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A top-quality baitcaster fishing rod and reel combo starts here with the Shimano Curado baitcaster Fishing reel married up with the Shimano raider Barra mauler baitcaster fishing Rod.
This fantastic fishing combo will provide those who love baitcaster's a quality setup able to tackle species up in the Australia's top end such as barramundi and Saratoga.
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♦ Model - Shimano Curado 7.2:1 gear ratio Baitcaster Reel
♦ High Efficiency Gearing (HEG)
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♦ Monofilament line capacity 8lb/180 yards 10lb/155 yards or 14lb/110 yards
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Recommended target fish species – barramundi, cod, saratoga, mangrove jack, flathead, mulloway, queenfish
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♦ A lightweight outfit with the ability to pull in some large fish - this is one durable baitcaster combo.
♦ The fishing rod supplied in this bait casting outfit is a two-piece fishing rod which means you can transport this fishing rod with ease with its broken down length of around 92 cm a piece.
Let's put this plain and simple, if you're after a bait casting fishing set up to target Fish up in the northern areas of Australia such as Saratoga barramundi mangrove Jack large flathead Mulloway and queenfish and you are also looking for a quality outfit that won't let you down and is affordable. Then the Shimano Curado and raider Barra mauler baitcaster fishing combo should be your choice.


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Warning: By law we cannot sell this product to anyone under 18, by placing an order with us you are confirming that you are over the age of 18.
Clix Multi-Purpose Whistle
This is a specialist veterinary product. We will ask you a simple set of questions to confirm that you are buying the correct medicine for your pet and know how to use it safely
Order by 3pm for Express Courier Delivery Some of the items we sell are a bit too bulky to fit on our delivery vans so we offer our customers Next Day Delivery via courier. Deliveries are made from 8am - 8pm Monday to Saturday and 9am - 5pm on Sundays. Your delivery slot will only be confirmed once your order has been placed.
The Clix Multi Purpose Whistle is a good all-round whistle for both the pet dog owner and professional trainer. Made from tough steel, yet still a lightweight design which provides a clear, strong sound. Whistles are ideal for recall, distance training and control and a training guide is included.

subset: commoncrawl


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Gay emo boys sex in chair Andy Kay has shot, directed and starred in
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How To Make a Ke$ha Halloween Costume
Do you want to dress up as your favorite singer for Halloween? This tutorial shows you how to dress up like Ke$ha for Halloween. The Kesha costume is very easy to put together and only requires a little bit of makeup and clothing to put together. Be sure not to get any glitter in your eye!


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Brazilian Heaven - Alberto Fuentes & Pascoal Coelho
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Question about Refrigerators
I have moved the switch to off but the ice bucket still overflowes. There is no swing arm like the old days. What tells the ice maker to stop making ice?
What can I do th solve this problem?
Posted by starflight on
I have the same problem and mine is a roper side by side model number rs22aqxmq00. It has the lever but when the arm goes up it still makes ice.
You didn't state what make and model fridge you have. But most newer units now use an optical eye system, and when the ice blocks the eye's beam it stops making ice. If you've turned the switch to off and it still makes ice, then you need the unit serviced.
Hope that helps...
Posted on Apr 04, 2008
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Only dickheads would do this. So I guess it will be harder to download anime even off fansub websites. IRC is the safest way to go I guess.
They should learn that piracy can never be stopped and that they should only go after bootleggers and uploaders. It would be harder to possibly even get the One Piece manga.


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Do you yearn for more, but can't quite put your finger on what that is? Do you strive for higher income, but at the same time sense there's more to success than making lots of money? Do you long to pursue your purpose in a meaningful and rewarding way? Even though you've already achieved a great deal, do you deeply desire, definitely deserve, and fully expect to reap even greater financial rewards--and want to ensure you handle those financial rewards knowledgeably and responsibly? Sacred Success is a groundbreaking paradigm shift that shows women a better way to achieve wealth and power: on your own terms. In her work with countless powerful, successful women over the last twenty years, bestselling author and financial educator Barbara Stanny found that most women's problems with money have little to do with money itself, but rather their fear of or ambivalence toward power. Instead of pushing women to pursue financial success in the traditional fashion, Sacred Success seeks to redefine power from a feminine perspective. You can be financially successful without sacrificing your soul or compromising your values.
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|gebundene Ausgabe
|BenBella Books
|Maße (L/B/H)
|216/149/25 mm


