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The idea that this could be a non-party campaign is fast fading. There will probably be a Labour and Tory primary - (there'll be an outcry if either party tries an inside fix). That will leave just one candidate each, with the others banned from running against their own. Labour is pondering over how to stop Livingstone sweeping the board in a primary, which their secret polling indicates. He laughs that they are trying to draw up a special London constitution that would ban him from standing ("No one with a nasal voice from south London, for instance," he suggests).
This is not just spite on Labour's side, but good sense: he might win the primary but couldn't win the election. Psephologists reckon the chances are stacked against any Labour candidate, let alone Livingstone who, though still much loved, is the least likely to attract wavering Tory votes. For the first London mayoral election will hit mid-term, in the middle of an as yet unquantifiable downturn in the economy.
The heart sinks at watching this bright new idea already mired in the stale old Westminster mind-set. How are Londoners to be ignited by a new municipal enthusiasm if it's all just a dreary re-run of national politics? What's more, Labour is likely to lose.
The deadly secret that emerges from Labour's private polling is that Londoners passionately do not want a party-political candidate. Almost anyone else is preferred - even Branson, although his record for doing public good is negligible and his ability to clean up streets or run trains is not legendary.
Surely there must be a local hero above the political fray, who could fire the imagination across the increasingly artificial party divide? Yes, there is, and now he flips his independent hat into the ring, a battered old cloth cap tossed in from far outside Westminster. He is John Bird, founder of The Big Issue, the street magazine and charity that helps get the homeless on their feet. Eccentric, extraordinary but worldly wise, his candidacy promises that breath of life in what so far has been a cautious, tip-toe debate.
He is any spin-doctor's nightmare candidate. He has a past from hell, an unconventional life and a political innocence that could trip him up - or be the making of him. How about this for a list of serious disqualifications for winning high elected office? A childhood in borstals, an adolescence on probation, many a spell in police cells for drunkenness, not much education and his only political experience has been 10 years in the Workers' Revolutionary Party.
He has a big knocked-about 51-year-old bruiser's face, (he's broken his nose four times) and he spends every Friday night roaming the pubs, streets and drinking clubs of London, only stumbling home in the morning. He takes exercise on a small trampoline in the corner of his office, which could have him mistaken for a yogic flying candidate.
But Bird is London's closest thing to a saint, and now has an MBE to prove it. He set up The Big Issue as a charity for street sellers to earn their way out of beggary, and it now sells some 250,000 and wins editorial awards. The profits fund an agency that helps thousands of the homeless back into mainstream life.
He has a huge homeless army of supporters willing to do anything for him and no other candidate will ever know London so intimately: its high life, low dives, high streets and mean streets. He's been a cab driver (has the Knowledge), knows the sniff, sight and sound of every inch of the city, is a keen observer, often at night, of its subtly shifting communities and is an avid reader of London history. He says cabbies and coppers and all sorts are telling him to go for the job, so he will.
What does he stand for? An apocalyptic sense that London no longer thrives, but chokes on its own filth and pollution, and is in danger from rack- rent landlords, social strife, and fear of crime everywhere; its street life is dying and, above all, its transport system is a creeking, failing disaster. "Only 13 per cent of commuters come into London by car. Why are they allowed to screw up the streets, the air and the buses for the other 87 per cent? Even if you live in Pinner or Bromley, the well-to- do are suffering from London's ills too. It'll be a paupers' campaign, yet one that reaches out to the suburbs with the same message."
What sort of mayor would he be? "One who knows he doesn't know it all. I'll be the conductor of an orchestra of experts and talents." He talks admiringly of much that mayor Rudolph Giuliani has done in New York. His Marxist past long behind him, he no longer looks to big government to solve the problems, but for communities to rejuvenate themselves and take their own action. He despises Livingstone's empty red-flag-flying posturing, and blames him for the destruction of the GLC, promising that he won't set up a rival empire against the Government, but will work with it.
His approach to the homeless has always been tough. They have to pull themselves up by their own efforts, not be victims waiting for handouts. Everyone, he complains, waits for someone else to solve their problems - dog shit, crime or vandalism - instead of taking control of their own communities. He wants to get people volunteering as never before, ordinary people who've never been asked to help with anything. "Rights and responsibilities", he says, not unlike Blair, but without the preaching.
Some ideas, innocently mooted, could frighten the living daylights out of business: he talks of auditing businesses for how much they use and pollute, expecting them to give back unseen costs, such as transporting their workers. He talks of stopping great building development, in favour of cleaning up the old streets and leaving things as they are.
His love of London is infectious and genuine. His eyes gleam with redemptionist fervour as he speaks of reviving community action. As an earthy, practical, non-preachy character, he might be able to do what sounds like hollow words in the mouths of ordinary politicians. After all, he's done it himself.
If anyone can beat the party machines, John Bird can. If he loses, he will add to the gaiety of the campaign, making the others look like bloodless political stooges up against his stirring rambunctiousness. But if Labour does secretly fear defeat in London, why not stand back from the fray, loudly proclaiming the principle that all new city mayors should be candidates independent of the old party machines?Reuse content


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Bill Self postgame press conference: Missouri
Kansas coach Bill Self said his team's 87-86 overtime victory over Missouri was one of the best home wins he's been a part of. Self talked to reporters on Saturday, Feb. 18, 2012, at Allen Fieldhouse.
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The Scorpion™ Storm MG features a 30mW green laser module and four operating modes. It creates a unique star field effect with many patterns and hundreds of beams.Built-in automatic and sound...More
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The Rescuers
Format: DVD
Summary: Two brave mice try to rescue a kidnapped young orphan from the evil Madame Medusa, who is obsessed with getting her hands on the world's largest diamond.
Series: Disney DVD.
Current Holds: 0
System Availability: 10 (of 26)
Call Number: DVD RES5863
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Incentive Programs
The Board of Directors of Husqvarna will evaluate on a yearly basis whether or not a long-term incentive program (e.g. share or share price based) shall be proposed to the Annual General Meeting.
The purpose of the incentive programs shall be to maintain and attract competent managers to the Group. Descriptions of the currently implemented incentive programs can be found in the 2015 Annual Report.


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The number of people taking low-paid, part-time jobs owing to a lack of full-time work is one of Britain's secret crises, the country's leading trade unionist has warned.
Frances O'Grady, the newly appointed general secretary of the Trades Union Congress, said the problem of "under-employment" has been masked by good news on falling unemployment and that the country needs "a change of direction".
"The real story is the massive growth in under-employment, people forced into often low-paid, part-time jobs when they want full-time steady ones," she told the BBC.
"We've got a real problem in terms of short-termism in the UK and we need an active industrial strategy, exactly as Lord Heseltine recommended to the Government.
"It means we need real public investment in our transport system, our energy infrastructure system. While the Government did announce another £5bn, that was a net loss of £15bn because it cut investment in our infrastructure system. Those are false economies for the long-term growth of the economy."
Ms O'Grady told i that the dearth of women at the top of British companies can only be addressed by introducing boardroom quotas.
"We need to break down the group-think that is too evident in boardroom decisions," she said.
- More about:
- Employment
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Barbecue Ribbetts
|1 Clove (5 gm), minced
|Vegetable oil
|1 Tablespoon
|1⁄2 Cup (8 tbs)
|Steak sauce
|1⁄3 Cup (5.33 tbs)
|Chili sauce
|1⁄4 Cup (4 tbs)
|Firmly packed light brown sugar
|2 Tablespoon
|Thin lemon slices
|2 (Fresh)
|Liquid hot pepper seasoning
|1⁄2 Teaspoon
|Pork baby back ribs
|2 1⁄2 Pound, split
In medium saucepan, over low heat, cook garlic in oil until tender.
Stir in ketchup, steak sauce, chili sauce, brown sugar, lemon slices and hot pepper seasoning; simmer 1 to 2 minutes or until heated through.
Arrange ribs on rack in large roasting pan.
Bake at 400°F for 30 minutes.
Brush ribs generously with prepared sauce.
Grill over medium heat for 20 to 25 minutes or until done, turning and brushing often with remaining sauce.
Slice into individual ribs to serve.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 319 Calories from Fat 179
% Daily Value*
Total Fat 20 g30.6%
Saturated Fat 7.2 g36.2%
Trans Fat 0 g
Cholesterol 81 mg27%
Sodium 741.7 mg30.9%
Total Carbohydrates 16 g5.3%
Dietary Fiber 0.14 g0.54%
Sugars 13.8 g
Protein 21 g42.3%
Vitamin A 1.3% Vitamin C 2.8%
Calcium 0.5% Iron 0.51%
*Based on a 2000 Calorie diet


