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ZoneAlarm Security Toolbar is very harmful infection toolbar that can enter into your PC without your permission while visiting malicious infective sites like porn video, infected low quality sites or with freeware or shareware programs. This toolbar program can enter into the PC if you open spam emails. ZoneAlarm Security Toolbar gets into your computer by bundling with other freeware program and can be the reason for severe issues with PC. This toolbar will not prove helpful for you anymore. It will display pop ups and fake messages and disturbs you.
ZoneAlarm Security Toolbar scans throughout the system and shows you fake messages. It distributes malicious codes into the system that will very much harmful and steals your personal and financial information and send it to cyber criminals for their illegal purposes. So it is very important to get rid of this infection as soon as possible with help of ZoneAlarm Security Toolbar removal tool. This infection can be removed very easily with this effective removal tool.
Severity of ZoneAlarm Security Toolbar infection
The severity level of ZoneAlarm Security Toolbar infection is very high and it can very easily show its behaviors as it makes its entry into the PC. In its initial stage, you can't know about this infection. After few days, you will know about this when it will start infecting important files. The important registry files are also on target and this ZoneAlarm Security Toolbar infection modifies them so the related software also becomes useless. The infection rate of ZoneAlarm Security Toolbar infection is very high. In very few time it can spread its files across most of the part of the system. Due to this infection several problems may arise and you will be victim of date lose. It can transfer very important and confidential files to third party that will prove very harmful for you.
Facts about Identity Theft
Identity theft is also one of the most dangerous features that can be proved very harmful for your system and important data. Having identity theft means, ZoneAlarm Security Toolbar infection is featured with the quality to stealing someone's identity without authorized permission. this features means to steal important data without your knowledge. This feature is mostly used by the hackers. They enter into your system and steal important and confidential information like financial data and other banking details.
Losing identity is very severe situation and this will put you into trouble. The reasons behind losing identity are opening infected emails, downloading infected freeware programs etc. Outdated or infected freeware program is the huge source of such kind of infections that will steal your identity without your consent. Infected emails attachments are also responsible for this kind of infections so users are suggested not to open spam or junk mails and also use firewall protection.
Webpage Redirection of ZoneAlarm Security Toolbar infection
Redirection is one of the key features of ZoneAlarm Security Toolbar infection that is designed to redirect your searches to malicious websites. It has the feature to hijack your browser or search engine. It is a very nasty infection and use to infect number of new machine every day. Once your pc has infected with this ZoneAlarm Security Toolbar infection then first you system settings will be changed then after you will see that your browser setting also has been changed. This is very uncommon situation for a computer user. After the infection, if you search for any key in Google or other search engines by your browser then you will be redirected to the other malicious websites from where severe infections can be downloaded and your system may be infected very badly.
The actual question is not how the ZoneAlarm Security Toolbar infection redirects the WebPages to the malicious sites but the question should be how a pc infected with ZoneAlarm Security Toolbar infection. It seems like when you visiting malicious sites or downloading infected programs to the system then there is a huge probability to get infected with ZoneAlarm Security Toolbar infection and it redirects you to the hub of infections so get ready to face the situation.
Reasons To Uninstall ZoneAlarm Security Toolbar Immediately
First let me tell you that ZoneAlarm Security Toolbar infection is very much severe and harmful for system. It can change the system settings, browser settings, registry files etc. It will not let your system work properly. Several important files, software, financial details and many other important things will be corrupt if your system has been infected with ZoneAlarm Security Toolbar infection. So if you want to save you PC and all these data then you need to uninstall ZoneAlarm Security Toolbar immediately. There are two way to remove this infection, first is manually and second is automatically. Let's discuss about manual method. It is very difficult and only for experienced and highly qualified people can dare to try this.
In manual method, you have to detect the infected files from throughout the system and then remove it. Also scan for the damage or infected registry files from the system folders. One thing should be noticed that a single mistake during deleting the registry files make your important software useless so beware before using manual method to remove ZoneAlarm Security Toolbar infection from system.
Pop Up and Fake Alert Messages of ZoneAlarm Security Toolbar
As your system is infected with ZoneAlarm Security Toolbar infection then you start getting several fake pop up messages. When this infection enters into the system, you will not come to know about it because it works in the background. Gradually, it spreads infection throughout the system and your several programs can be infected if it cannot be removed as soon as possible. Very soon this infection will caught all important programs throughout the system. After this, ZoneAlarm Security Toolbar infection starts throwing pop up and warning messages. These messages are completely fake and scary. One thing must be noticed that this messages only shows you number of infections, not the name of infections. If you get any kind of security warnings then it is completely invented and the intention behind these kind of security alerts to make you purchase full version of the spam program.
Some of the fake security alerts and warnings are –
Warning! Database update failed!
Database update failed!
Outdated redirect virus database are not effective and can't guarantee adequate protection and security for your PC!
Click here to get full version of the product and update the database!
ZoneAlarm Security Toolbar warning !
Application cannot be executed. The file cmd.exe is infected. Please activate your antiredirect redirect virus software
Warning ! Running Trial Version!
The security of your computer has been compromised!
Now running trial version of the software!
Click here to purchase the full version of the software and get full protection for your PC!
Expert Advice On Complete Removal Of ZoneAlarm Security Toolbar Infection
ZoneAlarm Security Toolbar infection has very high severity and it proves very harmful for your system and your confidential data. It will not only slow down PC but also very dangerous for your very important data. This infection can prove very harmful for confidential information like bank account details or other project details and send it to the remote hackers. As it enters into the system, it works in the background and gradually spread itself over your important locations and then throughout the system. This will be the most responsible reasons to slow down the PC. This infection can crash the system very easily if it is not be removed as soon as possible. This infection can easily steal your financial information and misuse it. So it is suggested not to visit malicious sites like porn sites and other infective sites which has several infections.
It is very important to remove this infection as soon as possible with one way out of two ways , manual method and automatic method. ZoneAlarm Security Toolbar removal can be very helpful to get rid of this infection easily and if you chose automatic removal tool. this tool will scan throughout the system and protect important data like registry files and software.
Automatic Removal For ZoneAlarm Security Toolbar Infection
As it is known that manual method to remove ZoneAlarm Security Toolbar infection is only for experts and it is time taking way to get rid of the infection. So it is suggested to opt automatic solution to get rid of infection completely from system. ZoneAlarm Security Toolbar removal tool is a automatic solution that will scan throughout the system to detect the infections and infected files. All the infected files will be removed as soon as it gets detected by this tool. This ZoneAlarm Security Toolbar removal tool also scans to detect the damage registry files and remove them to protect the further important files. This infection tool is supposed to remove outdated registry files and remove infected registry files. it will be the permanent solution to the infections and it also protects the PC from the other severe infections.


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Get in touch
Studio 21b
Victoria Works, Vittoria Street
Tel: 0121 236 9202
Professor Charlie Craddock gives his reaction to being awarded a CBE in the New Year Honours list.
"The dream can now become a reality."
Professor Charlie Craddock addresses London 2 Paris riders
QE nurses set to run for Cure Leukaemia!
What is leukaemia?
Jenny & Andrew Thompson
Brooke Cassidy
Fiona Codd
Chris Cottam's BIG JOGLE - April 2016
Glynn Purnell's Friday Night Kitchen 2015
London 2 Paris: Inspiring the Revolution
Great Birmingham Run 2015

subset: commoncrawl


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zelda battle quest
Nintendo Developer Roundtable: E3 2012
Each year at E3, Nintendo host a developer roundtable discussion after their main press conference. They use this as an opportunity to go into more detail about the things that...
A closer look at Zelda Battle Quest
"Graphically, this is really cool... I'm looking at an HD Nintendo game, and that's something that we really haven't been able to see before."
Representatives from popular...
More The Legend of Zelda: Battle Quest information and screenshots
Information on Nintendo's only Zelda-related offering at this year's E3 so far, Nintendo Land's The Legend of Zelda: Battle Quest is coming in fast. Nintendo has released the...
Very first look at NintendoLand's The Legend of Zelda: Battle Quest
The very first look at NintendoLand's The Legend of Zelda: Battle Quest can be seen after the jump. Keep in mind this is the very first footage and more details are soon to...


