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Eclectic Institute, Cayenne, 1 fl oz (30 ml)
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Expiration Date:?May 2021Expiration Date
The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand.
Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.
Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. However, discrepancies do occur from time to time. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry.
Shipping Weight:?0.25 lbsSwitch to Metric units
- Product Code: ECL-10128
- UPC Code: 023363101283
- Package Quantity: 1 fl oz (30 ml)
1.3 x 1.3 x 4 in, 0.15 lbsSwitch to Metric units
|Combo Discount:
|- $2.00
- Grain-Free Alcohol
- Since 1982
- Herbal Extract
- Dietary Supplement
- Capsicum Annuum Fruit
- 250 mg/ml Herb Equivalency
- Non-GMO
- Gluten/Soy/Dairy-Free
- Full Strength
- Vegan
- Organic Alcohol
Suggested Use
Shake well; mix 15-30 drops in water; take 1-3 times daily.
Other Ingredients
Dried cayenne (capsicum annuum) fruit 90,000 HU, organic grain-free alcohol content: 70-80%, filtered water. Dry herb strength: 1:4 (250 mg/ml).
Discontinue if unusual symptoms occur. Consult your health care advisor regarding the use of herbs during pregnancy, with infants or with prescription drugs.
Store upright. Keep out of reach of children.
Very Hot. As to be expected
Verified Purchase
Very Hot. As to be expected
I read in a doctor book that if he had to choose one single herb this would be the one. I also agree as a user. You can really feel it working. lol. I have been using 15 drops on orange juice. Stir well to disolve. I like the alcohol used to keep it fresh (as customery for herbal products presented in liquid form), instead of other chemicals, preservatives. If concerned with that (much less than what is in a glass of wine (good for you!)). Then put it on a hot tea and let the alcohol evaporate. Voila in 5 min you get the alcohol free version. There is always someone to complain. It seems this is helping the digestive system flush out well as I had quite a few bowel movements within 48 hours. I like that already.
Super spicy
Posted by 5262462037184150319 on Dec 27, 2016
Super spicy
Uhm, so spicy...
Posted by Yufong on Dec 26, 2016
30 drops per cup is really too many, maybe 15drops will be proper.
Ridiculously spicy
Posted by Reviewer2492424 on Dec 16, 2016
Burned the inside of my mouth with this, even though I like spices and have some tolerance. Can't figure out what to add it to without making it too spicy. I may have gotten a bottle with an abnormally large percentage of cayenne. It is either poor quality control, or the product is simply too spicy to make it practical to ingest. I read that it is so good for you, so I really want to like this but just can't take it without suffering chemical burns in my mouth!
Posted by 5247239512278749389 on Aug 20, 2016
It's great that this product can be used in more ways than one. Believe it or not I was looking for a lizard/bug repellent and was searching for liquid pepper/cayenne and I saw this... I mix a few drops of this with a few drops of peppermint essential oil and water in a spritz bottle and spritz it at my window seals and no house lizards ever visit..
Great to have to stop a heart attack just in case.
Posted by Reviewer1878151 on Jul 10, 2016
Google this stops a heart attack!


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By Melanie Nayer
It started with my first cup of coffee. The foam on my latte was perfectly placed on top of the steaming brown cup of brewed beans. The barista finished off my much-needed caffeine fix with a heart in the center of the cup and asked me for me 2 euros. I wasn't in Rome for one hour and already love was being thrown in my face, and it was in my coffee – the only thing I needed to turn me from sleepless psycho woman to life of the party.
The trip to the Rome wasn't exactly planned, but we had the miles and the money and off we went. My travel friend had last been to Rome with her husband – on their honeymoon. I had heard about Rome – its the city in Italy filled with tall, dark and gorgeous men who waltz down sultry streets with perfectly toned women draped in Valentino and Versace. Standing 5'3" and hardly the fashion icon, I wasn't all too eager to experience the romantic spots and candle-lit corners that would taunt me all the way back to my hotel room. Alone. In my single bed. Where I slept in Rome. Alone. Single.
But surprisingly, Rome took a turn for the interesting…
A tip for those women traveling alone who dare to visit the Eternal City: be careful because before you know it, you'll be strutting down the Via Conditti with all the confidence of a supermodel in stilettos.
Before my first day in Rome came to an end, I was suddenly swept away by the friendly faces, warm smiles and kind gestures of just about everyone you meet. I ordered my first glass of Barolo at the lobby cafe in the Hotel Homs and settled into the night. People of all types walked down the cobblestone street that circled the hotel and most of them nodded, smiled or offered a "buongiorno" as they passed by.
Upstairs on the Spanish Steps we sipped bellinis and watched the tourists crowd the popular attraction. Our waiter, Antonio, was of the tall, dark and handsome persuasion. He attended to our every beverage requirement and did so with a wink and smile – just enough to make a woman blush, but not so far to make her feel uncomfortable. Romantic? It could be. But not the type of romance that makes you weep. The kind of romance that makes you believe in romance.
No, I wasn't kissed on the Spanish Steps, I wasn't whisked away on a Vespa, and I didn't buy a villa or start harvesting olives for my own brand of olive oil. But, while in Rome, I did discover something: my sexy side. Not that kind of sexy – the kind of sexy that exudes self-confidence and self-assurance.
Single and in my mid-30s, you would think by now I would have discovered 'me.' Still, the typical adjectives followed my name: Not-married, childless, career-focused, gypsy. While they are descriptive, I've never had a strong association to any of them. True, I have no children and I'm not married or in a serious relationship. I've spent the past decade focused solely on my career, and yes, I'm a bit of a gypsy (but in a modern day sense). I take the road less traveled and will pick up and go at an instant, but I know my home and I'm faithful to my roots.
And then came Rome. In this little Italian epicenter, I finally found me: and I felt great.
A few must-do's while you're here that are sure to bring out the sexy side of you:
• Everything starts a little later in Europe. The fashionable dine at 10 p.m. so cocktails start around 8. Don't worry about drinking too much before dinner – the cafes serve antipastos and appetizers free of charge with your drinks. Mix and mingle with the locals and you might find yourself at one of Rome's best-kept secret restaurants.
• Pledge to buy yourself something truly fabulous. Nothing makes a single woman feel glamorous like a new Italian leather handbag or a pair of soft leather gloves. I left Rome with a silk scarf and every time I wear it, I get an added burst of confidence in my step.
• To really connect with Rome, ask one of the artist's in the Piazza Navona to paint you a picture. They'll happily oblige (for a small fee) and you'll have a one-of-a-kind piece of art to take home.
• Spend one day touring all the must-see sites including the Pantheon, the Colosseum, the art museums and Vatican City. Then, spend an entire day relaxing at an outdoor café. You'll experience the best of both worlds and learn more about the culture, people and history with a little time spent in the past and present.
• When the beautiful man in the black suit and silk tie tips his hat and says, "Ciao Bella", smile back and offer up a "Ciao." You'll know who he is when you see him, and trust me: it's the sexiest "Ciao Bella" you'll ever get.
My 'me' moment came around 3 p.m. on June 10, 2008. The spa was nestled somewhere between the Pantheon and one of the millions of cafes, tucked away in a hidden street you can only find on foot. Lying naked on a massage table in Rome, I realized the inhibitions that plagued me had magically been erased.
Rome is full of romance, but not the kind that makes you feel single and alone – it's the kind of romance that envelops you, and that beckons you to love back.
Melanie Nayer is a travel enthusiast and expert. Her articles have been published in leading newspapers, magazines and online publications including the Boston Globe, Fortune Magazine, Boston.com, NYT.com, and various in-flight airline magazines.
More Great SMW Travel Articles
Immersion Travel: Learn How to Mush
A Traveler's Gift Guide
April is National Volunteer Month: Where Are You Volunteering?
Become an Immersion Traveler

subset: commoncrawl


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12 New York, USA
The Big Apple may appear a young person's place, but more than 12 per cent of residents are 65-plus. Condominium blocks and co-ops are favoured by older buyers because of their community atmosphere. The city that never sleeps still has a buzz, however. It is perfect for retirees with no intention of slowing down. Prices are high – they rose one per cent in 2012, and a typical home now costs £506,750, says the Real Estate Board of New York.
Insider Tip If you buy a condominium in a Manhattan co-op, you must be "voted in" by other residents. So don't move across until you are accepted.
For Sale This brownstone in Brooklyn has six bedrooms, but is split into three apartments. £2m through Sotheby's (001 718 638 6500).


