups are something I've been collecting for 15 years."
Hollick is also unafraid to take a hands-on approach in getting his home just how he likes it. He created the distinctive blue shade used on the walls of the hallway: "That kind of Moroccan blue, I mixed myself – I think they call it milk paint, and you add pigment to it, so I did a mix of several different blues."
Hollick lives in Dalston, in north-east London, an area which has become known as the home of hipsters and young creative types. But Hollick is a Dalston old-timer – he's lived there for 14 years and seems a little ambivalent about the recent swarms of people moving to his neighbourhood in the past few years.
"It's changed massively – it was a bit rough round the edges, but it's just had the most incredible transformation," he says. "I've started to feel very old! The whole street is full of young trendy people. You wonder if people think you've moved in with them – but you can't exactly wear a badge saying 'I was here before...'"
- More about:
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UltraTower FreeNAS Build Part 5 Growing the ZPool
This time I swap out 4 of the 250gb drives for 4 2TB drives. I cover the process from beginning to end. Might be a bit long winded, but I didn't miss anything.
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Fillet Of Beef In Red Wine
|Beef fillet
|4 Pound
|1 Teaspoon
|1⁄4 Teaspoon
|Dried rosemary
|1⁄2 Teaspoon
|Bacon slices
|Red table wine
|1⁄2 Cup (8 tbs)
|1⁄4 Cup (4 tbs)
|Fresh mushrooms
|1 Pound
|1 Tablespoon
|Bearnaise Sauce
|4 Tablespoon
Heat oven to 450 degrees.
Trim any excess fat from beef.
Sprinkle with salt, pepper and rosemary.
Tuck thin end under fillet to make it about the same thickness the full length.
Lay bacon slices over meat and tie the fillet with string lengthwise then crosswise as necessary to secure the end you tucked under and the bacon.
Put meat on bottom of shallow roasting pan (not on rack).
Roast in oven 30 minutes, turning once.
Remove from oven.
Reduce oven temperature to 300 degrees.
Remove and discard string and bacon around meat.
Pour wine over and continue roasting (300 degrees) about 30 minutes more, basting often. (This will give you meat that is well browned on the outside and rare in the centre. If you want the meat a little better done, allow about 40 minutes at 300 degrees.)
Heat butter in large heavy skillet when meat is nearly done.
Add mushrooms and cook gently, turning as needed, about 10 minutes or until tender.
Slice meat about 3/4 inch thick and put on hot platter, surround with mushrooms, pour any liquid from pan over and garnish with parsley or watercress.
Serve immediately with Bearnaise Sauce.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 5336 Calories from Fat 3595
% Daily Value*
Total Fat 400 g615.5%
Saturated Fat 168.5 g842.3%
Trans Fat 0 g
Cholesterol 1487.2 mg495.7%
Sodium 3902.3 mg162.6%
Total Carbohydrates 23 g7.7%
Dietary Fiber 6.1 g24.5%
Sugars 7.7 g
Protein 376 g752%
Vitamin A 77.6% Vitamin C 51.7%
Calcium 49.8% Iron 165.1%
*Based on a 2000 Calorie diet


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State Repression and the Labors of Memory
By (author) Elizabeth Jelin
Format: Hardback
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State Repression and the Labors of Memory by Elizabeth Jelin
Book DescriptionHearing the news from South America at the turn of the millennium can be like traveling in time: here are the trials of Pinochet, the searches for "the disappeared" in Argentina, the investigation of the death of former president Goulart in Brazil, the Peace Commission in Uruguay, the Archive of Terror in Paraguay, a Truth Commission in Peru. As societies struggle to come to terms with the past and with the vexing questions posed by ineradicable memories, this wise book offers guidance. Combining a concrete sense of present urgency and a theoretical understanding of social, political, and historical realities, State Repression and the Labors of Memory fashions tools for thinking about and analyzing the presences, silences, and meanings of the past. With unflappable good judgment and fairness, Elizabeth Jelin clarifies the often muddled debates about the nature of memory, the politics of struggles over memories of historical injustice, the relation of historiography to memory, the issue of truth in testimony and traumatic remembrance, the role of women in Latin American attempts to cope with the legacies of military dictatorships, and problems of second-generation memory and its transmission and appropriation. Jelin's work engages European and North American theory in its exploration of the various ways in which conflicts over memory shape individual and collective identities, as well as social and political cleavages. In doing so, her book exposes the enduring consequences of repression for social processes in Latin America, and at the same time enriches our general understanding of the fundamentally conflicted and contingent nature of memory. A timely exploration of the nature ofmemory and its political uses.
