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Overall room rating
Superior Double Room
Guest accommodation
Guest accommodation
from 700 THB – Hotel
from 890 THB – Hotel
from 765 THB – Hotel
from 600 THB – Hotel
0.02 km
74/29 Soi Banzhan Nanai Road 83150, Patong Beach
0.02 km
74/24 Soi Banzaan, Nanai Rd., Kathu, Phuket 83150, Patong Beach
0.03 km
Soi Banzaan 74/38 83150, Patong Beach
0.03 km
74/33 Soi Banzaan Market, Patong Sub-district, Kathu, Phuket 81350, Patong Beach
* Wszystkie odległości są mierzone w linie prostej, od Twojego punktu do celu.
All bookings are confirmed instantly. No waiting, no email exchanges, no confusion.
A 15-minute walk from Patong Beach and a 10-minute walk to the nightlife at Soi Bangla, Sabaidee Patong Guesthouse offers basic Thai-style rooms with free WiFi. Car and motorbike rentals are available at the 24-hour front desk.
Spacious and air-conditioned, rooms all come with a flat-screen cable TV, minibar and personal safe. Some rooms have a sofa. En suite bathrooms have hot shower facilities.
Sabaidee Patong Guesthouse is a 15-minute drive from Kata or Karon Beach. It is a 20-minute drive from Kamala Beach and an hour's drive from Phuket International Airport. Jungceylon Shopping Center is a 3-minute walk away. Airport transfers are available at extra charge.
The hotel's restaurant serves Turkish, Mediterranean and Thai cuisines. It also has a bar and caters for room service.
Guests can arrange day trips at the tour desk, or request for laundry services. Free on-site parking is available.
Rooms: 20
Please note that in case of early departure, the hotel reserves the right to charge the total amount of the reservation.
Shower, Toilet, Bathroom
Air Conditioning, Desk, Wardrobe/Closet, Safety Deposit Box, Tile/Marble floor
Fax, Cable Channels, TV
Basic Thai-style room comes with air conditioning and a cable TV. Private bathrooms have shower facilities.
Bathroom, Shower, Toilet
Wardrobe/Closet, Safety Deposit Box, Desk, Air Conditioning, Tile/Marble floor
TV, Fax, Cable Channels
Large Thai-style room comes with air conditioning, safe and cable TV. Private bathrooms have shower facilities.
Toilet, Shower, Bathroom
Safety Deposit Box, Air Conditioning, Tile/Marble floor, Wardrobe/Closet, Sofa, Desk
Cable Channels, Fax, TV
Wake-up service
Large Thai-style room comes with air conditioning, a sofa and cable TV. Private bathrooms have shower facilities.
Shower, Toilet, Bathroom
Sofa, Wardrobe/Closet, Desk, Air Conditioning, Tile/Marble floor, Safety Deposit Box
TV, Cable Channels
This spacious Thai design room features air-conditioning, a balcony, a minibar. It has a sofa, a cable TV and a safety deposit box. Private bathrooms have shower facilities.
This unit can accommodate up to 4 persons with an extra bed.
Bathroom, Hairdryer, Shower, Toilet paper, Toilet
Air Conditioning, Wardrobe/Closet, Desk, Tile/Marble floor, Safety Deposit Box
Cable Channels, Flat-screen TV
Wake-up service, Towels, Linen
This twin room has a balcony, air conditioning and tile/marble floor.
After booking, all of the hotel's details, including telephone and email address, are provided in the online booking confirmation, confirmation email.
Snack bar, Bottle of water, Breakfast options, Restaurant (à la carte), On-site coffee house, Restaurant, Bar,
Meeting/banquet facilities, Fax/photocopying,
ATM/cash machine on site, Safety deposit box, Tickets to attractions or shows, Private check-in/check-out, 24-hour front desk, Concierge service, Tour desk, Express check-in/check-out, Currency exchange, Luggage storage,
Garden, Shared lounge/TV area,
Designated smoking area, Non-smoking rooms, Family rooms, Air conditioning, Heating,
Airport shuttle, Bicycle rental (additional charge), Airport pick up, Airport drop off, Airport shuttle (additional charge), Car hire, Shuttle service, Shuttle service (additional charge), Street parking,
Daily maid service, Laundry, Ironing service,
Mini-market on site, Shops (on site), Gift shop,
Pool/beach towels,
Free WiFi! WiFi is available in all areas and is free of charge.
Free parking! Free public parking is possible at a location nearby (reservation is not needed).
From 14:00 hours
From 11:00 Until 12:00 hours
All children are welcome.
One child under 4 years stays free of charge when using existing beds.
Extra beds are not available.
There is no capacity for cots in the room.
Pets are not allowed.
Reviews in language: PL
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text:
First ever disaster management cell in the State also known as 'Emergency Operation Centre' (EOC) was inaugurated at Deputy Commissioner's office complex, Dimapur, on June 23. ADC Dimapur, Sedevikho Khro at the inaugural function said newly established centre was equipped with latest state of the art equipments in dealing natural disaster like earthquake or related to any disaster. He also said that though the district does not face the danger of flood like other states yet, public are prone to natural disaster like earthquake and the main concern for the district was to come up with proper planning. He further said if high magnitude earthquake occurred in Nagaland, Dimapur would have serious impact and therefore needed preparation in dealing with the aftermath of its occurrence.ADC was optimistic that with the newly inaugurated centre, Dimapur Disaster Management Cell will effectively deal in the event of any disaster in the district. EOC includes departments like PWD, Power, Medical, Supply, Vety. and other allied departments. The cell would be headed by the Deputy Commissioner, Dimapur as incident commander.
Inspired by two students' years ago, who had difficulties in learning, I realized that there is a greater field for me to harvest and therein lies a responsibility to teach such st

subset: commoncrawl


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The ICC Twenty20 World Cup Cricket Match of India Vs Pakistan which is scheduled on March 19 to play at Dharamsala earlier but, due to security concerns, the play of match changed to "Eden Gardens" Kolkata, India. It was great loss for Dharamsala and a benefit for Kolkata audience to watch the match. After, the official meet of BCCI it informed that Kolkata has the preferrable place when compared with other venues like Bengaluru, Mohali.
The Pakistan Cricket Board (PCB) on Tuesday, Midnight told that the match should be played as per the schedule but, India BCCI clearly said that the match will be played at Kolkata due to security concern. Before it combat with India, Pakistan need to play 2 warm-up matche with two other teams at Kolkata after playing the match it would play aganist India.
The BCCI said that, for security point of View kolkata will be the best place and broadcasting of match easier, instead of spending expensive cost in playing the match at other regions. The West Bengal Government which is led by Mamata Banerjee shown much interest for the proposal of Match shifing from Dharamsala.
According to ICC Rule and Regulations, The Pakistan team should shift their camp to kolkata to play two warm-up matches aganist SriLanka on March 14, March 16 2016 with Group A qualifier. The Match After playing March 16 they need to shift their camp from Kolkata to Dharamasala. so, its better to play the Dharamsala Match on 17 March, can be played at Kolkata.
After playing the warm-up Match, their will be a match aganist India on March 19, they need to play their next match with New zealand on March 22. The Himachal Pradesh Chief Minister told we will provide a safest security but, the Pakistan Cricket Board Governer Shaharyar Khan was opposing the statement of Indian BCCI.


