text:
La Farola: Heavenly Tapas on the Devil's Mile
Written by: Sophie Taylor
I have often gazed out of the window of the number 30 bus, trundling along Upper Street, people watching like my life depends on it. I've seen arguments, hilarious falls, forlorn match day marches and many, many dogs. One time I even saw someone I knew waiting to cross at Highbury Corner. I watched him for a good six minutes at the lights wondering what he was doing in this neck of the woods and what he was chuckling about to himself – I even went to tap on the window but the bus pulled away and I started thinking about whether the trench coat in the window of Marie Curie would fit instead as we spun round onto St Paul's Road.
What I've seen most of though, is eateries. Upper Street, Islington is buckling under the weight of restaurants, cafes and gastro pubs all vying for attention and fighting for space along 1500 metres of foodie heaven. It's come a long way since being named The Devil's Mile in 1885 thanks to its prostitution, crime and levels of drunkenness. Well, perhaps the latter remains.
One such foodie dream spot is the Spanish restaurant on the corner of Theberton Street: La Farola, whose colossal windows provide perfect people watching fodder. Having often wondered what the tapas might be like here, I jumped at the chance to give it a go and dragged my illustrator friend with me for an evening of wine and calamari. I say dragged, she got there forty minutes early in anticipation.
You'll find the usual tapas suspects lined up on the menu, alongside some curveballs for desert. There's old reliable chorizo, tortillas and ham croquettes, as well as Iberico pork, ham and chorizo amongst two types of manchego on the charcuteria y quesos menu.
While deciding what to order, we shared marinated Cantabrian white anchovies in olive oil (Boquerones) and a plate of cured Serrano ham topped sourdough bread (Montaditos), thinking of our Madrid born mutual friend and the Summer he made us these on the roof of our Peckham flat.
After this and a glass or two of cherry scented Rioja, we decided on Black Tiger Prawns (Gambas al Ajillo) to share and the highly recommended Courgette Flowers. I'm suddenly reminded of my one attempt to be healthy in Barcelona last year which resulted in ordering crispy aubergine: the thinnest slice of vegetable fried within an inch of it's nutrient dense life in batter and glazed with honey. These sticks of cauliflower are not only deep fried, they are then stuffed with goat's cheese and finished with a drizzle of honey. It's beautiful. Oh dear, you gasp, I'm on a diet! Munch munch munch. The generously sized prawns are sautéed with garlic, olive oil and fresh red chili peppers making us wish we'd ordered more.
Whilst my friend started sketching unsuspecting eaters (we love people spying in equal amounts) and various dishes, I stole the last prawn and ordered desert. I of course wanted the traditional churros dish: more fried goodliness if you please. The mini dough sticks came with chocolate sauce & nutmeg infused vanilla custard which I happily polished off in approximately twelve seconds. My other choice was the owner's favourite. He casually confessed to eating one on the regs before cheekily sauntering out of the restaurant and in to the arms of Angel high street. The favoured dish of choice is the deep fried ice cream, which I will regret not ordering til I die. Or go back, whichever comes first. The portion is astoundingly generous and whilst it sounds unfathomable, it works a dream. La Farola's answer to an arctic slice comes with raspberry jus which just about finished my friend off.
Quaffing back the last of the Rioja and snorting into my glass at my friend's lurid tales, I awkwardly catch the eye of a passing bus passenger outside. We lock our gaze and I realise how far I've come. About 3 metres. Not two hours ago I walked from that bus in to this here restaurant and spent the evening through the looking glass at a Spanish mad hatter's tapas party. Now I know what the prawns taste like and no longer need squint through the window to read the menu. And yes, I'll be back for the ice cream ball if it kills me. Which it might if I keep ordering stuff deep fried.
La Farola, 101 Upper Street, Islington, N1 1QN
Original illustrations by Florence Shaw.
Theatre of Choice: Stick and Twisted by Hivemind
Hivemind are coming to the Hen and Chickens Theatre this Summer with a cracker of an innovative show. Three directors try to win over the audience with improvised stories acted out by the rest of the Hivemind cast on the spur of the moment. As each scene ends you decide whether to "stick" and see where the story goes or "twist" and let the next director take over. The director who ends up with the least scenes acted out has to pay a 'terrible forfeit'. Told you it was harsh.
Hidden Culinary Gem: The Lacy Nook
We have been wondering whether or not to share this secret gem with you for a while now. Having walked past Cazenove Road on many a drunken occasion, we'd spotted The Lacy Nook A Board luring us inwards with a siren's call of cocktails and beer garden. But unfortunately we'd get the timing all wrong and they'd rarely be open. "Closed at 4am! How ludicrous?" we'd holler, slurring and swaying up the road. Until now. Opening last year, The Lacy Nook is a collaboration between two friends who turned to Kickstarter to help them achieve this culinary dream . Think small and large plates of fusion Balkan BBQ, salads and carpaccio alongside
Playing Up: New NYT Show, Three
This year, Playing Up have commissioned a new play by Sophie Ellerby (HighTide First Commissions Writer and NYT REP Company 2013), Three, which will be staged at the Arcola Theatre from 20th to 22nd July. The urban and domestic drama, directed by NYT Associate Director Anna Niland follows three sisters who fight to keep track of reality as their world is turned upside down.
Laughable Acts at Backyard Comedy Club
Tonight, on this dull yet sweaty Monday, what you may well need is to show your confectionary based fillings to the ceiling and let it all out with a huge bellowing guffaw about nothing in particular. Let the likes of quick witted Josie Long, surreal twosome Max and Ivan and the downright uproarious Tom Parry help you escape the chocolate lacking reality of 2017.
Fur Dates: Lottie is Looking for Love
Registered charity, All Dogs Matter are a dog rehoming centre based in Archway. They use a mixture of foster homes and kennel spaces to house their dogs, who are each looking to be fostered or adopted. Occasionally we look through their profiles of beautiful singletons looking for love and feature one at random. We interviewed one newly single lady in particular called Lottie. A fun spirited character with smooth hair and a huge grin, Lottie was a right laugh.
Get Involved: Cally Road Jumble Trail
Next Sunday it's the Cally Road Jumble Trail, run by the community. Think a car boot sale but on the street with vintage clothing, accessories, toys, original creations and cakes if you're lucky. The whole of the trail is set up online over at jumbletrail.com where visitors get a colour coded map to explore and discover all the hidden treasures on offer from your neighbourhood.
Top Four 'What the Deuce!' Wimbledon Screening Spots
You've got your socks pulled up but no Cliff Richard in sight. You're all white shorted up with nowhere to go. It's time to find out where your white headbanded self will fit in. Here's our top four Wimbledon screening hang outs to try this Summer.
Midsummer Fizz Masterclass at Yield N16
Until five minutes ago I would've believed Pet Nat was a holistic dog food brand / veterinary business in Wood Green. I'm half right actually*, but in the boozios world it's a fizzy wine. Pétillant Naturel is light and fizzy, usually pretty low on the alcohol scale and rather sweet. Think the opposite of a dry red wine.
World Foods Market, Abney Hall
Abney Public Hall is hosting a market of world food delicacies next weekend, having gathered together the creme de la creme of planet Earth's cuisine. Prepare for a mass fusion of cultures, great food, drink and music just off Stoke Newington Church Street.
Quiz: How Gentrified Are You?
Otherwise known as the shoredification of London, there are four stages of denial when it comes to dealing with the inevitability of gentrification. Are you a dilapidated ol' boozer clinging on to the same threads since 1989, or more of a craft beer-swilling/moustache-bearing pop up type propping up the bar at a cookie dough cafe? Let's find out before your bedroom's transformed in to a pop up belfie gallery.
Poop poop! Supper Club Banquet at Toad Hall
Poop poop! Get your driving gloves on and tweed jackets ready, for Toady has invited us down to Toad Hall for a banquet on the riverbank. Join The Literary Hour for their all new immersive supper club experience this Summer. It's the eighth in their series of book themed events with multi-sensory five course meals featuring additional surprises… Ooh ratty!
Comedians, Rappers, Actors: Open Mic Night in Stokey
Every last Thursday of the month a motley crew of performing acts shuffle off to the skinny little Moustache Bar on Stoke Newington Road for a night of microphone hogging. It's Open Mic night and the stage isn't just available to acoustic guitar yielding crooners. The floor is open for all you comedians, rappers, poets, hell even actors are welcome to come tread the boards at Moustache Bar this Thursday 27th July.
Walking Tour of Stokey's Rebel History
Ah Stokey. You chilled out little rebel of North London. The seemingly easy breezy, laissez-faire attitude that appears to exude from every award winning eatery and baby clothes shop of Church Street is all but an organic hessian veil over it's anarchic and rebellious history. Nonconformists, anti fascists and dissenters built the area as we know it.
Eating North London: Punjabi Supperclub Recipe
Trying our luck, we decided to ask the wonderful Raina and Saira of Joginder Supper Club to give us some unseen insight in to their centuries old Punjabi recipes. Amazingly they agreed to shed some light on one of their most tasty dishes: the Bhoolghobi Tamatar (cauliflower with tomato and potato). Over to the experts...
North London Bike Tour: Tour De North Four
So this July 198 cyclists head over to Germany to start the Tour de France. If you think that is weird, wait till I tell you it started in Yorkshire a few years ago. Anyway after the three days of the Grand Depart the spectacle of the world's biggest sporting event heads back to France and the action really begins.
Glastonbury Comes to North London
Did you take one look at the ticket prices for Glastonbury, vomit in your mouth and close your laptop slowly? Did you get a debilitating case of FOMO scrolling through your friends Glastonbury pics and "oops lost my phone at Radiohead" status updates? Or did you actually go to Glastonbury, witness Jon Snow drop the f bomb and now know that life will never get any better


text:
Website Design
web design
Weight Watchers by Heather Luipold, via Behance
Elegant Seagulls - Web Design
아이디어 더 보기
Web Design / Acolytes by Alexandre Desjardins, via Behance
fc1379d3f47ca600b519304c21cf9672.jpg 1,200×4,409 pixels
Cool Web Design on the Internet, PRA. #webdesign #webdevelopment #website
Starting with the CSS3 techniques, the ordinary squares from web designs layout elements started to be transformed in circles, triangles, hexagons or rhombuses. But, the 2012 bring in our attention a new trend what appear to be the main web design trend of the 2013 year what consist in a more unique
Hexagonal is the ultimate and professional way for you to present your portfolio or the very best starting point for your own corporate website
Incredible web design layout and color palette selected. I really like this homepage - whatever web designer created this would definitely have a job at Isadora Design. #webdesign #book
Masuline, hi-tech design called "Apidura" by Owen Perry
web design 002

subset: commoncrawl


text:
Gaffer tapeSKU : 111001
Free Shipping. Estimate Delivery within 2-3 working days.Standard Shipping, Estimate Delivery within 3-5 working days.
Gaffer Tape is a multi-purpose low tack fabric tape designed for temporary uses such as securing Photographic Backdrops. The Tape has a vinyl style finish but a cloth weave which gives it a great deal of strength and integrity, yet, the tape can be torn by hand to the correct length.
The Low Tack adhesive is grippy enough to allow background papers and fabrics to be attached to walls and ceilings, it can also be used to attach the trailing edge of the background paper to the floor to prevent "curl". The tape can also be used to join background papers and fabrics together.
The term Gaffer comes from the film industry and refers to the person in charge of the Electricals and lighting which is why the Gaffer Tape has its name, being used extensively in the film.Each roll is film wrapped.
There is a vivid collection of fashion muslin backdrops available in uk.
Color: Black/White
We Also Recommend
ADJUSTABLE BACKDROP STAND (10ft x 8ft)
2.6m Tall Studio Light Accessory Aluminium Metal Stand
Photography Backdrop Stable Base Stand (3m Wide x 3m Tall)
Photography Backdrop Stand 6m Wide x 3m Tall (20ft x 9ft)
Photography Backdrop Clips ( Set Of 5 )


