text:
T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease
- Manminder Kaur†1,
- Lucy JC Smyth†1, 3,
- Paul Cadden1,
- Seamus Grundy1,
- David Ray2,
- Jonathan Plumb1 and
- Dave Singh1Email author
© Kaur et al; licensee BioMed Central Ltd. 2012
Received: 21 February 2011
Accepted: 14 March 2012
Published: 14 March 2012
There are increased numbers of activated lymphocytes in the lungs of chronic obstructive pulmonary disease (COPD) patients. The clinical benefits of corticosteroids in COPD patients are limited. Our hypothesis is that lymphocytes play a role in this corticosteroid insensitivity.
To investigate the effects of the corticosteroid dexamethasone on lung lymphocyte cytokine production from patients with COPD compared to controls.
Cultured airway lymphocytes obtained by bronchoscopy from healthy non-smokers (HNS), smokers (S) and COPD patients were stimulated with phytohaemagglutinin (PHA) & phorbol myristate acetate (PMA), +/- dexamethasone. Supernatants were assayed for interleukin (IL)-2 and interferon (IFN)γ. Immunofluoresence was used to analyse changes in CD8 glucocorticoid receptor (GRα and GRβ) expression.
The inhibition of PHA/PMA stimulated IFNγ production by dexamethasone was reduced in COPD patients compared to HNS (p < 0.05 at concentrations from 0.1-1 μM). There was also a significant reduction (p < 0.05) in the mean inhibitory effect at 1 μM in COPD patients (54.1%) compared to smokers (72.1%), and in smokers compared to HNS (85.5%). There was a numerically reduced effect of dexamethasone on IL-2 production that did not reach statistical significance. There was no difference in GRα and GRβ expression in follicular CD8 cells between COPD patients (50.9% and 30.4% respectively) and smokers (52.9% and 29.7% respectively).
IFNγ production from COPD airway lymphocytes is corticosteroid insensitive. This phenomenon may be important in the poor clinical response often observed with corticosteroids.
KeywordsCOPD Lymphocytes Corticosteriods
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory airway disease. There are increased numbers of lymphocytes, particularly CD8 cells, in the lungs of COPD patients leading to the suggestion that COPD has an autoimmune component [1–3]. CD8 cells are increased in the airway lumen, sub-epithelium and parenchyma and their numbers increase proportionate to disease severity [1]. T lymphocytes from the airways of COPD patients produce pro-inflammatory cytokines, with evidence of both Th1 and Th2 cytokine production [4–8]. Furthermore, there is an increase in organised lymphoid structures called follicles within the lung parenchyma and associated with the bronchial tree [9]. These follicles may function as antigen presenting sites, further supporting the hypothesis that COPD has an autoimmune component [10].
Corticosteroids are the most widely used anti-inflammatory drug in COPD patients. Corticosteroids bind to the cytoplasmic glucocorticoid receptor (GR), forming a complex that can suppress inflammatory gene transcription [11]. However, the clinical benefits of corticosteroid therapy in COPD are limited [12–14]. Using peripheral blood derived lymphocytes, it has been demonstrated that corticosteroids have reduced effects on phytohaemagglutinin (PHA)-induced lymphoproliferative responses in patients with rheumatoid arthritis, ulcerative colitis and corticosteroid resistant asthma [15–18]. Our hypothesis was that COPD airway T lymphocytes also have reduced sensitivity to the effects of corticosteroids.
We report an investigation of the corticosteroid sensitivity of airway T lymphocytes from COPD patients compared to controls. The effect of dexamethasone on bronchoalveolar lavage (BAL) T lymphocyte cytokine production was investigated. In order to establish whether altered GR expression plays a role in corticosteroid sensitivity in lymphocytes; GR expression was quantified in CD8 cells of COPD patients and smoking controls.
Study subjects
Subject Demographics data are expressed as means (SD)
Sex (F/M)
Age (years)
66.9 (7.3)
62.4 (20.6)
39.5 (22.4)
65.2 (6.8)
66.1 (8.6)
Gold Stage (1/2/3)
1.8 (0.6)
2.0 (0.9)
3.4 (1.2)
2.01 (0.5)
2.06 (0.5)
FEV1% predicted
62 (12)
98 (19)
100 (15)
70.4 (11.5)
86.4 (19.3)
FEV1/FVC ratio
56 (13.8)
77 (5.7)
83 (6.0)
60.8 (11.1)
73.8 (7.7)
Pack year history
40.7 (26.4)
37.2 (28.5)
49.2 (39.7)
62.3 (29.5)
Current/Ex smoker
ICS Users
BAL Yield (mls)
91.0 (76.3)
115 (109)
190 (131)
Total Cell Yield/ml (× 106)
Total Lymphocytes (%)
Cell collection
BAL was collected from the upper lobes, or a lobe not affected by radiographic or endobronchial abnormalities: The bronchoscope was wedged in the bronchus and a maximum of 4 × 60 ml aliquots of pre-warmed sterile 0.9% NaCl solution were instilled into each lobe. The aspirated fluid was stored on ice before filtration (100 μm filter, Becton Dickenson). The filtrate was centrifuged (400 g/10 min at 4°C) and the cell pellet resuspended in RPMI 1640 medium supplemented with 2 mM L-glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin. Viable cell counts were determined by trypan blue exclusion (Neubauer hemocytometer) and adjusted to 1 × 106 cells/ml. Macrophages were depleted by adherence by 90 minute incubation in a 24 well plate at 37°C, 5% CO2. The non adherent cell count was adjusted to 2 × 106 cells/ml in supplemented RPMI 1640 medium with additional 10% (vol/vol) fetal calf serum. This cell suspension was then used for cell culture.
Cell Culture
1 × 105 cells (non adherent BAL), were seeded in a 96 well plate +/- dexamethasone (1, 0.1 & 0.01 μM) for 2 hours at 37°C, 5% CO2 in 200 μl RPMI-1640 media supplemented with 2 mM L-glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin and 10% FCS (v/v). Subsequently lymphocytes were activated by addition of PHA and phorbol myristate acetate (PMA), 10 μg/ml each. Cells were further incubated for 24 hours. This time point was chosen based on initial time course experiments over 2 days in 3 smoking subjects (data not shown). Supernatants (180 μl) were harvested by plate centrifugation 10 mins, 400 g, 4°C and transferred to a fresh 96 well plate for storage at -20°C prior to ELISA analysis.
ELISA assay
Release of interleukin (IL)-2 and interferon (IFN) γ was assayed on cell culture supernatants (either undiluted or up to 1:5 dilution with RPMI containing 10% FCS as required) using R&D systems ELISA duosets according to manufacturer's instructions.
Dual-label Immunofluorescence
Tissue blocks were obtained from an area of the lung as far distal to the tumour as possible, and processed as described previously [20]. Lung tissues were cut into 4-μm sections and lifted onto a polysine coated glass slide. For heat induced epitope retrieval in 0.01 M trisodium buffer pH 6 the lung sections were microwaved for 20 min at 800 W. A cocktail of CD8 with either GRα or GRβ primary antibodies diluted in 1.5% normal serum (Vector Labs, Peterborough, UK) with 0.5% triton × 100 was applied overnight at 4°C. Two CD8 primary antibodies were used to avoid applying a cocktail with two antibodies requiring the same species secondary antibody.
According to primary antibody species requirements, CD8 and GR were detected using either Alexa 568 conjugated goat anti-rabbit immunoglobulin IgG (1:200, Invitrogen, Paisley, UK) and Alexa 488 conjugated goat anti-mouse immunoglobulin IgG secondary antibodies (1:200, Invitrogen) respectively. Sections were counterstained with 4,6-diamidino-2-phenylindole (DAPI, Invitrogen). Omission of primary antibody from staining protocol was used as a negative control.
Image Analysis
The number of CD8+GRα+ and CD8+GRβ+ cells within inflammatory follicles were calculated and presented as a percentage of the CD8 population. Digital micrographs were obtained using a Nikon Eclipse 80i microscope (Nikon UK Ltd, Surrey, UK) equipped with a QImaging digital camera (Media Cybernetics, Marlow UK) and ImagePro Plus 5.1 software (Media Cybernetics).
Data analysis & Statistics
IL-2 and IFNγ data were not normally distributed, and so comparisons between groups were performed using a non-parametric ANOVA. If the ANOVA was significant (p < 0.05), then subsequent Mann Whitney U tests were performed for pairwise comparisons. Data for the percentage inhibition by dexamethasone were parametric. Paired t-tests were used to compare the effects of dexamethasone to PHA/PMA alone. Between group comparisons were performed by ANOVA. If the ANOVA was significant (p < 0.05), then subsequent two way comparisons were performed using an unpaired t-test. Immunofluorescence data were normally distributed; comparisons between groups were performed using unpaired t-tests. All analysis was carried out using GraphPad Prism version 5 (GraphPad Software, Inc., San Diego, CA, USA).
The cell yields/ml of recovered BAL fluid were numerically greater in COPD patients and smokers compared to HNS although this did not reach statistical significance (p = 0.2) (see Table 1). There was no difference between groups in the proportion of lymphocytes present.
Cytokine Production
Basal and stimulated cytokine release from healthy non smokers (HNS), smokers & COPD.
IFNγ release
IL-2 release
9.8 (3.9-651)
14.5 (6.2-39.8)
16.3 (0-75.1)
20.6 (0-453.6)
17.3 (0-83)
29.6 (0-102.8)
P value
519 (239.4-3062)
557.6 (39.6-1228)
1881 (87.1-19217)
954.9 (112.7-2612)
284.6 (27.6-15992)
474.2 (28.9-5011)
P value
Dexamethasone effects
Dexamethasone at all concentrations (0.01-1 μM) inhibited stimulated IL-2 production in all 3 subject groups. There was less inhibition of IL-2 production in COPD patients at all 3 concentrations, but these numerical differences between groups did not reach statistical significance (p > 0.05).
Within the COPD group, dexamethasone had similar effects on current and ex smokers for both IL-2 and IFNγ production (p > 0.05 for comparisons at each concentration) (data not shown).
GR expression in follicles
We show that the sensitivity of airway lymphocytes to corticosteroids is reduced in COPD patients. Our results implicate these cells as important players in the clinical phenomenon of corticosteroid resistance in COPD.
IFNγ plays a key role in Th1 type inflammation and cell mediated cytotoxicity (reviewed [21]). We show that corticosteroids have a reduced inhibitory effect on IFNγ production in COPD patients. The clearest difference in corticosteroid sensitivity observed was between COPD patients and HNS, although there was also evidence of differences between COPD patients and smokers, and between smokers and HNS at the highest dexamethasone concentration (1 μM). These data suggest that smoking itself reduces T lymphocyte corticosteroid sensitivity, and that the development of COPD further reduces corticosteroid sensitivity.
IL-2 is an integral cytokine for T lymphocyte proliferation [22]. There were numerical trends suggesting a reduction in the inhibitory effect of dexamethasone on IL-2 production in COPD patients compared to controls, but these did not reach statistical significance. This indicates that the effects of corticosteroids vary between T lymphocyte cytokines, with IFNγ showing more corticosteroid resistance in COPD patients compared to IL-2. The molecular mechanisms for such a difference have not been explored. The ability of corticosteroids to regulate the activity of transcription factors such as nuclear factor of activated T-lymphocytes (NFAT), activator protein 1 (AP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and activating transcription factor (ATF) may vary between the promoter regions of the IL-2 and IFNγ genes, and may be further altered by changes such as chromatin modulation that may occur in response to oxidative stress and inflammation in COPD [23].
Corticosteroid insensitivity has been observed in peripheral blood lymphocytes of corticosteroid resistant patients with asthma, ulcerative colitis and rheumatoid arthritis, as well as renal transplant recipients [14–16, 24]. IL-2 may play a key role in this phenomenon, as it can induce corticosteroid insensitivity in murine T lymphocytes [25] as well as in PBMCs from healthy volunteers by reducing GR binding affinity [26]. IL-2 mRNA levels are increased in the BAL of steroid resistant patients with asthma [27]. We speculate that IL-2 may play a role in the corticosteroid insensitivity observed in the current study.
IFNγ predisposes the airway microenvironment to a proinflammatory Th1 environment and plays a key role in host defence against viruses [28]. Pulmonary IFNγ levels are increased in COPD patients [29–31], and it has also been reported that COPD severity is related to the degree of IFNγ production by CD8 cells [32]. Viral infections can increase IFNγ levels in COPD patients [33, 34].
Our data suggests that that lymphocyte IFNγ production is corticosteroid resistant in COPD patients. This raises the possibility that virally induced IFNγ production in COPD patients is poorly suppressed by corticosteroids; the poor response of viral exacerbations of COPD to corticosteroids is an observation frequently noted by clinicians treating exacerbations.
The number of T lymphocytes in the lungs increases with the severity of COPD [1, 35, 36]. These T lymphocytes display an increased Th1 response [4, 7]. Results in this study suggest that IFNγ could play a central role in persistent Th1 inflammation in COPD, as it responds poorly to corticosteroids. Novel therapies that specifically target IFNγ activity may reduce Th1 inflammation in COPD, such as targeting of the janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway [37].
