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Accessories to Improve Travel Trailer Pulling Safety
Three Benefits To Traveling With Aluminum Trailers This Holiday Season
Thinking about doing a family caravan of aluminum trailers in the middle of the winter holiday season? Most people might be more inclined to travel in RVs if they are going on a road trip to meet up with other family for Thanksgiving, Christmas, etc. However, traveling with an aluminum trailer has many benefits over an RV, even in winter. Here are just a few. Aluminum Trailers Collect and Retain Heat Naturally Aluminum trailers collect heat as you roll on down the road. They are, after all, like giant soda pop cans on wheels. If you also leave the shades up on your trailer's windows, it will be like an oven in there when you finally park your trailer for the night. That means you will not have to run the heater endlessly to keep warm if you stay in your trailer in a colder state. (With an RV, you have to constantly use energy to heat the RV and then use a space heater or some other means to stay warm at night.) Aluminum Trailers Require No Additional Gas or Fuel Because you are relying on the fact that a trailer needs no extra fuel or gas to move and your own vehicle pulls it along, you save money. The only travel expense regarding transportation that you have to budget for is the fuel for your towing vehicle. Since an RV consumes a lot more gas and requires more fuel of different types to do what you need it to do, you spend more traveling with the RV than just an aluminum trailer. Aluminum Trailers Can Be Parked and Left Behind While You Drive Around An RV has to go wherever you drive it. When you park it, you park the whole vehicle. At least with an aluminum trailer, you can unhitch the trailer, park it on your relative's yard or driveway, and then drive around in your vehicle. The trailer is less cumbersome and less of a hassle to use. Aluminum Trailers Take up Less Space Additionally, when you are traveling with an aluminum trailer, they take up less space than an RV. If your relatives are concerned about how and where you will park your trailer, you can assure them that the space you need really is not much at all. Even the smallest RVs cannot make that boast—the RVs will take up most of someone's driveway, leaving little room for the other relatives' cars. For more information, contact a professional in your area or visit a website...read more
Design A Revved Up Man Cave While You're Shopping At The Vintage Car Parts Store
Do you have a visit planned to the classic car parts store or auto graveyard to get items for a vintage model you're rebuilding? While you're there, don't overlook other cheap parts that you can use to design a car-themed man cave or rec room. Here are tips for how to turn those parts you'd normally pass by into furniture and accessories that help save waste and make your place look unique. Tables Need a table for your hangout but don't want to spend a fortune on "real" furniture? Stack two tires on top of each other and add a glass round on top–easily purchased at a home decorating store along with sticky disks for attachment. You'll have an instant side table. Swap out the glass for a piece of sheet metal from the hardware store, and you've got the perfect place to store remotes, gaming accessories, and power cords. You could also purchase a beat up coffee table at any garage sale for a few dollars and cover the top with vintage license plates from around the US or around the globe. You'll have no worries about spills or dings. Do you like to indulge in pizza, nachos, or wings while you watch the game? An old spring placed on its side is the perfect item to hold napkins for those messy meals. Key Racks and Coat Hooks When your buddies come over, they want to unload their gear and be comfortable. A line of spark plugs mounted to a two-by-four on the wall makes a great key rack. One item you can always find where there are classic car parts for sale is old crank-style window levers. Mounted on the wall, like the spark plugs, you can use them to hang coats. Another wonderful hanger device is a row of gear shift knobs. Bathroom Fixtures If you have an extra gear shift knob left, you can swap it out for your toilet flush lever to give your man cave powder room an automotive feel. A steering wheel hung on the wall or side of the vanity doubles as a perfect towel hanger, and you can do the same thing by your bar or refreshment area for towels there. Bench or Bar Do you pass by those old pickup trucks at the junk yard and wish you could put them to use? Try using a tailgate as a bench in your rec room by suspending it with seat belt straps from the wall. Mounted a bit higher, the same part makes an ideal bar or buffet. Outdoor Living Finally, if you have an outdoor space you'd like to get more use out of, even in cold weather, you can make your own fire pit from two old tire rims stacked on top of each other. Add a light fixture made from a headlamp (it's beautifully weather resistant by nature), and you'll have a spot where everyone wants to go when they get...read more
How To Protect Your Car From Hail
As a car owner, nothing can make you feel more helpless than being trapped in traffic with hailstones bouncing off of your car. You can actually hear the metal being dented and the glass cracking when huge chunks of ice hit. Even smaller hailstones can cause damage. You can protect your vehicle from much of this damage by taking a few precautions. Cover Obviously, having a garage helps protect your car, but you don't keep it there 24/7. If you are out on the road or simply have to park your car outside most of the time, you can minimize the damage hail can cause. You can invest in a whole-car cover that can be put on your vehicle when hail is on the way. Of course, you have to monitor the weather and act accordingly, but investing in a cover does help. If you are on the road and can exit to a parking garage, do so. A few bucks in parking fees can save you hundreds in hail damage. If you do not want to invest in a cover, you can use old blankets or, in extreme circumstances, your floor mats to help prevent at least some of the dents and cracks. Windshield Coating When hail dents your car, it's an aesthetics problem. You don't like the way the dents look, but they do not affect the performance of the car. It's another issue entirely if your windshield or windows break. You can invest in automotive glass protection that can protect you during a hailstorm and also offer you other benefits. The coating makes your windshield stronger, and it helps resist hail, rocks, and other debris. The coating should reduce glare when you drive at night, and it helps keep the surfaces clear so you have better overall vision. This protective coating is especially important if you simply cannot get your vehicle in a garage or protected with a cover. After all, once the storm starts, you risk physical injury if you try and cover up your car. For more information on auto glass coating, contact a company like SML Window Tint. You can take some steps to protect your vehicle from hail damage. If possible, pull over and drive into a parking garage or stop under an overpass. If you have enough warning, you can use protective covers. Investigate protective glass coatings as well. Remember too, you are more important than your vehicle, so never voluntarily expose yourself to hailstones....read more
Need a Truck Cap to Protect Materials? Things to Consider
If you have a lot of tools or supplies you transfer around in the bed of your truck and you worry about leaving everything exposed all of the time, it's time to get a truck cap. If you aren't thrilled with the way that they look or you have never considered one in the past, there are a lot of advantages to using one. The cap is going to hold items in the back of the truck so you don't have to worry about tying or weighing them down and it's going to keep all of the items dry and clean because the items are sheltered from rain, dust, dirt, and more. Here are a few options you can consider to make the cap look nice, and if you are shopping for a used model. Tinted Windows If you worry that someone may see what you have under your truck cap, look for tinted window options. This way people won't see if there is anything inside the bed of the truck. People won't target items they can't see. If you find a great deal on a used truck cap that you want to buy but the windows on it aren't tinted, contact a local auto body shop to see what the cost would be to have a tint film put on. Color Match It can be hard to find a truck cap that is the exact color of your truck if you are shopping around for used or that is already in stock, or if the manufacturer you want to order from only has a few stock colors. Talk with the local auto body shop about having the cap painted to match your truck. This is going give the truck a cohesive look, and you can make money off the cap when you sell the truck. It's important to remember that the truck cap isn't a permanent accessory that you are adding to the vehicle, and you can take it off if you are in the off season and don't need to haul items, or when you want to clean the truck bed out. If you worry about theft and items getting damaged or lost during transportation, you'll want to find a truck cap dealership such as J & C Campers in your local area that has used and new models for you to consider for your new or used...read more
2 Ways To Keep Rust From Damaging Your Car's Undercarriage
All metal has a vulnerability to the elements. Metal can rust and holes can develop. The more that the metal is exposed to the hard elements and substances that can damage it, the quicker the damage can happen. The metal under your car gets exposed to all kinds of nasty things. When it rains, water gets thrown up to sit in the works. The water, added to the heat of your engine and exhaust, can make rust form faster. Another problem for the bottom of your car is road salt. While many places have stopped using salt during the winter, there are still places that do, and in those places, the salt can really do a job on your car. So, what can you do to help keep your car in good shape? Keep it Clean You may be surprised to find out that washing your car can help keep rust at bay. After all, you use water to wash it, and water is what breaks down the metal in your car. However, you car is generally dried off when you are washing it. The benefits of the water from washing your car outweigh any risks when it comes to road salt. Keeping that stuff off your car will keep it safer. If you choose to go to a car wash, especially in the winter, you can ask for an under wash and for a protectant to be sprayed on your car's undercarriage. Get it Coated Another option that you have is to take your car to an auto body shop or your dealership and get a protective car undercoating. This coating will be sprayed on to the underside of your car. It acts as a barrier between your car and any water or contaminants that could cause the car to rust. The coating is a thin layer and won't affect the running of your car in any way. You may have to have the coating renewed on your car periodically, but the place that does it for you can tell you how often you may need to have that done. Keeping your car in good shape and running well takes a little work. Keeping the undercarriage of your car clean and getting an anti-rust coating on the underside of your car are just two easy things that you can do to keep your car in good repair and help it last...read more
Finally Have a Lawn to Mow? Here's a Quick Guide to Choosing the Perfect Mower
