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Lato Milk was bestowed with another honor at Tanzania Leadership Award 2016the Tanzania Leadership Award 2016 by winning the Best new company of the year award 2016. The award comes after Lato Milk's one year of successful operations in Tanzania.
Category: News & Events
MiDCOM Group sponsors Diwali Scramble 2016 at Emirates Golf Club
MiDCOM group held its third successive annual Diwali Scramble Golf Tournament on the 29th of October 2016 at the picturesque Majlis course at Emirates Golf club. Every year, this event draws avid golfers from all over the UAE and this year was no different as this year witnessed a fabulous turnout of 128 players. Gokul Mani, Pavan Nihalani, Ian McDonald and June Mcdonald combined well on the Majlis course to make an array of birdies and win the Midcom Diwali Scramble with a 58.2 tally. The competition was strong with only 0.4 points separating the top three teams. Stathis Stathis, Haris Michaelides, Naima Maya and Tania Sangani signed for a 58.5 total to take runners-up place. Ishu Rupani, Harish Rupani, Ed Hesson and Eddie Hesson also produced an excellent display with a 58.6.
The event was followed by games were and a cultural extravaganza where there were special Bhangra and Contemporary dance performances showcased by students of a well-known dance academy in Dubai. The evening concluded with a grand gala dinner and party that carried on till the wee hours of the night.
A special thank you to all the participants and guests for their support and enthusiasm. Here's wishing everyone a wonderful year ahead!
FERO hosts Launch Event at iHub, Nairobi
Looking to expand its footprint in the vast and ever so desirable Kenyan Smartphone Market, FERO recently unveiled its latest range of mobile phones with a press conference at the iHub Technical Innovation Center in Nairobi. Local media, Tech Bloggers and business representatives were presented with a firsthand experience of all FERO smartphone models currently available in Kenya. FERO smartphones will now be available in all the major retail stores across the country.
FERO continues to expand its reach across the East African market and ensures to pay close attention to different consumer needs within the nation. Kenyan consumers can expect total support for their devices in the future, as well as new unannounced releases soon.
The Royale series has to be the most beautiful range of gadgets I've ever seen #Fero #ExploringNewPossibilities @KevinKeya @ferodevices— | Susan Mukami | (@S_MukamiKE) September 14, 2016
#FERO @ferodevices the phone made in Africa for Africa #RoyaleSeries — victor mbaja (@mbaja_victor) September 14, 2016
New brand and with elegance, strength and durability #ferodevices #FERO #ExploringNewPossibilities — Nelson Kwaje (@nelsonjkwaje) September 14, 2016
The coolest brand that fit your pocket #FERO https://t.co/UtXAUT98vO — Calvin Jodisi (@calvinjodisi) September 14, 2016
Country wide service centre coming soon . Already in nairobi. Get your fero phone @ferodevices @KevinKeya #FERO— kayalice (@kaykanda) September 14, 2016
MStore brand expansion in Africa
MiDCOM focuses on retail growth with MStore's retial expansion
MStore retail operations to grow from 300 outlets to over 2,000 outlets by 2020. The expansion will make it the largest mobile and electronics retailer in Africa.
MStore currently has a presence across Kenya, Tanzania, Uganda, Rwanda, Nigeria, Ghana and Togo. The retail expansion will see the store increase its presence in these markets and enter new markets, including Chad, Ivory Coast and Senegal.
Mr. Akash Kumar, Midcom Group's managing director, said: "The expansion of MStore is the latest realization of that growth strategy, which any other international organization moving into these markets would struggle to replicate.
"The expansion of MStore will support another of our businesses, FERO, the line of mobile phones we recently launched, by providing full sales and technical support to Fero customers across our markets." Midcom Group's new Fero range of mobile phones are designed in the UAE specifically for Africa and Middle East markets, offering 16 models.
The retail store also provides technical support for customers facing issues with their devices, with a 48 hour turnaround time guarantee to resolve customer issues.
Read More:
Midcom to launch 100 new Kenya stores in Africa growth: Business Daily Africa
Phones distributor Midcom to spend Sh5bn on new stores: The Star
Midcom in KSh 5 billion retail expansion plan: Business Today
Midcom Group is to invest USD 50 million to create the largest mobile and electronics retail operations: African Telecoms News
Mobile phone vendor Midcom to invest $50m to fuel its pan-African expansion: Techmoran
Lato Milk sponsors Bright Stars Football Club
Lato Milk is proud to sponsor Kawempe based premier league club Bright Stars FC ahead of their 2016/17 season which kicks off 19th August
The new jersey was officially revealed to the media on Wednesday morning at the Midcom offices, Acacia Avenue in Kampala.
Mr. Shayam Kotech, Director, Lato Milk said "I am very delighted to partner with Bright Stars football club. They are a very organized and have a big following to give our company mileage as we also start the journey of venturing into football."The event was also attended by the Fufa president Eng. Moses Magogo who hailed the deal noting it's one of the eight pillars of football development towards pro agenda.
"I don't' think there is any person happier than me. This is in line with the agenda of professionalizing football. I am very excited that clubs are getting partners and sponsors in line with the eight pillars of football development," Magogo said.
Read More:
Bright Stars football club acquires shirt sponsors: Bright Stars FC
LATO in sponsorship deal with bright stars: Chimp Reports
Bright Stars FC to eat like kings from Lato Milk: Showbiz Uganda
Bright Stars FC announce LATO Milk as their new official sponsor: Soka25east
Azam Uganda Premier League side bright stars land UGX 130m boast from Lato Milk: The Investigator News
Bright Stars unveil shirt sponsor ahead new season: Big Eye
Bright Stars secures 100m USh LATO Milk sponsorship: NewVision
FERO Mobile Phones launched in Middle East and Africa
We recently announced the launch of a new range of mobile phones designed in the UAE specifically for the African and Middle East markets. The new mobile brand, FERO offers 16 models, from entry-level feature phones through to sophisticated premium smartphones targeting the top end of the market.
Mr. Akash Kumar, Managing Director, MiDCOM Group said, "We have been a distributor of all leading mobile phone brands in Africa for the last 13 years, so we already have an extensive network and partnerships in place for channel and distribution, catering to the major African markets," he said. "The years of experience and in-depth market knowledge made it an obvious choice for MiDCOM to launch its own brand. Consumers are very well informed, and good quality products at competitive pricing is paramount. This, coupled with the logistics of distribution in Africa, is the barrier to others and the real strength of MiDCOM"
The full product range will now be on sale in Kenya, Nigeria, Tanzania, Ivory Coast, Ghana, Uganda, Rwanda, Senegal and Togo.
Read More:
- Midcom Group launches mobile phone range for Africa and Middle East: GulfNews
- UAE-based Midcom Group launches mobile phone range for Africa and MEA: Emirates News Agency
- Midcom launches mobile phone range for Africa and ME: Business Zoom
- UAE-designed mobile phone launched for MEA: Gulf Today
- UAE mobile company to tap African market with $8 phones: The National
- Midcom Group launches mobile phone range for Africa and Middle East: World News
- UAE conglomerate targets MEA mobile device market: Mobile World Live
- Midcom Group launches mobile phones for the African market: Techloy
- UAE-based Midcom Group Launches Mobile Phone Range: Mediavataarme
- New producer to capitalize on existing African network with 16 handsets: Your Communication News
- Midcom Group launches mobile phone range for Africa and Middle East: Headline News
- UAE mobile company to tap African market with $8 phones: Total UAE
- Midcom Group makes play for middle ground in MEA device market: Fierce Wireless
President Museveni commissions Pearl Dairy Farms Ltd
The President of Uganda Yoweri Kaguta Museveni commended Pearl Dairy Farms for its intensive financial investment in the country and generating employment in the region.
