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13 August 2013 - Amsterdam: CPhI and UBM live, today announced that this year's recent CPhI China 2013, which took place on 25th-27th June at the Shanghai New International Expo Centre, was the most successful exhibition to date.
Attendance rates far exceeded expectation and CPhI and P-MEC China, alongside co-located events BioPh, ICSE, InnoPack, hosted a record breaking more than 2,400 companies both local and international and attracted more than 30,000 visitors from 133 countries throughout the world.
The 13th consecutive event was the foremost meeting point and networking opportunity for senior Chinese pharma professionals and international pharmaceutical suppliers and buyers.
In response to the implementation of China's 'five year plan', CPhI China 2013 saw a strong focus on research and development with LABWorld, BioPharma and ICSE all contained in one hall, mirroring China's continued commitment to this area and reflecting its exemplary position in the pharmaceutical world.
R&D investments in China have been at a high throughout 2013- it has been estimated that growth in investment within this area matches that of the USA. The [12th] 'Five-Year Plan', implemented by the Chinese government targets pharmaceutical R&D as a key initiative, with financial and beneficial incentives being offered in order to encourage R&D activities within the country. These include exemption from import customs duty on R&D equipment and a reduced income tax rate. In light of this, the R&D focus at CPhI China 2013 provided an informative update on the efforts being made by the government in facilitating innovation within the country.
On-site at CPhI China 2013, the "China and World" Medical Forum proved highly insightful and valuable for attendees. Having received substantial support from a vibrant speaker team of government and leading pharmaceutical companies, the forum showcased hot topic seminars and conferences. These covered the latest policies and regulations within the pharmaceutical industry and the practical applications of new technology. Furthermore, the Buyer Sourcing Event, with more than 60 buyers, 280 sessions and over 90% successful match rate, has provided a catalyst for increased business connections in the region.
Chris Kilbee, CPhI Pharma Group Director at UBM Live commented, "The Chinese pharmaceutical industry is now the third largest in the world and is ever growing -- it is predicted to expand at the annual rate of 12% from 2013 to 2020. Having witnessed a shift in focus to R&D by China, CPhI China 2013 was designed to reflect these widespread changes. The event was undoubtedly a success for both UBM Live, CCMHPIE and our attendees and, consequently, over 40% of exhibitors present have already registered for next year. This result show that CPhI China is now at the centre of pharmaceutical business connections within the region".
CPhI 2014 will return alongside co-located events ICSE, BioPh, P-MEC, InnoPack and Labworld, on 26th -28th June, 2014 at the Shanghai New International Expo Centre. The exhibition will increase its scale and, reiterating the importance of R&D in China as CPhI China 2014 will focus on biopharmaceutical R&D with 'BioPh China' and 'ICSE China' making up an integral part of the exhibition. A further main focus for next year will be natural extracts in which exhibiting companies will occupy more than one hall.
The UBM Live annual schedule of Pharmaceutical events also includes CPhI Worldwide, ICSE, P-MEC Europe and InnoPack (22-24 October, 2013 at Messe Frankfurt, Germany); CPhI and P-MEC India (03-05 December, 2013 at the Bombay Exhibition Centre in Mumbai); CPhI, ICSE, P-MEC, BioPh and Pharmatec Japan (9-11 April, 2014 in Tokyo); CPhI Russia and IPhEB (16-17 April, 2014 in St Petersburg, Russia); CPhI, P-MEC and Innopack South East Asia (20-22 May, 2014 in Jakarta, Indonesia); CPhI Istanbul (4-6 June, 2014, Turkey).
The UBM Live annual schedule of Pharmaceutical events also includes CPhI, ICSE and BioPh South America (06-08 August, 2013 at the Expo Center Norte in Sao Paulo, Brazil); CPhI Worldwide, ICSE, P-MEC Europe and InnoPack (22-24 October, 2012 at Messe Frankfurt, Germany; CPhI and P-MEC India (03-05 December, 2013 at the Bombay Exhibition Centre in Mumbai); CPhI, ICSE, P-MEC, BioPh and Pharmatec Japan (9-11 April, 2014 in Tokyo); CPhI Russia and IPhEB (16-17 April, 2014); CPhI, P-MEC and Innopack SE Asia (20-22 May, 2014 in Jakarta, Indonesia); CPhI, P-MEC, ISCE, InnoPack Istanbul (4-6 June 1014 in Istanbul) CPhI, P-MEC, ICSE, InnoPack and BioPh China (26-28 June 2014 in Shaghai).
About CPhI
CPhI drives growth and innovation at every step of the global pharmaceutical supply chain from drug discovery to finished dosage. Through exhibitions, conferences and online communities, CPhI brings together more than 100,000 pharmaceutical professionals each year to network, identify business opportunities and expand the global market. CPhI hosts events in Europe, China, India, Japan, Southeast Asia, Russia and South America co-located with ICSE for contract services, P-MEC for machinery, equipment & technology, InnoPack for pharmaceutical packaging and BioPh for biopharma. CPhI provides an online buyer & supplier directory at CPhI-Online.com and hosts a global community with news and analysis at PharmaEvolution.com.
For more information visit: www.cphi.com
About UBM Live
UBM Live connects people and creates opportunities for companies across five continents to develop new business, meet customers, launch new products, promote their brands, and expand their market. Through premier brands such as TFM&A, Internet World, IFSEC, MD&M, CPhI, Cruise Shipping Miami, the Concrete Show, and many others, UBM Live exhibitions, conferences, awards programs, publications, Websites, and training and certification programs are an integral part of the marketing plans of companies across more than 20 industry sectors.
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Tea Party Leader Hopes Five Supreme Court Justices Get Colon Cancer
…said Thursday in a Facebook post reacting to the Supreme Court ruling on health care, "I hope the (5 supremes) get colon cancer."
A day after posting the message, Malzone said he stands by what he said. He clarified that he doesn't want anyone to die, and the cancer reference was more to make a point that he wants them to feel the pain being inflicted on Americans being overburdened by taxes.
"I didn't wish for anyone to die, but I said I do wish for them to feel our pain," he said. "No one cares about me, they all make their promises and then go do what they goddamn feel."
…Malzone later apologized for his heated rhetoric, saying in part, "I can't believe how angry I was. But it is what it is. I apologized to Merrimack Tea followers for my language."
Click here for reuse options!Copyright 2012 Liberaland

subset: commoncrawl


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Goose at Sunset
by pathseeker
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Artist | pathseeker |
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License |
A lone Canada Goose swims in the twilight on Centennial Lake in Howard County, MD. Photos used by permission of http://flyaway.smugmug.com/ .
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Table Of Contents
Affiliated Foods Inc. - Strategy and SWOT Report
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IT World Canada has recently published an interesting "Disband the ITU's IPv6 Group, says expert" article. I can't agree more with the title or the first message of the article: there is no reason for the IPv6 ITU group to exist. However, as my long-time readers know, that's old news ... and the article is unfortunately so full of technical misinformation and myths and that I hardly know where to begin. Trying to be constructive, let's start with the points I agree with.
IPv6 was designed to meet the operational needs that existed 20 years ago. Absolutely true. See my IPv6 myths for more details.
ITU-T has spun up two groups that are needlessly consuming international institutional resources. Absolutely in agreement (but still old news). I also deeply agree with all the subsequent remarks about ITU-T and needless politics (not to mention the dire need of most of ITU-T to find some reason to continue existing). That part of the article should become a required reading for any standardization body.
And now for (some of) the blunders:
IPv6 was a geek response to IAB's adoption of CLNP. First of all, I don't remember IAB every adopting CLNP. It did adopt IS-IS (which is the routing protocol used by CLNP) – an excellent decision that resulted in the only standardized multi-protocol IGP available today (that's why all Shortest Path Bridging proposals including TRILL and 802.1aq use IS-IS). I can only hope that the loss of distinction between IS-IS and CLNP was a result of the editorial process, not a statement by the author (in which case I would have to start doubting his expertise).
Next, one of the proposals for next-generation IP (TUBA – TCP and UDP over Big Addresses) was indeed based on CLNP, but it was decided to move forward in a way that was more familiar to the IP world (as you know, regardless of window dressing, IPv6 is really IPv4 with minor fixes and longer addresses).
To put my statements in perspective: I was a devote supporter of TUBA and was deeply disappointed when IETF decided to reinvent the wheel instead of using a protocol that was already available, implemented by numerous vendors and field-tested. However, with 20 years of layer 8-10 experience behind me, I can understand that the totally different routing paradigm of CLNP and its variable-length addresses scared the IP gurus ... and it's always nicer to reinvent the wheel and get the credit for the shiny new toy than to adopt someone else's work.
Last, I wouldn't use a pop book that was published 15 years after the events as a reliable source. When I was stupid enough to believe an "expert" who explained in vivid details what a catastrophe FTP is, numerous readers pointed out that FTP was, in fact, a well designed tool for the job it was supposed to be solving.
When IPv6 was finally adopted, many in industry made it clear they were not going to use the protocol. Of course, what else would you expect? It was much simpler to create private IP addresses and add NAT on top of IPv4 (all of which was solved within the network layer) than to wait for the rest of the IT industry to implement new protocol stack on all the hosts, persuade all the developers to change the way they open sockets (using the broken API) and fix all the outstanding applications. It took OS vendors more than a decade to finally implement IPv6 properly and several more years for the off-the-shelf applications to become reasonably IPv6-aware. Who knows what's lurking in hidden depths of home-baked enterprise code?
After 16 years of evangelization, the "father of the Australian Internet," Geoff Huston, who became tired of the endless IPv6 hype, demonstrated in 2008 that only 0.4 per cent of the TCP/IP traffic was IPv6. What else would you expect? See above. And, just as an aside, if someone would truly invest 16 years in evangelizing IPv6, we might have seen some results. The sad fact was that IPv6 was largely forgotten after everyone implemented RFC 1918 and NAT.
Governments ... seem obsessed with continuing to drive IPv6 as some kind of panacea. It would be really good to hear from the same self-professed expert what his solution to the IPv4 public address depletion is. Carrier-grade NAT? CLNP? X.25?
Unfortunately, those few government agencies that can see beyond the next elections had to start the IPv6 push because the whole IT industry focused on quarterly results was in a state of denial (not dissimilar to the car industry's handling of global warming). Without the government-sponsored push, there would be little (if any) IPv6 deployment today and we would be even more unprepared for the IPv4 address depletion.
20 years ago governments pushed CLNP because everyone believed it was the right protocol (IP was a geek toy). History proved them wrong. Lesson learned: don't trust a protocol designed by a committee? Now they are pushing IPv6 because the only alternative is the breakdown of the end-to-end Internet.
LISP ... provides a compelling direction that IPv4 or IPv6 lack. LISP is a necessary hack because we can't change what should truly be changed: the end hosts. I like LISP and the approach it takes to solving multi-homing and traffic engineering problems, but all those problems wouldn't exist if someone would have taken the time to fix the broken TCP/IP architecture. What we're doing today is introducing another layer of indirection at the network layer because we can't change the things that are really broken.
A trusted implementation of LISP will provide a level of attribution and routing security that does not exist in the present architecture. Wishful dreams. To start with, LISP relies on underlying IPv4 or IPv6 global transport, which will be still implemented with current tools (BGP) and will thus stay as "secure" as it is today. Second, if we would be truly interested in routing security, we could have implemented secure BGP a long time ago, but it didn't happen for a simple reason: those people that would benefit from it (content providers) were in no rush to pay those people that would have to implement it (ISPs).
To give you another example: it took almost a decade to develop and implement DNSSEC, even though we've experienced some very interesting DNS-based attacks in the meantime. Why would LISP be any different?


