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Dementia is a collective term used to describe various symptoms of cognitive decline, such as forgetfulness. It is a symptom of several underlying diseases and brain disorders.
This article discusses the potential causes of dementia, the various types, and any available treatments.
Contents of this article:
Fast facts on dementia
Here are some key points about dementia. More detail and supporting information is in the main article.
- There are an estimated 47.5 million dementia sufferers worldwide
- One new case of dementia is diagnosed every 4 seconds
- Dementia mostly affects older people, but is not a normal part of aging
What is dementia?
Dementia is not a normal part of aging.
Dementia is not a single disease in itself, but a general term to describe symptoms such as impairments to memory, communication, and thinking.
While the likelihood of having dementia increases with age, it is not a normal part of aging.
Light cognitive impairments, such as poorer short-term memory, can happen as a normal part of aging. This is known as age-related cognitive decline rather than dementia because it does not cause significant problems.
Dementia describes two or more types of symptom that are severe enough to affect daily activities.
An analysis of the most recent census estimates that 4.7 million people aged 65 years or older in the United States were living with Alzheimer's disease in 2010. The Alzheimer's Association estimates that:
- Just over a tenth of people aged 65 years or more have Alzheimer's disease
- This proportion rises to about a third of people aged 85 and older
- Alzheimer's accounts for 60-80 percent of all cases of dementia
Causes of dementia
Dementias can be caused by brain cell death, and neurodegenerative disease - progressive brain cell death that happens over time - is behind most dementias.
But, as well as progressive brain cell death, like that seen in Alzheimer's disease, dementia can be caused by a head injury, a stroke, or a brain tumor, among other causes.
- Vascular dementia - resulting from brain cell death caused by conditions such as cerebrovascular disease, for example, stroke. This prevents normal blood flow, depriving brain cells of oxygen.
- Injury - post-traumatic dementia is directly related to brain cell death caused by injury.
Some types of traumatic brain injury - particularly if repetitive, such as those received by sports players - have been linked to certain dementias appearing later in life. Evidence is weak, however, that a single brain injury raises the likelihood of having a degenerative dementia such as Alzheimer's disease.
Dementia can also be caused by:
- Prion diseases - for instance, CJD (Creutzfeldt-Jakob disease)
- HIV infection - how the virus damages brain cells is not certain
- Reversible factors - some dementias can be treated by reversing the effects of underlying causes, including medication interactions, depression, vitamin deficiencies, and thyroid abnormalities
Types of dementia
Alzheimer's is characterized by "plaques" between the dying cells in the brain and "tangles" within the cells (both are due to protein abnormalities).
The brain tissue in a person with Alzheimer's has progressively fewer nerve cells and connections, and the total brain size shrinks.
Dementia with Lewy bodies is a neurodegenerative condition linked to abnormal structures in the brain. The brain changes involve a protein called alpha-synuclein.
Mixed dementia refers to a diagnosis of two or three types occurring together. For instance, a person may show both Alzheimer's disease and vascular dementia at the same time.
Parkinson's disease is also marked by the presence of Lewy bodies. Although Parkinson's is often considered a disorder of movement, people with Parkinson's can also go on to develop dementia symptoms.
Huntington's disease is characterized by specific types of uncontrolled movements but also includes dementia.
Other disorders leading to symptoms of dementia include:
- Frontotemporal dementia (also known as Pick's disease)
- Normal pressure hydrocephalus (when excess cerebrospinal fluid accumulates in the brain)
- Posterior cortical atrophy (resembles changes seen in Alzheimer's disease, but in a different part of the brain)
- Down syndrome (increases the likelihood of young-onset Alzheimer's)
Symptoms of dementia
Dementia symptoms include memory loss, disorientation, and mood changes.
A person with dementia may show any of the problems listed below, mostly due to memory loss - some of which they may notice themselves, while others may only be picked up by caregivers or healthcare workers.
The signs used to compile this list are published by the American Academy of Family Physicians (AAFP) in the journal American Family Physician:
Possible symptoms of dementia:
- Recent memory loss - a sign of this might be asking the same question repeatedly
- Difficulty completing familiar tasks - for example, making a drink or cooking a meal
- Problems communicating - difficulty with language; forgetting simple words or using the wrong ones
- Disorientation - getting lost on a previously familiar street, for example
- Problems with abstract thinking - for instance, dealing with money
- Misplacing things
- Mood changes
- Personality changes - perhaps becoming irritable, suspicious or fearful
- Loss of initiative - showing less interest in starting something or going somewhere
Diagnosing dementia
The first step in testing memory performance and cognitive health involves standard questions and tasks.
Asking simple questions, such as "who is President?" will give doctors an indication of whether there is dementia or not and help to decide whether further investigation is needed.
Simple word knowledge tests and drawing tasks are included alongside memory questions.
Research has shown that dementia cannot be reliably diagnosed without using the standard tests below, completing them fully, and recording all the answers; however, diagnosis also takes account of other factors.
Cognitive dementia tests
Today's cognitive dementia tests are widely used and have been verified as a reliable way of indicating dementia. They have changed little since being established in the early 1970s.
The abbreviated mental test score has 10 questions which include:
- What is your age?
- What is the time, to the nearest hour?
- What is the year?
- What is your date of birth?
Each correct answer gets one point; scoring six points or fewer suggests cognitive impairment.
The General Practitioner Assessment of Cognition (GPCOG) test includes an added element for recording the observations of relatives and caregivers.
Designed for doctors, this sort of test may be the first formal assessment of a person's mental ability.
The second part of the test probes someone close to the patient and includes six questions to find out whether the patient has:
- Become less able to remember recent events or conversations
- Begun struggling to find the right words or using inappropriate ones
- Found difficulty managing money or medications
- Needed more help with transport (without the reason being, for example, injury)
If the test does suggest memory loss, standard investigations are then recommended, including routine blood tests and a CT brain scan.
Clinical tests will identify, or rule out, treatable causes of memory loss and help to narrow down potential causes, such as Alzheimer's disease.
The mini-mental state examination (MMSE) is a cognitive test which measures:
- Orientation to time and place
- Word recall
- Language abilities
- Attention and calculation
- Visuospatial skills
The MMSE is used to help diagnose dementia caused by Alzheimer's disease and also to rate its severity and whether drug treatment is needed.
Treatments for dementia
Brain cell death cannot be reversed, so there is no known cure for degenerative dementia. Management of disorders such as Alzheimer's disease is instead focused on providing care and treating symptoms rather than their underlying cause.
If dementia symptoms are due to a reversible, non-degenerative cause, however, treatment may be possible to prevent or halt further brain tissue damage. Examples include injury, medication effects, and vitamin deficiency.
Symptoms of Alzheimer's disease can be reduced by some medications. There are four drugs, called cholinesterase inhibitors, approved for use in the U.S.:
- Donepezil (brand name Aricept)
- Alantamine (Reminyl)
- Rivastigmine (Exelon)
- Tacrine (Cognex)
A different kind of drug, memantine (Namenda), an NMDA receptor antagonist, may also be used, alone or in combination with a cholinesterase inhibitor.
Cholinesterase inhibitors can also help with the behavioral elements of Parkinson's disease.
Other quality-of-life care
"Brain training" can help improve cognitive functioning and help deal with forgetfulness in the early stages of Alzheimer's. This might involve the use of mnemonics and other memory aids such as computerized recall devices.
Prevention of dementia
Certain risk factors are known to be associated with dementia. However, age is the biggest predictor. Other risk factors include:
- Smoking and alcohol use
- Atherosclerosis (cardiovascular disease causing the arteries to narrow)
- High levels of "bad" cholesterol (low-density lipoprotein)
- Above-average blood levels of homocysteine (a type of amino acid)
- Diabetes
- Mild cognitive impairment can sometimes, but not always, lead to dementia