text: Kinky amateur slut licked by a dog This page requires Adobe Flash Player Duration: 4:11 Added: 2016-08-27 Tags / Categories: kinky licked amateur slut If you like these videos you'll definitely appreciate the whole content we have collected here. By the way we update our site with new videos and pics so you can always enjoy fresh zoo movies and kinky pics! Wow. This movie features a real Japanese schoolgirl getting fucked hard by a dog. She gets fucked in different postions, one of them being doggystyle from behind. See this Japanese teen orgasm like nothing you have ever seen before! She also sucks it's cock and licks the dogs asshole Azian Zoo Sex - ENTER HERE RIGHT NOW!!! Related Zoo Sex Porn Horse fucking this kinky bitch Kinky MILF fucking an animal Erect nipples licked by a shepherd Young slut drilled by a horse Zoophilic porn with a long-legged slut Moist pussy drilled by a horny slut Big-dicked mare and a hot slut Ginger slut using her doggy for pleasure Kinky bitching sucking hairy dog cock Kinky bestiality porn in HQ This chick is getting licked Amateur zoophilic porn Kissing between a boxer and a slut Horse cock fucking a tanned slut Teen slut getting fucked by a mongrel Petite slut fucked by a dog Amazing slut railed by a pony Kinky doggy getting used Kinky action with a dog Kinky couple fucking animals Moist pussy licked out by a dog Cute naked slut fucking a shepherd Horny horse fucking a black slut Stockinged slut playing with a dog cock Young blondie slut fucking a dog Nice slut fucks animals Forest sex with a kinky 3D beast Kinky dog loves licking pussy Kinky black Doberman owns this slut MILF-y pussy licked by an animal Classy slut fucking her pet Tight slut fucked by a shepherd Big dog cock for a lusty slut Bedroom sex for a naughty slut Horse being serviced by a slut


text:
Gokyo Lake is very famous for trekking to discover the beautiful Lakes, valley and Himalayan vistas. This trek trail known as several names Gokyo Lake trek, Gokyo valley trek and Gokyo Ri trek. Gokyo Lake trekking is unique trekking leads you to the home of the legendary Sherpa people, on the foothill of the highest peak of the world, the Mt. Everest at 8848m. This trekking follows the highly praised trekking route through the Dudh Koshi to its source the Gokyo Lake to the west of the Everest Base Camp. Gokyo valley is one of the excellent and most popular adventurous trekking valleys in Everest (Khumbu) region. Gokyo Lake trekking trail is provides the view of Lakes, glacier valley and Gokyo peak known as Gokyo Ri from where you will gets close view of world's highest Peak Mount Everest (8848m) and other 3 three above 8000 meters Peak including Mt. Cho-Oyo (8153m), Makalu (8475m) and Lhotse (8511m). Similarly, on the trail, also, one can have a terrific view of Thamserku, Amadablam, Khumbila, Kwande, Pumari, Nuptse, Gyachung Kang and more other silvery mountains.
The traditional Sherpa culture and custom intact with Tibetan society is another attraction of this trekking which will be give you happiness and satisfaction on this way of trekking trail. Gokyo valley trekking trail is provides good network of teahouse facilities (Managed by local Sherpa families) for those who wish to staying in teahouse (Lodge camp) during their trekking in Nepal. Gokyo Lake trekking route is less frequented than Everest Base Camp trekking but trekkers given better feedback of viewing Mt. Everest from Gokyo Ri than Everest Base Camp and Kala Pattar. Gokyo valley there is high pass trek route called Cho La Pass for those who have long holiday and plan to make a challenging trip in Everest region but Gokyo lake trail is return same way to Namche Bazaar and continue trek to Lukla instead of heading to Cho la Pass from Gokyo Lake because below program itinerary that we designed for fly in and fly out from Lukla airport.
If you are looking to do the Gokyo Lake Trek? We offer Gokyo Lake Trek for individual trekker with a guide and porter, the price will be bit expensive but you will get better experience without follows with other tourists and walks on your speed. Whatever, we have special dates fixed for group join basis trekking trip for those who have entirely desire to join with other trekkers for Gokyo Lakes trek please check the available dates and book your holiday or If you are coming with friends or family we will offer this trek as private trek (A trek with friends or family) within our group join basis package cost/price and start the trip any dates that suitable to your holiday schedule.
Day 01: Kathmandu flight to Lukla trek to Phakding (2610m)
Day 02: Phakding trek to Namche Bazaar (3440m)
Day 03: Acclimatization day at Namche Bazaar (3440m)
Day 04: Namche Bazaar trek to Dole (4090m)
Day 05: Dole trek to Machhermo (4410m)
Day 06: Machhermo trek to Gokyo (4750m)
Day 07: Day Hike to Gokyo Ri (5357m)
Day 08: Gokyo trek to Dole (4090m)
Day 09: Dole trek to Namche (3440m)
Day 10: Namche Bazaar trek to Lukla (2840m)
Day 11: Lukla flight to Kathmandu (1350m)
Destination: Nepal
Trekking Region: Everest
Trek Start Point: Lukla
Trek End Point: Lukla
Trekking Accommodation: Teahouse (Lodges)
Trekking Grade: Medium
Best Season: March - June / September-November
Max Elevation: 5480m
Duration: 11 Days
Day 01: Kathmandu flight to Lukla trek to Phakding (2610m)
Early morning your trek guide will be meet you at your hotel and transfer you to airport by private vehicle for the Lukla flight. Kathmandu to Lukla you will fly on a twin-engine (tiny) aircraft. The views from the plane are amazing, providing dramatic views of terraced hills and the distant Himalayan giants. After landing in the village of Lukla (2840m) you will meet the rest of your staff/porters that guide will hire them in Lukla for your whole trek. The trail drops steeply for bit then descends to Chheplung (2660m) and Thado Khosi gaon there is suspension bridge that you have to cross after that you see the head of the valley Mt. Kusum Kanguru (6367m). After bridge climbs bit to reach at Ghat (2590m) on banks of the Dudh Koshi River just short visit at monastery then little easy walk then after climb again to reach at Phakding (2610m) Overnight at Teahouse.
Day 02: Phakding trek to Namche Bazaar (3440m)
Today, the trail we cross the Dudh Koshi river and climb gently the valley to Toktak (2760m) and Benkar (2710m) The trail keeps close to the river valley and is lined with beautiful blue pine and rhododendron forest that is very spectacular in the spring months, when the flowers are in bloom and also you will see the beautiful waterfall. We will see the snow-capped peak of Thamserku (6623m) & Khumbi La (5765m) at Benkar. We cross the Dudh Kosi River at Benkar. From here it is only a short walk to Monjo (2840m). Just beyond the Monjo trek enters the Sagarnatha (Everest) national park where you need to check your permits. After checking the permits the trail steep rocky descend to large farm aftermath cross bridge at Dudh Kosi and follow the west banks. Just short distance up the river is Jorsale (2830m). The trail follows the river for a while, then re-crosses the Dudh Koshi along the river bank and after short ups and downs, makes a steep climb near the confluence of the two rivers (Bhote Koshi & Dush Koshi) then little climb and re-crosses bridge at Dudh Koshi after that the trail follows steeply ascent towards the Namche Bazaar(3440m). One hour before arrive Namche Bazaar from where we may see the Mt. Everest (8848m), Lhotse (8516m) and Nuptse (7879m) first time in your life. Namache bazaar is gate way to khambu. Namche is the main trading village in the Khumbu region and holds a busy Saturday market. There is set a meeting place for the Hindu traders from the lowlands and the Tibetan yak caravans that have reached there by crossing the glaciated Nangpa La pass. Overnight at teahouse.
Day 03: Acclimatization day at Namche Bazaar (3440m)
Acclimatization is most important before heading higher. Most off the trekker's acclimatization at Namche on their trek schedule. Today you may excursion either Thame village or viewpoint as your wish but better to consult with your guide regarding the day trip earlier night. If you prefer to Thame it takes approximately 7/8 hours walking both way go and return to Namche. it is popular for visiting Thame monastery but most of the trekker's choose the easy option just to go Viewpoint in the stand point of splendid view of the Himalayas including Mt. Everest (8848), Lhotse (8516m), Lhotse shar (8382m), Nuptse (7879m), peak- 38(7591m), Ama dablam (6856m), Thamserku (6623m), Kangtega (6783m), Kusum kangaru (6367), Cholaste (6335m), Tabuche peak (6495m), Khumbi La (5765m) and Kwangde Ri (6011m) etc. overnight at teahouse.
Day 04: Namche Bazaar trek to Dole (4090m)
Today the trail at first slightly climb up for a while up to the Chor camp at Namche Bazzar then continue easy level walk to kyangjuma 3550m. Along the way from chor camp at Namche bazaar to kyangjuma you may enjoy incredible view of Mt. Everest (8848), Lhotse (8516m), Lhotse shar (8382m), Nuptse (7879m), peak- 38(7591m), Ama dablam (6856m), Thamserku (6623m), Kangtega (6783m), Kusum kangaru (6367), Cholaste (6335m), Tabuche peak (6495m), Khumbi La (5765m) and Kwangde Ri (6011m). From kyangjuma the trail follows for a while easy level walk through Rhododendron forest to sanasa .There is three way directions from where one way right hand side leads to the direct Everest base camp trek and another way up ward left hand side leads to the Gokyo valley trek. From here the trail steep climb up approximately one and half hour to reach at Mongla danda (3978m) where there are a few teahouse and a chorten so you may rest here for a while and enjoy magnificent view of Mt. Ama dablam including numerous mountains. The trail from Mongla danda descends in steep bends trail to Phortse thanga (3680m). From Phortse thanga you will meet two trails one higher route left hand side lead to Gokyo valley trek and lower trail right hand side lead to Phortse village. From after Phortse Thanga the trail climbs steeply through rhododendron and junipers forests then after small part level walks before to reach at Dole (4090m). Overnight at teahouse.
Day 05: Dole trek to Machhermo (4410m)
Today trek from Dole to Machhermo you will climb gradually along the side of the valley, where the small and thorny bushes give way to scrub juniper as the altitude increases. The trail passes many summer settlements, which are used when yaks are taken to these pastures to graze in the summer months. Ahead of you are excellent views of Cho Oyu (8201m) while back down the valley are the peaks of Kantega (6783m) and Thamserku (6623m). You are walking through Lhabarma (4330m), Luza (4340m) and finally reach at Machhermo (4410m) overnight at teahouse
Day 06: Machhermo trek to Gokyo (4750m)
Today trek from Machhermo to Gokyo the trail climbs a ridge for an excellent view both down valley to Kangtega and up towards to Cho-Oyu (8201m). Beyond the ridge, the valley widens as the trail passes through Pangka at 4390m then descends to the river bank before beginning the climb onto the terminal moraine of the Ngozumpa glacier. It is a steep climb up the moraine, switch backing alongside the stream to the first small lake Longponga (4650m) where a family of Brahmin ducks has resided for many years. After first lake the trail now becomes almost level as it follows the valley past a second lake known as Taujung (4710m) and continue trek to Gokyo Lake (4750m). Overnight at Teahouse
Day 07: Day Hike to Gokyo Ri (5357m)
This day early in the morning we have a steep climb up to the top of Gokyo RI (5357m). There are stunning views of the Gokyo valley, the massive Ngozumpa Glacier and an incredible panoramic view of the whole Khumbu mountains range, such giants as Mt. Cho Oyu (8201m) Mt. Everest (8848), Lhotse (8516m), Nuptse (7879m), Makalu (8481m), Cholaste (6335m), Tabuche peak (6495m) and Gychung Kang (7922m). After enjoy the beautiful views at Gokyo Ri then return to Gokyo (4750m) overnight at teahouse.
Day 08: Gokyo trek to Dole (4090m)
Today the trek back to Dole is an easy downhill walk along the Dudh Koshi River that emerges out of the Ngozumpa Glacier. Passing by the second and then the first Gokyo Lakes and continue trek descends to Pangka (4390m). Along the trail you will see beautiful view of Cholaste (6335m) and Tabuche (6495m) peaks rear up on the right of us. The trail descends below Pangka, and across a level terrace on the slope to climb a rib on the far side of the hill side. Upon reaching the Chorten at the edge, we see great views of Thamserku, Cho Oyu, and Kangtega . We slowly walk down to sprawling village of Machhermo. Again, through the charming hamlet of Luza and Lhabarma then finally reach at Dole (4090m). Overnight at Teahouse
Day 09: Dole trek to Namche (3440m)
Today you taking last inspection back to Cho Oyu range, we start steep descent to Phortse Tenga. Our hike today is mostly down hills. The most outstanding feature of the trail today is the abundance of plant and animal vegetation including wildflowers and Rhododendrons. We might spot faunas like mountain goats, musk deers, pheasants, etc. Waterfalls are also today`s attraction. Upon reaching MongLa, a very wonderfully located lovely place perched on the spur of Mt. Khumbila. We take revised look at Tabuche, Ama Dablam, Thamserku, Kangtega, and a distant view of Tengboche. After a bit of long distance walk, we reach an intersection where the steep path up from Sanasa meets our trail. Now, trail to Namche clings to the steep wooded slope beyond Kyangjuma, winding through several bends. Upon coming to Namche army camp hill, we look back to see Mt. Everest (8848), Lhotse (8516m), Lhotse shar (8382m), Nuptse (7879m), peak- 38(7591m), Ama dablam (6856m), Thamserku (6623m), Kangtega (6783m), Kusum kangaru (6367), Cholaste (6335m), Tabuche peak (6495m), Khumbi La (5765m) and Kwangde Ri (6011m). After Enjoying beautiful view from viewpoint then trek down hill to Namche Bazaar (3440m) overnight at teahouse
Day 10: Namche Bazaar trek to Lukla (2840m)
After Namche the trail descend to Larja dobhan (confluence of two rivers) though the pine forests before you reach at Larja Dobhan you may get last opportunity to see Mt. Everest and Lhotse. After cross the bridge at Larja Dobhan the trail descends for while and then walk along the Dudh Koshi River. Re-cross the Dudh Koshi continue level walk to Jorsale. Beyond the Jorsale the trail leads a bit ascend after that re-crosses the suspension bridge then short steep climb to Monjo (2835m). From Monjo the trail leads descends for a while and cross Dudh kosi over the suspension bridge then short easy level walk to Benkar. After Benker the trail follows a bit up and down and level walk along the Dush kosi valley then after re-crossing the suspension bridge you reach at Phakding (2610m). Beyond Phakding the trail follows a short descends continue level walk for a while then short steep climb up passes several Buddhist setups at Ghat village. Aftermath short steep climb up to Thado kosi and a bit descends re-cross the small bridge then climb up a short distance after that finally you re-crosses last long suspension bridge of your trek. The trail after the long suspension bridge follows the up wards route as far as Chablung, then turns off towards Lukla. The broad trail at Chablung leading uphill to the left hand side climbs steadily past a few (bhattis) local inn and houses. From there the trail follows through scrub forest above the school and houses of Chaurikharka village then final climb up of your trek about half and hour reach lukla Tamang tole where a new settlement with houses and Bhattis then short distance walk to approach to Hotel close by Lukla airport. Overnight at teahouse.
Day 11: Lukla flight to Kathmandu (1350m)
In the morning, we take the tiny aircraft to flight from Lukla to Kathmandu which is very interesting scenery flight journey on the earth. After arrival in Kathmandu airport we drive you to hotel.
|Trip Start
|09th Aug. 2017
|19th Aug. 2017
|Book Now
|07th Sep. 2017
|17th Sep. 2017
|Book Now
|24th Sep. 2017
|04th Oct. 2017
|Book Now
|10th Oct. 2017
|20th Oct. 2017
|Book Now
|16th Oct. 2017
|26th Oct. 2017
|Book Now
|27th Oct. 2017
|06th Nov. 2017
|Book Now
|01st Nov. 2017
|11th Nov. 2017
|Book Now
|17th Nov. 2017
|27th Dec. 2017
|Book Now
|03rd Dec. 2017
|13th Dec. 2017
|Book Now
|11th Dec. 2017
|21st Dec. 2017
|Book Now
|02nd March 2018
|12th March 2018
|Book Now
|09th March 2018
|19th March 2018
|Book Now
|17th March 2018
|27th March 2018
|Book Now
|24th March 2018
|03rd April 2018
|Book Now
|04th April 2018
|14th April 2018
|Book Now
|10th April 2018
|20th April 2018
|Book Now
|20th April 2018
|30th April 2018
|Book Now
|06th May 2018
|16th May 2018
|Book Now
|22th May 2018
|01st June 2018
|Book Now
|07th June 2018
|17th June 2018
|Book Now
NOTE: Above trip price is Per Person in minimum group size two people and above but if you are solo traveler better to ask with us somebody booked yet or not for your desire date because if not booked yet, you need to pay some additional cost than above price to arrange your trip as a private incase we unable to collect the people to join with you. Above fixed departure dates are published to collect people for the group join trip. If departure dates are not appropriate for you or looking to make your own private trip? No worry, we will happily start the trip on your suitable dates as a private or group trip on request.
If above trip itinerary that doesn't suit to your holiday schedule or you wish to modify the itinerary or combines with any travel plans, then please let us know and we'll be happy to create a tailor made itinerary, designed and departure the trip any date that suitable to your holiday schedule especially for you. Please click here for tailor made trip form.