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Hey im tottaly confused why booksie never has a alphabetical order of fanfictions but they don't.....So if your a natsuku fan please email me or commet below if you wanna start a fan-club.! And i'll be picking out a vice-president and a club organizer since i can't handle all this myself :p and please join my fanclub.And once i get 12 fans to join ill make a fan-page so---???????BAI :3
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I think silver may knows it, maybe ask her :P but idk that, srry
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text: Create Some Unlikely Things You'd See in Google Street ViewAdam Frucci2/05/09 4:00pmFiled to: Photoshop ContestPhotoshopContestsGoogleGoogle Mapsstreet viewSimpsons50EditPromoteShare to KinjaToggle Conversation toolsGo to permalink We're always finding strange things in Google Street View. But there are some things that, chances are, we'll never, ever see using the service. Let's change that. For this week's Photoshop Contest, I want you to come up with some ridiculous things that we'll never see using Google Street View. I'll leave that pretty open to interpretation, so feel free to go crazy. Advertisement Advertisement Send your solutions to me at email@example.com with "Fake Street View" in the subject line. Save your files as a JPG, PNG or GIF, and use a FirstnameLastname.jpg naming convention, using whatever name you want to be credited as. Send in your entries by next Tuesday morning, and I'll through them and pick the winners and put the best of the rest in our Gallery of Champions. Get to it!Reply50 repliesLeave a reply


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Mapping seizure susceptibility loci in mice provides a framework for identifying potentially novel candidate genes for human epilepsy. Using C57BL/6J × A/J chromosome substitution strains (CSS), we previously identified a locus on mouse chromosome 10 (Ch10) conferring susceptibility to pilocarpine, a muscarinic cholinergic agonist that models human temporal lobe epilepsy by inducing initial limbic seizures and status epilepticus (status), followed by hippocampal cell loss and delayed-onset chronic spontaneous limbic seizures. Herein we report further genetic mapping of pilocarpine quantitative trait loci (QTLs) on Ch10.
Seventy-nine Ch10 F2 mice were used to map QTLs for duration of partial status epilepticus and the highest stage reached in response to pilocarpine. Based on those results we created interval-specific congenic lines to confirm and extend the results, using sequential rounds of breeding selectively by genotype to isolate segments of A/J Ch10 genome on a B6 background.
Analysis of Ch10 F2 genotypes and seizure susceptibility phenotypes identified significant, overlapping QTLs for duration of partial status and severity of pilocarpine-induced seizures on distal Ch10. Interval-specific Ch10 congenics containing the susceptibility locus on distal Ch10 also demonstrated susceptibility to pilocarpine-induced seizures, confirming results from the F2 mapping population and strongly supporting the presence of a QTL between rs13480781 (117.6 Mb) and rs13480832 (127.7 Mb).
QTL mapping can identify loci that make a quantitative contribution to a trait, and eventually identify the causative DNA-sequence polymorphisms. We have mapped a locus on mouse Ch10 for pilocarpine-induced limbic seizures. Novel candidate genes identified in mice can be investigated in functional studies and tested for their role in human epilepsy.
The importance of genetic factors in epilepsy is well accepted, but the specific genes responsible have been identified for only a few rare Mendelian epilepsy syndromes in humans (Winawer & Shinnar, 2005; Baulac & Baulac, 2010). The difficulty in finding genes results in part from the fact that most epilepsy is "complex," with multiple genetic, nongenetic, and possibly interacting causes, and temporal lobe epilepsy (TLE) exemplifies this problem (Mathern et al., 1996; Cendes et al., 1998; Semah et al., 1998; Engel, 2001; Fuerst et al., 2001; Kobayashi et al., 2001; Stephen et al., 2001; Ottman, 2005; Santos et al., 2002; Vadlamudi et al., 2003; Scharfman & Pedley, 2006). Epilepsy is also heterogeneous because of the variety of underlying biologic processes that may give rise to seizure susceptibility and act as potential therapeutic targets.
Mapping seizure susceptibility loci in mice provides a framework for identifying potentially novel candidate genes for complex human disorders (Frankel, 2009). Prolific breeding and short gestation expedite genetic linkage methods (Palmer & Phillips, 2002; Phillips et al., 2002), and the availability of genetic maps and sequence data for multiple inbred strains also facilitate genetic research in mice. Conservation of genes from mouse to human genomes allows genetic discoveries in the mouse to be translated for study in human populations.
Inbred mouse strains differ in susceptibility to develop seizures and seizure-induced hippocampal damage in response to many different convulsant stimuli, and these differences have been shown to be heritable ((Neumann & Collins, 1991, 1992; Ferraro et al., 1995, 1997; Schauwecker & Steward, 1997; Ferraro et al., 1998; Gershenfeld et al., 1999; Hain et al., 2000; Schauwecker, 2002; McKhann et al., 2003; Frankel, 2009). The A/J strain has been shown to be more susceptible than B6 to most (though not all) types of convulsant stimuli (Kosobud & Crabbe, 1990; Mathis et al., 1994; Gershenfeld et al., 1999; Golden et al., 2001; Ferraro et al., 2002), and has recently been described to have sleep-related spontaneous seizures (Strohl et al., 2007). Genetic variation among strains is presumed to be a result of functional polymorphisms in genes that affect the threshold for neuroexcitability in response to exogenous stimuli (Frankel et al., 2001). Identifying these genes can provide insight into epilepsy pathophysiology and lead to improved and novel therapeutic strategies.
Quantitative trait loci (QTL) are genomic loci that make a quantitative contribution to a trait, such as seizure susceptibility. QTL mapping can identify these loci, and eventually the causative DNA-sequence polymorphisms. This powerful strategy is designed specifically to investigate oligogenic models, in which several genes of small to moderate effect act to influence a trait. Chromosome substitution strains (CSS) are strains in which a single chromosome from one inbred strain (donor) has been transferred onto a second strain (host) by repeated backcrossing, and provide an invaluable resource for mapping mouse QTLs. Chromosome substitution strain analysis provides quick and efficient localization at the chromosomal level without the need for cross-breeding or genotyping (Nadeau et al., 2000). Using C57BL/6J (B6, host) × A/J (donor) CSS, we recently identified contributions to susceptibility to pilocarpine-induced seizures on mouse chromosomes 10 and 18 (Winawer et al., 2007).
Pilocarpine, a muscarinic cholinergic agonist, induces initial severe continuous limbic seizures (status epilepticus) in rodents, followed by cell loss similar to that observed in TLE, and delayed onset of chronic spontaneous limbic seizures (Turski et al., 1989; Turski, 2000; Leite et al., 2002; Borges et al., 2003). Prior to our report (Winawer et al., 2007), limbic seizures had not been studied in the A/J strain, and susceptibility to pilocarpine-induced seizures had not been studied with QTL mapping. Herein we report fine mapping of a pilocarpine seizure susceptibility locus on mouse chromosome 10 (Ch10), using F2 mouse populations and interval-specific congenic strains. (See Methods for breeding scheme details.)
A/J, B6, and CSS breeder pairs were purchased from the Jackson Laboratories (Bar Harbor, ME, U.S.A.), and colonies of each strain, F1s, F2s, and congenics were bred in our laboratory. Mice were housed in a temperature- and humidity-controlled environment, with a 12-h light/dark schedule and food and water available ad libitum. Only male animals were tested for seizure susceptibility, to avoid estrus cycle effects on seizure susceptibility, and animals were tested at between 10 and 11 weeks of age. All methods were approved by the Institutional Animal Care and Use Committee of Columbia University and met the guidelines of the National Institutes of Health (NIH).
To investigate the mode of inheritance of the Ch10 susceptibility locus, we bred the CSS10 males—chromosome substitution strain mice containing Ch10 of A/J on a B6 background—with B6 females. We also tested 10F1 animals—the first generation offspring from a cross of CSS10 females with CSS10 males—for seizure susceptibility. F1 animals appeared to have intermediate seizure susceptibility between that of B6 and CSS10 animals, suggesting an additive mode of inheritance. We, therefore, bred CSS10 males with B6 females to produce a Ch10 × B6 F1 generation, and intercrossed these animals to produce the CSS-10 × B6F2 mapping population (n = 79). The genders of the CSS10 and B6 animals in the first cross were specified in order to limit potential variability from imprinting.
