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Chemistry of hydrocarbon compounds November recently filed with US Patent Office 11/09Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 11/26/2009 > 6 patent applications in 6 patent subcategories.
20090292149 - Catalyst for liquefied petroleum gas production and method for producing liquefied petroleum gas using the catalyst: P
20090292150 - Integrated processes for making detergent range alkylbenzenes from c5-c6-containing feeds: Integrated processes for making detergent range alkylbenzenes from C5-C6-containing feeds involve feed pretreatment and/or selective hydrogenation to enable acceptable quality alkylbenzene production at attractive capital and operating costs.... Agent: Honeywell/uop Patent Services
20090292151 - Oxygenate conversion to olefins with metathesis: A processing scheme and system for enhanced light olefin production, particularly for increased relative yield of propylene, involves oxygenate conversion to olefins and subsequent oxygenate conversion effluent stream treatment including cross-metathesis of 1-butene with 2-butene, metathesis of 2-butene with ethylene, conversion or removal of at least a portion of the... Agent: Honeywell/uop Patent Services
20090292152 - Series catalyst beds: The invention relates to series reactor beds containing different oligomerization catalysts and having independent temperature control, and processes for the oligomerization of light olefins to heavier olefins using such series reactor beds.... Agent: Exxonmobil Chemical Company
20090292153 - Oxydative dehydrogenation of paraffins: Lower paraffins may be oxidatively dehydrogenated in the presence of an oxidative dehydrogenation catalyst and one or more reducible metal oxides selected from the group consisting of NiO, Ce2O3, Fe2O3, TiO2, Cr2O3, V2O5, WO3, and mixtures thereof optionally with alumina may be dehydrogenated (regenerated) under milder conditions in a safe... Agent: Kenneth H. Johnson Patent Attorney
20090292154 - Modified zeolite catalyst useful for the conversion of paraffins, olefins and aromatics in a mixed feedstock into isoparaffins and a process thereof: The invention relates to a modified zeolite catalyst, useful for the conversion of paraffins, olefins and aromatics in a mixed feedstock such as FCC gasoline that contain high content of olefin, aromatic and n-paraffin into isoparaffins. The invention further relates to the use of such a catalyst, for example but... Agent: Fulbright & Jaworski L.L.P.11/19/2009 > 6 patent applications in 6 patent subcategories.
20090287028 - Process for production of gas hydrate: Disclosed is a process for production of a gas hydrate, wherein the process comprises a gas hydrate production step, a cooling step, a depressurizing step and a re-cooling step. In the cooling step, the temperature (T) required for the cooling of the gas hydrate is adjusted to a temperature equal... Agent: Kubovcik & Kubovcik
20090287029 - Controlling production of transportation fuels from renewable feedstocks: A process for controlling the concurrent production of both diesel range hydrocarbons and aviation range hydrocarbons from renewable feedstocks such as plant oils and animal oils. The process involves determining the required specification of the desired products and the desired relative yields of the product that still meet the required... Agent: Honeywell/uop Patent Services
20090287030 - Oxygenate conversion to olefins with dimerization and metathesis: A processing scheme and system for enhanced light olefin production, particularly for increased relative yield of propylene, involves oxygenate conversion to olefins and subsequent oxygenate conversion effluent stream treatment including dimerization of ethylene to butene and metathesis of butenes and/or hexenes with ethylene. The processing scheme and system may further... Agent: Honeywell/uop Patent Services
20090287031 - Process for simultaneous production of benzene and ethylene by conversion of acetylene: The present invention relates to a process for simultaneous production of benzene and ethylene by conversion of acetylene, comprising the steps: supplying a feed composition comprising about 5 to about 30 vol-% acetylene, about 5 to about 30 vol-% methane, about 5 to about 30 vol-% carbon dioxide and about... Agent: Sabic Americas, Inc.
20090287032 - Method for producing dienes by hydrodimerization: The invention relates to a process for preparing substituted or unsubstituted 1,7-diolefins by hydrodimerizing non-cyclic olefins having at least two conjugated double bonds in the presence of a reducing agent and of a catalyst, wherein the catalyst used is a metal-carbene complex.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090287033 - Reactor for isoparaffin olefin alkylation: An improved reactor for the autorefrigerant alkylation process has a generally cylindrical upright reactor vessel with the inlet for the refrigerant reactant and the sulfuric acid at its lower end and a series of inlets for the olefin reactant at vertically spaced intervals up the length of the reactor. An... Agent: Exxonmobil Research & Engineering Company11/12/2009 > 6 patent applications in 6 patent subcategories.
11/05/2009 > 6 patent applications in 6 patent subcategories.
20090275788 - Hydrogenation processes using functional surface catalyst composition: Hydrogenation processes using a catalyst composition which, preferably comprises a glass substrate, with one or more functional surface active constituents integrated on and/or in the substrate surface. A substantially nonporous substrate has (i) a total surface area between about 0.01 m2/g and 10 m2/g; and (ii) a predetermined isoelectric point... Agent: Honeywell/uop Patent Services
20090275790 - Synthesis of sapo-34 with essentially pure cha framework: A process for producing an ElAPO molecular sieve with essentially pure CHA framework is disclosed. When El is silicon the process allows for a broad range of silicon content, and produces a catalyst with a high selectivity for the conversion of methanol to olefins.... Agent: Honeywell/uop Patent Services
20090275789 - Treatment of small pore molecular sieves and their use in the conversion of oxygenates to olefins: A method is disclosed of treating a porous crystalline molecular sieve having a pore size less than or equal to about 5 Angstroms to decrease its coke selectivity in oxygenate to olefin conversion reactions. The method comprises contacting the molecular sieve with an acid having a kinetic diameter greater than... Agent: Exxonmobil Chemical Company
20090275791 - Ceramic foam catalyst support for gasoline alkylation: This invention relates to an alkylation catalyst, a method for preparing the alkylation catalyst, and a method for alkylating olefins and paraffins. The alkylation catalyst includes a foam catalyst support wherein active catalyst particles have been appended to the surface of the foam support.... Agent: Bracewell & Giuliani LLP
20090275792 - Dehydrogenation process with water control: The activity of a dehydrogenation catalyst is improved by increasing the water concentration maintained in the reactants toward the start of the catalyst's life, but after the catalyst has deactivated to the extent that the temperature required to maintain the conversion per pass of paraffinic hydrocarbon through the reaction zone... Agent: Honeywell/uop Patent ServicesPrevious industry: Organic compounds -- part of the class 532- series
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Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study
DOI: 10.1186/ar3353
© Lee et al; licensee BioMed Central Ltd. 2011
Received: 20 January 2011
Accepted: 8 June 2011
Published: 8 June 2011
Disease remission has become a feasible goal for most rheumatoid arthritis (RA) patients; however, patient-reported symptoms, such as pain, may persist despite remission. We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score (DAS28-CRP4) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria.
Data were analyzed from RA patients in the Brigham Rheumatoid Arthritis Sequential Study with data at baseline and 1 year. DAS28 remission was defined as DAS28-CRP4 <2.6. The ACR/EULAR remission criteria included (a) one or more swollen joints, (b) one or more tender joints, (c) C-reactive protein ≤1 mg/dl, and (d) patient global assessment score ≤1. Pain severity was measured by using the pain score from the Multi-Dimensional Health Assessment Questionnaire (MDHAQ). The associations between baseline clinical predictors and MDHAQ pain at baseline and 1 year were assessed by using multivariable linear regression.
Among the 865 patients with data at baseline and 1 year, 157 (18.2%) met DAS28-CRP4 remission criteria at both time points. Thirty-seven (4.3%) met the ACR/EULAR remission criteria at baseline and 1 year. The prevalence of clinically significant pain (MDHAQ pain ≥4) at baseline ranged from 11.9% among patients meeting DAS28-CRP4 remission criteria to none among patients meeting ACR/EULAR remission criteria. Patient global assessment, MDHAQ function, MDHAQ fatigue, MDHAQ sleep, and arthritis self-efficacy were significantly associated with MDHAQ pain in cross-sectional (P ≤ 0.0005) and longitudinal analyses (P ≤ 0.03). Low swollen-joint counts were associated with high MDHAQ pain in longitudinal analyses (P = 0.02) but not cross-sectional analyses. Other measures of inflammatory disease activity and joint damage were not significantly associated with MDHAQ pain at baseline or at 1 year.
Clinically significant pain continues among a substantial proportion of patients in DAS28 remission but not among those in ACR/EULAR remission. Among patients in DAS28 remission, patient global assessment, disability, fatigue, sleep problems, and self-efficacy are strongly associated with pain severity at baseline and 1 year, whereas inflammatory disease activity and joint damage are not significantly associated with elevated pain severity at either baseline or 1 year.
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes significant pain and disability. Sixty-eight percent of RA patients rate pain as their highest priority for improvement, and 90% of RA patients rate pain as one of their top three priorities [1]. With the earlier initiation of disease-modifying therapies and the development of targeted immunomodulating agents [2], an increasing number of RA patients are able to achieve minimal disease activity, and some are able to achieve complete disease remission [3–5]. However, on a population level, mean pain ratings have remained the same over the past 20-year period [6], and 82% of RA patients who consider their disease to be "somewhat to completely controlled" continue to report moderate to severe pain levels [7].