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Newgate Pantry Wall Clock (Clockwork Grey)
The Newgate Pantry Wall Clock is just what you need if you're looking to jazz up your kitchen space. Made with a cool grey circle frame and some neat and bright neon yellow clock hands, it's easy to spot the time when you're busy cooking up a delicious meal inside your kitchen.
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If you're feeling generous though, this wall clock would also make a lovely present. Give it to your sister or a friend who might appreciate it. They will benefit from its cheerful face each day.
Newgate Pantry Wall Clock - Clockwork Grey Measurements:
Materials Used: Acrylic (rubber finish), glass and metal
Height: 23.3 cm
Width: 23.3 cm
Diameter: 7.2 cm
Product information
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- Wall clocks
- 693115618279
- Newgate Clocks
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This item is sold and dispatched directly by Red Candy.
|Delivery cost
|Mainland UK - standard delivery
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Red Candy is dedicated to the celebration of red home furnishings and modern interior accessories. More about Red Candy...
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Vogue 8820; ©1956; ONE PIECE DRESS. Slim six-gored skirt joins the bodice at waist-line. High and low front neck-line. Long scarf cut in one with left side of bodice front. Scarf may be worn various ways. Long fitted and three quarter length sleeves.
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Fancywork Bust 46 Uncut
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Mobile Wireless Middleware, Operating Systems and Applications - Workshops: Mobilware 2009 Workshops, Berlin, Germany, April 28-29, 2009, Revised and Telecommunications Engineering) by Cristian Hesselman
English | 2009 | ISBN: 364203568X | 163 Pages | PDF | 3 MB
English | 2009 | ISBN: 364203568X | 163 Pages | PDF | 3 MB
Software systems for wireless and mobile communications are a key component in pervasive computing and are crucial for the materialization of easy-to-use
and intel- gent services that people can use ubiquitously. As indicated by its acronym (MOBILe Wireless MiddleWARE, Operating Systems, and Applications), these are the type of systems that form the topic of the MOBILWARE conferencing series. In particular, the goal of MOBILWARE is to provide a forum for researchers and practitioners to disseminate and discuss recent advances in software systems for wireless and mobile communications, ranging from work on communication middleware and operating systems to networking protocols and applications. For its second edition, held in Berlin in April 2009, the MOBILWARE Organizing Committee decided to add a full day of workshops on topics related to the main c- ference. Our goals were threefold: 1. Put together a high-quality workshop program consisting of a few focused wo- shops that would provide ample time for discussion, thus enabling presenters to quickly advance their work and workshop attendees to quickly get an idea of - going work in selected research areas. 2. Provide a more complete picture of ongoing work by not only including technical workshops, but also workshops on business and user aspects. We expected that this multi-viewpoint approach would be an added value as technology, business m- els, and user experiences are usually interrelated. 3. Create a breeding ground for submissions for MOBILWARE 2010 and beyond.
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Begin New Search
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Heather Hawkins Rehn
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I have been researching my ancestors since 2005 and joined Find-A-Grave in June 2012. Studying my family history is a very interesting hobby! Although I live overseas, whenever I visit the USA I enjoy visiting cemeteries and taking pictures of grave markers & tombstones of my ancestors & their extended families. Most of my ancestors lived in North Carolina, South Carolina, or Georgia. I found that I have some information and pictures of graves that have not been posted yet. So, I decided to join Find-A-Grave and share what I can. -- And, I'd love to meet some 'living relatives' in the process. =)
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Vicki Ledbetter
Re:William and Mae Jones
I have found the graves and stones for this couple. However, they are grown over with grass and clippings. I hope to return soon to trim around the foot stones to take picture.
