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C.R. Girija1*, Prashantha Karunakar1, Chetan S Poojari1, Noor Shahina Begum2and Akheel Ahmed Syed3
1Department of Chemistry, SSMRV College, 4thT Block, Jayanagar, Bangalore-560041, India.
2Department of Studies in Chemistry, Bangalore University, Central College Campus, Bangalore-560001, India.
3Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore-570006, India.
Received Date: May 25, 2010; Accepted Date: June 26, 2010; Published June 26, 2010
Citation: Girija CR, Karunakar P, Poojari CS, Begum NS, Syed AA (2010) Molecular Docking Studies of Curcumin Derivatives with Multiple Protein Targets for Procarcinogen Activating Enzyme Inhibition. J Proteomics Bioinform 3: 200-203. doi: 10.4172/jpb.1000140
Copyright: © 2010 Girija CR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of Proteomics & Bioinformatics
Curcumin derivatives which are very potent antioxidant, free radical scavenger and known inhibitor of dioxygenases have been extensively studied to explore their potential utilization in chemoprevention. The main objective of the present work is to perform a docking analysis of curcumin derivatives: Tetrahydrocurcumin (THC), Bisdemethoxy curcumin (BDC). Docking studies of these were performed using GOLD and AutoDock into a few well validated targets of anticancer therapy (COX-2, PhenolsulphoTransferases, Matrix metalloproteinases (MMPs), P450 and TNF-alpha). A good correlation was observed in binding affinity of THC and BDC against the targets indicating these derivatives are potent procarcinogen activating enzyme inhibitors.
Docking; Procarcinogen inhibitors; Anticancer therapy targets; Tetrahydrocurcumin; Bisdemethoxycurcumin
Curcumin [1,7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene- 3,5-Dione] is the major component of the Curcumin species used as a yellow coloring and flavoring agent in foods. Curcumin has shown anti-carcinogenic activity in animals as indicated by its ability to block colon tumor initiation by azoxymethane and skin tumor promotion induced by phorbol ester TPA. It is proposed that curcumin may suppress tumor promotion by blocking signal transduction pathways in the target cells (Lin and Lin-Shiau, 2001). Curcumin has been demonstrated to have potent antioxidant (Kunchandy and Rao, 1990; Subramanian et al., 1994; Sreejayan and Rao, 1994), anti-inflammatory activity (Huang et al., 1988; Conney et al., 1991; Huang et al., 1997; Liu et al., 1993), to inhibit the carcinogen-DNA adduct (Conney et al., 1991) and tumorigenesis in several animal models (Huang et al., 1992; Huang et al., 1994; Huang et al., 1995; Rao et al., 1995).
As a part of our continuing program to discover procarcinogen inhibitory compounds, curcumin derivatives were studied. Tetrahydrocurcumin(THC) and bisdemethoxycurcumin(BDC) Figure 1, are the reduced form of curcumin, derived from curcuminoids and can also be extracted from the roots of Curcuma longa, commonly called turmeric root (Govindarajan, 1980). Tetrahydrocurcuminoids are colorless unlike bisdemethoxycurcumin an yellow curcuminoid which are used in color-free foods and cosmetic products. An antioxidant used in a cosmetic application should have the capability of efficiently quenching any radicals on the surface of the skin. In this context, compound THC displays superior free-radical scavenging ability and also exhibits antioxidant, anti-inflammatory and skinlightening actions (Sugiyama et al., 1996; Rao et al., 1982) and anticancer activity (Huang et al., 1995). It is thought that the p-hydroxy functional groups in THC are responsible for the antioxidant activity and keto groups are responsible for the chemopreventive action of the compound (Rao et al., 1995; Halliwell and Gutteridge, 1985). The crystal structures (Figure 2a and Figure 2b) of THC abd BDC have been determined using X-ray crystallography and the results have been extrapolated for docking analysis (Girija et al., 2004).
