text:
The increasingly invasive activities of the state stinks. I was hoping to make it through life without hearing television commentators repeatedly utter the word transvaginal. Yet that intimate territory is where the country headed in February, and it is where we will increasingly return as long as the government keeps assuming a greater role in our private ... MORE
Walter E Williams: Media Dishonesty And Race Hustlers
Inflaming passions to push a self-serving agenda. When NBC's "Today" show played the audio of George Zimmerman's call to a Sanford, Fla., police dispatcher about Trayvon Martin, the editors made him appear to be a racist who says: "This guy looks like he's up to no good. He looks black." What Zimmerman actually said was: "This guy looks like he's up to no good ... MORE
Labels: Blacks, crime, hate crime, liberalism, media bias, Obama, police, political correctness, race
VIDEO: John Stossel - Technically, That's Illegal
Politicians keep Americans in a perpetual state of lawbreaking.
Labels: entrepreneur, government, law, lawyers, licensing, poverty, regulation, rules, safety
Debra Saunders: Obama, The Happy Drug Warrior
The president's war against the states. Why is the federal government under President Obama arguably tougher on medical marijuana operations than it was under George W. Bush? That's the question that antidrug-war groups have been asking themselves for months. In 2008, antiprohibitionists thought an Obama administration would not tread on medical-marijuana ... MORE
Labels: doctors, drug war, federal, government, law enforcement, medical marijuana, states' rights
Jonah Goldberg: Very Few Of The Above
Obama's energy policy is rather picky. In his speech before the Newspapers Association of America/American Society of News Editors Wednesday, likely GOP presidential nominee Mitt Romney accused the president of changing positions to get reelected. For instance, Romney charged that "as president," Obama "delayed the development of our ... MORE
Labels: coal, economics, electricity, energy, EPA, fossil fuels, government, green, Obama, oil, policy
VIDEO: Top Cop Chooses Not To See Voter Fraud
Even after stranger given Attorney General Eric Holder's ballot.
Labels: DOJ, election, Eric Holder, fraud, justice, politicians, regulation, suspicion, voter ID, voting
John Fund: Why We Need Voter-ID Laws Now
The attorney general can't look away anymore. Attorney General Eric Holder is a staunch opponent of laws requiring voters to show photo ID at the polls to improve ballot security. He calls them "unnecessary" and has blocked their implementation in Texas and South Carolina, citing the fear they would discriminate against minorities. I wonder what ... MORE
Andrew Napolitano: Hope For The Dead
Human aspiration needs freedom to flourish. What does freedom have to do with rising from the dead? When America was in its infancy and struggling to find a culture and frustrated with governance from Great Britain, the word most frequently uttered in speeches and pamphlets and letters was not safety, taxes or peace; it was freedom. Two acts of ... MORE
Labels: freedom, government, individual liberty, law, monetary, religion, safety, tax, tyranny
Wendell Cox: California Declares War On Suburbia
State's climate-change goals provide the impetus. It's no secret that California's regulatory and tax climate is driving business investment to other states. California's high cost of living also is driving people away. Since 2000 more than 1.6 million people have fled, and my own research as well as that of others points to high housing prices as the principal factor. ... MORE
Labels: bureaucracy, California, climate, economics, government, housing, regulation, restrictions
Daniel Mandel: What Is Judicial Activism?
Striking down an unconstitutional law is doing its duty. Last week, President Barack Obama warned the Supreme Court against the perils of judicial activism. Specifically, he warned against the Court ruling unconstitutional Obamacare. "Ultimately," said the President, "I'm confident that the Supreme Court will not take what would be an ... MORE
Labels: Constitution, judicial activist, justice, law, Newt Gingrich, ObamaCare, ruling, Supreme Court
Sheldon Richman: Is Serfdom An Executive Order Away?
The unchecked powers of the executive. Sometimes a step back helps to provide perspective on a matter. President Obama provided such a step with his March 16 Executive Order—National Defense Resources Preparedness. In it we see in detail how completely the government may control our lives—euphemistically called the "industrial and ... MORE
Labels: emergency, executive, freedom, individual liberty, loans, military draft, Obama, production
Ben Stein: Our Presidential Know Nothing
Besides the Constitution, what else doesn't he know? Here, in outline form, is why the pronouncements from President Barack Obama, warning the Supreme Court to not overturn Obamacare. are so chilling: 1. The President supposedly went to Harvard Law School, graduated from same, was Law Review President of the Harvard Law Review at ... MORE
Labels: Congress, Constitution, defense, free market, Obama, oil, Supreme Court, taxpayer, workers
Nick Schulz: Minimum Wage, Maximum Stupidity
Why Congress should not raise minimum wage. When economic times are tough, it's tempting to want to push for an increase in the minimum wage. Supporters see it as giving the deserving poor a badly needed raise. If we only mandate that employers raise the pay floor for their employees, those who earn the least will see a nice pay bump. ... MORE
Labels: economics, employee, employer, minimum wage, opportunity, poverty, skill, unemployment
Victor Davis Hanson: Freedom Or Fairness In 2012?
A conflict of visions. This should prove to be an ideological election about the economy. Not all campaigns are so clear-cut. Sometimes moderate Republicans raise taxes (as George H. W. Bush did); at other times, pragmatic Democrats cut spending (as Bill Clinton did). But this year, Mitt Romney, the likely Republican nominee, will run an ideological ... MORE
Labels: economics, election, fairness, freedom, government, liberty, Mitt Romney, Obama
Ethan A. Huff: Total Obedience Required By Police State
Man charged with assault for pointing finger at police. Apparently it is now illegal, at least in the eyes of the corrupt police state, to even engage a police officer in any way other than complete subservience and groveling. PrisonPlanet.com, recounting the story as it was told by ABC 7 in Fredericksburg, Virginia, explains that David Loveless, a father with no ... MORE
Labels: crime, individual liberty, justice, law enforcement, police state, punishment, tyranny
John Stossel: Let's Give The Fed Some Competition
Pssst. Want to buy some Stossels? They're my own currency with my face on them. Why should you trust them? Because I promise to redeem them for gold. And I'm reliable. I have money in the bank and a job that brings in more than I spend. By contrast, the politicians who back American currency run an unsustainable deficit. The Federal Reserve prints so much ... MORE
Labels: competition, currency, economics, gold, government, inflation, monetary, money, monopoly
John W. Whitehead: Strip-Searching America
Strip-searches now allowed for minor traffic offenses. In a devastating 5-4 ruling that not only condones an overreach of state power but legitimizes what is essentially state-sponsored humiliation and visual rape, the U.S. Supreme Court recently declared that any person who is arrested and processed at a jail house, regardless of the severity of his or her ... MORE
Labels: individual liberty, law enforcement, police state, privacy, rights, Supreme Court, tyranny
Charles L. Hooper: They Really Don't Know Clouds At All
A dark cloud is forming over climate warming models. "I've looked at clouds from both sides now, From up and down, and still somehow, It's cloud illusions I recall, I really don't know clouds at all." —Singer Joni Mitchell. Science has an air of authority. Many people, including many scientists, have the view that all the important things are ... MORE
Labels: climate, environment, global warming, government, information, knowledge, science
Adam J. White: Flunking Constitutional Law
Constitutional ignorance of presidential proportions. Last week, President Obama clumsily announced that it would be "unprecedented" for the Supreme Court to strike down "a law that was passed by a strong majority of a democratically elected Congress." This week, his words are already having an effect in the courts—but not the effect he hoped for. ... MORE
Labels: Commerce Clause, Constitution, FDR, justice, law, ObamaCare, ruling, Supreme Court
Alicia M. Cohn: Ron Paul Demonstrates True Transparency
The rare politician who honors the public's trust. Ron Paul's presidential campaign regularly reports expenses well below the $200 minimum to the Federal Election Commission (FEC), and in at least 160 reports so far in the campaign has reported purchases costing a dollar or less. Paul's diligence goes beyond the letter of the law and is ... MORE
Labels: campaign, donations, election, FEC, integrity, politicians, Ron Paul, spending, transparency
Steve Chapman: Religion & Politics: An Unholy Alliance
The GOP may be shrinking its appeal. One day, in a sardonic jibe at some conservative who was piously claiming the mantle of heaven, I told my wife, "Don't forget, God's a Republican." Without missing a beat, she replied, "But his son's a Democrat." Between the Old Testament Jehovah and the New Testament Jesus, a Christian can find support for almost any ... MORE
Labels: Catholic, church, conservative, foreign policy, GOP, libertarian, politics, religion, Republican
Eliza Krigman: U.N. Seeks Power For Internet Regulation
What will be America's response to Russia and China? Faced with the prospect of United Nations regulation of the Internet, the United States has yet to appoint a leader for an upcoming battle with other countries over Web management. Less than a year from a historic treaty negotiation that will redefine international agreements on Internet management, the ... MORE
Labels: censorship, China, international, Internet, power, regulation, Russia, United Nations
VIDEO: Obama Campaign Makes Fraudulent Donations Easy
Accepts credit cards without requiring pesky validating information.
Labels: campaign, donations, election, fundraising, Mitt Romney, news, Obama, politics, security
Barry Farber: The Meddler In A Nursing Home
None of this is literally true; only in the important sense. A non-violent sadist loved to mess up people's heads in nursing homes. He learned of one where he could score double-demolition with one visit. His two favorite targets resided on neighboring floors. First, he visited the retired World War II veterans, tired old men in their late 80s and mid-90s ... MORE
Alan Reynolds: Minimum Wage, Maximum Damage
Kicking unemployment up another notch. President George W. Bush signed a bill in May 2007 that would eventually increase the federal minimum wage substantially but gradually, with the last hike in the summer of 2009 after he left office. National unemployment then was only 4.4 percent, and 22 states already had a higher minimum. So, the damage was not felt ... MORE
Labels: economics, income, jobless, minimum wage, politics, regulation, unemployment, workers
David Harsanyi: Obama And The Mother Of All Tyrannies
Who should be petrified of democracy? Anyone who's had a casual conversation with his neighbors or is cognizant of reality TV should already be petrified of democracy. But if the Supreme Court—or, as Barack Obama likes to refer to them, an "unelected group of people"—overturns Obamacare's individual mandate, the president says that the court would be ... MORE
Labels: Constitution, court, democracy, federal, government, justice, law, ObamaCare, politicians
Mario Loyola: The EPA Abuses First, Apologizes Later
The state's biggest bully beats up another victim. Last summer, I wrote about the Environmental Protection Agency's shameful persecution of a Texas natural-gas company, Range Resources Corp. The year before, EPA had slapped the company with an "emergency order" under the Safe Drinking Water Act, alleging that it "caused or contributed to" ... MORE
Labels: bureaucracy, environment, EPA, force, government, green, justice, law, regulation, tyranny
Nat Hentoff: Obama's NSA Close To Knowing All About Us
Do politicians know what country they are in? Not long before Dick Armey – a conservative Republican constitutionalist – retired as House majority leader, he gave a speech expressing his worry about the government's increasing blanket surveillance over We the People. He practically begged President George W. Bush to "use these tools we ... MORE
Labels: government, information, law enforcement, NSA, Obama, privacy, snooping, spying, surveillance
Daniel Allott: The Hate Crimes Farce
The threshold for a hate crime continues to decline. Have you ever used a racial slur? You may have two answers to that question. There's your initial visceral response: No! Of course not! Never! But then there's the response you'd give if you were being a little more honest: maybe... once or twice. So, if you have, does it make you a racist? In the court of ... MORE
Labels: Democrats, gay rights, hate speech, justice, lawyers, liberalism, political correctness, race
VIDEO: John Stossel - Camera Shy Or A Power High?
Some public servants don't want their service to be public.
Labels: arrest, citizens, government, individual liberty, law, monitor, regulation, rights
Thomas Sowell: The Invincible Dogma
How the government demonstrates discrimination. A long-standing legal charade was played out again recently, when Federal Express paid $3 million to settle an employment discrimination case brought by the U.S. Department of Labor. Federal Express was accused of both racial discrimination and sex discrimination. FedEx denied it. Why then did ... MORE
Labels: bureaucracy, collectivism, discrimination, gender, lawsuit, quotas, race, sex, statistics
Robin Zubrin: Carbon Emissions Are Good
Always check your premises. Last week, the Environmental Protection Agency (EPA) announced its intention to enforce regulations that would effectively ban new coal-fired power plants in the United States. As coal is by far America's cheapest and most plentiful fossil fuel, and coal-fired power stations account for 45 percent of all electricity generated ... MORE
Labels: climate, coal, electricity, energy, environment, EPA, global warming, regulation, science
Katie Pavlich: Unions Plan To Train 100,000 Protestors
Welcome to Occupy Spring. When The 99% Spring was announced in February, organizers vowed to train 100,000 people. It looks like they'll easily make that goal when their training programs kick off next week. There are already 918 planned around the country. All the group needs is about 10 people at each session to meet its goal, and ... MORE
Labels: choice, liberalism, Occupy Wall Street, philosophy, protesters, students, unions
Michael Barone: The Constitution's Comeback
Americans are worrying about the founding document again. I don't worry about the Constitution," said Representative Phil Hare, Democrat of Illinois, at a town-hall meeting where voters questioned his support of the legislation that became Obamacare. You can find the clip on YouTube, where it has 462,084 hits. That was before the 2010 election ... MORE
Labels: Congress, Constitution, election, FDR, guns, justice, law, ObamaCare, politicians, Supreme Court
Walter E Williams: Dupes For The State
The tragedy: an increased willingness to use government force. Public misunderstanding, ignorance and possibly contempt for liberty play into the hands of people who want to control our lives. Responses to my recent column "Compliant Americans" brought this home to me. In it, I argued that the anti-tobacco movement became the template and ... MORE
Labels: individual liberty, insurance, property rights, regulation, safety, smoking, tobacco
Americans Want MORE Control Of Their Own Health Care
by Shikha Dalmia. With the three-day ObamaCare circus at the Supreme Court behind us, let's fast-forward to June. Suppose that five justices find their constitutional bearings and do what a majority of Americans want them to do: Scrap the individual mandate, the key provision without which the law will collapse. What then? Will that mean that our current system ... MORE
Labels: control, government, health care, insurance, mandates, medical, ObamaCare, regulation
VIDEO: Smart Meters To Monitor A Nation Of Sheep
We are now electromagnetic radiation guinea pigs.
Labels: database, government, punishment, smart meters, snooping, spying, surveillance, tax
Rekha Basu: The Bigger Problem: Drugs Or Drug War?
Vincente Fox says the solution is legalization. When a former Mexican president comes to town, you might expect drugs to be discussed. You might not expect a pitch for legalizing them. But there on Wednesday was Vicente Fox, who led Mexico from 2000 to 2006, sharing a cocktail with a group at the Des Moines condo of Connie Wimer and Frank Fogarty ... MORE
Labels: crime, drug war, government, law enforcement, legalize, marijuana, politics, society, violence
Adam Liptak: Justices Approve Strip-Searches For Anything
No good reason required. The Supreme Court on Monday ruled by a 5-to-4 vote that officials may strip-search people arrested for any offense, however minor, before admitting them to jails even if the officials have no reason to suspect the presence of contraband. Justice Anthony M. Kennedy, joined by the court's conservative wing, wrote that courts are in no ... MORE
Labels: justice, law enforcement, police state, prison, privacy, search and seizure, Supreme Court
Sean Murphy: Lawmakers Look To Expand Gun Rights
You only get one chance at self-defense. The high-profile shooting death of an unarmed Florida teenager by a neighborhood watch captain has prompted rallies and protests across the country, including in Oklahoma, but state leaders say it won't affect the push for greater gun rights in Oklahoma. While officials in some states, like Florida, are taking a ... MORE
Emily Miller: America's High Tax Leadership
Highest corporate tax in the developed world. The United States is now, officially, the worst place to do business in the developed world. On Sunday, Japan lowered its corporate tax rate in the hopes of luring business to its shores, handing the title of highest tax rate to the Land of the Free. The market reaction on Monday will tell whether money will begin flowing ... MORE
Labels: business, competition, federal, government, industry, jobs, politics, revenue, tax, trade
Andrew C. McCarthy: Statism Goes To Court
Health care should not be a federal concern at all. Well, I can't imagine that that — that the Commerce Clause would — would forbid Congress from taking into account this deeply embedded social norm." This was Solicitor General Donald Verrilli on Day Two of the great Obamacare case. At issue was Affordable Care Act's most controversial aspect: ... MORE
Labels: Commerce Clause, insurance, mandates, medical, ObamaCare, regulation, Supreme Court
Sheldon Richman: How To Think LIke The Ruling Class
Understanding the origins of state power. In the beginning ruling classes had a problem. It will be familiar to those acquainted with the Austrian critique of central economic planning: Rulers could not know what they needed to know to do the job they wanted to do. Societies, even seemingly primitive ones, are complex networks held together by ... MORE
Labels: central planning, government, law, leaders, liberalism, ruling, society, statism, tyranny
Andrew Napolitano: The Real Question About ObamaCare
Can the government force you to eat broccoli? This week, the Supreme Court measured Obamacare to see whether it fits within the confines of the Constitution. The big picture is whether the Constitution limits the behavior of the federal government to the plain meaning and historical context of the Constitution, or whether clever lawyers and politicians ... MORE
Labels: Commerce Clause, crony capitalism, federal, government, justice, ObamaCare, Supreme Court
Matt Patterson: Obama Kills Coal - As Promised
Higher electricity prices will affect the poor most. "If someone wants to build a new coal-fired power plant they can, but it will bankrupt them because they will be charged a huge sum for all the greenhouse gas that's being emitted."- Candidate Barack Obama, 2008. Well, we can't say we weren't warned. This week, the unelected, unaccountable ... MORE
Labels: coal, electricity, energy, EPA, government, industry, Obama, regulation, technology
Dr. Mark Siegel: Individual Mandate Isn't The Worst Part
Doctors, patients, and the future of ObamaCare. Imagine if the government mandated that you buy an expensive certificate to eat at a certain restaurant chain, but you quickly discovered that this chain only provided you with limited food options and didn't hire additional chefs or waiters to cover the new volume of customers. Moreover, what if ... MORE
Labels: customer, government, health care, insurance, mandates, medical, ObamaCare, regulation
Alex Dobuzinskis: Branson Calls To End The Drug War
The billionaire adventurist advocates liberty. Virgin Group founder Richard Branson, involved in such ventures as selling space travel to the affluent, is now pushing for people to have the freedom to get high here on Earth without risking going to jail. The British billionaire argues criminal punishment fails to stem drug abuse, and is calling on countries ... MORE
Labels: crime, drug war, entrepreneur, government, individual liberty, law, legalize, marijuana, prison
William Ward: The Unseen Message Of The Hunger Games
Sparking a thirst for liberty? Though the liberal media and leftist Hollywood are wrapping themselves in The Hunger Games, the book series' pro-individualism, anti-socialist/communist/totalitarianism message has thus far eluded them -- but the legions of children reading the books are getting the message. When I learned that my teenage sons -- macho young lads ... MORE
Labels: capitalism, communism, culture, liberty, movie, production, regulation, socialism, tyranny
Shikha Dalmia: Forget About Income Inequality
It's economic opportunities that will help the poor. Reading David Grusky's essay is a strange experience: with the wrong diagnosis, he gets half of the right cure. Grusky maintains that the central problem confronting America is income inequality. He argues that the root cause of this malady lies in how rich people acquire their pre-tax income—by rigging the ... MORE
Labels: capitalism, economics, equality, free market, income, opportunity, prosperity, rich, rules, tax
S.F. GATE: Cops Pose As Bunnies To Write Seat Belt Tickets
And you thought bunnies were not in the rodent family? Officers in West Palm Beach, Fla., have come up with a diabolical new use for a giant bunny costume. According to the Palm Beach Post, a cop dressed in the costume Wednesday stood in a median with a sign that read "Have a safe, hoppy holiday. Buckle up!" While bemused motorists waved ... MORE & VIDEO
Labels: ethics, fines, force, government, law enforcement, police, punishment, regulation, revenue
Jacob Laksin: Obama's World Bank Pick Hates Capitalism
The president shows his true colors. Imagine if President Obama appointed radical Noam Chomsky, who has denounced capitalism as a "murderously destructive catastrophe," to head up a committee on economic growth. That's less of a stretch than it may seem, considering Obama's nominee to head the World Bank, current Dartmouth College ... MORE
Labels: banking, capitalism, economics, income, international, Obama, politics, World Bank
Steve Chapman: Toward The Conquest Of World Poverty
Even communist eventually have to make peace with reality. Progress can often be defined as the stuff that happens while humanity is preoccupied with everything that is going wrong. On the surface, the first decade of the 21st century looks like an ugly parade of terrorism, war and economic convulsion. But in one important sense it stands as ... MORE
Labels: economics, growth, international, poverty, prosperity, statistics, trade, wealth, welfare
Steven Greenhut: Californians Love Taxes
But they don't like government reform. A funny thing happened after California officials announced the shutdown of 70 state parks in the face of an estimated $33 million in budget cutbacks: Private companies, wealthy donors, nonprofit organizations and local governments came up with ways to keep many parks open. Eleven parks have already been ... MORE
Labels: California, debt, government, politics, prison, reform, services, spending, tax, unions
George F. Will: Economic Liberty Needs Protection
Using regulations as a weapon. Ali Bokhari, now 39, emigrated from Pakistan in 2000 and eventually settled in Nashville, Tenn., as a taxi driver, and soon experienced a quintessentially American itch, a nagging sense that "I cannot grow." But he had an idea: "I can build a better business model for something Nashville has been missing." He built it, and now knows ... MORE
Labels: business, economics, entrepreneur, government, individual liberty, justice, politics, regulation
John Stossel: Big Government Makes Us Small
Know-it-all politicians are job killers. Politicians say they "create jobs." In fact, only the private sector generates the information needed to create real, productive jobs. Since this current post-recession job recovery is the slowest in 80 years, you'd think that even know-it-all politicians would want to sweep away the labyrinth of government regulations that ... MORE
Labels: business, DOE, free enterprise, freedom, government, jobs, Obama, regulation, rules
Subscribe to: Posts (Atom)