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Book DetailsISBN: 9780816642830
(229mm x 148mm x 15mm)
Pages: 163
Imprint: University of Minnesota Press
Publisher: University of Minnesota Press
Publish Date: 19-Nov-2003
Country of Publication: United States
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Waiting around as transferable skill
What was most annoying about labwork was that sometimes there were 14-hour workdays of which only about an hour was actual work, and the rest was just waiting. Waiting for gels to set, waiting for gels to run, waiting for machines to finish, blots to incubate,
paint slides to dry.
Sound familiar?
Well, guess what: this may just be a transferable skill.
"The logs reveal a job which involves long periods of waiting around but which at any moment could require concentration when something finally happens."
Writes BBC news, in an article about a job opening at MI5. The Security Service is hiring new "mobile surveillance officers", and the required skills include both patience and observance.
So if you want to leave science, you can always be a spy!
Like a scientific career, it might not be as glamorous as it sounds, though. The salary starts at £26,250, which is on the low end of the average UK postdoc salary. As the BBC points out, you're better off applying for another job opening at MI5: they're also hiring carpenters who get paid a thousand pounds more per year than the new spies.
But if that doesn't put you off (and why would it? you didn't go into science for the cash either) here's the info, with an interactive game to test your skill. I have no idea what the game is like, because it took several minutes to load, and I didn't want to wait any longer so I closed the window.
I see what just happened.
A metaphor for science and technology
Forget about art and science – this century has a whole new two world problem.
It's been nagging me for a while – at science online conferences (both the London and North Carolina varieties), in talks with lab mates, at work at a scientific publisher, and hanging out with technology-oriented geeks in my spare time. There's a gap between science and technology, and it's growing.
Were we to take some opinions on the street, vox-pop-style, about perceived "two worlds" between science and other fields, I'm sure many would still point to a supposed divide between the arts and sciences. That may be what it seems like – from books and TV, from high school memories – but if you're in art or science, this supposed divide is so well-bridged that you don't even notice the chasm when you cross it.
Yet what none of our hypothetical vox-poppers would say is that there is such a thing as a divide between science and technology. To the contrary, they always see them together. "Science and Technology" share newspaper sections, website pages, and ticky-boxes on "occupation" fields in surveys. Science brought us technology, so surely they go hand in hand?
It's true, they used to go well together, and in certain fields of research they still do, but apart from areas like computer science or bioinformatics, there is no correlation between people who like to use computers, and people who like to do research.
The thing is: scientists are just like normal people. You'll find that a small group of them is hugely interested in blogging, just like a small group of the overall population is. Another (perhaps overlapping) group is over the moon about new web tools they can try out in the lab, just like there's a small group of early adopters in the general population. But by and large, many scientists hate new things.
It is this audience of print-reading, references-in-Word-typing, Facebook-avoiding researchers that we are trying to get to download new reference managers, upload their data for their competitors, and while they're at it, write a blog post or two.
It's scary for me to sit in a seminar that teaches publishers and scientists about social media – things I've picked up on the go, without anyone teaching me – and it's frustrating to see enthusiastic digital natives pitch the next new tool to reluctant researchers. I've seen both. I'm kind of in between the two worlds, and they really are two worlds.
Where art and science have many bridges (a love for high resolution microscopy, excitement about data from outer space, and a common struggle to get funded – to name a few) science and technology have little to go on. They share a past, but they've moved in their own direction.
