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Bone regeneration: current concepts and future directions
Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumour resection and skeletal abnormalities, or cases in which the regenerative process is compromised, including avascular necrosis, atrophic non-unions and osteoporosis. Currently, there is a plethora of different strategies to augment the impaired or 'insufficient' bone-regeneration process, including the 'gold standard' autologous bone graft, free fibula vascularised graft, allograft implantation, and use of growth factors, osteoconductive scaffolds, osteoprogenitor cells and distraction osteogenesis. Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible, to accelerate the overall regeneration process, or even to address systemic conditions, such as skeletal disorders and osteoporosis.
Bone possesses the intrinsic capacity for regeneration as part of the repair process in response to injury, as well as during skeletal development or continuous remodelling throughout adult life
Current clinical approaches to enhance bone regeneration
For all the aforementioned cases in which the normal process of bone regeneration is either impaired or simply insufficient, there are currently a number of treatment methods available in the surgeon's armamentarium, which can be used either alone or in combination for the enhancement or management of these complex clinical situations, which can often be recalcitrant to treatment, representing a medical and socioeconomic challenge. Standard approaches widely used in clinical practice to stimulate or augment bone regeneration include distraction osteogenesis and bone transport
During distraction osteogenesis and bone transport, bone regeneration is induced between the gradually distracted osseous surfaces. A variety of methods are currently used to treat bone loss or limb-length discrepancies and deformities, including external fixators and the Ilizarov technique
Bone grafting is a commonly performed surgical procedure to augment bone regeneration in a variety of orthopaedic and maxillofacial procedures, with autologous bone being considered as the 'gold standard' bone-grafting material, as it combines all properties required in a bone-graft material: osteoinduction (bone morphogenetic proteins (BMPs) and other growth factors), osteogenesis (osteoprogenitor cells) and osteoconduction (scaffold)
An alternative is allogeneic bone grafting, obtained from human cadavers or living donors, which bypasses the problems associated with harvesting and quantity of graft material. Allogeneic bone is available in many preparations, including demineralised bone matrix (DBM), morcellised and cancellous chips, corticocancellous and cortical grafts, and osteochondral and whole-bone segments, depending on the recipient site requirements. Their biological properties vary, but overall, they possess reduced osteoinductive properties and no cellular component, because donor grafts are devitalised via irradiation or freeze-drying processing
Bone-graft substitutes have also been developed as alternatives to autologous or allogeneic bone grafts. They consist of scaffolds made of synthetic or natural biomaterials that promote the migration, proliferation and differentiation of bone cells for bone regeneration. A wide range of biomaterials and synthetic bone substitutes are currently used as scaffolds, including collagen, hydroxyapatite (HA), β-tricalcium phosphate (β-TCP) and calcium-phosphate cements, and glass ceramics
Limitations of current strategies to enhance bone regeneration
Most of the current strategies for bone regeneration exhibit relatively satisfactory results. However, there are associated drawbacks and limitations to their use and availability, and even controversial reports about their efficacy and cost-effectiveness. Furthermore, at present there are no heterologous or synthetic bone substitutes available that have superior or even the same biological or mechanical properties compared with bone. Therefore, there is a necessity to develop novel treatments as alternatives or adjuncts to the standard methods used for bone regeneration, in an effort to overcome these limitations, which has been a goal for many decades. Even back in the 1950s, Professor Sir Charnley, a pioneer British orthopaedic surgeon, stated that 'practically all classical operations of surgery have now been explored, and unless some revolutionary discovery is made which will put the control of osteogenesis in the surgeon's power, no great advance is likely to come from modification of their detail'
Since then, our understanding of bone regeneration at the cellular and molecular level has advanced enormously, and is still ongoing. New methods for studying this process, such as quantitative three-dimensional microcomputed tomography analyses, finite element modelling, and nanotechnology have been developed to further evaluate the mechanical properties of bone regenerate at the microscopic level. In addition, advances made in cellular and molecular biology have allowed detailed histological analyses,
Figure 1
Male patient 19 years of age with infected non-union after intramedullary nailing of an open tibial fracture
Male patient 19 years of age with infected non-union after intramedullary nailing of an open tibial fracture. (A). Anteroposterior (AP) and lateral X-rays of the tibia illustrating osteolysis (white arrow) secondary to infection. The patient underwent removal of the nail, extensive debridement and a two-staged reconstruction of the bone defect, using the induced membrane technique for bone regeneration (the Masquelet technique). (B) Intraoperative pictures showing: (1) a 60 mm defect of the tibia (black arrow) at the second stage of the procedure; (2) adequate mechanical stability was provided with internal fixation (locking plate) bridging the defect, while the length was maintained (black arrow); (3) maximum biological stimulation was provided using autologous bone graft harvested from the femoral canal (black arrow, right), bone-marrow mesenchymal stem cells (broken arrow, left) and the osteoinductive factor bone morphogenetic protein-7 (centre); (4) the graft was placed to fill the bone defect (black arrow). (C) Intraoperative fluoroscopic images showing the bone defect after fixation. (D) Postoperative AP and lateral X-rays at 3 months, showing the evolution of the bone regeneration process with satisfactory incorporation and mineralisation of the graft (photographs courtesy of PVG).
BMPs and other growth factors
With improved understanding of fracture healing and bone regeneration at the molecular level
Of these molecules, BMPs have been the most extensively studied, as they are potent osteoinductive factors. They induce the mitogenesis of mesenchymal stem cells (MSCs) and other osteoprogenitors, and their differentiation towards osteoblasts. Since the discovery of BMPs, a number of experimental and clinical trials have supported the safety and efficacy of their use as osteoinductive bone-graft substitutes for bone regeneration. With the use of recombinant DNA technology, BMP-2 and BMP-7 have been licensed for clinical use since 2002 and 2001 respectively
Other growth factors besides BMPs that have been implicated during bone regeneration, with different functions in terms of cell proliferation, chemotaxis and angiogenesis, are also being investigated or are currently being used to augment bone repair
'Orthobiologics' and the overall concept to stimulate the local 'biology' by applying growth factors (especially BMPs, because these are the most potent osteoinductive molecules) could be advantageous for bone regeneration or even for acceleration of normal bone healing to reduce the length of fracture treatment. Their clinical use, either alone or combined with bone grafts, is constantly increasing. However, there are several issues about their use, including safety (because of the supraphysiological concentrations of growth factors needed to obtain the desired osteoinductive effects), the high cost of treatment, and more importantly, the potential for ectopic bone formation
Currently BMPs are also being used in bone-tissue engineering, but several issues need to be further examined, such as optimum dosage and provision of a sustained, biologically appropriate concentration at the site of bone regeneration, and the use of a 'cocktail' of other growth factors that have shown significant promising results in preclinical and early clinical investigation
An adequate supply of cells (MSCs and osteoprogenitors) is important for efficient bone regeneration. The current approach of delivering osteogenic cells directly to the regeneration site includes use of bone-marrow aspirate from the iliac crest, which also contains growth factors. It is a minimally invasive procedure to enhance bone repair, and produces satisfactory results
Issues of quantity and alternative sources of MSCs are being extensively investigated. Novel approaches in terms of cell harvesting,
It is fair to say that the role of MSCs in fracture repair is still in its infancy, largely due to a lack of studies into the biology of MSCs
Scaffolds and bone substitutes
Although they lack osteoinductive or osteogenic properties, synthetic bone substitutes and biomaterials are already widely used in clinical practice for osteoconduction. DBM and collagen are biomaterials, used mainly as bone-graft extenders, as they provide minimal structural support
Research is ongoing to improve the mechanical properties and biocompatibility of scaffolds, to promote osteoblast adhesion, growth and differentiation, and t0 allow vascular ingrowth and bone-tissue formation. Improved biodegradable and bioactive three-dimensional porous scaffolds
Tissue engineering
The tissue-engineering approach is a promising strategy added in the field of bone regenerative medicine, which aims to generate new, cell-driven, functional tissues, rather than just to implant non-living scaffolds
Several major technical advances have been achieved in the field of bone-tissue engineering during the past decade, especially with the increased understanding of bone healing at the molecular and cellular level, allowing the conduction of numerous animal studies and of the first pilot clinical studies using tissue-engineered constructs for local bone regeneration. To date, seven human studies have been conducted using culture-expanded, non-genetically modified MSCs for regeneration of bone defects: two studies reporting on long bones and five on maxillofacial conditions
Recently, an animal study has shown the potential for prefabrication of vascularised bioartificial bone grafts
Overall, bone-tissue engineering is in its infancy, and there are many issues of efficacy, safety and cost to be addressed before general clinical application can be achieved. Cultured-expanded cells may have mutations or epigenetic changes that could confer a tumour-forming potential
Gene therapy
Another promising method of growth-factor delivery in the field of bone-tissue engineering is the application of gene therapy
Besides the issues of cost, efficacy and biological safety that need to be answered before this strategy of genetic manipulation is applied in humans, delivery of growth factors, particularly BMPs, using gene therapy for bone regeneration has already produced promising results in animal studies
Mechanical stability and the role of mechanical stimulation in bone regeneration
In addition to the intrinsic potential of bone to regenerate and to the aforementioned methods used to enhance bone regeneration, adequate mechanical stability by various means of stabilisation and use of fixation devices is also an important element for optimal bone repair, especially in challenging cases involving large bone defects or impaired bone healing. The mechanical environment constitutes the fourth factor of the 'diamond concept' of fracture healing, along with osteoconductive scaffolds, growth factors and osteogenic cells, interacting during the repair process
During bone regeneration, intermediate tissues, such as fibrous connective tissue, cartilage and woven bone, precede final bone formation, providing initial mechanical stability and a scaffold for tissue differentiation. The mechanical loading affects the regeneration process, with different stress distribution favouring or inhibiting differentiation of particular tissue phenotypes
The interfragmentary strain concept of Perren has been used to describe the different patterns of bone repair (primary or secondary fracture healing), suggesting that the strain that causes healthy bone to fail is the upper limit that can be tolerated for the regenerating tissue