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- Description
Meet the new instrument plug-in powerhouse for your studio. Inspired by legendary subtractive synthesizers, MX4 combines several core synthesis techniques in a unified, hybrid synthesis engine that delivers fresh and vintage sounds alike.
As you explore its many banks and hundreds of presets, you'll soon rely on MX4 as your "go-to" instrument. Fat basses, nasty leads, analog pads, vintage electronica — it's all at your fingertips and conveniently saved with your host application projects for instant recall.
Tweaking sounds is fast and easy with clearly presented controls in one window — but with a depth and sophistication true synth programmers will appreciate. Create your music with pristine 32-bit sound quality, unlimited voices and unlimited polyphony (as much as your host computer allows). MX4's flexible programming and advanced modulation architecture provide the intimacy of a vintage synth, the flexibility of a modular synth, and the innovation of a virtual synth.
- Technical Specifications
Additional Information
Condition New Software Delivery Retail Box Virtual Instrument Type Pianos and Keyboards Plug-In Format RTAS, AU Operating System Mac, Windows - Reviews
- Testimonials


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Irina, ID: 3546887
Age: | 29 |
City: | Kiev |
Country: | Ukraine |
Zodiac: | Scorpio |
Height: | 5' 9'' (175 cm) |
Weight: | 121 lbs (55 kg) |
Eyes: | green |
Hair: | brown |
Occupation: | Civil Engineer |
Education: | college |
Religion: | Orthodoxy |
Marital Status: | never married |
Kids: | 0 |
Languages Spoken: | English, Russian |
English Proficiency: | intermediate |
Smoking: | no |
I love reading books. Russian literature is very interesting to me, I've read many books and have even tried writing my own, however this is where my mind stops working and I can't think of anything. And of course I have an obsession for collecting shoes, after all I am a girl!
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Looking For An Age Group28 - 57


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text:
The Full Nexus One Specifications Cheat Sheet
- 7
The date was near, now it is here, so what is this new phone indeed? The Nexus One, what Google calls a "superphone," does have some pretty darn fine specifications.
Below, the full condensed list for your viewing, and drooling, pleasure. Also, drop a comment on whether or not you are going to pick one up. If you cannot in your nation, I do offer my condolences. To the list!
"We're hunting for awesome startups"
Run an early-stage company? We're inviting 250 to exhibit at TNW Conference and pitch on stage!
Size & Weight:
Height: 119mm
Width: 59.8mm
Depth: 11.5mm
Weight: 130 grams with battery, 100g without battery
3.7-inch (diagonal) widescreen WVGA AMOLED touchscreen
800 x 480 pixels
100,000:1 typical contrast ratio
1ms typical response rate
Camera and Flash:
5 megapixels
Autofocus from 6cm to infinity
2X digital zoom
LED flash
User can include location of photos from phone's AGPS receiver
Video captured at 720×480 pixels at 20 frames per second or higher, depending on lighting conditions
Cellular and Wireless:
UMTS Band 1/4/8 (2100/AWS/900)
HSDPA 7.2Mbps
HSUPA 2Mbps
GSM/EDGE (850, 900, 1800, 1900 MHz)
Wi-Fi (802.11b/g/n)
Bluetooth 2.1 + EDR
A2DP stereo Bluetooth
Power and Battery:
Removable 1400 mAH battery
Charges at 480mA from USB, at 980mA from supplied charger
Talk time:
Up to 10 hours on 2G
Up to 7 hours on 3G
Standby time:
Up to 290 hours on 2G Up to 250 hours on 3G
Internet use:
Up to 5 hours on 3G
Up to 6.5 hours on Wi-Fi
Video playback:
Up to 7 hours
Audio playback:
Up to 20 hours
Qualcomm QSD 8250 running at 1 GHz
Operating System:
Android Mobile Technology Platform 2.1
512MB Flash
4GB Micro SD Card (Expandable to 32 GB)
Assisted global positioning system (AGPS) receiver
Cell tower and Wi-Fi positioning
Digital compass, Accelerometer
Additional Features:
Haptic feedback
Teflon™ coated back
Second microphone for active noise cancellation
SIM card slot
Micro SD slot
Proximity sensor
Light sensor
Pre-Loaded Applications:
Maps, Gallery, YouTube, Market, Phone, Gmail, Browser, Voice, integrated Google suite, Navigation, and others. No full official list available at this time.
File Formats Supported:
Image: JPEG (encode and decode), GIF, PNG, BMP
Video: H.263 (encode and decode) MPEG-4 SP (encode and decode) H.264 AVC (decode)
Audio encoders: AMR-NB 4.75 to 12.2 kbps sampled @ 8kHz
Audio decoders: AAC LC/LTP, HE-AACv1 (AAC+), HE-AACv2 (enhanced AAC+) Mono/Stereo standard bit rates up to 160 kbps and sampling rates from 8 to 48kHz, AMR-NB 4.75 to 12.2 kbps sampled @ 8kHz, AMR-WB 9 rates from 6.60 kbit/s to 23.85 kbit/s sampled @ 16kHz., MP3 Mono/Stereo 8-320Kbps constant (CBR) or variable bit-rate (VBR), MIDI SMF (Type 0 and 1), DLS Version 1 and 2, XMF/Mobile XMF, RTTTL/RTX, OTA, iMelody, Ogg Vorbis, WAVE (8-bit and 16-bit PCM)
Languages Supported:
Keyboard: English (U.S), French (France), German, Italian, Spanish, Portuguese (Brazil)
Display: English (U.S), French (France), German, Traditional Chinese, Simplified Chinese, Italian, Spanish, Portuguese (Brazil), Korean, Japanese, Russian,
Read next: 3 billion iPhone apps downloaded in just eighteen months.


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Our workshops are a great method for creating a work area on your residential or commercial property. If you've got an area you need to add to production, or an idea awaiting your construction our workshops are a perfect fit. They come in a wide variety of sizes, from small woodworking shops, to large commercial buildings that could be used for assembly lines. We make the work easy as well, as all our buildings have free installation and delivery. If you're shopping for a workshop, Elephant Structures has got you covered with the best metal structures in the business.
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Lots of mushroom hunting lately - even the squirrels have been busy. Did you know that they will pick and dry mushrooms for the winter? Well they do. One year a dear friend and I went out to a cabin he had built (in Alaska) and had been away from for a year due to hip surgery. We went in spring and when we went to check out the outhouse we found it piled three feet high with dried mushrooms!
08 September 2008
5 comments:
- AnonymousMon Sep 15, 03:51:00 AM AKDT
I did know that those critter stock up on mushrooms. I grew up in the sticks, so you get to know that kind of stuff. :)
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What does UCSD mean in Universities?
This page is about the meanings of the acronym/abbreviation/shorthand UCSD in the Academic & Science field in general and in the Universities terminology in particular.
University of California, San Diego
Find a translation for UCSD in other languages:
Select another language:
Discuss this UCSD abbreviation with the community:
Use the citation below to add this abbreviation to your bibliography:
"UCSD." Abbreviations.com. STANDS4 LLC, 2017. Web. 29 Mar. 2017. <http://www.abbreviations.com/term/1406371>.


text:
General English
- noun the player who bowls the ball at the striker's wicket
- noun a player who specialises in bowlingCitation 'To understand Sobers' greatness properly, however, one has to look at the fact that Bradman, Harvey, Hutton and all the others with whom one could make a comparison, save Hammond, were not bowlers' (Manley 1988)
- noun (in combination) a player who bowls balls of a particular type or who has a particular function in the bowling attack (as in 'spin-bowler', 'change-bowler', etc.)
- noun a chav. The term may refer to a supposedly characteristic bowl or swagger. The term was posted on the b3ta website in 2004.
- noun someone who plays bowls
Origin & History of "bowler"
The bowler hat was apparently named after the Bowlers, a family of 19th-century London hatters who specialized in its manufacture. The first known reference to it comes in the Saturday Review 21 September 1861: 'We are informed that he … wore … a white bowler hat'.


