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Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial
Recruitment status was: Recruiting
- Full Text View
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- No Study Results Posted
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- How to Read a Study Record
Large population-based studies suggest that patients with chronic obstructive pulmonary disease (COPD) are 2 to 3 times at risk for cardiovascular mortality, which accounts for a large proportion of the total number of deaths. How COPD increases the risk of poor cardiovascular outcomes is largely unknown. However, there is growing evidence that persistent low-grade systemic inflammation is present in COPD and that this may contribute to the pathogenesis of atherosclerosis and cardiovascular disease among COPD patients. Inflammation and more specifically, C-reactive protein (CRP), has been linked with all stages of atherosclerosis, including plaque genesis, rupture and subsequent thrombo-fibrosis of vulnerable vessels. Recently, our group has demonstrated in a relatively small study that short-term inhaled corticosteroid (ICS) therapy can repress serum CRP levels in stable COPD patients. Conversely, withdrawal of ICS leads to a marked increase in serum CRP levels. Although very promising, these data cannot be considered definitive because the study was small in size and scope (N=41 patients). Additionally, this study did not address the potential effects of combination therapy with ICS and long-acting β2 agonists (LABA). This is an important short-coming because combination therapy of ICS and LABA have been shown to produce improved clinical outcomes over ICS monotherapy and is commonly used by clinicians in the treatment of moderate to severe COPD. We hypothesize that inhaled fluticasone (Flovent®) reduces systemic inflammation and that combination therapy (Advair®) is more effective than steroids alone in reducing systemic inflammation in COPD. In this proposal, we will implement a randomized controlled trial to determine whether ICS by themselves or in combination with LABAs can:
- reduce CRP levels in stable COPD patients and
- reduce other pro-inflammatory cytokines, which have been linked with cardiovascular morbidity and mortality such as interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1)
Chronic Obstructive Pulmonary Disease
Drug: Advair
Drug: Flovent
Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
|Official Title:
|Advair - CRP Study
- Change in serum C-reactive protein levels over 3 months between treatment groups.
- changes in serum interleukin levels; quality of life; FEV1 between treatment groups
|Estimated Enrollment:
|Study Start Date:
|December 2004
|Estimated Study Completion Date:
|August 2006
|Ages Eligible for Study:
|45 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- All patients must have a clinical diagnosis of chronic obstructive pulmonary disease according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines.
- Patients must have a cigarette smoking history of more than 10 pack-years
- Patients must be clinically stable and at least 4 weeks from last acute exacerbation (and return to baseline level of symptoms)
- Patients must have an FEV1 of less than 80% of predicted values with FEV1 to FVC ratio of less than 0.70 (post-bronchodilator values)
- Men or women ≥ 45 years of age
Please refer to this study by its ClinicalTrials.gov identifier: NCT00120978
|Canada, Alberta
|University of Calgary
|Calgary, Alberta, Canada, T2V 1P9
|Links Clinic
|Edmonton, Alberta, Canada, T5G 3G6
|University of Alberta Hospital
|Edmonton, Alberta, Canada, T6G 2B7
|Grey Nuns Hospital
|Edmonton, Alberta, Canada, T6L 5X8
|Lethbridge Regional Hospital
|Lethbridge, Alberta, Canada, T1J 1W5
|Wetaskiwin Lung Laboratory
|Wetaskiwin, Alberta, Canada, T9A 3B8
|Canada, British Columbia
|Lion's Gate Hospital
|North Vancouver, British Columbia, Canada, V7L 2N3
|Vancouver General Hospital
|Vancouver, British Columbia, Canada, V5Z 3J5
|St. Paul' Hospital
|Vancouver, British Columbia, Canada, V6Z 1Y6
|Canada, Saskatchewan
|Royal University Hospita
|Saskatoon, Saskatchewan, Canada, S7N 0W8
|Principal Investigator:
|Don Sin, MD
|University of British Columbia
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|ClinicalTrials.gov Identifier:
|NCT00120978 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 11, 2005
|Last Updated:
|May 8, 2006
Keywords provided by University of British Columbia:
Clinical Trial; C-reactive protein; fluticasone; salmeterol
Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases
Fluticasone Propionate, Salmeterol Xinafoate Drug Combination
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Anti-Inflammatory Agents
Dermatologic Agents
Anti-Allergic Agents
ClinicalTrials.gov processed this record on February 20, 2017


text:
Re: Alexis DAOUST & Adeline CAMPEAU
In reply to:
Alexis DAOUST & Adeline CAMPEAU
Bud Lemire 7/02/00
Dear Bud,
I have an Angelic D'Aoust (Daoust-Daust-Dault) who was married to Jacques Duncan Fauvel (Fovell-Fovelle-Fauvelle) January 7, 1845 in St. Polycarpe Quebec. They moved to Saginaw, MI. I have the listing of all of there children and their descendants.
Angelic's brother, Antoine, married Domithilde Fauvel on October 15, 1850 in St. Polycarpe, Quebec.
Angelic and Antoine were children of Guillaume and Victoire Heneau (My great great great grandparents. Angelic was my great great grandmother.

subset: commoncrawl


text:
Samlesbury Hall
Preston New Road, Samlesbury, Preston, PR5 0UP
01254 812010
Adult £5.00 Child £3.00
Sun, 11am - 4.00pm, Free Parking
All ages
The Grounds and Hall play host to a superb day of family fun, entertainment, countryside displays and amazing activities.
The day includes our courtyard food and craft stalls, live music, Cuerden Birds of Prey, Punch & Judy show, Merlin magic and new for 2013 is Zoo 2 You this is a great interactive display of animals and includes Meerkats, & Snakes!
There are also Donkey rides & face painting at an extra charge.
There will be a wild life walk from the Wildlife trust around the grounds & Guided Tours inside the Hall.
We have Food available from our Restaurant or the BBQ and NEW for 2013 our Ice Cream Parlour will be serving the great MOO2YOU ice cream!
Times and prices are subject to change. Contact venue before setting out.
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Link Building / Social Media / Wordpress VA
- Status Completed
- Budget $30 - $250 USD
- Total Bids 8
Project Description
Social Media/Link-building Virtual Assistant
I'm looking for a trustworthy individual who can communicate clearly and always pays close attention to the details. The ideal candidate's nationality or ethnicity is not important though excellent spoken and written English is essential.
The ideal candidate should also have extensive experience and involvement (1 year or more) in running internet marketing campaigns, in particular in performing directory submission and link-building, promoting content via social media (social networks, social bookmarking) and using Wordpress. A strong working knowledge of HTML & CSS is also required and graphic design skills would be a huge bonus.
Tasks Include:
• Data Entry
• Directory submissions
• Add posting
• Link-building
• Bookmarking pages using multiple networks
• Posting links and content on social media accounts
• Adding content to document sharing sites
• Adding content to Wordpress blogs
• Setting up online accounts, e.g. email addresses, social media accounts, etc.
Candidate must:
• Have a strong, trustworthy character
• Be hardworking and reliable with good attention to detail
• Be a good communicator and take instruction well
• Have excellent English skills and a global outlook
• Have a strong working knowledge of HTML and CSS
• Have experience using Wordpress
• Have overall skills and experience in internet marketing
*Bonus Skills and Experience:
• Graphic design skills
• Video creation skills
• Copywriting and Content marketing experience
• Experience using Market Samurai
• Experience using Hootsuite
When applying for this job please provide thorough details of your skillsets and previous experience, along with a brief outline of the software packages you are proficient in, and development languages, if any.
Please also include any materials which you consider relevant – qualifications, references, resumes, portfolio items, and so forth – as well as personal details, payment details, location, timezone and hours of availability.Get free quotes for a project like this
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- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
asperger syndrome Stories
Differences In The Frontal Lobe Mark The Autism BrainAdult men with autism spectrum disorder show subtle differences in the white matter found within their frontal lobes compared to unaffected men.
With Autism, Girls Need Special AttentionGirls are diagnosed with autism later than boys, possibly due to the fact that symptoms appear less severe in girls.
Autistic Patient's Amygdala, Brain's Face Recognition Region, Activates Different NeuronsResearchers found that the amygdala, the region of the brain connected to emotion and face recognition, activates different neurons in autistic patients, who generally focus more on the mouth than the eyes.
UK Man Drinks Himself To Death... With SodaA medical inquest into the death of a man named Paul Inman has concluded that his habit of drinking three liters of soda caused his lungs to overswell.
DSM Revision Removes Asperger Syndrome, No Longer Classifies Transgender as DisorderThe changes to the Diagnostic and Statistical Manual, the closest thing to a manual for those in the psychiatric and psychological professions, are in.