Our data suggests that IFNγ release from COPD lymphocytes is reduced compared to controls. This finding differs from studies that show increased IFNγ production from COPD lymphocytes [4, 7], and increased levels of IFNγ in the airways of COPD patients compared to controls [29–31]. We observed a similar trend for lower IL-2 production in COPD, although this did not reach statistical significance. Reduced cytokine production by alveolar macrophages has been reported from smokers and patients with COPD [38–40] which is thought to be due to a "blunting" effect of cigarette smoke on cell signalling mechanisms such as p38 mitogen activated protein kinase and NFκB [40]. It is possible that a similar effect is also present in COPD lymphocytes. However, as this phenomenon has not been observed in previous studies of COPD lymphocytes [35, 36], it is also possible that our findings for both IFNγ and IL-2 are due to random individual variation in a limited sample size rather than a true biological effect.
Corticosteroids bind to GR forming a complex that translocates to the nucleus to interfere with the binding of transcription factors such as NF-κB to the promoter regions of inflammatory genes [11]. A range of molecular mechanisms have been investigated as possible explanations for corticosteroid insensitivity, including the overexpression of the dominant negative splice variant isoform GRβ which is associated with corticosteroid insensitivity in different cell types [41–43] and is reported to be increased in steroid resistant patients with asthma and ulcerative colitis [44–47]. Studies in COPD patients have focused on the role of histone deacetylases which are recruited by ligand activated GR to reverse the unwinding of chromatin that occurs during inflammatory gene transcription; the activity of histone deacetylases has been reported to be reduced in COPD patients, leading to decreased corticosteroid activity [23]. It has been reported that GRα and β expression is reduced in the peripheral lungs of COPD patients compared to controls [48]. However, we observed no difference in either GRα or GRβ expression by CD8 cells within lymphoid follicles in COPD compared to smoking controls. This suggests that altered GR expression level is not the mechanism responsible for the corticosteroid insensitivity observed in the current study. We did not have access to sufficient samples from non-smoking controls for this analysis, as the majority of lung cancer patients are current or ex-smokers. Corticosteroid insensitivity is probably both a cell type and disease specific phenomenon, and further studies should address the mechanisms responsible for the corticosteroid resistance in COPD airway lymphocytes observed in the current study.
In conclusion, we have shown that T lymphocytes from the airways COPD patients display corticosteroid insensitivity. The mechanisms responsible for our findings require further study. Airway lymphocytes may play a key role in the corticosteroid insensitivity observed in COPD patients.
Activator protein 1
Activating transcription factor
Bronchoalveolar lavage
Chronic Obstructive Pulmonary Disease
Fetal calf serum
Forced vital capacity
Glucocorticoid receptor
Healthy non smoker
Nuclear factor of activated T-cells
- NF-κB:
Nuclear factor kappa-light-chain-enhancer of activated B cells
Phorbol myristate acetate
Authors' Affiliations
- Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD: The nature of small-airway obstruction in COPD. N Engl J Med. 2004, 24: 2645-2653.View ArticleGoogle Scholar
- Agusti A, MacNee W, Donaldson K, Cosio M: Hypothesis: Does COPD have an autoimmune component?. Thorax. 2003, 58: 832-834. 10.1136/thorax.58.10.832.PubMedPubMed CentralView ArticleGoogle Scholar
- Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight-White S, Green L, Hacken-Bitar J, Huh J, Bakeen F, Coxson HO, Cogswell S, Storness-Bliss C, Corry DB, Kheradmand F: Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med. 2007, 5: 567-569.View ArticleGoogle Scholar
- Hodge G, Nairn J, Holmes M, Reynolds PN, Hodge S: Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects. Clin Exp Immunol. 2007, 150: 22-29. 10.1111/j.1365-2249.2007.03451.x.PubMedPubMed CentralView ArticleGoogle Scholar
- Majori M, Corradi M, Caminati A, Cacciani G, Bertacco S, Pesci A: Predominant TH1 cytokine pattern in peripheral blood from subjects with COPD. J Allergy Clin Immunol. 1999, 103: 458-462. 10.1016/S0091-6749(99)70471-9.PubMedView ArticleGoogle Scholar
- Barczyk A, Pierzchała W, Kon OM, Cosio B, Adcock IM, Barnes PJ: Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2006, 117: 1484-1492. 10.1016/j.jaci.2006.02.013.PubMedView ArticleGoogle Scholar
- Barceló B, Pons J, Fuster A, Sauleda J, Noguera A, Ferrer JM, Agusti AG: Intracellular cytokine profile of T lymphocytes in patients with chronic obstructive pulmonary disease. Clin Exp Immunol. 2006, 145: 474-479. 10.1111/j.1365-2249.2006.03167.x.PubMedPubMed CentralView ArticleGoogle Scholar
- Di Stefano A, Caramori G, Capelli A, Gnemmi I, Ricciardolo FL, Oates T, Donner CF, Chung KF, Barnes PJ, Adcock IM: STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J. 2004, 24: 78-855. 10.1183/09031936.04.00080303.PubMedView ArticleGoogle Scholar
- Van der Strate B, Postma D, Brandsma C, Melget B, Luinge M, Geerlings M, Hylkema M, van der Berg A, Timmens W, Kerstjens H: Cigarette smoke induced emphysema: a role for the B cell?. Am J Respir Crit Care Med. 2006, 173: 751-758. 10.1164/rccm.200504-594OC.PubMedView ArticleGoogle Scholar
- Lambers C, Hacker S, Posch M, Hoetzenecker K, Pollreisz A, Lichtenauer M, Klepetko W, Ankersmit H: T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease. Clin Exp Immunol. 2009, 155: 466-475. 10.1111/j.1365-2249.2008.03835.x.PubMedPubMed CentralView ArticleGoogle Scholar
- Leung DY, Bloom JW: Update on glucocorticoid action and resistance. J Allergy Clin Immunol. 2003, 111: 3-22. 10.1067/mai.2003.97.PubMedView ArticleGoogle Scholar
- Loppow D, Schleiss MB, Kanniess F, Taube C, Jorres RA, Magnussen H: In patients with chronic bronchitis a four week trial with inhaled steroids does not attenuate airway inflammation. Respir Med. 2001, 95: 115-121. 10.1053/rmed.2000.0960.PubMedView ArticleGoogle Scholar
- Culpitt SV, Maziak W, Loukidis S, Nightingale JA, Matthews JL, Barnes PJ: Effect of high dose inhaled steroid on cells, cytokines and proteases in induced sputum in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 1999, 160: 1635-1639.PubMedView ArticleGoogle Scholar
- Soriano JB, Sin DD, Zhang X, Camp PG, Anderson JA, Anthonisen NR, Buist AS, Burge PS, Calverly OM, Connet JE, Petersson S, Postma DS, Szafranski W, Vestbo J: A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placebo. Chest. 2007, 131: 682-689. 10.1378/chest.06-1696.PubMedView ArticleGoogle Scholar
- Howe LJ, Stanford MR, Edelsten C, Graham EM: The efficacy of systemic corticosteroids in sight-threatening retinal vasculitis. Eye. 1994, 8: 443-447. 10.1038/eye.1994.105.PubMedView ArticleGoogle Scholar
- Corrigan CJ, Brown PH, Barnes NC, Szefler SJ, Tasi JJ, Frew AJ, Kay AB: Glucocorticoid resistance in chronic asthma: glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am Rev Respir. 1991, 144: 1016-1025. 10.1164/ajrccm/144.5.1016.View ArticleGoogle Scholar
- Hearing SD, Norman M, Probert CS, Haslam N, Dayan CM: Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes. Gut. 1999, 45: 382-388. 10.1136/gut.45.3.382.PubMedPubMed CentralView ArticleGoogle Scholar
- Kirkham BW, Corkill MM, Davison SC, Panayi GS: Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell mediated immune assay predicts in vivo responses. J Rheumatol. 1991, 18: 821-825.PubMedGoogle Scholar
- Global initiative for chronic Obstructive Lung Disease. [http://www.goldCOPD.com]
- Plumb J, Smyth LJ, Adams HR, Vestbo J, Bentley A, Singh SD: Increased T regulatory cells within lymphocyte follicles in moderate COPD. Eur Respir J. 2009, 34: 89-94. 10.1183/09031936.00100708.PubMedView ArticleGoogle Scholar
- Schroder K, Hertzog PJ, Ravasi T, Hume DA: Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004, 75: 163-189.PubMedView ArticleGoogle Scholar
- Smith KA: Interleukin 2: inception, impact & implications. Science. 1988, 240: 1169-1176. 10.1126/science.3131876.PubMedView ArticleGoogle Scholar
- Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, Barczyk A, Hayashi S, Adcock IM, Hogg JC, Barnes PJ: Decreased histone deacetylase activity in COPD. New Engl J Med. 2005, 352: 1967-1976. 10.1056/NEJMoa041892.PubMedView ArticleGoogle Scholar
- Langhoff E, Jakobsen BK, Ryder LP, Svejgard A, Thaysen JH: Recipient lymphocyte sensitivity to methylprednisolone affects cadaver kidney graft survival. Lancet. 1986, 327: 1296-1297. 10.1016/S0140-6736(86)91220-1.View ArticleGoogle Scholar
- Goleva E, Kisich KO, Leung DY: A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance. J Immunol. 2002, 169: 5934-5940.PubMedView ArticleGoogle Scholar
- Kam JC, Szefler SJ, Surs W, Sher ER, Leung DY: Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol. 1993, 151: 3460-3466.PubMedGoogle Scholar
- Leung DY, Martin RJ, Szefler SJ, Sher ER, Ying S, Kay AB, Hamid Q: Dysregulation of interleukin 4, interleukin 5, and interferon-γ gene expression in steroid-resistant asthma. J Exp Med. 1995, 181: 33-40. 10.1084/jem.181.1.33.PubMedView ArticleGoogle Scholar
- Schoenborn JR, Wilson CB: Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 2007, 96: 41-101.PubMedView ArticleGoogle Scholar
- Hens G, Vanaudenaerde BM, Bullens DM, Piessens M, Decramer M, Dupont LJ, Ceuppens JL, Hellings PW: Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy. Allergy. 2008, 63: 261-267.PubMedView ArticleGoogle Scholar
- Panzner P, Lafitte JJ, Tsicopoulos A, Hamid Q, Tulic MK: Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction. Chest. 2003, 124: 1909-1915. 10.1378/chest.124.5.1909.PubMedView ArticleGoogle Scholar
- Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG: IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol. 2010, 184: 1642-1652. 10.4049/jimmunol.0902605.PubMedView ArticleGoogle Scholar
- Zhu X, Gadgil AS, Givelber R, George MP, Stoner MW, Sciurba FC, Duncan SR: Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease. J Immunol. 2009, 182: 3270-3277. 10.4049/jimmunol.0802622.PubMedView ArticleGoogle Scholar
- Singh M, Lee SH, Porter P, Xu C, Ohno A, Atmar RL, Greenberg SB, Bandi V, Gern J, Amineva S, Aminev A, Skern T, Smithwock P, Perusich S, Barrow N, Roberts L, Corry DB, Kheradmand F: Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2010, 125: 1369-1378. 10.1016/j.jaci.2010.02.035.PubMedPubMed CentralView ArticleGoogle Scholar
- Makris D, Lazarou S, Alexandrakis M, Kourelis TV, Tzanakis N, Kyriakou D, Gourgoulianis KI: Tc2 response at the onset of COPD exacerbations. Chest. 2008, 134: 483-488. 10.1378/chest.07-2626.PubMedView ArticleGoogle Scholar
- Saetta M, Stefano AD, Turato G, Facchini FM, Corbino L, Mapp CE, Maestrelli P, Ciaccia A, Fabbri L: CD8 T-Lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Cirt Care Med. 1998, 157: 822-826.View ArticleGoogle Scholar
- Saetta M, Baraldo S, Corbino L, Turato G, Braccioni F, Rea F, Cavallesco G, Tropeano G, Mapp CE, Maestrelli P, Ciaccia A, Fabbri LM: CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Cirt Care Med. 1999, 160: 711-717.View ArticleGoogle Scholar
- Clarke D, Clifford RL, Jindarat S, Proud D, Pang I, Belvsi M, Knox AJ: TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein. J Biol Chem. 2010, 285: 29101-29110. 10.1074/jbc.M109.0999952.PubMedPubMed CentralView ArticleGoogle Scholar
- Armstrong J, Sargent C, Singh D: Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. Clin Exp Immunol. 2009, 158: 74-83. 10.1111/j.1365-2249.2009.03986.x.PubMedPubMed CentralView ArticleGoogle Scholar
- Kent LM, Fox SM, Farrow SN, Singh D: The effects of dexamethasone on cigarette smoke induced gene expression in COPD macrophages. Int Immunopharmacol. 2010, 10: 57-64. 10.1016/j.intimp.2009.09.021.PubMedView ArticleGoogle Scholar
- Chen H, Cowan MJ, Hasday JD, Vogel SN, Medvedev AE: Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists. J Immunol. 2007, 179: 6097-6106.PubMedView ArticleGoogle Scholar
- Neeck G, Klüter A, Dotzlaw H, Eggert M: Involvement of the Glucocorticoid Receptor in the pathogenesis of rheumatoid arthritis. Ann N Y Acad Sci. 2002, 966: 491-495. 10.1111/j.1749-6632.2002.tb04252.x.PubMedView ArticleGoogle Scholar
- Pujols L, Mullol J, Picado C: Alpha and beta glucocorticoid receptors: relevance in airway diseases. Curr Allergy Asthma Rep. 2007, 7: 93-99. 10.1007/s11882-007-0005-3.PubMedView ArticleGoogle Scholar
- Pujols L, Mullol J, Torrego A, Picado C: Glucocorticoid receptors in human airways. Allergy. 2004, 59: 1042-1052. 10.1111/j.1398-9995.2004.00635.x.PubMedView ArticleGoogle Scholar
- Kraft M, Hamid Q, Chrousos GP, Martin RJ, Leung DY: Decreased steroid responsiveness at night in nocturnal asthma is the macrophage responsible?. Am J Respir Crit Care Med. 2001, 163: 1219-1225.PubMedView ArticleGoogle Scholar
- Adcock IM, Lane SJ, Brown CR, Lee TH, Barnes PJ: Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med. 1995, 182: 1951-1958. 10.1084/jem.182.6.1951.PubMedView ArticleGoogle Scholar
- Sousa AR, Lane SJ, Cidlowski JA, Staynov DZ, Lee TH: Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform. J Allergy Clin Immunol. 2000, 105: 943-950. 10.1067/mai.2000.106486.PubMedView ArticleGoogle Scholar
- Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T: Kohgoy: Expression of glucocorticoid receptor in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology. 2000, 118: 859-866. 10.1016/S0016-5085(00)70172-7.PubMedView ArticleGoogle Scholar
- Marwick JA, Gaetano C, Stevenson CS, Casolari P, Jazrawi E, Barnes PJ, Ito K, Adcock IM, Kirkham PA, Papi A: Inhibition of PI3Kd restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med. 2009, 179: 542-548. 10.1164/rccm.200810-1570OC.PubMedView ArticleGoogle Scholar
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subset: commoncrawl


