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First Time Visitor?
We hope you find your visit informative and enjoyable and that you will have the opportunity to worship with us soon. We have ministries which serve everyone, providing opportunities for everyone to serve others. We invite all baptized Christians to share the Holy Eucharist with us.
We are one of the largest parishes in the Eastern part of the Diocese of Los Angeles of the Episcopal Church, USA. The Episcopal Church is part of the worldwide Anglican Communion, which recognizes the Archbishop of Canterbury as its spiritual leader.
Child care is available every Sunday, starting at 8 am. Staff members are located via Great Hall to nursery school rooms. Nursery for newborns till 3-4 years old.
Child Care providers for 2017 are Chelaine Taylor
( on right) Teagan Tayor ( left ) and Jennifer Harris- Lesh.
Sunday School for ages 6 years old to middle school is available in classrooms starting at 10 am most Sunday's. To learn more about Youth Formation, please review link YOUTH.
>>>PLEASE Note: No Sunday School or Atrium Entire Month of July
Both Reopen on August 6, 2017 <<<
After each Sunday service, please join us for fellowship: coffee/tea and donuts in Great Hall!
June 24, 2017
8:00 AM - Spoken Eucharist
Rite I
10:00 AM - Children's Sunday School
10:15 AM - Choral Eucharist
Rite II
Morning Prayer in the Library
8:30 am
Healing Prayers 11 AM
& Eucharist at 11:30 AM
Centering Prayer 6 p.m.
5:30 PM - Evening Prayer
Bangladeshi Eucharist
10:30 a.m.
July 2, 2017
Room 12
Celtic Monthly Service
Cancelled for June
Trinity Office Hours
Monday and Thursday
9:00 AM to 1:00 PM
Tuesday and Wednesday
9:00 AM to 5:00 PM
Closed Friday
and all holidays
Upcoming Trinity
Community Events
July 14, 2017
Ushering at Redlands Bowl 6p.m.
TENS Starts August 17, 2017 at 9 a.m.
Our Parish Community
Come to the About Us section to meet the staff of Trinity, and find out what we're all about!
What is the Episcopal Church?
Find out about the Episcopal Church and the history of this wonderful community on our What is the Episcopal Church page.
Members Login


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Content count65
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About Travis
- Birthday 05/24/1980
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Profile Information
- Gender Male
- Location Ohio
- Vehicle 2000 jeep cherokee sport 2000 ford ranger splash
Right! The ultimate goal is a second sub and walling it off. Im clipping my amp to get the output from the sub. Going to a bigger amp should give me the output mine cant produce without forcing it to clip.
Well talked to dc. Turned the gain down to about a quarter. No more smell but box is too big and way underpowered now. So gotta get at least a 7k to not have to work so hard to power the monster now. Thanks for the imput everyone. Havnt put much time on here lately due to my insane work hours now in the mill. New box is coming and looking at amp options now. It never ends.
Very. It calls for 5 to 5.5 cubes. I turned the gain down to a quarter. It was at half. I checked the ohm load at the amp and its at 1 exactly not on of course. Ive had to break in 3 different subs for friends in the last few months and they got stinky after an hr or so. Nothing like this. Im hoping its the box too big. Havnt got a chance to get it out of the box to double check everything. I found these sweet reducers that allowed me to get both 8 gauge direct leads in and have a single 8 out. All heat shrunk and zip tied. Its only been in a day and a half. Im calling dc to be safe. Cost way too much not to.
Ok sub is in but something doesnt seem right. Gets stinky very fast. Like within a minute. Checked the coils when it showed up. One was at a 1.7 and the other was 1.5. Was supposed to be dual 1. But i realize they sit higher on a new sub. Going to pull it and check everything. But cant do it alone too damn heavy. I know the box is too big but any suggestions? If anything else im calling dc tomorrow.
Travis posted a topic in General AudioIm in shock of the sheer size of this thing. The weight and magnet are almost comical. Really wish posting pics was easier.
Travis replied to nem's topic in Off TopicHappy birthday!
Aaron even tho i went dc for my sub best believe im gonna order more/bigger amps and my own ssa meter. That thing is sweet!
Well i know the weak link now is in the front battery and my roof for sure. Theres zero sound deadaning in the jeep right now and im really trying to figure out what im gonna do with my roof. I really want to just glass it but that will be such a huge undertaking. And thank you jcarter. Im still grinning!
Finally got on my buddys ssa meter last night since the rebuild. Sealed on the dash im getting a 146.4 drivers window down a 147.9. Both at 35hz. I unfortunatly forgot to put my rear seat down and last time it was worth .6 on the meter. Im pretty stoked! Got a little more wiring to do and a new sub and box to build but the rewire was good for 2.5 db
Travis posted a topic in Subwoofers / SpeakersHello all. New sub is being built as we speak (went full carbon fiber cone and dustcap also). Dc suggests 5.5 cubes but im wondering if anyone else has had some experience with these things to give me the right direction to head. The current box is about 7.5 cubes net so a new box is in order. Will also be going up in power soon. Sub will be on a synergy 35.1 at .5 until i can get a bigger amp. It will be daily but also the occasional competition.
Travis replied to Travis's topic in Subwoofers / SpeakersWell its ordered. None of the above tho. Went with a dc level 6 m4 18 full carbon fiber cone and dustcap upgrade. Anxious to see what a large chunk of cash just bought me for one sub...
Travis replied to Travis's topic in General AudioVery true. I just wondered if somebody had an inside scoop. Itll just have to be my christmas in july!
Travis posted a topic in General AudioWhats happening at the build house that everything has an eta of july i believe? A little dissapointed by this... are they that swamped?
Travis replied to Travis's topic in General AudioI had the chrome ppi 4400 i should have never let go. I may try and get it back

subset: commoncrawl


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Kamik Snowbug4 Snow Boot in Black/Purple
$ 45.99
Sorry, this item is out of stock
Kamik Snowbug4 Snow Boot in Black/Purple.
Item #: NK9055 BPU.
No sales tax!
Product Details:
- Your little Snowbug will love the comfort and warmth of their boots from Kamik® Kids!
- Weatherproof quilted 210D nylon upper.
- Extra wide gaiter and elastic hook-and-loop strap make it easy to get this boot on and off.
- Fixed foam insulation and soft faux-fur lining adds warmth.
- Lightweight and waterproof synthetic rubber shell.
- SNOWPAW Synthetic RubberHE outsole provides excellent traction in snowy conditions.
Fit: Winter boots tend to run small. For best fit, we recommend purchasing a size larger than you typically purchase. Available in whole sizes only, for half sizes please order the next size up.