text:
Publication Name: Press Telegram
Location: Long Beach, California
Pages Available: 335,414
Years Available: 1950 - 2007Learn More About This Publication
Press-Telegram (Newspaper) - May 4, 1959, Long Beach, California THEFT OF MILLIONS BARED BY SUICIDE PROMOTION CAUSED DOWNFALL OF L. B. BANKER Success spelled disaster for up-and-coming youpg banker The George A. Hewlett, whose suicide Saturday revealed an embezzlement in- volving millions of' dollars, Press-Telegram learned exclusively today. Hewlett, 40, had been cashier of Long Beach Na- JOHN R. HENDR1CKSON Named in Hewlett Note Find Girl's Body in River; Clue to Lost Family VANCOUVER, Wash. body of a little girl, found bobbing in the swift current of a Columbia River slough, provided a probable solution today to thy the federal government. The esti mate was. made by Assistant U. S. Ally. .Donald S.' Con- sting, at a hearing before a ederal .commission Sunday Francisco. that- Hen- drickson's bail be set at an unprecedented ha If-million dollars. An FBI4agent test! fled the manufacturer, who with his wife and seven chil dren lives in a home t San Rafael, "owns orJhas access" to a private airplane. U.S. Commissioner Joseph Karesh set bail at in'd'said.he...would'reduce it 'urther unless the govern ment .comes lip with new evi- dence by a.m. Tuesday. The 'case was continued until Hewlett's .body 'was .found on an.'Army blanket in a va- cant-lot 'at 2560 'Cedar Ave. Saturday. He was clutching a .38 caliber automatic pistol He was last reported seen alive Friday .night at Mag nolia Theatre, where he anc his wife were attending a performance of "The Cruel- tie." Hewlett slipped away 'rom- the' theater. i .It) a note, addressed to his wife, .Esther, Hewlett wrote: No one else is- in- volved in this horrible mess, or even has the slightest tnowledge'of, Johnnie Hendrickson. We i have not used this ourselves. It has all gone to John The note was written on the back of a blank check. A second note was .i'ound in Hewlett's home. In it, Hew- lett reportedly set the total of the ''erhberzlement at' FBI refused; to', dl-'. vulge consents of the note.' Hendrickson. 'jtold i a re-, porter in San, Fjrancisco: know wh'atf.these, charges are all 1' not be they are n6w j .-Hendrickson's hassbranches jn 'Los manufactures gas heaters and-.other, ances. i Funeral. services for lett'will be at 2 p.m. Tues- day at Mottell's Peek Mor tuary. toss Block invoy's Try Leap Out Hospital Window Fails; Aid Rushed From Burma RANGOON, Burma Soviet military attache who apparently had tried to escape ty leaping" from a hospital window was flown out ol Rangoon. on a Communisl slane Sunday. A screen of'40 hefty Rus sians from the Soviet Em jassy roughed up newsmen arjd prevented them from questioning him: Sources at the hospital sait the attache, was Col. Mikhai I. Stryguine, who-apparently wanted to get political asylum in Burma.- _The embass neither confirmed nor deniet published reports of his identity. The slightly built, haggard looking man was brought tc the airport in a Soviet Em bassy car minutes -before a Communist transpor plane took' off for Kunmini and Peiping. He was hustleet the votes. This is becaus he amendment specificall (Continued on Pg. A-4, Col. 3 Two Airmen Killed in Trainer Crash EUSTIS, Fla. Ai Force ROTC instructors from Oklahoma died Sunday whe their T33. jet trainer crashec and exloded near Lake J< hanria two miles from Eusti; Hurtling pieces of wrecl age from the two-place era smashed into two homes i the lakeshore housing deve opment as children playin nearby dashed for safety. Th victims were Maj. Jack L Slatton and CapL Willis L. Button. idal Wave Alert Sounds n Honolulu Warning Canceled After Hour; Set Off by Earthquake HONOLULU UPI Aitidal rave alert was sounded in the Hawaiian Islands today as the esult of a strong earthquake orth of Japan, but it was1 ailed off an hour and 35 min-: ites later. The alert had sent-.Ha-' waiians fleeing to higher, [round. Dr. Don Tocher, seismolo- gist'at the University of Calk ornia. at said the uake occurred miles' rpm fBerkeley, probably near ie- Kamchatka Veninsula in :iberia.v SEISMOGRAPHS through- Jut Japan also recorded the uake and a seismologist at h e Central Meteorological Jtation in Tokyo said he be-, ievedrit was strong enough o produce a tidal wave- Dr. Tocher said previous [uakes in the Kamchatka area iad sent tidal waves across he Pacific to Hawaii. 'He noted that one in 1952 caused ome damage at Midway, about a thousand miles closer o the quake center. The size of such a wave, he added, would depend on con-; ditions other than merely, the strength of the quake. THE LAST major tidal wave struck the Hawaiian is- ands in March of 1957, caus-1 ng widespread damage but no .direct casualties. The biggest tidal wave in recent history struck the is-' ands April 1, 1946. Mam- moth waves traveling 500 miles per hour struck Kauai irst, then Oahu and then the sla'nd of Hawaii. The waves killed 159 persons and seri- ously injured 163 others. Tornadoes Forecast in Midwest Areas KANSAS'CITY The Weather Bureau .said isolated tornadoes are expected in por- tions of southern Nebraska, central and western Kansas and the Panhandle and north- west portions of Oklahoma from late today. WHERE TO FIND IT: Because of another engagei ment, former President Tru- man has regretfully declined an invitation from President Eisenhower to attend a stag dinner honoring Sir Winston Churchill. See Page A-3. Beach B-I. Hal A-I5. A-15. C-3 to 8. B-6, 7. A-8. Death B-2. A-14. B-3, Shipping A-10, C-I, 2, 3, A-12. Tides, TV, B-8. Vital A-15. Woiaea B-4, I. ;