text:
I agree with everything you say. I was the second post on this thread and when I checked it again I knew I wanted no part of it. So I stayed out of it. And I will say it again I dont care what kind of a weapon anyone uses as long as it is legal in your state. If it gets you in the woods I am all for it!!WOW. Lots of misconsceptions here...mostly by people that have never done it.
I have killed lots of deer with a bow. Some stories...
I used to get laughed at by one of my bow hunting buddies because I had a 20,30,40,50,60 and even a 70 yard pin. Thats right, I used to shoot at a deer silhouette at 70 yards and was able to put it in the kill zone...everytime. Not some of the time. Everytime.
You'll never be able to use it he said. You can get 70 yards in the woods, its not clear enough. Too much stuff in the way...yada yada yada.
Until I shot one right through the heart...at 62 yards. An nice 8 point. That shut him up. If I had thought for a second that I could not make the shot, I would not have attempted it. The number of shots I didn't take probably exceeds the number that I did take.
I once whacked a another good deer point at 18 yards...this one a 10 point. It sounded like he got slapped with a 2x4. He jumped...looked around....and start grazing again. I had renocked, come to a draw and was about to put another in him...and then he started wobbling. I held off. In a few minutes he layed down and that was the end of that. I honestly dont think he had a clue.
One time a I shot another deer, a fair 8 point, the arrow passing through and stopping on the ground, buried about half deep. I was shooting 93 lbs...the arrows never even once stopped on any deer that I shot. That deer very casually walked over to the arrow stuck in the ground, started sniffing it, and then started licking it. In a few minutes it just layed down and that was the end of that.
One of the deer on the wall...looked right up at me. I'm about 15' up in a tree, this deer walks up and stops and looks right at me. I was in a thicket, and heard him coming. I was already at a full draw when he stopped. I let loose, the arrow hitting him square between the eyes, traveling through the neck, and exiting directly underneath the deer. The deer tried to jump, couldnt do it, landed on top of the arrow stuck in the ground, broke it half off, and quivered until it stopped moving. The whole thing lasted maybe 15 seconds.
I've got lots of stories. When I hear of someone telling me how cruel and inhumane it is, I dont say much because I already know that they have no clue of what they rant about and nothing I can say will change their mind.
It is a challenge, and shooting one with a gun when has killed dozens with a bow is sort of anti climatic.
Its about disipline. Skill. Knowing ones limitations. Having enough respect for the game to make the kill as quickly and painlessy as possible.
I dont expect most to be able to grasp those concepts, but for those that do...those that understand what I am talking about, I have the utmost respect.
Everyone else...I just dont waste much time trying to explain.


