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|By Business Wire
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|January 24, 2013 12:01 AM EST
Overture, the preferred Carrier Ethernet edge and aggregation partner for service providers and network operators worldwide, today announced a partnership agreement with CLAdirect to further enhance business development and customer support in Latin America and the Caribbean. CLAdirect is headquartered in Miami, FL, with local offices in Argentina, Chile, Colombia, Ecuador, Guatemala, Mexico, Panama, Peru, Puerto Rico, Dominican Republic and Venezuela, providing customers throughout the region with solutions such as network management and optimization, applications and network security.
"Overture is a leading innovator in Carrier Ethernet, and our association is a significant step to more easily meet the growing demands for Ethernet solutions in the markets we serve," said Gerardo Lacunza, CLAdirect's director of solutions. "This partnership is critical to offering our customers a set of proven solutions that will enhance their businesses and allow them to be more competitive and successful."
With this agreement, CLAdirect will represent Overture's entire portfolio, including edge and aggregation solutions for Ethernet over fiber, copper, TDM and SDH systems and management software.
"CLAdirect has established an outstanding professional reputation in Latin America and the Caribbean which has led to our partnership agreement," said Mario Velez, Overture vice president of Sales, CALA. "This collaboration will be instrumental in bringing our innovative Carrier Ethernet solutions to the growing customer base in the region so that they can monetize new business services and streamline their operations."
For information about Overture, please visit www.overturenetworks.com or follow @OvertureNews on Twitter.
About CLAdirect
CLAdirect is a Technology Solutions Provider specialized in telecommunications and utilities verticals. With a highly qualified group of professionals and knowledge of market needs in the countries of Latin America and the Caribbean, the company provides solutions that include Managed Services, Professional Services, Logistics Services, and Local Services. CLAdirect works with Technology and Business Partners to satisfy customer needs and identify new opportunities, providing value through the delivery of products, solutions and services that enhance the development of our business partners. CLAdirect is a network of companies with presence through local offices in Argentina, Chile, Colombia, Dominican Republic, Ecuador, Guatemala, Mexico, Panama, Peru, Puerto Rico, USA and Venezuela, providing customers throughout the region with solutions such as network management and optimization, applications and network security. For more information, visit http://www.cladirect.com
About Overture Networks
Overture is the preferred Carrier Ethernet edge and aggregation partner to hundreds of service providers and network operators worldwide. By providing an entrance to a smarter network, service providers can leverage Carrier Ethernet to multiply revenue and streamline operational costs by enabling high-capacity Ethernet services over any physical media, including fiber, copper and TDM. Overture's solutions are designed for reliability and ease of use, and arm customers to compete in demanding applications such as cloud computing and mobile communications that require greater bandwidth and smarter networks. Overture is headquartered in Research Triangle Park, NC, with offices around the globe. For more information, visit http://www.overturenetworks.com.
SYS-CON Events announced today that IBM has been named "Diamond Sponsor" of SYS-CON's 21st Cloud Expo, which will take place on October 31 through November 2nd 2017 at the Santa Clara Convention Center in Santa Clara, California.
Jun. 23, 2017 09:30 PM EDT Reads: 537
When growing capacity and power in the data center, the architectural trade-offs between server scale-up vs. scale-out continue to be debated. Both approaches are valid: scale-out adds multiple, smaller servers running in a distributed computing model, while scale-up adds fewer, more powerful servers that are capable of running larger workloads. It's worth noting that there are additional, unique advantages that scale-up architectures offer. One big advantage is large memory and compute capacity...
Jun. 23, 2017 09:00 PM EDT Reads: 1,441
In his session at @ThingsExpo, Eric Lachapelle, CEO of the Professional Evaluation and Certification Board (PECB), provided an overview of various initiatives to certify the security of connected devices and future trends in ensuring public trust of IoT. Eric Lachapelle is the Chief Executive Officer of the Professional Evaluation and Certification Board (PECB), an international certification body. His role is to help companies and individuals to achieve professional, accredited and worldwide re...
Jun. 23, 2017 07:00 PM EDT Reads: 1,292
With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend 21st Cloud Expo October 31 - November 2, 2017, at the Santa Clara Convention Center, CA, and June 12-14, 2018, at the Javits Center in New York City, NY, and learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation.
Jun. 23, 2017 05:00 PM EDT Reads: 909
No hype cycles or predictions of zillions of things here. IoT is big. You get it. You know your business and have great ideas for a business transformation strategy. What comes next? Time to make it happen. In his session at @ThingsExpo, Jay Mason, Associate Partner at M&S Consulting, presented a step-by-step plan to develop your technology implementation strategy. He discussed the evaluation of communication standards and IoT messaging protocols, data analytics considerations, edge-to-cloud tec...
Jun. 23, 2017 04:00 PM EDT Reads: 936
Amazon started as an online bookseller 20 years ago. Since then, it has evolved into a technology juggernaut that has disrupted multiple markets and industries and touches many aspects of our lives. It is a relentless technology and business model innovator driving disruption throughout numerous ecosystems. Amazon's AWS revenues alone are approaching $16B a year making it one of the largest IT companies in the world. With dominant offerings in Cloud, IoT, eCommerce, Big Data, AI, Digital Assista...
Jun. 23, 2017 02:00 PM EDT Reads: 1,151
SYS-CON Events announced today that CA Technologies has been named "Platinum Sponsor" of SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. CA Technologies helps customers succeed in a future where every business - from apparel to energy - is being rewritten by software. From planning to development to management to security, CA creates software that fuels transformation for companies in the applic...
Jun. 23, 2017 01:45 PM EDT Reads: 383
Artificial intelligence, machine learning, neural networks. We're in the midst of a wave of excitement around AI such as hasn't been seen for a few decades. But those previous periods of inflated expectations led to troughs of disappointment. Will this time be different? Most likely. Applications of AI such as predictive analytics are already decreasing costs and improving reliability of industrial machinery. Furthermore, the funding and research going into AI now comes from a wide range of com...
Jun. 23, 2017 01:45 PM EDT Reads: 1,284
Multiple data types are pouring into IoT deployments. Data is coming in small packages as well as enormous files and data streams of many sizes. Widespread use of mobile devices adds to the total. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists looked at the tools and environments that are being put to use in IoT deployments, as well as the team skills a modern enterprise IT shop needs to keep things running, get a handle on all this data, and deliver...
