text: Potato yellow dwarf virus (ATCC® PVAS-233™) Classification: Nucleorhabdovirus / Strain: Constricta / Product Format: freeze-dried General Information History Documentation Print Email Share Share this product Facebook Twitter Google+ Permits and Restrictions View Permits Classification Nucleorhabdovirus Deposited As potato yellow dwarf rhabdovirus Agent Potato yellow dwarf virus Strain Constricta [PYDV Antiserum] Applications Plant research Biosafety Level 1 Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. Product Format freeze-dried Name of Depositor H Hsu, LM Black References . . CMI/AAB Descriptions of Plant Viruses No. 35: 1970.. Permits These permits may be required for shipping this product: Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment. Basic Documentation Product Sheet Certificate of Analysis SDS


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$26 billion is a terrible thing to waste. That's more than what NASA or the State Department spends in a year, and more than the annual foreign aid budget. Yet the taxpayers needlessly lost this much in the auto bailout.
Why "needlessly"? Because President Barack Obama could have kept General Motors and Chrysler running without losing money - had he not given the United Auto Workers special treatment.
Both the union and management mistakes pushed the automakers into bankruptcy. They were saddled with massive debts and product-quality problems, while the United Auto Workers raised labor costs above $70 an hour. The companies asked Washington for an outright bailout in 2009.
To his credit, Obama instead required GM and Chrysler to reorganize through bankruptcy. But the administration did not just finance the reorganization. It also insulated the UAW from the sacrifices unions usually make in bankruptcy. Three legal irregularities transferred tens of billions of dollars to the union.
First, union members got to keep most of their above-market compensation. Normally bankruptcy courts reduce union compensation to competitive rates. But the administration did not let that happen in Detroit.
The UAW agreed to cuts for new hires, while existing employees made only minor concessions. As the UAW told its members, the bailout meant "no loss in your base hourly pay, no reduction in your health care, and no reduction in pensions." GM still has higher labor costs than any of its foreign competitors. Even Steven Rattner, the president's former "car czar," admits that was a mistake.
Second, the UAW recovered a much greater part of its debts than other creditors. When they went bankrupt, the automakers owed tens of billions to a UAW benefit trust. The trust paid for UAW members to retire in their mid-50s with minimal out-of-pocket health-care costs for the rest of their lives. These debts had the same priority as other unsecured lenders, such as bondholders and trade creditors.
Bankruptcy law entitles similarly situated creditors to recover their debts at the same rate. The principle applies in corporate bankruptcies, but the administration ignored it.
Chrysler's unsecured creditors got nothing, while GM's unsecured bondholders recovered just 27 cents on the dollar. Legally, the union trust should have gotten the same amount. Instead the administration repaid the union nearly in full - which is why the UAW owns almost half of Chrysler. That money should have gone to the taxpayers.
Finally, General Motors spent $1 billion to top up the pensions of UAW members at Delphi. This is highly unusual. GM had no legal obligation to the workers of its bankrupt former parts subsidiary. It gave nothing to Delphi's non-union employees. Yet GM gave $1 billion of bailout funds to retired UAW members at a different company. That money did nothing to keep GM operating.
The administration has stonewalled investigators examining if it directed GM to make this payment. Key former members of Obama's Auto Task Force refuse to meet with the Inspector General. It is unclear why they would do this if they had nothing to hide.
In total these irregularities cost taxpayers $26.5 billion. These costs account for the entire net cost of the bailout. They also directly subsidized the UAW's above-market compensation. Taxpayers could have kept the automakers running, prevented layoffs, and broken even. That didn't happen, and only because the administration gave the union special treatment.
UAW members are naturally glad they avoided larger sacrifices, but that doesn't justify their bailout. The typical UAW member at GM still makes twice what the average private-sector worker does. Few other Americans can retire at 56 or get retirement health benefits on top of Medicare.
The government should not use the taxes all Americans pay to prop up union compensation, especially when the national debt is exploding. High pay is good, but it must be earned through productivity and hard work, not taken from others through taxes.
The administration spent twice as much subsidizing UAW pay as the Labor Department spends on job training programs. This spending did not serve a greater public good. Normal bankruptcy financing would have kept the automakers in businesses without losing money.
Obama didn't bail out the auto industry. He bailed out the United Auto Workers.
James Sherk is senior policy analyst in labor economics at the conservative Heritage Foundation. Todd Zywicki is a law professor at George Mason University. Readers can write to the authors in care of The Heritage Foundation, 214 Massachusetts Avenue NE, Washington, D.C. 20002.

