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The boxing ring is the ultimate playground of lies. It is there where weak smiles and sweating eyes mask trepidation, the armour needed to endure sport's cruellest examination. But fighters can only carry off this necessary deception for so long.
On the night of 2 May 2009, in the MGM Grand Arena in Las Vegas, Manny Pacquiao took a second under six minutes to acquaint Ricky Hatton with a truth he could no longer avoid. His fighting days were over. One final punch to go with the thousands he had absorbed during 12 years as a professional boxer was all it took. There followed a cocaine-driven spiral that this emotional and sensitive man only now has come to terms with, a nose dive of the most literal kind.
Yet nearly two years since he last visited that beguiling battleground, with chilling consequences, people close to the former world champion are still trying to get him to fight again.
Those who care about Hatton's physical and mental health should be angry with Oscar de la Hoya, Ricky's supposed good friend who, as his business partner, is the loudest voice urging him to make what would be a doomed comeback. First came reports that another fine old pug with more misplaced ambition than sense, Erik Morales, wanted to fight Hatton – an event that would add at least £2.4m to the Mancunian's bank account, and a good deal more to De la Hoya's, whose Golden Boy Promotions is now the financial engine of professional boxing.
De la Hoya's reaction was indecently swift and ill-considered: "Ricky against Morales would be a wonderful fight in Las Vegas, a great event, a meeting of two real legends of the sport. Fight fans all over the world will want to see that."
The unconvincing evidence for such a spurious claim was the Mexican's spirited losing effort this month in Las Vegas against Marcos Maidana, the Argentinian whom Amir Khan had battered in the same town four months ago. Morales is 34 and carries a tell‑tale ripple of immovable flab just above his waistband.
Only a few days before his offer to Hatton, however, the one‑time Hitman said: "I haven't coped well with retiring, but you have to hit rock bottom before you get back into gear – which is what I've done. It still breaks my heart to think I won't fight again, but at least I'm man enough to admit it now." His father, Ray, and his solicitor, Gareth Williams, later confirmed there had been an offer. No decision had been made, as if there could be more than one.
All of this prompts the suspicion that De la Hoya is as avaricious as any other promoter and, in that role, he has a large measure of control over two of Britain's four world champions, Khan and David Haye. They are grateful for his business expertise – but they are young and at the peak of their powers.
To be anointed by the Golden Boy is to wonder at the power of impossibly white teeth and a firm handshake. But his intervention on behalf of Hatton is heartless, and wholly at odds with his gleaming image. They called him the Golden Boy with good reason. He won Olympic gold at Barcelona, flashed a blinding smile across his handsome face and went on to conquer boxing, millions of female hearts and all suspicions that boxers leave their brains in the ring when they retire. No fighter generated more money from the business – $696m in pay-per-view revenue alone, and $70m of that outlandish total arrived in his last bout.
It was a farewell performance that should inform De la Hoya's care for his fighters, because it was in the same ring against the same man who so devastatingly ended Hatton's career five months later. No doubt De la Hoya wanted fans to remember his world title triumphs at six weights, his great nights against great fighters, such as Julio César Chávez, Pernell Whitaker, Héctor Camacho, Ike Quartey and Arturo Gatti, even his losses to Shane Mosley but possibly not his one to Bernard Hopkins.
Yet it is the final memory that lingers, the tarnished Golden Boy slumped on his stool, unwilling and unable to continue what was a futile exercise from the moment he entered the ring, at 35, against a fighter who has a legitimate claim to be regarded as one of the best of all time.
Hatton, likewise, would prefer if we forgot his fight with Pacquiao. He spends every day trying to do so himself, but it is the unavoidable price he has to pay for his participation in a sport that asks more questions about the spirit than any other, and lays bare even minor shortcomings. Hatton's preferred dream is of the night six years ago when he thrilled his fans in Manchester by beating Kostya Tszyu, sending that wonderful champion into retirement.