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Endapest Services is a locally owned and operated business providing professional pest management services. We have over 38 years of ..
Mudgee Pest Service provide effective solutions to take care of those unwanted pest problems. Your Local Pest Management Professionals..
Cudgegong Honey can help with all things bee. From honey to hives and even wax. I collect swarms and remove any pest wild hives that m..
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Our consultant was on time, efficient and honest. The job was booked within the hour and completed within the week. Very happy with the level of professionalism and friendliness.
Should have taken note of previous review about arriving early. Very pleasant and professional and is willing to follow up if the need arises. I would definitely recommend Central Coast Pest Services.
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G.B.H. Slit Your Own Throat ? Lyrics
Last updated: 04/16/2003 05:22:35 AM
Exempt from the laws which you created,
your thought out lies becoming dated.
Ruin our lives then plead for support,
the noose around your neck is getting taught.
Slit your own throat.
Your ignorance is hard to believe,
do you want this country to bleed ?
Stuck in a rut full of rot,
complain about things you haven't got.
Disrupt the lives of those around,
it's time you lot were underground.
But no-one hears when you start to moan,
sulk in self-pity 'till the cows come home.


text:
- Doctors
- Alberta
- Calgary
- Orthodontists
- Dr. Michael French
You may also like
Dr. Cory Liss
Ratings for Dr. Michael French
Dr French was recommended to us by friends who research EVERYTHING and I am so happy that we went to him. Both of my daughters have beautiful smiles and both of them had 2 phases to complete. Between the 2 of them (who went through treatment at the same time) I felt like I was at his office every couple of weeks. Dr French was wonderful in every way. One of my daughters has panic anxiety disorder and I really worried whether or not she would allow him to even start treatment. She was absolutely fine, he made her laugh, was so sweet and caring and both of my daughters loved him. I would highly recommend him (and have) and I have gotten great feedback from friends the have gone to Dr French.
We have dealt with Dr. French for 8 years while both of our children had their braces. We have always had good experiences with both him, his business partner, Dr. Olsen and their staff. Everyone working at Authentic Orthodontics are friendly and seem to enjoy their jobs. We have never been kept waiting past our appt. times as they run an very efficient office. When my husband lost his job, Dr. French waited patiently for us to get back on our feet financially while still treating our children. I would highly recommend Dr. French and his team to anyone!
Terrible experience would never go back, painful and my teeth have shifted.
Awesome doctor and awesome staff! As an adult I had braces from Dr. French and my daughter is currently being treated. I am a highly skeptical patient and I am sure that if he could rate me, I would rate low. He is patient, knowledgable, cautious and funny!! Our family loves Dr. French!!
Our oldest daughter has a perfect smile thanks to Dr. French and we are now back with our youngest and wouldn't consider going anywhere else. Dr. French takes the time to explain all of the options available to obtain the best outcome while being aware that not everyone has orthodontic coverage or an unlimited budget.
Dr French is an excellent orthodontist... Nothing flashy about this man at all. Very down to earth and incredibly friendly. He is very knowledgeable and not pushy with his treatment. I like his conservative approach. Highly recommend this office. Staff is awesome too... After all he couldn't do his job without those amazing ladies.
Dr. French is a very wonderful orthodontist with lots of experience and knowledge and I love his new office! His staff are also all very friendly and welcoming.
An excellent Orthodontist. Would recommend him to anyone. Very personable and knows his stuff. My daughter's smile is perfect now and I am about to get out of adult braces myself. We will continue to drive across the city for our other children to see this excellent Orthodontist. Very friendly, very good care.
Dr FRENCH in my opinion is one of the best Orthodontists in Calgary, after taking advice from another orthodontist in Calgary who told me my daughter would not need Phase 1 treatment I waited and at her dental check up her regular dentist told me that she has a issue with spacing and not enough room for her adult teeth to come in. I went back to the same orthodontist and basically he said my general dentist was over reacting.I decided to find another orthodontist and I found DR FRENCH I trusted his opinion 100% and we got started right away we have completed phase one and well into phase II treatment. All orthodontists out there have different opionions, phase one treatment from my research is very beneficially and with Dr. French completing phase I treatment her need for extractions was eliminated. The first orthodontist wanted to take out 4 teeth which was a quick fix in my opinion. Dr. FRENCH did it the right way.i'm one happy mother who knows my daughter will have amazing smile..
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The NGO, Amnesty International, has raised allegations that Israel committed war crimes in Gaza, including attacks on hospitals and medical staff, which are supposedly based on the testimonies of Gaza Strip residents.
A statement issued by the organization called for an immediate investigation of what it called "mounting evidence that the IDF opened deliberate attacks on civilian targets in the Gaza Strip".
Tags:Hamas, IDF, Gaza Region, Amnesty International


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Uwe Schindler (JIRA)" <j...@apache.org>
|[jira] Updated: (LUCENE-2333) Failures during contrib builds, when classes in core were changed without ant clean
|Fri, 19 Mar 2010 10:33:27 GMT
[ https://issues.apache.org/jira/browse/LUCENE-2333?page=com.atlassian.jira.plugin.system.issuetabpanels:all-tabpanel ] Uwe Schindler updated LUCENE-2333: ---------------------------------- Attachment: shai-compile-fix2.patch shai-compile-fix.patch Here 2 patches: *The first one only changes the following:* It now does not do any "short-circuit" checks for the core.jar available, instead solely uses a property that is set by the parent. This works good, now always when you compile a contrib solely (inside its folder), the core is compiled. If you run from top-level build.xml the top-level build compiles the core as dependency and passes the "core.compiled" property down to the contrib-crawl. In contrib are still other short-circuits like this. E.g. The benchmark contrib checks, if the jar files of other contribs it depends on are available and only if not recompiles. This leads to the same problem is you change one of the depends-on contribs source code. In this case there is no way around a top-level clean, sorry. *The second patch improves more:* It removes the dependency to build the jar file of lucene, it simply uses the classes/java folder. It needed some more refactoring, to get rid of the ${lucene.jar} property. In contrib-build.xml now a separate base.classpath ref is defined that can be used everywhere to extend the default classpath, also set by contrib-build.xml. The patch also contains a refactoring of contrib-ant, to use a resources-folder like other contribs. To get contrib-ant jar file compile correctly, do the folldoing svn commands inside contrib/ant: {noformat} svn mkdir src/resources/org/apache/lucene/ant/ svn move src/java/org/apache/lucene/ant/antlib.xml \ src/resources/org/apache/lucene/ant/antlib.xml {noformat} > Failures during contrib builds, when classes in core were changed without ant clean > ----------------------------------------------------------------------------------- > > Key: LUCENE-2333 > URL: https://issues.apache.org/jira/browse/LUCENE-2333 > Project: Lucene - Java > Issue Type: Bug > Components: Build > Reporter: Uwe Schindler > Assignee: Uwe Schindler > Fix For: 3.1 > > Attachments: shai-compile-fix.patch, shai-compile-fix2.patch > > > From java-dev by Shai Erera: > {quote} > I've noticed that sometimes, after I run test-core and test-contrib, and then change core code, test-contrib fail on NoSuchMethodError and stuff like that. I've noticed that core.jar exists under build, and I assumed it's used by test-contrib, and probably is not recreated after core code has changed. > I verified it when looking in contrib-build.xml, which defines a property lucene.jar.present which is set to true if the jar is ... well, present. Which I believe is the reason for these failures. I've been thinking how to resolve that, and I can think of two ways: > (1) have test-core always delete that file, but that has two issues: > (1.1) It's redundant if the code hasn't changed. > (1.2) It forces you to either jar-core or test-core before you test-contrib, if you want to make sure you run w/ the latest jar. > or > (2) have test-contrib always call jar-core, which will first delete the file and then re-create it by compiling first. Compiling should not do anything if the code hasn't changed. So the only waste would be to create the .jar, but I think that's quite fast? > Does anyone, with more Ant skills than me, know of a better way to detect from test-contrib that core code has changed and only then rebuild the jar? > {quote} -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online. --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: email@example.com
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Welcome Aboard!
Palmer's Cove Yacht Club is located in historic Salem Harbor, Massachusetts. We are an active group of New England boaters, sailors, and fishermen who appreciate the unique natural features and challenges of our beautiful coastline. Our members enjoy a year-round program of banquets and parties, tournaments, visitations and family events.
Check our updated 2017 calendar for important dates and events:
2017 Calendar page
PCYC Bylaws
Updated March 2015. Click HERE for a PDF file. For security reasons a password is required; contact Secretary if you don't know it.


