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Why and how did you get into poly?
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Join Date: Nov 2010
Location: The Big Apple
Posts: 10,083
Originally Posted by
As long as we are using monogamy to mean: romantic exclusivity (sexual and emotional), I disagree that monogamy does not preclude autonomy.
I did not say that monogamy does not preclude autonomy. I said it does not
preclude autonomy. Losing or giving up one's autonomy is not an across-the-board requirement of all monogamous relationships. How could it be? There are many flavors of monogamy, because individuals are involved - why do poly people think they are the only ones with variety?
Any relationship configuration is going to depend on the people involved. Yes, many people do make demands on their partner to be exclusive; and yet for others, both partners willingly and happily embrace, invite, and accept exclusivity. Still, exclusivity does not negate a person's autonomy. An individual can be autonomous, be their own person, have the freedom to express their individuality, live life in their own way AND YET happily choose to be monogamous. There is no rule that these things have to be abandoned to be monogamous.
Personally, I've had many monogamous relationships where I did not give up my autonomy, and I have observed the same in many other monogamous couples where they were loving, mutually supportive, and free to express who they were. It's a shame that so many poly people don't seem to have observed much of that, or do they just refuse to see it? ( <-- more likely) Monogamy and polyamory are just relationship structures, neither of which is the be-all-and-end-all key to happiness. Happiness and autonomy can be had in nearly any relationship configuration - it's the person who makes the difference, not how many people they love or have sex with that determines how much personal power they retain, own, express, etc.
Sure, a monogamous relationship can be fucked up and the people in it utterly co-dependent, but that can happen in polyamory, too. Polyamory does not
encourage autonomy just as monogamy does not
prevent it. Your relationships are what
make of them, not what the structure and dogma of a particular culture make of them.
The world opens up... when you do.
"Oh, oh, can't you see? Love is the drug for me."
~Bryan Ferry
"Love and the self are one . . ."
~Leo Buscaglia
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|Table of Contents
|Vol. 35, No. 5-6, 2013
Issue release date: May 2013
|Section title: Original Research Article
Aromatase Variants Modify Risk for Alzheimer's Disease in a Multiethnic Female CohortJanicki S.C.a-c · Park N.a, b · Cheng R.a, b · Schupf N.a,b,d,g · Clark L.N.a,e,f · Lee J.H.a,b,f,g
aTaub Institute for Research on Alzheimer's Disease and the Aging Brain, bGertrude H. Sergievsky Center, Departments of cNeurology, dPsychiatry and ePathology and Cell Biology and fCenter for Human Genetics, College of Physicians and Surgeons, Columbia University, and gDepartments of Epidemiology and Psychiatry, Columbia University Medical Center, New York, N.Y., USA Corresponding Author
Sarah C. Janicki, MD, MPH
Gertrude H. Sergievsky Center, Columbia University Medical Center
P&S Box 16, 622 West 168th Street
New York, NY 10032 (USA)
E-Mail email@example.com
Background/Aims: Few studies of gene variants that affect estrogen activity investigate their association with risk for Alzheimer's disease (AD) in women of different ethnicities. We investigated the influence of CYP19 polymorphisms on risk for AD in a multiethnic cohort of women, with individual ethnicity assessed by genetic population ancestry informative markers (AIMs) as well as by self-identified ethnicity. Methods: Among 1,686 women participating in the Washington Heights Inwood Columbia Aging Project, association with risk for AD was assessed for 41 single nucleotide polymorphisms (SNPs) on the CYP19 gene using multivariable logistic regression, adjusting for age, presence of an APOE ε4 allele, years of education, and body mass index. Results: Risk for AD was associated with 6 SNPs in women of predominantly Caucasian AIMs-defined ancestry. Of these, 2 were also associated with decreased risk of AD in women of admixed/Hispanic AIMs ancestry. Two separate SNPs were found to be protective in women of predominantly African AIMs-based ancestry. Conclusions:CYP19 polymorphisms affect risk for AD in women, and risk alleles vary by AIMs-defined ancestry. These effects are possibly due to linkage disequilibrium patterns or differences in the prevalence of comorbid risk factors mediating the SNP effect on risk for AD by group.
© 2013 S. Karger AG, Basel
Alzheimer's disease Alzheimer's disease and Hispanics Estrogen Genetic polymorphisms in degenerative dementias Genetic risk factors CYP19 gene
Estrogens are important in maintaining brain function in regions typically affected by Alzheimer's disease (AD) and variations in estrogen exposure over the lifetime may affect cognitive decline associated with AD [1,2]. However, evaluating the role of hormones and enzymes in aging and cognition is difficult since many hormone levels decline with age. It is likely that polymorphisms in genes encoding the estrogen synthesis pathway contribute to variations in lifetime hormone exposure, including age-related changes in hormone levels. Estrogens including estradiol and estrone are formed locally in the brain from the conversion of androgens by aromatase [3], a cytochrome p450 enzyme encoded by the CYP19 gene located on chromosome 15q21.2. Several studies [4,5,6], but not all [7,8], have found an association between multiple single nucleotide polymorphisms (SNPs) in CYP19 and AD. However, most studies have been conducted in Caucasian ethnic groups, and few polymorphisms have been assessed in a multiethnic cohort in which the members have all been evaluated in a consistent manner. Examination of SNPs in multiethnic groups which are evaluated without taking ancestry into account may have several limitations, including a loss of significant association due to different allele frequencies, different linkage disequilibrium (LD) patterns between ethnicities, or differences in the distribution of comorbid conditions and risk factors for AD by ethnic group. In this study, we examined the relationship between CYP19 SNPs and the risk of AD in a multiethnic cohort of elderly women from northern Manhattan, with individual ancestry assessed by population ancestry markers as well as by self-identified ethnicity [9]. The aims of this study were to confirm previous findings of CYP19 polymorphisms which were found to be significantly associated with risk for AD, to identify additional SNPs which confer risk for AD using a denser set of SNPs than in previous studies, and to examine whether CYP19 variants would affect risk for AD differently in groups of women with different population ancestry. We hypothesized that genetic variants would demonstrate different patterns of association between groups with different population ancestries due to distinctive allele frequencies or LD patterns between ethnic groups, as well as varying environmental factors.
The study included 1,686 women participating in the Washington Heights Inwood Columbia Aging Project (WHICAP), a prospective study of aging and dementia among Medicare recipients aged 65 years and older, residing in northern Manhattan. The population from which the participants were drawn was comprised of individuals from several different countries of origin representing three broadly self-identified ethnicities (Caribbean Hispanic, African-American, and non-Hispanic White of European ancestry). The sampling strategies and recruitment outcomes of these three cohorts have been described in detail elsewhere [9].
Each subject underwent an in-person interview of health and functional ability followed by a standardized medical assessment and neuropsychological battery [10]. Assessments were conducted at 18- to 24-month intervals over a mean of 6.1 years of follow-up. AD diagnosis was based on NINCDS-ADRDA criteria. We used a conservative definition of AD in our analyses, excluding definitions of mild cognitive impairment or isolated low neuropsychological scores in order to obtain the most robust phenotype.
This study was reviewed and approved by the Columbia University Institutional Review Board, and written informed consent was previously obtained from all subjects.
Genomic DNA was extracted from total peripheral blood leukocytes using standard methods. We used a multistep selection process to identify candidate SNPs for genotyping. We first selected SNPs within CYP19 that were previously reported to be associated with an increased incidence or earlier age at onset of AD in any population. We then referenced the International HapMap Project (www.hapmap.org) to select tagging SNPs in both Caucasian and African populations. To provide sufficient coverage of the gene, we selected SNPs to maintain a pairwise r2 threshold of 0.8 in SNPs with a minimum minor allele frequency of 0.2. We obtained an average intermarker distance of approximately 3.0 kb between SNPs, which provided good coverage of the gene as viewed on LD maps (online suppl. fig. 1-3; for all online suppl. material, see www.karger.com/doi/10.1159/000343074).
Forty-one CYP19 SNPs as well as 100 ancestry informative markers (AIMs) were genotyped in a total of 1,686 samples using Illumina GoldenGate custom panels and the Illumina IScan platform. Genotyping was performed according to standard protocols (www.Illumina.com). Duplicate genotyping was performed on 10% of samples to verify accuracy, and the concordance rate was greater than 98%.
To evaluate population stratification, we used a set of 100 unlinked AIMs to classify population ancestry. We selected the 100 unlinked SNPs from a panel of 650Y Illumina SNPs using a subset of subjects that had previously also had GWAS data collected. The AIMs were selected because they have allele frequencies that are significantly different among the three ethnoracial groups: non-Hispanic Whites, non-Hispanic African, and individuals of Mexican/Central American ancestry. To assess population stratification, we performed population structure analysis as implemented in the Structure program [11,12]. To anchor ancestry, we included data from Caucasians (CEPH), Yorubans (YRI) and Mexican/Central Americans from the HapMap project (fig. 1). Our self-identified White population closely aligned with the Caucasian (CEPH) samples in the HapMap dataset and our self-identified Black population clustered around the Yoruban (YRI) samples. As expected, Caribbean Hispanics clearly showed admixture of Caucasian (CEPH) and Yoruban (YRI) genetic population ancestry, and the range of admixture varied widely. We then classified participants into groups who were of predominant Caucasian ancestry as defined by the AIMs index (defined as ≥0.6 AIMs markers consistent with CEPH profile, n = 632) versus those who were of predominant African ancestry (defined as ≥0.6 AIMs markers consistent with YRI profile, n = 581). In doing so, individuals previously self-identified as Hispanic were reclassified as being of predominant Caucasian or African AIMs-defined ancestry (if their AIMs index scores were ≥0.6 CEPH or YRI, respectively), or admixed/Hispanic if they did not have one predominant genetic ancestry (n = 473). Comparison of populations as defined by AIMs-defined ancestry versus self-identified ethnicity is illustrated in online supplementary table 2.
Potential confounders included age at time of study enrollment, presence of an APOE ɛ4 allele, years of education, and body mass index (BMI). Supplementary analyses (online suppl. fig. 4-6) were also performed to evaluate the potential effects of vascular risk factor covariates on significant SNPs, and included history of diabetes mellitus and current smoking. Participants were classified according to the presence or absence of at least one APOE ε4 allele. Height and weight were measured at the initial evaluation to compute BMI. History of diabetes mellitus was defined as self-reported current or past history of treated or untreated diabetes.
Prior to association analysis, we assessed whether each SNP was in Hardy Weinberg equilibrium. This analysis was performed separately within each self-identified ethnicity as well as within each AIMs-defined population of unaffected individuals using the χ2 goodness-of-fit test in Haploview [13]. SNPs were then evaluated in genotypic association analyses to further characterize their relationship to AD, stratifying first by AIMs-defined ancestry and then by self-reported ethnicity. We hypothesized that differences in associations between these two sets of analyses might reflect culturally associated environmental risk factors for AD. Conversely, similarities in significant SNPs between the two analyses would demonstrate a more direct genetic effect of CYP19 polymorphisms on risk for AD. We used multivariable logistic regression to estimate the likelihood of AD by SNP genotype, adjusting for age, presence of at least one APOE ε4 allele, and BMI. To provide the most robust model for observing an effect of the minor allele, SNPs were analyzed using a dominant model, in which participants homozygous for the common allele were used as the reference group and the risk group included participants who were heterozygous or homozygous for the minor allele.
Table 1 presents the demographic characteristics of our cohort. The mean age of the participants at baseline was 77.0 ± 6.7 years (range 65-95 years). Mean length of follow-up was 6.1 ± 4.3 years. The majority of women were self-identified as Hispanic (n = 672, 39.9%) and Black (n = 574, 34.0%), while 423 women were self-identified as White (25.1%). Among all the participants, 511 were classified as possible or probable AD (29.5%) and 1,175 as nondemented. The frequency of AD was greater in self-identified Blacks and Hispanics than in Whites (Blacks: 32.2%, Hispanics: 38.2%, Whites: 15.3%). Mean years of education differed significantly between those with and without AD (7.1 vs. 10.4 years). BMI, history of diabetes mellitus, and current smoking status did not differ significantly between individuals with or without AD. However, there were statistically significant differences between self-identified groups as well as between AIMs-defined populations in the prevalence of vascular risk factors, including diabetes mellitus and current smoking (table 2). The proportion of women with at least one copy of the APOE ε4 allele was highest in Blacks, followed by Hispanics and then Whites (table 2).