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Dan Simonson is a PhD Candidate at Georgetown University in the Department of Linguistics within the computational concentration. He's most interested in using linguistics and natual language processing to take objective and interesting slices of the real world to yield insight and understanding. In particular, this has led him to pursue problems related to narrative schemas, information extraction and retrieval, semantic modality, critical discourse analysis, and applying these topics to one another.
He recently (February 2015) passed his PhD Oral Exam. His orals committee consisted of Tony Davis, Amir Zeldes, and Nate Chambers.
Dan is most easily found in rooms with free coffee and on a bicycle. He tried both at the same time once in his youth and ended up burning his hand.
He also feels very weird writing about himself in the third person and will cease immediately.
Use my name at gmail.com. (I will respond to you from a different address that the first one forwards to. Let me know if you have some kind of filter that requires me to respond from the first one.)
Or, on Twitter, @thedansimonson.
Bash Your Way into Bash is a tutorial for using bash. It's for people who have no experience using command line interfaces.
ft is a library for dealing with lists of dictionaries in Python. It makes counting and finding things eas(y|ier). You can get ft off of pip (pip install ft). I've made an official page here with some code examples; the in-code documentation is pretty solid.
SPyTS is a tool for scraping tweets. For us plebs who don't have firehose access to Twitter, It spreads queries out over as evenly as possible of a period and prevents exceeding Twitter's API rate limits. SPyTS is available on github.
A lot of what we know is grounded in stories. Some stories tend to repeat themselves, and once they do enough, it's been hypothesized that we genericize the stories into something called a schema. I work to extract this type of world knowledge from language data and apply it to problems that would otherwise be inaccessible quantitative analysis.
My dissertation focuses on the extraction of these sorts of schemas, to understand their distribution and properties, and how to apply this knowledge to practical, real-world tasks.
You can find more information on this vein of research here.
Simonson, D. and Davis, A. (2016, November). NASTEA: Investigating Narrative Schemas through Annotated Entities. In the Second CnewS Workshop, EMNLP 2016, Austin, TX. [paper] [Workshop Slides] [DCNLP Slides]
Simonson, D. and Davis, A. (2015, July). Interactions between Narrative Schemas and Document Categories. In the First CnewS Workshop, ACL 2015, Beijing, China. [paper]
Throughout my time at Georgetown, I have been involved in a project building a theory and corpus of gradable modal expressions [NSF-funded, BCS-1053038]. Modal expressions are those that express possibilities. They span all parts of speech.
I played a number of roles on this project. During the experimental aspects of the project, where the annotation guidelines were developed and tested, I was responsible for reporting interannotator agreement scores. During the corpus construction component, I built and maintained a cross-platform tool for adjudicating annotator output. Throughout both stages of the project, I managed data as it flowed between phases of the project.
Rubinstein, A., Harner, H., Krawczyk, E., Simonson, D., Katz, G., and Portner, P. (2013). Toward Fine-grained Annotation of Modality in Text. In Proceedings of the Tenth International Conference for Computational Semantics (IWCS 2013). [Paper]
Simonson, D., Rubenstein, A., Chung, J., Harner, H., Katz, E.G., Portner, P. (2012, February). Categorizing Modals with Amazon Mechanical Turk. In the Proceedings of the Mid-Atlantic Colloquium of Studies in Meaning (MACSIM 2012). [Poster]
Zeldes, A. and Simonson, D. (2016, August) Different Flavors of GUM: Evaluating Genre and Sentence Type Effects on Multilayer Corpus Annotation Quality. In the Proceedings of LAW X: 10th Linguistic Annotation Workshop, Berlin. [paper]
Sierra, S., Simonson, D. (2014, October). Gender and cool solidarity in Mexican Spanish slang phrases In the Proceedings of New Ways of Analyzing Variation 43. Chicago, IL. [Slides from NWAV Presentation]
During my undergrad, I was a physics major and participated in astronomy research under the guidance of Harold Butner. I presented posters in two annual meetings of the American Astronomical Society as results of this research. These proceedings derived from two separate projects involving the DEBRIS target set, a search for binary stars using the Herschel Space Observatory. The first was a search for estimates of stellar age in the literature of our project's target stars; the second reported preliminary results of an observing run in the infrared identifying candidate binaries.
Simonson, D. E., Butner, H. M., Trelawny, D. T., Evans, C. M., Duchene, G., Rodriguez, D. R., ... and DEBRIS, T. (2010, January). Searching for Previously Unresolved Binaries in DEBRIS Survey Target Stars. In Bulletin of the American Astronomical Society (Vol. 42, p. 400). [Poster]
Butner, H. M., McCauley, P., Simonson, D., Matthews, B., Greaves, J. S., Duchene, G., ... and Zuckerman, B. (2009, January). Stellar Ages Of The Debris Sample Stars. In Bulletin of the American Astronomical Society (Vol. 41, p. 209). [Poster]
Pluto never should have been planet.
My first website was D's C&c Page. I lost the whole thing when, for some reason, Geocities decided I violated their TOS. No explanation was given.


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Dar Tamo Hotel Fes
89 Derb Mzerdeb Gzira, Fès, Morocco
Located close to the mosque and the palace, Dar Tamo Hotel offers a sundeck and a spa center.
This hotel is about 2.4 km away from Royal Palace Fes and Fes el-Bali. The property is about 10 minutes' walk of Glaoui Palace, Medina and Karaouiyne.
All spacious guest rooms including Spacious Triple Room, Triple Room and Double Room come with modern facilities. Guests can make use of en suite bathrooms with a bathtub, a shower and complimentary toiletries.
Dishes of Moroccan cuisine are served in the lounge restaurant.
The venue is notable for the quiet location within a 20-minute drive to Sais airport.
The property offers a baggage storage, parking and a tour desk along with a photocopier and a copier.
On-site facilities for children include meals and cots.
Important information
- Children and extra beds
- There are no extra beds provided in a room.
- Parking
- Free Wi-Fi
- 24-Hour Check-In
- 24-Hour Front Desk
- Non-Smoking Rooms
- Terrace
- Luggage Storage
- Credit Card Accepted
- No Pets Allowed
- Restaurant
- Bar
- Children's menu
Leisure & Sports
- Sun terrace
- Paid Shuttle Service
- Breakfast in the Room
- Special Diet Menus
- Tours/ticket assistance
- Internet Services
- Fax/Photocopying
- Newspaper service
- Currency Exchange
- Car Rental
- Self-service laundry
Room Amenities
- In room air conditioning
- Free Wi-Fi in Rooms
- Patio
- Dressing area
- Private Bathroom
- Hair dryer on request
- Room toiletries
- AM/FM Alarm Clock
- Cribs Available
89 Derb Mzerdeb Gzira, Fès, Morocco
All spacious guest rooms including Spacious Triple Room, Triple Room and Double Room come with modern facilities. Guests can make use of en suite bathrooms with a bathtub, a shower and complimentary toiletries.
Please, select dates to see available rooms.
Availability and rates
Checking available rooms
Searching rooms…
Add review
Your details
If you have any questions regarding your reservation made through our website, please go to our Contact Us page.
Contact Us
Dar Tamo
89 Derb Mzerdeb Gzira, Fès, Morocco
What's nearby
- Local Attractions
- Andalusian Mosque350 m
- Nejjarine Museum of Wood Arts and Crafts650 m
- Medina of Fez900 m
- Bou Inania Medersa1.1km
- Journey Beyond Travel - Private Day Tours1.2km
- Jardin Jnan Sbil1.8km
- Kairaouine Mosque (Mosque of al-Qarawiyyin)1.8km
- Fez el Bali4.1km
- Souk400 m
- complexe El batha"EL Morkkab"1.2km
- City Center4.2km
- Airports
- Sais15.1km
- Train stations
- Ville Nouvelle - Fes Railway Station3.7km


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Purchasing Conditions
Our current general purchasing conditions can be downloaded HERE in the PDF format.
Supply conditions
General Supply Conditions: we enter into our supply contracts based on and incorporating the ORGALIME-Conditions. These Conditions may be instantly downloaded HERE in PDF-format using the access data notified in your contractual documentation. Upon request we shall be pleased to send these Conditions to you in PDF-format by email as well. Kindly contact any of your contact persons within our company in this regard.


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Fillmore Glen State Park is an oasis of cool, dense woods crowding into a long, narrow gorge. Its hiking trails offer spectacular views, unique geological formations, including five waterfalls, and a botanically rich glen. The park has 60 campsites, a stream-fed swimming pool and fishing in the Owasco Lake inlet. In the winter, hiking, cross-country skiing and snowmobiling are permitted on unplowed roads. For those who prefer the luxuries of home, the park offers a full service cottage located on the shore of Cayuga Lake at Long Point. Cottage amenities include a kitchen with a gas stove, refrigerator, sink, full bath, hot water; electricity, bedroom with double bed and dressers, main room with a sleeper sofa, furniture, dining table with chairs, a wood stove, boat dock, picnic table, fire ring and grill and a small lawn area.
Great 1.5 hour hike on beautiful fall day.
Hiked up the gorge trail and came down the south rim trail.
The gorge trail was beautiful, even though there wasn't much water flowing. It was worth the drive and worth the effort. There was plenty of parking, nice bathrooms and a nice picnic area.
Beautiful trail, we started on the "gorge trail" which has 8 bridges that cross the dry creek. We did some creek walk but that was to get better pictures. Then we planned to go to the dam, but we never made it unless we just did not find it. We did not take the "north rim trail" back due to us looking for the dam and us ended up on the snowmobile trail to lope back. In total, it was a 5 miles loop around.
Just went yesterday. Hiked the Gorge trail and took the South Rim trail back. Wish there had been more water. Definite re-do in the spring or winter if it's open. The South Rim was boring. Nothing to see and not "foot friendly" definitely tighten boots before going down. $7.00 entrance fee.
Love this spot!!!
One of my family's favorite hiking trails! We have been going for the past 4 years. My youngest was 4 when she started. Easy beautiful hike!
Great hike. We took the gorge trail. Very scenic. Easy walk. Trail used to lead to dam and pond but no longer does. Beautiful walking path with several bridges. This is a state park so there is an entrance fee.
We camped as well as hiked the north rim trail, south rim trail and part of the gorge trail. Beautiful trails nicely shaded but starting at north rim is pretty steep.
I had the best day hiking here. I love the slate rock formation.