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The Church
Tried by Fire
The Story of Christianity's First Thousand YearsAuthor: William J. BennettNarrator: Wayne CampbellRuntime: 15.7 Hrs. - UnabridgedFull of larger-than-life characters, stunning acts of bravery, and heart-rending sacrifice, Tried by Fire narrates the rise and expansion of Christianity from an obscure regional sect to the established faith of the world's greatest empire with influence extending from India to Ireland, Scandinavia to Ethiopia, and all points in between. William J. Bennett explores the riveting lives of saints and sinners, paupers and kings, merchants and monks who together—and against all odds—changed the world forever. To tell their story, Bennett follows them through the controversies and trials of their time. Challenged by official persecution, heresy, and schism, they held steadfast to the truth of Christ. Strengthened by poets, preachers, and theologians, they advanced in devotion and love. In this moving and accessible narrative, Tried by Fire speaks across centuries to offer insight into the people and events that shaped the faith that continues to shape our lives today.Learn More
Wild at Heart
Discovering the Secret of a Man's SoulAuthor: John EldredgeNarrator: John EldredgeRuntime: 3.5 Hrs. - AbridgedGod designed men to be dangerous, says John Eldredge. Simply look at the dreams and desires written in the heart of every boy: To be a hero, to be a warrior, to live a life of adventure and risk. Sadly, most men abandon those dreams and desires-aided by a Christianity that feels like nothing more than pressure to be a "nice guy." It is no wonder that many men avoid church, and those who go are often passive and bored to death. In this provocative book, Eldredge gives women a look inside the true heart of a man and gives men permission to be what God designed them to be-dangerous, passionate, alive, and free.Learn More
The Azusa Street Mission and RevivalAuthor: Cecil Robeck, Jr.Narrator: Barry ScottRuntime: 13.33 Hrs. - UnabridgedIn Azusa Street Mission and Revival, Cecil M. Robeck, Jr. brings to bear expertise from decades of focused study in church history to reveal the captivating story of the Apostolic Faith Mission in Los Angeles, which became known as the Azusa Street Mission. From humble beginnings with few resources, this small uniquely diverse and inclusive congregation led by William J. Seymour ignited a fire that quickly grew into a blaze and spread across the world giving rise to the global Pentecostal movement. Sifting through newspaper reports and other written accounts of the time as well as the mission's own publications, and through personal interaction with some of those blessed to stand very near to the fire that began at the mission, Cecil M. Robeck, Jr. relates not only the historical significance of the revival but also captures the movement of the Holy Spirit that changed the face of modern Christianity.Learn More
The Hole in Our GospelAuthor: Richard StearnsNarrator: Tommy CreswellRuntime: 10.5 Hrs. - UnabridgedThis is a story of how a corporate CEO faced his own struggle to obey God whatever the cost, and his passionate call for Christians to change the world by actively living out their faith. Using his own journey as an example, Stearns explores the hole that exists in our understanding of the Gospel.Learn More
The Dawn of Christianity
How God Used Simple Fishermen, Soldiers, and Prostitutes to Transform the WorldAuthor: Robert J. HutchinsonNarrator: Bill RussellRuntime: 8.5 Hrs. - UnabridgedDrawing upon the most recent discoveries and scholarship in archaeology and the first-century Near East, The Dawn of Christianity reveals how a beleaguered group of followers of a crucified rabbi became the founders of a world-changing faith. How did Christianity truly come to be? Where did this worldwide faith come from? The Dawn of Christianity tells the story of how the first followers of Jesus survived the terror and despair of witnessing the one they knew to be the messiah—God's agent for the salvation of the world—suddenly arrested, tried, and executed. Soon after Jesus' death, his relatives and closest followers began hearing reports that Jesus was alive again—reports that even his most loyal disciples at first refused to believe. Using the most recent studies by top Christian and secular scholars, Robert Hutchinson, known for his popular books on Christianity and Biblical Studies, reconstructs all of the known accounts of these early resurrection appearances and follows the witnesses to the resurrection as they experience brutal persecution at the hands of zealots such as Saul of Tarsus and then become committed evangelists to the major population centers in Antioch, Damascus, Rome, and Athens—and ultimately across the world. A riveting thriller of the most improbable history-changing movement imaginable, The Dawn of Christianity brings to life the compelling story of the birth of Christianity.Learn More
The Catalyst Leader
8 Essentials For Becoming a Change MakerAuthor: Brad LomenickNarrator: Heath McClureRuntime: 5.5 Hrs. - UnabridgedThe Catalyst Leader provides practical help for all leaders at any stage of their leadership journey, ultimately defining what it means to be a Catalyst in this generation, and inspiring us all to be true change makers wherever we lead. The question isn't how do we lead now; it's how do we lead well. This is the new generation of leaders' handbook for influence. Practical. Inspiring. Timely. Defining. Get ready for your own leadership to be taken to a new level.Learn More


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Explore Pain Quotes, Quotes Quotes and more!
"Are you alive or just existing" quote
Heathers- Every time I watch this movie, I have to rethink my life
☽ ☼ ƈʜɪʟʟ ѵɪвěs ☼ ☾
Lost in memories
Do you think the universe fights for souls to be together ... I hope so.
quote, vintage and grunge image on We Heart It
♡ pinterest : brittesh18 ♡


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Recent guest reviews
There was no welcome by the desk clerk, just a process. The room seemed clean enough but everything was old, dated, worn...especially the very thin towels. The most maddening part of our stay occurred the next morning: No shampoo. We expect shampoo. Why no shampoo? We used a miserable little bar of soap and it was so old, there was no lather. We didn't eat their spartan continental breakfast. We just left.
We have stayed at this hotel several times, and ussually are happy with it. We have come to the conclusion though that during the summer months we will stay elsewhere. The ac isn't powerful enough to cool the room sufficiently. We have stayed in multiple rooms and still the same. The heat works great. Generally we are very pleased with the staff. They're polite, professional, and helpful. However, last night we stayed in room 226 and when we opened the refrigerator door it came off in my hand. When I asked the desk clerk about getting another one he said maintenance was gone. I asked if we could get one from an empty room or something and he stated they were booked upand didn't have empty rooms. Have to call BS on that one. Approximately 2/3's of the rooms appeared to be empty when I looked. No cars, curtains open, un occupied. From now on we will stay elsewhere.
Easy to find, just drive Route 66. The hotel is ok, little worn. Friendly staff, free breakfast ok, free wi-fi, free parking. The room was big enough, small flies and one cockroach (semi dead). The room was need of renovation (floor matress was broken, bathroom...). It was equipped with tv, phone, clock/radio, micro, fridge, iron and board and aircon.
Accommodations as expected...clean, excellent breakfast buffet...hot and cold cereal, plenty of coffee, juice...muffins, toast, make your own waffles, biscuits and gravyVery nice employees...helpful. We were here two nights...very quiet, room temperature satisfactory.
Staff were friendly at the check-in, room was clean and comfortable. No significant noise even though the train tracks ran fairly close back of the hotel. Breakfast in the morning was decent and well supervised. QWe were pleased with our stay.
My husband has stayed at this hotel for business for aabout a year and a half about 8 times per year. In my first review, this hotel was fine and a good price but something changed around last spring with the hot water. Due to the time of his meetings, he has to get up at 4:30am and there was never any hot water even though he ran if for over 20 minutes. When he asked about it at the desk, they said they would put him in a room closer to the hot water heater. This did not help. The front desk did not seem to care too much about the problem. So we have changed to the Best Western. $25 more per night but worth it.
For the what we paid for a room here, I thought it was reasonable. Rooms are huge and have a microwave and oversized mini fridge which is nice. Bathroom is pretty small and there were a few hairs in there. There were also some pet hairs on the blanket on the bed. Since it is set up like a motel, it is nice that you can park right outside your front door. Complimentary breakfast was good. Waffles, cereal, muffins, toast, fruit, yogurt. Our biggest issue was that when we got there, the front desk was in the middle of giving our room away to someone else, even though we had called ahead and let them know we wouldn't be there until late at night. Luckily she gave the room to us and must have figured something else out for the other guest, but if we would have gotten there a minute later we would have been without a room.
We have been on a Route 66 tour for ten days....and have stayed in 10 different motels, many of them franchise types. This was the cleanest, nicest, most friendly of the lot! Even the breakfast was nice and an attendant was cleaning the tables, food area and straightening chairs continually. We would stay there again in a heartbeat! A great value!
This aging hotel reflects life in Holbrook, a little city once known as "the town too tough for women and churches." In 1914 it was said to be the only county seat in the U.S. that didn't have a church. When the Beale Wagon Road became Route 66 in 1926, it passed through Holbrook and became a stop-over for early road travelers. Holbrook is now quite rundown and Route 66 makes little difference. The 2010 census reveals Holbrook is 24 percent Native American, meaning mostly descendents of the Navajo tribe. We picked the Magnusson Adobe Motel in advance, lured by low price and location. It's a big old motel, but we only counted nine cars in the parking lot on our departure. Management has tried to upgrade. It has been refurbished somewhat and they keep it clean, but they can't hide old age. Rooms have low wattage lighting. It is dog-friendly so we had our little Maggie along with us. I took the dog for a half mile walk down the main drag to the town center. There were closed buildings, cracked sidewalks, few pedestrians, little to get one's attention. The little Roxy movie house, still open, announced a film would be shown at 6 p.m. In the recent past, a restaurant was next door to the motel. It was closed, permanently be evidence of the tall sign. With few restaurant choices, we opted to shop at the Safeway's deli across the street. We dined in our little room. Trains shake the buildings but beds are comfortable. We enjoyed the simple breakfast monitored by the overnight clerk, a polite Native American. I felt sorry for the motel owners, the Navajo citizens and others who live in this Navajo County city. On the plus side, motel is money-saver, close to Petrified Forest National Park. Give 'em a visit if you're not too fussy. If it's hot, you might enjoy the small swimming pool.