For ease of discussion, we will use the numbered order of SNPs to refer to each SNP (table 3). Among women of predominantly Caucasian AIMs-defined ancestry, 2 SNPs (SNPs 10 and 15 - rs4775935 and rs727479, respectively), located at the 5′ end of the CYP19 gene, were found to be associated with decreased risk for AD, adjusting for age, BMI, and presence of an APOE ɛ4 allele. Four SNPs (27, 28, 37 and 39 - rs17647719, rs1902586, rs10163138, and rs7168331), clustered at the 3′ end of the gene, were found to be associated with increased risk for AD. Odds ratios (ORs) varied between 0.6 and 0.7 among protective SNPs (table 3), and ranged from 1.7 to 2.6 among SNPs associated with increased risk for AD. Among women of admixed/Hispanic AIMs-defined ancestry, SNPs 10 and 15 were also found to be protective (OR 0.6 and 0.7, respectively). Two different SNPs (SNPs 38 and 41- rs6493495 and rs11070843) were associated with decreased risk for AD in women of predominantly African AIMs-defined ancestry, both with ORs of 0.7 (table 3). To minimize the risk of false-positive findings from multiple testing, we computed empirical p values by generating the null distribution on the basis of 1,000 replicate data sets. As shown in table 3, calculation of empirical p values slightly attenuated the degree of significance for some genotypes (including SNP 15 among women of admixed/Hispanic AIMs-defined ancestry and SNP 38 among women of predominantly African AIMs-defined ancestry); however, most remained significant.
We then repeated the analyses within strata defined by self-identified ethnicity to take into account the potential role of cultural/environmental risk factors within ethnoracial groups (online suppl. table 1). Among self-identified Whites, SNPs 10 and 15 remained significant while ORs for the remaining 4 SNPs that were significant among women of predominantly Caucasian AIMs-defined ancestry became attenuated and were no longer significant. However, 4 additional SNPs flanking the region - specifically, SNPs 5, 16, 18 and 19 - were found to be significant. Among self-identified Hispanics, 2 significant SNPs (10 and 16) were found in close proximity to those in the AIMs-defined ancestry groups for Hispanics and Whites. Among self-identified Blacks, 2 protective SNPs (SNPs 38 and 31) were no longer found to be significantly associated with risk for AD.
Genotypic analyses demonstrated that SNPs associated with risk for AD clustered in several distinct regions of high LD (online suppl. fig. 1-3). Strong pairwise LD between SNP loci in these blocks supported the possibility of multilocus association at adjacent variants. We performed 'sliding window' haplotype analysis within these regions as implemented in the Haploview program using the D′ value [13], with each haplotype including 2-4 consecutive SNPs. While numerous haplotypes constructed from these CYP19 SNPs were found to be significantly associated with increased or decreased risk for dementia, the most robust associations in women of predominantly Caucasian AIMs-based ancestry were haplotype AA at SNPs 10-11 (OR 0.4, p = 0.001) and haplotype AAC at SNPs 37-38-39 (OR 3.17, p = 0.04; data not shown). Among women of admixed/Hispanic AIMs-defined ancestry, the most significant haplotype was GCAG at SNPs 14-15-16-17, which was protective (OR 0.6, p = 0.008). Among women of predominantly African AIMs-defined ancestry, only one protective haplotype, GG at SNPs 40-41 was found to be significant (OR 0.72, p = 0.04; data not shown).
Among 1,686 community-dwelling elderly women in a multiethnic cohort, risk for developing AD was associated with 6 SNPs in women of predominantly Caucasian AIMs-defined ancestry (rs4775935, rs727479, rs17647719, rs1902586, rs10163138 and rs7168331). Of these, 2 SNPs (rs4775935 and rs727479) were associated with decreased risk of AD in women of admixed/Hispanic AIMs ancestry. Additionally, 2 different SNPs (rs6493495 and rs11070843) were found to be protective in women of predominantly African AIMs-based ancestry. Use of empirical p values slightly attenuated the degree of significance for rs727479 among women of admixed/Hispanic AIMs-defined ancestry and rs6493495 among women of predominantly African AIMs-defined ancestry; however the directionality and magnitude of effect remained the same.
Numerous papers have established that estrogen may have beneficial effects on multiple pathways that affect risk for AD. Estrogens promote the growth and survival of cholinergic neurons [14,15], increase cholinergic activity [16], have antioxidant properties [17], and promote the nonamyloidogenic metabolism of the amyloid precursor protein [18]. Estrogens also play an important role in the regulation of the vascular endothelium where they activate rapid vasodilatation, exert anti-inflammatory effects, stimulate endothelial growth and migration, and protect the vessels from atherosclerotic degeneration by elevating nitric oxide and prostaglandin levels [19,20]. Aromatase is a potentially important factor in these processes as it controls estrogen biosynthesis and is expressed in regions of the brain affected by AD [21,22,23,24]. Previous studies have demonstrated that common CYP19 polymorphisms are associated with estradiol and androgen serum levels in premenopausal and postmenopausal women [25,26,27,28]. As a result, CYP19 gene variants could potentially affect risk for AD by reducing or increasing the rate of conversion of androgens into estrogens, resulting in altered protection against neuronal injury or degeneration through multiple mechanisms.
Differential association of polymorphisms in a susceptibility gene for AD in groups of disparate population ancestries may occur for several reasons. First, differences in LD patterns between ethnic groups may contribute to discrepancies in genotype associations (online suppl. fig. 1-3). In our cohort, SNPs which were protective against AD in women of predominantly Caucasian AIMs-defined ancestry were located at the 5′ end of the gene (online suppl. fig. 1, block 2), and those which increased risk for AD in this population clustered in two LD blocks at the 3′ end of the gene (online suppl. fig. 1, blocks 5-6). Notably, these LD blocks which remained cohesive in women of predominantly Caucasian ancestry were represented by smaller sets of SNPs in women of admixed/Hispanic AIMs-defined ancestry (online suppl. fig. 2). LD blocks in this region were even more fragmented among women of predominantly African AIMs-defined ancestry (online suppl. fig. 3). This suggests that different LD patterns between CYP19 alleles and alleles of as yet unidentified loci for susceptibility to AD between populations of different genetic ancestries may contribute to the observed variability in genotypic association.
Second, it is also possible that differences in environmental or biological risk factors among women of different genetic ancestry may play a significant role in phenotypic expression of the variants. For example, the inclusion of vascular risk factors (including history of diabetes and current smoking) attenuated the significance of SNPs in women of admixed/Hispanic (online suppl. fig. 5) or predominantly African AIMs-based ancestry (online suppl. fig. 6). In contrast, the inclusion of these vascular risk factor covariates increased the significance of several SNPs in women of predominantly Caucasian AIMs-defined ancestry, notably in SNPs located at the 3′ end of the gene (online suppl. fig. 4). The potential mediation of SNP effect by vascular risk factors is reinforced by the differential results seen in the logistic regression analyses stratified by self-identified ethnicity versus AIMs-defined ancestry. As seen in table 2, the change in stratification had the greatest effect on sample group characteristics and size when comparing self-identified Whites versus individuals of predominantly Caucasian AIMs-based ancestry, and self-identified Blacks versus women of predominantly African AIMs-based ancestry. Specifically, the shift in classification of race revealed that many individuals who had genetic markers that were predominantly Caucasian or African actually identified themselves as Hispanic. These individuals also had significantly higher rates of diabetes mellitus (online suppl. fig. 7) than individuals of predominantly African AIMs who identified themselves as Black or participants of predominantly Caucasian AIMs who identified themselves as White. Notably, when these individuals were included in the AIMs-based logistic regression models for participants of predominantly Caucasian or African ancestry, several SNPs at the 3′ end of the gene became significant (table 3), again highlighting the potential mediation of SNP effect by vascular risk factors in this part of CYP19. These discrepancies indicate that environmental and biological covariate risk factors may exert different modulating effects with alleles in groups of different predominant genetic ancestries, or even within different parts of the gene.
Several previous studies have investigated the role of CYP19 polymorphisms and AD. A study of a Finnish population found 3 SNPs (rs767199, rs727479 and 1065778) to be associated with increased risk for AD, as well as haplotype A1 (CACTTTGTT) [5]. Other SNPs including rs2899472, rs1008805, rs727479, rs1143704, rs1065778, rs10046 and rs4646 have also been found to be associated with risk for AD or age at onset (some in APOE ɛ4 carriers only) [4,6] in primarily Caucasian populations. In other studies, an interaction between rs1062033 (located in the 5′-UTR region) and the genes for butyrylcholinesterase [29] and interleukin-10 [30] in increasing risk for AD was proposed. In addition, rs2899472 was found to be associated with CSF Aβ1-42 levels in normal subjects in a GWAS investigation [31].
We examined the majority of the SNPs cited in the above studies. While rs727479 was protective among self-defined Whites in our group, we did not find any other SNPs to be significant. Although many of these previously evaluated SNPs are clustered at the 5′ end of the gene, in LD blocks 1 and 2 by our map (online suppl. fig. 1), many of the SNPs which we found to be significant in our participants of predominantly Caucasian AIMs-defined ancestry clustered at the 3′ end, in LD blocks 5-7. However, as previously noted, most previous studies were conducted in self-identified White participants who may have had different associated risk factors from our Caucasian population, which also included individuals who identified themselves as Hispanic.
Overall, our findings confirm the findings of previous studies of a strong association between CYP19 polymorphisms and risk for Alzheimer's disease among women. We also extend these studies through denser genotyping, rather than relying on imputation which can introduce false positives in multiethnic cohorts. From this effort, we identified additional SNPs that are associated with AD risk, and characterized how these SNPs vary among individuals of different AIMs-defined ancestries in the presence of cardiovascular risk factors. Moreover, our study illustrates the importance of controlling for population stratification as well as for environmental risk factors in association studies, as SNPs which we found to be associated with AD varied significantly between ethnic groups.
We note that most SNPs examined were intronic, and therefore may not be the critical location of the pathological variants, but may serve as markers for the critical region or may otherwise influence the expression of critical genetic markers. Further studies may characterize other genetic mechanisms that may contribute to AD, including methylation and copy number variations. For example, SNP 27 (rs17647719) is located in a region associated with methylation, and SNP 28 (rs1902586) is located 2.6 kb from this region. Future studies with denser genotyping to achieve high resolution in all ethnic groups, along with gene expression studies, may further provide biological insights. Additional insight may also be gained through future studies conducting similar analyses in men.
This study was supported by Alzheimer's Association grant IIRG-08-90655, 'Genetics of Estrogen and Alzheimer's Disease in a Multiethnic Cohort' (N. Schupf) and National Institute on Aging funded grants P01AG007232 (R. Mayeux) and R01AG037212 (R. Mayeux and N. Schupf).
Dr. Janicki, author, is funded by NIH grant 5-T32MH020004-1, the Charles and Ann Lee Saunders Brown Fellowship Fund, and the Louis V. Gerstner Jr. Scholars Foundation. Dr. Janicki reported no biomedical financial interests or potential conflicts of interest.
Ms. Park, author, is funded by 5P01 HD035897, R01 MH084995 and R01 NS060113. Ms. Park reported no biomedical financial interests or potential conflicts of interest.
Dr. Cheng, author, is funded by NIH grants U24 AG026395, R01 AG028786, R01 NS060113, R01 MH084995, R01 AG036469 and P50 AG008702. Dr. Cheng reported no biomedical financial interests or potential conflicts of interest.
Dr. Schupf, author, is funded by NIH grants 5R01AG014673-09, R01AG037212, U01 AG023749, R01 AG028786, P01 HD35897, P50 AG08702, R01 AG034189, 1 R21CA125461-01A2, 1 R01AG034189, 1 R01AG0306040-01 and 5R01AG007370-17, and receives research support from the Alzheimer's Association. Dr. Schupf has consulted for Elan/Jannsen Pharmaceuticals.
Dr. Clark, author, is funded by NIH grants R01 NS060113, R01 NS073872, 5 P50 AG008702, 1RC2NS070276 and 2P50NS038370-11, the NINDS Parkinson's Disease iPS Cell Line Research Consortium and P50 'Genetics of Down Syndrome', and receives research support from the Alzheimer's Association, the Parkinson's Disease Foundation and the Michael J. Fox Foundation. Dr. Clark reported no biomedical financial interests or potential conflicts of interest.
Dr. Lee, author, is funded by NIH grants R37 AG15473, U24 AG026395, 5P01 HD035897, R01 MH084995, R01 AG028786, U01 AG023749, R01 NS060113 and R01 AG036469, and receives research support from the Alzheimer's Association. Dr. Lee reported no biomedical financial interests or potential conflicts of interest.
Sarah C. Janicki, MD, MPH
Gertrude H. Sergievsky Center, Columbia University Medical Center
P&S Box 16, 622 West 168th Street
New York, NY 10032 (USA)
E-Mail firstname.lastname@example.com
Accepted: August 27, 2012
Published online: April 18, 2013
Issue release date: May 2013
Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 3
ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)
For additional information: http://www.karger.com/DEM
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
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subset: commoncrawl