At the event he said "Uganda currently generates 2.2bn litres of milk but only consume 800m liters. We currently sell USD 50m per year worth of milk, but with endeavors like these we shall certainly be making six times that (USD 300m) in a few years. Surprisingly, we have been able to generate this much milk and yet feed our cattle rather sub-standard grass. If only our people could pay more attention to the type of grass they feed their cattle, we would be doing much better."
Midcom Group started Pearl Dairy in 2013 and has for the past three years bought over 200 million liters of milk from farmers by offering competitive prices amidst seasonal fluctuations and global dairy prices.
Mr. Bhasker Kotecha, the Founder and Chairman of Midcom Group expressed his gratitude to the different stakeholders who have played "pivotal roles" in the success of the company.
"Pearl Dairy Farms is thankful to the Government of Uganda under the leadership of His Excellency Yoweri Kaguta Museveni for the conducive and attractive policies; both investment and economic that have enabled Pearl Dairy exist and flourish in Uganda" he said.
"Furthermore, the ministry of Agriculture, Animal Industry and Fisheries and the Dairy Development Authority have been pivotal with continued guidance. Last but not least, the farmers that have consistently supplied us with high quality milk consistently without waiver- we are eternally grateful," Mr. Kotecha, added.
Devendra Seth, Managing Director, Pearl Dairy said that they will continue to provide training to farmers and cooperative societies and on strategies to stimulate milk consumption.
As part of their quality control measures, Pearl Dairy Limited has also distributed over 2000 milk cans to farmers at no profit in order to ensure clean milk transportation from the farm to the factory. Pearl Dairy Farms Ltd also shares best practices with farmers in milking, milk handling and hygiene.
Read More:
- Museveni commissions Pearl Dairy Farms: The Insider
- Uganda: President Museveni Commissions Pearl Dairy Lato Milk: All Africa
- President Museveni commissions Pearl Dairy LATO milk: BusiWeek
- President Musevni officialy commissioned Pearl Dairy Farms Ltd: Xclusive
Forbes Middle East awards Mr. Anand Kapoor as Top Indian Business Leaders in the Arab World 2016
Mr. Anand Kapoor, Founder and Vice Chairman of MiDCOM Group has been felicitated by Forbes Middle-east as one of the Top Indian Business Leaders in the Arab World, 2016. It is a matter of great pride for the group as he has been conferred this honor for the fourth year running.
He now ranks at 41st position in the Forbes Top Indian Business Leaders in the Arab World. The felicitation ceremony was held at the Waldorf Astoria Hotel in Palm Jumeriah, Dubai.
Mr. Anand Kapoor shares his insight at Africa CEO Forum in Cote'd Ivoire
Founder and Vice-Chairman MiDCOM Group, Mr. Anand Kapoor was invited to share his insights on the challenges of doing business in Africa and how the economy has shaped in the recent years at the 2016 edition of the Africa CEO Forum, held in Abidjan – Cote d'Ivoire. A total of 1300+ companies participated in the event bringing together the most influential figureheads in global finance and the CEO's of the continent's biggest companies. He stressed on the value proposition that brands offers originating from Africa and how the brands have changed their marketing objective with respect to the aspiration values of customers in East and West Africa.
The two day event saw participants exchange their views and opinions on the issues affecting the economic development of African companies.
MStore partners with TIGO to launch 26 retail stores in Ghana
The African telecom giant Tigo partnered with Mstore, the multi-brand retail enterprise of MiDCOM Group to launch 26 retail stores in Ghana. Continuing its successful association with Tigo in Tanzania, MStore strengthened its partnership to provide customers with the best mobile phone shopping experience. The partnership and the Samsung S7 launch event was held at the Tigo Head office in Accra, Ghana.
Mr Anand Kapoor (Founder & Vice-Chairman, MiDCOM Group) and Ms. Roshi Motman (CEO, Tigo) signed the strategic partnership agreement which will enable both the companies to establish a cooperation in providing excellent customer mobile phone shopping experience. Mr. Anand Kapoor addressed the media "We are very happy to have signed this agreement with Tigo. This partnership will strengthen both ours and Tigo's offering and add value to our customers. We very much look forward to working together with Tigo in Ghana." He further added that "the Mstore-Tigo partnership will benefit our current and future customers greatly."


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I liked the atmosphere of this hotel. Every one was nice. It's in a good location, easy on easy off the freeway. The city seems a little sleepy though. Our room was clean and well furnished. We will be coming back if we're ever in Carson City again.
- Official Description (provided by the hotel):
- Welcome to the Holiday Inn Express Hotel & Suites Carson City, Nevada. We are conveniently located off scenic North Carson Street (Business 395) on the north end of Carson City across from the Green Golf Course near the Nevada Capitol Building, casino gaming and restaurants. This beautiful hotel is only 30 miles from Reno Tahoe International Airport and all Reno attractions, 30 miles from Lake Tahoe and 17 miles from Virginia City. Special in-room amenities are: free wireless high-speed Internet, 27' TVs with HBO and Pay-Per-View, microwave & refrigerator, 2 line phones with free local calls, work space, hair dryer and free parking. Luxurious granite appointments including bathroom surrounds, counter surfaces along with granite vanity tops were installed for a touch of class. We have 20 suites and a Honeymoon Suite, which come with a wet bar, separate living area, sofa bed, activity table and 2 chairs. Take a dip in our heated year around indoor swimming pool and spa . Other amenities include a fitness room, guest laundry and meeting facilities. Wired and wireless Internet is available in the lobby and in all rooms, pool and breakfast area.Visit Carson City, NV and Stay Smart at the Holiday Inn Express Hotel & Suites.There is a computer with Internet access in the lobby for guest use. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Priceline, Orbitz, IHG, Hotels.com, Travelocity, Hotwire, TripOnline SA, Cancelon, getaroom.com and HotelQuickly so you can book your Holiday Inn Express Hotel & Suites Carson City reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Holiday Inn Express Hotel And Suites Carson City
- Holiday Inn Carson City
- Carson City Holiday Inn
- Holiday Inn Express Carson City

subset: commoncrawl


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Jerry Goldsmith
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|Action & Adventure Movies Classical Comedy Movies Drama Movies Holiday & Seasonal Movies Horror Movies Kids & Family Movies Mystery & Thriller Movies Pop / Rock Sci-Fi / Fantasy Movies Soundtrack Television War Shows & Movies Western Movies
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Jerrald Goldsmith, 10 February 1929, Los Angeles, California, USA, d. 21 July 2004, Beverly Hills, California, USA. A prolific composer for films and television, from the late 50s through to the new millennium. Besides studying music at the University of South Carolina (under Hungarian composer Miklos Rozsa), Goldsmith also took lessons in office practice and secured a job as a clerk/typist with CBS Television, before moving to the companys music department in Los Angeles in 1950. During the 50s, first as a staffer, and then as a freelancer, he wrote theme music for popular television series such as Gunsmoke, Have Gun Will Travel, Perry Mason, The Twilight Zone, Dr. Kildare, The Man From U.N.C.L.E. , and several more.