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There's no denying the rapid influx of technology in our world–screens and devices have invaded every corner of our lives whether we like it or not. The preschool classroom included. According to a 2015 survey done by Northwestern University, more than half of all preschool teachers use tablet computers in the classroom, a number that doubled from a survey done just two years prior.
But with so many choices out there, which are the best, affordable devices for use in a preschool or childcare setting? We've done some research and internal testing here at brightwheel, and have a few recommendations for both tablets and mobile devices.
Aside from price, the most important feature criteria to consider include:
- Screen size vs. mobility (i.e. tablet vs. mobile phone)
- Operating system (for effective navigation and optimal functionality of all the latest apps)
- Check out our app in the Apple app store or Google Play store to see the oldest OS versions we support
- Memory space
- Camera quality (we recommend a minimum of 2MP – ideally 3+ MP)
*NOTE: Brightwheel's app works for most all Android devices (via the Google Play store) and Apple mobile devices.
Tablets are a great choice, especially when used as a check-in kiosk. A few tablets we recommend:
This is a solid choice from Asus. 5 MP camera; Can find for less than $150, and some sales for less than $100.
This tablet has average handle and UI. 3 MP camera; Can find for less than $150.
Mobile Devices:
Although a lot of schools do lean towards tablets, we often recommend mobile devices for in-class use because you can easily use brightwheel and quickly put it away. In this case, you wouldn't actually need to use the phone functionality; you can just put in on wi-fi.
A popular choice in the classroom for Apple fans, the 8 MP camera is amazing. Options ranging from 16 to 128 GB, with the latest models priced between $199 and $399.
For more affordable options, this is our top Android phone recommendation, balancing quality and cost:
This one handles quite well with solid UI. 5 MP camera, Can find for less than $100.
This would also be a good time to mention that here at brightwheel we have worked tirelessly to build a platform that makes teachers lives easier, streamlining their processes, allowing them more time to engage with kids.
Brightwheel is a free, easy-to-use app for preschools, daycares, and families. Download it today and get started!


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Slide your iPhone 4G in this shell. This will protect the Shell casing of your iPhone 4G, protection of the screen with a front cover, you will also have access to al touchscreen while protecting the screen.
Material: Rigid Plastic
Compatible with:
IPhone 4 *
* 1 x Shell iPhone 4G Red Front and Rear


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Email email@example.com
1958 Crestliner Commander (speedster) 12' ???
This is the drain plug.
Bottom Scaling
The bottom has seen some corrosion probably from sitting on dirt or grass.
Sheet Metal Fasteners?
I think there have been a couple attempts at restoring this boat. The front deck is fastened by a combination of pressed rivets and pop rivets. The center deck, seats, transom etc have a mixture of everything and anything they could find and most of it is rusted.
Steering Hardware.
The boat still had a few cable guides mounted along the insides and return springs mounted under the transom corners. If they were used it may have been for front seat steering.
I found a number "A 155 H" stamped in the transom and on the starboard side at rear edge of the front deck. It also looks to have had the older Crestliner logo with the waves underneath it.


text: Well firstly I should say we were there as part of a food walking tour so only sampled a portion of food. It was the kale, which was not to my liking as it had a dairy free sauce on top. There were also other samplers which were all Vegan and Organic. The interesting part to this was the the... More


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Decontamination at a suspected radiological incident
Level B Suit Boots Inner Gloves Outer Gloves Helmet SCBA Chem-Tape (Duct Tape)
Donning and Doffing Level B
Remove watches, jewelry, etc. Remove items that impede movement Remove items that may puncture the suit Remove items that you dont want decontaminated
Remember to work as a team Remove Shoes Put Suit on to Waist Put on the Oversize Boots Tape the Boot to the Suit using Chem Tape Continuous piece of tape At least one circumference around boot Complete seal; no gaps between boot and suit Remember toCreate a Pull Tab Donning Level B:
Don Inner Gloves Don Outer Gloves Tape the Outer Glove to the Suit using Chem Tape Bend at elbow before taping to create greatest mobility Use one continuous piece of tape Wrap at least once around the forearm Seal the gaps Create a Pull Tab Zip suit to just below the neck in preparation for donning of SCBA Don SCBA Pack Don SCBA Mask Don, Zip and Seal the Level B Suit Hood Tape Facepiece and Hood Check visibility Place three pieces of tape Overlap the ends of the tape Seal the hood to the facepiece Create Pull Tab for each piece of tape On Air Ready to Work
Doffing Level B: Complete final decon rinse station Step into large size plastic trash can liner removes SCBA harness from back protecting the facepiece, regulator and hoseline Sit down Use Pull Tab to remove tape from Boots Place tape in trash can liner Doff Boot Remove Tape from Facepiece Unzip suit Remove Hood; Start to Peel… Remember to keep hand on outside of Suit! Pull Hand from Sleeve Peel down suit like a banana Step Out of Suit
Continuous Air Flow! With the gloved hand loosen the facepiece straps and gently push the facepiece away from the face with activated Bypass (open or on) Air MUST continue to flow away from the routes of entry to the body Remove inner Glove Report to Medical Surveillance
Nuclear Boy!
Recommended Personnel Contamination Survey
Contamination Survey Hands (Pause at Palms for approximatly Five Seconds Arms Have the Pt Turn their hand and Arm Over Backside of Hands and Arms (Pause at each elbow) Top and Sides of Head, Face (pause at mouth and nose for approx 5 seconds) Chest and front of Abdomen Front of the Legs (pause at each knee) Shoe Tops Shoe Bottoms (Pause at sole and heel) Have the person being surveyed Turn Around.
Contamination Survey Back of the head and Neck The Back and Pelvis (pausing at the seat of the pants) Back of the Legs Any dosimeters worn by the person being surveyed. If the dosimeter is not contaminated return to person.
Roles and Responsibilities Decon Group Supervisor
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Light and comfortable tank top with graphic pocket detailing referencing to The Boracay Sunset leggings design.
Incredibly soft fabric and relaxed loose fit makes this tank top a perfect addition to your everyday workout plan. Wear it at the gym, at a yoga session or during an intense cardio practice.
We are all about strong and empowered women who go out and grab the world by the tail. Find your inner spirit animal with Noly!
- Strength – four and six channel fibre is thrice as durable as others
- Easy care – our fabric dries 8 times faster than cotton
- Softness – it's smooth and incredibly comfortable
- Breathability – capillary transport system helps to keep thermal control by pulling moisture away from the skin
- Lightness – our fabric is 20% lighter than most of similar type


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B&Q Metal Deck Screw (Dia)4mm (L)65mm, Pack of 250
B&Q Metal Deck Screw (Dia)4mm (L)65mm, Pack of 250
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This pack of Pozidrive number 2 drive recess bugle head decking screws are constructed from a durable metal, 65mm in length and come partially threaded on longer screws. They can be used on 65mm chipboard.
- Corrosion resistant
- Guarantee - 1 year
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- Accessories included: Philips #2 driver bit
Technical Specifications
Brand | B&Q |
Model | 27713044 |
Length | 65mm |
Diameter | 4mm |
Screw/Bolt head type | Bugle head |
Material | Metal |
Drive recess | Pozidrive number 2 drive recess |
Pack quantity | 250 |
Pack weight | 1.045kg |
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text: The Koepelcafe serves a really great burger made to order will a variety of topping offers. This is not your run-of-the-mill hamburger, but truly one to be enjoyed with piping hot fries and an ice cold beer. This café has extremely friendly and polite bar staff. Seating is somewhat limited; dining at the bar is available and was my choice... More


