text:
The upper cervical spine is defined by the two most cephalad cervical vertebrae, C1 (the atlas) and C2 (the axis). This region is distinct in anatomic shape and is more mobile than the lower cervical spine, the subaxial cervical spine. The occipital condyles of the head (or the globe) rest upon the lateral masses of C1 (the atlas). These articular facets allow most of the flexion and extension of the head on the neck as the occipital condyles articulate on the atlas. [1, 2, 3, 4]
The ring of C1 has no vertebral body; the vertebral body that would correspond to C1 is connected or contiguous with the vertebral body of C2 and projects up as the dens (the tooth), also known as the odontoid of C2 (the axis). Most of the lateral rotation of the neck actually occurs at the C1-2 junction; the remaining motion of the cervical spine is distributed among the subaxial spine vertebral motion segments as a fractional amount (~7%) per level and is less in total than the C1-2 lateral rotation.
This area of the upper cervical spine is extremely mobile, and its stability is dependent on ligamentous structures. In unresponsive patients or those who are unable to report symptoms or pain, a C1 fracture or an occipital cervical dislocation must be excluded by radiographic screening. Also, displacement of the C1 ring may occur if the capsule or ligaments are disrupted, even without a C1 fracture; hence, the head may be displaced on the neck, and the atlas may also rotate around the odontoid or sustain a fracture of the dens.
History of the Procedure
Jefferson originally described this type of C1 fracture in 1920. [5] The principal treatment is with a halo and vest or cast, which remains an effective current treatment for many of these fractures.
The C1 vertebra (atlas) is a closed ring. A fracture of a closed ring necessarily results in at least two areas of ring disruption. These disruptions are customarily accompanied by a spread of the C1 ring fragments as a result of the axial loading mechanism of this injury and the weight of the head.
In addition to anteroposterior and lateral views, radiographs of the upper cervical spine include the open mouth view. This view may identify spreading or widening of the lateral masses or asymmetry of the separation of the odontoid from the lateral masses, which, in an appropriately centered radiograph, may be consistent with spreading of the C1 ring or a C1 fracture. Increased overhang of the lateral masses over the C2 facet totaling more than 6.9 mm suggests a fracture with disruption of the transverse odontoid ligament that may otherwise constrain displacement.
Fractures of the ring of C1 may be associated with an odontoid fracture; thus, the combination of the two fractures should be considered. Furthermore, congenital anomalies of the arch (eg, agenesis of the posterior ring) may be present. Anterior subluxation of C1 on C2 may be present and, if so, often indicates a disruption of the transverse odontoid ligament.
Fractures of the atlas account for 25% of atlantoaxial complex bony injuries, 10% of cervical spine injuries, and 2% of all spine injuries. Injury to the cervical spine occurs infrequently in pediatric populations, and although C1 represents only 1-2% of pediatric trauma and 2-10% of all cervical injuries in this population, the associated mortality is 16%.
The Jefferson fracture most commonly occurs as the result of axial loading on the head through the occiput, leading to a burst-type fracture of C1. Diving is the most frequent cause of this fracture, when it results from striking the head on an obstacle in shallow water; hence, the national program "Feet first, first time" (North American Spine Society, 2005) provides a motto for diving in unknown waters or shallow collections of water and has been an effective deterrent.
The next most frequent cause of this fracture is being thrown up against the roof of a motor vehicle, a car or bus, or even an aircraft, and the forces are distributed to the body through the neck. The third most frequent cause of these injuries is falls onto the head, except in toddlers, who are predisposed to injury from falls because of their disproportionate head size. [1]
Less frequently, when a significant rotatory force is exerted, an atlanto-occipital junction dislocation may occur, or the force may also be dissipated through the odontoid as an associated fracture.
The ring of C1 is a structural member of the cervical spine. Because it is a ring and because fracture results in disruption of this ring, more than one location is affected.
The fragments have a propensity to shift laterally, from both the weight of the head and the muscular contraction acting through this articulation; thus, occipital condylar support for the head is lost. The absence of the rigid bony structure and the lack of interconnection or interrelation of the attached ligamentous structures meet the definition of instability, particularly as the bony protective function of C1 for the neural elements is lost.
Vertebral artery injuries have been reported as a result of C1 fractures, especially with atlanto-occipital dislocations; small excursions of displacement can be fatal. In addition, vertebral artery injuries can occur and have been reported in the absence of severe trauma as a result of cervical traction, chiropractic manipulation, overhead work, or yoga exercises. Hyperextension is customarily accompanied with rotation; when this is not limited by normal restraints, it becomes excessive, severely diminishing blood flow through the vertebral arteries.
This diminished blood flow is particularly a problem in the posterior inferior cerebellar artery and may result in Wallenberg syndrome, which is characterized by ipsilateral loss of cranial nerves V, IX, X, and XI with cerebellar ataxia.
Horner syndrome may occur and, in some cases, may involve contralateral loss of pain and temperature sensation; involvement can extend up from a lateral medullary infarct and spread to the basilar superior cerebellar or the inferior cerebral artery, leading to sudden death, quadriplegia, and the locked-in syndrome, in which quadriplegia occurs with loss of lower cranial nerves and only eye-blinking is possible.
Patients customarily present with a history of trauma and a symptom of pain in the neck. Amid the massive number of patients who qualify as having this history and symptom, a few patients have an unstable C1 injury and may present neurologically intact, but they are at grave risk for neurologic compromise if not promptly diagnosed and appropriately stabilized and treated.
Patients with a complete spinal cord injury and no neurologic function continue to have only sensation on the face and motor control of the facial muscles from the cranial nerves. A tracheostomy is essential; the patient requires respiratory assistance and a volume respirator. If the C3-5 area is intact, the phrenic nerve may often be stimulated to contract the diaphragm. If stimulation of the phrenic nerve does not contract the diaphragm, then the spinal cord is no longer functioning; the cell body is dead, and a phrenic electrical stimulator is not effective.
Recognition and identification of a Jefferson fracture is the indication for treatment. Treatment consists of spinal stabilization to protect the patient from further nerve damage, including that to the brainstem. Children may represent less unstable cases, presumably because of periosteal stability, and they are often treated with a collar. The body of C1 is not visible radiographically until age 1 year.
Even in the absence of a C1 fracture, assessment of stability must include the associated structures. An atlanto-occipital dislocation or disruption and C1-2 instability, particularly when the transverse ligament may be disrupted, poses severe risk to the brainstem and upper spinal cord. Furthermore, with a C1 fracture, associations exist with unstable injuries such as odontoid fractures and other injuries to the upper cervical spine. In addition, the odontoid fragment may migrate into the foramen magnum, endangering the brainstem and upper spinal cord.
Specific treatment should be based on analysis of the mechanism and extent of the injury. In a younger patient with limited displacement of the C1, immobilization with a collar or halo and vest may be adequate.
In more severe cases, particularly with associated injuries such as odontoid fracture, bypassing the C1 ring with an occipital-to-cervical fusion extending to C2 or lower may be necessary. Instrumentation spanning that area may stabilize the C1 ring, which otherwise cannot easily be addressed directly, because both the anterior and posterior components of the ring are disconnected by the fracture and are not amenable to instrumentation or direct repair.
Relevant Anatomy
The care of any fracture requires attention to the joint above and below. This cervical complex has often been treated as two separable articulations, C0-1 and C1-2, but the three-unit occipitoatlantoaxial complex (C0-C1-C2) articulation is much more functionally relevant.
The significance is the proximity to the brain, brainstem, and upper cervical spinal cord, but that is contrasted with the very significant motion that occurs in this area. Although patients are routinely asked to flex and extend their necks to determine range of motion, some of that motion observed is between the occiput and the atlas, and as the patient rotates laterally, at least 50% of that motion is atlantoaxial.
The stability of the injury depends on the ligaments between the bony structures. On the frontal view, the projecting occipital condyles are supported by the lateral masses (observed as wedges, narrow medially and expanding laterally), resting on the corresponding superior articular surface of the axis (C2). Consequently, the lateral masses provide inherent stability because of this bony shape and also illustrate the extent of the instability when this bony structure is disrupted, particularly when these wedges displace laterally.
The projecting condyles of the occiput are stabilized with the occipitoatlantal capsule, as well as anterior and posterior atlanto-occipital membranes. The ligamentum nuchae is a significant stabilizing structure; its specific relevance to the atlanto-occipital axial complex is controversial but should be considered. Connections from the occiput to the axis are the tectorium membrane and the alar and apical ligaments, which do not appear to be bulky enough to be independently significant restraints.
The dentate ligaments (ie, the alar ligament and the apical ligaments) attach to the dorsal lateral surface of the dens and run obliquely to the medial surfaces of the occipital condyles. In 1974, Anderson and D'Alonzo classified a type 1 odontoid fracture as an avulsion fracture of the odontoid tip caused by the apical ligament, suggesting that these ligaments impart a significant degree of stability. A modified, treatment-oriented classification of odontoid fractures has been presented to expand the Anderson-D'Alonzo classification, but further assessment is needed. [6]
The transverse ligament goes from the medial surface of one side of the atlas to the other side and essentially constrains the axis to rotate around the odontoid in a closed ring of bone and the transverse ligament. As a consequence, the atlas can displace and embarrass the brainstem and spinal cord if this ligament ruptures or if an associated fracture of the odontoid is present as a result of this specific anatomic arrangement.
No significant contraindications to treatment exist, because the lack of stabilization, which commonly is initially provided either with traction or with a halo brace, can have fatal consequences. Any contraindications are mitigated by the potential for serious and even fatal neurologic consequences without treatment, as well as by the observation that halo with vest or traction can be relatively effective in immobilizing the upper cervical spine, with low associated morbidity.


text:
KBND Morning News
6:00am - 9:00am
Listen Live
Posted: 2012-11-13 19:43:00 by KBND News Sources
A freshman at Beaverton High School has lost a battle with a rare form of thyroid cancer. Maddy Lauer was 14 years old. In October, she was crowned homecoming queen. Her mom says news it was the thrill of her life, and happened at just the right time. Her friends tied hundreds of purple ribbons; the color used to honor thyroid cancer victims, and they were handed out to students Tuesday morning.