text:
Watch how to make this recipe.
Preheat the oven to 425 degrees F.
Place the puffed pastry rectangles onto a baking pan that's been sprayed with nonstick spray or lined with parchment paper. Add the sugar, salt and lemon juice to the apples. Stir to combine. Allow to sit for a few minutes.
Arrange the apple slices on the pastry rectangles in a straight line, overlapping as you go. Bake until the pastry is puffed and golden brown, about 20 minutes.
Remove from the pan immediately and place on a serving platter. Serve with caramel sauce and chopped pecans.
Recipe courtesy of Ree Drummond
Feed a crowd this summer with easy, delicious recipes like these party sliders.
Get over 70,000 FN recipes on all your mobile devices.
Ask our bot for recipes, meal ideas and daily food trivia.


text:
Woodland Hills Golf Course is a
Public golf course located in
Nacogdoches, Texas. The
Woodland Hills Golf Course golf course
was built in 1971, and provides several facilities including
range, rental clubs, rental carts, rental club, In-House professionals, and more. Here you will find more detailed information including features and facilities available on the
Woodland Hills Golf Course golf course.
August 05, 2017 at 12:00 AMNacogdoches County Expo Center
View Details
August 23, 2017 at 07:30 PMAngelina College
View Details
August 30, 2017 at 07:00 PMNacogdoches County Expo Center
View Details
August 29, 2017 at 07:00 PMGeorge H Henderson Expo Center
View Details


text:
Yesterday I didn't even leave the house other than to grocery shop and out for a quick pizza date night with hubby…and I walked nearly 11,000 steps (over 5 miles) according to my FitBit. It was a BUSY day around the house and considering it was 44 pathetic degrees and overcast much of the day,…
Pomegranate Orange Salad + Weekly Menu
Happy New Year! I made it to midnight. Barely, but still. How about yourself? Historically, New Years Eve is a letdown for me. All the hype of the night with never anything definite on the agenda. It's usually us, the couch, and Ryan Seacrest…with my head hitting the pillow before the ball actually drops. Last…
Sweet Potato and Sausage Strata + Weekly Menu
I've been blogging for 6 ½ years. You guys, that's insane. Mr. Prevention just can't believe it. Since, ya know, he thought my blogging "phase" would last a month, or two. Maybe 3. I wonder if he ever get sick of being wrong… Blogging is just such a part of me and my routine, it'd…
6th Annual Chili Contest: Entry #7 – Manly Meaty Chili + Weekly Menu
It's starting to feel like the holidays and winter around #puremichigan. Our tree is up, our stockings are hung. Packages are arriving on a daily basis because Cyber Monday has already come and gone. I'm finalizing my holiday baking list because I risk being shunned by my father-in-law. There will be buckeyes and peanut clusters….
6th Annual Chili Contest: Entry #6 – Crock Pot Jalapeno Popper White Chicken Chili
Friday evening, there was this weird buzzing/humming noise coming from SOMEWHERE in our kitchen. Mr. Prevention was tearing every appliance – large and small – out of the socket, trying to figure out where the noise was coming from. After shutting off power to the entire house (I love setting the time on every clock! Not!), the…
- « Previous Page
- 1
- 2
- 3
- 4
- 5
- …
- 17
- Next Page »


text:
Asked to list his favorite among the architects who have tried their hands at designing automobiles, William J. Mitchell mentions not Walter Gropius or Le Corbusier or Frank Lloyd Wright but Buckminster Fuller, whose Dymaxion car, a zeppelin-shaped three wheeler, created a sensation in 1933.
"He was an engineer as well as an architect, of course," said Dr. Mitchell, a professor of architecture at M.I.T. He also said Fuller was a genius at capturing public attention.
Shown at the Century of Progress fair in Chicago in 1933, the Dymaxion managed to get into a fatal accident. "It was a failure," Dr. Mitchell said. "But it was full of good ideas."
Le Corbusier dreamed up a basic car of wood in the 1920's called Voiture Minimum, or the minimum car. He also looked to automaking as inspiration for house building.
Some architects even foresaw the concept of networking cars so they could communicate with each other. Frank Lloyd Wright believed that automobiles "should be like a school of fish all working together," reports Ivan Margolius in his book "Automobiles by Architects" (John Wiley & Sons, 2000). In his 1958 book, "The Living City," (Horizon Press, 1958), Wright's drawings showed podlike vehicles with tractor-size rear wheels cooperating with helicopters shaped like flying saucers. PHIL PATTONContinue reading the main story