Here's a metaphor: Science and Technology used to sit next to each other in elementary school, but throughout high school and college Technology got really popular and famous, and Science never changed much. Now when they meet once in a while, to catch up over coffee, Technology still acts like they're as close friends as they were when they were ten, but Science doesn't even know what Technology is talking about when he says things like "widget", really does not think he needs any of the things Technology seems to be trying to give him, and regularly glances under the table at the minute hand on his watch, to make sure he gets back to the lab in time. "Man, Technology really changed", thinks Science, "and he hasn't even asked me how I am…"
I'm friends with both of them, and it's getting more and more difficult to find common ground for these guys. And the hypothetical vox-pop interviewees from before? They just remember Science and Technology from when they were all in elementary school together: they were the two nerds, always sitting next to each other at the front. Surely they're still in touch? They were always so close…
Why no postdoc?
"Oh, you're in Cambridge now?" someone said, "Are you doing a postdoc there? Congrats!"
No, I'm not.
Someone else, around the same time, asked me: "But if you just finished your PhD, why aren't you doing a postdoc now?"
Why would I? I don't want to run my own lab.
So many people stream into a postdoc after their PhD, because that's what's expected of them – at least in certain fields. But THEN what? Are you going to be a postdoc forever? You might have to be, because the message that your supervisory committee may have imprinted on you – that they are preparing you to run your own lab one day – is not exactly in tune with reality.
As Jenny pointed out earlier this week, there are too many postdocs (see also Jeff's article here: pdf). There is no way that all these people will have their own lab in the future. Not unless research funding suddenly increases tenfold, and we all know that's not going to happen… If you get stuck on the idea that this is what you need to do, that you are "being trained to be a PI", then you are going to feel like a failure when you don't make it.
And if you are the kind of person who sees every PhD student as a postdoc in the making, and consider me a failure for not wanting to do a postdoc, then let me sit you down and explain my choice.
I did a PhD not because I wanted to be a PI, but because I needed more exposure to research and the scientific community than I got in my masters. I love research, but I prefer it if someone else does it. I hate experiments. I hate growing cells. I hate waiting for things to happen and starting all over again when something doesn't work. I love when the results are finally in, and everything fits together, and I can relate it to something else and it just all "clicks". I love talking about science, and reading what other people are doing, and connecting one paper with another. I don't want to worry about partial digestions or mycoplasm or bands running off the gel. And that's the kind of crap you worry about on a daily basis when you're in a lab, and you barely get a chance to step back and see the big picture.
I just don't like being at the bench. My favourite part of research was giving talks about it. I understand that for most people it's the other way around. Ironically, the people who make it through years of postdocs so they one day finally qualify to be an assistant professor – a job for which they have to teach – are the same people who much prefer pipettes over PowerPoint. I get upset when I hear someone say that they "have to teach". Of course you do! That's your job! If you hate teaching so much, you should have done something else.
I could have done a postdoc, but I wouldn't really have learned anything useful to me. Yes, it's more experience in science, but only in a tiny corner of it. I like talking to people, organizing events, getting scientists together. You don't learn that as a postdoc. If I had done a postdoc, I would only have taken up funding that someone else really wants, and I would be part of the excess of trainees. It would be another several years of being treated like someone whose life is a failure unless they one day run their own lab.
So other people, go ahead: do a postdoc, and then another one or two more. Clone, digest, lyse, wash, split, block, incubate, fix, stain, and count all you need. Tell me when you're done, and I'll be appropriately excited about the results, and tell you stories about all the other research projects I heard about that were also really exciting. But I don't want to be one of the people working on a teeny tiny parts of science and getting stuck on the idea that my research is the be all and end all. I'd like to stand back and read and listen and get a more general idea of what's going on and who is doing what.
That doesn't mean I gave up or failed. I found the kind of job I wanted all along, one in which I get to read papers and meet scientists and go to conferences, and I didn't need to do a postdoc to get it. For me, postdoc was my backup plan (read that post and see how far I've come!). I told myself I would take a year after getting my PhD to figure out what I wanted to do. And if I really couldn't find anything, then I would start applying to postdocs after that year. It would have been my safety net, and I know it is for many people: if you don't know what you want to do after your PhD, you might as well just do a postdoc and delay the decision. But I did find a job within my own imposed deadline, so I never had to find a postdoc.