In the late 50s, Goldsmith started to compose for movies such as Black Patch and City Of Fear and, through the good auspices of film composer Alfred Newman, he came to prominence with his score for Lonely Are The Brave...
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Been working on a graphical update for my dissertation game, House Robot. The original sprites had just been placeholders really, so this time I made an effort and the sprite animations in particular look much better.
Month: February 2017
Dissertation Progress
This week I've been improving upon the initial draft of my lit review, by adding additional references to back up points made and to provide a comparing and contrasting of viewpoints in the subject areas.
I've also been working on my sprite creation skills, and I've managed to draw a much better character sprite for my dissertation and his walking animation spritesheets. My former attempts had literally been created as fast as possible to get something working to test my game, but now I'm putting proper effort in to improve the visual aspect of the game.


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Alisa Chearry is dressed all in black in her tights and stockings. She puts on a sexy and erotic show as she strips naked on her bed. Her fingers then move to her hairy pussy as she masturbates and orgasms.
Small Breasts, Hairy Armpits, Lingerie, Hairy Ass, Hairy Arms, Meaty Lips, Brunettes, Slim, Stockings, Striptease, Pale
Adobe Flash Player is required to play this movie.
Please click here to download it now.


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Crow religion is the indigenous religion of the Crow tribe, Native Americans of the Great Plains area of the United States. The medicine people of the tribe are known as Akbaalia ("healer").
The Mannegishi, also called little people, are bald humanoids with large eyes and tiny bodies. They are tricksters and may be similar to fairies.
Baaxpee is a spiritual power that can cause a person to mature, as well as unusual events or circumstances that force maturation. Baaxpee comes upon every human to make them into adults. After transformation, the changed are known as Xapaaliia.
Andiciopec is a warrior hero who is invincible to bullets.
|This page uses content from the English Wikipedia. The original article was at Crow religion. The list of authors can be seen in the page history.


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Saturday, April 15, 2017
Window Bird
Posted by Ariel | couturing at 4:13 PM 1 comments
Friday, March 24, 2017
Pink + White
3/18 - a recent minimal shoot with Kevin
Posted by Ariel | couturing at 8:30 AM 0 comments
Labels: hanging out, ootd
Thursday, January 5, 2017
Climate Change
Posted by Ariel | couturing at 12:00 PM 0 comments
Labels: ootd, Providence
Sunday, October 9, 2016
#shoplocal | Soap La Tea Da Haul
As I write this, I'm in the middle of enjoying my preferred methods of self care. I have my fall candle burning (Bath & Body Works' Warm Apple Pie is the holy grail), I have my glass of wine and my Ben & Jerry's, and it's raining outside. Life has actually been great lately, with much going on, but this is a much needed change of pace. Last month I stopped into a new bath and body shop downtown, Soap La Tea Da, and I've been waiting for just this mood/timing to share my thoughts.
black & white fuzzy cardigan, basic top: H&M / gray wash denim: Target / snake texture slip ons: GAP / mint crossbody: Old Navy
Serendipity, a beautiful mix of sweet and musky items
Posted by Ariel | couturing at 9:39 PM 0 comments
Labels: beauty, brands, haul, purchases, shop local
Saturday, October 8, 2016
Sometimes In The Fall
similar lace-up sweater and lace bralette from Nasty Gal / dark wash jeans: Forever 21 / pointed Chelsea boots: Old Navy
Posted by Ariel | couturing at 8:50 PM 0 comments
Labels: ootd
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24444 Seven Mile, Detroit 48219
See more homes for sale in Detroit, MI
This property has been Sold!
09/16/2016 at $450,000
Currently used as a church. Two properties make up this property (24444 and 24502 W. Seven Mile, Detroit). The 24444 Seven Mile building is approx. 7,200 square feet with a sanctuary seating 350, fellowship hall, kitchen, classrooms and offices. The 24502 Seven Mile building is approx. 7,000 square feet with a chapel seating 150, 5 classrooms, fellowship hall (with kitchen area) and offices. Each building has air conditioning, zero grade entrances (i.e. no steps) and handicap bathrooms. The buildings are in good condition with new roofs in 2015. The parking lot was replaced in 2005. The buildings have been completely renovated over the last 15 years (new windows, bathrooms, mechanical units, carpet, walls). The owner would prefer to sell for cash (giving buyer time to get a mortgage) but will consider a land contract for qualified buyers. Call agent to schedule a showing.
Property Information
- Architecture
- 1 Story
- County
- Wayne
- Above Grade SqFt
- 7,200
- Possession
- 90 Days
- Price/SqFt
- 62.5
School Information
- School District
- Detroit
- Current Use
- Church
- Comm. Office Space
- 7200
- Zoning
- Commercial, Office
- Water
- Municipal Water
- Sub Property Type
- Commercial
- Office Heat
- Central Air
- Plant Heat
- Forced Air
- Heating
- Forced Air, Natural Gas
Listing Video for 24444 Seven Mile, Detroit MI 48219
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The data relating to real estate for sale on this web site appears in part from the IDX programs of our Multiple Listing Services. Real Estate listings held by brokerage firms other than Real Estate One includes the name and address of the listing broker where available.
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IDX provided courtesy of Realcomp II Ltd. via Real Estate One and Realcomp II Ltd, © 2017 Realcomp II Ltd. Shareholders


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Salt absorption via alveolar epithelial Na+ channels (ENaC) is a critical step for maintaining an airspace free of flooding. Previously, we found that 8-(4-chlorophenylthio)-guanosine-3′,5′-cyclic monophosphate-Na (CPT-cGMP) activated native and heterologous ENaC. To investigate the potential pharmacological relevance, we applied this compound intratracheally to human lungs and found that ex vivo alveolar fluid clearance was increased significantly. Furthermore, this compound eliminated self-inhibition in human lung H441 cells and in oocytes expressing human αβγ but not δβγ channels. To further elucidate this novel mechanism, we constructed mutants abolishing (βΔV348 and γH233R) or augmenting (αY458A and γM432G) self-inhibition. The mutants eliminating self-inhibition lost their responses to CPT-cGMP, whereas those enhancing self-inhibition facilitated the stimulatory effects of this compound. CPT-cGMP was unable to activate a high Po mutant (βS520C) and plasmin proteolytically cleaved channels. Our data suggest that elimination of self-inhibition of αβγ ENaC may be a novel mechanism for CPT-cGMP to stimulate salt reabsorption in human lungs.
This work describes a novel mechanism for a broadly used 8-(4-chlorophenylthio)-guanosine-3′,5′-cyclic monophosphate-Na (CPT-cGMP) to activate lung epithelial sodium channels that govern alveolar fluid clearance. CPT-cGMP may be a potent reagent for removing edema fluid from injured lungs.
Epithelial Na+ channels (ENaC) in polarized absorptive tight epithelium are responsible for the transapical salt influx. Together with basolaterally located Na+/K+–ATPase, the vectorial solute/fluid transport pathway is crucial for maintaining luminal and body fluid volume (1–3). Five subunits have been cloned: α, β, γ, δ, and ε ENaC. Luminal impermeable reagents and hormones have been confirmed to regulate salt reabsorption in lung, kidney, and colon.