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I'm Not Built For The City
Roderick Campbell
by Janne Robinson
I'm not built for the city.
I'm ungrounded by the red cars, yellow taxi cabs whizzing by, the people honking, their car windows unrolled and music blasting.
Read MoreUse the form on the right to contact us.
You can edit the text in this area, and change where the contact form on the right submits to, by entering edit mode using the modes on the bottom right.
123 Street Avenue, City Town, 99999
(123) 555-6789
You can set your address, phone number, email and site description in the settings tab.
Link to read me page with more information.
by Janne Robinson
I'm not built for the city.
I'm ungrounded by the red cars, yellow taxi cabs whizzing by, the people honking, their car windows unrolled and music blasting.
Read Moreby Janne Robinson
I practice attachment.
I practice living with my heart wide open and feeling the surplus of joy and sadness that it comes with each day, rawly.
I fall in love with someone's heart at least once a day.
Read Moreby Janne Robinson
ello concertos
sometimes the men
who amuse my heart
beating strongly
in the April heat
with sweat
black flies
are not for me to love
by Janne Robinson
I am afraid of being left.
I'm not afraid of love, I'm afraid of loving so hard that I can be left, again.
I remember the moment I sat in green and wheatgrass fields at dusk in my father's village in Tertsa, Greece, drinking water from the mountains. He broke the air filled with the singing of crickets to tell me that he had received the postcard my mom sent with a letter that I had been born.
Read Moreby Janne Robinson
I don't want to love you tonight
I don't
I want to go sit in my rocking chair
I want to put on Gregory Alan Isakov
light a blue candle that doesn't smell like a thing
I wish to take off the day
and sit naked
by Janne Robinson
Stop buying plastic crap.
We don't need more Dora the explorer sippy juice cups—we just don't. If we stop buying so much junk, they will stop making so much junk.
Shave your legs with the water off. Turn the water off while you condition your hair.
Read Moreby Janne Robinson
A haze of tired faces
10 hours spent in traffic jams
Jesus, give us a break
the 'stache of a 70s pornstar
shirt unbuttoned
gold rimmed glasses
bronzed chest
a triangle on his left arm
by Janne Robinson
Date a woman who takes espresso at dusk, passion fruit cheesecake before dinner and red wine with her fish.
Date a woman who would rather hitch hike, throw her thumb out and fall into the trust of strangers—fly through green hills with white cows and pink flowers as the sun beats and the dust bellows on the back of a motorcycle in a white sun hat.
Read Moreby Janne Robinson
We attract lovers and partners who are putting out what we are putting out into the world.
We essentially are dating ourselves.
We are big-ass mirrors—walking around dancing with others and ourselves at the same time.
Read Moreby Janne Robinson
Social media doesn't paint a whole picture, and I want to be frank on why I'm living in paradise.
I'm not making enough money off my writing, my job, (not a hobby) to live off it and survive in Canada.
Read Moreby Janne Robinson
Recently someone, who I don't know well, reached out to me and bared her heart.
I didn't respond right away.
It was long and deserving of presence and time, both which I didn't have when I received her message.
Read Moreby Janne Robinson
I am worthy of a love where a man only rushes from my side in the first white sheet crinkles of the morning to make me espresso.
I am worthy of foot massages with oils made from herbs grown in the wild, without the aid of chemicals—from the earth's belly.
Read Moreby Janne Robinson
I am sad this morning
the yellow sunflowers are sad
my cold toes upon the hardwood floor are sad
the roses refuse to smell sweetly this morning
and my blue heart aches
for I am unable to open
I am unable to crack my heart in my chest for you
by Janne Robinson
Sometimes love stories are not love stories, and sometimes they are if only for a minute.
Sometimes there is romance and grandiose gestures and we wish to fall in a New York minute heart beat, but we simply don't.
by Janne Robinson
I wish to rest into you
my love
possibly collapse
and I know we mustn't
Read Moreby Janne Robinson
I was interviewed this morning by Meena Avery of Impress me, Please?
On her podcast show we were talking about the word perfect.
I have a theory: we should all take the word "perfect," throw it out the window and run over it a few times.
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At my funeral there will be sunflowers, yellow and heavy with joy.
I wish guests to wear white, and come barefoot.
I want Bluebird by Charles Bukowski read and good scotch—not necessarily expensive scotch, but scotch some may keep on a shelf, collecting dust, waiting for the perfect moment to breathe—if you're into that sort of thing.
Read Moreby Janne Robinson
Don't go in there
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The toilet seat's never been cleaned?
I'll have to hover and squat and not touch the wall,
for shit's been smeared upon them?
Read Moreby Janne Robinson
It all leaks out
over tea light candles
in an orange hammock
red triangle pillows
so deliriously tired
the thoughts exit my mouth
by Janne Robinson
I'm on the way to kiss a man goodbye
he asks to come with me
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I smile
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except the kind of flies you don't mind


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Faglegt efni
Heather Stockton
Human Capital Leader, Canada
Heather is Global Human Capital leader for the financial services. She is a member of the Board in Canada and Chair of the Talent & Succession Committee. Through her work in developing and executing strategic plans, Heather has become an advisor to executives who are undertaking business transformations, merger integrations, or changing their operating model. She has extensive experience in talent strategy and leadership development for leaders and boards.
Tengt efni
Faglegt efni
Leaders at all levels
Leadership remains the top human capital concern — and the largest "readiness gap" in our survey. The need: develop new leaders faster, globalize leadership programs, and build deeper bench strength.
Faglegt efni
Beyond Yahoo
Marissa Mayer's decision to revoke Yahoo's telecommuting policy stirred the debate about flexible workplace strategies. Is the move to virtual work inevitable?


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Region: | Mid-Atlantic |
Setting: | Small Town Setting |
Type: | Private/For Profit |
Affiliation: | Not applicable |
Size: | Small (Under 2,000 Students) |
Website: | www.ncstrades.edu |
On-Campus Housing Available: | No |
Selectivity: | Selective |
Tuition: | $16,750 |
Retention Rate: | 70% |
Enrollment: | 1,291 |
Year Established: | 1946 |
About New Castle School of Trades
With full degrees taking over the American educational philosophy, the effectiveness of technical and trade schools have been largely ignored. Technical and trade school is alive and well in western Pennsylvania at the New Castle School of Trades (NATTS).
For students who don't feel that a liberal arts education will suit or interest them, highly valued careers in automotive technology, building technology, welding, heavy equipment operators and refrigeration technology are just some of the areas of specialized education offered by the New Castle School of Trades.
Hands-on training best prepares students for their daily lives in these highly technical fields, and evening classes are also offered for workers or other busy adults who want to enhance their skills.
Financial aid is available to those who qualify through federal grants and loan programs and the School of Trades has a competent staff to help guide you through the forms and paperwork.
The career services division of New Castle School of Trades has a three-pronged program to help transition the student to work through:
• Professional Development Advising
• Visits by local prospective employers
• Contacting local employers
Programs can last from six weeks to 60 weeks depending on the program, and part-time attendance can be accommodated.
The New Castle School of Trades is accredited by the Accrediting Commission of the National Association of Trade and Technical Schools.
New Castle School of Trades Map & Location
New Castle School of Trades
4177 Pulaksi Road
New Castle, PA 16101
Getting Around New Castle School of Trades
Poor walkability. We recommend using a car for this area.
Seasonal average temperatures for New Castle, PA
Total Students | 1,291 |
Ethnic Diversity:
- Latino: 2%
- African American: 13%
- Caucasian: 84%
- American Indian or Alaska native: 1%
Latino | 2% |
African American | 13% |
Caucasian | 84% |
American Indian or Alaska native | 1% |
Other Schools Near New Castle, PA
- Pittsburgh Colleges (35)
Where does this school information come from?
This web site and associated pages are not associated with, endorsed by, or sponsored by New Castle School of Trades. CampusExplorer.com has no official or unofficial affiliation with New Castle School of Trades.


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v.3.12 rev.1
main page
Japanese name: | パクノダ |
Gender: Female
Occupation: Phantom Troupe
Nen type: Specialization
Abilities: Reminiscence Scan; Conjured Pistol Memory Bomb: (Recollection Bullet)
Pakunoda was one of the members of the Phantom Troupe, an infamous gang of thieves with class A bounties. Her physical strength ranks eleventh in the group and former #9 Troupe member.
Pakunoda exudes an air of self-confidence that can be intimidating to others. Pakunoda is completely loyal to Chrollo, and even goes against the Troupe and Chrollo's own saying that the survival of the group comes before the well-being of the leader in order to rescue him. Pakunoda is very loyal to the Spider as well, as she sacrificed herself so that her comrades could know about Kurapika's ability.
Pakunoda is one of the original members of the Phantom Troupe along with Franklin, Machi, Feitan, Chrollo Lucilfer, Nobunaga Hazama, and Uvogin that originated from Meteor City. It is a junkyard city inhabited by outcasts that refuse to be part of society. People who live there do not exist in any official records, and the existence of the city itself is known to very few people. It is also stated in the manga and anime that original members of the Phantom Troupe had something to do with the bad blood between the Mafia and the people of Meteor City. Why the Troupe left the city is a mystery. Later, the group was joined by more members, in accordance with Chrollo's idea of a group comprising of exactly thirteen members, including himself.
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Hunter x Hunter (2011) | Season 2 | TV | 148 | 8.95 | 9.02 | ||
Gekijouban Hunter x Hunter: Phantom Rouge | Movie 1 | Movie | 1 | 8.06 | 8.18 |
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Legae Alumni Network
An exciting aspect of the website redesign we did for Legae was the creation of a customized Social Network for past and present employees of Legae. Inspired by Goldman Sachs who offers a similar service to employees, Legae CEO Lawrence Madzwara specifically requested the feature for the website. This is what Goldman Sachs CEO Lloyd C. Blankfein has to say about their Alumni Network site:
"Even after our people leave Goldman Sachs, they still identify with the firm and we want to foster that connection. We have a rich history and tradition, and we invest in it. Our alumni help us recruit. They participate in volunteer activities. They come back to speak to our people, and they do business with us. Not only does this help validate our culture, it provides a real, tangible value that transcends any single generation."
The social network will allow Legae Alumni to remain in contact long after they have moved from Legae, as well as enabling Legae to use the platform to improve the work environment for current employees, based on open, honest feedback from former employees. The Social Network is built on the excellent Ning platform, which allows for the rapid creation of a Facebook style community that is open only to Legae Alumni, ensuring privacy and exclusivity.
The home page of the Legae Alumni Network. The Facebook style layout lets people feel at ease right away.
A typical Profile page
The online chat feature allows Legae Alumni to reconnect and catch up with colleagues.
- Log in to post comments
Like what you see?
We'd love to work with you on your next design project.


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Sci fi/Fantasy image by
Chantal Jean BouchardI caught this faerie while I was dusting up my bookshelves. It appears she was allergic to the feathers of my duster. I apologized but she only laughed and pulled my hair before running/flying away.This work was done for the Faerie Exchange of June on live journal. This character is not mine.
Published More than a year ago
Category Anime/Manga
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We believe horse riding is one of the most exhilarating experiences! However, the joys of life are boundless and, so, we have packed our holidays with many of the unseen joys on this island. Dine out every evening and see so much of what is Sicily.
Explore the natural and historical beauties of one of Italy's most precious regions. This unique one week journey, in the heart of Italy, includes a daily meditation and yoga practice, as well as visits to breathtaking landscapes and historical spots
Charming B&B in the hearth of Palermo historical centre, Ai Cartari is quite, elegant and comfortable.
The largest selection of holiday homes, apartments, villas in Trapani, San Vito Lo Capo bay cornino, Erice, trapani, bonagia. Car rental services, bikes, scooters, boats. Transfer. Desk.
The classic Ridocco farm, built in the mid 19th Century and occupied by the same family, stands in the majestic mountains of central Sicily a few kilometres from Corleone.
Il Gelsomino is a welcoming B&B in Paceco, a few km from airport of Trapani, Erice and the beautiful sea of S.Vito Lo Capo. The staff will offer a nice breakfast on terrace with local products, and you will spend a special holidays in Trapani.
B&B Belveliero in an ancient building with balcony with sea view, exalted by its typical arch in Trapani old town, in front of bus stop to airports, in front of harbour where hydrofoils connect everyday to Egadi islands, and 400 metres to sand beach.
Cinisi, Italy visitors guide to accommodations, adventure travel, unique tours and rentals. Check out top Cinisi, Italy getaways & destinations. Cinisi, Italy vacations, packages & travel spots. Visit Cinisi, Italy !.