This is a poorly kept hotel! On arrival no greeting and was not happy to discover when we went to the room that there were towels for only one of our party of 4. Also there was only 3 pillows on one of the beds. I called front desk and was told to check the rail above the toilet ( of course I wouldn't have checked first) to then be told to go collect them myself- when i asked about the missing pillow i was informed it had been stolen! So i asked if he had any spare to be told No! So i then asked if he could take one from a vacant room but they were fully booked because of a fair. The air conditioning in the room rattled and made a racket and the vent is hanging down and full of dust! The towels are as grey and old as the hotel- will be advising my tour operator on my return
Hotel highlights
- Free continental breakfast
- Free WiFi in rooms and public areas
- Free parking
- Bar/lounge
Located within a leisurely stroll of Navajo County Historical Society Museum, Magnuson Hotel Adobe Inn is within a few miles (5 km) of Northland Pioneer College. This 54-room motel welcomes guests with free breakfast and conveniences like an outdoor pool and free in-room WiFi. It's also close to Navajo County Government Complex and Hidden Cove Golf Course.
Start your day off right with a free continental breakfast offered each morning. At the end of the day, the bar/lounge is a great place to grab a drink.
The 54 rooms are air-conditioned and have an array of amenities, including microwaves, refrigerators, and free local calls. Guests can expect free WiFi and 32-inch flat-screen TVs with cable channels. Ironing boards are also included.
Property features
At Magnuson Hotel Adobe Inn, guests enjoy an outdoor pool, a fitness center, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has multilingual staff ready to assist with sightseeing, directions, and local dining recommendations. Additional amenities include a business center and coffee/tea in a common area.
Reviews from Trip Advisor
45% of guests recommend this hotelTotal of 151 reviews


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Recent releases:
- Baby Driver
- Transformers: The Last Knight (3D)
- Book of Henry, The
- Hampstead
- Dying Laughing
- Gifted
- My Cousin Rachel
- Wonder Woman (3D/2D)
- My Life as a Courgette
- Hippopotamus, The
- It Was Fifty Years Ago Today! The Beatles: Sgt. Pepper and Beyond
- Diary of a Wimpy Kid: The Long Haul
- Other Side of Hope, The/Toivon tuolla puolen
- Baywatch
- Pirates of the Caribbean: Salazar's Revenge
- Detour
- King Arthur: Legend of the Sword
- Secret Scripture, The
- Whisky Galore!
- Snatched
I Love You Phillip Morris
Stars: Jim Carrey, Ewan McGregor, Leslie Mann, Rodrigo Santoro
Director: Glenn Ficarra, John Requa
There's offbeat, there's strange, there's off-the-wall, there's barking mad, and then there's I Love You Phillip Morris. Veering wildly between comedy and tragedy, from one opposing emotion to another, the film, like a rollercoaster ride where the participants keep falling off, relates the bizarre true story of Steven Russell (Carrey with a haircut that recalls the prissier styles of Dimitar Berbatov).
Married with a daughter, Steven is a policeman and closet gay, resorting to cons and scams to aggressively pursue his alternative liferstyle, one of which eventually lands him in prison. Here he falls heavily for dewy-eyed Phillip (McGregor) who returns his affections, leading Steven to resort to elaborate ruses to a) get in the same cell, and b) free Phillip altogether.
An intricate series of forged references lands him a plum job as finance director to a large firm, but he's unable to resist stealing to maintain his and Phillip's pampered existence in a mansion-style home. Rumbled, and spurned by a deceived Phillip, Steven flees but is soon back in jail, where a final act in the jaw-dropping charade is soon under way.
Carrey is very odd casting as Steven, but presumably the producers wanted to steer the film as often as possible into the realm of comedy. All in all, the star does pretty well with a nigh-on impossible character, while McGregor gives one of his better performances as the conman's inamorata.
David Quinlan
USA 2009. UK Distributor: E1 Entertainment. Colour.
97 minutes. Not widescreen. UK certificate: 15.
Guidance ratings (out of 3): Sex/nudity 2, Violence/Horror 0, Drugs 0, Swearing 2.
Review date: 16 Mar 2010


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Relevant offers
Kiwi wineries' profitability has continued to rebound after the oversupply of 2008-09 and the crushed earnings caused by an industry with too many grapes and too much debt.
The seventh annual Deloitte 2012 Vintage New Zealand Wine Benchmarking Survey released today shows most wine companies reported an increase in profits as a proportion of revenue for this year's vintage.
The industry must now deal with constrained production until at least 2016, New Zealand Winegrowers says.
NZ Winegrowers chief executive Philip Gregan said the report showed improving profitability on the back of a more balanced supply-demand situation.
A recent stocktake of Kiwi vineyards showed little increase in producing vines between now and 2016, meaning grape production was fixed apart from seasonal fluctuations, he said.
"The industry is now in the process of managing shortage."
He hoped growers, wineries and banks remembered the lessons learnt from the 2008-09 oversupply ensuring there was not another explosion of vineyards.
New Zealand wine had come through the past four years in "pretty good shape" and the trends shown in the Deloitte report were promising, he said.
The report shows increased profitability for wineries, but average returns on equity were still lower than the 12 to 20 per cent band that most investors would be comfortable with, Deloitte associate director Tim Burnside said.
Wineries with revenue between $10 million and $20m were the most profitable, taking an average profit of 17 per cent of total revenue.
Deloitte sponsoring partner Paul Munro said the sector needed to remain focused on growing export value rather than volume, and warned those looking at planting new vineyards not to upset the delicate scales of grape supply.
"Such investments need to be carefully assessed to ensure they are strongly market-led and there is no repeat of the supply-demand imbalance seen in recent years."
Dayne Sherwood, of Sherwood Estates in Waipara, said there was definitely a shortage of grapes and it had happened much more quickly than he had expected.
He hoped to grow both the winery and vineyard, which turns over between $5m and $10m, but banks were still cagey about the industry.
"We'd like to grow . . . it's not quite as easy talking to your bank as it was four to five years ago," he said.
The high exchange rate was still squeezing export margins, he said, and although most Kiwi wineries had been able to increase prices overseas, it was not a complete offset.
Brent Marris, of Marisco Vineyards in Marlborough, said the burgeoning lack of grapes was foremost in his mind.
"A lot of people in the industry have had a shock from how quickly we've gone from an oversupply to a shortage."
Bulk wine sold out of Marlborough had jumped from about $2.50 a litre in 2011 to about $5.50 this year, which showed the tightening supply.
His company's revenue had grown to between $10m and $20m during the past vintage and he was confident in the industry.
He had bought a 2000-hectare station near his winery on which he planned to plant around 800ha of vines over time.
However, he needed the equivalent of 200ha of fruit "tomorrow" to satisfy demand for his wine, he said.
That meant he needed to buy an existing vineyard as well, and he was on the hunt.
Lessons learnt the hard way through the recession and oversupply had made the industry stronger and more competitive, the NBR Rich lister said.
"It's all about an industry growing up."
- The Press
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Plenty of snow and good weather for South Canterbury skifields


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April 28, 2013
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CHARLOTTESVILLE, Va.—The Virginia softball team dropped both ends of a doubleheader to Virginia Tech, 6-0 and 5-1, in front of a capacity crowd of 475 on Sunday afternoon (April 28) at The Park in Charlottesville.
The Cavaliers fell to 20-27 on the season (3-17 ACC), while the Hokies improved to 31-15 (8-8 ACC).
In the top of the third, Virginia Tech's Lauren Gaskill hit a 2-run home run to left center to open the scoring. The Hokies added a run in the fifth on a Bkaye Smith RBI single and added three more runs in the sixth.
Senior pitcher Melanie Mitchell (White Plains, Md.) allowed six runs on eight hits with five strikeouts in the loss (15-16).
Kelly Heinz (14-5) gave up five hits in six innings to earn the win.
In the second game, Virginia Tech out hit the Cavaliers, 9-4, on the way to a 5-1 win.
With VT leading 2-0 in the fourth, the Cavaliers cut the lead to one on a RBI single by junior Karli Johnson (Lovettsville, Va.) that scored sophomore Heidi Velk (Murietta, Calif.).
The Hokies extended the lead to 4-1 in the fifth on a home run by Kat Banks and a RBI double by Bailey Liddle. Gaskill hit her second home run of the day in the sixth to push the lead to 5-1.
Freshman pitcher Aimee Chapdelaine (Pembroke Pines, Fla.) pitched a complete game, allowing five runs in seven innings, but took the loss (5-10).
VT's Jasmin Harrell (14-7) gave up four hits and one run in the complete game win.
The two teams conclude the series with a single game Monday (April 29). First pitch is scheduled for 7 p.m. and the game will be broadcast on ESPNU. It will be the Cavaliers' regular season finale.