subset: commoncrawl


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Video editing required urgently ( Must be an arab speaker)
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About Ellana G.
Special needs
Ellana is a current university student, working on her dual degree in mathematics and computer science. She has been a permanent academic tutor to over 30 students, with an approach geared towards interpreting and explaining the foundation of the given subject. With experience in multi-variable calculus, linear algebra, discrete mathematics, statistics and probability, theoretical advanced mathematics, algebra, trigonometry, geometry, and common curriculum mathematics, Ellana uses techniques learned in each field to help with standardized testing, i.e. regents exams, SHSAT, SAT, AP exams, PSAT, and of the like.
Customized exam preparation is administered upon initial approach to the planning and studying process, which is tailored individually to each student.
As a current CPA firm employee, as well, Ellana is a fitness activist who allocates her free time to cycling, running, and weight strengthens and endurance. Life planning and coaching in this field is available.
Please reach out to discuss any questions.
Accounting Administrator
Oct 2014 - PresentAddress clients' businesses, referencing taxes; bookkeeping
Mar 2014 - Jan 2015Worked alongside various political candidates, including State Assembly candidate, by reaching out to residents regarding specific district issues and how they can be amended; organized canvassing leads results
Jan 2014 - Jan 2015Strived to enrich life of handicapped high school student by engaging in sports activities, musical activities, and games
Web Designer
Jan 2013 - Jan 2015Created informational brochures to distribute to potential clients; assisted in re-outfitting and repairing electronic devices; designed and maintained website
Mathematics and Computer Science
Sep 2014 - PresentViolinist
Jan 2014 - Jan 2015Languages Spoken
Jul 2015Affiliations
American Alliance for Health, Physical Education, Recreation and Dance
Jun 2016AAHPERD is the largest organization of professionals involved in physical education, physical activity, dance, school health and sport--all specialties related to achieving an active, healthy lifestyle.
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Novartis meningitis B vaccine Bexsero® receives FDA Breakthrough Therapy designation in the US
- The designation highlights the potential of Bexsero to meet the urgent need for a licensed vaccine in the US against unpredictable and devastating meningitis B[1]
- Bexsero, already approved in Europe, Canada and Australia, is the only broad coverage meningitis B vaccine that can be used from two months of age[2],[3],[4],[5]
- Bexsero was recently provided to two US universities under an Investigational New Drug (IND) designation; Novartis plans to file in the US as early as Q2 2014[6],[7]
Basel, April 7, 2014 - Novartis announced today that Bexsero® (Meningococcal Group B Vaccine [rDNA, component, adsorbed]) has received a Breakthrough Therapy designation from the United States Food and Drug Administration (FDA). Bexsero is already approved in Europe, Canada and Australia to help protect against invasive meningococcal disease caused by serogroup B (meningitis B)[2],[3],[4],[5]. Novartis plans to file for US licensure of Bexsero as early as Q2 2014; exact timing will depend on guidance from the FDA. This is the fourth Breakthrough Therapy designation for Novartis, underscoring leadership in developing innovative therapies and vaccines[8],[9],[10].
This announcement comes on the heels of a landmark decision from regulators in the UK, where the Joint Committee on Vaccination and Immunisation (JCVI) recommended the inclusion of Bexsero in the country's National Immunisation Programme (NIP) for routine use in infants from two months of age[11].
In the last four months, Novartis has provided nearly 30,000 doses of Bexsero to students and staff at Princeton University and the University of California Santa Barbara (UCSB) following meningitis B outbreaks on their campuses under an Investigational New Drug (IND) designation from the FDA[6],[7],[12]. Further, the US Centers for Disease Control and Prevention (CDC) have recommended including the incoming freshman class at Princeton University in the at-risk group to receive Bexsero.
"The recent outbreaks on US university campuses have shown that meningitis B is unpredictable and can strike at any time with devastating consequences," said Andrin Oswald, Division Head, Novartis Vaccines. "A US license for Bexsero is the only sustainable solution to ensure timely responses to future outbreaks and to provide access to parents and physicians across the country. We will continue to work with the FDA to bring Bexsero to the US as soon as possible."
According to the FDA, Breakthrough Therapy designation is intended to expedite the development and review of new medicines that treat serious or life-threatening conditions. The designation includes all of the fast track program features, as well as more intensive FDA guidance[13]. Meningitis B is the leading cause of bacterial meningitis and septicemia in the developed world[14]. With vaccines currently available in the US to help prevent the other four most common serogroups that cause meningococcal disease (A, C, Y and W), a licensed vaccine offering protection against serogroup B remains an unmet public health need in the US[1]. Today's announcement also highlights Novartis' leadership in developing innovative vaccines against meningococcal disease, as the only company with licensed vaccines for all five main serogroups that together cause the majority of cases in the world.
Meningitis B is a rare but aggressive disease that can kill or cause serious life-long disability within 24 hours of onset[15]. Because initial symptoms are often unspecific and flu-like, it can be difficult for even a healthcare professional to diagnose the disease in its early stages[16]. About one in 10 of those with the disease will die despite appropriate treatment and of those who do survive, one in five will suffer from devastating, life-long disabilities such as brain damage, hearing loss or limb loss[15]. Vaccination is therefore the best defense against the disease which leaves little time for intervention.
The foregoing release contains forward-looking statements that can be identified by words such as "Breakthrough Therapy," "potential," "unpredictable," "plans," "will," "recommended," "can," or similar terms, or by express or implied discussions regarding potential marketing authorizations for Bexsero, or regarding potential future revenues from Bexsero and other Novartis vaccines. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that Bexsero will be submitted or approved for sale in any additional markets, or at any particular time. Nor can there be any guarantee that Bexsero or such other Novartis vaccines will be commercially successful in the future. In particular, management's expectations regarding Bexsero and such other Novartis vaccines could be affected by, among other things, unexpected regulatory actions or delays or government regulation generally; the uncertainties inherent in research and development, including unexpected clinical trial results and additional analysis of existing clinical data; the company's ability to obtain or maintain proprietary intellectual property protection; general economic and industry conditions; global trends toward health care cost containment, including ongoing pricing pressures; unexpected manufacturing issues, and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.
About Novartis
Novartis provides innovative healthcare solutions that address the evolving needs of patients and societies. Headquartered in Basel, Switzerland, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, eye care, cost-saving generic pharmaceuticals, preventive vaccines and diagnostic tools, over-the-counter and animal health products. Novartis is the only global company with leading positions in these areas. In 2013, the Group achieved net sales of USD 57.9 billion, while R&D throughout the Group amounted to approximately USD 9.9 billion (USD 9.6 billion excluding impairment and amortization charges). Novartis Group companies employ approximately 136,000 full-time-equivalent associates and operate in more than 140 countries around the world.
For more information, please visit http://www.novartis.com.
Novartis is on Twitter. Sign up to follow @Novartis at http://twitter.com/novartis.
[1] Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book: Course Textbook). 12th Edition, 2nd printing. May 2012 update. Available at: http://www.cdc.gov/vaccines/pubs/pinkbook/mening.html. Accessed on April 2014.
[2] EMA. Authorization Details for Bexsero. Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002333/human_med_001614.jsp& mid=WC0b01ac058001d124. Accessed April 2014.
[3] EMA. EU Member States. Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/partners_and_networks/general/general_content_000219.jsp&mid=WC0b01ac058003174e. Accessed April 2014.
[4] Health Canada. Bexsero. Available at: http://www.hc-sc.gc.ca/dhp-mps/prodpharma/sbd-smd/drug-med/sbd_smd_2014_bexsero_147275-eng.php. Accessed April 2014.
[5] Australian Government: Department of Health: Therapeutic Goods Administration. Available at: http://www.tga.gov.au/pdf/auspar/auspar-meningococcal-131031.pdf. Accessed April 2014.
[6] Centers for Disease Control and Prevention. Princeton University Meningococcal Disease Outbreak. December 2013. Available at: http://www.cdc.gov/meningococcal/outbreaks/princeton.html. Accessed April 2014.
[7] Centers for Disease Control and Prevention. University of California, Santa Barbara Meningococcal Disease Outbreak. January 2014. Available at: http://www.cdc.gov/meningococcal/outbreaks/ucsb.html. Accessed April 2014.
[8] Novartis Press Release. "Novartis compound LDK378 receives FDA Breakthrough Therapy designation for ALK+ non-small cell lung cancer." Available at: http://www.novartis.com/newsroom/media-releases/en/2013/1685517.shtml. Accessed April 2014.
[9] Novartis Press Release. "FDA grants Breakthrough Therapy designation to Novartis' serelaxin (RLX030) for acute heart failure". Available at http://www.novartis.com/newsroom/media-releases/en/2013/1711047.shtml. Accessed April 2014.
[10] Novartis Press Release. "Novartis receives FDA breakthrough therapy designation for BYM338 (bimagrumab) for sporadic inclusion body myositis (sIBM)." Available at: http://www.novartis.com/newsroom/media-releases/en/2013/1723765.shtml. Accessed April 2014.
[11] JCVI Minutes February 2014. Available at: https://www.gov.uk/government/policy-advisory-groups/joint-committee-on-vaccination-and-immunisation. Accessed April 2014.
[12] Novartis Data on File.
[13] US Food and Drug Administration. Frequently Asked Questions: Breakthrough Therapies. Available at: http://www.fda.gov/regulatoryinformation/legislation/federalfooddrugandcosmeticactfdcact/significantamendmentstothefdcact/fdasia/ucm341027.htm. Accessed April 2014.
[14] World Health Organization. Bacterial Meningitis. Available at: http://apps.who.int/nuvi/meningitis/en/. Accessed April 2014.
[15] World Health Organization. Meningococcal Disease Fact Sheet 141. Available at: http://www.who.int/mediacentre/factsheets/fs141/en/. Accessed April 2014.
[16] National Meningitis Association. "What are the Symptoms?" Available at: http://www.nmaus.org/disease-prevention-information/what-are-the-symptoms/. Accessed April 2014.
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Indiana's Kevin Wilson gets the dreaded vote of confidence
It's never good to have your AD defending you in your second season. (US Presswire) |
There's never a good time to get the dreaded vote of confidence from your athletic director, but it's a really bad sign when your athletic director feels the need to defend you even though you're only a month into your second season as coach.
That's what Indiana coach Kevin Wilson is dealing with at the moment, as Indiana athletic director Fred Glass went to bat for his football coach while talking to the Indianapolis Star.
"We absolutely have the right guy and absolutely have the right staff," Glass told the paper. "I gave him a seven-year contract, and we're going to stick with him. For a variety of reasons, both voluntarily and involuntarily, we haven't stuck with a football coach since Bill Mallory.
"Our goal was to find the right guy, give him the resources to be successful and then stick with him so we get the benefit of building something. And I absolutely believe we have the right guy in Kevin Wilson."
Glass isn't kidding about the coaching turnover in Bloomington. Since Mallory's final season in 1996, Kevin Wilson became Indiana's fifth coach in 14 seasons. None of those coaches have managed to win 40 percent of their games, with the late Terry Hoeppner coming the closest.
Wilson's start in Bloomington isn't promising, either. Through his first 16 games with the Hoosiers, he has a 3-13 record. Those three wins came against South Carolina State, Indiana State and Massachusetts. Both South Carolina State and Indiana State are FCS programs, and Massachusetts -- which Indiana beat in September -- was an FCS program just last season.
Still, firing a coach during or after his second season is too early, unless there's an exterior reason for his dismissal like an arrest. It's not like the program that Wilson, who previously was offensive coordinator at Oklahoma, took over was primed for success. It's only fair that he be given at least three seasons to show progress before Indiana considers replacing him.
Doing otherwise doesn't help anybody.


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Have I got some Red Gift ideas for you? Make Christmas fun for your man by buying him a few of these items!
1. Lingerie (for him to open, but you to wear)
2. A box of Red Hots with your husband's picture on it.
3. Matching boxers
4. Warming lotion (use a coffee warmer to keep it warm)
5. PJs (You wear the top, he wears the bottoms)
6. A card with 10 reasons why you are grateful for everything he does
7. 21 Post it notes around your room of reasons you love him
8. Mistletoe on the headboard of your bed
9. A box of chocolates (with instructions for the two of you to share them in bed.)
Don't forget to listen to this week's podcast – Naughty…and nice holiday gifts for your man — RED GIFTS!
Photo courtesy of Free Digital Photos. (http://www.freedigitalphotos.net/images/Christmas_g54-Santa_Woman__Holding_A_Gift_Box_p123859.html)
She and her husband Roger are the parents of four young adults in San Jose, CA. When she's not dating her husband or hanging out with her puggle Jake, Kathi is speaking at retreats, conferences and women's events across the US.
Latest posts by kathilipp (see all)
- Tired of Cleaning Up Piles of Mess? The One-Touch System - March 9, 2017
- Love Intentionally: Celebrating Romance All Year Long - February 17, 2017
- Love Intentionally: Stop Talking Bad About Our Husbands - February 16, 2017


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Nashville had an entertaining week from Sunday, October 9th to Sunday, October 16th and experienced great live performances due to tour routing that led to several Hip-Hop acts converging on the city in a seven day span. One Sunday saw our LivexDirectTN stage – a merger of the Hip-Hop & Love (Murs, tabi Bonney, Ski Beatz, e. al.) and L-R-Generations (9th Wonder, Freddie Gibbs, etc.) tours – followed by a Thursday night show featuring Das Racist and Danny Brown with his Bruiser Brigade brothers Dopehead & Chip$. Rounding out the seven-day rap-a-thon was Wale's "Ambition" tour, featuring Black Cobain and local support.
If you're city's music scene sucks, band together with others and create the scene you envision. Shouts out to everybody involved — The artists, the people behind the scenes and the people in the crowds.