You've moved into your new home and it's not located in a drought region. You finally have a beautiful lawn that you get to tend to. Now you have to go out and buy a lawn mower. Unfortunately, you don't have a clue about the type of mower to purchase. Before you head to the home improvement store to buy your first lawn mower, take a minute to familiarize yourself with the different types of mowers that are available. Manual Push Mowers If you have a small yard, and want to get some real exercise while you mow, the manual push mower is for you. This type of mower doesn't have a motor, which means all the power will be coming from you. The blades are attached in a cylindrical reel that stretches between both sides of the frame. There are several benefits to the push mower, including that it is Low cost Fuel-less Good for the environment If you have small children, it's important that you keep manual push mowers out of their reach. Their tiny fingers can get caught in the blades if they happen to play with the mower when you're not around to supervise. Rotary Mowers If you don't want to put all your effort into pushing a lawn mower around your yard but you're still on a budget, a rotary mower will probably suit your needs. Rotary mowers are powered by a small motor, so you won't have to use all your strength to propel the mower across your lawn. Rotary mowers come in gas powered and electric models. Both models come with an operator-presence control—or dead-man switch—that will stop the blades from rotating as soon as you take your hand off the power switch located on the handle. This protects you from injuries caused by lawn mower blades should you fall or trip during use. Mulching Mowers If you have a large lawn, you may want to consider purchasing a ride-on or walking mulching mower. This type of mower chops your grass clippings into small pieces so that they can remain on your lawn. There are two benefits to this type of mower. First, you never have to rake your lawn when you're done mowing. Second, the grass clippings provide a natural layer of mulch, which helps keep your lawn healthy. Now that you have a lawn, you want to choose the right lawn mower. This handy guide will help you select the mower that will work best for...read more
Signs to Know When Your Transmission Is Failing
If you are someone who relies on their dashboard indicators to inform you that there is something wrong with your car then you may need to find a better solution to knowing when your transmission is failing. Many cars do not have a dashboard icon that inform the driver that their transmission is not working properly and failing to receive transmission repairs in a timely matter can definitely create further and costly damages to your transmission. Your RPM When Shifting When shifting into a higher gear, your RPM should drop, as this puts less stress on your engine when driving at higher speeds. If your RPM does not drop shortly after you shift into a higher gear then you could likely be dealing with poor transmission fluid issues. Like your engine, your transmission does need to receive new fluid periodically, which improves the way that your RPM responds when shifting gears. This won't only improve your driving experience, but will also improve the health of your transmission, which will help prevent further complications. The Response to Your Gear Change If your car is hesitating to pick up speed after changing gears then you are likely facing some issues with your transmission's clutch. The clutch in your transmission is what allows your gears to be changed properly, so you can pick up speed and have a smooth driving experience. Like brake pads, your clutch does and can begin to wear too low levels, which can impact the performance of your transmissions ability to respond quickly when shifting into higher or lower gears. So, if you shift into a higher gear and your car doesn't react shortly after doing so then you may want to have a mechanic inspect your transmission's clutch. Grinding Noises A clear indicator that your transmission is failing can be grinding noises. These grinding noises that you hear are likely cracked or defective gears, which can create major transmission complications if they are not replaced shortly after they become damaged. Cracked gears can create many issues like preventing you from being able to shift into a certain gear and cause your car to become non-operational, which can be a huge inconvenience. So, be sure to look out for grinding noises, as this can mean serious transmission complications. By checking these signs, you will be more informed on why and when your transmission is failing, so you can take action immediately and keep your transmission damages to a minimum. Not only will this protect you from high-cost damages, but it will keep your car in better condition and will allow you to be safer on the road, which is most important. For assistance, talk to a mechanic like American Transmission...read more


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Application ProcessPost Graduate Diploma in Management (PGDM) Executive
Submitting your Application
To apply to IMT's PGDM (Executive) Program, an applicant must complete the online Application Form.
On the Application Form the candidate must provide educational qualifications, contact details, work experience etc. and at least one of the following: registration number for CAT2012/CAT2013/CAT2014/CAT2015 or ID for XAT 2013/2014/2015/2016 or ID for GMAT Test taken between (1 August 2011 to 31 July 2016)
After completing the Application Form, the applicant can make payment by one of two options:
1) Pay directly through credit/debit card: If the payment goes through and 'Application Number' is generated, the application is considered submitted. Applicants will receive a confirmation email within the next 24 hours.
2) Pay through demand draft: The applicant must make a demand draft payable to "Institute of Management Technology" payable at Ghaziabad or Delhi for the amount of Rs 2,000/-. On the Application Form, applicants must provide the demand draft number, name of bank, date, location of bank and amount. After providing these details, the applicant will be directed to a new window that has the details of the information submitted and the 'tear-off' sheet together with an 'Application Form Number'. Applicants should take a printout of this form and keep it for their future reference. Applicants must affix their passport-size self-attested photo to the tear-off sheet and send the demand draft along with it. Once the demand draft and tear-off sheet are received by Admissions Office of IMT Ghaziabad, the status is automatically updated on the website. Applicants will also receive a confirmation email within the next 24 hours.
Note: Applicants are advised to have their demand draft details ready before filling the form.
Short-listing for Interviews:
Applicants may submit any one of test scores CAT 2012/CAT 2013/CAT2014/CAT2015 or XAT 2013 /XAT 2014/2015/2016 or GMAT Test taken between (1 August 2011 to 31 July 2016)
Applicants can also submit more than one test score. IMT will consider the best score before making the final admit offer.
In case you are taking your GMAT post filling up the online application, you can inform the Admissions team via email to firstname.lastname@example.com by attaching scanned copy of your score card by 15 August 2016.
Application will be shortlisted for further process on the basis of your scores plus your overall application credentials. This entails your school and college grades, your work experience (quantity & quality), leadership and managerial potential, extra-curricular activities and motivation to do a business management program.
Short-listed applicants will be called for a Personal Academic Discussion (PAD) round at the center/city/venue they have filled in during their Application Form.
Personal Academic Discussion Round:
The PAD round has 3 sub-rounds namely Presentation, Group Interview and Personal Interview.
- Presentation round:
The aspirant will be asked to make a 20 minutes presentation from his area of work to a faculty and industry panel.
The evaluating panel will comprise of:
- An HR/Industry expert (from industry/faculty)
- Head Admissions from IMT, Ghaziabad
- Senior Faculty from IMT, Ghaziabad
- Head Placements from IMT, Ghaziabad
- Group Interview round:
Subsequently the aspirant will be exposed to a group interview process. In the group interview process the above said panel will interview aspirants in a group of 4-5. The activity will be for 15-20 minutes. The objectives will be to check the following aspects:
- Leadership potential
- Problem solving skills
- Negotiation skills
- Communication skills (listening, speaking)
- Analytical skills
- Team work skills
- Personal Interview Round:
The Last round will comprise of a personal interview process in which aspirant will be interviewed by the panel individually for 10 minutes each. The objectives will be to check and discuss:
- Leadership potential
- Work experience discussion
- Candidates' interests
- Personal background
- Aspirations and growth direction

subset: commoncrawl


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This review is from: PowerColor TurboDuo Radeon R9 290 DirectX 11.2 AXR9 290 4GBD5-TDHE/OC 4GB 512-Bit GDDR5 PCI Express 3.0 HDCP Ready CrossFireX Support Video Card
Pros: I had bad experience with first card I bought and needed to complete an RMA with PowerColor. The RMA went very smooth and suprisingly fast. In total it took about 10 days round trip to get a good card. Thanks Raymond! Oh and I got my rebate check in 31 days. Kudos to PowerColor!
SO, I decided to buy another one of these PowerColor R9 290's. It works great. Overall, very happy with PowerColor.
Cons: -R9 290's in crossfire do run hot but, that was expected
-These card need a quality power supply, 750 W or above
This review is from: PowerColor TurboDuo Radeon R9 290 DirectX 11.2 AXR9 290 4GBD5-TDHE/OC 4GB 512-Bit GDDR5 PCI Express 3.0 HDCP Ready CrossFireX Support Video Card
Pros: -GTX 780 and sometimes even GTX 780Ti levels of performance. All of this for a substantially lower price point than the aforementioned cards
Cons: - Having the exact same problem as the other reviewers
-This card would constantly crash to black or white screen while gaming; hard-locking my system
- Hot and noisy for the brief periods that I was able to play games
- Currently, in the RMA Process with Powercolor. hopefully that will go smoothly
Other Thoughts: Took a chance with Powercolor despite the bad reviews on this specific card. If I end up with a quality working R9 290 from them I will be happy but, right now I'm really regretting my purchaseREAD FULL REVIEW
This review is from: Intel BOXDX79SI LGA 2011 Intel X79 SATA 6Gb/s USB 3.0 ATX Intel Motherboard
Pros: Supposedly stable, efficient, and easily overclockable. Oh and gives good reviews.
Cons: DOES NOT support Ivy Bridge-E processors; because Intel will not release a updated BIOS to support their own CPU's. Pure laziness on Intel. Thank goodness they are getting out of the motherboard business.READ FULL REVIEW


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60Viane Talamaivao
CAREER: He has 19 career starts.
2016: The experienced Talamaivao returns as a starter at right offensive guard as a junior in 2016.
2015: Talamaivao started the second half of his 2015 sophomore season at right offensive guard in 2015 after performing impressively there as a starter in 2014. Overall in 2015, he appeared in 13 games (all but Oregon) and started 8 times (Notre Dame, Utah, California, Arizona, Colorado, UCLA, Stanford in the Pac-12 Championship Game and Wisconsin). He sprained his knee against Colorado and missed the Oregon game.