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K.atou brings her stripped-down techno to NORAD on September 8
K.atou is one of the hometown heroes of Athens, Greece. Not long after she was honing her needles as a teenager at Bossa Nostra, one of the city's biggest clubs, she was going to college in the United Kingdom, where she managed to expand her musical education while still keeping her fan base in Greece fed with appearances. Eventually, the only town big enough to hold K.atou comfortably was Berlin, so that's where she resides these days, jetting off to perform all over the globe. She might start a set with mechanical, stripped-down techno and wrap it up immersed in deep, soulful house, but in between, an underlying minimalist foundation remains beneath each track, tying them all together in a seamless whole. The result is twitchy, dynamic, upbeat music that makes it utterly impossible for toes, heads and other body parts to stay motionless. K.atou will make her Denver debut along with nu-disco-house heavyweight Slow Hands at an all-night after-hours event on Saturday, September 8. Visit facebook.com/events/256019937835040 to get in the loop.
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Keep your thumb on the local music scene each week with music news, trends, artist interviews and concert listings. We'll also send you special ticket offers and music deals.
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TicketsThu., Feb. 23, 8:00pm
Chancey Williams & the Younger Brothers
TicketsFri., Feb. 24, 8:00pm
Eldren's Dark Side of the Moon, Bowie and Beatles Tribute
TicketsFri., Feb. 24, 8:00pm
Stewart Copeland & The Colorado Symphony
TicketsSat., Feb. 25, 7:30pmpowered by goldstar
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10 Traits Of A Passionate Particular person
After 30 years taking part in with younger youngsters as an Early Childhood Educator I'm on a mission to remind 'grumps' to loosen up and PLAY their technique to success... nonetheless they outline success! I am a business growth knowledgeable aka coach (not licensed) with an MBA in advertising, 35 years of gross sales and advertising expertise in many startups in three nations together with 10 of my very own, 2 quite successful B2B & B2C together with getting to 20 staff and 7-figures. I was bowled over in that this man held a place of authority in these children's lives as a coach, a instructor and as a mentor. So having good coping skills is vital for us to have a thriving and successful life.
What one can sick afford to refuse to just accept is the significance of skilled teaching whenever you want it most. An aerial view of the site where a coach carrying members of an aged individuals's club collided with a truck (hidden by timber) outside Puisseguin near Bordeaux, western France, October 23, 2015. But the distinction is that you just're not advertising and marketing to enterprise homeowners saying you are a advertising and marketing professional!
We keep our class size very small, so that we are able to provide extra one-on-one training and cover all points of life teaching. Our life coaching program was written by the creator of the Be Completely happy in LIFE Program, Ronit Baras, who's an knowledgeable in emotional intelligence and has 25 years of expertise. That stated, it is not possible to know what one's expertise will likely be earlier than entering any coaching program.
It may be that many of the survey respondents see little connection between formal coaching as a psychologist and enterprise insight—which, in my expertise as a coach of coaches, is an important think about profitable coaching. At the similar time, the coach you might be interviewing can be interviewing you because it is always in everyone's best interest for the fit/match to be mutual.
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GBC Frost 14mil 8.75" x11.25" Poly Covers (25pk) - 2514501
These unpunched 14mil 8.75" x 11.25" frost poly covers from GBC are durable, spill-proof, and tear-proof. Additionally, these oversize translucent frost covers will show off your title pages and provide a premium look to your reports and presentations. GBC's oversize frost covers are perfect for use with any binding style (see list below). With more than 200 other frost covers to choose from, you're sure to find the exact cover for your needs. This unpunched 14mil 8.75" x 11.25" cover's product number is 2514501 and comes in packs of 25.
Product Details
- Cover Type: GBC Frost Poly
- Cover Thickness: 14pt
- Cover Size: 8.75" x 11.25" (Oversize)
- Color: Translucent Frost
- Corners: Round
- Quantity: 25 Pieces
- Part Number: 2514501, G2514501
- Primary UPC: 033816041509
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VeloBind (11 Hole Round)
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text:
Leading Housewares Innovation Since 1851
While Taylor traces its history back to 1851, Rob Kay and the private equity firm Centre Partners teamed up in the Summer of 2012 to acquire Taylor Precision Products as a platform from which to create a global leader in the housewares industry. At the time, Taylor was focused exclusively on scale and measurement products, and with commanding market positions in these categories, the company had pervasive distribution across all classes of trade. Rob's vision was to build upon this infrastructure and become a full spectrum provider of houseware products selling into these same channels, and thereby offering a greater value proposition to its customers and the consumer.
Our Business Model is Centered On:
- Best-in-class design and engineering
- Substantial, talented in-house product development function
- Leader in innovation and champion of stylish, relevant products that meet consumers needs
- Highly efficient, low cost supply chain capability
- Global ability to bring products to market
- Value-added conduit for external inventors and smaller product developers to commercialize, win, and retain sales distribution
- Focus on brand building and direct-to-consumer marketing
- Industry leading online marketing and commerce capabilities
- Proven capability for developing both trade and direct to consumer marketing programs to build sustainable brands and product categories
Timeline of Taylor Acquisitions
At Taylor, we support the communities where we live and work. We've held food drives, planted vegetable gardens, coordinated holiday gift giving programs, and fundraised for charity walks and runs. We're always looking for more opportunities to serve – for production donation requests or community service opportunities, please reach out to us at firstname.lastname@example.com.