subset: commoncrawl


text:
Video Information
Description: Sweet amateur couple having a great homemade sex this horny brunette babe gave her partner an awesome massive deep throat blowjob that made her muscular partners dick very hard and ready to fuck her pussy this muscle man started to fuck his girl from behind while smashing her natural titties that makes her partner moan like crazy until he received a massive blowjob again after he laid down in a bed his partner started to ride his hard cock now and act like a cowgirl she turn around to feel more his hard cock sliding in and out to her tight wet pussy
Runtime: 7 minutes and 44 seconds
Production: Amateur
Categories: Webcam, Amateur, Cock
Content: Straight, English
Popular: - More Popular videos.
Pornstars: No
Mobile: No
Tags: Cums
Profile Information
Playlist information
Comments . 0 ▼
Related Videos from hotjhen
Tatti Sizzling Hot Busty Cam Babe
Gorgeous brunette chick dildo fuck her wet pussy. she is...
497 Views · 0 Ratings · 0 CommentsSizzling Hot Beautiful Babe Masturbate To Orgasm
Sizzling hot and seductive sexy webcam beautiful girl...
12 Views · 0 Ratings · 0 CommentsSizzling Hot Solo Masturbation Of Horny Slut
You should watch this sexy hot amateur brunette slut that...
28 Views · 0 Ratings · 0 CommentsLatino lovers fucking so hot
Watch this latino lovers how hot there sex in webcam....
13 Views · 0 Ratings · 0 CommentsHot Blonde Teen Dildo Fucking on Cam
Sexy blonde babe with a great body and a nice breast...
8 Views · 0 Ratings · 0 Comments


text:
Les Lucarnes
Les Lucarnes
Heavy weight duo fabric biker style leggings. MADE IN CANADA Main fabric: 60% Cotton, 35% Nylon, 5% SpandexSecond fabric: 100% Polyester
Two words come to mind when we think of the Vancouver-based online store: girl power. In 2013, Christina Heemskerek and Shannon Heth took their friendship to the next level and opened an online boutique featuring fun and feminine wares. Their MO? Using fashion as a form of empowerment and celebrating personal style. "Remember: don't be the world's version of perfect... that sh*t is boring."


text:
AdvertisementGame name:Elsa And Anna HairstylesGame description Princesses Elsa and Anna were too busy restoring the kingdom after the magical winter and had no time for caring about themselves. Now the sisters discovered, that their hair looks tired and messy. They desperately need to visit your hair salon! Create perfect royal hairstyles for Elsa and Anna. Use your mouse to create hairstyles for Elsa and Anna. |
Sitemap | Privacy Policy | Cookie policy | Free Online Games
2016-2017 www.PlayoGames.Com |


text:
Skip to content
Our website uses cookies. By continuing we assume your permission to deploy cookies, as detailed in our cookies policy.
0330 123 2023
Studied: BA (Hons) Sports ManagementRole: Community Sports Development Manager at Freedom Leisure
From having career ambitions in sport to running with them...
Freedom Leisure manages leisure sites and entertainment venues across Sussex, Surrey and Kent for partners including local authorities, colleges and charities. A not-for-profit trust, their income is invested back into their centres to provide even better leisure services for their communities.
"I knew I wanted to work in sport but I wasn't 100% sure in what area. So, once I discovered that sports management covered all aspects, Bucks was the obvious choice. It also helped that the university was so close to London.
"For me, the best thing about studying for the Sports Management course was the psychology module which I really enjoyed. I liked that there were plenty of opportunities available to me through the university - which were all relevant to the course.
"Since graduating, I've been lucky enough to find a job in my chosen career path - sports development. And much of what I do in my job today is directly from what I learnt on the course, particularly the Sports Management Finance module.
"In that respect, the course has definitely helped me to enhance my career prospects. One day I'd like to work within a different field of sports development to gain even more experience, such as for a National Governing Body of sport.
"I'd highly recommend Bucks New University to study your degree. They have a wide range of courses on offer and the lecturers are so helpful. I had an amazing three years at Bucks and wish I could do it again!"
*All information on this page was correct at time of publishing.


text:
Information local to Exeter
Need a local Exeter estate agent, to find out the local weather, see what public services are available, read some visitor reviews, or find a local Exeter business. This page provides a connection to lots of things local for the Exeter resident or visitor. Why not try the Exeter Directory - a growing catalogue of entries for topics including shopping to sports.
Whatever your budget, whatever the occasion - you'll find most of what Accommodation Exeter has to offer right here from Hotels to Guest Houses....
Shops to satisfy everybody's taste from luxury to quirky - The City is becoming the region's favourite with ongoing developments that's attracting the very best in retail....
Are you looking for area attractions, a night out in the city, or may be a little history - There's lots of places to see and things to do in Exeter....
Dates for your diary
From the Exeter events calendar:
On the blog!
The latest post on the Exeter Blog:
Keep up to date
You can get the latest from ExeterViews by following us on Twitter, Google+, Facebook and on the Exeterviews.co.uk Blog


text:
One protester has died and several others have been injured in Tunisia after radical Islamists defied a ban on their demonstration and clashed with police.
The 27-year-old man was killed in the capital; there was also trouble in the central city of Kairouan.
In Tunis police arrested dozens of people in one district. In the midst of the clashes some of the protesters reportedly lowered the Tunisian flag and replaced it with an al Qaeda banner.
The Salafist group Ansar al-Sharia is the most radical to emerge since the revolution two years ago.
It had wanted to demonstrate in Kairouan where but was forbidden from doing so. The ban did not stop the protesters: they threw stones at police who responded with tear gas.
The demonstrators' cause gained no sympathy among one group of Kairouan residents. "Why would we want an Islamist state? Earning a living, security and stability, that's what the Arab world needs!" exclaimed one man.
In Tunis a police union official said: "We're here to stop their behaviour. We'll stay for a month if need be. The law must be respected."
Ansar al-Sharia presents a clear challenge to Tunisia's government, led by the more moderate Islamists from Ennahda. The Prime Minister Ali Larayedh claimed on Saturday that the group is linked to terrorism.
Al Qaeda's regional wing has urged it to defy the crackdown.
All views
Get a different perspective
Every story can be told in many ways: see the perspectives from Euronews journalists in our other language teams.


text:
A federal appeals court has refused to reconsider a decision allowing residents of Kansas and Arizona to register to vote using a federal form without providing proof of their U.S. citizenship.
Read More »Court stays voter citizenship proof requirement
Kansas and Arizona residents can continue to register to vote for now using a federal form without having to provide proof of citizenship, a federal appeals court ruled Thursday.
Read More »Advocates vow appeal of latest ruling in fight over Arizona voter law
A federal judge's order backing Arizona and Kansas laws that require proof of citizenship for voter registration is "not the American way" and must be challenged, opponents said Thursday.
Read More »


text:
26:37 Compilation of Japanese Close-ups 94% 469,554 99:19 Tied Up Japanese Chick Fucked 95% 218,156 82:09 Do what I say and shut up 95% 421,714 |
| ||||||
Comentários (22)
Positively outstanding selection! Brest I've seen! Should have sub-titles for those who don't understand the lingo. Great photography. Every hetero man's dream! I want to taste test each pussy and asshole to compare the taste. Whom ever taste the best, I will eat the rest then cum back to her. so many beautiful girls, nice closeup movie !!! would love to taste there ass one after another, yummy !!! | |||||||||||||||||||||
Select video quality |


text:
Gregg Gillis, better known as electronic mash-up maestro Girl Talk, releases his fifth album today. Like his previous releases, Gillis combines popular songs from the past several decades to make a danceable, hour-long assortment of hip-hop, rock and everything inbetween. The album is meant to be listened to as a whole but can also be downloaded in separate mp3 files to better navigate.
Gillis will also soon be embarking on a nationwide tour next year for All Day. If you haven't ever been to a Girl Talk show before, it is highly recommended.
Here's a tracklist, not that it will help:
1. Oh No
2. Let It Out
3. That's Right
4. Jump on Stage
5. This Is the Remix
6. On and On
7. Get It Get It
8. Down for the Count
9. Make Me Wanna
10. Steady Shock
11. Triple Double
12. Every Day


text:
Que Hermosa niña
I like Nick Twin's videos so far, if more of his features were to appear here I would be quite happy. Although this would have been soooooo much better if a slide show of those selfies Ryana snapped had been included at the end of the video.
Those selfies would have been hot!
very nice


text: News Iron Sky posts $116k opening weekend as Avengers stays top May 15, 2012 9:19 by Colin Delaney 0 Nazi science fiction film Iron Sky has posted a $116,000 opening weekend at the box office. Distributed by Hoyts, the Australian/German/Finnish co-production was backed by an online marketing campaign that saw the first teaser going online 4 may 2008 and a crowd-funding model that got the producers $1.28m towards the budget. The Finnish production company, Blindspot Pictures and director Timo Vuorensola also used its online fan-base from previous sci-fi comedy, Star Wreck to create interest. The film's $116,000 came from 45 screens with an average of $2,585 per screen, according to Motion Picture Distributors Association of Australia. To date the film has taken $US7m worldwide with $US4.177m of that coming from Germany off the back of its world premiere at the Berlin International Film Festival and $US2.044m in Finland, according to Box Office Mojo. Co-produced by Australia's New Holland Pictures and shot on the Gold Coast, the film is about Nazis who abandon Earth for the dark side of the moon after WWII, with plans to one day return and take over the planet. The film was third on the limited release top 20 films behind The Way in number two spot, and in its third week at number one, Australian film Wish You Were Here, which took $154,000 across 43 screens for an average of $3,593. The Hopscotch/eOne film has taken $875,000 to date. In the major release, The Avengers was yet again in its third week the top grossing film of the weekend, taking $5.198m across 617 screens for an average of $8,425. Meanwhile Dark Shadows, the Tim Burton vampire film starring Johnny Depp, opened with $3.728m across 369 screens for an average of $10,105 while the Jason Stratham film Safe opened with 443,000 across 140 screens for an average of $3,163. ADVERTISEMENT


text:
Hot Rod Classic Cars 1920×1080, Published by adam. This wallpaper was added in Wednesday, June 05, 2013 - 11:03 pm and 13 users has viewed and downloaded this wallpaper. Approximately 1,80 MB bandwith was consumed.
All you need to do is help us grow by sharing this Hot Rod Classic Cars 1920×1080 wallpaper if you like it.
Please use one of the links below to download the high resolution of Hot Rod Classic Cars 1920×1080, for free! Use this Wallpaper on your Ipad, Tablet, Smartphone or Desktop.
Setting a wallpaper as a background on your desktop is simple. Once you have clicked 'Full Size Edit & Download' you will be taken to the full sized Hot Rod Classic Cars 1920×1080 please right click that Wallpaper image and "Save Image As" or if the option is available "Set as background"
Hot Rod Classic Cars 1920×1080 - Picture Details