text:
ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy
- First Online:
- Received:
- Revised:
- Citations
- 720 Downloads
It was the aim of our study to investigate the influence of a selective ET-A receptor antagonist LU 135252 alone and in combination with the ACE-inhibitor, trandolapril on podocyte number and morphology in streptozotocin diabetic rats.
Male Sprague-Dawley rats were injected with 65 mg streptozotocin i.v. and subsequently developed diabetes. Animals were left untreated or received daily either trandolapril (0.3 mg/kg body weight), LU 135252 (50 mg/kg body weight) or a combination of both. After 6 months the experiment was terminated. Glomerular geometry and cellularity were assessed by stereological techniques. Protein expression of TGF-β, ET-1, PDGF-AB, fibronectin, desmin and α-smooth muscle cell actin was investigated by immunohistochemistry.
The mean number of podocytes per glomerulus was lower (86±17 vs. 138±25; p<0.05) and mean podocyte volume was higher in untreated diabetic animals than in non-diabetic controls. Only ACE-i alone and in combination, but not ETA-RB alone prevented loss of podocytes and podocyte hypertrophy. In diabetic rats, increased numbers of PCNA positive and p27kip1 positive cells (mainly podocytes) were reduced by all treatments, but only ACE-i decreased numbers of desmin positive podocytes and tubulointerstitial expression of TGF-β. Albuminuria was increased in untreated diabetes and was prevented only by ACE-i and combination treatment.
Podocyte hypertrophy and degeneration is an early event in diabetic nephropathy leading to a loss of podocytes. Treatment with an ACE-i, but not with an ETA-RB, prevented the development of albuminuria as well as damage and loss of podocytes. The well known anti-proteinuric effect of ACE-i is presumably due at least in part to conservation of podocyte structure. Increased plasma endothelin-1 (ET-1) concentrations and urine excretion of ET-1 have been documented in patients with diabetes and proteinuria [1]. It has been shown that experimental diabetes mellitus increases renal ET-1 gene transcription [2]. To assess the relevance of the ET-system in the pathogenesis of renal structural changes in the model of the STZ-induced diabetic rat we compared the effect of an ETA-receptor specific antagonist with the well known beneficial effect of an ACE-i, especially on podocyte cell number and morphology.
KeywordsPodocyte damage diabetic nephropathy endothelin receptor blocker ACE-inhibitor
- ACE-i
ACE inhibitor
endothelin-A receptor blocker
- Tr
- TGF-β
transforming growth factor-β
platelet derived growth factor
cyclin dependent kinase
- bw
body weight
- bp
blood pressure
proliferating cell nuclear antigen
glomerular basement membrane
The characteristic progressive increase in urinary protein excretion in diabetic nephropathy points to an important role of podocytes in the pathogenesis of diabetic renal diseases. During embryogenesis primordial and immature podocytes freely enter the cell cycle. Mature podocytes then exit cell cycle and have a differentiated phenotype [3]. At this point they are thought to be incapable of replication. Recent reports suggest that podocyte loss is an important factor for the progression of diabetic glomerulosclerosis [4] and that podocyte damage can be prevented by ACE-i [5]. Cell proliferation is strictly controlled at several points of the cell cycle [6], but the role of specific cell cycle proteins in glomerular hypertrophy of diabetic animals has remained unclear. Cyclin dependent kinase (CDK) inhibitors cause cell cycle arrest by inactivating specific CDK complexes required for cell cycle progression. In the current study we focused on p27 KIP1, the major CDK inhibitor causing cell cycle arrest [7] and used desmin staining as one of the earliest signs of non-specific podocyte damage [8].
The antihypertensive and antiproteinuric effect of ACE-i, as well as their protective effect on glomerular morphology, is well established, but very little is known concerning their action on podocytes in diabetic animals. ET-1 has also been claimed to be involved in diabetic nephropathy but its effect on glomerular morphology is unknown [9].
Material and methods
Male Sprague-Dawley rats (Charles River, Germany, mean body weight: 176±19.8 g) were housed at constant room temperature (21°C) and humidity (75%) under a controlled light to dark cycle. The animals had free access to water and standard rat pellets (Altromin 1324, Lage/Lippe, Germany). Experimental diabetes was induced by i.v. injection of 65 mg Streptozotocin (STZ) (Sigma Aldrich, Deisenhofen, Germany). All injected animals developed hyperglycaemia on day 2 after STZ administration. Thereafter, diabetic animals were treated daily with 4.1±1.4 IU/kg body weight (bw) of long-acting human insulin (Insulin Ultratard HM, Aventis, Frankfurt/Main, Germany, 40 I·U/ml). All experiments were conducted in accordance with the "Principles of laboratory animal care".
Experimental protocol
Four days after induction of diabetes the animals were randomly allocated to the following five experimental groups: (i) untreated non-diabetic control animals (n=8); (ii) untreated diabetic animals (n=10); (iii) diabetic animals + ETA-RB (LU 135252:50 mg/kg bw, n=9); (iv) diabetic animals + ACE-i (Trandolapril: 0.3 mg/kg bw, n=12); (v) diabetic animals + ETA-RB + ACE-i (combi: doses as above, n=12).
Medications were administered in the drinking fluid at concentrations calculated to deliver the above mentioned doses. Daily food and water consumption were monitored and the doses adjusted. Body weight, blood glucose and blood pressure (by tail plethysmography) were measured at regular intervals. After 3, 5 and 6 months, animals were kept in metabolic cages for 24-h urine collection. Urinary albumin excretion was measured using a rat specific sandwich ELISA system as described in detail elsewhere [10].
After 6 months the experiment was terminated by retrograde aortic perfusion with glutaraldehyde for morphometric and stereological investigations or with ice cold 0.9% NaCl for immunohistochemistry and in situ hybridisation, respectively [10]. Perfusion pressure was carefully monitored and adequacy of fixation was examined in pilot experiments. The observation period of 6 months was selected because at this time point various studies had shown marked differences in renal structure between STZ-induced diabetic rats and controls by light microscopy [11, 12, 13].
Tissue preparation
The kidneys were taken out, weighed and dissected along a plane perpendicular to the interpolar axis, yielding slices of 1 mm thickness. Ten small pieces of one kidney were selected by area weighted sampling for embedding in Epon-Araldite. Semithin (1 µm) and ultrathin sections (0.08 µm) were prepared and stained with methylene blue/basic fuchsin or lead citrate/uranyl acetate, respectively. The remaining tissue slices were embedded in paraffin; 4 µm sections were prepared and stained with haematoxylin/eosin and Periodic Acid Schiff (PAS). For immunohistological investigations one half of the kidney was fixed in 4% buffered formaldehyde, embedded in paraffin and cut into 2 µm thick sections. For in situ hybridisation, the remaining part of the kidney was snap frozen in liquid nitrogen-cooled isopentane. Paraffin sections were prepared and were incubated with the following antibodies using the avidin biotin method: PCNA (proliferating cell nuclear antigen; α-PCNA monoclonal mouse, Immunotech, Marseille, France), P27KIP1 (α-P27 polyclonal rabbit, Santa Cruz, Calif., USA), TGF-β1 (anti-TGF-β1, rabbit polyclonal IgG, Santa Cruz Biotechnology, Santa Cruz, Calif., USA), α-smooth muscle cell actin (monoclonal mouse, Dako, Glostrup, Denmark) and desmin (α-desmin monoclonal mouse, Capinteria, Calif., USA). Cryostat sections that were 5 µm thick were prepared and the sections were incubated with the following antibodies using the avidin biotin method [10]: fibronectin (α-fibronectin polyclonal rabbit, Sigma-Aldrich, Steinheim, Germany), endothelin (α-ET-1 polyclonal rabbit, Biotrend, Cologne, Germany) and PDGF-AB (platelet derived growth factor; α-PDGF-AB polyclonal goat, Upstate Biotechnology, Waltham, USA). Optimal staining concentration was evaluated testing different dilution series. The following dilutions of antibodies were used: PCNA 1:150 [8], p27KIP1 1:500 [7], desmin 1:50 [14], α-smooth muscle actin 1:200, TGF-β 1:300 [15], ET-1 1:25 [16], fibronectin 1:150 [15] and PDGF 1:50 [15].
To avoid non-specific cross reactions of tissue components with antibody, a biotin-streptavidin detection system (biotin-streptavidin super sensitive; BioGenex, San Ramon, Calif., USA) was selected [10]. Negative controls were carried out by omitting the primary antibody.
Morphological investigations—indices of renal damage (glomerulosclerosis, tubulointerstitial and vascular damage)
The degree of sclerosis within the glomerular tuft as an index of progression was evaluated on Periodic Acid Schiff (PAS) stained paraffin sections, adopting the semiquantitative scoring system [17]. All investigations were carried out twice in a blinded manner, that is, the two observers were unaware of the animals study group. The glomerular score of each animal was derived as the mean of 100 glomeruli using light microscopy at a magnification of × 400. The severity of glomerulosclerosis was expressed on an arbitrary scale from 0 to 4 [17]. The glomerular score for individual glomeruli was: grade 0, normal glomerulus; grade 1, incipient mesangial expansion/thickening of the basement membrane [18], irregular lumina of capillaries; grade 2, mild/moderate segmental hyalinosis/sclerosis involving less than 50% of the glomerular tuft; grade 3, diffuse glomerular hyalinosis/sclerosis involving more than 50% of the tuft; grade 4, diffuse glomerulosclerosis with total tuft obliteration and collapse. The resulting index in each animal was expressed as a mean of all scores obtained.
Tubulointerstitial and vascular damage was assessed on Periodic Acid Schiff (PAS) stained paraffin sections at a magnification of ×100 using a similar scoring system [19]. For determination of the tubulointerstitial damage score, 10 fields per kidney were randomly sampled and the changes (0–4) were graded as follows: grade 0, no change; grade 1, lesions involving less than 25% of the area; grade 2, lesions affecting 25 to 50%; grade 3, lesions involving more than 50% and grade 4 involving (almost) the entire area. Similarly, for the vascular damage score the following scheme was adopted: grade 0: no wall thickening, grade 1: mild wall thickening, grade 2: moderate wall thickening, grade 3: severe wall thickening, grade 4: fibrinoid necrosis of the vascular wall.
Glomerular geometry
Area (AA) and volume density (VV) of the renal cortex and medulla as well as the number of glomeruli per area (NA) were measured using a Zeiss eyepiece (Integrationsplatte II; Zeiss, Oberkochen, Germany) and the point counting method (PP=AA=VV) at a magnification of ×400. The number of glomeruli per area (NA) was then corrected for tissue shrinkage (1.082). Total cortex volume (Vcortex) was derived from kidney mass divided by specific weight of the kidney (1.04 g/cm3) times the volume density of the cortex. Glomerular geometry was analysed as follows: volume density (VV) of glomeruli and tubulointerstitium as well as the area density of the glomerular tuft (AAT) were measured by point counting according to PP=AA=VV [20, 21] at a magnification of ×400 on HE sections. Total area of glomerular tuft (AT) was then calculated as AT=AAT×Acortex. The number of glomeruli per volume (NV) was derived from glomerular area density (NA) and the volume density (VV) of glomerular using the formula: NV=k/β×NA1.5/VV0.5 with k=1.1 (size distribution coefficient) and β=1.382 (shape coefficient for spheres). The total number of glomeruli was calculated from the total volume of the renal cortex and the number of glomeruli per cortex volume: Nglom=NV×VCortex. The mean glomerular tuft volume was calculated according to v=β/k×AT1.5 with β=1.382 and k=1.1 [22, 23].
Analysis of glomerular cell number and volume
In five semithin sections per animal glomerular cell number and volume were analysed using the point counting method and a 100 point eyepiece (Integrationsplatte II, Zeiss, Oberkochen Germany) at a magnification of ×1000 (oil immersion) [22, 23]. Briefly, glomerular cell number (podocytes, mesangial and endothelial cells) was calculated in at least 30 glomeruli per animal from cell density per volume (Ncv) and volume density of the respective cell type (Vcv) according to the equation: Ncv=k/β×NcA1.5/Vcv0.5 with β for podocytes =1.5 and for mesangial and endothelial cells =1.4 and k=1 [22, 23]. The respective cell volume was calculated with Vc=Vcv×Vglom.
Analysis of tubulointerstitial volume
Area (Aint) and volume density (Vint) of the tubulointerstitium were measured using a Zeiss eyepiece (Integrationsplatte II; Zeiss, Oberkochen, Germany) and the point counting method (PP=AA=VV) at a magnification of ×25: Vint=VN×Vvint [24].
Immunohistological investigations