text:
2016-17 MESA Day Competition Rules
The rules for these events are grade-specific and reinforce California State Board of Education math and science standards. Special thanks go to the MESA Day Committee members—teachers and MESA directors—who worked diligently on this project. If you have any questions about these competitions, please contact your MESA Advisor or local MESA Center Director.
Process (pdf) and Form (pdf)
Process (pdf) and Form (pdf)
Code of Behavior
Code of Behavior (pdf)
Middle School Competitions | Grades 6-8
National Engineering Design Challenge – Prosthetic Arm
Prosthetic Arm Resource Document
2016-2017 SparkFun Kit Price Breakdown
Mousetrap Car
Stick Together
Model Science – GI Physiology
Balsawood Glider
Speak Up
Solo Math (8)
Team Math Quest (6-7)
Rube Goldberg – PILOT
Wright Stuff Glider – PILOT
High School Competitions | Grades 9-12
National Engineering Design Challenge – Prosthetic Arm
Prosthetic Arm Resource Document
2016-2017 SparkFun Ket Price Breakdown
Mousetrap Car
Civil Structures
Model Science – Heart
Balsawood Airplane
Speak Out
Solo Math (9-11)
Team Math Quest (12)
Rube Goldberg – PILOT
JPL Wright Turn Glider – PILOT


text:
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Lot 4163: Matchbox Scale Model Rag and Bone Merchants Cart
General Toy Sale to include Sci-Fi, Robots & TV Related
by Vectis Auctions Ltd
October 26, 2016
Stockton on Tees, United KingdomLive Auction
Looking for the realized and estimated price?
Description: Matchbox Scale Model Rag and Bone Merchants Cart - yellow body, red wheels complete with figure driver and load of 7 x pieces, grey horse - this is a reissue No.403 of 500. Near Mint, small loss of paint to driver in Good Plus box.
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$1,000 to Spend Toward Lasik Eye Surgery
Mobile / Baldwin County$1,000$100
$40 to Spend at Lens.com
Mobile / Baldwin County$40$20.99
D'Olive Bay Chiropractic
Initial Exam, X-Rays, First Adjustment + Massage
deal over
deal over!
100% recommendedin LivingSocial customer ratings
Happily helping his Daphne clients feel ahh-mazing, Dr. Steven Wetzonis prides himself on offering unparalleled customer care. Give your back some much-needed TLC with this offer:
• $50 ($290 value) for an initial exam, X-rays, first adjustment, and a one-hour massage
• $30 ($230 value) for an initial exam, X-rays, and first adjustment
• $30 ($60 value) for a one-hour massage
D'Olive Bay Chiropractic's Website
PAID VALUE EXPIRES ON February 27, 2022
PROMOTIONAL VALUE EXPIRES ON November 2, 2014


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The NEA Jazz Master is joined by host Danny Glover and an all-star ensemble of Dizzy Gillespie alumni, including other NEA Jazz Masters Slide Hampton, Jimmy Heath, and Paquito D'Rivera.
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All events and artists subject to change without prior notice.
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CRCfm is a community radio station licenced by the Broadcasting Authority of Ireland to broadcast 24 hours per day to the 30,000 people who live in and around Castlebar, Co Mayo in Ireland. Our brand of radio is different to any other in this area.
Radioline gives to users access to more than 60.000 News, Sports, Talk, Music radio stations and podcasts worldwide. The user can easily find and listen to his favorite radio stations, and discover new ones according to his mood, location, musical taste and more!


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Take our items that are listed on Amazon and add them to Volusion - repost
- Status Closed
- Budget N/A
- Total Bids 18
Project Description
We currently have approximately 1,000 items that we have listed on Amazon and Amazon webstore. We are now working on moving our Amazon webstore to Volusion. This person will take these 1,000 items and create them on Volusion. Most items are clothing and require the setup of a Parent - Child relationship. You will need to create Volusion options for all the items which will include sizes and colors. For the parent SKUs, you will need to write product descriptions, copy/paste size charts, upload images and fill in approximately 15 fields. Approximately 50% of the data can be downloaded from Amazon and reused in Volusion. I am looking for someone with EXCELLENT database skills and Volusion skills for this assignment. You can see our current web site at www.storecloset.com.Get free quotes for a project like this
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WordpressPayPal Advance with pluginORwithout
This project received 12 bids from talented freelancers with an average bid price of $91 USD.Get free quotes for a project like this
Project BudgetN/A
Total Bids12
Project Description
Please have a look at the [url removed, login to view] file attached to this so that I may know that you have read it and understood what to do. This will filter me from those who is just biding blindly.
Please start you bid with the word or mention the word "Advance".
Payment, I will make the milestone once you have started the project and you show me a demo through Teamviewer that its done and I will make the full milestone and you give me the work done and I will release the payment. Please have a look at my reviews I am always loyal to my freelancers.
You also should be available for further support or any bugs or more customization or long term technical partner which will be different project/s.
Looking forward to work with you. Thank you.
Skills Required
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text: Def Jam Recordings co-founder Russell Simmons and his ex-wife and business partner, Kimora Lee Simmons, are the parents of two girls, 14-year-old Ming and 11-year-old Aoki. When the couple divorced, in 2009, they made a conscious decision to stay close friends and put their daughters' interests first. Watch as Russell shares one of the most powerful lessons his girls have taught him.


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The acclaimed ensemble of NSO musicians plays Shostakovich's Sonata for Viola and Piano, plus Dvorák's Piano Quintet in A major.
The Fortas Chamber Music Concerts are supported by generous contributors to the
Abe Fortas Memorial Fund, and by a major gift to the fund
from the late Carolyn E. Agger, widow of Abe Fortas.
Please use the event calendar to search for current events.
All events and artists subject to change without prior notice.
All ticket prices are subject to change based on demand. Purchase early to lock in prices and the best seats!


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International water transfer and sharing: the case of the Ganges River
The following paper is concerned with water sharing of the Ganges River between India and Bangladesh, with possible augmentation through water transfers from Nepal. We analyzed the case when water from Nepal can be transferred to Bangladesh through the upstream country, India, as the local geography only permits such water transfer. A game theoretic model is formulated to determine the optimal share of water diverted to Bangladesh by India, and the optimal amount of water transfer from Nepal. India may gain positive externalities from such water transfer. The positive externalities generated from water transfer from Nepal may influence the water share of both India and Bangladesh. In the absence of altruism, India would allow less water flow to Bangladesh than in the case when there is no provision to buy water from Nepal. We also explored whether positive externalities could induce India to buy water jointly with Bangladesh, and such a case will only occur if the countries possess altruistic concerns and share water according to an agreement.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
Volume (Year): 13 (2008)
Issue (Month): 01 (February)
Pages: 29-51
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| Postal: Cambridge University Press, UPH, Shaftesbury Road, Cambridge CB2 8BS UK
Web page: http://journals.cambridge.org/jid_EDE
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Religion & Spirituality, Christianity, Society & Culture, HistoryFollow
|Religion & Spirituality
Pastor Mark Driscoll is a Jesus-following, mission-leading, church-serving, people-loving, Bible-preaching pastor. He's grateful to be a nobody trying to tell everybody about Somebody. This channel features audio content from Mark Driscoll, including sermons and event teaching. Mark preaches about Jesus with a skillful mix of bold presentation, accessible teaching, and compassion for those who are hurting the most. For more great teaching resources visit markdriscoll.org
June 1st, 2014
Episode 81 of 265 episodes
Pastor Mark Driscoll sits down with Matt Chandler and Crawford Loritts in these Q&A sessions recorded live at the 2013 Resurgence Conference in Seattle, WA.
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Welcome to the daily audio workout for your head.


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Angelina Jolie in Turkey Pictures
Angelina Jolie Welcomed as "Goodness Angel of the World" by Refugees in Turkey
Angelina Jolie got quite the warm reception as she arrived in Turkey today to visit with Syrian refugees. An enormous banner calling her "goodness angel of the world" was strung up to mark her arrival — check out a picture of it in the gallery. Angelina is overseas with the rest of the Jolie-Pitts while Brad gets to work filming World War Z in nearby Malta, so she took the quick trip as part of her work with the UNHCR. The Jolie-Pitts are setting up camp in Malta, which meant Angelina took the kids to a toy store to pick up goodies for the reported $11 million mansion they're renting.