Added by
Vicki Ledbetter
on Mar 18, 2017 9:44 PM
Bulldog Fan
RE: Joseph Luther Sullivan
You're welcome, Heather. The gravestone was not difficult to find. Regards from Bulldog Fan
Added by
Bulldog Fan
on May 12, 2016 10:42 AM
Hal Stewart
RE: Estellar Matthews Whittington
Not that I could find a record of in the book I was using. I will double check when I get back to town. I took pictures of all the marked stones there. There were only three as I remember, I will find a contact with the city when I get back because they actually manage the cemetery and see if they have a better record than I was using.
You friendly neighborhood graver
Added by
Hal Stewart
on Feb 24, 2016 11:26 PM
Daniel Moran
Ms. Rehn: Are you seeking a photograph of this Mr. Sullivan at Owl Rock Methodist Church? I've walked through that cemetery a few times as that I work but about two miles from there.
Send me a message and let me know what you need. I may be able to get over there and snap a couple photographs. Its a small cemetery, and certainly an old one.
Added by
Daniel Moran
on Jan 19, 2016 6:58 PM
Casey Bridges
RE: Wm Moten & Nellie Gillespie
Your Welcome
Added by
Casey Bridges
on Jun 28, 2015 12:00 PM
Sullivan, Alberta
If the photo posted is not to your satisfactory, let me know and I will remove it.
Take care,
Added by
on Jun 26, 2015 2:17 PM
Love in Family
I searched the entire cemetery, photographing each stone and monument and could not locate a marker bearing Carrie's name, however it is reasonable to think that she is resting to the left of her husband as shown in this photograph in an unmarked grave beneath a weathered slab.
I wish this could be the craved in stone marker you were seeking. If you would like the photo removed I would be happy to do so, for you. Happy hunting... Bren
Added by
Love in Family
on May 27, 2015 6:46 PM
Loree Beacham
RE: Joseph Lee & Mattie Kate BOLAND
You are very welcome.
Added by
Loree Beacham
on Apr 02, 2015 8:14 AM
Kathy Riggio
RE: Thank you!
Oh..It is High Shoals Cemetery
Added by
Kathy Riggio
on Jan 24, 2015 12:43 PM
Kathy Riggio
Thank you!
Well, my baby brother , grandmom and grandpop are buried at this churchyard. I found their ID numbers on line , however I do not have any grave pictures. Of special interest is my baby brother. My father told me how he was carelessly handled by my mother's doctor back in 1944 . The doctor literally broke the baby's neck. He died. My mother was distraught to say the least. She was a nurse and my father said she was adamant in never having children again. Well, 4 years later , my brother was born, 11 years later ..ME! So my baby brother is Infant Riggio. Oct 7 1944. I have a very old black and white photo of his grave. It had a cement lamb on it. Curious what it looks like today. Can you be of any help for a picture?
Thanks so much !
Added by
Kathy Riggio
on Jan 23, 2015 3:24 PM
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Vogue 7362; ca. 1968; One piece dress. Slightly fitted slightly A-line dress with mock front closing has button trim. Shaped neckline. Full length or short sleeves, or sleeveless. Purchased scarf.
Featured in Vogue Pattern Book December 1968/January 1969
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|Job Title
|Schools Projects Finance Officer - 6 month FTC - £25-32k - EXPIRED
|Contract Type
|London, London
|£25000 - £32000 per annum
|Job Published
|17 Apr 2015
|Contact Name
|TPP Finance
|Contact Email
A leading school's trust with a network of academy schools across the UK is seeking a Project Finance Officer for a 6 month fixed term contract.
The role will involve doing monthly management accounts and reporting for new schools about to enter the trust's network. The role is based in London but the schools are based in Birmingham, so occasional travel will be required. The role will involve visiting the schools and advising and implementing the trust's standard accounting practices, and bringing the new schools 'up to scratch' financially.
This role would suit a part or fully-qualifed accountant with experience and understanding of academic/schools finance systems. Applicants should have strong understanding of charities SORP & be technically competent in a variety of different accounting systems. Excellent written and verbal communication skills are also a prerequisite.
TPP is committed to equal opportunities and actively encourages applications from all sectors of the community. We shortlist based on competencies and not on race, religion, sex, physical or mental disability, or age.