In a study of Disease Activity Score (DAS28) remission in the Arthritis and Rheumatology Clinic of Kansas and the Rheumatoid Arthritis Evaluation Study databases, mean and median pain scores were 2.43 and 1.50 on a 0-to-10 visual analogue pain scale [8]. Although these values were relatively low, they were higher than the cut-point of 1.25, which separated patients who were satisfied with their health from those who were not. This observation indicated that, even among patients in DAS28 remission, many still have enough pain to negatively affect health satisfaction. It was not clear whether this pain was due to residual inflammatory disease activity or whether this pain was not inflammatory.
Presented with a patient with tender joints and/or pain but no other evidence for inflammatory disease, physicians must decide whether to escalate or add other disease-modifying therapy. If they decide not to increase immunomodulation, they are left with the dilemma of how to address the pain. Currently, very little data exist to guide this treatment decision. The American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) consensus conference for the definition of remission recognized the potential impact of non-inflammatory causes of pain and called for studies to investigate the role of non-RA pain among patients in remission [9].
In this article, we examine the prevalence of clinically significant pain among RA patients in remission according to the DAS28-CRP4 and the ACR/EULAR criteria. Among patients who met the DAS28-CRP4 criterion for remission, we also assess whether pain severity is associated with inflammation or other factors, such as fatigue and sleep problems, which may be indicative of a non-inflammatory chronic widespread pain syndrome.
Materials and methods
Study population
The primary cohort includes the 157 RA patients in the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) who met DAS28-CRP4 remission criteria [10, 11] at both study entry and 1-year follow-up. BRASS is an observational, hospital-based cohort of 1,118 individuals with established RA. Inclusion criteria include age 18 years or older and a diagnosis of RA made by a board-certified rheumatologist. Additional details can be found in a past publication [12]. The Partners Institutional Review Board approved the study, and written informed consent was obtained from all participants.
Remission definitions
The DAS28-CRP4 was calculated from the tender-joint count, swollen-joint count, C-reactive protein (CRP), and patient global assessment [13]. DAS28-CRP4 remission was defined as a score <2.6 [10]. To satisfy the ACR/EULAR remission criteria, participants had to have: 1) ≤1 swollen joint, 2) ≤1 tender joint, 3) CRP ≤1 mg/dl, and 4) patient global assessment score ≤1 (of 10) [14]. The patient global score was taken from the Multi-Dimensional Health Assessment Questionnaire (MDHAQ) item stating, "Considering all the ways that your illness affects you, rate how you are doing."
Study procedures
Participants provided demographic and clinical information, including detailed lists of comorbidities and medication histories. A modified Charlson comorbidity index was constructed by using available data [15]. Hemiplegia and peripheral vascular disease were omitted from the index because these data were not collected. We also did not have data to distinguish between mild liver disease and moderate/severe liver disease, uncomplicated diabetes versus diabetes with end-organ damage, and metastatic versus nonmetastatic tumors. In these cases, point values were assigned based on the less-severe condition (for example, all cases of liver disease were assigned 1 point; all cases of diabetes were assigned 1 point; all tumors were assigned 2 points).
Samples of blood were collected for a standard laboratory panel, including the CRP. Baseline hand radiographs were obtained, and Sharp scores were calculated based on joint-space narrowing and erosions. A physician performed a 28-joint count and assessment of disease activity. Participants also completed the MDHAQ, Mental Health Index-5 (MHI5) and the Arthritis Self Efficacy Scale (ASES). The MDHAQ is a validated instrument that includes assessments of pain, fatigue, and function, scored on 0-to-10 scales (high scores indicate more pain, more fatigue, and poor function) [16]. Specifically, the MDHAQ asks, "How much pain have you had because of your illness in the past week?" and "How much of a problem has fatigue or tiredness been for you in the past week?" The MDHAQ also includes a question regarding sleep problems, scored on a 0-to-3 scale (high scores indicate more sleep disturbances). The MHI5 is a validated five-item assessment of mental health, scored on a 1-to-100 scale (high scores indicate good mental health). The ASES is scored on a 10-to-100 scale (high scores indicate more self-efficacy) [17].
Statistical analyses
Means and standard deviations (SDs) were calculated for normally distributed variables. Median values and interquartile ranges (IQRs) were determined for variables that were not normally distributed. Continuous independent variables were categorized based on tertiles.
To examine the prevalence of pain, clinically significant pain was defined as an MDHAQ pain score ≥4. This threshold was determined based on literature reports requiring pain-severity levels ≥4 of 10 or 40 of 100 for inclusion in clinical trials of pain medications to treat painful conditions, including arthritis [18].
Multivariable associations between baseline clinical variables and baseline MDHAQ pain score were examined by using multivariable linear regression. All multivariable models were adjusted for age and gender. The same methods were used to examine the longitudinal relation between baseline clinical variables and 1-year pain severity, except, in the primary multivariable analyses, baseline MDHAQ pain score was also included as a covariate. Secondary analyses were also conducted, adjusting for age and gender but excluding baseline MDHAQ pain score as a covariate. All statistical analyses were performed by using the SAS 9.2 software package (SAS Institute, Cary, NC, USA).
At baseline, the prevalence of DAS28-CRP4 remission was 24.9%, and the prevalence of ACR/EULAR remission was 8.8% among the 1,118 individuals in the BRASS cohort. The prevalence of remission did not differ significantly between those with 1-year follow-up data (25.3% met DAS28-CRP4 criteria; 8.6% met ACR/EULAR criteria) and those who were lost to follow-up (17.1% met DAS28-CRP4 criteria; 13.0% met ACR/EULAR criteria).
Baseline characteristics of patients in sustained remission
Baseline characteristics of the 157 RA patients in sustained DAS28-CRP4 remission (at baseline and 1 year)
Clinical characteristics
Demographic variables
Age, years, mean (SD)
51.8 (14.0)
Female (%)
135 (86.0)
Caucasian (%)
145 (93.6)
Married/significant other (%)
112 (71.3)
Lives alone (%)
19 (14.1)
Ever smoker (%)
58 (39.2)
Body mass index, kg/m2, mean (SD)
25.0 (4.4)
Modified Charlson index (range, 0-23)
1.0 (0.0, 2.0)
Disease variables
Disease duration, years
6.0 (2.0, 17.0)
Rheumatoid Factor/Anti-CCP positive (%)
113 (72.4)
Tender-joint count
0.0 (0.0, 0.0)
Swollen-joint count
0.0 (0.0, 2.0)
C-reactive protein, mg/L
1.2 (0.5, 2.7)
Patient global assessment (range, 0-10)
1.0 (0.0, 2.0)
DAS28-CRP4, mean (SD)
1.8 (0.4)
Total Sharp score (range, 0-448)
4.0 (0.0, 29.0)
Multi-Dimensional Health Assessment Function (range, 0-10)
0.3 (0.0-1.0)
Multi-Dimensional Health Assessment Pain (range, 0-10)
1.0 (0.5 2.5)
Psychiatric distress/Sleep variables
Mental Health Index-5 (range, 0-100)
80.0 (70.0, 90.0)
Multi-Dimensional Health Assessment Sleep (range, 0-3)
1.0 (0.0, 1.0)
Multi-Dimensional Health Assessment Fatigue (range, 0-10)
2.5 (1.0, 5.0)
Arthritis Self-efficacy (range, 10-100)
82.5 (70.0, 90.0)
Prednisone (%)
31 (19.8)
82 (52.2)
bDMARD (%)
71 (45.2)
Non-MTX, non-bDMARD (%)
22 (14.0)
Combination MTX and bDMARD (%)
36 (22.9)
Combination MTX and non-MTX, non-bDMARD (%)
4 (2.6)
Combination bDMARD and non-MTX, non-bDMARD (%)
7 (4.5)
Nonsteroidal anti-inflammatory drugs (%)
80 (51.0)
Opioids (%)
8 (5.1)
Other pain medications (%)
16 (10.2)
Pain severity at baseline and 1 year
Cross-sectional associations between baseline clinical variables and baseline pain
Cross-sectional associations between baseline clinical variables and baseline MDHAQ pain, adjusted for age and gender, among 157 RA patients in remission at baseline and 1 year
Mean MDHAQ Pain (95% CI)
Disease duration
≤3 years
1.4 (0.8, 2.0)
4-11 years
1.8 (1.2, 2.4)
≥12 years
1.7 (1.0, 2.4)
Rheumatoid factor/cyclic citrullinated peptide status
1.5 (0.9, 2.1)
1.7 (1.2, 2.2)
Tender-joint count
1.6 (1.1, 2.1)
1.5 (0.6, 2.4)
1.8 (0.8, 2.9)
Swollen-joint count
1.6 (1.1, 2.1)
1.2 (0.0, 2.3)
1.7 (1.1, 2.4)
C-reactive protein
<0.7 mg/L
1.5 (0.9, 2.1)
0.7-2.0 mg/L
1.5 (0.9, 2.1)
≥2.1 mg/L
1.9 (1.3, 2.5)
Patient global health assessment
0.6 (0.1, 1.1)
1.4 (0.8, 1.9)
2.9 (2.4, 3.4)
Sharp score
1.8 (1.1, 2.4)
1.9 (1.2, 2.7)
1.2 (0.5, 2.0)
MDHAQ Function Scale
0.6 (0.1, 1.2)
1.4 (0.9, 2.0)
2.9 (2.3, 3.4)
Mental Health Index 5
2.2 (1.6, 2.8)
1.7 (1.1, 2.4)
1.1 (0.6, 1.7)
MDHAQ Fatigue Scale
0.9 (0.3, 1.4)
1.2 (0.7, 1.8)
2.9 (2.3, 3.4)
MDHAQ Sleep Problems Score
1.2 (0.7, 1.7)
2.1 (1.5, 2.7)
2.7 (1.6, 3.8)
Arthritis Self-Efficacy Score
2.1 (1.6, 2.7)
1.9 (1.3, 2.5)
0.9 (0.3, 1.4)
Modified Charlson Index
1.6 (1.2, 2.1)
1.6 (1.0, 2.2)
Longitudinal analyses examining associations between baseline clinical variables and pain at 1 year
Longitudinal associations between baseline clinical variables and 1-year MDHAQ pain, adjusted for age, gender, and baseline MDHAQ pain, among 157 RA patients in remission at baseline and 1 year
Mean MDHAQ Pain (95% CI)
Disease duration
≤3 years
1.6 (1.1, 2.2)
4-11 years
2.0 (1.6, 2.5)
≥12 years
2.4 (1.8, 3.0)
Rheumatoid factor/cyclic citrullinated peptide status
1.9 (1.5, 2.4)
2.1 (1.5, 2.6)
Tender-joint count
2.1 (1.6, 2.5)
1.7 (1.0, 2.5)
1.8 (0.9, 2.6)
Swollen-joint count
2.2 (1.8, 2.6)
1.3 (0.3, 2.3)
1.5 (1.0, 2.1)
C-reactive protein
<0.7 mg/L
1.9 (1.4, 2.5)
0.7-2.0 mg/L
2.0 (1.5, 2.5)
≥2.1 mg/L
2.0 (1.5, 2.5)
Patient global health assessment
1.6 (0.9, 2.2)
1.7 (1.1, 2.2)
2.5 (2.0, 3.0)
Sharp score
2.1 (1.4, 2.7)
2.2 (1.6, 2.9)
1.8 (1.1, 2.5)
MDHAQ Function Scale
1.6 (1.0, 2.2)
1.5 (1.0, 2.0)
2.7 (2.1, 3.2)
Mental Health Index 5
2.2 (1.7, 2.4)
1.7 (1.1, 2.3)
1.9 (1.4, 2.4)
MDHAQ Fatigue Scale
1.2 (0.7, 1.8)
1.8 (1.3, 2.3)
2.8 (2.3, 3.3)
MDHAQ Sleep Problems Score
1.6 (1.1, 2.0)
2.3 (1.8, 2.8)
3.1 (2.2, 4.0)
Arthritis Self-Efficacy Score
2.2 (1.7, 2.7)
2.3 (1.8, 2.8)
1.4 (0.9, 1.9)
Modified Charlson Index
1.9 (1.5, 2.3)
2.2 (1.6, 2.7)
Among patients in sustained DAS28-CRP4 remission for longer than 1 year, the prevalence of clinically significant pain was 11.9% at baseline and 12.5% at 1 year. No markers of inflammatory activity were associated with increased pain severity at baseline or 1 year. Patient global assessment, disability, fatigue, sleep problems, and self-efficacy were strongly associated with pain at both baseline and 1 year.