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Britney Spears must really want to sell some albums. The performer, whose latest —
"Femme Fatale" — just dropped, performed on "Jimmy Kimmel Live" Tuesday (March 29) evening.
But the highlight of the show was a supposed outtake from "Jackass 3-D" brought to the show by guest Johnny Knoxville. In it, Spears appears to step up for one of the crew's signature stunts, the "Poo Cocktail Supreme."
For those of you who haven't seen the movie, we'll describe it before you press play below. In the stunt, a volunteer is locked inside a port-a-potty which is attached — by bungee cord — to a crane. Volunteer inside, the crew releases the bungee, causing the port-a-potty to vault into the air and bounce. And bounce. And bounce. The contents of the tank are, of course, thrown all over the volunteer.
In the original movie, Steve-O ended up covered in unmentionable filth, inspiring some of his grossout buddies to vomit. Britney, on the other hand, seems to have escaped with only a little blue liquid splattered into her weave.


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After heading down to Bangalore, India for its first DIY project, Levi's Skateboarding continues its philanthropic expeditions in La Paz, Bolivia. With the help of Bolivian skater and tour guide Milton Arellano, Marius Syvanen, Josh Matthews, Joey Pepper, and a slew of other professionals donned hardhats to help construct a massive park in Bolivia's third-largest city. As Arellano notes in the video, it's certainly refreshing to see an international community – one so frequently written off for destructive tendencies – band together to create a positive space for others. Watch as Levi's Skateboarding immerses viewers in the culture and lifestyle of La Paz, Bolivia, then head over to the brand's website for more information.