subset: commoncrawl


text:
Your language
Contact us +39 080 4859148
Forgot your password? Please Login
La nuova password è stata inviata al tuo indirizzo email
You are here: / Clothing Man / Borrelli / Shirts /
View More: Shirts
Authorized Dealer
Secure payment
Telephonic order
Free cash on delivery
Pick up In Store
Borrelli Shirts
100.00 (Tax free: € 81.97 )
1 Select a size
- See Table of Sizes
- Notify when returns available. Request
- Need help? Contact the Personal Shopper
- Quick Phone Order? +39 080 48 59 148
- White
- Azure
add to cart
Code MASSABOUTIQUE: 44879
Code BORRELLI: EV085000PT1/10
A classic white shirt is an essential in every man's wardrobe, whether it's for special occasions or an indispensable part of his workwear.Simple but professional, a premium shirt like this one from Borrelli, offers a tailored fit that ensures a smart and sophisticated finish.
Wear this effortlessly stylish cotton garment with a sharp suit and tie.
- Classic collar
- Nacreous buttons
- Tone-on-tone stitchings
- Cotton: 100%;
Code MASSABOUTIQUE: 44879 - Questions? Contact us
To view the size chart click here
- Collo misura 39 cm
- Spalla 44 cmm
- Torace 56 cm
- Vita 49 cm
- Lunghezza totale 78,5 cm
- Manica esterna 67 cm
- Manica interna 54 cm
- Vestibilità regolare
- Due pences dietro
Code MASSABOUTIQUE: 44879 - Questions?
Orders whose value exceed 250 EUR in only one transaction are shipped free of charge in EU countries.In non-EU countries orders whose value exceed 500 EUR in only one transaction are shipped free of charge.


text:
More Videos...
'70 Camaro SS Unload
'70 Camaro SS unloaded from Reliable truck from the Mecum auto auction
INSANE Street Race Papas Talon vs 417 SBC 69 Nova , 01 Bullitt vs 99 Camaro
one of the most exciting street race yet , views from every angle possible so you wont miss a thing . one of the best races for the Bullitt to this date .
Nova Vs. Malibu
Two VERY fast cars. BFE of course.
Subaru vs. Mitsubishi Minions Style
Subaru wins.


text:
The development of obesity. Insulin resistance, and metabolic syndrome Involves dysfunction of multiple organ systems and occurs In a complex and progressive fashion. In the initial funding cycle, small animal metabolic phenotyping was used to establish that two of the botanical extracts under study at our Center and (i.e. artemlsia dracunulus L., Incarnatin) ameliorated the developmental pathology ofthis process. More Importantly, this experimental strategy provided key insights regarding the tissue sites where beneficial effects were realized. The evolution of our experimental approach in the next cycle involves combining small animal metabolic phenotyping with the analytical power of metabolomic profiling to obtain the biochemical phenotypes that will provide insights Into the pathogenesis of Insulin resistance, and the mechanisms engaged by botanical extracts to ameliorate the progression. The Integrative Biology Core will combine state-of-the-art in vivo metabolic phenotyping with detailed ex vivo proteomic and metabolomic profiling of serum and tissue samples to provide highly Integrated metabolic signatures of the pathophysiology of insulin resistance and its resolution by botanical extracts. The Integrative Biology Core will be located at the Pennington and will be comprised of 2 interactive components: the Animal Research Subcore and the Analytical Chemistry Subcore, comprised of a Clinical Chemistry/Stable Isotope component and a Proteomic/Metabolomic component. The Integrative Biology Core will function Interactively with the Project leaders, the Administrative Core and the Botanical Core in all phases of experimental planning, execution, analysis, and interpretation. The overall goal of the IBC is to bring the combined expertise of all elements of the Botanical Research Center to bear upon our collective efforts to provide novel insights Into these mechanisms. We will use rodent models of obesity/diabetes to evaluate the mechanism of botanical extracts to ameliorate the development of this pathology, conducting detailed in vivo metabolic phenotyping to establish efficacy and guide timing of tissue harvest for rigorous ex vivo metabolomic profiling. The resulting biochemical signatures will be used to gain Insights Into the mechanism of action of botanical extracts.
The ability to obtain metabolic snapshots of substrate fluxes through metabolic pathways that integrate carbohydrate and lipid metabolism affords us an exciting opportunity to gain new molecular and physiologic insights Into the successful resolution of pathogenic mechanisms by our selected botanicals.
|Malina, Andrew; Bryant, Sherrisse K; Chang, Simon H et al. (2014) Capillary electrophoresis-based assay of phosphofructokinase-1. Anal Biochem 447:1-5
|Cheng, Diana M; Pogrebnyak, Natalia; Kuhn, Peter et al. (2014) Development and phytochemical characterization of high polyphenol red lettuce with anti-diabetic properties. PLoS One 9:e91571
|Cefalu, William T (2014) Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition. J Clin Invest 124:485-7
|Graf, Brittany L; Poulev, Alexander; Kuhn, Peter et al. (2014) Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties. Food Chem 163:178-85
|Cheng, Diana M; Pogrebnyak, Natalia; Kuhn, Peter et al. (2014) Polyphenol-rich Rutgers Scarlet Lettuce improves glucose metabolism and liver lipid accumulation in diet-induced obese C57BL/6 mice. Nutrition 30:S52-8
|Boudreau, Anik; Cheng, Diana M; Ruiz, Carmen et al. (2014) Screening native botanicals for bioactivity: an interdisciplinary approach. Nutrition 30:S11-6
|Ribnicky, David M; Roopchand, Diana E; Poulev, Alexander et al. (2014) Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice. Nutrition 30:S4-10
|Vance, Katie M; Ribnicky, David M; Rogers, Richard C et al. (2014) Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract. Neurosci Lett 582:115-9
|Waterman, Carrie; Cheng, Diana M; Rojas-Silva, Patricio et al. (2014) Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry 103:114-22
|Henagan, Tara M; Lenard, Natalie R; Gettys, Thomas W et al. (2014) Dietary quercetin supplementation in mice increases skeletal muscle PGC1? expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS One 9:e89365
Showing the most recent 10 out of 98 publications