2014: Talamaivao started USC's final 11 games of 2014 at right offensive guard as a first-year freshman. He saw action in all 13 games of 2014. He made 2014 All-Pac-12 honorable mention, as well as the CollegeFootballNews.com Freshman All-American first team and Scout Freshman All-American second team.
HIGH SCHOOL: He made 2013 Prep Star All-American Dream Team, Student Sports All-American first team, Parade All-American second team, ESPN 300, Cal-Hi Sports All-State first team, Max Preps All-State Division I first team, All-CIF Inland Division, Los Angeles Times All-Area, Orange County Register Fab 15 and Riverside Press Enterprise All-County as a senior offensive lineman at Centennial High in Corona (Calif.). Centennial won the 2013 CIF Inland Division title and played in the CIF Southern California Regional Championship bowl game.
He was a 3-year starter at Centennial. Current Trojan John Plattenburg also previously attended Centennial.
PERSONAL:He is a political science major at USC.


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Continual nitric oxide (NO) synthesis is important in the regulation of vascular tone and thus blood pressure. Whereas classically NO is provided by the enzymatic oxidation of l-arginine via endothelial NO synthase, it is now clear that NO can also be generated in mammals from the reduction of nitrite and nitrate. Thus inorganic nitrate derived either from NO oxidation or from dietary sources may be an important storage form of reactive nitrogen oxides which can be reduced back to nitrite and NO when physiologically required or in pathological conditions. The very short half-life of NO and the ready availability of stored nitrite and nitrate make for a very sensitive and responsive blood pressure control system. This review will examine processes by which these storage forms are produced and how augmentation of dietary nitrate intake may have a beneficial effect on blood pressure and other vascular function in humans.
Soon after the discovery of the l-arginine/nitric oxide (NO) pathway in 1987, it became clear that continual endothelial NO synthesis is important in controlling vascular tone and hence blood pressure in humans.1,2 Vallance et al.3 showed that infusion of l-N monomethyl arginine (LNMMA), an inhibitor of nitric oxide synthase (NOS), when infused into the human forearm causes a doubling of forearm vascular resistance. The surprising but clear conclusion4 from this study was that NO is continually being synthesized and released from arterial vascular endothelium, as LNMMA has no intrinsic vasoconstrictor activity. It was clear, however, that NO itself is short-lived, as it is rapidly oxidized to nitrite in aqueous solutions,4 and directly oxidized to nitrate in the presence of superoxide or oxyhaemoglobin. We now know that inorganic nitrate synthesis in humans (first proved by Mitchell in 1916)5 results (probably entirely) from NO oxidation and may be an important storage form of reactive nitrogen oxides, which can be reduced back to nitrite and then NO under certain physiological and pathological conditions. Importantly, this endogenous source of inorganic nitrate is supplemented in varying amounts by dietary intake of inorganic nitrate.
Nitrate/nitrite/NO cycling in humans
Under normal physiological conditions, nitrite, along with NO and nitrate, is part of a complex biological cycle in mammals. There are several pathways thought to be involved in the modulation of the cycling of nitrate, nitrite, and NO. These include oxidation or reduction by bacteria,6–8 haemoglobin and other heme proteins,9–13 xanthine oxidoreductase (XOR),14–18 NOS,19,20 hypoxia,9,21 acid catalysed,22–25 and indeed UV radiation.26 The relative contributions of each will vary considerably from the normal physiological state through times of severe cellular stress.
Dietary sources of nitrate
In the typical western diet, an individual will consume 1–2 mmols of nitrate per day27,28 which will rapidly and completely be absorbed in the upper gastrointestinal tract;29,30 60% of ingested nitrate is excreted in the urine within 48 h,31 with the fate of the remainder as yet unknown. The half-life of an oral dose of inorganic nitrate is surprisingly long, estimates ranging between 5 and 8 h.24,31 This is mainly because, although it readily passes through the glomerulus into the renal tubule, it is mostly reabsorbed by the proximal renal tubules. The urinary clearance of nitrate is only about 26 mL/min,31 consistent with the observation that the fractional reabsorption of nitrate by renal tubules is about 90% in dogs,32 by a transport mechanism which has not yet been characterized (Figure 1).
Endogenous production of nitrate
NO from the classical l-arginine NOS pathway is rapidly oxidized to nitrate in the presence of oxyhaemoglobin, which yields approximately 1 mmol nitrate per day.33,34 A by-product of this is methaemoglobin. In this oxidized state, haemoglobin is unable to bind oxygen and requires reduction back to functional haemoglobin by methaemoglobin reductase in order to function again.
Entero-salivary circulation of nitrate
Between ingestion or endogenous production and ultimate excretion, circulating nitrate, from whichever source, undergoes complex biological processing in the nitrate/nitrite/NO cycle. From circulating plasma, it is concentrated in the salivary glands and subsequently secreted into the mouth. Approximately 25% of circulating plasma nitrate will be taken up by the salivary glands so that salivary nitrate concentration is at least 10 times that of plasma. On the dorsum of the tongue facultative anaerobes, especially Vionella spp, which can use nitrate instead of oxygen as an alternative electron acceptor, reduce nitrate to nitrite.7 The resulting salivary nitrite concentration is more than 1000 times greater than that of plasma in the resting state.35 This nitrite is then swallowed. In the acidic conditions of the stomach, there is good evidence that nitrite can be reduced to NO, a reaction that occurs spontaneously in acid solutions.24 This intragastric NO production appears to play an important role in regulating gastric blood flow and mucus production36–38 as well as host defence against enteric pathogens.22,39
Evidence that some of the nitrite formed in the mouth is also absorbed into the circulation is provided by studies which show an increase in blood nitrite concentration following oral nitrate loading35,40 (Figure 2).
In addition to this pathway for nitrate reduction by tongue anaerobes, Bernheim and Dixon41 had demonstrated in 1928 that both rat muscle and ox liver could reduce nitrate to nitrite. In liver, this was thought in part due to XOR. This capability of mammals was largely overlooked until Lundberg and Weitzberg's group recently provided evidence for a functional mammalian nitrate reductase enzyme demonstrating elevated levels of nitrite following nitrate administration in germ-free and NOS knockout mice.42 The increased nitrite levels were associated with a significant fall in mean arterial pressure (MAP). The rise in nitrite observed was attenuated by allopurinol, suggesting a role for XOR (having excluded NOS and bacteria as potential sources).
The fate of nitrite
A dose of nitrite administered to experimental animals rapidly disappears. A study in which nitrite was administered to rabbits showed a rapid reduction in plasma concentration from nearly 3000 nm to <1000 nm in <5 min, interpreted as a redistribution phase, but then a slower elimination phase with a half-life of 34 min.43 Kelm44 has shown that in humans the metabolism seems to be more linear with a half-life of 110 s. It was previously thought that reaction with oxyhaemoglobin resulted exclusively in nitrate, but this complex reaction has recently been more carefully studied, and it seems that nitrite can also be further reduced to NO by reaction with haemoglobin,45 which may have physiological importance.46
In plasma, in vitro, nitrite also has a short half-life because it is oxidized to nitrate. It is not yet clear what enzymatic or chemical process is involved in this oxidation reaction. Kim and Lancaster47 demonstrated that the catalysis of the oxidation of nitrite to nitrate in rat hepatocytes and hepatocyte extracts involves a mechanism which uses tetrahydrobiopterin. This would represent a means by which a cell can terminate the reversible reaction between NO and nitrite, thus limiting their activity.
Bryan and Feelisch's group provided some of the most revealing insights into the pharmacology of nitrite,48,49 initially demonstrating that concentrations of nitrite were much higher in vascular tissue than in plasma. Intraperitoneal nitrite injection in rats resulted in rapid absorption from the abdominal cavity with widespread distribution, steady state being achieved after approximately 5 min. A dose–response relationship was evident for the S-nitrosation and heme nitrosylation in all (plasma, red blood cell, heart, liver, kidney, lung) apart from two (brain and aorta) tissues studied. Oxidation to nitrate occurred rather more slowly and indeed a significant increase in nitrate levels was only observed following the highest nitrite dose. In contrast the administration of nitrate intraperitoneally did not produce the S-nitrosation or heme nitrosylation in the time period studied. Interestingly, under the physiological conditions studied there was no detectable formation of NO suggesting nitrite may have a direct signalling effect independent of NO. This may be due to post-translational protein modification by protein nitrosation. It is also possible that nitrite itself exerts a direct blood pressure lowering effect.