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Few of the tributes that cascaded in yesterday for Michael Jackson made reference to the performer's highly publicised troubles in recent years. The sad truth, though, is that it was these troubles, much more than Jackson's extraordinary talent, that had come to define his public persona over the past two decades.
There was the extreme plastic surgery, the erratic behaviour, the failed relationships, the health issues, the financial problems and, most damaging of all, the accusations of child abuse. Many of those who had once admired Jackson were repelled by the tawdry freak show that his life had become.
All but his most hardcore fans recognised that the creative muse had deserted Jackson some time ago. It was clear that the series of 50 shows in London that he was due to play this summer was inspired not by a genuine urge by the performer to return to the stage but from an urgent need to repay his creditors.
Some are even suggesting that the physical stress of preparing for these shows might have brought on the heart attack that killed him. None of this tragedy of wasted talent and physical decline was reflected in the warm words from fellow performers and other celebrities yesterday.
And yet it would be unfair to identify something dishonest or hypocritical in these tributes. What they reflect – and what the outpourings of sadness from huge numbers of people around the world show – is an appreciation for the extraordinary contribution Jackson made during his long career as a performer and artist.
Jackson's legacy will not be the freak show, but the music he made at the height of his powers. And what will remain in people's minds, long after memories of his sad fall have vanished, is how thrilling he was as a performer in his effervescent pomp.
Jackson touched the lives of hundreds of millions of people across the planet with his talent. His music reached across national borders and between generations. And, as the singer's album shot up the charts of the online retailer Amazon yesterday, it was, ultimately, to the music to which people returned upon the sad news of his premature death.
- More about:
- Amazon (Company)
- Electronics
- Loans And Lending Market
- Singers

subset: commoncrawl


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To compound this problem, merchants can alienate their existing customers by offering coupons.
It may be that for some Groupon merchants, even a 75 percent discounted sale is thus profitable.
So the merchants offer a deal, sometimes at a loss, but then get little future business.
How are merchants supposed to defend against this sort of mass attack?
Professors, merchants, and journalists each have their special day, while Brazilians of color have two.
The merchants accepted the invitation, and went home with Eirik.
On the face of it, they would have been a match for ten times this number of merchants.
It was built by some English merchants, and is called Calcutta.
The Tasmanian merchants met them on the shore of the royal province.
Hitherto the stock employed in banking was supplied by the merchants, or invested by East Indian capitalists.
c.1200, from Anglo-French marchaunt "merchant, shopkeeper" (Old French marcheant, Modern French marchand), from Vulgar Latin *mercatantem (nominative *mercatans) "a buyer," present participle of *mercatare, frequentative of Latin mercari "to trade, traffic, deal in" (see market). Meaning "fellow, chap" is from 1540s; with a specific qualifier, and suggesting someone who deals in it (e.g. speed merchant "one who enjoys fast driving"), from 1914.
c.1400, from merchant (n.) and from Old French marcheant (adj.).
combining word
A person who esp indulges or purveys in what is indicated: heat merchant/ speed merchant (1914+)
The Hebrew word so rendered is from a root meaning "to travel about," "to migrate," and hence "a traveller." In the East, in ancient times, merchants travelled about with their merchandise from place to place (Gen. 37:25; Job 6:18), and carried on their trade mainly by bartering (Gen. 37:28; 39:1). After the Hebrews became settled in Palestine they began to engage in commercial pursuits, which gradually expanded (49:13; Deut. 33:18; Judg. 5:17), till in the time of Solomon they are found in the chief marts of the world (1 Kings 9:26; 10:11, 26, 28; 22:48; 2 Chr. 1:16; 9:10, 21). After Solomon's time their trade with foreign nations began to decline. After the Exile it again expanded into wider foreign relations, because now the Jews were scattered in many lands.


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Taiwan is sending three of its best films to be screened at the Berlin Film Festival in February. It is hoping that its participation in the festival will help the international film community recognize the talent of young Taiwanese filmmakers.
Taipei comic festival attracts more than 300,000 people
Taiwan's Changhua County going green
Lunar New Year warning: Watch the calories


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622 views as of March 2, 2011
Our Raffle Challenge in $$☻Get Art Promoted☺$$Top 10 in Ponds, Rivers, Streams, Lakes, and Oceans in The Male Photographer
Also won second place in Arlington (TX) Camera's 2009 Photo Contest in the landscape category
clouds landscape reflection hdr arkansas hwy 7 terence russell
Beautiful! I love Arkansas… lived there many years ago. I am guessing this was taken in the northwest part of the state?
Actually Delany, this was taken pretty far south. We turned off the Interestate in Hope to catch 7 and this was found soon after we turned to go toward Hot Springs.
I'm live in Arkansas and it is beautiful along Hwy 7….I used to visit Hot Springs Nat'l park every summer….loved it the further you go the more beautiful it gets…wonderful piece of work here Love the treatment.
Thanks. We had a blast! Saw Petit Jean, Devil's Den, and Queen Wilhelmina State Parks as well as Hot Springs. The only thing that hampered the trip was the low clouds and rain we encountered in Petit Jean.
Yet another wonderful shot!
Jake, this was my first "best" HDR composition. ;) I still count it among the best.
great shot, I traveled north on 7 from Russellville and its beautiful up that way too
Thank you, Ted. We got as far as Russellville, as I had to go see a town with my family name, but had to head back toward home by that time. I have been to Branson a couple of times, though, and have traveled the backroads through NW Arkansas a few times. It is gorgeous in the Ozarks.
Ted, we travelled 7 from the Missouri border to I-30 on our way home over Columbus Day weekend. It was a very pleasant drive until it got dark about the time we made Russellville.
I live very close to this area, about 40 minutes or so from Hope, and you captured the beauty that I sometimes take for granted. Nice work!
Thanks, Dan. It is strange how we miss that which is right around us but see things in other places that the locals never notice.
beautiful scenery! the reflections are incredible!!
I thought the colors, reflections, and sky all came together in this shot. It is one of my favorites.
It is a peaceful scenic Terence, beautiful work.
Thank you, Sharon. As I have told others, this is one of my favorites among my collection.
how beautiful this is, Terence … somehow it gives me the feeling of the world at the dawn of time … there's such a quiet newness about it!!!!! Wonderful capture!!!
It never surprises me any more how you always give me a way to look at my own images! Thanks!!!!!!!
Beautiful work.
Thanks, Ken. I was pleased to find last week that I had came in second in a great local photo contest with this one!
It is a very beautiful image Terence, I love the dramatic skies and wonderful DOF. It is a beautiful wilderness.
Thank you, Sharon. I am always amazed at the difference in the ways I see things now than I did before I got seriously into photography. I seldom pass a water crossing without slowing somewhat to see whether it is photoworthy!
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When Brazilian-born chef Marcello started his career at 14, he may not have anticipated working on the starkly beautiful island of Skye – but then he probably didn't expect to be crafting some of the most exquisitely refined Scottish-influenced food on the planet, either.
After college, Marcello caught the attention of Albert Roux, who took him under his wing at Home Roux – the first UK restaurant to feature sous vide techniques. After six years under Roux – at Le Gavroche, Rouxl Britannia and La Boucherie Lamartine – Tully moved into the catering industry.
After several years in catering, the reigning monarch of Scottish home cookery, Lady Claire Macdonald, chose him to head the kitchen at Kinloch Lodge. The restaurant has since won three AA rosettes and a Michelin star.
Dan Saltzstein of the New York Times calls Tully's cooking 'restrained' and 'luscious', while the Sunday Times' Allan Brown remarked that 'every mouthful was heaven'.
When Living Scotsman asked Marcello what his most useful kitchen utensils are, Marcello cheekily replied, 'My palate and my pots.' Judging by the mouth-watering food that emerges from Kinloch Lodge's kitchen, both are in peak condition.
Making extensive use of the venison, game birds (like wild pigeon) and the ultra-fresh fish so plentiful on Skye, Marcello's food is unquestionably Scottish. Yet it is influenced by modern European preparations that Marcello perfected during his time with Albert Roux, and accented by the occasional off-shore ingredient (often citrus).
Douglas Blyde of Harpers points out, "…savoury use of fruit depicts his Brazilian heritage while generous, concentrated sauces reveal the influence of French training."


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We have changed tactics a bit and have a tag for this release (rather than pushing trunk). Tag is at
Instructions for upgrade are at
Pending release takes precedence (unless this has to happen because of the release).
Changing the subject to reflect the whiteboard.
Lowering priority so it doesn't page.
We have a problem - see bug 556679 and bug 556690.
I deleted the tag (r1921), will retag once this problem is solved.
I heard this is Thursday with follow-on work this weekend.
New tag coming shortly.
Tagged at
All done with the code and cron jobs. Will hang on to this bug until the weekend push is complete.
All done.


