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How Alcohol Affects The Adolescent Brain
A recent study has revealed that the damage drinking does to adolescent brains has long lasting effects. The region of the brain that regulates learning and memory is affected the most. The latest research was conducted by a team at Duke Medicine with rodents standing in for humans.
Their published findings are shedding light on how alcoholism affects the brain on a cellular level in young drinkers. The study makes a strong case for increasing efforts to educate young people about the deadly effects of alcohol and binge drinking.
A big reason why such serious damage is done by alcohol to the brains of young drinkers is because the development of their brain is still occurring. Even after reaching the legal age of 18 years, a young person's brain continues to mature all the way up until their mid twenties.
This means that heavy drinking done during this critical period may have irreversible damaging effects. The result could affect a person's behavior and cognitive abilities for life.
The team conducting the study wanted to expand on earlier research they had done on rodents that showed how animals exposed to alcohol in their early developmental years had much more difficulty with memory tasks than animals who weren't exposed to alcohol. They knew the damage was connected to alcohol consumption, but weren't sure how exactly the impairments originated in the brain, specifically in the hippocampus.
In order to conduct their latest study, researchers at Duke gave a group of young rodents enough alcohol to impair their mental functioning but not sedate them. As the rodents grew into adults, the regular doses of alcohol were stopped and they were allowed to reach full grown size. The whole process lasted 29 days.
This time, the researchers focused specifically on activity in the hippocampus by using electrical stimuli. They found that brain synapse activity was stronger during learning activities and when conjuring up memories.
The brain seems to rely on this kind of vigorous synaptic activity in order to ensure that essential learning tasks are completed. This type of neurological activity is especially important for adolescents who are acquiring and retaining large amounts of information on a day to day basis.
In the study, the rodents who were exposed to alcohol during their formative stages were shown to have hyperactive synapse activity. This means there was an excess of activity that prevented the animals from acquiring any more information.
The researchers also observed a structural change in the nerve cells in their brains. Early exposure to alcohol seems to have limited the development of these nerve cells causing them to remain in an immature state.
The Duke researchers concluded that early and regular consumption of alcohol led to behavioral immaturity based on the way the hippocampus, brain cells, and other regions of the brain associated with learning and cognitive ability are affected. Learning, impulsiveness, and emotionality are also affected by the damage alcohol does to these brain regions.
The researchers believe that alcohol most likely has an effect on the neurological maturation process that leads to changes in cognitive ability later on in adulthood. Future studies will probably focus on how alcohol consumption affects these necessary functions. The researchers at Duke also want to start looking closer at the cellular changes caused by early alcohol consumption and the long term effect it has on cognitive ability.


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The Orphiro Fully Electric Motorcycle
The Orphiro Electric Motorcycle is described as a wide body cruiser, designed over in Holland. Orphiro combines all ideals when it comes to new motorcycling: cool design, fully electric, fast loading and comfortable driving. This eco-friendly bike relies on Li-ion batteries and the 72V electric motor offers a top speed of 75 mph (120 kph).Continue reading →

subset: commoncrawl


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s-10 t-5 help and Rear Main Seal question
Discussion in 'The Garage' started by big83chevy4x4, Mar 6, 2003.


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|Language Courses
A podcast for those wanting to learn or improve their English - great for any ESL or EFL learner. Visit us at http://www.eslpod.com.
March 31st, 2014
Episode 63 of 489 episodes
Is everything you inherit valuable? Find out in this episode about family heirlooms. Slow Dialog: 1:16 Explanation: 3:28 Fast Dialog: 16:19 Anne: Where are you going with that? Ivan: I'm taking this clock to an antique dealer. Rather than having it gather dust on the mantelpiece, I thought I'd get it appraised and maybe sell it. Anne: You can't sell that! It belonged to our grandfather. It's a family heirloom. Ivan: It's not a family heirloom. It's just a clock that Grandpa had in his house. He didn't mean for it to be passed down from one generation to another. I don't even know if it's valuable or collectable. These clocks could be a dime a dozen. Anne: But it's valuable to me. It has sentimental value. As a little girl, I remember visiting Grandpa and seeing that clock on his shelf. If I had inherited it, I know I wouldn't be looking to sell it to make a quick buck. Ivan: I'm not looking to make a quick buck, but what if Grandpa left it to me because he knew I would be able to put the money that it would fetch to good use? Anne: Well, are you? Are you going to put the proceeds to good use? Ivan: Sure, of course I am. Anne: Are you going to tell me what you're spending it on? Ivan: Not on your life! Script by Dr. Lucy Tse
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Welcome to the Brain Training Podcast, the daily audio workout for your head. In this podcast we have two games for you, each with three rounds which get progressively harder. To enjoy the full experience, relax, and avoid distractions whilst you listen.


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This article is the article listing quotes said by Funky Kong throughout the entire Donkey Kong series.
Donkey Kong Country
Self Greetings
- Whoa, Dudes! My name's Funky Kong!
- My bodacious Jumbo Barrel can take you to any point on the island!
- Most unfortunately, it can only send you to a place you have already been to... which is a complete and total bummer, let me tell you!
To both Kongs
- Yeah, crucial Kongs! If you feel the need for speed, jump in and like, jet!
- You dudes need some lives or something? Jungle Hijinxs is the place for that!
- Yo Gorillas! Go see old man Cranky, he can help you out!
- Lookin' good, Kongs! Buckle up and blast off, you're outta here!
- If you guys see Candy on your travels, tell her I'll give her surfing lessons anytime!
Only DK
- Fancy a flight, DK Dude? You know the score, hop in and high tail it!
- Whoa, Donkey dude! Maybe your little surf buddy's on another level. Go check 'em out!
Only Diddy
- Yo Diddy cool! Lost the big guy again? Blast off back and see the scene!
- Still talking to yourself, huh? Check out the jungle, I'm sure you'll find your buddy!
Donkey Kong Country 2: Diddy's Kong Quest
Donkey Kong Land 2
Donkey Kong Country 3: Dixie Kong's Double Trouble!
Donkey Kong Country animated series
- "When ya wanna be there like now, Funky's Flights is the way to go!"
- "Too late, lizard lips! The babes went cruisin' with what you're losin' from the second you made the scene!"
- [while flying upside-down] "Whoa! Check it out, dudes! Never saw green clouds before... well, maybe once. Hey! Where'd all that water come from?!"
- "Like the terminal dude said... I'll be back!"
- [Funky and Bluster are hiding under a mine cart]
- Funky: Whoa! Maybe the kids have doom-swooped the island!
- Bluster: What will we do?
- Funky: Only thing we can do. Chill here and wait for the others to give us the 'All Clear' sign.
- Bluster: But that could take a long time!
- Funky: So, we get to know each other. I'll tell you my middle name if you, like, tell me yours.
- Bluster: LET ME OUT OF HERE!!!
- Cranky: I think I just spotted Eddie!
- Funky: I am ready, dude!
- Cranky: Not ready! Eddie!
- Funky: Not ready yet? Just say when!
- Cranky: Isn't there something you can do so we can communicate?
- Funky: [does something on the control panel and the noise stops] All right. So, let's communicate.
- Cranky: What did you do?
- Funky: Turned the engine off.
- Cranky: Then... what's holding us up?
- Funky: Like... [the plane starts to fall] ...nothin'.
- Funky: I got that zombie stuff from a movie I saw on the late, late, late, late show!
- Candy: You see? There's no such thing as interplanetary visitor dudes!
- Funky: Not ones that turn people into zombies, anyway. The ones I've met have always been real mellow... in an alternate life-form kind of way.