Immunohistochemical staining for PCNA and p27KIP1 was evaluated using light microscopy at a magnification of ×400. In 50 glomeruli per kidney the number of PCNA and p27KIP1 positive cells per glomerulus as well as per glomerular and per tubulointerstitial area were counted. Immunohistological stains using antibodies against TGF-β1, ET-1, fibronectin, α-smooth muscle actin and PDGF were analysed by two investigators blinded with respect to the animal group using the following semiquantitative scoring system (0–4): score 0: no expression, score 1: weak expression, score 2: moderate expression, score 3: strong expression, score 4: extremely strong expression. In a number of animals (n =5) per group desmin positivity of podocytes and actin positivity of mesangial cells were investigated as markers of cell degeneration and activation, respectively. For analysis of desmin immunohistochemistry the capillary tuft was divided into four quarters and the following scoring system was used: score 0: no expression, score 1: desmin positive cells in one quarter, score 2: desmin positive cells in two quarters, score 3: desmin positive cells in three quarters and score 4: desmin positive cells all over the capillary tuft. The damage score was then calculated as: [(0-score 0)+ score 1+ score 2+ score 3+ score 4):5]+15.
In situ hybridisation
Non radioactive in situ hybridisation using ET-1 sense and antisense probes was carried out in five animals per group [25, 26]. Briefly, cryostat sections (10 µm) were fixed with 3% paraformaldehyde/phosphate buffered saline (PBS, 5 min, 4°C, pH 7.0). Subsequently, the sections were dehydrated, air-dried, and stored at −20°C.
Probe preparation and labelling
A 340 bp cDNA fragment of the ET-1 cDNA was obtained from a PCR product using rat ET-1 specific primers after reverse transcriptation of rat kidney total RNA [27]. The segment encoding positions 222 to 561 of the rat ET-1 gene was inserted into the pGEM-T vector system (Promega Biotech., Madison, USA). For preparation of the antisense RNA probe, the plasmid was linearised with Spe I and transcribed using T7 Bacteriophage RNA polymerase. Linearization of the plasmid with Nco I and transcription with SP6 RNA Polymerase generated the sense RNA probe. Digoxigenin-labelled RNA probes were synthesized using a DIG RNA labelling mix (Boehringer Mannheim, Mannheim, Germany). The sections were hybridised with 4 ng of labelled probe in buffer in a moist chamber. Hybridisation of the probe with native mRNA was allowed for 18 h at 50°C. Afterwards, several post hybridisation steps were carried out. After post hybridisation washes, the sections were equilibrated in buffer I [25]. Non-specific background staining was blocked by incubation for 1 h with 0.5% blocking reagent/buffer I (Boehringer Mannheim, Germany) [25]. The hybridisation products were visualised by enzyme-linked immunoassay using alkaline phosphatase-conjugated sheep anti-digoxigenin-Fab fragments (750 U/ml, Boehringer Mannheim, Germany,). Following incubation at 4°C overnight, unbound conjugate was removed by two washes in buffer I followed by equilibration of the sections in buffer II [25]. Nitro-blue tetra-zolium (NBT) and 5-bromo-4-chloro-3-indolyl phosphate (BCIP) served as chromogens. Negative controls included hybridisation with the sense RNA probe, incubation without probe for detection of unspecific binding of the primary antibody and omission of both probe and primary antibody. Staining intensity was analysed using the previously described semiquantitative scoring system (scores 0–4) [28].
Data are given as means ± SD. After testing for normality, Kruskal-Wallis test or one-way ANOVA, respectively, were chosen for analysis of variance, followed by Duncan's multiple-range test to calculate whether the differences between the groups were significant. The results were considered significant when the p value was less than 0.05.
Changes of desmin positivity are given as means ± range and the differences were analysed using Mann Whitney U test (p<0.05).
Animal data
Animal data (after termination of the experiment)
non-diabetic control [n=8]
untreated diabetes [n=10]
diabetes + ETA-RB [n=9]
diabetes + ACE-i [n=12]
diabetes + combi [n=12]
body weight [g]
kidney weight [g]
blood glucose [mg/dl]
HbA1c [%]
daily food consumption [g]
systolic bp [mmHg]
albuminuria [mg/24 h]
After 6 months, systolic blood pressure (bp) was higher in untreated diabetic animals compared to non-diabetic controls and was lower in ACE-i and ACE-i + ETA-RB treated animals. In diabetic animals treated with the ETA-RB, bp ranged between untreated and ACE-i treated diabetic rats, but was still lower than in untreated diabetic controls.
Urinary albumin excretion was higher in untreated diabetic animals. Urinary albumin excretion was reduced by ACE-i treatment alone and in combination with ETA-RB, but not with the ETA-RB alone.
Morphological investigations
Indices of renal damage and glomerular geometry
non-diabetic control [n=8]
untreated diabetes [n=10]
diabetes + ETA-RB [n=9]
diabetes + ACE-i [n=12]
diabetes + combi [n=12]
glomerulosclerosis index
tubulointerstitial damage index
vascular damage index
total number of glomeruli per one kidney
46 152±17 094
36 438±5 683
48 848±9 320
40 510±9 594
36 476±2 284
mean glomerular volume [×106 µm3]
tubulointerstitial volume [cm3]
The tubulointerstitial damage index was also higher in untreated diabetic rats compared to non-diabetic controls. It was lower in groups with ACE-i and combination treatment, but not in the ETA-RB treated diabetic rats.
Mean glomerular volume was higher in untreated diabetic animals compared to non-diabetic controls and was lower in all diabetic intervention groups. The total number of glomeruli per kidney was similar in all experimental groups.
Mean tubulointerstitial volume was higher in untreated diabetic rats than in non-diabetic rats. Only ACE-i alone and in combination led to lower values whereas ETA-RB had no influence.
Number and volume of glomerular cells
non-diabetic control [n=8]
untreated diabetes [n=10]
diabetes + ETA-RB [n=9]
diabetes + ACE-i [n=12]
diabetes + combi [n=12]
podocyte number per glomerulus
mean podocyte volume [μm3]
63 099±1015+
72 172±5930*
71 193±9899
62 313±1126+
52 754±1175+
mesangial cell number per glomerulus
mean mesangial cell volume [μm3]
31 336±3123+
42 614±1270*
37 534±3711
29 781±1171+
34 325±4116+
endothelial cell number per glomerulus
Immunohistochemical investigations
Number of PCNA positive glomerular and tubulointerstitial cells as well as number of p27 positive glomerular cells
non-diabetic control [n=8]
untreated diabetes [n=10]
diabetes + ETA-RB [n=9]
diabetes + ACE-i [n=12]
diabetes + combi [n=12]
PCNA positive cells per glomerular profile
PCNA positive cells per mm of tubulointerstitial area
2.32 ±1.16*+
P27 positive cells per glomerular profile
The effect of ACE-i and ETA-RB on protein expression of fibronectin, a major component of the mesangial matrix (Fig. 3B). Fibronectin staining was higher in tubulointerstitial and vascular smooth muscle cells of untreated diabetic rats than in non-diabetic controls; it was less intensive in all treatment groups. In contrast, glomerular fibronectin expression was comparable in all groups.
PDGF (Fig. 3C):The effect of ACE-i and ETA-RB on expression of PDGF protein, an important growth factor for mesangial cells (Fig. 3C). On the protein level PDGF-AB was expressed in mesangial, tubulointerstitial and vascular smooth muscle cells of untreated diabetic animals and the expression was more pronounced than in non-diabetic controls. It was less intense, however, in all treatment groups.
The effect of ACE-i and ETA-RB on expression of TGF-β1 protein is shown in figure 3D. Glomerular and tubulointerstitial TGF-β1 protein expression was higher in untreated diabetic rats than in controls. All treatment groups showed lower glomerular TGF-β1 protein expression, but only ACE-i and combination treatment led to comparable glomerular and tubulointerstitial expression of TGF-β1 as in controls. In contrast, treatment with ETA-RB did not lower tubulointerstitial TGF-β1 protein expression.
By immunohistochemistry, mesangial cells or other glomerular cells were not positive for actin, a marker for mesangial cell activation, in any of the experimental groups (data not shown).
ET-1 mRNA by non radioactive in-situ hybridisation
The importance of podocyte injury for progressive diabetic nephropathy has been documented in human Type 2 diabetic patients: podocyte loss is seen in the early stages of progressive glomerulosclerosis in diabetic Pima Indians [29, 30]. Podocyte loss was also found in Type 1 diabetic patients [31]. In our study, STZ-induced diabetes led to marked activation of renal and specifically of podocyte ET-1 expression and finally to a loss of podocytes. The loss of podocytes could be prevented by ACE-i and subsequently urinary albumin excretion was reduced. In contrast, treatment with ETA-RB was ineffective in this respect. Podocyte damage and an abnormal podocyte phenotype was illustrated by increased staining for desmin as a sign for a switch-over to intermediate filament expression [8, 32, 33]. Treatment with ACE-i, but not with ETA-RB, led to lower glomerular staining for desmin.
Up-regulation of the CDK inhibitors p21 and p27Kip1 was shown in podocytes [34, 35] of diabetic rats. It has been suggested that p27Kip1 stabilizes the cell cycle of these terminally differentiated cells [36]. Increased p27Kip1 expression is cell-protective and reflects a cellular reaction to injury or stress in podocytes [34]. This hypothesis is supported by our observation of increased p27Kip1 expression in parallel with increased expression of PCNA by podocytes of untreated STZ diabetic rats. Interestingly, both ACE-i and ETA-RB lowered p27Kip1 and PCNA expression as well as glomerular hypertrophy, but only ACE-i prevented podocyte hypertrophy and staining for desmin. This observation suggests that ANG II influences pathways independent of p27Kip1 and PCNA.
Based on studies in diabetic BB dp rats, it has been concluded that expression of p27Kip1 is explained, at least in part, by higher TGF-β levels [37]. TGF-β expression was reduced by the ACE-i enalapril [37]. Our study documents that both ACE-i and ETA-RB reduced p27Kip1 and TGF-β expression, but only ACE-i preserves podocyte ultrastructure, providing further evidence that the Ang II and ET-1 operate through partially different pathways.
Progressive podocyte damage in diabetic fafa rats occurs through three potential pathways: (i) damage from hyperlipidaemia, (ii) damage from glomerular infiltration by monocyte/macrophages and (iii) damage resulting from glomerular hypertrophy [33]. In our study, serum cholesterol concentration was not increased in diabetic rats and we failed to find glomerular infiltration by monocyte/macrophages. In contrast, we could document glomerular hypertrophy. In a hypertrophied glomerulus an increased surface of basal membrane has to be covered by an unchanged number of podocytes. This mechanism is thought to cause podocyte injury. The explanation is definitely simplicistic, given the fact that in our study all interventions, both ACE-i and ETA-RB, prevented glomerular hypertrophy, and yet only ACE-i prevented podocyte injury as reflected by staining for desmin. This finding, however, is in agreement with the observation by others [5] that reduction of the number of slit pores in podocyte foot processes of diabetic rats was prevented by ACE-i or AT1-receptor blockers. It is of interest that autoradiographic studies documented a high density of Ang II binding sites in glomeruli [38, 39]. The presence of AT-1-subtype receptors for Ang II is illustrated by studies in podocyte cultures where Ang II depolarised podocytes [40]. Additionally, functional ET-1 receptors had been also found on podocytes [41].
This study in STZ-induced diabetic rats confirms that the earliest lesions are altered podocyte ultrastructure i.e. atypical expression of intermediate filaments of the desmin type. This is associated with increased expression of PCNA, presumably a reaction to cell injury rather than a marker of cell proliferation, because the number of podocytes decreases. Proliferation is presumably prevented by increased expression of p27Kip1. Although podocytes of diabetic animals show increased expression of ET-1, and although podocytes are known to have ET-receptors, blockade of the ET system by ETA-RB failed to prevent the changes in ultrastructure and desmin expression. In contrast, Ang II seems to be causally involved, since ACE-i prevented the change in podocyte ultrastructure as well as expression of desmin PCNA and p27Kip1.
A. Koch and M.L. Groß are recipients of a grant in the Graduiertenkolleg "Nieren- und Kreislaufregulation" of the Deutsche Forschungsgemeinschaft. The study was supported by grants of the Deutsche Forschungsgemeinschaft (SFB 423, project B8) and the DAAD (323-PPP Hungary).
The skilful technical assistance of H. Ziebart, Z. Antoni, H. Derks, G. Gorsberg, D. Lutz, P. Rieger, S. Söllner, M. Weckbach and S. Wessels is gratefully acknowledged. The authors thank U. Reulbach, Dept. of Biostatistics, University of Erlangen-Nürnberg, for statistical advice and H. Derks and U. Burkhardt for the photographs and organizing the layout. The authors thank Dr. R. Truman, BASF Service II, Ludwigshafen, Germany, a native speaker, who corrected the manuscript.