XOR has previously been discussed as a potential nitrate reductase. However, it is more conventionally thought of as a nitrite reductase. In tissues and tissue extracts, nitrite generates much more NO than would be expected at acidic pH, suggesting the presence of a catalyst (Figure 3). Nitrite added to the perfusate in a Langendorff heart preparation results in the formation of gaseous NO which is increased following ischaemia.15 The enzymatic mechanism by which nitrite reduction to NO is enhanced is likely to vary in different tissues. There is good evidence that in the rodent heart XOR is involved. Its activity in red blood cells and vascular endothelial cells under normal physiological conditions appears to be minimal and probably does not contribute in any meaningful way to the regulation of resting vascular tone.20 However, with falling pH and hypoxia there appears to be an increase in the nitrite reductase activity of XOR which makes it more important in the setting of ischaemia–reperfusion injury.15–17,20,50
Effects of inorganic nitrate and nitrite on blood pressure
The vasodilatory properties of organic nitrates and nitrites have been known and put to therapeutic use since the latter part of the nineteenth century, with amyl nitrite being used in the treatment of angina,51 and later nitroglycerin which was used by Alfred Nobel. The vasodilatory effect was short-lived, thus organic nitrate and nitrite therapy was limited to 'paroxysmal' conditions. Attention would turn to inorganic nitrite compounds in the search for a longer lasting effect.52,53 Reichert's52 paper On the Physiological Action of Potassium Nitrite reviewed the action of potassium nitrite in a host of biological systems in both human and animal models. One surprising finding was that the administration of potassium nitrite salts would cause a transient rise in blood pressure before a blood pressure lowering effect supervened. Attempts to ascertain which nitrite-containing moieties produced the best therapeutic profile while minimizing potential adverse events continued into the early part of last century.54 One agent that appeared to offer a more controlled, predictable, and sustained hypotensive effect was bismuth subnitrate, which Stieglitz noted required reduction by Bacillus coli to nitrous acid allowing slow release of nitrite ions.55,56 This deduction, that bacterial reduction was a required step before nitrate could have a hypotensive effect, had been made some years earlier following investigations into a series of episodes of methaemoglobinaemia in infants who had been administered bismuth subnitrate as a radiological contrast agent.6 While the period of the turn of the last century was marked by a surge in awareness of the potential for nitrite to produce vasodilatation, concerns about methaemoglobinaemia and later nitrite's role as a putative agent in the development in neoplasia57 reduced interest in the vasodilatory component of nitrites pharmacological action. It is perhaps only in the last 20 years or so that nitrite's key role in normal physiological control of blood pressure among other beneficial effects has attracted renewed attention.
Nitrite and blood pressure
Early investigations had suggested that supra-physiological levels of nitrite had no vasodilatory effect.58 Subsequently the administration of nitrite has been shown to produce vasodilatation in numerous physiologically distinct vascular beds including pulmonary,59–61 cerebral,62–64 and other vascular beds.9,40 The cerebral circulation is worthy of specific consideration when considering the vasodilatory properties and therapeutic potential of nitrite given its autoregulatory system which is key to maintaining cerebral perfusion within desired parameters despite fluctuations in systemic blood pressure. Rifkind and colleagues during a 10 min nitrite infusion showed a biphasic fall in MAP with a falling cerebrovascular resistance which approximately mirrors the fall in MAP.64 Cerebral blood flow, however, is unaffected by the first drop in MAP. Following the second fall in MAP, cerebral blood flow begins to increase. Other studies have shown prevention of vasospasm in a primate subarachnoid haemorrhage model63 or increases in cerebral blood flow in cerebral ischaemia62 following nitrite infusion without any effect on systemic blood pressure. These provide further evidence of nitrite's capacity to produce vasodilatation where vasoconstriction may otherwise supervene and cause harm.
In the pulmonary circulation, whether nebulized61 or administered intravenously59,60 sodium nitrite vasodilates the pulmonary circulation. This attenuated pulmonary hypertension whether induced by hypoxia or infusion of U46619. Interestingly, in Ingram et al.60 study, the pulmonary vasodilation produced by nitrite infusion in man persisted for up to an hour after the nitrite infusion ceased and plasma nitrite had returned to baseline levels.
Deoxyhaemoglobin can reduce nitrite to NO65 resulting in the arterial–venous gradient of plasma nitrite noted by Gladwin's et al.66 This reduction of nitrite, in concentrations found under normal physiological conditions, to NO by deoxyhaemoglobin results in vasodilatation and increased blood flow in the human forearm.9 Considering that metabolism of plasma nitrite increases with falling oxygen tension, Maher et al.21 postulated that this effect would be greatest in the venous circulation under resting conditions. They found that under normoxic conditions low-dose nitrite infusions produced venodilation with no apparent effect on the arterial circulation. As the nitrite dose increased, arterial dilation and an increase in forearm blood flow (FBF) became apparent. Under hypoxic conditions, there was little change to the degree of venodilation. In contrast FBF significantly increased. In the resting state, up to 70% of the circulating blood volume may be in the venous capacitance vessels. Thus, small changes in venous tone may have dramatic effects on systemic blood pressure by decreasing right atrial and ventricular end-diastolic pressure. Venous dilatation and concomitant arterial constriction following administration of nitrite has previously been observed in a study looking into the mechanism behind nitrite-induced circulatory collapse in 1937.67
A significant obstacle to nitrite's vasodilatory activity under aerobic conditions, such as would be expected in the arterial circulation under normal physiological conditions, is the very efficient NO scavenging effect of oxyhaemoglobin.68
Zweier's group showed nitrite reduction to NO and subsequent vasodilatation was mediated by sGC or other heme proteins in the vessel wall.12 Reduction of nitrite by effectors in the vessel wall is an attractive pathway for two reasons: first, this mechanism does not rely on the escape of NO from the red blood cell; and secondly, the concentration of nitrite in vascular tissue is far greater than in plasma.49 Indeed, plasma levels under normal physiological conditions are insufficient to produce arterial dilatation.
Cao and colleagues suggest that nitrite has an indirect effect in promoting vascular NO synthesis. They demonstrated that under hypoxic conditions nitrite promotes ATP synthesis and release by erythrocytes.69 The ATP released under these conditions stimulates endothelial nitric oxide synthase (eNOS) in the vessel wall to produce NO70 with vasodilatation. Nitroglycerin has been reported to have a similar but more modest effect on red blood cell ATP release.71
Interestingly, during Bryan and Feelish's pharmacokinetic study,48 a rise in blood pressure was observed when low doses of nitrite were administered. Other investigators have noted a similar rise in blood pressure when lower doses of nitrite are administered or at the start of an infusion.52,72 Vasoconstriction by sodium nitrite has also been demonstrated in an isolated dog liver model by Geumei et al.73 Bryan and Feelish suggest the rise in blood pressure they observed may represent a feedback mechanism whereby increasing concentrations of nitrite initially inhibit eNOS production of NO before a threshold is reached and a vasorelaxant effect supervenes.
Evidence that nitrate may be the important factor in high vegetable diet and blood pressure reduction
Decreased production of NO is evident in essential hypertension and other conditions associated with elevated blood pressure such as diabetes, hypercholesterolemia, and chronic kidney disease.33,74–78
A diet rich in fruit and vegetables has been shown to be effective in reducing blood pressure.79,80 In addition, it lowers the risk of morbidity and mortality from cardiovascular disease81–83 as diet exhibits such tremendous intra- and inter-individual variation, elucidating which components of such a diet are responsible for this effect is difficult. There is a growing weight of evidence from both human and animal studies that nitrate and nitrite derived from the diet can serve as a source for NO, particularly where it is deficient.84 Indeed, the greatest protective effect on cardiovascular disease is to be found in those diets with the greatest consumption of green leafy and cruciferous vegetables,82,83 which typically have high nitrate contents.85
Using an L-NAME-induced hypertensive rat model, Tsuchiya et al.86,87 demonstrated the ability of dietary nitrite-derived NO to attenuate the ensuing hypertension and ameliorate the renal injury in rats treated with L-NAME for 8 weeks.
Larsen et al.88 showed a significant fall in diastolic and mean arterial blood pressure associated with a rise in plasma nitrite following the administration of oral sodium nitrate to healthy volunteers. Webb et al.,40 using beetroot juice as a source of inorganic nitrate, showed a significant reduction in blood pressure with a maximum effect at 3 h with a strong inverse correlation with plasma nitrite levels. That reduction of nitrate by oral commensal bacteria to nitrite is required to procure a blood pressure lowering effect was demonstrated by the abolition of the rise in plasma nitrite and associated fall in blood pressure if no saliva was swallowed in the 3 h following an oral nitrate load. The administration of an antibacterial mouthwash has a similar effect.89,90 These effects lend strong support to the hypothesis that it is the nitrate content of a diet rich in fruit and vegetables which confers a significant proportion of the cardiovascular benefits of such a diet.80,91
Ahluwalia's group recently demonstrated comparable blood pressure lowering effects between nitrate doses whether administered with beetroot juice or KNO3 capsules.84 These effects were also not apparent when a KCl control was administered. Interestingly, they also demonstrated significant elevations in cGMP concentrations in association with elevated plasma nitrite. NO's effects are known to be mediated by the activation of cGMP.92 This finding provides further evidence to suggest nitrite's effects are mediated via conversion to NO.
Sunlight, nitrite, and blood pressure
The significant concentrations of nitrate in sweat from skin stores from which NO is generated following reduction by skin commensals to nitrite93 which are thought to play a role in host defence94 may have another purpose. A perhaps overlooked aspect of the regulation of blood pressure is the role of UVA radiation, which may partly explain seasonal variations in blood pressure noted by some investigators.95 The first suggestion this might be so is from in vitro work by Matsunaga and Furchgott96 who demonstrated light-mediated relaxation of rabbit aorta in the presence of inorganic nitrite. Oplander et al.26 showed that whole body UVA irradiation resulted in a maximum fall in MAP of 11.9±1.8% from baseline 15 min after UVA exposure with a residual effect up to 1h later. This was accompanied by significant increases in FBF and flow-mediated vasodilatation. Like the complex chemistry observed in the stomach, the reactions taking place in the dermis are complex with numerous potential intermediates and putative effectors. NO gas is liberated from the skin following UV irradiation. There were significant rises in plasma nitroso compound (RX-NO) species in plasma which highly correlated with the fall in blood pressure and a significant rise in plasma nitrite which did not. In addition, there was a significant increase in intracutaneous S-nitrosothiols. Previous work by Mowbray et al.97 suggests that nitrate is the likely storage form of NO in skin, with nitrite as the photo-reactive intermediate with concentrations of S-nitrosothiols being comparatively far lower and thought to be of less significance.