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The Counsellor (Michael Fassbender/Brad Pitt) Character Poster Gallery
The Counsellor film tells the story of a lawyer (Michael Fassbender), who finds himself in over his head when he gets involved in drug trafficking. Directed by Ridley Scott, the film also stars Penélope Cruz, Cameron Diaz, Javier Bardem and Brad Pitt.. View character posters…
Roll your mouse over the left and right-hand sides of the image and then click to view more pictures.
5 of 5
Watch the trailer for The Counsellor
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In the spiritual documentary Wake Up, Jonas Elrod has the ability to see spirits—even while sitting with Oprah in the radio studio! Find out what Jonas saw, what color Oprah's aura is and how Jonas knows she's a good person. More on Jonas and "Super Soul Sunday"
Wake Up was directed by Jonas Elrod and Chloe Crespi and produced by Steve Hutensky. Learn more at WakeUptheFilm.com


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UAB study identifies pathway that may cause seizures and shorten survival for patients with severe brain tumors
- Researchers at the University of Alabama at Birmingham have identified a chemical pathway that may be associated with seizures and shorter patient survival in some patients with malignant glioma, the most common and deadly form of brain tumor. In findings published May 27 in Science Translational Medicine, the researchers suggest that a transporter known as SXC is responsible for boosting levels of glutamate in the brains of some glioma patients.
System xc-(SXC) expression in human glioma cells growing in vitro. The catalytic subunitof SXC, SLC7A11/xCT (green) is highly expressed in approximately half of gliomas. The cell structure (red) and nuclei (blue) show the morphology of these glioma cells. Confocal image by Stephanie Robert and Ian Kimbrough.Glutamate is a vital neurotransmitter in the brain; but increased expression of glutamate can kill healthy cells surrounding a malignant tumor, giving the tumor more room for growth. Glioma-produced glutamate may also be responsible for seizures that are present in about half of all glioma patients.
"We hypothesized that the SXC glutamate transporter, and in particular a sub-unit called SLC7A11, was responsible for this increase in glutamate," said Harald Sontheimer, Ph.D., professor in the Department of Neurobiology and senior author of the study. "In both animal models and in human glioma cells, we found that approximately 50 percent of patient tumors had elevated SLC7A11 expression, and those tumors grew faster, killed more healthy cells, induced seizures and shortened overall survival than did tumors lacking this transporter."
Human astrocytes expressing glial fibrillary acidic protein (GFAP, blue) and their nuclei (orange) in the brain of a patient suffering from seizures. Confocal image by Stephanie Robert and Ian Kimbrough. Analysis of human glioma tissue showed that 54 percent of glioma patients had elevated tumor SLC7A11 expression, whereas the remaining 46 percent had lower expression, comparable to controls. Gliomas with elevated SLC7A11 corresponded well with the incidence of tumor-associated seizures reported in the glioma patient population. The findings also showed that lack of SLC7A11 expression conferred an improved clinical outcome for patients, who lived nine months longer on average.
"These findings suggest that SXC is the major pathway for glutamate release from gliomas and that SLC7A11 expression predicts accelerated growth and seizures," said Stephanie M. Robert, a graduate trainee in the M.D/Ph.D. program in Sontheimer's laboratory and first author of the paper.
The team had previously discovered that an FDA-approved drug for ulcerative colitis and inflammatory bowel disease called sulfasalazine can inhibit glutamate release via SLC7A11. The researchers then conducted a clinical pilot trial with nine glioma patients. Using magnetic resonance spectroscopy, glutamate levels were measured before and after patients took an oral dose of sulfasalazine.
Spectral image of human glioma cells expressing enhanced green fluorescent protein (EGFP, green) growing intracranially in a mouse. Confocal image by Ian Kimbrough."In the nine glioma patients with biopsy-confirmed expression of SXC, we found that the presence of SXC positively correlates with glutamate release, which is acutely inhibited with oral sulfasalazine," said Sontheimer, who is also the director of the UAB Center for Glial Biology in Medicine.
While the study findings suggest that reducing glutamate levels in patients with elevated expression of SXC would be beneficial in controlling seizures and slowing tumor growth, sulfasalazine is an imperfect drug for that role.
"Sulfasalazine is approved as an oral medication, and most of each dose is absorbed in the gut. Perhaps as little as 20 percent makes it to the brain," Sontheimer said. "It also has a very short biological half-life and quickly loses its effectiveness. More specific SXC inhibitors with improved specificity and bioavailability are under development and may soon enter clinical trials."
Also of potential clinical relevance is the finding that magnetic resonance spectroscopy may serve as a tool to determine whether a patient has elevated tumor SLC7A11 expression.
Human glioma cells (green) expressing enhanced green fluorescent protein (EGFP) migrating away from the tumor mass (bottom left of image) along the vasculature of the brain.Image acquired in a live mouse using two-photon microscopy. In vivo two-photon image by Ian Kimbrough. "Future studies will be needed to examine whether SXC-mediated glutamate release measured by magnetic resonance spectroscopy may serve as a sensitive, noninvasive clinical marker to identify those patients who will experience more rapid disease progression and seizure complications," Robert said. "This screening could also help identify patients who may benefit from therapies that target SXC inhibition."
The wide-ranging study benefited from diverse UAB expertise in several fields. UAB's neuro-oncology program, led by co-author Louis B. Nabors, M.D., professor in the Department of Neurology, was instrumental in conducting the clinical studies. Co-author Adrienne C. Lahti, M.D., professor in the Department of Psychiatry and Behavioral Neurobiology, brought expertise in magnetic resonance imaging from studies she is doing examining the association of glutamate with anti-psychotic drugs.
Other co-authors are:Susan C. Buckingham, Ph.D., Susan L. Campbell, Ph.D., Stefanie Robel, Ph.D., Kenneth T. Holt, Toyin Ogunrinu-Babarinde, UAB Center for Glial Biology in Medicine; Paula Province Warren, UAB Division of Neuro-oncology; David M. White, Meredith A. Reid, Ph.D., UAB Department of Psychiatry and Behavioral Neurobiology; and Jenny M. Eschbacher, M.D., and Michael E. Berens, Ph.D., Cancer and Cell Biology Division, the Translational Genomics Research Institute, Phoenix, Ariz.
By: Bob Shephard
UAB Media Relations
UAB chosen for 2016 Edmond J. Safra Fellowship in Movement Disorders
The University of Alabama at Birmingham has been chosen by the Michael J. Fox Foundation for Parkinson's Research as one of five academic centers to host the inaugural class of the Edmond J. Safra Fellowship in Movement Disorders.
By increasing resources for specialized training for clinician-researcher neurologists, the program — made possible by The Edmond J. Safra Foundation — aims to grow the global base of movement disorder specialists treating people with Parkinson's and contributing to research toward breakthrough treatments for the disease.
"There is a growing need for neurologists with additional training in movement disorders," said David G. Standaert, M.D., Ph.D., professor and chair of the Department of Neurology. "We are honored to have been selected by The Michael J. Fox Foundation to grow the number of clinician-researchers equipped to provide optimal care to Parkinson's patients and conduct the urgent work to learn more about this disease and to develop new therapies."
UAB is now recruiting a neurology resident for the 2016-2018 Edmond J. Safra Fellowship in Movement Disorders class.
A committee of advisers selected by MJFF named the five centers. The others are Columbia University Medical Center in New York; Emory University in Atlanta; Northwestern University in Chicago; and Toronto Western Hospital in Ontario, Canada
"People with Parkinson's disease are the true beneficiaries of this program," said Mrs. Lily Safra, chair of the Edmond J. Safra Foundation. "These prestigious institutions are equipped to offer fellows the training and experience that will help them better serve their Parkinson's patients."
- BY: Bob Shepard/UAB Media Relations
UAB opens the third clinic in the world for patients with transverse myelitis
UAB Media Relation
UAB has established the third multidisciplinary comprehensive clinic in the world for transverse myelitis, a rare spinal cord disease.
Physical therapist Melissa Daniel works with Mike Jezdimir, a transverse myelitis patient at UAB.Mike Jezdimir knows firsthand how hard it is to get appropriate medical treatment for his condition, a disease of the spinal cord called transverse myelitis. He has had it for 48 years, since he was 17. TM is fairly uncommon, and many physicians rarely encounter it. Treatment options are limited.
There were only two comprehensive clinics in the world for TM until the University of Alabama at Birmingham recently opened the third multidisciplinary, comprehensive clinic for transverse myelitis at UAB's Spain Rehabilitation Center.
Jezdimir is a patient at UAB and the creator of the Mike L. Jezdimir Transverse Myelitis Foundation, raising money for UAB TM research. Amie (Jackson) McLain, M.D., the chair of the UAB Department of Physical Medicine and Rehabilitation, directed him to Tara DeSilva, Ph.D., a scientist in the department who studies multiple sclerosis, a disease similar to TM.
Jezdimir sparked her research interest in transverse myelitis and connected her with the Transverse Myelitis Association, where conversations about the necessary components for a designated transverse myelitis clinic at UAB began.
"This is a game changer for those of us with transverse myelitis and for UAB," Jezdimir said.
The clinic joins two others — at Johns Hopkins University and the University of Texas Southwestern — as the only comprehensive clinics for treating TM. It will combine physicians and other medical professionals from multiple disciplines, including physical medicine and rehabilitation, neurology, neurosurgery, urology, and pain management, in caring for patients with TM, which can cause loss of motor function or paralysis.
"The mission of our multidisciplinary clinic is to provide the best care possible to patients living with transverse myelitis," said William Meador, M.D., assistant professor in the Department of Neurology. "We also combine excellent clinical care with research efforts to better understand and treat this illness."
The clinic offers immediate access to a number of rehabilitation specialists, such as physical, occupational and speech therapists, orthotic specialists, and many others. The clinic also serves as an educational tool to expose medical students and residents to transverse myelitis in a constructive and meaningful manner.
|In the United States, up to 10,000 people will develop TM annually. Although it can affect people of all ages, it typically strikes people in their teens and early 20s, or in their 30s and 40s. About half of all TM patients experience significant recovery, but the other half have profound loss of motor skills or experience some level of paralysis.
"Those patients require a multifaceted approach, and the comprehensive nature of our clinic creates a synergy among the diverse branches of medicine involved, leading to outstanding medical care," McLain said. "The UAB TM clinic provides one-stop shopping, so each patient can see all the medical professionals who have a role in their care at one time and in one place. For patients with mobility issues, this is a tremendous benefit."
"We are blessed in Alabama to have an academic medical center such as UAB with the expertise and knowledge to provide the depth of care needed by patients with TM," Jezdimir said. "This is only the third clinic of its kind in the world, and the combination of outstanding patient care with UAB's robust research efforts gives me hope that new therapies, or even a cure, can someday be found."
UAB's transverse myelitis research efforts are spearheaded by DeSilva along with Chander Raman, Ph.D., a professor in the Division of Clinical Immunology and Rheumatology, and Hui Hu, Ph.D., associate professor in the Department of Microbiology.
Their collaboration seeks to understand how inflammation can damage or destroy myelin, the fatty insulating substance that covers nerve cell fibers.
"This damage causes nervous system scars that interrupt communications between the nerves in the spinal cord and the rest of the body," DeSilva said. "We will employ advanced imaging techniques and novel approaches in epigenetic research on immune cells to further our understanding of transverse myelitis. This information will help facilitate our pre-clinical studies in animal models to develop future clinical therapies."
The most common causes of TM are inflammation, infection and stroke, although in many cases the cause is never determined. Symptoms can vary greatly depending on which portions of the spinal cord are affected. The most common symptoms include numbness in the extremities, weakness of the legs or arms, loss of bladder and bowel control, inability to walk, and impaired balance.
The transverse myelitis clinic is held the third Thursday of each month at the Spain Rehabilitation Center, 1717 Sixth Ave. South. Appointments can be made at 205-934-4179.
BrightFocus Foundation grant to fund new UAB and Southern Research Alzheimer's research
By Bob Shepard
UAB Media Relations
Research to identify a new approach to treat Alzheimer's disease gets new funding after a pilot grant from the Alabama Drug Discovery Alliance.
Researchers at the University of Alabama at Birmingham and Southern Research are launching a new study to identify a novel therapy for treating Alzheimer's disease. Funded by a grant of $250,000 from the BrightFocus Foundation, the new study grew from preliminary work funded by the Alabama Drug Discovery Alliance.
Principal investigator Erik Roberson, M.D., Ph.D., associate professor in the Department of Neurology and co-director of the Center for Neurodegeneration and Experimental Therapeutics at UAB, and co-principal investigator Corinne E. Augelli-Szafran, Ph.D., director of the chemistry department at Southern Research, will lead this program focusing on targeting the interaction between tau and fyn, two proteins in the brain that are involved with Alzheimer's disease.
"We've long known that the protein tau is associated with Alzheimer's disease," said Roberson. "Fyn is a protein involved in learning and memory, and has more recently been implicated in neurological conditions such as Alzheimer's and epilepsy. There are now considerable data suggesting that blocking the interaction between tau and fyn could be protective against Alzheimer's."
Roberson says previous research has shown that lowering tau in the brain in animal models seems to prevent Alzheimer's disease, and the tau/fyn linkage is an intriguing target for blocking tau's function without having to reduce tau levels, which may be difficult in human patients.
"The interaction seems to be key," Roberson said. "But we can test this only by finding drugs that block that interaction. The BrightFocus Foundation grant, following on the heels of our ADDA funding, will fund the next step in this process."
|The UAB School of Medicine and Southern Research began the Alabama Drug Discovery Alliance in 2008, with crucial contributions from the UAB Center for Clinical and Translational Science and the UAB Comprehensive Cancer Center. The ADDA's objective is to use the resources available at these institutions to facilitate drug discovery and development.
"This is an excellent example of taking groundbreaking basic research to the next level, and it demonstrates the unique capabilities within the ADDA," said Mark J. Suto, Ph.D., vice president of drug discovery at Southern Research.
The first phase of this work, funded by the ADDA, used the state-of-the-art high-throughput screening facility at Southern Research to look for compounds that acted upon the interaction of tau and fyn. More than 100,000 compounds were screened, from which about 30 compounds showed a positive response. The new grant from BrightFocus will allow the research team to further evaluate the active compounds with the goal of identifying the top two or three candidates for a potential drug that could interfere with the tau/fyn connection.
Those candidates will then be tested in animal models of Alzheimer's disease with the ultimate goal of entering into human clinical trials for the treatment for the disease.
"This is an exciting and novel therapeutic approach for the treatment of Alzheimer's disease," Augelli-Szafran said. "Having been able to identify potential chemical matter from our high-throughput facility at Southern Research gives us an edge moving forward with this research program. With our drug discovery talent here at Southern Research and our research and clinical expertise at UAB, we anticipate that this program will have an impact on the Alzheimer's disease community."
The researchers will employ the BrightFocus Foundation grant to help support the necessary work to find the strongest contenders for a new potential drug candidate — work that got its start with the ADDA.
"This grant illustrates how we are leveraging institutional investments by both UAB and Southern Research to attract outside investment in our programs," said Maaike Everts, Ph.D., director of the ADDA and an associate professor in the Department of Pediatrics. "I think the funding of this proposal illustrates the quality of the science and the approach we have here in the Alabama Drug Discovery Alliance, and how the strengths of both institutions complement each other, making for a very attractive partnership for external investment."
BrightFocus Foundation is a nonprofit organization supporting research and providing public education to help eradicate brain and eye diseases, including Alzheimer's disease, macular degeneration and glaucoma.