Jun. 23, 2017 01:30 PM EDT Reads: 384
Internet of @ThingsExpo, taking place October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 21st Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devic...
Jun. 23, 2017 12:45 PM EDT Reads: 1,246
SYS-CON Events announced today that Cloud Academy named "Bronze Sponsor" of 21st International Cloud Expo which will take place October 31 - November 2, 2017 at the Santa Clara Convention Center in Santa Clara, CA. Cloud Academy is the industry's most innovative, vendor-neutral cloud technology training platform. Cloud Academy provides continuous learning solutions for individuals and enterprise teams for Amazon Web Services, Microsoft Azure, Google Cloud Platform, and the most popular cloud com...
Jun. 23, 2017 12:30 PM EDT Reads: 880
SYS-CON Events announced today that Enzu will exhibit at SYS-CON's 21st Int\ernational Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Enzu's mission is to be the leading provider of enterprise cloud solutions worldwide. Enzu enables online businesses to use its IT infrastructure to their competitive advantage. By offering a suite of proven hosting and management services, Enzu wants companies to focus on the core of their ...
Jun. 23, 2017 11:15 AM EDT Reads: 1,509
We build IoT infrastructure products - when you have to integrate different devices, different systems and cloud you have to build an application to do that but we eliminate the need to build an application. Our products can integrate any device, any system, any cloud regardless of protocol," explained Peter Jung, Chief Product Officer at Pulzze Systems, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA
Jun. 23, 2017 11:00 AM EDT Reads: 1,120
SYS-CON Events announced today that GrapeUp, the leading provider of rapid product development at the speed of business, will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Grape Up is a software company, specialized in cloud native application development and professional services related to Cloud Foundry PaaS. With five expert teams that operate in various sectors of the market acr...
Jun. 23, 2017 10:45 AM EDT Reads: 1,612
SYS-CON Events announced today that Ayehu will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on October 31 - November 2, 2017 at the Santa Clara Convention Center in Santa Clara California. Ayehu provides IT Process Automation & Orchestration solutions for IT and Security professionals to identify and resolve critical incidents and enable rapid containment, eradication, and recovery from cyber security breaches. Ayehu provides customers greater control over IT infras...
Jun. 23, 2017 10:30 AM EDT Reads: 1,697
SYS-CON Events announced today that MobiDev, a client-oriented software development company, will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. MobiDev is a software company that develops and delivers turn-key mobile apps, websites, web services, and complex software systems for startups and enterprises. Since 2009 it has grown from a small group of passionate engineers and business...
Jun. 23, 2017 10:15 AM EDT Reads: 1,623
In his session at Cloud Expo, Alan Winters, an entertainment executive/TV producer turned serial entrepreneur, presented a success story of an entrepreneur who has both suffered through and benefited from offshore development across multiple businesses: The smart choice, or how to select the right offshore development partner Warning signs, or how to minimize chances of making the wrong choice Collaboration, or how to establish the most effective work processes Budget control, or how to ma...
Jun. 23, 2017 07:15 AM EDT Reads: 1,631
"When we talk about cloud without compromise what we're talking about is that when people think about 'I need the flexibility of the cloud' - it's the ability to create applications and run them in a cloud environment that's far more flexible," explained Matthew Finnie, CTO of Interoute, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
Jun. 23, 2017 05:00 AM EDT Reads: 1,734
IoT solutions exploit operational data generated by Internet-connected smart "things" for the purpose of gaining operational insight and producing "better outcomes" (for example, create new business models, eliminate unscheduled maintenance, etc.). The explosive proliferation of IoT solutions will result in an exponential growth in the volume of IoT data, precipitating significant Information Governance issues: who owns the IoT data, what are the rights/duties of IoT solutions adopters towards t...
Jun. 23, 2017 12:30 AM EDT Reads: 1,381
With the introduction of IoT and Smart Living in every aspect of our lives, one question has become relevant: What are the security implications? To answer this, first we have to look and explore the security models of the technologies that IoT is founded upon. In his session at @ThingsExpo, Nevi Kaja, a Research Engineer at Ford Motor Company, discussed some of the security challenges of the IoT infrastructure and related how these aspects impact Smart Living. The material was delivered interac...
Jun. 23, 2017 12:15 AM EDT Reads: 1,162


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Mebane Park Surgery Center Names New Director
Ms. Bryant will be responsible for administration and clinical operations at the center, according to a report from the Times-News.
Most recently, she was the director of operative services at the Women's Hospital in Greensboro, N.C., according to the report.
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- Valeant's Bausch + Lomb contact lens solutions brand most trusted in Canada — 3 key notes

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Im On Recess - Enjoy our growing selection of fun games, images and videos.
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Dicey Mice is a poker style dice game based on the ancient game Knucklebones. Easy and Fun for everyone, but getting top scores will require some strategy.
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News In Britain Online
Arkansas Tent Rental
Little Rock AR. 72212 US
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Tamil actress Vidyu Raman became a name to reckon with after the success of her last two films Raju Gari Gadhi and Sarrainodu. Vidyu's dialogue delivery and comedy timing were widely appreciated.
Latest update reveals that this talented actress will soon be hosting a Telugu television show Drama Juniors along with hotshot anchor Pradeep Machi Raju. Vidyu has currently some very interesting projects lined up in Telugu and is looking to consolidate her position in Tollywood.
- Will Rajamouli Ever Do A Film With Pawan Kalyan?
- Sunil's next progressing in Florida
- Nag's RGG 2 gets a tentative release date
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Homestays and room rental in Little Venice, London
We have found 8 homestays in Little Venice, London for your stay. Renting a room with Homestay in Little Venice offers host family accommodation, ideal for all types of travel including tourists, students, gap year, interns or city break weekenders.
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North Chicago, IL6/29/2017
Online6/29/2017 - 10/16/2017
RAPS Virtual Career Fairs are designed to connect employees with employers no matter where they might be located.
Local or global—RAPS has you covered with offices in Washington, DC, Shanghai and Singapore. There are RAPS chapters in Canada, Israel, Switzerland, Taiwan and throughout the United States, and local networks in Australia, Belgium, Brazil, Germany, India, Mexico, The Netherlands, Poland and Singapore.
Regulatory Exchange, aka RegEx, is where members come online to learn, grow and engage with a diverse global community of regulatory professionals with similar interests and goals.