Risk/benefit of increasing nitrate intake to reduce blood pressure
Although nitrates and nitrites have been used medicinally and for curing meat for many centuries (reviewed in a recent paper by Butler and Feelisch98), acute toxic effects have only been encountered at very high doses. The toxicity reported has been principally methaemoglobinaemia, but only when several grams of nitrate salt are administered.99 It has been suggested that some early studies may have shown methaemoglobinaemia with lower doses of nitrate due to contamination with nitrite. Nitrite causes acute toxicity in much smaller doses. The LD 50 of inorganic nitrite in laboratory animals is about 2.6 mmol/kg. If extrapolated to man this equates to a dose of 12 g. In fact is likely to be lower at about 4 g100 with significant methaemoglobinaemia occurring with as little as 1 g (14 mmol).
While the benefits of a diet rich in vegetables, and therefore by extension rich in nitrate, in terms of effect on blood pressure and reduced cardiovascular risk appear clear at a population level, it is prudent to remember that any substance with a pharmacological effect will produce undesirable effects in some. Concern emerged in the 1970s as a result of Tannenbaum and Spiegelhalder's work on the potential of dietary nitrate to form N-nitrosamines.101,102
Both nitrous acid and dinitrogen trioxide which are formed from acidification of nitrite are well-known nitrosating agents.103 Nitrosation of secondary amines present in foodstuffs or drugs104 could lead to the formation of carcinogenic N-nitrosamines (see below) which are known, in animal studies, to predispose to gastric and liver cancers.105
It should be noted, however, that there are problems in extrapolating toxicology studies from these small laboratory animals to man. While generally true for most chemical entities, it is especially relevant in any discussion about potential health risks of nitrate. For example, rats do not appear to have the same mechanisms as humans to concentrate nitrate, iodide, and thiocyanate in salivary glands, a feature of nitrate metabolism in man which is key to any potential benefits or harms.106,107
It had been shown by Magee in 1956 that N-nitrosamines could cause hepatic tumours in rats by forming DNA adducts.108 Numerous studies since have attempted to find a positive correlation between nitrate intake or exposure and cancer. However, most are epidemiologically weak and inconclusive.109 Indeed in 2003, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) concluded: 'Overall, the epidemiological studies showed no consistently increased risk for cancer with increasing consumption of nitrate. These data, combined with the results of the epidemiological studies considered by the Committee at its 44th meeting, do not provide evidence that nitrate is carcinogenic to humans'.110 Furthermore, it has been suggested that it would be surprising from an evolutionary point of view that nitrate would be recovered from glomerular filtrate and actively excreted into the mouth at high concentration if it were a toxic molecule.35
It remains possible that certain subgroups of the human population may be at increased risk of cancer if subject to high levels of dietary nitrate. Winter et al.'s111 paper elegantly demonstrated the formation of nitrosamines in an in vivo system in the human oesophagus. While the ability of a given nitrosamine to induce cancer has considerable inter-species and inter-tissue variation within a species, this is a potentially important finding. Human oesophageal cells can metabolize and activate nitrosamines via the cytochrome p450 enzyme pathway resulting in binding of these metabolites with DNA.112–114 Alcohol, the excessive consumption of which is known to be a risk factor for upper gastrointestinal cancer, inhibits first pass metabolism of nitrosamines by the liver resulting in increased exposure of extra-hepatic organs.115 Thus, for individuals with gastro-oesophageal reflux, the generation of potential carcinogens within the oesophageal lumen in addition to increased circulating nitrosamines may put them at increased risk. It seems reasonable to postulate that those who have subsequently developed dysplasia will be at greater risk still.
Outwith these specific circumstances, nitrite and NO generated in the gastric lumen have a clear role in gastro-protection by increasing gastric blood flow and gastric mucous production.36–38 It also inhibits ulcer formation whether by NSAIDs or in association with H-pylori infection.116,117
Nitrate and nitrite play a key role in modulating blood pressure in both health and disease states. The vast array of surprisingly diverse mechanisms by which NO can be generated from nitrite serve to underline its vital role in regulating vascular tone. Its physiological handling appears to be designed to deliver NO to the point of greatest need with evidence that nitrite reduction increases with increasing hypoxia and falling pH—an effect perhaps most evident in certain disease states. In addition, evidence is emerging that nitrite may have a direct vasoactive effect independent of its role as a precursor for NO.
Conflict of interest: N.B. is a cofounder of Heartbeet Ltd, a non-profit making organization set up to promote the health benefits of dietary nitrate.


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Business, Business News, News & PoliticsFollow
|Business News
Insights into the business world - featuring content from BBC Radio 4's In Business programme, and also Global Business from the BBC World Service.
October 3rd, 2014
Episode 515 of 638 episodes
Insights from two home-grown marketing companies into a country emerging after decades of isolation
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Welcome to the daily audio workout for your head.


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Executive Creative Directors: Juan Cravero, Darío Lanis
Creative Directors: Juan Pablo Lufrano
Copywriters: Juan Pablo Lufrano
Art Directors: Juan Pablo Lufrano
Photographer: Buenavista Fotografía
Account Supervisor: Laura Erobaldi
Advertiser's Supervisor: Ivan Canales
haha awesome stuff!
The concept is only as good as the execution.
Best coffee ad promoting caffein as a waker upper I've seen in a long long long time!
Looks like TBWA/Paris campaign.
But it is not.
Well done guys.
Cool! Love the imaginative effect.
Now if thats coffee, ever wonder what a tea that looks like this will do to you.
>> >> >>
Ok, I must be by myself on this one but I don't think its that good. I mean I know what they are getting at but don't think its that funny. It's like a 3 out of 5.
David Byrne
It's pretty amusing. I'm not sure if it makes me want their coffee, but its a very eye-catching concept.
TopCreatives, the premier online community for creative pros.
This has been done (expressed) more than a few times in "headlines" (mostly for caffinated drinks).
But never have I seen it as a visual. I quite like it.
"Thank you, sir! May I have another?"
wow. but looks more like rub on the face (to make you snooze) than a slap (to wake u up).
Have you seen the Kapal Api TVC from IUM malaysia? wife and husband have fight, then the wife throw the coffee to the husband, and the husband get punched.
same idea?
end of joy, enjoy
Thats pretty cool.
In this case, I think the literal approach works fine, its dramatising the impact of strong coffee to wake you up.
It's only an ad.
Wildly funny and and true. I would have loved to have seen a bit of blur on the arm, hand and face to show some motion. But still among the best stuff here lately.
Perhaps your reading too much into it.
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Tag - Silverlight
Researchers: Silverlight now more vulnerable than Java, Flash
Microsoft's web video and interactive cross-platform content plugin Silverlight is coming under increasing volume of attacks from hackers as of late, according to security reports. As the public awareness of Java and Flash flaws is increasing, Cisco's security researchers are finding an increasng number of systems affected by attacks focused on exploits of Microsoft's Silverlight, as users aren't aware of the increasing proliferation of malware for the platform, or even that they have the plug-in installed.
Parts of Microsoft software roadmap leak online
Microsoft has begun sending out a roadmap that shows some details about its future software products such as Office 15, Internet Explorer 10, and Windows Phone to some of its partners. One of them, CEO of Meetroo Maarten Visser, shared part of it over Twitter, revealing said details. Dated December 22, 2011, the images weren't password-protected. Considering the date, the Windows roadmap doesn't mention anything past the Developer Preview and certainly not the Consumer Preview that launched on February 29.
Google, Microsoft, Netflix want encrypted HTML5 media spec
Google, Microsoft, and Netflix have put forward a proposal that could add a level of copy protection to HTML5 audio and video. Encrypted Media Extensions would let apps on the web and elsewhere use keys to control who has access to a given media stream. It would allow any format that would work in HTML5 as long as the format itself can support some kind of key or bit.
Windows Phone Tango could pack native apps, 120 languages
Microsoft may have inadvertently spoiled many of its plans for Windows Phone's Tango update after an Indian developer presentation was recounted (since pulled at Microsoft's request) this weekend. During the event, WPSauce heard from attendee Karthik Ragubathy that "the next release," possibly Tango, would support truly native apps for the first time. The approach would let apps optimize for performance without having to be written using XNA code intended for games.
Microsoft posts Silverlight 5 in possible last update
As expected, Microsoft has released a major update to its Silverlight plug-in for Windows and Mac computers. Version 5 brings several new features, including hardware decoding for H.264 media and improved 3D graphics performance, however the release is believed to be the final major update for the application framework.
Lovefilm switches from Flash to Silverlight, skips HTML5
UK DVD and streaming video outfit Lovefilm just announced that it will move from Flash-based streaming to Microsoft's Silverlight. The move was prompted by movie studios, as they believed Silverlight offers greater security in the fight against piracy. The studios were apparently fairly adamant, threatening to pull their movies if the change wasn't made.
Microsoft may drop Silverlight after imminent 5 launch
Microsoft may join in decisions to drop proprietary plugins with an exit from Silverlight, insiders mentioned later on Tuesday. Silverlight 5, expected to be finished by the end November, is said by Microsoft partner contacts for ZDNet to be the last-ever version. It might not get any minor updates and may even go without any support beyond Internet Explorer for Windows, backtracking on claims of cross-platform support.