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I have one in L2, 4 1/4 If interested I have one in L2, 9 of 10 condition. Not interested in trades but if you want to buy email me through profile or leave yours and I'll send you pics and info. Thanks.
have 2 boris becker 11 midplus rackets in # 3 grips. 325g model. email firstname.lastname@example.com for prices and pics.
Huppe, i could not find your email address so you can contact me at email@example.com thank you


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Welcome to Shinpai Deshou!
ようこそ!Feel free to search topics or browse by categories below. Our various resource links will be updated with each blog post. Please check back frequently for new, helpful sites! Contact us with questions or suggestions at email@example.com Categories
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Category Archives: JLPT
JLPT Registration Open for Dec. 2014 Test
Registration for the Dec. 2014 test is now open to test-takers in Japan and overseas. For those taking the test in Japan, register online with JEES: http://info.jees-jlpt.jp/application/ For overseas applicants (anywhere outside Japan), click here to find your country's registration site: … Continue reading
Posted in announcements, JLPT
Tagged Japanese Language Proficiency Test, JLPT, JLPT Dec. 2014
Leave a comment
Japanese Studies: 5-10-20 – A Year Out and a Long Way to Go
For the third article in our Japanese Studies: 5-10-20 series, today we will hear from Kathy Rice, a recent college graduate and current JET Coordinator for International Relations, who will talk about how she cultivated skills and resources throughout her college years and … Continue reading
Posted in JET, JLPT, jobs, language schools, living abroad, main posts, senior year, social networking, study abroad, summer program, undergraduate
Tagged CIR, Coordinator for International Relations, internship, Japanese, Japanese language, Japanese Studies: 5-10-20, JET, JET Program, JET programme, study abroad, undergraduate
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Job Opening: Assistant Director of Admissions/International, Monroe College
Institution: Monroe College Location: New Rochelle, NY Posted: 08/23/2012 Application Due: Open Until Filled Education: BA required, MA preferred SUMMARY Monroe College seeks outcomes-focused Assistant Directors to plan, coordinate, and supervise international enrollment initiatives directed at audiences in Asia, Latin … Continue reading
Posted in announcements, JET, JLPT, job openings, jobs
Tagged admissions, higher education, International Admissions, job opening, Monroe College, New Rochelle, New York
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Mr. Collier's accomplishments include: | |
• |
Founder and President of the Shark Research Committee |
• |
Pioneering the technique for using "interspace measurements" from tooth impressions to determine shark species and size. |
• |
The first researcher to cite the significance of White Shark attack "recurring locations," as they pertain to attacks on humans. |
• |
The first researcher to note the significance, and correlation, between juvenile White Shark appearances at Southern California beaches and Grunion spawns. |
• |
The first to postulate the significance behind the oddity of "eye rolling" by the White Shark during feeding and/or investigation behaviors. |
Mr. Collier has appeared in more than a dozen Discovery Channel Shark Week Specials and more than two dozen independent documentaries. He has been a continuing consultant for TV news programs including; NBC Sunday Today Show, KNBC News, CBS News, The O'Reilly Factor, ABC News, CNN, The Heartland on FOX News, FOX News Los Angeles, KFMB, MSNBC, and most recently FOX News Geraldo At Large.
For additional information or to arrange for an appearance please
contact Ralph S. Collier at email@example.com


text:
Tuesday, Feb. 8, 2005: Ultraviolet Product Is Designed to Kill 99 Percent of Pathogens
February 8, 2005
ORLANDO, Fla. - The BreatheCLEAN® Whole Home Air Purification System, from BreatheCLEAN Air Purifiers, is a new ultraviolet product that harnesses enough high-intensity ultraviolet light to consistently destroy mold spores, bacteria, fungi, yeast, dust mites, viruses, such as cold germs and influenza, and other airborne mircroorganisms, according to the company.
The unit is installed into the home's central ductwork. It plugs into a standard electrical outlet, drawing less energy than a 75-watt light bulb, yet provides 24,000 microwatts of ultraviolet energy, enough to kill 99.9 percent of pathogens based on published ultraviolet susceptibility data, says the company.
The product is designed to be installed simply and cost effectively, the company says, with typical installations by HVAC professionals taking less than 30 minutes.
Did you enjoy this article? Click here to subscribe to The NEWS Magazine


text:
Make A Favicon Free
Make A Favicon Free
Welcome to Traffic Showdown Stage Setters!
This is very cool and free for all my wonderful members and visitors to our daily news blog!
You can now make a favicon Free!
What Exactly Is A Favicon?
A favicon is that stylish little icon that is displayed in your browser next to the website address. You can see ours is a little Showgirl up in your browser bar!
If you're wondering where the name came from then its short for "Favorites Icon".
Its called that because if your visitors add your site to their favorites then it will also shows up on their list making your site stand out that little bit more.
Why would I want a Favicon?
Most professional websites usually have them so having one will not only put your site alongside the pros but also help distinguish you from the rest.
How do I get a Favicon?
If you want one then it's extremely easy with our favicon generator. All you need is an image (any size will do), submit it using the favicon generator plugin, and after a couple of seconds you'll get your image back compressed and resized for use as a favicon.
It really is that simple!
Which browsers are favicons compatible with?
Most versions of the major browsers support favicons. Some examples include Internet Explorer 5/6/7/8+, Firefox 1/2/3+, Mozilla 1/2+, Netscape 7+, Opera 7+, Avant 1.1, Konqueror 3+, Safari and many more.
Ready to make your Favicon?
It doesnt get much easier than this…. have a go by clicking this link and see what you can do!
(I needed to put it on a different page because the coding would not fit the blog theme!)
Please share this page – your friends will love you for it!
Enjoy your day! :)
{ 3 comments… read them below or add one }
- March 15, 2011 at 12:59 pm
Yihee I'm here checking out Favicons ^_^
Thanks for this Kym!Rain
- September 18, 2014 at 1:39 am
Your link to make a Favicon Image is not working .. I tried it several different times .. thank you .. Marion
Leave a Comment


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Hegel: Elements of the Philosophy of Right Paperback
by Georg Wilhelm Fredrich Hegel
Edited by Allen W. Wood
Part of the Cambridge Texts in the History of Political Thought series
This book is a translation of a classic work of modern social and political thought, Elements of the Philosophy of Right.
Hegel's last major published work, is an attempt to systematize ethical theory, natural right, the philosophy of law, political theory and the sociology of the modern state into the framework of Hegel's philosophy of history.
Hegel's work has been interpreted in radically different ways, influencing many political movements from far right to far left, and is widely perceived as central to the communication tradition in modern ethical, social and political thought.
This edition includes extensive editorial material informing the reader of the historical background of Hegel's text, and explaining his allusions to Roman law and other sources, making use of lecture materials which have only recently become available.
The new translation is literal, readable and consistent, and will be informative and scholarly enough to serve the needs of students and specialists alike.
- Format: Paperback
- Pages: 569 pages, index, bibliography
- Publisher: Cambridge University Press
- Publication Date: 25/10/1991
- Category: History of ideas