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Staff Selection Commission invited application for the recruitment of GD Constable ,any citizen of India may apply for the post of BSF, CRPF, CISF, ITBF, SSB, NIA and SSF. The Advertisement has been released online. Apply online official website of Staff Selection Commission. The candidates age should be 18 to 23 years as on 01.08.2017. The candidates must have minimum academic qualification of Matriculation passed. Eligible candidates details like age limit, educational qualification, selection process, how to apply are given below..
SSC GD Constable Recruitment 2017 Apply for BSF, CRPF, CISF, ITBF, SSB, NIA, and SSF post www.sscsr.gov.in
Organizer Name:- Staff Selection CommissionApply For:- BSF, CRPF, CISF, ITBF, SSB, NIA and SSF.
Total Vacancy to be filled:- For Male candidates 53857 post and for female candidates 62390 posts.
Age Limit:- 18 to 23 years as on 01.08.2017
Education Requirement:- Minimum Matriculation
Official Website:- www.ssc.gov.in
Post & Vacancy Details:-
The candidates may apply for the GD Constable post i.e. BSF, CRPF, CISF, ITBF, SSB, NIA, and SSF.
Pay Scale:
Pay Band 1 Rs. 5200 to 20200 with Grade Pay of Rs.2000/.
Education Requirement:-
The candidates may apply for the GD Constable post, candidates must have to complete their Matriculation (class 10th) or its equivalent exam from the recognized board or council.
Age Limit:
Candidates who will apply for the post of GD Constable after the final publication of Official Recruitment Notification, their age limit must be in between 18 to 23 years as on 01.08.2017. The age relaxation permissible for the SC and ST candidates are 5 years, for Ex-serviceman (Unreserved / General) 3 years relaxation, for Ex-serviceman (OBC) 6 year relaxation, for Ex- serviceman (SC/ST) 08 years relaxation. Candidate who had ordinarily been domiciled in the State of Jammu & Kashmir
Selection Process:
The recruitment process will consist of Physical Standards Test (PST), Physical Efficiency Test (PET), Written Examination & Medical Examination.
Physical Standards Test / Physical Endurance Test will be scheduled and conducted by CAPFs. Call Letter to candidates will be issued / uploaded on their website by the coordinating CAPF / CRPF.
The Commission will conduct written examination of candidates qualified in PST / PET in both Online (Computer based) and Offline (Paper Mode) .
Online examination will be in English & Hindi only. Offline examination will be in English, Hindi and other Regional languages mentioned in official advertisement.
Examination Fees:
Application Fee is Rs.100 (for all Un-Reserved candidates). Fee paid by modes other than SBI Challan or Online payment through SBI Challan / Net Banking / Credit Card and Debit Card from State Bank of India, as stated above, will not be accepted and the applications of such candidates will be rejected forthright and the payment made shall stand forfeit.
Fee is exempted for all Women candidates and candidates belonging to Scheduled Caste, Scheduled Tribes, Physically Handicapped and Ex Serviceman eligible for reservation.
Application Procedure:
The online submission of the application may be be made at website www.ssconline.nic.in. Instructions are available on the Staff Selection Commission Online website. Candidates should read the instructions carefully before making any entry or selecting options. Candidates should supply all the required details while filling up the online form.
In Registration part, candidate will have to fill basic Information, on submission of details, candidates shall be prompted to check the details and make any correction in the registration.
Then a page with Registration ID and Passwords will appear. Note down the Registration ID and password and keep it safely. The application procedure is incomplete without application part. Application part requires filling on payment details, uploading photograph and scanned signature . Online application will be complete only if scanned signature and photo are uploaded as per instructions.
Other Details Update after Publish Official Notification 2017 (www.ssc.nic.in)


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Our long-term goal is to define the molecular mechanisms by which Ca2+ oscillations in osteoclasts (OCs) contribute to bone remodeling and provide the basis for guiding more effective therapies to promote skeleton health. Recent breakthrough studies have shown RANKL-evoked Ca2+ oscillations play a switch-on role in inducing NFATc1 activation and OC differentiation. However, the factors induced by RANKL that initiate and maintain Ca2+ oscillations for OC differentiation and how Ca2+ oscillations induc osteoclastogenesis at the molecular level are still largely unknown. Our recent investigations suggest that Regulator of G-protein Signaling 12 (RGS12), a multi-domain and the largest protein in the RGS family, plays essential roles in Ca2+ oscillations and OC differentiation. We deleted RGS12 in hematopoietic lineage cells using inducible Mx1-cre and found that the mutant mice (RGS12?/?/cre) are osteopetrotic with significantly reduced OC numbers and bone resorption. Additionally, we found that RGS12 directly interacts with N-type Ca2+ channels and calcium- sensing receptors (CaRs), likely through phosphotyrosine-binding (PTB) and RGS domains, and that ectopic expression of RGS12 and its PTB domain respectively increases RANKL sensitivity during OC differentiation. It is known that the G protein-coupled CaRs play a pivotal role in controlling signaling pathways involved in OC differentiation and survival and maintaining extracellular Ca2+ concentrations, and that RGS proteins play essential roles in modulating CaRs and stimulating PLC? activity by inhibiting G?i signaling. Furthermore, cytosolic Ca2+ oscillations are generated mainly by influx of extracellular Ca2+ through L- and N-type calcium channels, and that RGS12 is capable of direct interaction with N-type Ca2+ channel through its PTB domain and modulates channel activity. Based on these findings, our central hypothesis is that RGS12 is required for Ca2+ oscillations in OC differentiation and function, and that RGS12 interacts with G?i protein, CaRs, Ca2+ channels, and other heterodimerization partners to regulate the RANKL-induced Ca2+ oscillation-NFATc1 pathway during OC differentiation. We will test this hypothesis through two specific aims:
Aim 1, we will determine where in the OC lineage RGS12-induced Ca2+ oscillations are required for OC differentiation and function in bone development and remodeling by analyzing the bone phenotype of RGS12 mutant mice with deletion of RGS12 at early and late stages of OC differentiation using RGS12flox/flox/Mx1-Cre, RGS12flox/flox/LysM-Cre and RGS12flox/flox/CathepsinK-Cre. We will further etermine the role of RGS12 in the enhanced bone resorption and formation that occurs after OVX. We will then characterize the role of RGS12 in regulating Ca2+ oscillations, OC differentiation and function at early and late stages of OC differentiation in vitro.
Aim 2, we will investigate the signaling pathways that impair OC differentiation in RGS12?/?/cre mice. We will further elucidate the mechanism by identifying and characterizing the functional domains of RGS12 and their heterodimerization partners involved in RGS12-induced Ca2+ oscillation in OCs.
Osteoporosis is a major public health threat affecting approximately 44 million women and men aged 50 and older in the US which results in 1.5 million fractures annually with the cost of $12 billion to $18 billion for caring of these fracture. Moreover, the current treatment options such as bisphosphonates, selective estrogen receptor modulators and parathyroid hormone have been constrained with lower response rates or side effects and ineffectively tackle the quantitative burden and heterogeneity of osteoporosis. Thus, identifying new proteins such as RGS12 which target bone resorbing osteoclasts and bone remodeling has potential to provide a significant impact on patients.
Showing the most recent 10 out of 11 publications