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"My soul is full of longing
for the secret of the sea,
and the heart of the great ocean
sends a thrilling pulse through me."
― Henry Wadsworth Longfellow
This large one-off piece is painted in acrylics on canvas. It comes with a signed certificate of authenticity from the artist and is ready to hang.
Acrylic on canvas
Acrylic painting by Markus Newman
Acrylic paintingby Markus Newman
Pencil drawingby Markus Newman
Oil paintingby Markus Newman
Acrylic paintingby Markus Newman


text: Out of all the minsu, our best stay was at Hao Wang Jiao Minsu (好望角民宿). We chose to stay here because we didn't feel like staying at Flying Cow Ranch itself and this minsu was situated close to the ranch. It is owned by a very warm, helpful and friendly couple. The wife is called Mary (瑪莉) and we liaised... More


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Dog Sitting Opportunities - Auckland, New Zealand
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Completed House Sits
Pet sitter needed for two dogs in my home ...-Auckland, New Zealand
We are a couple in our 60s, looking for a house sitter in August for two weeks ...House sitter found
Parnell (Central Auckland) House and Dog Sit-Auckland, New Zealand
We are a young couple living in Parnell, Auckland, seeking a house and dog sitter whilst we ...House sitter found
House & dog sitter required-Auckland, New Zealand
We are a mother and daughter looking for a non-smoking house sitter while we travel on our ...House sitter found
Dog sitter for big loving dog-Auckland, New Zealand
We're a family of 4 that live in a lovely home in Glendowie. We have a boisterous ...House sitter found
Fab central apartment with gorgeous active dog-Auckland, New Zealand
Mid-thirties couple with a large ground floor apartment in a block of 4 centrally located in a ...House sitter found
Holiday Weekend Chihuahua Sitting-Auckland, New Zealand
Hi...we love our sweet dog Bananas & normally take her with us wherever we go. Unfortunately not ...House sitter found
Dog sitting
In exchange for a free retreat
More on Auckland, New Zealand
Searching for free accommodation in Auckland, New Zealand? Have you thought about the financial benefits of house sitting in Auckland during your stay? Join TrustedHousesitters.com and connect with home owners willing to offer you the chance to live rent free in Auckland next time you visit.
It's easy to find a house sitting assignment in Auckland when you're registered with TrustedHousesitters.com. We connect travellers with home owners in need of property and pet care, the concept is a perfect exchange and benefits all involved.
Whether you're looking for a funky apartment in Ponsonby, or a family retreat in the leafy suburb of Titirangi, TrustedHousesitters.com is the best place to start your search.
Think you've got what it takes to become a house sitter and secure free accommodation when you travel? Sign-up with TrustedHousesitters.com today and apply for the Auckland house sitting assignments in the list below.
Avoid paying for costly hotel rooms and self-catered accommodation when you visit Auckland. Choose to secure a house sitting assignment through TrustedHousesitters.com, and you'll see the city through the eyes of a local instead of simply following the well-trodden tourist trail.
Take to the skies and soak in the sparkling blue waters and emerald islands of the Haruaki Gulf, or hike to the top of Auckland's volcanoes (Rangitoto and Mount Eden) that offer unparalleled views of the city. You'll soon realise why more than one quarter of New Zealand's entire population has chosen to make their home in Auckland.
Search for a house sitting assignment in historic Parnell. Packed full of charm and character you could spend your days browsing the high-end boutiques, indulging in artesian produce on offer at the French markets, or relaxing in a stylish cafe.
If you're looking for a budget stay in Auckland search for a house sitting assignment among Auckland's western suburbs. Just 40 minutes or so from the city you'll find a wealth of green and leafy suburbs with the wild west coast beaches and boutique wineries close at hand.
Join TrustedHousesitters.com today and secure a house sitting assignment in Auckland to reduce the cost of your visit to New Zealand's North Island.


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I am very happy of my stay to Asokam Beach Resort.
It is a wonderful place with really kind people.
A lot of kindness, seriousness and professionalism for all the team of the hotel: a very competent doctor and therapists, a staff always oriented to our needs. The very thoughtful Manager and the excellent cooking of his wife are unforgettable. I keep of it a wonderful souvenir.
Ghislaine from France
- Official Description (provided by the hotel):
- Enjoy fine hospitality in Kannur at ASOKAM BEACH RESORT HOTEL on the shore of Payyambalam beach. Asokam Beach Resort provides a clean, calm and relaxing atmosphere. With the soothing sound of waves and clear air the resort is an ideal get away from hectic and stressful life. The Ayurvedic center complements the demand for treatments, relaxation, and rejuvenation. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Agoda and Priceline so you can book your Asokam Beach Resort reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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"Why, yes. I did just lick sweaty post-run salt off you while you napped.
Is that a problem?"
Today I embraced my inner squirrel
I'm working on a synopsis for my work-in-progress and, as anyone who has ever written one can attest, it's not a pretty process. This time around I'm writing a synopsis before writing the novel which means I'm not locked into anything.
Or another way to describe it: SQUIRREL BRAIN FREE-FOR-ALL
My ADD tendencies are having a blast-y as I try to reconcile my rough outline with all the brand new shiny ideas firing in my brain.
However, I did make progress today. And when I'd had enough of ye olde synopsis, I put Emma on her leash and we went for a run on the trails.
Nothing clears the squirrel from one's brain like a run over uneven terrain.
Thankful Thursday: Emma of the short legs
Sunday Confessional: The today-I-parched-my-dog edition
I went out on the trails with Emma today. It was sunny and warm (probably about 80 degrees), there was substantial elevation gain, and we ran when we could.
Another pertinent fact? I didn't bring water.
When we got off the trail and back on the street, we'd gone about 2.75 miles and Emma's tongue was hanging out. We walked about 150 yards and then hit a patch of shade. She flopped onto her belly, legs splayed behind her, and panted. I let her stay down there while I stretched, and then got her going again. Several patches of shade later, she did the same thing. Belly flopped.
So I picked her up and carried her.
We passed some guy who asked, "Isn't she supposed to be walking?" Nope. It was totally my bad. I overexerted my short-legged dog in the heat AND neglected to bring water. Two belly flops from her meant the rest of the way home was on me.
So I carried the 25-pound dog the last half-mile. For the record, she completely enjoyed the ride, looking around from her new vantage point.
She's still a bit tuckered, though. While she rested, I dug my water pack out of the closet to use on our next outing.
Friday Haiku
Happy Windsday, Piglet
Thankful Thursday: The sunshine edition
This is Zippy's indoor weather station. As you can see, it's sunny and 65 degrees outside. Granted, the outdoor thermometer is in direct sunlight right now so it's really only 65 degrees against the bricks on the south side of the house. But still. Sixty-five degrees in January!
I'm going out for a run around the neighborhood and am looking forward to cruising past the snow piles lingering from last weekend's storm.
Gotta love Colorado and its split-weather-personality.
Pity party interruptus
Last week I was in Florida and while there, I went running for the first time in a month. As a result of all those weeks off, I ran slower than usual.
When I hit the 3-mile mark, I stopped running and began my cool-down walk. Almost immediately my brain started beating me up: you're used to running at elevation and this was running at sea level! You're used to running up and down hills, and this was running on mostly flat! You're slow, slow slow. Old, old, old. Sad, sad, sad.
As I walked on the path through the woods, I regretted the health issues that had prevented me running. I regretted losing the fitness level I'd worked hard to achieve. I regretted my loss of muscle, stamina, and lung power.
I admit to feeling a wee bit defeated.
Then there was a WHOOSH and SQUAWK as something dropped from the tree above and landed next to my feet: Two woodpeckers, one on the back of the other, briefly wrestled on the path before separating and flying off to different trees.
And just like that, my mood lifted. I realized I was going to be all right. I knew I'd regain my strength, just as I knew that it was a gift to be able to up and run three miles after time off. How could I not know?! I'd just witnessed the miracle of wrestling woodpeckers!!!
Sometimes the universe gets sick of our whining and drops a big ol' SNAP OUT OF IT sign in front of us.
I'm grateful I could see past the pity party to read it.
Neighborhood steeplechase
I've been having some health issues so took three weeks off from running. During that time I did a lot of speedwalking around the neighborhood and while it got my heart pumping, I felt wistful whenever people ran past me. I need to run.
So it was a big HOORAY on Monday when Zippy and I did a short run around the neighborhood! We timed today's run to end just minutes before the Olympics men's final 3000m steeplechase and in preparation for watching that race, I spent my run scanning for potential hurdles and water jumps. There was a little runoff in one of the streets and I'm pleased to report that I cleared that water no problem!
We finished our run and watched the men's final, cheering on all the athletes. Evan Jager from (one of) my alma mater, UW-Madison, won silver today. A few days ago we saw Emma Coburn from Zebu's alma mater (UC-Boulder) win bronze. Such inspirational races.
Maybe I should start hurdling the boulders next to the trails!