text:
David French, Senior Vice President of the National Retail Federation, the major industry group lobbying for the so-called "Marketplace Fairness Act," (more aptly named the "National Internet Tax Mandate") recently commented that "….the law [governing Internet sales] today is a 20th-century interpretation of an 18th-century document…." Mr. French's comments are typical of those wishing to expand government power beyond the limits established by the United States Constitution.
Those of us who insist the federal government remain within the confines prescribed by the Constitution are used to condescending lectures about how the Constitution is a "living document" whose principles evolve over time. I was even once informed by the then-Chairman of the House Committee on Foreign Affairs, who was widely considered one of Congress' leading constitutional authorities, that the constitutional requirement for a declaration of war was an anachronism!
While Mr. French may not go that far, he is arguing that Congress turn the Commerce Clause on its head by passing the Internet Tax Mandate. The Commerce Clause was intended to facilitate free trade by giving the federal government limited power to ensure state governments did not impose taxes and regulations on out-of-state business. Contrary to modern belief, the Commerce Clause was not intended to give Congress power to regulate every sector of the economy. And the Commerce Clause was certainly not intended to allow Congress to help state governments collect taxes on purchases from out-of-state merchants.
The National Internet Tax Mandate overturns the Supreme Court's 1992 Quill v. North Dakota decision that states can only force businesses to collect sales tax if the business has a "physical presence" in the state. Quill represented a rare instance where the Supreme Court properly interpreted the Commerce Clause. Thanks to the Quill decision, the Internet has remained a tax-free zone, though some states require consumers to later pay taxes on products they purchased online. This freedom has helped turn the Internet into a thriving and dynamic sector of the economy, to the benefit of entrepreneurs and consumers.
Now that status is threatened by an alliance of big business and tax-hungry state governments seeking new powers to force out-of-state business to collect state sales taxes. Far from updating the Constitution to fit the needs of the 21 st century, the National Internet Tax Mandate is a throwback to 18 th century mercantilism.
The National Internet Tax Mandate will raise the costs of doing business over the Internet. Large, established Internet companies, such as Amazon, can absorb these costs, whereas their smaller competitors cannot. More importantly, the Mandate's increased costs and regulations could prevent the creation and growth of the next Amazon.
Raising prices on goods purchased over the Internet will also impose an additional hardship on American consumers, many of whom are already struggling because of the troubled economy. And giving ravenous state governments new authority to tax sales made by out-of-state businesses practically guarantees future sales tax hikes, as the arguments will be made that most of the increases will fall on out-of-state businesses. These businesses will lack effective ability to oppose the tax increases — a form of taxation without representation.
Contrary to Mr. French, it is the proponents of the National Internet Tax Mandate who are embracing outdated principles, such as higher taxes on prosperity, piling more regulations on already over-burdened workers, and legislation designed to help entrenched businesses at the expense of their smaller competitors and consumers. Opponents of the Internet Tax Mandate recognize that the principles of limited government and free markets represented by a true reading of the Commerce Clause provide a timeless guide to economic growth and prosperity.
Read the original article on Campaign For Liberty. Copyright 2013.


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From Awfulpedia, a free encyclopedia that anyone can edit
(Redirected from babby)
A baby is a newborn human child. Babies often grow up. Once the growing process is complete, they are known as adults.
FYAD: Bi Till I Die, Poopy Palpy, Skip Rogers, Rocky Harmgood, rubber cat, Bier Beware, liquidator vrunt, Milos Missile Silos, Fab Boner, Cowcaster, fax machine demon, uberkeyzer, How much food, asdindebimte, maxnmona, clickblipclick, Man of Steel Wool, Casey Chaos, N...ev/er, JOHNSON MCHUGH, GigaBi, dillinger!, +2 Sword of Chutney, Pogue, Just Add Corn, Ramses Dude, forgetful susan, bugs in your car, Nutmeg, Mirabel, Antonin Artard, Hal Stonecastle, casual colors, nenelightangel89, Haoma, Rascal, ATMS 101, hotornotAvenger, Elky, Nigg0r Bone, Red Skin, A Good Day To Bi, German Joey, sprankton A noun, crabrock, boo fyadley, tres dessert, Vince Wolfjaw, Hercules Vandermollen, Livecock, Sewer Adventure, Ms Lonelyhearts, EVIR Gibson, Hoague Oxchest, Turd Princess, The Red Baron, Jawlinez, graey alien, Deg, locdogg, anime-fat, Pretzelcoatl, dumb silly baby, BrunchTime833, arc_arsenal, Lance Staminero, Smoking_Dragon, teekun, Prodigal Sun, Rooder, Coolidge, WORLDS BEST BABY, Samadhi, Father Wendigo, sq, Gesus, Slobs The Burpy, That Turkey Story, idiotsavant, the bi bandit, gobbles, squid41, nic olas, Creeper, TOO, Fart Amplifier, Sarumpaet, Talking Fart Cloud, Pigthe, Days Go Bi, Ah Pook, menth0l, DaTroof, Toe Rag, cheese and crackers, deez nutz, Mozi, Good Times Orc, AUNT FROM HELL, LSTB, okiedokie, and Wykyd Sceptre.
jason has a fat head lbhs class of '12!!!!!!!!!
Please consider updating your plan to include Trickle Down Antibiotics, the Millennial Meltdown, and other new options.
The most beautiful woman on all of Facebook is no longer just enchanting your Facebook feed. She's here, y'all!
I mean, they're not that bad. "Substandard" vending machines.
Which Overwatch Characters Would Bone Each Other? Not In Our Imaginations, But, Like, In Real Life?
The Something Awful front page news tackles anything both off and on the Internet. Mostly "on" though, as we're all incredible nerds.
Copyright ©2017 Rich "Lowtax" Kyanka & Something Awful LLC.


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NewswireToday - /newswire/ - London, Ontario, Canada, 2011/09/16 - Hearing voices? London-based business Voices.com will be the official social media sponsor for the SENSEsation2011 UnGala presented by CNIB and EZ Rock 97.5 - CNIB.ca / Voices.com.
Voices.com is honoured to help pave the way for the SENSEsation2011 UnGala, a fund-raising event unlike any other. It will ignite the senses and bring out the funky and fabulous in everyone. The event will take place on September 30, 2011. Letting people know about the ungala is just one aspect of this multi-faceted sponsorship that will shine some well deserved light on CNIB and the life-changing programs and services they provide to over 3,000 people in London and surrounding area. Voices.coms strategy for promoting the ungala includes creating new web content specific to the event, raising awareness about CNIB and drumming up support online. A perfect fit with CNIB, Voices.com recognizes the significant role that voiceover plays in enriching the lives of the people who are blind or partially sighted through audiobook consumption, text-to-speech, audio description and other services. Voices.com Chief Marketing Officer, Stephanie Ciccarelli, was quick to see how the company could be of service to CNIB and designed a social media campaign tailored to the event complete with the added goal of highlighting measures people can take to help protect their eyes and prevent vision loss. Ciccarelli shares,We are excited to be part of this event and are grateful to CNIB for the opportunity to contribute. Our goal is to creatively show Londoners and the world how vision loss and voiceover have impacted our community and how sight and sound affect all of us. Lindsay Neale, CNIB Specialist, Corporate & Community Development, says,CNIB is so grateful to have the support of voices.com to promote this important event and our organization via their extensive social media platforms. This partnership is not only a great fit for the unique UnGala; it also lays the foundation for a rewarding relationship between our organizations. Thank you for helping our voice to be heard in spreading the message of vision health and vision hope! Fans of Voices.com have been seeing relevant updates via Facebook, Twitter and LinkedIn in support of the SENSEsation2011 UnGala since Monday August 15th. SENSEsation 2011 UnGala will take place on September 30th, 2011. About Voices.com Voices.com is the industry leading website that connects businesses with professional voice talents. Radio and television stations, advertising agencies and Fortune 500 companies rely upon the Voices.com marketplace to search for, audition and hire voice talents with the assistance of our innovative SurePay escrow service and our award-winning Web application. Voices.com has a global network of over 30,000 voice actors in over 100 languages and currently serves more than 107,220 users online. Over 69,662 MP3 voice-over demos are listened to by 1,159, 901 unique visitors, creating 6911 job opportunities on average, each and every month. About CNIB CNIB (CNIB.ca) passionately provides community-based support, knowledge and a national voice to ensure Canadians who are blind or partially sighted have the confidence, skills and opportunities to fully participate in life. To learn more, visit cnib.ca or call the toll-free CNIB Helpline at 1-800-563-2642.
Written by / Agency / Source: Voices.com
Availability: All Regions (Including Int'l)
Traffic Booster: [/] Quick Newswire Today Visibility Checker
Distribution / Indexing: [+]


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Apple Training Series: iWork '09
Guide price: £29
Last updated on 21st May 2012
Tags: pearsonhardware software
Apple Training Series: iWork '09
The official curriculum of the Apple iWork '09 certification course, this self-paced book/DVD combo uses practical, step-by-step lessons to get you up and running with Keynote, Numbers and Pages in no time. Step-by-step instructions for quick learning Photo and video examples of actual projects DVD with easy-to-follow tasks Complete details about all new iWork '09 functions
Login or Register to add this to your wish list or favourites.
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Excel Training
That is why the number of people suing MS excel training is increasing every day. MS excel skill increases your demand in the industry.
Producer Company Software
India's premiere software development company in India, Webinfotech Solutions our phone no: 09330160431, mail id- email@example.com) has recently created extremely useful and cost-effective Producer Company Software. One of the best software development companies in India i.e Webinfotech Solutions has recently developed software which is aimed at helping out the producer companies. The software is extremely useful and user-friendly and is beneficial for any company which is doing production business. The software is fully customised providing the business with each and every tool it wants for its smooth functioning. To learn more about the best producer software company in India please contact at: Webinfotech Solutions 2C, Kalicharan Ghosh Road, 1st Floor, Kolkata-700050 Mob : +91-9330160431 Phone No: 033-65056655 / 56 E-Mail:email@example.com Website:http://www.webinfotechin.com
sales training courses singapore
We have many sales training courses like achieving sales success, continuous excellence in sales and increase sales by understanding buyer psychology etc.Further more info call +65 98417018 or just visit http://goo.gl/m3l9uT
Custom Software Development Company
JanBask tends to work closely and proficiently with their clients to develop custom application to increase their strategic benefits, flexibility and performance. Through our custom application development services, we bring you the right solution and technology that your business requires sufficiently. Our highly experienced developers have deep knowledge and expertise to pull off any task as per our clients needs and preferences


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msvcp120d.dll is missing, i have downloaded it but still missing how to fix it? :O
If i playing somethimes he crash and close AVA.
Can u fix it?
msvcp120d.dll is missing, i have downloaded it but still missing how to fix it? :O
Riddick (05-09-2014)
does it still work after the update??
not workinf R3DDOT
kicking from the serverafter update
Works fine for me i just have to use a different injector. And the change nickname option only changes the name In-Game if you talk in lobby chat or if you are in a lobby waiting for a match to start other people can still see your realname. Is it supposed to be like that?
When ROF is ON in cant set C4 u can fix this
It still works. I'm using it right now. Works completely fine.
@R3DDOT u can ADD skype round or super jump?
[SIZE=2][COLOR=#FF0000][FONT=Arial Black][B]If the facts don't fit the theory, change the facts.
Learn from yesterday, live for today, hope for tomorrow. The important thing is not to stop questioning.
Try not to become a man of success, but rather try to become a man of value.
You have to learn the rules of the game. And then you have to play better than anyone else.
-Albert Einstein
Skype round hahah
It is Skip Round, please!