Mechanical stability is also important for local vascularisation and angiogenesis during bone regeneration. In an i
Finally, the presence of a mechanically stable environment throughout the bone-regeneration process is also essential when additional methods are being used to enhance bone repair
Systemic enhancement of bone regeneration
As an alternative to local augmentation of the bone-regeneration process, the use of systemic agents, including growth hormone (GH)
In addition to the anabolic agents for bone regeneration, current antiresorptive therapies that are already in clinical use for the management of osteoporosis could be used to increase bone-mineral density during bone regeneration and remodelling by reducing bone resorption. Biphosphonates, known to reduce the recruitment and activity of osteoclasts and increase their apoptosis, and strontium ranelate, known to inhibit bone resorption and stimulate bone formation, could be beneficial adjuncts to bone repair by altering bone turnover
Recently, another signalling pathway, the Wnt pathway, was found to play a role in bone regeneration
Another approach for systemic enhancement of bone regeneration is the use of agonists of the prostaglandin receptors EP2 and EP4, which were found to be skeletally anabolic at cortical and cancellous sites. Promising results have been seen in animal models, without adverse effects, and therefore these receptors may represent novel anabolic agents for the treatment of osteoporosis and for augmentation of bone healing
Finally, new treatments for systemic augmentation of bone regeneration may come to light while researchers are trying to elucidate the alterations seen at the cellular and molecular level in conditions with increased bone formation capacity. Fibrodysplasia ossificans progressiva, a rare genetic disorder, is an example of how an abnormal metabolic condition can be viewed as evidence for systemic regeneration of large amounts of bone secondary to alterations within the BMP signalling pathway
There are several clinical conditions that require enhancement of bone regeneration either locally or systemically, and various methods are currently used to augment or accelerate bone repair, depending on the healing potential and the specific requirements of each case. Knowledge of bone biology has vastly expanded with the increased understanding at the molecular level, resulting in development of many new treatment methods, with many others (or improvements to current ones) anticipated in the years to come. However, there are still gaps; in particular, there is still surprisingly little information available about the cellular basis for MSC-mediated fracture repair and bone regeneration
In the future, control of bone regeneration with strategies that mimic the normal cascade of bone formation will offer successful management of conditions requiring enhancement of bone regeneration, and reduce their morbidity and cost in the long term. Research is ongoing within all relevant fields, and it is hoped that many bone-disease processes secondary to trauma, bone resection due to ablative surgery, ageing, and metabolic or genetic skeletal disorders will be successfully treated with novel bone-regeneration protocols that may address both local and systemic enhancement to optimise outcome.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
RD contributed to the literature review and writing. EJ, DMcG and PVG contributed to the writing of specific sections of the manuscript within their main scientific interest, and critically revised the manuscript for important intellectual content. All authors read and have given final approval of the final manuscript.
Bone injury, healing and grafting
The cell and molecular biology of fracture healing
Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing
Does adult fracture repair recapitulate embryonic skeletal formation?
Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures
Limb-lengthening, skeletal reconstruction, and bone transport with the Ilizarov method
Management of segmental defects by the Ilizarov intercalary bone transport method
Bone substitutes: an update
Bone morphogenetic proteins in musculoskeletal medicine
The concept of induced membrane for reconstruction of long bone defects
The effect of low-intensity pulsed ultrasound therapy on time to fracture healing: a meta-analysis
Improved healing response in delayed unions of the tibia with low-intensity pulsed ultrasound: results of a randomized sham-controlled trial
Low-intensity pulsed ultrasound and pulsed electromagnetic field in the treatment of tibial fractures: a systematic review
The monorail method for segment bone transport
The intramedullary skeletal kinetic distractor (ISKD): first clinical results of a new intramedullary nail for lengthening of the femur and tibia
Bone graft materials. An overview of the basic science
Long bone reconstruction with vascularized bone grafts
Femoral head osteonecrosis: Why choose free vascularized fibula grafting
Surgical techniques: how I do it? The reamer/irrigator/aspirator (RIA) system
Comparison of anterior and posterior iliac crest bone graft in terms of harvest-site morbidity and functional outcomes
Physical and monetary costs associated with autogenous bone graft harvesting
Morbidity at bone graft donor sites
Bone-grafting and bone-graft substitutes
Is an impacted morselized graft in a cage an alternative for reconstructing segmental diaphyseal defects?
Management of a long segmental defect at the proximal meta-diaphyseal junction of the tibia using a cylindrical titanium mesh cage
The control of fracture healing and its therapeutic targeting: improving upon nature
Fracture healing: the diamond concept
Current concepts of molecular aspects of bone healing
Medical devices. [
Formulations and delivery vehicles for bone morphogenetic proteins: latest advances and future directions
Growth factors: beyond bone morphogenetic proteins
The role of growth factors and related agents in accelerating fracture healing
The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature
Bone morphogenetic proteins in orthopaedic trauma surgery
Composite glycidyl methacrylated dextran (Dex-GMA)/gelatin nanoparticles for localized protein delivery
Efficacy of minimally invasive techniques for enhancement of fracture healing: evidence today
Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow
Effect of age and sampling site on the chondro-osteogenic potential of rabbit marrow-derived mesenchymal progenitor cells
Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells
Bridging the gap: bone marrow aspiration concentrate reduces autologous bone grafting in osseous defects
Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2
Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential
Cellular strategies for enhancement of fracture repair
The relevance of mesenchymal stem cells in vivo for future orthopaedic strategies aimed at fracture repair
Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months
Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing
Multilineage cells from human adipose tissue: implications for cell-based therapies
Mesenchymal progenitor cells derived from traumatized human muscle
Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?
Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma
Human bone marrow mesenchymal stem cells in vivo
Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells
Large-scale extraction and characterization of CD271+ multipotential stromal cells from trabecular bone in health and osteoarthritis: implications for bone regeneration strategies based on uncultured or minimally cultured multipotential stromal cells
A novel collagen/hydroxyapatite/poly(lactide-co-ε-caprolactone) biodegradable and bioactive 3D porous scaffold for bone regeneration
A conceptually new type of bio-hybrid scaffold for bone regeneration
Injectable nanocrystalline hydroxyapatite paste for bone substitution: in vivo analysis of biocompatibility and vascularization
Bone tissue engineering: state of the art and future trends
Bone tissue engineering: hope vs hype
Mesenchymal stem cells and their future in bone repair
Clinical application of human mesenchymal stromal cells for bone tissue engineering
A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast (Ossron) injection to treat fractures
Tissue engineered ceramic artificial joint--ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis
Prefabrication of vascularized bioartificial bone grafts in vivo for segmental mandibular reconstruction: experimental pilot study in sheep and first clinical application
Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation
Conditions affecting cell seeding onto three-dimensional scaffolds for cellular-based biodegradable implants
Repair of large osteochondral defects with allogeneic cartilaginous aggregates formed from bone marrow-derived cells using RWV bioreactor
Mesenchymal stem cells and gene therapy
Orthopaedic application of gene therapy
Bone morphogenetic proteins and tissue engineering: future directions
Combination of bone tissue engineering and BMP-2 gene transfection promotes bone healing in osteoporotic rats
A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading
Physical and biological aspects of fracture healing with special reference to internal fixation
Effect of mechanical stability on fracture healing--an update
Instability prolongs the chondral phase during bone healing in sheep
The course of bone healing is influenced by the initial shear fixation stability
The effect of mechanical stability on local vascularization and tissue differentiation in callus healing
Initial vascularization and tissue differentiation are influenced by fixation stability
Bone scaffolds: The role of mechanical stability and instrumentation
Growth hormone: does it have a therapeutic role in fracture healing?
Parathyroid hormone as an anabolic skeletal therapy
The safety and efficacy of parathyroid hormone (PTH) as a biological response modifier for the enhancement of bone regeneration
PTH analogues and osteoporotic fractures
European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO): European guidance for the diagnosis and management of osteoporosis in postmenopausal women
The role and efficacy of denosumab in the treatment of osteoporosis: an update
Wnt pathway, an essential role in bone regeneration
The therapeutic potential of the Wnt signaling pathway in bone disorders
Mutations of the noggin (NOG) and of the activin A type I receptor (ACVR1) genes in a series of twenty-seven French fibrodysplasia ossificans progressiva (FOP) patients
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Nanchang Haibo Import and Export Co Ltd
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An Untamed World as Revealed
by Connor Stefanison
Connor Stefanison was born on May 31, 1991 in Burnaby, Canada. He was introduced to the world of photography while indulging his other passion, mountain biking. Since then Connor devoted ample time to better understand the nuances of the craft. And when, less than a year ago, he became the first Canadian to receive the prestigious Eric Hosking Portfolio Award, presented to him in London, he knew he is on the right track. The honour not only granted him instant international recognition but also provided him with motivation to broaden his horizon even further.
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The Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID) is designed to introduce infectious disease researchers to modern methods of statistical analysis and mathematical modeling and to introduce statisticians and mathematical modelers to the statistical and dynamic problems posed by modern infectious disease data.
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News Posts
News posts
May 23-25: Memorial Day at the Museum
by AMNH on
The long weekend is a perfect opportunity to visit the Museum for exhibitions and special events.
Tour the Museum's Big Cats at Spotlight Asia
by AMNH on
Tour the Musem's big cat dioramas as part of Spotlight Asia on Saturday, May 23.
Fabulous Finds at Identification Day
by AMNH on
Many collectors got answers to questions about their curious finds at the Museum's annual Identification Day on May 9.
May 9-10: Amazing Animals, Your Unusual Artifacts and More!
by AMNH on
This Saturday come to the Museum for Identification Day and Celebrate ID Day!
Museum Wins Carnegie Award for Educational Programs
by AMNH on
The award from the Carnegie Corporation includes a generous grant to support the Museum's exemplary educational offerings.