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BD Podcast: 2011 Week 4
Brutal Deluxe Football Podcast Season 8 Show 4: 2011 Week 4. Scott Buffington and Alex Harden review Week 4 in the BDFL and NFL, look ahead to Week 5, and talk about football news.
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firstname.lastname@example.com wrote:
> Pat,
> That is what I thought. Where is it all going to?
Well, the weathermen say it's because El Nino pushes the jet stream
south of us - thus missing what Canada normally dumps on us. The
weird thing is, North, South, East and West of us there is snow - just
not us!
We did get one inch of snow today - wheee. But one inch isn't going
to make up for the drying cold weather we've had since October.
Pat Mitchell
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Martin Bruch eBooks
eBooks found: 1
Biblical References in Thomas King's 'Green Grass, Running Water'
Martin Bruch
GRIN Verlag, January 2010
Format: PDF
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Product Details
- Quality German engineering ensures precision, durability and silent operation
- Designed to shred between 2,000 and 8,000 sheets per day. The 41522 offers quick and easy destruction of confidential materials.
- 12" Feed opening for easy shredding of letter and legal sized paper
- Shreds Staples, Paperclips, Credit Cards, and CDs/DVDs
- CleanTEC Filtration eliminates up to 98% of the fine dust particles produced, providing improved air quality and promoting a healthier work environment
- Safe Technology offers revolutionary Verbal and Contact Emergency Shutdown System. In an emergency, simply yell "Stop" or tap the top cover for immediate shutdown.
- SmartPower multi-stage energy management system reduces power consumption when sitting idle
- Rubber Shock Mounts between cutting mechanism and wooden cabinet reduces vibration to provide extremely quiet operation
- Thermally Protected Motor prevents overheating during constant shredding
- ESP Protection lets shredder know how much you're shredding to prevent overfilling shredder bin capacity
- 38 gallon waste compartment is able to hold large volumes of waste requiring less frequent changing
- Solid cutting head of German steel is milled to create each cutting cylinder
- Wooden Cabinet blends in with any office decor and deafens noise for quiet operation
- EvenFlow Lubricator automatic oiler provides continuous lubrication across the entire cutting mechanism
- Utilizes gussetted waste bags that expand to collect a larger amount of material
- Shred Size: 1/12" x 9/16" Cross Cut
- Security Level: P-5 (Old Level 4)
- Feed Width: 12"
- Capacity: 11 Sheets
- Speed: 16 ft/min
- Motor: 1.2 Hp 115V
- Waste Bin: 38 Gal
- Waste Bag: 706
- Weight: 132 lbs
- Dimensions: 34 1/2" x 29" x 20"
- Warranty: Lifetime Manufacturer Warranty on Cutting Cylinders, 2 Year on Parts and Labor
If you hold the forward button for a few seconds it will go into continuous feeding mode.
So now feed stack after stack until you're finished.
Without doing this it will automatically start and stop the motor when you insert you pages.
The opening is 12" inches wide, which will fit the full length of a standard page.
And it senses if you've put in too many pages, to which the motor won't start until there's less.
If you need to ever stop shredding—like if you catch your hair or tie…ouch—hold the reverse b... Read More
This is the Dahle Level P-5 41522 Small Department Shredder!
If you hold the forward button for a few seconds it will go into continuous feeding mode.
So now feed stack after stack until you're finished.
Without doing this it will automatically start and stop the motor when you insert you pages.
The opening is 12" inches wide, which will fit the full length of a standard page.
And it senses if you've put in too many pages, to which the motor won't start until there's less.
If you need to ever stop shredding—like if you catch your hair or tie…ouch—hold the reverse button and pull everything out.
Of course you can always panic and shout! And the shredder will stop! That's because right in this corner is a microphone, which is a very unique safety feature.
And you don't have to worry about staples and paper clips, it'll shred those too.
For how surprisingly small it is, the security level is only mid-range right below super duper high security and Top Secret!
Opening the bin we see a spot to store a bottle of oil.
And it will tell you when it needs more oil, which then you can fill the automatic oiler and keep your machine working smoothly.
And pulling out the bag and replacing it is simple. Just wrap the bag around the square bar, then slip it into place.
Place the black tray in the center to catch CD trimmings. Slip your CDs in the front slot and push the forward button. CDs are not recyclable, that's why it's good to separate them.
On the back is a dust filter—if you've ever shredded a lot of pages without one, you'll know how much fine dust is actually released—but not anymore with a filtration system!
The automatic power features put it in sleep mode after 10 minutes of inactivity and shuts it off after 30.
When you find a good spot to put your shredder, lock the wheels so it stays there.
Here is a list of accessories for Dahle shredders.
Dahle CleanTEC 41522 Paper Shredder Review
- Have you been looking for a new paper shredder for your office? If so, we think you should consider looking at the Dahle CleanTEC 41522, a shredder that's new to the market. We had a chance to try this machine out, so here's what we discovered about its strengths and weaknesses:
Features/ Strengths:
- The 41522 is a cross-cut shredder that comes with a Level 4 security rating. It will give you a terrific amount of protection so you can safely shred confidential documents that contain Social Security numbers, banking information, and so on.
- This machine can accommodate paper that's up to 12" wide. You can shred up to 13 sheets at a time which adds up to about 16 feet of paper per minute. The sheets can even have paper clips and staples still attached to them. Also, you can use this device to shred debit/credit cards and CD's and DVD's. All in all, it's very versatile.
- The 41522 was designed for smaller offices and because of this, it has a 38-gallon waste bin. The machine operates quietly to ensure that the people in your office won't be distracted when someone is shredding.
- This is one of the shredders in Dahle's CleanTEC series. Each machine has a unique CleanTEC filtration system that keeps paper dust from getting into the air so you and your colleagues can stay as healthy as possible.
- This machine has a really unique safety feature. If you yell
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Capital Benefits Llc, Insurance Consultants, listed under "Insurance Consultants" category, is located at 363 Rte 46 W Fairfield NJ, 07004 and can be reached by 9738082626 phone number. Capital Benefits Llc has currently 0 reviews.This business profile is not yet claimed, and if you are the owner, claim your business profile for free. If you are not the owner you can invite this business to join by email or by phone.Browse all Insurance Consultants in Fairfield NJ. Discover census data for Fairfield, NJ.
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Megan-39, Postpartum Doula, DW to Sacha-40 (18 years together) and Mama to Finn Alexander born 4/2/07 and Zivia Littlewood born 8/23/10
Reading this reminded me of my first REAL pregnancy craving - at 2 a.m. at about 20 weeks I woke up and had to go to the grocery store, get ingredients and make myself SPAM Musubi. Damn, if I were not currently suffering from the stomach flu I'd go get some now!
Thanks for the smile.
After getting my wife's blood tests back, we had a few moments when we questioned the possibility of twins, but realized it was really, really unlikely. Though, we thought it would be hilarious to tell people that I was part of the reason she had twins.
You would be *amazed* by how many people conclude that we had twins due to Lena's being a twin.
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Football Italia would like to wish Juventus captain Alessandro Del Piero a very happy 36th birthday.
The talismanic striker has enjoyed a great start of the season, overtaking Giampiero Boniperti as Juventus' all-time top goal scorer in Serie A.
Del Piero has found the net six times in 18 appearances this season and is practically an ever present under new boss Gigi Del Neri.
This is his 18th season at the club and needless to say Del Piero has won every major honour in the game from the Champions League and the Scudetto to the Coppa Italia and Intercontinental Cup.
Keep up to date with the latest news and action from Spain's Primera Division with Football Espana - from the team behind Football Italia.