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Marine Harvest questions ownership restrictions
By SeafoodSource staff
Published on Tuesday, October 12, 2010
Marine Harvest AS on Tuesday filed a complaint with the European Free Trade Agreement's Surveillance Authority (ESA), arguing that Norway's ownership restrictions are preventing it from growing.
The world's largest farmed salmon producer said it is excluded from participating in the government's strategy for a sustainable aquaculture industry and the ongoing transition to production in larger zones, which could lead to industry consolidation. The company said it is seeking permission to participate in the consolidation.
"In our view, the present ownership regulations of the aquaculture industry are outdated," said Marit Solberg, managing director of Marine Harvest Norway AS. "The regulations also, for all practical purposes, apply to one company only and thereby distort competition. We want to contribute actively in securing a sustainable development of this industry and, consequently, we would like to participate in this consolidation process."
According to the existing ownership restrictions, a company has to apply to the Norwegian Ministry of Fisheries and Coastal Affairs for permission to acquire more than 15 percent of the total number of licenses, and a company is prohibited from acquiring more than 25 percent of all licenses. Marine Harvest Norway currently holds 216 standard licenses to produce edible fish, which corresponds to about 22 percent of the total licensed biomass.
"We have seen many changes within this industry since the restrictions on ownership were approved in 2005," said Solberg. "The sustainability challenges are more prominent, the industry has grown and become more international, and Marine Harvest of today was not even established when the current regulations were discussed. In our opinion, the present regulations restrict a development of the industry toward larger entities [that] can secure a sustainable development of the industry.
"As a consequence, we have chosen to make use of our right to present today's regulations to ESA for evaluation, and we anticipate the Norwegian government's interest in modernizing the regulations," added Solberg.All Aquaculture stories >


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Lynne Cazaly on Making Sense using Visual Communications
Lynne Cazaly spoke at the recent Agile New Zealand conference on the importance of clarity and sense-making in a world where VUCA (volatility, uncertainty, complexity, ambiguity) is the norm. She presented ideas on how to convey messages more effectively using visual tools and gave the audience a quickfire class on communicating using simple images.
Agile and SOA, Hand in Glove?
Agile is the hand that works in the glove. SOA is the glove, the scope is enterprise wide. Most principles of SOA and Agile are not in conflict. When they are, they keep each other sane. Agile development without a clear vision of the goals and objectives of the company is futile. SOA without a clear vision how to make it real using agile development principles is a waste of time and money.
"Who Do You Trust?" by Linda Rising
During Agile 2008, Dr. Linda Rising held a presentation centered on experiments conducted many years ago, presenting how deep, powerfully affecting, and difficult to avoid are human "prejudices" and "stereotypes". This article is a summary of that presentation.
Using Numbers to Communicate - in the Spirit of Agile
Developers and the business use numbers differently, leading to poor communication. Here the "Spirit of Agile" tells a developer the trick: translate non-computational issues into number language. 3


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Waterfront Vacation Home
From $193 / night
|Per night:
|$195 - $375
|Per week:
|$1,350 - $2,225
|Pets allowed:
Bedrooms: 2
Bathrooms: 2
Sleeps: 6
Type: Home
Pets allowed: No
Internet: No
- 2 bedrooms/2 bathrooms
- Large back porch with view of Spokane River
- Hot tub
- Large living room
- Fully equipped kitchen
- Washer & dryer
- Dock house
- Large dock
- 2 jet ski lifts
- 1 boat parking
- Large grassy back yard leading to the dock
- Sandy Beach with fire pit
- Parking for up to 6 to 8 cars
Disabled Account
About the owner
Owner Profile
|Jun 23 2017
|Jul 07 2017
|Jul 07 2017
|Oct 28 2017
|Full Period
|Oct 29 2017
|Dec 28 2017
|Full Period
|Check In: 11 a.m. Check Out: 11 a.m.
|Lodging tax: 8%
|Deposits: Damage Deposit-$200.00 Refundable
|Payment Options: Cashier's Check, Money Order
|Other Fees: $100 non Refundable Cleaning fee will be added to rental rate.
Reviews (11)
Reviews for this vacation home rental in Coeur d'Alene, Idaho
More than I could have hoped for!
Meg Onstad
Pullman, WA
More than I could have hoped for!
July 27, 2014
What an amazing weekend we had at this home. We stayed for a bachelorette, and had several girls come over to CDA. The house was so wonderful and relaxing, we barely left it to go into town. Pat was amazingly friendly and the home was stocked with everything you could need for a home away from home. We made in house meals every night (grilled, baked, and used their skillet, slow cooker etc.), and they have literally thought of everything a group of people may need for the weekend. The backyard is large and beautiful. The back patio was a favorite hangout spot for the weekend. We used the fire pit, the hot tub, the boat dock, both the kayak and paddle boat, and used the floaties and lifejackets that were available in their dock house. There are extra blankets, pillows, and towels, so there was literally access to anything that we needed. He had coffee for the coffee maker and he even stocked the refrigerator with bottled water. Thank you Pat for an amazing weekend that a group of girls will never forget.
Fantastic place..great location
Judy Hunt
Spokane, WA
Fantastic place..great location
July 18, 2014
This place is secluded yet very convenient with easy access to Post Falls and Coeur d'Alene. Pat and May go the extra mile to have it clean and ready for your stay... We really enjoyed the all the special features... view, wonderful dock with seating to relax and enjoy that view, lovely yard, covered deck with plenty of seating, large nice kitchen, paddle boat & 2 person kayak, bbq .. We have already recommended it to others and we just left yesterday! Thank you so much Pat.. it is a truly relaxing and comfortable place to stay!
Great location
Judy Baerg
Maui, Hi
Great location
October 21, 2013
I met up with friends from various places and we had a very nice relaxing time. Although it was a little colder time of year, I could see how it would be great in the summer with all the water activities.
Family stay
Brittney Storm Howard
Family stay
September 6, 2013
We had a great time At this place! the veiw was beautiful and the house was verry nice! we had three smally Family's stay here. My self, my husband and our baby , My sister her husband and her young son, and our brother. We enjoyed our stay very much. Great to be able to sit on the dock and have coffee and read, or fish... Pat was great he stopped by to make sure we didn't need any thing but was not on top of us during our stay. the use of the pattle boat and Kanoe was fun! We all talked about how we would defenatly rent this home again if we came back and needed a place to stay. We were visiting my grand my in Greenacers WA and she loved being at the house. We had some family over one day there was about 14 of us and we had dinner on the back patio no problem! It was a great trip! Thank you Pat!!!
Great little getaway
Rob O'Malley
Great little getaway
July 29, 2013
What a view. Being able to walk down to the dock every morning an have our coffee was a treat. Nice and quiet. Pat was very accommodating and the house was exceptionally clean. Having that secluded feeling yet being only 10 minutes from downtown Coeur d'Alene was very convenient. I would recommend this place to any smaller sized groups
Ten Days in Paradise!
Anna Wood
Spokane Valley, WA
Ten Days in Paradise!
July 12, 2013
My son and his girlfriend were coming up from Texas for Hoopfest and the 4th. He wanted his girlfriend to fall in love with the Northwest. We rented this property for ten days, and I attribute her love of this area to this beautiful vacation spot. The home was lovely with many special welcoming touches. It was also fully stocked with towels, toiletries, paper products (including paper plates, cups and utinsels.) The kitchen had every needed appliance, cutting boards, silverware, cups, plates, serving platters, storage containers, you name it...it was here. The kitchen also had many cupboards to store your own groceries and items. The bedrooms were decorated with beautiful comforters and decorations and even the closets had hangers for the renters' needs. Outside on the deck was a table and chairs, and patio furniture. They had a cooler for the renter's use as well as a bbq, many trash cans, buckets with toys for kids, basketballs to use on the basketball court, etc.... The boat house was stocked with lounge chairs, life jackets, stereo system, beach toys, etc..... This place is absolutely AMAZING!!! On top of it all, the owners, Pat and Mai, were awesome! We messed up on our reservation....this was OUR problem NOT the owners...and yet they worked with us to help us out. They were understanding and helpful, when they really didn't have to be! I can't thank them enough!
Couer d"Alane Ironman basecamp
David Seger
Glendale CA
Couer d"Alane Ironman basecamp
June 28, 2013
We stayed a week around the Iron Man competition which our daughter and son-in-law ran and FINISHED! It was like we stayed with family. Pat and Mae (?) were so accommodating. The house so welcoming with all we needed for a weeks stay, including outdoor toys (Kayak!) . So many times when you stay in vacation rentals, it is bare bones. NOT HERE! It was like we never left home!! What a wonderful property!! What great folks! I hope the "kids" run another Ironman. We'll be back with friends...did I say they called to make sure we were comfortable and did I say they asked how the Ironman went? THIS PLACE...THESE FOLKS....ARE SPECIAL!!
A Great Hide-Away
Tam Collier
Bozeman, MT
A Great Hide-Away
September 13, 2012
We stayed at this sweet property for a week in late August. The host was friendly and accommodating. The property was very quiet and comfortable; all a small family could need for a relaxing vacation, with still plenty of room to entertain guests. (We had family in the area who all came and loved the place.) My husband and I had coffee every morning in the hot tub, and watched the mist rise from the river as geese flew by sounding their morning call. The boat house was stocked with water toys, and even though the rudder on the paddle boat was broken, the 2 person kayak was wonderful for paddling around the island. It was a beautiful and relaxing place that we did not want to leave. We will surely stay here again.
Memorial Day Weekend
Jyotika Diwan
United States
Memorial Day Weekend
May 30, 2012
We enjoyed staying in this home, it was truly a home away from home. Convenient to have kitchen and a BB, had an awesome time! Everything was perfect, relaxing and loved the view.
labor day weekend
labor day weekend
September 5, 2011
This was a perfect home for us, our daughters loved the private dock, paddle boat, and the kayak. The house was very clean and there was plenty of everything from bottled water, paper towles, paper plates .... We will rent it again and recomended to all my friends and everyone.
Terry Ellifritz
Wenatchee, Spokane, WA
August 8, 2011
Perfect house for our girls weekend. Everything was so clean and ready for us not to mention the extras like paddle boat, hot tub, bottled water, ice, paper products. We loved staying here!
5 Reviews
10 Reviews
85 Reviews
4 Reviews