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Are you planning on having kitchen renovations done to your home? If so, it is important that you have new electrical wiring installed for the lighting, outlets and any amenities that you plan on installing in your kitchen. Failing to have your electrical wiring installed correctly can cost you in city fines and create many safety hazards, which is why it is a must to hire a local electrical contractor.
With services from an electrical contractor, you can be confident that your new kitchen is set up correctly, as your contractor can:
1. Install and Organize Cables
Having organized cables is always helpful because if anything were to occur to your electrical system later on, organized cables will make it easier for you to find the issue. Not only will your electrical contractor be able to label and tidy up the cables behind your walls, but he or she will be able to securely disable any live wires that are not running into any outlets or lighting fixtures. This will ensure you are able to receive permits from the city since you do not have any live wires that are causing a safety hazard in your home.
2. Set up New Outlets
New outlets need to be properly installed, as it can be a requirement from your city that each outlet is a specific distance from other outlets in your home. Because of this, it can be much better to have a professional install these new outlets, as you will want to be confident that you are following guidelines, and that your new outlets put out the proper amount of electrical current. This will ensure your amenities and electrical devices do not get overpowered and damaged by an outlet that is putting out too much electricity.
3. Install New Lighting Fixtures
Not only will your contractor be able to set up new outlets and run new electrical wirings behind your kitchen walls, but he or she will be able to run electrical cables up the walls and keep them hidden. This will allow you to set up lighting in your kitchen without having exposed electrical cables or poorly installed lighting fixtures. Also, to ensure safety, your electrical contractor will be able to test the electrical output of your lighting fixtures to ensure you install the proper wattage light bulbs into them. This will help prevent your lights from burning out regularly and ensure that you are not using too much energy to operate your kitchen lights.
With services like these, your new kitchen will have a high quality electrical system, which will meet your city's requirements and ensure your electrical system does not pose any dangerous threats to your home. So, rather than attempt to install new electrical cables yourself, you will be much better off with services from a professional, like D & D Electric Enterprises, Inc.


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Davutoglu: Activation of Al-Qaeda and Syrian wing of PKK is threat to Turkey
09 January 2014 [17:45] -
Activation of the international terrorist organization Al Qaeda and the Syrian wing militants (PYD) of terrorist Kurdistan Workers' Party is a threat to Turkey, Turkish Foreign Minister Ahmet Davutoglu said in an interview with Anadolu agency on Jan. 9.
Alien elements must leave Syria, the Foreign Minister said.
The Foreign Minister also stressed that Al-Qaeda and other terrorist groups in Syria appeared at a time when the opposition had strengthened its position in the north of the country.
Davutoglu also said that there is a link between the Syrian regime and terrorist organizations.
During the conflict in Syria which began in March 2011, more than 115,000 people were killed in the country and over 4.2 million became refugees in Syrian territory and two million fled to neighboring countries. The main burden of receiving refugees lay on Iraq, Jordan, Lebanon and Turkey. The total population of Syria before the conflict amounted to 20 million.
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Home > News > A picture-perfect month for nano competition winner
November 22nd, 2004
A picture-perfect month for nano competition winner
Seth Coe-Sullivan was heading to the Cleveland airport in late October after his new company had just received the top prize in a nanotechnology business idea competition. A few weeks earlier, he had taken top honors in the Nikon International Small World Competition.
|Related News Press
Russia's Nano-enabled Products Market to Witness Massive Growth February 8th, 2011
Adept Technology Announces Orders for Over $600K from Chinese Partner January 18th, 2011
Nanostart-held ItN Nanovation Receives Major Follow-on Order in Saudi Arabia November 29th, 2010
Homegrown Companies Developing Batteries for Clean Energy Storage November 2nd, 2010
U.S. Air Force Research Lab Taps IBM to Build Brain-Inspired AI Supercomputing System: Equal to 64 million neurons, new neurosynaptic supercomputing system will power complex AI tasks at unprecedented speed and energy efficiency June 23rd, 2017
Rice U. chemists create 3-D printed graphene foam June 22nd, 2017
Tiny bubbles provide tremendous propulsion in new microparticles research-Ben-Gurion U. June 21st, 2017
Enhanced photocatalytic activity by Cu2O nanoparticles integrated H2Ti3O7 nanotubes June 21st, 2017
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2312 W Fawn Drive, Phoenix, AZ 85041
3 beds, 2 baths, 1,735 sqft
Status: Contingent
Available with Limitations, contact Long Realty for details (Contingent/CAPA)
Property Description
Wow! This 3 bed, 2 bath home surrounded on two sides by greenbelt in a cul-de-sac in Phoenix is a beauty! Highly upgraded and in impeccable condition! Featuring desert front landscaping, 3 car garage, plantation shutters, surround sound in the great room and a den great for an office makes this home move-in ready! Kitchen is equipped with matching appliances, recessed lighting, a breakfast bar, tiled back-splash, granite countertops, pantry, and ample cabinetry with crown molding. Spacious master bedroom boasts a lavish full bath, double sinks, separate tub and step-in shower, and walk-in closet. The charming backyard is comprised of desert landscaping, covered patio with paved sitting area, and a refreshing blue pool and spa perfect for summer. Schedule a showing today!
Listing Information for 2312 W Fawn Drive Phoenix, AZ 85041
Richmond American
SRP,SW Gas
Ceiling Fan(s)
School Information for 2312 W Fawn Drive Phoenix, AZ 85041
Room Information for 2312 W Fawn Drive Phoenix, AZ 85041
Master Bedroom Walkin Closet
Breakfast Bar, Formal, Eat-in Kitchen
Granite Counter-tops, Pantry
Double Sinks,Private Toilet Room,Separate Shwr & Tub,Full Bth Master Bdrm
Dual Sinks, Separate Tub & Shower
Interior Features for 2312 W Fawn Drive Phoenix, AZ 85041
Disposal, Microwave, Electric Range/Cooktop, Refrigerator, Dishwasher, Dryer, Washer
Tile, Carpet
Electric Heating
Double Pane
9 Ft + Flat Ceilings
Exterior / Lot Features for 2312 W Fawn Drive Phoenix, AZ 85041
3 Garage Spaces, 3 Parking Spaces, Electric Door Opener
Stucco, Painted
Covered, Patio
All Tile
Heated, Private, Community Pool
Heated Spa, Private Spa
Silva Mountain Unit 1
Covered Patio(s), Patio, Cul-De-Sac Lot, North/South Exposure, Mountain View(s), Corner Lot
Community Features for 2312 W Fawn Drive Phoenix, AZ 85041
Park Play Area
Silva Mountain HOA
Driving Directions to 2312 W Fawn Drive Phoenix, AZ 85041
Head west on W Baseline Rd, Turn left on 23rd Ave, right on W Branham Ln, left on S 23rd Ln, left on W Fawn Dr, Property will be on the left.
Financial Considerations for 2312 W Fawn Drive Phoenix, AZ 85041
Listing Price History for MLS#: 5616967
Phoenix AZ Real Estate and Phoenix AZ Homes for Sale
Phoenix is located in the state of Arizona. The zip code of 85041 has a population of 1,563,025. The median age of people living in Phoenix, AZ 85041, is 32.9 years.
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Charlotte Bronte
Five Books About…
Five Books About Inconvenient Women
Zen Cho
Tue Sep 8, 2015 4:00pm3 Favorites [+]
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Room was clean except stuff in microfridge.
Queen-sized bed was very comfy especially to my wife.
Continental breakfast was very adequate; waffles, boiled eggs, cereal, bagels, sweet buns/doughnuts, juices, coffee, and milk.
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text: A cutesy, darling and dainty ping poodle dog costume for your little baby. This Halloween, your little baby princess can be become a precious pup in this Pink Poodle costume. The costume includes: A plush pink bodysuit with attached bow, faux fur armbands and matching anklets, and cute character hood with miniature bows. The poodle […] Read more »