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No difficulties - this is a hike.
Windy Point Ridge is that section of highway in Sheep River P.P. that always has sheep near it. It also parallels Foran Grade and there's several hikes in the area.
After snowshoeing Foran Grade, I set my sights on the slightly higher Windy Point Ridge. I followed a good trail down from the summit of Foran Grade but near the pass I had to forge my own path straight up to the summit ridge of Windy Point - and it was bloody steep. The bitter cold actually helped me at this point - the slabby snow held my weight about 60% of the time. The other 40% was spent cursing the sugary stuff underneath the slab... ;-)
The summit views were quite limited, but just back from the summit the views were pretty good - much better than I was expecting given the weather forecast. I decided to take the shortest path to the highway and trudge back to my truck along it. This worked well and within 3.5 hours of leaving the truck I was back. Probably among the easiest two summits I've ever done - but the solitude and views were just what I needed on this bitterly cold February day.
[Starting down Foran Grade - the north end of Windy Point Ridge visible.]
[Nearing the pass - Windy Point Ridge rising above. ++]
[The entire Windy Point Ridge (summit on left) from near the pass. ++]
[I went straight up through the light forest.]
[Some animal was doing this to the bark all over the place - deer or moose?]
[The slope was pretty steep near the top.]
[Limited summit views. ++]
[A much better view from the top of the escarpment over the highway - just back from the summit. ++]
[Foran Grade and the highway. ++]
[Interesting formations from the descent, looking back up Windy Point. ++]
[A final glance back at Windy Point Ridge from the highway on return.]
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Sci fi/Fantasy image by
T. Nytehymn' SommersThis is Crimson the day of his wedding day. No he was a noble and a darvinesti elf they dont smile and they dont show any form of emotion in public. In fact husband and wife are only allowed to touch each other in public is in their wedding they can hold hands. The darvinesti elves marry for life.
Published More than a year ago
Category Fantasy
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Product Actions
- Waterproof full-grain leather upper
- Pig Leather Lining
- Aegis Antimicrobial Tech
- Numentum®Insole
- eVent waterproof Tech
- Custom Vibram outsole utilizing XS Trek compound for traction on a variety of surfaces
- Numentum®Hike technology that is engineered to center and guide the foot to promote balance when traversing trails. Soft-density EVA in the heel surrounded by higher-density foam around it provides all-around stability on the trail. This enables cushioned feel of an athletic shoe, but with the heel stability of the most rugged hikers.
- Weight 1/2 Pair, Size 7: 13.5 oz.
Product Reviews
by PowerReviewsPros
- Comfortable (4)
- Good cushioning (3)
- Great traction (3)
- Lightweight (3)
- Stable (3)
Best Uses
- Sizing:
Feels too small
Feels true to size
(3 reviews)
Feels too large
- Reviewer Profile:
- Casual/ recreational (3)
- Was this a gift?:
- No (4)
Reviewed by 5 customers
Displaying reviews 1-3
Previous | Next »
- Ankle Support
- Comfortable
- Durable
- Good Cushioning
- Great Traction
- Lightweight
- Pronation Control
- Stabilizes Foot
Best Uses
- All Weather Conditions
- Everyday
- Grass
- Mixed Terrain
- Muddy Conditions
- Paved Trails
- Rocky/Unstable Terrain
I use these shoes for summer hikes and threaded through Michigan winters, and they somehow aren't too hot in summer and are warm enough in winter with wool socks underneath. They're very comfortable and durable and they look so nice that I can wear them as an everyday shoe in winters. The ankle is supportive yet just flexible enough and they're easy to get in and off. They also break in nicely. Very pleased with this purchase!
- Sizing:
- Feels true to size
- Width:
- Feels true to width
- Was this a gift?:
- No
Decided my midnight blue pair were too cute and comfortable to trash on the muddy trails so I added a black leather pair. After wearing both for a few years I added the low version as a hot weather hiker and casual walking shoe. Back looking at a new pair for hiking so I can downgrade the original to yard and garden use. My feet don't want to be in anything else!
- Ankle Support
- Comfortable
- Durable
- Good Arch Support
- Good Cushioning
- Great Traction
- Lightweight
- Pronation Control
- Stabilizes Foot
Best Uses
- All Weather Conditions
- Everyday
- Grass
- Mixed Terrain
- Muddy Conditions
- Paved Trails
- Rocky/Unstable Terrain
Comments about Ahnu Montara Boot WP:
These are great boots and a love the way they look. I have nueromas in one of my feet so have to move to a different boot because Ahnu doesn't offer wides. My feet aren't wide, I just need a little more room in the toe of my left foot.
Please consider offering wides - especially in hikers.
- Was this a gift?:
- No
Displaying reviews 1-3
Previous | Next »
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Get answers from our staff experts by clicking "Ask a Question" or click here to send an email to our customer service team.


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The high cost of constructing affordable housingBy Molly WoodAugust 19, 2016Dan Kitwood/Getty ImagesDevelopers don't make money on them, so they aren't getting built.POSTED IN: affordable housing Housing cities poverty ListenreadDownloadDownload
Facing job discrimination without legal protectionBy Lewis WallaceJuly 29, 2016Drew Angerer/Getty ImagesLGBTQ people, especially trans people of color, are more likely to be poor.POSTED IN: Orlando poverty employment discrimination ListenreadDownloadDownload
When you can't make bailBy Sabri Ben-AchourJuly 27, 2016Spencer Platt/Getty ImagesFor some people, posting even small bonds can be a huge burden. POSTED IN: bail bail funds poverty ListenreadDownloadDownload
The Edelmans: 50 years of fighting for equalityBy Kai Ryssdal and Tommy AndresJuly 21, 2016Courtesy of James Lucas EstateThe couple who met on Kennedy's Delta tour and have carried on his torch for change. POSTED IN: poverty racism South ListenreadDownloadDownload
The other Cleveland: Crossing the divideBy Kai Ryssdal and Tommy AndresJuly 18, 2016Tommy Andres/MarketplaceThe Mississippi Delta has the lowest economic mobility of anywhere in the developed world.POSTED IN: poverty race class mobility ListenreadDownloadDownload
Far from convention lights, life in Cleveland, MississippiBy Kai Ryssdal and Tommy AndresJuly 15, 2016Tommy Andres/MarketplaceA divided city in a divided state in a still-divided country. POSTED IN: poverty Robert Kennedy Mississippi ListenreadDownloadDownload
Getting enough food is still a problem for many AmericansBy Annie BaxterApril 28, 2016Stephen Chernin/Getty ImagesA new report points to a persistent problem of food insecurity.POSTED IN: food insecurity poverty hunger ListenreadDownloadDownload
How long you live depends on where you live, if you're poorBy Jed KimApril 11, 2016Mario Tama/Getty ImagesThe rich tend to live 10+ years longer than the worst-off. Health choices matter.POSTED IN: life expectancy Wealth and Poverty geography ListenreadDownloadDownload
Helping babies deal with toxic stressBy Eilis O'NeillMarch 29, 2016Eilis O'Neill/MarketplaceA new approach supports parents, lessening toxic stress on a baby's brain.POSTED IN: babies Health poverty stress ListenreadDownloadDownload


text:
As expected, France was heavily dependent on power imports during the first cold spell of this winter. Yet, most of the country's reactors are back online. The US is now also investigating 17 reactors with parts from France that could also be defective. Craig Morris has the details.
All posts tagged: France
French solar roads – silly walks
France's environmental minister Ségolène Royale is rolling out 1,000 kilometers of a technology that will both be bad solar and bad road. Craig Morris critiques.
The long history of "recently discovered" nuclear safety issues
This week, German media reported a different angle on the "micro-fissures" now plaguing nuclear reactors in Europe. It seems that the risks have been known for decades. Craig Morris takes a look.
Thorium: a future option for nuclear?
Nuclear reactors running on thorium are widely held to be inherently safer than the awful pressurized-water reactors we have today. So why don't we have thorium reactors? A new TV documentary also available online answers the question quite well. Craig Morris sums up the evidence.
Swiss try to give away nuclear plants, find no taker
The operator of Switzerland's nuclear reactors, Alpiq, reportedly offered reactors to France's EDF at no cost or "a symbolic franc." The French, who have their hands full with their own struggling fleet at home, refused the offer. A potential power shortfall still looms in the background. Craig Morris explains.
EDF's epic tale: lost in transitions ?
It is finally done. After months of dithering, the nuclear industry's CEOs and government officials of the UK, France and China solemnly signed off on the nuclear plant project at Hinkley Point C at the end of September. Some maintain that these might be the first signs of a new era for nuclear power after the Fukushima catastrophe, but Hinkley can barely hide the fact that the French nuclear "champion" EDF is at the brink of collapse and urgently needs a strategic turnaround. Andreas Rüdinger explains.
Guess which big EU country might have blackouts this winter?
At present, 21 of France's 58 nuclear reactors are offline. The country's power prices have skyrocketed, as have imports. Power from fossil fuel is increasing, and the country has now postponed its plans to implement a floor price on carbon. Craig Morris explains why.
The best nuclear year followed by an immediate slump
This year's World Nuclear Status Report was published in July. 2015 turns out to have been the best year for new nuclear builds in a quarter of a century, but nothing at all has been completed yet in 2016. Craig Morris takes a look.
Nuclear weapons and nuclear power in the UK
What would Brexit mean for the proposed nuclear reactor at Hinkley and England? No one really knew—until the new government in Downing Street announced the refurbishment of its nuclear submarines. Shortly thereafter, London confirmed that it remains committed to Hinkley—before postponing a final decision once again. Craig Morris explains.
French nuclear under pressure – from German renewables?
In late May, strikes reduced nuclear power production in France. Yet even more plants were offline a few weeks earlier without any strikes at all. German and European renewable electricity may have been one reason why France switched off so many nuclear plants that weekend. Craig Morris takes a look.