I didn't do a postdoc, not because I failed, but because I didn't fail.
My First Day (Cambridge edition)
Alyssa is not the only one who started a new job today. (Hence my post title. She used up the original "My First Day")
I just started as Online Editor for Development , in Cambridge. Eventually, you'll see me pop up on various places online with that hat on, after we launch exciting new things, but today I just sat at my new desk (and only wore a hat outside). I had a great first day, and I'm not just saying that because my new boss reads my blog =) My name was already on the "in/out" board at the door, so that made me feel immediately welcome. I even remembered to switch it to "out" as I left, exceeding my own expectations.
For my new job I'll be learning a lot about the community of developmental biologists. Next week I'll be at a workshop about neural stem cells in development and disease, so I can see what these workshops are all about, meet people, learn some new biology, and think about ways to report from these and other meetings without compromising people's unpublished data or other things they don't want to be all over the internet.
I don't want to give too much away, but if you're a developmental biologist, I will make the internet a
little bit lot better for you this year.
You'll also be glad to know that the positions I left have been expertly filled. I just found out that Joanna Scott took over my part of the Nature Network community management. A few weeks earlier, Ryan Fobel replaced me as Editor-in-Chief of Hypothesis.
I also found a place to live, just met the landlord tonight, and will get the key on Friday, so I won't have to hog Lou's guestroom much longer. (It's Lou's birthday today, have you congratulated her yet?)
So that was my first day. I hope Alyssa's is going great as well!
Interesting Development
A year and one day ago I defended my PhD thesis. (I was planning to post this yesterday, can you tell?) I told myself I'd take one year to figure out what I was going to do next. I spent the first 3 weeks off, then 6 months working for an undergraduate biology department, several weeks traveling, and a couple of months freelancing while searching for fulltime work.
Last week I accepted a job with a science publisher in Cambridge (UK). (That's the real reason I went there .) I'm not sure how much I can say yet about what I'll be doing, but it's definitely interesting and something (I think) I'm good at. Sadly, I can't combine it with working for Nature Network, so after a very brief period doing part-time freelance community managing I've stepped down again.
I'll start in Cambridge on February 1st, so I'm leaving Canada before the end of January. There are a million things I need to do before then, and it's already starting to keep me up at night. I'm going to have to start a dedicated "moving notebook" before I lose my head.
One thing I have already arranged, though, is a pub night for Toronto science folks. Trust me to get my priorities straight! So if you're in the area and want to say hello to other science-minded people, or goodbye to me, or both, come by the "Duke of York":http://york.thedukepubs.ca on December 22nd. I reserved a table in my name after 6 PM, and will be there eating their delicious artichoke/spinach dip.
To science!
I've had a bit of a weird week.
I was in London last Monday, for a job interview. I didn't get the job, but I did get to see Jenny and Stephen for a few minutes after their Fiction Lab, so it was still a worthwhile trip.
I've been looking for work since I came back from vacation this summer, and it's hard. I've been doing some freelance work in the mean time, but that hasn't been enough to live off, and I had to give in and admit that I qualified for Employment Insurance. I don't like living off goverment money for doing nothing, and I'd much rather work.
When I defended my thesis in December, I told myself that I'd take one year of freelancing to figure out what I really want. At the time, I said I didn't want to do a postdoc, but I was afraid that it might have been too inspired by a lack of data and frustrating experiments during my PhD, rather than a real desire to do something else. A year should be enough to get some perspective, and was still short enough that I could find a postdoc if I changed my mind.
When you're in grad school, there is this one path laid out in front of you, and that path leads to a postdoc, and then probably another postdoc, and a tenure track job in the far, far, foggy distance. Leading off from that path, left and right, are scary, dark alleyways. "Teaching","med school", "business", "law school", "editing". There are stories of people who strayed on these paths. Many of them are never heard from again. They "left science".