text:
By Marketwired . | Article Rating: |
November 14, 2012 08:17 PM EST | Reads: |
1,339 |
SANTA CLARA, CA -- (Marketwire) -- 11/14/12 -- Document Capture Technologies, Inc. (OTCBB: DCMT), an IP-driven leader in the design, development, manufacture and sale of advanced imaging technologies for over a decade, today announced Q3 2012 sales of $4.1 million, down 22% as compared to Q3 2011 which was favorably impacted by the fulfillment of a single large order during the period. Excluding the impact of the record order in Q3 2011, DCT's sales in Q3 2012 would have been up slightly as compared to Q3 2011. Sales for the nine months ending September 30, 2012 increased by 4% to $13.1 million over the same period in 2011.
DCMT reported gross profit of $1.4M during Q3 2012, down 31% as compared to Q3 2011. Gross profit margin of 34% in Q3 2012 decreased from 39% in Q3 2011, due to the mix of products sold. In both cases, the gross margin comparison is impacted by inclusion of the large order shipped in Q3 2011.
Total operating expenses during Q3 2012 remained consistent at $1.8 million as the Company continues its strategic investment spending in personnel and R&D to fuel growth and product expansion. R&D expenditures increased by 55% in Q3 2012 as compared to Q3 2011. SG&A expense as a percentage of sales increased to 32% in Q3 2012 as compared to 28% in Q3 2011, and total operating expense as a percentage of sales increased to 43% in Q3 2012 as compared to 33% in Q3 2011. The large order fulfilled for one customer during Q3 2011 impacted the comparison of operating expenses as a percentage of sales.
Q3 2012 EBITDA* (earnings before interest, taxes, depreciation and amortization) was ($119,000) versus $640,000 for the same period in 2011, a decrease of $759,000.
DCT ended Q3 2012 with a strong financial position, reporting no debt, working capital in excess of $5.5 million, and an available borrowing capacity on its bank line of credit of over $1.9 million.
As part of its IP strategy in the area of security, DCT invested in Advanced Cyber Systems Corp ("ACSC") in Q3 2012. ACSC is focused on technology that can assess, analyze and advise on security threats associated with mobile web applications, websites and e-commerce systems. The investment is evidence of our commitment to expedite DCT's evolution into a mobile and cloud-centric solutions provider while emphasizing document and data capture in a secure environment. "We are excited about the possibilities of combining ACSC's expertise in security technologies with DCT's end to end solutions strategy going forward," said David P. Clark, Chief Executive Officer of Document Capture. "DCT's continued strong financial position has enabled us to expand our R&D efforts, and we continue to add value to our legacy hardware as well as develop the next generation of smart device capture and secure scan-to-cloud solutions."
Document Capture's patented technology provides high quality images at extremely low power consumption levels in a compact package. Easy to use, DCT's products are adaptable to a wide variety of businesses. DCT's standard software supports drivers for Windows 7/Vista/XP, Windows CE, Linux and the MAC OS. DCT also offers a more customized product, with proprietary software development tools that help integrate its document capture products with new and existing applications.
Conference Call Details
Interested participants should register for the call 10 minutes prior to 4:30 pm Eastern on November 19, 2012. Dial 877-407-8035 when calling within the United States, or 201-689-8035 when calling internationally.
Following the call, there will be an open question and answer session with the participants.
Playback will be available until January 23, 2013. To listen to the playback, dial 877-660-6853 when calling within the United States, or 201-612-7415 when calling internationally. Use Account number 286 in conjunction with replay ID number 404026.
This conference call is also available via webcast and can be accessed by clicking here.
About Document Capture Technologies
Document Capture Technologies (OTCBB: DCMT) is a worldwide leader in the design, development, manufacturing, and sale of USB powered mobile page-fed document capture platforms. DCMT provides more than 30 different products across five distinct categories, which are distributed globally through private label solutions to leading Tier 1 OEMs, VARs and other system integrators, including NCR, Qualcomm, Digital Check, Burroughs and Brother.
For additional information, please see Document Capture Technologies' corporate website: www.docucap.com.
This press release is neither an offer to sell nor the solicitation of an offer to buy any securities of DCMT.
Forward-Looking Statements
Statements contained in this press release, which are not historical facts, are forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These forward-looking statements are based largely on current expectations and are subject to a number of known and unknown risks, uncertainties and other factors beyond the Company's control that could cause actual events and results to differ materially from these statements. These risks include, without limitation, that there can be no assurance that any strategic opportunities will be available to the Company and that any strategic opportunities may only be available on terms not acceptable to the Company. These statements are not guarantees of future performance, and readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release. DCMT undertakes no obligation to update publicly any forward-looking statements.
*The Company is providing a non-generally accepted accounting principles financial measure, EBITDA (specifically defined by the Company as operating earnings before interest, taxes, depreciation included in operating expenses and amortization), because (i) the Company believes that this figure is helpful in allowing individuals to assess the ongoing financial performance of the business; (ii) the Company uses EBITDA, along with other GAAP measures, as a measure of profitability because EBITDA helps the Company compare its performance on a consistent basis by removing from its operating results the impact of non-cash expenses; and (iii) non-GAAP performance measures provide an additional analytical tool to clarify the Company's results from operations and helps the Company to identify underlying trends in its results of operations.
EBITDA is a non-GAAP measure and has limitations because it does not include all items of income and expense that impact the Company's operations. Management compensates for these limitations by also considering the Company's GAAP results. The non-GAAP financial measure the Company uses is not prepared in accordance with, and should not be considered an alternative to, measurements required by GAAP. Following is a reconciliation of operating loss to EBITDA (in thousands):
Three Months Ended Nine Months Ended September 30, September 30, ------------------ ------------------ 2012 2011 2012 2011 -------- -------- -------- -------- Operating (loss) income $ (374) $ 285 $ (861) $ (637) Adjustments: Depreciation included in operating expenses 11 11 31 36 Stock-based compensation cost - options 224 325 727 971 Fair value of common stock and warrants issued for services rendered 20 19 59 60 -------- -------- -------- -------- EBITDA $ (119) $ 640 $ (44) $ 430 ======== ======== ======== ========
Add to Digg Bookmark with del.icio.us Add to Newsvine
David Clark
Email Contact
Published November 14, 2012 Reads 1,339
Copyright © 2012 SYS-CON Media, Inc. — All Rights Reserved.
Syndicated stories and blog feeds, all rights reserved by the author.
More Stories By Marketwired .
Copyright © 2009 Marketwired. All rights reserved. All the news releases provided by Marketwired are copyrighted. Any forms of copying other than an individual user's personal reference without express written permission is prohibited. Further distribution of these materials is strictly forbidden, including but not limited to, posting, emailing, faxing, archiving in a public database, redistributing via a computer network or in a printed form.
SYS-CON Events announced today that MobiDev, a client-oriented software development company, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place June 6-8, 2017, at the Javits Center in New York City, NY, and the 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. MobiDev is a software company that develops and delivers turn-key mobile apps, websites, web services, and complex softw... Mar. 30, 2017 02:15 AM EDT Reads: 4,094 |
By Yeshim Deniz DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm. Mar. 30, 2017 01:30 AM EDT Reads: 2,617 |
By Elizabeth White What sort of WebRTC based applications can we expect to see over the next year and beyond? One way to predict development trends is to see what sorts of applications startups are building. In his session at @ThingsExpo, Arin Sime, founder of WebRTC.ventures, will discuss the current and likely future trends in WebRTC application development based on real requests for custom applications from real customers, as well as other public sources of information, Mar. 30, 2017 01:15 AM EDT Reads: 1,217 |
By Pat Romanski DevOps tends to focus on the relationship between Dev and Ops, putting an emphasis on the ops and application infrastructure. But that's changing with microservices architectures. In her session at DevOps Summit, Lori MacVittie, Evangelist for F5 Networks, will focus on how microservices are changing the underlying architectures needed to scale, secure and deliver applications based on highly distributed (micro) services and why that means an expansion into "the network" for DevOps. Mar. 30, 2017 01:00 AM EDT Reads: 8,307 |
By Elizabeth White In his session at Cloud Expo, Alan Winters, an entertainment executive/TV producer turned serial entrepreneur, will present a success story of an entrepreneur who has both suffered through and benefited from offshore development across multiple businesses: The smart choice, or how to select the right offshore development partner Warning signs, or how to minimize chances of making the wrong choice
Collaboration, or how to establish the most effective work processes
Budget control, or how to max... Mar. 30, 2017 12:45 AM EDT Reads: 664 |
By Liz McMillan Interoute has announced the integration of its Global Cloud Infrastructure platform with Rancher Labs' container management platform, Rancher. This approach enables enterprises to accelerate their digital transformation and infrastructure investments. Matthew Finnie, Interoute CTO commented "Enterprises developing and building apps in the cloud and those on a path to Digital Transformation need Digital ICT Infrastructure that allows them to build, test and deploy faster than ever before. The int... Mar. 30, 2017 12:30 AM EDT Reads: 1,526 |
By Pat Romanski China Unicom exhibit at the 19th International Cloud Expo, which took place at the Santa Clara Convention Center in Santa Clara, CA, in November 2016. China United Network Communications Group Co. Ltd ("China Unicom") was officially established in 2009 on the basis of the merger of former China Netcom and former China Unicom. China Unicom mainly operates a full range of telecommunications services including mobile broadband (GSM, WCDMA, LTE FDD, TD-LTE), fixed-line broadband, ICT, data communica... Mar. 30, 2017 12:15 AM EDT Reads: 3,573 |
By Pat Romanski ChatOps is an emerging topic that has led to the wide availability of integrations between group chat and various other tools/platforms. Currently, HipChat is an extremely powerful collaboration platform due to the various ChatOps integrations that are available. However, DevOps automation can involve orchestration and complex workflows. In his session at @DevOpsSummit at 20th Cloud Expo, Himanshu Chhetri, CTO at Addteq, will cover practical examples and use cases such as self-provisioning infra... Mar. 29, 2017 11:45 PM EDT Reads: 3,241 |
By Elizabeth White SYS-CON Events announced today that Ocean9will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Ocean9 provides cloud services for Backup, Disaster Recovery (DRaaS) and instant Innovation, and redefines enterprise infrastructure with its cloud native subscription offerings for mission critical SAP workloads. Mar. 29, 2017 09:30 PM EDT Reads: 2,459 |
By Pat Romanski MongoDB Atlas leverages VPC peering for AWS, a service that allows multiple VPC networks to interact. This includes VPCs that belong to other AWS account holders. By performing cross account VPC peering, users ensure networks that host and communicate their data are secure.
In his session at 20th Cloud Expo, Jay Gordon, a Developer Advocate at MongoDB, will explain how to properly architect your VPC using existing AWS tools and then peer with your MongoDB Atlas cluster. He'll discuss the secur... Mar. 29, 2017 07:30 PM EDT Reads: 923 |
By Elizabeth White Things are changing so quickly in IoT that it would take a wizard to predict which ecosystem will gain the most traction. In order for IoT to reach its potential, smart devices must be able to work together. Today, there are a slew of interoperability standards being promoted by big names to make this happen: HomeKit, Brillo and Alljoyn. In his session at @ThingsExpo, Adam Justice, vice president and general manager of Grid Connect, will review what happens when smart devices don't work togethe... Mar. 29, 2017 06:30 PM EDT Reads: 2,764 |
By Elizabeth White Building a cross-cloud operational model can be a daunting task. Per-cloud silos are not the answer, but neither is a fully generic abstraction plane that strips out capabilities unique to a particular provider. In his session at 20th Cloud Expo, Chris Wolf, VP & Chief Technology Officer, Global Field & Industry at VMware, will discuss how successful organizations approach cloud operations and management, with insights into where operations should be centralized and when it's best to decentraliz... Mar. 29, 2017 05:15 PM EDT Reads: 3,837 |
By Elizabeth White SYS-CON Events announced today that Juniper Networks (NYSE: JNPR), an industry leader in automated, scalable and secure networks, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY.
Juniper Networks challenges the status quo with products, solutions and services that transform the economics of networking. The company co-innovates with customers and partners to deliver automated, scalable and secure network... Mar. 29, 2017 04:30 PM EDT Reads: 1,710 |
By Elizabeth White Deep learning has been very successful in social sciences and specially areas where there is a lot of data. Trading is another field that can be viewed as social science with a lot of data. With the advent of Deep Learning and Big Data technologies for efficient computation, we are finally able to use the same methods in investment management as we would in face recognition or in making chat-bots. In his session at 20th Cloud Expo, Gaurav Chakravorty, co-founder and Head of Strategy Development ... Mar. 29, 2017 04:15 PM EDT Reads: 3,920 |
By Elizabeth White DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm. In his Day 3 Keynote at 20th Cloud Expo, Chris Brown, a Solutions Marketing Manager at Nutanix, will explore t... Mar. 29, 2017 04:00 PM EDT Reads: 3,249 |