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Richard Rawlings net worth: Richard Rawlings is an American car builder, cross-country racer, and reality television personality who has a net worth of $15 million dollars. Born in Fort Worth, Texas, Richard Rawlings began building cars and going to car shows with his father when he was a young child. He began buying his own cars when he was 14. His first car was a 1974 green Mercury Comet. By the time he was actually old enough to drive, Richard had already bought and sold several cars. In high school he drove a 1977 Bandit Trans Am. After high school, Rawlings set out to work various jobs that would help support his passion for cars. He went on to work as a firefighter, paramedic, police officer, and finally, owner and operator of his own printing and advertising company. He sold his printing company in order to launch Gas Monkey Garage in Dallas, Texas. Gas Monkey Garage has since become a world-famous hot rod shop with clients coming from all over the world. Gas Monkey, and the various cars that Rawlings finds, buys, or is given to restore, are now the subject of the hit Discovery Channel series, "Fast N' Loud". The show began airing in June of 2012 and has since produced four seasons. The show features Mr. Rawlings, and his co-workers, Aaron Kaufman, KC Mathieu, and Scot McMillan as they seek out rare automobiles and restore them for a profit. According to legend, in the 1990s Richard took a bullet when he came across a carjacker attempting to steal his 1965 Mustang 2+2. Richard Rawlings is also a passionate transcontinental racer. He has participated in several rallies. He once held the world record for fastest time in the Cannonball Run, until his score was eclipsed in 2013. To break that record, which had stood since 1979, Rawlings traveled 2811 miles from New York to Los Angeles in 31 hours and 59 minutes. That equates to an average driving speed of 87.6 MPH. He has also won both the Gumball 3000 and The Bullrun an unprecedented two times a piece.
Richard Rawlings Net Worth
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All net worths are calculated by applying a proprietary algorithm. The results are then fact checked and confirmed by a team of editors. We scan all publicly available data and resources and work diligently to ensure that our numbers are the most accurate and up to date net worth data you will find anywhere on the internet.


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: G.SKILL Ripjaws X Series 8GB (2 x 4GB) 240-Pin DDR3 SDRAM DDR3 2133 (PC3 17000) Desktop Memory Model F3-17000CL11D-8GBXL
Pros: Extremely well designed RAM! I was pairing these sticks with an i5 and one needs to becareful as Intel wants lower voltage than many of these higher RAM sticks. However these sticks work great. Also the iSeries from Intel doesn't support faster than around 1600. I wanted to future proof some and so I grabbed these faster sticks as a just in case. So to confirm these work great for Haswell iSeries CPUs.
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This review is from: ASUS RT-N10P Wireless N150 Router IEEE 802.3/3u, IEEE 802.11b/g/n
Pros: While this unit isn't the most powerful on the market it is very stable and handles multiple devices (wired and wireless) together with ease. It is rare I have to restart this device as it just quietly keeps our Internet connection stable and going.
The wireless range is pretty good for a single antenna unit. So for my physical footprint (multi-story detached single family home) I can access the Internet from anywhere in my house and even outside.
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This review is from: LG Internal 24x Super Multi with M-DISC Support SATA Model GH24NSC0B
Pros: This is an inexpensive well built DVD burner. It does what it says it does and just works while being easy to install. Plus it matches my black G41 case. What more can you ask from this type of component?
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Other Thoughts: An awesome optical drive that is well made and low cost. What more is there to say?READ FULL REVIEW


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Woman's Picture (2011)
Plot Summary
Woman's Picture is an anthology film inspired by classic women's films of the thirties, forties, and fifties. The story is divided into three sections, each of which deals with its own specific female character. The segments function as parallel dimensions, exploring thematic connections between women whose immediate experiences seem very far removed from one another.- Written by Anonymous
Be the first to contribute! Just click the "Edit page" button at the bottom of the page or learn more in the Synopsis submission guide.


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A stunning brand new three bedroom apartment, wonderfully located in this historic central location. This property is finished to the highest specification, including beautifully designed marble bathrooms, electric blinds, mood lighting settings and a stylish furniture
A superbly presented three bedroom apartment in this popular and beautiful development, located moments from Fleet Street and the River Thames. Benefits from two recently upgraded high specification bathrooms and daytime concierge.
Due to the fast moving pace of the Short Let market, many of our properties never make it to the website. If you can't find what you're looking for, please give our Short Let team a call as we may have the ideal property for you.


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Our increased dependence on complex information systems and ever-growing numbers of network endpoints, make the role of IT first responders a critical one. More work is being demanded of fewer, often less skilled, network and PC technicians. The sprawl of their networks across metros, regions, and even the globe adds to the difficulties of keeping systems running. This reliance on the connected world demands that frontline personnel keep networks running, whether troubleshooting an end user's problem, setting up new cubicles, or deploying new technology, such as VoIP, IP surveillance or Wi-Fi. Continuous advances in networking technologies—from health care to government, energy to education—depend on the ability to share and grow ever bigger ideas more and more quickly. Download whitepaper »
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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: LG 60" 1080p 600Hz Plasma HDTV 60PZ550
Pros: its newegg
Cons: the shipping is terrible it took 2 weeks to get to me and i had to end up calling the shipping company and all that they told me was "we didnt have your number so we couldnt set up an appointment" absolutely terrible shipping company choice newegg. I love your site and will continue to buy small stuff but will never order freight sized items again if you stay with the same company
Other Thoughts: this rating is not twards the product itselfREAD FULL REVIEW
This review is from: ASRock P45XE-WiFiN LGA 775 Intel P45 ATX Intel Motherboard
Pros: does what I need. able to adhoc 2 computers and still have internet.
Cons: Intel Core 2 Quad Q9650 + 8gig of corsair dominator memory = FAIL.
would not run with all the memory at the recomended speed of 1066. just could not take it. blue screen everytime.
Other Thoughts: great motherboard but not for high performance.READ FULL REVIEW
This review is from: Patriot Xporter XT Boost 8GB Flash Drive (USB 2.0 Portable) Model PEF8GUSB
Pros: great product! extreamly fast
Cons: bought this with the egg saver shipping and it should have been here within 7 days but it took almost 2 weeks. if i knew that it was comming snail mail i would have just paid the 4 dollars and sent it with UPS. slow packages is not like newegg!!READ FULL REVIEW