text:
IN THE NATION; Killings And Control
By Tom Wicker
Published: October 24, 1989
Should the C.I.A. be allowed greater latitude in overthrowing foreign governments, even when such an attempt might lead to the death of that government's leader?
At first glance, the controversy on this issue between Congress and the Bush Administration seems silly and demeaning. Silly, because any attempted coup carries the risk of violence slipping out of control, rules or no rules; demeaning, because such open discussion of killings and coups belies the rule of law by which this nation claims to govern itself.
A closer look suggests, however, that this unseemly dispute masks a deeper issue: Who controls U.S. intelligence?
An order barring political assassination that was adopted by President Ford and strengthened by President Carter has been interpreted by the Congressional intelligence committees to rule out coup attempts in which a foreign leader is likely to be killed. David Boren, the Democratic chairman of the Senate Intelligence Committee, says that interpretation was accepted in writing by the Reagan Administration.
No one has contended seriously that the limit thus imposed on United States participation in coup attempts caused the failure of the recent effort to overthrow Manuel Noriega in Panama - though Secretary of Defense Dick Cheney has said it inhibited U.S. willingness to open communications with the plotters. But the Bush Administration suffered Congressional criticism for the failure; now the Administration is demanding greater latitude to aid future coups, suggesting an effort to point the fin-ger back at Congress.
Senator Boren has invited Mr. Bush to submit proposed changes in the interpretation of the executive order -clearly suggesting Congressional primacy. Thus the controversy reflects an unsettled question dating back to the Church committee hearings on C.I.A. activities in the 1970's. Will the Administration or Congress, as a practical fact, control the guidelines under which intelligence operations can be carried out - and thus, to a large extent, the operations themselves?
Also involved is the role and responsibility of the Director of Central Intelligence. William Webster assumed that office in the littered wake of the activist William Casey and the Iran-contra scandal, and has made a special effort to rebuild relations with Congress. Senator Boren has become perhaps Mr. Webster's strongest supporter.
Recently, however, unnamed senior officials of the Bush Administration severely - if not very courageously - attacked Mr. Webster in statements leaked to The Washington Post. He was considered too close to Congress, they said, too lax in management, not well enough informed, not sufficiently active in advising the President.
''There is some feeling here that Webster does not remember who he works for,'' said one anonymous source. ''He works for the President.''
The unintended result of that comment might be to raise in Congressional minds another unresolved question: a fixed, legislated, 6- or 10-year term for the Director, to remove him (perhaps someday her) from the ranks of political appointees. That would be in many ways desirable, but surely would further lessen a President's control of intelligence operations and perhaps extend Congressional influence.
Predictably, the back-stab attack on Mr. Webster elicited a ringing defense from the President - himself a former C.I.A. Director - which may or may not prove genuine or lasting. Just as predictably, Senator Boren also rallied to the Director. At the least, however, the episode suggests dissatisfaction with Mr. Webster by some White House officials - not necessarily excluding the President - and another source of tension between them and Congress over the control of intelligence.
Ironically, the Director's self-restricted participation in policy-making appears to be part of his White House problem. By his own admission, Mr. Webster sometimes leaves the room when Administration discussions reach the policy stage. That's a welcome change from Casey-style advocacy that sometimes shaped intelligence to fit policy; but it suggests that Mr. Webster may have limited too sharply the Director's legitimate responsibility.
Surely he should take part in policy discussions, at least to argue against schemes that risk more than they promise, or wrongly interpret intelligence, or if only to have firsthand knowledge of how policy decisions were reached.