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World Wildlife Fund Canada has released a sobering oil-spill model for the Beaufort Sea that suggests a major blowout would contaminate ecologically sensitive shorelines in Canada and Alaska and seriously impair the livelihood of coastal Inuit communities.
The WWF report released Friday comes as Imperial Oil Ltd. and Chevron Corp. are separately preparing for reviews by the National Energy Board and Inuit-led environmental panels on their plans to begin drilling for oil in the deep water of the Beaufort Sea by the end of this decade. The companies will be submitting their own environmental assessments – including worst-case spill scenarios – as part of those hearings.
Prior to that, both Imperial and Chevron will apply for an exemption from the NEB's requirement that companies be able to kill a potential blowout with a relief well in the same season that the accident occurs. The companies maintain that a strict interpretation of the same-season relief well (SSRW) regulation would prevent development in the Beaufort Sea. The regulator has said it would grant a waiver if the companies can demonstrate they had alternatives that would be as effective.
In anticipation of their drilling applications, WWF Canada commissioned RPS Applied Science Associates Inc. to model the spread and fate of potential oil spills associated with increased ship traffic and offshore petroleum exploration and development in the Beaufort.
The consultants concluded that, in a major blowout, oil would spread rapidly due to currents and high winds, would become trapped in the sea ice, making cleanup virtually impossible, and would have a high probability of reaching the shores of Alaska's Arctic National Wildlife Refuge. The use of chemical dispersants could result in toxic concentrations of dissolved oil in the water column along the Beaufort shelf, which is home to species that are critical to the Arctic ecosystem.
WWF Canada worked with the Inuvialuit Game Council on the report, and planned a series of meetings with local communities to review its findings. The spills report will help the local people better understand the impact of oil spills on their environment, said Frank Pokiak, chairman of the Inuvialuit Game Council, which participates in those assessments.
"One spill in the Beaufort would be devastating to the Inuvialuit and the marine species and wildlife that we harvest," Mr. Pokiak said in a telephone interview. "We know that there is going to be risk in the offshore activity that is happening. So we're still dealing with those issues and haven't decided on a position."
WWF president David Miller said the spills study demonstrates the enormity of the risk from deep-water drilling.
"It is incumbent upon industry now to show there is a plan to manage the risks, and based on what we've seen to date that's going to be extremely difficult for them to do, particularly in deep-water wells," he said.
In filings on their Arctic plans with the National Energy Board, the companies have acknowledged that a major blowout would have serious consequences, but can be prevented.
"We believe that our proposed approach – using best available technology and applying best safety practices and standards – is consistent with the National Energy Board's stated commitment to goal-based regulation in ensuring the highest levels of protection in offshore Arctic drilling," Imperial Oil spokesman Killeen Kelly said in an e-mail on Friday.
"Procedures will be developed to ensure safe operations in the Arctic offshore environment, including drilling program design, processes, equipment and personnel training. Foremost, our primary approach to well control is prevention of incidents."
In a May letter to the board, Chevron said it is proposing to use new technology that will provide a fail-safe barrier against blowouts, as an alternative to same-season relief wells.
Report Typo/ErrorFollow @smccarthy55
on Twitter:- Chevron Corp$106.28-1.71(-1.58%)
- Imperial Oil Ltd$41.03-0.26(-0.63%)
- Updated March 27 4:00 PM EDT. Delayed by at least 15 minutes.


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Publisher: | Dwayne Rothe - DinkumSoft | Date added: | 05 November, 2007 |
License: | Shareware | ||
Price: | $0.94 | ||
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In this medium-length (53 minutes) French-U.S. documentary made for European television, black filmmaker Melvin Van Peebles examines African-American film history. Narrating while clips, stills, and location shots are seen behind him in a rear projection, Van Peebles' commentary covers a wide range of racial stereotyping. Beginning with early silent films, even prior to more
All Classified X cast + crew photos


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When I got my new couches I also bought a new side table, so I decided my crappy old lime green coasters werent gonna cut it.
I found this blog, where they have a tutorial to make crooked coasters
giving all of us an excuse to let our machines do the walking… haha lame joke.
Material Notes
I made mine from white and olive green linen
- For
- Home/Deco
- Garment Type
- Accessories
- Style
- Bohemian, Preppy
- Material
- Linen


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rusty jim
a s*xual act in which one partner eats out the other one's *n*s.
time for a rusty jim!
Read Also:
- valenbro
this is a term used to address your male friend on valentine's day if you wish to give him something without implying that you have feelings for him. "hey, i heard you didn't have a valentine. i don't have one either. will you be my valenbro?"
- aydryanna
shes the prettiest girl you will ever see and her smile is amazing she will make any boy jealous without trying and is agreat friend the girl aydryanna is cute.
- she f*cking died
when some girl f*cking dies person 1: in my book, this one girl died. person 2: she f*cking died?!
- everetts d*ck
a d*ck the size of mount everett: approximately 2600 feet you know jason? he's got an everetts d*ck.


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William Hague is in danger of throwing away his best chance to strike while Tony Blair is off-balance. The crisis of confidence inflicted on the Government by the fuel-tax protest is the Conservative leader's big opportunity.
William Hague is in danger of throwing away his best chance to strike while Tony Blair is off-balance. The crisis of confidence inflicted on the Government by the fuel-tax protest is the Conservative leader's big opportunity.
So what is his opening gambit for this week's party conference? More public money for pensioners than whatever Gordon Brown comes up with. This is the politics of the playground, where the argument is won by being the first to promise a pension of "1p a week more than anybody else says" or "infinity pounds a week". How on earth can a serious political party set its tax and spending plans in relation to the as-yet-unannounced plans of another party?
This fiscal illiteracy also fixes our attention on the central weakness of the Conservative case: that it is promising simultaneously higher public spending and lower taxes. It is a contradiction that undermines Tory policy on schools, hospitals, fuel duty and a lot else besides.
What is worse, the promise to spend more than the other lot has deflected attention from the one serious and genuinely radical proposal that Mr Hague is making about long-term pension provision.
He suggested yesterday that young people should be allowed to opt out of the state pension and invest their National Insurance contributions in a private pension instead. That, contrasted with Labour's antique struggle over restoring the link between the state pension and the average earnings index, is much more the kind of free-market policy of individual responsibility that the Tories ought to adopt.
In this, Mr Hague's pensions policy fits into a wider pattern, in which the libertarian, inclusive instincts of his past have been overridden by the urge to jump on every passing bandwagon. Thus we have had a series of inauthentic Hague pronouncements on crime, the family and the rise in the number of unfounded claims for refugee status.
What the Conservative Party needs is to combine the liberal approach to economics and social policy that can be discerned in Michael Portillo and the early Hague with the One Nation ideals of Kenneth Clarke and John Major. Mr Hague's tragedy is that he seems to have been persuaded to suppress his own instincts in favour of an unattractive and unconvincing populism.
Following tales of his youthful drinking exploits, he boasted yesterday that he had "strangled one guy" in a judo bout. He should know that judo is not about aggression but about self-discipline. If he is to use Mr Blair's loss of momentum against him, he needs to fight a cleverer fight this week.


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Congratulations to Ethan Davis who received a positive office referral this week for #doingtherightthing.
Ethan volunteered to help a fellow students get logged into his computer and also helped the student to find where he needed to be while encouraging him to try hard and do his best. Ethan exhibited compassion, citizenship, and encouragement. Keep up the good work, Ethan.
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This is a page where you can find photos of Tan Son Nhat Domestic Airport (Ho Chi Minh City, Vietnam), trip reviews, comments, and Logbooks (Travelogs) with information and pictures related to Tan Son Nhat Domestic Airport. If it piques your interest, how about reading the reports written by other travelers who actually went to Ho Chi Minh City, Vietnam and saw Tan Son Nhat Domestic Airport?
Kasumi Jou
Takahumi Taneichi
Salt Mint