text:
09.00 - 23.00Contact Details
Phoomphun Mingkwan
296 Phayathai rd., Ratchathewi
Welcome to Playhouse ladyboy cabaret show, one of the best attractions in Bangkok, showing twice a night inside a high end theatre at The Asia Hotel in Siam. Featuring beautiful ladyboys, professionally trained, Thai dancers and stage designs that create scenes from around the world, all brought together to the sound of famous musical hits. It is a fun and amazing thriller of a nightlife entertainment show that spans classical ballet, tap, hip-hop and contemporary styles. Don't know what to do in Bangkok tonight? Come and enjoy a great nightlife experience at the Playhouse ladyboy cabaret show!
By Car
Asia hotel.
By Bus
Bus number 16, 50, 36, 511 to Ratchathewi intersection and enter to the Asia hotel.
By Other
Easily walk from Siam Square or MBK cross the Hua Chang Bridge to Asia hotel.
By BTS
Take off at Ratchathewi station and walk into Asia hote


text:
Granger Optical Repairs Poster Print (Landscape)
Parody logo referencing Hermione Granger's experience in repairing Harry's glasses.
The print is produced using premium print paper and the highest quality print methods for a stunning finish. The print is available in A3, A2 and A1 dimensions, meaning you can easily find low cost frames at this size to showcase the artwork which is printed using the highest quality high contrast UV life ink onto Photographic Fujicolour paper to ensure a stunning finish.
Shipping is £3.99 globally on orders less than £30. Shipping is FREE for all orders over £30. Orders are delivered within 5-7 business days. If you have a query about delivery for a product which you have already ordered, please contact us.
If you don't absolutely love it, we'll take it back!
If you're not happy with your order, please contact us as soon as possible. In all cases we'll ask you to provide photographs of the item, including a close up of any tags/labels. To help us respond to you quickly, please include the order number in your message to us.
We have a money-back satisfaction guarantee, so whatever the problem, we're happy to work with you to fix it.
- Tags: 740329, albus-dumbledore, dizinga-featured, emma-watson, fictional-universe-of-harry-potter, film-and-tv, harry-potter, harry-potter-character, harry-potter-film-series, harry-potter-alliance, harry-potter-and-the-chamber-of-secrets, harry-potter-and-the-chamber-of-secrets-film, harry-potter-and-the-goblet-of-fire, harry-potter-and-the-goblet-of-fire-film, harry-potter-fandom, hermione-granger, hogwarts, j-k-rowling, list-of-harry-potter-characters, list-of-harry-potter-related-topics, list-of-spells-in-harry-potter, literature, magic-in-harry-potter, parodies-of-harry-potter, the-wizarding-world-of-harry-potter


text:
Create SlideDecks on your WordPress blogging platform. Manage SlideDeck content and insert them into templates and posts.
slidedeck folder and all its contents to the
/wp-content/plugins/ directory
Embed a SlideDeck button in the rich text editor or the button in the sidebar in the post/page view.
You can also place a SlideDeck in your template or theme via the PHP command slidedeck(); Just pass the ID of the SlideDeck you want to render and an associative array of the styles you want to apply to the SlideDeck itself. For example:
`<?php slidedeck(12,array('width'=>'100%','height'=>'300px')); ?>`
Where 12 is the SlideDeck's ID. You can also see this code snippet in the sidebar of the SlideDeck editing interface.
Requires: 2.8.6 or higher
Compatible up to: 3.5.2
Last Updated: 4 years ago
Active Installs: 4,000+
Got something to say? Need help?


text:
CFast Cards Hurting Your Wallet and Your Recording Time? "C-Box" Has A Solution
4K video camera systems are now quickly becoming prevalent in the market, and with even more on the horizon, it's a safe bet to assume that many filmmakers stepping up to 4K aquisition will be investing in peripherals and other accessories that are needed to capture and edit at that resolution. One of these expensive extras comes in the form of CFast 2.0 cards. Before shelling out for one though, check out a product that instead, lets you record to much less expensve SSD drives.


text:
This is your resource to discuss support topics with your peers, and learn from each other.
I am trying to create an RSAPublicKey object using the following code.
RSAPublicKey rsaPublicKey=new RSAPublicKey(cryptoSystem, exponent.getBytes(), (modulus.getBytes());
It throws an InvalidKeyException .
The exponent and modulus are stored in a file in json format. could any one help? any experts out here with RSA encryption knowledge.?


text:
Breakers NBL finals loss 'an afterthought'
New NBL team, new beginnings and new challenges.
That's the message from Breakers coach Paul Henare as his side look to take on their 2015/16 NBL grand final opponents Perth on Friday.
The Wildcats trumped their distant foes 2-1 in the three-game NBL final series last season, with two wins at their Perth Arena home.
However for Henare, who has taken over the Breakers' reins this year from Dean Vickerman, the 2015/16 outcome hasn't been given much thought.
Both sides have made major squad changes for the 2016/17 campaign, with the Breakers losing star point guard Cedric Jackson in particular.
Perth had looked a more athletic side than last year in their seven-point round-one loss to the Brisbane Bullets.
They lost guns Nathan Jawai and Jermaine Beal in the off-season but would be no less dangerous, according to Henare.
"Whether some of the guys use that as extra motivation or not, I'm not sure, but certainly as a team we don't see it that way," Henare said.
"I haven't really put much brain power into the fact it's a rematch of last year's final."
The Breakers surprised Jackson's much-fancied Melbourne United outfit 76-71 last weekend, with new imports Ben Woodside and Akil Mitchell impressing.
The side's fourth quarter was particularly strong as they laid on 28 points, including a 15-point streak, to leave United in their wake.
Henare said his side had overcome their interrupted pre-season, in which they lost six matches, and were looking to establish consistency.
"Continuing to improve the on-court chemistry, that's the biggest one, just continue to build and build with healthy bodies," Henare said.
More in News
'It's like time froze': Mystery as French family vanishes from homeThe Independent
Fears over uni group's 'white pride' ambitionsThe Wireless
Police slash spending on snitchesRadio New Zealand
Maori children deserve justice: DevoyNZ Newswire
'Every moment, there's a chance they will get killed'Radio New Zealand
'Obama set for return to politics'The Independent


text:
Created attachment 557143 [details]
- Log in at:
- In PROFILE section: choose a photo
Result: comparing en-US and he pages, in Hebrew page:
- Profile photo is not displayed right under the button "Choose Photo..."
- "use original" link is displayed at right side of the image instead of left side under parallel to the link "delete original"
Thanks for filing this. Due to resource constraints we are closing bugs which we won't realistically be able to fix. If you have a patch that applies to this bug please reopen.
For more info see http://micropipes.com/blog/2014/09/24/the-great-add-on-bug-triage/


text:
The Panteao Productions Make Ready with Pat Rogers: Basic Carbine is a great way to start building upon your skill set in using a carbine or brushing up on your fundamentals. Pat Rogers, founder of EAG Tactical and retired Marine and Sgt in NYPD, takes you through all the steps needed towards building a solid foundation. In a one-on-one setting, Pat reviews with you the various accessories and gear available for the carbine platform. He covers weapon manipulation, trigger reset & dry firing, zero procedure, target engagement drills, shooting from intermediate and prone positions, turns, multiple target engagement, shooting on the move, and more. If you are serious about carbine use, this is a must have video.
Panteao "Make Ready with Pat Rogers: Basic Carbine"
- Product Family #: 3161652935
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The statements and opinions expressed within Customer Reviews reflect each author's personal perspective and do not imply endorsement by MidwayUSA, its Employees or any other organization. Customers should in no way infer that MidwayUSA has validated review information as safe, accurate or appropriate.


text: :For the Filipino illustrator and painter, see Malang (painter).Malang is the second largest city in East Java province, Indonesia. It has an ancient history dating back to the Mataram Kingdom. The city population at the 2010 Census was 819,708. During the period of Dutch colonization, it was a popular destination for European residents. The city is famous for its cool air and the surrounding country regions of Tumpang, Batu, Singosari, and Turen. People in East Java sometimes call it "Paris of East Java." Malang was spared many of the effects of the Asian financial crisis, and since that time it has been marked by steady economic and population growth.