Boxing demands sacrifices of muscle and heart that define champions and expose fraudsters. Hatton was never a fraud. He was, and remains, as brave as any man who stepped into a ring. But he has no need of friends who are prepared to send him back to the playground of lies.
Parker or Bale it's Modric for me
Scott Parker has carried West Ham United all winter. But has he had a bigger season than Gareth Bale has had for Tottenham at the other end of the Premier League? There can't be much in it.
A constituent majority of 350 of my wise friends in the Football Writers' Association (quite a few of whom are Hammers fans) disagreed with the game's players and voted Parker their player of the year.
I suspect, though, that Parker's fire-and-thunder half-time speech that inspired West Ham to come back from 3-0 down and draw with West Bromwich Albion in February significantly informed their choice. His team-mate Carlton Cole said at the time: "It was inspirational. If you were in there, you'd have a tear in your eye." Writers love stuff like that.
It is also a perversity of this job that we tend to go against the grain. I'm doing it now. In this instance, though, the FWA ignored the evidence of Bale's breathtaking performances for Spurs in Europe and probably regarded his flickering influence at home as a negative. Eight of 24 former winners, incidentally, went for Bale.
As it happens, I think the writers and players were both wrong; for me, Tottenham's Luka Modric, a magical playmaker built in the image of Ossie Ardíles, was better than Bale, and just ahead of Nemanja Vidic, who demonstrated again that he is surely one of the great centre-halves. But, as Kurt Vonnegut almost said, what do any of us know about a hill of beans?


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The C. elegans model system is ideal for studying the genetic and molecular mechanisms of the control of cell division and differentiation in vivo. We focus on the epidermal "seam cells" that undergo a stereotyped pattern of divisions throughout larval development, followed by terminal differentiation at adulthood. Seam cells exhibit stem-cell- like behavior, including self-renewal through either asymmetric or symmetric cell division. The execution of symmetric and asymmetric cell divisions by seam cells is regulated by developmental timing mechanisms that have been extensively characterized in our lab. In the first Aim of the project, we will explore how developmental timing regulators interface with pathways affecting cell division polarity to control when seam cells switch from asymmetric to symmetric cell division.
The second Aim will extend these studies to identify new genes that affect the regulation of symmetric vs. asymmetic cell divisions in seam cells.
The third Aim will utilize C. elegans as a model to study the mechanisms governing stem cell quiescence. Mammalian adult stem cells commonly transition between proliferative and quiescent states, depending on extracellular signals. During quiescence, a stem cell's vitality and developmental potential is maintained for extended periods of time. We propose to learn about mechanisms that controlling stem cell maintenance during quiescence in dauer larva developmental arrest. The dauer larva is an optional developmentally-arrested second stage larva that is induced in response to environmental conditions unfavorable for growth. In dauer larvae, the seam cells enter quiescence, and remarkably, this quiescence profoundly affects how seam cells respond to certain developmental regulatory genes, including the evolutionarily conserved lin-4 and let-7 microRNA genes. Studying how developmental quiescence interacts with developmental timing regulators in C. elegans cell lineages should reveal fundamental principles of stem cell behavior relevant to human biology, including development, cancer, tissue homeostasis and wound healing.
C. elegans is an excellent system for the genetic analysis of developmental processes in animals, including the control of cell division, cell number, and cellular differentiation. Since many of the proteins and other regulatory molecules that control C. elegans development are also found in mammals, understanding their roles in C. elegans should reveal the mechanisms and principles underlying developmental processes common to all animals, including humans.