Although rheumatologists and patients typically think of RA remission as a painless state [19–21], our study shows that remission does not always equal a pain-free state. These findings are significant because pain is considered the most important patient-reported outcome in rheumatology [22], yet it persists in >10% of patients who are classified in remission by DAS28-CRP4 criteria.
The cause of pain in these patients may arise from inflammation, structural joint damage, and/or non-disease-related factors. Our data suggest that inflammation and structural joint damage are not major causes of pain, because CRP, swollen-joint count, tender-joint count, and Sharp scores were not significantly associated with increased pain severity at baseline or 1 year. However, patient global assessment and MDHAQ function scores were strongly associated with increased pain severity at baseline and 1 year. Disease duration was also significantly associated with pain severity at 1 year, although not at baseline.
The patient global assessment and MDHAQ function scores are often interpreted as measures of RA-related joint inflammation and damage, but these measures also reflect a wide range of non-inflammatory factors. Other studies have reported that the explained variance in patient global scores by inflammation is low (6.7%) [23], and MDHAQ function scores are elevated in a wide range of other conditions, including fibromyalgia, a non-inflammatory condition that is not associated with joint damage [24]. RA patients with fibromyalgia have significantly worse physical function compared with RA patients without fibromyalgia, even though sedimentation rates are only marginally higher [25]. Given these observations and the lack of association between Sharp scores, CRP, swollen-joint count, tender-joint count, and high MDHAQ pain scores, we believe that the associations between patient global assessment/MDHAQ function and MDHAQ pain may be attributed to non-RA-related factors, and that the likelihood that inflammation and joint damage are major contributors to pain is low.
The association between disease duration and 1-year MDHAQ pain may reflect joint damage that accrues with increasing disease duration, or it may reflect time-dependent changes in pain processing that lead to a hyperalgesic state. However, disease duration was not significantly associated with baseline MDHAQ pain. This finding weakens the argument that disease duration acts as a proxy for joint damage and raises the possibility that the association between disease duration and 1-year MDHAQ pain may be attributable to chance. Alternatively, these observations are compatible with the hypothesis that increased pain is due to a hyperalgesic state, such as fibromyalgia, that is established and/or enhanced between the baseline and 1-year visits.
The strong association between baseline fatigue, sleep problems, poor self-efficacy, and baseline and 1-year pain severity also supports the existence of an enhanced, non-inflammatory pain state among these patients with pain despite DAS28-CRP4 remission. Fatigue, sleep problems, and poor self-efficacy are part of a noninflammatory symptom cluster associated with "symptom intensification" syndromes [26–28]. These syndromes encompass conditions such as fibromyalgia, which manifest with a broad range of symptoms, including widespread pain, fatigue, sleep problems, and cognitive difficulties. The etiology of these syndromes is unclear but may be associated with deficits in central pain-processing mechanisms, such as central sensitization, that result in hyperalgesia and allodynia [26]. Thus, therapeutic strategies targeted toward correcting central pain mechanisms and improving sleep and self-efficacy may be more effective at decreasing pain than strategies focused on intensifying disease-modifying therapies.
Limitations of this study include the use of the DAS28-CRP4 threshold of 2.6 as the primary criterion for remission. Although the DAS28-CRP4 remission criterion is the most commonly used definition for remission, it is not a perfect measure of inflammatory disease activity. Critics have noted that the DAS28-CRP4 remission threshold of 2.6 permits patients to have multiple tender and swollen joints [29]. In this study, the maximum number of tender joints was three, and the maximum number of swollen joints was 10, confirming these assertions. However, neither tender-joint count nor swollen-joint count was significantly associated with pain severity in cross-sectional analyses. In longitudinal analyses, swollen-joint count was associated with low pain levels, rather than high pain levels. Together with the finding that CRP levels were not significantly associated with pain scores, these observations argue against inflammation as a cause of pain among patients in DAS28-CRP4 remission.
In recognition that the DAS28-CRP4 remission criterion may be too permissive of residual inflammation, we also examined the prevalence of clinically significant pain among patients meeting 2010 ACR/EULAR remission criteria. The prevalence of clinically significant pain in this group was much lower, none at baseline and 5.7% at 1 year. This low prevalence is likely due to the ACR/EULAR criterion limiting the patient global assessment score to ≤1. Because the patient global assessment is heavily influenced by pain [30], this criterion essentially excludes patients with high pain scores. It is not clear whether omitting these patients is appropriate because the ACR/EULAR remission criteria exclude patients with pain due to residual, undetected inflammation or is inappropriate because the ACR/EULAR criteria include patients with non-inflammatory causes of pain. Our data do not allow us to distinguish between these two possibilities because we do not have measurements of joint tenderness and swelling in the feet and ankles. We also do not have radiographic measures to assess subclinical inflammation. Future studies including detailed assessments of inflammation in the lower extremities and radiographic assessments of synovitis are needed to elucidate the relation between inflammation and pain severity among patients in DAS28-CRP4 remission.
An additional limitation of this study is the homogeneity of the study population. The study was conducted at a single academic center, and 93.6% of this population was Caucasian. Other studies have reported higher rates of pain among racial minorities [31], and associations between pain, sleep problems, fatigue, and self-efficacy may differ depending on race. Future studies are needed to evaluate these relationships among different populations.
Pain continues to persist in a substantial subgroup of patients who meet the DAS28-CRP4 threshold for remission, whereas nearly all patients with clinically significant pain are excluded by the ACR/EULAR remission criteria. Among RA patients who meet the DAS28-CRP4 threshold for remission, pain was not associated with inflammatory markers and did not diminish despite continued control of inflammation over a 1-year period. Pain was associated with fatigue, sleep problems, and self-efficacy. These findings stress the importance of assessing alternative causes of pain and modifying therapy to address specific modulators of pain, rather than assuming that pain is an indicator of inflammation that should be treated by increasing immunosuppressive therapies.
American College of Rheumatology
Arthritis Self Efficacy Scale
Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study
C-reactive protein
disease activity score in 28 joints
disease activity score in 28 joints calculated by using CRP and patient global assessment
disease-modifying antirheumatic drug
European League Against Rheumatism
interquartile range
Multi-Dimensional Health Assessment Questionnaire
Mental Health Index-5
rheumatoid arthritis
standard deviation.
YCL is supported by the NIH (AR 057578) and has received a grant from Forest. DHS receives salary support from the NIH (AR 047782, AR 055989) and the Agency for Healthcare Research and Quality. He has also received grants from Amgen and Abbott and is an unpaid member of committees overseeing pain-medication trials sponsored by Pfizer. The Brigham Rheumatoid Arthritis Sequential Study (BRASS) is supported by Biogen Idec and Crescendo Biosciences.