We created Ch10 interval-specific congenic strains by breeding successive rounds of littermates selectively by genotype in order to isolate subregions of A/J Ch10 on a B6 background. We began this process by using genotyped CSS-10 × B6F2 mice, selecting mice heterozygous for an A/J Ch10 segment of interest, and breeding them with B6 animals. Heterozygous offspring from these crosses were then brother–sister mated to produce a first round of congenics. These mice were genotyped, and subsequent generations were bred selectively by genotype to isolate the region of interest. Heterozygote mating was used to perpetuate congenic lines, and to create B6 homozygous littermate controls for comparison. Fig. 1A illustrates the panel of congenic strains used in the analyses presented here, and Fig. 1B the marker positions in Mb.
Animals were weighed immediately prior to seizure testing, and pilocarpine dose was calculated based on this weight. Animals were injected with intraperitoneal (i.p.) pilocarpine hydrochloride (Sigma-Aldrich, St. Louis, MO, U.S.A.). A dose of 250 mg/kg was used for the CSS-10 × B6F2 mapping population, and a dose of 300 mg/kg was used for all congenic studies. We increased the dose from 250–300 mg/kg to accentuate differences between congenic and control phenotypes and facilitate fine mapping. All seizure susceptibility testing was performed between the hours of 12:00 and 5:00 p.m. to limit any effects of diurnal variation on results (the light cycle begins at 7 a.m. and ends at 7 p.m. in our facility). To limit peripheral side-effects, 30 min before pilocarpine injection, all mice were given atropine methyl nitrate (5 mg/kg, i.p., TCI America, Portland, OR, U.S.A.), a competitive muscarinic acetylcholine receptor antagonist that does not cross the blood–brain barrier. CSS-10 × B6F2 animals were observed continuously for 3 h. In the course of seizure susceptibility testing, we found that over observation of >550 animals, 99% progressed to their highest stage by 2.5 h. We, therefore, subsequently shortened our observation period from 3 to 2.5 h for all congenic animals. The time of onset and offset for each seizure stage was recorded in minutes from time of pilocarpine injection. From these data we extracted the highest stage reached, the proportion of animals having generalized seizures (reaching stage 4 or higher), duration of stages, and latency to reach each stage (see Table 1 for seizure staging). We used a seizure staging system adapted from established rodent seizure scales (Racine, 1972), as described previously (Winawer et al., 2007), with several modifications.
Since our last publication, we have further refined seizure scoring, adding intermediate levels between stages 3 and 4 and between 4 and 5 (Table 1). The intermediate seizure stages we have added are reliably identified by our observation protocol, and were developed after observation of more than a thousand mice. More detailed phenotyping allows better discrimination among animals with different degrees of seizure susceptibility.
We mapped two variables in the CSS-10 × B6F2 population: time spent in stage 3, which corresponds to the duration of continuous partial seizures, or partial status epilepticus, and highest stage reached, which corresponds to the most severe seizure stage attained. Use of these two variables captures both latency to and severity of pilocarpine-induced seizures, two essential measures of susceptibility.
After mapping both phenotypes with confidence to the same region on distal Ch10, we used a dichotomous version of highest stage reached, whether an animal reached stage 4 or higher (had generalized seizures) for fine mapping in congenic strains. Stage 4 is reliably identified in mice, and occurred more frequently in our congenic animals because of the higher dose used for testing (300 mg/kg) compared with CSS-10 × B112 animals (250 mg/kg). We also performed analyses with the original phenotypes, time in stage 3 and highest stage reached, for comparison.
We used the Qiagen DNAeasy kit (Qiagen Sample and Assay Technologies, Germantown, MD, U.S.A.) to extract DNA from mouse tail and spleen. F2 mice were genotyped at six polymorphic single-nucleotide polymorphism (SNP) markers that were evenly spaced across chromosome 10 (rs13480530, rs13459120, rs13480621, rs13480643, rs13480719, and rs13480781.) For congenic line construction, in order to further saturate the region of interest, we used rs13480832 as well (Fig. 1). Genotyping was performed at the University of Chicago using the ABI TaqMan Assay (Applied Biosciences, Foster City, CA, U.S.A.) and a Step One PCR (polymerase chain reaction) machine (Applied Biosciences) in accordance with the manufacturer's instructions.
We used the R/QTL software (Version 1.14-2; http://www.rqtl.org/) (Broman et al., 2003), which runs in the R software environment (Version 2.9.2; http://www.r-project.org/) to map susceptibility loci in the F2 population. R/qtl is essentially a linkage program used for complex trait analysis, and calculates a logarithm of the odds (LOD) score, providing evidence for linkage of a trait of interest to a chromosomal region delineated by genetic markers. To map the variable time spent in stage 3 (partial status epilepticus), we used the "normal" model and the "EM algorithm" method with the age and weight of the mice as covariates. For highest stage reached, we used the nonparametric "np" model and the "EM algorithm" method (nonparametric models do not accommodate covariates). We used 1,000 permutations of these data using the "perm" argument in the scanone function in R/qtl to estimate significance (Churchill & Doerge, 1994). Confidence intervals were calculated using a Bayesian method as implemented in R/qtl. The effect of genotype at the most associated marker was estimated using "effect plot" function in R/qtl. We empirically estimated the distance between markers and additionally estimated genotype at 1 cM intervals between each marker using R/qtl.
In order to fine map the QTL contributing to seizure susceptibility on distal Ch10, analyses were carried out for which attaining stage 4 or higher was the outcome variable, and only animals homozygous at all four loci—rs13480643, rs13480719, rs13480781, and rs13480832—were included. Three sets of analyses were carried out. In the first set, interval-specific congenic strains defined by their genotype profile at the four loci were compared separately from the control animals using a chi-square statistic. In the second, a chi-square statistic was used to compare animals with the AJ genotype at an SNP to animals with the B6 genotype, separately for each of the loci. In the third set, a multiple logistic regression analysis of reaching stage 4 or higher was carried out to narrow the susceptibility region further, including genotypes at the top markers as predictors.
R/qtl analysis of the F2 mice identified significant QTLs for the variables time in stage 3 and highest stage reached. For time in stage 3 (Fig. 2A), there was a highly significant QTL in the distal portion of chromosome 10 that was nearest to marker rs13480719. The Bayes 95% confidence interval for this QTL spanned from 43–60 cM, with a maximum LOD score of 5.34 at rs13480719. The QTL for time in stage 3 accounted for approximately 27% of the variance for this trait in the F2 population. The effect of this QTL appeared to be approximately additive (Fig. 2B). In other words, there is a relatively linear effect of gene dose on phenotype, with the heterozygote phenotype being intermediate to the two homozygotes (B6/B6 and A/A) at the top locus. Results were similar if the covariates were not included in the model, but we included them a priori to be consistent with other analyses.
For highest stage reached (Fig. 3A) there was a highly significant QTL that was also in the distal portion of chromosome 10 and was nearest to marker rs13480781, with a maximum LOD score of 2.99 at marker rs13480781. The QTL for highest stage reached accounted for approximately 16% of the variance for this trait in the F2 population. The Bayes 95% confidence interval for this QTL spanned from 45 cM until the last marker in our map (rs13480781). The effect of this QTL also appeared to be approximately additive (Fig. 3B). Although not formally tested, we hypothesize that loci for time in stage 3 and highest stage reached reflect the pleiotropic action of a single QTL. Although these methods are robust to deviations from normality in the sample, we repeated the rQTL analyses using nonparametric (np) methods to account for nonnormality. All results were quantitatively similar (not shown).
As described above, we performed analyses in which reaching stage 4 or higher was the outcome variable. The first set of analyses, which compared each interval-specific congenic strain (ISCS) with the B6 control animals, resulted in statistically significant evidence for differences between strain and control for congenic strains R2, R3, and R4 (Fig. 1A–C; Tables 2 and and3).3). These results were replicated for the variables of time in stage 3 and highest stage reached (data not shown). The second set of analyses, which examined the effect of genotype at each marker locus separately, resulted in statistically significant evidence for association at rs13480781 and rs13480832. Finally, logistic regression analyses were performed to identify the interval most likely to harbor the susceptibility locus (data not shown). This third analysis examined the effects of multiple loci simultaneously. Regression analyses demonstrated statistically significant evidence of an association with rs13480781 after adjusting for rs13480832, and statistically significant evidence for an association with rs13480832 after adjusting for rs13480781. The association with rs13480719 did not persist after adjusting for rs13480781. This method is comparable to one recently described (Shao et al., 2010). These results correspond to the presence of a trait locus between rs13480781 and rs13480832. We repeated all analyses using logistic regression and adjusting for covariates of mouse age and weight at testing. Results were quantitatively similar (data not shown).