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Publication Name: New Braunfels Herald Zeitung
Location: New Braunfels, Texas
Pages Available: 250,382
Years Available: 1952 - 2013Learn More About This Publication
New Braunfels Herald Zeitung (Newspaper) - January 11, 2003, New Braunfels, Texas Page 2A— HERALD-ZEITUNG — Saturday, January ll, 2003 Worid Briefly Powell: North Korea 'thumbs nose' at world WASHINGTON (AP) — The United States Friday condemned North Korea's decision to quit a treaty considered the cornerstone of global efforts to curb the spread of nuclear weapons. "North Korea has thumbed its nose at the international community," said Secretary of State Colin Powell, speaking alongside Mohamed ElBaradei, director general of the International Atomic Energy Agency. Ultimately, Powell said, the U.N. Security Council must take up North Korea's pursuit of nuclear weapons and shirking of international obligations. At the same time, Powell renewed the Bush administration's overture to hold direct talks with North Korea. ElBaradei also took a hard line, accusing North Korea of "a policy of defiance." He said unless North Korea reversed its actions within a few weeks the Security Council should intervene. December ends 2002 with jobless rate at 8-year high WASHINGTON (AP) — U.S. com-panies slashed 101,000 jobs in December as retailers limped through a cheerless holiday season, leaving unemployment at an eight-year high of 6 percent at the close of a year that many workers want to forget. Last month's job cuts, the sharpest in IO months, were widespread and followed a revised loss of 88,000 in November, the Labor Department said Friday. The data offered a snapshot of a sputtering economy that is hemorrhaging jobs, increasing the political urgency for President Bush as he promotes his $674 billion economic stimulus plan. Friday's report capped a gloomy year for jobseekers, who saw the unemployment rate rise from 5.6 percent last January to end the year at 6 percent. Hamas urges Iraq to form suicide squads to fight West JABALIYA REFUGEE CAMP, Gaza Strip (AP) — The militant group Hamas, which has carried out scores of suicide bombings in Israel, urged Iraq on Friday to copy its tactics and send thousands of attackers with explosives strapped to their bodies into a battle against the West. "We call on the Arabs and Muslims to bum the land under the feet of the American invaders, especially our brothers in Saudi Arabia because this war is not against Iraq, it's against the Islamic nation," Hamas leader Abdel Aziz Rantisi told a rally in this impoverished shanty encampment. Hamas has dispatched most of the 92 suicide bombers that have killed hundreds of Israelis in more than two years of Israel-Palestinian fighting. Rantisi's remarks were unusual for Hamas, which has focused on fighting Israel since taking up arms in 1987 at the start of the Palestinian uprising. Texas Lotto SATURDAY $15 million 09-10-13-27-39-48 WEDNESDAY $20 million 01-10*18-23-44-49 Contact Us HERALD-ZEITUNG 707 Landa St., New Braunfels, TX 78130 (830) 625-9144, fax (830) 625-1224 www.herald-zeitung.com Doug Toney, Editor and Publisher Ext. 201, [email protected] Gary E. Maitland, Managing Editor Ext. 220, [email protected] Heather Grant, Business Manager Ext. 202, [email protected] Lisa Schreler, Composing Manager Ext. 205, [email protected] Henry Coello, Commercial Prmtin^lnformation Systems 625-5232, [email protected] Arnold Wiggins, Production Manager (830) 625-5232, [email protected] David Gehret, Circulation Manager Ext. 228, [email protected] Courtney Abernathy, Advertising Manager Ext. 208, [email protected] For classified advertising, call 625-9144 ext. 215 For display advertising, call 625-9144 ext. 208. For obituaries, wedding, engagement and anniversary announcements, call 625-9144 ext. 213. For missed or late newspapers, call 625-9144 ext. 229.Today Contact Features Editor Brian Grant, 625-9144 ext. 222 Community Events ► Birthdays/Anniversaries Happy Birthday to Lynn Thompson and Roland Leos Jr. (10 years, Jan. 9). To have a birthday or anniversary listed here, call 625-9144. ►Schools COMAL ISD ■ Area choir auditions ■ SVHS boys soccer at SAISD tournament NEW BRAUNFELS ISD ■ NBHS choir at SAISD area auditions, Reagan High School ■ Area E band auditions ■ NBHS boys soccer at SAISD tournament ►Live Music GRUENE HALL, 1281 Gruene Road, 606-1281 Today — The Weary Boys, 1 to 5 p.m., no cover Today — Two Tons of Steel, 8 p.m., $10 SAENGERHALLE, 255 Saengerhalle Road; 625-HALL (4255) Today — Ray Wylie Hubbard, 9 p.m., $10 CHEATHAM STREET WAREHOUSE, 119 Cheatham, San Marcos; (512) 353-3777 Today — Karen Posten UPTOWN PIANO BAR, 295 E. San Antonio, 620-7600 Saturdays — Tammy and Steve Palmer RILEY'S TAVERN, 8894 FM 1102, Hunter, Texas 78132; (512) 392-3132 Today — RiverTrain, 9 p.m. ROLLIN ON THE RIVER, An Oldies Saloon and Grill, FM 306 and 2673, Canyon Lake; (830) 907-3535 Saturdays — Deejay dance music and karaoke DAM RED BARN, 16520 S. Access Dam Road; Canyon Lake; (830) 964-4045 Saturdays — Live Music Photo submitted Bill Brown Elementary fourth-grader Martha Laura McCracken shares a book with Principal Jo Beth Jimerson. Martha wrote, illustrated and published a book as part of a $4,500 "Project Publish" grant funded by the Comal Public School Foundation. Book titles ranged from "The Fairy" to "The Black Devil." Sports was a popular topic among the boys too with a book called "Touchdown!" and another one simply called "Sports." Another student called his book "The Ghost with White Eyes" and "Crazy Chicken Pox" was a hit as well. ►Clubs and Events GUADALUPE VALLEY AMERI-CAN LEGION POST 35 conducts smoke-free Bingo every Saturday afternoon at the Post Home, 4210 FM 482 (Old Solms Road). Early Bird begins at 1:30 p.m. and regular bingo at 2 p.m. For information call 625-5535. NARCOTICS ANONYMOUS meets at 6:45 p.m. and noon every day except Saturday at the 24-hour club at 1142 Eikel. HONEY CREEK MORNING GUIDED TOURS take place at 9 a.m. Saturdays. Meet at the Rust House inside the park, wear com fortable shoes and dress for the weather. For information call (210) 520-6412 or (830) 438-2656. A FREE KIDNEY DISEASE CONFIDENTIAL HEALTH SCREENING has been scheduled from 10 a.m. to 2 p.m. today at One Lexington Medical Building, Renal Associates, 215 E. Quincy, Suite 610 in San Antonio. Appointments are recommended, call 829-1299. THE AMERICAN SEWING GUILD, San Antonio Chapter, is sponsoring Resolutions 2003, at 9 a.m. today at the Schertz United Methodist Church, 3460 Roy Richard Drive. Embellishments is the theme, and kits will be provided for hands-on activities. Cost is $50 and includes a soup and salad lunch. Call (210) 337-4365 for information. ►Heads up THE GERMAN-AMERICAN SOCIETY sponsors German classes from 6:30 to 7:45 p.m. Thursdays for children ages 8-12, beginning adults and intermediate. Classes start Jan. 23. For information, call 620-6787 or 660-0437. THE NEW BRAUNFELS REPUBLICAN WOMEN annual membership dinner features the Rev. Buckner Fanning as guest speaker. Officers will be installed. The event begins at 6 p.m. Jan. 27 at the New Braunfels Civic Center, 380 S. Seguin Ave. Tickets are $15 for the dinner and speaker, or $5 to just hear the speaker. For reservations, call 629-1760. THE MCKENNA CLUB offers square dancing lessons from 3 to 5 p.m. Fridays today through March 28. Cost for members is $24 per person or $45 per couple. Cost for non-members is $48 and $90 per couple. For information, call 629-5627. AARP DRIVER SAFETY program evening classes are offered to drivers 50 years and older who want to refresh or improve their defensive driving skills and quality for a multiple-year auto insurance discount. Classes take place from 6 to 10 p.m. Jan. 14 and 15 at Peace Lutheran Church, 1147 S. Walnut Ave. Cost is $10. Contact Bob Karabinus at (830) 620-0675 for information. THE ELKS HOOP SHOOT, a national free-throw contest for boys and girls ages 8-13, takes place from 2 to 6 p.m. today at the New Braunfels Presbyterian Church, 373 Howard St. Awards will be presented for the top three in each age group. THE GREATER NEW BRAUNFELS CHAMBER OF COMMERCE sponsors a Lunch and Learn seminar from 11:30 a.m. to 1:30 p.m. Jan. 16 at Honors Hall. Topic is "Business Alternatives for Developing Alliances." For seminar fee and registration, call 625-2385 or log onto www.nbcham.org. Seating is limited. THE GREATER NEW BRAUNFELS ARTS COUNCIL ' will conduct its annual Dinner with the Arts Jan. 19. The theme is "You Gotta Have Art." Tickets * are available at China-n-Things and the chamber of commerce. THE NEW BRAUNFELS LIONS CLUB hosts the Big Band 5 Dance featuring Joe Rogers and his 15-piece orchestra to benefit the NB Noon Lions scholarship programs from 7 to 10 p.m., Friday, Jan. 17 at the Civic Center. ^ Tickets are $12.50, available at Johnson Furniture Store on Seguin Street. Call 625-5321. Weather Digest Saturday, Jan. 11 ACCUWeather.com forecast for daytime conditions, high/low temperatures ►Today's forecast KAN. Amarillo 43°/24° OK LA NM Midland 5Su/33 Wichita Falls 45 /28 • Dallas 44 30 El Paso 64°/37" I 1 j I • • [Austin »r/35 San Antonio 49'738* MEXICO © 2003 AccuWeather, Inc. Brownsville 57°/5r } ___y^\ ar ^ TODAY TONIGHT Mostly cloudy Cloudy Highs lower 50s Lows lower 40s Rain: 20 percent Rain: 30 percent E wind, 10 mph SE wind, 10 mph O mm eve •*** *£h*> it t ■. i. ■ '' " ' J - v * v Sunny Pt Cloudy Cloudy Showers T-storms Rain Flumes Snow Ice Via Associated Press Arrests Law enforcement officers in Comal County charged the fellowing Jan. 9 and 10: Devin A. Devie, 20, Kieen, driving while license suspended. Melissa A. Flores, 26, expired driver's license, (alure to maintain financial responsibility (2 counts), violation of promise to appear, expired license plates, speeding — 44 mph in a 30 mph zone. Archie Gilbert, 24, New Braunfels, probation vwialxxVdrMng while intoxicated, burglary of a ►Extended outlook Sunday —- Mostly cloudy with a 30 percent chance of showers. Highs in the mid 50s. Lows in the upper 30s. Monday — Partly cloudy. Lows in the upper 30s to tower 40s. Highs in the upper 60s. Tuesday — Partly cloudy with a slight chance of showers. Lows in the mid to upper 40s. Highs in the tower 60s. Wednesday — Partly cloudy with a chance of showers. Lows in the tower to mid 40s. Highs in the tower 60s. Thursday — Partly cloudy with a chance of showers. Lows in tthe mid 30s. Highs in the tower 50s. building. Robert M. Hyde, 33, New Braunfels, failure to maintain financial responsibility. John M. Jonas, 23, Canzo Springs, failure to appear/possession of marijuana. Javier Leal, 20, New Braunfels, possession of less than 2 ounces of marijuana. Donald R. Mitchell, 33, Canyon Lake, driving white license suspended. Harold E. Mortag, 65, San Antonio, driving while intoxicated Darren K. Nnneman, 39, Spring Branch, failure to appear/dnvng while intoxicated, open alcohol container Maria I. Penatoza, 38, New Braunfels, assault causing body injury to family member. Daniel Prentice, 17, Canyon Lake, disorderly conduct (fighting). Johnny Rodriguez, 22, New Braunfels, theft by check between $20 and $500. Ismail Valero, 42, New Braunfels, probation vioiafiorVassault ►Water flows Edwards Aquifer 693.7 ft. Comal River 444 cfs Canyon Dam inflow 575 cfs Canyon Dam outflow 300 cfs Canyon Dam lake level 909.2 ft. above mean sea level NBU Pumping Report Surface water , 6.429 million gallons Well water 0.346 million gallons ► Polen counts Molds........................... low Mountain Cedar very high (Provided courtesy of Dr. Frank Hampel) ►Sunrise/Sunset Sunrise......................7:29 a.m, Sunset........................5:53 p.rrv Construction- ■ Walnut Avenue will be closed in both directions at the Interstate 35 overpass from 10 p.m. to 6 a.m. Jan. 16 while workers pour concrete on the northbound Interstate 35 main lane bridge deck. Traffic will be detoured to FM 725 or Schmidt/Spur Street. ;