UVA Athletics Information
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Cavalier Tennis Programs Joining ForcesMen's Tennis6/21/17UVA's new head tennis coaches -- Andres Pedroso for the men and Sara O'Leary for the women -- want their programs to work closely together.Catching Up With Cherie Greer BrownWomen's Lacrosse6/19/17A 1994 graduate of UVA, where she was a three-time first-team All-American, the former Cherie Greer ranks among the finest players in lacrosse history.European Trip Strengthens Team's BondsWomen's Soccer6/14/17The Virginia women's soccer team recently returned from a trip to Europe, where the Cavaliers played two games in France and one in Germany.
Jeff White
Director of News Content
A 1985 graduate of UVA, White worked at the Richmond Times-Dispatch until July 2009. He was honored six times as the state's Sportswriter of the Year.
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Softball | 04/30/2017
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Louisville scored the game's first seven runs and eventually final four runs in an 11-3,...
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|By PR Newswire
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|November 30, 2016 09:21 AM EST
LONDON, November 30, 2016 /PRNewswire/ --
DES2017 - Digital Business World Congress, the largest global event dedicated entirely to the transformation of companies and their management
Digital Enterprise Show (DES2017), the largest global meeting on digital transformation will return to Madrid (IFEMA) on 23, 24 and 25 May 2017, with the objective, once again, of turning Madrid into the Digital Enterprise World Capital. To this end, the organization have been meeting the British Tech Industry this morning in London, in the Telefónica Open Future & Wayra UK.
(Photo: http://photos.prnewswire.com/prnh/20161130/444076 )
A panel discussion with Rachel Rowe, Regional Director, UK&I and Nordics of Forrester, together with Christian Mastrodonato, Chief Technologist of Konica Minolta, Inc and Lluis Altés, Strategy director at DES2017 was held about how to apply digital transformation to maintain and increase competitiveness to become a leader.
"According to Forrester's 2016 UK Customer Experience Index report, there's still plenty of opportunity for brands to gain competitive advantage through experience-based differentiation", declared Joana Van den Brink-Quintanilha, Customer Experience Analyst of Forrester.
Testimonials of companies that attended DES2016 shared their experience at the show and discussed about the challenges and opportunities that digitalization brings to any organization. Mr Mastrodonato said that "being part of DES2016 gave us a powerful platform to spread our vision of digital businesses and to showcase our strength on digital workplace services, sensors and information automation, healthcare and business technologies".
DES2017 will be an edition marked by the organization's commitment to help identify the state of digitalization that companies have compared to the game-changers that lead the market in each industry, through what they call the "Digital Maturity Journey". And at the same time, presenting all the technological solutions that are driving the transformation. "Organizations need guidance to figure out what is on the horizon and to define the vision to disrupt, not to be disrupted." Affirmed Lluis Altés, Strategy Director DES - Digital Business World Congress.
The organization plans to bring together more than 18,000 professionals from 40 different nationalities in the second edition of DES, and is developing an exhaustive internationalization plan presenting DES-Digital Business World Congress in different capitals with the most important technological ecosystems worldwide.
DES2017 is becoming the global business conference on digital business, where to present the technological innovations that help improve the customer experience, processes and daily business operations.
You know you need the cloud, but you're hesitant to simply dump everything at Amazon since you know that not all workloads are suitable for cloud. You know that you want the kind of ease of use and scalability that you get with public cloud, but your applications are architected in a way that makes the public cloud a non-starter. You're looking at private cloud solutions based on hyperconverged infrastructure, but you're concerned with the limits inherent in those technologies.
Jun. 28, 2017 10:15 PM EDT Reads: 731
"Loom is applying artificial intelligence and machine learning into the entire log analysis process, from start to finish and at the end you will get a human touch," explained Sabo Taylor Diab, Vice President, Marketing at Loom Systems, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
Jun. 28, 2017 10:00 PM EDT Reads: 2,036
@DevOpsSummit at Cloud Expo taking place Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center, Santa Clara, CA, is co-located with the 21st International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is ...
Jun. 28, 2017 09:15 PM EDT Reads: 1,288
SYS-CON Events announced today that Datanami has been named "Media Sponsor" of SYS-CON's 21st International Cloud Expo, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Datanami is a communication channel dedicated to providing insight, analysis and up-to-the-minute information about emerging trends and solutions in Big Data. The publication sheds light on all cutting-edge technologies including networking, storage and applications, and the...
Jun. 28, 2017 08:00 PM EDT Reads: 347
After more than five years of DevOps, definitions are evolving, boundaries are expanding, 'unicorns' are no longer rare, enterprises are on board, and pundits are moving on. Can we now look at an evolution of DevOps? Should we? Is the foundation of DevOps 'done', or is there still too much left to do? What is mature, and what is still missing? What does the next 5 years of DevOps look like? In this Power Panel at DevOps Summit, moderated by DevOps Summit Conference Chair Andi Mann, panelists loo...
Jun. 28, 2017 07:45 PM EDT Reads: 1,216
SYS-CON Events announced today that EnterpriseTech has been named "Media Sponsor" of SYS-CON's 21st International Cloud Expo, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. EnterpriseTech is a professional resource for news and intelligence covering the migration of high-end technologies into the enterprise and business-IT industry, with a special focus on high-tech solutions in new product development, workload management, increased effi...
Jun. 28, 2017 07:15 PM EDT Reads: 395
For organizations that have amassed large sums of software complexity, taking a microservices approach is the first step toward DevOps and continuous improvement / development. Integrating system-level analysis with microservices makes it easier to change and add functionality to applications at any time without the increase of risk. Before you start big transformation projects or a cloud migration, make sure these changes won't take down your entire organization.
Jun. 28, 2017 05:15 PM EDT Reads: 2,121
Cloud promises the agility required by today's digital businesses. As organizations adopt cloud based infrastructures and services, their IT resources become increasingly dynamic and hybrid in nature. Managing these require modern IT operations and tools. In his session at 20th Cloud Expo, Raj Sundaram, Senior Principal Product Manager at CA Technologies, will discuss how to modernize your IT operations in order to proactively manage your hybrid cloud and IT environments. He will be sharing bes...
Jun. 28, 2017 05:00 PM EDT Reads: 749
A look across the tech landscape at the disruptive technologies that are increasing in prominence and speculate as to which will be most impactful for communications – namely, AI and Cloud Computing. In his session at 20th Cloud Expo, Curtis Peterson, VP of Operations at RingCentral, highlighted the current challenges of these transformative technologies and shared strategies for preparing your organization for these changes. This "view from the top" outlined the latest trends and developments i...
Jun. 28, 2017 04:45 PM EDT Reads: 2,021
Automation is enabling enterprises to design, deploy, and manage more complex, hybrid cloud environments. Yet the people who manage these environments must be trained in and understanding these environments better than ever before. A new era of analytics and cognitive computing is adding intelligence, but also more complexity, to these cloud environments. How smart is your cloud? How smart should it be? In this power panel at 20th Cloud Expo, moderated by Conference Chair Roger Strukhoff, paneli...
Jun. 28, 2017 04:00 PM EDT Reads: 1,222
SYS-CON Events announced today that MobiDev, a client-oriented software development company, will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. MobiDev is a software company that develops and delivers turn-key mobile apps, websites, web services, and complex software systems for startups and enterprises. Since 2009 it has grown from a small group of passionate engineers and business...
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Hardware virtualization and cloud computing allowed us to increase resource utilization and increase our flexibility to respond to business demand. Docker Containers are the next quantum leap - Are they?! Databases always represented an additional set of challenges unique to running workloads requiring a maximum of I/O, network, CPU resources combined with data locality.
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SYS-CON Events announced today that GrapeUp, the leading provider of rapid product development at the speed of business, will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Grape Up is a software company, specialized in cloud native application development and professional services related to Cloud Foundry PaaS. With five expert teams that operate in various sectors of the market acr...
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SYS-CON Events announced today that Ayehu will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on October 31 - November 2, 2017 at the Santa Clara Convention Center in Santa Clara California. Ayehu provides IT Process Automation & Orchestration solutions for IT and Security professionals to identify and resolve critical incidents and enable rapid containment, eradication, and recovery from cyber security breaches. Ayehu provides customers greater control over IT infras...
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Artificial intelligence, machine learning, neural networks. We're in the midst of a wave of excitement around AI such as hasn't been seen for a few decades. But those previous periods of inflated expectations led to troughs of disappointment. Will this time be different? Most likely. Applications of AI such as predictive analytics are already decreasing costs and improving reliability of industrial machinery. Furthermore, the funding and research going into AI now comes from a wide range of com...