ENaC has long been proposed to function as a ligand-gated channel on the basis of observations of other ENaC/DEG family members (1, 4). Acid-sensing Na+ channels, a branch of the ENaC/DEG super gene family, are gated by external protons. Another branch of channels, termed FaNaC, are manipulated by FMRFamide and related tetrapeptides (5). With respect to ENaC channels, a number of luminal reagents, including para-chloromercuribenzoate; benzimidazoly-2-guanidinium; bumetanide; and H+, Zn2+, and Ni2+ ions, have been reported to alter external Na+ self-inhibition, a temperature-sensitive intrinsic phenomenon of ENaC (1, 4, 6–10). Recently, a small molecule (S6939), cpt-cAMP, halothane, glibenclamide, and extracellular chloride ions (Cl−) have been shown to act as ligands to regulate heterologous ENaC (11–16). Among these, halothane and Cl− ions may activate ENaC by eliminating Na+ self-inhibition (17, 18). We recently found that 8-(4-chlorophenylthio)-guanosine-3′,5′-cyclic monophosphate-Na (CPT-cGMP) stimulated human αβγ ENaC in oocytes in a PKG-independent and domain-specific manner (19). The underlying mechanisms are unknown.
Several ectodomains have been reported to modify self-inhibition by unknown mechanisms. Given that self-inhibition is governed by the extracellular Na+ concentrations, the extracellular loop was identified as the critical domain for self-inhibition of Xenopus ENaC by Babini and colleagues (20). By systematic screening mutagenesis, Sheng and coworkers found that external cysteine and histidine residues are essential for self-inhibition of murine ENaC (21, 22). This group recently discovered a number of key amino acid residues in the thumb domains that boosted this intrinsic phenomenon (23). The Cl− binding sites, which affect self-inhibition, are also located in the thumb domains (17). The finger and palm domains have been shown to be critical for external protons and furin to affect self-inhibition (13, 24). It has also been demonstrated that manipulations that result in a maximum increment in opening kinetics were capable of abolishing self-inhibition, for example, serine protease proteolysis and locking all channels in the open state (βS520C, a degenerin mutant). A mutation (αF61L) at the amino terminal of the protein, adjacent to the gating tract in the M1 domain, enhanced self-inhibition (25). Our current understanding of the nature of ENaC gating mechanisms provides no unequivocal answers to the question of how the aforementioned domains affect self-inhibition.
CPT-cGMP, but not parent cGMP, acutely activated human ENaC activity as an external ligand (19, 26). The aim of this study was to examine whether CPT-cGMP could be used as a pharmaceutical strategy to up-regulate alveolar fluid clearance (AFC) via stimulating ENaC and its underlying mechanisms. Our results demonstrate that intratracheally instilled CPT-cGMP significantly enhanced the rate of fluid reabsorption in human lungs. This compound only activated αβγ ENaC externally in a dose-dependent manner via blunting self-inhibition. Mutagenesis of the self-inhibition domains modulated this stimulatory effect.
The studies followed the guide principles of the Declaration of the People's Republic of China and were approved by the Ethics Committee of the China Medical University (CMU) at Shenyang, China. All patients were given oral and written informed consent forms. Human lung tissues were obtained during pulmonary resection surgeries of 30 patients with lung cancers (16 patients with lung squamous carcinoma and 14 patients with lung adenocarcinoma) at the First Affiliated Teaching Hospital of CMU (October 2009 to June 2010). There were no fibrous or emphysematous lesions as assessed by preoperative chest CT.
Human lung segments were prepared and AFC measurements were done as described previously (27, 28). Briefly, the segmental bronchus was occluded by a 10-Fr. balloon catheter immediately after removal of the lung, and occluded segments that were located furthest away from the focus of tumor were chosen. A warmed physiologic saline solution (20 ml; 37°C) containing 5% BSA with or without amiloride (1 mM) and/or CPT-GMP (0.5 mM) was instilled into the distal air spaces through the catheter. After instillation, the lungs were inflated with 100% oxygen at an airway pressure of 7 cm H2O. Alveolar fluid was aspirated 60 minutes after instillation. Aspirated alveolar fluid was centrifuged at 3,000 × g for 10 minutes, and the supernatant was obtained for measurement of protein concentrations. AFC values were calculated as follows (29): AFC = [(Vi − Vf)/Vi] × 100, where V is the volume of the instilled albumin solution (i) and the final alveolar fluid (f), and Vf = Vi × Pi/Pf, where P is the concentration of protein in the instilled albumin solution (i) and the final alveolar fluid (f).
Cell cGMP levels were examined with ELISA kits as described in the online supplement.
Wild-type human α, β, and γ ENaC cDNAs were a gift from Dr. Lingueglia (30). ENaC mutants were constructed as described previously (31). Preparation of oocytes and the two-electrode voltage clamp studies were performed as described in the online supplement (31).
To study the self-inhibition, a bath solution (ND1) with a low concentration of Na+ ions (1 mM) was used (the 95 mM Na+ ions in regular ND96 medium was substituted with equal molar N-methyl-d-glucamine). To elicit self-inhibition, oocytes were held at −60 mV continuously while the bath solutions were switched quickly from ND1 and ND96 solutions, controlled with a SF-77B Perfusion Fast-Step (Warner Ins., Hamden, CT) fluidic exchange system and software pCLAMP as previously described (32, 33). CPT-cGMP (AXXORA, LLC, San Diego, CA) stock solution (50 mM) was prepared in water and stored at −20°C. MTSET (Toronto Research Chemicals, Downsview, ON, Canada) was freshly prepared every 10 minutes.
Whole-cell and single-channel patch clamp recordings in H441 cells were performed as described in the online supplement (26).
All results are presented as mean ± SE. Dose-response curves were fitted to the Hill equation. One-way ANOVA computations were used to analyze the difference of the means for normally distributed data. P < 0.05 was considered as significant.
CPT-cGMP is a cell-permeable compound. Its concentration within human lungs is reduced due to its entrance into alveolar epithelial and nonepithelial cells. We reported that a median effective concentration (EC50) value of 147 μM was required for CPT-cGMP to activate ENaC activity in H441 cells and that the apparent saturated dose was 1 mM (26). In addition, up to 2 mM cGMP analog was applied to primary lung epithelial cells in vitro for ENaC studies (34, 35). As an external ligand, CPT-cGMP was required to maintain an effective dose at least two times above its EC50 value. Therefore, we applied 200 μM of CPT-cGMP to H441 cells and oocytes and 500 μM CPT-cGMP to lungs.
To examine the potential effects of cGMP on fluid resolution in distal lung, we measured ex vivo AFC in isolated human lung lobes. Intratracheally delivered CPT-cGMP markedly increased the AFC value (n = 5–15) (Figure 1A). Moreover, CPT-cGMP stimulated fluid resolution in human lungs ex vivo through augmented ENaC activity, as revealed by amiloride-inhibitable AFC fraction (P < 0.05) (Figure 1B).
To test the hypothesis that CPT-cGMP activated native ENaC by blunting self-inhibition, we studied the effects of CPT-cGMP on the self-inhibition of native ENaC in H441 cells, a human lung epithelial cell line (Figure 2A). Analogous to the effects on heterologous human α-containing channels, CPT-cGMP significantly elevated the sustained/maximal current ratio (Figure 2B). In sharp contrast, in the presence of amiloride, CPT-cGMP did not evoke currents associated with non-ENaC channels (Figure 2A, right panel).