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- Houston, TX
- Full-time
Company Description
Proserv is a production technology and services company for the energy industry. We have the know-how to maximize recovery, minimize costs and enhance sustainability. Our experts devise ingeniously simple and reliable solutions that deliver every time.
With dynamic brands such as: Gilmore Valves, Argus Subsea, Hydrafit Subsea, Proserv Offshore and Proserv Technology, together, we offer a truly international service for projects of any scale. Quite simply, this alignment enables Proserv to give clients even higher standards of quality, service and reliability.
Job Description
Work with engineers and Designers to produce parts, assemblies and drawings of oilfield subsea equipment. The right candidate for this position will be motivated, innovative, resourceful, well organized with excellent inter-personal skills.
Designs, plans and oversees the specification, development, installation, operation and maintenance of equipment and/or machinery. This professional will also conduct research to solve practical engineering problems and improve efficiency.
Key Accountabilities (includes, but not limited to the following)
- Create complete product layouts, working detail drawings, subassemblies and final assemblies including various views, sections & details.
- Drawings show complete dimensional data for engineering or manufacturing purposes.
- Research, plan, coordinate and proposes original designs of mechanical products and systems.
- Perform original design and layout work to develop new or modified products in CAD.
- Employ extensive knowledge of engineering theory, mathematics and practical mechanics to solve design and production problems.
- Consult with appropriate engineers during the engineering and design phase to ensure that assembly best practices are considered.
- Identify potential obstacles and establish corrective measures prior to release.
- Provide technical assistance on the shop floor when required.
- Lead continuous improvement efforts for assembly to optimize resources, processes and procedures.
- Analyzes product or equipment specifications and performance requirements to determine designs which can be produced by existing manufacturing or processing facilities and methods.
- Provides technical information concerning manufacturing or processing techniques, materials, properties, and process advantages and limitations which affect long range product engineering planning.
- Confers with personnel and customers to clarify or resolve problems, and develops design.
- Directs and coordinates manufacturing or building of prototype product or system.
- Confers with other engineering personnel and prepares design modifications as required.
- Must have 2+ years experience with SolidWorks and a firm understand of parametric modeling practices
- AutoCAD experience a plus
- Strong mechanical aptitude a plus
- Ability to create and manage bill of materials
- MS Word, MS Excel experience
- API 6A knowledge a plus
- GD & T a plus
- Effective written and verbal communication skills
- Must be able to work on multiple projects at any given time
- Ability to follow up on tasks
- Must have a strong attention to detail and ability to work accurately
Additional Information
Please direct any questions to firstname.lastname@example.com