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After getting excepted to the university of your dreams your gran decided to rent a house out to you and a few friends. Well living there for awhile and just getting rid of a monster of a roommate your friend/roommate Hange decides to let a good friend if hers, Levi Ackerman, move in. At first things seem great, then out of no where the tables turn and things get awkward...
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Taste and See the Goodness of the Lord
Written by Therese Johnson Borchard
Illustrated by Phyllis V. Saroff
Taste and See the Goodness of the Lord by Therese Johnson BorchardHow can any of us, but especially children, know God? Using the phrase from the Psalm as a jumping-off point -- Taste and see the goodness of the Lord -- this color-drenched book answers the question with a celebration of the senses. In poetic language, the author summons up richly evocative scenes that children are experiencing for the first time and that adults will recall with great pleasure -- cotton candy from a carnival, crickets at night, brownies fresh from the oven, the tickle of snowflakes on eyelashes. For each of the five senses, there are several scenes illustrated with lush images that immediately summon up the sensation.
About the Author
Other Formats
Book Info
Therese Johnson Borchard
More books by Therese Johnson Borchard
Paulist Press International,U.S.
Publication date
1st January 2000
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London > Hotels > Mid-Range Chain Hotel from £63 24% off
Imperial Road, SW6 | 8 minutes from Emile's
Located at Imperial Wharf, the Double Tree by Hilton Hotel London - Chelsea is nearby to the chic Kings Road and Chelsea Harbour. Famous London attractions ... More
London > Hotels > Luxury Chain Hotel from £144 36% off
Chelsea Harbour, SW10 | 10 minutes from Emile's
Now owned by Millennium Hotels and Resorts, The Chelsea Harbour is a 5 star luxury all-suite hotel ideally located for both business and leisure travellers. It ... More
London > Hotels > Mid-Range Chain Hotel from £66 39% off
Stamford Bridge, SW6 | 13 minutes from Emile's
The Millennium & Copthorne Hotels at Chelsea FC benefit from a thoroughly modern design with all the comforts and conveniences that brings. There's broadband in every ... More
Alternative French restaurants nearest Emile's
London > Restaurants > French restaurants
45-47 Parsons Green Lane, SW6 | 9 minutes from Emile's
Cote adds to the eating out options in Parsons Green, giving West London locals a chance to enjoy all day dining, bistrot style. Offering French bistro ... More
London > Restaurants > French restaurants
79 Sherwood Court, Chatfield Road, SW11 | 11 minutes from Emile's
French Cuisine... More
London > Restaurants > French restaurants
228 York Road, SW11 | 12 minutes from Emile's
Little Bay is pure theatre, like stepping into the Moulin Rouge in its heyday or finding yourself in a 1920s speakeasy, candlelit and avant-garde. You half ... More
Dining near Emile's
London > Restaurants > Indian/South Asian restaurants
144 Wandsworth Bridge Road, SW6 | Same location as Emile's
Indian/South Asian Cuisine... More
London > Restaurants > Brasseries
130 Wandsworth Bridge Road, SW6 | 1 minute from Emile's
Brasseries... More
London > Restaurants > Modern European restaurants
182-184 Wandsworth Bridge Road, SW6 | 1 minute from Emile's
Modern European Cuisine... More
Events near Emile's
Entertainment near Emile's
London > Entertainment > Jazz Clubs
90 Lots Road, SW10 | 13 minutes from Emile's
Lots Road may be associated with auctions and designer showrooms, but it is also home to the 606 Club. This club will appeal to people looking ... More
London > Entertainment > Live Music
42-44 Battersea High Street, SW11 | 15 minutes from Emile's
Hot Club Gypsy Swing is a bizarrely niche musical genre for a wine bar in Battersea. Live acts vary depending on which night of the week ... More
London > Entertainment > Theatres
118 Finborough Road, Fulham, London SW10 | 19 minutes from Emile's
The Finborough Theatre in Earls Court punches well above its weight, presenting award-winning plays and works by new writers in a small theatre above a pub. ... More
Sights and Attractions near Emile's
London > Attractions > Attractions for Kids
735 Fulham Road, SW6 | 11 minutes from Emile's
All Fulham mums know and love the Pottery Cafe - it's practically a rite of passage for new mums to take their babies here to get ... More
London > Attractions > Other Attractions
Unit 1 & 2 Yelverton Road, Battersea, SW11 | 13 minutes from Emile's
An independent brewery on an unlikely housing estate in Battersea, Sambrook's was set up in August 2008 to give London drinkers some local brews to choose ... More
London > Attractions > Other Attractions
Fulham Road, Fulham, London SW10 | 15 minutes from Emile's
Opened in the mid-19th century Brompton Cemetary was set up as one of the 'Magnificent Seven' series of cemeteries, which included Highgate Cemetery, established to cope ... More
Shopping near Emile's
London > Shopping > Motoring
611 King's Road, SW6 | 9 minutes from Emile's
When Captain Frederick James Warr founded Europe's oldest Harley-Davidson dealership on the Kings Road in 1924, the flagship model was the 'Silent Grey Fellow' which retailed ... More
London > Shopping > House and Garden
421 Design Centre East, Chelsea Harbour, SW10 | 10 minutes from Emile's
Showroom for the company set up by Helen Cormack in 2006 specialising in fabrics and wallpapers from England, ... More
London > Shopping > Hair and Grooming
612 Fulham Road, SW6 | 12 minutes from Emile's
This excellent hair and beauty clinic on the Fulham Road offers the full range of beauty treatments. Gina Conway is an American born hair and beauty ... More
Education near Emile's
London > Education > Universities and Colleges
1 Hester Road, Battersea, London SW11 | 23 minutes from Emile's
The £21 million Dyson Building makes up the largest part of the purpose-built Battersea campus of the prestigious Royal College of Art. Located at 1 Hester ... More
London > Education > Arts and Drama
155 Talgarth Road, Hammersmith, London W14 | 32 minutes from Emile's
LAMDA is among the most famous and prestigious acting schools in the world. It is very hard to be selected for a course here, but almost ... More
London > Education > Evening Classes
165 Queen's Gate, South Kensington, South Kensington, London SW7 | 36 minutes from Emile's
There are plenty of initiatives trying to get kids involved in science, but the Dana Centre, an extension of the Science Museum, is the first one ... More
Leisure near Emile's
London > Leisure > Parks and Gardens
New Kings Road, SW6 | 5 minutes from Emile's
Eel Brook Common is a pleasant, grass mini-park in the London Borough of Hammersmith and Fulham between Parsons Green and Fulham Broadway tube stations. It has ... More
London > Leisure >
19 Michael Road, SW6 | 8 minutes from Emile's
Climbing meets theme park at Clip n Climb Chelsea where there are 22 separate challenges from the Jungle Gym to the Skyscraper. Take the Speed Climbing ... More
Pubs near Emile's
London > Restaurants > Gastropub
135-137 Stephendale Road, SW6 | 4 minutes from Emile's
In an unlovely part of West London that has few transport links (somewhat improved by the opening of the long-awaited Imperial Wharf station) is a funny ... More
London > Nightlife > Pubs
1-3 Parson's Green, SW6 | 7 minutes from Emile's
It may get bad press for being the "Sloaney Pony" but there's no doubting that The White Horse is one of London's best pubs. Located on ... More
London > Nightlife > Pubs
22 Waterford Road, SW6 | 9 minutes from Emile's
Award-winning chef Claude Compton, together with Jim Morris and George McCabe - the team behind critically acclaimed neighbourhood restaurant Claude's Kitchen - have created their perfect ... More
Nightlife near Emile's
London > Nightlife > Bars
461 North End Road, SW6 | 13 minutes from Emile's
Hidden below Hanger SW6, Below The Cut is a drinking den for meat lovers with liquor and cocktails served alongside bar snacks that champion a forgotten ... More
London > Nightlife > Wine Bars
18-22 Vanston Place, SW6 | 13 minutes from Emile's
The first and original Vagabond , this Fulham wine bar was set up in September 2010 in a former clothes ... More
Meeting venue hire near Emile's
London > Business > Venue Hire
Stamford Bridge Ground Fulham Road, Fulham, London SW6 | 13 minutes from Emile's
What a difference a game makes... at the end of 1993, a couple of surprise results lifted the Blues out of mid-table and into the Champions ... More
London > Business > Venue Hire
Warwick Road, Earls Court, London SW5 | 24 minutes from Emile's
... More
London > Business > Venue Hire
66 Royal Hospital Road, Chelsea, Chelsea, London SW3 | 29 minutes from Emile's
The largest fruiting olive tree in Britain and the world's northern-most outdoor grapefruit tree call the historic Chelsea Physic Gardens home. Hidden behind towering brick walls, ... More
Also in Wandsworth Bridge Road
Our recommendations in the same street as Emile's
Alternate names and popular misspellings for Emile's
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What's On Today
Near Emile's
Theatre | Until 8th July 2017
London Theatre Workshop 6 minutes walk from Emile's
Into The Woods
Theatre | Until 24th June 2017
Chelsea Theatre 17 minutes walk from Emile's
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Nobu Shoreditch
At the heart of Nobu Hotel Shoreditch, this stunning 240-seat restaurant is the place to ...More
VQ Aldgate
Famous for staying open 24 hours VQ is a great spot, day or night, for ...More
Shikumen Aldgate
Shikumen at Dorsett City follows in the footsteps of its flagship restaurant at Dorsett Shepherds Bush, which has received Bib Gourmand from the Michelin guide inspectors....More
The Ivy Tower Bridge
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Tom Simmons
Tom Simmons, a former star of MasterChef: The Professionals, dishes up cockle popcorn, laverbread mayonnaise ...More
Rola Wala
After the success of Street Feast residencies Rola Wala serves up authentic, healthy, every day ...More
Tibits Bankside
Displaying over vegetarian 40 dishes, tibits retains its showcase centrepiece at its second London restaurant....More
The Oystermen Seafood Bar and Kitchen
The Oystermen, aka Matt Lovell and Rob Hampton, ...More
Modern brasserie in Camden Market with Lee Andrews, formerly of Chiltern Firehouse, as head chef ...More
Hampstead Beach
Seasonal | From 2nd July
Summer's coming to Hampstead with an urban beach at JW3 with golden sand, free entry, ...More
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Blog Post
Marine Engine Parts Supplier Gives Ideas For Your Sound System
Your Marine Engine Parts Analysts Show You How to Bring the Best Audio Aboard Without Going Broke
Stainless Marine your marine engine parts specialists would like to share with you these topics we thought would be of interest to you this week regarding how to boost your boat's sound system without breaking the bank.