text: I'll be up in Tampa in a few weeks and my friends want to go to a great Chinese Seafood Buffet. I've heard about 2 of them in Tampa: Vari-Asian Crazy Buffet and Todai. Has anyone had any experience with either of these 2 places and if so, which would you recommend. Also, are there other ones around that are better?


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The Actual Reason Why the Ratings for Yankee Broadcasts in 2013 are Down
Apparently, through 28 Yankee games on the YES Network this season, the ratings are down 39% compared to the same time span in 2012. Bob Raissman of the Daily News hypothesized that the main reason for the decline in ratings is the lack of star players, such as Derek Jeter and Alex Rodriguez, in the everyday lineup:
The ratings provide ample evidence that plenty of Yankee fans are not intrigued. They have tuned out.
It's got everything to do with the lack of star power. Throughout the history of YES, the Yankees have been a ratings juggernaut. The team has won consistently with a star-studded cast. Now they are winning without one.
Raissman also points out that other factors, such as the playoff games for the other New York teams (the Knicks, Nets, Rangers, and Islanders) and the debut of Matt Harvey with the Mets, may be impacting the ratings.
While lack of star power and playoff appearances by the other major sports teams in New York may have some influence, allow me to offer a counterpoint by applying the principle known as Occam's Razor.
Occam's Razor is the idea that sometimes the simplest answer is the right one, and I believe that there is a far simpler explanation for the low ratings this season: the Yankee announcers.
With certain noted exceptions (Ken Singleton and Jack Curry), the YES announcers (Michael Kay, Al Leiter, Paul O'Neill, and David Cone) are awful. There are points during each broadcast where it is simply painful to continue watching and listening. O'Neill offers nothing to a broadcast and the banter between Kay and O'Neill is forced and not amusing. David Cone's analysis consists of waiting for the replay and then just reciting what he sees ("…and he hits it to right field, and the right fielder fields it, and throws it to second base, and, as you can see, the runner slides in ahead of the tag.") Any time the cameras cut to Leiter holding a baseball in the booth to explain a pitch, I have to turn the channel. Leiter attempts to offer cogent analysis but he always comes across as a rambling, arrogant jerk. His "analysis" usually consists of incoherently stringing words and phrases together, while stuttering, and never really offering a firm opinion. (If Leiter uses the phrase "Bugs Bunny changeup" one more time, I am going to scream.) There is also no demonstrable chemistry between Kay and anyone else in the booth with him. And Kay really needs to spend more time preparing for games and working on his announcing skills and less time pretending to be knowledgeable about other sports for his radio show on ESPN.
What makes things more difficult for YES is the fact that one of the best broadcast teams in the country resides only a few channels away on SNY. Gary Cohen, Ron Darling, and Keith Hernandez with the Mets have great chemistry, provide insight, and are never afraid to call out the Met players for poor performances or misplays. Darling and Hernandez offer terrific analysis on every pitch and when showing a replay, the announcers actually breakdown what occurred. This is why my favorite time of the season is when the Yankees play the Mets because it affords me the opportunity to listen to these guys call a Yankee game.
It's inarguable that the quality of the YES broadcasts is at its lowest point ever. Poor broadcasting is a lot more noticeable in low-scoring games, like the ones the Yankees have mostly been playing this season, because it is incumbent upon the broadcasters to carry the show. To Mr. Raissman's point, not having a star-studded lineup is likely hurting the ratings as the powerful Yankee lineups in years past have always concealed the inadequacies in the YES broadcasting booth. In this way, the lack of star power this season has led to an unmasking of sorts and clearly revealed the ineptitude of the Yankee broadcasting team.