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Home > About Us > Quality & Awards
Over the past two years alone, Rutland Regional Medical Center has received 17 national awards and recognition that support our unwavering commitment to being the best community healthcare system in New England. Below is a list of some of the awards and recognition that help us measure the quality of care we provide to our patients every day.
In December 2015, Rutland Regional was re-designated as a Magnet® organization for excellence in nursing by the American Nurses Credentialing Center's (ANCC) Magnet Recognition Program. A highly selective program, only 378 out of nearly 6,000 US healthcare organizations have achieved Magnet status, one of the highest achievements an organization can obtain in professional nursing. Read More>>
Healthgrades, the leading online resource helping consumers make informed decisions in order to find the right doctor, the right hospital and the right care, has recognized Rutland Regional Medical Center with the 2015 Healthgrades Patient Safety Excellence Award™ and the 2015 Healthgrades Outstanding Patient Experience Award™. Rutland Regional is among the top 10% in the nation for Outstanding Patient Experience and Patient Safety. Read More>>
Rutland Regional Medical Center has been named a recipient of five Specialty Excellence Awards, including: Five-Star Recipient for Total Knee Replacement-2017; Five-Star Recipient for Gallbladder Surgery-2017, Five-Star Recipient for Pacemaker Procedures-2015, Five-Star Recipient for Transurethral Prostate Resection Surgery-2015; Recipient of Healthgrades Prostate Surgery Excellence Award 2013-2015; and Top 10% in the Nation for Prostate Surgery 2013-2015. Read More>>
Rutland Regional Medical Center has been awarded The Advisory Board Company's 2016 Workplace Transformation Award. The annual award recognizes hospitals and health systems nationwide that have made a transformational change in their employee engagement. Engaged employees, as defined by The Advisory Board Company, are those who exhibit both loyalty and commitment to the organization. These employees are willing to expend discretionary effort, often going above and beyond to help the organization succeed. The award recognizes Rutland Regional's commitment to creating a best-in-class work environment for its employees. Read More>>
Rutland Regional Medical Center has been named among the nation's best hospitals in the U.S. News & World Report Best Hospitals for Common Care. Most recently (2016-17) Rutland Regional was rated as High Performing in chronic obstructive pulmonary disease (COPD), heart failure, and hip replacement. The ratings evaluate more than 4,500 hospitals nationwide on common inpatient procedures and conditions.
In the Fall of 2016, Rutland Regional received its most recent "A" Rating for hospital safety from Leapfrog, one out of over 2600 hospital across the US to receive the highest rating. Leapfrog is an independent, national non-profit organization that advocates for patient safety nationwide. The Leapfrog Hospital Score measures hospital performance in areas related to reducing injuries and accidents, as well as preventable medical and medication errors. Visit the Hospital Safety Score website to learn more about safety ratings.
In 2017, the American Hospital Association announced that Rutland Regional Medical Center is recipient of Healthcare's Most Wired® award for the second year in a row. The award is in recognition for the exceptional way the hospital uses technology to build patient engagement, specifically in how the patient is afforded electronic access to their care team. Rutland Regional utilizes population health management tools and partners with other healthcare providers to share critical clinical information. This information is then used to analyze interventions and is aimed at key patient groups such as those with diabetes. Read More>>
The Joint Commission has recognized Rutland Regional Medical Center with its Gold Seal of Approval® in 2014 for its dedication to continuous compliance with the joint Commission's State-of-the-Art standards. A team of Joint Commission expert surveyors evaluated Rutland Regional for compliance with standards of care specific to the needs of patients, including infection prevention and control, leadership and medication management. The Gold Seal indicates that Rutland Regional meets the Joint Commission's rigorous performance standards in delivering quality, safe care. The Gold Seal is an internationally recognized seal of quality. In 2013 The Commission recognized the hospital as a Top Performer on Key Quality Measures® for its excellence in accountability measure performance shown to improve care for certain conditions, specifically outcomes around Heart Failure, Pneumonia and Surgical Care. Read more>>
In Summer 2014, Rutland Regional Medical Center was the recipient of the Studer Group® 2014 Excellence in Patient Care Award for Decreased Left Without Being Seen. This award is based on data that shows a significant rate of change and/or substantial achievement in reduction of Left Without Being Seen within an organization over recent fiscal years. For more information on The Excellence in Patient Care Awards, visit the Studer Group® website.
In 2016, Rutland Women's Healthcare was named a named a Blue Distinction Center for Maternity Care. The Vermont Orthopaedic Clinic is also a Blue Distinction Center for Total Hip and Total Knee Joint Replacement. Blue Cross and Blue Shield of Vermont awards a Blue Distinction as a way to identify hospitals that deliver quality specialty care safely and effectively, based on objective measures with input from the medical community. Read More>>
The Vermont Governor's Council on Physical Fitness and Sports has awarded Rutland Regional Medical Center the 2015 Governor's Excellence in Worksite Wellness award. The award recognizes Vermont employers who have made programs and initiatives that encourage staff to make healthy choices a priority. In May 2010, Rutland Regional Medical Center received the Governor's Award for Performance Excellence. The Governor's Award for Performance Excellence recognizes organizations in Vermont that successfully achieve performance excellence within their management systems and operations. Award recipients are evaluated by an independent board of Vermont Performance Excellence Examiners in seven areas: leadership; strategic planning; customer focus; measurement, analysis and knowledge management; workforce focus; process management; and results.
RUTLAND REGIONAL MEDICAL CENTER160 Allen Street, Rutland, VT 05701802.775.7111


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|Message view
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|"Eli Collins (JIRA)" <j...@apache.org>
|[jira] Updated: (HDFS-1473) Refactor storage management into separate classes than fsimage file reading/writing
|Sun, 28 Nov 2010 21:47:37 GMT
[ https://issues.apache.org/jira/browse/HDFS-1473?page=com.atlassian.jira.plugin.system.issuetabpanels:all-tabpanel ] Eli Collins updated HDFS-1473: ------------------------------ Resolution: Fixed Fix Version/s: 0.23.0 0.22.0 Hadoop Flags: [Reviewed] Status: Resolved (was: Patch Available) Thanks Todd! > Refactor storage management into separate classes than fsimage file reading/writing > ----------------------------------------------------------------------------------- > > Key: HDFS-1473 > URL: https://issues.apache.org/jira/browse/HDFS-1473 > Project: Hadoop HDFS > Issue Type: Sub-task > Reporter: Todd Lipcon > Assignee: Todd Lipcon > Fix For: 0.22.0, 0.23.0 > > Attachments: hdfs-1473-prelim.txt, hdfs-1473.txt, hdfs-1473.txt, hdfs-1473.txt > > > Currently the FSImage class is responsible both for storage management (eg moving around files, tracking file names, the VERSION file, etc) as well as for the actual serialization and deserialization of the "fsimage" file within the storage directory. > I'd like to refactor the loading and saving code into new classes. This will make testing easier and also make the major changes in HDFS-1073 easier to understand. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online.
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The Little Prince (2015) 1080p BRRip DD5.1 HEVC X265-RMTeam
Size: 929491744 bytes (886.43 MiB), duration: 01:46:00, avg.bitrate: 1169 kb/s
Audio: aac, 48000 Hz, 5.1, s16 (eng)
Video: 1920x816, 24.00 fps(r) (eng)
Genre: Animation, Fantasy
iMDB iNFO
A little girl lives in a very grown-up world with her mother, who tries to make sure she is prepared for it. Her neighbor The Aviator, introduces the girl to an extraordinary world where anything is possible, the world of The Little Prince.
Buy Premium Account From My Download Links And Get Resumable Support & SUPER Fastest speed
http://uploadgig.com/file/download/5418574e09591AbB/The Little Prince 2015 1080p BRRip DD5.1 HEVC X265-RMTeam.mkv