The α and δ subunits are expressed in human lung tissues and primary alveolar type II cells (26, 32). δ ENaC–like channels have been functionally detected in human nasal epithelial cells (36). We previously found that CPT-cGMP activated δαβγ ENaC in oocytes (26). Here we further distinguished the responses of the αβγ and δβγ channels to CPT-cGMP (Figure 3). CPT-cGMP evoked inward and outward currents associated with αβγ but not δβγ channels (Figures 3A and 3B). The increment in αβγ ENaC activity was more than 3-fold (Figure 3C). The EC50 values were 71 ± 2 μM and 95 ± 4 μM, respectively, for currents at −100 and +80 mV (Figure 3D).
Our previous studies found that heterologous ENaC expressed in oocytes may not be regulated by PKG (19). In PKG-deficient cells, the extent of compound stimulation of ENaC was identical to those transfected with scramble siRNA. We substantiated these observations by single-channel recordings. In a cell-free mode that lacks cytosolic PKG signaling molecules, single-channel activity was elevated approximately 3-fold by CPT-cGMP in outside-out patches (Figures 3E and 3F). However, the single-channel activity appeared reduced when CPT-cGMP was applied to cell-attached patches (Figure 3G). Taken together, our results show that heterologous ENaC expressed in oocytes is not regulated by cGMP/PKG pathway. It is reminiscent of the well known fact that ENaC expressed in oocytes is not cAMP/PKA-dependent. We subsequently took the advantage of this expression model to study the mechanisms beyond PKG.
To corroborate the observations in H441 cells, we investigated the effects of CPT-cGMP on self-inhibition associated with human αβγ ENaC in oocytes. The first three sweeps were recorded in the absence of CPT-cGMP as controls (Figure 4A). As anticipated for the self-inhibition, approximately half of the maximal current was the sustained current after fast fluidic exchange (Figure 4A). CPT-cGMP (0.2 mM) stimulated the maximal and the sustained currents reversibly. In the presence of this compound, the sustained/maximal current ratio increased significantly (P < 0.01) (Figure 4B). In contrast to αβγ ENaC, δβγ ENaC showed a slight self-inhibition. Moreover, CPT-cGMP did not alter the kinetics of this process in cells expressing δβγ ENaC (Figure 4C).
Because CPT-cGMP regulates self-inhibition, mutation of the self-inhibition domains should modulate its effects. We constructed two self-inhibition–abolishing mutants, βΔV348 and γH233R, as previously reported for murine ENaC (7, 17). The responses of these mutants to CPT-cGMP were almost completely depressed (Figure 5A). In contrast, αβγ ENaC showed a more than 3-fold increment in the maximal currents after CPT-cGMP perfusion (Figure 5C).
A series of amino acid residues within the thumb domains, which amplified self-inhibition, have recently been identified (23). Based on the observation that the self-inhibition–abolishing mutant (γH233R) was not sensitive to CPT-cGMP (Figure 5A), we postulated that the self-inhibition boosting mutants (αY458A and γM432G) might be more sensitive to CPT-cGMP and found this to be the case experimentally. The responses to CPT-cGMP (ICPT-cGMP/Ibasal) of αY458A (P < 0.01) and αY458AγM432G (P < 0.001) were increased significantly (Figures 5B and 5D).
Elimination of self-inhibition by CPT-cGMP may result in an increment in open probability. We therefore measured the ability of CPT-cGMP to activate DEG mutant channels, which were already fully open (βS520C). CPT-cGMP reversibly activated αβS520Cγ in the absence of MTSET, suggesting that this mutant responds to CPT-cGMP in the same manner as wild-type channels (19). However, reapplication of the same dose of CPT-cGMP, after all channels were fully opened and clamped by MTSET, could not duplicate the stimulation (Figure 6A). The current ratio before and after addition of CPT-GMP was close to 1.0 for fully open channels, significantly less than that in the absence of MTSET for αβS520Cγ (P < 0.001) (Figure 6B).
The cGMP level in lung instilled with CPT-cGMP was 8.1 ± 2.7 pmol/mg protein, which was much greater than the level in control lungs (0.2 ± 0.05 pmol/mg protein; n = 6; P < 0.01) (Figure 7A). Perfusion of CPT-cGMP elevated the intracellular cGMP level in H441 cells from 25.5 ± 8.4 to 327.0 ± 74.6 pmol/mg protein (P < 0.01; n = 10). Similarly, an increment in cGMP content in oocytes exposed to CPT-cGMP was seen (from 0.5 ± 0.1 to 11.8 ± 2.9 pmol/mg protein; P < 0.01; n = 100). The compound increased cell cGMP levels 54-, 12-, and 24-fold, respectively, in lungs, H441 cells, and oocytes. The diverse responses may be due to various exposing periods. In addition, the yield of cell protein may vary between these models.
Our results reveal a novel mechanism for CPT-cGMP to stimulate ENaC in human lungs; that is, elimination of external Na+ self-inhibition of native ENaC, an intrinsic feature of the channels. However, mechanistic studies found that this compound cannot up-regulate two self-inhibition abolishing mutants (βΔV348 and γH233R) or a fully opened channel (βS520C). In sharp contrast, mutants boosting self-inhibition displayed a greater response to CPT-cGMP. Although CPT-cGMP does not regulate heterologous δβγ ENaC in oocytes, we cannot exclude the potential regulation of native δ ENaC–containing channels by this compound because ENaC channels expressed in oocytes do not respond to cAMP/PKA and cGMP/PKG pathways.
Two amiloride-sensitive ion transport systems may contribute to the increment in AFC in human lungs instilled with CPT-cGMP. First, apically located ENaC can be regulated by the NO/cGMP/PKG signaling pathway (37, 38). In vitro studies on the regulation of Na+ transport by cGMP across confluent monolayers of cultured rat type II alveolar (ATII) cells have led to contradictory results. cGMP did not alter the short-circuit current (Isc) across rat ATII monolayers (39), supporting a previous study using dome formation as a parameter for active salt and water transport (40). In contrast, cGMP, as well as NO, increased Isc and 22Na influx in tracheal and distal lung epithelia (41, 42). In addition, regulation of Na+ channel activity in A549 and rat ATII cells, as revealed by patch clamp studies, is not consistent. Jain and colleagues reported that cGMP and GSNO significantly decreased single-channel activity in rat ATII cells (34). A stimulatory effect of cGMP has been reported in the same cells (43). Furthermore, different responses of whole-cell Na+ conductance to cGMP and GSNO in A549 cells were published by three independent groups (44–46). Cyclic GMP stimulated amphibian ENaC in urinary bladder epithelium (47, 48). We recently found that CPT-cGMP stimulated human but not murine ENaC (19). The biophysical features of ENaC channels depended on the culture conditions (49, 50). Species- and culture dependence of ENaC properties and the strategies used for elevating cell cGMP content, including NO donors and PKG isoform-specific cGMP analogs, may contribute to these divergent observations. Second, CPT-cGMP may enhance AFC in human lungs through activating cyclic nucleotide-gated Na+ channels. Cyclic GMP increased AFC (30–70%) across rat, rabbit, and sheep adult lungs (51–54) at least partially by activating cyclic nucleotide-gated Na+ channels.