The concept of docking is important in the study of various properties associated with protein-ligand interactions such as binding energy, geometry complementarity, electron distribution, hydrogen bond donor acceptor properties, hydrophobicity and polarizability. Since molecules in nature have a tendency to be found in their low energy form, the final configuration should also be of low energy (Pyne and Gayathri, 2005). Understanding these properties is crucial in rationale design of potent inhibitors.
Preparation of ligand structures
The small-molecule topology generator Dundee PRODRG 2 server (Schuttelkopf and van Aalten, 2004) is used for ligand optimization, a tool for high-throughput crystallography of protein-ligand complexes which takes input from existing coordinates or various two-dimensional formats and automatically generates coordinates and molecular topologies suitable for X-ray refinement of proteinligand complexes. CambridgeSoft– ChemOffice 6.0.1(CambridgeSoft. com, Cambridge, MA, USA) tool used for physicochemical properties of THC and BDC (Table 1).
|Physicochemical Properties
|Boiling Point
|Melting Point
|Critical Volume
|1075.5 Cm.Cm.Cm/mol
|887.5 Cm.Cm.Cm/mol
|Critical Temperature
|Critical Pressure
|20.437 Bar
|29.155 Bar
|Crippens fragmentation method ( Crippens, 1987)
|102.09 Cm.Cm.Cm/mol
|91.30 Cm.Cm.Cm/mol
|Heat of Formation
|-870.87 KJ/mol
|-307.77 KJ/mol
|Gibbs Energy
|-445.58 KJ/mol
|-72.72 KJ/mol
|Ideal gas thermal capacity
|438.08 J/mol.K
|329.49 J/mol.K
|Henry's Law constant
|18.2264 log
|17.0884 log
|Connolly Accessible Area
|662.529 (Å) squared
|574.346 (Å) squared
|Connolly Molecular Area
|360.435 (Å) squared
|301.153 (Å) squared
|Connolly Solvent-Excluded Area
|307.909 (Å) cubed
|244.895 (Å) cubed
|Molecular Formula
|Molecular Weight
|372.41 a.m.u
|308.33 a.m.u
|Bend Energy
|17.923 Kcal/mol
|8.163 Kcal/mol
|Dipole-Dipole Energy
|6.239 Kcal/mol
|6.538 Kcal/mol
|Non-1, 4 VDW Energy
|8.751 Kcal/mol
|1.065 Kcal/mol
|Stretch Energy
|5.041 Kcal/mol
|7.567 Kcal/mol
|Stretch-Bend- Energy
|-0.333 Kcal/mol
|-0.129 Kcal/mol
|Torsion Energy
|-6.825 Kcal/mol
|-8.912 Kcal/mol
|1, 4 VDW Energy
|19.458 Kcal/mol
|9.283 Kcal/mol
Table 1: Physicochemical properties of THC and BDC.
Preparation of protein structures
Availability of several experimentally determined threedimensional structures of COX-2 (1PXX), Phenol sulpho Transferases (1LS6), Matrix metalloproteinases (MMPs) (1GKC), P450 (1OG5) and TNF-alpha (1A8M) co crystallized with various inhibitors provides an excellent basics for using structure-based approaches for the discovery of new inhibitors. All water molecules and if present, ligands were removed from the proteins for docking studies.
Protein-ligand interaction using autodock and GOLD
Autodock (version 3.0): AutoDock 3.0 includes Lamarckian Genetic Algorithm search engine and an empirical free energy function for estimating binding energy, docking energy, inhibitory constant, intermolecular energy, torsional energy and internal energy. Four binding energy terms were included in the score function: electrostatic, van der wall, hydrogen bonding and desolvaion effect. The binding free energy is empirically calculated based on these energy terms and a set of co-efficient factors (Morris et al., 1998).
Using MGLTools 1.5.1, a grid spacing of 0.374 Å with 60x60x60 points for all Proteins was prepared. The grid was centered around the catalytic clef of the enzyme for docking. Docking for 100 number of GA run was carried out using Lamarckian Genetic Algorithm (LGA) and all other parameters set to default. The top ranked model in the lowest energy cluster with maximum cluster size was considered for all further interaction studies.