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Listen to free music played by Diablo
Blip.fm is internet radio made social. It's easy to search for, play, and discover free music recommended by real people. Join today to create your own free station and start listening to @Diablo.
Diablo Depeche Mode – Nothing to Fear (Robert Wilsdon Remix)
Feb 9, 2013 at 9:00 pm via YouTube | AMAZON | ITUNES


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Explore Photography and more!
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#500px Select #Photography : Untitled by franjo1141 https://t.co/B0962OL66K | https://t.co/ZJIRUWbIfh #followme #photography
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Best Underwater Photography 1. Grand Cayman, Cayman Islands 2. Belize Atolls 3. Exumas, Bahamas 4. Riviera Maya, Mexico (pictured) 5. St. Croix, U.S. Virgin Islands eastern side of the Yucatan Peninsula, ramble down coastal Highway 307 through Quintana Roo to some of the best dive sites in Mexico. Playa del Carmen world-class drift diving at Palancar Reef & Columbia Wall , plus bull-shark dives. It is also reach remote Chinchorro Banks. Freshwater caverns scubadiving.com/rivieramaya
Gorgeous Horse horse photography #horses
If you're looking to explore the world of macro photography, these tips will help you get started.
Disney inspired baby photography photo shoot. Mickey mouse newborn walt disney disney world minnie mouse baby florida
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Crystal McCahill
There are not that many babes like gorgeous model Crystal McCahill, that is for sure. Her nipples are rock hard and her cunt is getting wetter all the time as she is posing for the camera with pleasure. Black lingerie is amazing.25 Jan, 2013
Amber Nicole
Cute Amber Nicole is a long haired model who always gets horny when the camera turns on. Her soft nipples get rock hard in no time and her slippery beaver gets totally wet and ready for hardcore pounding all night long.08 Nov, 2011
Jaime Pressly
Jaime Pressly is a cute brunette babe who has a nice rack and is a cute looking lass. How amazing is she. Then she goes outdoors and she is playing around but she also shows off her nice ripe breasts. She is a very stunning.05 Dec, 2014
Viktoria Sweet
Cute and super horny... That is the best way to describe gorgeous long haired Viktoria Sweet, who is always in the mood to push her tight ass out and show that beaver... It is amazing how horny she is all the time...16 Jan, 2012
Gabrielle Ford
We all know that the hottest babes are posing for the Playboy cameras and blonde Gabrielle Ford is one of them. Her round natural firm peaches are making her look even more attractive as she is teasing us and stripping.09 Aug, 2012
Skylar Hart
Sensual, delicious, always ready to please and show off her perfectly shaped body... That is what gorgeous model Skylar Hart has to offer. You are going to love her tight sexy round butt as she is posing nude on the bed.29 Apr, 2013


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What's the best story you know about your dad? by DuhSude in AskReddit
Sleepyhe@d - "Here I Stand (Prod. VNM)" [Original] (self.hiphopheads)
submitted by sl33pyhead to r/hiphopheads
Where can I find beats? by Flappach in rap
17 year old rapper from Brooklyn, Making buzz dope or nah? by in altrap
Share the best Yo mama jokes you remember? (NSFW) by DroidsRugly in AskReddit
Can contracted words such as 'I'll' and 'I'm' stand by itself as an answer? by SwimmingHorses in linguistics
"These Pigeons Look Like They're About to Drop the Hottest Album of 2014" (self.hiphopheads)
submitted by sl33pyhead to r/hiphopheads
Who is the worst hip-hop artist/song that you have ever heard? by AmericanMeat in hiphop
Any Blu & Exile fans? BELOW THE HEAVENS (2007) is getting reissued. by jsnk in hiphop
[–]sl33pyhead -1 points0 points1 point (0 children)
Snoop Dogg performed in front of Obama last week by plurntup in hiphopheads
What rap song has the deepest meaning to you?Like a song that just made you go "wow" for the first time. by rosser16 in hiphop
The Pharcyde - Runnin' by Apprentice_65 in hiphopheads
Gucci Mane just dropped a new album over Twitter called 'DIARY OF A TRAP GOD' by in hiphopheads
"Anyone who felt they needed to write a response to Kendrick's 'control' verse already lost." - Flying Lotus by frickingenius in hiphopheads
Mr. J. Medeiros - Silent Earth (youtube.com)
submitted by sl33pyhead to r/hiphopheads
What is the most BS piece of advice adults give to children? by wcrbarker in AskReddit
Like Chance the Rapper - 10Day/ACIDRAP? Have some Vic Mensa - Orange Soda by Newtstradamus in rap
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[–]sl33pyhead[S] 0 points1 point2 points (0 children)
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[–]sl33pyhead 106 points107 points108 points (0 children)
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[–]sl33pyhead[S] 0 points1 point2 points (0 children)