The purpose of this study is to explore the genetics of seizure susceptibility by identifying the loci contributing to susceptibility in a mouse model. This has potentially powerful implications for understanding the genetic contributions to human epilepsy. Using mouse CSS, Ch10 F2 populations, and ISCS, we have identified and fine mapped a locus on distal mouse chromosome 10 (Ch10) that contributes to limbic seizure susceptibility. Mapping of pilocarpine-induced seizures has not been reported previously, and there have been few prior reports of seizure susceptibility candidate loci on mouse Ch10 or syntenic human regions. Gershenfeld et al. reported an association of D10Mit180 (117.59 Mb) with seizure susceptibility in a B6 × A/J cross, in response to β-CCM, a γ-aminobutyric acid (GABA)ergic agent that produces generalized (not limbic) seizures (Gershenfeld et al., 1999). Subsequent studies of a congenic have suggested that this QTL may play a role in both anxiety-related endophenotypes and seizure susceptibility (Zhang et al., 2005).
We have also found evidence for the presence of a locus underlying both seizure susceptibility and anxiety endophenotypes on A/J Ch10 (Ponder et al., 2007; Winawer et al., 2007). In an independent dataset we have confirmed the location of this QTL, using a fear-conditioning paradigm (Palmer A, unpublished results). The possibility that a single allele pleiotropically influences both traits should be investigated further, especially in light of the known comorbidity between psychiatric disorders and epilepsy (Winawer & Hesdorffer, 2010). The region on distal Ch10 may contain one or more loci that play a role in epilepsy and psychiatric comorbidity.
D10Mit180 is located at approximately 117.59 Mb on Ch10, near marker rs13480781, which is located at 117.56 Mb (Fig. 1B). Marker rs13480719 maps to a homologous region on human CH12q. This may overlap a locus on chromosome 12q22–23, which has been found to be linked to familial TLE with febrile seizures in a single extended pedigree (Claes et al., 2004). To our knowledge, no other potential epilepsy genes have been mapped to this region.
We have mapped two seizure susceptibility phenotypes to the same region of mouse Ch10. The first, time in stage 3, is a measure of latency, or duration of partial status. The second, highest stage reached, is a measure of seizure severity. The colocalization of the latency and severity aspects of susceptibility suggests that this QTL has a broad effect on seizure susceptibility across different parameters. Defects in some molecular or biochemical pathways may act to prolong seizures once initiated, whereas others may affect the mechanism of propagation from partial to generalized seizures. Identification of genes that raise risk for one or both mechanisms can give insight into the biology of seizure susceptibility and development of targeted therapies.
These results may be limited, in that they map seizure susceptibility in response to an acute stimulus, not epilepsy. However, identification of genes influencing seizure susceptibility is fundamental to understanding human epilepsy (Noebels, 2003). For example, mutagenesis in a mouse model identified a single mutation on mouse Ch2, Szt1, conferring susceptibility to electroconvulsive threshold (ECT) minimal clonic seizures (Yang et al., 2003). Two of the three known deleted genes—Kcnq2 and Chrna4—are known to be mutated in human epilepsy families (Singh et al., 1998; Steinlein, 2000), and Kcnq2 haploinsufficiency was shown to determine the Szt1 susceptibility phenotype. These results demonstrate a direct correspondence between mouse seizure susceptibility genes and human epilepsy genes. Furthermore, screening compounds for seizure susceptibility in rodents has led to the development of many effective anticonvulsant agents (Frankel, 2009). Even if specific genes identified do not raise risk for epilepsy per se, the information obtained will still be valuable for elucidating the pathophysiology of seizures and therapeutic targets.
The identification of mouse QTLs and quantitative trait genes (QTGs) can provide a framework for identifying novel homologous candidate genes for human epilepsy. This has been demonstrated by the identification of a maximal electroshock seizure threshold (MEST) locus on mouse chromosome 1 (Ch1), fine mapping, selection of a potassium channel candidate gene, Kcnj10, and subsequent discovery of genetic association in a human epilepsy population (Ferraro et al., 2001; Buono et al., 2004; Ferraro et al., 2004). Mutations in Kcnj10 have also been reported in families with epilepsy, sensorineural deafness, and renal tubulopathy, supporting the gene's role in cellular homeostasis in humans (Bockenhauer et al., 2009; Sala-Rabanal et al., 2010). Improving prior probability by the identification of biologically probable candidates can help minimize the false-positive results that plague human genetic association studies (Cardon & Bell, 2001; Emahazion et al., 2001) We have previously demonstrated success translating from mouse QTL to human genetic association with the identification of CSNK1E, a candidate gene for methamphetamine sensitivity in both mice and humans (Veenstra-Vander-Weele et al., 2006). QTL mapping is a powerful technique with the potential to identify novel loci and genes involved in epilepsy and other human complex disorders.
Analysis of chromosome substitution strains, Ch10 F2 populations, and ISCS created to date provides strong evidence for a seizure susceptibility locus on distal mouse Ch10 between markers rs13480781 and rs13480832. Further congenic strain creation is underway, and will help improve the resolution of our mapping and narrow the list of potential candidate genes.
Supported by grants NS061991 and MH079103. Technical laboratory support was provided by Shazeda Khan.
None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Week in history: Ducks beat L.A. to hockey nirvana
If you pay any attention at all to professional ice hockey, or sports in Southern California, you know that the Los Angeles Kings are playing for the Stanley Cup.
The team is up 2-0 on the New Jersey Devils, and back at Staples Center for the next two games.
So far, so good.
But if they win it all the Kings will only be the second team from California to hold up Lord Stanley's cherished trophy in triumph.
Five years ago this week, the Anaheim Ducks beat the Ottawa Senators on their home ice at the Honda Center to become the 2007 National Hockey League champs. They did it in five games. Can you beat that Kings?
Taking our cue from the Ducks, we're going to look at other sorts of triumphs for our latest This Week in History. But, life being what it is, we can't ignore certain tragedies that also took place.
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Though the even officially kicks off on Thursday, Friday is when Comic-Con normally shifts into high gear. The 2013 installment of the annual convention is no different, with several big ticket panels filling up the day.
Though the news was leaked early by series creator George R. R. Martin, "Game of Thrones" is on the scheduled as returning to the San Diego Comic-Con. It'll be joined by other TV standouts like "The Walking Dead," "Marvel's Agents of SHIELD," "Bones," "The Following," "Falling Skies," and a pilot screening and panel for "Almost Human."
As for movies, Sony and Screen Gems will have a two-hour panel that will include "The Amazing Spider-Man 2," "Robocop," "Cloudy with a Chance of Meatballs 2" and "The Mortal Instruments: City of Bones." "Veronica Mars," "Kick-Ass 2" and "Riddick" will also have a presence.
The full schedule is available at the Comic-Con website, but you can check out movie and TV highlights below:
"The World's End" (10 – 11 a.m., Hall H): Stars Simon Pegg and Nick Frost join director Edgar Wright to talk about their latest movie, and look back on their trilogy (including "Shaun of the Dead" and "Hot Fuzz").
"Defiance" (10:30 – 11:30 a.m., Room 6a)
Stars Grant Bowler, Julie Benz, Jaime Murray and the rest of the cast talk about the crossover TV show/video game.
"Veronica Mars" (11:15 a.m. – 12:30 p.m., Hall H): Stars Kristen Bell, Francis Capra, Enrico Colantoni, Percy Daggs III, Jason Dohring, Ryan Hansen, Chris Lowell, Tina Majorino and Krysten Ritter and director Rob Thomas discuss their Kickstarter-funded movie and show a video presentation.
"Nikita" (11:30 a.m. – 12:30 p.m., Room 6BCF): Stars Maggie Q (Mission: Impossible 3), Shane West (ER), Lyndsy Fonseca (Kick-Ass), Aaron Stanford (X-Men: The Last Stand), Melinda Clarke (The O.C.), Devon Sawa (Final Destination), and Noah Bean (Damages) take the stage with executive producer Craig Silverstein for a farewell panel discussing the show's final season.
Universal Pictures (12:15 – 1:15 p.m., Hall H): Universal brings two movies to Comic-Con. "Riddick" will present stars Vin Diesel (Fast & Furious 6), Katee Sackhoff (Battlestar Galactica) and Dave Bautista (The Man with the Iron Fists), and director David Twohy. "Kick-Ass 2" will also feature cast and crew, though no names have been announced.