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Look simply awestruck at a party or office party by choosing this Red Studio Dress. A dazzling look can easily be achieved in this attire if paired with stilettos and a long neckpiece. The bright hue of this lovely dress is appealing and even brings you in the limelight. Not only it adds a dash of sophistication to your personality, but its full sleeves even provide you comfort in the winter season. So, invest in it soon and look fashionable.
- Women's fashion dress made with knit cotton
- Pockets at front
- Full sleeves
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- Unlined
- Cotton Jersey
- Stretch
- Knitted
Model Statistics: Model wears size XS, Height: 5'8", 173 cm
Length: MiniNote: The increase in price for plus sizes is due to an increase in material consumption


text:
|Antoine Thompson
Thompson speaking to reporters in 2020
|46th President of the United States
|In Office:
January 20, 2021 - January 20, 2025
|Vice President:
|Eric Massa
|Preceded by:
|Tim Ashe
|Succeded by:
|Lionel Rivera
|March 1, 1970
Buffalo, New York
|May 31, 2071 (age 101)
Rochester, West New York
|Political party:
|Merle Thompson
|West New York
Antoine M Thompson (March 1, 1970 – May 31, 2071) was an American politician who was a former New York State Senator, US Congressman and was elected President of the United States as a Democrat from New York in 2020. Antoine Thompson became the first African-American President elected succeeding the youngest president. During Thompson's term as President New York was split into 2 states, West New York and New York. Thompson also inherited the "Second Great Depression" and massive inflation. As president he introduced a new amendment to the constitution that would bring back income tax, a proposed solution to the Second Great Depression. It wasn't, however, passed in the Senate, therefore the depression continued. Another issue President Thompson faced was the Venezuelan-American War fought in the southern Caribbean sea near Trinidad and Tobago. The war helped improve the economy slightly as it created jobs in manufacturing. The war ended in December 2024, however and the economy dipped into a deeper depression as Thompson left office, leaving the economic crisis in the hands of Lionel Rivera. After Thompson left office he moved to Rochester, the capital of the new state of West New York (which he helped create.) In 2042 he released an autobiography entitled I Dream of Liberty which sold 65 million copies electronically, and 24 million copies on paper. He gave his last interview in 2056 for Fox.news in which he commented on his opinion of President Kennedy and how well of a job he was doing in comparison to Thompson. Antoine died on May 31, 2071 in his home in Rochester at the age of 101, he was survived by his daughter Anne.


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Team Jerseys
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William Shakespeare's Star Wars
Format: Paperback Author: Ian Doescher
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A retelling of George Lucas' epic Star Wars in the style of the immortal Bard of Avon. It is the saga of a wise (Jedi) knight and an evil (Sith) lord, of a beautiful princess held captive and a young hero coming of age.
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You have nothing in your tote.
This RVLT long sleeve will add visual interest to casual ensembles. Adorned with a striped melange design, this soft cotton crew neck is cut with a curved hemline for an urban cool look. Pair it with faded grey jeans for smart style that's as effortless as rolling out of bed.
This Style from RVLT is also available in Other Colors.
Also available in store at Roadtrip.
100% Cotton
Machine Washable
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Yup, I heard you all loud and clear yesterday! Here they are!
The preorder ends November 29th! Thanks everyone! Seriously, thank you =)
Could one order as a pair to either share or merc it up?
You definitely could do that!
Still waiting on bacon!! Where is the bacon shirts??!!!!! I DEMAND THEM!
Would these be shipped in time for Christmas perchance?
also would like to know!
They will definitely make it in time for domestic shipping.
International shipping is weird because even though I can get it in the mail before the posted USPS deadline, delays and such will most likely make it not arrive on time =(
Invisible Bread pajama pants, Justin. I need them.
I just wear invisible pajama pants. The public doesn't like this though.
Can you make these available in women's shirts as well?
No women's shirts in this current printing run, but I'll see what I can do for the next shirt printing!


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Turbulence Model and Meshing Advice
I have a complex bluff body with cavities, gaps, and fins protruding from the body. I was asked to get the unsteady frequencies coming off these different features at compressible subsonic speeds (about Mach .5, and ignoring Fluid-Structure-Interaction, which we simply can't handle here).
I'm assuming this will get too complex for a realizable k-ep model, but can an RSM handle this, or do I have to go with an LES model? Also, as far as meshing goes, can I get away with using y+ values of around 30, or do I have to bring the mesh down to y+ value of around 1?
Any other advice is greatly appreciated as well.
Thanks, Jason
Re: Turbulence Model and Meshing Advice
I say that RSM will do the job respectably, even with y+=30, of course taking care to have a REAL B-L mesh (6-7 or better 10 layers, with lowest skewness possible), at least 2nd order discretisation and well resolved wakes. The only thing I'm worried about is the actual frequencies values you will obtain with RSM...
LES (or better DES in your case) will certainly do a much better job. One thing: computational effort with DES might be almost equal to a ordinary k-e unsteady calculation(I say this because I oftenly encountered this situation when doing my own calculations)!
Beware: DES comp. effort = k-e unsteady comp. effort means same CPU time for a time step! But that's it! The "problem" with DES is that you'll absolutely need more and sometimes smaller time steps to really converge the solution.
Anyway, if precision is what you're looking for, take DES. My advice.
Good luck, Razvan
|All times are GMT -4. The time now is 09:42.