Authors' Affiliations
- Heiberg T, Finset A, Uhlig T, Kvien TK: Seven year changes in health status and priorities for improvement of health in patients with rheumatoid arthritis. Ann Rheum Dis. 2005, 64: 191-195. 10.1136/ard.2004.022699.PubMed CentralView ArticlePubMedGoogle Scholar
- Lee SJ, Chang H, Yazici Y, Greenberg JD, Kremer JM, Kavanaugh A: Utilization trends of tumor necrosis factor inhibitors among patients with rheumatoid arthritis in a United States observational cohort study. J Rheumatol. 2009, 36: 1611-1617. 10.3899/jrheum.080889.View ArticlePubMedGoogle Scholar
- Keystone E, Genovese MC, Klareskog L, Hsia EC, Hall S, Miranda PC, Pazdur J, Bae SC, Palmer W, Xu S, et al: Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: 52-week results of the GO-FORWARD study. Ann Rheum Dis. 2010, 69: 1129-1135. 10.1136/ard.2009.116319.View ArticlePubMedGoogle Scholar
- Keystone E, Fleischmann R, Emery P, Furst DE, van Vollenhoven R, Bathon J, Dougados M, Baldassare A, Ferraccioli G, Chubick A, et al: Safety and efficacy of additional courses of rituximab in patients with active rheumatoid arthritis: an open-label extension analysis. Arthritis Rheum. 2007, 56: 3896-3908. 10.1002/art.23059.View ArticlePubMedGoogle Scholar
- Pincus T, Sokka T, Kavanaugh A: Relative versus absolute goals of therapies for RA: ACR 20 or ACR 50 responses versus target values for "near remission" of DAS or single measures. Clin Exp Rheumatol. 2004, 22: S50-S56.PubMedGoogle Scholar
- Welsing PM, Fransen J, van Riel PL: Is the disease course of rheumatoid arthritis becoming milder? Time trends since 1985 in an inception cohort of early rheumatoid arthritis. Arthritis Rheum. 2005, 52: 2616-2624. 10.1002/art.21259.View ArticlePubMedGoogle Scholar
- Taylor P, Manger B, Alvaro-Gracia J, Johnstone R, Gomez-Reino J, Eberhardt E, Wolfe F, Schwartzman S, Furfaro N, Kavanaugh A: Patient perceptions concerning pain management in the treatment of rheumatoid arthritis. J Int Med Res. 2010, 38: 1213-1224.View ArticlePubMedGoogle Scholar
- Wolfe F, Michaud K: Proposed metrics for the determination of rheumatoid arthritis outcome and treatment success and failure. J Rheumatol. 2009, 36: 27-33.PubMedGoogle Scholar
- van Tuyl LH, Vlad SC, Felson DT, Wells G, Boers M: Defining remission in rheumatoid arthritis: results of an initial American College of Rheumatology/European League Against Rheumatism consensus conference. Arthritis Rheum. 2009, 61: 704-710. 10.1002/art.24392.PubMed CentralView ArticlePubMedGoogle Scholar
- Fransen J, Creemers MC, Van Riel PL: Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria. Rheumatology (Oxford). 2004, 43: 1252-1255. 10.1093/rheumatology/keh297.View ArticleGoogle Scholar
- Fransen J, van Riel PL: DAS remission cut points. Clin Exp Rheumatol. 2006, 24: S29-S32.Google Scholar
- Iannaccone CK, Lee YC, Cui J, Frits ML, Glass RJ, Plenge RM, Solomon DH, Weinblatt ME, Shadick NA: Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study. Rheumatology (Oxford). 2011, 50: 40-46. 10.1093/rheumatology/keq263.View ArticleGoogle Scholar
- Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, Aletaha D, van Riel PL: Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis. 2009, 68: 954-960. 10.1136/ard.2007.084459.PubMed CentralView ArticlePubMedGoogle Scholar
- Felson DT, Smolen JS, Wells G, Zhang B, van Tuyl LH , Funovits J, Aletaha D, Allart CF, Bathon J, Bombardieri S, et al: American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum. 2011, 63: 573-586. 10.1002/art.30129.PubMed CentralView ArticlePubMedGoogle Scholar
- Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40: 373-383. 10.1016/0021-9681(87)90171-8.View ArticlePubMedGoogle Scholar
- Pincus T, Swearingen C, Wolfe F: Toward a multidimensional Health Assessment Questionnaire (MDHAQ): assessment of advanced activities of daily living and psychological status in the patient-friendly health assessment questionnaire format. Arthritis Rheum. 1999, 42: 2220-2230. 10.1002/1529-0131(199910)42:10<2220::AID-ANR26>3.0.CO;2-5.View ArticlePubMedGoogle Scholar
- Lorig K, Chastain RL, Ung E, Shoor S, Holman HR: Development and evaluation of a scale to measure perceived self-efficacy in people with arthritis. Arthritis Rheum. 1989, 32: 37-44. 10.1002/anr.1780320107.View ArticlePubMedGoogle Scholar
- Chappell AS, Ossanna MJ, Liu-Seifert H, Iyengar S, Skljarevski V, Li LC, Bennett RM, Collins H: Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain. 2009, 146: 253-260. 10.1016/j.pain.2009.06.024.View ArticlePubMedGoogle Scholar
- Wolfe F, Boers M, Felson D, Michaud K, Wells GA: Remission in rheumatoid arthritis: physician and patient perspectives. J Rheumatol. 2009, 36: 930-933. 10.3899/jrheum.080947.View ArticlePubMedGoogle Scholar
- Soubrier M, Zerkak D, Gossec L, Ayral X, Roux C, Dougados M: Which variables best predict change in rheumatoid arthritis therapy in daily clinical practice?. J Rheumatol. 2006, 33: 1243-1246.PubMedGoogle Scholar
- Aletaha D, Smolen JS: Remission of rheumatoid arthritis: should we care about definitions?. Clin Exp Rheumatol. 2006, 24: S45-S51.Google Scholar
- Borenstein D, Altman R, Bello A, Chatham W, Clauw DJ, Crofford LJ, Croft J, Hassett A, Kozin F, Pisetsky D, et al: Report of the American College of Rheumatology Pain Management Task Force. Arthritis Care Res (Hoboken). 2010, 62: 590-599.View ArticleGoogle Scholar
- Kievit W, Welsing PM, Adang EM, Eijsbouts AM, Krabbe PF, van Riel PL: Comment on the use of self-reporting instruments to assess patients with rheumatoid arthritis: the longitudinal association between the DAS28 and the VAS general health. Arthritis Rheum. 2006, 55: 745-750. 10.1002/art.22225.View ArticlePubMedGoogle Scholar
- Pincus T, Sokka T: Can Multi-Dimensional Health Assessment Questionnaire (MDHAQ) and Routine Assessment of Patient Index Data (RAPID) scores be informative in patients with all rheumatic diseases?. Best Pract Res Clin Rheumatol. 2007, 21: 733-753. 10.1016/j.berh.2007.02.006.View ArticlePubMedGoogle Scholar
- Wolfe F, Michaud K: Severe rheumatoid arthritis (RA), worse outcomes, comorbid illness, and sociodemographic disadvantage characterize RA patients with fibromyalgia. J Rheumatol. 2004, 31: 695-700.PubMedGoogle Scholar
- Bradley LA, McKendree-Smith NL: Central nervous system mechanisms of pain in fibromyalgia and other musculoskeletal disorders: behavioral and psychologic treatment approaches. Curr Opin Rheumatol. 2002, 14: 45-51. 10.1097/00002281-200201000-00009.View ArticlePubMedGoogle Scholar
- Staud R: Evidence of involvement of central neural mechanisms in generating fibromyalgia pain. Curr Rheumatol Rep. 2002, 4: 299-305. 10.1007/s11926-002-0038-5.View ArticlePubMedGoogle Scholar
- Wolfe F, Rasker JJ: The Symptom Intensity Scale, fibromyalgia, and the meaning of fibromyalgia-like symptoms. J Rheumatol. 2006, 33: 2291-2299.PubMedGoogle Scholar
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- Lati C, Guthrie LC, Ward MM: Comparison of the construct validity and sensitivity to change of the visual analog scale and a modified rating scale as measures of patient global assessment in rheumatoid arthritis. J Rheumatol. 2010, 37: 717-722. 10.3899/jrheum.090764.PubMed CentralView ArticlePubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

subset: commoncrawl


text:
running multiple web apps in a local Eclipse jetty run configuration?
Andrew Mcmurray
Ranch Hand
Posts: 188
Tim Holloway
Posts: 18412
posted 6 years ago
I haven't run Jetty in a long, long time. However, one of the greatest strengths of Eclipse is its ability to work with multiple debuggers - even on multiple computers - at the same time, and I routinely have a copy of Tomcat running under Eclipse with 2, 3, even 4 webapps operating within it.
An IDE is no substitute for an Intelligent Developer.
Andrew Mcmurray
Ranch Hand
Posts: 188


text:
Peanut Brittle
|2 Cup (32 tbs)
|1 Tablespoon
|Light corn syrup
|1 Cup (16 tbs)
|1 Teaspoon
|1⁄2 Cup (8 tbs)
|Baking soda
|2 Teaspoon
|2 Cup (32 tbs)
Combine sugar, syrup, and water in a heavy skillet.
Cook over a low heat until mixture reaches 230° or until it spins a thread about 2 inches long when dropped from a spoon.
Stir in peanuts and continue cooking to 300° or until a few drops tested in cold water separate into threads which are hard and brittle.
Remove from heat and stir in remaining ingredients.
Pour onto a greased platter, spreading as thin as possible.