text:
The authors have declared that no competing interests exist.
The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JW SL HW FY. Performed the experiments: JW SL EL YW CWa HZ DK. Analyzed the data: JW SL YL HW FY. Contributed reagents/materials/analysis tools: CWu HW FY. Wrote the paper: JW FY.
Pruning that selectively eliminates unnecessary axons/dendrites is crucial for sculpting the nervous system during development. During
Neurons have the ability to engage in selective pruning that eliminates unnecessary axons/dendrites. This process is crucial for sculpting the nervous system during development. During
The selective removal of unnecessary or exuberant neuronal processes without loss of neurons, referred to as pruning, is a central theme in the maturation of the nervous system during animal development
(A) A schematic representation of dendrite pruning in ddaC neurons. Soma and axon are shown in purple while dendrites are in black. (B–F′) Live confocal images of ddaC neurons expressing
(A) A schematic representation of axon pruning in the medial and dorsal lobes of MB γ neurons. (B–H) Confocal images of MB neurons expressing
The ubiquitin-proteasome system (UPS) is a potent cellular pathway regulating protein stability and homeostasis in eukaryotic cells
Here, we identified an E3 ubiquitin ligase complex that plays a crucial role in directing two distinct modes of pruning in ddaC and MB γ neurons during early metamorphosis. In a genome-wide RNA interference (RNAi) screen, we isolated Cullin1 (Cul1), a core scaffold protein of the SCF E3 ligase, which governs pruning of ddaC dendrites and MB axons. Additional components of the Cul1-based SCF E3 ligase include the RING domain protein Roc1a, the adaptor protein SkpA, and the F-box protein Slimb, all of which are essential for ddaC dendrite pruning and MB γ axon pruning. Cul1 acts together with Roc1a, SkpA, and Slimb to promote ddaC dendrite pruning downstream of EcR-B1 and Sox14, but independently of Mical. Furthermore, the Cul1-based SCF E3 ligase promotes ddaC dendrite pruning through negative regulation of the InR/PI3K/TOR signaling pathway but not its conventional target pathways, such as the Hedgehog (Hh) and Wingless (Wg) pathways
We previously reported high efficacy and specificity of inducible RNAi knockdown in ddaC neurons during the larval-pupal transition
To further verify the role of
Taken together, Cul1 is identified as the core component of the SCF E3 ligase that regulates pruning and apoptosis of sensory neurons during early metamorphosis.
We next attempted to identify other components of the Cul1-based SCF E3 ligase complex that are required for ddaC dendrite pruning. The Cullin proteins, via their C-terminal regions, bind to the RING-domain protein Roc1-Rbx1-Hrt1, which recruits an ubiquitin conjugating enzyme E2
(A–E′) Live confocal images of ddaC neurons expressing
Thus, Roc1a, like Cul1, plays an essential role in dendrite pruning of ddaC sensory neurons.
The N-terminal region of the Cullin proteins interacts with the adaptor subunit Skp1, and via it with an F-box protein to recruit protein substrates in proximity to the E2 enzyme, thereby promoting substrate ubiquitination
Given that the substrate specificity of the Cul1-based SCF E3 ligase complex is conferred by an F-box protein, we further performed a RNAi screen to examine the potential roles of 31 putative F-box proteins
Thus, SkpA and Slimb appear to play important roles in regulating ddaC/D/E dendrite pruning and ddaF apoptosis.
We next examined the potential requirements of Cul1, Roc1a, SkpA, and Slimb for MB axon pruning. In wild type, MB γ neurons selectively eliminated their larval axon branches by 24 h APF (
We next demonstrated the physical association among Cul1, Roc1a, SkpA, and Slimb. To this end, we first performed co-immunoprecipitation (co-IP) experiments in nontreated and ecdysone-treated S2 cells transfected with Myc-tagged Slimb. Endogenous unmodified Cul1 and Neddylated-Cul1 (Nedd8-Cul1
(A) Endogenous SkpA and Cul1 associated with Slimb in an ecdysone-independent manner. Nontreated (−) and ecdysone-treated S2 cells were transfected with Myc-Slimb. (B) Roc1a and Slimb associated in a complex with Cul1 and SkpA in S2 cells co-transfected with Myc-Slimb and Flag-Roc1a. (C) Endogenous SkpA and Cul1 co-immunoprecipitated with Myc-Slimb in the protein extracts from the wandering larval brains. (D) Expression profile of
To investigate whether the Cul1 SCF E3 ligase expression is upregulated during the larval-pupal transition, we utilized Laser Capture Microdissection (LCM) technique to microdissect MB γ neurons from wild-type,
(A–D) Confocal images show Mical stainings (in red) in various genotypes of ddaC neurons expressing
Taken together, Cul1, Roc1a, SkpA, and Slimb function as the components of the SCF E3 ligase complex, among which the expression of
Given that the EcR-B1/Sox14/Mical pathway governs ddaC dendrite pruning
Given that Mical expression is unaffected by the mutants of the SCF components, we hypothesized that the Cul1 SCF E3 complex might act in parallel with Mical during dendrite pruning. If this is true, we would expect enhancement of dendrite defects of
Taken together, our data suggest that the Cul1-based SCF E3 ligase complex acts downstream of EcR-B1/Sox14 and governs dendrite pruning in parallel with Mical.
During tissue growth and pattern formation, Cul1, Roc1a, and Slimb negatively regulate Hh or Wg pathways by specifically degrading their respective effectors, Ci or Armadillo
(A–H) Live confocal images of ddaC neurons expressing
To further investigate which signaling pathway might be attenuated by the Cul1-based SCF complex during ddaC pruning, we performed a candidate-based screen to systematically examine other important signaling pathways including Notch, Insulin, JNK, JAK/STAT, Hippo, EGFR, PVR, and Dpp. We expressed the dominant-negative repressors of these pathways, such as NotchDN, InRDN, BskDN, DomeΔCYT, YorkieS168A, EGFRDN, PVRDN, and TkvDN, in
To verify the specific effect of InR, we further conducted the genetic enhancement experiments in which InRCA or NotchCA, known to activate Insulin or Notch pathways, respectively, was expressed in
Collectively, these genetic suppression/enhancement results indicate that the Cul1-based SCF complex promotes ddaC dendrite pruning primarily through attenuation of the Insulin pathway.
InR functions through the PI3K/TOR signaling pathway to mediate protein translation, metabolism, and ribosome biogenesis
(A–J′) Live confocal images of ddaC neurons expressing
The PI3K pathway is interconnected with the Target of Rapamycin (TOR) pathway via TSC1 and TSC2, which act as negative regulators of the TOR pathway
The following lines of evidence indicate the specificity of these suppression effects. First, attenuation of the InR/PI3K/TOR pathway did not affect normal elaboration of major dendrites in
Taken together, the InR/PI3K/TOR pathway is specifically inhibited by the Cul1-based SCF E3 complex in order to promote ddaC dendrite pruning during early metamorphosis.
Since inactivation of the InR/PI3K/TOR pathway suppresses the dendrite pruning defects in ddaC neurons lacking the Cul1 E3 ligase activity, we next assessed whether compromised E3 ligase function causes hyperactivation of the InR/PI3K/TOR pathway. To this end, we examined the expression and activity of Akt, a positive regulator of the InR/PI3K/TOR pathway, in ddaC neurons and 6 h APF brain lysates. Using an anti-Akt antibody, a weak localization of endogenous Akt was detected in ddaC somas (
(A–C and E–F″) Confocal images show Akt stainings (in red) in various genotypes of ddaC neurons expressing
To further examine a potential link between the Cul1 SCF E3 ligase and the InR/PI3K/TOR pathway, we assessed the physical interaction between Akt and the F-box protein Slimb. The C-terminal region of Slimb contains seven WD40 domains that are responsible for binding to its substrates and targeting them for ubiquitination. Interestingly, Akt was co-immunoprecipitated with Slimb using the protein extracts of S2 cells co-transfected with Myc-Akt and Flag-Slimb (
We have demonstrated that inactivation of the InR/PI3K/TOR pathway by the Cul1-based SCF E3 ligase complex is required to facilitate ddaC dendrite pruning during early metamorphosis. To further substantiate it, we examined whether constitutive activation of the InR/PI3K/TOR pathway alone is sufficient to inhibit normal progression of ddaC dendrite pruning. Notably, the expression of InRCA, or PI3KCA, both known to constitutively activate the InR/PI3K pathway
(A–H) Live confocal images of ddaC neurons expressing