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Two young wizards of Earthsea, Ged and Vetch (Ged is the one with the scars on his face). Behind Ged, the Shadow. A wonderful image by Paul Duffield, one of the very few images that manage to do justice to the spirit and the substance of the "Trilogy of Earthsea" by Ursula Le Guin.
Any sufficiently advanced technology is indistinguishable from magic. (Arthur C. Clarke)
Long ago, one of my teachers in high school said that the existence of the Middle Ages in history was justified because it had produced such a genius as Dante Alighieri and a masterpiece such as the Comedy. Surely, there is virtue in genuine enthusiasm and it is true, in my opinion, that some ages are characterized - and perhaps justified - by the literature they produce.In this light, I came to think that if the second half of the 20th century had something comparable to Dante's Comedy, that might well be Ursula Le Guin's "Trilogy of Earthsea".
It takes little effort to identify the elements of the fictional Earthsea universe that couple with the corresponding elements in our world, with magic being the Earthsea equivalent of science and technology in our world. Of course, that has to be taken with some caution: it is an old cliché that of saying, for instance, that a girl's eyes are like stars, and then go on describing stars while referring to the girl's eyes. Shakespeare could do that, but Shakespeare was Shakespeare; for a modern writer, allegory is a deadly trap. But in Le Guin's work (just as in Dante's) allegory goes way beyond banality. It has been said that true writers don't think in symbols and I am sure that Le Guin never planned the allegorical two-way correspondences in her world and ours. But, no matter what mental process produces symbols, good literature teems with them. Le Guin's writing, then, sprouts out symbols like a Medieval cathedral sprouts out gargoyles.
So, what is the Earthsea world telling us? To explain my point, I have to start from far away. Imagine that you have never been exposed to the thousands of years of accumulation of what we call "culture". Culture is a way of classifying and categorizing; it tells you that things may be organic/inorganic, hard/soft, good/bad, friendly/unfriendly, etcetera. But imagine that you are looking at the world with fresh eyes; as if seeing it for the first time. You see all sort of things: people, animals, rivers, rocks, building, mountains, and much more. And you try to make some sense of all that. So, you notice that some things move, grow, shrink, and change shape. There seems to be some hierarchy in this kind of entities; some move fast and some slow, some don't move at all, but that doesn't mean they never do (think of a volcano). Let's say that that you could think that all things have a soul; in a way they are like you, there is a certain kinship in all things.
So, if things have a soul, then you can speak to them. To people, you can talk and they talk back to you. You can do that also with animals; they won't talk back to you but they may listen. You can talk to plants, streams, and rocks; who knows? They might be listening. You may well try to convince the sky to produce some rain when you need it. Praying, dancing, offering sacrifices. That's the origin of what we call "religion", that's a very, very old way of understanding the universe. The universe has a soul. It is a soul. It is the definition of God (or of the Gods).
But there is also another way of understanding the universe: it is to assume that it is a sort of a machine. A machine is not something you talk to; it is something you act upon. And if you act in the right way, it will react predictably and as expected. So, you may pray to get the benevolence of the soul of a great forest tree, but you may also chop it down with an axe. You can do the same with an enemy: if you bump his head with a battle axe, the results will be predictable. If you know the functioning of the machine, then you can make it behave as you want to. This is the origin of Magic; that some also call "craft". Finding the rules that things follow gives you power on them.
Religion may be older than magic, but they seem to have been going in parallel in human history. Take one of the oldest Western pieces of literature, the Iliad, and you'll find Gods appearing on almost every page, but no wizard ever crosses them. But, in the "Odyssey"; you have an almost prototypical witch; Circe, who turns people into pigs, although she is also described as a Goddess. In some of the earliest literature we have, the Sumerians left us plenty of healing recipes where they freely mix invocation to Gods with herbs and other substances that surely had some healing powers of their own.
In time, Religion and Magic diverged more and more to the point that most modern religions despise magic as evil. Priests may well perform rituals to obtain something for the benefit of the faithful, but they are always careful to state that success or failure is never guaranteed. If you pray God (or the priest does that for you) you may ask Him that He would cure your ailment. If you are cured, then you are supposed to thank God for His benevolence. But the ailment doesn't disappear or you get worse, then you are not supposed to blame God for that. The divine will is unfathomable and it may be argued that it is your fault because of some sin you committed that made you unworthy of God's benevolence. A win-win condition for the priests, for sure.
Over history, magic took different paths. One was that of the Europan alchemists. They tended to renounce to all the dark incantations of old times and they became true empiricists, originators of what we call the "scientific method". Their theoretical basis was faulty and they lost a lot of time in tasks that today we recognize as impossible. But they were always in search for things that worked. Modern science is a wary of recognizing their role, but the basic idea is the same: the world is a machine: you don't need Gods to operate on it. And, in a certain way, the daughter of alchemy, science, triumphed. In most of the Western World, when people want to be cured of their sickness, they trust a doctor more than a priest; even though they may also pray God to give them a hand, just in case. But praying God is way more unreliable than taking a pill or undergoing surgery.
There is a problem with the universal machine, though. Magic, just as Science, has no moral compass: the end result of magic doesn't depend on whether it is done for a good or a bad purpose. Science-based medicine will unflinchingly cure an evil person while the best modern technologies have developed weapons that will kill anyone. And this is a big problem especially when science fails - and it does. While you can't sue God for malpractice, you can and you do that when you think a doctor did something wrong to you or to someone close to you. And modern science has been unable to maintain its promises and it is been as an evil form of black magic for having lost control on those that it did manage to deliver; think of nuclear energy as an example.
Now, let's go back to Earthsea. It is a society nearly fully based on magic, just as our modern world is nearly fully based on science. That allows Le Guin to dissect the moral dilemmas of science in a variety of narrative plots. Earthsea is a machine all based on the "old speech" that plays the same role as mathematical models in our world. This old speech, in other words, is something like an instruction manual for the world machine. Then, the novel describes idealized scientists - portraited as wizards. They are benevolent, crafty, intelligent, and always worried about not doing damage to the equilibrium of things. One wishes our scientists were like that! But, even the wise mages of Earthsea have problems. One is that they can do very little; we see them mending broken vases, curing goats' infected udders, raising - sometimes - the magewind to push boats, and curing human ailments only when they are not too serious. So, they are at times considered as useless and rejected. One of the stories of the series deals with an age in which wizardry had fell from grace and was widely despised. Just like what may soon happen to science in our world.
True, the protagonist of most of the stories, Ged, also fights dragons, but dragons are not a problem; they are more part of the danger of doing science, a little like nuclear energy. The real problem with magery in Earthsea is the same we have with science in our world: the lack of a moral compass. So, in the first story of the series, Ged's enemy is not a dragon but himself. And, later on, it will be another mage, turned evil. Over and over, the mages of Earthsea are at loss on how to deal with the Otherworld; the realm of the dead. A realm that's alien to magic and to science, but that's the natural domain of religion.
Le Guin's view of the Otherworld is nearly identical to the Sumerian one reported in the Epic of Gilgamesh and the interaction of the dead and the living is a theme that goes through the whole series; concluding it in a way that's a pure rendition of the Buddhist concept of Nirvana. The dead vanish in a puff of smoke, but the problem remains and it is one that neither science nor magic can solve.
So, Earthsea is not a Godless world; it can't be. It was created by Segoy; who maybe is a dragon, or maybe he is a God. And it is hinted that there is something more; much more than that and at least one region of Earthsea, the Kargad Lands in the North, are described as dominated by a religious vision of the world. Initially, the Kargish are just pirates and barbarians, but then they take up power and importance in the stories, hinting that their view may be on a par - perhaps superiors to their crafty Southern Neighbors. It is like that: Earthsea is a real world, it is alive. Le Guin says that she won't write more novels about it, but that doesn't matter. It was another writer, Jorge Luis Borges, who said that a writer only adds pages to a giant book that's being written by all the previous writers.
So, as I am writing these note, I am almost overwhelmed at the vastity and the complexity of what I am trying to describe. The Earthsea universe is so complex that to describe it you would need to write another complete Earthsea cycle. Something like what Borges had one of his characters trying to do, becoming capable of rewriting the Don Quixote, exactly as Cervantes had written it. Or, maybe, you need to live in Earthsea, as Ursula Le Guin has probably done. So, in the end, what's the point of creating a whole new universe which has the same problems we have with ours? Maybe creating universes is unavoidable for some people with truly awesome creative powers. Maybe there is no rational justification for doing it, it just happens. And maybe these universes are not created by anyone, they just exist and they are described by some people who have the gift of seeing them.
Maybe we should just read about Earthsea for the pure joy of doing that. Or, maybe, we can read it in order to learn something about the contradictions and the problems of our world. What's all our science for? Can it solve problems or does it just create more of them? Can we attain the "balance" that the wizards of Earthsea keep striving for? How can we keep our nuclear dragons for burning all of us to cinders? What should we do with our dull and arrogant wizards who think they know more than anyone else?
Will we ever know if the universe is a soul or a machine? Maybe not. Like Ged in his little ship, the Lookfar, "we beat on, boats against the current, borne back ceaselessly into the past. (*)" It is our destiny to follow the great current that's taking us across the ocean of time to an unknown destination. Or maybe toward Earthsea.
(*) For those who live in Earthsea and may not have heard of "The Great Gatsby" by Scott Fitzgerald, that book is the origin of this quote.


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According to the latest issue of the Official PlayStation Magazine, the survival horror/first person shooter title Left 4 Dead is heading to the PlayStation 3 after all. In a one-liner, OPM states the following: "Valve's survival horror game Left 4 Dead is coming to PS3, but EA will be taking on development duties in-house."
No other information is given. All we are saying is, if EA wants us to give their port of Left 4 Dead a chance, it better be nothing like the "slideshow" version of the Orange Box that PS3 owners got.
[Via Joystiq]


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Court upholds conviction for 'poster child' of system failure
One of the youngest defendants in an infamous mob beating, and convicted of armed robbery soon after his release from his juvenile sentence, will remain in prison.
Artieas Y. Shanks was 13 when he took part in the fatal beating of Charlie Young Jr. in 2002. He was 20 when convicted of a 2006 armed robbery in 2009.
The state Court of Appeals on Tuesday has upheld Shanks' conviction. He was sentenced to 15 years, and on appeal challenged a detective's testimony about a line-up she conducted.
Shanks who escaped from a pretrial monitoring program while the armed robbery case wound its way through court, prompted Chief Edward Flynn to call him "the very definition of a menace to society."
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Supreme Court Tracker


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Recent Articles
Various Oahu Highlights
April 9, 2012 | Things to Do | Read MoreA rare flat rainbow over Waimea Bay
Sandy Beach is a favorite for bodyboarding
Volcanic mineral olivine makes sand sparkel green
Peaceful Kawele Bay is perfect for sunning and stand-up paddling
Chun's Beach is great for family time and surfing
View towards the Waianae Mountain Range
Tranquil sunset...
Back alley bread is a Moloka`i tradition
March 30, 2012 | Food | Read MoreJust a hop, skip and a jump away from bustling Honolulu is the polar opposite – the island of Moloka`i. The long and narrow island can be seen from the eastern shore of Oahu and can be reached for about $66 via airplane. If you make it to Moloka`i for some R&R from the busy streets of Honolulu,...
Calm Kawela Bay offers seclusion and ocean fun
March 27, 2012 | Things to Do | Read MoreKawela Bay is a hidden cove on Oahu's North Shore, which is likely to be a lot less crowded on any given day than most other beaches in the area. It's a large bay blanketed in fine white sand and backed by a thick forest of palms, banyan trees, and other dense foliage often explored by those on horse...
Locals say Oahu's Kahuku Superette makes the best poke island wide
February 1, 2012 | Food | Read MoreOn the east side of Oahu in a small town called Kahuku, not far from the North Shore is a small country market from which locals believe comes the best shoyu poke (a local appetizer of fresh tuna pronounced po-kay) on the island.
The small store, called the Kahuku Superette has been in business since...
January 31, 2012 12:07