GOLD (version 2.1.2): GOLD, which is available through the Cambridge Crystallographic Data Center (CCDC) utilizes a genetic algorithm that was originally described by Jones and colleagues and an evolutionary strategy involving three genetic operators; crossover, mutation and migration (Jones et al., 1997; Jones et al., 1995). It was the first algorithm to be evaluated on a large dataset of complexes, possesses an empirical free energy scoring function that estimates the free energy of binding permitting inhibition constants, Ki to be calculated. Although initial applications of GOLD and the GA employed provided poor convergence results for hydrophobic ligands, It has recently been validated using a test set of 305 diverse protein-ligand complexes and 72% of the top-ranked solutions were deemed accurate using the authors' self-imposed stringent success criteria (Nissink et al., 2002).
In assessment using AutoDock 3.0, BDC showed better affinity with all anticancer therapy targets than THC. Interaction of BDC with respect to Matrix Mettaloprotease (MMPs) is represented. A docking energy of -11.46 Kcal/mol with three hydrogen bonds was showed. The hydrogen bond was formed between hydroxyl (H14) of the phenyl ring and carboxyl (O) of hydrophobic amino acid Pro421 by a distance of 2.114 Å (O-H. . . O) and energy of -0.374 Kcal/mol. Another interaction bridging (O5) of the heptane branch and amine (NH2) of positively charged residue Arg424 with a distance of 1.793 Å(N-H. . .O) along a minimum energy of -5.492 Kcal/mol. The hydroxyl (H74) of another phenyl ring and carboxyl (O) of hydrophobic amino acid Pro 430 by a distance of 1.858 Å(O-H. . .O) along with a energy of-1.817Kcal/mol (Figure 3a).
From GOLD also it was observed that BDC showed better affinity with COX-2 and Matrix Mettaloprotease (MMPs) than Phenol sulpho transferases, P450, TNF-alpha anticancer therapy targets though THC showed good affinity to Phenol sulpho transferases, P450 and TNFalpha (Figure 3b).
Analysis of these docked ligands with the proteins brought in focus some important interactions operating at the molecular level. The six-membered phenyl ring plays a vital role in holding the molecule at place (binding) at the active site by three important hydrogen bonds. The present study also attempts a 3D-QSAR study on curcumin derivatives. Applying Lipinski's Rule of five to curcumin derivatives to evaluate druglikeness (absorption,distribu tion,metabolism and excretion), there was no violation of the rule determining drugs pharmacological activity in the body. These studies are expected to provide useful insights into the roles of various substitution patterns on the curcumin derivative and also help to design more potent compounds. The docking studies and 3D-QSAR indicate that substitution of electron–rich compounds may lead to improved biological activity of curcumin derivatives. Thus this study will be useful for the design of novel procarcinogen activating enzyme inhibitors based on docking methods.
CRG and PK thank RSST and Principal SSMRV Degree College for their encouragement and support.


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My article appeared here on 3 June: http://www.mn.catholic.org.au/news-events/aurora/20140603-136/the-time-of-her-life
I have reproduced it below for your viewing pleasure :-)
I hear my young child calling out in the middle of the night. She must have kicked her blankets off again. She must be cold. I am cosy and warm. My blankets envelope me, tempting me to remain where I am, but I know what I must do. I get up and make my way to my daughter's room. I pull the blankets up over her small, curled up body and rub her back to warm her. While I am up, I check on her two older sisters, then finally make my way to my own blankets which have lost a bit of their warmth, as I chase the sleep which has abandoned me.
Why leave the comfort of a warm bed to tend to another? For love.
I hug and kiss my beautiful daughter, then wave goodbye, leaving her in the care of another as I commence the day's paid employment. My heart is torn on a regular basis, but this is a choice we have made as a family, this is my attempt at contributing to our financial security, so my husband and I can both provide for our children's futures.
Why would I forgo time spent with my children? Funnily enough, for love.
In the evenings after my children are asleep, the lure of an unread book, a movie waiting in its dvd cover or an early night to sleep can be incredibly tempting. Sometimes, though, I make comfort wait. Instead I sit at the computer and tap away, creating.
Why work into the night on an unpaid piece of writing? For love.