text:
Best Western Hotel Europa
Lungomare Zara 57 •
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4 star hotel in Giulianova
This Hotel in Giulianova is located by a wonderful beach of the Abruzzo coast. Modern building set in an amazing seascape. The careful family management offers a warm hospitality.
Tasteful rooms, with all modern comforts, in-room movies -Pay-per-view movies, cable satellite television with NBC, CNN and SKY TV. Renowned seaview restaurant with air-conditioning. Meeting room, Internet point, car park.
Wide private sand-beach. Animation and baby-club (in summer).
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GPS: lat. 42.758050 long. 13.966660
Modern building set in a charming landscape: overlooking the most beautiful beach of the Abruzzo coast, with a wide private sand-beach and a pool with hydro massage. 4 equipped meeting rooms, suited to welcome up to 150 people. Car parking at guests' disposal. Renowned restaurant with sea view.
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A twist on risotto by using pearl barley gives a really creamy, nutty and comforting taste and texture to this dish. Add some fresh asparagus, chicken and leek and it's a great winter comfort food!
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2 cups of pearl barley (or can use 1 cup of pearl barley and 1 cup of arborio rice)
A knob of butter and splash of olive oil
1 leek, washed and chopped
250g of washed and chopped asparagus
1 large chicken breast, slice and diced
1/2 cup of chopped fresh parsley
Salt and pepper to taste.
1 to 1 1/2 litres of hot Chicken stock or mixture of stock and white wine
In a large saucepan heat the olive oil and butter then add the leek, pearl barley and arborio rice. Sautgently to soften for about 5 minutes then add a cup or more of hot stock. Stirring, rapid boil for about 5 minutes until liquid is absorbed.
Turn heat down then continue to add stock half a cup at a time and stirring often allow the liquid to absorb. As absorption is reached and before sticking to the bottom add more stock. Continue for about 20 minutes, by which time the pearl barley should be softening.
Add the diced chicken meat, stir well and add more liquid and maintain a low simmer for about 10 minutes, continuing to add hot stock. Then add the chopped asparagus and continue for about another 10 minutes. If you run out of hot stock and its still a bit al dente add some hot water!.
The whole cooking process should take about 40 minutes. This can be hastened by par boiling the pearl barley on its own in which case it will not need so long in the risotto pan.
Finish with plenty of fresh ground pepper the chopped parsley and a real thorough stirring!
Cover the pot; take off the heat and leave to stand for at least 5 minutes before serving. Covered it will keep hot for at least 10 minutes.


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Mark Salling Celebrates His Solo Album in Vegas (PHOTOS)
To celebrate the release of his new CD Pipe Dreams, Glee hottie Mark Salling spent the weekend partying it up at TAO in Las Vegas.
Along with his new costar Chord Overstreet, the boys took Vegas by storm. Also helping them celebrate? Stars Rumer Willis, Stacy Keibler and Bam Margera.
Pipe Dreams, which is Mark's first solo effort, will also help raise awareness for the American Red Cross. Pre-sale for the album has already sold out, but you can pick it up when it hits stores later this month.
Pipe Dreams EPK Teaser from Mark Salling on Vimeo.
Will you pick up a copy of Pipe Dreams? Or do you think he should stick to Glee? Give us your thoughts in the comments!


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|"Scherler, Thorsten" <thors...@apache.org>
|Re: [RT] Skin names and skin cleaning
|Sun, 27 Jun 2004 22:54:20 GMT
Hi nicola, >> - desactivate the font size script > > I would prefer not to, it's an important part for accessibility. ...I had to because of the feedback in lenya-dev, so I started to patch the skinconf.xsl: I added <!-- If true, the font size script will not be rendered --> <xsl:if test="not(disable-font-script)"> <disable-font-script>true</disable-font-script> </xsl:if> Then I added to site2xhtml.xsl <!-- If true, the font size script will not be rendered --> <xsl:variable name="disable-font-script" select="//skinconfig/disable-font-script"/> The above mentioned patches where in skin/common. Then I patched the site2xhtml.xsl of the krysalis-site like this: <xsl:if test="$disable-font-script = 'false'"> Font size:  <input type="button" onclick="ndeSetTextSize('reset'); return false;" title="Reset text" class="resetfont" value="Reset"/>  <input type="button" onclick="ndeSetTextSize('decr'); return false;" title="Shrink text" class="smallerfont" value="-a"/>  <input type="button" onclick="ndeSetTextSize('incr'); return false;" title="Enlarge text" class="biggerfont" value="+a"/> </xsl:if> Last but not least I declared the disable-font-script element in the skinconf.dtd to use it like follow in my skinconf.xml <!-- If true, the font size script will not be rendered --> <disable-font-script>true</disable-font-script> Now I can turn it on and off like I want :). If you like I can open an issue for that and attach the patch. ...or I can commit that directly? I do not know whether we have feature freeze for the new release, so just tell me what you prefer. I will write more commands tomorrow. thorsten Nicola Ken Barozzi wrote: > Scherler, Thorsten wrote: > ... > >> For the moment I have some enhancement questions about the >> krysalis-site skin. >> >> Is it possible to: >> - move the left logo a wee bit to the left > > > Sure. > >> - move the right logo to absolute right (if no search box is activated) > > > Sure. > >> - desactivate the published notice on the top right > > > Make it an option in skinconf. > >> - desactivate the font size script > > > I would prefer not to, it's an important part for accessibility. > >> - move the build with forrest logo into the footer > > > You mean all the credits? Make it an option in skinconf. > >> - desactivate the 'breadcrumb trail' of links > > > Make it an option in skinconf. > >> - enhance the tab bar menu in terms of font size >> with configuration of the skinconf.xml. > > > You can put some CSS in the extra-css, or simply make your version the > default one if it's nicer :-) > >> I would like to configure that from the skinconf.xml. If that is not >> possible so far is that form interest to implement? > > > The above should be easily doable. > >> Or should I use for this parts an overriding custom xsl? > > > I'd really like to avoid custom xsl. > -- <thorsten> <name>Thorsten Scherler</name> <country>Spain</country> <@mail>thorsten.at.apache.org</@mail> <@cocoon-WIKI>http://wiki.cocoondev.org/Wiki.jsp?page=Scherler</@cocoon-WIKI> <http>http://www.target-x.de</http> <acronymfinder>http://www.acronymfinder.com</acronymfinder> <motto> "My task which I am trying to achieve is, by the power of the written word, [...] to make you see." *Joseph Conrad (1857-1924)* </motto> </thorsten>
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This early 1960's narrow black silk polka dot necktie is a classic. The basic color of the necktie is black with a red polka dot design. The maker's label takes us back to a time when men's store's had their own labels for ties, identifying this as "Hamer's, Spokane, Pullman." A smaller label gives the fabric content as "All Silk" with an RN number of 15529 on the back
The necktie measures 56 inches in length and is 2 ½ inches across the tip – almost but not quite a skinny tie. The label has some minor fraying, and there is a small thread pull on the blade. It is otherwise in excellent vintage condition with no spots, stains, holes, or scents, and it has been professionally dry cleaned. This vintage black silk necktie with its red polka dots has a classic look and will be a great addition to your tie collection.
3 other shoppers have this item in their Cart or Wish List .
An eclectic selection of original jewelry, classic accessories, and vintage jewelry.
Welcome summer with unique artisan jewelry or fabulous vintage finds!