CPT-cGMP also increased amiloride-insensitive AFC in human lungs, possibly due to cGMP-sensitive CFTR and K+ channels. Classical studies clearly demonstrated that CFTR played an essential role in lung liquid reabsorption (55, 56). CFTR was activated by cGMP via PKG isoform II (57, 58). In addition, cGMP may accelerate the K+ recycling across basolateral membrane and may indirectly facilitate transalveolar salt transport (29). We cannot exclude the contribution of these non-ENaC pathways and others at the high dose of CPT-cGMP applied to lungs. When CPT-cGMP is applied luminally (extracellularly), it serves as an external ligand to activate ENaC via releasing self-inhibition of ENaC and then acts as a signal molecule in cytosol to stimulate PKG (Figure 7B). Eventually, the cGMP-sensitive pathways, including CFTR, K channels, and ENaC, are activated to expedite AFC coordinately.
Beyond the cGMP/PKG signal pathway, our data suggest that CPT-cGMP may activate human αβγ ENaC extracellularly by serving as an ENaC ligand, particularly when applied at a concentration above 100 μM. CPT-cGMP activated single-channel activity in outside-out but not cell-attached patches, which separate clamped channels within the pipette from bath CPT-cGMP (19). Even though CPT-cGMP is a cell permeable–specific PKGII activator with an EC50 value in the micromolar range, the time course for activating ENaC in the order of seconds was not supportive of the involvement of this pathway. The EC50 value for CPT-cGMP to rapidly and reversibly activate ENaC is 15-fold greater (71 μM) than that required to activate PKGII (4.6 μM) (59). More specific membrane-permeable analogs of PKGII activators did not stimulate ENaC in a similar manner (19). In addition, specific chlorophenylthio moiety is required to acutely activate ENaC (16, 19).
The following lines of evidence support that CPT-cGMP leads to the relief of the external Na+ self-inhibition of ENaC. First, CPT-cGMP reversibly reduces the declining rate of the maximal current, a hallmark of the release of self-inhibition (6). Second, the sustained/maximal current ratio, another methodology for evaluating self-inhibition, is not altered in peptidase (plasmin)-cleaved channels. Third, and the most direct evidence, is the absence of CPT-cGMP–induced activation in the self-inhibition abolishing mutants βΔV348 and γH233R. Finally, the self-inhibition boosting mutants augment CPT-cGMP–activated current. These results suggest that CPT-cGMP abolishes the Na+ mediated self-inhibition process.
What is the physiological and pharmacological relevance? Under physiological conditions, cytosolic cGMP may be secreted through nucleotide transporters such as CFTR and multidrug resistance proteins (60, 61). In human plasma, the cGMP level is 6 nM (62). In human bronchoalveolar lavage, it is up to 3-fold higher (63). Because cGMP in lung fluid regulates ENaC as autocrine and paracrine, the anticipated concentration at the surface of apical membrane is much greater than the average content in lavage (Figure 7B). As shown by the dose–response curve, this compound abrogates self-inhibition at micromolar level.
Regarding the potential pharmaceutical significance, the concentration of cGMP analogs clinically delivered into patients was up to 1 mg/kg (64, 65). Numerous studies applied cGMP reagents (from 100 μM to 2 mM) to lung tissues and primary alveolar epithelial cells (34, 35, 43). Aspiration of CPT-cGMP may therefore acutely ameliorate the severity of edematous lung injury by two distinct mechanisms for ENaC activation: activation of the cGMP/PKG signal pathways and relief of self-inhibition of ENaC.
The authors thank Drs. Sadis Matalon, Michael Matthay, and Mark Atkinson for helpful discussions, and Raul Molina for technical assistance.
Supported by NIH grants HL87017 and HL095435 (H-L.J.) and China National Natural Science Foundation grant 30971181 (H.-G.N.).
This article has an online supplement, which is accessible from this issue's table of contents at www.atsjouranals.org
Originally Published in Press as DOI: 10.1165/rcmb.2011-0004OC on May 11, 2011
Author Disclosure: None of the authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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One of the record trying interval in yesteryear that grouping has of all time encountered is the 21st time period. Have you ever wondered why the spa and eudaemonia business is now vigorous booming? People impoverishment to have a rest and calm their worn article and drained mind. To be fair, not all accent is bad because scientists deem that extensive amount of accent prepares you for the challenges you may clash during the day. Now we cognize that too such of thing is unhygienic so learn to tame and authority stress earlier it takes calmness of you.
Relax. Take a profound bodily process and say this to yourself ten present time "everything will be good." After this, perspicuous your mind from all the cobwebs and absorption on what necessarily to be through with. Cramming for an communication the subsequent day or minding your place of business mates who couldn't vigilance smaller amount but to dig into their business office mate's esoteric lives won't assistance. Learn to detach yourself from the noises and nerve-wracking situations around you.
Stop aggressive yourself. Trying too problematical to craft both ends fitting is not a flawless trial at all. If you grain weathered out already, clutch a split. Since when did resting turn a crime? Pushing yourself to the limitations will just mar your eudaimonia. Do yourself a favor, snap your natural object and heed whichever slapdash. Get a obedient physiological condition because need of catnap meet aggravates prosody.Post ads:
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probabilitynoun [ C or U ]uk /ˌprɒb.əˈbɪl.ə.ti/ us /ˌprɑː.bəˈbɪl.ə.t̬i/
C1 the level of possibility of something happening or being true:
What is the probability of winning?
Until yesterday, the project was just a possibility, but now it has become a real probability (= it is likely to happen).
in all probability
Thesaurus: sinónimos y palabras relacionadas


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This topic was created during version 2.1.
The latest version is 7.5.00101.
3 Replies
Jun 15, 2008 at 8:14 UTC
Hi Nate,
Spiceworks doesn't have CPU monitoring. Do you have the email section turned for the monitors? (just goto Settings->Monitors and make sure the email box is checked for the monitors)
Jun 16, 2008 at 10:10 UTC
1st Post
Sorry, I misspoke about the CPU monitoring. That is from another notification system.
I set up the SW system to alert me for several different conditions. The test email went out fine. However, the various conditions I have set to alert me are not coming through. Is there a log or test I can run? I have no idea or indication of anything going wrong, but I do not get any notifications. At times, i do get a weekly summary report. (I don't even know how that is happening, since I have seen any configuration to send me a weekly summary report.)
Jun 16, 2008 at 2:19 UTC
I am having this same issue. I can get the smtp test email but none of the notifications are coming through. I am set to receive alerts and I have the email part of the alerats turned on.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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Community relations is often described as public relations at the local level. Its main goal is to establish relationships with a community where an organization operates. Vice presidents of community relations handle much of a company's communications, informing the local public of products, services and programs of their employer. With the help of other PR professionals, they continually evaluate the local attitude, basing PR campaigns on these findings. If, for example, attitudes are negative toward a company, a VP may choose to support a local program, such as an urban renewal or education project, and then release information on the activity to the public. The goodwill can go a long way to improve the image of that company and thereby its bottom line.
Salary Ranges
Some companies choose to keep community relations in-house, while others contract out for these services. A survey by The Creative Group, a national marketing and PR recruiter, found that in-house VPs of public relations earned $115,750 to $190,500 per year as of 2013. Those working for PR agencies, on the other hand, brought home $114,000 to $194,500 per year.