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Center Your Heart through spititual books
"Richard Bandler is a genius"
As a practitioner of NLP, I search for everything I can find to better my skills. This book simply explains a most powerful view that there is a program to our thoughts, emotions and actions that CAN be altered for the best, in short order. Years of counciling is not needed in many cases.
it was well-versed and had many ideas that everyday people can use in their lives. the author writes in such a way that you feel as if he is talking to you simply and directly. He put in interesting comical moments. I will listen to it probably at least 10 times and Implement these ideas.
"Life Changing"
I am a speaker who works with sales professionals, business owners and managers. The principles in this amazing book will help me understand better the dynamics of people by understanding myself better, therefore improving my ability to relay my messages.
Shift Your Brilliance
Leaders Eat Last
Think and Grow Rich
A very good pace in relaying the messages outlined in the book.
Change makes you want to hustle!
"Making lasting change."
Great book on making lasting changes in your life. Great exercises that really can help.
Candace Young
"Great book! highly recommended"
Great Audio book, the narrator was good too. Great NLP exercises to improve in any aspect of tour life.
I am 26 year old factory worker with a lot of time on my hands, looking to improve myself.
"book of the master in NLP"
you can compare just with the same author.
worth while, serious book,takes time to practice.good luck
RPG, history and movie fan
"PDF files should be provided of key lists"
I would recommend the book to a friend, but probably not this audiobook. Lists that are essential for key steps are not provided, diluting the helpfulness.
There isn't really a scene in the book. But there are helpful steps to deal with phobias and mindsets.
I will try to return this book, as the audiobook does not provide all the content from the printed book, and this is a major disadvantage and dis-service to the listeners.
"It will change your life. Period."
If you want to take life by the lapels and take absolute control of your future then study the heck out this book and more importantly, do the exercises.
Getting over fears and phobias as well as creating unstoppable resolve for taking on new productive habits.
No, but he does an OK job as narrator.


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XAs hot as Spanish men are, we figured the only thing that could possible be more �caliente� than that would we a 21 year old version and did Marcos ever prove us right! A combination of that jet black hair, deep dark eyes and devilish little grin just exuded pure sex.Despite his young age, we weren't surprised to learn he's been jacking and boinking for ten years already. Take the tight, lean little body, sexy pouting lip and add on a thick, uncut 7.5� cock on his 5'7� frame and his cock has pointed the way right into my many a hole - and thankfully, right in front of our cameras!Not content to just sit and stroke, he worked that big cock while he rolled around the floor, showed off the creamy tight ass before flipping back over to deliver a big white gusher large enough to swim in!
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Tramon Williams addressed the way his shoulder injury has changed the way he plays the game. That and more in today's Daily Links...
The Packers are favored by 5 1/2 points and the over/under is 53. So what's going to happen? Brian Carriveau has the prediction.
Donald Driver was back in action for the Packers padded practice this afternoon.
From the players to the front office, talk of an undefeated season has begun in Green Bay.
Aaron Rodgers deflected attention from Brett Favre's recent comments about the current quarterback. That and more in today's Daily Links...
Wide receiver James Jones hosts 1 on 1 With the Boys on 101.1 WIXX in Green Bay on Thursday afternoons.
Frank Zombo and Ryan Grant were back on the practice field this afternoon, while Bryan Bulaga continued to sit.
Coming off his 408-yard passing performance against the Denver Broncos, quarterback Aaron Rodgers received the honor handed down by the NFL on Wednesday.
Rob Demovsky of the Green Bay Press Gazette also joins Corey and Aaron for tonight's live edition of Transplants.
Quarterback Aaron Rodgers is so good because he plays well when the Packers need it most, in the red zone and on third downs
Suspended defensive lineman Johnny Jolly awaits a hearing next Tuesday in Houston. That and more in today's Daily Links.
The Packers running back will practice for the first time in more than a week after suffering a bruised kidney in Week 3.
Brett Favre joined 790 The Zone in Atlanta with Mike and Hans. Here's what he had to say.
Head coach Mike McCarthy said wide receiver Donald Driver is not expected to miss the next game. That and more in today's Daily Links...
The Mike McCarthy Show airs on WFRV channel 5 locally in Green Bay at 6:30 p.m. Central time.
Ryan Grant will return to practice on Wednesday. Grant and Donald Driver should play Sunday against the Falcons.
Packers tight end Tom Crabtree joins us for an interview to talk about the seemingly unstoppable Packers offense following Sunday's win over the Broncos.
Suspended Packers defensive lineman Johnny Jolly was arrested this past Saturday on a drug possession charge in his native Houston.
Bart Winkler of K107 in Fond du Lac and Brian Carriveau look back at a Packers' 49-23 victory over the Denver Broncos on Sunday at Lambeau Field.
The pair from the NFC North have proven themselves as two of the top teams in the NFL, and they're on a collision course towards Thanksgiving Day in Detroit.
Head coach Mike McCarthy will address the wide receiver's injury during his afternoon press conference.
ESPN's John Clayton reports that Jordy Nelson has signed a three-year contract extension.
Aaron looks at how things should play out when each team has the ball and gives his prediction for the game.
All the news, notes and other relevant info Packers fans need for todays match-up with the Denver Broncos
Former Packers tight end coach Bo Pelini is now the head coach at Nebraska who plays their first Big Ten Conference game tonight at Wisconsin.
The linebacker for the Green Bay Packers is the honorary chairman for the event being held at the Summerfest grounds in Milwaukee.
Wide receiver Jordy Nelson encouages fans to donate old cellular phones, the proceeds from which will be used to benefit domestic violence agencies and shelters.
Agent Alan Herman said Nick Collins surgery went well and his progress will be re-evaluated in six months.
Former Packers safety Mark Murphy is an assistant coach at St. Vincent-St. Mary in Akron, Ohio where they're off to a 5-0 start.
Aaron's picks for Week Four of the 2011 NFL Season.


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We have a total of three of these with original corks. Corks are crumbling from age.
We were told these would turn purple in color if exposed to sunlight. These have been in the dark for years and we have not tested to see if the flasks would change color. Most collectors want the original color of glass.