text:
Click on a thumbnail to go to Google Books.
Jump! (edition 2010)
by Scott M. Fischer, Scott M. Fischer (Illustrator)
Work details
Jump! by Scott M. Fischer
No current Talk conversations about this book.
Children who enjoy this musical romp along the food chain may grow up to appreciate Prokofiev's Peter and the Wolf or that crazy wonderful "Food Chain" episode of Adventure Time. The audience embraces the point of view of a cartoonish animal resting content in its favorite spot until it notices a predator nearby and we all JUMP! Predator becomes prey in the next iteration of the rhythmic tale. The characters wear goofy expressions in bold watercolors that leap off the page. The repeating zoom effect of the illustrations mirrors the fluctuating intensity of the narrative.
The book was, in fact, based on a song and readily lends itself to chanting and dancing. Start each verse quiet for the sleepy animal (and use repetition to get some extra mileage out of the first line: "Well, I'm a bug, I'm a bug / I'm a snug little bug / Well, I'm a bug, I'm a bug / And I'm sleeping on this jug"). Then draw out the suspense of the approaching predator ("Untilllllllll... I see a frog and I...") before unleashing the mosh pit with "JUMP!" Use a motion, such as squatting and placing hands on the ground, to reset the quiet chant. The promise of getting to relive the suspense and release will help bring the crowd along.
One for the ukelele someday.
good for babies through preschool, very interactive, fun
25 months - a cute book. Not too wordy, more for the one year old crowd.
simple story, good rhyme, JUMP!
Read the Bilingual version.
References to this work on external resources.
Wikipedia in English
No descriptions found.
From bugs and frogs to alligators and whales, frightened animals always move out of the way of a larger opponent.
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I am so in love. Don't get to thinking \"those\" thoughts; it's not the love of matrimony and \"I do's\". It's an all-together, different type of love. I guess, it's not that different, but that's beside the point. Anyways... I'm in love with someone who doesn't love herself. How is it ever going to work? She runs to me, and then returns to those treacherous hands of Satan's spawn. I swear, there is no need for you to run, my dear. Your rays surpass those of Apollo's sun. Beauty of mine, I saw \"beauty\" because it rises like heavens from the Earth internally and externally. You are God's light: I once dreamed of you walking, and the shadow created from your light steps matched the path of God. You are a fallen angel, here on my homeland. Please raise yourself. I've so desperately tried; like a worn-out muscle, it's my time to break away and set you on your way. Find it. Don't lose me, don't lose yourself, live forever and in love with another.
© Copyright 2017 parkelis. All rights reserved.
Status: Finished
Genre: Literary Fiction
Book / Young Adult
Book / Children Stories
Poem / Romance
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This is strictly an AS-IS sale. Do Not Try to use the rear steps to the garage 2nd floor, they are unsafe. Over 2 acres of ground Great Re-Hab project. Priced to sell. Value is in the ground. Based upon the age home will most likely need a complete septic system.
Listing Area: Elk Twp
The data relating to real estate for sale on this website appears in part through the TREND Internet Data Exchange program, a voluntary cooperative exchange of property listing data between licensed real estate brokerage firms in which Callaway Henderson Sotheby's International Realty participates, and is provided by TREND through a licensing agreement and identified with the TREND IDX Logo. Some properties which appear for sale on this website may no longer be available because they are under contract, have sold or are no longer being offered for sale. Some real estate firms do not participate in IDX and their listings do not appear on this website.Some properties listed with participating firms do not appear on this website at the request of the seller.
2017 TREND, All Rights Reserved. Information Deemed Reliable But Not Guaranteed.


text:
1990 Saab 900 QuestionsRefine by vehicle
It starts cold fine. But dies (no coughing or sputtering) after it has warmed up. Will start again after waiting 4-5 minutes, but will die again shortly thereafter. Any suggestions?
Checking my oil and noticed a gas smell on the dip stick.
Just blows cold air, although the temperature is right where it should be on the gauge.
Problem happens within 10-20minutes of driving.Becomes a high pitch on freeway then a slower shuddering sound on city block streets.
When I step on brake sound goes away instantly and completely for a few minutes then reappears.At first sounds like passenger side by wheels then sounds more like center of car under the dashboard.
It's an 86' C900S and I'm looking to buy one but the ac does not work and person never attempted to fix...he said there was that the hoses were loose on the refridgeraunt and just assumed it didn't work. How should I approach this?
I don't have a user manual, so I don't know what a lot of the switches are for, even though I've used trial & error to figure them out.
I REALLY need a user manual !!
Also A/C doesn't seem to work.. Thanks, Rich
i need to know where the motor is for the convertable top.
heating problems, blowers are working but not heat just cold air in the winter and cold seasons