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Speculators More Bullish on Oil
October 17, 2016 2:15 AM Bloomberg Video
Oct. 17 -- Money managers are the most bullish on crude in two years as OPEC prepares to parcel out its first output cut in almost a decade. Bloomberg's Tracy Alloway reports on "Bloomberg Markets: Middle East."
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Terrence Malick Speaks
After winning the top prize at Cannes this weekend, it looks like we have our strongest Best Foreign Oscar contender and now, we know when we'll be able to see it. We praised Michael Haneke's drama Amour at the festival, giving it an A and calling it "a heart-wrenching and unflinching portrait of an elderly couple faced with the trials and tribulations of our own mortality when confronted with the inevitable demise we all face."
Sony Pictures Classics, who distributed Haneke's last film and Palme d'Or winner The White Ribbon, have now set a December 19th, 2012 limited release for the film that is certainly expected on the fall festival circuit. This couldn't be a more prime date with Oscars in mind. So for those that want a little death for Christmas and are tired of hobbits, this one is for you.
Are you looking forward to seeing Haneke's next film?
Since any New York City cinephile has a nearly suffocating wealth of theatrical options, we figured it'd be best to compile some of the more worthwhile repertory showings into one handy list. Displayed below are a few of the city's most reliable theaters and links to screenings of their weekend offerings — films you're not […]
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New York State Senator Mark Grisanti has been selected by the American Society for the Prevention of Cruelty to Animals to receive the organization's coveted Humane Leadership Award at its annual "Voices For Animals" Day. For more information, please visit www.senatormarkgrisanti.com/?p=6332
Says proud of role Clerk's office plays to support critical services while keeping down taxes
Erie County, NY – Erie County Clerk Chris Jacobs reported today that his office accounted for 50% of the overall county surplus. Jacobs' is referring to the County Comptroller's report released yesterday which shows an overall budget surplus of $4.27 Million, and "roughly 50% of the county's entire operating surplus," came from the County Clerk said the Erie County Comptroller in his budget close-out report.
"We were proud to report our over $2 million dollar surplus several months ago but the fact that we contributed such a large percentage to the County's overall surplus is quite significant," said Jacobs. The Clerk's Office represents only 4% of the County's work force but is responsible for one-half of the 2012 County's surplus.
Senator Mark Grisanti (R, I-60) recently received the prestigious 2013 Liberty Bell Award, the highest award that is bestowed at the Annual Law Day Luncheon of the Bar Association of Erie County.
The award, established in 1964, recognizes community service that has strengthened the American system of freedom under the law and acknowledges outstanding contributions to the effective functioning of our institutions of government.
The award was presented to Senator Grisanti at a luncheon held at Statler Towers in the City of Buffalo. Receiving the award in his absence (Session Day in Albany) was his father, Richard Grisanti, who has been practicing law for over 50 years.
Senator Mark Grisanti (R, I-60) recently announced the appointment of Ric Dimpfl as his fire, EMS and emergency services liaison for the Southtowns portion of the 60th New York State Senate District.
A Village of Hamburg resident, Dimpfl served in a similar capacity in the past for two former New York State assemblymen who also represented the Southtowns region of Western New York."Ric is the ideal person to fill this volunteer role for me by serving as my liaison to all of the volunteer fire companies and other emergency response organizations based in the Southtowns," says Senator Grisanti. "Ric knows the area and will work closely with me and my staff in my district office in Buffalo to make sure an ongoing dialogue continues so I can better understand the needs of the many dedicated men and women who volunteer their time and skills to provide our community with quality public safety."
A member of the staff of New York State Senator Mark Grisanti will hold satellite office hours at Hamburg Town Hall, 6100 South Park Avenue, starting this month.
The staffer will be present to answer any questions or address any concerns that constituents may have about state-related issues.
"These town hall meetings will help establish easy and efficient communication between our office and our constituents," said Senator Grisanti. "At no cost to the taxpayer, state government will be able to come to you."
In addition to Hamburg, the visits will be happening aross the senator's district in the town halls of Orchard Park, Tonawanda, Brant, Evans, Grand Island and the City of Tonawanda.
Grisanti's staff will have available to the public various forms, informational brochures and contact information for constituents.
Dates that Senator Grisanti's staff will be at Hamburg Town Hall from 10 a.m. to 2 p.m. are below:
Senator Grisanti-(R,I-60) is the co-sponsor of S.2755 which would allow professional Mixed Martial Arts(MMA) events to be held within New York State. The bill passed the Senate by a margin of 47 to 15.
MMA is legal in 47 states and has a huge following based on attendance and pay per view sales alone.
The success of the UFC (Ultimate Fighting Championship), the premier MMA League, has brought economic benefits to cities around the country and the globe.
An exhibition in Toronto last spring set a record of $11 million in ticket sales alone with over 50,000 tickets sold. The total impact from weigh-in on Friday until the end of events on Sunday was $35 million.
An independent study done a couple of years ago indicated that Buffalo could reap almost $5 million from one exhibition.
New York State Senator Mark Grisanti (R,I,-60) recently announced that the New York State Senate has voted to pass Bill S.1590, which makes it a crime to conceal a death by knowingly moving or otherwise hiding a human corpse so that discovery of the death will be hindered.
The bill is sponsored by Senator Grisanti and Amanda Lynn's Law has passed the Senate the past two years. It will now be sent to the Assembly.
Lancaster Historical Society Museum
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Kleinhans Music Hall
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Ratings based on 366 Verified Reviews
4.0 Room cleanliness
4.0 Service & staff
4.2 Room comfort
3.9 Hotel condition
Expedia Verified Reviews
for Everyoneby A verified traveler
HPosted Dec 8, 2016
I did not like I did not get 2 beds in my room which I requested and paid for in the summer And we are put in old building The serving staff are very slow But I do like your facility
for Everyoneby A verified traveler
Two Thumbs Up!Posted Oct 5, 2016
Just returned from the Westin St. John. Spent 12 days there for our honeymoon. Parts of the facility are undergoing renovations as they move towards conversion to time share. However, the work was confined to two buildings and the rest of the facility was in very good shape. From the time we arrived to departure the staff was very friendly and accommodating. The room was exactly what we requested and we had no unexpected surprises while we were there. Everything was very clean and well maintained. The staff worked with us to set up any trips and/or car rentals and made sure that we were satisfied with their service. Hope to be able to return once all of the updates are finished.
for Everyoneby A verified traveler from Chicago, IL
Great place on St JohnPosted Sep 22, 2016
Very nice hotel on St. John. Stayed in beachfront room 1013. It had a beautiful view of the beach only a few feet away. Comfortable room although slightly outdated. They are remodeling all of the rooms as the property appears to be going all timeshare. Would definitely stay there again.
for Everyoneby A verified traveler from Ohio
The resort is nice but not so the staffPosted Sep 2, 2016
Pros: Great location which is convenient to Cruz Bay
Cons: The staff was not frinedly and disinterested in guests. For a tropical resort free bottled water should have been given.
Location: St John's is a wonderful destination and we would return.
The resort is very nice but undergoing renovation to a timeshare property. The rooms are comfortable.
by A verified traveler from New York, NY
Will never stay at another Westin resort againPosted Aug 31, 2016
Pros: The only good thing about this place is the pool and fact that we could walk to it through the backdoor of our room.
Cons: Pretty much everything, especially customer service since we had several issues with that on our trip.
Location: Beaches in the National park are the best thing about this place don't bother with anything in the resort not worth the time or money.
A reviewer had mentioned that this hotel had 3 star service with 5 star prices wish we has listened to them & taken our business elsewhere because that is exactly what we got maybe even worse.To start we asked for a double queen bed & were given a king bed instead which meant no room for one of us to sleep since we were traveling with our 3yr old. When I called & pointed this out to customer service they said they couldn't do anything but could rent us a roll away bed for $5 a day. When I asked why do we have to pay for it when it's not our fault they decided it wasn't their problem so we had to suck it up & just pay for it otherwise one of us would have been on the floor. On top of all this our room had mold growing on the ceiling by the AC vent Room1114. 2nd day of our stay we wanted to order room service but couldn't find a menu in the room. Turns out we had to request it from customer service & then make the order which seemed odd. Next the food,the hotel only has 1 sitdown restaurant called Lemongrass which is where our room service food was from. You had to order the food before 9:30pm otherwise we couldn't order from there which also meant less selection on the menu. When the food came it was cold & barely edible.Next day onwards we ended up getting sandwiches & deli meat from the nearby supermarket. To top it all today I found out they charged us 2x for all room charges which they refused to admit when I called to explain this to them. Just placed dispute with my cc.
for Everyoneby A verified traveler from Minnesota
Nice hotel, great for familiesPosted Aug 29, 2016
Pros: Amenities
Cons: Dining options
Location: Great location on St. John. Close to Cruz Bay and the beaches. Our room was by the pool which was centrally located.
The hotel property is very large and there is a lot to do with the pool and beach activities. We decided to explore the park beaches on St Johns which were fabulous. We rented a Jeep at the hotel and the car rental staff was friendly and very helpful. The only downside was the lack of restaurant options at the resort. We went off the resort to eat because we had already exhausted the options on site. Cruz Bay is close and has a lot of dining options but the taxi ride can be expensive.
by A verified traveler from chicago
Hotel needs major renovation.Posted Aug 22, 2016
Beautiful grounds but everything needs remodeling. Staff is awful. Great pool which also needs rehab. Not worth $
for Everyoneby A verified traveler
Westin st johnPosted Jul 8, 2016
The Westin has a nice lounge at the airport in st Thomas. This is where you will schedule your ferry transportation to St. John. While it is very convenient and efficient, it costs $120 per person for "unlimited ferry rides" to and from St Thomas. My wife and I found no reason to go back to St Thomas until we needed to fly back home. Public ferry to St. John is $6 or $7 per person. You will need a cab to get to the ferry in st Thomas and another cab to get from the ferry dock in St. John to the Westin but you could save some serious money by doing this work yourself. Cab approx $10-20 plus ferry 7 + 7 = $34 (worse case) each way. So $64 versus $240 for Westin to take care of it for you. After you get to the Westin they have free rum punch waiting for you! The resort is fabulous. Without a question the best resort on the island. Staff is top notch, as are facilities. Fine dining and casual dining are available, poolside bar, free kayaks, paddle boards , floats, and a beautiful beach! I wouldn't hesitate to recommend the Westin. The Marriot has recently purchased the Westin and the resort is going timeshare/ condo so I'm not certain how much longer "hotel rooms" will be available.
for Everyoneby A verified traveler
Posted Jul 5, 2016
Family of four had a great time. Staff was excellent. Pool was great. Beach was awesome. Water sports rentals were great.
for Everyoneby A verified traveler from L
Very relaxing and quiet hotel on beachPosted Apr 25, 2016
The hotel staff here are exceptional. The hotel has a great pool and is right on the beach with a great swimming area. They have a restaurant bar right on the beach.