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21 March 2017
They never piloted a B-17 Flying Fortress or manned the guns of a battleship. But their contribution to the war effort was a vital component to victory in the Second World War.
The Andrews Sisters already were a nationally known singing ensemble by the late 1930s. As the United States...read more


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follow us on 13 - 15 November 2018 // Nuremberg Exhibition Info Exhibition profile Exhibitors & Products Floor plan Media partners Industry links Travel Staying in Nuremberg Beviale Family Exhibitors & Products For Exhibitors Reasons for exhibiting Facts & figures Participation Exhibition marketing Exhibition presentation & services ExhibitorShop Services at the exhibition site Travel Hotels & Staying in Nuremberg FAQ Contact For Visitors Reasons for visiting Facts & figures Tickets Admission for visitors Services at the exhibition site Travel Hotels & Staying in Nuremberg FAQ Contact Review Press Press releases Media library Facts & figures Press subscription Accreditation Press services at the exhibition site Travel Hotels & Staying in Nuremberg Contact Contact Exhibitors Visitors Press International representatives
Posting print layout What information should be shown in the print layout? Product profile Exhibitor's products with product photos without product photos Hall / stand Product groups Create print layout You are here: Home | Exhibitor search Exhibitors & Products All Exhibitors All Products Product Groups Floor Plan Contact Exhibitors & Products All Exhibitors All Products Product Groups Floor Plan Contact Enter search term A product from: Sugherificio L.T.S. Srl Unionminale Zoom product MicroLTS tecnical cork MicroLTS tecnical cork Request information Contact us Please enter your personal information and desired appointment. You can also leave us a message. You haven't filled in all fields correctly. Please check your entries. Your personal information Mr / Ms* Please select... Mr Ms First name* Surname* E-mail* Phone Company* Your message for us Message Desired appointment during the exhibition Day Tuesday, 08.11.16 Wednesday, 09.11.16 Thursday, 10.11.16 Time 09 10 11 12 13 14 15 16 17 00 15 30 45 * Compulsory fields you must fill in. Send Your message has been sent. Would you like to use more facilities and advantages of the platform? Then please log in – or register here. An error has occurred. Hall 1 / 1-631 Add memo Your note Write a little note here... Write a little note here... Save memo Product description Exhibitor Profile Floor Plan Origin of cork Portugal, Spain Established in 1976 and located at the foot of Franciacorta - a strategic region for the winemaking industry - we specialize in the manufacture of corks for both still wine and the bubbly market. The company is run by Manlio Sordi and our mission is to manufacture highly reliable products, even at the low-cost end of the scale. The constant monitoring of all stages of production, from importing raw materials to after-sales support, led to LTS, in 2003, becoming the only Italian company to be awarded quality certification by the European Cork Confederation, following in the wake of two famous multinationals in the industry. Hall 1 / 1-631 Open floor plan Open floor plan Other products from Sugherificio L.T.S. Srl Unionminale Agglomerated cork Plasted cork Natural cork Cork of sparkling wine Notes There are no entries in your notes. Show notes


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7073. BoroDad17
Wow, 6Z GFS pushed a lot East. I know can't put any faith in one model run, but this has been a trend. Is the strengthening of Irene faster than anticipated, plus the lower anticipated land interaction causing this? I am also reading that the high is anticipated to be STRONGER, how does this jive with the further east tracks? |


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Golunski Leather Goods bring you this medium leather purse and is 14x9cm. Buy your ladies purse online now.
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English | ລາວ
Investment Promotion Zoning in Lao PDR
I. General Customs and Tax System and Fiscal Incentives
- Existing law on tax: Foreign (20%) and Domestic (35%).
- As of November 2011, the law on tax is in course of revising to unity the general profit tax for foreign and domestic investors. The new tax rate is speculated in the range of 24% - 28%.
- Minimum tax at the rate of 0.1% of total revenue.
- Personal income tax between 0% - 25% (progressive rate) after revising the law on tax.
- Fees and service charges.
According to Article 49 of the Investment Promotion Law (IP Law), the promoted sectors are agriculture, industry, handicraft and services. Details of promoted activities under the sectors are determined by the Government and classified into three different levels based on prioritized activities of the Government, the activities related to the poverty reduction, the improvement of living conditions of people, construction of infrastructure, human resource development, jobs creation, etc. The Government has established the following fiscal incentive systems:
1. Incentive or Corporate Profit Tax (Based article 50 and 51 of the IP Law)
Note: Refer to Investment Promotion Zoning Map
2. Specific Promotion Incentives (According to Article 54 of IP Law)
Investments in the construction of hospitals, kindergartens, schools, vocational schools, colleges, universities, research
centers and some public utilities shall obtain the exemption rental or land concession as follows:
3. Other Promotion Incentives (According to Article 52 of IP Law)
In addition to the profit tax incentives, investors shall be also entitled to customs duty and tax incentives, as follows:
1. Exemption from profit tax in the next accounting year, if the net profit derived from business activities is used for business expansion.
2. Exemption from import duties for the importation of raw material, equipment, spare parts and vehicles which are directly used for production. However, exemption of import tax shall comply with specific regulations.
3. Exemption from export duties for exportation of general goods and products. The exportation of natural resources and natural resources-made products shall comply with concerned regulations and laws. The importation of all types of fuel is not exempted from duties and taxes.
4. If an investor suffers losses after completion of tax finalization with the tax office, the investor shall be permitted to carry the losses forward to three consecutive accounting years. After ending of the period, any remaining losses shall not be allow to be deducted from profit. For special economic zones and specific economic zones, the provision of incentive treatment shall be in compliance with the Decree on the Establishment and Activities of respective zone.
Copyright © 2014 Investment Promotion Department, Vientiane Capital, Laos PDR


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All our students are engaged in the arts. At a minimum, they take one arts elective each year. But, the majority of our students are eager to sing, act, dance, play an instrument, get their hands dirty in pottery, and learn to work a video camera. Without a doubt, our arts classes and programs are among our most popular. There are specialized Centers of Excellence in strings and vocal music. And, there is so much more to explore.
Arts News at SSM
Arts Faculty


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New Music
The Archives
main attrakionz
Hear Tynethys' Smooth, Pulsing Slow Jam 'TFZ'
Playful Sacramento soulster Tynethys' open-hearted slow jam "TFZ" finds the Main Attrakionz collaborator shouting out his mom and dad for staying together. He also compares…
Brandon Soderberg
April 3, 2014
New Music
Rap Release of the Week: Ammbush's 'Ammbaataa'
There's not much information out there on Oakland producer-rapper Ammbush. He has made beats for DaVinci ("Champion," "Quit Playin'") and Main Attrakionz ("Wings"), and his…
Brandon Soderberg
April 9, 2013
New Music
No Trivia's Friday Five: Kanye West Bares His Soul, Shills for Smart Phone
Houston-based music writer and "tank-top enthusiast" Shea Serrano (read his excellent profile of No Trivia favorite B L A C K I E) and Houston…
Brandon Soderberg
October 26, 2012
New Music
Rap Release of the Week: Main Attrakionz's 'Bossalinis & Fooliyones'
Kendrick Lamar's good k.i.d. m.A.A.d. city is the best rap thing to come out this week. Hell, it's the best rap thing to out this…
Brandon Soderberg
October 25, 2012
New Music
No Trivia's Friday Five: Brick Squad's Ice Burgandy Is in Love With His Wallet
No Trivia Friday Five Reading List: Victor LaValle's The Devil In Silver. It's like Ken Kesey's One Flew Over the Cuckoo's Nest, if you sent…
Brandon Soderberg
October 19, 2012
Main Attrakionz, 'Bossalinis & Fooliyones' (Young One)
"If we could record every day, we would," the rapper Mondre M.A.N. told The Fader late last year. Since July 2011, he and his partner…
Mike Powell
October 15, 2012
New Music
No Trivia's Friday Five: Beanie Sigel Auditions to Star as Willie in 'ALF' Reboot
News flash: Clint Eastwood has always been a big jerk! He starred in some of the creepiest, most conservative movies ever made, too many of…
Brandon Soderberg
August 31, 2012
Santigold, Big K.R.I.T., Best Coast Deep-Fry SPIN's Austin BBQ
After Escort finished their set on the main stage at Stubb's, the afternoon's host, comic DC Pierson, commended the 17-piece disco army on having the…
Steve Kandell
March 17, 2012
Santigold, Best Coast, Big K.R.I.T. Set for SPIN's Austin Throwdown
SPIN is proud to announce the complete lineup of our 2012 party in Austin, set for Friday, March 16. Once again at the city's fingerlickingest…
SPIN Staff
March 1, 2012
New Music
First Spin: Main Attrakionz's Collaborative EP 'cLOUDLIFE'
On cLOUDLIFE's opening track "Chap 3," Squadda B briefly croons Jim Jones' hook for Cam'ron's "The Dopeman," and the song's whole conceit is pretty much…
Brandon Soderberg
February 28, 2012
Hear Main Attrakionz Team Up With Danny Brown and G-Side
On "Suffocation," MondreMAN, one-half of the self-proclaimed "Greatest Duo Ever" — Oakland cloud rap weedheads Main Attrakionz — gets laced with a floating, hazy jam…
SPIN Staff
December 8, 2011
Rap's New Underground: Meet Cities Aviv and Main Attrakionz
In our December issue, contributing writer Brandon Soderberg explored dozens of acts that comprise hip-hop's new underground, including Cities Aviv, an arty loner from Memphis…
SPIN Staff
December 5, 2011
26 Photos
SPIN's All-Access Pass to CMJ 2011: Photos From Backstage to the Front Row
Ken Bachor
October 24, 2011
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Tuesday, March 5, 2013
BelindaPalooza Day Six! Belle Starr!
8 comments:
- ayliss72 said...
I'd love to read this story :-) WEREWOLF in the space! Siberians are special I had one for 15 years, Lucrezia, so stubborn and smart, I loved her very much.
Cinia - March 6, 2013 at 10:46 AM
- ayliss72 said...
Sorry I forgot to leave my email address
firstname.lastname@example.com - March 6, 2013 at 10:48 AM
- ilona said...
I love shape shifter stories, I LOVE Science Fiction and you have put them together? I WANT!!
felinewyvern at googlemail dot com - March 6, 2013 at 10:51 AM
- joder said...
I'm a huge fan of sci-fi and the intriguing world's created! I LOVE the sound of this book and ssssooooo hope to win a copy!
joderjo402 AT gmail DOT com - March 6, 2013 at 2:54 PM
Cool cover
bn100candg(at)hotmail(dot)com - March 6, 2013 at 6:25 PM
- dnjrus2 said...
space ships werewolf sounds like fun so i am thinking you really can't hide
- March 7, 2013 at 2:21 AM
This is one of my fav books to re-read. I hope there will be another book in the series
- March 7, 2013 at 2:27 AM
- flchen1 said...
I think I missed this one--adding to my TBB, Belinda!
f dot chen at comcast dot net - March 9, 2013 at 7:57 PM