It's well-known that the National Institutes of Health (NIH) offers billions of dollars in grants to US academic research facilities. What's less well-known is that each year, hundreds of new inventions are produced in the laboratories of NIH, the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA), and these inventions are licensed out to private companies in the US and internationally for further research and development, with the hopes of bringing new products to market.
With a new Texas law now in the books to allow companies to sell unproven stem cell treatments without US Food and Drug Administration (FDA) approval, some experts wonder when FDA will step in to shut down companies and clinics exposing people to unapproved medical products.
The US Food and Drug Administration's (FDA) Center for Biologics Research and Evaluation (CBER) on Wednesday released its annual summary of manufacturing deviations reported by biologics, blood and blood component, and human cells, tissues, and cellular and tissue-based products (HCT/P) manufacturers.
The US Food and Drug Administration (FDA) on Wednesday issued a revised draft guidance detailing the current good manufacturing practice (cGMP) requirements for medical gases, superseding an earlier draft guidance from 2003.
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This article provides insight into Conditional Approvals (CAs) and Conditional Marketing Approvals (CMAs) as developed across several jurisdictions to potentially provide earlier access to new medicines. The author explains the specifics regarding regulatory requirements for obtaining CAs in the European Union (EU), Japan and the US.
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Tags: Conditional approval, Regenerative medicine
Peter Marks, director of the US Food and Drug Administration's (FDA) Center for Biologics Evaluation and Research (CBER) on Thursday said his office is equipped to support the development of cutting edge treatments, such as cell and gene therapies.
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The Senate on Wednesday passed the 21st Century Cures Act by a vote of 94-5. President Barack Obama praised the bipartisan efforts and said he will sign the bill.
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Tags: Gene therapy, Cell therapy, Regenerative medicine, Advances therapies, Senator Tammy Baldwin, Michael Werner
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Tags: Regenerative Medicine, Cures Acceleration Network, CAN, Legislation, Latest News, regulatory science, Bill


text: Stayed for 3 nights for business as had a two day course to run. Flight was delayed 6 hours so was late at night when arrived. Just called hotel and they came out immediately to pick myself and two others up. They have complimentary airport pickup and delivery available which was great. Staff. All staff have been helpful and accommodating.... More


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Dr. George Brooks DO Patient Reviews
- Family Medicine Knoxville, TN
Overall Rating
30 Patient Reviews
- Wait Time 13 minutes
- Easy Appointments
- Promptness
- Friendly Staff
- Fair and Accurate Diagnosis
- Bedside Manner
- Spends Time With Patients
- Appropriate Followup
Showing 1 - 12 reviews
4.0 of 5
March 22nd, 2016
Pain Medication
Dr.Brooks writes pain medicines 3 months in advance not requiring the patient to come back in office each month for a pill count or drug screen. If you looking for a Dr. to just give you pain meds you have found him. I had such a hard time getting a doctor to write multiple prescriptions. no one wanted to write for 2 pain meds and Xanax at the same time but he did. I get morphine,hydros,phenergan and Xanax.
1.0 of 5
June 27th, 2014
It says that they are accepting new patients, so I called Friday at 1:30 to make an appointment. The recording says that they do not close until 2, yet the calls kept going to a recording saying to wait on hold for a physician. I did this in hopes of making an appointment for monday, yet I stayed on hold waiting for 15 minutes and nobody picked up the phone. Horrible customer service if you ask me, why would you stop answering calls a half an hour before you are closed?
5.0 of 5
October 28th, 2013
Dr. Brooks best DR.
We have had Dr. Brooks for our primary Dr. for the last twelve years. He has always listened carefully and gave his best to me and my husband. We highly recommend him. He sent my husband to a specialist after seeing his psa was a little high. Saving him from Prostrate cancer as he was positive on the biopsy. He made sure I got an ultra sound on a my thyroid after locating a large nodule. Thanks to him we are doing well for his being on top of things with us. Thanks Dr. Brooks!
5.0 of 5
April 15th, 2013
We love Dr. Brookes. My father is in very poor health, and see's Dr. Brookes. He has a wonderful bedside manner, and does all he can to make my father feel the best he can, and manage it disease.
5.0 of 5
April 25th, 2017
4.0 of 5
December 21st, 2016
4.0 of 5
January 14th, 2016
5.0 of 5
December 21st, 2015
5.0 of 5
December 21st, 2015
5.0 of 5
September 21st, 2015
5.0 of 5
August 17th, 2015
5.0 of 5
July 22nd, 2015
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Trailer Rental & Towing in Vidalia, GA at Deans Tire & Service Center Inc
Moving to or from Vidalia, GA? U-Haul cargo and enclosed trailers are intelligently designed to protect and secure your precious belongings, while our open utility trailers are perfect for hauling building supplies, landscaping materials or bulky items. U-Haul car trailers have EZ load ramps for effortless loading of vehicles while our motorcycle trailers are lightweight and easy to tow. Get FREE trailer rental rate quotes in Vidalia GA 30474 today.
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Customer Reviews
Steven M. on
Tried to drop off the truck at two other locations before using Deans. First location the lot was full and the second location a convenience store I was told they were not taking returns on Saturday.
Dana L. on
Very clean and professional. You can count on this place being open and ready to help you.
Molly M. on
I reserved a 10ft truck to be picked up in Hazlehurst Ga on 8/7/16. When we arrived for pickup the truck was not there. We had to drive to Vidalia to picked up the truck and the inconvenience for this really was unacceptable. Uhaul needs to pay better attention to their reservations.
ROBERT M. on
Dispatch related concern, not local dealer : made on-line reservation for a 20 ft truck several weeks in advance, but during the actual rental week I was told only options from any area dealers was to get a 15' or 26'. 15' is way too small so I had to settle for 26' truck which was way too big for my need.
Guy H. on
Need closer locations to Dublin, Ga. Too far to drive and then had to pay extra miles.


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Turner's clear and easy-to-follow manual has made the professional skills of Cockpit Resource Management (CRM) available to the private pilot for the first time. CRM enables pilots to greatly improve their decision making, risk recognition and management, hazardous-attitudes awareness, and flight-phase goal development, and to decrease the likelihood of pilot error. Second edition, fully updated, with latest regulations and accident statistics.
"synopsis" may belong to another edition of this title.