text:
In a message dated 11/17/98 10:51:59 PM Central Standard Time, firstname.lastname@example.com
<< ***********
Why does Piedmont Gold need shade?
I think it needs water, the sun might not be the only problem but the lack of
soil moister. Hosta in sun need a lot more water than they do in shade.
To sign-off this list, send email to email@example.com with the
message text UNSUBSCRIBE HOSTA-OPEN


text:
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- 06-07-2014, 07:15 AM Thread Author #1
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Galaxy S3 Application Help
Hello, new here so sorry if this is in the wrong section.
My issue is with the Facebook Messenger app... Basically new friends who I have not talked to through messenger before do not receive my messages if I send one before they do but I can see and reply to theirs if they message me first.
When I send the first message it takes around 10 seconds for it to actually appear on the conversation but doesn't show in my message inbox on the app.
I have tried uninstalling and reinstalling but hasn't made a difference and im not sure what else to try.
Any help would be greatly appreciated
- 06-11-2014, 12:49 PM Thread Author #2
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text:
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text:
Find Your Cruise
Was on IE in Dec. Flat pin.
So much for my memory!
I went with round pin & it was my 2nd time on IE.
Two pin round from memory.
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text:
Boston — There was far more drama after the game than there was during the game.
The dust had long since settled on the Milwaukee Bucks' 106-95 victory over the Boston Celtics B team Wednesday night at the TD Garden rest home and the Bucks were dressing in their locker room while keeping an eye on the game between Miami and New Jersey that would determine Milwaukee's first-round playoff opponent.
Bucks coach Scott Skiles had come out of the visiting coaches' room to discuss his team's game with reporters as the Heat and Nets were headed into the first overtime.
Inside the locker room, guard Charlie Bell was monitoring the Heat and Nets on his nifty new iPad while the eyes of other Bucks were glued to their own mobile devices.
"Double-overtime?" said a disbelieving Bucks guard John Salmons, expressing the feelings of his teammates, as the game between the Nets and Heat dragged on.
The locker room had pretty much cleared out by the time the Heat defeated the Nets in two overtimes, which meant that the Bucks (46-36) would play Atlanta in the first round of the playoffs and the Celtics would play the Heat.
"Everybody's kind of scoreboard watching right now," said Milwaukee's Jerry Stackhouse as the Heat and Nets were playing the second overtime. "The good thing about it, though, is we took care of our business. We could have been playing here laying an egg, but that's not who we are. We came out and competed and now we'll deal with whatever. We came out and played and I think that was the right thing to do."
The Bucks led by five at halftime, began pulling away from the Celtics late in the third quarter and then led by as many as 18 in the fourth quarter.
Boston coach Doc Rivers set the tone for the evening before the game when he let it be known that since the Celtics were locked into the fourth seed for the playoffs, the "Big Three" of Paul Pierce, Ray Allen and Kevin Garnett, along with starting center Kendrick Perkins, would not play. Rivers started forwards Glen Davis and Michael Finley, guards Rajon Rondo and Marquis Daniels, and center Rasheed Wallace, and played some of the team's lesser-known players big minutes.
"I think we're ready (for the playoffs)," said Rivers. "I mean we have to be. It's not like we can say, 'Can you hold up for a week and let us get ready?' So I think we'll be ready."
The Bucks, though, speculated on possible ramifications down the road of Rivers' decision to sit his stars.
"That's dangerous," said Stackhouse. "The basketball gods might not like that. It can come back and . . . but you never know. It is what it is. A lot of teams rest guys at this stage. They were pretty much locked into where they were going to be. They were going to be the fourth seed regardless, so you can't take anything away from what they do. We played the game, played hard, and won the game."
What was guard Brandon Jennings' reaction when he became aware of how the Celtics were going to play the game?
"Just start out ahead and get through it," he said. "Really, just play basketball. They were still fighting a little bit. But it's kind of different when you don't see Ray Allen, Paul Pierce, and KG out there playing. But we were like, 'Oh, all right. We'll play.' "
Skiles opened the game with his normal starters but didn't overwork any of them and gave all of his players a nice run. Stackhouse and Luke Ridnour scored 17 points each for the Bucks, who shot 50.8%, and Ersan Ilyasova added 15, including a couple of big three-pointers late in the third quarter when the Bucks were pulling away. Dan Gadzuric pitched in 14 points and nine rebounds.
Now the Bucks can finally let the fun begin.
"We have a flight home to take a deep breath and feel good about it a little bit," said Skiles. "And then start getting ready."
Said Stackhouse, "The playoffs really start (Thursday). We start to prepare."


text:
The present proposal seeks support from NIDA to participate as one of the Research Centers for the National Criminal Justice Drug Abuse Treatment Research System (CJ-DATS) collaborative. Specifically, the UCLA Integrated Substance Abuse Program (ISAP) proposes to become the Pacific Coast Research Center (PCRC), representing California and Oregon. The purpose of CJ-DATS is to establish a nationwide research system designed to evaluate and test interventions in multi-site studies that address systems-level interventions and issues related to integrating public health and public safety approaches for drug-using offenders, particularly those in prison or on parole. The selected CJ-DATS Research Centers will undertake this research in three phases. Phase I will involve the establishment of a Steering Committee and a study plan;Phase II will involve pilot testing of assessments and intervention protocols;and Phase III will be devoted to conducting multi-site research studies and preparing research reports and publications. As requested in this NIDA RFA, we have provided three research concepts for consideration by the CJ-DATS collaborative. These proposed studies, each of which included random assignment, address: (1) institutional readiness to accommodate a treatment program;(2) the impact and outcomes of involuntary treatment in prison;and (3) the need for reliable and effective assessment of prison treatment participants for community treatment placement. The PCRC would combine ISAP researchers'experience of more than 3 decades of criminal justice treatment research with the experience of 4 established providers of treatment for prisoners and parolees (Phoenix House, Walden House, Mental Health Systems, and New Directions Northwest) and the California and Oregon Departments of Corrections. Thus, the PCRC is well positioned to be a major contributor to NIDA's CJ-DATS initiative.
|Visher, Christy A; Hiller, Matthew; Belenko, Steven et al. (2014) The effect of a local change team intervention on staff attitudes towards HIV service delivery in correctional settings: a randomized trial. AIDS Educ Prev 26:411-28
|Pearson, Frank S; Shafer, Michael S; Dembo, Richard et al. (2014) Efficacy of a process improvement intervention on delivery of HIV services to offenders: a multisite trial. Am J Public Health 104:2385-91
|Belenko, Steven; Hiller, Matthew; Visher, Christy et al. (2013) Policies and practices in the delivery of HIV services in correctional agencies and facilities: results from a multisite survey. J Correct Health Care 19:293-310
|Friedmann, Peter D; Green, Traci C; Taxman, Faye S et al. (2012) Collaborative behavioral management among parolees: drug use, crime and re-arrest in the Step'n Out randomized trial. Addiction 107:1099-108
|Prendergast, Michael L (2011) Issues in defining and applying evidence-based practices criteria for treatment of criminal-justice involved clients. J Psychoactive Drugs Suppl 7:10-8
|Prendergast, Michael L (2009) Interventions to promote successful re-entry among drug-abusing parolees. Addict Sci Clin Pract 5:4-13
|Grella, Christine E; Greenwell, Lisa; Prendergast, Michael et al. (2008) Diagnostic profiles of offenders in substance abuse treatment programs. Behav Sci Law 26:369-88
|Grella, Christine E; Greenwell, Lisa; Prendergast, Michael et al. (2007) Organizational characteristics of drug abuse treatment programs for offenders. J Subst Abuse Treat 32:291-300


text:
June 10th, 2011
Dad was just thankful he was allowed to wear pants at all.
(submitted by Sarah)
Dad was just thankful he was allowed to wear pants at all.
(submitted by Sarah)
"Wait, I feel a burp coming."
No, I don't want three wishes. I want you to leave.
The boy was sent home from school because he forgot his other stilt. Father begs for mercy, 'cause Mom is rally really pissed!
Finally got it figured out.
1) the woman is sitting on the end of the couch. there is no more couch after that. Perspective and #2 is causing the look of being giant.
2) the man is sitting in a collapsed seat/chair. he's actually quite sunk in.
3) the man is wearing "Couch fabric" color pants & socks, and his legs are spread out.
4) the boy with the "long leg" is slipping forward off the dad's leg, thus causing the illusion of the long leg.
I can now sleep. 😛
I think that's definitely Marnie from the Thanksgiving story.
Is amazed that none of the kids seem to be noticing what is going on around them, they are just happy to be getting their picture taken. This truely is an Awkward picture.
Mom: "Wait! I am receiving a vision."
Dad: "Now? Seriously? In the middle of a photo shoot?"
made me laugh!
me too :-)))
That is Dad's leg his other one is tucked up under his knee, I often sit like that.
The 3 kids are piled on him. As for freakishly big mom, she is sitting on the arm of a separate sofa while dad is sunk low in the plaid chair. The looks on the adult faces is what
makes this photo awkward.
That was the last time he would ever ignore Marnie's order to put a bow in the baby's hair.
notice dads pants look a lot like couch upohlsery
It almost looks like something paranormal is occurring, as if they are in a vortex or something.
The woman looks as though she may be feeling something strange and the man has an odd look as though he sees something. That would explain the odd size of her and the kid's leg. Maybe.
Awfully nice of Dad to take the kids to Madame Toussaud's.
I knew someone would 'wax' lyrical.
She's a Giant and has trouble fitting in.
Oh, good one China. 🙂
There's another kid behind the baby; that's whose lap she's (the baby) sitting on and who the leg with the white tennis shoe belongs to. The other leg is bent and propped up on her dad's right leg. Their head and upper body are hidden at this angle, because they're behind the sister with the blue dress on. She's kinda hunched up on the chair leg, because someone's behind her.
Actually, she's on her dad's left knee, not a chair leg or arm.
All this insight, and you never acknowledge the giant woman in the photo?
I had to acknowledge the giant woman? Wasn't aware there were rules to commenting on the photos…or that there were Comment Police!
The mom is sitting on the arm of the couch and the dad/kids are sitting on a lower couch/sitting area. I can't exactly figure out the boy's long leg, but it is somewhat possible.
This pic has got to be photoshopped: 1. the woman is freakishly tall, 2. the random leg below the baby, and 3. the woman isn't sitting on anything!
It has to be photoshopped: 1. The woman isn't sitting on anything, 2. She's freakishly tall, 3. There's a random leg below the baby.
I am vanting another baby. You vill put your seed in me NOW!!
I do believe that boy got the legs of his mother and the torso of his father.
"Kids, don't touch Mummy. She just finisher her hair an makeup. We shall admire from afar".
I just need to know whose leg that is under the baby with the white tennis shoe. That's all I want to know. Then I can carry on with my day.
THAT is a very good question!! I'm glad you pointed that out. Wish I had an answer for you!
LAUGHING……..Oh so hard right now…….tears!
Now I will not get a thing done until I figure it out too.
Hi, seriously, this is my picture.. and it's not photoshopped at all… I still have a picture to prove! I uploaded the picture by the way..
rrrrrrrrrrrright Sarah…then tell us…whoes leg under the baby???
Actually, if you look at the photo you can see that the girl
Is sat back nearly as far as the boy. Her dress ant the baby(making her lean forward) makes her look as if she is sitting far forward.
The boy is leaning back. And while he is younger, it is not impossible that he is much taller that his sister too. Inheriting his mothers genes
Sarah, please tell us….To whom does the blue leg belong?????
Somehow this makes me think of the white witch in the Narnia story.
Exactly what I thought!
Yes Dear, whatever you say Dear.
Hey, big mama!
No. Wire. Hangers.
Wait…where are the pants??? LOL
" I am Gigantor the Amazonian Princess, you will carry all the spawns and wear plaid!"
Your comment made me nearly spew coffee on the screen!
I woke my toddler up from a sound sleep, laughing so hard!!!
Is there another kid under there, or does that little boy have freakishly long legs?
To whom does the random leg (blue pants/white shoe) belong????
Wow. This made me think of Darryl Hannah in "Attack of the 50 Foot Woman".
His wife is a giant among man. Geez!
She looks like a statue.?.
wow…she looks very tall…and he looks very obedient.
This picture raises so many questions.
'Who are you? What are you doing in my trailer? And how come my children can't seem to see you?'
I hope that's just the angle of the photo and the seating positions that's giving her that giant appearance.
Looks like mom is contemplating eating one of the children. and dad is hoping to spare them.
Holy crap! Is she really that much taller than him or are my eyes playing tricks on me because of where she's sitting?
Maybe I'm wrong here, but doesn't the boy on the left look way too young to have such a long leg under his baby sister? And if that's not his leg, (which I am convinced it's not) who the heck's leg is it?!
Please tell me this is some sort of odd foreshortening effect…
Is that some sort of gargantuan mannequin?
That is exactly what I thought!
Look kids — there is your mommy — I know she looks just like the ladies at the Sears store, but THIS is your mommy