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Kaiserin Elisabeth, Vienna
10/10 Amazing Based on 1 Customer Reviews
Kaiserin Elisabeth Reviews
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Sunday, August 4, 2013
Best hotel in Vienna where I have stayed.
E.A., austin, texas
Perfect location, quiet street. First class staff. Comfortable, modern rooms, air conditioned. Full, extensive breakfasts. Excellent car service, to and from the hotel.
The best thing about my stay was ...
Excellent rooms


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The resounding message of Werner Herzog's Grizzly Man was that fraternising with wild bears will end in tears. "I believe the common character of the universe is not harmony," Herzog' s German-accented voiceover ran, over some lingering footage of a rotting animal carcass, "... but chaos, hostility, unt murder." Gordon Buchanan doesn't appear to have seen Herzog's documentary, in which bear-loving Timothy Treadwell was killed and mutilated by one of his furry chums. For The Bear Family and Me, Buchanan chose to spend a year in the wilderness of northern Minnesota with a group of black bears – smaller than grizzlies, but perfectly capable of giving an overfamiliar cameraperson a concussion with a clip round the ear. "When you look into a bear's eyes," the curly-haired Scot mused, "they've got a mad look about them." You could say the same of him. Buchanan's first clammy-palmed encounter with a bear, as he followed it into the woods alone with nothing but a beeping radio transmitter to discern its whereabouts, made for genuinely tense television.
Buchanan was aided in his quest by local bear biologist Dr Lynn Rogers, who introduced him to his favourite female, Lily, and her cute young cub, Hope. Rogers' methods are unconventional: he wanders calmly up to the formidable creatures and feeds them grapes to earn their trust. Eventually, he anticipates, they'll become so accustomed to his presence as to ignore him, thus allowing him to observe their authentic natural behaviour. (Won't they also, I wondered, become accustomed to the free grapes?)
During the course of filming, Buchanan was nipped gently in the thigh by Lily, but it was Rogers' scientific principles that really came back to bite him. The bear and her child became separated, and the scientist found the starving cub, which presented him with a dilemma: allow nature to take its course, or intervene to reunite his research subjects? Even Springwatch lets its ducklings die. But given that Rogers' assistant was blubbing, and that he'd sentimentally christened the cub "Hope" in the first place, what do you think he did?
As the teaser for tonight's second episode made clear, however, there's every chance that Hope may yet die anyway, a turn of events that would be truly Herzogian in its symbolism. As the wistful acoustic soundtrack started up, I could think only of the great Bavarian director's chilling words: "Chaos, hostility, unt murder"...
These, conveniently, were also the themes of ITV1's 9pm offering. Lynda La Plante's Prime Suspect rose above its generic title to become a televisual classic. Her latest creation, Above Suspicion: Deadly Intent, is unlikely to live long enough in the mind to transcend its two generic titles. La Plante might just as well have called it "Under Suspicion: Sudden Death", or "Crime Drama: Some Coppers Investigate Some Murders". It does, at least, feature Kelly Reilly and Ciaran Hinds as its chief investigating officers, both of whom have the chops to deliver their equally generic lines with almost enough conviction to be plausible.
The preposterous genre clichés piled up faster than the bodies: a bent ex-cop; a man who alters his identity with cosmetic surgery, then ungratefully knocks off the surgeon; an autistic savant with a head for numbers. The new drug I assumed La Plante and co had invented as their MacGuffin – fentanyl – actually exists (I looked it up) and is 100 times more powerful than morphine. Nevertheless, I'd stopped paying much attention to the plot by the end of the hour, once I realised I'd have to tune in to two more episodes to find out who the man with the new face might be, and whether the autistic chap can count matchsticks as quickly as Dustin Hoffman.
Rory McGrath has undergone a transformation (not, I must warn you, a cosmetic one) from professionally sarcastic panel show contestant to professionally earnest chronicler of provincial quirk. Remarkably, the first series of The Lakes, his show about a summer in the life of some charming Cumbrian eccentrics, seems to have passed me by. It must have done rather well, or else been generously funded by the British Tourist Authority, because the opening episode of the second series – back by popular demand! – was filled with expensive helicopter shots of the region's scenery.
I tend to distrust the notion, perpetuated here by McGrath, that country folk are somehow innately friendlier than city-dwellers. But sailing enthusiast Joe and his sailing enthusiast fiancée, Lindy, did seem jolly pleasant, as did Rob the micropig farmer, and marathon-running, Channel-swimming Thomas "Gladiator" Noblett, who was born with his feet the wrong way round.
Joe and Lindy's wedding plans were, naturally, sailing-themed, with the groom arriving by boat for the ceremony at Ullswater's Inn on the Lake. What went strangely unmentioned, however, was that the same hotel was once the setting for another television show called The Lakes: Jimmy McGovern's 1990s melodrama, filmed at Ullswater, boasted infidelity, gang rape and the drowning of three schoolgirls among its plotlines. The grittiest bit of drama in McGrath's version was weather-based: would the sun shine on Joe and Lindy's big day? Do bears shit in the woods?Reuse content


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Lifehouse - whatever it takes with lyrics MP3
Lifehouse whatever it takes + lyrics. This song touched my heart.. Hope you enjoy watching. Leave a comment and rating please! :) thank you!
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Track 2 ♫♪ from Leonas album teehee :P x http://www.smcmobilebeauty.co.uk.
Anita Baker Whatever It Takes MP3
Whatever It Takes by Anita Baker with Lyrics.
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i love this song made me cry, I share it with you now! EFY - especially for youth.
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Music video by Pillar performing Whatever It Takes. (C) 2010 Provident Label Group LLC, a unit of Sony Music Entertainment.
Whatever It Takes
PillarWhat would it take To make you see me The way I see you? What would it take To make you want me the way I've always wanted you? I don't know why You're in everything I see I can't deny Th[...]
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Research partnerships
Great science means sharing knowledge and resources to work faster and achieve more.
Academic collaborations are a rich source of creativity and scientific talent. Pooling resources and expertise can help the UK life sciences community to find and develop more new medicines and vaccines than by working in isolation. It's what we call our "R&D ecosystem".
Today, Pfizer contributes to more than 300 research collaborations and strategic alliances across the UK. Through these partnerships, we work with scientists, academics and clinicians to deliver world leading scientific research.
Through the Rare Disease Consortium (RDC), we are partnering with the Global Medical Excellence Cluster (GMEC) group of six leading UK universities, to identify and work together to develop new medicines for rare diseases, accelerating the discovery of new treatments for rare and devastating conditions.
But it's not just rare conditions where such collaborations can be beneficial. Lung cancer is the second most common cancer diagnosed in the UK after breast cancer and is the most common cancer in the world, with an estimated 1.61 million new cases diagnosed every year. Responding to this, we have embarked on a partnership with Cancer Research UK and AstraZeneca to create a pioneering clinical trial for patients with advanced lung cancer. The Stratified Medicine Programme (SMP) aims to make targeted treatments available for people with cancer in the UK.
In addition, scientists at Neusentis in Cambridge together with University College London and Moorfields Eye Hospital are working on a stem-cell based therapy for age related macular degeneration, a condition that leads to loss of vision.
Our partnerships in the UK extend far beyond the initial discovery of a new molecule. Our INSPIRE partnerships with the NHS in Newcastle, Scotland and Bath mean that these organisations are part of Pfizer's international network of preferred sites for clinical research, helping to bring innovative medicines to patients in the UK and around the world.
At last count, we had 75 ongoing clinical trials at 331 sites across the UK involving over 2,400 patients, enabling people in the UK to access the latest innovations in medical science.


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Those who worked with President Harold Hyde during his 26-year tenure as president of the College will remember his attention to detail. It will come as no surprise then, to know that Dr. Hyde left on file an obituary. What follows is published as written by Dr. Hyde in 1986, with only date and place of death added.
Harold Eldred Hyde
July 22, 1911 – April 1, 2001
Dr. Harold E. Hyde, President Emeritus of Plymouth State College of the University System of New Hampshire, died April 1 in Concord Hospital.
President Hyde was born July 22, 1911 in Hartwick, N.Y., the son of Howard C. and Bertha Eldred Hyde. He graduated from Hartwick High School in 1926. He earned a B.S. from Hartwick College in 1933, a M.S. from Albany State College for Teachers in 1939, and an Ed.D. from New York University in 1950. He was awarded honorary degrees from New England College, St. Anselm College, Hartwick College and Plymouth State College. He was also awarded the Charles Homes Pettee Medal for Distinguished Service to Mankind by the University of New Hampshire and the Robert Frost Contemporary American Award by Plymouth State College.
Hyde was a past president of the American Association of State Colleges and Universities, the New England Association of Schools and Colleges, the New England Teacher Preparation Association, the New Hampshire College and University Council, the New Hampshire Educational Broadcasting Council, and the Plymouth Rotary Club.
His educational career included service as teacher, researcher and administrator in various New York State communities, the State Department of Education in New Hampshire, and 26 years as president of Plymouth Teachers College and Plymouth State College. During his tenure at Plymouth, the college enrollment grew from about 250 to almost 3500 students. Buildings added to the campus during that time included a physical education center, a dramatics-music building, a library, a science building, an infirmary, an administration building, a college union, a dining commons, and a multi-purpose classroom building which bears his name. Also added were five dormitories and two student housing complexes.
President Hyde is survived by his wife, Mary Rita Oliver Hyde, and his daughter, Mary Ann Wolff.
Contributions in his memory may be made to Plymouth State College. A memorial event is being planned at the college for early May.