text:
SXSW 2009 Lineup Fully Announced.
This afternoon, SXSW unveiled its complete lineup of acts booked to play this year's festival. It's a lengthy list, and, honestly, it's kinda a bitch to troll through, unless you're looking for something specific.
So we did the dirty work for you, hunting down the complete list of DFWd acts selected to perform at this year's shindig. The good news? This year's total tops last year's of 39 acts. The bad news? It only tops it by one act, putting the DFWd number for SXSW 2009 at 40.
After the jump, the full list of locals, with links to their SXSW pages (a bunch of which, I'll warn you, haven't yet been updated with pictures and mp3s).
- Awkquarius
- Bad Sports
- Blofly
- Bosque Brown
- Bowling For Soup
- Complete
- The Crash That Took Me
- Floyd Dakil Combo
- Dooney Da Priest
- The Drams
Huelyn Duvall
Jason Eady
The Elite
- The Excels
- Fair to Midland
- Fat Pimp
- Fight Bite
- Five Times August
- Robert Gomez
- Green River Ordinance
- Here Holy Spain
- I Love Math
- Sarah Jaffe
- Little Black Dress
- Mom
- Opium Symphony
- The O's
- The Paper Chase
- Rev KM Williams and The Amazing Trainwreck
- Riverboat Gamblers
- Shibboleth
- St. Vincent
- Telegraph Canyon
- True Widow
- Tum Tum
- Jonathan Tyler and The Northern Lights
- Uptown Bums
- Money Waters
Wax Museums
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Today we take a look back at the 1992 Cannes Film Festival. Jean Claude Van Damme along with Dolph Lundgren were there to promote their new film Universal Soldier. There were plenty of rumors at that watch video >>
Part 2 of Inside MMA host Bas Rutten's interview with Dolph Lundgren. AXS TV is Your Home for MMA every Friday Night! Find AXS TV HERE: http://bit.ly/WtTUDr watch video >>
Part 1 of Inside MMA host Bas Rutten's interview with Dolph Lundgren. AXS TV is Your Home for MMA every Friday Night! Find AXS TV HERE: http://bit.ly/WtTUDr watch video >>
Friday nights are complete again! This week on Inside MMA, Tiffany Van Soest and Andrei Arlovski recap their big wins last weekend. Plus Rashad Evans talks about his return and Dolph Lundgren talks " watch video >>
After a month away, Inside MMA is BACK! Tune in Friday as Bas Rutten talks with action-star Dolph Lungren and Ron Kruck talks to Donald Cerrone. Plus Dana White stops by to preview UFC 187! Tune in a watch video >>
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text:
Focus on IELTS
By (author) Sue O'Connell
Format: Paperback
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Focus on IELTS by Sue O'Connell
Book Description* Exam Briefings and Task Approach boxes tell students what they need to know about each task type and how to tackle it * Extra grammar, vocabulary and writing practice in the end section can be used for class work or self-study * Key Language Bank provides essential reinforcement of problematic language areas * Writing Practice Bank gives guided answers and additional writing topics
Buy Focus on IELTS book by Sue O'Connell from Australia's Online Bookstore, Boomerang Books.
Book DetailsISBN: 9780582447738
(271mm x 229mm x 10mm)
Pages: 224
Imprint: Longman
Publisher: Pearson Education Limited
Publish Date: 17-Jul-2002
Country of Publication: United Kingdom
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Books By Author Sue O'Connell
Man Who Saved FC Barcelona, Paperback (July 2016)
The remarkable story of Patrick O'Connell, the former Ireland and Manchester United captain who saved Barcelona from extinction died destitute in London, where he lies in an unmarked grave.
Focus on IELTS Teacher's Book, Paperback (June 2010)
Prepare students for the IELTS exam as well as future academic study. With its focus on academic skills, this updated version of Focus on IELTS equips students for both the IELTS examination, and the tools that they need for academic life.
Focus on IELTS, Paperback (September 2006)» View all books by Sue O'Connell
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Author Biography - Sue O'Connell
Sue O'Connell has worked as a teacher and teacher trainer in Greece, Portugal and Hong Kong as well as the UK. She has been associated with the Cambridge main suite exams for many years, initially as an item writer and examiner, and later as a member of the Working Party which developed the CAE exam. More recently, she has taught and examined candidates for the IELTS tests. Sue is the author of the Focus series for Longman, to which Focus on IELTS is the latest edition, and also of Cambridge First Certificate Listening and Speaking Skills (CUP).
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text: Young Entrepreneurs Night Video: What was your 'stupidest' business mistake? Add to ... The Globe and Mail Published Wednesday, Sep. 26, 2012 4:53PM EDT Last updated Thursday, Sep. 27, 2012 7:58AM EDT Terry Brodie, senior editor of Report on Small Business, sits down with entrepreneurs Sammie Kennedy, creator and CEO of Booty Camp Fitness and Femme Fitale; Michael Hyatt, CEO and co-founder of BlueCat Networks; and Peter Fowler, CEO of SIR Corp., to discuss rapid business growth at The Globe's sixth Young Entrepreneurs Night held at PwC headquarters in Toronto Watch More Video: Video: Chilly welcome for new Trump Tower in Vancouver How Tim Hortons became part of a fast-food empire which is now adding Popeyes to its menu Milo Yiannopoulos resigns from Breitbart amid controversy U.S. firms in China change their tune on trade Trump and Trudeau launch council to promote women in business Intel announces $7-billion investment in Arizona factory Melania Trump sues Daily Mail for missed profits Nordstrom to drop Ivanka Trump's retail line Trump meets with CEOs amid tension over policies Houston hopes for big business for Super Bowl LI Uber CEO quits Trump's business advisory group Uber CEO quits Trump's business advisory group UN Eyes Complex Task of Rebuilding Syria French reporter kicked out of Le Pen campaign event Mexico business warns against U.S. walls and barriers Watch as Trump signs executive order on regulations Trump's immigration ban prompts protests and outrage Toshiba confirms sale of chip business stake Watch Trudeau be grilled on his fossil fuel stance Donald Trump signs his first executive order as president Comments Share via email Share on facebook Share on twitter Share on LinkedIn Print More Related to this Story Young Entrepreneurs Night Video: How to make your first million. Fast. Young Entrepreneurs Night Video: Be innovative. 'Don't smoke your own dope' Follow us on Twitter: @GlobeSmallBiz


text:
Sometimes, your first idea is not your best one. But you might fixate on it, especially if the idea has worked for you before. In academic terms, this phenomenon is called design fixation. In layman's terms, we might call it getting set in your ways, experiencing tunnel vision, regurgitating old ideas, or being blinded to alternatives.
As part of research published in the journal Design Studies, Nathan Crilly (who teaches engineering design at the University of Cambridge) anonymously asked 13 professional designers who work in U.K. consultancies how they deal with design fixation. These designers had an average of 21 years of experience in the field, and had plenty of ideas for getting around this common affliction. Their various approaches suggest that the tendency to get stuck on one idea, while prevalent among designers, isn't an unfixable trait.
First, here are a few things that make this fixation worse, according to these designers.
Exposure To Prior Solutions
If solutions to the problem the designers were trying to tackle already existed in the market, they found it difficult to walk the line between researching these precedents and copying older old ideas. "You've got the advantage of seeing what people have already done so that you know that these are potentially robust solutions," one interviewee said. "But then you've got the risk that you actually may have cut off some other ideas you might have come up with."
Thinking Early Ideas Are Better
"I think there quite often is a feeling that people have that they actually know the best combination of solutions pretty early on," an interviewee argued. "And most of their effort will be going to prove that that works, rather than exploring the full range of options."
Low Budgets
Thorough exploration comes at a price. Designs that take a lot of research and iterations to perfect are more expensive than firing off the first prototype you come up with, whether that comes from billing the client for extra hours or incurring the cost of delaying the product's launch. As one designer describes it:
You think of an idea. A week later you think of a better way of doing it, so you scrap the original idea. You never get anywhere. It often takes you three or four times longer to [get to] market. And the cost involved in bringing that product to market at a later date can sometimes be horrific. I don't think there is any product [of mine] where there wasn't a better way of doing it.
A Culture Of Blame
At some design firms, mistakes are a welcome part of the process. When they're not, designers can be afraid to pitch out-of-the-box ideas. "If you're allowed to make mistakes, you'll be very creative, you'll be prepared to take risks," as one designer puts it. "And if you don't have that, if there's fear there that you're going to get blamed, you won't take those risks, you won't be creative, you won't be innovative, or you'll be limited, you'll be self-limiting."
Pushy Clients
Sometimes, the clients just want what they want. It might be a concept they come up with or a sketch that the design team pitches in an early meeting. Either way, clients who fixate on a single idea place limitations on more-creative solutions.
"[Sometimes] the industrial designer shows something [to the client], and if they love that, then [the client says], 'That's what we need, that's what needs to be made.' And they're driven by that emotional feeling that that sketch or that concept produced. Usually it's because the guy that made that sketch or that concept is very good; he's also verbally [good at] presenting it," a designer observes. "And whatever you put down later, it's difficult to get them distracted from [that first idea]."
So how do you avoid getting stuck in the mud of bad first ideas?
Brainstorm And Peer Review
An isolated designer only has her own perspective to draw upon, while working in a team can bring in more outside experience. "We do peer reviews, technical peer reviews where you bring in somebody who's not related to the project to challenge you as a project leader," an interviewee explains. These outside observers can say, "'Oh, why have you done it like that?' Or: 'Show me your rationale for how you've done it.' They're acting a bit like the client, really. . . . They capture anything or they could stop [the project] before it reaches the client."
Use Morphological Charts
Morphological charts, a design tool used to generate and organize potential solutions, were the preferred method of systematically reducing the effect of fixation. "[You] build a matrix that forces you to consider all of the various different options, forces you to fill out alternative approaches," one designer describes it. "So you had to break out of that particular column you may have got stuck in."
Notice The Problem
One designer who has experience managing other employees advised taking note of a particular designer's fixation on one solution, but not letting the conversation dwell on it. "Some people will fight for their idea almost aggressively, not aggressively but quite passionately. What you have to do is usually just give it a minute, sometimes you can actually just let them have their say and move on, and just carry on going and then come back to it, just a few minutes later even, and present an alternative," that designer says. "I think it lifts up the tunnel-vision thing." Others observed that experiencing tunnel vision in a previous project helps them combat that bias in the future.
Make A Model
Sometimes, you don't know how misguided your idea was until you see it in real life, and something just doesn't work, advises one interviewee: "Typically, in a brainstorm, people fire off the immediate ideas in their head. I can imagine they would be biased by things they have seen recently or whatever, but I think when you actually come to build things, then the physics of the world kicks in, and you can't really cheat that stuff."
However, fixation wasn't always seen as a bad thing, Crilly writes:
Although a blind and unreflective adherence to a limited way of thinking was generally acknowledged as problematic, the designers also considered some aspects of fixation-related behavior to be essential to their work. This centered on recognizing an inherent contradiction: Designers must remain open to the possibility that their ideas are limited or misdirected whilst also being persistent in developing their nascent ideas in the face of negative feedback. This persistence is critical because new concepts always have problems, and some commitment to them is required unless they are to be prematurely abandoned for other concepts that will in turn prove to also have problems.
Your first few solutions may not be the best, but at some point, you do have to stop brainstorming and start building. Just don't be afraid to make a few things that suck, first.