|McJunkin, Katherine; Ambros, Victor (2014) The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans. G3 (Bethesda) 4:1747-54
|Nelson, Charles; Ambros, Victor; Baehrecke, Eric H (2014) miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. Mol Cell 56:376-88
|Zinovyeva, Anna Y; Bouasker, Samir; Simard, Martin J et al. (2014) Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression. PLoS Genet 10:e1004286
|Zou, Yan; Chiu, Hui; Zinovyeva, Anna et al. (2013) Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science 340:372-6
|McManus, David D; Ambros, Victor (2011) Circulating MicroRNAs in cardiovascular disease. Circulation 124:1908-10
|Ambros, Victor (2011) MicroRNAs and developmental timing. Curr Opin Genet Dev 21:511-7
|Karp, Xantha; Ambros, Victor (2011) The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans. Genetics 187:345-53
|Hammell, Christopher M; Lubin, Isabella; Boag, Peter R et al. (2009) nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Cell 136:926-38
|Zhang, Liang; Hammell, Molly; Kudlow, Brian A et al. (2009) Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development 136:3043-55
|Hong, Xin; Hammell, Molly; Ambros, Victor et al. (2009) Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci U S A 106:15085-90
Showing the most recent 10 out of 40 publications

subset: commoncrawl


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Season 2 of the Overtime podcast is here! Listen to the first episode with Meg Robichaud now.
This is a follow-up to the previous shot.
So, some people have told me "What if I don't have space to put a proper language menu with full text? Can I use flags then to save space?"
Well, the answer would still be "no".
In case of a reduced space, it's better to use a 2 letter language code, as defined by ISO 639.
Please! do not confuse ISO 639, for languages, with ISO 3166, for countries (which is the one used for Top Level Domain Names).
The correct ISO code for Japanese is "ja", not "jp". Same with Chinese, the correct ISO code is "zh", not "cn".
Chinese and Japanese, as well as Korean, are very particular languages, as the characters used to name those languages takes really little space, so you could still use the full name of the languages ("中文" - Zhongwen, or written Chinese language, "日本語" - Nihongo for Japanese, and "한국어" - Hangugeo, the name given to Korean language in South Korea).
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Lot 813: MOSER COBALT BLUE & GILT GLASS VASE
November 6 Estate Auction
by Butterscotch Auction Gallery LLC
November 6, 2016
Bedford Village, NY, USALive Auction
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Description: early 20th Century, with blue rectangular reserves and dendritic gilt highlights, h. 10-1/2 in.
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Functional Magnetic Resonance Imaging (fMRI) has become a method of choice for human functional neuroimaging studies, and is beginning to make inroads into clinical applications such as monitoring of stroke rehabilitation. However, in current practice, fMRI suffers from the uncertain relation of the imaged hemodynamic responses to the underlying neuroglial activity and quantitative hemodynamic parameters. Interpretation of fMRI studies in disease states are even more ambiguous since it requires not only understanding the mechanisms of neurovascular coupling but the impact of altered cerebrovascular dynamics on the BOLD signal under conditions of neurovascular deficit. As a result, the analysis of fMRI data has so far been largely correlational and descriptive. In order to gain a mechanistic understanding of the relationship between BOLD contrast and the underlying neuroglial activity, one has to consider multiple physiological processes, from macroscopic hemodynamic changes to the microscopic neurovascular communication. To this end, we will combine direct and quantitative measurement of hemodynamic and neuronal parameters simultaneously with fMRI aiming to understand the relationship between the BOLD response and the underlying neuroglial activity. We then will establish microscopic correlates of large-scale (populational) hemodynamic and neuroglial signals and will integrate macro- and microscopic measurements. Specifically, in Aim1 we will characterize BOLD signals in hemodynamic terms by employing simultaneous optical imaging of blood oxygenation and blood flow.