When cold, break into pieces.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 4290 Calories from Fat 1316
% Daily Value*
Total Fat 157 g240.9%
Saturated Fat 27.7 g138.3%
Trans Fat 0 g
Cholesterol 32.3 mg10.8%
Sodium 3002.2 mg125.1%
Total Carbohydrates 710 g236.5%
Dietary Fiber 24.8 g99.3%
Sugars 503.2 g
Protein 75 g150.9%
Vitamin A 7.5% Vitamin C
Calcium 32.1% Iron 74.6%
*Based on a 2000 Calorie diet


text:
KAISERHOFKnown for being San Diego's best German Restaurant, we specialize in serving the finest German cuisine and offering a wide selection of German craft brews in our Biergarten (Beer Garden). Try our favorites like a Kaiserhof Grilled Sandwich for lunch, or our Bavarian Style Sauerbraten. We offer delectable dinner entrees that range from Wurste, choice-cut Steaks, Chicken, Veal, Seafood and more. Everything is always made in house and always fresh! We're located a few blocks from Sea World in Ocean Beach next to Robb Field and Dusty Rhodes Park. Order online for carryout!
Hours of Business
11:30 AM - 3:00 PM Su 11:30-15:00
4:30 PM - 9:00 PM Su 16:30-21:00
Tuesday - Thursday
4:00 PM - 10:00 PM Tu,We,Th 16:00-22:00
Friday and Saturday
11:30 AM - 3:00 PM Fr,Sa 11:30-15:00
5:00 PM - 10:00 PM Fr,Sa 17:00-22:00


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The Wedding Party
October 20th, 2010
They will beat up your wedding party.
(submitted by Sereli)
They will beat up your wedding party.
(submitted by Sereli)
Cobra Kai! HaYA!!!
Lady GaGa
Beam her up, Scotty!
I……MUST…..BE……NOTICED. Muhhhuuuwhaawhaha
Can you guess which person needs to be the center of attention AT ALL TIMES? With wing flaps like those, the bride is almost invisible. Oh wait, that's her own daughter she's upstaging. Mommy Dearest, revisited.
Someone has to know: is this wedding in America?
Darkside version of the "flying Nun"
Endora attended the wedding of Darren and Sam
I didn't know Maleficant did weddings.
Well you must admit the lady in the big collar definitely knows how to upstage a bride on her wedding day! I love the comments!
Which side of the family does Maleficent belong to?
First thing I thought of when I saw this picture was Maleficent!
I was already laughing at the photo, but your comments left me in tears. I missed the naked sister in law, but the amount of hairspray and catty comments in the dressing room must have been priceless! I couldn't get over how ringbearer #2, next to the Evil Queen, looks like he's about to unfurl his wings and do her bidding.
Where's Waldo?
Whoa. I didn't even SEE the bride at first glance.
Mother of the bride, upstage much?
Far left second row appears to be topless.
WOW!! Your right. That is one low cut neck line. Classy.
Once the bride saw mom's chosen outfit for the wedding she decided to just wad up some toilet paper and stick it on her head, no one was going to be looking at her anyway.
The name's Patsy, Patsy Stone.
They're creepy and they're kooky,
Mysterious and spooky,
They're altogether ooky,
The Addams Family.
Na na na nah (snap fingers twice)
Cut her some slack… She barely made it to the wedding because they were running late on the set of Dynasty
Erma Bombeck says the job of the mother of the groom is to wear beige and keep her mouth shut. I hope this woman at least managed part 2 of that suggestion.
Nah. Dubious.
I had been wondering what Endora there was up to this lifetime …
Apparently the women in this family have not received the etiquette memo that you are not supposed to try to upstage the bride at her wedding. This bride would have needed to borrow Princess Di's dress and added wings to compete with this crowd!
what Di Vinci's "Last Supper" really looked like
i would not have positioned that woman in my picture, especially right in front of me. She took all the attention from the bride!
What was that woman thinking!?!! Trying to take attention away from the bride! Not dressing like everybody else!
Of all the nerve to wear BLUE when she KNEW they were supposed to wear BLACK. Jeez!
Best. Wedding. Photo. EVER! That is just AWESOME! 🙂 The Queen Mum's dress just screams "I'm a sensible woman with a flair for the eccentric. When I go to a wedding, I only go wearing my Wicked Stepmother from Cinderella best."
And they probably could have beaten up my brother and sister-in-law's wedding party of 6…2 bridesmaids, the maid of honor, 2 groomsmen, and the best man. All 20-somethings. We would have been no match! 🙂
That is one crazy M-O-B dress…. If only my mother could have worn that to my wedding
This is the cast photo for the long running soap opera "Hope of our Tomorrows." The woman in the extreme collar has, at some point in the series, been married to every man in this picture (groom included.)
LMAO! What's Susan Lucci doing there on the far left?
OMG – I'm cracking up at both of your posts! YES, I thought Susan Lucci too. I'm still laughing…
I wonder what it's like to have Stevie Nicks as your mother-in-law. Imagine her crooning "Landslide" as a lullaby to the grandbabies in that I-drank-ground-glass voice.
Has anyone figured out the design on the collar? The left side looks like a standard poodle.
And is that a flower in her hair or an off-centered bun? Just asking.
The right side of the collar is a wind up monkey with cymbals.


text:
I will show up on your front porch in a wet t shirt and some mac and cheese
I walked into my room last night at 4 am and there's a random dude in his boxers eating oatmeal on my futon. I looked at him and went to bed
I've woke up with the same hoodie on backwards, twice this week. I think that's a record
This is ridiculous. I'm in fucking college getting high off a potato.
35 Disappointing People Who Failed At Sexting
You sent 2 glasses of water to the table next us and told to the waitress they were on you. I repeat: water
Good luck getting that all cat food off in the shower dumbass
Dude I should have just gone home with the guy with dreads and the cat
Some dude with an OSU jersey just kissed him in the face in front of everyone. I should mention he's wearing a Panda costume. And has already been offered $20 for his suit by Plushies for oral sex.
Like I would feel weird too if you just cancelled our wedding, cut off all your hair and started twerking everywhere
25 Adults Reveal The Most Embarrassing Stories From When They Were Kids
hes that one kid that offered to spoon after staring at me for 5 minutes
i fell into a bathtub last night and broke the fall with my forehead. my forehead is bruised
I left myself a note saying 'buy a hamster but not an orange one like this pen'
omg so drunk
Yeah, but I think it would be a little awkward to explain to Mom that the girl I brought for lunch is not my girlfriend but just a fuck buddy who I met after she hit and totaled my car last month.
Out of curiosity, do you feel happiness for you, or sadness for ME, that you are the only one I drunk text?


text:
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text:
- Description
Quick Overview
Each capsule contains 100 mg of CoQ 10 which works as an antioxidant, giving you a healthy for heart. Co Q-10 is already present in the cells of the human body and is involved in the process that produces cellular energy, however with age it may diminish.
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- Delivers 100 mg of CoQ 10 in a single capsule.
- Promotes a healthy cardiovascular system Ideal supplement for older people.
Coenzyme Q-10 (Natural), Other Ingredients:Gelatin, Soybean Oil, Glycerin, Chlorophyll, Titanium Dioxide (Natural Mineral Whitener) No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Dairy, Yeast Free.
How to use product
As a dietary supplement, take one softgel capsule daily after a meal. Warning: Consult your physician prior to using this product if you are pregnant, nursing or taking medication, or have a medical condition.
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text:
- Light up your biggest rivals with quickness that commands the game. These mens basketball shoes are built for speed and agility, with BOUNCE cushioning and a redesigned traction pattern to enhance your cuts.
- BOUNCE provides energised comfort for all sports, all day
- Textile and synthetic upper
- Grippy rubber outsole
Customer Reviews
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text:
Literature Seminars
ENG 6000. Single / Double Author Seminar (3). Each offering of this course will be devoted to the in-depth study of one, or at most two, author(s). These authors range from Chaucer and/or Shakespeare to Jane Austen, E.M. Forster, Walt Whitman, Emily Dickinson, Adrienne Rich, Joan Didion, as examples, etc. Deep knowledge of an author's (or two author's) oeuvre, not historical coverage, is the chief goal of the course. May be repeated once for up to six hours.
ENG 6100. Genre Seminar (3). Each offering of this course will provide a critical introduction to a single genre of writing. Seminar topics may include everything from the novel, short story, poetry, and drama, to nature or travel writing, the graphic novel, ethnography, and memoir, etc. Deep knowledge of the genre, not historical coverage, is the seminar's chief goal. May be repeated once for up to six credits.
Writing Seminars
ENG 6200. Creative Writing Seminar (3). Each offering of this course will explore the theory and practice of creative writing and an emphasis on revision. Offerings will rotate between Fiction, Poetry, Creative Nonfiction, Writing and the Creative Process, and other possible genres or topics. Deep experience in writing in particular genres is the chief goal of this seminar. May be repeated twice for credit up to nine hours.
ENG 6420. Composition Theories (3). The course provides a basic overview of composition theories: audience analysis, writing process theory, writing to learn theory, discourse theory, invention in the rhetorical tradition. Other topics include evaluation, electronic discourse, and grammar.


text:
Uttermost Bath Vanity Lighting Fixtures
Uttermost Lighting bath vanity lighting assemblies can transform your bathroom's appearance, as well as its atmosphere. Uttermost vanity lights are available in simple light designs or artistic multi-port arrangements. Bathroom vanity lights from Uttermost always ship to you for free and include complimentary light bulbs.