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- Research Department Plasmas with Complex Interactions
- Center for Plasma Science and Technology (CPST)
- SFB/TR 87: Gepulste Hochleistungsplasmen zur Synthese nanostrukturierter Funktionsschichten
- FOR 1048: Instabilities, Turbulence and Transport in Cosmic Magnetic Fields
- FOR 1123: Physics of Microplasmas
Plasma Science - From Microelectronics down to Medical Engineering
It is still possible to make great scientific discoveries. In the 21st century they are mainly confined to certain research areas. And plasma science is definitely one of them. Experts agree that plasma technology will initiate fundamental innovations in microelectronics, surface treatment and medical technology.
Plasma science has a long tradition at the Ruhr-Universität. For three decades plasma science and plasma technology have been a main research interest here and since 2002 the interdisciplinary "Center for Plasma Science and Technology (CPST)" has taken over their coordination. Core research activities include plasma generation, plasma diagnostics as well as model development and surface interaction. The CPST has specialised in low temperature plasmas and cooperates closely with industrial partners in this field.
New focal point: microplasmas
In cooperation with the Heinrich-Heine-University Düsseldorf and the Research Centre Jülich the Ruhr-Universität operates the Virtual Institute "ITER – Relevant Plasma Boundary Physics" of the Helmholtz Association. Currently, a new focus in plasma science is being developed in Bochum: It aims at the generation of microplasmas at atmospheric pressure and opens up a broad spectrum of novel applications from biomedical sciences to nanotechnology.
At present approximately 200 natural scientists and engineers at the RUB carry out plasma research – in the CPST, in the Collaborative Research Centre Transregio "Pulsed high power plasmas for the synthesis of nanostructural functional layers" or in the Research Unit 1048 "Instabilities, turbulence and transport in cosmic magnetic fields" and 1123 "Physics of Microplasmas".
SFB TR and CPST are also partners in a new international association of worldwide leading institutions in plasma science and technology, including partners in Japan, France, Ireland, Korea and the Netherlands; the only two German members are the CPST and the Institute of Low Temperature Plasma Physics Greifswald (INP), member of the Leibniz Association.
All the structures combine their activities in the Research Department "Plasmas with Complex Interactions".


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Are you looking for weekends away in West Yorkshire? Hotfrog showcases more than 6 popular businesses related to weekends away in West Yorkshire! Find a specific region or suburb using the left navigation.
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4kits.co.uk - Essentials For The Outdoors, Travel and Leisure. 4kits.co.uk sells leisure survival kits for various activities - winter sports, gap …
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Choose from British, European and Worldwide location and accommodation choices, ranging from friendly, family run hotels to four star luxury. From scenic coach tours, themed breaks, traditional Christmas holidays, flight…
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Receive the latest in Footwear, Fashion, Music and Creativity in our newsletters.
While Bob Marley's classic and universally likable music has stood the test of time since his death in 1981, his family and others close to him have seldom opened up about his personal influence as a father or the atmosphere in Jamaica during his ascent to global fame. Now, Academy Award-winning director Kevin Macdonald wishes to tell this rarely illuminated story with Marley, which is set to premiere at the Berlin Film Festival and SXSW in March. It will be appearing in theaters as well as video-on-demand on April 20.