In Aim2 we will establish a correlation between stimulus-induced BOLD response and the underlying neuronal and astrocytic activity by performing simultaneous calcium imaging (using fluorescent calcium indicators) and voltage-sensitive dyes imaging. Our choice of calcium as an indicator of neuroglial activity is based on its recognized role as an important second messenger in multiple molecular signal transduction pathways, including those intimately involved in neurovascular communication. Finally, we will establish microscopic correlates of the large-scale hemodynamic and calcium signals by using 2-photon microscopy (Aim 3). Integration of macroscopic fMRI and calcium measurements with 2-photon data will allow a mechanistic interpretation of BOLD signals in terms of activity of underlying single cells and single blood vessels. 1
The relationship between functional MRI (fMRI) signals and the underlying microscopic neurovascular unit (NVU) physiology is a central unresolved issue in the interpretation of human functional neuroimaging data. The main goal of this proposal is to combine quantitative optical measurements of hemodynamic and neuroglial signals directly with BOLD fMRI aiming for a mechanistic interpretation of BOLD signals in terms of activity of the underlying single cells and single blood vessels. The proposed project will provide a mechanistic framework for understanding of fMRI signals and ultimately will guide the development of novel therapeutic, preventative, and diagnostic approaches. 1
|Sridhar, Vishnu B; Tian, Peifang; Dale, Anders M et al. (2014) Neurovascular Network Explorer 1.0: a database of 2-photon single-vessel diameter measurements with MATLAB(®) graphical user interface. Front Neuroinform 8:56
|Gratiy, Sergey L; Pettersen, Klas H; Einevoll, Gaute T et al. (2013) Pitfalls in the interpretation of multielectrode data: on the infeasibility of the neuronal current-source monopoles. J Neurophysiol 109:1681-2
|Nizar, Krystal; Uhlirova, Hana; Tian, Peifang et al. (2013) In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci 33:8411-22
|Devor, Anna; Sakadzic, Sava; Srinivasan, Vivek J et al. (2012) Frontiers in optical imaging of cerebral blood flow and metabolism. J Cereb Blood Flow Metab 32:1259-76
|Devor, Anna; Sakadzic, Sava; Saisan, Payam A et al. (2011) "Overshoot" of O? is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci 31:13676-81
|Tian, Peifang; Devor, Anna; Sakadzic, Sava et al. (2011) Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain. J Biomed Opt 16:016006
|Tian, Peifang; Teng, Ivan C; May, Larry D et al. (2010) Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proc Natl Acad Sci U S A 107:15246-51


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Why You Need To Change Your Opinion Of MSC Dining Options
September 23, 2016
Everyone loves a bit of cruise ship food. In fact, guests love it so much that for every week they cruise on average they'll gain at least a pound!
Many passengers travel with their stomachs' leading the way so with that in mind, we decided to find out exactly what the food is like on an MSC cruise.
Does the Mediterranean cuisine impress? Are the speciality options as good you'd hope? And what else can you feast upon on-board an MSC cruise? Well, read on to find out!
Main Dining Rooms
The main dining rooms on MSC don't just serve up Italian! They offer a wide range of quality dishes that showcase both Mediterranean and international cuisine. Enjoy tastes of every nationality on-board and a range of dishes that change every day as well as the always available favourites.
It's up to you how many courses you choose to indulge in but there will be the choice of a starter, salad, pasta, main and dessert at the very least! Examples of what you can eat include lobster bisque, prawn cocktail, fire roasted tomato soup, Dijon and herb crusted rack of lamb and molten chocolate cake.
Tex Mex
This speciality restaurant takes you into a world of Mexican food. Sip on strong and sharp strawberry margaritas whilst you work your way through a menu of enchiladas, fajitas, quesadillas and nachos. You can also sink your teeth into prime cuts of Angus beef and Italian Fiorentina steak. Just take a look at some of the spicy offerings below!
Galaxy Restaurant/ Kaito Sushi Bar
Several MSC ships feature the Galaxy restaurant which serves up a gastro journey through international cuisine as well as Japanese food. Dine on fresh seafood such as oysters and fusion dishes to set your taste buds alight.
In the evenings Galaxy restaurant also has a great ambience as it has stunning views, sparkling light fittings and an edgy fifties feel. There's also a range of Galactic cocktails to try as well as traditional Japanese drinks such as plum wine and sake.