text:
Diagnostic value of anti-cyclic citrullinated peptides and association with HLA-DRB1 shared epitope alleles in African rheumatoid arthritis patients
DOI: 10.1186/ar2945
© Singwe-Ngandeu et al.; licensee BioMed Central Ltd. 2010
Received: 16 October 2009
Accepted: 02 March 2010
Published: 02 March 2010
The purpose of this study was to examine the diagnostic performance of autoantibodies against citrullinated peptides/proteins (ACPA) and to determine the prevalence of HLA-DRB1 shared epitope alleles (SE) in African patients with rheumatoid arthritis (RA).
Serum levels of anti-cyclic citrullinated peptides antibodies (anti-CCP2, anti-CCP3), IgM and IgA rheumatoid factors (RF) were measured by enzyme-linked immunosorbent assay in the serum of 56 consecutive RA patients regularly followed in the Rheumatology Unit of the School of Medicine, University of Yaoundé, Yaoundé, Cameroon. Genotyping of HLA-DRB1 alleles was performed by polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes on microbeads arrays. Fifty-one patients with other inflammatory rheumatic diseases and 50 healthy individuals were included as controls.
An anti-CCP2 assay showed the best diagnosis sensitivity (82%) and specificity (98%) with high positive predictive (PPV) (96%) and negative predictive values (NPV) (91%). Thirty percent of RA patients were carrying at least one copy of the HLA-DRB1 shared epitope (SE) compared to 10% and 14% of patients with other inflammatory rheumatic diseases and healthy individuals, respectively. The presence of the SE was associated with the production of ACPA.
Anti-CCP2 antibodies are useful markers of RA in African patients. In this cohort, the prevalence of the SE is higher in RA patients than in controls but lower than that reported in patient cohorts of European ancestry. The discrepancy between the high prevalence of ACPA-positive patients and the relatively low number of SE-positive cases suggest that, in addition to SE, other genetic factors control the development of ACPA in African RA patients.
Rheumatoid arthritis (RA) is characterized by inflammation of the synovial membrane of diarthrodial joints leading to tissue destruction and severe disability. The cause of RA is unknown but genetic susceptibility and environmental factors appear to be involved. RA is the most frequent systemic autoimmune inflammatory disease with a prevalence of approximately 0.5 to 1% in populations of European ancestry. However, it appears to have a relatively lower prevalence among African populations, particularly those living in rural settings [1–3].
Two important autoantibody systems have been described in RA, including rheumatoid factors (RF) directed to the Fc fragment of IgG and autoantibodies against citrullinated peptides/proteins (ACPA). RFs are well-known autoantibodies associated with RA and are present in approximately 70 to 80% of RA patients, but because they are also detected in patients with other autoimmune diseases as well as in chronic infections and in lymphoma or other tumoral processes, they have limited specificity. ACPA such as anti-cyclic citrullinated peptides (anti-CCP) are directed to antigens that contain arginyl converted to citrullyl residues by peptidylarginyl deiminase enzymes [4, 5]. Several studies have shown that these antibodies are present in 60% to 80% of Caucasian RA patients with a high specificity of more than 95% [6]. However, there are no data regarding the presence of these antibodies in African patients with RA.
The genetic component of RA has been determined with heritability estimates of 50% to 60% [7]. The major susceptibility loci associated with susceptibility to RA were identified approximately 30 years ago and consist of the human leukocyte antigen (HLA) class II molecules. There is extensive evidence that some HLA-DRB1 alleles, including HLA-DRB1*0101, HLA-DRB1*0102, HLA-DRB1*0401, HLA-DRB1*0404, HLA-DRB1*0405, HLA-DRB1*0408, HLA-DRB1*0410, HLA-DRB1*1001, HLA-DRB1*1402 are associated with susceptibility to RA. These alleles share a common amino acid sequence (QKRAA, QRRAA, or RRRAA), also termed shared epitope (SE), located at positions 70 to 74 within the third hypervariable region of DRB1, forming part of the antigen-binding site. The shared epitope accounts for at least 30% of the total genetic susceptibility [8]. In addition, the associations between the SE and other genetic markers including PTPN22, CTLA4, CD40 genes, the TRAF1/C5 region and SNPs between OLIG3 and TNFAIP3 genes, and anti-CCP positivity have been reported in different populations (reviewed in [9]).
The objective of this study was to examine the prevalence of ACPA detected by anti-CCP2 and anti-CCP3 enzyme-linked immunosorbent assays (ELISAs), and that of HLA-DRB1 alleles in African RA patients in order to examine first the diagnostic performance of these serological tests as compared to RF, and then the distribution of the SE alleles and their association with ACPA.
Materials and methods
This study was carried out on 56 RA patients recruited consecutively from the outpatient Rheumatology Clinic of Yaoundé Central Hospital in Cameroon. These RA patients fulfilled the American College of Rheumatology 1987 criteria for RA [10]. Fifty-one patients (20 females) with other rheumatic conditions and ages ranging from 16 to 65 (median 28), and 50 healthy individuals (33 females) with ages ranging from 22 to 55 (median 34) were included as controls. Patients with other inflammatory rheumatic conditions were consecutively recruited from the same outpatient clinic, while healthy controls were recruited among medical students and hospital workers in Yaoundé. Patients with RA were treated with disease modifying antirheumatic drugs (DMARDs), including methotrexate, hydroxychloroquine, sulphasalazine, leflunomide, combinations of methotrexate, hydroxychloroqine and sulphasalazine and/or oral prednisone. RA patients were assessed for demographic characteristics, disease duration, duration of morning stiffness, pain by visual analogue scale, number of tender joints, number of swollen joints, the presence or absence of nodules, extra-articular manifestations, and co-morbidities. The disease activity score (DAS28) was calculated as previously described [11]. Hand radiographs were obtained for each RA patient. Approval of the Cameroon National Ethical Committee was obtained prior to the study and an informed consent was obtained from all patients and controls included in this study.
IgM and IgA RF determinations by enzyme immunoassays
Commercially available ELISA kits, purchased from Inova Diagnostics (Ruwag, Zurich, Switzerland), were used to detect IgM and IgA RF. The assays and calculations were performed according to the manufacturer's instruction. Each kit included its own RF standard and the results were calculated as arbitrary units/ml. The diagnostic performance of these kits has been previously evaluated in a Swiss population of RA patients and controls [12].
Anti-cyclic Citrullinated Peptide antibody determination by enzyme immunoassay
The ELISA kits detecting the IgG anti-CCP2 antibodies (Immunoscan RA: regular, second generation of CCP antigen), were purchased from Euro-Diagnostica (Pharma Consulting, Burgdorf, Switzerland), and those detecting the IgG anti-CCP3 (Quanta Lite CCP3: third generation of CCP antigen), were purchased from Inova Diagnostics (Ruwag, Zurich, Switzerland). The assays and calculations were performed according to the manufacturers' protocols. Each manufacturer uses its own anti-CCP calibrator and the results were calculated as arbitrary units/ml. In addition, to avoid false positive results for anti-CCP2 antibody determination, reactivity to non-citrullinated peptides containing arginyl instead of citrullyl residues was also tested. Diagnosis sensitivity and specificity of anti-CCP2 antibody determination have been previously determined in our laboratory in Swiss and in French patients with RA and in controls [13, 14]. The sensitivity and specificity of anti-CCP3 were compared to those of anti-CCP2 in two studies on different populations [15, 16].
HLA-DRB1 genotyping
Genomic DNA was extracted from 350 μl-aliquots of frozen blood samples by using the GenoM6 magnetic bead-based workstation. HLA-DRB1 generic typing was performed by PCR-SSOP (sequence-specific oligonucleotide probes) reverse hybridization using the Luminex technology after locus-specific exon 2 amplification. The method is based on fluorescent microbeads coated with oligonucleotide probes specific for the polymorphic positions of DRB1 exon 2 sequences (LabType RSSO2B HD, OneLambda). Automated reading (Labscan TM100, Luminex, Austin, Texas USA)) and interpretation led to HLA-DRB1 high resolution (four-digit) typing as previously described [17].
Statistical Analysis
Baseline characteristics of RA patients
Age (yrs)
53.5 (39 to 61.5)
Female sex (%)
Disease duration (yrs)
3 (2 to 6)
Erosions (%)
Subcutanous nodules (%)
4.72 (3.8 to 6.4)
Morning stiffness (minutes)
30 (10 to 60)
VAS-pain (0 to10)
5 (3 to 7)
CRP (mg/L)
12 (6 to 35)
Tobacco, N (%)
1 (2)
Prednisone, N (%)
51 (91)
Dose (mg/day)
Methotrexate, N (%)
43 (77)
Dose (mg/day)
Sulfasalazine, N (%)
7 (12)
Azathioprine, N (%)
2 (5)
Leflunomide, N (%)
2 (5)
D-penicillamine, N (%)
1 (2)
The diagnostic performances and cut offs of all the serological assays used in this study have been initially validated in Caucasians. Thus, we decided to identify the most discriminant cut-off values of the different tests for this particular population, which were operationally defined as the cut-off values leading to the highest percentage of correctly classified patients. The most discriminant cut-offs to be considered as positive were with values ≥ 22 units/ml for IgM RF, ≥ 1 unit/ml for IgA RF, ≥ 32 units/ml for anti-CCP2, ≥ 17 units/ml for anti-CCP3, respectively. Using these established cut-offs, we computed the sensitivity, the specificity, the positive predictive value (PPV) and the negative predictive value (NPV) of the various biologic tests in this population. We used the area under the curve (AUC) of the receiver operating curves (ROC) to compare the diagnostic performance of the various biologic tests in this population. Sensitivity and specificity were compared using the exact McNemar's probability test.
Finally, we examined the agreement or correlation between these biomarkers using a kappa statistic. We then examined which of these tests provided independent information for the diagnosis of RA. We first performed simple stratified analyses (patients stratified according to their genetic SE status) and then performed a multivariate logistic regression model, where the diagnosis of RA was the dependent variable and the various tests the independent variables. All statistical tests were two-sided and at the 0.05 significance level. The statistical analysis was performed with STATA v. 9.1.
This study included all the RA patients followed at the University Hospital outpatient clinic of Yaoundé, Cameroon. The clinical characteristics of these 56 patients are described in Table 1. Most of them were female with established disease (more than two years). All of them had either moderate or active disease according to DAS28 levels and 44% had radiographic signs of joint erosions on hand X-rays. Ninety-one percent of patients were on DMARDs and the vast majority of them were on methotrexate (77%). Seven out of 56 patients received a combination of DMARDs but none of them were on biologic therapy as these drugs are not available in Cameroon. Fifty-one control patients with inflammatory rheumatic diseases were recruited from the same outpatient clinic and had disease duration ranging from 1 to 10 years (median 3). The different diagnosis included 18 unclassified oligoarthritis (some cases with probable reactive arthritis), thirteen patients with ankylosing spondylitis, three psoriatic arthritis, nine systemic lupus erythematosus, three oligoarthritis in HIV-positive patients, three adult Still's disease, one systemic sclerosis, and one adult with juvenile idiopathic arthritis.
Serological and immunogenetic characteristics in RA patients, controls with inflammatory rheumatic diseases, and healthy individuals
Laboratory values
IRD (n = 56)
HI (n = 51)
Sensitivity (n = 50)
RF IgM (%)
3 (6)
4 (8)
0.85 (0.79 to 0.91)
RF IgA (%)
8 (16)
0 (0)
0.88 (0.82 to 0.94)
Anti-CCP2 (%)
1 (2)
1 (2)
0.90 (0.85 to 0.96)
Anti-CCP3 (%)
4 (8)
1 (2)
0.86 (0.80 to 0.92)
SE 1 or 2 copies (%)
7 (14)
5 (10)
0.59 (0.52 to 0.66)
- SE 1 copy (%)
7 (14)
5 (10)
0.57 (0.51 to 0.64)
- SE 2 copies (%)
0 (0)
0 (0)
0.52 (0.49 to 0.54)
Shared epitope related HLA-DR distribution in RA patients and controls
Role of the shared epitope as predictor of the presence of ACPA and RF in RA patients
SE (1 or 2 copies)
IgM RF
IgA RF
All the immunological tests were significantly correlated to each other and the agreement ranged between 70% and 90% (kappa test). In a multivariate logistic regression analysis, IgM RF, IgA RF, anti-CCP2, and anti-CCP3 were independently associated with RA, which suggests that all these autoantibodies provide complementary information for the diagnosis of RA.
Our study of African RA patients confirmed previous studies in patients of European ancestry showing that anti-CCP2 and anti-CCP3 antibodies exhibit high diagnostic specificity for RA with anti-CCP2 antibodies having the highest PPV and NPV. However, the number of patients and controls included in our study limits the interpretation of these results, and future studies including a larger number of individuals should be carried out in the African population to confirm these findings. Interestingly, a recent report including Dutch patients with undifferentiated arthritis and comparing anti-CCP2, anti-CCP3, anti-citrullinated vimentin, and RF showed that anti-CCP2 tended to achieve the highest PPV for RA development [19].
IgM RF is the only serological marker for RA currently available in Cameroon. The validation of the assay for the Cameroonese population led to a marked increase of cut-off values, as compared to those recommended by the vendor, in order to improve the specificity of the test. The presence of elevated background levels of IgM RF in African controls (16% of IgM RF-positive healthy controls when using the recommended cut-off values) is probably caused by non-specific activation of the immune system by different infectious and parasitic diseases. Interestingly, the results of ACPA tests, in particular anti-CCP2 positivity, were not influenced in a similar manner as IgM RF.