text:
The heat contributed to more injuries than usual during the Flying Pig Marathon on Sunday. None was reported to be serious, though, and nothing else dampened the fun-filled spirit of the 16th annual marathon.
More: Runners go off course during Pig
Winners: Reyes, Robilliard cross the line first
More: Flying Pig race times
Cincinnati Police Capt. Paul Broxterman said no Flying Pig-related arrests were made during the three-day, 10-race event that drew a record 36,131 participants from 50 states and 19 countries. That was welcome news for the police, who have had to deal with a few bizarre incidents in recent years.
"People were well-behaved," Broxterman said. "That's a testament to how well-run this event is."
It was an ideal, sun-splashed Sunday morning with temperatures in the low 70s – ideal, at least, for the estimated 150,000 spectators. Two runners were taken to the hospital with minor injuries; others were treated on-site by marathon medical personnel, Flying Pig spokeswoman Jackie Reau said. She added there were more injuries than typical on marathon day, but did not provide specific numbers.
Look for yourself in this short video from the 16th annual Cincinnati Flying Pig Marathon over the weekend. Lots of smiles, a few grimaces and plenty of cheering. Photos by Liz Dufour and Meg Vogel.
A heightened police presence was noticable again this year, the second Flying Pig since the Boston Marathon bombings in April 2013. Police and race organizers did not release the number of law enforcement officers who were on duty Sunday along a marathon course that stretched across Downtown, Covington, Newport, Mariemont and several neighborhoods on Cincinnati's East Side.
Last year, Cincinnati police arrested a Colerain Township man for carrying a gun near the starting line just minutes before the race began. David Moore has since pleaded guilty to menacing by stalking and carrying a concealed weapon. In 2011, police arrested a man for running naked in the marathon.
Some 15 to 20 police officers could be spotted around the finish line for several hours. Officers dressed in riot gear were stationed near the starting and finish lines, and in Hyde Park and Oakley, police said. Bomb-sniffing dogs also were present.
"It's the new norm," Reau said.
A flying pig's-eye-view view of the Flying Pig Marathon course at a virtual 600 miles per hour. The Enquirer
The 2013 Flying Pig was one of the nation's first big-city marathons after the tragedy in Boston, where two bombs killed three and injured more than 250 others. The support for Boston and the victims continued to be strong at this year's Pig. Several runners and spectators wore blue "Boston Strong" shirts and bracelets; others donned Boston Red Sox caps and jackets.
"I really didn't think about it at first," said Fairfield resident Vicky Thompson, who walked Saturday's 10K race and was a spectator Sunday. "Then when I was getting ready to start, I looked over and saw guys in riot gear. I was like, 'Oh, yeah.' The way the world is, something could happen, but you have to go about your life."
Sergio Reyes wins his third straight Flying Pig Marathon.
In recent years, the Flying Pig has been named among the top 10 most fun races in the world by Runner's World magazine – and the marathon lived up to that billing again.
Fans came dressed as all sorts of characters – Elvis, Superman and, of course, pigs. Two fans dressed in gorilla suits and cheered runners and walkers as they passed through the intersection of Reading Road and Elsinore Place.
Marathoner Barry Goldmeier, of Rockville, Maryland, juggled three balls during his five-hour and 56-minute run.
Lots of posterboard signs hovered above spectators standing on pedestrian bridges overlooking Pete Rose Way and along the barricades near the finish line by U.S. Bank Arena. One bright, pink sign read: "Beat it! Don't eat it!" It included a drawing of a big, fat pig.
And there were the usual interesting messages on runners' shirts: "Kickin' Assphalt" and "WTF: Where's the finish?"
"The atmosphere makes you be able to run when your legs cannot run anymore," said P.J. Ball, the women's marathon runner-up. "My legs stopped working coming down Eastern Avenue. If it wasn't for the crowd and its energy, there's no way I would've gotten to the end.
"The marathon is what captures the human spirit of our city." ⬛


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More Studies Pointing to Anabolic Key
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Bearded Beast of Duloc
Max Brawn
Join Date: Jul 2009
Location: Louisiana
Posts: 76,876
Training Exp: 20+ years
Training Type: Powerbuilding
Fav Exercise: Deadlift
Fav Supp: Butter
Reputation: 2774165
More Studies Pointing to Anabolic Key
More studies is pointing to the anabolic key for lifters, especially naturals....and the key is...
caloric intake
There is a tendency in the bodybuilding realm to walk on the side of clean, calorie restricted diets that are close to maintenance. But as revealed in the studies, and as I have stated before (and taken quite a bit of heat about), the fastest way to gain muscle mass is to eat like a king.
An interesting find in the Forbes' study was that the benefits of overeating stop at 14 days. So it appears that cycling calorie intake is the way to go.
Note that there is muscle mass gain without resistance training.
Here are some quotes...
Test subjects having a fixed protein intake of 1.25 g/kg/day but with different total-energy intakes, showed that an increase in calories of 15% enhanced nitrogen retention from 7.2 mg/kg/day to 23.8. When energy intake was increased to 30% above requirement, nitrogen balance rose to 33.3 mg/kg/day.1 Basically,
adding calories to the diet is anabolic
, and I don't just mean it raises insulin levels--by adding just one anabolic hormone, you'll never get optimal gains in muscle. You need the whole array of anabolic hormones, and they have to be in the correct ratio to each other. This is what happens during puberty.
(In a) study by Forbes, et al., entitled the "Hormonal Response to Overfeeding,"2 it was demonstrated that when test subjects started with a maintenance-calorie-intake diet and then went on a nutrition program that provided 1,200 to 1,600 extra calories a day,
their blood tests showed a progressive increase in IGF-1, testosterone, and insulin [which doubled in 14 days!]
, all in concert with an increase in lean body mass. However, the
hormone levels peaked and began to decline on day 14
of the high-calorie diet! This is a very important observation.
IndentationBy day 21, the test subjects in this study gained 3-6 lbs of lean body mass and gained a few pounds of bodyfat as well. However, these test subjects did not perform any resistance exercise
, and the excess food provided only six percent of energy from protein, and the test subjects were women--we don't know yet, but the testosterone boost could be even greater in men, leading to more muscle accumulation.
In a 12-day study conducted by Jebb, et al., reported very recently in the American Journal of Clinical Nutrition,7 entitled "Changes in Macronutrient Balance During Over- and Underfeeding Assessed by 12-Day Continuous Whole-Body Calorimetry," it was shown that when male test subjects went from a maintenance-calorie-intake diet to an overfeeding diet [approximately 3,600 total calories a day],
within 12 days, they gained 4.38 lbs of lean mass and put on just 2 lbs of fat
. The same study showed that when test subjects went on a pretty drastic [around 1,000 calories a day] diet for 12 days, they lost, on average, 4.6 lbs of bodyfat and only 2.4 lbs of lean mass.
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text:
- Details
- Specs
- Reviews
DETAILSDesigned for everyday use, this 38 litre pack is a steadfast partner for backcountry and close-to-area tours and features a lowered, wide, flat body of the pack that is shaped to the contours of the lumbar vertebrae and that holds and transfers the pack's load through the body's centre of gravity. Stable support and with easy access to items in the main compartment while in transit, this is a skier's/snowboarder's tool kit. Separate compartments keep shovel, safety gear, food and extras balanced and organized, and a reinforced, external wrap system is robust enough to carry skis and boards (A-frame, split and diagonal carry of skis; horizontal and vertical carry for snowboard). This pack is large enough to accommodate all your necessities for day tours.
- Short Description
- Panel loading main compartment with front U-zip access and organizational�slot
- Secondary storage compartment with external side zipper access, and alternative access from inside the main compartment
- Front pocket with internal organizational pocket and key�clip
- Internal zippered pocket inside side-access secondary storage compartment
- Internal hydration pocket with�zip
- arc-quintic-38-p
- Brand Name
- Arc'teryx