Professional CRM techniques customized for single-pilot operations! Cockpit Resource Management: The Private Pilot's Guide is the first manual to transfer lifesaving CRM techniques to the private pilot/single operator environment, showing you how to: handle distractions; recognize and circumvent potential emergency situations; reduce cockpit workload; be aware of hazardous attitudes; sharpen your judgment; improve decision-making skills; increase situational awareness. The key says Turner, is toset realistic goals for each flight, and to prioritize these goals to maximize safety. Step by step, Turner demonstrates how, through a clear and logical presentation of CRM skills and techniques, from preflight to landing. Case studies provide vivid examples of CRM in action. This fully updated second edition includes the latest safety regulations and accident studies, recent and pending changes in regulations, and a greatly expanded teaching chapter.
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Book Description Mcgraw-Hill, 1995. Hardcover. Book Condition: New. book. Bookseller Inventory # 70656037
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Sold as pack of 2
Our scoops are aluminium and measure 19cm in length, the scoop is 6cm wide.
They can be used to scoop confetti petals from baskets or jars.
Or can be used to scoop sweets from jars for a candy buffet.
Sold as a set of 2.
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Explore January 29, Rain and more!
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winter rain by Miklós Bodó #fineartphotography #photography
'Skyforger' January 29 2017 Song: #Amorphis - Sky Is Mine #vlogdave #youtuber #photography #fotografie #photographer #photographyislife #nature #sky #skyporn #beautiful #architecture #panorama #scenery #perspective #angle #colors #colorful #bluesky #clouds #dreamy #instadaily #instagood #instapic #picoftheday #diewocheaufinstagram
Paris couturier Paco Rabanne presents a long-sleeved minidress of black and white plastic discs revealing the upper torso in his spring and summer collection in Paris, France, on January 29, 1969. (AP Photo)
Light sculptures depicting ducks are seen during a photocall to promote the Magical Lantern Festival at Chiswick House Gardens in west London on January 29, 2016. The festival, to celebrate Chinese New Year 2016 - the Year of the Monkey, uses more than 50 hand-sculpted lanterns and is set to run from Febuary 3 to March 6, 2016. / AFP / JUSTIN TALLIS
Alessia Ventura attends Alessandro Martorana's birthday party on January 29, 2015 in Milan, Italy.
Gloria Serra attends 'Antena 3' 25th Anniversary Reception at the Palacio de Cibeles on January 29, 2015 in Madrid, Spain.
Algerian War of Independence, Frontpage of the newspaper El Moudjahid (newspaper of the National Liberation Front), January 29, 1961, pin by Paolo Marzioli
Sara Gilbert (born Sara Rebecca Abeles; January 29, 1975) is an American actress, best known for her role as Darlene Conner on the ABC sitcom Roseanne from 1988 to 1997, as co-host and creator of the daytime talk show The Talk and for her recurring role as Leslie Winkle on CBS's The Big Bang Theory. A Magna Cum Laude graduate of Yale University, with a degree in art.
Indian President Pranab Mukherjee arrives on a horse carriage, reviving a presidential tradition discontinued for 30 years, during the Beating Retreat Ceremony at Vijay Chowk in New Delhi on January 29, 2014. The ceremony is a culmination of Republic Day celebrations and dates back to the days when troops disengaged themselves from battle at sunset.
A model walks the runway during the Zuhair Murad show as part of Paris Fashion Week Haute Couture Spring/Summer 2015 at Palais de Tokyo on January 29, 2015 in Paris, France.


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Epithelial mesenchymal transition (EMT), a spectrum of states: role in lung development, homeostasis and disease.
Epithelial Mesenchymal Transition (EMT) plays key roles during lung development and many lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), lung cancer and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e. often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix-producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. This article is protected by copyright. All rights reserved.
Item usage in a multidimensional computerized adaptive test (MCAT) measuring health-related quality of life.
Examining item usage is an important step in evaluating the performance of a computerized adaptive test (CAT). We study item usage for a newly developed multidimensional CAT which draws items from three PROMIS domains, as well as a disease-specific one.
Why do physicians lack engagement with smoking cessation treatment in their COPD patients? A multinational qualitative study.
Smoking cessation is the only effective intervention to slow down the accelerated decline in lung function in smokers with chronic obstructive pulmonary disease. Nevertheless, physicians often do not routinely provide evidence-based smoking cessation treatment to their patients. To understand underlying reasons, we explored how physicians engage in smoking cessation treatment in their chronic obstructive pulmonary disease patients. In total, 21 focus group discussions were held with general practitioners and pulmonologists in seven different countries in Europe and Asia. We generated three themes, whereby some of the issues concerned smokers in general: first, 'physicians' frustration with chronic obstructive pulmonary disease patients who smoke'. These frustrations interfered with the provision of evidence-based treatment and could result in this group of patients being treated unequally. Second: 'physicians' limited knowledge of, and negative beliefs about, smoking cessation treatment'. This hindered treating smokers effectively. Third: 'healthcare organisational factors that influence the use of smoking cessation treatments'. Money and time issues, as well as the failure to regard smoking as a disease, influenced how physicians engaged in smoking cessation treatment. Our results indicate that there is a number of barriers to the provision of effective smoking cessation treatment in patients with chronic obstructive pulmonary disease and smokers in general. Introducing an informative smoking cessation programme, including communication skills and ethical issues, in the vocational and postgraduate medical training may help to address these barriers. This is important in order to increase engagement with smoking cessation treatment and to improve quality of chronic obstructive pulmonary disease care.
Association between chronic obstructive pulmonary disease and increased risk of benign prostatic hyperplasia: a retrospective nationwide cohort study.
Chronic obstructive pulmonary disease (COPD) and benign prostatic hyperplasia (BPH) are common disorders in ageing male populations. Nevertheless, the relationship between the two diseases has rarely been explored. The objective of this study was to examine whether patients with COPD are at an increased risk of BPH.
Feasibility of average volume-assured pressure support ventilation in the treatment of acute hypercapnic respiratory failure associated with chronic obstructive pulmonary disease: What are its limits?
Comparative analysis: Effectiveness of nicotine addiction treatment in people with psychiatric comorbidity.
To determine whether or not nicotine addiction treatment was less effective in psychiatric than in the healthy population.
Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial).