Netflix gets native Chrome OS support
Netflix has tweeted that its @Netflix app is now available for Chromebook owners. The app is available from the Chrome Web Store. Netflix is a offering a one month's free trial to new customers.
Microsoft upgrades SkyDrive with HTML5, drops Silverlight
Microsoft has officially launched its updated SkyDrive service. The new architecture is based on HTML5 instead of Silverlight. The company had said last October it would make this transition to ensure better cross platform compatibility with more devices including iPhones, iPads and smartphones.
HTML5 at last call for comments, near finished
HTML5 community leader Shelley reports that members of the W3C, the international standards body for the Web, are being polled about the proposed new HTML5 standard. If no formal objections are raised before Monday, May 22, then HTML5 would enter "Last Call" status. It could become a standard in 2012.
Now AAPL Stock: 136.66 ( + 0.13 )
Cirrus creates Lightning-headphone dev kit
Apple supplier Cirrus Logic has introduced a MFi-compliant new development kit for companies interested in using Cirrus' chips to create Lightning-based headphones, which -- regardless of whether rumors about Apple dropping the analog headphone jack in its iPhone this fall -- can offer advantages to music-loving iOS device users. The kit mentions some of the advantages of an all-digital headset or headphone connector, including higher-bitrate support, a more customizable experience, and support for power and data transfer into headphone hardware. Several companies already make Lightning headphones, and Apple has supported the concept since June 2014. http://bit.ly/29giiZj
Apple Store app offers Procreate Pocket
The Apple Store app for iPhone, which periodically rewards users with free app gifts, is now offering the iPhone "Pocket" version of drawing app Procreate for those who have the free Apple Store app until July 28. Users who have redeemed the offer by navigating to the "Stores" tab of the app and swiping past the "iPhone Upgrade Program" banner to the "Procreate" banner have noted that only the limited Pocket (iPhone) version of the app is available free, even if the Apple Store app is installed and the offer redeemed on an iPad. The Pocket version currently sells for $3 on the iOS App Store. [32.4MB]
Porsche adds CarPlay to 2017 Panamera
Porsche has added a fifth model of vehicle to its CarPlay-supported lineup, announcing that the 2017 Panamera -- which will arrive in the US in January -- will include Apple's infotainment technology, and be seen on a giant 12.3-inch touchscreen as part of an all-new Porsche Communication Management system. The luxury sedan starts at $99,900 for the 4S model, and scales up to the Panamera Turbo, which sells for $146,900. Other vehicles that currently support CarPlay include the 2016 911 and the 2017 models of Macan, 718 Boxster, and 718 Cayman. The company did not mention support for Google's corresponding Android Auto in its announcement. http://bit.ly/295ZQ94
Apple employees testing wheelchair features
New features included in the forthcoming watchOS 3 are being tested by Apple retail store employees, including a new activity-tracking feature that has been designed with wheelchair users in mind. The move is slightly unusual in that, while retail employees have previously been used to test pre-release versions of OS X and iOS, this marks the first time they've been included in the otherwise developer-only watchOS betas. The company is said to have gone to great lengths to modify the activity tracker for wheelchair users, including changing the "time to stand" notification to "time to roll" and including two wheelchair-centric workout apps. http://bit.ly/2955JDa
SanDisk reveals two 256GB microSDXC cards
SanDisk has introduced two 256GB microSDXC cards. Arriving in August for $150, the Ultra microSDXC UHS-I Premium Edition card offers transfer speeds of up to 95MB/s for reading data. The Extreme microSDXC UHS-I card can read at a fast 100MB/s and write at up to 90MB/s, and will be shipping sometime in the fourth quarter for $200. http://bit.ly/294Q1If
Apple's third-quarter results due July 26
Apple has advised it will be issuing its third-quarter results on July 26, with a conference call to answer investor and analyst queries about the earnings set to take place later that day. The stream of the call will go live at 2pm PT (5pm ET) via Apple's investor site, with the results themselves expected to be released roughly 30 minutes before the call commences. Apple's guidance for the quarter put revenue at between $41 billion and $43 billion. http://apple.co/1oi1Pbm
Twitter stickers slowly roll out to users
Twitter has introduced "stickers," allowing users to add extra graphical elements to their photos before uploading them to the micro-blogging service. A library of hundreds of accessories, props, and emoji will be available to use as stickers, which can be resized, rotated, and placed anywhere on the photograph. Images with stickers will also become searchable with viewers able to select a sticker to see how others use the same graphic in their own posts. Twitter advises stickers will be rolling out to users over the next few weeks, and will work on both the mobile apps and through the browser. http://bit.ly/29bbwUE


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Website Development based of 90% done PSD
This project was successfully completed by surajitsaha24484 for $189 USD in 5 days.Get free quotes for a project like this
Project Budget$30 - $250 USD
Completed In5 days
Total Bids42
Project Description
I have a very elaborately designed PSD detailing the look and behavior of a website that I need implemented quickly. I would like the website to be implemented using Bootstrap, and implement a content management system that will make changes and additions flexible and simple. Sounds like the right way to do this is to use Wordpress or Drupal, so please advise one against the other. This should be a pretty quick and simple project to finish up for someone, I've just not got the time to do it. Looking for a turnaround of a few days, with an additional round of changes that will be awarded as a separate project to the the winning bidder within a week.
Additional and on-going opportunities will result from a job well done. Examples of your work are great! Happy bidding!
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From: firstname.lastname@example.com <firstname.lastname@example.com>Subject: Re: [iris-photos] Who are we?To: firstname.lastname@example.com: Sunday, May 3, 2009, 9:04 AM
How about Dawn of Change for the amoena. Gypsy Romance for the violet and Soloman's Seal for the SA.
In a message dated 5/1/2009 10:37:55 A.M. Mountain Daylight Time, email@example.com writes:
3 Nice unknown surprizes.
Anyone have a Idea?
3 Nice unknown surprizes.
Anyone have a Idea?


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FRCC Student Wins $1,000 Scholarship in Kitchen Design Competition
Suzy Morris, an Interior Design student at Front Range Community College, has earned a $1,000 scholarship in the National Kitchen & Bath Association Charette Design Competition. The competition recognizes students who demonstrate advanced skill in kitchen design by planning a safe, functional kitchen within a three-hour timeframe. Morris's design earned an honorable mention in the


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This review is from: DOLICA WB-3592 Black Camera Case
Pros: Bag is very well built and has plenty of storage capacity. I have my Canon T1i body with one lens attached and a second zoom lens in the main compartment with plenty of room to spare.
I can easily fit all of my accessories in the additional compartments including, charger, AV cables, additional battery, additional SD cards and quick start guide. With all of that in the bad, I still have one side pocket that is completely empty.
Cons: None that I can think of. The main side pocket has a buckle on it and also a zipper. Not sure of the purpose aside from extra security?
Other Thoughts: I had been shopping for a Camera and accessories for weeks before making the purchase on Newegg. Other bags available at retailers in this size and quality were in the $50 range. For $20 I couldn't have asked for anything more.READ FULL REVIEW
This review is from: WD Elements 2TB Desktop External Hard Drive
Pros: Hard to beat at this price (I purchased for $129 at a local electronics store). The casing, although seemingly made of plastic stays cool even during high use - after copying nearly 700GB of data from my PC to this, the drive was still very cool. Drive is also very quiet, have to put my ear to the thing to know that its on.
Cons: Doesn't have a power switch on the back, would be nice but I can live without it. Also, no eSATA or firewire, but at this price can't really complain.
Other Thoughts: Great option if you want to backup large amounts of data. Hard to find a better product at this price. Looks good and gets the job done.READ FULL REVIEW
This review is from: Antec Three Hundred Black Steel ATX Mid Tower Computer Case
Pros: Great ventilation, dropped my system temperature by 8 C from my previous case. Fans are quiet, even when running at high speed. Has plenty of space for HD's and DVD/CD drives. Assembly is easy. Everything is easy to get to and easy to work with.
Cons: Cable management is not great but is very solid for this price point. A little bit of creativity and this case can be a beauty.
Other Thoughts: For the price, there isn't a better case out there. If you're having trouble with cable management, turn your HD's around. Makes things much cleaner inside.READ FULL REVIEW


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Lop Buri
Category : Textiles
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84 Mu 4 Tambon Ban Kuai, Amphoe Mueang, Lop Buri
0 3647 1847
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Produce Matmi Silk, the unique silk of Lop Buri.
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1600 New Phetchaburi Road, Makkasan, Ratchathevi, Bangkok 10400, THAILAND
Tel: 662 250 5500, TAT Contact Center: 1672
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Hamptons International a stunning and imposing family home with a superb leisure complex set in approximately 0.8 acre. The property has undergone extensive modernisation and improvements including a fabulous kitchen/breakfast room all set within a private gated development of similar exclusive properties.
Among the numerous features are a video entry phone system, newly built kitchen with a state of the art German units and under floor heating, a fabulous master suite with balcony overlooking the landscaped rear gardens, Sonos entertainment system throughout the house and the leisure complex, central vacuuming system, maple wood and tiled floors to the ground and first floors, refurbished bathroom suites, bi-fold doors to the kitchen and leisure complex, Cat 5 wiring, solar heating to the swimming pool, stone terracing and timber decking. Viewing will not disappoint.