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Looking to move to tennesee
I'm not sure what I'm in for but what are jobs colleges Jeepin areas and living like around Nashville and such? I have auto collision training and I would be kinda interested in trying to run skid loaders and such. Anyone got sum advice for a fellow jeeper looking for a better living?
Wheeling...north of nash is Land Between the Lakes Federal Recreation Area witha dedicated area for ORV's..15.00 for three days or 60.00 for a year. ABout an hour north is Bowling Green, KY and they ave a private ORV park called the Wishbone..very good wheeling there. South of the city about an hour is another private park called Wooly's and that is a good place as well. East TN has several places and they are two to four hours away.
Hope this was informative and welcome to the area.
It is quite helpful any good job search sites. Or local newspaper websites that could list jobs and such to help me out? Google isn't very specific in job searches.
One of the bigger construction companies in the nash area is Hardaway Construction Inc. Check on the Hemlock Semi-Conductor web site. Some of the smaller companies use the TN Employment Centers. Logging was fairly big until a few years ago. Sorry can't help on the logging companies.
Well I tried those two things and got nothing. Thanks for your help sir. If anybody has any other ideas let me know
Skid Steer Operator Jobs, Employment in Nashville, TN | Indeed.com
Express Employment Professionals
Found these two....they are fairly old (8 days) but maybe you;ll get lucky...lol
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Journal of Basic and Clinical Physiology and Pharmacology
Editor-in-Chief: Horowitz, Michal
Editorial Board Member: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu
SCImago Journal Rank (SJR) 2015: 0.302
Source Normalized Impact per Paper (SNIP) 2015: 0.474
Impact per Publication (IPP) 2015: 0.759
- Online
- 2191-0286
Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats
1Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Oyo State, Nigeria
2Faculty of Veterinary Medicine, Department of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria
Citation Information: Journal of Basic and Clinical Physiology and Pharmacology. Volume 24, Issue 4, Pages 307–312, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2012-0061, March 2013
Publication History
- Received:
- 2012-10-10
- Accepted:
- 2013-02-24
- Published Online:
- 2013-03-18
Background: This study was conducted to investigate toxicological effects associated with prolonged consumption of Moringa oleifera leaves as a beverage.
Methods: Thirty rats were used in this study. They were grouped into five groups of six rats. Rats in group I received 2 mL/kg body weight (b.w.) of corn oil (vehicle). Animals in groups II, III, IV and V received 50, 100, 200 and 400 mg/kg b.w. of methanolic extract of M. oleifera (MEMO) for 8 weeks. Serum collected was analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, blood urea nitrogen (BUN) and creatinine.
Results: There was a significant (p<0.05) increase in serum total protein and globulin in a dose-dependent manner. Rats that received MEMO at 200 and 400 mg/kg b.w. showed a significant (p<0.05) increase in serum ALT, AST, BUN and creatinine which pointed to hepatic and kidney damage. All experimental animals that received MEMO had a significant (p<0.05) increase in body weight in a dose-dependent manner.
Conclusions: This study therefore confirms for the first time that chronic administration of M. oleifera leaves might predispose to hepatic and kidney damage.
Keywords: kidney; liver; Moringa oleifera; toxicity assessment
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The Role of Cognitive Data Management in Active Archive ArchitecturesSubmitted by admin on Wed, 12/21/2016 - 08:17
By David Cerf
Today's storage environments are comprised of a complex mix of file and object storage, and various file systems each with their unique behaviors. Due to the dependencies between clients and storage resources, users can find it difficult to deploy an active archive for migrating or tiering to cost effective storage. Complex file storage infrastructure can result in low utilization and limit data mobility. The continued growth in unstructured data (files & objects) is increasing the complexity, costs, and operational overhead for data management.
How metadata is changing active archives
Embedded in every file is a treasure that can be used to improve data management and power an active archive, it is metadata. Metadata may be just a simple description of a file but it has very relevant information about the data. When combined with other metadata, policy engines and artificial intelligence, metadata becomes an incredibly valuable source of hidden information that can be used to drive data lifecycle management, improve workflow and enhance applications. Most importantly, this metadata can drive an active archive architecture, using metadata as the trigger to enable data defined tiering and data protection.
Data management is now "cognitive"
Most of today's file-based workflows have no way of discovering or making use of this information in a simple to use, automated manner. But new cognitive data management solutions with their policy engines, are designed to complement any existing storage environment and enable an automated active archive. This means any file system can now add tape and object storage easily, improving data preservation and retention, search and collaboration, resulting in evergreen storage strategies for simplified migrations and tiering.
2017 Data Storage and Active Archive PredictionsSubmitted by admin on Tue, 11/29/2016 - 22:08
Over the past year, new storage technology innovations for active archives have enabled organizations to gain reliable access to all of their data, all of the time. As a result, these organizations have experienced increased cost savings, decreased energy consumption and improved storage administrator efficiency.
The key drivers that will impact the continued use of active archive in the future include the decreased cost of flash storage, greater automation, the rise of tiered storage workflows and the growth of tape in public and private cloud infrastructures.
Members of the Active Archive Alliance recently shared their perspective on the outlook for data storage and active archive in 2017. Here is a list of the top trends to watch:
Automated Policies and Artificial Intelligence Come to Storage
Greater automation and the use of artificial intelligence (AI) will simplify storage management and the use of active archives. New technology will help resolve two of the greatest challenges facing data management - data classifications and storage classifications. New software tools will use metadata to power automation providing a simple solution for data management.
Tiered Storage Workflows on the Rise
As the cost of flash storage decreases and disk continues to struggle to maintain its cost and capacity curve, customers will look to adopt tiered storage workflows. Flash's useable cost could drop below $1.00 per gigabyte while tape in large systems will cross below $.06 per gigabyte near line and below $.03 per gigabyte for offline or cold storage.
Energy Consumption Challenges Drive Active Archive Adoption
Active archiving will get a boost as organizations continue to seek ways to reduce energy consumption - a significant and growing component of operating expenses for today's rapidly expanding data centers. With servers and HDDs consuming more than 30% of the energy required to run IT hardware, data center managers will look for ways to reduce utilization of power-intensive hard disk drive technology. Less frequently accessed data will be moved to an active archive where it will remain accessible but consume less power on more economical storage tiers such as automated tape libraries on premises or in the cloud.
Onramps Drive Growth in Tape Usage
Tape usage will grow substantially as a key component of public and private cloud infrastructures for cold and active archive data. Tape's inherent attributes of low-cost, reliability and even portability combined with the increasing availability of file and object-based onramps to tape will accelerate adoption of tape beyond its historical role as a target of backup and recovery software. Solutions that offer data management intelligence and that integrate well with storage targets will alleviate historical management burdens associated with tape automation deployment, further fueling tape's penetration of cloud infrastructures where long term preservation and access to that data are required.
Cloud and Object Storage Bring More Flexibility to Archived Data
Object storage software can transform an archive into an active archive that is positioned between high-performance storage and tape. A combined cloud and object storage infrastructure provides additional capabilities allowing users to collaborate at LAN speeds and access data from any device, anywhere in the world. As content continues to grow, an active archive can scale seamlessly to billions of objects in a single namespace. Flexible, user-defined data protection options will be key in making this a reality.
Ethernet Continues to Gain Market Share
Ethernet is winning. There are still a number of ways to connect storage and active archives to compute - Fibre channel, Ethernet, SAS, SATA, and InfiniBand. Even though some of these connections are lighter weight from a protocol standpoint, Ethernet will continue to gain market share as the external host connection means.
The following Active Archive Alliance members contributed to this list: DDN Storage, Fujifilm Recording Media USA, Inc., Spectra Logic, Strongbox Data Solutions and Quantum.
Active Archive in the Summit SpotlightSubmitted by admin on Sun, 11/06/2016 - 12:05
By Rich Gadomski
I recently returned from the great city of Boston where I had a lot of fun with the locals who have a "wicked" sense of humor and a funny accent I can't imitate being from New York. I was in town facilitating our 8th Annual Global IT Executive Summit. The theme this year was "Exploring the New World of Storage." Boston was a fitting location given its history in shaping our country and the storage industry too. Speakers from the analyst, vendor and end user communities presented on the latest trends that are emerging in a new world of storage driven by so many innovations in flash, disk, tape, cloud and data management software.
One subject that kept popping up was the need to control runaway costs associated with unrelenting data growth that's compounded by long-term retention requirements. A common solution that many speakers referenced was the need for a well-planned tiering strategy where data moves as it ages from expensive tiers of primary storage to secondary, tertiary and even the cloud as a fourth tier. Speakers presented on various solutions to manage data growth with long-term retention requirements stemming from compliance regulations, protection of business assets and content, disaster recovery and big data analytics.
A key concept that got a fair amount of the spotlight in the tiering conversations was active archiving solutions. In an active archive, long-term data remains cost effectively online and easily accessible by leveraging innovative and integrated solutions that intelligently manage data across flash, disk, tape and the cloud. This is really where cost savings can come into play by matching data types to the right tier of storage.
It was pointed out by more than one speaker that an active archive solution can be implemented with existing storage equipment and without changing workflows while being transparent to the end user. Since we can't predict when archival data will be needed again and with that data being kept for longer and longer retention periods, what's needed are solutions that are cost effective and automatically migrate data from generation to generation of low cost yet reliable media such as LTO tape.