Non-dihydropyridine calcium channel blockers (non-DHP CCBs) possess combined P-glycoprotein and moderate CYP3A4 inhibition, which may lead to increased exposure of medications that are substrates for these metabolic pathways, such as rivaroxaban. We evaluated the use and outcomes of non-DHP CCBs in patients with atrial fibrillation (AF) in Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). We assessed clinical outcomes in patients who received non-DHP CCBs and the impact on the efficacy and safety of rivaroxaban compared with warfarin. Stroke or noncentral nervous system (CNS) systemic embolism (SE), major or nonmajor clinically relevant (NMCR) bleeding, all-cause death, and major bleeding were compared according to non-DHP CCB use. At randomization, 1,308 patients (9.2%) were taking a non-DHP CCB. They were more likely to be women, have diabetes and COPD, and less likely to have heart failure and had a lower mean CHADS2 score (3.3 vs 3.5). Non-DHP CCB use was not associated with an increased risk of stroke/non-CNS SE (p = 0.11) or the composite outcome of NMCR or major bleeding (p = 0.087). Non-DHP CCB use was associated with an increased risk of major bleeding (adjusted hazard ratio 1.50, 95% CI 1.11 to 2.04) and intracranial hemorrhage (adjusted hazard ratio 2.84, 95% CI 1.53 to 5.29). No significant difference was observed in the primary efficacy (stroke or non-CNS SE; adjusted interaction p value = 0.38) or safety outcome (NMCR or major bleeding; adjusted interaction p value = 0.14) between rivaroxaban and warfarin with non-DHP CCB use. In conclusion, although the overall use of non-DHP CCBs was associated with an increased risk of major bleeding and intracranial hemorrhage, the use was not associated with a significant change in the safety or efficacy of rivaroxaban compared with warfarin observed in ROCKET AF.
Pulmonary (3)He Magnetic Resonance Imaging Biomarkers of Regional Airspace Enlargement in Alpha-1 Antitrypsin Deficiency.
Thoracic x-ray computed tomography (CT) and hyperpolarized (3)He magnetic resonance imaging (MRI) provide quantitative measurements of airspace enlargement in patients with emphysema. For patients with panlobular emphysema due to alpha-1 antitrypsin deficiency (AATD), sensitive biomarkers of disease progression and response to therapy have been difficult to develop and exploit, especially those biomarkers that correlate with outcomes like quality of life. Here, our objective was to generate and compare CT and diffusion-weighted inhaled-gas MRI measurements of emphysema including apparent diffusion coefficient (ADC) and MRI-derived mean linear intercept (Lm) in patients with AATD, chronic obstructive pulmonary disease (COPD) ex-smokers, and elderly never-smokers.
Healthcare expenditure on Indigenous and non-Indigenous Australians at high risk of cardiovascular disease.
In spite of bearing a heavier burden of death, disease and disability, there is mixed evidence as to whether Indigenous Australians utilise more or less healthcare services than other Australians given their elevated risk level. This study analyses the Medicare expenditure and its predictors in a cohort of Indigenous and non-Indigenous Australians at high risk of cardiovascular disease.
Cardiorespiratory responses of air filtration: A randomized crossover intervention trial in seniors living in Beijing: Beijing Indoor Air Purifier StudY, BIAPSY.
In this Beijing Indoor Air Purifier StudY (BIAPSY), we conducted a randomized crossover intervention trial in a panel of 35 non-smoking senior participants with free-living, with and without chronic obstructive pulmonary disease (COPD). Portable air filtration units were randomly allocated to active-(filter in) for 2weeks and sham-mode (filter out) for 2weeks in the households. We examined the differences in indoor air pollutant concentrations in 20 study homes and a suite of cardio-respiratory biomarker levels in study participants between filtration modes, with and without adjustment for potential confounders. Following active filtration, we observed significant reductions from 60±45 to 24±15μg/m(3) in ten-day averages of indoor PM2.5 and reductions from 3.87±1.65 to 1.81±1.19m(-1).10(-5) in ten-day averages of indoor BC, compared to sham-mode filtration. The major components of indoor PM2.5, including water soluble organics, NO3(-), SO4(2-), Zn(2+), Pb(2+) and K(+), were also reduced significantly by 42% to 63%. However, following active filtration, we only observed significant reductions on systemic inflammation measured as of IL-8 at 58.59% (95% CI: -76.31, -27.64) in the total group of participants and 70.04% (95% CI: -83.05, -47.05) in the subset of COPD patients, with adjustments. We were not able to detect improvements on lung function, blood pressure, and heart rate variability, following short-term intervention of two-week active air filtration. In conclusion, our results showed that indoor air filtration produced clear improvement on indoor air quality, but no demonstrable changes in the cardio-respiratory outcomes of study interest observed in the seniors living with real-world air pollution exposures.
Context Relevant Prediction Model for COPD Domain Using Bayesian Belief Network.
In the last three decades, researchers have examined extensively how context-aware systems can assist people, specifically those suffering from incurable diseases, to help them cope with their medical illness. Over the years, a huge number of studies on Chronic Obstructive Pulmonary Disease (COPD) have been published. However, how to derive relevant attributes and early detection of COPD exacerbations remains a challenge. In this research work, we will use an efficient algorithm to select relevant attributes where there is no proper approach in this domain. Such algorithm predicts exacerbations with high accuracy by adding discretization process, and organizes the pertinent attributes in priority order based on their impact to facilitate the emergency medical treatment. In this paper, we propose an extension of our existing Helper Context-Aware Engine System (HCES) for COPD. This project uses Bayesian network algorithm to depict the dependency between the COPD symptoms (attributes) in order to overcome the insufficiency and the independency hypothesis of naïve Bayesian. In addition, the dependency in Bayesian network is realized using TAN algorithm rather than consulting pneumologists. All these combined algorithms (discretization, selection, dependency, and the ordering of the relevant attributes) constitute an effective prediction model, comparing to effective ones. Moreover, an investigation and comparison of different scenarios of these algorithms are also done to verify which sequence of steps of prediction model gives more accurate results. Finally, we designed and validated a computer-aided support application to integrate different steps of this model. The findings of our system HCES has shown promising results using Area Under Receiver Operating Characteristic (AUC = 81.5%).
Chronic Respiratory Infection in Patients with Chronic Obstructive Pulmonary Disease: What Is the Role of Antibiotics?