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Seeking a way through the world we live in...
Thursday, February 16, 2012
Getting to know us...(the point of all these pics)
Hi everyone...el dorko supremo!
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28 replies | Author | Time | Post |
sinkingfeeling | Aug 2013 | OP |
Harmony Blue | Aug 2013 | #1 | |
seabeyond | Aug 2013 | #3 | |
yurbud | Aug 2013 | #23 | |
seabeyond | Aug 2013 | #2 | |
Squinch | Aug 2013 | #4 | |
seabeyond | Aug 2013 | #5 | |
MisterP | Aug 2013 | #6 | |
Adam051188 | Aug 2013 | #8 | |
MisterP | Aug 2013 | #13 | |
seabeyond | Aug 2013 | #17 | |
mythology | Aug 2013 | #25 | |
Demo_Chris | Aug 2013 | #7 | |
Adam051188 | Aug 2013 | #9 | |
Demo_Chris | Aug 2013 | #12 | |
Adam051188 | Aug 2013 | #11 | |
tclambert | Aug 2013 | #19 | |
Demo_Chris | Aug 2013 | #24 | |
ornotna | Aug 2013 | #10 | |
Adam051188 | Aug 2013 | #14 | |
SunSeeker | Aug 2013 | #22 | |
bravenak | Aug 2013 | #26 | |
Post removed | Aug 2013 | #15 | |
Lunacee_2013 | Aug 2013 | #16 | |
LanternWaste | Aug 2013 | #18 | |
Sheldon Cooper | Aug 2013 | #20 | |
seabeyond | Aug 2013 | #21 | |
jimlup | Aug 2013 | #27 | |
felix_numinous | Aug 2013 | #28 |
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 02:23 PM
Harmony Blue (3,978 posts)
1. Sad thing is in many colleges that start this week, next week or a in a couple weeks...
the focus is not on defining rape for young college students to comprehend...
Response to Harmony Blue (Reply #1)
Mon Aug 19, 2013, 02:28 PM
seabeyond (110,159 posts)
3. i really want to send a thread from du on college campus covers up rape thread to
the woman athletic director coach in the university i just sent my son to. and tell her this is the ONLY thing that i think schools fail at. being woman, and the athletes respecting her so, i would like for her to have a meeting expressing how cover up of rape will NOT be tolerated and the victim will not be victimized a second time. the rapist will have repercussions to a criminal behavior.
Response to Harmony Blue (Reply #1)
Mon Aug 19, 2013, 05:11 PM
yurbud (37,823 posts)
23. frats exist to do about half of those listed
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 02:26 PM
seabeyond (110,159 posts)
2. duh, right? hmmm, seems needed. put THIS in the airforce MENS bathroom
and the athletic locker room and the university campus bathroom wall.
the thought to this is a thread that expressed the airforce put up a poster in the womens bathroom... how to avoid getting rape. |
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 02:41 PM
Squinch (16,604 posts)
4. Personally, I don't believe there are many men out there who don't know this.
I don't really believe there is much confusion. I think there are just a lot of guys claiming ignorance so they can do whatever the hell they want without having to think of the person in front of them as a person.
Response to Squinch (Reply #4)
Mon Aug 19, 2013, 02:47 PM
seabeyond (110,159 posts)
5. true taht but what i do think it does for all the boys.... and men that observe or hear about the
behavior is giving them a very clear message to speak up.
like all the kids that watched stuber...rape, and said nothing. this clearly says.... do not keep mouth shut, tis a crime. with rape as entertainment today, in all forms from comedic jokes to hot series and every man movie, our kids are getting lackadaisical on the act. |
Response to Squinch (Reply #4)
Mon Aug 19, 2013, 02:47 PM
MisterP (23,730 posts)
6. +1--clarifying what rape is won't stop rapists: it's not an accident
Response to MisterP (Reply #6)
Adam051188 This message was self-deleted by its author.
Response to Adam051188 (Reply #8)
Mon Aug 19, 2013, 03:50 PM
MisterP (23,730 posts)
13. it may be useful to put "no gutshots" signs in inner LA and Detroit, but one can't stop there
Response to Adam051188 (Reply #8)
Mon Aug 19, 2013, 04:37 PM
seabeyond (110,159 posts)
17. mmmm, and how many times have you chuckled watching a movie about getting a girl drunk to get some
or some guy joking about getting date drunk or the many variants?
oh, right, in this culture you have NEVER heard this, just the few psychos talk like that and only to themselves. it is so comforting to tell ourselves that it is just the few, when we see stuberville and groups of kids ignoring an unconscious girl being dragged from party to party assaulted or worse filming it and sending it out on social network, then later blaming, terrorizing and threatening her. you know, part of the problem. a town protecting rapists. validating that "good boys" do not rape. why ruin their future. just a sl*t, after all. really, much easier pretending there is not an issue and turning away. hence... you prove the very point for the need of education for our boys and men. |
Response to MisterP (Reply #6)
Mon Aug 19, 2013, 05:49 PM
mythology (6,523 posts)
25. Vancouver Canada found that reported rapes dropped 10%
after a public service campaign to explain what rape is:
http://www.huffingtonpost.ca/2012/12/01/edmonton-sexual-assault-awareness-campaign-dont-be-that-guy_n_2224228.html While obviously it's not eliminating rape, it's at least a step in the right direction. |
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 03:20 PM
Demo_Chris (6,234 posts)
7. Wait, what? When in the hell did THIS happen?!!!
Kidding of course, but I am making a point as well.
The rape problem is not caused by ignorance. Adult men and teens who have sex with comatose partners already knew this was illegal. And if they don't understand this by now a chart like this one isn't gonna help them. Some men (and women) are rapists. They know they are rapists. I don't know why they are the way they are, but you are not going to educate them out of it, and trying to shame and blame all men as if they were also rapists or imbeciles is not really a solution. I am not really sure what the solution is. Those offering advice to potential targets (to help them avoid becoming victims) have inevitably been flamed and accused of blaming the victim. Along the same lines, efforts to teach boys some code of chivalry -- that they have an obligation as men to defend women and treat them with courtesy and respect -- are often met with scorn from the feminist community. Which leads us to where we are today: Infographics. |
Response to Demo_Chris (Reply #7)
Adam051188 This message was self-deleted by its author.
Response to Adam051188 (Reply #9)
Mon Aug 19, 2013, 03:46 PM
Demo_Chris (6,234 posts)
12. That's what I do. In any case this is a side issue that might derail the topic of this thread...
So I will leave it there.
Response to Demo_Chris (Reply #7)
Adam051188 This message was self-deleted by its author.
Response to Demo_Chris (Reply #7)
Mon Aug 19, 2013, 04:55 PM
tclambert (8,832 posts)
19. Ted Bundy said it was about feeling powerful.
He started out as a rapist. He killed to eliminate the witness. Then he discovered the killing made him feel even more powerful. And that's how rapists evolve into serial killers.
People seem a lot clearer on the subject of murder. They never ask, "What was she wearing? Did she ASK for it?" Maybe if they looked at rape as being on the developmental path to murder, . . . Nah, some people just aren't gonna get it. |
Response to tclambert (Reply #19)
Mon Aug 19, 2013, 05:34 PM
Demo_Chris (6,234 posts)
24. Perhaps. The problem with Bundy is that he LOVED to spew BS...
Many sociopaths are masterful liars and manipulators, but Bundy took it to an almost preternatural level. he coupled charm, intelligence, and pure evil in a way that has perhaps never been seen since. When it comes to Bundy, the only thing you can reliably say is that nothing he said should be considered credible at all. And yet, remarkably, people believed him -- to some extent because he was gifted at mimicking sincerity and telling people the "truths" that they wanted to hear.
To give you an idea just how extraordinary his ability to bullshit and manipulate was, consider the following quote. This was what the JUDGE in hiw murder trial said to him as he sentenced him to death: "It is ordered that you be put to death by a current of electricity, that current be passed through your body until you are dead. Take care of yourself, young man. I say that to you sincerely; take care of yourself, please. It is an utter tragedy for this court to see such a total waste of humanity as I've experienced in this courtroom. You're a bright young man. You'd have made a good lawyer, and I would have loved to have you practice in front of me, but you went another way, partner. Take care of yourself. I don't feel any animosity toward you. I want you to know that. Once again, take care of yourself." Note as well how thoroughly Bundy managed to bullshit James Dobson just hours before his death. This was the infamous "Porn did it" interview. Ted Bundy killed people because he was evil. He enjoyed it. It's not a leap to say that it made him feel powerful, but even this might be an error. I say this as someone who, in the past, has known and worked with a good number of serial killers and extremely violent sociopaths. It is a huge mistake to believe that you understand them or get where they are coming from, the ONLY correct way to deal with people like this is to treat them like you would a dangerous and hungry animal. The Tiger in the zoo might look relaxed, it might even let it's handler pet it and pretend to enjoy it, but if you make the mistake of forgetting it's a Tiger it will kill you. In any case, to respond directly to your point, many serial killers start out as serial killers, while relatively few rapists evolve into serial killers. Because of this, I think it's a mistake to draw too many conclusions from this. |
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 03:38 PM
ornotna (5,125 posts)
10. And another one
This has been posted before. And it's worth posting again.
Response to ornotna (Reply #10)
Adam051188 This message was self-deleted by its author.
Response to ornotna (Reply #10)
Mon Aug 19, 2013, 05:05 PM
SunSeeker (23,209 posts)
22. Love that one. #9 is my fave. nt
Response to ornotna (Reply #10)
Mon Aug 19, 2013, 06:11 PM
bravenak (34,648 posts)
26. Number six.
Have a non rapist help you not rape someone. Good idea, like a sponsor in NA.
Response to sinkingfeeling (Original post)
Post removed
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 04:26 PM
Lunacee_2013 (529 posts)
16. K & R, nt.
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 04:43 PM
LanternWaste (27,212 posts)
18. ome swimmers do indeed, need to be reminded of the rules now and again.
There was an idiot who noticed a safety-board at the local swimming pool listing do's and don't of safe swimming. He, being both an excellent swimmer and a petulant individual, took offense in a wonderful fit of pique, and began yelling that he didn't need to know these rules, that he was an excellent swimmer, and he wished people would stop haranguing him about the rules.
He never realized that some swimmers do indeed, need to be reminded of the rules now and again. |
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 04:59 PM
Sheldon Cooper (3,724 posts)
20. Here's another one:
Response to Sheldon Cooper (Reply #20)
Mon Aug 19, 2013, 05:02 PM
seabeyond (110,159 posts)
21. yup. but then, we have a culture, society, media that promotes rape continually. without calling
it rape and shwoing the horrific of it as a crime, but more just a sexual turn on cause really, we all know rape is wrong.
that is a very good post of yours. college boys. and they have done it with more than one college. number varies from 33% and higher. |
Response to sinkingfeeling (Original post)
Mon Aug 19, 2013, 07:12 PM
jimlup (5,530 posts)
27. I don't know if this post will become controversial but ...
I think it can happen both ways. Men can be raped I believe. It is certainly much rarer but I believe that it happened to me.
Response to sinkingfeeling (Original post)
Tue Aug 20, 2013, 01:41 PM
felix_numinous (5,198 posts)
is a sign if sociopathic creep in society (or more sociopathic creeps in society).
Or if you have to explain what is or what is not forced sex, or having to defend and explain other basic human rights like privacy, freedom of speech, press-- or what a real free society actually is. And if your explanation reaches deaf ears, and your repeated alternative and progressively dumbed down explanations don't help, this is a sign of a truly sick person, group or system. It is a litmus test actually. |