It was also noted during the conference that with today's advanced tape solutions, long-term affordable active archiving is a reality. Tape now offers: the lowest TCO for long-term storage thanks in part to its high capacity and very low energy consumption; the best reliability as measured in bit-error rate; transfer speeds greater than HDD at 360 MB/second; and a long archival life of 30+ years. Speaking of capacity, the potential for 220 TB on a single tape cartridge based on Barium Ferrite technology has already been proven. Barium Ferrite will enable achievement of the tape technology roadmap plans well into the future and will support active archiving for many decades to come.
Now if we can just get the Bostonians to pronounce the "r" in active archive, we'll be all set!
New Active Archive Webinar SeriesSubmitted by admin on Wed, 05/18/2016 - 09:31
Join us for an exciting webinar series presented by leaders from the Active Archive Alliance. Our goal is to align the education and technologies needed to meet the rapidly evolving requirements for data archive.
Alliance members strive to extend solutions beyond the high-end supercomputing and broadcast markets to the greater general IT audience that is in need of online data archive options. The following three-part series will help to educate and promote active archive strategies for data storage.
Thursday, June 2 at 8am Pacific/11am Eastern
Object Storage May be the Cloud You are Looking For
- Why use object storage?
- Learn more through examples from organizations currently using object storage in an Active Archive solution.
Hosted by: Quantum/HGST
Tuesday, June 7 at 8am Pacific/11am Eastern
Best Practices in Leveraging Active Archives to Solve Data Protection and Cloud Requirements
- What is block, file, object?
- How is this defining new approaches to active archive and object storage?
- What considerations should customers take into account when implementing?
Hosted by: Spectra Logic/DDN Storage
Tuesday, June 21 at 8am Pacific/11am Eastern
MLB Network Hits Home Run with Active Archive
- What is active archiving and why is it important today?
- A quick lesson: backup vs. archive - what's the difference?
- Technologies used for archiving: tape, cloud, disk, flash and data movers.
Hosted by: Fujifilm/StrongBox Data Solutions
Register now to learn more about how an active archive can give you access to all your data, all the time: http://bit.ly/1R6nUk2.
Active Archive Storage Solutions Featured at NAB 2016 ShowSubmitted by admin on Wed, 04/13/2016 - 08:14
In today's media and entertainment industry, workflows need to seamlessly integrate primary storage and application platforms to deliver performance and accessibility. Active archive has become invaluable for repurposing assets that already exist and require large amounts of storage. And, we're seeing continued innovation in the use of active archives for long-term data access and preservation.
All of the Active Archive Alliance members will be showcasing their solutions for active archive at NAB 2016 next week in Las Vegas. Here's a peek at what each one has planned and where to find them:
DDN Storage (Booth SL8016)
DDN Storage will showcase how its solutions like the high-performance MEDIAScaler™ Converged Media Storage can modernize your entire workflow in one easy step and deliver much more value and profitability to your organization.
Fujifilm Recording Media USA, Inc. (Booth SL7613)
Fujifilm will be exhibiting its Dternity solution, including new features like Partial File Restore and the Dternity VM – the world's first virtual machine active archive. Additionally, Fujifilm will be discussing their new Data Migration Services aimed at helping customers break their archives out of the past while integrating new technologies.
StrongBox Data Solutions, Inc. (Booth SL7613)
Visit the StrongBox team in the Fujifilm Dternity booth (SL7613) and discover how to simplify your workflow for long-term content preservation. StrongBox is giving away a PETABYTE of storage, so be sure to stop by the booth to enter.
Hewlett Packard Enterprise (Booth SL2425)
Hewlett Packard Enterprise will be demonstrating the HPE StoreEver Tape archive solution with the latest LTO-7 tape drives. This solution allows for M&E customers to easily integrate the cost effectiveness and reliability of LTO tape as if it were disk into their workflows for long-term archive of their media assets. Come see the solution in action in the StudioXperience booth (SL2425).
HGST (Booth SL9721)
HGST will showcase its 4.7PB Active Archive System; an object storage system that transforms silos of data storage into cloud-scale active archives, featuring its innovative helium-filled 8TB drives. Visit the booth to enter a daily drawing for a G-Technology 1TB G-Drive, or play the HGST Partner Passport Program game for a free t-shirt. Tweet a photo wearing your shirt to enter a daily drawing for an Amazon Echo.
Quantum (SL8416)
Quantum is announcing new partner integrations with both StorageDNA and Marquis to deliver comprehensive AVID ISIS archival solutions. These active archive capabilities enable ISIS administrators to manage their storage effectively, offloading completed or stalled AVID projects to Quantum Artico, Scalar tape libraries, Lattus object storage and Q-Cloud for near term and long term content retention and protection Stop by Quantum's booth (#SL8416) to learn more about this and many other exciting demonstrations.
Spectra Logic (SL11816)
This year at NAB Show 2016, Spectra Logic is a finalist for the IABM Game Changer Awards, will be giving a presentation about 'Genetic Diversity' April 20th at 10:00am PST, and has products on display in several partner booths. Interested in hearing about our hybrid storage ecosystem for media and entertainment? Come by Booth #SL11816 to learn how Spectra's deep storage solutions utilize active archive to grant users access to multiple tiers of highly scalable and affordable storage.
Be sure to visit these member booths and ask how an active archive can help you more easily manage and preserve your digital media assets.
Object Storage: An Innovative Approach to Active ArchiveSubmitted by admin on Wed, 03/02/2016 - 14:26
by Shreyak Shah
Data from all industries is growing with massive amounts of structured and unstructured data that is expected to quadruple in size by 2020. From Life Sciences, Media and Entertainment, Video Surveillance, and Oil and Gas to cloud providers many organizations are seeking ways to add more storage capacity and performance while still keeping their 'archived' data accessible and secure. One approach that is seeing a lot of traction is active archive, which is beneficial in terms of accessibility, flexibility, security and scalability and is ideal for organizations with data that requires long term retention and fast, easy retrieval.
Archives are undergoing a radical transformation, fueled by rapidly growing file sizes and new access requirements. Object storage enables IT managers to archive content sooner reducing the cost of tier-one storage. This preserves opportunities to monetize content while increasing access and speed at a substantially lower price point than traditional RAID disk-based solutions (and not much more than tape).
All too often businesses have had to offload months to years of historical transactions to secondary or tertiary data storage repositories. With the increased volume of data sources and speed of new data creation, keeping pace with these repositories has become a daunting task for any size of organization. More and more organizations require an active archive that allows for easy access to all pools of storage permitting the management of limitless volumes of data for better intelligence, competitive advantage or for regulatory requirements.
Object storage software can transform an archive into an 'active' archive that is positioned between high-performance storage and offline tape. The active archive solution brings it all together -- cost-effective spinning disk storage or online tape libraries, a collaboration platform, online content distribution and data protection. It also provides the foundation for a resilient object storage platform that delivers the highest level of data durability in the industry, surviving an entire data-center outage when deployed across multiple sites.
CTOs do not wish to purchase two to three years of storage in advance as it often leads to over budgeting and under utilization. Power, cooling and floor space are all wasted with this model. Object storage enables administrators to buy, manage and deploy exactly what is needed and to scale the performance and capacity as the organization expands.
It also allows an organization to take control of its content and easily create and manage public, private or hybrid clouds that sit securely behind a firewall. Administrators can also economically and efficiently manage capacity of up to double digit Petabytes with just one full-time employee and enjoy the benefits of the system's self-healing capabilities. As content continues to grow, an active archive can scale seamlessly to billions of objects in a single namespace. Flexible, user-defined data protection options are key in making this a reality.
Implementing an archive active creates incremental revenue opportunities and provides the ability to convert what has historically been a cost center into a revenue-producing asset. A combined cloud and object storage infrastructure provides additional capabilities, allowing users to collaborate at LAN speeds and access data from any device, anywhere in the world.
Data Migration in Long Term Active ArchivesSubmitted by admin on Mon, 02/15/2016 - 10:07
By Rich Gadomski
I recently attended the Storage Visions 2016 Conference to participate on a speaker panel entitled: "Saving Data Forever: Long Term Content Preservation and Archiving." The panel was in agreement that "forever" is a long time especially in the world of IT storage. While we were hard pressed to predict what storage technologies would be available 5,000 years from now as one attendee asked, our advice was to put an active archive in place that can routinely manage the migration of data from performance tier to economy tier and from older storage formats to new ones. The benefits of old to new migration typically include better performance, reduced footprint from greater density and lower total cost of ownership.
In a typical active archive environment, data management software migrates data by policy from expensive primary storage tiers to more cost effective tiers such as tape while maintaining the convenience of online file access to all of the data. Data can also auto migrate from older tape formats to new formats within a tier. Take LTO tape as an example; you can upgrade your LTO-5 drives to LTO-7 drives and auto migrate data in this tier from LTO-5 media to LTO-7 media. In doing so, you will get the benefits of an easier conversion with a big jump in per cartridge capacity from 1.5 TB to 6.0 TB, a much faster transfer rate going from 140 MB/sec to 300 MB/sec, thus reducing the amount of drives and robotic library slots required, and giving you more room to grow.
The ability to migrate is key to keeping up with relentless data growth for the long term. That is why having a reliable technology roadmap is so important. The LTO roadmap has been extended from eight generations to ten generations. Currently, the newest generation in the market is LTO-7 with a native capacity of 6.0 TB. Generation 9 and 10 have been added to the LTO roadmap where we can expect native capacity in generation 10 to rise to an impressive 48 TB, eight times greater than LTO-7, with an impressive native transfer rate of 1,100 MB/sec. These new generations will provide the ability for ongoing migration necessary to keep up with data growth and will ensure backwards compatibility with the two previous LTO generations as usual. No other data recording technologies can present a roadmap that has this much capability to look forward and plan for comprehensive data archiving.