Chronic infections are associated with exacerbation in patients with chronic obstructive pulmonary disease (COPD). The major objective of the management of these patients is the prevention and effective treatment of exacerbations. Patients that have increased sputum production, associated with purulence and worsening shortness of breath, are the ones that will benefit from antibiotic therapy. It is important to give the appropriate antibiotic therapy to prevent treatment failure, relapse, and the emergence of resistant pathogens. In some patients, systemic corticosteroids are also indicated to improve symptoms. In order to identify which patients are more likely to benefit from these therapies, clinical guidelines recommend stratifying patients based on their risk factor associated with poor outcome or recurrence. It has been identified that patients with more severe disease, recurrent infection and presence of purulent sputum are the ones that will be more likely to benefit from this therapy. Another approach related to disease prevention could be the use of prophylactic antibiotics during steady state condition. Some studies have evaluated the continuous or the intermittent use of antibiotics in order to prevent exacerbations. Due to increased bacterial resistance to antibiotics and the presence of side effects, several antibiotics have been developed to be nebulized for both treatment and prevention of acute exacerbations. There is a need to design long-term studies to evaluate these interventions in the natural history of the disease. The purpose of this publication is to review our understanding of the role of bacterial infection in patients with COPD exacerbation, the role of antibiotics, and future interventions.
Palliative oxygen for chronic breathlessness: what new evidence?
Supplemental oxygen improves survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxaemia, but the effect of oxygen therapy in mild or moderate hypoxaemia to reduce symptomatic chronic breathlessness remains unclear. This review provides an overview of recent evidence about the role of oxygen therapy for the relief of chronic breathlessness in advanced illness.
Role of Breathing Conditions During Exercise Testing on Training Prescription in Chronic Obstructive Pulmonary Disease.
This study investigated whether different breathing conditions during exercise testing will influence measures of exercise capacity commonly used for training prescription in chronic obstructive pulmonary disease. Twenty-seven patients with chronic obstructive pulmonary disease (forced expiratory volume in 1 sec = 45.6 [9.4]%) performed three maximal exercise tests within 8 days, but at least 48 hrs apart. Subjects were thereby breathing either room air through a tightly fitting face mask like during any cardiopulmonary exercise test (MASK), room air without mask (No-MASK), or 10 l/min of oxygen via nasal cannula (No-MASK + O2). Cycling protocols were identical for all tests (start = 20 watts, increment = 10 males/5 females watts/min). Maximal work rate (90.4 [33.8], 100.3 [34.8], 107.4 [35.9] watts, P < 0.001) and blood lactate at exhaustion (4.3 [1.5], 5.2 [1.6], 5.0 [1.4] mmol/l, P < 0.001) were lowest for MASK when compared with No-MASK and No-MASK + O2, respectively, whereas maximal heart rate did not differ significantly. Submaximal exertion (Borg rating of perceived exertion = 12-14) was perceived at lower intensity (P = 0.008), but higher heart rate (P = 0.005) when MASK was compared with No-MASK and No-MASK + O2. Different breathing conditions during exercise testing resulted in an 18.8% difference in maximal work rate, likely causing underdosing or overdosing of exercise in chronic obstructive pulmonary disease. Face masks reduced whereas supplemental oxygen increased patients' exercise capacity. For accurate prescription of exercise in chronic obstructive pulmonary disease, breathing conditions during testing should closely match training conditions.
More than expectorant: new scientific data on ambroxol in the context of the treatment of bronchopulmonary diseases.
Ambroxol has been established for decades in the treatment of acute and chronic respiratory diseases. In 2015, the European Medicines Agency reassessed the clinical benefit-risk ratio of the drug.
Repair of Thoracoabdominal Aortic Aneurysm with Thrombosed Infrarenal Component: A Modified Hybrid Technique without Aortic Cross Clamping.
The authors report the successful repair of a Crawford type III thoracoabdominal aortic aneurysm (TAAA) with a thrombosed infrarenal component using a modified hybrid technique without aortic clamping in a high-risk patient. A 64-year-old male with a history of hypertension, diabetes, and severe chronic obstructive pulmonary disease presented with acute on chronic backache and bilateral short distance claudication. A computerized tomography scan demonstrated a large, nonleaking Crawford type III TAAA with thrombosed infrarenal component of the aneurysm. In addition, both common iliac arteries were occluded with the chronic thrombus. A single-stage, modified hybrid procedure involving an aortobifemoral bypass without aortic clamping, debranching of right renal, superior mesenteric, and celiac arteries as well as an endovascular repair of the thoracic aneurysm was performed. Unfortunately, despite a technically sound repair, the patient died postoperatively from a massive pulmonary embolism. TAAA with a thrombosed infrarenal aorta and bilateral common iliac arteries can be repaired using a single-stage modified hybrid procedure without aortic clamping in high-risk patients who cannot tolerate thoracotomy and aortic cross clamping.
Prescription opioid use in advanced COPD: benefits, perils and controversies.
Predictors of long-term smoking cessation in patients with COPD: results from a randomised controlled trial.
Aclidinium bromide improves symptoms and sleep quality in COPD: a pilot study.
Prescription opioid use in advanced COPD: benefits, perils and controversies.
Run-in bias in randomised trials: the case of COPD medications.
Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD.Serum from healthy never-smokers (healthy), smokers with normal lung function (smokers), and smokers with COPD (COPD; Global Initiative for Chronic Obstructive Lung Disease stages I-II/A-B) from the Karolinska COSMIC cohort (n=116) was analysed using our nontargeted liquid chromatography-high resolution mass spectrometry metabolomics platform.Pathway analyses revealed that several altered metabolites are involved in oxidative stress. Supervised multivariate modelling showed significant classification of smokers from COPD (p=2.8×10(-7)). Sex stratification indicated that the separation was driven by females (p=2.4×10(-7)) relative to males (p=4.0×10(-4)). Significantly altered metabolites were confirmed quantitatively using targeted metabolomics. Multivariate modelling of targeted metabolomics data confirmed enhanced metabolic dysregulation in females with COPD (p=3.0×10(-3)) relative to males (p=0.10). The autotaxin products lysoPA (16:0) and lysoPA (18:2) correlated with lung function (forced expiratory volume in 1 s) in males with COPD (r=0.86; p<0.0001), but not females (r=0.44; p=0.15), potentially related to observed dysregulation of the miR-29 family in the lung.These findings highlight the role of oxidative stress in COPD, and suggest that sex-enhanced dysregulation in oxidative stress, and potentially the autotaxin-lysoPA axis, are associated with disease mechanisms and/or prevalence.
Long-term volume-targeted pressure-controlled ventilation: sense or nonsense?