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Practice after breakfast puts golfer in the rough with wife
Dear Abby: Is it harmful for someone to practice golf swings right after breakfast? I'm talking about leaving the breakfast table and heading outside to the back yard and starting practice. The way I see it, swings exert a lot of effort. Swinging a club for 15 to 20 minutes could do damage to the internal organs, right? To say the least, I don't think it helps the digestion.
The "someone" I'm writing about is my husband. He plays golf almost weekly. The only time he doesn't play is when he is away on a business trip. I'm 100 percent behind him playing golf because it's good for his health. I just don't think that practicing any sport right after a meal is appropriate.
I brought this up with him, but he keeps saying that it's the only time he can practice. My argument is: Not being able to do it at some other time doesn't mean that one should do it at the wrong time.
Please enlighten me on this. If I'm convinced that it won't do my husband any harm, I'll shut up.
- Protective Wife in Santa Clara
Dear Protective: You appear to mean well, but you also appear to have some control issues. If your husband says he feels no ill effects from swinging after breakfast, please leave the poor man alone. Be happy you're married to someone who cares enough about his health to exercise. Many women are not so fortunate.
Dear Abby: I was recently on a cross-country flight. My seat partner was an East Indian gentleman. During the flight I noticed that he still had the label sewn on the left arm of his new suit. Because he didn't seem to want to talk, I respected his privacy and didn't tell him about the label.
Now I wonder if I, a red-headed Southern lady, should have told him about his label. Abby, what should I have done?
- Southern Belle
Dear Southern Belle: Because your seat partner was not inclined to talk, you should have done exactly what you did - which was keep quiet.
The label on his jacket may not have been there because of an oversight. Some designers put their labels on the outside rather than the inside, so wearers can publicize not only the brand they are wearing but the implied price they paid for the garment. (Long gone are the days of quiet opulence.)
Dear Abby: How do you respond to a woman who is nearly 50 but acts like a child in public at meals? My sister-in-law, "Heather," who is divorced, will hum very loudly and sing out at the table. The family just smiles and says something about how she must really like the song.
It's embarrassing! We've been in very expensive restaurants, and Heather is rocking and saying, "La, la, la" loudly, and people ask if she's impaired. What can I do? I cringe at any public event.
- Red-Faced in Vero Beach, Fla.
Dear Red-Faced: Heather may be making a bid for attention, which should strike you as more sad than embarrassing. Or she could have a mild form of Tourette's syndrome. Someone in the family - not you - should speak to her about it.
However, if she's unwilling or unable to "change her tune," you'll just have to accept her, eccentric as she is. It's really no reflection on you, and after all - she's family.
For an excellent guide to becoming a better conversationalist and a more attractive person, order "How to Be Popular." Send a business-size, self-addressed envelope, plus check or money order for $6 to: Dear Abby Popularity Booklet, P.O. Box 447, Mount Morris, IL 61054-0447.
Write to: www.DearAbby.com or P.O. Box 69440, Los Angeles, CA 90069.
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Great War at Sea Airships
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Great War at Sea Airships Product Description
Airships expands on the popular Zeppelins supplement to the Great War at Sea series of wargames. The expansion includes 10 scenarios of events that did or could have happened during World War I.
Great War at Sea is played on two maps: operational and tactical. Fleets move on the operational map until contact is made. At that time, ships of the respective fleets are put on the tactical map where the fighting is resolved ship to ship. All capital ships are portrayed, as are squadrons of destroyers. For World War II fans, the Second World War at Sea system uses similar rules. Players who master one system can easily learn the other.
The Great War at Sea system is vast, with many modules available. Each module focuses on a particular theme and provide counters, maps and scenarios to play. There are two types of modules, the core and the supplements. Core games are complete by themselves, with everything needed to play. Supplements expand on the core modules, bringing new scenarios and unit types to the game, but require one or more core module to play.
Airships is not complete by itself, ownership of Jutland, Mediterranean and Zeppelins is required to play. Some scenarios also require US Navy Plan Gold, Sea of Troubles and Dreadnoughts.
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When you need to be well-armed for a battle or secret mission, make sure you can carry as many weapons as possible. The Ready for Battle Double Sword Harness offers a great option for toting two blades with ease and comfort.
Rogues carry many different kinds of weapons, including swords that they brandish at unwitting travelers and enemies. The Rogue Swordholder is an excellent option for keeping your bladed LARP weapon close at hand at all times.
Never leave your sword at home again with the help of this Imperial Swordholder. Guardsmen and fighters within the Imperial family can always be ready to attack or defend when they wear their blade at their hip with this piece.


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Bangkok – what to do and not to do!
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English Cheese Spread
Suzanne Marzano
This is a favorite for snacking. Goes great with crackers and different types breads, pita, bagel bites or pretzel bread.
- 8 oz
- cream cheese, any type
- 15 oz
- cheese wiz
- 5 oz
- old english cheese spread
- 2 Tbsp
- minced onion, rehydrated
1Rehydrated 2 Tbs minced onions in 2 Tbs warm water or use 4 Tbs. fresh minced onion.
2Let cream cheese warm to room temp.
3Combine all ingredients in deep mixing bowl and beat with electric hand mixer.
4Mixture will be spread consistency, place in bowl and serve with crackers or breads. Also good for celery sticks, and as pretzel dip.
About this Recipe
Course/Dish: Cheese Appetizers
Main Ingredient: Dairy
Regional Style: American
Other Tag: Quick & Easy


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Tuesday, January 17, 2012
She didn't make it!
14 comments:
Dear Linda,
I'm sorry to hear about Miss Millie :( :( :( She really was a beautiful hen :)
wow, that's so cool that you are making more things from scratch at the college kitchen. I think "made from scratch" always tastes better...and everyone will really like the food even more ;) :) That's great...and it's nice that it's making your boss very happy :) :)
Love and hugs from the ocean shores of California, Heather :) :)
p.s. My precious Dad left the hospital this morning, and is now at the VA facility. He's going to get top-notch physical, occupation and speech therapy :) :) Thanks for all your prayers. I'm praying he can come home soon.Sorry to hear about Miss Milly. We usually leave our chickens in their houses until late afternoon or evening depending on the weather, etc. The last few years our chickens have mostly died from natural causes. Our dogs have been good about keeping predators away.
And you also share some of that education with us. What a blessing! I tried one of the chocolate cake recipes you posted a while back, which you had made for your son's anniversary. It was great! Some cake recipes made from scratch I haven't liked. If you have a good yellow cake from scratch that you like, I'd love to have the recipe.
Love, Michelle
Thank you so much for stopping by and leaving me a comment. It is so appreciated and it makes me feel like I am making a new friend.
God Bless your day!