text:
Lemmings Credits (SAM Coupé)
Published by Developed by Released Also For |
Critic Score
100 point score based on reviews from various critics. ...
User Score
5 point score based on user ratings. |
Lemmings Credits
Credits | |
Lemmings by | DMA Design |
Brought to SAM | FRED Publishing |
Licensed from | Psygnosis Ltd |
SAM Programming | Chris J. White |
Grafix Converted | Neil Holmes |
Extra Grafix | Doug Holmes |
Music | Craig Turberfield |
Other Games
In addition to this game, the following people are listed as working on other games. No more than 25 people are listed here, even if there are more than 25 people who have also worked on other games.
Neil Holmes, 26 other games
Doug Holmes, 6 other games
Credits for this game were contributed by Kabushi (172752)


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Great Spells in Newark, NJ
Welcome! My name is Phelan, I am a psychic, witch practitioner and root worker located in Atlanta, GA. I specialize in performing white witchcraft rituals customized to all my client's needs. You may call me at 678-918-3333 or create an account if you have questions about phone psychic readings, consultations in person or psychic readings via email or if you are interested in Great Spells. Even though I am physically located in Atlanta I can bring positive and magical change to you in Newark, NJ, magic knows no boundaries!
I also work with clients who have been cursed or hexed, the damage created by negative magic against them causes enormous physical, emotional, mental and spiritual pain. To overcome the difficulties brought upon black magic is a great challenge, but it is not impossible.
As a white witch I use many different spells and rituals to aid my clients in their time of need, contact me today to get the ethical help that you need to solve your complex problem.
I look forward to working with and aiding you in effecting the positive change within your life that you desire, need and deserve!
Blessed Be, Phelan
Great Spells | Gay Male Wiccan | Newark, NJ


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The notion and understanding of law penetrated society in Ancient Rome to a degree unparalleled in modern times. The poet Juvenal, for instance, described the virtuous man as a good soldier, faithful guardian, incorruptible judge and honest witness.This book is concerned with four central questions: Who made the law? Where did a Roman go to discover what the law was? How has the law survived to be known to us today? And what procedures were there for putting the law into effect? In The Sources of Roman Law, the origins of law and their relative weight are described in the light of developing Roman history. This is a topic that appeals to a wide range of readers: the law student will find illumination for the study of the substantive law; the student of history will be guided into an appreciation of what Roman law means as well as its value for the understanding and interpretation of Roman history. Both will find invaluable the description of how the sources have survived to inform our legal system and pose their problems for us.
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text:
Harriet Walter: Redressing the Balance - Gender in Shakespeare
With recent productions of King Lear at the Old Vic, the Donmar's trilogy of The Tempest, Henry IV and Julius Caesar, and the National Theatre's Twelfth Night in mind, a panel questions the reasons for, and challenges of, swapping the gender for some of Shakespeare's key roles, and whether this makes them more relevant or accessible for today's audience. What can an actress bring to these roles – and is there any fundamental difference in the way they must be played?
Guests include Harriet Walter, whose new book, Brutus and Other Heroines, is an exploration of the Shakespearean canon through the eyes of 'a self-identified feminist actor', as she describes herself.
Harriet Walter will be signing copies of her book, Brutus and Other Heroines, after the Platform.
Friday 31 March, 6pm
Running Time: 45 minutes approximately
Tickets £5 (£4 concessions) from www.nationaltheatre.org.uk/shows/redressing-balance-gender-shakespeare
Brutus and Other Heroines - Playing Shakespeare's Roles for Women
Harriet Walter
Date: Friday 31st March 2017 6.00pm
Location: National Theatre, London


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Good morning dear friends,,,, this is the sweet view from my kitchen window....
and this is the view as I walked around the house this morning... sorry the photos are not real clear, I was out taking photos at 7:30 when the morning light was uber bright!..
It was such a nice morning until
Aacckkkk! we had a Deer attack! Darn it! How can such a sweet looking creature evoke such anger and frustration in a human? I was almost thinking,,, Venison for dinner wouldn't be so bad! lol!
let's see.. they chowed down on 2 of my sunflowers,,,,
ate all the leaves around the plums, and the birds are doing their damage to the plums that the deer haven't eaten... Seriously Birds??? ya gotta peck at each plum? can't you just eat 1 whole plum???
one of my sweet roses,,,, yes they got to all of them, this was the worst of the rose damage...
my darling Hibiscus is now only a foot tall of branches...
and this is what the rest of my roses look like...
So... I have lived in the 'Burbs"... no gophers, ground squirrels no raccoons and no deer!
I have lived on the West Plains (wheat farm land) of Eastern Washington... where I learned that gophers, ground squirrels and deer will desimate a garden over night... so hubby built me a 20 X 30 garden with a 6ft tall fence around it... And I did container gardening... haha! stick that in your pipe and smoke it you little vermants!
Now I live in the mountains of Central California and I get to add raccoons to my list of most hated!
I see a totally fenced in garden next year.... yet another 'Honey-do' project for my dear hubby.
Oh and did I mention the deer stripped my almonds trees bare? Yep!
So I have 2 options,,,, hit a Martini Bar and drown my Garden sorrows... or,,, deer, raccoon and rodent proof my garden for next year! ... hmmmm, thinking, thinking... lol!
So, How was Your morning?


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Old fart Frankie feed teen Amy his beef jerky
Description: horny frankie got her old cock suck by teen amy giving him a steaming deep throat blowjob frankie enjoys it as his matured beef jerky getting swallow although he will not be a part of the short film that amy and glenn is going to do
Duration: 06:30
Categories:boysfood teen old+man teens teen+anal amy+poehler+sex asian+teen young+teen teen+creampie ebony+teen milf+and+teen old+and+young blonde+teen
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Green River Festival!
Mike's Maze is proud to support our community, and great music! We are the sponsor the Art Garden Children's Area at the Green River Festival. We will also have our own mini hay bale maze for the kids to enjoy. If you saw us there, don't forget to bring your coupon from our booth to the maze for your special offer.
Group Discount!
We offer $1 off general admission rates for Groups of 15 or more. Gather at the maze entrance, pool your cash and pay at the admissions booth.
Win a Cider Donut!
Try your hand at the Potato Blasters. Hit the "donut" target and win a free freshly made cider donut. (offer good during daytime only)
More Offers throughout the year!
Throughout the season we may offer discounts on certain items. Please check back for printable coupons!


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Bibliographic record and links to related information available from the Library of Congress catalog
Information from electronic data provided by the publisher. May be incomplete or contain other coding.
Preface 1. Introduction 2. Lagrangians and fields 3. Topology in field theory 4. Solitons: general theory 5. Kinks 6. Lumps and rational maps 7. Vortices 8. Monopoles 9. Skyrmions 10. Instantons 11. Saddle points: sphalerons References Index.