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Autocad Structural Engineering Plans Help!!!
- Status Closed
- Budget $30 - $50 USD
- Total Bids 2
Project Description
What is basically needed are a set of drawings drawn in Autocad 2006. These drawings are based on the high-rise building which is provided in the zip file attachment.
The structural plans required are:
*footing layout
*top reinforcement
*bottom reinforcement
These are to be drawn using Autocad LT 2006 on a scale of 1:100
Also required are drawings outlining sections and details of:
These are to be drawn using Autocad LT 2006 on a scale of 1:20
Also included are templates in which to work off. In terms of reinforcement which is to be used for the drawings, these can be assumed or kept consistent with what is shown in the template Autocad files provided.
## Deliverables
1) All deliverables will be considered "work made for hire" under U.S. Copyright law. Buyer will receive exclusive and complete copyrights to all work purchased. (No 3rd party components unless all copyright ramifications are explained AND AGREED TO by the buyer on the site per the worker's Worker Legal Agreement).
## Platform
The format is as follows:
All drawings are to be drawn using Autocad LT 2006.
Drawings must include title blocks and boarders
Different line-types and line-weights shall be used in the drawings
Grids shall be consistent with the Architectural concept drawings that you have been given
Drawings shall contain sufficient dimensions for construction
Only standardized symbol shall be used in your drawings
Correct scales shall apply to the plots of your drawings
Title blocks must be inserted in paper spaceGet free quotes for a project like this
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Tag Archives: Steve Chen
Call for proposals: CPRsouth 2017. For more details see announcement.
Work with us: We are currently recruiting for the position of Big Data Researcher.
YouTube has 1 billion visitors worldwide (Excluding Bangladesh)
YouTube has hit a billion regular monthly visitors. Such milestone, also reached by Facebook last October, further solidifies Cisco's projected dominance of video in the cyberspace. "If YouTube were a country, we'd be the third largest in the world after China and India," the company said in a blogpost announcing it now has a billion […]
Wikipedia, SMS and You Tube among best innovations recognized by 'The Economist'
The Economist annual prizes recognise successful innovators in eight categories. Here are this year's winners: Bioscience: Martin Evans, director of the school of biosciences and professor of mammalian genetics at Cardiff University, for his work in stem-cell research and the development of "knockout" mice. Sir Martin performed pioneering research into stem cells, and used them […]


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Catalog #: 72517.6000
Xenon Part #: 5860
Xenons award winning design is complemented
by a fit and finish that is second to none. Each component is styled to fit your vehicle with OEM
precision. Easily prepped for paint, each component comes complete with installation instructions and hardware. Xenons Limited Lifetime Warranty covers every urethane kit, flare, and component.
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Lent begins tomorrow! Sign up for one of our Easter devotions.
25:1–7 Just as man needed a day of rest, land without fertilizers needed to lie fallow for a time. See the similar regulations in Ex. 23:10, 11.
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Alternative Titles
Synonyms: Hidamari Sketch: Tokubetsu Hen - Zengo Hen
Japanese: ひだまりスケッチ 特別編 前後編
Type: Special
Episodes: 2
Status: Finished Airing
Aired: Oct 18, 2007
Producers: Lantis
Licensors: Sentai Filmworks
Studios: Shaft
Source: 4-koma manga
Genres: Comedy, School, Slice of Life
Duration: 24 min. per ep.
Rating: PG-13 - Teens 13 or older
Score: 7.611 (scored by 7,768 users)
1 indicates a weighted score. Please note that 'Not yet aired' titles are excluded.
Ranked: #12742
2 based on the top anime page. Please note that 'Not yet aired' and 'R18+' titles are excluded.
Popularity: #2689
Members: 13,535
Favorites: 7


text:
In the rain,
for it happened when,
a change occured,
such a rarity then.
I never saw it coming,
it took me by surprise.
My heart had been re-opened,
my mind had been revised.
I no longer craved to quit,
no longer could give up.
I had to fight this thing.
My mind had been made up.
My make up, it was running.
My hair was dripping wet.
I didn't even care.
My sould and heart had met.
© Copyright 2017 DarlingDontDare. All rights reserved.
Status: Finished
Genre: Poetry
Thank you so much! i absolutely will! =D
Book / Young Adult
Short Story / Romance
Short Story / Romance
Shelves: 7
Paste the link to picture in the entry below:
Paste the link to Youtube video in the following entry:
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More Videos...
Mustang vs G35
see, Mustangs are faster. and for less than half the price
G35 coupe vs Ford Mustang 4.6 roll-on
G35 coupe vs Ford Mustang 4.6 roll-on
G35 Coupe vs 350z
'04 G35 Coupe with CAI, 6 speed vs '04 350z with K&N filter, and full Borla Exhaust and headers, also a 6 speed. 2nd and 1st gear rolls.
06 G35 vs Gt mustang
My g35 vs a buddies Mustang... (1st run) G35 is 2006 bone stock, auto. Mustang is a 2004 GT with intake/Exhaust/headers, manual. My 2006 ran- Reaction Time- .027 60'-2.295 1/8th-9.550 1/4- 14.838 @ 89.63 The Gt stang ran- Reaction Time- .225 60'-2.330 1/8th-10.140 1/4- 15.452 @ 94.44


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Some $300 billion will be invested in bond funds this year, more than the totals posted for 2010 and 2011, according to Strategic Insight. Fixed-income investments, however, are viewed as increasingly risky, says Michael Gitlin, director of fixed income at T. Rowe Price Group. Yields have become too low for the credit risks, he says.
Full Story:InvestmentNews (free registration)


text:
Pesto Beef Swirls
|Steak sauce
|1⁄3 Cup (5.33 tbs)
|Grated parmesan cheese
|1⁄4 Cup (4 tbs)
|Pignoli nuts/Walnuts
|1⁄4 Cup (4 tbs)
|Dried basil leaves
|2 Tablespoon
|2 Clove (10 gm)
|Beef flank steak
|2 Pound, pounded to 1/2-inch thickness
In blender or food processor, blend all ingredients except steak to a coarse paste; spread over top of steak.
Cut steak across grain into eight 1 -inch-wide strips.
Roll up each strip from short edge; secure with wooden toothpick.
Grill over medium heat for 7 to 8 minutes on each side or until done, brushing often with additional steak sauce.
Remove toothpicks; serve immediately.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 253 Calories from Fat 117
% Daily Value*
Total Fat 13 g20.4%
Saturated Fat 5 g24.9%
Trans Fat 0 g
Cholesterol 49.9 mg16.6%
Sodium 241.8 mg10.1%
Total Carbohydrates 7 g2.2%
Dietary Fiber 2 g8%
Sugars 2.4 g
Protein 27 g53.3%
Vitamin A 7.4% Vitamin C 4.6%
Calcium 15.6% Iron 19.5%
*Based on a 2000 Calorie diet


text:
Proudly Serving Missouri and Kansas with Quality, Dependable Foundation Repair Services
At KC Pro, we want you to know what sets us apart from other companies. To us, details matter – the precision of our work, the politeness of our people, the commitment to doing the job right. It begins with us coming to your home and giving you a detailed estimate and continues with our excellent customer services. We are your premium service provider of basement waterproofing, concrete repair and installation, mudjacking, and foundation repair in Kansas City.
We are a full foundation repair company, proudly installing ECP foundation repair, basement waterproofing and anchoring products. If you're having problems with the foundation of your home or building and you live in the Kansas City Metropolitan area, learn more about foundation repair Kansas City by reading how KC Pro solves all your foundation problems and makes your foundation solid as a rock.
If you have uneven concrete, including sidewalks, driveways, and patios, check out how KC Pro uses mudjacking to fix homes and building in the Kansas City Metropolitan area. Uneven concrete is not just an eye-sore – it's a safety hazard. Those that aren't used to stepping over it will likely trip. If you have elderly people or children around, it is important to fix the problem right away. We can repair old concrete or even lay new. We also offer mudjacking services for your sinking driveways or concrete slabs.
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Learn more about KC Pro, your leading provider of foundation repair in Kansas City. Or, if you need help right away, call us at (816) 245-5280 or give us more information on your needs and request a FREE Estimate.