Similar to the Cul1 SCF E3 ligase, the InR/PI3K/TOR pathway regulates ddaC dendrite pruning in a Mical-independent manner. First, the protein levels of Mical, Sox14, or EcR-B1 were unaffected upon activation of the InR/PI3K/TOR pathway, via InRCA/PI3KCA expression or loss of
Local caspase activation in dendrites was shown to be required for elimination of dendrites in ddaC neurons
In summary, our data indicate that activation of the InR/PI3K/TOR pathway alone is sufficient to inhibit ddaC dendrite pruning in a Mical-independent manner. Thus, we demonstrate that during early metamorphosis, the Cul1-based SCF E3 ligase complex facilitates ddaC dendrite pruning primarily through inactivation of the InR/PI3K/TOR pathway.
Previous studies showed that the UPS activity plays an intrinsic and essential role in governing both modes of pruning in ddaC
Previous studies indicated that UPS activity is cell-autonomously required for both MB axon pruning and ddaC dendrite pruning in
Several lines of evidence indicate that the Cul1-based SCF E3 ligase complex is the specific one that governs both ddaC dendrite pruning and MB axon pruning. First, while Cul1 and its binding partner Roc1a are critical for pruning of ddaC and MB neurons, Cul3 and Roc1b that preferentially bind each other are not important. Second, the Cul4-based E3 ligase, which regulates TSC2 protein stability and TSC1/2 complex turnover in
We previously reported that a transcriptional hierarchy, consisting of EcR-B1, Sox14, and Mical, is commonly induced in both ddaC neurons and MB γ neurons, and essential for ddaC dendrite pruning
During pattern formation, the Cul1-based SCF E3 ligase degrades Ci or Arm to negatively regulate Hh or Wg pathways, respectively
It has been reported that ecdysone can inhibit the release of insulin-like peptides from insulin-producing-cells during the larval-pupal transition, systemically inactivate the InR/PI3K/TOR pathway, and thereby terminate larval growth
In summary, we demonstrate that the Cul1-based SCF E3 ligase plays crucial roles in directing two distinct modes of pruning in ddaC and MB γ neurons in
The following fly stocks were used in this study:
The following stocks were obtained from Bloomington stock centre (BSC):
The following Stocks were obtained from Vienna Drosophila RNAi Centre (VDRC):
The GATEWAY pTW vector containing a fragment of the
The cDNA fragment corresponding to the last 359 aa of Mical was amplified by PCR and verified by DNA sequencing. The product was expressed using the GST expression vector (pGEX 4T-1, Pharmacia) and the purified protein was used to immunize guinea pigs to generate antibodies against Mical. The specificity of the guinea pig anti-Mical antibody was verified using
We carried out MARCM analysis, dendrite imaging, and quantification as previously described
Larval and pupal fillet samples for each set of experiments were processed simultaneously, stained in the same tube, and imaged with the same parameters using Leica SPE confocal microscope. The following antibodies were used for immunohistochemistry at the indicated dilution: guinea pig Anti-Mical (1∶500), mouse polyclonal anti-Sox14 (1∶200), mouse anti-EcR-B1 (1∶50, DDA2.7, DSHB), rabbit anti-GFP (1∶1000, A11122, Invitrogen), mouse anti-FasII (1∶100; 1D4, DSHB), rabbit anti-Akt (1∶500, #4691L, Cell Signaling), and rabbit anti-cleaved PARP (1∶500, 2317-50, Abcam). Cy3- and Cy5-conjugated secondary antibodies (Jackson Laboratories) were used at 1∶400 dilution.
We carried out S2 cell culture, ecdysone treatment, and Western blotting as described
Transfected S2 cells or prepupae brains were homogenized with lysis buffer (25 mM Tris pH8/27.5 mM NaCl/20 mM KCl/25 mM sucrose/10 mM EDTA/10 mM EGTA/1 mM DTT/10% (v/v) glycerol/0.5% Nonidet P40) with protease inhibitors (Complete, Boehringer; PMSF 10 µg/ml, Sodium orthovanadate 10 µg/ml) in presence or absence of ecdysone (20E). The supernatants were used for immunoprecipitation with anti-Myc, anti-Flag, or anti-Akt overnight at 4°C, followed by incubation with protein A/G beads (Pierce Chemical Co.) for 2 h. Protein A/G beads were washed four times with cold PBS. Bound proteins were separated by SDS-PAGE and analysed by Western blotting with anti-Myc, anti-Flag, anti-Cullin-1, anti-SkpA, and anti-Akt.
S2 cells were transfected with Flag-Slimb, Flag-SlimbΔWD40, Myc-Akt, and pHsp70-hemagglutinin (HA)-ubiquitin (A.Sehgal). At 48 h postransfection, cells were homogenized with the lysis buffer (25 mM Tris pH8/27.5 mM NaCl/20 mM KCl/25 mM sucrose/10 mM EDTA/10 mM EGTA/1 mM DTT/10% (v/v) glycerol/0.5% Nonidet P40) with protease inhibitors (Complete, Boehringer; PMSF 10 µg/ml, Sodium orthovanadate 10 µg/ml). The supernatants were used for immunoprecipitation with anti-Myc, overnight at 4°C, followed by incubation with protein A/G beads (Pierce Chemical Co.) for 2 h. Protein A/G beads were washed four times with cold PBS. Bound proteins were separated by SDS-PAGE and analysed by Western blotting with anti-Myc, anti-HA, and anti-Flag.
Live confocal images of ddaC neurons expressing
Larval, pupal, and adult brains were dissected in PBS and fixed in 4% formaldehyde for 15 min. Brains were washed in PBS+1%Triton X for 3 times for 10 min each. For the clonal analysis study (MARCM), embryos were collected at 6 h interval. The clones were induced in the first instar lavae by applying a 1 h heat shock at 38°C. The antibody to FASII (1D4) was obtained from the Developmental Studies Hybridoma Bank and used at 1∶50. Rabbit anti-GFP antibody was obtained from Invitrogen and used at 1∶1,000.
To quantify the immunolabeling intensities, cell nuclei (EcR-B1/Sox14 immunostaining) or whole cell body (Mical immunostaining) were drawn on the appropriate fluorescent channel based on the GFP channel relative cellular localization in ImageJ software. After subtracting the background (Rolling Ball Radius = 30) on the entire image of that channel, we measured the mean grey value in the marked areas in ddaC and ddaE on the same images and calculated their ratios. The ratios were normalized to corresponding average control values and subjected to statistical
To quantify the immunolabeling intensities of Akt, soma/dendrite/axon regions were drawn on the appropriate fluorescent channel based on the GFP channel relative cellular localization in ImageJ software. After subtracting the background, we measured the mean grey value of Akt in the marked areas. The values were normalized to corresponding average control values and subjected to statistical
To avoid any developmental delay, wild-type or mutant embryos were collected at 6 h intervals and were reared on standard food to the 3rd instar stage (96 h after egg laying, AEL) before being transferred to the standard culture medium containing 2 µM of Rapamycin dissolved in ethanol (Sigma Aldrich R0395). Larvae were fed in Rapamycin food for approximately 8 h before cessation of feeding. The onset of puparium formation and adult eclosion was not affected by Rapamycin treatment. wL3 larvae were used to quantify the total dendrite termini.
To avoid any developmental delay, wild-type or mutant embryos were collected at 6 h intervals and were reared on standard food to the e3L stage before being transferred to the standard culture medium containing 240 µg/ml mifepristone dissolved in ethanol (Sigma Aldrich M8046). The onset of puparium formation and adult eclosion was not affected by RU486 treatment.
Isolation of RNA from MB γ neurons was accomplished using Laser Capture Microdissection (LCM). Ten-micrometer frozen sections were cut from larval or pupal brains. MB γ neurons labeled by
Independent experiments were conducted in triplicates using Maxima SYBR Green/ROX qPCR Master Mix (Fermentas) and 7900HT Fast Real-time PCR system (Applied Biosystems) according to the manufacturer's recommendations.
We thank S. Artavanis-Tsakonas, K. Basler, C.T. Chien, S. Cohen, R.J. Duronio, E. Hafen, I. Hariharan, J. Castelli-Gair Hombria, Y.N. Jan, J. Jiang, A.L. Kolodkin, B. Limbourg-Bouchon, L. Luo, T. Murphy, M. O'Connor, N. Perrimon, P. Rorth, T. Uemura, D.W. Williams, C. Wilson, T. Xu, the Bloomington Stock Center (BSC), DSHB (University of Iowa), and VDRC (Austria) for generously providing antibodies and fly stocks. We thank members of the Yu laboratory for helpful discussions.
eukaryotic translation initiation factor 4E binding protein
after puparium formation
central nervous system
dorsal dendrite arborization
dominant negative form
Ecdysone Receptor
early 3rd instar
Insulin Receptor
Laser Capture Microdissection
mushroom body
peripheral nervous system
the Phosphatase and tensin homologue
Quantitative real-time PCR
Ras homologue enriched in brain
RNA interference
p70 ribosomal protein S6 kinase
Supernumerary limbs
Target of Rapamycin
ubiquitin-proteasome system
wandering 3rd instar
white prepupal