Only a few studies have been conducted to determine the association between HLA-DRB1 and RA in Africa. These studies included a limited number of patients and mainly referred to HLA-DR antigens detected by serological typing or by low resolution DNA typing. One study on Zimbabweans showed a higher prevalence of HLA-DR4 in RA patients, [20]. A study performed in Senegal showed that the relative risk (RR) of developing RA was significantly associated with HLA-DR10 (RR 32), but not HLA-DR4 (RR 0.8) [21]. The frequency of SE-containing HLA-DRB1 alleles was 25.2% in African Americans with RA as compared to 13.6% in healthy subjects. Thus, the SE was significantly associated with susceptibility to RA, but the percentage of SE positivity was globally lower than that reported in RA patients of European ancestry, which ranges between 50 to 70% [22, 23]. The frequency of HLA-DRB1*0401, 0404, 0405, and 1001 alleles were higher among African American RA patients than in healthy controls. Of note, a higher level of European admixture was associated with a higher likelihood of carrying the SE among African Americans. More specifically, HLA-DRB1*0401 but not the other alleles encoding the SE, was significantly associated with the presence of European ancestry [24]. In another study, HLA-DRB1*0102 and HLA-DRB1*0405 were significantly more frequent among African American RA than European RA patients with odds ratio (OR) of 8.66 and 2.75, respectively. HLA-DRB1*1001 tended also to be more frequent in African American RA than European RA patients (OR 2.11). In contrast, an opposite result was found regarding HLA-DRB1*0401 with an odds ratio of 0.15 [25]. Thus, our results as well as recent reports on African American patients indicate that, although the presence of the SE is associated with RA, its frequency is much lower than that observed in patients of European ancestry, with also a distinct SE allele profile characterized in particular by a lower HLA-DRB1*0401 frequency.
RA is a clinically heterogeneous disease and there has been some speculation recently that it may comprise at least two distinct subgroups characterized by the presence/absence of ACPA. For example, the carriage of the SE appears particularly confined to anti-CCP positive RA cases [26, 27]. In addition, a significant association between SE and the presence of anti-CCP2 antibodies was demonstrated in African American RA patients [24]. In our study, there was also an association between ACPA and SE. However, this association was relatively weak, probably due to the limited number of patients included in our study. The fact that ACPA are present in a similar percentage of African patients as previously reported in European patients despite a major difference in the proportion of SE-positive patients, suggests that other non-HLA genetic factors contribute to the development of RA and of these autoantibodies in African RA patients. Of note, an African specific allele of CTLA4 has recently been shown to confer protection against RA in African Americans [28].
Tobacco use was shown to be associated with the development of the disease, in particular in anti-CCP2-positive, SE-positive RA patients [26]. In one study, the conjunction of tobacco use and HLA-DRB1*0101 or *0102 was the strongest factor for the development of these antibodies [29]. With the exception of one case, none of our patients smoked, which is in line with general living habits of African women. This finding suggests that other environmental factor may be involved in the development of RA.
To our knowledge this study is the first report on combined HLA-DRB1 SE and ACPA status in an African patient cohort without known European admixture. It has, however, limitations due to the limited number of patients and controls included. In addition, the patient population is highly selected as we had only access to outpatients followed in a university hospital, representing patients from an urban setting with moderate to severe disease. However, the Rheumatology Unit is the only specialized center available for the population of Yaoundé and its suburbs and we reduce this bias by including all the RA patients attending the clinic without any further selection.
Our study showed that anti-CCP2 antibodies are sensitive and specific diagnostic markers of RA also in African patients. The discrepancy between the high prevalence of ACPA-positive patients and the relatively low number of SE-positive cases as well as the relative lack of tobacco smokers suggest that other genetic and environmental factors control the development of ACPA in African RA patients.
anti-citrullinated peptides/proteins antibodies
area under the curve
cyclic citrullinated peptides
- DMARDs:
disease modifying antirheumatic drugs
inflammatory rheumatic diseases
healthy individuals
positive predictive value
negative predictive value
rheumatoid arthritis
rheumatoid factor
receiver operating curve
relative risk
shared epitope.
We are grateful to S. Teyssier for his contribution to the HLA typing assays. CG is supported by a Swiss National Science Foundation grant (320000-119728).
Authors' Affiliations
- Beighton P, Solomon L, Valkenburg HA: Rheumatoid arthritis in a rural South African Negro population. Ann Rheum Dis. 1975, 34: 136-141. 10.1136/ard.34.2.136.PubMed CentralView ArticlePubMedGoogle Scholar
- Brighton SW, de la Harpe AL, van Staden DJ, Badenhorst JH, Myers OL: The prevalence of rheumatoid arthritis in a rural African population. J Rheumatol. 1988, 15: 405-408.PubMedGoogle Scholar
- Silman AJ, Ollier W, Holligan S, Birrell F, Adebajo A, Asuzu MC, Thomson W, Pepper L: Absence of rheumatoid arthritis in a rural Nigerian population. J Rheumatol. 1993, 20: 618-622.PubMedGoogle Scholar
- Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, Sebbag M, Vincent C, Simon M, Senshu T, Masson-Bessiere C, Jolivet-Reynaud C, Jolivet M, Serre G: The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol. 1999, 162: 585-594.PubMedGoogle Scholar
- Schellekens GA, de Jong BA, Hoogen van den FH, Putte van de LB, van Venrooij WJ: Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1998, 101: 273-281. 10.1172/JCI1316.PubMed CentralView ArticlePubMedGoogle Scholar
- Cruyssen Vander B, Nogueira L, Van Praet J, Deforce D, Elewaut D, Serre G, De Keyser F: Do all anti-citrullinated protein/peptide antibody tests measure the same? Evaluation of discrepancy between anti-citrullinated protein/peptide antibody tests in patients with and without rheumatoid arthritis. Ann Rheum Dis. 2008, 67: 542-546. 10.1136/ard.2007.071654.View ArticleGoogle Scholar
- MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ: Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 2000, 43: 30-37. 10.1002/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B.View ArticlePubMedGoogle Scholar
- Deighton CM, Walker DJ, Griffiths ID, Roberts DF: The contribution of HLA to rheumatoid arthritis. Clin Genet. 1989, 36: 178-182.View ArticlePubMedGoogle Scholar
- Klareskog L, Catrina AI, Paget S: Rheumatoid arthritis. Lancet. 2009, 373: 659-672. 10.1016/S0140-6736(09)60008-8.View ArticlePubMedGoogle Scholar
- Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. 10.1002/art.1780310302.View ArticlePubMedGoogle Scholar
- Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, Putte van de LB, van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995, 38: 44-48. 10.1002/art.1780380107.View ArticlePubMedGoogle Scholar
- Bas S, Perneger TV, Kunzle E, Vischer TL: Comparative study of different enzyme immunoassays for measurement of IgM and IgA rheumatoid factors. Ann Rheum Dis. 2002, 61: 505-510. 10.1136/ard.61.6.505.PubMed CentralView ArticlePubMedGoogle Scholar
- Bas S, Perneger TV, Seitz M, Tiercy JM, Roux-Lombard P, Guerne PA: Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors. Rheumatology (Oxford). 2002, 41: 809-814. 10.1093/rheumatology/41.7.809.View ArticleGoogle Scholar
- Bas S, Genevay S, Meyer O, Gabay C: Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis. Rheumatology (Oxford). 2003, 42: 677-680. 10.1093/rheumatology/keg184.View ArticleGoogle Scholar
- Lutteri L, Malaise M, Chapelle JP: Comparison of second- and third-generation anti-cyclic citrullinated peptide antibodies assays for detecting rheumatoid arthritis. Clin Chim Acta. 2007, 386: 76-81. 10.1016/j.cca.2007.08.002.View ArticlePubMedGoogle Scholar
- dos Anjos LM, Pereira IA, d 'Orsi E, Seaman AP, Burlingame RW, Morato EF: A comparative study of IgG second- and third-generation anti-cyclic citrullinated peptide (CCP) ELISAs and their combination with IgA third-generation CCP ELISA for the diagnosis of rheumatoid arthritis. Clin Rheumatol. 2009, 28: 153-158. 10.1007/s10067-008-0999-5.View ArticlePubMedGoogle Scholar
- Rahal M, Kervaire B, Villard J, Tiercy JM: DNA typing by microbead arrays and PCR-SSP: apparent false-negative or -positive hybridization or amplification signals disclose new HLA-B and -DRB1 alleles. Tissue Antigens. 2008, 71: 238-241. 10.1111/j.1399-0039.2007.00993.x.View ArticlePubMedGoogle Scholar
- Pimtanothai N, Hurley CK, Leke R, Klitz W, Johnson AH: HLA-DR and -DQ polymorphism in Cameroon. Tissue Antigens. 2001, 58: 1-8. 10.1034/j.1399-0039.2001.580101.x.View ArticlePubMedGoogle Scholar
- Linden van der MP, Woude van der D, Ioan-Facsinay A, Levarht EW, Stoeken-Rijsbergen G, Huizinga TW, Toes RE, Helm-van Mil van der AH: Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis. Arthritis Rheum. 2009, 60: 2232-2241. 10.1002/art.24716.View ArticlePubMedGoogle Scholar
- Martell RW, Stein M, Davis P, West G, Emmanuel J, du Toit ED: The association between HLA and rheumatoid arthritis in Zimbabwean blacks. Tissue Antigens. 1990, 36: 125-126. 10.1111/j.1399-0039.1990.tb01813.x.View ArticlePubMedGoogle Scholar
- Dieye A, Diallo S, Diatta M, Thiam A, Ndiaye R, Bao O, Sarthou JL: [Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal]. Dakar Med. 1997, 42: 111-113.PubMedGoogle Scholar
- Silman AJ, Pearson JE: Epidemiology and genetics of rheumatoid arthritis. Arthritis Res. 2002, 4 (Suppl 3): S265-272. 10.1186/ar578.PubMed CentralView ArticlePubMedGoogle Scholar
- Thomson W, Harrison B, Ollier B, Wiles N, Payton T, Barrett J, Symmons D, Silman A: Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based study. Arthritis Rheum. 1999, 42: 757-762. 10.1002/1529-0131(199904)42:4<757::AID-ANR20>3.0.CO;2-X.View ArticlePubMedGoogle Scholar
- Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO, Dwivedi H, Mikuls TR, Holers VM, Parrish LA, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, Moreland LW, Patterson N, Reich D, Bridges SL: The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. Arthritis Rheum. 2008, 58: 349-358. 10.1002/art.23166.PubMed CentralView ArticlePubMedGoogle Scholar
- Del Rincon I, Battafarano DF, Arroyo RA, Murphy FT, Fischbach M, Escalante A: Ethnic variation in the clinical manifestations of rheumatoid arthritis: role of HLA-DRB1 alleles. Arthritis Rheum. 2003, 49: 200-208. 10.1002/art.11000.View ArticlePubMedGoogle Scholar
- Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, Ronnelid J, Harris HE, Ulfgren AK, Rantapaa-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L: A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006, 54: 38-46. 10.1002/art.21575.View ArticlePubMedGoogle Scholar
- Helm-van Mil van der AH, Verpoort KN, Breedveld FC, Huizinga TW, Toes RE, de Vries RR: The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum. 2006, 54: 1117-1121. 10.1002/art.21739.View ArticlePubMedGoogle Scholar
- Kelley JM, Hughes LB, Faggard JD, Danila MI, Crawford MH, Edberg Y, Padilla MA, Tiwari HK, Westfall AO, Alarcon GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD, Allison DB, Kimberly RP, Moreland LW, Edberg JC, Bridges SL: An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans. PLoS Genet. 2009, 5: e1000424-10.1371/journal.pgen.1000424.PubMed CentralView ArticlePubMedGoogle Scholar
- Helm-van Mil van der AH, Verpoort KN, le Cessie S, Huizinga TW, de Vries RR, Toes RE: The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. Arthritis Rheum. 2007, 56: 425-432. 10.1002/art.22373.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Universal Fit
HiSoundAudio Wooduo 2
" This will not be the most professional review you'll read. I will offer my experience of only the sound and build quality of these IEMS from an average consumer's point of view. Just to give some reference, I'm currently rocking the Sony MDR-EX650AP as my daily earphones. For being earphones with balanced drivers at $60, they really have no weaknesses to speak of , which is..." --Bitsir
HiSoundAudio Popo
" I am always on the search for great in-ear headphones, however I always seem to find the same problem, because they are in ear, they tend to have very small drivers, meaning there is never much bass, and in most cases the highs are also messed up in an effort to get more bass! So I am always on the lookout for in-ear headphones that have good bass, yet have a nice flat frequency..." --MyConnor5Review
Hisoundaudio HA-2
" Preamble: HiSoundAudio (http://www.hisoundaudio.com/en/index.asp, not up to date) is a Chinese audio company, known for their in-ears and audio players. Besides their new DAP, they are also about to come out with a new in-ear model. Having talked to Jack from HiSoundAudio, he said that they are extremely confident about their upcoming single-BA in-ear which is..." --HiFiChris
Superlux HD 381
"Intro TL;DR: The Superlux HD381F is an IEM that pops tags with its exceptional sound quality in its cheap-looking and completely unassuming package. Before I begin, I would like to first thank George at Gearbest.com for providing a review sample of the Superlux HD381F in exchange for my honest opinion. I would like to clarify that I am neither affiliated with..." --thatBeatsguy
HiSoundAudio Living
"Foreword: I'm a production manager, but mainly focus on live sound engineering and lighting. I install and tune P.A equipment, and mix live acts in: - live venues, - concert halls, - bars, and - nightclubs. I've taken a huge liking to headphones - IEMs in particular. I like the idea of having my own personal PA system that I can take with me anywhere. With Rockbox being in such..." --White Lotus
HiSoundAudio Crystal
"Introducing HiSound Audio's Crystal IEMs After reviewing HSA's E212 and PAA-1Pro recently, Jack approached me and asked if I'd like a review sample of the Crystal (IEM) and Living (Earbuds). I jumped at the chance, and after paying for the freight - they duly arrived a couple of weeks ago. I've listed price at the RRP of ~ USD $69 – this is not what I paid for them..." --Brooko
HiSoundAudio Golden Crystal
"Hisoundaudio Golden Crystal First I'd like to thank Jack at Hisoundaudio for giving me the opportunity to purchase the Golden Crystals, or GC as I'll reference them, as they are not yet available from any US dealer. Meet the super tiny Golden Crystals. They are the smallest dynamic driver on the planet (I think the Monster Tributes are 5mm as well, if..." --shotgunshane
HiSoundAudio Popular
The introducing of Popular : Popular is a pair IEMs specially designed for the "modern style" music. Popular feature an impactful bass, upfront vocal and detailed highs. With the drum shape chamber design, it has exceptional bass reaction. It's bass is huge in quantity and high in quality. It's bass is clear and controlled. The mids are warm and layered with a slightly...