Kaito Sushi Bar serves up sushi, sashimi and tempura with Japanese flavoured teas and extensive speciality treats. Whether you prefer to stick to your Italian or taste food from another part of the world, you won't be disappointed on MSC!
Yacht Club Dinner
The Yacht Club is exclusive to guests staying in its suites and the restaurant here is certainly something special! You'll be able to fine any time and enjoy food that is expertly prepared in a very relaxed, intimate setting. The menu includes an extensive wine list with expert sommelier, fresh dishes such as risotto, braised lamb shank, a selection of fine cheese and delicious desserts. You'll be spoilt rotten!
Our specialist cruise consultant Lee told us about his experience of Yacht Club food: "I chose 5 courses on this occasion finishing with the Italian Classic Tiramisu. One of the best I have had in fact every dish was delicious." You can hear more from Lee about his time on-board MSC here!
Eataly Restaurant
Step into Eataly and learn all about the finest Italian foods. Take a bite of pizza made with traditional sourdough and premium toppings, tuck into cold cuts of meat and tasty cheeses or enjoy traditional Italian pasta. There is also an Eataly Steakhouse which, as you'd assume, serves up tremendous steak! Our advice? Make sure you're hungry before you head there!
Ristorante Italia
As you can probably guess, this restaurant showcases traditional Italian food! It serves an a la carte menu which is made with traditional culinary techniques and ingredients with many slow cooked foods and great wine pairings. Morsels include mini lasagne au gratin and for dessert, why not try chocolate mouse cake with hazelnut cream filling and crushed meringue?
The Buffet
There are 13 different stations to browse in the buffet as you choose your lunch and eat as much or as little as you like! Want to enjoy everything from pasta to curry, to carvery to salad all in one sitting? Feel free! You'll be able to watch the chefs assemble the dishes in front of you whilst you tuck into bread, healthy options, pizza, desserts and much more.
Each section of the buffet is clearly labelled so you always know what you're choosing, and there'll also be a clear set of allergen advice so you'll know you've chosen something that's safe for you to eat. The buffet is also open for an impressive 20 hours a day so you can always catch a bite when hungry.
You can take a look a look around the buffet on the MSC Preziosa here!
Room Service
The room service menu on MSC is available for you to be able to eat whatever time you get hungry! Enjoy a selection of sandwiches, wraps, salads, fruit platters and even pizza. In fact, MSC boast to have the best pizza at sea, so why not try it and find out?
Different food options are available on different ships, so check which ones are included on your ship if there's one you'd particularly like to try! Want to find out more about MSC Cruises? Read our introduction to MSC here, find out surprising facts you never knew about MSC here or read the eight reasons why everyone should be cruising with MSC here!
So what do you think of the food on MSC cruises? Have you sailed with them before? What is your favourite restaurant on-board? Let us know in the comments below…
Other Articles you may be interested in
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Wordpress Site for GSLogics123
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Main Office
The Department's mission is to research, teach and apply knowledge related to movement, exercise and human occupation with the ultimate goal of enhancing human health, productivity, and quality of life. Regular physical activity reduces the risk of developing or dying from some of the leading causes of illness and death in the United States, so the study of movement, exercise and occupation has the potential to dramatically impact health and quality of life.
Feel free to contact us if you have any questions.
UW-Madison's Lisa Cadmus-Bertram recently appeared on Wisconsin Public Radio's "The Larry Meiller Show" to talk about a research project she is leading that is examining how to motivate cancer patients to become more physically active. READ THE RECAP or LISTEN TO THE SHOW to learn more about this amazing research being done in the UW Madison Kinesiology Department!
Countless amazing Occupational Therapists have made their difference in the world by helping those in need in the 100 years that Occupational Therapy has been around, however, we have the honor of being affiliated with Dr. Hasselkus, who has been names one of Occupational Therapy's 100 most influential people in the last 100 years! LEARN MORE about this amazing and dedicated Professor and the work she has done to make her mark in the world of Occupational Therapy and those who benefit from it!
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