text:
Cytosolic phospholipase A2α mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice
© The Author(s) 2010
Received: 30 October 2009
Accepted: 29 April 2010
Published: 29 April 2010
Lungs of cystic fibrosis (CF) patients are chronically infected with Pseudomonas aeruginosa. Increased airway constriction has been reported in CF patients but underplaying mechanisms have not been elucidated. Aim: to examine the effect of P. aeruginosa LPS on airway constriction in CF mice and the implication in this process of cytosolic phospholipase A2α (cPLA2α), an enzyme involved in arachidonic acid (AA) release.
Mice were instilled intra-nasally with LPS. Airway constriction was assessed using barometric plethysmograph. MIP-2, prostaglandin E2 (PGE2), leukotrienes and AA concentrations were measured in BALF using standard kits and gas chromatography.
LPS induced enhanced airway constriction and AA release in BALF of CF compared to littermate mice. This was accompanied by increased levels of PGE2, but not those of leukotrienes. However, airway neutrophil influx and MIP-2 production remained similar in both mouse strains. The cPLA2α inhibitor arachidonyl trifluoro-methyl-ketone (ATK), but not aspirin which inhibit PGE2 synthesis, reduced LPS-induced airway constriction. LPS induced lower airway constriction and PGE2 production in cPLA2α -/- mice compared to corresponding littermates. Neither aspirin nor ATK interfered with LPS-induced airway neutrophil influx or MIP-2 production.
CF mice develop enhanced airway constriction through a cPLA2α-dependent mechanism. Airway inflammation is dissociated from airway constriction in this model. cPLA2α may represent a suitable target for therapeutic intervention in CF. Attenuation of airway constriction by cPLA2α inhibitors may help to ameliorate the clinical status of CF patients.
Cystic fibrosis (CF) is the most common recessively inherited disorder in Caucasian population (1 on 2500 births) [1, 2]. This disease is due to mutations in the CF transmembrane conductance regulator gene [CFTR]. The protein product of CFTR is a chloride channel expressed in epithelial cells where it regulates the luminal secretion of chloride and water transport to keep the homeostasis of mucillary clearance. Mutations of CFTR lead to dysfunction of chloride and sodium channels, and as a consequence to airway mucus dehydration and hypersecretion. This leads to airway obstruction, chronic bacterial infection by Pseudomonas aeruginosa, and inflammation, which result in a dramatic respiratory insufficiency. These pulmonary complications are the most leading cause of mortality in CF patients. In addition to these manifestations, increased airway constriction was reported in CF patients. Airway constriction is a common feature in CF patients that seems to be exacerbated with age, although the underlying mechanism is not known [3]. Pioneer clinical studies revealed increased levels of prostaglandins (PGs) and leukotrienes (LTs) in broncho-alveolar lavage fluids (BALF) of CF patients [4]. PGs and LTs are metabolites of arachidonic acid (AA) that is released by cytosolic phospholipase A2α (cPLA2α) [5, 6]. This enzyme has been shown to play a role in various animal models of lung inflammatory diseases including induction of airway resistance in response to allergic challenge [7, 8].
Taken together these findings led us to postulate that P aeruginosa LPS induces airway constriction in CF through an activation of AA metabolism. Since the discovery of the gene responsible for CF disease, a number of CFTR gene-targeted mouse models, such as CFTR -/- mice [9], were generated to investigate the pathophysiology of this disease. In the present study, we investigated the effect of P. aeruginosa LPS on airway constriction using CFTR -/- mice. Our results showed that LPS induced exacerbated airway constriction in CFTR -/- mice compared to littermate and that cPLA2α plays a key role in this process. In addition, cPLA2α induced airway constriction occurs independently from lung inflammation. The molecular mechanisms underlying airway constriction in CFTR -/- mice and their pathophysiological relevance in CF are discussed.
Materials and methods
Animals and reagents
CFTR-null mice (C57BL/6J Cftrm1UNC), established by gene targeting [9] were obtained from the "CDTA" UPS44 CNRS (Orleans, France). Wild type and mutant littermates were fed together by the mother until 3-4 weeks of age. CFTR-/- mice typically die shortly after weaning from intestinal obstruction. In order to increase the survival of these mice, we used a commercial osmotic laxative (Movicol®) which was provided continuously in the drinking water [10]. Both CFTR-/- and littermates mice received Movicol. Experiments were performed on 8-9 week-old mice.
cPLA2α-null mice were established by gene targeting as described previously [8]. Mice heterozygous for a cPLA2α mutant allele with the genetic background of the C57BL/Ola hybrid were mated. Animals were fed a standard laboratory diet and water ad libitum. Eight to 9 week-old mutant homozygous mice (cPLA2α -/-) and their homozygous control littermates (cPLA2α +/+) were used in this study. The protocol for animal studies were reviewed and approved by the Institute Pasteur Animal Care and Use committee in accordance with French and European guideline.
According to the experiment of Penh measurement, animals (both CFTR and cPLA2) were divided into 4 groups including saline/wild type, saline/knock-out, LPS/wild type and LPS/knock-out (n ≥ 6 for each group). Airway constriction (Penh) was monitored before and after LPS/saline instillation as detailed below. In separate groups of mice as described above (n ≥ 6 for each group), 24 h after LPS/saline treatment, cells counts in bronchoalveolar lavage fluids were determined, eicosanoid acid and cytokine were also measured. In certain experiments, total RNA was extracted from lungs of treated animals 24 h later.
LPS and drug instillation
Mice were slightly anesthetized with ether. Anesthetized mice received intra-nasal instillation of 330 μg/kg of P. aeruginosa LPS (serotype 10; Sigma, St. Louis, MO) or equivalent volume of saline. In certain experiments, ATK (20 mg/kg) or aspirin (50 mg/kg) was injected intra-peritoneally 1 h before LPS challenge. The dose and route of administration of ATK and aspirin used in the present study were adopted from previous reports [11, 12].
Measurement of airway constriction
Airway constriction was assessed in conscious and freely moving mice using whole-body barometric plethysmography (Buxco Electronics, USA) according to the manufacturer's instructions and previous reports [9, 13–15]. In brief, each animal was placed in a main chamber and the pressure difference between this and a reference chamber was measured with a differential pressure transducer connected to amplifier and recorded with BioSystem XA analyzer software (Buxco Electronics, Birmingham, U.K.). Airway constriction expressed as enhanced pause (Penh) was calculated as follows: Penh = (Te - Tr)/Tr(PEP/PIP), where Te is the expiratory time (seconds), Tr is the relaxation time (time of the pressure decay to 36% of total box pressure at expiration), PEP is the peak expiratory pressure (milliliters per second), and PIP is the peak inspiratory pressure (milliliters per second).
BALF and cell counts
Twenty-four hours after LPS or saline challenge, mice were anesthetized with pentobarbital (i.p.) and the trachea was incised and cannulated. BALF were collected with saline (4 × 0.5 ml) and total cell counts were determined using a Coulter counter (Coulter-Electronics, Margency, France) as well as a Diff-Quik staining (Baxter-Dale, Dudingen, Germany) of cytospin slides for cell differential counts. Results are expressed as the number of various cell populations per ml.
Cytokine and eicosanoid assays
PGE2, LTB4 and cysteinyl-leukotrienes (LTC4/D4/E4) concentrations were measured using enzyme immunoassay from Cayman Chemical Co (USA). The cytokine MIP2 was measured with a Kit DuoSet ELISA (R&D Systems).
Analysis of free AA
BALF samples were extracted by a mixture of chloroform, methanol and water (4:2:1, v/v) in the presence of 15 μg of heptadecanoic acid (internal standard). After vortex and centrifugation at 800 g for 5 min, the chloroform phase was collected and dried under a nitrogen stream. Then, fatty acids were methylated and quantified by gas chromatography-mass spectrometry with the use of a gas chromatograph as previously reported [16].
RNA extraction and quantitative PCR
The primer sequence and PCR annealing temperature of quantitative PCR.
Forward primer
Reverse primer
Annealing Tm (°C)
Statistical analysis
Data are expressed as means ± sem of at least 6 mice in each group. Statistical analysis was performed using either unpaired Student's t test or ANOVA test for multiple groups using SPSS software and p value less than 0.05 is considered as significant.
Enhanced airway constriction in LPS-treated CFTR -/- mice
Airway inflammation is not different in CFTR -/- versus CFTR +/+ mice
Increased AA and PGE2 levels in BALF of CFTR -/- mice
A role for cPLA2α in LPS-induced airway constriction in CFTR -/- mice
We also studied whether the cPLA2α/COX pathway play a role in LPS-induced neutrophil recruitment and MIP-2 production. No significant differences were observed between cPLA2α -/- and cPLA2α +/+ mice (data not shown). This was supported by the fact that instillation of ATK or aspirin had no effect on these inflammatory parameters neither before nor after LPS challenge (data not shown).
We report here that CFTR -/- mice develop an exacerbated airway constriction in response to LPS as compared to their corresponding littermates, which is in agreement with observations made in CF patients [3]. In addition to exacerbated pulmonary inflammation, CF patients manifest airway obstruction and wheezing [20] and near 40-50% of these patients have airway constriction. This led us to explore the mediators involved in the induction of airway constriction in CFTR -/- mice. Our studies suggest that cPLA2α, which catalyzes the key step of AA release, plays a role in enhanced airway constriction observed in CFTR -/- mice. Indeed, we found an increased concentration of AA in BALF from CFTR -/- vs CFTR +/+ mice. Our findings are in agreement with the pioneer work of Uozumi et al. reporting that cPLA2α plays a key role in increased airway resistance in response to allergic challenge [8]. Concerning the mechanism by which CFTR regulates cPLA2α, recent studies in our laboratory suggested that cPLA2α activity is inhibited by CFTR through a protein-protein interaction [[21], unpublished data (Dif F, Wu YZ)]. The absence of CFTR or its F508del mutation (known to promote CFTR degradation) may increase cPLA2α activity by the removal of the CFTR inhibitory effect.
In the present study both cPLA2α null mutation and pharmacological inhibition by the cPLA2α inhibitor, ATK, reduced LPS-induced airway constriction in CFTR -/- mice. This identifies cPLA2α as a key factor in LPS-induced airway constriction in CFTR -/- mice. However, we cannot exclude the contribution of another PLA2, iPLA2, to this process. Indeed, ATK has been shown to interfere with iPLA2 activity [22, 23].
Our findings that the COX metabolites of AA did not contribute to LPS-induced airway constriction in CF animal model are in agreement with the previous studies of Vincent et al [24] which showed that aspirin fails to interfere with LPS-induced airway constriction in guinea pig. Aspirin did not interfere with LPS-induced airway constriction in mice and blockade of COX-2 activity by the specific inhibitor NS-398 only delayed this airway constriction [25]. In the present study we only investigated PGE2 levels since other studies have shown an increased production of various PGs including PGF1, PGF2α in BALF of LPS-treated CFTR -/- mice compared to their littermates [26]. Because aspirin is known to suppress the production of all PGs produced either by COX-1 and COX-2 pathways, we can conclude that PGs are not involved in LPS-induced airway constriction in CFTR -/- mice.
On the other hand, our findings suggest that 5-LOX, a major LOX pathway of AA metabolism is unlikely to be involved in LPS-induced airway constriction. Indeed, the levels of LTB4 and cysteinyl-leukotrienes (LTC4/D4/E4), the products of AA via LOX, are similar in CFTR-/- compared to CFTR +/+ mice. However, we cannot exclude that other LOX-dependent metabolites such as those of 12-LOX can play a role in airway constriction. Indeed, the expression level of this LOX has been shown to increase in bronchial tissues of CF patients [27].
Our studies suggest that increased PGE2 production in CFTR -/- mice may result, at least in part, from the availability of higher concentrations of free AA. This is in agreement with previous studies reporting that epithelial cells from CF patients release more AA than control cells and express higher levels of cPLA2α activity [28–30]. The fact that CFTR -/- and CFTR +/+ mice produce comparable levels of LTB4 and cysteinyl-leukotrienes is paradoxical given the enhanced production of free AA in BALF of CFTR -/- mice. Although the reasons for this paradoxical observation are still unclear, we suggest that a metabolic deviation of AA in favor of COX pathways may occur in lung tissues of CFTR -/- mice. This might be due to an enhanced activity of COX enzymes in spite of similar expression levels in lungs from CFTR -/- and CFTR +/+ mice. It is also likely that the activity of PGE synthase (PGES), which produces PGE2 from PGH2, may increase in lungs of CFTR -/- mice. Thus, in addition to changes in AA levels and cPLAa activity, an increased PGES activity could be a possible interpretation of PGE2 elevation in CFTR -/- mice.
Failure to detect changes in leukotriene levels in CFTR -/- mice is also in disagreement with the previously reported high LTB4 levels in BALF of CF patients compared to healthy subjects [4]. This discrepancy might be due to differences in the expression levels of LOX, COX and PGES in CF patients compared to CF mice. Previous findings [31] reported an exacerbated expression of COX-2 in epithelial cells and nasal polyps from CF patients as compared to the corresponding controls [31]. Whether this discrepancy is due to differences in animal species or cell types involved in COX expression remains to be investigated. It remains also unclear whether COX-2 up-regulation observed in polyps from CF patients is a direct consequence of CFTR mutation and/or a secondary consequence of airway inflammation and infection inherent to CF disease.
Although the molecular mechanisms involved in cPLA2α-induced airway constriction in LPS-challenged mice are still unclear it is likely that airway smooth muscle cells (SMC) may play a role in this process. In the asthmatic airway, acute airway constriction is caused, in part, by the enhanced presence of mediators released from inflammatory cells that directly induce bronchoconstriction and enhance bronchoconstrictor responses to other agonists. Airway obstruction and airway constriction in CF patients coincide with those seen in asthma and suggest that airway SMC remodeling may contribute to lung pathology in CF [32]. Recent studies reported that accumulation and/or hypertrophy of airway SMCs contribute to airway narrowing and airway constriction in CF patients [32, 33]. A previous study showed that bradykinin-induced contraction of airway SMC occurs, in part, via a process involving a rise of [Ca2+] and enhanced release of AA [34]. More recently, it has been shown that the AA metabolite 20-HETE induces sustained contraction of isolated guinea pig airway SMC [35]. Interestingly, a recent study demonstrated that CFTR is also expressed in tracheal SMC and may contribute to bronchodilation [36]. Thus, it is likely that enhanced airway constriction in CFTR-/- mice might partially be due to the lack of bronchodilation function of CFTR in tracheal SMC. On the other hand, morphological analysis of the trachea and airway functional studies showed the presence of disrupted or incomplete cartilage rings in trachea of both adult and newborn CFTR -/- and F508del mice [37]. Although the loss of tracheal cartilage may predispose to collapse of the airways, the possible relationship between congenital malformations in CF mice and airway constriction remain to be investigated.
Our studies showed that although LPS induces airway constriction in CFTR-/- and cPLA2α +/+ mice at different intensity as compared to CFTR+/+ cPLA2α -/- mice, respectively, all mouse strains develop a similar extent of lung inflammation in term of neutrophil influx and MIP-2 production. This can be explained by the fact that cPLA2α may not play a role in lung inflammation in LPS challenged mice. It is also likely that PGE2 plays a role in attenuating lung inflammation in CFTR -/- mice since this prostaglandin is well known to exert an anti-inflammatory effect in lungs [38]. Thus, the enhanced production of PGE2 in CFTR -/- mice may explain, at least in part, why these mice do not exhibit exacerbated lung inflammation. The fact that airway constriction occurs independently from lung inflammation is in agreement with previous reports. Indeed, Lefort et al. showed that airway constriction occurs independently of pulmonary neutrophil recruitment or TNFα synthesis [39]. A similar report showed that increased airway constriction induced by inhaled LPS in COX-1 -/- and COX-2 -/- mice is dissociated from airway inflammation [15].
LPS induces exacerbated airway constriction in CFTR -/- mice, which occurs through a cPLA2α-dependent mechanism and is dissociated from airway neutrophil influx and MIP-2 production. cPLA2α may represent a suitable new target for therapeutic intervention in CF.
cystic fibrosis transmembrane conductance regulator
prostaglandin E2
broncho-alveolar lavage fluids
arachidonic acid
- cPLA2α:
cytosolic phospholipase A2
leukotriene B4
arachidonyl trifluoro-methyl-ketone
- Penh:
enhanced pause
smooth muscle cells
this work was supported by the French association "Vaincre la Mucoviscidose" and the Foundation Legs Poix, Paris.
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text: Report: A-Rod Refuses To Give Bosch Money; Bosch Cuts Deal With MLBSean Newell6/06/13 1:37amFiled to: Biogenesisanthony boschalex rodriguezmajor league baseballnewssportsmlbnew york yankees411EditPromoteShare to KinjaToggle Conversation toolsGo to permalink According to the New York Daily News, Anthony Bosch tried to get money from A-Rod to help pay his mounting legal bills, due in part to the frivolous lawsuit filed by Major League Baseball for tortious interference. A-Rod refused his request, so Bosch cut a deal that would end the lawsuit and require MLB to indemnify him from the collateral damage his cooperation would cause. The Daily News reported Wednesday that baseball was concerned Bosch might turn to players for financial help if MLB didn't lock him into an agreement to testify."They were afraid someone else would pay him," said the source. "Bosch is the only guy that can provide them with what they need."Bosch is expected to provide MLB with enough dirt to suspend Rodriguez and nearly two dozen other players, sources familiar with the Biogenesis case have told The News, including Milwaukee Brewers outfielder Ryan Braun, who has had a target on his back since he successfully appealed a positive drug test last year.Among the benefits Bosch will reportedly get for his cooperation is Baseball's intervention in any potential legal actions from the various law enforcement organizations who might be interested in what he has to say when he sings about all the performance enhancing drugs he provided players. Advertisement Advertisement So here's Major League Baseball—doggedly hunting down so-called cheats and players who have been demonized because of their association with a fountain-of-youth charlatan—bankrolling the guy even those same cheats won't help. What's that they say about the company you keep?Photo credit: GettyYankees' Alex Rodriguez refuses to pay Anthony Bosch, who then cuts deal to help MLB [NY Daily News]Reply41 repliesLeave a reply