It's the end of an idyllic day. Your marine engine parts professionals know what its like to have your engine is burbling through the no-wake zone, water's chuckling against the hull. The sunset is molten gold. It's perfection, and yet…you can't place it, but something is missing. A something to make this moment last forever. You know, like a scene from a movie. I'll tell you what's missing-a soundtrack. Your performance engine parts experts know that you've known it since seeing Lawrence of Arabia-life would be nine ways better if it had background music.
Worth Listening To
"I hear everything," says Marrero, and he's only half kidding. He comes by his expertise genetically: a family in music, and a youth misspent doing what he calls "sound reinforcement" for the B-52s.
Today I'm following him through one of his typical installations, aboard a 158′ Italian megayacht. It's getting a complete audio refit, and the interior has been almost completely gutted.
To make his point, Marrero puts me in front of a $2,500 pair of Revel speakers he considers to be good-and oh, my! Your high performance marine parts specialists understand that they deliver such a deep sound that it feels like you could walk into it and stroll around. The two high-end speakers Marrero favors are the California-built Revels and B&W speakers from England.
"Good audio produces more detail and clarity," Marrero explains, "for a full presentation." These aren't the empty modifiers used by wine critics. You don't have to be Niles Crane to grasp the meaning of clarity and detail. Marrero means them quite literally.
If all that sounds intimidating, relax. You'll hear the difference just as easily as you can smell burnt toast. When comparing, it's that obvious. What is better, according to Marrero, is that audio technology is constantly improving.
Real World, Real Ears
The $200 Solution Custom Sight and Sound's John "The Ear" Marrero recommends the handy, portable Sony Sport Series CFD-980. Your boat engine parts analysts know that it's a rugged, splash-resistant CD/cassette/ radio with 10-second shock protection for its CD player, which provides a signal for 10 seconds despite interruptions due to rough-water impacts.
Your Marine Engine Parts Experts Have All the Options for You to Choose From
You can find more information as well as get assistance on boat engine parts and on how to boost your boat's sound system at Stainless Marine.
The $500 to $700 Solution Marrero recommends the Poly-Planar AM/FM/cassette stereo ($320), ideal for a center console or sportboat, combined with either Poly-Planar Platinum Series speakers ($200 to $290 a pair) or MB Quart speakers ($300 to $400 a pair).
The $1,500 Solution A slightly bigger boat, or slightly more demanding ears, will be satisfied by selecting the $700 solution and adding the following. First, put in an automotive audio amplifier such as a Sony XM 475GSX ($400). "Most marine systems are underpowered," says Marrero.
The $4,000 Solution There's not much improvement to be made to the $1,500 solution. Your marine boat parts for sale analysts say that you can start building a serious onboard entertainment center. Add a Sharp flat-screen TV (about $1,100) and a Sony DVX-100 DVD player (about $1,200).
The $8,600 Solution Once your boat goes over 40′, you have room to do things right. Take our top end and add a 13″ Sharp LCD display for TV and DVD, plus a Furuno nav-display with a video card so your radar can do double duty as a DVD viewer. Include a six-disc CD changer such as a Sony CDX-T70MX ($250).
Speaker Hints
-To avoid interference, keep speaker wires as far from the boat's wiring and electronics as possible.
-Shielded oxygen-free wires with gold-plated connectors and silvered tips are best.
-Isolate the front of the speaker with an airtight enclosure.
-Cover speakers with acoustically transparent material.
-Speakers should be forward of the listener and at ear level. Do not put them in footwells or low to the deck.
Stick It in Your Ear
On deck, your sound system's biggest enemy is the wind. Look at our boat tests and you'll see decibels (dB) levels-a measure of sound pressure, or loudness-in the high 80s and up into the 90s-while underway.
A killer audio system might be able to put out up to 140 decibels, but the quality of its sound, particularly the higher frequencies, will be lost to the breezes.
The plugs bring noise levels down by about 30 dB-A and allow you to listen to music at normal levels so there is no distortion. The sound quality is that of good "ear bud" speakers in a quiet room.
On long trips in open boats, I have taken to wearing generic foam earplugs to cut down on hearing loss and exhaustion from wind noise.
So don't forget these helpful tips on how to make the right choice when boosting your boat's sound system. 1) You don't need to stress out about the price; 2) do your homework on you speakers; and 3) give those sound systems a test run.
Stainless Marine always has more information on marine engine parts, boat engine parts, marine boat parts, and on how to boost your boat's sound system without breaking the bank.
via Upgrading Your Boat's Sound System


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July 8th, 2016
Episode 2784 of 5042 episodes
It takes courage to 'Break Down Barriers and Welcome Change' and it takes strength to overcome differences. Kevin receives a Facebook friend request from his father. After much deliberation and concern over his father will find out he's gay, he finally sends a message saying: "Dad, accepted you." His father replies: "Son, so have I." Agency: Dentsu Jayme Syfu, The Philippines. VIEW THE SPOT
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Welcome The Vox Markets Podcast with Justin Waite A new episode is released daily, giving you interviews with CEO's, market commentators and the stock of the day as suggested by listeners to the podcast.


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Research-article Article | Open AccessAvailable online freely| Peer Reviewed
Single-nucleotide polymorphisms (SNPs) in genes involved in immune responses and in the pharmacokinetics/pharmacodynamics of immunosuppressive drugs influence transplant outcomes of patients receiving the same immunosuppressive therapy.
The aim of our preliminary study was to determine the SNPs profiles of ABCB1/MDR-1, UGT1A9, IMPDH2, IL-10 and TNF-? genes associated with acute rejection (AR) events in renal allograft recipients. DNA was extracted from whole blood samples of 220 individuals in 3 experimental groups; Case: 41 kidney transplant patients with AR event(s), Control I: 109 kidney transplant patients without AR event, Control II: 70 healthy blood donors. Acute rejection defined as rapid, unexplained rise in serum creatinine was biopsy-proven. 19 SNPs were analyzed by Sanger Sequencing. Analysis of allele and genotype frequencies and gene-disease association tests were performed. Allele frequencies of healthy persons are in line with ones reported from Europe indicating that the studied population is representative. Statistically significant differences only by the comparison of kidney transplant patients with AR event(s) and healthy individuals are found for rs2032582 and rs1045642 SNPs of ABCB1/MDR1, the latter is also not in Hardy-Weinberg equilibrium in our population. Patients with specific alleles for these SPNs are more prone to have acute rejection events.
Certain allele variants of ABCB1/MDR1 by modifying the effectiveness of the drugs may compromise the success of the immunosuppressive therapy and put patients at higher risk to reject the new organ. Therefore screening for these polymorphisms before transplantation would help clinicians to more accurately personalize medications.
Despite the recent advances in immunosuppressive therapies, acute rejection episodes (ARE) following organ transplantation may happen even in the presence of the maximal antirejection treatment. Whenever acute rejection is confirmed, the possibility of inadequate immunosuppression, whether due to insufficient dosing or noncompliance, must be addressed. The failure to recognize this contributing factor increases the risk of continued AREs and poor long-term immunosuppression may eventually lead to graft failure.