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If you are conducting some Coleman family history research then you can view the Coleman coat of arms and the name meaning and origin of the name as well as the meaning of symbols below. This is a great place to start when tracing your genealogy and Coleman surname history and will help you answer the question 'what is the meaning of my name?'
The name Coleman in Ireland is
derived from the native Gaelic
O'Colmain Sept, taken from a
word meaning 'dove'. This Sept
was based in County Sligo.
Another Gaelic Sept who adopted
Coleman as the anglicized version of
their name was the O'Clumhain Sept
of County Cork.
Colman and Cluvane are variants.
A Sept or Clan is a collective term describing a group of persons whose immediate ancestors had a common surname and all inhabited the same lands.
|Argent/White or Silver
|Denotes Peace and Sincerity.
|Denotes Constancy and sometimes Grief.
|Often representing Faith or Christian beliefs, possibly relating to the Crusades
|Mullet/Star of Five Points
|Denotes Virtue, Learning, and Piety.
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Online Registration for Winterfest 2017 is now live!
A deposit of one hundred dollars secures a place on the trip of your choice. We accept Visa, Mastercard, Discover, e-checks or cash. The final payment will be required by Friday, December 16. Visit, email, or call the GRAB office with any questions.
Important Forms
Packing List: Cumberland Island Backpacking
Packing List: White Mountains, NH
Packing List: Suwannee River Kayaking


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By Ken Thomas, Associated Press Writer
WASHINGTON The average fuel efficiency of the fleet of new cars and trucks rose only slightly in 2008, but the government said Friday an increase in the sales of smaller vehicles due to high gas prices could push the numbers higher.
The Environmental Protection Agency reported that the average performance of new, 2008 model cars and trucks was 20.8 miles per gallon in 2008, up 0.2 mpg compared to 2007 model year vehicles a year ago, and a 1.5 mpg increase since 2004.
The estimates, which the agency uses on vehicle window stickers on dealer lots, are based on a combination of pre-sale road tests and projections of likely sales of the new model vehicles. But with people buying smaller, more fuel efficient vehicles -- and fewer SUVs and pickups -- those fleet-wide projections were likely to be off the mark, the EPA acknowledged.
The EPA said it was "extremely likely" the 20.8 mpg estimate for 2008 model vehicles is too low.
Honda Motor Co. led the way with a projected 23.6 mpg, followed by Toyota Motor Corp. with 23.4 mpg. Hyundai Motor Co. was third with 22.6 mpg.
Nissan Motor Co. and BMW AG had estimated fuel economies of 21.2 mpg and Volkswagen AG stood at 21 mpg.
Domestic automakers, which have sold a higher mix of trucks and SUVs, were led by General Motors Corp. with an estimated 19.6 mpg. Ford Motor Co. had an estimated 19 mpg and Chrysler LLC came in at 18.9 mpg.
Among individual vehicle segments, hybrids such as the Toyota Prius (46.2 mpg combined), Honda Civic Hybrid (42.9 mpg combined), and Ford Escape Hybrid front-wheel drive SUV (31.5 mpg combined) led their peers.
The EPA noted that the estimates were based on 2008 model year sales projections that were made when gas was selling at $2.50 to $3 a gallon, far below the $3.50 a gallon average during the sales period.
During the year, sales of midsize sport utility vehicles, large SUVs and large pickup trucks have fallen about 15 to 25 percent below the auto industry's projections, EPA said.
Fuel-sipping subcompact, compact and midsize cars, meanwhile, have become more popular and vehicles with 4-cylinder engines have gained market share during the span. EPA said the combined factors could lead to higher fuel economy estimates when more sales data is available.
President Bush signed an energy bill last year that requires car makers to meet a fleetwide average of at least 35 miles per gallon by 2020, a 40 percent increase over current standards. Those figures are derived from laboratory testing and the EPA said that average increased to 26 mpg in 2008 compared with 25.7 mpg in 2007.
Environmental groups said the report reflected a lack of good options among many vehicle categories. In the larger truck segments, for example, there was little difference in fuel efficiency among the best performers and the mediocre ones.
"The American people have not had the choice to buy a clean vehicle except for certain sized sedans and the smallest SUVs," said Dan Becker, director of the Safe Climate Campaign for the Center for Auto Safety.
But Charles Territo, a spokesman for the Alliance of Automobile Manufacturers, which represents GM, Toyota, Ford, Chrysler and others, said the report showed the lengthy list of fuel-efficient vehicles on the market.
More than 100 vehicle models offer 30 mpg or better on the highway and they "have become extremely popular recently with the rise in higher gas prices," he said.
Fuel efficiency has become a top selling point at dealerships with the rise in gas prices.
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Guidelines: You share in the USA TODAY community, so please keep your comments smart and civil. Don't attack other readers personally, and keep your language decent. Use the "Report Abuse" button to make a difference. Read more.