Is generation 10 the end of the roadmap? Not likely, as IBM and Fujifilm announced back in April of 2015 the achievement of a new record of 123 billion bits per square inch in areal data density on linear magnetic tape using Barium Ferrite particle technology. This equates to a standard LTO cartridge capable of storing 220 TB of uncompressed data, 36 times greater than LTO-7 capacity! Given this achievement, the new LTO roadmap should be easily achieved and extended beyond generation 10.
This is good news for your migration strategy and long term, cost-effective active archiving!
Start the Clock: How to Get an Active Archive in Less than an HourSubmitted by admin on Mon, 01/18/2016 - 14:24
By David Cerf
More than 50 years ago, IBM and General Electric were grappling with computing lab's needs to process more than one computer function at a time. The pioneers of virtual machines needed a way to share mainframe resources with disparate users. Today, you can hardly glance down a list of IT news without seeing "virtual machine" or "virtualization." Businesses figured out it was much easier to be able to share resources for various functions instead of having separate, physical systems for every different process.
Why a VM-enabled Active Archive?
Scaling storage typically means adding another server to your rack, filling it up and the cycle continues. For businesses without the luxury of real estate, another rack might not be possible – you can only stack so high.
With a VM-archive, you can use a few GBs of space on an existing server plus a tape library or even the cloud to build a scalable active archive. This can be especially vital for businesses with multiple sites or multi-tenant architectures. The VM archive should be able to manage both file and object-based storage to support massively scalable workloads.
Plus, we like that instant gratification. Download, install and start writing data in minutes, not days. You aren't stuck waiting for a box to ship to you, and there's no additional hardware maintenance needed.
Upgrade, but don't Overhaul
If you've ever done any remodeling, you'll know that it's a lot less expensive to repaint the rooms and replace appliances rather than tear down the whole house and start from scratch. The same is true for deploying a VM active archive. Adding a virtual machine means you don't have to mount new hardware or send existing servers to their deathbeds. Instead, re-use and repurpose to save money and simplify getting started with your archive project.
A VM-enabled active archive allows you to start small and expand the archive as you need. This way, an archiving project is easier to get started with and tackle as data continues to grow.
Let's look at a few ways companies are leveraging VM-enabled archiving today:
- Got tape libraries? Add a VM archive to existing library and instantly create shared storage for nearline and archive.
- No local tape? No problem. A VM archive can keep active data locally and automatically create copies for off-site storage or the cloud for disaster recovery and data preservation.
- Looking to simplify multi-site storage management? A VM archive can provide on-site storage that automatically replicates to a second data center, the cloud, and multi-tenant architectures.
Our friend, Jon Toigo, has been exploring this concept in his latest video installment with Barry M. Ferrite, AI. Check out some of his videos here for more information on VM archiving.
Top 7 Data Storage and Active Archive Predictions for 2016Submitted by admin on Thu, 12/17/2015 - 12:50
Active archives have become a best practice for organizations that need to store and access large volumes of data. Stemming from recent technology advancements in the storage industry that have led to a variety of approaches to creating and implementing an active archive, more organizations are now benefitting from reliable access to all of their data all of the time.
Members of the Active Archive Alliance recently shared their predictions for data storage as it relates to active archives in 2016. Here is a list of the Top 7 active archive trends to watch:
The Move to Hybrid Cloud
Organizations are increasingly integrating the private cloud within their computing architectures to form stable and efficient hybrid cloud systems, which helps mitigate the limited capabilities and risks of public clouds. Cloud data centers are targeted and intermittently attacked by malware and hackers, making them one of the most threatened data centers. With the hybrid cloud, organizations can effortlessly adjust their public cloud resources to accommodate changes while they maintaining sensitive information within their private infrastructures.
Increased Prevalence of Active Archives
The declining price of hard disk drives and tape systems are making storage options more affordable and will allow for more organizations to implement archive actives. This coincides with a desire for better business insight with analytics using larger data sets and modeling to accelerate time to results. Data is becoming more valuable as the use of analytics increases and businesses want to use historical data to make better decisions. Active archiving with unified data across multiple tiers of storage allows businesses faster access to data, better insights and the ability to make more informed decisions.
Data Centers Become More Empowered
Data centers will become competitive forces used to drive business advantage because information is a major asset in today's modern global economy. Organizations will see the huge benefit that comes from monetizing archived data storage by making most data storage active, retaining storage for longer cycles, which is the basic premise and benefit of active archiving and using scale-out storage. The Media & Entertainment industry, and Life Sciences & Genomics are among the uses cases where historical information suddenly can turn into a hot business asset.
Seamless Storage Management Regardless of Technology
New software abstracts flash, disk, tape and cloud into simple, easy to use storage that works within current user behavior (no special or custom integration required). This intelligence will blur the line between performance storage and cost effective capacity storage and it will make tape and cloud as easy to use as the current c: drive. It will also reduce back up or even eliminate backup for fixed content. Archive copies will become the new standard and intelligent storage management will automatically provide data protection (numbers of copies, self-healing function) both for local and off-site copies. And it has the intelligence to know when to store the data in flash for performance and in tape/cloud for resiliency and cost-effective storage.
An End to Vendor Lock-in
There will be a move away from proprietary solutions that create "vendor lock-in" that lock up user data with vendor dependency, i.e. silo solutions or proprietary software and hardware. As we keep data longer or even forever, we will need solutions that are flexible, vendor neutral, support completely open formats and ensure that data can be accessible now and in the future.
Expanded Role for Advanced Data Tape in Active Archive Environments
With organizations seeking to keep access to all of their data and content indefinitely, new innovations in tape technology will make this possible and affordable in an active archive environment. Increased capacity coming from LTO-7 now at 15.0 TB compressed will help reduce TCO and boost performance with a transfer speed of 750 MB per second. The newly extended LTO roadmap to generation 10 will allow organizations to leverage investments already made in LTO systems and continue to migrate archived content well into the future. Finally, tape's role will continue to grow as a seamless part of the storage infrastructure and the cloud as it becomes easier to use as a file and object storage solution due to LTFS.
Increased Use of Object Storage
Companies will increasingly expand their active archives using object-based storage over file or block storage. Object storage systems allow relatively inexpensive, scalable and durable retention of massive amounts of unstructured data. With object storage, there is no file system hierarchy. The architecture of the platform allows the data pool to scale virtually to an unlimited size, while keeping the system simple to manage. The efficiency of object storage makes massively scalable active data archives affordable.
In addition, more organizations will adopt S3 as the de-facto standard cloud storage interface for managing large amounts of data in active archives. As organizations increasingly need to simplify and accelerate storage and retrieval for large amounts of data, extracting knowledge and information from historical deep archives as quickly and painlessly as possible, they will need a cost-effective and widely compatible object storage interface.
Active archive technologies are continuing to evolve and provide significant advantages to organizations desiring online data archives and the ability to quickly capitalize on the value inherent in their stored data – and with the trends we are seeing today 2016 should be another stellar year for active archiving.
The following Active Archive Alliance members contributed to this list: Crossroads Systems, Inc., DataDirect Networks Inc., HGST, Fujifilm Recording Media, Inc. and Spectra Logic Corp.
Should You Be Archiving? Here's How to Know for SureSubmitted by admin on Mon, 08/31/2015 - 07:56
By David Cerf
Active archiving is centered on the convergence of various storage technologies to create a balanced, accessible and affordable method for storing data long term. But, what if you don't know how much of your data belongs in this "archive" category? The truth is: the seemingly easiest method of use what you have, fill it up and buy more gets unnecessarily expensive. This is especially true if you're using a high-performance storage array for data that doesn't need those performance capabilities.
While each company may define archive differently, here are a few common criteria for "archival" data:
- Data is not accessed regularly
- Data was created more than 1 year ago and has not been accessed in more than 90 days
- Data has not been modified or accessed in more than 90 days
Sometimes companies simply don't know how much data they have that should be archived. Fortunately, there are free tools like the storage assessment at www.freemystorage.com that can help you answer this question by showing dynamic reports and transparent views into the state of your storage environments.
With detailed results on the active state of storage and the file make-up of active/inactive data, assessment tools can help organizations understand how to free up their storage and avoid unnecessary upgrades and over-provisioning. It can help organizations save thousands of dollars each year and reduce operating and capital expenses.
Why should end users think differently about their storage?
The Active Archive Alliance thinks there is a better option to meet the growing demand for storage. Data is growing faster than budgets, driving a need for more cost-effective storage and protection. While high-performance storage keeps line-of-business data and applications quickly available, up to 80% of data on primary storage is often inactive and doesn't need to claim expensive storage capacity. Storage needs to be intelligently balanced between active and inactive data, on-site and off, and must meet both performance requirements and budgets. Active archiving can deliver intelligent storage management that combines tuneable, user-defined policies for capacity optimization (no more over-provisioning) and will:
- Simplify nearline and archival storage management
- Free up storage capacity
- Reduce backup
- Simplify data protection
- Protect long-term content
- Improve storage costs by over 50%
Discover the benefits of reduced primary storage cost with automated data movement into an active archive solution that best fits your needs. Be sure to choose one that can transparently move files to your archive from primary storage like NetApp, Windows, Isilon and any CIFS/NFS or object storage.
Get started at FreeMyStorage.com for a free assessment to help you take control of your storage.