"Bones" (12:30 – 1:30 p.m., Ballroom 20): Creator Hart Hanson and executive producer Stephen Nathan join star Davis Boreanaz to discuss the show's next season and present never-before-seen footage.
"The Walking Dead" (1:35 – 2:30 p.m., Hall H): Stars Andrew Lincoln, Norman Reedus, Steven Yeun, Lauren Cohan, Danai Gurira, David Morrissey, Scott Wilson and Chad Coleman are joined by executive producers Scott Gimple, Robert Kirkman, Gale Anne Hurd and Dave Alpert discuss what to expect from season four of the show, along with a sneak preview.
"Marvel's Agents of SHIELD" (1:45 – 3:00, Ballroom 20): Jeph Loeb, Joss Whedon and surprise guests will discuss the live-action series.
"Game of Thrones" (2:50 – 3:45 p.m., Hall H): Stars John Bradley, Emilia Clarke, Nikolaj Coster-Waldau, Peter Dinklage, Michelle Fairley, Kit Harington, Rose Leslie and Richard Madden will be joined by executive producers David Benioff and D.B. Weiss, along with creator George R. R. Martin, discuss what's next for the HBO hit.
"The Following" (3:15 – 4 p.m., Ballroom 20): Stars Kevin Bacon (Mystic River), Shawn Ashmore (X- Men: The Last Stand) and Valorie Curry (The Twilight Saga: Breaking Dawn Part 2) join executive producer Marcos Siega for a Q&A and video presentation.
"Almost Human" (4 – 5 p.m., Ballroom 20): The pilot for the upcoming FOX show will be screened, followed by a Q&A with producers and stars of the series.
"Bob's Burgers" (4 – 5 p.m., Indigo Ballroom Hilton Bayfront Hotel): Stars H. Jon Benjamin, Dan Mintz, Eugene Mirman, John Roberts, Kristen Schaal and Larry Murphy are joined by executive producers Loren Bouchard and Jim Dauterive to answer fan questions and show never-before-seen footage of the animated comedy.
Sony and Screen Gems (4:05 – 6:15 p.m., Hall H): Four movies are scheduled to be showcased during the two-hour panel. "Cloudy with a Chance of Meatball 2" presents stars Anna Faris and Terry Crews, as well as directors Cody Cameron and Kris Pearn. "The Mortal Instruments: City of Bones" brings stars Lily Collins, Jamie Campbell Bower, Robert Sheehan and Kevin Zegers, along with director Harald Zwart and best-selling author Cassandra Clare. "Robocop" will feature director Jose Padilha and stars Joel Kinnaman, Abbie Cornish and Samuel L. Jackson. No cast has been announced for "The Amazing Spider-Man 2" yet, but expect Spidey himself, Andrew Garfield, to be in attendance.
"Falling Skies" (4:30 – 5:30 p.m., Room 6BCF): Noah Wyle, Moon Bloodgood, Will Patton, Drew Roy, Collin Cunningham, Sarah Carter, Conner Jessup and Doug Jones join executive producers Remi Aubuchon and Greg Beeman are participating in the panel, answering questions and showing never-before-seen footage.
"Archer" (5 – 6 p.m., Indigo Ballroom, Hilton Bayfront Hotel): Voice actors H. Jon Benjamin (Bob's Burgers), Aisha Tyler (The Talk), Chris Parnell (30 Rock), Judy Greer (Arrested Development), Amber Nash (Frisky Dingo), and Lucky Yates (Good Eats) and executive producers Adam Reed and Matt Thompson discuss the popular animated series.


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K. Kawata, University of Tokyo Institute for Cosmic Ray Research.
A map of the northern sky shows the concentration of ultrahigh-energy cosmic rays stemming from the constellation of Ursa Major.
NASA, ESA, and the Hubble Heritage Team (STScI/AURA)
To celebrate its 23rd year in space, the Hubble Space Telescope snapped this view of the famous Horsehead nebula in infrared light. Usually obscured by the thick clouds of dust and gas, baby stars can be seen cocooned inside this stellar nursery. For the last 23 years, Hubble has been looking deep into the Cosmos returning over a million observations of nebular such as this, but also planets, exoplanets, galaxies and clusters of galaxies. The mission is a testament to the the human spirit to want to explore and discover. Here are some of our favorite recent observations to come from the veteran mission.
NASA, ESA, J. Rigby (NASA Goddard Space Flight Center), K. Sharon (Kavli Institute for Cosmological Physics, University of Chicago), and M. Gladders and E. Wuyts (University of Chicago).
Light from an ancient galaxy 10 billion light-years away has been bent and magnified by the galaxy cluster RCS2 032727-132623. Without the help of this lensing effect, the distant galaxy would be extremely faint.
Source: http://hubblesite.org/newscenter/archive/releases/2012/2012/08/results/100/
NASA, ESA, and the Hubble Heritage (STScI/AURA)-ESA/Hubble Collaboration
This is 30 Doradus, deep inside the Tarantula Nebula, located over 170,000 light-years away in the Large Magellanic Cloud, a small satellite galaxy of the Milky Way. 30 Doradus is an intense star-forming region where millions of baby stars are birthed inside the thick clouds of dust and gas.
Source: http://hubblesite.org/newscenter/archive/releases/2012/2012/01/results/100/
NASA, ESA, the Hubble Heritage Team (STScI/AURA)-ESA/Hubble Collaboration, and W. Keel (University of Alabama)
NGC 3314 is actually two galaxies overlapping. They're not colliding – as they are separated by tens of millions of light-years – but from our perspective, the pair appears to be in a weird cosmic dance.
Source: http://hubblesite.org/newscenter/archive/releases/2012/2012/29/results/100/
NASA, ESA, and the Hubble Heritage (STScI/AURA)-ESA/Hubble Collaboration
Arp 116 consists of a very odd galactic couple. M60 is the huge elliptical galaxy to the left and NGC 4647 is the small spiral galaxy to the right. M60 is famous for containing a gargantuan supermassive black hole in its core weighing in at 4.5 billion solar masses.
Source: http://hubblesite.org/newscenter/archive/releases/2012/2012/38/image/a/results/100/
NASA, ESA, S. Baum and C. O'Dea (RIT), R. Perley and W. Cotton (NRAO/AUI/NSF), and the Hubble Heritage Team (STScI/AURA)
With help from the Karl G. Jansky Very Large Array (VLA) radio telescope in New Mexico, Hubble has observed the awesome power of the supermassive black hole in the core of elliptical galaxy Hercules A. Long jets of gas are being blasted deep into space as the active black hole churns away inside the galaxy's nucleus.
Source: http://hubblesite.org/newscenter/archive/releases/2012/47/image/a/
NASA, ESA, and the Hubble Heritage Team (STScI/AURA)
The striking Sharpless 2-106 star-forming region is approximately 2,000 light-years from Earth and has a rather beautiful appearance. The dust and gas of the stellar nursery has created a nebula that looks like a 'snow angel.'
Source: http://hubblesite.org/newscenter/archive/releases/2011/2011/38/image/a/results/100/
NASA and ESA
NGC 922 is a spiral galaxy with a difference. Over 300 million years ago, a smaller galaxy (called 2MASXI J0224301-244443) careened through the center of its disk causing a galactic-scale smash-up, blasting out the other side. This massive disruption generated waves of gravitational energy, triggering pockets of new star formation – highlighted by the pink nebulae encircling the galaxy.
Source: http://hubblesite.org/newscenter/archive/releases/2012/2012/45/
NASA, ESA, CXC, SAO, the Hubble Heritage Team (STScI/AURA), and J. Hughes (Rutgers University)
Four hundred years ago a star exploded as a type 1a supernova in the Large Magellanic Cloud (LMC) some 170,000 light-years from Earth. This is what was left behind. The beautiful ring-like structure of supernova remnant (SNR) 0509-67.5 is highlighted by Hubble and NASA's Chandra X-ray space observatory observations. The X-ray data (blue/green hues) are caused by the shockwave of the supernova heating ambient gases.
Source: http://hubblesite.org/newscenter/archive/releases/2012/2012/06/image/a/results/100/
NASA, ESA, and the Hubble Heritage Team (STScI/AURA)
The intricate wisps of thin gas (billions of times less dense than smoke in our atmosphere) from Herbig-Haro 110 are captured in this stunning Hubble observation. Herbig-Haro objects are young stars in the throes of adolescence, blasting jets of gas from their poles.