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text:
Home > Eyeglasses > Lacoste > L2770 (424)
New Releases
Size and availability
Free outbound and return shipping
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Free outbound and return shipping
30-day money-back guarantee
Low prices
L2770/424 Eyewear
The term "visual aid" is unsuitable for L2770. This is an accessory that ushers in a new you, emphasizing your clear view on fashion. Would another colour not be a better match for your favourite outfit? Check also the other styles of L2770in our 2015, and 2016 Lacoste range.
The unisex Lacoste model makes no distinction between men and women. Eyewear is in. Full rim is extremely popular, because you feel that you get more eyeglass for your money. It is not just about their resilience, but also about the visibility of material and design, which are of the highest quality. The square shape gives round faces a concise form and makes them appear more striking. It sets a highlight in the appearance, drawing attention to itself. Plastic is a very lightweight and flexible material. This ensures a long life and a high level of comfort. The colour blue is fresh and modern. Having the courage to choose such an exciting colour offers a new approach.
With the help of our digital dispensing optician, your prescription lenses can be configured according to your own requirements. Anti-reflective and cleaning coatings, antistatic and lotus effect are included as standard for plastic lenses.
The next shipment is on its way, so we will have your Lacoste back in stock very soon. We hope the unbelievably low price will be a consolation for the short wait. In our online shop we have consistently low prices. You won't get L2770 at such a low price, not even in the sale.
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The first indications of a compromise deal on raising the U.S. government's debt limit surfaced after President Barack Obama said he could accept a short-term increase in the government's borrowing authority to avert a default. Sen. Rob Portman, R-Ohio, was working on a separate plan to link legislation raising the debt limit to overhauling the U.S. tax code and further cutting government spending, a Senate aide said.
Full Story:Reuters, CNN, The Washington Post (tiered subscription model)


text:
Skip to comments.Obama to give Manhattan back to Native Americans
Posted on 12/30/2010 10:55:38 AM PST by re_tail20
President Obama is voicing support for a U.N. resolution that could accomplish something as radical as relinquishing some U.S. sovereignty and opening a path for the return of ancient tribal lands to American Indians, including even parts of Manhattan.
The issue is causing alarm among legal experts.
In recent remarks at the White House during a "tribal nations conference," Obama endorsed the "United Nations Declaration on the Rights of Indigenous People," which includes a sweeping declaration that "indigenous peoples have a right to lands and resources they traditionally occupied or otherwise used" but that later were acquired by occupying forces.
Read the scoop on the United Nations, in "The Beast on the East River"
"U.N. resolutions like this claiming amorphous rights can be a stalking horse for future attempts to have international courts enforce broad interpretations of those rights at the expense of American sovereignty," Theodore Frank, a fellow with the Center for Legal Policy at the Manhattan Institute, a leading public policy think tank in New York City, told WND.
Academic legal experts indicate that American Indians during the Carter era first drew up plans for reacquisition of lost tribal lands, setting the stage for the U.N. resolution that Obama is embracing. The feasibility study, eyeing 650 million acres of federally owned land in the U.S., was conducted by the Indian Education Institute at Eastern Oregon State, one expert recalled for WND.
"Re-purchase would restore land back to its original owners thus strengthening tribal sovereignty and jurisdiction over its people and land," Julianne Jennings Nottoway, a professor of anthropology at Pima Community College in Tuscon, Ariz., said. "Also, it would allow tribes the opportunity to develop socially, politically and economically as competitors as nation-states within a global context under the act of self-determination."
(Excerpt) Read more at wnd.com ...
I forgot the question mark at the end.
Please read instead:
Obama to give Manhattan back to Native Americans?
Manhattan does not belong to the federal government and certainly not to the UN.
It isn't Obama's or the UN's either!
Peter Minuit bought it fair and square.
The question is how is indigenous defined? Many American Indians think they are indigenous to this continent for example, but archaeology has proven them wrong about that in certain areas.
I won't even begin to try and decide who's indigenous in the parts of Europe and Asia who have been overrun countless times by invasion.
The UN is engaged on an all out assualt on this Country.
Why we allow it to continue is beyond me.
By reason of this UN farce do Mexicans have legal title to the areas occupied by Americans as a result of the Mexican-American War? The current occupant of the White House, due to his hatred of this country and its people, may just authorize transfer of title.
So the Jews get Israel?
You don't expect that to stand in the way of der Fuhrer 0bama, do you?
This is utterly laughable. What a collection of incompetent buffoons we have occupying positions of authority.
"Indigenous" is the new "aryan" ... indigenous supremacy has taken hold of the far left, and with it have come all the inevitable fascist consequences of any "racial supremacy" movement.
Good, Give half the mid east back to the Christians and Jews, Pakistan back to the sikhs....and whoever else mohammet displaced.
Oops that would spell the dissolution of the OIC's "UN"...
AS a person who has indian ancestors, and ancestors in USA for more than 400 yrs, it isn't possible to fix the past. Obama is more interested in destroying America by any means possible. ZERO is a DIVISIVE MAN, and he is using REPERATIONS, PAST ETHNIC PROBLEMS, NATIVE AMERICANS, BLACKS,RACISM, and any other national crisis, as well as FINANCIAL TERRORISM to deceive and accomplish his agenda.
Zero never came to help, and the sooner we get that, along with his lies about being a christian we will all be better off. The Bible says 'you will know them by their fruits (actions)"...and we have already seen his actions.
The first Cro-Magnon family that walks up my driveway and asks (in English) to have my house can have it.
As a Native American, I do not recognize Obama's right of ownership over Manhattan for him to 'give' it to anyone. This is highly insulting to Native Americans and dare I say, a racist move on Obama's part.
Interesting. Haven't thought about it in those terms. You have a point.
"So the Jews get Israel?"
Good point, but we all know the left, in its many incarnations, including the UN, has an infinite capacity for talking out of both sides of its mouth-simultaneously.
So? That hasn't stopped them before from giving away things they don't own.
Oh, GOOD!
They will be able to stop the building of the Ground Zero Mosque!!!!!
Start with the UN building/S
People in the US never pay attention until an issue becomes local or universal. Everything that the Obama administration is doing is aimed at redistribution, including returning rural land to its "rightful owners". It's Agenda 21.
We have been witnessing this movement in WA state for years, but now it has the backing of the Obama administration. Obama even invited representatives of certain tribes (including our local tribe, the Lummis) to the White House, where the Indians were told that Obama intended to return their land to them. One of the locals came back and bragged about it on the web site of the local newspaper. The local interpreted what Obama said as restorative justice, or getting even.
By reason of this UN farce do Mexicans have legal title to the areas occupied by Americans as a result of the Mexican-American War? The current occupant of the White House, due to his hatred of this country and its people, may just authorize transfer of title."""'
How about the land covered by The Louisiana Purchase???
The question is how is indigenous defined?
I have heard this term with increasign frequency and expect that trend to continue. In PC speak, Indigenous is the "new" favored class.
Is this a joke? A satire?
As long as they return the $23 in baubles they received for it originally.
I guess Casinos and tax free tobacco wasn't enough.
I think the new congress should de-fund the UN...if they have such authority...
Found this a while back on the Internet:
In 1776 the Sioux defeated the Cheyenne in war and took the Black Hills from them.
About 100 years later the US did the same to the Sioux.
Why does the first conquest confer legitimate title and the second doesnt?
So who gets the Black Hills, the Cheyenne or the Sioux?
The local interpreted what Obama said as restorative justice, or getting even."
Reparations—Pure & Simple.
Gone far beyond the 40 acres & a mule.
Let-s see— give back land that white Americans now own- to the Indians—who live on major subsistence of the American taxpayers...
Are these Indians going to claim that everything is 'reservation land' & not subject to any property taxes?
Where will the money for the support of the Indians come from in the future???
Take back all of the country & give it back to the Indians—Mexicans—French—Spanish....
How much damage can one administration do to this country?
We will fight back, NObama.
As Whites gradually fade from majority status, look for more and more of this. Except, I guess, it will increasingly be policy instead of nonsense. In their end, they don't really want the land, just the $$. Eventually, every White person will be paying a 50%+ tax for past "crimes" of their ancestors. Already, any Third worlder who wanders across the border has a claim on us. Increasingly that will be codified into law. If nothing changes, inn 100 years, our grandchildren will effectively be slaves—count on it.
Right on! I think I'd rather be under tribal law than Communist rule as I'm now in danger of becoming under the Obamanation.
Native Hawaiians are gonna take this to the hilt - many already do not recognize the Land Court here.
So, McCain said there is nothing to fear of Obama being President and Sarah supports McCain.
People in the US never pay attention until an issue becomes local or universal. Everything that the Obama administration is doing is aimed at redistribution, including returning rural land to its "rightful owners". It's Agenda 21.
We have been witnessing this movement in WA state for years, but now it has the backing of the Obama administration. Obama even invited representatives of certain tribes (including our local tribe, the Lummis) to the White House, where the Indians were told that Obama intended to return their land to them. One of the locals came back and bragged about it on the web site of the local newspaper. The local interpreted what Obama said as restorative justice, or getting even.
I'm indigenous. I was born here, raised here, and have spent my whole life here. My 4 grandparents, though, were Jews from Russia and Poland.
Joke's on them.
This dude gets *everything*.
As does 90% of our reps in Washington, Dems and Pubs.
Soo? What are going to do about it? Complain!!
Really, do a few tribal leaders (are they REAL NA's) think they have a snowballs chance in H of evicting the Manhattanites. This is laughable.
"Obama to give Manhattan back to Native Americans?"