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The Imaging software we use is pretty particular about where fields are on the screen when it goes to capture them to associate them with the document being scanned(besides that I love how ImageNow works). I'm wondering if I can use group policy to force all instances of IE on our network to look the same i.e. only display the menu bar, the status bar, and/or use Large Icon's etc. so that I don't have have to multiple Imaging profiles for our users(based on their various IE toolbar installations).
Apr 14, 2010 at 11:18 UTC
Download the ADM file for IE and you should be able to do all or most of this, just set what you need and restrict users from making changes.
7 Replies
Apr 14, 2010 at 11:18 UTC
Download the ADM file for IE and you should be able to do all or most of this, just set what you need and restrict users from making changes.
Apr 14, 2010 at 11:24 UTC
(slaps head) I deal with Group Policy so infrequently these days I'd forgotten about the ADM templates... (groan). Thanks. :)
Apr 14, 2010 at 11:26 UTC
Glad to help, glad it was something easy :)
Apr 14, 2010 at 11:29 UTC
Well I think it's going to be a bit tricky I took a quick look through the policy settings for IE 8 and I see some of the things I'm looking for, lock toolbar, use large icons, what I don't see is one that references disabling any/all 3rd party bars, like the one Adobe adds, etc...
Apr 14, 2010 at 11:44 UTC
You could use the GPO "disable add-ons"
Apr 14, 2010 at 11:52 UTC
Yup I think that's it I'm going to apply these and test them in a bit. Thanks so much both of you.
Apr 15, 2010 at 9:22 UTC
Personally I would use IEAK and then roll it out with a GPO.
I like branding and you can brand IE with IEAK.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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text:
Quadruple Crazy: DIY Shutter Lock for Your Actionsampler2012-04-18 1 8 Share Tweet
Tired of getting unwanted or accidental clicks from your Actionsampler especially when you're traveling? Want to put on a shutter lock to it but don't know how? Read on to know more!
I always carry my Actionsampler with me whenever I go on an out of town trip. It's nice to capture motions of people, dogs, cats, cars, and even yourself using this four-lensed compact camera. The only thing that makes me think twice in bringing my Action Sampler with me are the accidental clicks that happen whenever I put it in my bag, my pocket, or even when it's hanging around my neck! The main reasons for it is number one, the shutter is so sensitive that a soft touch to the shutter button will take a picture, and number two, it doesn't have a shutter lock. To end my dilemma, I used a film canister cap to make a DIY shutter lock.
Things you need:
- film canister cap
- knife
- tape (I used masking tape)
- and of course, your Actionsampler
Step 1:
Cut a cross in the middle of the film canister cap like the image below. This is for you to easily press the shutter without any extra effort.
Step 2:
Place it on top of your camera and secure it with a masking tape.
And you're ready to roll!
Note that this can also be done in other cameras that doesn't have any shutter locks like Vivitar UWS, Oktomat, et al.
The Actionsampler Chrome snaps up a series of four images on one 35mm print. This multilens camera records your subject's movement and is now coated in sleek silver. See it with the rest of our Multilens cameras here!
written by superkulisap on 2012-04-18 #gear #tutorials #diy #camera #homemade #tipster #canister #action-sampler #protection #quickie-tipster #shutter-lock


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As part of our rigorous testing the KAK60 kettle was filled, boiled and emptied over 3000 times, that should be enough hot water to make over 23,000 cups of tea. We do this to be sure that Kambrook is the smarter choice.
Built tough and durability tested.
All Kambrook products are built to the toughest standards. Every new Kambrook product is tested in our Australian labs for safety, durability and performance. That is the Kambrook guarantee.
© 2012 Kambrook


text: Game Paintball football online Online Games › Sports › Paintball football Online Games › All genres › Desktop › Balls Very entertaining sports game Paintball football attract unshakable interest. You are invited to an interesting playing field in which to run the game ball. You control the ball arrows playing field. Make an effort to not coveted ball ended up in the gate and point it at the opposite site. Ball, passing interesting way relates colored buttons and thereby earns balls. Interesting flash bid online, like many of its simplicity and passion. 0.00 357 0.00/5 Played: 714 Full screen [To restore the default size ]