text:
Face Serum
T•LANGHANS Face Serum is the perfect follow up to our Cleansing Face Oil.
Loaded with antioxidant intense oils, not water! Take a look at the ingredients:
Tocopherol: Vitamin E
- Canada - FREE SHIPPING for orders over $100
- Canada - FREE CUSTOMER PICKUP available in Uxbridge, Ontario
- Ships Internationally


text:
About BannerBuzz.com Coupons, Deals and Cash Back
BannerBuzz.com sells over 300 different products including custom banners, signs, table display products, marketing materials throughout the USA. All products have customizable specs.
BannerBuzz.com Coupons, Promo Codes & Cash Back
No BannerBuzz.com coupons or promo codes are available at this time, but you can find other offers below.
Cash Back Terms
Exclusions: Cash Back is not available on the purchase or redemption of gift cards.
Cash Back will be automatically added to your Ebates account within one week.


text:
If you're puffing your way through a pack or more of cigarettes each day, you should be aware that this can be very detrimental to your looks. This is important if you want to look your best all of the time as the chemicals found in each cigarette can result in some completely disgusting symptoms, each of which can be seen by those around you. If you take pride in your appearance, but are struggling to quit this dangerous pastime, here are four of the grossest effects that smoking can have on your body.
Gum Disease
Science has shown that smokers have a higher susceptibility to gum disease, an illness which can cause bleeding, discoloured gums. Basically, this works via the following stages:
- Bacteria build up in the gum area of the mouth
- Infection begins and the body attempts to fight it off
- Affected tissue is slowly destroyed via the immune response
- Bleeding and red gums appear at this time
- In extreme cases, the gums turn black as the tissue dies
- Loss of tissue can also cause teeth to fall out
Smokers are more prone to this simply because the cigarette smoke makes it harder for the body to fight off illness. It limits the flow of oxygen, speeding up the onset and progression of gum disease, eventually putting your good looks at risk.
Early Wrinkling
Cigarettes are also known to speed up the aging process, causing an increase in wrinkles. Nicotine narrows the blood vessels in the skin, depriving it of the oxygen it needs to stay fresh and elastic. If you pride yourself on your youthful appearance, it is time to quit as soon as you can. If you don't stop now, you'll put yourself at risk of aged skin on your face and other parts of the body too. So that you look young for a lot longer, try out the anti-smoking medicine from Prescription 2 Home. They'll give you the edge you need to beat the habit. This will hopefully occur before your skin turns as dry and rough as a parched riverbed in the middle of a drought.
Teeth Stains
Moving back to the mouth, it is a well-known fact that long-term smokers all suffer from yellow teeth. This, again, is something that can be seen which should be enough to deter those who are truly concerned with their appearance. This disgusting staining is caused through a build-up of nicotine and tar on the teeth. Every time you smoke, another layer is added, causing a yellow colouring over time.
In fact, these substances coat the interior of your mouth and lungs as well. Since your teeth are white, it is here that the discolouration is more easily noticed however. If you are already seeing a yellow colour on your enamel, imagine what the interior of your lungs looks like! This should be gross enough to cause you to quit as soon as you can.
Cigarette Stench
One last unappealing effect of smoking is that you'll stink. The aroma of cigarette smoke lingers for quite a while and, although you may not notice it, any non-smokers around you will immediately reel back because of the stench. No matter how good looking you are, walking around in a cloud of fumes all day won't enamour yourself to those around you. This will also apply to how your breath smells. For example if you have a partner, they may describe your breath like kissing an ashtray. Again, this isn't the most attractive feature to have and should give you a good reason to stop the habit as quickly as possible.
About the Author:
Prescription 2 Home works closely with Pharmacy2U in providing a convenient and safe method of obtaining prescription medicines from a doctor in the UK.
Latest posts by Matthew (see all)
- Genetic History and Caring for Your Beauty - May 9, 2013
- Four Gross Effects of Smoking on Your Physical Health - May 7, 2013
- How Can Exercising Contribute to a Healthy Skin - May 3, 2013


text:
Encounter for any Solitary Participant within WoW
Wow is definitely an video game, that company a person achat wow po take in order to perform together with your partners within the daring as well as aggregation relaxed to accomplish missions as well as aswell operate dungeons. However, many gamers might take really absolutely no friend or even these people take in order to perform forgotten amongst individuals. Whether they goal this or even not really, these people should have in order to taste the actual daring to game.
When you purchase the things which are beheld because to become a large amount of helping as well as accounts among the lots of precious metal, a person take in order to purchase away greatest locations planting. You are able to purchase the actual verification in certain Wow associated discussion boards or even precious metal within amazing instructions, or even you are able to request the actual friend inside your guild. Using the responsibility objectives, real add-ons, as well as suitable techniques, During my evaluation you are able to achieve lots of amazing precious metal rapidly.
There are some ideas a person cost in order to acheter wow after should you trigger harvesting. At first just about all, We acerb acclaim a person to utilize a suitable add-on in order to abetment a person. There are numerous purchase as well as farming add-ons that within Wow, Obtaining a unintentional novice company that you simply take wealth of your time to accomplish missions as well as build up supplies. It's obtainable to market the actual abstracts concerning the discount home as well as achieve the revenue. Or else, you might entry a few ballsy points whilst questing, don't accouter all of them regarding promote all of them about the discount organization.


text:
Hotel Bologna, Verona
- Free buffet breakfast and free WiFi
Main amenities
- 32 guestrooms
- Restaurant
- Valet parking
- Childcare
- 24-hour front desk
- Air conditioning
- Computer station
- Front desk safe
- Multilingual staff
- Luggage storage
- Bike rental
- Free buffet breakfast and free WiFi
What's around
- In Citta Antica
- Arena di Verona (0.2 mi / 0.2 km)
- Piazza delle Erbe (0.3 mi / 0.5 km)
- Piazza dei Signori (0.4 mi / 0.6 km)
- Castelvecchio (0.4 mi / 0.6 km)
- Juliet's House (0.4 mi / 0.6 km)
Hotel Bologna, Verona
Hotel Info: 866-539-8117from $123
- Junior Suite
- Deluxe Double Room
- Standard Double Room Single Use
- Triple Room
- Single Room
- Suite with Terrace
- Suite
- Standard Double Room
- Standard Single Room
- Small Double Room
More great choices
At a glance
Key facts
Hotel size
- This hotel has 32 rooms
- This hotel is arranged over 4 floors
- Check-in time 2 PM-midnight
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Children (3 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Babysitting/childcare *
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Valet parking *
Nearby Three Star Verona hotels
In the hotel
- Free buffet breakfast daily
- Restaurant
- Room service (during limited hours)
- Bicycle rentals on site
- Computer station
- 24-hour front desk
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 1
- Elevator/lift
- Safe-deposit box at front desk
In the room
- Air conditioning
- Minibar
- Iron/ironing board (on request)
- Down comforter
- Private bathroom
- Shower only
- Bidet
- Free toiletries
- Hair dryer
- Flat-screen TV
- Satellite TV channels
- Desk
- Free WiFi
- In-room safe
Top Verona hotels
Recently reviewed hotels in Verona
- Hotel del PortoFrom
"Check in might be hard because the hotel does not have on the premises parking but, once you find it they give you a key card for a garage nearby with a golf cart assist to bring…"Jul 19, 2017
- Hotel MilanoFrom
"The perfect relaxing getaway! Balcony is definitely worth the extra money. Pool is clean and well maintained. Pool chairs could be upgraded but still do the trick (ran into two…"Jul 17, 2017
- Best Western Hotel FirenzeFrom
"An ideal stop for a short break. Close to Arena,sightseeing And shops with car parking availablr"Jul 16, 2017
- Le Ali del FrassinoFrom
"This stay was unexpected, last minute and divine. We were so pleased. The grounds and hotel were stunning. We didn't want to leave. We will return for sure."Jul 15, 2017
Nearby hotels
Also popular with travelers from the USA
Special features
DiningRistorante Rubiani - Onsite restaurant.
Hotel Bologna, Verona's small print
Also known as
- Bologna Verona
- Hotel Bologna Verona
- Bologna Hotel Verona
All guests, including children, must be present at check-in and show their government-issued photo ID card or passport.
Cash transactions at this property cannot exceed EUR 2999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation.
Parking height restrictions apply.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 1.50 per person, per night, up to 5 nights. This tax does not apply to children under 14 years of age.
Optional extras
Valet parking costs EUR 22 per day
Cribs/Infant beds are available for EUR 20 per night
Babysitting/childcare is available for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


text:
Added: Wednesday, September 30, 2009
Latina Cardina Intense DP Fucking
Cardina is such a stunner! Here we have hot scene where this pretty Latina does a little striptease in front of the camera before giving these guys equal turns in pleasuring their meat by sucking them off and then took them into her pussy and tight ass.
Latin Sex Lovers Video Galleries
More Video Galleries
Amateur Latina couple fuckingViews: 2,369
18 year old LatinaViews: 1,641
18 year old latinaViews: 1,144
Schoolgirl fuckedViews: 2,616
Latina homemade sexViews: 1,858
Hot big ass LatinaViews: 1,633
Latina tight pussyViews: 1,329
Busty sex tapeViews: 1,424
Latina outdoor sexViews: 2,755
Latina girlfriend sexViews: 1,642
Homemade couple fuckingViews: 1,726
Big tits LatinaViews: 1,554
Latina homemade sexViews: 1,229
Hot Latina GFViews: 1,953
Latina homemadeViews: 1,478


text:
"Great technology, great products, great people."
- Work/Life Balance
- Culture & Values
- Career Opportunities
- Comp & Benefits
- Senior Management
I worked at Acquire Media full-time
If you are a 'newshound', there is no better place to work connecting those who write the news with those who need the news. The technology developers are outstanding and they take great pride in their work.
The company contends with some very large, powerful competitors; it takes a great deal of effort to constantly take them on.
Small company, family feel. The open door policy allowed exposure to everyone from the office manager to the CEO and communication was encouraged. Titles were not thrown around and typical corporate egos were not present.
Great innovation but lack of execution which in turn proved difficult to increase revenue. Communication was also challenging when new products were scheduled to launch or updates to existing products were released.
Advice to Management
Great people to work with and continue to appreciate your peers and employees. The enthusiasm and well-intended promises are appreciated, but need to come through when push comes to shove.
I worked at Acquire Media full-time (More than 3 years)
Good, hardworking, smart people
Things can fall through the cracks because of changing priorities