Local Variances
As with any career, earnings vary by location, largely due to the cost of living. For example, salaries are generally 8 percent higher in Phoenix, Arizona, than nationally. An in-house VP of PR in this area could expect to earn $125,010 to $205,740 per year. In Minneapolis, Minnesota, salaries are 5.5 percent higher than the national average, bringing salaries up to $122,116 to $200,978 for in-house VPs of PR. In Charleston, South Carolina, salaries are roughly 8 percent lower than the national average with salaries ranging from $106,490 to $175,260 annually.
Contributing Factors
The six-figures salaries are at least partly due to education, as most vice presidents have advanced degrees. In general, VPs of community relations hold a master's in public relations or marketing, a master's in business administration or an MBA with a concentration in public relations. Also, most VPs of PR have years of experience, working in other capacities of community relations, such as PR director, media director, PR manager or communications specialist.
Career Outlook
Though the U.S. Bureau of Labor Statistics (BLS) believes employment for VPs in general will grow by just 5 percent from 2010 to 2020, growth varies greatly by industry, and future prospects for VPs in community relations may be greater. Community relations is essential to almost all businesses, as public opinion can impact customer loyalty and purchase behavior, which inevitably affects profitability. In fact, the BLS expects job opportunities for PR specialists to grow by 23 percent through 2020, adding more than 58,000 positions to the job market. So, VPs of community relations may experience similar job opportunities during this same period of time.
Photo Credits
- Siri Stafford/Digital Vision/Getty Images


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Kentucky has so many offensive weapons at its disposal that sometimes it's difficult for opponents to figure out who to focus on.
The deep and balanced Wildcats take on Cleveland State in the Keightley Classic on Monday night at Rupp Arena.
Third-ranked Kentucky (4-1) has had a different leading scorer in each of the past three games, and four Wildcats are averaging at least 11.0 points, led by Julius Randle with 20.8.
Eight Kentucky players are averaging at least 5.6.
''We have a lot people who score, so if it's somebody's night we just try to give him the ball as much as we can," said freshman forward James Young, who had a team-high 26 points in a 105-76 victory over Texas-Arlington on Tuesday.
The Wildcats (4-1) may be an offensive powerhouse, but coach John Calipari wants his young roster to focus more on the other end of the floor. Kentucky starts five freshmen.
"We're trying to get them to play through a whole possession, stay in a stance," Calipari said. "Someone said, 'Wow, you guys got beat on the dribble.' Yeah, if you're standing straight up and down, it's pretty easy to get beat on the dribble. So we did a lot of things of keeping them in a stance. But again, when I watched the tape there's just not the effort."
The Wildcats do rank among the nation's leaders in rebounding at 49.0 per game. Against Texas-Arlington, Randle and Willie Cauley-Stein each had 10 boards, and Kentucky forced 16 turnovers which led to 24 points.
Still, the Mavericks shot 42.1 percent from 3-point range and their speed on the perimeter seemed to cause problems for Kentucky's backcourt.
Calipari thought his inexperienced team might have played down to its perceived level of competition.
"If a team's effort level is far beyond yours, it will smash a talented group. Just will," he said. "A less talented team that just fights like crazy will beat the talented team. So, my job right now is to get these guys to understand how hard they've got to play, what it's got to look like, and we're just not there."
Center Dakari Johnson, who had eight points and eight rebounds in 13 minutes, said the players are listening to Calipari.
"We're just trying to get better on the things we need to work on that we saw in the past games," Johnson said. "And that's just playing defense and getting stops."
Cleveland State (3-2) used a balanced attack to knock off Robert Morris 87-74 on Saturday. Only seven Vikings players scored but six reached double figures, led by Bryn Forbes with 18 points.
The Vikings fell behind 11-2 but scored 54 points in the second half to pull away.
Forbes leads Cleveland State with 19.6 points per game.
In the schools' only meeting, Kentucky defeated Cleveland State 73-49 on Nov. 24, 2009. Kentucky is 15-4 all-time against the Horizon League.


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|Jack (clinic patient)
|Tyrace Richardson
|First Appearance
|Needle in a Haystack
This article is about the young clinic patient in Needle in a Haystack. For the patient in Larger than Life see Jack.
Jack was a young clinic patient in the episode Needle in a Haystack. He was portrayed by actor Tyrace Richardson.
That morning, Jack told his mother Kate that he was too sick to go to school because he had a sore throat. She figured he was malingering and threatened to take him to the doctor if he didn't go to school. When he refused to go to school, she took him to the clinic and they were seen by Gregory House who did a quick examination and found nothing wrong. The mother told Dr. House she suspected Jack was lying about being sick so she threatened to take him to the doctor. Dr. House told Kate that children often get scared of going to doctors because their parents treat it as a threat and decided to teach her a lession. He grabbed a syringe full of saline. When Kate asked what he was going to do, Dr. House told her that he was going to do an intra-muscular injection - harmless but very painful. He said that would teach the kid not to lie about being sick. Kate was astounded and Dr. House turned to Jack and asked if his mother was always this much of an idiot. He nodded silently. Feeling his job was done, he left the room.


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Stochastic Scheduling of Linear Construction Sitesby Joachim Dressler, (A.M.ASCE), Postdoctoral Fellow; Dept. of Civ. Engrg., Stanford Univ., Stanford, CA,
Serial Information: Journal of the Construction Division, 1974, Vol. 100, Issue 4, Pg. 571-587
Document Type: Journal Paper
Essential basic data of scheduling linear construction sites are subject to stochastically variable influence factors, e.g., weather conditions. To evaluate economical low-cost alternatives which determine the production sequence of segments of a linear site through a projected construction time, a mathematical model is developed which is formulated as a two-stage stochastic linear programming problem and can be solved by standard linear programming methods. Criteria for interpretation and evaluation of model solutions in terms of a time-velocity diagram are derived and illustrated with a simple example problem. By means of stability analysis, risk factors and probability distributions of project duration and cost can be obtained for different construction alternatives to prepare a final decision. It is emphasized that the methodology presented is not seen as an approach to determine the optimal decision, but rather as a tool to facilitate decision making, since this ultimately relies on practical engineering judgment.
Subject Headings: Construction sites | Linear functions | Stochastic processes | Scheduling | Construction methods | Risk management | Mathematical models | Computer programming | Weather forecasting
Services: Buy this book/Buy this article
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Lullaby, Fatman
Print advertisment created by Y&R, India for Koolfoam Mattress, within the category: House, Garden.
Soft mattresses for sound sleep
Creative Directors: Anisha Sarin, Sanket Pathare
Art Director / Copywriter: Prasad Jindam
Illustrator: Nishikant Palande
Remember Ramayana
Out Standing Work
Designer Don't Do Different Things
They Do Things Differently
and u were working there too..let other praise the work too....thanks for reminding ramayana and all....
any way very good work indeed...
I guess this is from one of their old stories.
these are very good ads in fact, in fact good "bharatiya ads...those who pointing problems should come out of marylin monroe, john lennon....its a good effort actually to bring out not so "omg" concepts but something very relevant indian themes.....art is superb undoubtedly
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FUNDS WATCH; Roaming Among Stocks, Bonds and Cash
By Carole Gould
Published: July 23, 1994
Asset allocation funds can shift among stocks, bonds and cash, and the ones that performed best over the last three years have taken full advantage of their liberal charter.