text:
? Re Adcom GFA 555ii
I'm considering replacing the 4 large caps in my Adcom 555ii amp with Nichicon gold tune caps. My ?'s are:
Does the large power supply caps influence sound? How long do these large caps last? One of the large original caps is starting to leak and I have already added the bypass caps and replaced all other existing caps with Elna Cerafines. Thanks |
See the image at: http://www.diyaudio.com/forums/power...ml#post3117390 |
All times are GMT. The time now is 10:56 AM. |
vBulletin Optimisation provided by
vB Optimise (Pro) -
vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.
Copyright ©1999-2017 diyAudio


text:
- Hi there, welcome to Tribesmart. Log in to get started...
Canon Eos 7d Digital Slr Camera, Body Only
Guide price: £1030
Last updated on 22nd Nov 2013
Tags: electricals photography camcorders digit
Canon Eos 7d Digital Slr Camera, Body Only
An ideal choice for the passionate photographer, the Canon EOS 7D is packed with advanced features including an 18 megapixel resolution, a 100% viewfinder, and Full HD 1080 video recording. 18 megapixels allows incredible choice and flexibility when it comes to cropping your images. And the 100% coverage viewfinder provides the most complete and natural view of your subject. It also has a Dual Axis Electronic Level to ensure perfect horizons.
The 7D is perfect for shooting in low light thanks to ISO speeds of up to 6400. It's also expandable to ISO 12800, for low light scenes where using flash is undesirable. It also features Canon's powerful DIGIC 4 processing engine which delivers smooth gradations and more natural looking colours. The wide area focusing system uses 19 individual points allowing you to focus with greater precision on off-centre subjects.
It's also a great choice for sports, wildlife and action sequences, as it can capture 8 frames per second for continuous bursts of up to 126 JPEGs. You'll also be able to shoot video in Full HD 1080, ready for playback on your high definition TV. Viewing your images and video is a joy with the 3-inch LCD screen.
It also features Live View mode also gives you the option of framing your image from the LCD, which comes in handy when you're shooting from an awkward position. All this advanced technology is packed into a durable magnesium alloy body with weather sealing. And to maintain the highest possible quality of image, the 7D features a cleaning system to keep the sensor clean.
Feeling creative? One of the biggest advantages of SLR digital cameras is the sheer shooting flexibility they offer. You can use various additional lenses to take wide-angle, telephoto, or close-up shots, to shoot a wide variety of subjects. The shorter the focal length (measured in mm), the wider the view will be – the longer the focal length, the more telescopic the picture.
With a selection of interchangeable lenses at your disposal, the creative possibilities are endless. Why not take a look at our range of additional SLR lenses? Note: Please check the compatibility of the lens with your camera.
Login or Register to add this to your wish list or favourites.
Similar to Canon Eos 7d Digital Slr Camera, Body Only
Clip On 7" Full HD 1280P Color LCD TFT Monitor for DSLR
This is a portable LCD monitor for use with an interchangeable lens digital camera or an interchangeable Lens digital HD video camera recorder with and HDMI terminal and live view mode. It can display HDMI video output from the camera. Helping photo enthusiasts and video-graphers shoot high-quality HD video footage with their interchangeable lens digital camera. To know more visit https://www.zapals.com/cameras-accessories/inspection-cameras.html


text:
Reasons We Believe Pb Paperback
50 Lines of Evidence That Confirm the Christian Faith
by Nathan Busenitz;
Stock available
Free UK delivery when you spend £10 or more
If you're buying for a church, school or business, why not Buy Now Pay Later?
Find Out MoreReasons We Believe Pb
Full Product Description
Will strengthen your personal faith by demonstrating the reliability of both the Word of God and the person of Jesus Christ. Provides clear, concise, evangelistic tools to help you share that faith with others.
Reasons We Believe Pb by Nathan Busenitz was published by Crossway in July 2008 and is our 58275th best seller. The ISBN for Reasons We Believe Pb is 9781433501463.
Reviews of Reasons We Believe Pb
Customer reviews and testimonials Write a review
Details for Reasons We Believe Pb
Page last updated | 20th May 2016 |
Author / Artist | Nathan Busenitz |
Book Format | Paperback / softback |
Publisher | Crossway (July 2008) |
Weight | 279g |
Number of Pages | 224 |
Thickness | 15 mm |
Height | 216 mm |
Width | 140 mm |
Product Code | 1235488 |


text:
Click Here to Login |
Register | Cooking Links | Member Photos | FAQ | Members List | Social Groups | Calendar | Search | Today's Posts | Mark Forums Read | Log in |
MD - Solomans and Snow Hill ... our Chesapeak Bay road trip
ENGLAND - London ... any new ideas?
Our communities encompass many different hobbies and interests, but each one is built on friendly, intelligent membership.
» More about our Communities
Our Automotive communities encompass many different makes and models. From U.S. domestics to European Saloons.
» More about our Automotive Communities
Our Marine websites focus on Cruising and Sailing Vessels, including forums and the largest cruising Wiki project on the web today.
» More about our Marine Communities


text:
Shallow Groundwater Collection for Reuse in Irrigation
by G. G. Mahin, Univ of Nevada, Reno, United States,J. C. Guitjens, Univ of Nevada, Reno, United States,
Document Type: Proceeding Paper
Part of: Irrigation and Drainage
Abstract: A prototype system of subsurface drains for collection of shallow groundwater and reuse of drainage water for reuse in irrigation was examined. The system involved a field with subsurface drains, a reservoir for storing drainage water, and conveyance facilities for irrigation with drainage water. Benefits of recycling include the reduction in demand for fresh water, improvement of drainage within an irrigation project, and reduction of pollutant discharge into wetlands.
Subject Headings: Drainage systems | Irrigation systems | Subsurface drainage | Groundwater | Water resources | Water storage
Services: Buy this book/Buy this article
Return to search


text:
"Why did you choose this product?"
Add the finishing touch to your home decor with chair cushion from Pillow Perfect. A lovely blue and green pattern highlight this cushion.- Set includes: One (1) chair cushion
- Pattern: Mardin
- Color: Blue/green
- Cover closure: Sewn seam
- Edging: Knife edge
- Pillow shape: Square
- Dimensions: 19 inches wide x 19 inches long
- Cover: 100-percent cotton
- Fill: 100-percent polyester
- Care instructions: Spot clean only
The digital images we display have the most accurate color possible. However, due to differences in computer monitors, we cannot be responsible for variations in color between the actual product and your screen.
Please note:This item is made to order and each pattern may be cut differently. If buying two of the same item, minor differences in size or pattern should be expected. Note: Color discrepancies may occur between this product and your computer screen.
Features | |
Style | Casual, Patterned |
Material | Cotton |
Type | Chaise, Tufted |
Pattern | Geometric |
Set Size | Single |
Shape | Square |
Color | Blue |
Dimensions | 19 in. L X 19 in. W X 5 in. D |
Model Number | 473987 |
Country of Origin | United States |
Similar Items
16x16 Memory Foam Chair Pad/Seat Cushion with Non-Slip Backing (2 or 4 Pack)
Today: $28.99 - $54.99
Blazing Needles 16-inch U-Shaped Twill Dining Chair Cushions (Set of 4)
Today: $54.57 - $69.99
Windsor Home Memory Foam Chair Pad - Set of 2
Today: $24.69
Blazing Needles 16x16-inch Round Twill Chair Cushions (Set of 2)
Today: $38.11 - $41.49
Blazing Needles 16-inch U-shaped Tufted Twill Dining Chair Cushions (Set of 4)
Today: $54.49 - $69.49
Blazing Needles Microsuede Tufted 48-inch Swivel Rocker Cushion
Today: $59.49 - $75.42
Blazing Needles Twill Swivel Rocker Cushion
Today: $56.43 - $66.49
Pillow Perfect Acela Adobe Reversible Chair Pad (Set of 2)
Today: $62.85
Product Reviews
Questions & Answers
need to add height to an existing chair
"How do these stay on? Do they tie or velcro?"
Thank you for contacting us yogimags. These pillows have ties in the back. Please let us know if you have any further questions.
"does this cushion have ties to the chair?"
Hello, yes this does have ties.
Shopping Tips & Inspiration
How to Choose Dining Chair Cushions
If you have uncomfortable chairs in your kitchen or dining room, this handy guide can help you find a chair cushion that works for you.
Kitchen Decor Ideas
Kitchen Decor Ideas from Overstock.com. Our guides provide customers with kitchen decor ideas.
Kitchen Decor Buying Guide
Kitchen Decor Buying Guide from Overstock.com. Our guides provide customers with information about kitchen decor.
How to Decorate with a Monochromatic Color Scheme
With a simple color palette leading the way, monochromatic design lets you get creative with textures, designs, and contrast. Take a look at three different rooms where we let one color take the wheel and show you how to create a monochromatic design in your own home.
Top 3 Must-Have Kitchen Gadgets Under 50
Every home cook has an arsenal of kitchen gear they rely on to prepare great meals. As an avid home cook myself, I like experimenting with new recipes and getting creative with my favorite cooking tools. Multipurpose kitchen gadgets will always give you the biggest bang for your buck.
How to Care for Nonstick Cookware
Nonstick cookware is an asset in the kitchen for many reasons. Follow our handy tips to give your nonstick pots and pans the care they deserve.
When to Replace Household Items
With our busy lives, there are little things that often get overlooked, like keeping track of how long we've used our pillows or bath towels. However, replacing these things in a timely fashion is efficient and helpful in having a smoothly run household.
Top 10 Christmas Gift Ideas for the Home Chef
If you have a passionate home cook on your shopping list, you're looking for the perfect kitchen gadget gift. We've made finding that gift easy-peasy with this list of top kitchen tools.
Top 10 Christmas Gift Ideas for the Hostess
Treat the entertainer on your Christmas list to a thoughtful gift that shows your appreciation. Hostesses exemplify hospitality, so look for gifts that will add to her repertoire of party ware. If she already has a fully stocked arsenal of party gear, consider a personalized item or gourmet gift basket. For more shopping inspiration, read on to see our list of top holiday gift ideas for the hostess.
Stocking Stuffers for the Home Chef
If you have foodie friends who constantly ask you to "taste this" or "sniff that," a Christmas stocking loaded with kitchen gear will certainly make his or her holiday sweeter. Give the gift that ultimately gives back with cooking essentials that will have any home chef racing to the kitchen to whip up a new creation. If you're looking for the best stocking stuffers for the home chef, check out our list of stocking-sized picks.
Urban Farmhouse Kitchen
Evoke a sense of warmth and comfort combined with decorative elements in this jesGORDON farmhouse kitchen.
- |
Shipping & Returns
Contact Information
Shipping Information:
Our standard shipping method is ground shipping. We also offer expedited shipping for most items. Your final
shipping cost and estimated delivery timeframe will be available at checkout.
Standard shipping details
Expedited shipping details
Standard Return Policy:
Items must be returned in new or unused condition and contain all original materials included with the shipment. More Details
FINAL SALE EXCLUSION: Items marked as FINAL SALE are not returnable unless the problem you experience is the result of our error.
For your protection, all orders are screened for security purposes. If your order is selected for review, our Loss Prevention Team may contact you by phone or email. There may be a two business day delay to process your order.
** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.