text:
A healthy diet should contain plenty of high-nutrient foods: foods that give our bodies good health and reduce our risk of many diseases and conditions. Those foods are fruits and vegetables, whole grains, fish, poultry, beans (legumes), nuts and seeds, and lots of water.
Beans (legumes) are a valuable source of many life-enhancing nutrients. Luckily, there are dozens of kinds to choose from including: garbanzo beans, kidney beans, black beans, pinto beans, lima beans, great northern beans, red beans, soy beans and many others.
No matter what kind of bean you choose, it is an excellent source of protein, especially when you combine it with whole grains. Beans and whole grains together provide a wide range of amino acids that are essential to your body. (A good example would be beans and rice. )
Since beans are a source of protein, they can be substituted for meat, important for those who are trying to reduce their intake of meat. Your body must have protein in order to function properly.
Beans are also an excellent source of both types of fiber, soluble and insoluble. Fiber acts like a sponge in the body's digestive tract, absorbing substances containing sugars, fats, carbohydrates, and the calories associated with them.
*FIBER REDUCES HIGH CHOLESTEROL. A diet rich in soluble fiber lowers blood levels of harmful cholesterol without lowering the levels of good cholesterol. The gel that is formed from soluble fiber picks up the cholesterol as it passes through the intestines and carries it out of the body.
*FIBER KEEPS BLOOD SUGAR LEVELS STEADY. Soluble fiber slows the absorption of sugar from the intestines. This steadies the blood sugar level and decreases the ups and downs of insulin secretion. By keeping insulin levels low and stable, the body stores less fat, a boost for anyone trying to lose weight.
*FIBER REDUCES THE RISK OF CERTAIN TYPES OF CANCER. The incidence of colon cancer is significantly lower in people who eat lots of high-fiber food. Fiber binds carcinogens (toxins that can transform normal cells into cancerous ones) and moves them through the bowels quickly, decreasing their potential to do harm. It also binds estrogen, reducing the risk of breast cancer.
*FIBER INCREASES YOUR ENERGY LEVEL. Like protein, fiber slows down the digestion process in your body, guaranteeing a balanced energy level throughout the day.
Beans provide a valuable source of nutrients that our bodies need in order to function at optimum level including calcium and magnesium. These two nutrients build strong bones, reducing the risk of osteoporosis. They also maintain healthy muscle tone and combat fatigue.
When shopping for beans, there are numerous choices in your local supermarket. You can buy fresh, frozen, or canned. There are some beans available with low or no added salt. Beans are very versatile and can be added to soups, salads, casseroles, and many other dishes.
In the health foods section of your grocery, you can find ethnic dishes such as Indian and Mexican foods, both containing many bean choices. You can also find canned beans grown without pesticides or herbicides.
If you suffer from excess gas when you eat beans, you can take digestive enzymes or eat beans in small quantities. The easiest beans to digest are green beans, lima beans and tofu (if you can eat soy). Once your system gets accustomed to beans, you can add black beans, kidney beans, and garbanzo beans and others.
Make sure you drink plenty of water every day as water helps to push the fiber through your digestive system promoting healthy bowel movements. Water also speeds up metabolism and flushes toxins out of the body.
As you can see, beans provide excellent nutrient value for your body. Try to include them in your diet every day for maximum health benefits.
Chris Chenoweth, author of the DO-IT-YOURSELF HOME, HEALTH & MONEY GUIDE, writes articles pertaining to diet, exercise, health, and business.


text:
I had bought 3 days - 2 night package which included 1 day trip 7 islands on ferry and 4 meals (2 Breakfast, 1 lunch and 1 seafood buffet dinner). When getting there, i was informed that ferry trip was cancelled since the ferry was not working and we need to go by speed boat which is too bumpy for my pregnant wife. Finally, after half an hour negotiation, I got on ferry trip but only 4 islands trip. The room is very terrible with broken shower. The seafood buffet dinner was not as advertised. It's only one local fried fish (maybe Sadine) each with soup and rice. My comment is not to buy any package or stay over night with this hotel.
- Official Description (provided by the hotel):
- Set against mountain landscapes, Phupranang Resort and Spa is only a few minutes' drive from Ao Nang Beach. It has beautiful gardens, a spa, swimming pool and offers free internet.Rooms at Krabi Phupranang Resort and Spa have private balconies that offer views of the mountain. They are air-conditioned and are equipped with bathroom facilities, minibar and cable TV.The spa at Phupranang Resort offers relaxing treatments and massages. It provides Thai massages, foot reflexology, hair beading and manicure options.The resort's other facilities include a semi open-air restaurant, a garden and pool where guests can relax. Many activities such as fishing, canoeing and dining can be enjoyed at the hotel.Services provided at Phupranang Resort include laundry and free shuttle service to Ao Nang beach. Alterntatively, car rentals are available at the hotel. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with TripOnline SA and Cancelon so you can book your Phupranang Resort and Spa reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Phupranang Hotel Krabi Town
- Phupranang Resort And Spa Krabi, Thailand


text:
A Kind of Murder
In 1960s New York, Walter Stackhouse is a successful architect married to the beautiful Clara who leads a seemingly perfect…Watch & Download Free ⇒
In 1960s New York, Walter Stackhouse is a successful architect married to the beautiful Clara who leads a seemingly perfect…Watch & Download Free ⇒
Verona and Burt have moved to Colorado to be close to Burt's parents but, with Veronica expecting their first child,…Watch & Download Free ⇒
Larry Flynt is the hedonistically obnoxious, but indomitable, publisher of Hustler magazine. The film recounts his struggle to make an…Watch & Download Free ⇒
Skeeter Bronson is a down-on-his-luck guy who's always telling bedtime stories to his niece and nephew. But his life is…Watch & Download Free ⇒
When the rumored whereabouts of Osama bin Laden are revealed, the CIA readies a team of seasoned U.S. Navy SEALs…Watch & Download Free ⇒
Neighborhood boy Todd Bowden discovers that an old man living on his block named Arthur Denker is nazi war criminal.…Watch & Download Free ⇒
Haru, a schoolgirl bored by her ordinary routine, saves the life of an unusual cat and suddenly her world is…Watch & Download Free ⇒
Los Angeles private-eye Philip Marlowe is trying to locate the brother of his new client, a woman named Orfamay Quest.…Watch & Download Free ⇒
Misery is brought to a small group of Sho in the Kalahari desert in the form of a cola bottle.…Watch & Download Free ⇒
We do not host and upload any videos. All the free movies on this website are hosted on the third-party sites and uploaded by other people. We are not responsible for any content that hosted on the third-party sites. If you have any legal issues please contact appropriate video owners / hosters.


text:
PB Teen - Dry Erase Calendar Decal #organized #creative #bedroom
Calendar Horizontal Family Planner Wall Calendar by BlissNotions
Learn how to make your own dry erase DIY calendar with this step by step tutorial. It's fun and simple to make and will make you so much more organized!
Framed Furniture Dry Erase Perpetual Calendar and Bulletin Board with Mail Pocket Organizer Storage Shelf and Keyhooks
Make your own dry erase calendar with a glass picture frame and black adhesive vinyl!
Don't actually like this a lot. I would say this is the "too frou frou" version of what I am thinking.
DIY - fazê-lo sozinho em Stylowi.pl
DIY Dry Erase Calendar ... get a cheap frame from the thrift store and print off a calendar. Less expensive and WAY cuter than the ones from the store.
Hello! Can you believe we are only 3 days away from 2016! That means it's new calendar and diary time! yay! I found this DIY for a ...


text:
from 13,8 USD – Hostel
from 13,5 USD – Hostel
from 12,7 USD – Hostel
from 13,8 USD – Guest accommodation
from 23,0 USD – Guest accommodation
from 25,9 USD – Guest accommodation
from 67,2 USD – Apartment
0.18 km
Alhamar , 46-48 18004, Granada
0.19 km
Pedro Antonio de Alarcón, 10 18005, Granada
0.24 km
Nueva de La Virgen 42, planta 1, Clavel 18005, Granada
0.24 km
Nueva de la Virgen, 40 18005, Granada
* Wszystkie odległości są mierzone w linie prostej, od Twojego punktu do celu.
All bookings are confirmed instantly. No waiting, no email exchanges, no confusion.
Just 5 minutes' walk from the city centre, Hostel Dolce Vita offers free linen, free Wi-Fi and free coffee and tea 24 hours a day. The train station is 3 km away.
All air-conditioned rooms at Hostel Dolce Vita feature parquet flooring and a simple décor inspired by cinema. They are equipped with individual lockers large enough to fit a suitcase. Some rooms have a balcony.
The hostel provides computers with free internet access, and a laundry room for guests' use. The property serves breakfast in the morning and guests have access to a shared kitchen.
The hostel can organize a wide range of activities, including guided visits in and around Granada, bicycle tours or entrance to flamenco shows.
There is a bus stop 5 minutes' walk away, in Puerta Real. There is a wheelchair ramp and bridge plate at the hostel entrance.
Rooms: 6
Please let Hostel Doce Vita know your expected arrival time in advance. You can use the Special Requests box when booking or contact the property.
Bed linen is provided and towels can be rented on site.
Please note that late check-in carries a EUR 5 surcharge.
Shared Bathroom, Shared Toilet, Shower
Air conditioning, Heating, Hardwood/Parquet floors
Linen, Towels
This dorm room features parquet flooring, air conditioning and heating.
Shower, Shared Toilet, Shared Bathroom
Hardwood/Parquet floors, Heating, Air conditioning
Linen, Towels
This dorm room features parquet flooring, air conditioning and heating.
Toilet, Bathroom, Shower
Air conditioning, Hardwood/Parquet floors, Heating
Towels, Linen
This single room has air conditioning.
Shared Bathroom, Shared Toilet, Shower
Hardwood/Parquet floors, Air conditioning, Heating
Linen, Towels
Shared Bathroom, Shared Toilet
Fan, Hardwood/Parquet floors, Heating, Wardrobe/Closet
Linen, Towels
This room is located in a small bungalow and it comes with heating and fans. It has access to all the shared facilities including bathrooms.
After booking, all of the hotel's details, including telephone and email address, are provided in the online booking confirmation, confirmation email.
BBQ facilities, Bar,
Terrace, Games room,
Non-smoking rooms, Air conditioning, Designated smoking area, Heating, Facilities for disabled guests,
Tour desk, Luggage storage, Safety deposit box, Ticket service,
Cycling, Hiking,
Free WiFi! WiFi is available in all areas and is free of charge.
No parking available.
From 14:00 Until 22:00 hours
From 08:00 Until 11:00 hours
All children are welcome.
Children's cots/cribs are not available.
There is no capacity for extra beds in the room.
Pets are not allowed.
Our hotel reviews will help you find the best deal in the right location.
ihr24.com offers the choice of over 600,000 hotels in more than 200 countries.
Sign up for your free My ihr24.com account
Website in English and 17 other languages