Source: http://hubblesite.org/newscenter/archive/releases/2012/30/image/a/
NASA, ESA, G. Illingworth, D. Magee, and P. Oesch (University of California, Santa Cruz), R. Bouwens (Leiden University), and the HUDF09 Team
Contained within an area a fraction of the diameter of the moon, astronomers counted thousands of galaxies in the deepest observation ever made by Hubble. Combining 10 years of Hubble observations, the Hubble eXtreme Deep Field (XDF) has picked out galaxies that were forming when the Universe was a fraction of the age it is now.
Source: http://hubblesite.org/newscenter/archive/releases/2012/37/
A hotspot of powerful, ultrahigh-energy particles streams toward Earth from beneath the handle of the Big Dipper constellation. This collection of cosmic rays may help scientists nail down the origin point of the powerful particles, a century-old mystery.
"This puts us closer to finding out the sources — but no cigar yet," Gordon Thomson, of the University of Utah, said in a statement. Thomson is the co-principle investigator for the Telescope Array cosmic ray observatory in southern Utah, which discovered the hotspot, and one of the 125 researchers on the project.
ANALYSIS: Gamma-Ray Burst Blasted 8th Century Earth
"All we see is a blob in the sky, and inside this blob there is all sorts of stuff — various types of objects — that could be the source," he added. "Now we know where to look." [8 Baffling Astronomy Mysteries]
A Hundred-Year-Old Mystery
Gordon worked with an international team of scientists to capture 72 ultarhigh-energy cosmic rays with the Telescope Array over a period of five years. If powerful cosmic ray sources spread evenly across the sky, the resulting waves should also be evenly distributed. Instead, 19 of the detected signals came from a 40-degree circle that makes up only six percent of the sky. The hot spot lies in the constellation Ursa Major, home of the Big Dipper.
ANALYSIS: Using Cosmic Rays To Study Fukushima Reactor
"We have a quarter of our events in that circle instead of 6 percent," collaborator Charlie Jui, also from the University of Utah, said in the same statement.
Jui describes the hotspot's location as "a couple of hand widths below the Big Dipper's handle." The region would appear like any other region of the sky to regular optical telescopes.
According to the researchers, the odds that the hotspot is a statistical fluke rather than real are only 1.4 in 10,000.
Solar-powered detector at the Telescope Array cosmic ray observatory measures the strength and direction of cosmic rays after they travel through Earth's atmosphere. John Matthews, University of Utah
The hotspot region of the sky lies near the supergalactic plane, which contains local galaxy clusters such as the Ursa Major cluster, the Coma cluster and the Virgo cluster.
The research, which is an international collaboration of over 100 scientists, was recently accepted for publication in the Astrophysical Journal Letters.
Discovered in 1912, cosmic rays are thought to consist of the bare protons of hydrogen nuclei, or the centers of heavier elements. The powerful particles stream in from various regions of the sky, with energies reaching as high as 300 billion billion electron volts. Cosmic rays are classified as "ultrahigh-energy" if they carry the energy of 1 billion billion electron volts, comparable to a fast-pitch baseball.
NEWS: Powerful Cosmic Blast Breaks Records
While low-energy cosmic rays come from stars like the sun over the course of their life or explosive deaths, the origins of more energetic rays remain a mystery.
Suggested progenitors for the more powerful cosmic rays include Active Galactic Nuclei (AGN), where material is sucked into supermassive black holes at the center of galaxies, or gamma-ray bursts from the explosive supernova death of massive stars. Other potential causes include shockwaves from noisy radio galaxies and colliding galaxies. More exotic possibilities include the decay of "cosmic strings," hypothetical one-dimensional defects proposed by string theory.
Ultrahigh-energy cosmic rays stem from outside the Milky Way, but are weakened by interactions with the cosmic microwave background radiation — the leftover fingerprint from the Big Bang that kicked off the universe. As a result, 90 percent of the detected ultrahigh-energy cosmic rays originate within 300 million light-years of Earth.
According to Jui, a separate study currently in progress suggests that the distribution of ultrahigh-energy cosmic rays in the northern sky is related to concentrations of large-scale structures like clusters and superclusters of galaxies.
NEWS: NASA Installs Cosmic Ray Hunter on Space Station
"It tells us there is at least a good chance these are coming from matter we can see, as opposed to a different class of mechanisms where you are producing these particles with exotic processes," Jui said.
The Telescope Array houses 523 detectors spread over 300 square miles of desert. Physicists hope to make the observatory more sensitive by doubling the number of detectors and quadrupling the area they cover, which should capture more cosmic rays.
"With more events, we are more likely to see structure in that hotspot blob, and that may point us toward the real sources," Jui said.
A preprint of the article may be found online at arXiv.org
More from SPACE.com:
Infographic: Cosmic Microwave Background: Big Bang Relic Explained
Twisted Physics: 7 Mind-Blowing Findings
The 9 Biggest Unsolved Mysteries in Physics
Copyright 2014 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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4.50 € incl. 19% VAT.
Info about this Item:
There´s no good fighting with an empty stomach...
The cooking fireplace is cast out of high-quality resin and comes unpainted. The figure shown on one picture serves as size comparison. The copyright for this figure is hold by the company "FreeBooter".
Base approx. 5 x 2,5 cm
Height approx. 6 cm
Thomas Doll


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tony stark
Agents of S.H.I.E.L.D.'s Comic Book Easter Eggs: Episode 2
The comic book Easter eggs in Agents of S.H.I.E.L.D. are fun -- but only if you catch them and know what they mean. Here's a...
How Iron Man 3 Flipped the Script on Female Characters
Want to see one of the most progressive portrayals of women in a blockbuster movie this year? Then go see Iron Man 3. As incongruous...
Exoskeletons, Lasers, and Jet Packs: How to Be a Real-Life Iron Man
Sure, so you'll never be able to fight alongside Thor or Captain America. That doesn't mean you couldn't try to be a real-life Iron Man...
Who's Who in Iron Man 3: The Arc Reactor Infographic
Keeping track of the characters in the Marvel cinematic universe can be daunting for all but the biggest fan. This awesome interactive infographic breaks it...
Tony Stark Summons a Squad of Iron Men in New Iron Man 3 Trailer
Tony Stark takes on his own demons and (presumably) the Mandarin in the latest trailer for Iron Man 3 -- this time with the help...
10 Second Iron Man 3 Tease Surprisingly Worth It
Marvel Studios has released a teaser for its upcoming Iron Man 3 Super Bowl spot. It's not much, but we'll take it.
Coolest Dude Ever Proposes to Girlfriend With Modded Iron Man Arc Reactor
When electronic-modding fan Eddie Zarick decided it was time to pop the question to his girlfriend Sarah Carter, he knew he wanted to do it...
Videos: Hulk Smashes, Team Assembles in New Avengers Clips
Director Joss Whedon has been saying he thinks his Bruce Banner/Hulk is going to be the thing Marvel Comics fans are most surprised by when...
New Avengers Trailer Builds Up Supergroup Drama
The hot new trailer for Joss Whedon's The Avengers is a virtual scruff-of-the-neck grabber, showing not only precious seconds of city-crushing war but also the...
Iron Man 2 Goes Viral with Stark Industries Website
Iron Man 2 is still several months away, but online promotion of the film is well under way with a new viral website for Stark...


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Tech Blog / Ghost writer
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I have ongoing SEO / Guest blogging work available. Looking for tech writers with a perfect grasp of written English and good research
skills. Must be able to write to tight deadlines. Should be able to contact blogs for guest posting. Initially we have some work available per month. Will be able to provide more in the future. An SEO expert to optimize my website for 10 keywords is a plus. Must be confident writing SEO articles, guest blogs and press releases.
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Migrate domain to Amazon and setup Amazon for Web Hosting
This project received 25 bids from talented freelancers with an average bid price of $126 AUD.Get free quotes for a project like this
Project Budget$30 - $250 AUD
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I have 2 domains on a VPS server.
I need to move the ENTIRE domains to an Amazon server for hosting.
They currently use cPanel / MySQL and are jQuery / PHP / HTML / CSS driven.
I need someone who has strong understanding of Amazon and can help and guide me to moving the domains with MINIMAL down time...
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Barry R. Masters
OSA Fellow Barry Masters recounts his ICO-sponsored visit to several world-class educational and research institutions in Shanghai.
Become a member or log in to view the full text of this article.