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Melbourne derby matches or international fixtures in difficult environments against tough opponents. All bring their own types of pressure, but for Melbourne Victory captain and Socceroo midfielder Mark Milligan, it is all part of the job.
Milligan admits the first of the season's three derbies against the rebranded Melbourne City takes on added piquancy following the seismic changes at the city's "second" club over the past 10 months since its acquisition by English Premier League champion Manchester City.
And he also acknowledges the Socceroos' recent run of poor results as coach Ange Postecoglou tries out new faces ahead of the Asian Cup in Australia next year puts not just the coaching staff but the players under extra, unwelcome scrutiny.
But, says Milligan, the extra attention - be it for high-profile derby fixtures or underperforming international teams - comes with the turf when the big matches roll around.
"It's very exciting, the new enterprise and the first derby of the sort. I don't think their name change will make it any more exciting though [than the clash between the local rivals usually is]," he said.
"They have recruited well and had a decent start. Bringing the seats in [at Etihad Stadium] helps with atmosphere. We will approach it as we did on the weekend [when Victory played a high-profile game against Adelaide United in front of 33,000 fans at Adelaide Oval]. We stuck to our structure. We know we will have a lot of home fans there. We are going to want to go into it and really stamp our style on the match."
While Damien Duff and David Villa have begun the season in slashing style, Milligan said there were no special plans for the two big-name foreign stars.
"Both have started the season really well, so we will have to be aware of them, but they have a totally different side, they are doing things differently to what they did last year.
"We are always made aware of the results since the derby started, but this is a new season and a newish team for both of us."
Victory goes into this game with four points, City two after the opening rounds. Both sides are unbeaten, but Milligan said the league table was rarely a guide when derbies rolled around.
"In the derbies I have played in in the past, that sort of goes out of the window," he said. "Even when we play them and they haven't been in the greatest of form, they seem to play their best football on derby day. The whole derby is about that. You want to do well in it because you want to be the top team in Melbourne.
"We always wanted to be the main club in Melbourne, and I guess it will be a little more satisfying knowing the backing they do have if we can go out there and put in a big performance and get a good result."
Milligan was part of the Socceroos squad that drew with the United Arab Emirates and lost to Qatar in recent friendlies. He knows the critics are sharpening their knives ahead of the Asian Cup, but also realises it is to be expected when results are poor.
"I guess when you do have disappointing results you expect people will analyse and you will come under criticism, not just coaching staff but players as well.
"The boys believe and trust in what Ange [Postecoglou] is trying to do. For a long time so many people were calling for change at the national level with new players to be blooded and get game time, and at the moment that's exactly what's happening. We are doing it while we are on the road, through Europe and Asia, and this is really the only time you can get younger and new players to get good game time.
"We are disappointed in the results, but hopefully, being able to play a number of new players is going to give them more experience and confidence when we come to the big show in January."


text: Steam Vents Printings/Rarity: Card Type: Land — Island Mountain Oracle Text: (: Add or to your mana pool.) As Steam Vents comes into play, you may pay 2 life. If you don't, Steam Vents comes into play tapped. Flavor Text: Crafted with genius, energized with madness. Retrieved from "http://mtg.wikia.com/wiki/Steam_Vents?oldid=68210" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Guildpact Rare Return to Ravnica Zendikar Expeditions Mythic Rare Cards Land Nonbasic Land