The technology underlying the development of novel ventilatory modes for long-term noninvasive ventilation of patients with chronic hypercapnia is continuously evolving. Volume-targeted pressure-controlled ventilation is a hybrid ventilation mode designed to combine the advantages of conventional ventilation modes, while avoiding their drawbacks. However, manufacturers have created different names and have patented algorithms and set-up variables, which can result in confusion for physicians and respiratory therapists. In addition, clear evidence for the superiority of this novel mode has not yet been established. These factors have most likely hindered more widespread use of this mode in clinical practice. The current review presents the rationale, working principles, characteristics and set-up recommendations associated with volume-targeted modes. In addition, it summarises the clinical and laboratory studies that have challenged this mode.
Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score.
Chronic obstructive pulmonary disease (COPD) is greatly underdiagnosed worldwide and more efficient methods of case-finding are required. We developed and externally validated a risk score to identify undiagnosed COPD using primary care records.We conducted a retrospective cohort analysis of a pragmatic cluster randomised controlled case-finding trial in the West Midlands, UK. Participants aged 40-79 years with no prior diagnosis of COPD received a postal or opportunistic screening questionnaire. Those reporting chronic respiratory symptoms were assessed with spirometry. COPD was defined as presence of relevant symptoms with a post-bronchodilator forced expiratory volume in 1 s/forced vital capacity ratio below the lower limit of normal. A risk score was developed using logistic regression with variables available from electronic health records for 2398 participants who returned a postal questionnaire. This was externally validated among 1097 participants who returned an opportunistic questionnaire to derive the c-statistic, and the sensitivity and specificity of cut-points.A risk score containing age, smoking status, dyspnoea, prescriptions of salbutamol and prescriptions of antibiotics discriminated between patients with and without undiagnosed COPD (c-statistic 0.74, 95% CI 0.68-0.80). A cut-point of ≥7.5% predicted risk had a sensitivity of 68.8% (95% CI 57.3-78.9%) and a specificity of 68.8% (95% CI 65.8.1-71.6%).A novel risk score using routine data from primary care electronic health records can identify patients at high risk for undiagnosed symptomatic COPD. This score could be integrated with clinical information systems to help primary care clinicians target patients for case-finding.
Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension.
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Cigarette smoke (CS) drives disease development and progression. The epithelial barrier is damaged by CS with increased monolayer permeability. However, the molecular changes that cause this barrier disruption and the interaction between adhesion proteins and the cytoskeleton are not well defined. We hypothesized that CS alters monolayer integrity by increasing cell contractility and decreasing cell adhesion in epithelia.
Anti-TNFα Therapy in Inflammatory Lung Diseases bn.
Increased levels of tumor necrosis factor (TNF) α have been linked to a number of pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), sarcoidosis, and interstitial pulmonary fibrosis (IPF). TNFα plays multiple roles in disease pathology by inducing an accumulation of inflammatory cells, stimulating the generation of inflammatory mediators, and causing oxidative and nitrosative stress, airway hyperresponsiveness and tissue remodeling. TNF-targeting biologics, therefore, present a potentially highly efficacious treatment option. This review summarizes current knowledge on the role of TNFα in pulmonary disease pathologies, with a focus on the therapeutic potential of TNFα-targeting agents in treating inflammatory lung diseases.
Changes in biophysical membrane properties induced by the Budesonide/Hydroxy-β-cyclodextrin complex.
Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a biocompatible cyclodextrin known to interact with cholesterol, is used as a drug-solubilizing agent in pharmaceutical formulations. Budesonide administered as an inclusion complex within HPβCD (BUD:HPβCD) required a quarter of the nominal dose of the suspension formulation and significantly reduced neutrophil induced inflammation in a COPD mouse model exceeding the effect of each molecule administered individually. This suggests the role of lipid domains enriched in cholesterol for inflammatory signaling activation. In this context, we investigated the effect of BUD:HPβCD on the biophysical properties of membrane lipids. On cellular models (A549, lung epithelial cells), BUD:HPβCD extracted cholesterol similarly to HPβCD. On large unilamellar vesicles (LUVs), by using the fluorescent probes diphenylhexatriene (DPH) and calcein, we demonstrated an increase in membrane fluidity and permeability induced by BUD:HPβCD in vesicles containing cholesterol. On giant unilamellar vesicles (GUVs) and lipid monolayers, BUD:HPβCD induced the disruption of cholesterol-enriched raft-like liquid ordered domains as well as changes in lipid packing and lipid desorption from the cholesterol monolayers, respectively. Except for membrane fluidity, all these effects were enhanced when HPβCD was complexed with budesonide as compared with HPβCD. Since cholesterol-enriched domains have been linked to membrane signaling including pathways involved in inflammation processes, we hypothesized the effects of BUD:HPβCD could be partly mediated by changes in the biophysical properties of cholesterol-enriched domains.
Two components of the new ESPEN diagnostic criteria for malnutrition are independent predictors of lung function in hospitalized patients with chronic obstructive pulmonary disease (COPD).
Low fat free mass index (FFMI) is a component of the ESPEN diagnosis criteria of malnutrition, that only when accompanied with weight loss is considered to be a determinant of malnutrition. Our aims were to assess the prevalence of malnutrition in patients with chronic obstructive pulmonary disease (COPD) applying the ESPEN criteria, and to examine the ability of different components of the criteria to predict COPD severity, length of stay (LOS), hospital readmissions within 30 days and mortality.
Health Effects of Airline Cabin Environments in Simulated 8-Hour Flights.
Commercial air travel is usually without health incidents. However, there is a view that cabin environments may be detrimental to health, especially flights of 8 h or more. Concerns have been raised about deep vein thrombosis, upper respiratory tract infections, altitude sickness, and toxins from the engines.


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29 June 2017: You will wish to provide strength to the path of a better future. This will create some difficult moments in front of you. But you will use your mental and physical abilities and get rid of these issues. There will be progress in investment and foreign matters. But this day will not be a great one with respect to your health and fitness matters. Have an energized suitable Sri Sri Yantra to soar over obstacles and boost your prospects. Guaranteed Results and Solutions.