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2013 Kia Soul Exclaim 1.6 from North America
Worrisome on the highway
I apparently left one of the interior lights on and awoke to a dead battery the following morning. In my view, there should be an automatic timer on any lights once the key is removed from the ignition, as I am accustomed on all my cars. My fault though. Kia was great in responding and recharging the battery after a thorough check of the vehicle.
General Comments:
The Soul is a wonderful small SUV with great headroom. Unfortunately, its interior is designed for kid tastes, but that didn't prevent me, an old timer, from choosing the Soul. I thought that it was the best buy for the bucks. I test drove it around the neighborhood and found it to be good - not great.
It was not until I purchased the vehicle and had it on the road, that I realized there is maybe a major worrisome flaw. The vehicle does not hold the road well on turns at high speeds. I suspect that this is because the wheelbase is too short and the center of gravity too high. I am not an engineer, but I have driven many, many different cars over the years, and have never felt this uncomfortable about any vehicle on the highway. The car is otherwise a great buy, but the flaw makes it unacceptable, and I'm shopping around, even though my car is brand new.
Would you buy another car from this manufacturer? Don't Know
Review Date: 1st March, 2013
31st Mar 2013, 18:42
Best bang for the buck? Seriously, try the Suzuki Kizashi.
1st Apr 2013, 22:51
What do you expect, seriously? You bought a Kia!
31st Oct 2013, 21:23
I have two of these cars, and I think this review is wrong. I'm not sure what the reviewer means making turns at high speeds. The vehicle is more top heavy than, say, a Miata, but unsafe? Not in the least. I've put 25k miles on my 2013 and have never felt unsafe - except when trying to pass on a 2 lane highway, because it's not super fast!
25th Jan 2016, 03:41
Seriously? Many people are unaware of the strides Kia is making globally. Styling, fit and finish are outstanding. Kia is now #2 in quality, lagging only behind Porsche.


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Witness the beauty and wonder of the 105 island Langkawi archipelago off Malaysia's northern coastline. Drift along the waves for a few hours on the power of a warm ocean breeze. Spend your quality time on this lush stretch of water fishing, sunbathing, swimming, island hopping or simply napping the hours away as you await the gourmet lunch being prepared for you on the boat.
Destinations included:
We pride ourselves in creating personalised travel experiences that suit all your preferences and needs.
With this tour you can:
Set sail. Wait for the gentle tug of your fishing rod while your best friends nap on the deck. Build a gentle sway in a hammock beneath the rattle of a clean white sail. Propose to the one you love in the shimmering, crimson haze of the Malaysian sunshine as it sparkles off the water. Blow hard on your snorkel and dive deep amongst a feeding frenzy on a coral reef. Periodically dive into the water amongst the 105 island archipelago of Langkawi to cool off during your tanning session.
Drift along the coast of Langkawi main island, which is dotted with rice paddies and jungle-clad hills, or frolic around the outlying lush spits of sand and anchor off an uninhabited slice of paradise with a stretch of beach all your own. Whatever your preference a Langkawi customized private cruise could be the perfect way to seek it out. Create a memory that stands out every bit as much as the islands themselves, lying separated from northern Malaysia's coasts by the Straits of Malacca. The choice is yours entirely. Finish up with a gourmet buffet lunch before drifting back to the mainland and spending the afternoon at your leisure.


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offshore wind companies
We offer integrated development, engineering, construction and AO&M services for utility-scale renewable energy projects. From offshore wind to wave and tidal, we bring to projects the considerable skills and experience acquired over 30 years in the renewables industry. RES Offshore is part of the RES Group, one of the world`s leading renewable energy project developers. ...
based in Kings Langley, UNITED KINGDOM.
wpd acts as a strong partner for the development, financing, construction and operation of wind farms on land and at sea. The medium-sized company, founded in Bremen, Germany, in 1996, is today playing a leading role in helping to convert energy supplies and supporting the protection of our climate. In Germany, wpd has earned itself a leading position in the expansion of ...
based in Bremen, GERMANY.
WeserWind combines manufacturing technical know-how with the goal of offering cost-efficient foundation structures for offshore wind farms. From fabrication to installation—WeserWind takes an integrated approach to the costs for offshore foundation structures.
based in Bremerhaven, GERMANY.
SBM Offshore N.V. is a pioneer in the offshore oil and gas industry Worldwide. Our activities include the engineering, supply, and offshore installation of most types of offshore terminals or related equipment. In addition, SBM Offshore owns and operates its own fleet of Floating (Production) Storage and Offloading units. SBM Offshore has a track record of developing ...
based in Schiedam, NETHERLANDS.
MPI Offshore is a world leader in offshore windturbine installation, operating the world`s largest and most powerful windturbine installation vessel, MV MPI Resolution. MPI has a trackrecord of over 200 windturbines and will expand it`s fleet in 2010 and 2011 with two impressive new builds, the Discovery and the Adventure.
based in Stokesley, UNITED KINGDOM.
SSC Wind GmbH has been supplying technical services to the wind energy sector for over ten years. With capacities of 1.0 to 6.0 MW, more than one thousand wind turbines erected and commissioned throughout Europe are testimony to our wide-ranging experience – both on- and offshore.
based in Wildeshausen, GERMANY.
VertAx Wind Ltd is a British company that has engaged with a number of leading industry players to develop its patented design of a multi-megawatt vertical axis wind turbine generator for use in the offshore environment. The company`s strategy is to develop a design that is simple, robust and cost effective, whilst moving away from traditional supply chains. Longevity, ...
based in London, UNITED KINGDOM.
Wind as an alternative non-emitting energy source will continue to established itself in the years to come. Energy production by means of wind power will become more effective. Worldwide, greatly diverse wind environments require modern, innovative technologies which bring high yields. Throughout the entire value-added chain of wind energy, the cost and the yield of ...
based in Rostock, GERMANY.
Carter Wind Energy is a manufacturer of next generation wind turbine technology that is self-erecting and designed for utility, distributed, and micro-grid power generation applications in the most remote, extreme environment locations which may not be viable with conventional wind turbine technologies. Wind energy is more commercially available than ever, but accounts ...
based in Wichita Falls, TEXAS (USA).
NaiKun Wind Energy Group Inc. is a British Columbia-based renewable energy company with offices in Vancouver, Masset and Skidegate. Located on B.C.'s northwest coast, where the wind resource is one of the strongest and most consistent in the world, NaiKun Wind's 396MW offshore wind project would generate enough energy to provide electricity to 130,000 B.C. homes. The ...
based in Vancouver, BRITISH COLUMBIA (CANADA).
Since 2013 Primus Windpower is manufacturer of portable wind power turbines and maker of the of Air Breeze Turbine, Air 30 Turbine & Air 40 Turbine. The Primus Wind Power AIR Breeze wind turbine is trusted by sailors around the world and recommended as the best high-energy output turbine by Yachting Monthly. Its optimized electronic controls deliver energy quietly and ...
based in Lakewood, COLORADO (USA).
Avanti was founded in 1885 as a ladder factory in a backyard downtown Denmark's capital Copenhagen. Today, Avanti Wind Systems is the leading world market producer of any kind of safety systems and complete tower internals kits for wind turbines. Avanti has factories and offices in 10 countries all over the world. The first production back in 1885 was wooden ladders and ...
based in Hillerød, DENMARK.
WIND & SUN TECHNOLOGIES Group specializes in highly efficient and reliable converters and inverters (Helios-Systems), in addition to the global administration and monitoring of photovoltaic and wind power stations. Our business has a long standing tradition of exceptional after-sales-service, with the 1GW of power generated from previously installed plants bearing witness ...
based in Viladecans, SPAIN.
Wind Measurement International is a joint venture between Obelisk Energy and Heidra, the leading wind monitoring and assessment provider in the UK, the Republic of Ireland and Worldwide. Using high quality equipment and leading edge wind measurement techniques, Wind Measurement focuses on providing accurate data and predictions for wind resource assessment on your site, ...
based in Berkhamsted, UNITED KINGDOM.
The Polish Wind Energy Association (PWEA) is a non-governmental organisation established in 1999 (previously known as "VIS VENTI Association for Supporting Wind Energy"). PWEA acts on the basis of the Associations Act. The Association is an organization supporting and promoting wind power development which aim, realized through joint activities of its members, is to ...
based in Szczecin, POLAND.
RainWise Inc. manufactures professional weather stations and other meteorological equipment for consumer and industrial applications. We feature solar powered wireless weather stations, data loggers, rain gauges, advanced cellular telemetry, PV array environment monitors, wind measurement loggers, anemometers, barometers, thermometers and a variety of other weather ...
based in Trenton, MAINE (USA).
Kingspan Environmental is a company with an international reputation specialising in fuel and energy storage, wastewater management, solar thermal, wind energy and hot water energy storage. We also offer Monitoring and Service packages for all the products we supply, powering homes and businesses around the world. Through continued investment in research and development ...
based in Co. Armagh, NORTHERN IRELAND.
To assist in assessing investments in wind energy projects and support wind farm quality, SGS works as an independent global service provider carrying out consultancy, inspection, testing, supervision, monitoring, management, verification and certification services for both onshore and offshore wind farms.
based in Camberley, UNITED KINGDOM.
SeaRoc provides specialist products and services to the Offshore Renewable Energy Sector. We offer our clients marine, engineering, QHSE and geographical information system (GIS) data management expertise together with a range of bespoke applications to support the development, construction and management of offshore projects. We have a reputation for excellence which has ...
based in Chichester, UNITED KINGDOM.
ZephIR Lidar provides hub height and turbine mounted accurate wind measurements for wind energy and meteorological applications onshore and offshore with leading accurate wind lidar products, ZephIR 300 and ZephIR DM. ZephIR 300 wind lidar: Hub height wind measurements reduce the risk of, and increase the value of wind energy projects. Accurate wind lidar measurements ...
based in Herefordshire, UNITED KINGDOM.
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Dr. Cathryn Chappell
Associate Professor
Columbus Center
Office Number:
Dr. Cathryn Chappell, Associate Professor, joined Ashland University in 2004. Her areas of expertise include assessment, multicultural education, peace education, and social justice issues. Her primary areas of scholarship include post-secondary prison education and libraries as community centers. She earned her B.A. in psychology and M.Ed., and Ed.D. in the social and psychological foundations of education at the University of Cincinnati.
I work in...
The undergraduate and graduate programs offered by the Department of Educational Foundations and Instruction help each individual develop the personal and professional qualities needed to become an agent of change who positively influences all students, their schools and our... Read More
Faculty Spotlight
Dr. Jane Piirto, Trustees' Distinguished Professor, has been at Ashland University since 1988. She teaches in the Department of Inclusive Services & Exceptional Learners and...Read more