And I "left", too. But people have some vague idea what I'm doing right now, and the kind of jobs I'm applying to. I got an e-mail a few weeks ago, from someone I used to do volunteer outreach stuff with. I had run into her at graduation, and told her I was looking for work in science publishing. She e-mailed to tell me that she heard a rumour that someone from my old institute got a job at Nature. The rumour was so vague that it didn't come with a name, and she had to ask me "Was that you?"
Sadly, no, that wasn't me. But it says something about the culture of "people who left" that these stories are passed on from person to person, losing information like a game of Broken Telephone. It's special, and it needs to be talked about. Who cares who it was, someone got a job at Nature! It can be done!
In the alleyways off the brightly lit path that leads to postdocs, is a rogue gang of deserters looking for alternative ways to live a life of science. And we've got each others' backs.
Another girl that I also ran into at graduation e-mailed me this week to say that a medical writing company she worked for is looking for more freelance writers. That came just a week after I got a contract for about 70 hours of work with the writing company of the husband of one of my exam committee members. Meanwhile, I'm still applying for editing jobs, I'm networking a lot, and Jenny is casting her editorially trained eye on my CV.
Everyone has just been really helpful. I was in a slump about not finding work, about being bored, and feeling like I didn't belong anywhere, but I do belong somewhere – I just don't have a permanent full-time employer right now.
The real turning point came, as turning points so often do, on Friday night.
I had been invited to a friend's birthday. I know this girl through a group of local blog friends who since scattered all over the place, and I didn't know any of the other people at the party. I sat down at a table with a group of her coworkers. They were all media professionals, but with an entertainment angle rather than science. (My friend writes sarcastic reviews of TV shows for a living.) Of course they asked what I did, and I said "I write about science."
Earlier this year, I had a minor panic attack every time someone asks me what I did, but I found that the common feature of everything I do is some form of writing about science. Whether it's a thesis or comments on a student essay or a press release or a job application – I write about science.
"Science, cool! What kind of science?"
"Well, my PhD was in Biochemistry, but now it's more general. Mostly biology."
"Wow, you have a PhD?" Another guy joined the conversation, and pulled his chair up a little closer so he could ask me all about the H1N1 vaccine. Did I, as a scientist, think it was a government conspiracy? "No", I said, "I think they're just being very careful about pandemics these days."
The waitress brought more beer, and we raised a glass: "To science!" my table mates cheered.
When they all went out for a smoke, I moved my chair to the next table, and met one of my friend's former classmates from her journalism program. She and her boyfriend were also excited to hear about what I did. "Cool, science! Did you hear that, she's a scientist!" I explained what kind of jobs I was interested in, and to her, it made perfect sense to look for something in publishing.
To most people, I am no less of a scientist if I am pursuing a career outside of the lab. Science is science.
And with that, and two new writing assignments to work on, my week changed for the better. I left the birthday party confident that I was doing the right thing.
Just then, I heard glasses clinking at the other table. The smokers had come back inside, and cheered amongst themselves:
"To science!"
Once upon a time, in a lab not far from here…
Remember when I was writing my thesis? I don't really, but I have pictures of it.
Oh, right. It's all starting to come back…
Haha!! That happened every time. Those are words, stupid Word.
I was vaguely reminded of my thesis when I got an e-mail yesterday, telling me that the entire thing is now available online . It's under a Creative Commons license, so you can read it out loud to sleepless children or re-enact the whole thing on YouTube, as long as you credit me. This is even the version with the correct table numbers! (As opposed to the final print version…) If nothing else, you can read the acknowledgements. Don't pretend you don't read the acknowledgements (and nothing else) in everyone's theses.
Back to whatever
Tuesday morning I woke up grumpier than usual – and I usually wake up grumpy in the first place!
It was the day that everyone in Canada went Back to School . I have been going back to school every September since 1982, so this was the first September since 1981 in which I didn't. And it feels weird. I left my full-time job when my contract ended in June, and have been "on vacation" in July and August. But in September you really can't be on vacation anymore.
I'm keeping busy, but for someone who multitasked her way through crazy lab experiments and juggled three to eight extracurricular activities at any given time, I'm not busy enough. Everything that I used to do on the side has now become my main life. Orchestra started again last night, and rather than having to fit rehearsals into my schedule, the weekly gatherings are my schedule. I'm going to New York City later this month to talk about blogging , and booked my return flight to accommodate orchestra. It's the only place I need to be these days.