text:
Congratulations, John
Marilyn de Queiroz
Posts: 9079
posted 13 years ago
for earning your first moose.
"Yesterday is history, tomorrow is a mystery, and today is a gift; that's why they call it the present." Eleanor Roosevelt
Barry Gaunt
Ranch Hand
Posts: 7729
posted 13 years ago
Ask a Meaningful Question and HowToAskQuestionsOnJavaRanch
Yeah! Congrats!
Ask a Meaningful Question and HowToAskQuestionsOnJavaRanch
Getting someone to think and try something out is much more useful than just telling them the answer.
jason adam
Chicken Farmer ()
Ranch Hand
Ranch Hand
Posts: 1932
John Hembree
hired gun
Ranch Hand
Ranch Hand
Posts: 250


text:
Grilled Fish Cakes
|Cooked halibut
|425 Milliliter, boned and flaked (425 Milliliter)
|Mashed potatoes
|625 Milliliter (Hot, 2 1/2 Cups)
|Chopped parsley
|15 Milliliter (1 Tablespoon)
|Chopped cooked onions
|45 Milliliter (3 Tablespoon)
|Soft butter
|50 Milliliter (2 Tablespoon)
|Beaten egg
|250 Milliliter (1 Cup)
|Peanut oil
|45 Milliliter (3 Tablespoon)
|To Taste
|To Taste
Place fish, potatoes, parsley, onions, butter and beaten egg in food processor.
Season well and blend until well incorporated.
Shape mixture into small balls and flatten.
Dust lightly in flour.
Heat oil in large frying pan.
Add fish cakes without crowding and cook 2 to 3 minutes over medium-high heat.
Turn patties over once and adjust time depending on thickness.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 4432 Calories from Fat 926
% Daily Value*
Total Fat 105 g161.3%
Saturated Fat 37.4 g186.8%
Trans Fat 0 g
Cholesterol 637.7 mg212.6%
Sodium 1397.9 mg58.2%
Total Carbohydrates 716 g238.8%
Dietary Fiber 62.6 g250.5%
Sugars 3.4 g
Protein 182 g364.8%
Vitamin A 68.7% Vitamin C 443.6%
Calcium 23.7% Iron 83.3%
*Based on a 2000 Calorie diet


text:
Reviewed By: Janice
Posted: Tuesday, April 28, 2015
Location: Antioch, IL
Comments: I highly recommend this oil for sensitive skin. It does not have a strong scent and it really calms the skin and moisturizes deeply without irritation. It is thicker than other oils and takes a little longer to absorb, but is worth it!
Reviewed By: Shannon
Posted: Wednesday, March 19, 2014
Location: Yadkinville, NC
Comments: Thick, viscous oil and very nice.
"Thank you sooooo much! I just wanted to say that I LOVE your products and thank you for your excellent customer service!!! I especially love the superior products, the preferred customer program and the fact that you allow discounts for certain affiliations. This, as a small business owner, is very helpful to me."
- Lynn Turner | Pampering U, Inc., Baltimore, MD