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Dream World 3: Revenge of the Nightmare is the sequel to Dream World 2: Return of the Nightmare, and is the third game in the Dream World Series. Once again, it takes place in the Dream World, and has many old features, but also has some new ones.
Release Dates
- USA: November 8th, 2013
- Japan: November 8th, 2013
- Europe: November 10th, 2013
- Australia: November 17th, 2013
Not too long after the events of Dream World 2: Return of the Nightmare, Dream Boy and Dream Kid are about to head back home, in their dimension, the real world, when the princess, Dream Girl, comes. She wishes them good luck. The two bow, and are about to jump into the portal, when Mr. Nightmare comes and kidnaps the princess! The portal back to their world is about to close, and they are told that if they don't return home now, before the portal closes, they will never get back home. As the portal shrinks, Dream Boy and Dream Kid can't decide what to do. Finally, when the portal is almost too small to enter, they make there decision. They run off to save the princess! The portal then dissapears.
After completing 4-6 (and defeating the boss there), Dream Boy & Dream Kid free Dream Girl. Mr. Nightmare appears that he doesn't care about the princess anymore, and that he doesn't need here anymore! He had the key that will unleash the King of Nightmares! He says that he will do that with his new and improved, Dream Killer 7000! He laughs, and runs off.
Playable Characters
|Dream Boy
|Can use the Dream Reviver to bring dreams back to life.
|Is a default character.
|Dream Kid
|Is the fastest playable character, and can do head-butts!
|Unlocked after Completing the First Level of Dream City.
|Dream Girl
|The princess of Dream World can use dreams to get an extra third-jump! She is also the only other person who can revive dreams.
|Unlocked after Completing Haunted Night
|Mr. Nightmare
|The main villian of the game, he uses the Dream Killer 9000 as his main weapon, and the Dream Killer 8000 to make Nightmarees!
|Worlds 1 through 6.
|Ultimate Nightmare
|The Final form off Mr. Nightmare!
|The Final Boss.
|The nightmare version of Flutterdreams, they are functioning every robot!
(Not a boss)
Every Level!
|King of Nightmares
|He is the real Final Boss of the Game!
Dark Hallow
- Dream City
- Balloon Palooza
- Summer Beach
- Haunted Night
- Winter Snowland
- Black Nightmare
- Nightmare Fortress
- Dark Hallow (Just a Boss Level)


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Weekend With Your Novel: Speakers
Instructors and critique workshop leaders
Christopher Chambers (MFA, University of Alabama) is an experienced editor, teacher, and writer. He's the author of Delta 88, and his work has been published widely in magazines and anthologies, including Best American Mystery Stories. He has received 5 Pushcart Prize nominations and a National Endowment for the Arts Fellowship. Work he edited has appeared in Best American Mystery Stories, Best American Nonrequired Reading, Best American Poetry, O. Henry Prize Stories, The Pushcart Prize anthology, Poetry Daily, Verse, Daily, and The Utne Reader. christopherchambers.net
Christine Desmet (MA, UW-Madison) is a novelist and short story writer, screenwriter, and writing teacher at UW-Madison where she specializes in one-on-one coaching of writers. Christine's latest projects include a best-selling, 3-book cozy mystery series for Penguin Random House called the Fudge Shop Mystery Series, set in Door County, Wisconsin. Christine's previous novel, a romantic suspense, Spirit Lake, was an award-winning, best-selling novel for publisher Hard Shell Word Factory/Mundania Press. Also a short fiction writer, her humorous romantic mystery series set in Wisconsin appeared in 2 volumes: Mischief in Moonstone, and Men of Moonstone. Christine is a past winner of the Slamdance Film Festival and optioned that screenplay to New Line Cinema. She's a member of Writers Guild of America, East; Wisconsin Screenwriters Forum; Romance Writers of America; Sisters in Crime; Mystery Writers of America; and Jewels of the Quill. Her stage play, "Climax!," about a struggling writer, was a top-10 finalist in a Wisconsin Wrights New Play Contest. In 2014, Christine received the UW-Madison Robert and Carroll Heideman Award for Excellence in Public Service and Outreach. christinedesmet.com
Matthew J. Hefti is the author of A Hard and Heavy Thing, Tyrus Books/F+W (January 2016). He was born in Canada and grew up in Wisconsin. After 9/11, he visited the Armed Forces recruiter. He then spent 12 years as an explosive ordnance disposal technician. He deployed twice to Iraq and twice to Afghanistan, once to Iraq as an EOD team member and the remaining three tours as an EOD team leader. While enlisted, he earned a BA in English and an MFA in Creative Writing. He is now working, studying, and living in Madison, Wisconsin, where he is pursuing his Juris Doctor at the University of Wisconsin Law School. He spends most of his time working for the Wisconsin Innocence Project, working to free the wrongfully convicted. His words have been seen in Pennsylvania English; Blue Moon Literary & Art Review; Chad Harbach's MFA v. NYC; and War, Literature and the Arts. Along with Adrian Bonenberger, David James, and Michael Carson, he writes regularly at Wrath-BearingTree.com. Visit his werbsite at matthewhefti.com.
Ian Graham Leask was raised in London and lives in Minneapolis. He is in his fourth decade of teaching all aspects of writing at places like The Loft, the University of Minnesota and COMPAS-writers-in-the-schools. He is the publisher of Calumet Editions, the founder of AuthorScope Services, a consulting group for writers, and hosts the long-running literary radio show in Minneapolis, KFAI's "Write On! Radio." He is the author of The Wounded and other stories about sons and fathers, and the novel House of Large Sizes. ianleask.wordpress.com
Jessica (Jess) Lourey is best known for her critically-acclaimed Murder-by-Month mysteries, which have earned multiple starred reviews from Library Journal and Booklist, the latter calling her writing "a splendid mix of humor and suspense." Jessica also writes sword and sorcery fantasy as Albert Lea and edge-of-your-seat YA adventure as J.H. Lourey, and is branching out into magical realism, literary fiction, and thrillers under her given name. She is a tenured professor of creative writing and sociology at a Minnesota college, a recipient of The Loft's 2014 Excellence in Teaching fellowship, and a sought-after workshop leader and keynote speaker who delivered the 2016 "Rewrite Your Life" TEDx Talk. When not teaching, reading, traveling, writing, or raising her two wonderful kids, you can find her dreaming of her next story. Salem's Cipher, the first book in her thrilling Witch Hunt Series, hits stores September 2016. jessicalourey.com
Agate Nesaule is author of A Woman in Amber: Healing the Trauma of War and Exile (Penguin, 1997) which won an American Book Award, and the author of In Love with Jerzy Kosinski, a novel (UW Press, 2009). She was born in Latvia and grew up in the turmoil of World War II. A professor emerita of English and women's studies at the University of Wisconsin–Whitewater, she lives, writes, and gardens in Madison.
Kristin Oakley's (BA, JD, UW-Madison) debut novel, Carpe Diem, Illinois, is the winner of the 2014 Chicago Writers Association Book of the Year Award for non-traditionally published fiction and a finalist in the Independent Author Network 2015 Book of the Year. The sequel, God on Mayhem Street, was recently released. Kristin is the president and co-founder of In Print, a professional writers' organization, a board member of the Chicago Writers Association, and the editor of The Write City Magazine. As a writing instructor at the UW-Madison Division of Continuing Studies, Kristin critiques manuscripts and offers an online course on cliffhangers. She has a B.A. in psychology and a J.D., both from the University of Wisconsin-Madison. kristinoakley.net
Angela Rydell (MFA, Warren Wilson College) has taught creative writing workshops throughout Madison. Her work has been published in Alaska Quarterly, Prairie Schooner, Poets & Writers, and other journals, and she won Portland Review's inaugural Flash Fiction Friday contest. She received honorable mention in the New Millennium Writings Awards Flash Fiction Contest, and was a finalist American Short(er) Fiction Prize and Gray Sparrow Flash Fiction Contest. She holds an MFA from Warren Wilson College and teaches for the UW-Madison Division of Continuing Studies. Her flash fiction can be read in Indiana Review, Gulf Stream, NANO Fiction and other journals, and she was interviewed on radio station WUWM for Lake Effect's Flash Fiction Friday.
Laurie Scheer (MA, DePaul Univ), Media Goddess, is a former vice president of programming for WE: Women's Entertainment. She has worked as an assistant, d-girl, and producer for ABC, Viacom, Showtime, and AMC-Cablevision. Laurie has been an instructor at numerous universities across the US including Northwestern, UCLA, American University, and Yale. As a professional speaker, she has appeared at annual conventions for NAB, NATPE, The Great American Pitch Fest, Screenwriters' World, Reel Screen, WIFV, FTX West, and the Willamette Writers Conference. She is currently an Associate Faculty Associate/Writing Mentor with UW-Madison's Continuing Studies Writing Department where she is critiquing writers' works, conducting numerous online and in-person courses, and the Director of the annual Writers' Institute. She is also the Managing Editor of the annual regional journal, The Midwest Prairie Review. Her new book The Writer's Advantage: A Toolkit for Mastering Your Genre (Michael Wiese Productions, 2014) explores storytelling in the transmedia universe. Most recently, Laurie received the Marquette University Alumni Association "James T. Tiedge Memorial Award" for her outstanding work as a graduate of the J. William and Mary Diederich College of Communication. lauriescheer.com
Tim Storm (MFA, Pacific Univ) has taught literature and writing for 14 years, working closely with both fabulist and realist writers. His work was chosen as Pacific University's sole fiction entry in the 2011 AWP Intro Journals Project, "a literary competition for the discovery and publication of the best new works" by MFA candidates, and he's the winner of the 2013 Reynolds Price Short Fiction Award for the title story from his MFA thesis: Creatures of the Deep. tdstorm.com
Aurelia Wills writes young adult and adult fiction. Someone I Wanted To Be is her first novel. She was raised in Colorado, attended UW-Madison, and graduated with a degree in philosophy and Russian studies. She teaches creative writing at the Loft Literary Center in Minneapolis. She reads first thing in the morning and last thing at night. A Tree Grows in Brooklyn by Betty Smith was the first novel she ever loved. Whenever possible, Aurelia attends live music shows, backpacks to state park cabins, goes on road trips, and travels by train. Once a year, she makes a papier-mâché puppet for the annual Mayday parade put on by the Heart of the Beast Puppet and Mask Theater in Minneapolis. She has three kids and lives in Minnesota with her husband. aureliawills.com