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By Boyce Thompson. My wife and I can't believe what the house down the street just went for. Granted, it's in a great location, close to the city, and within a fine school district. But, boy, did they pay a lot of money. And to think that our house is worth nearly just as much!
I'm sure a lot of you have had the same experience lately. Word travels quickly through the neighborhood when everyone's biggest asset takes a quantum leap in appreciation. The government reports that through March, year over year, the value of new and existing homes is up about 6.5 percent. In many places, the numbers are even higher.
Six and a half percent is a lot better than my 401(k) plan did during that period--a lot better. And it's better than my mutual fund did. It's too bad I didn't take some of that money out a couple years ago to buy an investment property. I probably could have paid for a couple years of college tuition for my kids with the proceeds.
When opportunity knocks
The more financially nimble of us have no doubt taken advantage of opportunities like that. You see the signs occasionally--customers paying all cash or taking an early position on a home in a new master plan, renting it for two years, then selling the home after its value has gone up $30,000. Speculation is back in the market, though it's by no means rampant. If it were, the Fed probably wouldn't have decided to leave interest rates untouched last month.
Make no mistake--housing is a great investment. Frank Raines, the chairman and CEO of Fannie Mae, presented numerical testimony to that fact in a recent speech at the National Press Club. He asked everyone to look back to 1990 and imagine that they had just received a $10,000 year-end bonus. Where should they put it?
Photo: Jo Lance
The conservative choice would be an index of SP 500 stocks. A more aggressive choice would be to invest in high-technology stocks through a NASDAQ index fund. The final choice he presented was making a down payment on an $80,000 bungalow. The results
Now it's 12 years later. Which investment did better, assuming in each case you still had to pay for shelter? The value of the SP 500 more than tripled, so from this initial investment you could have made $22,000, pre-tax. The value of the NASDAQ quadrupled during this period, producing a $30,000 pre-tax gain.
Appreciation in home values may not have made the headlines that the stock market did during the last 12 years but it provided some nice returns--4 percent per year nationally. Which means that $80,000 home would be worth about $126,000 now. And if you sold it, the $46,000 gain would be free of capital gains taxes. Housing, of all things, produced the best return.
As builders, you shouldn't lose sight of the fact that you build wealth for Americans. Chances are that your buyers during the last 12 years made more money on that investment than they did on the stock market. And think of all the tax revenue they generated for the government. Mention that next time you are asked to defend your plans for a new community at a county board meeting.
e-mail: firstname.lastname@example.com


text: The PV 10 AT shares all of the features of the PV 10 BT but also features 2 channels of Antares world-famous Autotune for subtle pitch correction or to create a robotic vocal effect. Other features include 4 channels of reference-quality mic preamps with 48 volt phantom power, 4 direct outputs for recording, full featured stereo channel and media channels with Bluetooth wireless input allows seamless connection to almost any 'smart' device, high quality digital effects with LCD display. Channels have 3-band EQ per with bypass, exclusive Mid-Morph EQ on the mic channels, switchable high-pass filter, channel mute buttons, channel solo, aux send, signal clip indicators, 2 channels of compression, on board selectable guitar preamp with 1 Meg Ohm Hi-Z preamp and special guitar EQ curve. Streaming USB out with USB return to mains and or control room., MP3 file playback via USB A input, Peavey's exclusive Kosmos audio enhancement, dual selectable control room outputs, and a stereo master LED meter bridge, 60mm master faders and XLR main and monitor outputs. Peavey PV 10 AT Mixer with Auto-Tune Features


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Located in Wailua within a short walk of Wailua River State Park, CRH - Wailua Bay View is within a mile (2 km) of Smith Family Garden Luau. This 45-room, 3-star condo property has an outdoor pool along with free in-room WiFi and free self parking. It's on the beach and also near Lydgate Beach Park and Smith's Tropical Paradise.
The 45 individually decorated condos feature kitchens and lanais. There's space to spread out with separate bedrooms, living rooms, and dining areas. Guests can enjoy free WiFi and cable TV. Bathrooms offer hair dryers and free toiletries. Washers/dryers, coffee makers, and free local calls are other standard amenities.
Property features
Guests staying at CRH - Wailua Bay View enjoy an outdoor pool, free WiFi in public areas, and barbecue grills. You can put free parking to good use if you drive.
- Free WiFi in rooms and public areas
- Free parking
- Outdoor pool
CRH - Wailua Bay View
Condo Amenities
Condo Amenities
CRH - Wailua Bay View features an outdoor pool and barbecue grills. High-speed wireless Internet access is complimentary. Complimentary self parking is available on site.
CRH - Wailua Bay View is a smoke-free property.
- Total number of rooms - 45
- Number of floors - 3
- Barbecue grill(s)
- Free WiFi
- Year Built 1978
- Free self parking
- Smoke-free property
- Number of buildings/towers - 1
- Outdoor pool
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Separate living room
- Free Wi-Fi
- Kitchen
- Separate dining area
- Washer/dryer
- Refrigerator
- Microwave
- DVD player
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
CRH - Wailua Bay View offers 45 air-conditioned accommodations, which are accessible via exterior corridors and feature washers/dryers and DVD players. Rooms open to lanais. These individually decorated and furnished accommodations have separate living rooms. Televisions come with cable channels. Accommodations at this 3-star condo have kitchens with refrigerators, stovetops, microwaves, and separate dining areas. Bathrooms include bathtubs or showers, complimentary toiletries, and hair dryers.
This Kapaa condo provides complimentary wireless high-speed Internet access. Business-friendly amenities include safes and phones; free local calls are provided (restrictions may apply). Additionally, rooms include coffee/tea makers and irons/ironing boards.
- DVD player
- Lanai
- Air conditioning
- Ceiling fan
- Access via exterior corridors
- Phone
- Free local calls
- Microwave
- Kitchen
- Refrigerator
- Coffee/tea maker
- Private bathroom
- Free toiletries
- Hair dryer
- Bathtub or shower
- Iron/ironing board
- In-room safe
- Oven
- Separate living room
- Cookware, dishware, and utensils
- Washer/dryer
- Separate dining area
- Dishwasher
- Stovetop
- Cable TV service
- Free WiFi
- Separate bedroom
- Individually furnished
- Individually decorated
Nearby Things to Do
Recreational amenities at the condo include an outdoor pool.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Surfing/boogie boarding nearby
- Kayaking nearby
- Sailing nearby
- Scuba diving nearby
- Windsurfing nearby
- Rafting nearby
- Scooter/moped rentals nearby
- Hiking/biking trails nearby
- Mountain biking nearby
- Ecotours nearby
- Golf lessons available nearby
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
Condo Policies
Check-in time ends at 2 AM
Check-in time starts at 3 PM
Minimum check-in age is 21
Special check-in instructions:
Check-out time is 10 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! One child 17 years old or younger stays free when using existing bedding.
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
No cribs (infant beds) available
No elevators
- Cleaning fee: USD 110 per accommodation, per stay
Condo Name
- CRH Bay View
- CRH Bay View Condo
- CRH Bay View Condo Wailua
- CRH Wailua Bay View
We should mention
One child 17 years old or younger stays free when occupying the parent or guardian's room, using existing bedding.


text: Home > Business After electricity and fuel, water rates also to rise ABS-CBN News Posted at Jul 16 2012 04:55 PM | Updated as of Jul 17 2012 05:24 PM Share Save Facebook Twitter GPlus LinkedIn Pinterest MANILA, Philippines -- Starting September, residents of Metro Manila and nearby provinces will also have to gear for an increase in water rates. The Metropolitan Waterworks and Sewerage System (MWSS) has approved the foreign currency differential adjustments of its water concessionaires, Manila Water Co. and Maynilad Water Services Inc. In the east-zone, Manila Water will increase by P4 the bills of those using 20 cubic meters and P9 for those using 30 cubic meters. For the west zone, the average rate hike is P0.89 per cubic meter. This means that those consuming 20 cubic meters per month will see an increase of P19 in their September bills. Those consuming 30 cubic meters, on the other hand, will see their bills rise by P27.95. Maynilad said its adjustments also reflected the removal of the P1 per cubic meter discount on the tariff. It said, however, that its lifeline users need not worry. "Due to the improved economic conditions, we will also limit our voluntary discount of one peso per cubic meter of water consumed to our lifeline customers, or those whose monthly water consumption is 10 cubic meters or less," Maynilad said. The west-zone concessionaire said the water bill of lifeline customers will decrease by P0.27 or from P107.19 to P106.92. - by Alvin Elchico, ABS-CBN News Share Save Facebook Share on Twitter GPlus LinkedIn Pinterest Read More: Maynilad Manila Water mwss water rates /news/03/30/17/3-trak-motorsiklo-sinunog-sa-general-santos/news/03/30/17/high-ranking-cop-arrested-in-alleged-las-pias-drug-session/business/03/30/17/philippines-submits-more-projects-for-japanese-funding/news/03/30/17/jinggoy-seeks-furlough-to-attend-eraps-80th-birthday/news/03/30/17/lover-boy-kawatan-nahaharap-sa-maraming-kaso