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I am so pleased to announce that my retail line of glazes and mustard are available in a few stores possibly near you! And if I'm not in your neighborhood yet I'm working on it and appreciate any helpful hints as well!!
Grapevine, TX
Texas General Store
406 S. Main Street
Grapevine, TX 76051
McKinney, TX
Loco Cowpoke Salsa Shop
206 E. Louisiana Street, #102
McKinney, TX 75069
Nacogdoches, TX
Granary St Natural Health Food Store *carries selection of jams/jellies, does not include retail products shown*
4411 South Street
Nacogdoches, TX 75964
Heart of Texas Gift Gallery
110 S. Pecan Street
Nacogdoches, TX 75964
Palestine, TX
Granny Muffin Wines
301 W. Oak Street
Palestine, TX 75801
Tyler, TX
Sweet Gourmet
French Quarter Shopping Center
4554 S. Broadway Avenue
Tyler, TX 75703
Country Meat Market
2308 E. Front Street
Tyler, TX 75702


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8085 East 28th Avenue Denver, CO 80238
Hi, Brian and Aimee DeLuccio.
My name is
and I have a question about 8085 East 28th Avenue Denver
You can respond by either emailing me at
or call during
My Question Is:
Estimated Monthly Payment$5,051
- Photos
- Location
- Questions
- Share
- Mortgage Calculator
- Status: Pending
Listing courtesy of RE/MAX Cherry Creek
HIP STAPLETON CONDO ACROSS FROM COMMUNITY POOL*HICKORY HARDWOODS ON MAIN LEVEL AND UP THE STAIRS INTO THE LOFT*EN-SUITE MASTER*NEW TILE IN ENTRY WAY AND IN LAUNDRY*NEW CONCRETE COUNTER TOPS & APPLIANCES WITH CROWN MOLDING IN KITCHEN*UPDATED LIGHT FIXTURES*ALL NEW KOHLER LAVATORIES*EASY TO SHOW* Stapleton transfer tax(sales price-$100K)*.25%
Interior Features Include:
Fireplaces 1, Cable Available, Double Pane Windows, Eating Space / Kitchen, Master Bath, Master Suite, Open Floor Plan, Pet Free, Updated, Vaulted, Window Coverings
Air Cond: Air Conditioning-Central
Heating: Forced Air
Heating Fuel Gas
Floor Type: Carpet, Wood Floors
Exterior Features Include:
Balcony, Maintenance Free Exterior, Yard
Acreage: 0.0000 Acres
Roof: Composition Shingles
Garage Capacity: 1
Other Features Include:
Community: Stapleton
Kitchen Appliances Cook Top, Dishwasher, Disposal, Microwave Oven, Refrigerator (Kitchen), Stove/Range/Oven
Water: Public
Sewer: Public
Association Fee 40.00
Association Fee Frequency Monthly
Association Fee Includes Community Pool, Exterior Maintenance w/ Roof, Insurance, Recycling, Sewer, Snow Removal, Tennis Courts, Trash Removal
Number of Floors 2
School District: Denver 1
The DeLuccio Gold Team
Cell: (303) 470-9800
Work: (303) 946-1818
The content relating to real estate for sale in this Web site comes in part from the Internet Data eXchange ("IDX") program of RE Colorado, INC. Real estate listings held by brokers other than owners of this website are marked with the IDX Logo. This information is being provided for the consumers' personal, non-commercial use and may not be used for any other purpose. All information subject to change and should be independently verified. Complete Metrolist Disclaimers and Disclosures