But will they be required to embrace Islam as a condition?
I am, on a level, sympathetic to the suffering of the American Indian. I don't know much about other "indigenous"
people in other parts of the world.
And I support continued efforts to improve their lot in life, short of wholesale "reparations" or giving back parts of Manhattan. That's loony.
I believe most Americans think like me. That's the GOOD news.
Now for the BAD news. IF white Europeans had not come from the East. Then the Japanese, Chinese or Russians surely
would have come from the west. And the treatment of the
American Indian might have been considerably worse by those
people. They might want to ponder the prospect of THAT for awhile.
The fact that the American Indian and other "indigenous" peoples were zoomed past by world civilization, is not the
"fault" of any particular group.
It just IS.
As a result, what these "declarations on the rights of indigenous peoples" are aiming to do is carve out large geographic areas where these "indigenous peoples" are supposed to live under some kind of delusional state of affairs where history is erased and the modern world can be forcibly removed to the extent that it presents a problem of any kind.
In short, they are effectively reduced to the same moral status and legal protection afforded to endangered animals.
Small price to pay for the greatest country in the world though. Especially since you don't have to gamble and you don't have to smoke.
What does Jean Luc Picard have to do with this?
To what tribe would Obama give the island to? It is my understanding that even the Manhattan Indians were not indigenous to the island, and that they found it quite funny that the Dutch were willing to bribe them in order to colonize.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
You agree that when the house is filled with a pleasant aroma, it's just great. air fresheners, of course, provide the desired effect, but it does not last as long as desired.
So I suggest you make your own hands aroma stones.
You will need
- - Finely ground salt - 0.5 stakana-
- - Flour - 0.5 stakana-
- - Warm water - 1/4 stakana-
- - Vegetable oil - 1 tsp lozhka-
- - Essential oils - 5-20 droplets
- - formochki-
- - food coloring.
The large cup is necessary to pour the flour and salt andAll mix thoroughly. Take another bowl. It is necessary to mix ingredients such as oil, warm water and food coloring. Now the liquid mixture to be added an essential oil such as pine or orange and all mix well.
The resulting liquid mixture should be poured into the cupflour and salt and mix everything thoroughly. First, you can knead the mass with a spoon, then his hands. The result should be something like a test.
From the resulting mass of color, tear off a small piece and make it a stone, like a pebble.
Decorate with these stones, you can useall kinds of molds, but note that it should be done before they dry. By the way, does not necessarily make it the stones in the form of shingles, you can make them in the form of hearts or stars.
Allow to dry hack. Aroma stones ready!


text:
Education and Leadership in Change Management in Riyadh, Saudi Arabia Educational Instituations - Phd Proposal
- Status Completed
- Budget £70 - £105 GBP
- Total Bids 7
Project Description
The writer is required to write a 4500 - 5000 word Phd proposal on the following topics: Education and Leadership in Change Management in Riyadh's (Saudi Arabia) Educational Institutions.
A draft proposal has already been prepared (attached) but the following change need to be made to enhance the proposal:
- There needs to be more knowledge to investigate the topic because the aim of the project is very uncertain.
- The proposal is very general phrases about education and globalization, without references to any particular academic framework or situation, and when it comes down to the actual study, it is uncertain what the student wants to do.
- The research questions are very difficult to understand, and the plan of detecting statistical differences in guided interviews does not make sense.
- You need to discuss leadership and educational change in more detail, as they are very broad.
you would need to demonstrate better knowledge and understanding of the academic literature, up to date and from international perspectives. Also the proposal would need to give a better indication of the original contribution of knowledge that the applicant would hope to make in this field.
The proposal attached uses bad English and grammar, so this is something i will be looking for the writer to substantially improve.
• Each question will be a minimum of 4500 words
• Font size : 12pt | 1.5 or double spacing
• Minimum number of references to be used: 30
• you must be available on skype whilst working
You will not be paid if the work is:
1. Below phd standard
2. Plagiarism or improper or inappropriate references used
3. You miss the deadline for the full assignment which is Monday 16th December at 15:00 UK TimeGet free quotes for a project like this
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text:
Logo Design for White Feather Records
This project received 55 bids from talented freelancers with an average bid price of £30 GBP.Get free quotes for a project like this
Project BudgetN/A
Total Bids55
Project Description
To design a logo for a new age music record label called White Feather Records.
White Feather represents the feather that has fallen off the wing of an angel.
The music will be relaxing and meditative as well as chillout and lounge styles.
The music will often have an Indian feel to it.
The logo should have a White Feather or a pair of White Angel Wings and the text White Feather Records and must be subtle,soft and soothing.
We were thinking that the "W" from White feather could be Angel Wings like the attached file and this can standalone as the logo.
To be delivered in High Resolution JPEG & Transparent PNG
Web and print file formats (PSD, EPS, PDF, JPEG, PNG)
Full colour + B&W version
Full copyright to White Feather Records
Fonts to be included
Skills Required
Looking to make some money?
- Set your budget and the timeframe
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text:
- JohnniOmani
- Reviews: 552
David Zandarashvilis Family Hotel: Best Homestay in Georgia
After spending about two weeks in Georgia and another few in Armenia I headed back to Georgia with no set plan. This homestay was recommended by my Israeli friend and so I went with him to chill out for a few days. The family including David (Davit) were some of the nicest folks I have ever met in any country. Their house is well suited for travellers looking to get away and spend some quiet time playing chess and reading books. Three nights later I had to pull myself together and continue on my journey back across Turkey. Davit, his younger brother and mother, father and robogranny (harding working 80 yr old grandmother) will give you 5 star treatment for $10 US dollars a night. Incredible
There are too many qualities to mention but the family , comfortable house, all the food and wine you can drink and Davit will even play traditional Georgian music for you if the mood is right :)
- josephescu
- Reviews: 882
Nana Kokiashvili: Charming place, most friendly & helpful host
continues to be a great, helpful and friendly host, in her charming historical house near the town square. In fact, staying at Nana was a unique experience, I got the feeling of a trip back to a golden age of romantic travel, before mass tourism and industrial civilisation.
No warm water, but this is part ofthe experience. Check her meals, they are excellent.
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Dustin Hoffman did not have to think too long or too hard when he was offered the chance to direct his first film, according to Jane Wright, the managing director of BBC Films, which will make Quartet, the actor's debut from behind the camera lens. A British venture starring Dame Maggie Smith, Albert Finney and Tom Courtenay as ageing opera singers, Hoffman reportedly accepted the challenge with considerable excitement. He had made known his desire to venture into directing, said Ms Wright, adding: "He's got access to incredible amounts of material. This film is the one he really wanted to do". The 72-year-old was, according to BBC Films, "slightly in awe of the cast". It seems beyond doubt that they will be in awe of their director.
Carrying on regardless
The reclusive film-maker Jean-Luc Godard, who is sometimes referred to as "God" and whose rare appearance at a press conference yesterday had been highly anticipated, cancelled his trip to Cannes at the last minute. Godard, 79, had been due to talk about his movie Film Socialisme, which is competing in the "Un Certain Regard" category at the festival. But in a fax to the festival's chief programmer, Thierry Frémaux, Godard reportedly attributed his absence to "problems of the Greek type". Has some kind of tragedy befallen the film-maker? We certainly hope not.
A critical request
The Hollywood Reporter was sent an urgent message by a representative of the esteemed American film critic and screenwriter Roger Ebert, requesting it be broadcast. The acerbic critic has been left unable to speak after a long battle with thyroid cancer. It read: "Reward for Return of Roger Ebert's Computer. A MacBook Pro that he uses to speak with. It was left in a taxi at the Carlton hotel in Cannes on 16 May, inside a brown tote bag. Also contains mini-speakers and a black sweater." Here's hoping the man and his machine are reunited soon.
A moving tale
A sequel to the British-Asian comedy East Is East, which will tell the story of the Muslim father and his English wife struggling to raise their unruly brood of seven children in Salford, is in the works. West Is West will see the family revisited a decade on, with Om Puri and Linda Bassett reprising their roles as George and Ella Khan and Jimi Mistry returning to play one of their sons. The storyline will centre upon Sajid, the youngest of the Khan children, who is taken back to Pakistan, where George has a painful confrontation with his first wife and children – a part of his family that he left behind years earlier.
Bardem steals the spotlight
The actor Javier Bardem poses during a photocall yesterday for the film Biutiful in competition at the 63rd Cannes Film Festival. Bardem, who won an Oscar for his role in No Country for Old Men, takes the lead role in the film by Alejandro Gonzalez Inarritu, the Mexican director behind Babel, 21 Grams and Amores Perros. It is one of 19 entries competing for the Palme d'Or award.
- More about:
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Jill Davies needs to replace a Vauxhall Zafira, bought when her children were at home. She wants a smaller car with good back support. She has £8,000 to spend.
A Car for the Head
To be even more specific, Jill does not want a flashy car, nor a car that is too "nippy" or light. She just wants a vehicle that is comfortable, safe, and a more sedate drive, which she will enjoy and care for. First off, then, we should concentrate on the seating position and clearly a raised one like Jill's old Zafira would be perfect. Now, reliability is also an issue – and the reason I would recommend the high-rise supermini that is the Honda Jazz. Jill would sit in a raised position, good for access. The seats have been judged previously as some of the most comfortable out there. Being a Honda means it has an excellent reliability record and the 1.2 petrol engine will return 50mpg. Jill's budget will buy a 2010 model with 12,000 miles on the clock from a Honda dealer.