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Are these breast reduction scars hypertrophic or keloids? Will scar revision help? (Photo)
Doctor Answers 7
Keloid scars overgrow the boundary of the original incision, these do not look like keloid scars. You have some slight hypertrophy but really the thing I see most is the redness. Redness in scars is variable, seems worse in fair skinned people, but improves significantly with time. Please be patient with your scars, avoid sun exposure. I would not recommend any scar revision until at least 6 mo postop, and then very cautiously. Good luck, Jane
Breast Reduction Scaring
You have hypertrophic scaring. It is very early in your recovery, and 3 months is too soon and perhaps not the right method of scar improvement. I usually wait a few more months before trying a vascular laser. Sometimes a few treatments are necessary to improve color, itchiness, and thickness. Silicone sheeting should also be used during this period. In fact, silicone sheeting would be good right away for you.
In the past, injections of corticosteroids was considered appropriate, but this can leave the scar looking depressed, discolored, and wide. I would not consider surgical scar revision until laser therapy has been attempted.
Best of luck!
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Breast Reduction and Scarring
Congratulations on your breast reduction surgery, as it is life changing.
You are very early on during your healing and I would not consider scar revision at this time. I generally have my patients start a scar treatment program which includes using silicone tape early on to help prevent hypertrophic scars. I also generally ask them to keep the area out of the sun for the first year. If they are going to have sun exposure, good sunblock with zinc oxide is recommended.
I generally don't advise for scar revision until the scars have gone through the healing phase which generally last up to a year. This is because the scar can continue to improve until then.
Good luck.
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Thank you for the short history and photos and I agree with Dr Morgan and would treat these conservatively with Siligen strips and give more time for healing
Dr Corbin
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Breast reduction - are these keloids or hypertrophic scars
Thank you for asking about your breast reduction.
- Your scars at least as seen in the photos are defintely NOT keloids.
- They are minimally hypertrophic scars.
- You should NOT have surgery for at least 6 months after surgery.
- Besides this, surgery is not the standard treatment for keloids.
- You should wear silicone strips over the scars for now.
- At six months, any residual thick scars can be injected with very dilute steroid or methotrexate.
- If the scars are intolerably itchy now, they can be injected sooner.
- It is likely that you will heal with the same kind of scar is you have a scar revision.
- Most plastic surgeons are very good at evaluating scars like this -
- If your surgeon is not a plastic surgeon, I suggest you consult a plastic surgeon before having any further scar treatment from your current surgeon.
Always see a Board Certified Plastic Surgeon. Best wishes - Elizabeth Morgan MD PHD FACS
Breast reduction scars
Thank you for your question. It appears that you have some hypertrophic scarring of your incisions. It can take up to a year to know the final results of any scars. I think you got a really nice result. I would recommend waiting to see what your scars look like at one year time. Good luck.
Learn more: http://www.raoplasticsurgery.com/plastic-surgery/breast-reduction
Incision lines at 10 weeks
Your incision lines are 10 weeks old and by no means keloids; you need to performing aggressive incision line management so that you can optimize your incision line healing; this includes: silicone gell sheeting; IPL; and possible steroid injections; at 6 months you may evaluate your incision lines for scarring.
Learn more: http://drmowlavi.com/breast-surgery/orange-county-breast-reduction-newport-beach/
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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by Staff Writers
Cape Town (AFP) Sept 04, 2014
South Africa has refused to grant a visa for the Dalai Lama to attend the World Summit of Nobel Peace Laureates in Cape Town next month, his representative said Thursday.
The government "conveyed by phone to me they will not be able to grant the visa for the reason that it would disturb relations between China and South Africa," Nangsa Choedon told AFP.
The refusal could provoke a boycott of the 14th annual peace summit, according to a spokesman for South Agfrican laureate and former archbishop Desmond Tutu.
"I have heard that if the Dalai Lama is not allowed into the country, other invited guests have said they will not come," Roger Friedman said.
The government confirmed that it had received a visa application from the Dalai Lama but suggested that a decision had not yet been made.
"The application will be taken through normal due process. The relevant authorities will communicate with the applicant thereafter," the department of international relations said.
Two years ago, the country's top court found that the government had acted unlawfully by dragging its heels on a visa application by Tibet's exiled spiritual leader until it was too late.
China, which accuses the Dalai Lama of covertly campaigning for Tibet's independence, regularly uses its growing economic and political clout to put pressure on governments around the world to limit contact with the Dalai Lama.
China is one of South Africa's major trading partners.
The Nobel summit in Cape Town in October is backed by foundations representing four South African peace laureates -- Tutu, Nelson Mandela, FW de Klerk and Albert Luthuli.
Along with the surviving South Africans -- Tutu and De Klerk -- the organisers say 13 individuals and eight organisations had confirmed that they would attend the summit, including former Soviet president Mikhail Gorbachev.
- Latest refusal -
Choedon said she had not yet received written confirmation of the refusal, but if confirmed, this will be the third time in five years that the Dalai Lama has been refused a visa to visit South Africa.
Each refusal has been met with an outcry from South Africans who feel it is a betrayal of the commitment to human rights embraced by the government since the end of apartheid 20 years ago.
But a spokesman for De Klerk, the South African former president who won the Nobel prize alongside liberation icon Nelson Mandela, said he did not think a boycott of the summit would be the right response.
"I think the message has gone out that boycotting the summit would be the very worst way of protesting," Dave Steward, executive director of the FW de Klerk Foundation, told AFP.
"The best way would be to come to the summit and celebrate the 20th anniversary of our democracy and then make any views they want to make known at the summit."
He said a refusal of a visa for the Dalai Lama would be "the antithesis of the values of our constitution".
The Dalai Lama was last barred from entry in 2011, when he was invited to give a lecture as part of celebrations for Tutu's 80th birthday.
That led to a court challenge by opposition parties, and a finding by the Supreme Court of Appeal that "the matter was deliberately delayed so as to avoid a decision".
At the time, Tutu described the African National Congress government as being "worse than the apartheid government".
The Dalai Lama was also denied a visa in 2009, but had visited three times before that and was personally welcomed by former president Mandela.
The Inkatha Freedom Party, one of the parties that brought the previous legal case, said it would "follow up" on the matter this time too.
"It's embarrassing that the government would go to such lengths to prevent the Dalai Lama from coming here," Sibongile Nkomo, the party secretary general told AFP.
Hong Kong students plan strike for democracy
The move came as a major financial backer of the pro-democracy group that has vowed to take over the city's streets said the axing of his long-running newspaper column was politically motivated.
Activists in the former British colony had their hopes for genuine democracy crushed after China announced on Sunday that the city's next leader would be vetted by a pro-Beijing committee.
The top committee of China's rubber stamp parliament said Sunday Hong Kong citizens will be allowed to elect their next leader in 2017 -- but candidates must be approved by a pro-Beijing committee, with only two to three contenders allowed to stand.
A coalition of pro-democracy groups have vowed to usher in a new "era of civil disobedience" against the decision, calling on the people of Hong Kong to blockade major thoroughfares in the city's financial district.
Students plan to walk away from classes on September 22 in what they described as a final warning before wider civil disobedience action.
The proposal still needs to be approved by a coalition of student groups and unions on Saturday, leaders said.
"We strike as an ultimatum to warn the government to listen to our opinions," president of the Hong Kong University (HKU) student union Yvonne Leung told AFP.
- Students mobilise -
In the afternoon students from Chinese University of Hong Kong met next to a replica of the "Goddess of Democracy" statue on the university's campus -- a throw back to the student-led movement in Beijing that was brutally crushed 25-years ago.
The original statue became a rallying point for pro-democracy supporters in Tiananmen Square and was destroyed in the crackdown.
"We have to make our voices heard, to show the Communist Party we're not afraid, to show them we care about what happens in Hong Kong," 21-year-old Hazel Ng said.
"I want to strike exactly because I love China, free elections will be good for the entire country," added 21-year-old Eddie Mung, a fourth year nursing student added.
As the students met, hedge-fund manager Edward Chin, a wealthy backer of the Occupy Central movement that has threatened civil disobedience called on locals to "uphold" media freedom in the city during a press conference at the Foreign Correspondents' Club.
Chin said the loss of his column in the Hong Kong Economic Journal illustrated how the city's media was under constant attack from mainland authorities.
"I think my column was axed because of political pressure from Beijing," Chin, who is the head of a group of some 80 bankers and finance workers who support Occupy Central.
The paper has previously said the weekly finance column was cut due to a page redesign, not for political reasons.
But Chin said the Economic Journal had become more pro-establishment since he first started contributing in 2006.
A respected Chinese-language financial newspaper, the paper was bought by Richard Li, the younger son of Asia's richest man Li Ka-shing, in 2006.
"If we want to criticise the establishment, whatever you wrote will be edited. It's a sad story for journalism and Hong Kong," Chin said calling on locals to "uphold whatever was left" of the city's media independence.
Concerns over press freedom have grown this year following several attacks on local media workers and accusations Beijing-critical papers have suffered advertising boycotts.
The former editor of a respected liberal newspaper, Kevin Lau, was savagely stabbed in broad daylight in February.
Jimmy Lai, publisher of the popular and often anti-Beijing Apple Daily, is also currently under investigation by the city's anti-graft agency.
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How to Make lollipop charms from polymer clay
Learn how to sculpt donut charms from polymer clay with this free video art lesson. While this tutorial is best suited for those with some familiarity of polymer clay sculpture, novice sculpters should be able to follow along given a little effort. For specifics, including step-by-step instructions, watch this sculpter's guide.