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PP_APO_REDUCTION_INDEP_REQ is a standard SAP function module that performs functionality. This is available within standard R/3 SAP systems depending on version and release level.
Below are the pattern details for this FM showing its interface including any import, export and tables parameters. There is also a list of Exceptions and for your convenience any standard documentation available. All this information and more can also be viewed if you enter the function module name PP_APO_REDUCTION_INDEP_REQ into the relevant SAP transaction such as SE37 or SE80.
CALL FUNCTION 'PP_APO_REDUCTION_INDEP_REQ' " TABLES xpbabx = " pbabx . " PP_APO_REDUCTION_INDEP_REQ


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Mother Being Forced to Have a C-Section
I don't post this so much for the petition but the story itself. I think change is needed in the medical community and a mothers' rights need to be protected. No mother should be forced to have a surgery she does not want. Period. It is her right to choose, that's why they offer you an informed consent form or whatever it is called when you go to a hospital. You do have the right to refuse to sign it (but if you don't sign it you won't be treated) but you can cross out things you do not agree with on it and most do not realize this.
What do you think of this story?
I didn't know you could cross things out. I agree... It should be the mother's choice.
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***Baby Team Leader Moms.com*** I have been married for over 20 years. My husband and I have eight children ages 18 down to 4 years old. We use to live in Chicago but now live in Canada. I own www.FaithandFamilyReviews.com.


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Warden Willie Bolton of the Athens-Clarke County Department of Corrections graduated Wednesday from the Rural Executive Management Institute (REMI), an executive management education program that was held in Columbia, S.C.
The classes were presented by a faculty of experts brought together by the National Center for Rural Law Enforcement (NCRLE), an organization based in Little Rock, Ark.
Bolton has been warden and director of the Athens-Clarke County Department of Corrections since 1994. He has a bachelor's degree in criminal justice and a master's in criminal justice administration from Atlanta University.
REMI is a four-day education and training course designed exclusively for rural sheriffs and chiefs of police.
Published in the Athens Banner-Herald on Saturday, April 3, 2004.
© 2017. All Rights Reserved. | Contact Us


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After getting torched in two consecutive national championship games, Ohio State's football team is used to criticism. But now the 8-2 Buckeyes are taking a hit from one of the school's legendary coaches.
On a radio show in Ohio this week, Earle Bruce decried the performances of the guys who are supposed to be blocking for Ohio State's ball carriers.
"The people who are the underachievers are the people on the offensive line," said Bruce, whose record at Ohio State was 81-26-1 from 1979-87.
"The people on the offensive line have to play physically tough and they have to be mentally into every game," Bruce said. "We've had some injuries and have lost some guys there, but that's one area we could be better at."
Bruce, 77, is the Ohio State analyst for WTVN-AM radio in Columbus.
Reid Cherner has been with USA TODAY since 1982 and written Game On! since March 2008.
He has covered everything from high schools to horse racing to the college and the pros. The only thing he likes more than his own voice is the sound of readers telling him when he's right and wrong.
Michael Hiestand has covered sports media and marketing for USA TODAY, tackling the sports biz ranging from what's behind mega-events such as the Olympics and Super Bowl to the sometimes-hidden numbers behind the sports world's bottom line.


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New Delhi, Apr 26: Mumbai Indians will be certainly boosted after their stunning victory over Kings XI Punjab on Wednesday, but Delhi Daredevils definitely start favourites when they take on Tendulkar and Co at the Ferozshah Kotla in New Delhi on Friday, April 27.
Losing two games in a row, Mumbai Indians took revenge against Kings XI Punjab with the help of Ambati Rayudu and Robin Petersen's innings towards the end on Wednesday. Mumbai had lost the first leg against Punjab with just three balls to spare, while in yet another thrilling end, Mumbai won with only a single ball remaining.
In a return leg match, seventh placed Mumbai Indians will take on league leaders Delhi Daredevils. After the return of the batting legend Sachin Tendulkar, Mumbai Indians top-order seems steady, crossing the 160-run mark in two matches.
While their top-order batting looks in good shape for now, Mumbai Indians lack game changers in their side. West Indies all-rounder Kieron Pollard has been inconsistent with the bat except his match-winning knock against Rajasthan Royals, but is the highest wicket taker in the side with 11 wickets.
In six innings put together, Harbhajan Singh, the Mumbai captain, has bowled 22 overs for 1/164. He has not produced economical spells which would have compensated for lack of wickets.
With Lasith Malinga ruled out, Mumbai's bowling looks weak despite the likes of RP Singh and Munaf Patel in the side. Their bowlers will be tested against world-class batsmen Virender Sehwag, Mahela Jayawardene, Kevin Pietersen and Ross Taylor.
Meanwhile, the Daredevils have never batted first in seven matches, majority of their wins are due to good starts at the top order. Sehwag and Pietersen are in good form while Mahela Jayawardene and Ross Taylor have yet to score big.
The bowling attack has been consistent so far, with Morne Morkel leading with 16 wickets while other bowlers like Irfan Pathan and Umesh Yadav have been little too expensive. Wicket-less in his last two encounters, Daredevils sensation Shahbaz Nadeem has had an excellent season so far.
Both teams will look to extend their winning streak. Mumbai Indians will eye revenge after a humiliating defeat in the first leg at the Wankhede on April 16, while Delhi Daredevils will look to stay at the top of the table.
Delhi Daredevils: Virender Sehwag (captain), Mahela Jaywaredene (vice-captain), Naman Ojha (wicket-keeper), Kevin Pietersen, Ross Taylor, Y Venugopal Rao, Yogesh Nagar, Irfan Pathan, Roelof van der Merwe, Morne Morkel, Umesh Yadav, Shahbaz Nadeem, Andre Russell, Aaron Finch, Doug Bracewell, Ajit Agarkar, Varun Aaron, Aavishkar Salvi, Robin Bist, Sunny Gupta, Pawan Negi, Punit Bisht (wicket-keeper).
Mumbai Indians: Harbhajan Singh (captain), Sachin Tendulkar, Abu Nechim, Amitoze Singh, Aiden Blizzard, James Franklin, Kieron Pollard, Y Chahal, Herschelle Gibbs, Davy Jacobs, Richard Levi, Dinesh Kartik (Wicketkeeper), Dhawal Kulkarni, K Yadav, Lasith Malinga, Sushant Marathe, Pragyan Ojha, Munaf Patel, Robin Peterson, Sujit Nayak, Rohit Sharma, Suryakumar Yadav, Jaydev Shah, Rudra Pratap Singh, T Suman, Pawan Suyal, Aditya Tare, Apporva Wankhede.