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Capitalism has played a dual role in the path to sexual liberation. On the one hand, it has inhibited progress by ideologically thrusting people into the heterosexual family, which has been enshrined as a source of security and love. Hence, many have long held that any challenge to this institution was by default typically anti-capitalist, and thus that lesbian and gay subcultures are inherently radical. On the other hand, capitalism plays another role: it provides avenues for sex in superabundance, and thus can be seen as facilitating progress toward sexual freedom.In the wake of a string of victories for gay marriage movements in the west – a signal for many that LGTBQs are indeed 'winning' the battle by redefining the family – David Alderson's Sex, Needs and Queer Culture offers a timely and much-needed critique of 'gay liberation'.
Alderson offers a carefully constructed, critical analysis of contemporary notions of sexual freedom in the historical context of a nascent neoliberal capitalism and era of flexible accumulation. He addresses the processes by which the initial radicalism of sexual liberation of the 1960s gave way to the relatively conservative agendas of marriage and adoption rights. At the same time, he challenges the notion that this transition was in any sense disloyal to its revolutionary roots. Among his many observations, Alderson points out that while '[queer] radicals often like to remind the organisers of contemporary mardi gras-style Pride events that Stonewall was a riot . . . it was first of all a bar'.
By re-examining the works of Herbert Marcuse in relation to cultural theorists Raymond Williams, Marianne DeKoven and Alan Sinfield among others, Alderson outlines the historical shifts that have led to the current economic and cultural conditions (a 'diversified dominant') within which sexual dissidents have been assimilated. From a socialist-humanist perspective, Alderson thereby stitches together a framework that aims to re-evaluate the radicalism and efficacy of queer counterculture and rebellion.
Alderson acknowledges that his work focuses primarily on the gay male experience. But in addition to largely overlooking the role of gender, he also fails to consider the processes of colonialism and racism. This becomes particularly problematic when he makes reference to non-British or American examples of sexual liberation.
Nevertheless, the exceptionality of Alderson's contribution is his placement of the sexual in close proximity to the economic.
When fire safety has become a privilege for the rich, it's time to stop austerity and fund emergency mass works to raise standards immediately, writes Jane Shallice
The election result has irreversibly changed political discourse in the UK, writes James Fox
In commemoration of the 30th anniversary of Bernie Grant's election to parliament, Ayo Wallace explores the life and legacy of his radical representation of Tottenham's black communities.
Across Britain, hundreds of thousands of people have now taken part in mass rallies for Corbyn's Labour. Eli Regan soaks up the atmosphere in Warrington
The under-30s could be decisive in the general election. Frances Grahl meets young people hit by Tory austerity and looks at what's driving their support for Labour
"To them it's just another number, someone else being sent back. But when you've got three children being left without their dad … it's quite major," writes Rebecca Omonira-Okeykanmi.
Hundreds of people surrounded the fences this weekend. Hera Lorandos spoke to women who have suffered inside.
Grassroots posters giving an alternative take on the general election
Laying out the case for Labour's leadership of a Progressive Alliance, Jeremy Gilbert argues that far from posing a threat to the Left, the Progressive Alliance offers a golden opportunity to end Tory rule and build a 21st century government committed to social justice
The Greens have stood down in Brighton Kemptown to clear the way for Labour, and the Lib Dems won't stand in Brighton's other seat, Green-held Pavilion. Davy Jones, who would have been the Green candidate in Kemptown, says this shows the way forward
Jeremy Corbyn is no longer the leader of the opposition – he has become the People's Prime Minister
While Theresa May hides away, Corbyn stands with the people in our hours of need, writes Tom Walker
In the aftermath of this disaster, we must fight to restore respect and democracy for council tenants
Glyn Robbins says it's time to put residents, not private firms, back at the centre of decision-making over their housing
After Grenfell: ending the murderous war on our protections
Under cover of 'cutting red tape', the government has been slashing safety standards. It's time for it to stop, writes Christine Berry
Why the Grenfell Tower fire means everything must change
The fire was a man-made atrocity, says Faiza Shaheen – we must redesign our economic system so it can never happen again
Forcing MPs to take an oath of allegiance to the monarchy undermines democracy
As long as being an MP means pledging loyalty to an unelected head of state, our parliamentary system will remain undemocratic, writes Kate Flood
7 reasons why Labour can win the next election
From the rise of Grime for Corbyn to the reduced power of the tabloids, Will Murray looks at the reasons to be optimistic for Labour's chances next time
Red Pepper's race section: open editorial meeting 25 June
On June 25th, the fourth of Red Pepper Race Section's Open Editorial Meetings will celebrate the launch of our new black writers' issue - Empire Will Eat Itself.
After two years of attacks on Corbyn supporters, where are the apologies?
In the aftermath of this spectacular election result, some issues in the Labour Party need addressing, argues Seema Chandwani
If Corbyn's Labour wins, it will be Attlee v Churchill all over again
Jack Witek argues that a Labour victory is no longer unthinkable – and it would mean the biggest shake-up since 1945
On the life of Robin Murray, visionary economist
Hilary Wainwright pays tribute to the life and legacy of Robin Murray, one of the key figures of the New Left whose vision of a modern socialism lies at the heart of the Labour manifesto.
Letter from the US: Dear rest of the world, I'm just as confused as you are
Kate Harveston apologises for the rise of Trump, but promises to make it up to us somehow
The myth of 'stability' with Theresa May
Settit Beyene looks at the truth behind the prime minister's favourite soundbite
Civic strike paralyses Colombia's principle pacific port
An alliance of community organisations are fighting 'to live with dignity' in the face of military repression. Patrick Kane and Seb Ordoñez report.
Greece's heavy load
While the UK left is divided over how to respond to Brexit, the people of Greece continue to groan under the burden of EU-backed austerity. Jane Shallice reports
On the narcissism of small differences
In an interview with the TNI's Nick Buxton, social scientist and activist Susan George reflects on the French Presidential Elections.
Why Corbyn's 'unpopularity' is exaggerated: Polls show he's more popular than most other parties' leaders – and on the up
Headlines about Jeremy Corbyn's poor approval ratings in polls don't tell the whole story, writes Alex Nunns
Job vacancy: Red Pepper is looking for a political organiser
Closing date for applications: postponed, see below
The media wants to demoralise Corbyn's supporters – don't let them succeed
Michael Calderbank looks at the results of yesterday's local elections
In light of Dunkirk: What have we learned from the (lack of) response in Calais?
Amy Corcoran and Sam Walton ask who helps refugees when it matters – and who stands on the sidelines
Osborne's first day at work – activists to pulp Evening Standards for renewable energy
This isn't just a stunt. A new worker's cooperative is set to employ people on a real living wage in a recycling scheme that is heavily trolling George Osborne. Jenny Nelson writes
Red Pepper's race section: open editorial meeting 24 May
On May 24th, we'll be holding the third of Red Pepper's Race Section Open Editorial Meetings.
Our activism will be intersectional, or it will be bullshit…
Reflecting on a year in the environmental and anti-racist movements, Plane Stupid activist, Ali Tamlit, calls for a renewed focus on the dangers of power and privilege and the means to overcome them.
West Yorkshire calls for devolution of politics
When communities feel that power is exercised by a remote elite, anger and alienation will grow. But genuine regional democracy offers a positive alternative, argue the Same Skies Collective
How to resist the exploitation of digital gig workers
For the first time in history, we have a mass migration of labour without an actual migration of workers. Mark Graham and Alex Wood explore the consequences
The Digital Liberties cross-party campaign
Access to the internet should be considered as vital as access to power and water writes Sophia Drakopoulou
#AndABlackWomanAtThat – part III: a discussion of power and privilege
In the final article of a three-part series, Sheri Carr gives a few pointers on how to be a good ally
Event: Take Back Control Croydon
Ken Loach, Dawn Foster & Soweto Kinch to speak in Croydon at the first event of a UK-wide series organised by The World Transformed and local activists
Red Pepper's race section: open editorial meeting 19 April
On April 19th, we'll be holding the second of Red Pepper's Race Section Open Editorial Meetings.
Changing our attitude to Climate Change
Paul Allen of the Centre for Alternative Technology spells out what we need to do to break through the inaction over climate change
Introducing Trump's Inner Circle
Donald Trump's key allies are as alarming as the man himself