The property is situated in the village of Stoke Poges approximately 4-5 miles from Gerrards Cross & Beaconsfield and 7 miles from Uxbridge Station (offering both Metropolitan & Piccadilly Line services to London). There are rail stations at both Gerrards Cross/Beaconsfield & Slough linking to London Marylebone and Paddington (respectively). Within the village are facilities for day to day shopping, with the larger shopping centre of Windsor approximately 6 miles distance. Locally there are a range of recreational pursuits, including the prestigious Stoke Park Club set off nearby Park Road.
Templewood park is a select gated development of just five prestigious houses situated off Templewood Lane, a popular residential road with easy access to both Stoke Poges and Farnham Common village centres. Semi rural in nature, it offers considerable seclusion and privacy but with very easy access to the larger towns of Gerrards Cross, Beaconsfield and London. Approached through electronically operated gates, the property sits to the far right hand corner of the development. A gravel driveway to the front of the property is surrounded by lawns and flowering shrubs. Adjacent to the rear is an elevated terrace with views of the rear garden and stone steps leading down to the leisure complex and an extensive area of lawn with a further stone and decked patio space.
Additional Information
South Buckinghamshire is renowned for its excellent range of schooling both state and independent - further information can be sourced via www.buckscc.gov.uk, www.southbucks.gov.uk, www.ofsted.gov.uk or www.schools-search.co.uk (using the Postcode SL2 4).
Private Gated Development
5 Bedrooms
4 Bathrooms
Stunning Leisure Complex
0.8 acres
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Environmental policies (21 - 30 of 585 items)
Safe Drinking Water Act: EPA Should Improve Implementation of Requirements on Whether to Regulate Additional Contaminants
GAO-11-254: Published: May 27, 2011. Publicly Released: Jul 12, 2011.
Under 1996 amendments to the Safe Drinking Water Act, every 5 years the Environmental Protection Agency (EPA) is to determine for at least five contaminants, such as chemicals, whether regulation is warranted, considering those that present the greatest public health concern. Since 1996, EPA had not recommended any new contaminants for regulation until February 2011, when it reversed its controver...
Climate Change: Improvements Needed to Clarify National Priorities and Better Align Them with Federal Funding Decisions
GAO-11-317: Published: May 20, 2011. Publicly Released: Jun 20, 2011.
Climate change poses risks to many environmental and economic systems, including agriculture, infrastructure, and ecosystems. Federal law has periodically required the Office of Management and Budget (OMB) to report on federal climate change funding. GAO was asked to examine (1) federal funding for climate change activities and how these activities are organized; (2) the extent to which methods fo...
Air Quality: Information on Tall Smokestacks and Their Contribution to Interstate Transport of Air Pollution
GAO-11-473: Published: May 11, 2011. Publicly Released: Jun 10, 2011.
Tall smokestacks--stacks of 500 feet or higher, which are primarily used at coal power plants--release air pollutants such as sulfur dioxide (SO2) and nitrogen oxides (NOx) high into the atmosphere to help limit the impact of these emissions on local air quality. Tall stacks can also increase the distance these pollutants travel in the atmosphere and harm air quality and the environment in downwin...
Environmental Protection Agency: Major Management Challenges
GAO-11-422T: Published: Mar 2, 2011. Publicly Released: Mar 2, 2011.
The Environmental Protection Agency's (EPA) overarching mission is to protect human health and the environment by implementing and enforcing the laws intended to improve the quality of the nation's air, water, and lands. EPA's policies and programs affect virtually all segments of the economy, society, and government. As such, it operates in a highly complex and controversial regulatory arena. In...
Electronic Waste: Considerations for Promoting Environmentally Sound Reuse and Recycling
GAO-10-626: Published: Jul 12, 2010. Publicly Released: Aug 11, 2010.
Low recycling rates for used televisions, computers, and other electronics result in the loss of valuable resources, and electronic waste exports risk harming human health and the environment in countries that lack safe recycling and disposal capacity. The Environmental Protection Agency (EPA) regulates the management of used electronics that qualify as hazardous waste and promotes voluntary effor...
Vehicle Fuel Economy: NHTSA and EPA's Partnership for Setting Fuel Economy and Greenhouse Gas Emissions Standards Improved Analysis and Should Be Maintained
GAO-10-336: Published: Feb 25, 2010. Publicly Released: Apr 1, 2010.
In May 2009, the U.S. administration announced plans to increase the Department of Transportation's (DOT) National Highway Traffic Safety Administration's (NHTSA) corporate average fuel economy (CAFE) standards and establish the Environmental Protection Agency's (EPA) greenhouse gas (GHG) emissions standards for vehicles. NHTSA redesigned CAFE standards for light trucks for model years 2008 throug...
Environmental Contamination: Information on the Funding and Cleanup Status of Defense Sites
GAO-10-547T: Published: Mar 17, 2010. Publicly Released: Mar 17, 2010.
Under the Defense Environmental Restoration Program (DERP), the Department of Defense (DOD) is responsible for cleaning up about 5,400 sites on military bases that have been closed under the Base Realignment and Closure (BRAC) process, as well as 21,500 sites on active bases and over 4,700 formerly used defense sites (FUDS), properties that DOD owned or controlled and transferred to other parties...
Oil and Gas Bonds: Bonding Requirements and BLM Expenditures to Reclaim Orphaned Wells
GAO-10-245: Published: Jan 27, 2010. Publicly Released: Feb 26, 2010.
The Federal Land Policy and Management Act of 1976 directs the Department of the Interior (Interior) to manage lands for multiple uses while also taking any action to prevent "unnecessary or undue degradation" of the land. To do this, Interior's Bureau of Land Management (BLM), among other things, requires oil and gas operators to reclaim the land they disturb and post a bond to help ensure they d...
Chemical Regulation: Observations on Improving the Toxic Substances Control Act
GAO-10-292T: Published: Dec 2, 2009. Publicly Released: Dec 2, 2009.
The Environmental Protection Agency (EPA) is authorized under the Toxic Substances Control Act (TSCA) to obtain information on the risks of chemicals and to control those that it determines to pose an unreasonable risk. EPA also conducts assessments of chemicals under its Integrated Risk Information System (IRIS) program. Nonetheless, EPA does not have sufficient information to determine whether i...
Federal Electronics Management: Federal Agencies Could Improve Participation in EPA's Initiatives for Environmentally Preferable Electronic Products
GAO-10-196T: Published: Oct 27, 2009. Publicly Released: Oct 27, 2009.
Advancing technology has led to increasing sales of new electronic devices. With this increase comes the dilemma of managing them at the end of their useful lives. If discarded with common trash, a number of environmental impacts may result, ranging from the loss of valuable resources to the potential release of toxic substances, such as lead. If recycled, they may be exported to countries with wa...


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...a comfortable, comprehensive approach to breast care tailored to meet your individual needs.
The American Cancer Society encourages all women age 40 and older to have an annual mammogram for early detection and more effective treatment.
Our goal at the Adventist HealthCare Shady Grove Breast Center is to provide you with a comfortable and comprehensive approach to breast care that's tailored to meet your individual needs. From state-of-the-art women's imaging services, such as 3D mammography, to one-on-one consultations with a dedicated breast surgeon or breast certified radiologist, to resource and support following your breast cancer diagnosis by a breast navigator, all your breast health care needs are met inside one convenient and comprehensive center located in Rockville, Maryland.
Our comprehensive breast services include:
Our team of experienced, highly trained physicians, breast navigator, technologists and staff aim to make your experience as seamless and pleasant as possible. We offer state-of-the-art technology and equipment operated by licensed, certified or registered technical staff who function under the direct supervision of our physicians and radiologists. Through the use of innovative technology and highly qualified medical personnel, we provide early detection and diagnosis of breast cancer. With easy appointment scheduling, featuring same day openings, you'll be able to find a time that works best with your busy lifestyle. All exams are completed the same day as your initial visit, and in some cases you'll receive the results and diagnosis before heading home.
Adventist HealthCare Imaging offers convenient radiology & diagnostic imaging locations throughout Montgomery County.
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What's for supper tonight?
Chicken Thighs Adobo, which includes carrots and onion (from our freezer experiment)
Reheated sweet potatoes
Homemade Cuban bread (Dollygirl and I baked some this morning)
Oranges, bananas
Dangerous Chocolate Cake in a Cereal Bowl
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Thursday, October 11, 2012
What's for supper? Kind of Philippines-Cuban fusion
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Does this attraction provide visitors with a taste of the local culture?
Is this attraction free to the public?
Is gratuity suggested at this attraction?
Would this be a good rainy day activity?
Is there food available at this attraction?
Is a car required to access this attraction?
Is this attraction accessible using public transportation?
Is this attraction closed during certain parts of the year?
Is this attraction wheelchair accessible?
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We love the Cherry Street Farmer's Market! The Market is open from 7 to 11 a.m. each Saturday between April and October and has a variety of booths with offerings from fresh...
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We love the Cherry Street Farmer's Market! The Market is open from 7 to 11 a.m. each Saturday between April and October and has a variety of booths with offerings from fresh organic vegetables and fruit, to local grassfed meats and fresh eggs, to fresh dairy and cheeses, plants/herbs and fresh cut flowers, to prepared foods and arts & crafts-type...
This is a wonderful farmer's market. I try to stop whenever I get the chance. Tulsa has done a nice job to maintain their farmer's market and the options are nice! Love to buy my spices here.