text:
Tagged As
News Roundtable | PDX Women's March | Astoria Play
OPB | Jan. 20, 2017
In a 1 p.m. show following NPR special coverage, we'll talk about the inauguration and other news of the week, look ahead to the Women's March on Portland, and hear about a play about Astoria.
Race In The Northwest | Jordan Refugee Camp | Oregon's Non-unanimous Juries
OPB | Dec. 21, 2016
We explore OPB's series on racial identity, talk with a former lawmaker about his first-hand experience visiting a refugee camp in Jordan, and hear a number of perspectives on the wisdom of allowing non-unanimous jury verdicts.
News Roundtable | Post-Election Bullying In Schools | Orange Line
OPB | Nov. 18, 2016
Our news roundtable analyzes some of the week's big news. We hear about how Oregon schools are addressing post-election bullying and racism. And we discover how well a new light rail line in the Portland area is — or is not — easing congestion.
Writer Sherman Alexie: Thunder Boy Jr.
OPB | Nov. 17, 2016
Northwest writer Sherman Alexie talks about his new children's book, "Thunder Boy Jr."
Single Working Mother Says The American Dream Is For The Community
OPB | Oct. 13, 2016
Ana del Rocío Valderrama says she has a good job but she still struggles mightily, and the dream is not complete until the most vulnerable in the community are taken care of.
Talking Business | Grant High Students Go To Washington | All About Lichen
OPB | Oct. 11, 2016
This hour on TOL: An update of regional business news; a conversation with the four Portland teens whose film was featured at the White House Student Film Festival; and lichen and why it matters.
Portland Police 48 Hour Rule Agreement | Millennials In Parks | Republicans Talk Trump
OPB | Sept. 15, 2016
We chat with millennials enjoying the outdoors and Republicans weighing their response to Trump. Also, Portland's mayor joins us for a conversation about what a new police union contract could do for the city.
People Of Color In The Cannabis Industry | Eugene's Racist History | Comic City, USA
OPB | Aug. 23, 2016
We discuss the challenges facing people of color who want to get involved in business opportunities in the pot industry. A University of Washington professor fills us in on Eugene's racist past. And we'll hear about the new comics exhibit at the Oregon Historical Society.
News Roundtable | Ban The Box | Marijuana Research
OPB | Aug. 12, 2016
The weekly news roundtable addresses the presidential race, Portland's potential new homeless shelter and public records reform in Oregon. Also, a UO researcher explains "ban the box," and an Oregon cannabis researcher reacts to the DEA's announcement.
An Oregon Republican Millennial On His Experience At The RNC
OPB | July 20, 2016
Portlander Xander Almeida attended the Republican National Convention in Cleveland and shared his perspective with Think Out Loud producer Julie Sabatier.
Former Speaker Of Oregon House Celebrates 85th Birthday As Delegate
OPB | July 18, 2016
Larry Campbell served as the speaker of Oregon's House of Representatives from 1991-1995. Now he has come to Cleveland as a Kasich delegate, though he was originally a Ben Carson supporter.
Blueberries Are Big | PPS Civil Rights Complaint | RNC Preview
OPB | July 11, 2016
The Oregon blueberry harvest this year may be record-breaking. Also, a Portland Public School Board member has accused the district of bias, and we preview the Republican National Convention starting next week.
OPB's Election Night Special: Wins For Kate Brown, Bud Pierce, Ted Wheeler, Bernie Sanders
OPB | May 17, 2016
We talk to reporters at rallies across the state, nominees—some with victory speeches and some with concession speeches—and outright winners in Oregon's 2016 primary.
The Occupation Effect | Endorsement Roundtable | Voter Vox
OPB | May 16, 2016
We check in on how Harney County elections are being affected by the armed occupation there earlier this year. Then we talk with regional newspaper editors who defend their endorsements in Oregon's May 17 primary election. We round out the hour by hearing directly from voters about who they're voting for.
Sanders Addresses Malheur Occupation, Gun Control, His Path Forward
OPB | May 06, 2016
Presidential candidate Bernie Sanders spoke with Think Out Loud's Dave Miller about the Malheur occupation, gun control, and what the race looks like going forward.
Jim Wallis And 'America's Original Sin'
OPB | Feb. 22, 2016
We talk to progressive Christian leader Jim Wallis with an audience at First Christian Church in downtown Portland about his new book, "America's Original Sin: Racism, White Privilege and the Bridge to a New America."
News Roundtable: Dec. 18, 2015
OPB | Dec. 18, 2015
We review some of the biggest news stories of the week.
Dante James On The City Of Portland's Equity Priorities
OPB | Dec. 17, 2015
We talk to the director of Portland's Office of Equity and Human Rights about what he's accomplished in the last four years and his hopes for the future.
Portland State Students Want To Do More For Minorities On Campus
OPB | Dec. 10, 2015
PSU students are bringing a list of demands to the next board of trustees meeting.
Lewis & Clark Looks Into Alleged Hate Crime On Campus
OPB | Nov. 23, 2015
A black student reported he was attacked by three men early Saturday morning.