text:
I'm a 26 year old working professional. I'll be moving down from Brisbane to work within the Rugby digital media field. I'm looking for a share house/room preferably around the Paddington, Surry Hills & Waterloo areas. I'm a tidy, easy going roommate who enjoys being outdoors on weekends and chilling out on weekdays. I'm always up for a chat but at the same time can respect ones personal space. Please message through if you're interested in teaming up.
Hey I'm from Switzerland and am 20 years old. I speak fluently english and french. I recently got the Working Holiday Visa so I'll be living in Sydney from August to February 2018 to work in the hospitality business. I am friendly and respectful of people's privacy. I'm looking for sociable flatmates.
Hi there! I'm Mariek, 23 years from Holland! I've been working for a hotel in Sydney since January and living in Redfern. I feel like moving since I miss the home feeling in my house, there is no living room or a nice, cozy place where you can hang out. I'm looking for a private room. I work in the evenings, 5 days a week till 12. I like watching Netflix, chilling on the couch with a glass of wine and I like to chat, but I appreciate also to relax on my own after a long day at work. I am a smoker, and I adore pets! Looking for a room asap, preferably moving this week! Cheers!
I'm a language teacher from New York. I'm mature, responsible and very tidy.
I am friendly, sociable, confident,an very clean nd tidy. Into Fitness and Music. Love to cook
Hi I'm a mature 28 year old female, temporarily needing a place in Syndey for 6 months due to work commitments. I'm from rural NSW and am a relaxed clean person. Looking for a furnished private room (doesn't have to be fully furnished, just the basics like a bed, wardrobe etc) Im looking for a home away from home, not a party house.. I like to relax on weekends as well as trailing through the local markets. Will need to move in around 30/7/17, starting work on the 2/8/17 in Sydney CBD. I have a small car and would prefer a property with available street parking.
I am looking for a room with private bathroom in Sydney or Melbourne. I would like to start with a short term of 2 weeks before decinding for a longer term. I speak french, spanish and english. I am relaxed but not looking for a party house, I would like my own bathroom and private room.
I am a professional programmer, I have been working for multi national corporations for the past 8 years. I am very well travelled. Originally from Cairo, Egypt. And decided to move to Sydney.
Positive, easy going, tidy, friendly, honest, reliable, clean 31 yo professional. I'm respectful and well... pretty easy to live with (I hope). I like the beach, sunshine, coffee, podcasts, dancing, yoga, books and Modern Family. I'm looking for somewhere clean and sunny on the train line/a bus route to Chatswood, ideally with a carspot and with great people.
Nathalia and I are looking for a room, we are a very sociable and easy going couple. We are clean and quiet. Like to enjoy weekends watching movies or going out for drinks. Happy to share dinner and experiences with house mates.
Single, professional, super-tidy guy looking for long-term accommodation in a relaxed and friendly place, preferably unfurnished with own bathroom and car space.
Sydney sider born and bred. I'm 28 and I work full time as a product manager at an ecommerce store. I work with developers to make dreams come true. In my spare time I gym, read books, cook and wrestle (BJJ). I'm a pretty neat individual and while I'm always down for a chat I respect peoples privacy. If you want to know more just ask!
Hey, I'm a journalist working full time in the city and looking for somewhere quiet and friendly to live.
I am a private person who likes to keep it tidy and clean. I do require a quiet accommodation to be able to accomplish some work tasks at night. I am career focused and dislike house partying neither do I bring guests. I bear minimal presence in the house as well. I have a full-time work in the office and simply head to my room once I arrive home. I'm financially stable and am willing to pay the price for a place with these same strict expectations from other people in the house.
Hi there, I'm Demi :) I'm a cleaning enthusiast (usually makes people happy!) I work full time for a pet sitting company and I'm studying to be a vet nurse so my life is very animal oriented! I'm a sociable person but I also enjoy my own space. I am very respectful, tidy and friendly :)
I'm a young professional working full time as an SEO & Online advertising Consultant. I'm a really very friendly, relaxed, always smiling, in a good mood and easy to get along with. I'm very respectful of people's privacy, quiet and tidy. I always clean after myself and do my best to help create a great atmosphere in the house. Always happy to socialize with my housemates around the occasional drinks / dinners. I lived in 4 shared apartments and can provide references :) PS : Non smoker
Hello, I am a 24 year old legal assistant from Brisbane, and am relocating to Sydney for work in August. I am looking to rent a space where I can unwind after work, and from where I can explore the greater Sydney area. I am quite outgoing, but also treasure my alone time.
We are easy going, we like to have a glass of wine in company but also our privacy, we are nice people that enjoy life and new adventures.
I'm a corporate marketing and communication professional from Brisbane looking to make a move to Sydney. I'm very social and enjoy food and good wine, but I also enjoy being a vegetable at home. I am also in a wheelchair but can still walk, and am probably more independent than most people.
Hi there! I'm a very clean housemate who will be working full time. I enjoy going to the gym, eating lots and hanging out with friends. I won't be very loud and will keep to myself most of the time.
Hello, my name is Jennifer and I have just come back from a months travel in Hobart; and I am on the look out for a new space to call home. I am currently working full time as an Assistant Manager at Life with Bird, alongside work I am a part time Arts Writer and often found creating away a bunch of art pieces various exhibitions. Quite quiet during the work week but also fairly social, love a casual cider. I am also a big film buff whom loves a coffee. Super friendly, always open for a chat but will be respectful of people's alone time. The little light of my life is my dog Louie whom is a cute Jug (jack russell x pug), he is small with a big personality; and full of heart. He is house trained and i'd be happy to provide photos and a reference if required. X
extremely clean, non-smoker, friendly, easygoing down to earth fun!!
We are from India and super warm people. We are friendly and accommodating.
Thanks for checking out my profile! I'll be in Sydney for 4 months- from late September to late January 2018- doing a show with Sydney Theatre Company and I'm looking for somewhere to lay my head, relax and rehearse a little bit. I'll be riding my bike around so somewhere within 15km of Dawes Point is ideal. I won't be bringing any furnishings so a furnished room would be top priority but unfurnished isn't something I can't work with. I'll be relocating from Melbourne so I won't have a lot of opportunity to inspect in person, really happy to Skype/Facetime an inspection. Happy to get to know you over the phone. I'm 26 years old, my favourite things to do are bike riding, chilling out watching YouTube, listening to music, playing my piano, playing some video games, cooking and juggling. Have you ever eaten koshary? You're gonna. It would be nice to move into a place with a sociable someone with similar interests, but that's not a deal breaker. I'm a conscientious person who keeps tidy. I do tend to generate a lot of noise but am very aware of when it's appropriate and when it's not welcome. I'll be working days during September-October while we rehearse and nights when the show season starts in November and that'll continue until the end of January. Looking forward to hearing from you.


text:
The RA-02 is a semiauto, direct-impingement rifle that was designed in 1949 by Ramos Arms. It's intended peurpose was as a civilian sporting rifle but as South East Asia errupted into conflict, it was soon marketed to military forces.
After fleeing to Australia and spending most of the family savings on rebuilding a weapons manufacturing plant the Ramos Arms company needed a commercial success to help get the company afloat. After the slow gains of the RA-01 on the civilian and military market the Ramos Arms company needed a design fast. So Marco Ramos, the head designer and founder of Ramos Armas decided to put all his best designs together to create a weapon that needed little development costs. The RA-02 takes its bolt design from the FCA modelo 1938, it's receiver was derived the FCA modelo 1905 carbine, and it shared the same cartridge as the FCA Modelo 1935. When the gun hit the market just a year later from the design phase in 1949 it was an immediate commercial success, quickly becoming a favorite rifle for farmers, ranchers, and law enforcement. In 1957 with the war in Vietnam intensifying the need for more military weapons became apparent. Ramos Armas redesigned the gun to fire the new 7.62x51 Nato cartridge so that it could be easily adopted by western alligned nations. during the war the RA-02 was part of a munitions package consisting of the (RA-02, RA-03, RA-04, and RA manufactured ammunition) sold to south Vietnamese forces to help bolster their firepower. On the global market the RA-02 competed against the FN FAL and the AG-56.
Details (RA-02 7.62x51 Nato) Edit
Weight: 6.4 lb
Length 38.0 in
Barrel length: 22.00 in
Cartridge: 7.62×51mm NATO
Action: Gas-operated, Direct impingement, rotating, closed bolt
Rate of fire: Semi-automatic
Muzzle velocity: 2,800 ft/s
Feed system: 10, 20-round magazines
Sights: Iron sights


text:
35mo ago 32 min 40 sec
Femdom Jess West And Pal Jerk Classmates
by purecfnm245,951 33mo ago 88%
Monster Cock
by buckylake58,350 50mo ago 70%
Cody Lane Horny Babe Fucked
by jacob44465,305 46mo ago 89%
The Gorgeous Cody Lane Sucking A Huge Boner
by dubb47,756 58mo ago 88%
Jess West - The Virgin Sister
by RennRodgers90,915 30mo ago 95%
Cody Gangbaged Hard Grate Video
by Tom.5_1417,527 30mo ago 96%
Dj Salvatore Schiera - Discipline Step Brats
by djoscarleal117,546 30mo ago 88%
Jessica Jaymes - Classic Blow
by Braistorms28,215 38mo ago 91%
Blonde Yoga Babe Hottie Doggystyle Fuck
by wickedme330,749 36mo ago 90%
Beautiful Milf Babe Dylan Ryder Lets Student Fuck Her After...
by hdvpass42,922 40mo ago 92%
Teacher And Student Sex Italian Porn - Sexy Luna
by Disidia58,899 37mo ago 86%
Dj Oscar Leal - So Wrong But Feels So Right!
by djoscarleal233,750 29mo ago 93%
Christmas Fucking With Two Blonde Nymphos
by CindyCA11,587 31mo ago 80%
Two Sluts Are Devouring A Hard Dick!
by CindyCA8,690 31mo ago 83%
Blonde Babes Playing Hot Ball And Dick Game In Outdoor Thre...
by CindyCA8,318 31mo ago 86%
Nicole Aniston - Spin Class Ass
by Azuzano92,034 31mo ago 88%
Sophia Loves To Fuck Young Man
by hustler16,443 32mo ago 77%
Foxy Di Gets Analyzed By Teacher
by dabull13664,476 33mo ago 97%
Subtitled Japan Schoolgirls Classroom Masturbation Cafe
by jaldan211,921 42mo ago 76%
Pov School Of Fucking130,836 56mo ago 84%
Horny Teen Gives A High Class Blowjob23,390 56mo ago 87%
Pretty College Babe Class Room Solo224,000 57mo ago 84%
Pretty Naughty Babe Class Room Fuck175,221 58mo ago 87%
Petite Asian Babe Class Room Hard Sex139,890 58mo ago 81%
Art Class Turns Anal Fuck114,068 58mo ago 83%
Sex Education Class146,847 58mo ago 80%
Sexy Soccer Teen Teasing Her Pussy With A Pink Dildo
by cokito12257,864 63mo ago 85%
Deep Throat 101 Class For Teen Newbie Allison
by PerfectGonzo26,268 38mo ago 86%
College Freak Skipping Class To Fuck
by Onyxx19,910 46mo ago 56%
Anal Love With Aletta Ocean, Her Perfect Tits And Her Blowj...
by saboom71,102 42mo ago 95%
After Collge Class
by PerfectGonzo9,914 38mo ago 79%
Desi School Lesbian Girls In A Hot Spy Cam
by jaymehta0000275,539 61mo ago 78%
Stark Naked Excercize Class Jack Off
by zal666842,466 62mo ago 79%
Babe Taissia Shanti Pounded In The Classroom
by digitalp68,702 36mo ago 88%
Subtitled Enf Cmnf Crazy Japanese Cum Spattered Teacher
by jaldan257,343 50mo ago 79%
Subtitled Japanese Kurumi Morishita Enf Cmnf Striptease
by jaldan213,370 49mo ago 81%
Teacher Fucked In The Classroom
by GCharmer19,914 29mo ago 94%