Most of the winners use a value approach to picking stocks, scouring the world for issues they consider cheap relative to what they believe the companies are worth. Many are contrarian, and some, very opportunistic. Sogen International, for example, was helped last year by its big position in gold, and both Sogen and Merrill Lynch Global Allocation built big cash cushions in 1994 that sheltered them from stock and bond declines.
These funds are very different from traditional asset allocation funds, which made decisions based on such macroeconomic factors as worldwide interest rates or the gross domestic product in various countries. The group started after the 1987 stock market crash. But the original funds did not perform well, and the group began evolving two or three years ago.
Asset allocation funds can invest in anything, anywhere, making them a good choice for people who do not want to build their own portfolios of mutual funds, said Eileen M. Sanders, an analyst with Morningstar Inc., in Chicago.


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All Christians follow the same God
- Loraine Cameron
- 2 years ago
- Views:
1 What happens at Church All Christians follow the same God Written and photographed by Daniel Giles 1
2 All Christians follow the same God 2
3 My family and I may go to the same church most times. 3
4 Sometimes, we may go on holiday far away from our church. 4
5 This means that we may visit another church. 5
6 Sometimes, we may be invited to another church for a special occasion. A wedding is a special occasion. Photo Richard Gibbs 6
7 A baptism is also a special occasion. People can be baptised as babies, children and adults. Children are usually baptised over a baptismal font. 7
8 Adults can also be baptised over a baptismal font. 8
9 Some people are baptised by immersion. The baptism may happen in a small pool. Photos Richard Gibbs 9
10 Church may not always be held in church buildings (used only as a church). Other buildings such as community halls can be used as a church. 10
11 Photo Richard Gibbs Church may be celebrated outside, especially on special occasions. 11
12 Although churches can be very different, they are all there for people to worship God. 12
13 What is always the same is people coming together to worship God through song. 13
14 What is always the same is people coming together to worship God through prayer. 14
15 What is always the same is people learning about God from the Bible. 15
16 What is always the same is people receiving Communion. 16
17 I know that whether things are similar or not, people come together to worship God at any church. 17
18 Notes for parents This resource has been created to assist people with Autism Spectrum Disorders (ASDs) and their peers in understanding the social situation of attending church services. This booklet focusses upon abstract religious concepts (such as prayer) and the structure of church routines. The underlying theme is that while churches may conduct their services in many ways, they exist for a single purpose: to know, love and serve God. This resource is suitable for preparing a person with an ASD to confidently attend a church service. 18
19 About the author/designer Photo Michael Nix The series What Happens in Church has been created by Daniel Giles an honours student at La Trobe University (Bendigo) and an individual living with an Autism Spectrum Disorder (ASD). This project has been inspired by his various passions of: graphic design, photography, assisting other people with ASDs and most importantly, living out his faith in God. Daniel is pictured above with another project he created for people with ASDs titled Facing Our Feelings. 19
20 Acknowledgements This project is dedicated to the God who desires for people with ASDs to know, love and serve Him (as He does of all humanity). This resource could not have been produced without Him. God has also worked through a number of people listed below (and those who are not mentioned here) to help produce this project. Thanks to people who have helped me realise my dream, including: Graphic Design Staff La Trobe University, Bendigo (especially for their invaluable support during my studies) Lindsey Gale Coordinator of CBM Australia s Luke14 Program (and her dedication towards including people with disabilities into church communities) People from both theological and disability-support backgrounds who have assisted in proofreading my work and providing guidance from a professional perspective, including: Mrs Tricia Blanks Chaplaincy Coordinator La Trobe University, Bendigo The following people and church communities who have kindly provided venues, people and practical support for my photography, including: St Matthew s Anglican Parish, Panton Hill Donvale Presbyterian Church St John s Anglican Parish, Diamond Creek Faith and Light Assisi Community, Bendigo (Photos taken at St Joseph s Catholic Parish, Quarry Hill) St Luke s Anglican Parish, Frankston Kennington Catholic Parish (Bendigo) Sacred Heart Cathedral Parish (Bendigo) Ms Leanne Egan and Mr Timothy Algie Other people for providing photos, including: Mr Michael Nix (assisted by Miss Elizabeth Flemming) Mr Richard Gibbs Staff from Catholic Education Sandhurst Mrs Cheryl Sullivan Ms Meredith Ward Copyright Insightful Design 2012 E: W: This publication may be printed or photocopied in its original form exclusively for personal use or use within church communities. Not for resale or commercial use. All other rights reserved. 20
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text:
by: Anshi
Story Structure
Setting: Canadian Wilderness
Main Character: Brian Robeson
Secondary Characters: Pilot, Terry, and Brain's mom
Theme: Survival & Hope
Genre: Adventure Fiction
Point of View: Third Person Limited
Flashback is when the author goes back in the story to tell you something you didn't know.
In the story Gary Paulsen uses flashback to tell you about the characters background and why he is on the plane, the secret, the divorce, and his hunger.
Some example of flashbacks are: the food smells because of his hunger.
Hatchet is a story about a 13 year old boy named Brian. Devastated by his parents divorce and taunted by his mother's secret. Brian was on his way to visit his dad in Canada. Mid-way of the flight, the Cessna's pilot had an heart attack and died. Then, the plane crashed into a L - shaped lake. Now, after all he has been through, Brian has to survive in the wilderness by himself and with a hatchet!!!
Personification & Symbolism
Personification is when you put human qualities on a non-human object. Gary Paulsen uses personification to add more characters to the story. One example of personification is:
Symbolism is when you symbolize an item. Gary Paulsen uses symbolism to give the story life because the story only has one character and it makes the story provoking, breath-taking and suspenseful. The hatchet to Brian symbolizes bravery, power, survival, strength.
Internal conflicts are conflicts that happen inside of you. One internal conflict Brian faced is the secret. This is an internal conflict because he was only hurt mentally.
External conflicts are conflicts which happen physically to you. One external conflict Brian faced was the tornado because everything of his got ruined and he had to rebuild everything. This an external conflict because he was hurt physically.
The problem is Brian is stuck in the wilderness with an hatchet.
Brian solved his problem because he remembered the pilot saying there was a survival kit at the back of the plane. So, Brian built a raft and got the survival kit. In the survival kit he found an emergency transmitter and pressed a button and a fur buyer came to rescue him.
Plot: Problem & Resolution
Brian remembered the pilot mention a survival pack in the tail of the plane. In it he found many things including an emergency transmitter. Then, he got rescued by a fur buyer.
Brian eventually visited his dad in Canada. He tried to tell his dad about the secret, many times but he never did.
Brian had spent 54 days in the wilderness. During the time he had lost 17% of his body fat and later gained back 6%.
Repetitive language is to remind the reader about something.
An example of repetitive language is the secret because the author keeps on reminding you about the secret because it's really important to the story.
Suspense is when the book is so exiting you have to read more.
Gary Paulsen uses suspense to put you in the characters shoes.
One example of suspense is: "The hatchet sailed across the cave, and it missed." This is an example of suspense because the reader wants to read more.
Repetitive Language
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Plaza Vistaon 1 June 2014
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