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Audio engineer and music devotee relying on my creativity and diverse set of skills to make great sounding tracks and help artists achieve their creative vision.
Big Fish
I'm an italian multiplatinum producer who has worked for pop, rap and electronic music artists, internationally (e.g. Diplo, Anastacia) and in Italy (e.g. Elisa, Fabri Fibra, Emis Killa). I own Doner Music, label and management of bass music/edm producers.
Recording Studio
Been doing this for 30 years. Love it with all my heart. Produce, Compose, Engineer, Mix, Play, Conceptualize, Market, Sell... We do what you need.
REZMUSIC™ - Custom Music Production Escape The Ordinary and Tell Us About Your Project Today! Custom Music Production - Tracking - Mixing - Mastering - Songwriting - Film Scoring www.rezmusic.net
Sean Kidder Productions
I mix music in a different way that keeps the listeners attention.
Kavishka Dombawela (Born November 10, 1995), known by his stage name K2 is a Sri Lankan electronic music producer. Starting at the age of 11 years to produce music , Kavishka currently produces music under The alias K2 (K-Records). Music Composing Software "FL Studio,Cubase,Ableton Live,Reson,Logic Pro x Genres EDM Dubstep Electro House Hardcore
Syft Studio
Welcome to Syft Studio, where great hits are made!
MDS Sound Engineering
We specialize in multi-instrumental performance, sound engineering, design, mixing and mastering out of Barrie, Ontario, Canada. Our goal is to make the sound quality of your music exceed you expectations, and catch the attention of industry pros.
What's up? I'm Zander, and I'm a versatile artist, songwriter, multi-instrumentalist, and producer that specializes in Pop, R&B, Electronic, and metal/rock music.
Esthetic Vibes
15 years of experience in music industry. Wide range of services are available in-house with our friends around the world. Music production, Mixing, mastering, co-writing with famous names.
David Miller
Melbourne, Australia, based mixer/producer/engineer.
Imani B {The Producer}
Sound engineer specialising in RnB/ Hip/Hop, Bashment & Pop. If you want your songs sounding radio worthy. Hit me up‼
Oscar Neidhardt
Paris-born, Munich-raised and London-based, Oscar Neidhardt is a music producer, songwriter, and multi-instrumentalist.
Joshua Heartstone
My job is to ensure every mix is top-notch quality and that every client is 100% satisfied! With a degree from the Berklee College of Music in Mixing and Mastering with Pro Tools, I will work hard to help you achieve the best sound!
Music runs through my blood and that's why I am always happy when making music.
HitHouze, you don't leave this crib without a hit.
Long Keenyo
Without music The life is music
Jazzda Music
Experienced music producer and mixing engineer.
I started 15 years ago on the amazing journey of Producing and Song Writing; working with all types of musicians and songwriters to create a sound so unique and different that people can't stop but vibe to it.
Red Pipe Studios
Red Pipe Studios NYC offers exceptional audio mastering services for internationally & nationally recognized artists and music producers. Our mastering suite is an acoustically designed critical listening room that features the highest quality analog mastering-grade equipment.
Marco Perino
Experienced Musician - Audio Editor - Producer - DJ - Composer - Sound Designer -Song Writer - Lyricist - Author - Book Writer - Trainer - Movie Sound Mixer
Ryder Stuart
I'm a modern musician based out of New York who specializes in all styles of popular music. I played guitar at Carnegie Hall's The Lead Belly Fest alongside the likes of Buddy Guy and written, produced and mixed songs that have been synced in commercials for Neutrogena, Victoria's Secret etc. Signed to 25th st/Raleigh Publishing
2x Grammy nominated songwriter for his latest song "All the way up" Fat Joe, Remy Ma Featuring French Montana and Infared.
World class musician Oren Tsor (worked with Alex Clare & Kutiman) does online string arranging and recording
INTHARA Studio
Won 2 Lao Music Awards - Best song/producer of the year
am African Engineer Based in Tanzania Africa,experienced in live sound for 9 years,Mixed alot of Engineers in my career like sean kingstone, MiMis,P square,Gyptian,Ludacris,Papa wemba,Fally Ipupa and so Many of Gospeal artists like Benjamin Dube,Solly mahlangu,Keke,. worked in media As head of Sound for 3 years. am 34 years old married with two kid
We are both identical twins, but not each others. We work with Think Up Anger to create original trailer music and landed our first TV spot for a summer promo trailer for TNT. We also created music for the first Power Rangers movie trailer released in 2017 featuring Halsey singing "Walk The Line". Many more special projects to be released soon.
Rack Beats
Hardworking producer Let's get it
BlackCity M.G a.k.a Jai-Dig
Hello Our team consist of Male/Female top-line writers and singers, Musicians ranging from Keys to Guitar/bass drums... various styles are covered. Engineers etc. . We have worked with and placed songs on Earth Wind and Fire, T. Mills, Snoop, Neal Pogue several TV placements. Blah blah blah... WE LOVE WHAT WE DO!!
Over 15 years of experience in music production,composing and sound design. 20 years of dj . Release of 3 albums, 2 soundtracks and music for 2 plays and dance show. If u looking for a full heart and profeesional work - i got it :)
Electronic music producer with 9 years of experience.
Michal Olownia
Recording and mixing engineer/music producer located in NY. Experienced with studio and live recording, mixing and mastering. Musician - bass guitar.
Matt Wehrhahn
I am an experienced audio engineer that works in the New Jersey/New York area. I love the collaboration process and specialize in mixing music. My experience has taken me to some of the best studios in NYC and I have worked with some amazing artists.
Doma Schrank
Los Angeles based composer, songwriter, producer, musician.
Jeremy "Backpack" Miller
Producer Jeremy "Backpack" Miller is crossing genres and breaking down barriers. Working with and producing for many Grammy Award Winning Artist/Songwriters, "Backpack" has 10 years of experience to take your sound to next level. I'm here to help craft a sound around you!
Aaron Tosti
Rock, Pop, and Indie style session drummer / engineer. The way the drums are captured defines the style you are going for. I get the drum sounds and take YOU want.
Nathan Bailey
Trained mixing engineer and beat-maker. I make Hip-Hop/Grime beats and and specialise in mixing vocals.
DOMC Mastering
DOMC Mastering is a custom-designed, dedicated mastering suite in Australia, specialising in getting YOUR next audio recording ready for the public. We can handle most audio formats, analogue and digital.
Irik Weisberg
Audio Engineer Owner_Soundynamic Chief Engineer_Galexi Sound
Grandma's Studio
My name is Bryan Brundige and at Grandma's Studio we specialize in the creation and capturing of music. My expertise are in Recording, Music Production, Mixing, and Songwriting. I have had the opportunity to work with many talented artists in the Live and Recording realm: Pete Seeger, James Taylor, B.B. King, Maceo Parker, Soulive, Ravi Coltrane...
Chromaphonic Recordings
Hello I am a professional engineer of over 15 years in the business. I have worked with musicians from Spain, Italy, Australia, and across the country. I worked for many professional recording studios in the past and now own and operate my own studio. I believe that reputation is everything and will do my best to fulfill your audio production needs
Producing and Mixing music for over
Sousa Beats
Young music producer from Berlin, focused in Hip-Hop & Pop.
Tyree McKelton
Music Producer, composer and session musician for hire....
Mass Slaughter Productions
I am Miles Slaughter im from Los Angeles i recently graduated from pinnacle college. I have started a production team with some friends from school called the Kore and my record label is called Mass Slaughter Productions. We have finished our first album and im currently working on other projects for some new artist
Prime Time Sound Studios
Prime Time Sounds located in Mt. Vernon, NY is a 5,000 square foot recording and rehearsal facility with a live showcase room. Our engineers have graduated with degrees in Audio Engineering and the owners Ray Carozza and Tarik Solange have been producers for over 25 years. We have worked with bands, solo artists, voice-over actors and radio ads!