A Car for the Heart
Jill loved her Zafira, so in theory she should also adore Vauxhall's smaller-scale Meriva. There was a new model in 2010 and Jill should be able to afford a 1.4 direct from a Vauxhall dealer. It is longer than the old model, so there is no shortage of legroom or luggage space, for that matter. The really interesting thing about the new Meriva is that the rear doors are hinged differently, so that the front and rear doors meet in the middle. It is better for access, but Jill should be happy enough with the driving position, which is suitably high. There are lots of specification levels starting with the Expression and S, and Jill should go for the Excusiv, which at least has air conditioning. For £8,000, Jill will be able to afford a 2010 1.4 with just over 12,000 miles.
Looking to buy?
Email James Ruppert at firstname.lastname@example.com, giving your age, address and phone number, details of the type of vehicle in which you are interested, and your budget.Reuse content


text:
Baby Name Poll Results
Fiona vs. and vs. Mavi
Hey, we are expecting our second daughter due in December. Our elder daughter is Fiona (1). For our baby-to-be we would like the name Mavi. What do you think? Would Fiona and Mavi fit? Thank you!
The Top Baby Name is...
|33% (1 votes)
|0% (0 votes)
|67% (2 votes)
I don't think Fiona and Mavi go together at all. Fiona is a classic Irish name and Mavi is a made up celebrity baby name. What about Maeve or Maeva with the nn Mavi? Maeve is Irish, ages well and goes great with Fiona and you can still call her Mavi if you wanted
posted by guest :: 2013-11-15 12:07:38 | report
I second the suggestion of Maeve
posted by guest :: 2013-11-15 12:08:07 | report
Maeve or Mavis look better imo
posted by guest :: 2013-11-15 12:10:24 | report
I agree with the first poster.
posted by guest: Nicola :: 2013-11-15 12:30:26 | report
Post a Comment:Please keep your comments positive and helpful.
Even if you don't like the names. Thanks!
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Prince Sado
Feb. 13, 1735
Jul. 12, 1762
Korean Royalty. Born the second son of King Yongjo of the Choson Dynasty and his concubine Lady Sönhui some seven years after his elder brother, Crown Prince Hyojong's died in 1728. At three months, the new prince was moved into the Chosung-jon Mansion, the traditional palace of the Crown Prince. An apparent prodigy, the prince was reported as walking at four months, and by two, he could write about sixty Chinese characters. Apparently, the king wished to been seen as the most Confucian of rulers, and his son's personality did not lend itself to such a discipline. An estrangement between father and son grew. On April 27, 1744 Sado married eight year old Lady Hyegyong. Over the winter of 1745, Sado fell seriously ill with an unnamed malady. Sado celebrated his coming-of-age on March 10, 1749. Five days later, he began married life with his princess, and a son was born the following year. A second son, Prince Chöngjo, was born in 1752, the same year Sado fell ill during a measles epidemic. The illness apparently exacerbated various abnormal behaviors the prince had suffered since his lengthy illness of seven years before. He began suffering from delusions and nightmares; in the summer of 1756 the prince began acting violently toward his servants. He became ill with smallpox that winter, and though he recovered, the Queen and Queen Dowager died the spring of 1757. These events apparently worsened the prince's derangement. He beat his eunuch's, raped court ladies he could not seduce, and finally began killing household servants as the mood took him. In January 1761, Sado mortally injured his own concubine. He stalked his own sister, Hwawan. He began wearing disguises and wandering about Seoul incognito. He then began killing people at random; fortune tellers; royal physicians, translators, and court workmen all died at his hands. The court lived in terror of the prince. In June 1762, King Yongjo received a letter from one of his ministers, informing him of the gross misconduct of the Crown Prince. King Yongjo finally decided that Prince Sado was too dangerous to be allowed to live. The King ordered court eunuchs to fetch a large rice chest, and the prince was ordered into it. The lid was then nailed shut and Sado was left to die. After eight days, the prince was dead. Sado's eunuchs, court guards, workmen and shamans were put to death as well. His wife was demoted to commoner status and returned to her family home. His unfortunate sister, Princess Hwawan was demoted, sent into exile and poisoned. In 1776, Prince Sado's second son ascended the Phoenix Throne as King Chöngjo, as soon as he took the throne, he purged all those he held responsible for his father's death. He honored his father as if he had in fact been a reigning monarch. Sado's grave site is now a UNESCO World Heritage Site.
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Jackie Howard
Added: Feb. 13, 2014
Wish this rose was the Rose of Sharon. I am so sorry the cruelity your own flesh and blood showed you! Love to you and and your very intelligent Queen , who , spent so many years in the palace helping guide the country in the right direction.
Ivory Penny Jean Upthegrove
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- {{matchup.date.fullday}}{{matchup.date.month + ' ' + matchup.date.day}}
Portland vs New Mexico Recap - New Mexico Wins 69-54
Alex Kirk scored 14 points leading New Mexico to a 69-54 victory over Portland at The Pit on Sunday.
New Mexico earned a straight-up victory but suffered an ATS defeat in failing to cover the 19-point spread.
New Mexico got 12 points from Jamal Fenton and another 10 points from Hugh Greenwood. Tony Snell contributed 4 assists, while Alex Kirk cleaned the glass with 11 rebounds.
Portland got 11 points from Kevin Bailey in a losing cause and another 11 points from Korey Thieleke. Kevin Bailey contributed 3 assists for them, while Ryan Nicholas had 9 rebounds.
New Mexico led at halftime, 30-27.
New Mexico won the battle of the boards, outrebounding their counterparts 44-35.


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My child has
Cook Children's sponsors a select number of events that are strongly aligned with its promise to improve the health of every child in the region through the prevention and treatment of illness, disease and injury. Our strategic plan is the driving force of sponsorship decisions, and the opportunities that are ultimately funded must make a positive impact on the local communities that we serve, specifically support our promise and improve pediatric health.
Sponsorship is defined as direct financial or in-kind support for special events, and may include – though not limited to – nonprofit agency fundraisers (breakfasts, luncheons, dinners), speakers series/lectures, fun run/walks, health fairs, golf tournaments or other community activities). To facilitate the process, we ask that one sponsorship request be submitted per organization per fiscal year. We will not accept multiple sponsorships from the same organization; therefore we ask that you look at your sponsorship needs as a comprehensive request for sponsorship.
Please review Cook Children's sponsorship guidelines and if your event falls within these basic parameters, complete the sponsorship request form for formal consideration of Cook Children's sponsorship.
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SmallAppliance.com is your one stop shop for all your kitchen appliances and more. They carry bakeware, blenders, bowls, bread machines, can openers, chocolate fountains, deep fryers, food processors and more. SmallAppliance.com also offers a repair service for your appliances. With their wide variety of of parts, accessories, appliances, shavers, you cannot go wrong.
We do not offer cash back at this time. Hopefully we will be able to in the future! :)


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: GIGABYTE G1 Gaming GA-Z170N-Gaming 5 (rev. 1.0) LGA 1151 Intel Z170 HDMI SATA 6Gb/s USB 3.1 USB 3.0 Mini ITX Intel Motherboard
Pros: giving a neutral 3-star rating because I hope I won't be getting so far as powering it up.
Cons: As other reviews have stated, four of the 6 SATA connects are right-angle and so cannot be used with the normal straight-in SATA cables. I started the assembly in a Silverstone FTZ01 before realizing my mistake (and Gigabyte's stupidity).
Other Thoughts: It might be possible to use "left-angle" SATA cables. But that "solution" would only allow use of 2 of the 4 rear-facing conectors.
I've ordered some, but they haven't come yet, and so cannot say for sure that it fits. My measurement says it will but it is VERY tight...some things may be "compressed". But I've decided to return it if I can since I'm building a nice system. If I cannot return it, I'll dispose of it somehow. Save yourself the trouble, don't buy this....there are better choices (or at least they don't have this problem).
This review is from: ENERMAX Aurora Black 104 Normal Keys USB Mini Keyboard
Pros: Heavy, low-profile feels like "quality".
They promptly supplied an RMA.
Cons: A key failed at 11 months under light home use so
that it's hard to believe the spec "10 million plus keystroke lifetime". After no action and no communication for a month, I learned they were out-of-stock of the KB002U.
Other Thoughts: The KB002U model is no longer on the Enermax website.
The newegg link is stale.
It appears to be replaced by the KB007U which is what Enermax gave as a replacement under the 1 year warranty.
This review is from: ASUS M2A-VM AM2 AMD 690G Micro ATX AMD Motherboard
Pros: It was very nice for a change to have all the required drivers on the installation disk (especially since this was for Vista Ultimate 32). I also like the fanless NB/SB cooling. When it comes time to inherit my son's
PCI-Express x16 graphics card, there's a place to use it. The ability to populate to 3GB economically was also a plus (Some other 690G boards have only 2 DIMMs.)
Cons: The only con is that the asus support website has been having problems lately--not that I needed to fix anything, but I was just curious if there were any problems (none posted) or updates (none posted).
Other Thoughts: 1. I have no problem playing DVDs through the on-board graphics under Vista Ultimate (I was pleased & surprised that it included a DVD codec); if anyone is having problem with that maybe software is the problem. When Blu-Ray drives
become economical this board may well become an HTPC.
2. Regarding memory timing:
I think it is true that you cannot adjust the cycle-count latencies, but you can adjust the frequencies (without it automatically changing the cycle-counts). At first I had DDR2-800 installed & it automatically set the freq to 867! I ended up with DDR2-677 ECC-unreg & I manually set it to DDR2-800 with no problems in MEMTEST86+ or installation/running.


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