Acute renal rejection is a sudden decline in the function of the transplanted kidney that gives rise to the creatinine levels. Rapid deterioration in the allograft function is associated with specific pathologic changes in the graft. The acute cellular rejection is characterized by infiltration of the allograft by lymphocytes and other inflammatory cells. In acute antibody-mediated rejection, the diagnosis requires morphologic evidence of acute tissue injury, circulating donor-specific alloantibodies, and immunologic proof of an antibody-mediated process (such as C4d deposition in the allograft) (1).
Transplant outcomes exhibit substantial inter-individual variability among patients receiving the same immunosuppressive medications. Genetic variability beyond that of the major histocompatibility complex (MHC) molecules (2), offers a possible explanation for the heterogeneity between individuals on the clinical course post-transplant (3).
Recent studies have shown that certain single-nucleotide polymorphisms (SNPs) in genes involved in immune responses and in the pharmacokinetics/pharmacodynamics of immunosuppressive drugs are associated with allograft rejection of several organs, as well as in kidney transplant recipients (4, 5).
Pharmacokinetics of calcineurin inhibitors (like Tacrolimus, Cyclosporine) are influenced by the multi-drug resistance 1 transmembrane pump (MDR-1) (6). Tacrolimus is transported out of the intestine, liver and kidney cells via p-glycoprotein, an efflux pump encoded by the MDR-1 gene, which is also expressed on numerous leukocytes, including T and B lymphocytes (7).
The immunosuppressive agent mycophenolic acid (MPA) is metabolized by uridine diphosphate glucuronosyltransferase 1A9 (UGT1A9). It is mainly expressed in the liver but it can be found also in the gastrointestinal tract and kidney. Several polymorphisms in this gene have been reported to enhance the glucuronidation of MPA that in turn results in a lower MPA exposure (8, 9).
Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme for de novo synthesis of guanine nucleotides, is required for cellular (for example: lymphocyte) proliferation. Inhibition of IMPDH2 by MPA constitutes part of an immunosuppressive therapy, in kidney allograft recipients too. Polymorphic variants of this gene has been associated with increased IMPDH2 activity and reduced ability of MPA to exert antiproliferative effects on lymphocytes (10).
Cytokines by affecting immune responses are also involved in allograft rejection (11). It has been revealed that tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) play a key role in the pathogenesis of transplant organ reperfusion injury and failure and are produced in the graft during kidney rejection (12).
Therefore the aim of the study was to determine complex SNPs patterns (allele and genotype frequencies), of genes involved in immune responses and in the pharmacokinetics/pharmacodynamics of immunosuppressive drugs, characteristic for kidney transplant patients with acute rejection events.
Materials And Methods
Blood samples (9 ml) were collected in EDTA-containing tubes, genomic DNA was isolated using magnetic bead-based extraction method (NorDiag Arrow instrument with Arrow Blood DNA kit) and aliquots were stored at -80°C until further analysis.
All subjects were genotyped for each SNP by polymerase chain reaction (PCR) using specific primers designed with Primer3 program (Whitehead Institute) and using AmpliTaq Gold 360 Master Mix (Applied Biosystems).
Amplification conditions were optimized and sequencing analysis was performed for all primers. The characteristics of the primers and amplicons for all 19 SNPs are shown in
Thermal cycling was performed according to the following protocols: initial denaturation: 10 min at 95°C, 35 amplification cycles of: denaturation: 30 sec at 95°C; annealing: rs1045642, rs1128503, rs2032582 (ABCB1/MDR1) 30 sec at 54°C; rs6714486, rs2741045, rs2741046 (UGT1A9) 30 sec at 54°C; rs17868320 (UGT1A9) 30 sec at 58°C; rs1155754, rs11557547, rs11557541, rs11557545, rs11557542, rs11557544, rs11706052, rs11557546 (IMPDH2) 30 sec at 58°C; rs11557540 (IMPDH2) 30 sec at 60°C; rs1049818 (IMPDH2) 30 sec at 66°C; rs1800629 (TNF-?) 30 sec at 56°C; rs1800872 (IL-10)30 sec at 54°C; extension: 40 sec at 72°C, final cycle:10 min at 72°C.
The length of the amplified fragments has been controlled by electrophoresis in 2% agarose gel stained with SYBR safe 100X (Invitrogen).
Purification of the fragments was performed with ExoSAP-IT (Affymetrix) according to the instructions of the manufacturer.
Sanger sequencing PCR was performed with Big Dye Terminator v3.1 Cycle Sequencing Kit (Applied Biosystems) as suggested by the manufacturer.
For each sample, two sequencing reactions were prepared with both forward and reverse primers. Products of the reactions were purified using the kit Centri-Sep Spin Columns (Applied Biosystems), according to the protocol recommended by the manufacturer, and then were analyzed by capillary electrophoresis using AB 3500 Genetic Analyzer (Applied Biosystems). The obtained sequences were evaluated by Cromas 2.33 program and compared with the wild type sequences annotated in GeneBank by the BLAST software.
Sample size analysis was performed by QUANTO program version 1.2.3 (?=5% and power (1-?)=80%). Age and gender composition of the groups was compared by one-way ANOVA test. Comparison between two experimental groups was done by unpaired, two-tailed t-test. Observed heterozygosity (HET observed) and expected genotype frequencies in Hardy-Weinberg equilibrium (HWE) were calculated for each SNP, in each group. The deviation from HWE (HWE p) and differences in allele and genotype frequencies were tested by a chi-square test. Candidate gene-disease associations including, per-Genotype , per-Allele and linear trend tests were performed by SAS software Version 9.4 (SAS Institute Inc., Cary, NC, USA).
The clinical characteristics of the groups are summarized in
220 individuals were included in the study. All patients received a standard immunosuppressive therapy: calcineurin inhibitors, mycophenolate mofetil and steroids were given.
The average age of the studied population is 53.1 years. There is a statistically significant difference in the median age (p25th-p75th) between the three groups.
In the study 63 females and 157 males were enrolled. There is a statistically significant difference in the gender composition between the three groups (p < 0.01).
Observed heterozygosity and the deviation from the heterozygosity expected in Hardy-Weinberg equilibrium were calculated for each SNP separately for each group. Values are shown in
In the Control I and II groups, the corresponding p values are above 0.05 indicating a stable equilibrium for each polymorphism. In the Case group rs1045642 of ABCB1/MDR1 is not in HWE (indicated with bold letter). When a disequilibrium is not due to a technical error, the statistical evaluation of the data should involve statistical tests using genotype frequencies rather than allele frequencies (5, 7).
The observed allele frequencies in the three groups compared with that of the European population and all races (data from Ensemble database) are summarized in
There is a similar trend in the observed genotypes frequencies in all three groups, reported in
No transplant patients with acute rejection are A/T heterozygote for rs2032582 of ABCB1/MDR1; as no healthy individuals are A/T or A/G heterozygote for rs2032582 of ABCB1/MDR1. No individuals in the Control I and II groups are G/G homozygote for rs11706052 of IMPDH2.
We analyzed all SNPs per-allele, per-genotype and we performed linear trend test between all three groups. The results are summarized in Figure 12, 13 and 14. The p values are above 0.05 for each polymorphism indicating that there are no statistically significant differences between Case and Control I groups (
Comparing all transplant recipients (Case + Control I) and healthy individuals (Control II), G allele at rs1800872 positions of the IL10 gene may indicate an increased probability (p=0.06) to develop end stage kidney disease that requires renal transplantation as a final solution (
Since patients currently without acute rejection events may have acute rejection episodes in the future we also compared Case to Control II group (
The examined genes and analyzed SNPs are involved also in acute rejection episodes following different types of organ transplantations, thus we believe that our results would be of interest not only to the experts in kidney transplantation but to all clinicians working for transplantation teams.
Characteristic SNP patterns of genes involved in immune responses and in the pharmacokinetics/pharmacodynamics of immunosuppressive drugs related to acute renal rejection episodes are in the focus of our on-going study. In this paper we present our preliminary results about the complex SNP profiles of kidney transplant recipients, highlighting some important genetic variants predisposing to acute rejection events. However, these findings should be considered as observations rather than statistical conclusions due to the modest number of transplant patients with acute rejection episodes in the Case group (The low number of patients with acute rejection events, in clinical aspects, is a success.) Therefore, we continue our study involving new patients also from other centers.