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Citation: (2004) Protein Helps Orchestrate Cells' Fluid Uptake. PLoS Biol 2(9): e318. https://doi.org/10.1371/journal.pbio.0020318
Published: August 24, 2004
Copyright: © 2004 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
You are what you eat and drink. Steak can sit in your stomach or orange juice wind through your intestines, but they only become part of your body once they're taken up by your cells. First, foods must be reduced to a soup of proteins, fats, sugars, and so on. But even then, getting these materials into a cell isn't as simple as sticking them in your mouth. For one, there's the membrane enclosing a cell. Simply puncturing a hole in the membrane would spill the cell's contents, harming or killing the cell.
Instead, all eukaryotes—organisms whose cells have nuclei—use a carefully orchestrated process called endocytosis to bring materials into their cells. Eukaryotic cells first form cavities in their cell membrane that surround nearby particles or fluid. These pockets seal shut and bud off into the cell to form small membrane-bound sacs called vesicles.
When taking in fluids, eukaryotic cells use two distinct mechanisms—to take tiny sips or huge gulps. With one process, called pinocytosis, cells continually form small pockets in the cell membrane that enclose small droplets of fluid in vesicles called pinosomes. These newly formed vesicles, called early endosomes, bud off from the membrane and fuse with other early endosomes. In one form of pinocytosis, the vesicles are encaged by a protein called clathrin that tightly constrains their size. These carriers incorporate membrane constituents (for example, growth factors) with very high selectivity. In macropinocytosis, on the other hand, large ruffles in the membrane engulf mass quantities of fluid in vesicles known as macropinosomes.
Beyond taking in nutrients, these processes are essential to the function of many organs—from the brain, where nerve cells receive other cells' chemical signals by pinocytosis, to the kidney, where cells use macropinocytosis to take in waste fluids for processing. Macropinocytosis is also relevant to cancer cells; it has long been known that oncogenes dramatically induce this endocytic process, affecting the signaling status of these cells. But compared with other types of endocytosis, molecular biologists know surprisingly little of the mechanisms behind macropinocytosis. They do know that the Rab5 protein—an enzyme that coordinates a complex network of other proteins, called effectors—is crucial for both pinocytosis and macropinocytosis.
Now, as reported in this issue of PLoS Biology, Marino Zerial and colleagues have found a new protein, which they named Rabankyrin-5, that forms a further link between these two mechanisms for fluid uptake. The protein is necessary for macropinocytosis, and its levels control the rate of this process. In addition, Rabankyrin-5 helps regulate endosome trafficking and coordinates this mechanism with macropinocytosis.
In two commonly used human and mouse cell lines, the researchers found the protein Rabankyrin-5 along with Rab5 on both types of pinosomes, early endosomes and macropinosomes. The early endosomes usually fuse with one another inside the cell, but when the researchers blocked Rabankyrin-5 activity, this fusion fell sharply. Suppressing Rabankyrin-5 activity also stifled macropinocytosis; overexpressing the effector, on the other hand, sent macropinocytosis into overdrive.
The researchers also looked at endocytosis in mouse kidney and canine kidney cell lines. Inside the kidney, fluid-carrying ducts are lined with epithelial cells that take up liquids through their exposed surface. The researchers found Rabankyrin-5 predominately on vesicles at this surface, and as in the other experiments, overexpression of the protein promoted macropinocytosis. Together, these findings suggest Rabankyrin-5 plays a role in regulating this form of fluid uptake and plays a role in kidney function. The discovery of Rabankyrin-5 involvement in macropinocytosis also has implications for other physiological and pathological mechanisms such as the immune system response, defense against pathogens, and hyperactivation of signaling pathways in cancer cells.
Rabankyrin-5 contains various regions that bind other proteins and also lipids found in cell membranes, suggesting the protein plays a mechanical role in forming vesicles. The protein also has regions found on other proteins that are involved in signaling and development, so it may help direct vesicles' traffic within the cell. The protein also has regions characteristic of proteins involved in clathrin-dependent endocytosis, which fits with the researchers' finding that Rabankyrin-5 affects pinocytosis.
All told, Rabankyrin-5 appears to form a bridge between two distinct mechanisms, pinocytosis and macropinocytosis, that cells use to take in fluids. While the details of how Rabankyrin-5 functions are still unclear, these findings give researchers a new handle for grasping how macropinocytosis works and how cells control when and how much they drink in their surroundings.


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Sunday, October 14, 2007
Mea Culpa!
I forgot to link to this week's Grand Rounds! Sorry the link is so late!
It looks like a great edition, and I still wish I'd gotten something written for it. Oh well! Meanwhile, I have four hours before the deadline for this week's edition . . . Ack!
Posted by Susan Palwick at 5:04 PM
Labels: Grand Rounds
Subscribe to: Post Comments (Atom)


text: Tree of Perdition Printings/Rarity: Cost: CMC: 4 Card Type: Creature — Plant Power/Toughness: 0/13 Oracle Text: Defender : Exchange target opponent's life total with Tree of Perdition's toughness. Flavor Text: There will be no absolution. Retrieved from "http://mtg.wikia.com/wiki/Tree_of_Perdition?oldid=67043" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Eldritch Moon Mythic Rare Cards CMC: 4 Black Creature Plant Defender


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