I do have a lot of time to do things I've been putting off for a while. I'm still not doing them, but I have time to do them now, and that's what matters.
Today I interviewed some people for the LabLit podcast, about science and art, and it's potentially more exciting than Richard and Jenny reading comics from the newspaper out loud . (There's more in that episode, of course. The calculator story made me laugh.)
I'm also writing some things for people here and there , but again, this was stuff I used to do on the side. I'm really stretching everything out to fill my days. I even started cooking properly, and I don't even like cooking. Actually, it now got to the point where I even enjoy it a tiny bit. Remember, my New Year's resolution was to be a better cook, and it looks like it's actually going somewhere! Like Anna , I've also noticed the similarities with lab work. I felt like I was coordinating experiments when I planned to serve the gazpacho (premade, in the fridge) in the 15 minute cooking period of the chili rather than in the 5 minute step before it. Things in the lab work the same way: You can check your e-mail during a blot wash step (10 minutes), and you can go downstairs for coffee during the antibody incubation (1 hour). You can also – if you find yourself juggling three to eight extracurricular activities – use these intervals to e-mail people about an event you're organizing, and to type out meeting notes, respectively. It's maddening, and sometimes there is no time to eat (let alone cook), but I miss it.
I know I said I would never miss lab work, and I don't think that's it. It's those bleeping timers I miss. (Or, if you will, those BLEEP-ing timers) I got a lot more done when I saw the minutes tick away until the next step in the experiment than when I have all day to work on something.
Tomorrow I'm going to set some random timers and see how I do.
Or maybe the day after tomorrow. There's no rush…
In Between Days
I've been accused (by "Richard "look at pictures of my garden and this dead pig" Grant":http://network.nature.com/people/rpg/blog ) of "not blogging". Apparently my pictures don't count as blog posts.
But it's true, I've been avoiding lengthy posts. What do you want me to write about? I'm no longer in the lab, so accounts of PBS-soaked lab journals or eppie-blisters just don't exist anymore. I have been reading scientific papers once in a while, but for a purpose, and the purpose was not "to blog about them". Besides, I've never been one to blog about things in the literature. I'm more of the look at these cool pictures! -type.
I suppose I could be a better curator of the easternblot Flickr group. I get them all in RSS, and only privately enjoy them instead of showcasing them on my other, also neglected, blog. Worst gallery owner ever. I guess I can scratch that off my potential future job list.
My current job, which was only a six-month contract, ends end of this month, so as of next week I'll be mostly unemployed. This entire year was supposed to be some kind of transition year, to try freelancing and think about research, and I'm already at a totally different place than six months ago. At the end of December, after my defense, I wanted to do anything but work in a lab. Now I still don't want to work in a lab, but I'm a bit more specific about what I do want. I don't want to blog about that now, though, so there's another blog topic gone.
The next couple of weeks I will be only minimally involved in science, but maybe that kick-starts a stream of blog ideas. I actually have ideas, I just haven't written anything out because the ideas are too big for blog posts. Stories where every sentence makes me jump up in my seat, grab your arm, and excitedly add "Oh, and that is related to…." I can't write those in blog length posts. I tried. The Erdos post was actually the shortest possible version of an idea I have about a centralized database for anyone involved in any field of academia (not PubMed, but PubEverything). An actual post would take too long, but I don't think my message was very clear from my "look at this XKCD comic"-style post. It's what I do, you see, I just show pictures.
And that is why I haven't blogged properly.
So this is what I've become: I'm blogging about not blogging. The one thing I swore I would never do.
(P.S. Re: the title. Not only am I currently in my "in between" days, I have also been wearing out the Ben Folds version of the song on my iPod lately.)
An Owl with images (non-moving)
This is a picture from when I studied at Hogwarts.
And this was when we did the Sorting Hat Ceremony and I was put in Ravenclaw.


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If yes how would I integrate such a resitor?
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