My first time to visit was this spring and the prices are exceptionally high even for organic produce for what essentially is an average shopping experience. Will likely return a couple of more times through berrry and corn season to review options, but fear that this market will continue to be a huge disappointment.
My wife and I moved from a fairly large city to a smaller city several years ago, and we have missed the "big city" farmers market ever since. When we visited Tulsa for an overnight stay, we decided to drop by the Cherry Street Farmers Market to experience a large farmers market again. We were certainly not disappointed. The market...
This is almost like a weekly festival and its a great way to start a Saturday from April until October. There are a a good variety of vendors: from the most delicious and inexpensive milk I've found in the region (Lomah Dairy) to large varieties of heirloom plants vendors, to wholesome vegetables and even delicious food trucks. This is a...
We were delighted with our first visit to this farmers market. We especially loved finding exoctic chile pepper plants that we have never been able to find elsewhere. At some other farmers markets there were people selling produce that obviously wasn't grown by them. We look forward to the spring and the market opening again!
Going to this market was the highlight of our stay in Tulsa! They have many plant and produce vendors all with fresh wonderful products. There's even a vegetarian and vegan food booth where we bought the most wonderful breakfast burritos! It's a fun time filled with friendly people and a great atmosphere.
I love getting up early on Saturday mornings and walking around the Farmers Market with fellow TUlsans and visitors...and dogs...there are plants for gardens, sometimes crafts, seasonal food, breads,etc and even sometimes even music...it is a wonderful gathering place and a great way to support locally grown, fresh produce... maryjo
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Obesity, commonly defined as a body mass index (BMI) greater than 30 kg/m2, is associated with an increased risk for a number of metabolic derangements including type 2 diabetes mellitus (T2D), hypertension (HTN), dyslipidemia including hypertriglyceridemia (hiTRI) and low HDL levels (loHDL), as well as cardiovascular disease and overall mortality. Morbid obesity (BMI>40 kg/m2), which afflicts over 5% of the U.S. population, further increases disease burden and risk of mortality. Weight loss is effective at decreasing these risks, as well as ameliorating disease severity, thus reducing body weight in the morbidly obese is a major clinical goal. Currently available dietary and pharmacological modalities can produce small to moderate levels of weight loss, which can have significant impact on comorbidities, but are difficult to achieve or sustain in many patients. Bariatric surgery has thus emerged as a highly effective therapy for long-term weight loss in morbidly obese patients, and more recently as a surgical therapy for the potential cure of type 2 diabetes. However, the degree of weight loss and improvement in specific co-morbid conditions is variable. Our long-term objectives are to identify the molecular and genetic determinants of dietary and surgical weight loss in the morbidly obese, as well as the factors related to the resolution of co-morbid conditions. Based upon heritability and linkage studies, as well as genome wide association studies, genetic variation appears to play a strong role in obesity and related co-morbid conditions. Only a few of these genes/loci have been studied in the context of morbid obesity. Our primary hypothesis is that genetic variants confer resistance to weight loss therapies and inhibit weight-loss induced resolution of co-morbid conditions. To date, only small studies of a few candidate genes have been evaluated in diet and surgical weight loss. The specific goals of this proposal are to first identify common genetic variants associated with weight loss outcomes through genotyping "Metabochip" SNPs in individuals who have undergone a prudent hypocaloric weight loss program and Roux-en-Y gastric bypass surgery. We will then test for association between SNPs and weight loss outcomes. All trait-associated markers will be validated in independent cohorts. We will then identify rare genetic variants associated with weight loss outcomes by direct sequencing of selected candidate genes, as well as prioritized genes associated with Metabochip loci. Finally, we will identify genes whose expression levels are associated with weight loss outcomes through profiling hepatic gene expression in liver RNA and identify both common and rare variants associated with these genes. Completion of these aims will enhance our understanding of the molecular mechanisms underlying heterogeneity in weight loss outcomes following dietary and surgical interventions in the morbidly obese population.
Severely obese people suffer from many medical problems such as diabetes, high blood pressure, and high cholesterol. Losing weight can help these problems in some, but not all, people and those who try to lose weight through either diet or surgery often regain weight. Little is known about why this occurs. This study will determine whether genes affect how people lose weight and whether their medical problems improve. Identifying these factors may help guide which types of weight loss therapies should be performed in the extremely obese population.
|Wood, G Craig; Benotti, Peter; Gerhard, Glenn S et al. (2014) A patient-centered electronic tool for weight loss outcomes after Roux-en-Y gastric bypass. J Obes 2014:364941
|Cantley, Jennifer L; Vatner, Daniel F; Galbo, Thomas et al. (2014) Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. Am J Physiol Endocrinol Metab 307:E773-83
|Gerhard, G S; Styer, A M; Strodel, W E et al. (2014) Gene expression profiling in subcutaneous, visceral and epigastric adipose tissues of patients with extreme obesity. Int J Obes (Lond) 38:371-8
|Still, Christopher D; Wood, G Craig; Benotti, Peter et al. (2014) Preoperative prediction of type 2 diabetes remission after Roux-en-Y gastric bypass surgery: a retrospective cohort study. Lancet Diabetes Endocrinol 2:38-45
|Hirsch, Annemarie G; Wood, G Craig; Bailey-Davis, Lisa et al. (2014) Collateral weight loss in children living with adult bariatric surgery patients: a case control study. Obesity (Silver Spring) 22:2224-9
|Still, Christopher D; Wood, G Craig; Chu, Xin et al. (2014) Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery. Obesity (Silver Spring) 22:888-94
|Benotti, Peter; Wood, G Craig; Winegar, Deborah A et al. (2014) Risk factors associated with mortality after Roux-en-Y gastric bypass surgery. Ann Surg 259:123-30
|Rinella, Erica S; Still, Christopher; Shao, Yongzhao et al. (2013) Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab 98:E1131-6
|Parikh, Manish; Hetherington, Jessica; Sheth, Sheetal et al. (2013) Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations. Surg Obes Relat Dis 9:436-41
|Kumashiro, Naoki; Yoshimura, Toru; Cantley, Jennifer L et al. (2013) Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology 57:1763-72
Showing the most recent 10 out of 19 publications


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1. From this delectable baby.
Jonathan Ernst / Getty Images
2. And this one.
Stacy Bengs / AP
3. And this one.
The Quad City Times, Kevin E. Schmidt / AP
4. From this youthful little girl.
Bruce Bennett / Getty Images
5. And this one.
The Roanoke Times, Kyle Green, Pool / AP
6. And this one.
Chris McGrath / Getty Images
7. From this spry ginger.
Jim Cole / AP
8. And this emotional one.
Steve Helber / AP
9. From all these energetic youths.
Matt Rourke / AP
Matt Rourke / AP
11. From this exceptionally tiny baby.
Joe Raedle / Getty Images
12. From this girl in purple crocs.
Scott Olson / Getty Images
13. From this youthful waitress.
The Roanoke Times, Kyle Green, Pool / AP
14. From this little soccer player.
Drew Hallowell / Getty Images
Drew Hallowell / Getty Images
16. From this toddler in a hat.
17. From these young, fit Olympians.
Jonathan Ernst / Reuters
Chip Somodevilla / Getty Images
Chip Somodevilla / Getty Images
20. From this chunky tot.
21. And this one in jean overalls.
Photo / AP
22. From this vivacious biker chick.
Carolyn Kaster, File / AP
23. (Who's obviously young at heart)
Carolyn Kaster, File / AP
24. From Amy Poehler.
NBC, David Giesbrecht / AP
25. And from Sesame Street.
Bryan Bedder / Getty Images
Happy B'Day, Joe! Never change.
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Soft cotton duck drapes nicely and has a subtle, woven texture. These classic panels have a 3" rod pocket and back tabs. The matching valance is pleated and trimmed with button accents for a casual look. It has a 3" rod pocket with 1" header and 15" drop. 100% cotton. Machine washable.
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Directed by Richard Anasky
Starring Lily Walker, Greg Freeman, Jay Ingle
"It's gonna be the shit movie of the year."
Although it's been marketed as a slasher flick, the crazed Actress Apocalypse is actually an over-the-top 'mockumentary' about two demented brothers and their flailing attempts at making a micro-budgeted flick about a big gay Indian. It opens with the two Lincoln brothers - the uptight David (Garo Nigoghossian) and loony, long-haired, sex-obsessed Vance (Greg Freeman) - as they wait in their shed for their actress on the first day of filming a micro-budget epic called Clearwater Canyon. And wait. And wait. The brothers start turning on one another almost immediately, and once the actress does, finally, show up, she's treated more like a hostage victim than a cast member. Things go from bad to worse, and the unhinged Vance decides to take over production. He changes the storyline into some shit about zombies and spends the rest of the movie 'auditioning' actresses. And when I say 'audition', I mean...well, you'll have to see it to know what I mean, but I will say that there's tons of nudity, and it's not called "Actress Apocalypse" for nothin'.
The most remarkable thing about this film is it's lightning-fast editing and it's use of trippy, psychedelic color schemes, both of which do wonders for covering up it's obvious budgetary limits. The soundtrack, by super-stoner band Space Probe Taurus, provides a sleazy, sweaty atmosphere as well, the perfect complement to all the gyrating flesh on display. The script is mostly improvised, and while it's never really funny, it's relentlessly obnoxious, mean-spirited, and evil, which is almost as good as funny.
Clip: Actress Apocalypse deleted scene
- Ken McIntyre