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The Peace and Conflict Studies Minor provides an interdisciplinary study of peace, war, international relations, and conflict resolution. It is designed for those interested in careers in adventure education, conflict resolution, management, public relations, organization work, and social work. The minor is designed to build analytical skills that can be applied to a range of situations. Specifically, students will become more familiar with positive and negative peace, nationalism, nation building, globalization, and conflict resolution strategies including negotiation and mediation.
View the Course Requirements
New Peace and Conflict Studies Curriculum for Fall 2016: Following the campus-wide curriculm redesign for many majors and the credit change for all classes, the Peace Studies Minor has undergone some positive redesign (see "courses" link to the left)
FLC Peace 101 Students spend Thanksgiving Break at Black Mesa, continuing a project from PEAC 401
FLC PEAC 101 students Rachel Giersch, Breet Sherman, and Jaylen Terry produce a song based on the injustices of Black Mesa. Listen here.
On Veterans Day, Peace and Conflict Studies screens Frame by Frame and hosts a discussion by Peace minor graduate and veteran Michael Long.
FLC Peace and Conflict Studies now hosts Peace Studies Journal.
Join us for Hip Hop for social justice
The Water Justice Project--a PEAC 401 product--has a successful Animas River cleanup!
Peace 401 students present their work on Black Mesa at the 2015 Notre Dame Student Peace Conference
Sister Helen Prejean visits with PEAC 101 students on 10/21 to discuss the death penalty and social activism.
Albert Einstein Institute Executive Director Jamila Raqib visits with PEAC 101 students on 10/2 to discuss methods of nonviolent action. Hear an interview with her.
Peace scholar David Cortright to visit FLC in March. He will visit PEAC 401 on 3/6, speak at Life-Long Learning series on 3/6 at 7 pm, and visit Sociology classes on Friday 3/7.
KDUR radio show documents work of FLC faculty engaged in activism and ending structural violence. Listen here: KDUR Making a Difference
Myanmar expert Priscilla Clapp visits PEAC 101 class on 10/3. See her report on Sustaining Myanmar's Transition.
PEAC Minor students host fundraiser/silent auction for orphanage in Tanzania: Friday 2/22 from 6-9 pm at the DSNGRR Train Museum.
Notre Dame faculty member Dr. Larissa Fast visits PEAC 101 to present on NGO security
Three former PEAC 401 students discuss NGO work in Tanzania on KDUR
Community Conversations hosts fire panel and discussion at concert hall. Click here for notes.
July 4th Durango Herald article discusses positive peace and Gandhi in the FLC peace minor.
FLC faculty Drs. Erik Juergensmeyer, Pete McCormick, and Bill Mangrum attend Notre Dame Kroc Institute for Teaching Peace in the 21st Century
Two former PEAC 401 students get summer employment as grant writers after strong semester project
Three former PEAC 401 students go to Africa to work for an orphanage
John Paul Lederach visits campus to speak on social healing and meet with PEAC students.. To see his entire presentation, click here.