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The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions
Translational oncology
Psoriasin (S100A7) is a member of the S100 gene family. Alteration of Psoriasin expression has previously been reported to play an important role in cancer aggressive behaviour. The current study sought to investigate the level of Psoriasin expression at the mRNA level in a cohort of patients with non-small cell lung cancer (NSCLC), the association with clinical implication and outcomes, and the molecular and cellular impact of the protein on lung cancer cells.
Fresh frozen NSCLC cell carcinoma tissues, along with matched normal tissues were obtained from 83 NSCLC patients who received curative resection from January 2003 to December 2011. The expression of Psoriasin in the NSCLC specimens was assessed using both quantitative real time PCR (QPCR) and immunochemical staining. Knockdown and forced expression of Psoriasin in NSCLC cell lines were carried out using constructed plasmid vectors carrying either ribozyme transgenes targeting human Psoriasin or full-length coding sequence, respectively. The effect of Psoriasin on the functions of NSCLC cells was determined using a variety of
Higher mRNA levels of Psoriasin were observed in tumour tissues when compared to both the paired normal background tissues and none paired normal tissues (p = 0.0251 and 0.0195). The mRNA level of Psoriasin was found to be higher in the squamous carcinoma (P=0.035). Higher Psoriasin expression is associated with poor prognosis. The cell function tests had supportive results to the clinical findings. Over-expression of Posriasin in lung cancer cells (SK-MES-1) resulted in an increase in
Psoriasin expression is increased in lung cancer, more specifically in lung squamous carcinoma compared with adenocarcinoma, and is associated with poor prognosis. Psoriasin plays crucial roles in regulating the growth and invasion of lung cancer cells.
Non-small cell lung cancer (NSCLC) is highly aggressive. Better prognosis and clinical outcomes mainly rely on early detection and curative resection. However, some of these early stage patients have poor prognosis due to metastasis. Real-time-quantitative-PCR-based assay of certain genes may help to identify patients of early-stage NSCLC with higher risks of poorer prognosis
The current study sought to investigate the level of expression of Psoriasin at the mRNA level in a group of surgical patients with NSCLC and to examine the association of this molecule with clinical features and outcomes. We also provide new insights into the biological functions of Psoriasin in NSCLC cell lines.
Cell lines and human lung cancer specimens
Human lung squamous carcinoma SK-MES-1 and human lung adenocarcinoma A549 cells were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). Cells were routinely cultured with Dulbecco's modified Eagle medium (DMEM) supplemented with 10% foetal calf serum, penicillin and streptomycin (Gibco BRC, Paisley, Scotland, UK). Fresh frozen NSCLC cell carcinoma tissues at TNM stages of I to IIIa, along with matched normal tissues, were obtained from 83 patients who received curative resection in Peking University Cancer Hospital and Xuanwu Hospital of Capital Medical University from January 2003 to December 2011. Ethical approval was provided by both Peking University Cancer Hospital and Xuanwu Hospital of Capital Medical University Ethics Committees. Clinical information of the patients is given in Table
RNA isolation and reverse transcription polymerase chain reaction
Total RNA was isolated from the homogenized NSCLC tissues (83 pairs of specimens) and cell lines using Total RNA Isolation Reagent (ABgene™). Reverse transcription was performed using the Reverse Transcription kit (Primer design), followed by PCR using a REDTaq™ ReadyMix PCR reaction mix (Sigma-Aldrich, Inc.). The quality of DNA was verified using GAPDH primers (sense: 5'-ATGATATCGCCGCGCTCGTC-3'; antisense: 5'-CGCTCGGTGAGGATCTTCA-3'). Psoriasin mRNA levels were assessed using Psoriasin primers as follow: F: 5-GGGCACAAATTACCTCGCGA, R: 5-CACTGGCTGCCCCCGGAAC. PCR was performed in a GeneAmp PCR system 2400 thermocycler (Perkin-Elmer, Norwalk CT, USA). Cycling conditions for the 16-μl-reaction mixture were 30s at 94°C for denaturation, 30s at 55°C for annealing and 30s at 72°C for elongation (30 cycles). This was followed by a final 10 min extension period at 72°C. PCR products were then separated on a 2% agarose gel. The product was then visualized under ultraviolet light following ethidium bromide staining.
Quantitative real time PCR (QPCR)
QPCR was performed on the Icycler IQ5 system (Bio-Rad, Hammel Hemstead, UK) to quantify the level of Psoriasin transcripts in the NSCLC specimens (shown as copies/μl from internal standard). NSCLC cDNA samples were then examined for Psoriasin transcript expression, along with a set of standards and negative controls. The QPCR technique utilised the Amplifluor system™ (Intergen Inc., England) and QPCR master mix (BioRad). Pairs of primers were designed using Beacon Design software (PREMIER Biosoft, Palo Alto, CA): Psoriasin QPCR primers: ZF: 5-TGTGACAAAAAGGGCACAAA, ZR: 5-
Immunohistochemical staining of psoriasin
Paraffin sections of NSCLC (n = 16) and paired normal lung tissues (n = 16) were cut at a thickness of 6 μm. The sections were first dewaxed using a series of xylene and rehydrated through descending grades of ethanol washes. Endogenous peroxidase activity was blocked with 0.3% hydrogen peroxide for 15 min. For antigen retrieval, sections were boiled in 10 mM citrate buffer (pH 6.0) for 10 min. The sections were then immersed in TBS wash buffer for 10 min to rehydrate and incubated for 20 min in a horse serum blocking solution before probing with the Psoriasin antibody (1:100) (ab13680, Abcam, Cambridge, UK) together with a negative control without primary antibody. Following extensive washing, sections were incubated for 30 min with the secondary biotinylated antibody (Vector Laboratories). Avidin-biotin complex (Vector Laboratories) was then applied to the sections for 30 min followed by extensive washing. Diamino benzidine chromogen (Vector Laboratories) was then added to the sections and incubated in the dark for 10 min. Sections were then counterstained in Mayer's haematoxylin and dehydrated in ascending grades of ethanol before clearing in xylene and mounting under a cover slip. Staining was independently assessed by the authors.
Construction of Psoriasin expressing and ribozyme transgenes, and transfection
The full sequence of Psoriasin was amplified using the standard PCR procedure described above and a master mix with proof reading enzyme, as previously reported
Western blotting
To detect the expression level of FAK in the NSCLC cell lines, confluent cells were pelleted and then lysed using a lysis buffer containing 2.4 mg/ml Tris, 4.4 mg/ml NaCl, 5 mg/ml sodium deoxycholate, 20μg/ml sodium azide, 1.5% Triton, 100 μg/ml PMSF, 1 μg/ml leupeptin, and 1 μg/ml aprotinin, for 45 min at 4°C. After lysis and centrifugation at 13,000 rpm for 15min, protein concentration of each sample was measured using an improved Lowary assay (DC Protein Assay kit, Bio-Rad). The samples were adjusted to equal concentrations with sample buffer and then boiled at 100°C for 5 min, before separation on a 10% polyacrylamide gel. Following electrophoresis, these separated proteins were blotted onto nitrocellulose membrane and blocked in 10% skimmed milk (w/v in TBS) for 1 hour. The membranes were then probed with the anti-phosphorylated FAK at Tyrosine residue 407 (Santa Cruz, CA, USA) and anti-GAPDH-antibody (Santa-Cruz Biotechnologies, California, USA) as internal control, followed by a peroxidase-conjugated secondary antibody (1:1,000). Protein bands were visualised using an ECL system (Amersham, UK), and photographed using an UVITech imager (UVITech, Inc.).
Cells were plated into 96-well plates at density of 2,000 cells/well. The cells were then fixed in 4% formaldehyde after 1, 3 and 5 days respectively. 0.5% crystal violet (w/v) was used to stain cells. Following washing, the stained crystal violet was dissolved with 10% (v/v) acetic acid and the absorbance was determined at a wavelength of 540 nm using a spectrophotometer (Bio-Tek, ELx800). The absorbance of each cell line at day3 and day5 were then normalised against day1 absorbance.
Cell matrix adhesion assay
The cell matrix adhesion assay was done as previously described
Wounding/migration assay
The wounding assay was performed as previously described
Transwell inserts (upper chamber) with 8 μm pore size were coated with 50 μg of Matrigel (Collaborative Research Products, Bedford, Massachusetts, USA) and air-dried. Following rehydration, cells were seeded at a density of 20,000 per insert and allowed to invade for 3 days. After incubation, cells that had migrated through the matrix and adhered to the other side of the inserts were fixed in 4% formalin, stained with 0.5% (weight/volume) crystal violet, and counted under a microscope.