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'Beauty and the Beast' debut weekend earnings revised up
NEW YORK (AP) — Disney's live-action "Beauty and the Beast" was an even bigger hit than first thought.
The film's weekend box office earnings were revised up nearly $5 million from estimates Sunday. In final figures Monday, Disney said "Beauty and the Beast" made $174.8 million in North American theaters.
The result set numerous records. The film, directed by Bill Condon and starring Emma Watson and Dan Stevens, is not only easily the biggest hit of 2017 so far, it's the biggest opening for a PG-rated movie, the top debut ever in March and ranks among the top-10 openings ever, not adjusting for inflation.
Analysts expect the film to make $1 billion globally.
The top 20 movies at U.S. and Canadian theaters Friday through Sunday, followed by distribution studio, gross, number of theater locations, average receipts per location, total gross and number of weeks in release, as compiled Monday by comScore:
1. "Beauty and the Beast," Disney, $174,750,616, 4,210 locations, $41,508 average, $174,750,616, 1 week.
2. "Kong: Skull Island," Warner Bros., $27,832,142, 3,846 locations, $7,237 average, $109,107,436, 2 weeks.
3. "Logan," 20th Century Fox, $17,815,677, 3,687 locations, $4,832 average, $184,342,562, 3 weeks.
4. "Get Out," Universal, $13,437,220, 2,979 locations, $4,511 average, $133,305,365, 4 weeks.
5. "The Shack," Lionsgate, $6,005,739, 2,825 locations, $2,126 average, $42,490,369, 3 weeks.
6. "The Lego Batman Movie," Warner Bros., $4,602,235, 2,735 locations, $1,683 average, $167,325,587, 6 weeks.
7. "The Belko Experiment," OTL Releasing, $4,137,230, 1,341 locations, $3,085 average, $4,137,230, 1 week.
8. "Hidden Figures," 20th Century Fox, $1,475,280, 1,162 locations, $1,270 average, $165,534,349, 13 weeks.
9. "John Wick: Chapter Two," Lionsgate, $1,183,506, 1,065 locations, $1,111 average, $89,774,310, 6 weeks.
10. "Before I Fall," Open Road, $985,631, 1,551 locations, $635 average, $11,246,308, 3 weeks.
11. "Lion," The Weinstein Company, $734,336, 621 locations, $1,183 average, $50,000,950, 17 weeks.
12. "La La Land," Lionsgate, $531,568, 585 locations, $909 average, $149,765,752, 15 weeks.
13. "Split," Universal, $505,540, 604 locations, $837 average, $136,864,765, 9 weeks.
14. "Rogue One: A Star Wars Story," Disney, $502,905, 179 locations, $2,810 average, $530,748,437, 14 weeks.
15. "The Sense Of An Ending," CBS Films, $480,406, 281 locations, $1,710 average, $533,003, 2 weeks.
16. "A Dog's Purpose," Universal, $477,890, 594 locations, $805 average, $62,932,920, 8 weeks.
17. "Fist Fight," Warner Bros., $460,166, 533 locations, $863 average, $31,537,914, 5 weeks.
18. "Fifty Shades Darker," Universal, $453,590, 607 locations, $747 average, $114,030,075, 6 weeks.
19. "Badrinath Ki Dulhania," Fox International Productions, $418,202, 156 locations, $2,681 average, $1,584,711, 2 weeks.
20. "Moana," Disney, $342,833, 264 locations, $1,299 average, $248,044,531, 17 Weeks.
Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by 21st Century Fox; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.
Copyright © The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Docetaxel With or Without Thalidomide in Treating Patients With Metastatic Prostate Cancer
Tracking Information | ||||
First Received Date ICMJE | March 2, 2007 | |||
Last Updated Date | March 14, 2012 | |||
Start Date ICMJE | December 1999 | |||
Primary Completion Date | Not Provided | |||
Current Primary Outcome Measures ICMJE | Not Provided | |||
Original Primary Outcome Measures ICMJE | Not Provided | |||
Change History | Complete list of historical versions of study NCT00020046 on ClinicalTrials.gov Archive Site | |||
Current Secondary Outcome Measures ICMJE | Not Provided | |||
Original Secondary Outcome Measures ICMJE | Not Provided | |||
Current Other Outcome Measures ICMJE | Not Provided | |||
Original Other Outcome Measures ICMJE | Not Provided | |||
Descriptive Information | ||||
Brief Title ICMJE | Docetaxel With or Without Thalidomide in Treating Patients With Metastatic Prostate Cancer | |||
Official Title ICMJE | Phase II Randomized Study of Docetaxel With or Without Thalidomide in Patients With Androgen-Independent Metastatic Prostate Cancer | |||
Brief Summary | RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Thalidomide may stop the growth of prostate cancer by stopping blood flow to the tumor. PURPOSE: Randomized phase II trial to compare the effectiveness of docetaxel with or without thalidomide in treating patients who have metastatic prostate cancer. |
Detailed Description | OBJECTIVES: I. Determine the efficacy of thalidomide with docetaxel in terms of clinical response in patients with androgen-independent metastatic prostate cancer. II. Compare the pharmacokinetics of docetaxel with or without thalidomide in these patients III. Determine whether any pharmacodynamic relationships exist between plasma concentrations and clinical activity or toxicity of these regimens in this patient population. IV. Compare changes in molecular markers of angiogenesis and markers of apoptosis after treatment with these regimens in these patients. PROTOCOL OUTLINE: This is a randomized study. Patients are randomized to one of two treatment arms. Arm I: Patients receive docetaxel IV over 30 minutes once weekly for 3 weeks. Arm II: Patients receive oral thalidomide daily beginning on day 2 and docetaxel IV over 30 minutes on days 2, 9, and 16. Treatment continues every 28 days in both arms in the absence of unacceptable toxicity or disease progression. Patients are followed every 2 months. PROJECTED ACCRUAL: A total of 75 patients (25 to arm I and 50 to arm II) will be accrued for this study within 18 months. |
Study Type ICMJE | Interventional | |||
Study Phase | Phase 2 | |||
Study Design ICMJE | Primary Purpose: Treatment | |||
Condition ICMJE |
Intervention ICMJE |
Study Arms | Not Provided | |||
Publications * | Sissung TM, Danesi R, Kirkland CT, Baum CE, Ockers SB, Stein EV, Venzon D, Price DK, Figg WD. Estrogen receptor α and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy. J Clin Endocrinol Metab. 2011 Feb;96(2):E368-72. doi: 10.1210/jc.2010-2070. | |||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
Recruitment Information | ||||
Recruitment Status ICMJE | Completed | |||
Enrollment ICMJE | Not Provided | |||
Completion Date | September 2003 | |||
Primary Completion Date | Not Provided | |||
Eligibility Criteria ICMJE | PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Histologically confirmed androgen-independent metastatic adenocarcinoma of the prostate Clinically progressive disease documented by at least 1 of the following: Two consecutively rising PSA levels (PSA at least 5.0) At least 1 new lesion on bone scan Progressive measurable disease If no prior surgical castration, serum testosterone must be less than 50 ng/mL and continue on gonadotropin-releasing hormone If receiving an antiandrogen and PSA level rising, must demonstrate a continued rise in PSA 4 weeks after stopping flutamide and 6 weeks after stopping bicalutamide or nilutamide No brain metastases --Prior/Concurrent Therapy-- Biologic therapy: No prior thalidomide Chemotherapy: No prior chemotherapy for metastatic prostate cancer No prior docetaxel Endocrine therapy: See Disease Characteristics Radiotherapy: Recovered from prior radiotherapy Surgery: See Disease Characteristics Recovered from prior surgery --Patient Characteristics-- Age: 18 and over Performance status: ECOG 0-1 Life expectancy: Not specified Hematopoietic: Absolute neutrophil count greater than 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin less than 1.0 mg/dL AST/ALT less than 2.5 times upper limit of normal (ULN) Alkaline phosphatase less than 2.5 times ULN Renal: Creatinine no greater than 1.5 mg/dL OR Creatinine clearance at least 40 mL/min Cardiovascular: No history of myocardial infarction within past 6 months No uncontrolled congestive heart failure or angina pectoris Other: No other prior active malignancy within the past 2 years except nonmelanoma skin cancer or carcinoma in situ of the bladder Fertile patients must use effective contraception at least 1 month prior to, during, and for 1 month after study |
Sex/Gender | Not Provided | |||
Ages | 18 Years and older (Adult, Senior) | |||
Accepts Healthy Volunteers | Not Provided | |||
Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects | |||
Listed Location Countries ICMJE | United States | |||
Removed Location Countries | ||||
Administrative Information | ||||
NCT Number ICMJE | NCT00020046 | |||
Other Study ID Numbers ICMJE | 000033 00-C-0033 CDR0000067602 |
Has Data Monitoring Committee | Not Provided | |||
U.S. FDA-regulated Product | Not Provided | |||
Plan to Share Data | Not Provided | |||
IPD Description | Not Provided | |||
Responsible Party | Not Provided | |||
Study Sponsor ICMJE | National Institutes of Health Clinical Center (CC) | |||
Collaborators ICMJE | Not Provided | |||
Investigators ICMJE |
Information Provided By | National Institutes of Health Clinical Center (CC) | |||
Verification Date | March 2012 | |||
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |


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Our annual Pancake Breakfast will be held on Sunday, March 29th! The event runs from 7 AM to 1 PM. For full details, please see our flyer. |
Save the date! The Oaklyn Fire Department will be having an exciting event on Friday, March 20th! We'll have full details on the event soon, so please stay tuned for more updates. |
The Oaklyn Fire Department will be participating in the Oaklyn Borough Tree Lighting event this Friday, December 5th, starting at 6:30 PM. For more information, check out our Facebook post here. |
On Monday night, OFD conducted further training at the vacant Barrington Travel property next to Amato Brothers. Topics covered were primary searches for trapped victims and "vent, enter, search" tactics. Thanks again to Amato Brothers for use of the building. Pictures from the training can be seen on our Facebook post here. |
The Oaklyn Fire Department responded to a house fire in Audubon today. Pictures from the incident can be seen on our Facebook post here. |
Streets at the Camden County Emergency Training Center in Lakeland were named for longtime Oaklyn Fire Chief and Camden County Chief Fire Marshal Dave Aron along with the late Audubon Fire Chief and successor to Aron as Camco Chief Fire Marshal Paul Hartstein at a ceremony at the academy on Wednesday, October 29th. Emceed by current Chief Fire Marshal Paul Sandrock, speakers included other fire officials, State Senator Donald Norcross, and Freeholder Scot McCray. The event was attended by several hundred firefighters from around the county. At the conclusion of the ceremony, families of each then went to the appropriate street on the complex to unveil the signs. Pictures from the event can be seen on our Facebook posts here and here. |
We will be having our Fire Prevention Open House tonight at our station from 7-9 PM. We will be doing live demonstrations, distributing fire prevention information, and handing out fun and educational items for the kids. |
We were part of the "Touch a Truck" event in Audubon at the Chick-Fil-A this afternoon. It's an activity that allows for kids to see different types of trucks up close, not just fire trucks. Audubon, Audubon Park, Haddon Hts., and Mt. Ephraim fire trucks were also there. To see pictures from the event, check out our Facebook post here. |
Today the OFD assisted the Audubon Park Fire Department with welcoming home one of their members, Andrew Galiano, who is a Lance Corporal in the United States Marine Corps and served in Afghanistan. Also assisting with this detail were the Warrior Watch Riders, the Audubon Fire Department, Collingswood Fire Department, Mt. Ephraim Fire Department, West Collingswood Heights Fire Company, Westmont Fire Company, and Haddon Township Police Department. To see pictures from the event, please see our Facebook post here. |
The OFD responded to a three-vehicle accident in front of the Wawa shortly after 1pm Tuesday. Our job is to take care of leaking fluids, like anti-freeze and transmission fluid, that leaks onto the highway and to provide a safe working environment for EMS personnel. We also assist EMS as needed. While nobody was pinned in their cars, it was best for EMS to safely package the victims for transport before removing them from their cars. None of the injuries appeared to be life-threatening, and six people were taken to area hospitals. The White Horse Pike was closed for about 90 minutes. Remember, if you see an accident or fire anywhere, don't assume that somebody else has called it in. Make it a point to call 911 to make sure. Do not immediately start shooting video with your phone! That didn't happen here, but we hear of this happening all too much. To see pictures from the incident, check out our Facebook post here. |


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Vendor: Microsoft
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The Little Giant 505378 5-MSPR is a submersible sump pump. It is designed for continuous dewatering and water transfer applications. This pump has a discharge size of 1". It has a 1/6 hp thermal overload protected motor. This Little Giant 505378 5-MSPR Sump Pump can pump 1,075 GPH at 1' head pressure. This pump comes with a 10' cord. The voltage needed to run this pump is 230V single phase. It has an epoxy-coated cast aluminum housing. For more details, you can refer to the specification sheet. The Little Giant 505378 5-MSPR Sump Pump is covered by a limited warranty for a period of 12 months. Little Giant has proven their excellence for over 70 years by producing reliable pump solutions, packaged system options, and accessories.
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text: Djalma was briefly played for Estrela da Amadora. In January 2002, he was back to Brazil for Sport Recife. He was then played for cross-town rival Santa Cruz, and left for Portugal again for Paços de Ferreira on 13 August 2004. With Rincón, Júnior and Djalma, the team won Liga de Honra and returned to Portuguese Liga. Djalma was signed by Gama on 26 July 2005 for the reminder of Campeonato Brasileiro Série B. On 6 July 2007, he was signed by PFC Cherno More Varna. In July 2008, he signed a one year contract with Central Sport Club, for Campeonato Brasileiro Série C. In May 2009, he signed a 4 month contract with Centro Limoeirense, for Copa Pernambuco. |


text:
May 23, 2007 - 9:00pm
Created by Bluestrike, Awakening is a Half-Life 2 single-player modification where you play as Adrian Shepard and set some things in motion, before Gordon Arrives at City 17. The mod has a intro and 5 levels, and takes the average player a hour to complete. It includes custom music, voices, textures and prop models.
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Half-Life 2: Awakening Mod
Wow that one sentence really makes me want to play.
Half-Life 2: Awakening Mod
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Half-Life 2: Awakening Mod
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text:
When people use the term "ministroke," what they're really often referring to is a transient ischemic attack (TIA).
A TIA is a temporary interruption of blood flow to part of the brain, spinal cord or retina, which may cause stroke-like symptoms but does not damage brain cells or cause permanent disability.
TIAs are often an early warning sign that a person is at risk of stroke. About 1 in 3 people who has a TIA goes on to experience a subsequent stroke. The risk of stroke is especially high within 48 hours after a TIA.
The symptoms of a TIA are similar to those of a stroke and include:
Symptoms of TIA usually last only a few minutes but may persist for up to 24 hours. Since the immediate signs and symptoms of TIA and stroke are identical, it's important to seek medical attention.
You may need various diagnostic tests, such as a magnetic resonance imaging (MRI) scan or a computerized tomography (CT) scan, to help determine what caused the TIA.
Depending on the underlying cause, you may need medication to prevent blood clots or a procedure to remove fatty deposits (plaques) from the arteries that supply blood to your brain (carotid endarterectomy).
Jerry W. Swanson, M.D.
Original article: http://www.mayoclinic.org/diseases-conditions/transient-ischemic-attack/expert-answers/mini-stroke/FAQ-20058390


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What is Section 245(i) of the Immigration Code and Do I Qualify?
immigration section 245(i), Arizona Immigration Lawyers, Ariano & Reppucci immigration help, Phoenix immigration law
Section 245 allows a person to become a permanent resident without leaving the U.S. through a process known as adjustment of status. Generally, you are barred from adjusting your status if you entered the U.S. without first being inspected by a Customs and Border Patrol (CBP) officer and you have either failed to maintain lawful status or have been unlawfully employed in the U.S. Section 245 is one of the few exceptions to this rule.
Section 245(i) was enacted in 1994 to allow persons who qualify for green cards, but not for adjustment of status, to be able to adjust their status if they were to pay a $1000 fine. Congress phased out section 245(i) of the law in January 14, 1998, but those who already qualified were grandfathered in. Alternatively, those who missed the January 14, 1998 deadline were ineligible to adjust status in the U.S. and would likely face a three or ten year ban before being allowed to apply abroad.
For a number of reasons Congress on December 15th, 2000 extended the grandfathering date to April 30, 2001. Therefore, under the old law, you must have had a visa petition or labor certification filed on your behalf before January 14, 1998 in order to qualify you for section 245(i). Under the new law, you may qualify for section 245(i) if a visa petition or labor certification was filed on your behalf after January 14, 1998, but on or before April 30, 2001, but only if you were physically present in the U.S. on December 21st, 2000. Physical presence in the U.S. on December 21st, 2000 could have been legal or illegal presence.
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From Wikipedia, the free encyclopedia
Shimoda may mean:
Places in Japan[edit]
- Shimoda, Shizuoka, a city in Shizuoka Prefecture
- Shimoda Ropeway, an aerial tramway which climbs Mount Nesugata
- Shimoda, Aomori, a town in Aomori Prefecture
- Shimoda Station, a railway station in Oirase, Aomori Prefecture
Other uses[edit]
- Siege of Shimoda (1590), in Shimoda, Shizuoka
- Shimoda bugyō, 19th-century Japanese title equivalent to commissioner, overseer or governor
- Shimoda Conference, series of unofficial dialogues between the United States and Japan
- Treaty of Shimoda (1855), between Japan and Russia
See also[edit]
- Ryuichi Shimoda v. The State, a court case by a group of five survivors of the atomic attacks on Hiroshima and Nagasaki
- The Judith of Shimoda, a play attributed to Bertold Brecht
This disambiguation page lists articles associated with the title Shimoda. If an internal link led you here, you may wish to change the link to point directly to the intended article. |