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This is an International Magazine, please allow up to ten to twelve weeks for your first delivery.
Delivery is direct from the publisher and is only available for delivery within Australia.
ELLE RUSSIA : As with its English counterpart, the russian edition of Elle magazine focuses on the world of fashion, beauty, & style. Please allow 10-12 weeks for delivery of the first issue for this international title.
Barcode: 6000000032710
Format: Magazine Subscription
Language: English
Number of Issues: 12
Subscription Length: 12 months


text: Former Assassin's Creed Boss Explains His Move to THQPatrice Désilets10/19/10 9:00am2301EditPromoteGo to permalink Earlier this morning THQ confirmed that Patrice Désilets, the former creative director behind Ubisoft's Assassin's Creed series, was forming a new studio in Montreal for them. Désilets emailed an open letter to Kotaku to explain why. - Ed.


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We are a voluntary aided primary school with 78 pupils situated in the village of West Ashton, overlooking the beautiful west Wiltshire countryside and the county town of Trowbridge. We seek to provide the highest educational standards in the context of the Christian faith upon which our school was founded 170 years ago. We are extremely proud of our school and of the warm and caring family atmosphere that we have. Everybody is valued at West Ashton and everybody takes part.
Our Motto is 'Discovering, achieving and praying together.'
We discover new ideas, opportunities and skills everyday; we achieve our goals whether they be academic, sporting or artistic and we respect our Christian foundation through our prayer. We do these things together as a family would; the parish family, the faith family, sporting family, artistic family or the human race family.
We value kindness, respect, peace and friendship!
Go to our governors section in about us to see what we are working on to improve our school.
We hope you enjoy our website. If you do not find the information you require please do call Judy or Tracy in the office and they will be happy to help.


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Stone Bridge Valley Art Center
The Stone Bridge Valley Art Studio is a place to explore the various media available and enjoy the company of others. It's a place to display or sell art and now includes a Gallery Boutique, classes and a working studio.
Eaton Studio & Gallery exhibits and sells the work of local artist Herb Eaton in a 1902 historic building in downtown Bloomington. The paintings, sculptures and drawings reflect the artist's interest in the local rivers, cornfields, gardens, circus, and music scenes. The Gallery hosts art salons, jazz and acoustic musical and theatrical events and sponsors cultural discussions focused on local community interests. Open most Saturdays 10am-2pm, by appointment, special events, and during 1st Fridays 5-8pm.
Accessible Art Gallery supports the arts, with an emphasis on the visual, through the provision of a venue for promoting, exhibiting, experiencing, marketing and creating diverse, high quality art and through participation in the local community.
Established in April of 2008, Main Gallery 404 provides downtown location for many local artists to display and sell fine artwork and gifts. The Bloomington-Normal area is rich with talented artists. MG 404 gives these artists the much needed opportunity to make his or her work visible
Artful Designs is Bloomington's original and only 'paint your own' pottery studio. It offers the area's largest selection of ready-to-paint pottery. Personal attention and design expertise are available to customers who wish to paint their own pieces. Custom pottery, painted by Artful Designs' talented, experienced staff is also available.
Sugar Grove Nature Center is located in beautiful, historic Funks Grove among over 1,000 acres of forest and prairie. Funks Grove is the largest remaining intact prairie grove in the state of Illinois and is a designated National Natural Landmark. Visitors will enjoy interpretive exhibits, live animals and a wildlife viewing room as well as access to 5 miles of hiking trails. The Imagination Grove Nature Play Area welcomes children to explore, tromp in the creek, climb a tree, ride a zip line and more. A picnic shelter, astronomy observatory, blacksmith forge, corn crib prairie lookout, variety of gardens and many other features help to make Sugar Grove Nature Center a beautiful and unique place. Visit the website to learn more about special events and programs.
At Merlot and a Masterpiece you will find a casual, fun, creative environment where you can relax, imagine, create, laugh and go home with memorable and unique canvas art! Our fun and carefree instructors will facilitate the class and guide you in creating your own work of art. At Merlot and a Masterpiece you will find a casual, fun, creative environment where you can relax, imagine, create, laugh and go home with memorable and unique canvas art! Our fun and carefree instructors will facilitate the class and guide you in creating your own work of art.
Celebrating regional art in its many forms: special exhibits, performances, regional artwork gallery, photography from the historic Alfie Mueller collection.
Northern Illinois University Art Museum
NIU Art Museum's mission is to service the arts curriculum at NIU and to extend arts education and cultural enrichment to the community. The Museum has a permanent collection of 1,000 art pieces and also hosts visiting exhibitions. The Jack Olson Gallery is "the cornerstone of exhibition programming" that is promoted by NIU School of Art. This exhibit space brings thought provoking exhibitions to the northern Illinois community while also offering faculty and students a space to showcase their latest creative endeavors.
Three floors of fun! Shop our 1st floor boutique, create in our upstairs art studio and upcycle with vintage soul re-sale in our lower level.
Illinois State Museum-Southern Illinois Art Gallery
A museum gallery featuring theme-based exhibits of works created by past and contemporary Illinois artist and artisans. Less than 1 mile southeast of Rend Lake.
If These Walls Could Talk in Downtown Aurora not only provides 100% archival quality framing services their shop acts as an art gallery for visitors to enjoy, buy, and sell their art. A regular venue for Downtown Aurora's First Friday event.
Art Attack offers a variety of classes, hosts private events, and has an artist gallery for viewing. Art Attack is a place for empowering self-expression and freedom through art.
Country gift shop, collectibles, pictures, Pipka Lizzi High dolls, Santa's Pat Richter pictures, year-round holiday room, and Yankee candles.
Quilting supplies, over 3000 bolts of material for quilting. Authorized Husqvarna Viking sewing machines.
A variety of classes for children and adults, including private event painting sessions for birthday parties, girls night out, corporate events, team building, bachelorette parties and baby showers.
Visit Chicago's largest visual arts center. Founded in 1975, Lillstreet Art Center is a large community of artists and students working side-by-side in a friendly environment, which encourages and inspires artistic growth in the individual. Our center on Ravenswood Ave., boasts state-of-art equipment and more than 800 art classes and workshops to choose from each year. We support the arts through educational classes for adults and youth, an artist-in-residency program, a gallery with local and national work, studio space, an outreach program, and an arts-based professional development program. Join us for free events throughout the year such as, open houses, art fairs, and gallery receptions or stop by anytime to browse our unique artisan gift shop and have a bite in the café.
Culture Stock is a social venture that operates as a hub for cultural activities and community programs while serving as a used book and media re-seller. Culture Stock, located in the heart of Downtown Aurora, offers up-and-coming musicians, poets and other artists a place to display their talents. Stop in for a taste of Aurora's culture, read a good book in a cozy corner, listen to a new performer or join a language circle. Kids have events at Culture Stock too. Check their Facebook page for a Downtown Aurora cultural experience update today!
Peruse fair trade personal accessories, home decor, gifts, coffees, chocolates, and more for one of Oak Park's most unique shopping experiences. Ten Thousand Villages is dedicated to providing necessary and fair income to artisans in developing countries by publicizing their handicrafts and bringing a personal touch by telling their stories.
CITY:Oak Park
One of the best Japanese art galleries in the world outside of Japan. Elias Martin's knowledge and passion will educate you and amaze you. A must see in Chicago. Established in 1987, specializes in Japanese fine art with a focus on 20th century woodblock prints by Shin Hanga and Sosaku Hanga artists.
The Paderewski and Kosciuszko memorial rooms, folk art, photos and documents all tell the fascinating history of the Polish immigration to America and Chicago, where the largest Polish population outside of Warsaw resides.
Historic home with five rooms plus a garden area crafts, used furniture, candles, nick knacks, flavored coffees, old plows, wheel barrel and more. "Five rooms to browse".
CITY:Mount Olive
Located one block off Main in Oblong, Henpeck features Painted Cabinets, birdhouses, curtains, candles and all weather baskets.
Country home furnishings. Candles, cooking ingredients, pictures. Enjoy our coffee of the day while you shop.