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Providers (PA, NP, MD, DO) needed for San Francisco and elsewhere in California
Design your own schedule.
We provide expertise, marketing, equipment and 1/3 mil claims made liability coverage.
You provide your own transportation and smart phone.
Independent contractor status will allow numerous tax benefits.
Income is productivity based, a generous percentage
Candidates must have an unrestricted California license, be experienced in urgent care, and have good references.
This is a unique, interesting and extremely satisfying practice because of the variety and types of people we treat, and it is a great cure for office, clinic and ED provider burnout!
John Horning, MD
If interested, please fax your CV to:
Fax 415-666-2573


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Hand-Dyed Silk Bouquet Ribbon in Two Tone Pink Sweet Pea 1.25" x 72"
DetailsGet DIY wedding ribbon like this beautiful two tone pink sweet pea silk ribbon that is hand-dyed. This lovely bright pink silk bouquet ribbon with a subtle hint of light blue is perfect to wrap your bridal bouquets in romantic elegance!
- 1.25" x 72"
- Hand-dyed
- Handcrafted by Mary Jo Hiney Designs
Shipping & Returns
- Economy Shipping: 5-10 business days
- Ground Shipping: 1-5 business days
- Expedited, International, and SmartPost options available at checkout.
- More Shipping Information »
Return this item within 30 days for a full product refund. Return Policy »


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UCLA shows interest in Mora
LOS ANGELES – UCLA officials have had conversations with former Atlanta Falcons and Seattle Seahawks coach Jim Mora about the Bruins' coaching vacancy but are expected to interview other candidates before selecting Rick Neuheisel's replacement.
Mora, currently an analyst for NFL Network, expressed interest in the job last week and spoke with UCLA officials this week, it was reported. The two sides are expected to have further conversations, but UCLA will broaden a search that initially focused on two candidates, Boise State's Chris Petersen and Houston's Kevin Sumlin.
UCLA athletic director Dan Guerrero is scheduled to attend the IMG Intercollegiate Athletics Forum in New York City on Wednesday and Thursday.
Petersen last week turned down a five-year deal worth more than $3 million annually. Sumlin chose to pursue the Texas A&M post after meeting with Guerrero over the weekend. UCLA also contacted Miami coach Al Golden late last week. Golden has since informed UCLA officials he is not interested in the Bruins job.
Cincinnati coach Butch Jones, high on UCLA's original list, said on Tuesday he plans to stay at the Big East school.
Mora, 50, has no college coaching experience other than one season as a graduate assistant at Washington, his alma mater.
In his first season as an NFL head coach, Mora led Atlanta to the 2004 NFL South title with an 11-5 record and then the NFC title game where the Falcons lost to Philadelphia. The Falcons went 15-17 the next two seasons and Mora was fired after the 2006 campaign. Mora was heavily criticized by Falcons management, fans and media when he told a radio station late in the 2006 season he would take the Huskies head coaching position if offered. The position wasn't open at the time. Mora later said he was joking.
Mora spent two years as an assistant head coach and secondary coach on Mike Holmgren's staff before replacing Holmgren in 2009. He was fired after going 5-11 in his only season as the Seahawks' head coach.
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Kevin Constant has decided to close his Twitter account after being targeted by disgruntled Milan fans.
The former Chievo and Genoa man has been criticised by Diavolo supporters after some disappointing displays.
During the 1-1 draw against Genoa, tifosi unfurled a giant banner which read: 'Constant, instead of clowning around and being arrogant, respect those who watch your embarrassing performances."
The 26-year-old was also subsequently sent tweets which questioned his ability and whether he was worthy of the shirt.
Keep up to date with the latest news and action from Spain's Primera Division with Football Espana - from the team behind Football Italia.


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Davidia involucrata
Pocket-handkerchief tree, Dove Tree, Ghost tree
Taubenbaum - Arbre aux pochettes d'argent, Arbre aux Mouchoirs - Zakdoekenboom, Luierboom, Vaantjesboom
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Contacto directo
¿Empresa o particular?
Para poder proporcionarle la información adecuada, queremos saber si es usted:Propietario de un jardín particular Profesional de la jardinería
|10 - 15 m
|broad ovoid to rounded
|Corteza y ramas:
|light brown to grey-brown
|heart-shaped to ovoid, fresh dark green, 7 - 14 cm
|small, in purple-brown heads, cream-coloured bracts, May
|long-stemmed drupe
|parks and large gardens
|Tipo de suelo:
|any humid, nutritious soil
|Resistencia al viento:
|Western China
|Area de resistencia a las heladas:
Large tree that forms an undulating rounded crown later in life. In its natural habitat it grows to up to 20 m in height but in our climate its maximum is 15 m. The crown consists of sturdy branches that turn colour from olive green to yellow-brown. The trunk flakes off in various shades of grey. The leaves are heart-shaped to ovoid and tapered. It differs from the 'Vilmoriniana' variety in that the underside of the leaves is covered in grey hairs. The leaf edge is roughly serrated and the small flowers are in purple heads. The bracts make Davidia in full bloom an impressive sight. The creamy-white bracts hang down on either side of the flower heads. They are dissimilar in shape and size. The largest measure approx. 15 cm. The nut-like fruit hangs singly on long stems. Requires a sheltered site because of the risk of frost damage. You need a decade of patience before being able to enjoy the abundant flowers produced by Davidia involucrata.
¿Empresa o particular?
Para poder proporcionarle la información adecuada, queremos saber si es usted:Propietario de un jardín particular Profesional de la jardinería


text:
I always think that miniature fair organisers miss a trick by not selling miniature versions of their shopping bags. Come on people, everthing at a miniature fair should be miniature - the programs, the bags, the snacks. Well maybe not the snacks. Cake should always be full scale 😆
I found some canvas fabric that I bought from...I want to say Little Trimmings but it could well have been The Silk Route. Either way, the fabric is off white, heavy cotton and can be produced by soaking regular, heavy white cotton in a weak solution of tea or coffee.
The pattern is really simple. I've taken the measurements from a full size tote bag and reduced it to 12th scale.
I made the handles with 3mm webbed ribbon but you can use the same material as the bag and dip it in 'Fray Stay' to stop the edges from fraying.
The handles are glued on either side of the bag with fabric glue and left to dry. I'm making one long row of bags because it saves time.
I stitch along the top and over the handles to give them extra strength.
Then fold the fabric in half so the handles meet and the hem (wrong side) is showing, then stitch the sides.
If you want a bag with a flat bottom, sew the corners off like in the above picture.
This is the bags, inside out.
I've used the rubber stamps I made to decorate the bags. IKEA also do a pack of fabric pens which work really well.
So Kensington Dollhouse Festival and Miniatura, I expect you have some mini shopping bags to design 😄
Have a wonderful weekend
Pepper x


text:
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Amsterdam-based footwear label, Filling Pieces, presents a brand new, all-white version of its Mountain Cut Trainer. A successor of sorts to last year's "Black Friday" release, the new drop pairs a vulcanized rubber Margom cup sole with a white upper of soft bovine leather, and 100% authentic white python snake skin. Finished with tan leather lining and handmade in Portugal, the White Python Mountain Cut Sneaker is set to be available exclusively from END., Kith, and Filling Pieces' own Shoreditch store beginning this Saturday, April 12.