text:
Rapamune Side Effects
Generic Name: sirolimus
Note: This page contains side effects data for the generic drug sirolimus. It is possible that some of the dosage forms included below may not apply to the brand name Rapamune.
In Summary
Common side effects of Rapamune include: upper respiratory tract infection and urinary tract infection. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to sirolimus: oral solution, oral tablet
As well as its needed effects, sirolimus (the active ingredient contained in Rapamune) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking sirolimus, check with your doctor immediately:
More common:- Abdominal or stomach cramps or pain
- accumulation of pus
- anxiousness, unexplained
- backache
- black or red, tarry stools
- bleeding from the gums or nose
- blurred vision
- body aches or pain
- bone pain
- bruising
- burning or stinging of the skin
- burning while urinating
- burning, dry, or itching eyes
- burning, tingling, numbness, or pain in the hands, arms, feet, or legs
- change in mental status
- changes in skin color
- chest pain
- chills
- confusion
- convulsions (seizures)
- cough
- dark or bloody urine
- deafness
- decreased urine output
- decreased vision
- difficulty with breathing or swallowing
- dilated neck veins
- discharge from the eyes
- dizziness
- drowsiness
- dry mouth
- earache
- excessive tearing
- extreme fatigue
- eye pain
- facial hair growth in females
- faintness or lightheadedness when getting up from lying or sitting position
- fast, slow, or irregular heartbeat
- fever
- flushing or redness of the skin, especially on the face and neck
- general feeling of discomfort or illness
- increased hunger
- increased menstrual flow or vaginal bleeding
- itching, pain, redness, swelling, tenderness, or warmth on the skin
- lack or loss of appetite
- large, flat, blue, or purplish patches in the skin
- loss of sexual ability, desire, drive, or performance
- loss of voice
- muscle pain
- nasal congestion
- nausea or vomiting
- numbness or tingling around the lips, hands, or feet
- pain in the chest, groin, or legs, especially the calves
- painful cold sores or blisters on the lips, nose, eyes, or genitals
- pale skin
- prolonged bleeding from cuts
- rapid heartbeat
- rash
- red or dark brown urine
- redness or swelling in the ear
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- ringing in the ears
- runny nose
- sensation of pins and needles
- severe constipation
- severe vomiting
- severe, sudden headache
- slurred speech
- sore throat
- sores or white spots on the lips or in the mouth
- stomach pain or upset
- sudden decrease in the amount of urine
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- sudden, unexplained shortness of breath
- sweating
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area
- tremor
- ulcers on the lips or in the mouth
- unusual tiredness or weakness
- vision changes
- weakness or heaviness of the legs
- white patches in the mouth or on the tongue
- yellow skin and eyes
- Bloating
- change in size, shape, or color of existing mole
- hoarseness
- mole that leaks fluid or bleeds
- new mole
- pains in the stomach, side or abdomen, possibly radiating to the back
- skin ulcer or sores
- Abnormal wound healing
- headache
- hives or itching
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- nails loose or detached
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- swelling of the arms or legs
- yellow nails lacking a cuticle
Minor Side Effects
Some sirolimus side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:- Abnormal vision
- acne
- belching
- blistering, crusting, irritation, itching, or reddening of the skin
- burning feeling in the chest or stomach
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feeling
- constipation
- continuing ringing or buzzing or other unexplained noise in the ears
- cracked, dry, or scaly skin
- crying
- decrease in frequency of urination
- degenerative disease of the joint
- depersonalization
- diarrhea
- difficulty with moving
- difficulty with passing urine (dribbling)
- dysphoria
- ear pain
- enlarged abdomen or stomach
- euphoria
- excess air or gas in the stomach or intestines
- excessive muscle tone, muscle tension or tightness
- fear
- feeling sad or empty
- hearing loss
- heartburn
- inability to have or keep an erection
- increase in heart rate
- increased hair growth, especially on the face
- increased urge to urinate during the night
- indigestion
- irritation in the mouth
- joint pain or swelling
- leg cramps
- loss of bladder control
- loss of energy or weakness
- loss of interest or pleasure
- loss of strength
- lower abdominal or stomach pain
- muscle aches, pain, stiffness, or weakness
- nervousness
- pain in the back, ribs, arms, or legs
- pain or burning in the throat
- pain or tenderness around the eyes and cheekbones
- paranoia
- pelvic pain
- quick to react or overreact emotionally
- rapid breathing
- rapidly changing moods
- inflammation, redness, or swelling of the gums or mouth
- shaking or trembling
- shivering
- sleepiness
- sunken eyes
- swelling
- swelling of the scrotum
- tender or enlarged gums
- tenderness in the stomach area
- thickening of the skin
- trouble concentrating
- trouble sleeping
- waking to urinate at night
For Healthcare Professionals
Applies to sirolimus: oral solution, oral tablet
Very common (10% or more): Dyspnea (up to 30%), upper respiratory infection (up to 26%), pharyngitis (up to 21%)
Common (1% to 10%): Pneumonia, epistaxis, pleural effusion, epistaxis
Uncommon (0.1% to 1%): Pulmonary hemorrhage
Rare (less than 0.1%): Alveolar proteinosis
Frequency not reported: Pleural effusion, alveolar proteinosis[Ref]
Very common (10% or more): Hypertriglyceridemia (up to 58%), hypercholesterolemia (up to 46%), hypokalemia, hypophosphatemia, hyperglycemia
Common (1% to 10%): Abnormal healing, increased lactic dehydrogenase (LDH), hypokalemia, diabetes mellitus[Ref]
Very common (10% or more): Peripheral edema (up to 58%), hypertension (up to 49%), chest pain (up to 24%), edema (up to 18%), lymphocele
Common (1% to 10%): Venous thromboembolism (including pulmonary embolism, deep venous thrombosis), tachycardia
Uncommon (0.1% to 1%): Pericardial effusion (including hemodynamically significant effusions in children and adults), lymphedema
Rare (less than 0.1%): Pericardial effusion[Ref]
Very common (10% or more): Constipation (up to 38%), abdominal pain (up to 36%), diarrhea (up to 35%), nausea (up to 31%), vomiting (up to 25%), dyspepsia (up to 25%)
Common (1% to 10%): Stomatitis[Ref]
The most common adverse reactions associated with this drug are peripheral edema, hypertriglyceridemia, hypertension, hypercholesterolemia, creatinine increased, constipation, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, arthralgia, pain, and thrombocytopenia.[Ref]
Very common (10% or more): Anemia (up to 33%), thrombocytopenia (up to 30%), blood lactate dehydrogenase increased, blood creatinine increased
Common (1% to 10%): Thrombocytopenic purpura/hemolytic uremic syndrome, leukopenia, neutropenia, aspartate aminotransferase increased, alanine aminotransferase increased
Uncommon (0.1% to 1%): Pancytopenia
Frequency not reported: Capillary leak syndrome[Ref]
Very common (10% or more): Urinary tract infection (up to 33%)
Common (1% to 10%): Pyelonephritis, decline in renal function (creatinine increased) in long-term combination of cyclosporine with this drug, ovarian cysts, menstrual disorders (including amenorrhea and menorrhagia), proteinuria
Postmarketing reports: Azoospermia[Ref]
Very common (10% or more): Arthralgia (up to 31%)
Common (1% to 10%): Bone necrosis[Ref]
Nervous system
Very common (10% or more): Headache (up to 34%)
Common (1% to 10%): Osteonecrosis, tremor, insomnia[Ref]
Very common (10% or more): Acne (up to 22%), rash (up to 20%)
Common (1% to 10%): Herpes zoster, herpes simplex
Uncommon (0.1% to 1%): Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), leukopenia, melanoma, squamous cell carcinoma, basal cell carcinoma[Ref]
Very common (10% or more): Creatinine increased (up to 40%)
Uncommon (0.1% to 1%): Nephrotic syndrome
Frequency not reported: Focal segmental glomerulo-sclerosis, BK virus associated nephropathy, nephrotic syndrome, higher serum creatinine levels, lower glomerular filtration rates[Ref]
Frequency not reported: Eyelid edema[Ref]
Common (1% to 10%): Liver function tests abnormal
Frequency not reported: Hepatic failure, hepatic artery thrombosis[Ref]
Rare (less than 0.1%): Hypersensitivity reactions, including anaphylactic/ anaphylactoid reactions, angioedema, exfoliative dermatitis, and hypersensitivity vasculitis[Ref]
Very common (10% or more): Fever (up to 34%), pain (up to 29%)
Common (1% to 10%): Impaired healing[Ref]
Common (1% to 10%): Skin cancer, lymphoma/post-transplant lymphoproliferative disorder
Frequency not reported: Hepatocellular adenoma and carcinoma, testicular adenoma[Ref]
Common (1% to 10%): Sepsis, pneumonia, pyelonephritis, herpes simplex, fungal, viral, and bacterial infections (such as mycobacterial infections, including tuberculosis, Epstein-Barr virus, CMV, and Herpes zoster), mycobacterial infections (including M tuberculosis), cytomegalovirus (CMV), Epstein-Barr virus
Frequency not reported: Clostridium difficile enterocolitis[Ref]
1. Sola E, Lopez V, Burgos D, et al. "Pulmonary toxicity associated with sirolimus treatment in kidney transplantation." Transplant Proc 38 (2006): 2438-40
2. "Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):
5. Vlahakis NE, Rickman OB, Morgenthaler T "Sirolimus-associated diffuse alveolar hemorrhage." Mayo Clin Proc 79 (2004): 541-5
6. Wheatcroft S, Byrne J, Thomas M, MacCarthy P "Life-threatening coronary artery spasm following sirolimus-eluting stent deployment." J Am Coll Cardiol 47 (2006): 1911-2; author reply 1912-3
7. Alkhatib AA "Sirolimus-induced intractable chronic diarrhea: a case report." Transplant Proc 38 (2006): 1298-300
8. Altomare JF, Smith RE, Potdar S, Mitchell SH "Delayed gastric ulcer healing associated with sirolimus." Transplantation 82 (2006): 437-8
9. Aboujaoude W, Milgrom ML, Govani MV "Lymphedema associated with sirolimus in renal transplant recipients1." Transplantation 77 (2004): 1094-6
10. Josef F, Marina K, Alois W "Sirolimus myopathy." Transplantation 76 (2003): 1773-4
11. Mohaupt MG, Vogt B, Frey FJ "Sirolimus-associated eyelid edema in kidney transplant recipients." Transplantation 72 (2001): 162-4
12. Neff GW, Ruiz P, Madariaga JR, et al. "Sirolimus-associated hepatotoxicity in liver transplantation." Ann Pharmacother 38 (2004): 1593-6
It is possible that some side effects of Rapamune may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Rapamune (sirolimus)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 0 Reviews – Add your own review/rating
- Generic Availability
- Drug class: mTOR inhibitors
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