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
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supply oil filter
High flow double filter for industry---Introduction
1.Material:stainless steel, carbon filter;
2.Application: This filter is widely used in metallurgical machinery , mining machinery , heavy-duty machinery etc hydraulic system;
3.Structure:Switching valves(1 piece);
pressure gauges (2pcs);
Differential pressure transducer(1 piece);
Housing and filter element(2pcs);
Balanced valve (1 piece);
gasket and O-ring(2sizes ,2pcs);
asbestos pad(2pcs);
flat gasket,bolts and nuts(16sets);
4.Working principle: There is only one filter to operation in normally work . You can not stop the system then open the pressure balance valve and roll reversing vales .switch to another filter to work , when the filter pressure loss exceed(more than 0.35 MPa ) and then clean or replace the filter element.
High flow double filter for industry---Operational process
1. Filter installation is completed , open the inlet and outlet valve of the filter , the system start to working;
2. When the differential pressure transducer is alarm (differential pressure is achieved 0.35MPa), pls change the conversion valve and let another filter to work;
3. Open the vent valve(on the upper cap) and blowdown valve (on the bottom cap), let the dust fluid drain off the filter completely;
4. Open the upper cap of filter , take our the filter element;
5. Clean or change the filter element , then install the filter element and upper cap;
6. Closed the vent valve and blowdown valve and open the inlet and outlet valve of the filter;
7. The best advantage of the duplex filter is when the element need to change or clean , don't need stop system working.
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text:
Making Seed-Stage Investing Easier
(The following dispatch was originally posted on sister blog Digits, which covers the technology landscape.)
A rising class of professional "angel" investors – who typically put sums of less than $1 million to work in a start-up company – is changing the venture-capital landscape. Now these angels and their smaller investments, dubbed "seed" stage investments, have their own set of legal documents to go with them.
Ted Wang, an attorney at Silicon Valley law firm Fenwick & West, is on Monday launching a set of seed-stage documents – dubbed Series Seed docs – that he says will cut down the time and cost of making such investments. The problem: Legal documents associated with investing in a start-up – whether an investor is pumping in less than $1 million or more than $10 million – remains unchanged from years ago. A typical set of such documents usually weighs in at more than 100 pages, says Wang, which considerably drags out the length of time and cost in completing one of these investments.


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Admire the most beautiful places of Predappio and add them to your basket. YAMGU will create your trip considering distances, opening hours and weather.
Dates back to the thirties of the past century the construction of this theater place near the main street of Predappio. The building was built according to the rules laid down at the time for the public to recreation. Originally was called Opera Nazionale Dopolavoro, subsequently assumed the name Cinema Italy. inside, in addition to room for the theatrical and film were placed for both offices environments and for other recreational activities and entertainment. The structure was completed by an external, Park place left of the building, which took place summer activities and outdoor games.


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What lengths would you go to to try and find a missing child? That's the question being asked by the new thriller coming our way called Beyond. Let's hope they go really far. Unreasonably far. The kind of far that could only lead to the darkest side of life and death.
According to The Hollywood Reporter Teri Polo (pictured right; Little Fockers), and Dermot Mulroney are joining Jon Voight to star in Beyond, a thriller from Crystal Sky's subsidiary Crystal Edge. Julian Morris also stars.
Joseph Rusnak (The 13th Floor) is sitting behind the camera for the $10 million production, which is currently shooting in Alaska.
The story centers on a veteran detective and a questionable television psychic who will stop at nothing to find a missing child. Polo is playing Voight's daughter and the mother of the child. Look for more as it develops.
Got news? Click here to submit it!
Find the missing in the comments section below!


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When it is time for Alyssa Thomas goes off to college, she is left heartbroken after a messy breakup with her unfaithful ex. Instead of letting her despair swallow her, she throws the biggest party the city has ever seen. One Direction happens to be playing that night at a venue nearby, and decide to make an appearance after intercepting word of the party. Niall is automatically attracted to Alyssa, who is in a vulnerable position from her recent breakup. They take things way to fast, making a mistake that proves to be One Direction's best kept secret, but not for long, because the night changes all too fast.
niashiroran Jun 04
No gurl you aint old. Im a senior in high school and Ill alsways have posters of 1D 😂
UnspeakableLies Jul 30, 2016
Yeah I bet a slut tries to deepthroat but it only ended getting it passed her teeth.
Farihaoishy4 Nov 30, 2016
Wooww.. Cool .. So Niall is mine ( just kidding) !!😆😆😂😂😍😍😍😍
dancewithgrace Sep 25, 2016
More like. GODSENT. THEY ARE PERFECT. THEY ARENT HUMAN CUS HUMANS CANT BE AS PERFECT AS THEM. 😻😻😻😻😻😻😻😻😻😻


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Koll Duo Glide
Product Code:
$ 2,650.00
A great looking guitar handcrafted by Saul Koll and his team in his workshop in Portland, Oregon. The guitar features a beautiful metallic blue finish and a pair of Lollar P-90 pickups. With very few signs of use, this guitar is in excellent condition and comes with the original hard shell case.
- BODY: Chambered mahogany with flat maple top
- NECK: Mahogany, set neck, medium C shape
- HEADSTOCK: Macassar ebony veneer w/Koll pearloid inlay
- FINISH: Nitrocellulose lacquer
- NUT WIDTH: 1.687" hand-cut unbleached bone
- BINDING: single layer on top, fretboard, and headstock
- FRETBOARD: Rosewood, 10" to 14" compound radius
- FRETS: Jescar .090 x .055 medium jumbo
- TUNERS: Schaller G Series Keystones
- CASE: Original Hard Case


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WHEN IS THE BEST TIME TO PERFORM SCANS ON OPEN PORTS OF A NETWORK? Monthly. For most companies a monthly scan is adequate to ensure that the incoming connections are only for known services and that the ports haven't been penetrated by intruders or malware, says Chester Wisniewski, senior security advisor with security vendor Sophos. Tip: In addition, ports should be carefully checked on a system after it is provisioned for the first time, and whenever new software is deployed, he says. Administrators should remember to check for UDP (User Datagram Protocol) ports as well, which the recent Conficker worm exploited.
Administrators should document what they find after each scan, says Wisniewski. "Careful documentation of what has been opened and why can help close holes for services that have been discontinued, and prevent accidental ports being open to new servers taking on the address of the old ones," he says.
This is part of ITworld's "Best Time" series. See the full list of Best Times to do all sorts of technology-related things. Think you know the "Best Time" to do something? Send to firstname.lastname@example.com.