OSA Members get the full text of Optics & Photonics News, plus a variety of other member benefits.
Publish Date: 01 September 2008


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Exchange Rates in Search of Fundamental Variables
In this paper it is shown that relatively simple models are capable of generating exchange rate movements that, at least in the short run, are largely disconnected from their fundamental values. The essential ingredient of such models is the hypothesis that economic agents use different information sets. It is assumed that there are two classes of agents, fundamentalists and chartists. The former use the information contained in the model and a forecast of future fundamental variables. The latter forecast the future exchange rate based on past exchange rate movements. The interaction of these two classes of agents creates a non-linearity in the model and is responsible for the complex behaviour of the exchange rate.
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Originally posted on Red's Army | Last updated 10/23/11
Every morning, we compile the links of the day and dump them here... highlighting the big storyline. Because there's nothing quite as satisfying as a good morning dump. The new members of the staff - Mike Longabardi and Jamie Young - met with returnees Kevin Eastman and Armond Hill, along with head coach Doc Rivers for several hours earlier this month, and they plan to continue getting together until the lockout ends. The Celtics are not going to rest, according to Rivers, who said he is enjoying his time off but itching to return. "We work on our stuff, we work on our team,'' Rivers said. "We talk about the things we did well, the things we didn't do well last year, what we need to do this year to not lose to Miami. As a staff, you just work and get ready, and that's all you can do.'' ... Celtics guard Rajon Rondo has not organized a workout of his teammates but said he will look into it in the near future. Kevin Garnett was asked the same question a fe
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FAQs about Silicone Bakeware
FAQs about Silicone Bakeware from Overstock.com. Our guides provide customers with answers to frequently asked questions about silicone bakeware.
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I haven't used this loaf pan yet but I'm sure I will love it since I have other silicone baking pans and they are fabulous. Cupcakes, or whatever I'm making just falls out of the silicone pans and I don't use anything else anymore. The only problem is that after many uses they tend to accumulate some baked on stuff around the edges. You can remove it but it takes a lot of scrubbing. The benefit of these silicone pans FAR OUTWEIGHS that negative. My earlier pans had a textured surface around the edges which held onto baked on stuff and this one doesn't so it may look much nicer after frequent use. No matter, I love silicone pansRead More
Everything was as shown The color and size are goodRead More
I used it as a soap mold and made my soap loaf very wavy can not use the loafs for that purposeRead More
This item is nice if you're looking for standard size loaf pan. But if you're looking for wider and taller loaf pan you will be very disappointed. Because description shown the dimension are 9" long x 5" wide x 4" high. But real size only 9" long x 4-1/2" wide (3" at bottom) x 2-3/4" highRead More
Nice silicone loaf pan. Exceeded our expectations.Read More
I ordered two pans, one of them looks great, but the other one came warped and twisted and and bottom is not flat. I thought it was because of the way it was shipped (in an envelope and not in a box) but after a couple of weeks, it still looks as twisted and warped as the first day. I think it was defective. Silicone pans are really great, but they have to be in perfect condition to work properly.Read More
FAQs about Silicone Bakeware from Overstock.com. Our guides provide customers with answers to frequently asked questions about silicone bakeware.
Bakeware Tips for Every Kitchen from Overstock.com. Baking is one of the most satisfying kitchen activities, and the right bakeware can make the experience even better.
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Cheesecake Checklist from Overstock.com. Our guides provide customers with information about how to create and serve the perfect cheesecake.
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Hotel Corso B.V.
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TripAdvisor Reviews Hotel Corso B.V. Eindhoven
Travel Blogs from Eindhoven
... the Canadian Support Unit in Geilenkirchen. Dan and I served together in Kuala Lumpur, Malaysia back in the mid-90s.
Our next blog will feature some photos around their little town of Gilrath and of the Roach family.
Apparently we can even FT from their home so once I post this blog, I may try a quick FT with some folks.
Take care and by the way, they do have Indian summers in Europe too - amazing weather - high teens and going to 18C tomorrow. Stay warm!!!
Day 43 - Zonhoven to Oirschot
... a mile or so into the small, but perfectly formed Dutch town centre, dominated by a huge church. A pleasant interlude indeed. No cakes or ice creams, though both were available, but we found a hole-in-the-wall for some gelt, and sat outside to enjoy a couple of trappist beers, working up from seven to ten percent (hic) alcohol. Just an excuse, really, to also order some bitterballen. The bill came to €22 so we thought it was time ...
... it right here. We paid money for chips and the chips is what you use to buy food and drinks. It's so much more efficient. There are so many bathrooms I never waited in any line. The urinals are a different story. Imagine four urinals in a circular structure, OUTSIDE. Yea you just walk up in plain sight, unzip your pants and completely pee in public. That was crazy. There are bomb food stands everywhere and plenty of places to get drinks. We've only seen a handful ...
Tuesday Part 2
... br> The school of form- Poland http://www.sof.edu.pl/en/
Lidewij Edelkoort is one of the world's most famous trend forecasters. She travels the world studying the evolution of socio-cultural trends before sharing this information with her clients in industries as diverse as fashion, textiles, interiors, cars, cosmetics, retail and food. Lidewij's list of accomplishments are far longer then my arm.
In 2011, ...
Adventure racing, an energetic way to travel
... and stay completely dry. Photos of the day show four or five canoes capsizing whilst aiming for the upstream gates so our reluctance pays off! The most physically demanding part of the day is the canoe portage back to the club trailer...which seems to have been parked a lot further away than it could have been!
Stage six in a new one for us. We are given one "kick bike" which is basically a big scooter. Amanda jumps on and I run beside ...
Other places to stay in Eindhoven
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Four years ago, 7.5 percent of county voters went to the polls. By comparison, Tuesday's county primary turnout vote in Davidson County also is expected to be low.Only the Democrats are holding primaries there.
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That cost could have been $100,000 more had the Election Commission not reduced the number of poll workers and cut back on the number of voting machines hauled to election sites this year, as they again prepared for a low turnout. The March 2000 primary - which included the presidential primary and drew only 9.8 percent of registered voters - cost taxpayers $652,000, Pleasant said.Of that sum, about 70 percent was used to pay poll workers, with the remaining costs going for various expenses such as advertising, rent for polling locations and the transport of voting machines. "Political parties will tell you that local primary elections are worth it," said Pleasant."But from the point of view of what it costs, I don't think it is worth it." Local municipal elections are nonpartisan. Shelby County had a long tradition of nonpartisan elections, going back to the days when Republicans were an ineffective political force here.But 10 years ago, county GOP leaders decided to hold a primary for three posts - a judgeship, General Sessions Court clerk and Shelby County assessor.
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Operating System Roadmap through 2015
This project received 6 bids from talented freelancers with an average bid price of $ USD.Get free quotes for a project like this
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Project Description
Problem Statement: I am looking for a freelancer to create a powerpoint with all the upcoming OS, hypervisor, etc. listed below between 2012- 2015. I am trying to gather all of the roadmaps of these open source vendors in one view.
Here is the list of information that I would like to see:
OS: Fedora version and kernal updates), Ubuntu version and kernal updates, Windriver Linux version and kernal updates, Red Hat Enterprises Linux version and kernal updates
Hypervisor: KVM, VMware ESXi 5.0, Xen,
Complier: gcc, icc
Guardrails: I need this on one power point sheet which shows all of these elements in one view. I am trying to understand the trends of the hardware and what versions each of these versions of Linux depend on a specific kernal or release for the OS but for Hypervisors and compliers I would like to understand their next releases as well.
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Kicking Off NYFW with Chanel
Natasha Bedingfield and Rachel Roy share a moment at the exclusive dinner.
Tinsley Mortimer sports her signature braid and a strapless, beaded dress.
Olivia Palermo in sweet ruffles and layered bracelets.
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October 31, 2012 — This week on "Your Turn" , host Mike Causey is joined by one of the nation's top air traffic controllers.
Trish Gilbert is the executive vice president of the National Air Traffic Controllers Association.
She's part of a series we are working on to identify high-profile (and some not so high-profile) jobs in the federal government. Many members of the public know these people exist, but haven't a clue how they got where they are or what they do. So we're going to find out.
Sean Reilly of Fefrom the Federal Times will talk about the possible impact of the election on federal and postal workers, and retirees.
January retirement numbers fall short of dire, post-election predictions.
January retirement numbers fall short of dire, post-election predictions.
Photos of the amazing, moving, important and amusing things happening in the federal community.