text:
If you have been a constant reader of our recent ATI Radeon X1800 XT 512MB articles, you should know the ins and outs of ATI's best graphics card by now. The clock speeds, the noisy, two-slot cooler, the power requirements. You should also know that almost every other vendor has been going strictly by the design book as authored by ATI with ASUS being the only one thus far to have bucked the trend. MSI is the next manufacturer that has sent us its version of the Radeon X1800 XT 512MB, the RX1800XT-VT2D512E and predictably, we were greeted by the obnoxious whine of its standard cooler. The MSI RX1800XT-VT2D512E keeps to the conservative clock speeds dictated and before we go into its details, here are its technical specifications:
Find a new home for humanity. The journey begins now. How far will you go?
5 things to consider when you buy home broadband plans


text:
I know this is the crappiest... | [ Sizes: Orig | Med | Small | Thumb ] | |||
I know this is the crappiest of pictures, but i just wanted to post it because it shows the view of Nevado from the south side in such a way that both the west and east summits are visible. This picture is taken through tinted bus windows on highway 54. | Image Data
Image ID: 93312 Hits: 1357 Lat/Lon: 19.33000°N / 103.38°W Object Title: I know this is the crappiest... |


text:
Week in Biking : Track Bikes, Tax Benefits and Hot Dropouts
We're not talking about college dropouts, here; this is about that special place where your rear wheel gets to connect with your frame. While there really isn't much left to reinvent on the bicycle, dropout systems that add ease and versatility are a welcome development, including these new designs:
- The new All-City Nature Boy Disc dropout, which features a sliding caliper design that with an integrated chain tensioner for perfect caliper to rotor alignment every time.
- And Surly wants to help you achieve your dream on One Bike to Rule Them All with its new Modular Dropout System.
Now while versatility is cool, some would argue that nothing beats the pure pleasure of riding track bikes–as the market would attest.
- Among the latest are the Keirin and Keirin Pro frames from Pure Fix. With stainless steel inserts in the drops (drops on drops on drops), and optional integrated headset and seatclamp, these frames pack a lot of potential for a small chunk of change–$199 and $299, respectively.
- Something sexy is underway from Stanridge Cycles: A collaboration with artist Ben EINE for the 2014 Red Hook Crit. Get a sneak peak here.
Whatever kind of bike(s) you ride, if you're riding to work, you could be cashing in on the bicycle commuter reimbursement. Find out more about how you can put pre-tax cash in your pocket for commuting by bike.
"Riding in Mumbai is a mess." Find out why Nikhil Miranda loves riding in the city.


text:
Reflection: Organizational Systems Designing an Eco-friendly Building Part 2 - Section 1: Design Solutions
Sharing takes on a different role in engineering. Collaboration is the key to finding the best idea. If someone says that they can get rid of a natural gas furnace and put in a geo-thermal system, everyone benefits. In engineering, designs can be mutually beneficial. I teach the difference between collaboration and cheating in my movie Cheating vs. Collaboration.
Diversity becomes important when sharing. I ask students, "Do you think the ideas between you and your best friend will be the same or different?" Students almost always say, "The same!" I challenge them to find someone who thinks differently. "Why do you think its important to share with someone NOT like you?" Students understand that the design solutions may be different because of the diversity.
Designing an Eco-friendly Building Part 2
Lesson 2 of 10
Objective: SWBAT create solutions for the design problem: How do we design an eco-friendly home?
Big Idea: What do we know about eco-friendly building? This lesson allows students to research eco-friendly components as students determine the best solution an authentic design problem.
Design Solutions
Students have completed Designing an Eco Friendly Home Part 1 and are now ready to start to design. My strategy is to use conceptual models to promote understanding. Using pencils, students draw a preliminary design of what they think the home should look like. I ask them to consider the rooms, dimensions and the layout of the building. They become frustrated because they need more information. My intention is for them to want to do some research to design the best solution.
My students are at tables of four. After they have finished drawing their models, they share models with the students at their tables. This helps alleviate the frustration of not knowing what to do. There are lots of teaching strategies for sharing work but in STEM classes, there is also a component of collaboration. The strategy I use is Give One-Get One. Students write down one sentence about why they drew their preliminary design the way they did. I number off all students in pairs. I say, "Give One Get One." Students go to their partners to give and get an idea.
Resources (1)
Resources (1)
Research Questions
After the preliminary drawings, I ask students to think about what they need to know in order to design an eco-friendly home. I use a think-pair-share strategy for the next part of the lesson. My intention is to give students think time as well as partner discussion time.
By themselves, students write down questions they have regarding eco-friendly design. I ask them to consider the size of the building and the dimensions of the rooms. Then they pick a shoulder partner and share questions. Finally they share with the entire table. Students write down one another's questions in their notebooks. One person goes to the computer and shares a Google Document of their questions with me. I make a new document in Google Docs called Eco Friendly Home Questions by cutting and pasting the student questions in the document. We examine the questions as a class, deleting questions that repeat and re-wording questions.
At this point I become an expert. I say, "There are some science principles you will need to know to design the best solution." I ask my students to write down, "What is geo-thermal heating? What is passive solar heating?" My intention is to build in questions that connect content standards to learning.
Conducting Research
At this point the students have questions to research. I pair them up into research partners. Partners divvy up the questions so they are sharing the responsibility for completing the research. I ask students, "Why do you think I do this?" Their responses include, "We want to get correct answers." "We want to have more than one site as a reference.
A research strategy I use is called Creating a Reference. This strategy allows students to cut and paste research answers into a document. Many of the research questions are student generated and may or may not be useful in the project. My intention for this activity is for students to create a reference sheet that can be used later to defend designs. For example, a child may find the answer to an eco-friendly material is recycled insulation. No one knows if this information is useful until the child's concept of the design has progressed.
Take a look at the Student Sample in the movie below.
The purpose of the Reference sheet is to find answers and record URLs for use later in the lesson so I want them to cut and paste. They will be summarizing and using citations as they defend their design and this reference sheet prevents having to find sites all over again. In addition, because students have been to the sites, it is easy to go back and find useful information from a site they already looked at.
Similar Lessons
Environment: Urban
Electromagnetic Spectrum: How Does it Affect Our Lives?
Environment: Suburban
Design Your Own Simple Machine
Environment: Urban
- UNIT 1: Exploring Engineers and the Design Process
- UNIT 2: Generating Energy
- UNIT 3: Energy Sources
- UNIT 4: Measuring Energy
- UNIT 5: Exploring Non-Renewable Energy Sources
- UNIT 6: Designing for the Future: Eco Friendly Building
- UNIT 7: Designing for the Future: Wind Turbine Design
- UNIT 8: Designing for the Future: Nuclear Waste Facility
- UNIT 9: Designing for the Future: Designing a Solar Car
- LESSON 1: Designing an Eco-friendly Building Part 1
- LESSON 2: Designing an Eco-friendly Building Part 2
- LESSON 3: Designing an Eco-friendly Building Part 3
- LESSON 4: Designing An Eco-friendly Building Part 4
- LESSON 5: Heat Transfer in Architecture
- LESSON 6: Heat Transfer in Architecture: Convection
- LESSON 7: Heat Transfer in Architecture: Conduction
- LESSON 8: Heat Transfer in Architecture: Radiation
- LESSON 9: Eco-friendly Construction Materials
- LESSON 10: Integrating Technology: Using Autodesk Revit


text:
Synopsis Canadean's "Packages Limited : Packaging - Company Profile, SWOT and Financial Analysis" contains in depth information and data about the company and its operations. The profile contains a company overview, key facts, major products and services, SWOT analysis, business description, company history, key competitors, financial analysis, mergers and acquisitions, recent developments, key employees as well as company locations and subsidiaries. Summary This report is a crucial resource for industry executives and anyone looking to access key information about "Packages Limited" The report utilizes a wide range of primary and secondary sources, which are analyzed and presented in a consistent and easily accessible format. Canadean strictly follows a standardized research methodology to ensure high levels of data quality and these characteristics guarantee a unique report. Scope - Examines and identifies key information and issues about "Packages Limited" for business intelligence requirements. - Studies and presents the company's strengths, weaknesses, opportunities (growth potential) and threats (competition). Strategic and operational business information is objectively reported. - The profile also contains information on business operations, company history, major products and services, key employees, and locations and subsidiaries. Reasons To Buy - Quickly enhance your understanding of "Packages Limited" - Gain insight into the marketplace and a better understanding of internal and external factors which could impact the industry. - Increase business/sales activities by understanding your competitors' businesses better. - Recognize potential partnerships and suppliers. Key Highlights Packages Limited (Packages) is a provider of packaging and consumer products. It offers a comprehensive range of packaging solutions such as folding cartons, flexible packaging materials, and consumer products such as tissue products. The company also produces and commercializes finished and semi finished inks. Its products are utilized in several industries including food and beverages, pharmaceuticals, electronics, tobacco, pesticide, tea, shampoo, confectionery, diary products and textile industries. Its distributes its products across the Middle East, Sri Lanka and Africa. Packages Limited is headquartered in Lahore, Pakistan.
Table Of Contents1 Packages Limited
2 Packages Limited - Key Employees
3 Packages Limited - Key Employees Biographies
4 Packages Limited - Major Products and Services
5 Packages Limited - History
6 Packages Limited - Company Statement
7 Packages Limited - Locations and Subsidiaries
7.1 Packages Limited - Head Office
7.2 Packages Limited - Other Locations and Subsidiaries
8 Packages Limited - Business Analysis
8.1 Packages Limited - Company Overview
8.2 Packages Limited - Business Description
9 Packages Limited - SWOT Analysis
9.1 Packages Limited - SWOT Analysis - Overview
9.2 Packages Limited - Strengths
9.2.1 Strength - Broad Product Portfolio
9.2.2 Strength - Focus on Research and Development
9.2.3 Strength - Global Business Alliances
9.2.4 Strength - Improved Efficiency Ratios
9.3 Packages Limited - Weaknesses
9.3.1 Weakness - Weaker Liquidity Position
9.4 Packages Limited - Opportunities
9.4.1 Opportunity - Growing Global Packaging Industry
9.4.2 Opportunity - Business Expansion
9.4.3 Opportunity - Global Economic Outlook
9.5 Packages Limited - Threats
9.5.1 Threat - Intense Competition
9.5.2 Threat - Price Fluctuations of Raw Materials
9.5.3 Threat - Stringent Environmental Regulations
10 Packages Limited - Company Financial Analysis
10.1 Packages Limited - Five Year Snapshot: Overview of Financial and Operational Performance Indicators
11 Packages Limited - Interim ratios
11.1.1 Packages Limited - Financial ratios: Capital Market Ratios
11.2 Packages Limited - Financial Performance and Ratio Charts
11.2.1 Packages Limited - Revenue and Operating margin
11.2.2 Packages Limited - Asset and Liabilities
11.2.3 Packages Limited - Net Debt vs. Gearing Ratio
11.2.4 Packages Limited - Operational Efficiency
11.2.5 Packages Limited - Solvency
11.2.6 Packages Limited - Valuation
11.3 Packages Limited - Key Competitors
12 Packages Limited - Mergers and Acquisitions and Partnerships
12.1 Packages Limited - MandA and Partnerships Strategy
13 Packages Limited - Recent Developments
14 Appendix
14.1 Methodology
14.2 Packages Limited - Ratio Definitions
14.3 DisclaimerList Of TablesTable 1: Packages Limited - Key Employees
Table 2: Packages Limited - Key Employees Biographies
Table 3: Packages Limited - Major Products and Services
Table 4: Packages Limited - History
Table 5: Packages Limited - Subsidiaries
Table 6: Packages Limited - Locations
Table 7: Packages Limited - Annual ratios
Table 8: Packages Limited - Interim ratios
Table 9: Packages Limited - Capital Market RatiosList Of FiguresFigure 1: Packages Limited - Revenue and Operating Profit
Figure 2: Packages Limited - Financial Position
Figure 3: Packages Limited - Net Debt vs. Gearing Ratio
Figure 4: Packages Limited - Operational Efficiency
Figure 5: Packages Limited - Solvency
Figure 6: Packages Limited - Valuation


text:
"The most terrible thing about materialism, even more terrible than its proneness to violence, is its boredom, from which sex, alcohol, drugs, all devices for putting out the accusing light of reason and suppressing the unrealizable aspirations of love, offer a prospect of deliverance."
Malcolm Muggeridge
"Jump out the window if you are the object of passion. Flee it if you feel it. Passion goes, boredom remains."
Coco Chanel
"Uncertainty and mystery are energies of life. Don't let them scare you unduly, for they keep boredom at bay and spark creativity."
R. I. Fitzhenry
"There's no excuse to be bored. Sad, yes. Angry, yes. Depressed, yes. Crazy, yes. But there's no excuse for boredom, ever."
Viggo Mortensen
"Work spares us from three evils: boredom, vice, and need"
"God created woman. And boredom did indeed cease from that moment -- but many other things ceased as well!"
Friedrich Nietzsche
"A subject for a great poet would be God's boredom after the seventh day of creation."