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Dominique Devienne" <ddevie...@gmail.com>
|Re: path performance
|Wed, 18 Oct 2006 15:04:21 GMT
> Timing indicates that ant is spending 30 seconds per test to walk the lib > tree building the classpath. Does anyone have a solution to this problem? Frankly, that sounds a bit fishy ;-) Unless your hierarchy is exceedingly large in ${lib.dir}, it's unlikely it's the fileset scan that's taking so long. I'd write a build file that only defines the <fileset>, then <pathconvert>s it and <echo>s it, with timestamps around to find out for sure how long is the scan. Could be that you have fork="true" on JUnit, and the overhead of starting a new VM and/or the test infrastructure is to blame??? Is the scan really is that slow, then you could expand once all jars/zips in a single dir, and use that dir on the classpath (and/or create an uber-jar of this dir). a LOT of JARs is too vague I guess. Do the self-contained timing test above, and give us some more indication as to what LOT means in this case. --DD --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: firstname.lastname@example.com
|View raw message


text:
UMC Event Calendar
W.O.W. - Comedy Hypnotist Eric Mina
Wednesday, September 17, 2014
What's on Wednesday? Comedy Hypnotist Eric Mina
7 p.m., Kiehle Auditorium
It was the great inventor Henry Ford who said, "Whether you think you can, or you think you can't, you're right." This quote has inspired Eric Mina to follow his dreams. It was this dream that led Eric to pursue a Bachelors in Psychology from Penn State University and certification as a hypnotherapist. Whether it's playing mind tricks in Australia, reading thoughts in Las Vegas, or performing comedy hypnosis in Times Square, Eric's understanding of the human mind astounds audiences worldwide. His show is a side-splitting, mind-boggling event that will leave you believing your dreams are possible.�
Learn more at�www.ericmina.com.�
�This event is sponsored by�Student Programming and Activities for�Campus Entertainment (S.P.A.C.E.).
Share this Event:Email to a Friend
Save this Event:iCalendar vCalendar
Google Calendar
Yahoo! Calendar
Windows Live Calendar


text:
SEO for italian and german site! looking for "pay just if results" - longterm relationship!
This project received 30 bids from talented freelancers with an average bid price of $336 USD.Get free quotes for a project like this
Project Budget$250 - $750 USD
Total Bids30
Project Description
because the last description lead to inadaquate offers we are making a new one.
we are searching a white head seo for our italien and one german site.
we are really good aware of how seo works and what the best longterm strategys are and the last
bids we got were most crap.
we dont accept writing backlinks or article in englisch for out german site or italien site.
the articles and backlinks must be posted in german or italian, depending on which site you are ranking.
also there must be a good longterm strategy and experience in foreign seo. if you dont have this, dont applicate here please.
we are just paying AFTER gettin results - so please keep this in mind!
Skills Required
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
This peppered tuna steak is now available in Coco Beach Island Resort's Carabao Restaurant!
You will surely love the lusciousness of the fresh tuna as it goes along well with the freshly cracked peppercorns and drizzled with calamansi juice and olive oil. The pepper provides a pungent but complimentary counterpoint to the rich flavor of the tuna.
This Peppered Tuna or Tuna Au Poivre comes with a side dish of your choice.
Last Saturday in Coco Beach Island Resort, instead of having the usual Garden Fiesta Party, Chef Noel and his cooks launched the first ever "Coco Food Bazaar" for a change. Four mini bahay kubos were set-up at the Carabao Garden for the following stations, Main Course, Barbeque or Grilling station, Mongolian and Dessert station.
Main Course, Barbeque, Mongolian and Dessert Station
In the Main Course station guest may choose from relyenong bangus, tortang talong with ground beef, kare-kare, fried chicken, pork afritada, fish sarciado, ginataang pusit, ampalaya with egg, ginisang sitaw at kalabasa and steamed rice.
While the Barbeque station have marinated liempo, chicken and jumbo hotdog that is grilled right. Mongolian beef stir-fry, chicken and pork stir-fry are your choices in the Mongolian Station. Have it cooked in front of you and enjoy while it is hot.
And for the Dessert station, Cook Weng of Touch of Asia also prepares buco pandan, buco salad, turon de manila and fresh lumpia.
The party started at 6:30 in the evening with the music of Coco Band. According to the guests the food was great and they find the price very affordable. With almost everyone joined that night we could say it was a big hit.
Australian national Jason Offer and her Filipina fiancé Maricel originally booked for 3 days and 2 nights only at Coco Beach Island Resort. But after 3 days, the couple came back and stayed another 13 more nights as they could not get enough of Coco Beach.
During their stay, the couple did several activities like the free boat tour to one of Puerto Galera's finest beaches, Snorkeling at Bonito Island with one of the boatmen, Tukuran Lagoon tour with friends and visiting Ponderosa Golf Club.
They were fascinated with the colorful marine life and beautiful rock formation they have seen during the free boat tour. Riding on a Carabao cart passing through the river and towering trees before they reached the Tukuran lagoon was new to them and thrilled by the experience. They enjoyed swimming in the lagoon to their hearts content and love the serenity of the place.
We could not help but be proud when they said " You know guys this is the best holiday we ever have, staffs were all friendly, we love your place and everything in here".
To you Jason and Maricel, thank you for all the kind words and for spending your holiday with us. Until next time!
Marinel Sarmiento arrived at the Coco Beach Island Resort for 3 days/2 nights vacation with her sister and other relatives. The group consisted of 16 persons stayed in the classic bungalow close to the beach.
At Coco Beach, the family went to Tamaraw Falls with activity coordinator Belyn. From Muelle port they rode a jeepney for 30 minutes before they reached Puerto Galera's famous Water falls. They enjoyed swimming in the natural pool while basking in the scenic view.
After spending some hours in the falls the group continued to the Mangyan Village and made a short stop at white beach before heading back to Coco Beach.
On Sunday morning some of them went on a fishing trip and were very thrilled when they caught different kind of fishes. The kitchen crew cooked it for them for dinner.
The group shared that they would come back again as they find the place very cozy. Service was so good, staffs were very accommodating and friendly especially the dining department. They added also that you will never get bored while on vacation here as there are so many activities to choose from.
Just before leaving Maria Wilma, Marinel's sister celebrated her 52nd birthday. During breakfast at the Carabao Restaurant the staff greeted her with birthday song and gave her a cake.
Thank you for spending your vacation with us.
Like a famous publisher once said, "Any man can be a father but it takes someone special to be a Dad". On Father's Day let us make him feel special more than anyone else. Coco Beach Island Resort have these activities not only for Father & Son but for the whole family to spend time together.
Early morning a free Fishing Trip for a team of Father & Son was arranged. A great way spending and bonding with Dad while enjoying the beauty of nature. And for adrenaline-loving duo we have the Trekking tour to Mt. Baclayan. This trip gives both the feeling of being so close to nature and a trip you will certainly both remember.
Rodel receives father's day gift
At evening time, a treat to the main man and pillar of the Family with Chef Noel's Special Father's Day dinner which includes Seafood Gumbo, a heavily seasoned soup that combines varieties of seafoods and vegetables, Rib Eye Steak served with mashed potato and pepper or mushroom sauce and Brownie Sundae for dessert, a mouth watering sundae made with brownies, ice cream and chocolate syrup.
On Father's day, all Dads staying at Coco Beach received a magnetic key chain as Father's day gift. Behiya Spa & Salon also gives big, big discount to all Dads who availed their services like a relaxing Aroma Theraphy Massage, Shave & hair Cut, Foot Massage & Pedicure, Signature Massage and Body Scrub.
Happy Fathers Day to all Dads and thank you for sharing this day to us.
Trekking tour to Mt. Baclayan
Follow us
© 1986 - 2017 Coco Beach Island Resort - Puerto Galera, Oriental Mindoro Philippines - By: gofrancis


text:
Nissan GTR Thrill - from just £49
Experience the awesome Nissan GTR R35 - just under 500bhp and the most comprehensive range of driver aids available, with more computing power than all the NASA Apollo rockets added together - surely one of the most amazing mass-produced cars ever!
This special offer is date specific, please choose from the dates below.
For the Full Terms and Conditions of the experience please Click here