Ramir Hernandez is a New York based music producer and mixing engineer with over 10 years in the field of audio engineering and music production. Ready to deliver nothing but quality and expertise.
Doug Geikie
Platinum selling Recording engineer / Producer
Joe Haederle
What's up ya'll? My name is Joe and I'm an electronic musician, sound designer and Ableton Live wizard.
TonalityTools - Steve Marlowe
TonalityTools Studios, LLC Mixing, Mastering and Studio Engineering Song writing and production. We work with musicians around the world!
upload studio
Upload-studio is a mix and mastering suite located in Montpellier (south of france) run by french soundman & producer bruno "brew" varea (panzer flower,dagoba,hardbanger,mephisto,rinocerose,mattrach, acod, blazing war machine,etc..)
I'm a musician,songwriter,producer, and engineer out of L.A. I've started taking an interest to music at the age of 8 years old, writing songs at 15. I have 10 years of audio engineering experience ..
Andre Ampear
I'm a grammy-nominated, multi platinum platinum audio engineer. As well as a platinum selling record producer. I love creating, and I love working with new people, and look forward to soon working with you as well!
Hi! I've been producing music for around 5 years now and almost an year ago I started to study mixing and mastering. I've produced and can mix and/or master anything from unique hiphop beats to dubstep.
The art of being an artist. The Love of expression in the form of Sound. Waves of emotion. Rhythmic passion. I make visions come true by any means necessary.
I have been doind music editing with many kinds of songs. I provide audio tracks in inter college dance , music competitions etc.
Gabe On Tha Engineer
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Volume 22 of the series Nucleic Acids and Molecular Biology pp 315-337
Understanding Membrane Proteins. How to Design Inhibitors of Transmembrane Protein—Protein Interactions
- J. S. SluskyAffiliated withDepartment of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania
- , H. YinAffiliated withDepartment of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania
- , W. F. DeGradoAffiliated withDepartment of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania
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Recent experiments demonstrated that buried membrane-protein hydrogen-bonding is less energetically favorable than the values that are discussed in section 3.3 of this chapter 1. Double mutant cycle analysis allows for the analysis of the interaction of two particular amino acids to the exclusion of their interaction with the rest of the protein. Such analysis of bacteriarhodopsin showed that amino acids in the correct orientation for hydrogen bonding contribute stabilization energies between −1.7 and +0.4 kcal mol−1 with an average over 8 pairs of −0.6 kcal mol−1. This is approximately the same value as that of a hydrogen bond in a soluble protein, and is consistent with the notion that the core of membrane proteins and soluble proteins are biochemically similar. However, it should be noted that the burial of polar amino acids exerts a stablizing effect on membrane proteins beyond hydrogen bonding as well. Though hydrogen bonds may contribute less to the stability of a membrane protein than previously understood, this does not necessarily argue against the importance of the membrane protein hydrogen bond. The membrane protein's unfolded state is more similar-and therefore closer in energy-to its folded state than the unfolded soluble protein is to its folded state. Therefore, although the energy of the hydrogen bond is the same, the relative contribution of the hydrogen bond to the stability of the fold is greater in membrane proteins.
This same study also showed a disparity between hydrogen bonding at lipid-exposed positions and at positions in the core of the protein. Distances between atoms and the strength of the bond between those atoms are tightly correlated. Analysis of the distance of hydrogen bond donors and acceptors in membrane proteins and in soluble proteins revealed that hydrogen bonding in buried positions of membrane proteins have a similar distance distribution to that of solvent exposed positions on soluble proteins. However, lipid-exposed hydrogen bonds are shorter, and thus likely exert a greater stabilizing effect than buried hydrogen bonds in the membrane. This is consistent with the change in dielectric constant for the two environments.
Protein—protein interactions in the membrane are just beginning to be explored. Recently, significant advances have been made in disrupting protein—protein interactions in the membrane through protein design. These advances have allowed for the manipulation of biological processes in vivo, and have been shown to be useful probes for understanding the features that stabilize protein—protein interaction in the membrane. By bringing together information on how individual amino acids modulate transmembrane structure, what forces are responsible for oligomerization in the membrane, and how to computationally encode those concepts, a method has been established to create and disrupt protein—protein interactions in the membrane. This review aims to describe the necessity and utility of such probes, as well as provide a "how-to manual" for the design of such probes.
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- Title
- Understanding Membrane Proteins. How to Design Inhibitors of Transmembrane Protein—Protein Interactions
- Book Title
- Protein Engineering
- Pages
- pp 315-337
- Copyright
- 2009
- 10.1007/978-3-540-70941-1_12
- Print ISBN
- 978-3-540-70937-4
- Online ISBN
- 978-3-540-70941-1
- Series Title
- Nucleic Acids and Molecular Biology
- Series Volume
- 22
- Series ISSN
- 0933-1891
- Publisher
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- Additional Links
- Topics
- Industry Sectors
- eBook Packages
- Editors
- Caroline Köhrer (2)
- Uttam L. RajBhandary (2)
- Editor Affiliations
- 2. Department of Biology, Massachusetts Institute of Technology
- Authors
- J. S. Slusky (3)
- H. Yin (3)
- W. F. DeGrado (3)
- Author Affiliations
- 3. Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Hewlett-Packard Offers $470K to Forward Thinking Colleges in Australia
Good news for a few lucky schools in the South Pacific! As Computerworld reports, Hewlett Packard has just announced three colleges as the official winners of their regional Innovation in Education (IIE) grants program.
The grants were created by HP to reward schools that have been bold in promoting and developing technological innovation in regards to teaching style, curriculum, and choice of college degrees offered. As such, the rewards are well-fitting: each school will receive $150K in desktop, laptop, notebook and tablet PCs, as well as printers and other digital goods from HP. In addition, the faculty of the winning schools will be able to take part in workshops teaching on the best and latest theory and practice in integrating technology in the classroom.
So who are the lucky schools? One is Immanuel Lutheran College in Buderim, Queensland; another is Our Lady of Mercy College in Parramatta, New South Wales. The third is St Mary's College in Adelaide, who won for their Robotics division within their engineering degree program, where students are introduced to robotic design and programming. According to Giovanna Iannicelli, St Mary's College's technology coordinator, this grant "will develop the program by allowing students hands-on access to computer resources... the students will have the technology at their fingertips in a classroom while they're doing the programming for the robots - rather than having blocks of programming in a computer lab, away from what they're actually building."
These schools are truly forward thinking institutions, and HP's executives make no qualms about how proud they are to hand over these awards. Says Peter Ekstedt, Director of Global Citizenship at HP Asia-Pacific and Japan: "The successful proposals put forward serve as lighthouse examples of how technology-enabled schools, students and teachers can lead the way in transforming education in this country." Look forward to more awards like this as still more colleges reach out to new technology in the future.
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