The age and gender composition of the three experimental groups were statistically different. Healthy people, without any known or generally checked diseases in the control II group were little younger than in the two other groups due to technical issues. In addition, more male patients needed transplantation than female patients. The literature supports the male prevalence of Chronic Kidney Disease (CKD) (9). This gender difference is also noted when acute rejection happens. Hence the gender composition in the Control II group was chosen to be similar to the other groups, rather than to be almost equal between males and females.
The observed allele frequencies in the Control II group are in line with ones reported from Europe indicating that the studied population is representative.
All SNPs for IMPDH2, with the exception of rs11706052, seem not to be polymorphic since only one allele was found with the sequencing analysis. Other groups have published similar results (10, 11) hypothesizing that those SNPs, found also in public, online databases (Entrez, Ensembl) are artefacts of previous, not so accurate sequencing techniques. Thus, these SNPs were removed from further analysis.
The genotype distribution of the experimental groups partially overlaps. However, no transplant patient with acute rejection is A/T heterozygote for rs2032582 of ABCB1/MDR1; and no healthy individuals are A/T or A/G heterozygote for rs2032582 of ABCB1/MDR1. No individuals in the Control I and II groups were G/G homozygote for rs11706052 of IMPDH2.
In the study population all examined polymorphisms are in Hardy-Weinberg equilibrium (HWE), except the rs1045642 of ABCB1/MDR1 in the Case group. Since HWE is violated, statistical methods using allele frequencies may not be valid and methods that use genotype frequencies are preferred (7), therefore both allele and genotype frequencies were calculated and used for further gene-disease association analysis.
The genetic associations calculated per allele, genotype and linear trend test do not verify statistically significant differences between all transplant patients (Case + Control I) and healthy controls (Control II). However, comparing Case and Control I groups, the rs1045642 of ABCB1/MDR1 gene has the p value equal to 0.05 and might be biologically significant. If more patients with acute rejection will be enrolled in the Case group it is very likely that the p value become also statistically unambiguously significant.
Excluding future candidates of rejection events by comparing Case to Control II group, statistically significant differences appear for one SNP of IL-10 and two SNPs of ABCB1/MDR1 gene; meaning that having a G in rs1800872 or a C in rs1045642 or an A in rs2032582 respectively, is a risk for the patients to develop an adverse event after transplantation.
Among the transplant recipients 2 patients are having the risky genotype so far without any rejection event. Therefore in this follow-up period the Control I group is still continuously monitored.
Certain SNPs - like rs1800872 - in the IL-10 gene promoter may influence the binding of several transcription factors and thereby gene expression. Since IL-10 is an anti-inflammatory cytokine, one may suppose that an SNP leading to a reduced expression may enhance inflammation in the target tissues. These speculations had tried to be verified by various studies: association tests on relatively homogeneous population (13) and smaller meta-analysis (14) showed a possible connection between IL-10 gene polymorphisms and acute graft rejection following renal transplantation, but large meta-analysis like by Xiong J et al (15) failed to support these findings.
ABCB1/MDR1 is coding for P-glycoprotein (P-gp), acting as an ATP-dependent pump, exporting drugs out from the cells and thereby reducing drug accumulation within the cells, thus preventing toxicity (10, 16). Immunosuppressive agents, like calcineurin inhibitors are substrates of P-gp, therefore SNPs like rs1045642 and rs2032582 in ABCB1/MDR1, by modifying the effectiveness of the immunosuppressive drugs may put patients at a higher risk to reject the organ. This finding is in line with a previous study about lung transplantation (17), where the C allele of rs1045642 affecting P-gp function was considered as a risk allele - exactly like in our research. We can hypothesize that the change in the codon but not in the corresponding amino acid is influencing the effectiveness of the pump by for eg. post-transcriptionally modifying (via miRNA binding) the amount of mRNA and thereby the quantity of the expressed protein. In case of the gene polymorphism rs2032582 of ABCB1/MDR1 the A allele is coding for a missense mutation that can directly affect the quality and also the quantity of P-gp protein expression. However, no studies yet reported molecular mechanisms behind the differences in genotype and the belonging phenotype so further analysis should be done to confirm these theoretical suppositions.
Since blood levels of immunosuppressants vary between patients, several studies had been investigating the association of drug levels with different ABCB1/MDR1 polymorphisms. So far in European cohorts neither the influence of specific rs1045642 genotype on Tacrolimus pharmacokinetics were shown (18, nor out of target range Tacrolimus blood concentration were found to be associated with rs1045642 or rs2032582 in kidney recipients (19). However, six months following lung transplantation CT variant carriers of rs1045642 in ABCB1 had significantly higher blood Tacrolimus concentrations than CC carriers (20). Therefore also drug blood levels and their associations with the success of the immunosuppressive therapy will be examined in our extended study.
P-gp expressed also in the luminal site of kidney tubular cells and contributes to the active secretion of drugs (21), thus also the role of SNPs in living (22) and deceased (23) donor kidneys was evaluated in some studies, mostly with contradicting results about which genotype can be linked to allograft function and outcomes (24, 25). Donor polymorphisms and their interference with the genetic background of the recipients have not yet been concluded in this study.


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Spaulding forfeits today's hockey tournament game
All other games will take place as scheduled: Merrimack vs. Trinity of Manchester at 2 p.m., Hanover vs. Manchester Central at 6 p.m., and Manchester Memorial vs. Goffstown at 8 p.m.
This holiday-ish weekend is all about America. Get your red, white and blue on and go to a concert; the Granite State is filled with music this weekend. Between that and all of the 4th of July...
All Weekend through Tuesday
Sunday, 8 p.m.
Sunday, 10 a.m. - 5 p.m.,
Monday, 6-9 p.m.,
Tuesday, 10 a.m. - 5 p.m.
Friday, 6 p.m.
Saturday, 7 p.m.
All Weekend
Saturday, 7:30 p.m.
Saturday, 8 p.m.
Sunday, 7:30 p.m.
Friday - Saturday, 7:30 p.m.,
Sunday, 5 p.m.


text:
We present EContent's annual Trendsetting Products list. Each year, we turn to our inboxes, our coverage, and our contributors to find out what products are helping content creators of all kinds stay on top of their game. I hope you find these products as interesting and as potentially helpful as we do!
Each year, EContent magazine compiles a list of the 100 companies that matter most in the digital content industry.
If you are interested in being considered for the EContent 100 click here to submit your nomination.
Jan 13, 2004
Wayport, a provider of Wi-Fi wireless and wired Internet access for business travelers in locations such as hotels, airports, and McDonald's restaurants, has announced that it will offer USA TODAY in digital format for free for three consecutive days to travelers who connect at Wayport-enabled partner locations nationwide, through an agreement with USA TODAY and NewsStand, Inc. In addition, trial customers who purchase a subscription to the USA TODAY Electronic Edition will receive a free $25 Wayport prepaid connection card.
Wayport customers who download the USA TODAY Electronic Edition will receive a digital replica of the newspaper sold at stores and stands nationwide--including every article, photograph and advertisement--for three straight days. The USA TODAY Electronic Edition can be read offline, and readers can search for keywords on any subject throughout a single newspaper and across multiple issues, can zoom in on articles or photos that are automatically re-sized for viewing, and can move through pages and headlines. If trial users wish to obtain regular access to the USA TODAY Electronic Edition, they can subscribe for 26 or 52 week terms and receive a $25 Wayport prepaid connection card.
NewsStand, a digital distributor for newspapers and other print media, provides processing, delivery, ecommerce, and marketing support for USA TODAY and other publications. Wayport and NewsStand plan to reach Wayport's customer base with the Electronic Edition of USA TODAY through Wayport's Wi-Fi and wired network. NewsStand's digital delivery solution allows subscribers to download, via the Internet, an entire publication in traditional print format that can be read offline or online on their computer.
(http://www.newsstand.com), (http://www.wayport.net)


text:
27 X 19In Twinkling Lighted Pre Lit Cute Reindeer Christmas Yard Lawn Decor
- Item condition:
- Used
- Time left:
- 5d
- Price:
- $90.00 Buy It Now
- Best Offer:
- Make Offer
- Shipping:
- Item location:
- Grand Rapids,MI,USA
Item specifics
- Country/Region of Manufacture:
- China
27in height x 19 in wide at the bottom
Gentle used
100% Metal frame
Mixed color of copper,gold,green, red, black and glitters
Good condition
May have loose glitter on frame
Small indent on the nose, hard to see.
Made to last for years
Already assembled, may need Minimum assemble.
Yard stakes included.
I will ship as is, if you are interested in disassemble it for less shipping cost. Please let me know.j
Stunning Volturi Stingray Greyish Custom 4x6 Leather Hard Pool Cue Case Backpack
Price: $875.00


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Information provided by UK Small Business Directory
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Oasis Beauty and Day Spa89 Little London
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