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Kouign Amann, Set of 8
- Exclusive
- Online Only
- Summary
To pastry chef Jean-Yves Charon, a kouign amann tastes like home. From his native Brittany, this classic Breton "butter cake" relies on layers of handmade puff pastry dough to create a decadent treat with a sweet, buttery center and crisp caramelized-sugar coating. Hand made with the finest natural ingredients, the frozen pastries are simple to prepare—just let them rise overnight and bake. They emerge from the oven with crunchy, sugar-speckled exteriors, tender interiors and an irresistible buttery aroma.
- 8 pastries; 2 lb. 3 oz. total.
- Shipped frozen.
- Made in USA.
- A Williams Sonoma exclusive.
- Use & Care
Receiving Instructions
- The kouign amann was shipped frozen with dry ice, which may have evaporated during shipment. This is normal. Please take care not to touch any remaining dry ice with bare hands. Upon receipt, immediately place the kouign amann in the freezer, where it will keep up to one month frozen.
- Lightly spray the inside of each mold with nonstick cooking spray and place a kouign amann in each mold. Place the molds on a baking sheet and cover with a piece of parchment paper. Let the kouign amann rise in their molds at room temperature for 8 to 10 hours.
- Preheat an oven to 350ºF.
- Remove the parchment paper. Transfer the baking sheet to the oven and bake the kouign amann in the molds until slightly puffed and golden brown on top, 30 to 35 minutes. Let cool for 5 to 10 minutes before serving. Makes 8 kouign amann.
- Ingredients
- Enriched flour (wheat flour, niacin, iron, thiamin mononitrate, riboflavin, folic acid, enzyme, ascorbic acid [dough conditioner]), butter, sugar, water, yeast, salt, dough conditioner blend (wheat flour, malted barley flour, ascorbic acid [dough conditioner], enzymes).
- Shipping
Shipping Information
Please allow up to two weeks for processing and delivery of perishable items, which are shipped two-day delivery to ensure freshness. Perishable items are not eligible for rush shipping.
Shipping Rates
The shipping rate varies depending on your order total and shipping destination. View Shipping Options and Charges.
Return Policy
At Williams-Sonoma, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction are our priority. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement.
We cannot accept returns on monogrammed, personalized, special-order items, custom upholstery, food, items shipped direct from the vendor, or on items damaged through normal wear and tear. Final sale items ending in .97 or .99 cannot be returned. View Full Return Policy.
Rated 1 out of 5 by Beverleyy from Not fresh, didn't rise, bad product I have ordered these in the past and they were delicious - not this year. I placed an order in late November and when I took them out of the freezer, they looked freezer-burned. They didn't rise at all and were hard disks when they came out of the oven. I thought maybe UPS had allowed them to thaw on the truck (the dry ice was intact, though) so I I placed another order. The second order was worse! Bad product!Date published: 2017-01-09Rated 1 out of 5 by annepp from Did not rise We've been ordering Williams and Sonoma pastries for years now and have always loved them. I followed the directions, exactly as it was written, and rested it for 10 hours. These pastries did not rise at all, and were just as flat after 10 hours of "rising." They didn't change at all after I baked them. Don't know if it was a bad batch. Huge disappointment, and definitely not worth the price.Date published: 2016-12-06Rated 2 out of 5 by miken from not worth the enormous price They barely rose; basically like a cinamon cookie or donut from the supermarketDate published: 2016-11-20Rated 5 out of 5 by DnSF from You have to get 2 boxes! Seriously, the aroma wafts thru the air and people show up at your door. Follow the prep instructions provided for best results, I go for maximum bake time for crustiest exterior. I've found them locally but to get to those places takes time I prefer using elsewhere, having these in the freezer are handy, and if I might suggest "bribe" worthy, if I have to explain you don't know how. Prepare a pot of coffee or steep tea as this bakes, everyone invited will appreciate it, even the inquisitive ones who show up asking, "what smells so good?" You can eat leftovers the next day but why make so much, when you can make it fresh the next morning?Date published: 2016-08-27Rated 5 out of 5 by PTCMiMi from A delicious treat! These delectable pastries are hard to find, but worth the search. They arrived in good shape and were delightfully buttery and flaky with just a hint to sweetness.Date published: 2016-04-29Rated 1 out of 5 by bfromca from a frozen easter I sent this as a gift but without instructions on the outside of the package, the little pastries were unbaked on Easter morning. Apparently, they needed to not only be defrosted but they needed to rise for 8-10 hours. Simple instructions on the OUTSIDE of the box would have been more than just helpful. B in CADate published: 2016-04-11Rated 4 out of 5 by Euskaldun from Delish...but These are absolutely delicious. However, it would be nice if the package indicated that it should be laid flat in the freezer. In order to save space in the freezer I had this (and a LOT of other stuff) sideways in order to pack the freezer during the holidays. I didn't realize that there was a not-completely-frozen topping on these and it oozed out of the box a bit. Of course, that didn't keep us from enjoying them tremendously!!Date published: 2016-01-13Rated 5 out of 5 by SandyCandy from Sinfully decadent treat! I saw these on a television food show several years ago, and was always curious about them. I decided to give them a try, and it was love at first bite. They remind me of my favorite buttery and flaky croissant. Although a tad sweeter, they make for a wonderful breakfast with coffee. I especially love the buttery crunchy bottom. I highly recommend this yummy pastry.Date published: 2015-09-15


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- Author: Unknown author
- Format:Paperback
- Publisher:Guardian Books
- Published:28 June 2012
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Product description
- Total Pages: 368
- Genre: Cycling
- Illustrations: Illustrations
Having started in 1903 as a publicity stunt for an ailing French newspaper, the Tour de France is now the world's greatest sporting spectacle. Back then, cyclists raced alone through the night, sometimes at the risk of being beaten up. Today's riders pedal 3,500 km around the French countryside, cheered on by huge roadside crowds and accompanied by the mighty caravan of media, sponsors and support staff that keeps the wheels turning. But one thing hasn't changed: the Tour remains just as awe-inspiring a test of extreme mental and physical stamina as it has always been. The Tour de France. to the Bitter End is the best of over a century of Guardian and Observer Tour reporting, with pieces from Christopher Brasher, Michael Davie, Geoffrey Nicholson, William Fotheringham, Richard Williams, Phil Liggett and many other writers seduced by the power of the peloton.


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Carson-Dellosa Publishing Division Facts 0-12 Flash Cards w/Round Corners, 6 x 3, 93 Two-Sided Cards/packMath Flash Cards
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Carson-Dellosa Publishing Division Facts 0-12 Flash Cards w/Round Corners, 6 x 3, 93 Two-Sided Cards/pack - An indispensable educational tool to help students study and memorize. Sturdy two-sided cards feature rounded corners for easy sorting. Includes one resource card.
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hey guys !
this is a concept i thought up while playing with a full auto RBG i made. i'm not gonna be posting the RBG full-auto, cause my friend that built it with me begged me not to (he's kinda greedy and wanted it all to himself). i'm not gonna be posting instructions for this either, but i am going to show you the gun and explain how it works. it's really simple - if you have even a little bit of experience with knex you should be able to build it off the pics and the video.
ROF : about up to 6 per second (depends on the speed you crank the crank)
range : 3-4 feet
comfortability : very comfortable
accuracy : cannot be checked at this point, because the range isn't high enough
mag capacity : 18 (variable)
looks : pretty good
sturdiness/stability : very sturdy/stable
reliability : pretty reliable, jams every 10 mags or so, but can be easily fixed.
anyway, this gun isn't made for performance. as oblivitus has done several times, i have introduced this brand new concept to the knexing community, in hope that people will take it to the next level, because i think, and i believe oblivitus would agree with me, that this gun concept has a lot of potential, and can get up to 30 feet. sadly, this gun does not have a trigger, but there is a crank that you control the gun with. don't leave comments saying "it's lame", "it's weak", "it doesn't have a trigger"... i know all these things. this is only a concept and a prototype with which i tested the concept. i hope this concept will be perfected and, hopefully, get a decent range. if it will, this will be the first firing pin machine gun ever to be built of knex !!! (not including multi barrel and multi ram guns, which, quite frankly don't find any sympathy in me).
i have a great idea how to make it much MUCH stronger. i made only 1 lame attempt at it and quit. what i'm talking about is adding a modification of kinetic's semi automatic mechanism. the one with the pusher that pushes the bullet against a mech that only slightly revolves allowing the bullet to pop out, but since it has a lot of band pressure, it propels the bullets really powerfully. you could add some kind of mod of that in front of the mag and in line with the ram (and bullet, of course), that when the ram goes forward, it pushes the bullet into the mech, which intern, pushes the bullet out of the gun with power. i was thinking of the pusher that pushes the bullets up in the semi-auto gun to be halfway up the barrel, with it's round side facing the bullet, so that when the bullet gets to it, it pushes the pusher (irony) down, and then the pusher pushes the bullet back up into pressure with the firing mechanism of the full-auto.
i sincerely hope i am understood, because this idea is amazing and would make this gun all that much better, cause if you would be able to make a strong, full-auto gun that uses a magazine, and doesn't need any cocking before use and is very simple to use, you would really be getting far.
best of luck to anyone who attempts to perfect this gun, and if anyone does, give me at least 10 percent credit for the idea please.