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I can't remember if I altered this one or not. I think I did all the nutcrackers, but didn't include all the frill around it. This one is also at my parents house, big surprise! I think they have some nutcrackers, but that is one thing my Dad didn't go overboard collecting.
Thursday, 30 September 2010
1993 Nutcrackers
Monday, 27 September 2010
1997 Daryl
So I found this one tucked away in a drawer. I had made it for my nephew, who is now 14! I showed it to him and he thought it was cute, but I'm pretty sure he's not going to want this hanging on his wall. Oh well, maybe he'll have a son and name him Daryl too!
Wednesday, 22 September 2010
1992 Woodsy Father Christmas
Sunday, 19 September 2010
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When you get to the end of the 'Hoppy TrAle' you'll find yourself at the Alton Sports Tap on College and Homer Adams Parkway – because that is the only place you will find the Ridgebrook Brewery's new IPA. Tonight February 28, 2013 is the debut of the brew at AST so locals shouldn't miss the unique opportunity to be the first and only to enjoy the dream come true for local brewers Brian and Sarah Keith. Once momentum builds, the plan is to get product out to more establishments, but until then, you'll have an exclusive chance to taste the Keith's dream come true. Party starts at 7:00; t-shirts and glasses will be for sale.
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There have been mixed reactions about the Maserati Kubang concept that bared its sheetmetal at this year's Frankfurt Show last month. Some have been over the luxury SUV's design, the idea of a Maserati SUV being built in the first place, or the fact that the Italian vehicle would be built in the U.S. But most don't seem too crazy about its name, either.
The Kubang carries its name from the first Maserati SUV concept that was introduced at the 2003 Detroit Auto Show, but that may soon change. Cars UK is reporting the automaker has filed a patent application in Europe for the name, "Cinqueporte," which translates to five doors. If you put the pieces of the puzzle together, this could imply the name is for the SUV – unless the Trident label has something else up its sleeve.
Although it may be a tongue-twister, Cinqueporte would be a more fitting name for the SUV, considering there is also the Quattroporte, as well as being more recognizably Italian. Despite critics charges it won't be a "true" Maserati because of plans to build it in Michigan, it will keep true to its roots in at least one area: The engine is promised to be exclusive to the Maserati, and widely believed to be a version of the 4.7-liter V-8 in the Quattroporte, Granturismo and other models. Performance brakes, suspension and steering will also be Modena-engineered.
Which name would you like to see on the Maserati SUV? Kubang, or Cinqueporte?
Source: Cars UK


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Butter Lettuce and Endive with Pomegranate Jewels
Yield | |
Source | newhope360.com/delicious-living.com |
Prep time | 20 minutes |
Cooking time | 30 minutes |
Total time | 50 minutes |
Pomegranate seeds add a wonderful flavor and color to this salad. Not sure how to seed a pomegranate? Check out our pomegranate "how-to" guide.
lettuce, butter (torn into pieces) 3
Belgian endive (cut into 1/4 inch rounds) 1
radicchio (small, finely sliced) 1/2 cup
pomegranate (seeds, or more to taste) 4 ounces
cheese, goat (such as Vermont Creamery cranberry orange and cinnamon) 2 tablespoons
walnut oil, toasted (or olive oil) 1 tablespoon
lemon juice (fresh) 2 tablespoons
orange juice (fresh) 1 teaspoon
Mix the walnut oil, lemon zest, orange zest, lemon juice, orange juice, and honey, plus salt and pepper to taste, in a blender to emulsify. Combine lettuce, endive, and radicchio in a bowl. Toss with the dressing. Transfer to a platter and sprinkle with pomegranate seeds and goat cheese on top.
Export to:- Plain Text
- recipeML


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Tag Archives: green IT
Google Instant Search and energy savings
Google Instant Search ? Since mid September, Google has added a new feature in its search engine : "Google Instant Search" ; this feature updates the search results in Google while you are typing your query. I am not going … Continue reading


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Give us a call to get our secret deals 1-800-468-3578
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When you stay at The Cliff Beach And Spa in Obzor, you'll be by the sea and within the vicinity of Calimera Beach. This 4-star hotel is within the region of Dinevi Marina and Sunny Beach.
Make yourself at home in one of the 79 air-conditioned rooms featuring minibars and flat-screen televisions. Rooms have private balconies. Complimentary wired and wireless Internet access keeps you connected, and satellite programming provides entertainment. Private bathrooms with bathtubs or showers feature designer toiletries and hair dryers.
Relax at the full-service spa, where you can enjoy massages, body treatments, and facials. If you're looking for recreational opportunities, you'll find an outdoor pool, an indoor pool, and a spa tub. Additional amenities at this hotel include complimentary wireless Internet access, wedding services, and a television in a common area.
Enjoy a satisfying meal at a restaurant serving guests of The Cliff Beach And Spa. Relax with your favorite drink at a bar/lounge or a poolside bar. A complimentary breakfast is included.
Business, Other Amenities
Featured amenities include complimentary high-speed (wired) Internet access, a business center, and limo/town car service. Event facilities at this hotel consist of conference space and meeting rooms. A roundtrip airport shuttle is available for a surcharge.
You must present a photo ID when checking in. Your credit card is charged at the time you book. Bed type and smoking preferences are not guaranteed.Your reservation is prepaid and is guaranteed for late arrival. The total charge includes all room charges and taxes, as well as fees for access and booking. Any incidental charges such as parking, phone calls, and room service will be handled directly between you and the property.


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Equity Research experts reviewing imminent earnings progress for BT Group plc (NYSE:BT), are predicting firm to report $0.5 for the quarter completing on 2016-12-31. This number is on a decided basis of the advisors delivering forecasts on the firm.
In analyzing the expert's continuing EPS projections developments, mean prediction is $4.05.
Three months before, the growth estimate was $4.05, on a consensus level. Virtually 1 analysts are covering BT Group plc (NYSE:BT). The consensus point stands at $33.31. The brokers sighting positive up move has target of $33.31, while the conservative projection is $33.31.
This figures may either surpass or miss consensus predictions, which divulge the economic state of a corporation. No matter what the result it, the equity price tends to reacts after release of report. If the released EPS manages to beat the projected target, it comes as a positive surprise, which can result in upward momentum in the stock price. If the posted earnings are not par with the consensus, the impact on stock prices is negative.
A corporation that has an exciting track record of beating consensus EPS predictions will generally grow well in imminent period. Pre-Announcements are forecasts conveyed by entities that offer a clue to stockholders of what their imminent performance will possibly be. These digits are archetypally defined in the contracted range, in which the earnings will likely fall.
To the mark that the average of this released series is noticeably dissimilar than the existing EPS forecast, this announcement type will be detailed a pre-announcement surprise. Fresh research has discovered that pre-announcement revelations regularly have a superior short-term impact on shares price than successive released earnings revelations.
BT Group plc has a rating of 2 based on the outlook of 1 firms. For the period ending 2016-12-31, report can come around 2017-01-27.
The company posted EPS of $0.47 on 2016-10-27 for the quarter ended 2016-09-30. This was a 11.9% surprise factor, or $0.05 away from analysts target.


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Understanding the complex regulation of beta-globin genes is critically important to design therapeutic approaches to beta-thalassemia and sickle cell disease. We have shown that a complex of erythroid proteins GATA-1, LMO2 and TAL1 as well as the more widely expressed nuclear factor Ldb1 mediates beta-globin gene looping to the distant locus control region (LCR) enhancer, which is required for transcription activation. Dimerization of Ldb1 was required for looping and beta-globin transcription rescue in the background of Ldb1 knock down erythroid cells. Deletion of a small conserved region within the dimerization domain yields an Ldb1 mutant protein that can dimerize and rescue long-range LCR/beta-globin looping but is unable to rescue RNA pol II occupancy or beta-globin gene expression. This result indicates that looping does not require transcription. We are studying the functions of this small domain. ChIP experiments now suggest the necessity of this small region for SWI/SNF, NuRD and FOG1 recruitment. Using RNA-seq, Ldb1-dependent genes sensitive and insensitive for loss of this region have been identified. The results so far suggest that in addition to establishing long-range interactions, Ldb1 serves as transcription activator. The insulator binding protein CTCF is also known to be involved in long range interaction at several different loci, primarily as an enhancer blocker. We found that CTCF and LDB1 are cooperatively involved in chromatin loop formation and gene transcription activation at the Ldb1-dependent carbonic anhydrase 2 (CA2) gene. By performing 3C, we observed that intergenic LDB1 binding sites interact with the CA2 promoter which is a CTCF binding site. Enhancer activity of the intergenic sites was confirmed by dual-luciferase assay and enhancer deletion assay using the CRISPR-Cas system. To verify this interaction we performed dual cross-linking ChIP and showed LDB1 occupancy at CTCF sites and vice versa. CA2 is strongly down-regulated by knockdown of either LDB1 or CTCF in mouse erythroid leukemia (MEL) cells. We are studying the domains of LDB1 and CTCF required for their interaction. These experiments suggest that LDB1 and CTCF can cooperate directly in chromatin loop formation and gene transcription. The principles underlying the architectural landscape of chromosomes in living cells remain largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional conformation of a 1 Mbp region of human chromosome 11 containing the beta-globin genes by integrating looping interactions of the insulator protein CTCF determined comprehensively by 3C into a polymer model of chromatin folding . Knock down of CTCF showed that regional CTCF contacts in mammalian nuclei functionally affect spatial distances between globin genes and their control elements and, hence, contribute to chromosomal reorganization required for transcription. We are using Talens to delete CTCF sites with strong 3C interaction frequencies in erythroid cells and testing the effect on globin gene expression and interaction frequencies of the remaining CTCF sites. The predictive nature of the polymer model will be tested with the new data.
Yun, Won Ju; Kim, Yea Woon; Kang, Yujin et al. (2014) The hematopoietic regulator TAL1 is required for chromatin looping between the ?-globin LCR and human ?-globin genes to activate transcription. Nucleic Acids Res 42:4283-93 |
Krivega, Ivan; Dale, Ryan K; Dean, Ann (2014) Role of LDB1 in the transition from chromatin looping to transcription activation. Genes Dev 28:1278-90 |
Li, LiQi; Freudenberg, Johannes; Cui, Kairong et al. (2013) Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood 121:4575-85 |
Kim, Shin-Il; Bultman, Scott J; Kiefer, Christine M et al. (2009) BRG1 requirement for long-range interaction of a locus control region with a downstream promoter. Proc Natl Acad Sci U S A 106:2259-64 |
Hou, Chunhui; Zhao, Hui; Tanimoto, Keiji et al. (2008) CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A 105:20398-403 |