text:
It looks like you're new here. If you want to get involved, click one of these buttons!
During a recent conference call, MMORPG.com Associate Editor Suzie Ford had the opportunity to speak with members of the Final Fantasy XIV team including Naoki Yoshida, Director & Producer, Sage Sundi, Global Online Producer and Michael Christopher Koji Fox, Title Translator. The discussion centered around the just-revealed 'road map' for development leading up to FFXIV v2.0 in late 2012. Check out the interview and then let us know what you think in the comments!
I had the privilege of participating in an interview with Naoki Yoshida, the producer and director for Final Fantasy XIV. We spent a bit under an hour discussing all things FFXIV including topics from the past year and topics looking forward into 2012's implementation of v2.0. The discussion was frank and honest about past mistakes and, at the same time, excited about the game's future.
Read more of Suzie Ford's Final Fantasy XIV: Game Overhaul Interview.
Good read! I didn't know the Umbral Era would be a one time, year-long story arc, that's really interesting
It's always good when games fix their problems. Yoshida actually listens and communicates though, which is nice for once.
i really hope this game succeeds. at the least i hope its something ffxi fanbase accepts as a successor. they went from hype to a huge letdown and had to swallow some good old humble pie. its my underdog mmo. that last pic looks pretty sick too. nice lighting. i want to see that come to fruition we good action and pacing.
scribble scribble
ya kudos to them for taking this approach. Hope it works out in the end. Might actually pop in and look around before sub kicks in and see how things are.
Thank you for this interview. It was a nice read.
I'm seriously considering picking it up while there still isnt' a subscription fee and seeing how it's changed from the beta last year. The beta left a horrible taste in my mouth but I've been a big fan of the communication between the dev's and the playerbase, and like the direction of the changes they've made, and their roadmap towards 2.0
But a new engine...I thought they were going to use the one that Squeenix just released some screenshots for. I guess the old one is just that hard to work with, another poor decision made pre-release that's biting them in the ass. Let's hope they've learned what they need to.
Originally posted by mnemic666
I'm seriously considering picking it up while there still isnt' a subscription fee and seeing how it's changed from the beta last year.
Yeah... I did. I mean 30 bucks... If it lasts me longer than 10 hours of gameplay it's already worth more than some of these 60 buck crappy console games. .
But I've never tried it, so it may be a little different for me... however I'm also an "old school" mmo player (I'm less than 25yo, though), so I have a lot of patience.
Anyway... if it's different than the normal unoriginallity, nowadays, I'll probably enjoy it. haha
Great interview!
Yoshi is really doing wonders for SE, not only in terms of his leadership of FFXIV's rebuilding and revamping, but in terms of his being so "present" with the community. Anyone who's followed FFXI knows that engaging their community directly isn't something SE is known for.
All of this coverage is coming, of course, on the heels of the release of the 2.0 roadmap and all that entails (a lot to take in, to be sure; they released a lot of info). However, Yoshi also releases a monthly "Letter From The Producer" wherein he discusses current goings-on, addresses some concerns that are more current within the game's community and also discusses things coming down the line. Through it all, he's very personable and very much "like he's having a conversation".. not merely speaking "at" everyone.
Aside from even that, topics that come up in the forums that garner enough attention (and aren't redundant discussions) will be "crowned", which means it's getting dev attention. This usually results in the topic being brought to Yoshi's attention (or others), and a response is typically provided, via Bayohne, their community rep.
So in terms of the transparency he's discussing, the open-ness of information and the very hands-on and personable approach being taken... Yoshi is really emerging as one helluva blessing for SE to have on their side.
Yes, there are the negative-nancies who are going to bash and flame anything SE says or does... and of course, they're always going to be the loudest. By and large, though, those sticking around in-game, on the forums and such are starting to see an overall change taking place among players... a much more positive one.
I for one am excited to see what the future brings for FFXIV. I love the fact that we're experiencing this sort of "build up" to what 2.0 will be... Good times ahead for sure.
Originally posted by SBFord
WSIMike: You get a +10 from me for using "negative nancies" in a sentence in a manly way. Kudos!
lol thanks!
I'm not sure what a womanly way of using that would be, but hey, I'll take it!
I went from "it's dead" to "I can't wait for this update!" within a few moments after reading the provided pdfs. Yoshi seems to really know his stuff and I'm cautiously optimistic here. After all I think many of us remember the magic of ffxi when it first came out.. a newer version of it would be most welcome. The FFXIV of today doesn't even come close.. but tomarrow? Perhaps. If things go as planned.. I don't doubt I'll be subbing post 2.0 perhaps a bit sooner.
@Hyanmen, yeah... I have a feeling that there's a good number of people who will be sticking around for the next months leading up to 2.0.
If you notice on different forums, especially the official ones, there really aren't many people complaining about it overall. Most of the complaints I see are coming from the same handful of people over there. Seems to me their main beef is "we want to keep playing, but we don't want to pay for it"... and that's it. Whether or not "it's worth paying for" seems to be a hollow argument from many of them.
Now, I know people will say "well most of the people on the official forums are fans, so it's going to be more positive." I would agree, if not for one thing: every single person posting there has to have an account and at least one character in-game to do so. Every single person there verifiably has something to gain or lose by subs being reinstated. So, I tend to take their opinions over that of people on a public forum, such as here or ZAM or elsewhere who can post on the topic and not even have an account to begin with.
A lot of forum-goers, after all, do love to spread negativity to games they don't like, no reason to believe it would be any different in this case.
When someone's played almost non-stop since Sept 21, 2010, has several 50s, other classes over 40 and a smattering of 20+'s, plus pages of achievements listed on the lodestone site, it rings a bit hollow (to me anyway) for one to say "the game isn't enjoyable enough to pay for". Who plays something they don't find "that enjoyable" to that extent, for upwards of 13 months, even if it's free....?
I suppose it's possible for someone to find the game enjoyable enough to play, but not to pay for... but I can't help but think that it mostly has to do with people just being cheap and wanting something for nothing, to be honest.
At the very least, they've more than gotten their money's worth, even if they bought the collector's edition.
I wish them the best of luck and will definitely check out FFXIV come 2.0. Perhaps even PS3 version, as I've always wanted a good console MMORPG for some reason.
I just couldn't get into FFXI and took a "wait and see" approach with FFXIV.
Plenty of gaming to do between now and late 2012/early 2013, but FFXIV will definitely be on my radar.
Looked at all the pdf's from the 2.0 roadmap, impressive stuff.
SE will never let Tanaka near another MMO as long as they have Yoshi. I don't blame them.
From reading some of the comments on the official forums regarding the male Miqo'te I can only hope that Square Enix does not give into those who say they want the males to look like a body builder in a cat suit (i.e. Thundercats). I like the concept art for the male Miqo'te and to me it fits the race perfectly, not to mention it follows what we saw with the male Mithra Lehko Habhoka. The Mithra and Miqo'te are inspired by cats like the Lynx and Serval not lions, the males don't need to look like they are hitting the gym everyday nor do they need to sport huge manes.
I know it's a bit off topic but as someone who has been waiting for the male Miqo'te since it was announced before release that that model existed in game. This is the one thing that kept me from playing FFXIV with any dedication, simply because I knew when they arrived I would be deleting my character (I refuse to pay extra every month for the privilege of having a second character.)
Overall though I am happy with the progress the team is making and while I will not be subscribing, I will return when the game adds the missing sexes.
Because flying a Minmatar ship is like going down a flight of stairs on an office chair while firing an Uzi.
I was so disappointed when I popped my CE disk in at launch, it just wasnt the game I expected like many others. I can see me trying it out again once the new engine is done and the game has a better interface for kb/mouse.
Respect to SE for going this route though.
Originally posted by WSIMike
Yes, there are the negative-nancies who are going to bash and flame anything SE says or does... and of course, they're always going to be the loudest. By and large, though, those sticking around in-game, on the forums and such are starting to see an overall change taking place among players... a much more positive one.
Don't pay attention to these guys. I think the majority of (mature) players are actually excited about the direction the devs are taking and the changes FFXIV is going through. Most of us are anxiously looking forward to playing 2.0. The release was just a mess and there's really nothing we can do about it now, but obviously SE is trying to make it better and succeeding in that.
Finally something positive. I think it was a great article and really tells what I'm seeing as being the truth from Yoshi. This guy is awesome, he seems to really care about the game he's managing and I think that a year from now we're going to see an amazing game unfold.
FFXIV, the Phoenix reborn.
A lot of people are upset about the fact that they're going to start charging again, but I think right now is actually a perfect point in which to begin. Us, as current players, get to witness and experience a game that no one post 2.0 will ever get to and I think that alone is worth paying for. Yoshi has fixed a ton of the problems and is continuing to do so in a pretty timely manner, all things considered.
I guess we'll see in time how things pan out, but so far I have faith in this guy in turning around what was a terrible game at launch. I've actually been enjoying it and that is really surprising if you know me well enough to know my gaming habits.
Hats off to Yoshi & the FFXIV Dev. Team. Good luck on the year coming.
Poor Tanaka, having to make a game on inferior server and graphical technology.
i,ve been kind of popping in now and again to see improvements if any that make this game even remotely playable..well i have to say i just popped in about 3hrs ago and just logged off...and guess what,the interface still sucks big time.when you use most of keys that are assigned to certain things i get no response..attacking is monstrous....most of the time the mobs are stuck between my legs they look like they are giving me a bl-w job..thats the bad part..although i complain about this ..i have just had a read of the roadmap over next year.if they pull it off i will be there because has bad as it still is,i like the game in general well thats my 2 cents..or 2 pence being from the UK.
I'm actually astonished to hear that the PS3 version is still in development. I had figured they weren't even going to bother. But God, they still have that hell-awful UI in there and probably won't be changing it until late 2012? Wow.
I hope that they offer a free month when they launch 2.0. I would like to try the game again with a better UI. The graphics were great but I just couldnt get past the frustration of the controls.


text:
Mozy Home  Mozy 2.4.3
We don't have any change log information yet for version Mozy 2.4.3 of Mozy Home. Sometimes publishers take a little while to make this information available, so please check back in a few days to see if it has been updated.
Can you help?
If you have any change log info you can share with us, we'd love to hear from you! Head over to our Contact page and let us know.


text:
In FEAST OF SHADOWS, the first in the six-part OUR LADY OF SHADOWS story arc. Vampirella is sent by the Vatican to investigate the kidnapping of a little girl by Ethan Shroud and the Chaos cultists, only to become the centerpiece of a ritual invoking Lady Umbra, the sister-bride of Chaos, that leaves her marked as a living sacrifice to the dark goddess who rules the shadows. VAMPIRELLA is back with a new #1 and returns to her horror roots with Bram Stoker Award-winning author Nancy A. Collins (Swamp Thing, Sunglasses After Dark, Jason vs. Leatherface) and Patrick Berkenkotter (Avengers/Invaders, Red Sonja). Superstar illustrator Terry Dodson will provide the main cover, while a veritable who's who of industry talent will provide variant collectible covers. Be sure to order plenty of copies of Vampirella #1, as it hits comic stores everywhere in June!
Nancy A. Collins has spent the last twenty years writing novels, short stories, and comic books for fans of the supernatural, paranormal, and fantastical. Her prose works include Sunglasses After Dark, featuring punk vampire slayer Sonja Blue, the YA series Vamps, a collection of Weird Western tales called Dead Man's Hand, and a collection of Southern Gothic stories entitled Knuckles & Tales. Her comic book work includes Swamp Thing, Jason vs. Leatherface, Machina Jones, and Predator: Hell Come A'Walkin.


text:
In 1873, churches met at this outdoor chapel to hold interdenominational meetings and encourage healing for broken relationships in families and communities split by the Civil War. Families would camp here during their stay. The chapel still has its original wood pews, stage and structure. Stroll around and explore.
Tennessee Vacation eGuide
The 2016 eGuide gives you instant access to Tennessee's irresistible attractions and destinations. Peruse venues online, then put in your order to get a free guide delivered to your doorstep.


text:
Apple Peanut Butter Sliders
These are amazing. The sweet tartness of the apples, the salty, nuttiness of the peanut butter. It just works together so well. Not to mention that this is super healthy. This is vegan, gluten free, and dairy free.
Lee-Ann Photographer
View stunning photos of the Drakensberg Mountains by local photographer.
Limited Time Special Offer
PLEASE LIKE Our Facebook Page
Our people are worried.
They are black and white, middle class and struggling. It is a depth of despair I have not seen before in doing the rounds of town hall meetings with parents, teachers, religious leaders, young people and the aged. They know something is wrong, desperately wrong. It is not the clownish performances of our politicians that disturb them…