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- Author: Ian Whybrow
- Format:Paperback
- Publisher:HarperCollins Publishers
- Published:03 July 2006
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Product description
- Total Pages: 32
- Genre: Picture books
- Illustrations: 32 col illus
Shiver me timbers! A swashbuckling picture book adventure from the author of the phenomenally successful Harry and the Bucketful of Dinosaurs. It's story time at school, when all of a sudden...SPLASH!...the classroom fills with water and Tim and Ted find themselves taking part in a swashbuckling nautical adventure. Can they rescue stolen treasure from the pirates before Tim's mum comes to collect him at home time?
Author's Biography
Ian Whybrow is best known for his original humour and he always writes with adult readers as well as children in mind. He lives in Harrow-on-the-Hill and teaches at the John Lyon School. His wife Ann is also a teacher and they have two daughters, one of whom is Lucy Whybrow, the actress.


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Create recipes in your posts with a clean interface and layout that are easy to organize.
See our Documentation for more information.
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A: Yes! Use the template tag
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get_terms(). Note: This only supports a list output, not a cloud.
A: Yes! Use the template tag
recipress_recent($num , $image).
$num should be set to the number of posts you want to output and is set to 5 if ommitted.
$image should be set for displaying an image(1) thumbnail in the list or not(0) ans is set to 1 by default.
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Last Updated: 5 years ago
Active Installs: 1,000+
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Meanwhile, production in December will have fallen by more than 6 per cent and orders by more than 8 per cent compared with the same month last year, according to Confindustria, the Italian industrialists' association, setting a trend which is likely to continue during the year. Christmas shopping has confirmed this: Italians are buying fewer, and cheaper gifts and sales are down by 10 to 20 per cent or more.
One slight glimmer is that inflation is down from 4.9 per cent in November to 4.7 per cent, but largely to lure customers, and not a sign that industry is starting a necessary slimming cure. 'It is not linked to cuts in production and distribution costs,' remarked Ottaviano del Turco, deputy head of the left-wing CGIL trade union federation. 'The truth is that inflation is falling because people are beginning to buy less.'
The debts of Italian industry have ballooned as companies try to maintain a good level of investment while profits have shrunk, according to the year-end study by Mediobanca, the powerful investment bank, based on 180 key firms representing about one-third of the country's business.
And the Organisation for Economic Co-operation and Development (OECD) predicted this week that gross domestic product will increase only 0.8 per cent next year, about 30 per cent less than this year and half the growth forecast by the government. Production, it said, is likely to increase by only just over 1 per cent and the beginning of recovery cannot be expected until 1994.
Giuliano Amato, the Prime Minister, has pointed out that many of Italy's economic problems are the result of worldwide depression. But much also has to do with its own economic and structural crisis, caused by years of maladministration and the resulting colossal state deficit. At a traditional end-of-year news conference, Mr Amato said the problems of Italy's political system were more worrying than the country's crippled economy. 'Political corruption is an evil that must be uprooted. It can be like a floating mine that threatens to blow up the entire democratic system at any time,' he said.
Vittorio Merloni, a former president of Confindustria, said: 'It all goes back to the period between November 1989 and April 1992,' thus laying the blame, without naming him, on the former prime minister, Giulio Andreotti, for failing to bring about a much-needed restructuring of industry.
The OECD report said the government was on the right track with its austerity programme, but it warned that the Italian economy will have to go at a speed unprecedented in any industrialised country if it is to fulfil the obligations of the Maastricht treaty and remain in Europe. 'The stakes for Italy have never been so high since the end of the war,' it said.
- More about:
- Manufacturing
- Oecd
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iPhone apps
Heart Reaction
Welcome to Heart Reaction! It is a relaxation game in which you have to make a chain of heart. It starts with a challenge to complete two hearts. Onwards, the chain of heart to make in following rounds increases e.g. after two hearts you have to make….. Read more
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More than 50 doctors, nurses and medical technicians from as far away as Puerto Rico spent this week at the Center for Domestic Preparedness learning how to work in disasters.
On Friday, their training culminated with drill with the following scenario: A national singing competition in Anniston on Friday is struck by terrorists, resulting in injuries that quickly overwhelm a local hospital.
Large, military-looking tents set up outside the Noble Training Hospital at McClellan quickly filled with mock victims and the medical personnel treating them.
Those professionals are members of disaster medical assistance teams from across the country. The teams are part of a program of the National Disaster Medical System, which puts medical personnel on the ground after emergencies.
The system, which operated on a $52 million budget in 2013, is overseen by the U.S. Department of Health and Human Services. The Center for Domestic Preparedness partners with the department to hold these training sessions in Anniston, providing support, equipment and facilities.
Lou DeGilio, section chief for the National Disaster Medical System, said team members are taught how to do their jobs in the chaotic setting of a disaster, where resources are limited and the flow of incoming patients can be overwhelming.
The program works similar to the National Guard. Team members on deployment become active federal employees with all the benefits and pay during their disaster response work.
"Any area, regardless of their abilities to provide care, regardless of how robust their system is, can be overwhelmed," DeGilio said, speaking of the aftermath of a disaster.
In the hours after Hurricane Sandy, the many hospitals in the area were hit with the same waters and winds that battered residents along the East Coast, DeGilio explained.
"We can bring in our own stand-alone facilities," DeGilio said.
There are 86 teams across the country, 60 of which are Disaster Medical Assistance Teams like the ones training in Anniston Friday. Others are specialized to care for animals, mass fatalities, surgical needs and other specific areas of aid.
Keith Lindsay, a team commander from Massachusetts and a paramedic firefighter in his civilian job, sent five members of his team this week to provide medical care and aid to the many thousands of unaccompanied children crossing the southwestern border of the U.S.
On June 2, President Obama issued a memorandum addressing the influx of those children. The president requested a coordinated effort of multiple federal, state and local agencies to provide humanitarian aid.
As legislators continue to debate immigration, many emergency aid providers see the problem of thousands of children risking their lives to enter the country alone as a humanitarian issue.
"From our standpoint, we take the politics right out of it," said Dr. Andrew Garrett, director of the National Disaster Medical System. "We're public health and medical. There are politics in everything we do, but from the medical side, our teams are medical support and public health support."
Garrett, a pediatrician from Massachusetts, said the training sessions in Anniston were piloted near the end of 2013, and already, more than 500 team members from across the country have received training at the CDP.
A few team members Friday carried handheld computers used to relay medical information to superiors on the scene, and to administrators in Washington who use that information to determine the severity of the disaster and how best to respond.
"For Hurricane Sandy, we were able to have some good early intelligence," Garrett said.
Teams have responded to all sorts of natural disasters and emergency situations, and no two have identical needs, team members said Friday. Sometimes, what victims of a disaster require most is compassion.
Gary Kruschke, commander of a team in Florida, is a fire captain at Fort Walton Beach Fire Department when he isn't responding to disasters and terror attacks, such as the one that saw two airplanes fly into the World Trade Center towers in New York in 2001.
"It was heavily charged, emotionally and mentally," Kruschke said of his deployment to New York after the attacks there. "We did a lot of cuts and bruises with the people that were working, but more importantly, we did a lot of talking and listening."
Those teams are made up of people who do clinical care every day, and who want to serve, Garrett said.
"I never like to say this, but most of these folks would do it for free. This is how we have chosen to serve," he said.


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Job Overview
Why is it Great to Work for the Federal Bureau of Prisons?
Do your career justice and consider a career with the Federal Bureau of Prisons (BOP). In addition to being regarded as a family and career-oriented agency, the BOP offers a broad range of exciting career opportunities in a work environment that promotes integrity, diversity, and professional development. With over 38,000 highly motivated individuals, the Federal Bureau of Prisons is one of the most unique agencies in the United States Department of Justice where each employee's day-to-day performance makes a difference.
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Manages the daily operation of the outpatient/inpatient departments and conducts daily sick call.
Performs comprehensive physical and psycho social assessment including health maintenance screening and risk evaluation. Identifies behaviors and environmental factors affecting health/illness. Encourages lifestyles that maintain and support wellness through patient education and counseling, and assists patients in becoming active participants in personal health.
Along with all other correctional institution employees, incumbent is charged with responsibility for maintaining security of the institution. The staff correctional responsibilities precede all others required by this position and are performed on a regular and recurring basis.
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