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Iron Heroes is a set of variant rules for the d20 System, written primarily by Mike Mearls and originally published by Monte Cook's Malhavoc Press. It is a complete game, and does not require the Dungeons and Dragons rulebooks.
History Edit
The game was originally announced as "Iron Lore", but this was contested by Iron Lore Entertainment, developers of the computer roleplaying game Titan Quest. The title was changed before release.
Ownership was transferred by Cooke on March 1, 2007 to Adam Windsor, a freelance writer who worked extensively on the official errata for Iron Heroes almost since the product's release. Further titles in the line are being published by [Fiery Dragon Productions]. In addition, other companies have published third-party adventures and other OGL material for Iron Heroes.
Description Edit
Iron Heroes redesigns or expands many of core features of the d20 system, especially the combat, feat, skill and magic rules, to suit generally low-magic campaigns focussed on action and combat. It is designed to be independent of any particular campaign setting, instead geared towards serving a gritty, darker genre of fantasy, and Dungeon Masters are encouraged to develop their own settings for use with the game. These two main features are in sharp contrast to Cooke's own Arcana Unearthed and Arcana Evolved, which comprised a developed high-magic campaign setting with rules which expanded magic use and power in that setting.
Characters Edit
Iron Heroes characters do not acquire magical equipment or supernatural abilities as they gain levels, as is normal for most characters in Dungeons and Dragons style fantasy campaigns. Instead they train in various combat styles and ability trees, granting them numerous skills and combat options. Most classes gain access to a pool of tokens that may be spent to perform extraordinary feats. These tokens represent an inner resource (e.g. bloodlust, focus or superior knowledge) or advantageous circumstance (usually created by the character; e.g. spending time aiming at a foe before firing, or deceiving an opponent with feints).
Magic Edit
Magic is generally perceived as evil, corrupting and dangerous; only one heroic class is able to make use of it, though various forms of magic are available to some of the villain classes introduced in Mastering Iron Heroes.
See also Edit
External links Edit
- Iron Heroes - Fiery Dragon's official web site
- Iron Heroes FAQ and Errata - Wiki maintained by Adam Windsor
- Monte Cook Presents: Iron Heroes - the old official web site


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Savannah Petroleum says that its Agadem Rift Basin Full Tensor Gradiometry (FTG) survey has now been completed. The 36,949km of acquired data will now be processed and interpreted, and the results will be integrated into Savannah's Agadem basin subsurface model alongside the existing large 2D and 3D data sets Savannah is currently interpreting.
Andrew Knott, CEO of Savannah Petroleum, said:
'The operational completion of the FTG survey marks another important step for Savannah. We are pleased that it was completed ahead of time and on budget and believe it will prove instrumental in advancing our understanding of the basin.
Over the coming months we now expect Savannah to enter a period of increased corporate newsflow, with our updated exploration leads and prospect inventory expected in mid H1 2015.
Savannah Petroleum
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text:
Hey Everyone,
I have talked in here about being "pathological" in your approach to serving others
and putting your best foot forward when doing so. I hope it becomes a passion
for you as the rewards are great. The feeling you get when you go above and beyond
in helping-serving others, whether it's a volunteer position or helping in the community
or being paid to serve.
My pathological notion is about giving incredibly crazy unwavering full on service to others.
Always going above and beyond is what it's all about in anything you do but especially
when working with others.
Hats off to anyone who pursues the pathological approach when serving others.


text:
Gossip Nostalgia Articles
A look back at celebrity news and gossip of yesteryear.
Gossip Nostalgia: Ben Affleck & Jennifer Garner in Vancouver
I miss you, Vancouver. It's Thanksgiving and I miss you. STAR Magazine via Celebitchy just gave me a reason to write about it. According to STAR, Ben Affleck will be shooting Superman & Batman in Vancouver. And since he supposedly fingered a girl in Vancouver while he was engaged to JLO, they're saying Jennifer Garner's going to lock him down when he's there because she hates how he behaves in Vancity…what? This is why it's amateur hour over at STAR. Full Story
The women in Joaquin's life
Neilson Barnard/ Dimitrios Kambouris/ Getty
"The Lunchbox Fund is a non-profit organisation dedicated to providing a daily meal for orphaned and vulnerable school children in township and rural areas of South Africa, a country where 65% of all children live in poverty." The Executive Board in the US includes Joaquin Phoenix, Rain Phoenix, Summer Phoenix, and Topaz Page-Green. Full Story
Posh in Paris and it's Fashion Week
FameFlynet, KCS Presse/ Splash
I don't know if she's there for Fashion Week, but it can't be a coincidence either, right? Posh is a proper designer now. Paris is where the top designs live. Today she was at a meeting at the British Embassy. Don't you love the drama of how her long jacket is whipping around in the wind? What am I going to say next? You know what I'm going to say next. Full Story
2000 all over again
OMGGGGGGGGGGGGGGGGGGGG! 'N SYNC reunion! Justin Timberlake is receiving the Michael Jackson Video Vanguard Award at the MTV VMAs this year. According to Page Six, as part of the tribute, 'N SYNC will perform together – for the first time in, well, in over a decade. Full Story
Madonna: birthday paintball/Sean Penn: birthday in Ibiza
Both Madonna and Sean Penn celebrate birthdays this week, a day apart. She'll turn 55 on August 16 and he'll be 53 on August 17. It's been almost 25 years since they divorced. 25 YEARS!!? Yesterday Madonna was celebrating another birthday – her son, Rocco is now 13. Full Story
Emma Roberts's tears
Pacific Coast News
""Julia needs a lot of hugging and holding." – Garry Marshall, director of Pretty Woman, on Julia Roberts when she was 23. 23 is when Julia Roberts called off the wedding, just days before she was supposed to marry Kiefer Sutherland. You forget, sometimes, being that she's become so haughty and sanctimonious, that Julia Roberts was That Girl. Full Story
Beverly Hills 90210 Reunion in Vegas
Denise Truscello/ Getty
Remember the modified version of the 90210 theme song they would play when the show came back from the commercial break for the last block of an episode? It wasn't exciting like the opening but really slowed down? Sort of sad and yet comforting, to indicate that Brandon or Brenda has learned a lesson the hard way? That's what I hear when I look at these pictures of this week's 90210 reunion. Full Story
A year ago today...
FameFlynet, Pacific Coast News
That's 52 weeks ago... June 29, 2012... A Friday... I was in studio at CTV Vancouver shooting my hits for etalk. My window is usually from 9:30am - 10am PST. I wrapped up and it happened. An announcement: Katie Holmes had left Tom Cruise. This would kick off a solid three months of amazing scandal. Full Story
Gaby Hoffmann's Revenge on Mel Gibson
Alberto E. Rodriguez/ Getty
Out of nowhere today, Gaby Hoffmann is back! As if it wasn't delightful enough just to see an old familiar/beloved face from your childhood (or mine anyway), she's returned to reveal wonderfully horrible details about Mel Gibson: "He screamed at me. Oh, God, he really screamed at me," is how she described working with Mel, otherwise known as The Perpetual Motion Machine of Hate and Creepiness. Full Story
Blonde Ambition 2013
Dimitrios Kambouris/ Getty
Madonna was in New York last night for the screening of her MDNA tour film. As you can see, she's revived her interpretation of Marlene Dietrich, the "double drag". (Click here for a good scholarly read on "double drag". Full Story
Nicole, Keith, and Lenny!
Rick Diamond/ Jason Merritt/ Getty
Remember when Nicole Kidman dated Lenny Kravitz? For that matter, remember when Nicole Kidman dated Q-Tip?!? Right?! You totally forgot! Nicole Kidman and Q-Tip! Yes. Before Nicole found Keith Urban, she was with Q-Tip and she was with Lenny. And last night, as she accompanied Keith to the CMT Awards, they all ran into each other backstage and posed for a photo. Full Story


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Forge Motorsport intake kit for Ford Focus Mk2 RS
5 to 7 days
This Induction kit has been developed for the Ford Focus RS MK2. Whilst the original intake system proved to be very efficient, Forge were able to make an improvement by combining a low resistance filter capable of flowing a high volume, sited to maximise cold air, along with a tuned inlet tract. On our test vehicle we gained 9 hp over the original air box with no other modifications. With software tuning and an uprated intercooler, greater gains will be seen
- Select your hoses color -
Specificly designed for Ford Focus Mk2 RS
Easy direct bolt on
9hp dyno proven gain on stock engine
Black Aluminium "cold air" style pipe
Non oiled cotton gauze high flow cone filter
Instructions and hardware included
|Focus 2