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Medieval England: The Manor
This is a fascinating video with fun illustrations and a great narrator. It reminds us…
Sure, these are traditionally eaten on Good Friday, but the sweet, tasty little buns are so darling that there's no reason you shouldn't eat them on Easter as well–or in September for that matter.
I've always been in love with the name "hot cross bun". It just sounds so quintessentially English and makes me think of Beatrix Potter. These sticky, spicy treats are best known for their distinctive cross shape (cut into the top of the bun, traced in icing or a floury paste, or made with strips of pastry) that symbolizes the cross that Jesus Christ was crucified on. It is a yeast bread studded with dried fruit and covered in a shiny glaze.
|Hot Cross Buns, a photo by garryknight on Flickr.
Some speculate that the hot cross bun reaches back to ancient Babylonian goddess-worship (a far-flung surmise, in my opinion), or Saxon fertility rites, and others will go so far as to attribute them to the Aztecs. But the first recorded use of the term "cross bun" is English, and doesn't occur until 1733 (they weren't called "hot" until the 19th century), so it's likely that they are exactly what they purport to be–an English, Christian baked good.
|Jan 29/12 Homemade Hot Cross Buns, a photo by Jude Doyland on Flickr.
According to PracticallyEdible.com, there is a great deal of lore surrounding these humble buns.
So enough of history and literature, let's get to the yeasty bit.
There's a recipe at WildYeastBlog.com for traditional hot cross buns. This involves a pre-prepared yeast starter which you might find more trouble than it's worth. In that case, check out this recipe from JoyOfBaking.com for the buns made in this video. And, if you're the kind who'd rather salivate over photos than actually get your fingers dirty, you have to check out ThePioneerWoman.com to see her gorgeous food photography.
First Photo: Konditor Easter is coming, a photo by Ambernectar 13 on Flickr.
"Like" Picture Britain on Facebook for exclusive links, photos, and information! http://www.facebook.com/PictureBritain


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Good value, comfortable shoe, delivered quickly with no problems.Date Added: 02/18/2015 by Brian Chaney
Arrived way before due date. Very impressed with service. These slippers are very comfy and it does not make any difference that they are men's slippers.I have problem feet and these slippers are great....Date Added: 02/17/2015 by Angie Barker
The most recent of many purchases from Wynsors and as, expected are exactly what I wanted. Comfortable, smart and well made....Date Added: 02/17/2015 by Colin Spicer


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Residents can take part in recreational activities with the community features we offer. Amenities include a sparkling swimming pool, sauna, BBQ area, recreation room, and a state-of-the-art fitness center. Our warm and inviting community welcomes cats as well. Rent range: $1395 - $1550 More details (copy link to browser) http://ah.qa/8QMdb2M → Read More
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Build your personal cloud services
Own the Cloud: Set up your own personal cloud server with ownCloud.
Moving your data and applications to the cloud seems like a great solution to many problems. You can access your files and documents from any device connected to the Internet, sync data between multiple machines, and stay productive while on the move. A myriad of third-party cloud-based services would be happy to store your data and give you access to their web-based applications for a monthly or yearly fee, but this approach raises another set of security and privacy issues. Besides, third party services come and go. Even the most well-established cloud services that seem too big and popular to fail could fade away with time. In theory, you should be able to get your data back, but things don't always work out in practice. Even if you manage to get a hold of your documents and files, migrating to another cloud-based service can be both time consuming and expensive.
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Munich Plans to Ditch Linux and Go Back to Windows
A major setback for the Linux desktop.
Linux Kernel 4.10 Comes with New Security Features
Improved support for GPU in virtualization.
OpenSUSE Site Hacked
News site for the openSUSE community falls victim to a Wordpress exploit.
LibreOffice Goes Online with 5.3 Release
The source code is available online.
Microsoft Brings Clear Linux OS to Azure
One out of three virtual machines on Microsoft Azure Cloud run Linux.
ASUS Announces a Single-Board Computer
The form factor of the board makes it a drop-in replacement for Raspberry Pi.
Red Hat Releases RHEL 6.9 Beta
Makes it easier for customers to move workloads into container-centric applications.
SUSE Working on a New Operating System Called MicroOS
SUSE's answer to container-centric operating systems.
Biggest Kernel Release Ever
Linux 4.9 is the biggest release in terms of number of commits.
CentOS Linux 7 (1611) Released
The latest version of the official RHEL clone is here.


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New Ford Transit nets 5-star safety scoreComments Email
DEARBORN, Mich. (April 9, 2014) — The 2014 Ford Transit Connect Wagon has earned a five-star overall vehicle score from the National Highway Traffic Safety Administration (NHTSA), the government's highest possible overall rating.
Last year, the European version of Transit Connect Wagon, known as Tourneo Connect, earned a five-star rating from the European New Car Assessment Program, the highest possible score from the consumer advocacy group.
The Transit Connect Wagon, available in five-passenger and seven-passenger versions in North America, became available earlier this year.
Transit Connect Wagon's driver and passengers are protected by its body structure, more than half of which is built with high-strength and ultrahigh-strength steels, including 16-percent boron steel, according to Ford. The vehicle features driver and passenger side airbags for front-row occupants, as well as side curtain airbags for all seating rows.
The vehicle also has driver-assist features such as a rear-view camera and forward- and rear-sensing systems.
A story from the March 31 edition of Tire Business pointed out that the major auto makers' new global vans, often referred to as "Euro vans," feature extended roof heights and multiple wheelbases, which yield larger cargo space than the typical commercial van American consumers are familiar with.
However, while this widespread change brings with it measurable advances in efficiency and cargo flexibility, it also introduces potential problems in tires in terms of product availability and load-range issues, since most of the new vans are fitted at OE with higher load-range "C"-spec, or European-spec tires.
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north face outlet berkeley hours too many kids who are over-protected. You have got to stretch these kids to just outside their comfort zone."Grandin's talk, which was broadly about "Different Kinds of Minds," one of the themes of her latest book on autism, "The Autistic Brain," ranged from the stupid mistake at Japan's Fukushima Nuclear Power Plant (they put critical emergency equipment into a non-water-proof basement at the plant, which is on the edge of the sea) to how not every kid can or should take algebra."We need different kinds of minds working together," Grandin said, in the lecture that was illustrated with pictures for each point. "Schools are going crazy right n
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