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T-Mobile's Nexus devices ship without a carrier logo and have a single, uninstallable app preloaded by MrSpontaneous in Android
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Skin condition that leads to swelling on contact (xpost r/health) by acusticthoughts in WTF
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About a month ago, my Galaxy S4 caught on fire. Samsung told me that they would replace it. They have ignored me completely since then. by TweektheGeek in Android
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I returned a lost wallet last night and the owner accused me of stealing it! What's your worst "No good deed goes unpunished" story, reddit? by JoelQ in AskReddit
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Humble Bundle version of Plants Vs Zombies will not receiving new update This is why we need promo codes in the Play Store, Google! by CA719 in Android
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Inside a $34 Android 4.4 smartphone by johnmountain in Android
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About a month ago, my Galaxy S4 caught on fire. Samsung told me that they would replace it. They have ignored me completely since then. by TweektheGeek in Android
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Today was my first day without any withdrawal symptoms from heroin. Reddit, what was your proudest moment? by IM_HOMELESS_BITCH in AskReddit
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LlabTooFeR suggests that HTC One Google Edition is coming. by Hunt3rj2 in Android
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PSA from the first lady (i.imgur.com)
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Frozen food sucks. I started EVOL Foods to change all that. I am Phil Anson, AMA by in IAmA
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[Germany] Where is it... oh, THERE'S MY EXIT! (youtube.com)
Google To Terminate Tap & Pay Support On All Non-KitKat Devices From Next Month by in Android
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PSA for Lollipop: Long pressing the app icon in Recents will take you to "App info" ONLY if you have Developer options enabledLollipop (self.Android)
Whatsapp finally gets Material Design by rogeriorp in Android
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Just a heads up, MKBHD will be doing an AMA tomorrow at 10AM EST by Badluck90 in Android
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Whatsapp finally gets Material Design by rogeriorp in Android
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Lewis Hamilton forgets he no longer drives for McLaren by dumdrums in videos
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iPhone user here, I come in peace! by StacyJaxx in Android
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T-Mobile Says Android 4.4.3 is Coming to the Nexus 5 Today by bloobloo2 in Android
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This is never happening by in pics
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How many attempts? by emanuelkarlsten in pics
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Anon attends a security lecture. by in 4chan
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Satellite Beach
$20 – Dolphin & Manatee Sightseeing Cruise for 2, 55% Off
DolFun Tours
Amy Thompson
Deal Expert
The Deal
Get up-close views of dolphins, manatees and ospreys on an Indian River cruise for two that saves nearly 60%.
Why We Love It
- Pass by Merritt Island's million-dollar homes
- Cruises are BYOB; bring a cooler for the ride
- "Relaxing and enjoyable" with "lots of dolphins to see" (Travelzoo members)
What's Included
- For $15, get a 90-minute narrated sightseeing tour for one (reg. $24)
- For $20, get the tour for two (reg. $48)
- Tours depart daily at 10 a.m. and 12 p.m.
Valid during merchant's operating hours. Tours depart daily at 10 a.m. and 12 p.m. Reservations required; subject to availability. Call to make a reservation; reference voucher. Upon arrival, present printed voucher or display in Travelzoo mobile app. Tax, if applicable, and gratuity are not included. Limit one voucher purchase per person; may buy additional as gifts. If limit is exceeded, voucher subject to forfeiture. Not valid on holidays or holiday weekends (call merchant for specific date restrictions).
Subject to weather conditions. Seeing wildlife is not guaranteed. Valid for one or two people, depending on option purchased. Not valid on products. Cannot combine with other offers. Must use in one visit.
58% off
When You Can Go
Through Aug. 31, 2017
Have a Question? Contact Travelzoo.
Customer Service available 24 hours
85% Positive
(13 Member Reviews)
(13 Member Reviews)
Enjoyed Most
we was dolphins and guide was very informative
Donna May 01, 2017 ON, Canada
Enjoyed Most
Yes we saw some dolphins.
Other Comments
We never went out of the cove. Just went back and forth in a small area. Not enough information about the area. Naration was poor.
Valerie Mar 14, 2017 FL, United States
Enjoyed Most
We saw lots of dolphins, and learned so much about the area and the history. Well worth the price of admission, even if it was full price.
Stephen Sep 04, 2016 FL, United States
Enjoyed Most
At the very end, we finally saw a small group of 3 dolphins that were feeding/chasing fish into the shallow water between docks. Fish were jumping everywhere, pelicans were in on the action. Our skipper was very knowledgeable about the dolphins, manatee, birds and history of the area we were in.
Keturah Aug 30, 2016 FL, United States
Enjoyed Most
The tour was great, the skipper was friendly and knowledgeable!
leanne Aug 02, 2016 FL, United States


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Monthly Archives: April 2015
A Bad Place
While most of us, if not all of us, can remember times where life just wasn't fair to us, I doubt too many of us can say we were in a situation like Joseph's. He was separated from his family, … Continue reading
Declaration of Dependence
Psalm 119:89-94a Each year our nation celebrates July 4th as our national birthday. It is day we commemorate the signing of the Declaration of Independence. As a group of English colonies, we determined King George III had crossed a line … Continue reading
The Desert
There is a simple verse in Acts chapter 8 that I think we often ignore. At least we don't talk about it when we discuss the concept when we are talking about successful ministry. Now an angel of the Lord … Continue reading
Eight Things We Can Pray For That God Always Grants
Psalm 119:33-40 A few days ago I posted some things I noticed about Psalm 119:57-64 which describe some indicators of a mature believer. Continuing my study of the longest chapter in the Bible, I also discovered some verses where the … Continue reading
Eight Marks of a Mature Believer From Psalm 119
Nearly a year ago, I began studying Psalm 119. Yeah, that one. The longest chapter in the Bible and for many of us, quite intimidating merely because of its' length. If you can't tackle all 176 verses, where do you … Continue reading


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easy movers for furniture DM270
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All supplier products
All supplier products
Model DM270
Capacity 270kg
Lowered Height 140mm
Raised Height 250mm
Handle Height 880mm
Castor Size (Dia.) 50mm
Overall Size 840x558x880mm
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Sold Out
Order before 2pm NZT for same day dispatch- We Ship worldwide
By Quay Eyewear
Silver frame with Silver mirror Lens
- Stainless Steel Hinges
- Polycarbonate Lens
- 100% UV protection
Cat 3. Lens
As seen on Kourtney Kardashian & Kylie Jenner!
|14cm - 5.51"
|6cm - 2.36"
|Nose Gap:
|1.5cm - 0.59"
Care instructions :
Don't just throw these in the bottom of your bag.
Don't leave these in a hot car; sunglasses in the heat for too long will melt.
Salt water and other chemicals don't mix, so please don't test the theory.
Don't wear them on top of your head as it weakens the joints and misshapes the frame.
Don't use clothing or coarse materials to clean the lenses, use microfiber material or hot water and a tissue to clean the lens.