text:
Show your shape in the Tredstep™ Curved Snaffle Belt. This unique ladies' belt exhibits Tredstep Ireland's expertise in combining beautiful lines, tradition and premium materials. It complements the tailoring of the signature Definition Waistband established in the top-selling Symphony breech collection, creating a flattering silhouette highlighted by luxurious leather and striking detailing.
Order the same size as your breech size.
Premier product - this product is not eligible for any discounts off the purchase price.
Dover Saddlery is proud to offer a 100% satisfaction guarantee on all of our products. We stand behind the quality of our products, and should you not be satisfied with your purchase, simply return it and we will refund, replace or exchange it for you.
100% Satisfaction Guaranteed - Your Money Back Any Time, for Any Reason.
Dover Saddlery understands your concerns regarding online security. We share in your concerns and therefore work hard with experts in the field to maintain a highly secure ordering environment. Along with our comment to security, we offer you a Secure Order Guarantee - this gives you 100% protection for your credit card transactions on Doversaddlery.com.
Our Secure Order Guarantee means that you will never have to pay any money related to unauthorized charges to your credit card account, as long as those charges are a direct result from a transaction on Doversaddlery.com.
How it works: If you experience credit card fraud, the Fair Credit Act specifies that your credit card company can hold you liable for no more than $50.00 in fraudulent charges to your account. Our Secure Order Guarantee will reimburse you for any amount up to $50.00 billed to you by your credit card company for unauthorized charges to your account, if those charges result from an order you placed with Doversaddlery.com. For this protection you must promptly notify your credit card company of fraudulent charges and follow their procedures as outlined in your credit card agreement.
Show us your equestrian style. #itsfromdover


text:
'You know what to do'… we all do, we just need to access the power and wisdom within ourselves.
Beneath every negative feeling, there are always profound feelings of love, joy and peace. Sometimes, the most precious jewels are found within the depths of darkness. Shine a light on the darkness and it disappears. The joy and beauty within are truly blissful.
- Simple and effective techniques
- Reprogram limiting subconscious thoughts and beliefs
- Address core issues to effectively transform your life and wellbeing
- Enhance relationships, work, finances, fun, vitality, feelings of peace and connection
Dianne is an Advanced Psych-K facilitator and Breathwork practitioner, author, radio presenter, keen surfer, photographer and filmmaker. Having overcome serious and chronic ill-health, including Lyme disease and a serious cancer scare, Dianne passionately shares the most simple and gentle techniques she has found to effectively and powerfully enhance physical and emotional wellbeing. Read more here – About Dianne
To release physical or emotional stress, enhance your relationships, improve sporting performance or life in general, go to PSYCH-K® session page
Photo by: Dianne Ellis


text:
AUGUSTA – Gov. Paul LePage on Thursday vetoed a bill that could lead to the creation of a state-run virtual school, just hours after its final passage in the Senate.
The Senate voted 24-11 to support L.D. 1736, a bill that would create a group to evaluate the costs and formation of a state-run virtual school, while imposing a one-year moratorium on the licensing of private virtual charter schools. Four Republicans supported the bill, which is sponsored by Sen. Brian Langley, R-Ellsworth.
The House previously supported the bill on a 94-51 vote, with mostly Democrats voting in favor. That's not enough of a margin to override the governor's veto. The governor and other Republicans object to the moratorium provision.
In his veto message, LePage said a moratorium hurts private virtual charter schools and does nothing to help advance the development of a state-run school.
"It merely denies hundreds of children who need … access to their best educational opportunity," he wrote.
Rep. Brian Hubbell, D-Bar Harbor, a co-sponsor of the bill, said in a statement that he appreciated that LePage acknowledged the benefits of a state-run virtual school, but said the veto "means that limited public resources would be funneled toward a small number of students in a virtual school environment that has not yet been proven in Maine."
He added, "It is our responsibility as a state to ensure that public education dollars are spent as effectively as possible to the benefit of all Maine students."
Students in virtual schools learn largely from home, getting lessons online and having limited face-to-face interaction with teachers and administrators. Supporters say the schools are good for students who struggle in traditional schools, from top athletes in intense training to students who have been bullied.
Proponents say a state-run virtual school would provide the same benefits while avoiding some of the problems that have plagued some private virtual charter schools. Some have been criticized for outsourcing their management to for-profit companies that are beholden to shareholders.
The moratorium provision in L.D. 1736 would directly affect Maine Connections Academy, which on Monday received approval by the Maine Charter Commission to become the state's first virtual charter school. Maine Connections Academy plans to open this fall.
The school has contracted with Connections Learning of Baltimore, a company that operates virtual schools in 23 states. The school's board chairwoman is Amy Volk, a Republican state representative from Scarborough who co-sponsored the bill in 2011 that created charter schools in Maine.
The commission will work out charter language with Maine Connections Academy, which plans to open this fall with an initial enrollment of about 270 students in grades 7-9 and grow to a maximum of 750 students in grades 7-12.
Steve Mistler can be contacted at 791-6345 or at:
Twitter: @stevemistler
Were you interviewed for this story? If so, please fill out our accuracy form


text:
Simple and uncluttered team mailbox template. It's great for mailboxes like email@example.com or mailboxes that are shared among a few users.
Use this mail template to create mailboxes like firstname.lastname@example.com, email@example.com, firstname.lastname@example.com, etc. It's a simple mailbox template. There's no calendar or to-do. This mailbox is shared with other users and has its own Internet email address. What do you need in a Team Mailbox?
by Matthias Leonhardt 8 months ago
Discussion | German Template
by John F Ballam 1 year ago
by Jim Reilly 1 year ago
Review | Love app...any plans to update the UI?
by Lori Wiley 2 years ago
Bug | Memo Clips no longer RFC 2822.compliant
by Don Martindale 2 years ago
Feature | I would like to renew the request to make it webmail enabled with a look more like the modern mail template.
by Greg Gartland 3 years ago
Bug | Users can't move mail into folders
by Tibor R Bakhuis 3 years ago
by Nicole Lawson 3 years ago
by Robert Lindsay 3 years ago
Feature | Archive Function


text:
Postal service to consolidate sorting, close Akron center
A postal service spokesman says about 400 people work at the Akron facility.
A postal service spokesman says about 400 people work at the Akron facility.
The number of concealed-carry licenses issued or renewed last year in Ohio marked the first decline in several years.
More than two dozen protesters took to the streets to oppose the plan to bait, corral and kill deer.
American astronauts had 400 more feet of power and data cable to install Sunday.
Minoso made his major league debut with the Cleveland Indians in 1949
PennDOT has lifted the speed limit restriction that was in place for Interstate 80 in northwestern Pennsylvania.
Atlanta was the place where Gordon picked up his first NASCAR victory.
The annual event recognizes the accomplishments of the African-American community.
The Youngstown Phantoms continued their winning ways Saturday night with a win over Fargo.
The YSU men dropped another Horizon League game Saturday night against Milwaukee.
It's another big score for the Mexican government, which has been tearing through its list of most-wanted drug lords in recent years.
The YSU womens basketball team had a tough time with Green Bay Saturday evening.
The Kennedy Catholic girls basketball team defeated Cochranton, 44-29 Saturday to win their 5th straight Class A District 10 Title.
The Big Reds came up short against Harbor Creek Saturday in a 57-50 loss in the Class AA District 10 Title Game.
Nemtsov, a 55-year-old former deputy prime minister was gunned down as he walked near the Kremlin.
Kentucky Sen. Rand Paul has won the Conservative Political Action Conference's annual presidential preference straw poll.
President Nicolas Maduro announced that he will limit the number of U.S. diplomats allowed to work in Venezuela.
Police say a 60-year-old man has been crushed to death at a machine shop in Ohio.
The event is the biggest fundraiser of the year for the Primary Health Network Charitable Foundation.
Sophomore Spencer Demedal scored 17 points per game this season.
Jake Doddo and Matt Partridge both averaged in double figures for the Sailors.
Civil service workers joined union members from the UAW, Teamsters to protest the closure of the Youngstown Developmental Center.
Important Notice About Our Privacy Policy: We have modified our Privacy Policy to update and clarify our data collection, use, and disclosure practices.
By using this site, you agree to the updated Privacy Policy and Terms of Use


text:
You must register to post or download hacks.
If you are having any issues, shoot us an email, Contact MPGH Support. As always, have fun and enjoy your stay! - MPGH Staff
Ban my alt @Anime'
Last edited by Colourful; 07-25-2013 at 09:18 AM.
Proof that it's my alt.
Last edited by Anime'; 07-25-2013 at 09:19 AM.
Disregard this post.


text:
Meet ChargeKey - A charger on the go! This is a keychain sized charger that you will not leave behind. The ChargeKey, besides being a USB charging cable, also allows for syncing devices from any USB port.
There is hard plastic at both business ends of the cable, but it is soft and pliable in between letting it bend and twist as you please. A built-in keyring loop makes it even easier to carry along with your keys.
Own the worlds smallest USB cable and eliminate those low battery and unnecessarily long cable woes.
Options | Micro USB / iPhone |
This product ships from the US.
- Gallery
- Description
- Reviews