Statistical analysis
Statistical analysis was performed using MINITAB version 13.32 (Minitab Inc., State College, PA). The relationship between Psoriasin expression and tumour grade, TNM staging and nodal status was assessed by Mann–Whitney U test. The error bars shown in the graphs represent the STDEV. Survival was analyzed using Kaplan-Meier survival analysis. Differences were considered statistically significant at p < 0.05.
The expression of Psoriasin mRNA and protein in NSCLC tissues
Psoriasin transcript expression was examined in the lung specimens of 83 NSCLC patients using real-time quantitative PCR (Table
To assess the expression pattern of Psoriasin at the protein level, we performed immunohistochemical analysis of Psoriasin in the paired human NSCLC and normal tissue sections, using a specific anti-Psoriasin monoclonal antibody (n = 16). Psoriasin was almost absent from normal tissues and adenocarcinoma tumours. However, it was interesting to note that squamous carcinoma tissues had a highly positive staining of Psoriasin, mostly in the cytoplasmic region of the tumour cells (Figure
Figure 1
Increased expression of Psoriasin in human lung cancer
Increased expression of Psoriasin in human lung cancer.A, Expression of Psoriasin in squamous carcinoma (A1 to A3) and paired background tissues (A5-A7). Staining of Psoriasin in tumour cells is indicated by arrows. A4 and A8 are matched HE staining for the squamous carcinoma specimen and background tissue. A9 is the negative control of IHC using the secondary antibody alone. B, Psoriasin expression and overall survival of lung cancer.
The association of Psoriasin expression with clinical and histopathological features of NSCLC
The relation of Psoriasin expression to specific pathological status was assessed in the present study. In comparison with its expression in adenocarcinoma tissues, higher levels of Psoriasin transcripts were seen in the squamous carcinoma tissues (p = 0.035). The patients who were former or current smokers had a higher Psoriasin expression compared with the patients who did not smoke at all (p=0.0372).
The relationships between Psoriasin expression and clinical TNM staging and Lymph node status were also analyzed. Statistical analysis showed no significant difference among different groups (Table
Creation of sublines of lung cancer cells with psoriasin over-expression and knockdown
A panel of NSCLC cancer cell lines was examined for the presence of Psoriasin using RT-PCR. Psoriasin transcript was detectable in A549 cell lines, but not expressed in the SK-MES-1 cell lines (Figure
Figure 2
Knockdown and forcing expression of Psoriasin in NSCLC cells
Knockdown and forcing expression of Psoriasin in NSCLC cells.A, Secondary structure of Psoriason mRNA which was used to design anti-Psoriasin ribozymes. B, Establishment of SK-MES-1 cells for expressing Psoriasin and A549 cells for Psoriasin knockdown were verified using RT-PCR.
Effects of Psoriasin over-expression and knockdown on
We first determined the effect of Psoriasin over-expression on
Figure 3
Influences on
Influences on
Impact on
We further examined the influence of Psoriasin on the adhesive nature of these NSCLC cells. Over-expressing Psoriasin in SK-MES-1 significantly reduced the adhesive properties compared to the control groups (Figure
Figure 4
Involvement of Focal Adhesion Kinase (FAK) in adhesion of NSCLC cells affected by Psoriasin
Involvement of Focal Adhesion Kinase (FAK) in adhesion of NSCLC cells affected by Psoriasin.A, An increased phosphorylation of FAK was seen in A549 cells after knockdown of Psoriasin, while no obvious effect was seen in the SK PsoExp cells. B, Addition of 200nM FAK inhibitor diminished the effect of Psoriasin knockdown on adhesion of A549 cells. * indicates p<0.01 v.s. controls.
Effects of Psoriasin manipulation on
Over-expression of Psoriasin in SK-MES-1 resulted in a marked elevation of invasion (Figure
Figure 5
Effect of Psoriasin knockdown and over-expression on invasion and migration of NSCLC cells
Effect of Psoriasin knockdown and over-expression on invasion and migration of NSCLC cells.A, Invasion was enhanced in SK-MES-1 PsoExp cells, p=0.017 compared to SK-MES-1 PEF control cells. B, A549 PsoRib showed a reduction of invasion, p=0.004 compared to A549 PEF control. C and D, There was no change of migration seen in cells of both Psoriasin over-expression and knockdown in comparison with the respective controls.
Effects of Psoriasin over-expression or knockdown on
Psoriasin has been considered to be expressed in a cell type or tissue specific manner. S100A7 is over-expressed in hyperproliferative skin disease-psoriasis
The study further demonstrates that over-expression of Psoriasin is linked to the elevation of growth, invasion and motility of NSCLC cells
The SK-MES-1 cells did exhibit an increased invasion without obvious change in the p-FAK. In our recent study of Psoriasin in prostate cancer cells, matrix metalloproteinases (MMPs) have been indicated in the effect on invasion of cancer cells by Psoriasin
Perhaps the most important observation seen in the present study is the association between the higher levels of Psoriasin transcripts and poor prognosis. These data clearly indicate that Psoriasin is a promoting factor in the disease progression of NSCLC and can be utilised as a potential prognostic indicator which needs to be further investigated in a larger cohort. Selective expression of Psoriasin has been shown in certain types of lung cancer, such as squamous cell carcinomas and large cell carcinomas, but its expression appears to be lower or absent from adenocarcinomas and small cell carcinomas
Taken together, the expression of Psoriasin is increased in lung squamous carcinoma compared with normal lung tissues and lung adenocarcinoma. The elevated expression is associated with poorer overall survival. Psoriasin is involved in the regulation of growth and invasion of NSCLC cells, and its expression is inversely associated with cell adhesion. These results indicate a prognostic and therapeutic potential of Psoriasin in lung cancer.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
MH and LY contributed equally to the study design, experimental work, data analysis and preparation of the manuscript. XZ and WGJ contributed to the study design, data analysis and manuscript preparation. All the authors read and approved the manuscript.
Dr Mu Hu is a recipient of Cardiff University China Medical Scholarship. We wish to thank the Albert Hung Foundation and Cancer Research Wales for supporting our study.
A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies
Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin
Refined mapping of the psoriasin gene S100A7 to chromosome 1cen-q21
The S100 family of EF-hand calcium-binding proteins: functions and pathology
Differential expression of psoriasin messenger RNA between in situ and invasive human breast carcinoma
Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer
Psoriasin (S100A7) up-regulation in oral squamous cell carcinoma and its relation to clinicopathologic features
S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation
The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer
Psoriasin (S100A7) associates with integrin beta6 subunit and is required for alphavbeta6-dependent carcinoma cell invasion
Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain
Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells
A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells
Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid
Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells
Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer
A small proline-rich protein, spr1: specific marker for squamous lung carcinoma
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome
Thyroid transcription factor-1 amplification and expressions in lung adenocarcinoma tissues and pleural effusions predict patient survival and prognosis
Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond
Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas
Psoriasin (S100A7) promotes migration of a squamous carcinoma cell line
Psoriasin expression in mammary epithelial cells in vitro and in vivo
Endogenous bone morphogenetic protein-7 controls the motility of prostate cancer cells through regulation of bone morphogenetic protein antagonists
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells
Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation
Pre-publication history
The pre-publication history for this paper can be accessed here:


text: To get from San Benedetto del Tronto to Viterbo by train you can catch one of the 6 trains that everyday travel between these two cities. The first train to Viterbo leaves from San Benedetto del Tronto at 07:08 and the last train departs at 16:48. If you choose a local train the trip lasts on average 06:05 hours. For your trip from San Benedetto del Tronto to Viterbo by train you can choose to leave from one of San Benedetto del Tronto main stations: Porto D'Ascoli On Wanderio you can compare all schedules, fares and railway companies to Viterbo and book the best itinerary starting from San Benedetto del Tronto.


text: Marcus® Hotels & Resorts, a division of The Marcus Corporation (NYSE: MCS), today announced that Paul Ohm has been appointed general manager of the AAA Four-Diamond Pfister® Hotel in Milwaukee, Wis. Ohm has more than 25 years of experience in the hospitality industry and previously served as general manager of the Fairmont Newport Beach, a 450-room luxury hotel in southern California. Ohm will be responsible for overseeing the general operations of the 307-room hotel, as well as the upcoming renovations of the hotel's 176 tower guest rooms slated to begin in fall 2013. Ohm joins Marcus Hotels & Resorts with a strong background in hospitality. He began his career with the Hyatt Regency Columbus in food and beverage, and served in various positions with Hyatt Hotels in locations including Chicago, San Francisco and Maui. In 2000, Ohm joined Starwood Hotels & Resorts as the director of food and beverage for the Kapalua Bay Hotel in Maui, Hawaii. In 2005, he took the role of director of operations for The Fairmont Washington D.C. hotel. He also served as an opening team member for new hotels while at Fairmont, which included the re-branding of the Hotel Heliopolis in Cairo, Egypt to a Fairmont hotel. "We are thrilled to welcome Paul to Marcus Hotels & Resorts as general manager of The Pfister Hotel. As The Pfister celebrates its 120 th anniversary this fall, Paul's extensive experience in hotel management and operations makes him the ideal candidate to lead this prestigious property and continue its legacy of gracious service and tradition," said Kirk A. Rose, president of Marcus Hotels & Resorts. "I am very excited to join Marcus Hotels & Resorts as the general manager of the company's flagship property," said Ohm. "It is an honor to manage this historic landmark and work in a hotel that still cherishes the core values of hospitality. I look forward to being a part of the Pfister's unique offerings including its award-winning Artist in Residence and Narrator in Residence programs, and continuing to provide memorable and unforgettable experiences to our guests."


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K.S.V. Lodge
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- About Hotel
- Reviews
About K.S.V. Lodge
K.S.V. Lodge a guest house is located opposite Anna Statue, Pondicherry. Pondicherry is one of the most popular tourist destinations in South India.Though very small, Pondicherry was the largest French colony in India and the city has a long and interesting history of trade and war. Hotel proffers front desk as well as room service along with parking facility around the hotel. Each room has its own individual television for entertainment purpose. The most popular tourist destinations are the four beaches in Pondicherry, which are Promenade Beach (also known locally as the Rocky Beach), Paradise Beach, The Auroville Beach and Serenity Beach. There are a number of old and large churches in Pondicherry. Guest can also visit the Botanical Gardens which is located at the south of the New Bus Stand. Arulmigu Manakula Vinayagar Devasthanam on Manakula Vinayagar Street is a famous Hindu temple, which houses Lord Ganesha.
Hotel Amenities
- Room Service
- Parking
- Front Desk
- Television-Room


text: Hey ya'll, My name is Paul and I am a landscape lighting designer/installer/technician. I started as an electrician in an unincorperated area of central Texas. More and more guys were moving to this area and working as electricians because no licenses were needed. This meant that prices were falling and work was getting thin. I had a client that wanted me to do a small lighting project in his back yard. It was a small landscape area with a water feature. I told him, I'd give it a shot. So I did the project and it turned out quite well. His neighbors seemed to like it as well. Well, after doing several small projects I decided to pursue the specialization of low voltage landscape lighting. I studied, read, and learned the tricks of the trade. Now, that is all I do. You can see alot of my work on my web site or just check the "landscape lighting forum on this site. So, now I have told my little story.


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Sterling Silver
Celtic Triquetra Pendant
Peter Stone's Celtic Triquetra Pendant of Sterling Silver. Measures 1 1/2 inches, 3.8 cm.
Please Note: Photo is enlarged to show detail.
Peter Stone - the world's leading manufacturer of fine sterling silver Wicca and Pagan jewelry - has created your Triquetra Pendant for your Celtic Jewelry Collection.
Meticulously crafted from fine sterling silver, the Triquetra Pendant is an enchanting celebration of these iconic Wiccan symbols.


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Policy paper
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Piret Collection Clothing Designer
KimLandersModel Female San Diego, California, US
Mayhem # 2369135
About MeHey everyone! I'm Kim. I'm fairly new to modeling but I'd like to continue working as a model. I have a pretty open schedule and am open to a lot of ideas so message me and we'll see if we can work something out!
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