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Welcome to The New ESU. Please bear with us as we upgrade the website.
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East Stroudsburg Normal School opened its doors on September 4, 1893. Today, ESU is a comprehensive university in northeastern Pennsylvania offering 56 undergraduate and 24 graduate degrees and is one of the 14 institutions in the Pennsylvania State System of Higher Education.
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Twitter Mailbag: Why you shouldn't eat turkey on Thanksgiving and other important tips
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NYPD Violated Rules In Its Continued Witch Hunt Against Muslim Groups
No consequences. What's a rule anyway?
Court Rules the NYPD's X-Ray Vans Can Remain a Secret
The NYPD must reveal potential health risks of the vans, but nothing else
Saudi Arabia Threatens Financial Retribution if U.S. Anti-Terrorism Bill Passes
"The president is siding with Saudi Arabia over the 9/11 families."
Harvard Study Refutes Claims That Encryption Will Prevent Terrorism Investigations
Researchers remind law enforcement how easy it is to keep track of anyone using the Internet.
President Obama: "We Cannot Turn Against One Another…"
"…by letting this fight be defined as a war between America and Islam."


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Cassini goodies: Telesto, Janus, Prometheus, Pandora, F ring
Posted by Emily Lakdawalla
As I mentioned yesterday, the Cassini raw images website has been full of goodies lately. Here's a sample.
(First, a quick update on the Station fire: Mount Wilson is still unscathed, and firefighters predict today will be a better day. Concern is abating.)
My favorite recent set of images was targeted at Janus. Take a look at this animation and see if you can figure out what's going on before you read any further:Did you figure it out? As the sequence starts, Janus is in eclipse -- it's in the shadow of Saturn's rings. But as Cassini watched, a gap in Saturn's rings crossed the moon, making a broad stripe of sunlight that moved from pole to pole. The gap appeared to have one sharp edge and one more transparent edge. I don't know which gap in the rings that was -- could have been the Keeler gap, maybe. I think I enjoy this animation especially because it's sort of like the evil alternate universe version of one of my favorite image series from the Voyager Saturn encounter: Recently Cassini also had a nice close look at Telesto, the trailing companion to Tethys. These Lagrangian moons look very very dusty; the Lagrange points of orbits must be a spot that collects Saturn's versions of dust bunnies. The image compliments nicely an earlier one of Telesto, which shows primarily the trailing hemisphere. Here's one more nice recent animation, showing the gores in the F ring created by Prometheus traveling around the ring ansa. Saturn is such a pretty place!
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The Vandalia Board of Education on Tuesday approved a 2-percent base salary increase for non-exempt district employees for the fiscal year starting July 1.
That raise applies to cooks, custodians, bus drivers, directors and administrators. It does not apply to teachers, who are still negotiating with district administrators on a new contract.
"The contract with the teachers' union is still pending," Superintendent Rich Well said after Tuesday's meeting.
"We met the last week in May, and we'll meet again in July."
Shortly after agreeing to talk to Mother of Dolors Catholic Church about increasing the maintenance fee for the city's Catholic Cemetery, Vandalia officials found out they didn't need to pursue the issue.
Alderman Neil Clark, chairman of the city's cemetery and landfill committee, reported at the June 6 city council meeting that the committee recommended talking to the church about increasing the $750 annual maintenance fee.
Thursday, June 23
✔ The Summer Lunches for Kids program is under way. The lunches are available from 11-11:30 a.m. at the American Legion Home and in Rogier Park in Vandalia, at the township building in Shobonier and at the township garage in Vera.
✔ TOPS IL 2490 will meet from 9:30-10:30 a.m. at First Baptist Church in Ramsey. Weigh-in is from 9-9:30 a.m. For more information, contact Dovie Heaton-Bergin at 283-1729.
The following marriage licenses have been issued by the office of Fayette County Clerk and Recorder Terri D. Braun:
William Scott McFarland
Sara Elizabeth Rees
John Thomas Hawthorne
Mary Rachael Renee Wilkerson
David Skylar Harrison
Danielle Jo Ann Crye
Jason Dominic Hoyle
Michele Rae Graumenz
Timothy Dean Donnals
• Anthony M. Hays, 19, 710 W. Main St., Ramsey, was arrested on June 21 on charges of reckless discharge of a firearm, aggravated unlawful discharge of a firearm, possession of drug paraphernalia and illegal consumption of alcohol. No bond amount was listed.
• Tammy R. Lewis, 40, 526 S. Seventh St., Vandalia, was arrested on June 20 for failure to appear in court on a charge of driving under the influence of alcohol. Bond was $3,000.
This week's Mystery Banks Photo: This picture, taken about 35 years ago, shows an uncle and his nephew.
15 Years Ago
1996 – Dr. Tom Jaselskis, a family practitioner in Vandalia for the past five years, announced that he was moving to Tennessee.
Matt Baker of Vandalia and Brian Maske of Ramsey earned degrees from the St. Louis College of Pharmacy.
Vernon and Alma Meyer of St. Peter were planning to celebrate their 50th anniversary.
Brooke Straub and Mandi Wasmuth of Vandalia were inducted into Phi Theta Kappa sorority at Kaskaskia College.
Twice within the past 30 days, I have found myself in the historic Old Liberty Cemetery in Sefton Township. Prior to that, I had never visited this historic burying ground, although I always thought that one day I would find the time.
Wilma Kruger of Brownstown was my first guide, and we were on an ancestor hunt. As we followed the road that led to the cemetery, she told me some of her memories of this area. One must cross both a bridge and a ford to reach the cemetery.
Local developer Dennis Grubaugh expressed his displeasure with a city official at last week's meeting of the Vandalia City Council. And, while we understand the need to address the issue raised by that city official, we also understand why Grubaugh was upset.
At two prior city council meetings, Alderman Dean Black said he didn't like the looks of the former State Farm Insurance building on Gallatin Street, referring to political signs covering the windows.
The city of Vandalia has retained Growth Services Inc., a workforce consultant, to conduct a survey of area employers.
The goal of the survey is to evaluate the area's workforce from the businesses' perspective.
The results will be used to identify and address workforce issues within the region and take steps to ensure that the needs of area employers are being met, both now and in the future.
Copyright © 2017
The Leader Union is your source for local news, sports, events and information in Vandalia, Il, and the surrounding area.


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[APP][2.1+] Omega Browser
Fast, smooth and easy to use, when you're browsing on a tablet or smartphone, Omega helps you get more out of your time online, whether you're finding information or relaxing with entertainment. It's the ideal web browser to use on fast network connections such as Wi-Fi, 3G and 4G. Its designed to make the most of your Android device.Supports Flash.Save battery and money.
1) Fast search in Google and voice search .
2) Fast page load.
3) Saving energy and money.
4) Full use of the screen.
5) Streamings audio and video players.
6) Search in address string.
7) Automatic completion of addresses.
8) Download manager.
9) Quick setup.
10)Support open local files.
11)Save page for view offline.
12)Autofill forms on popular sites.
13)Private mode.
On Google Play
- 03-16-2013, 04:12 AM Thread Author #2
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Re: [APP][2.1+] Omega Browser
1) Fixed crashes by intent.
2) Enhanced perfomance.
3) Fixed tabs size.
4) Minor changes.
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guy drains his main vein.4.18 / 5.00 7,244 Views
( Original ) Nesia Legend of Cosieda Episode 1
The first episode of my original anime3.96 / 5.00 2,581 Views
Godians Fight
Two Men Fight to the Death!4.15 / 5.00 2,055 Views
pretty good
the subtitles were really a pain to read but it was nice to see a sprite movie that was about lesser known characters.
Very interesting concept, but of course the subtitles can be improved a hell lot!, the surprised eyes are bummer though that is my opinion. Overall, quite a overall good animated flash
good animation
but please no more linkin park or any bands for that matter just go background music from old fightin games or something, It just seemed too emo to me. but that's just an opinion.
good sprite action
not to knock you, but you need to work on your english translations, other than that i liked it.
Yes, i really have to work on that ^^
It was alright.
Decent. But these types of movies are starting to get a bit stale.
Animation was smooth.
Sound started to get annoying after a while.
Music was meh. I don't recommend band music. Look through the audio portal, there are plenty of good music there to choose from.
Bottom line: Though a crossover movie is a good idea, some originality would be appreciated. Ever since Alvin-Earthworms SMB:Z series, these types of movies have gotten stale and its getting harder to look better.