text: Most of the Japanese restaurants in the area barely have Japanese cooks. Unless I'm very mistaken, Aoba is 100% authentic. The food is prepared fresh, nothing I've tried is bad, we've been several times with my family. The highlight are the grilled veggies that are included with every meal. Staff is always very pleasant without being overly aggressive, in other... 更多


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"We don't do God," his spokesman, Alastair Campbell, insisted while he was Prime Minister. But since leaving office, Tony Blair has converted to Roman Catholicism, launched a faith foundation and yesterday gave his strongest endorsement of the church yet.
Speaking at a conference in London organised by the Holy Trinity Brompton Church, Mr Blair warned that a world without faith would be on a path towards "tragedy and disaster". He explained how his "journey of faith" began in choir school in County Durham at the age of 10 after his father Leo, a "convinced atheist", had suffered a serious stroke.
"The headmaster of the school called me into his study and he said 'I think we should kneel and say a prayer for your father'," said Mr Blair. "I said to him, 'I should tell you my father does not really believe in God'. I will never forget what he said to me – he just said to me 'but God believes in him, so let us kneel and pray'. That made a big impact on me."
Mr Blair has repeatedly come under criticism for his personal beliefs which were a continual source of anguish during his time in office. Reflecting on it last year, he said he was "too sensitive or too cautious", arriving at the conclusion that "if I started talking about religion, it was going to be difficult".
That self-doubt appeared to have vanished yesterday when, addressing the audience of 4,000, he said he believed that the sense of something "bigger and more important" was crucial for the health of society. "For a long period of time, what people thought was that as society became more developed and as we became more prosperous, that faith would be relegated, that it would become a kind of relic of the past," he said. "I think that essential obligation of humility for humanity is deeply important. It is what allows us to make progress, it is what keeps us from ideology or thought processes that then treat human beings as if they were secondary to some political purpose."
In his address, Mr Blair repeated a story of how, during his time in power, he had frequently thought of signing off his speech with "God bless Britain" but was talked out of the idea. "We had this debate on and off but finally one of the civil servants said in a very po-faced way 'I just remind you Prime Minister, this is not America' in this very disapproving tone, so I gave up."
Reflecting on the backlash he endured in the aftermath of sanctioning the Iraq war, he said there were some days he had not wanted to read the newspapers. He added that having teenage children had helped protect him from growing "hard" and "too tough" in the face of criticism. "I remember when I appeared on The Simpsons – this was when I thought I had done quite a lot as prime minister – one of my kids said to me 'you know, that is the first thing I have really been proud of'."
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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: SAMSUNG 840 Series 2.5" 500GB SATA III Internal Solid State Drive (SSD) MZ-7TD500BW
Pros: Faster than stock drive.
Still running strong
Cons: None
Other Thoughts: Installed in my macbook pro 17"READ FULL REVIEW
This review is from: SiliconDust HDHR3-CC HDHomeRun PRIME 3-Tuner US CableTV with CableCARD Stream Premium Channels and Cut the Cord
Pros: Works with Mythtv
Simple to setup
Pretty small
Cons: None so farREAD FULL REVIEW
This review is from: WD Red 2TB NAS Hard Disk Drive - 5400 RPM Class SATA 6Gb/s 64MB Cache 3.5 Inch - WD20EFRX
Pros: Replaced a drive in my Netgear readyNAS NV+ No problems so far.
Cons: NoneREAD FULL REVIEW


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Changing of the guard as Kevin Ollie replaces Jim Calhoun
Updated 1:00 pm, Friday, December 28, 2012
STORRS -- They all wore suits, Kevin Ollie's a shiny gray, Warde Manuel's a duller shade of the same color. To their right, University of Connecticut President Susan Herbst leaned into the microphone, speaking of a "legend," calling him "our legend." Her jacket was slightly darker than Manuel's.
The legend sat below Herbst as she addressed the audience. His eyes drifted downward, although he occasionally glanced up at the Gampel Pavilion rafters: Diagonally, there were plaques on the walls memorializing his Big East dominance and, next to them, the "Huskies of Honor."
On Thursday afternoon, Jim Calhoun, the ultimate Husky of Honor, formally announced his retirement as head coach. He did it wearing a blue UConn polo.
"Basketball to me, all you needed was a boy, a ball and a dream," said Jim Calhoun, now the special assistant to the athletic director.
The dream now belongs to Kevin Ollie, 39, the 18th coach in program history.
An assistant for the past two years and a former UConn point guard in the mid-'90s, Ollie agreed to a one-year contract that will be terminated on April 4, 2013. Following a season of evaluation, Manuel will either award Ollie a long-term deal or open a national search.


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Evading a question is one thing. Issuing a flat denial is another.
So, if the Rams quickly move for Eagles quarterback Donovan McNabb when the trading period opens at midnight ET, I'd be a little surprised.
"There's been no talks about Donovan," Rams coach Steve Spagnuolo told Sirius radio's Scott Ferrall on Wednesday night.
Pressed further, Spagnuolo said, "No, there were no conversations."
Separately, Rams vice president Kevin Demoff used an NFL.com chat to explain how difficult it can be to draft good quarterbacks after the first round -- something to keep in mind as the Rams decide whether to draft Sam Bradford first overall.
"One thing that should be noted is the success rate of quarterbacks drafted in the second round is far worse than that of those drafted in the first round," Demoff wrote. "The only second-round quarterback to make the Pro Bowl in recent memory was Drew Brees, and he would have been a first-rounder if there had been 32 teams in the NFL when he was drafted."
Kordell Stewart (1995 draft) and Jake Plummer (1997) went to Pro Bowls as second-round choices, although neither enjoyed exceptional careers by elite quarterback standards.
"I believe at the end of the year, 18 of the 32 quarterbacks starting in the NFL were first-round picks, and the next most prolific round was undrafted," Demoff wrote. "If you look at the playoffs last year, nearly all of the starting quarterbacks were first-rounders, with the exception of Brees, Brady and Warner, who all could be in the Hall of Fame. The percentages are much better in the first round, but with the reward comes great risk."
From 1996 to 2006, about 41 percent of first-round quarterbacks became Pro Bowl players. The rate dropped to 22 percent in the second round, 13 percent in the third round, 6.7 percent in the fourth round and zero percent in the fifth and seventh rounds. Nearly 17 percent of sixth-rounders became Pro Bowlers (Tom Brady, Matt Hasselbeck, Marc Bulger and Derek Anderson).
I did not count quarterbacks drafted from 2007 forward, figuring they were still early in their careers. Also, quarterbacks drafted earlier probably received extra chances to succeed.


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Loughton, CM16 5HW
07960 304435
21-Feb-13 to 21-Feb-14
Tue, Thu, 10am, Pls check for dates
0 months to 9 months
Little Lotus is pleased to offer Baby Massage & Baby Yoga classes to mums and babies in the Loughton and surrounding areas.
Little Lotus runs Baby massage classes suitable from four weeks to crawling, and Baby yoga classes suitable from twelve weeks to crawling.
We also offer one to one classes and specialist sessions to help colic and encourage unsettled babies to relax.
For more information and course dates, contact Anna on 07960 304435 or visit www.little-lotus.co.uk
Times and prices are subject to change. Contact venue before setting out.
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The Parlour Brings an "Irish-Style Gastro-Steakhouse" to Midtown
Introducing the Irish-gastro-steakhouse.
The Parlour Midtown, a West 30th Street outpost of the Upper West Side Irish pub, is gearing up for a soft open next week and, following a clean health inspection earlier this month, should open its doors to the public in April. The website promises "New York City's first Irish-style gastro-steakhouse," offering contemporary takes on traditional Irish dishes, such as Shepherd's Pie and Colcannon croquettes, as well as Guinness and several New York state IPAs on tap.
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Try Dental Defense - Daily Dental Health Formula for Dogs and Cats
* Bird Biotic - Doxycycline comes in two dosing forms. a pre-measured 100mg packet of powder or 100mg tablets. Please be sure to order the correct dosing type for your application. If not sure which product dosing would be most effective we suggest you speak to a veterinarian for advice.
Bird-Biotic - Doxycycline Hyclate can be used for systemic and local infections in racing pigeons, pet and exotic birds.
Ingredients: *Each single packet - or - tablet contains: Doxycycline hyclate (active)..............................100 mg
Directions for single use packets:
Add contents of one packet (100mg Doxycycline hyclate active) to 8 ounces of drinking water. Make a fresh solution daily. Continue treatment for 7-10 days.
Direction for tablets: Dissolve 1 tablet (100mg) into 8 ounces of drinking water. Make a fresh solution daily. Continue treatment for 7-10 days.
Caution: Not for human use. Keep out of reach of children. For animal use only. Store in a cool dry place. Not to be given to birds that are intended for food use.