In this time in my life, I am many things to many people. I am a wife to my incredible husband. I am a mother to three wonderful daughters aged seven, four and two. I am a professional who works 20 hours per week, a hobby-blogger and a debut novelist. I also co-ordinate my daughters' weekly playgroup and my husband and I are in the thick of building a house. I am a daughter, a friend and a parishioner.
This time in my life is full and demanding as I attempt to meet the needs of many with the finite resources of time and energy. However, the infinite resource of love grows more bountiful the more it is used. Love is such a powerful motivation to do so many things. Love for my family. Love for and through my faith. Love for my interests.
Fitting everything in can sometimes seem like trying to do a jigsaw puzzle with one too many pieces. Sometimes a piece of the jigsaw puzzle needs to be put to one side for a while to manage things. An after-school activity might need to be dropped, the blogging might slow down, or we might not socialise for a while. Although love is an infinite resource, it is not a superpower which makes everything possible all the time. Sometimes compromises must be made. Sometimes help must be asked of others. In making decisions about compromise, we prioritise. And in this, I am guided by love.
"Having it all" is a fantasy we are constantly being sold. "Wanting it all" is an aspiration I admit to having. I can wear myself out trying to do so much and fit it "all" in, trying to be the best of everything, when everything encompasses so much. And then I inevitably stop. I slow down. I reflect. I realise, again, that the "all" we are told to have and for which I strive is a subjective thing. My "all" is not what I am sold in magazines. My "all" is the sum of my loves. So I have no reservations in wanting my "all", in working for it, in living it. For my "all", I strive every day.
Although it can be draining, testing and demanding, it is absolutely worth it. In this time in my life, I am having the time of my life.

subset: commoncrawl


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Hey folks,
We are done with the fair, and the Tako cart is now re-assembled to serve again. We are starting service Tuesday through Thursday for a private client. Mondays we are thinking about VCU campus and Fridays we are trying to get downtown by the canal.
We have events stacked up this month, so find us on the weekends at your favorite Richond farmers markets!


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December 1, 1999
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Massage therapy is about to boom – will your salon be part of it, or will it be a bust as some salons have found? The only way to know yourself is to look before you leap
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Indoor tanning has brought year-round color to people in even the coldest of regions. It can also bring you year-round profits in your nail salon, with less trouble and expense than you might think.
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Offering foot reflexology in your salon is a perfect complement to pedicure services.
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JoAnn Har, a nail technician in Hod Hasharon, Israel, gives her clients a little something extra, and it doesn't cost her a cent.
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Tech puts marbles in the pedicure bowl to make it fun and efficient.
April 1, 1995
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Looking for a great add-on service? Here's an idea of what you need to learn, what you need to stock, and how to keep informed on this hot service.
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Because your clients differ your services should, too. Some clients need to get in and out of the salon quickly; others want the total salon indulgence. Make everybody happy by offering several types of manicures.
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By supplementing the natural manicure with nail and cuticle care, massage, aromatic oils and lotions, and good old-fashioned client service, salons are attracting a loyal clientele.
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Paraffin service profits please the nail technician as much as the service pleases the client.
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Refers to the naturally occuring fingernail (as opposed to nail enhancements).
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Solon Mayor Steve Stange administers the oath of office to Lauren Whitehead at the beginning of a June 7 Solon City Council meeting. Whitehead was the winner of a May 30 special election to fill the unexpired term for former council member Mark Krall. The term runs through December. (photo by Doug Lindner)
PEORIA, Ill.– May 19 was a special day for Solon's Joseph Meder. One of the most esteemed honors that can be bestowed on a taxidermist was awarded to Joe during the award ceremonies of the World Taxidermy Championships® recently held in Peoria, Ill. Since the award's inception in 2007, the World Taxidermy Championships® Lifetime Achievement Award has been awarded every two years. Meder is the fifth person to receive this special honor.
It kind of surprised me to find out that when Iowa won the Big Ten baseball championship on Sunday May 28, it was the first time the Hawkeyes were Big Ten champs.
The Hawks went 4-1 in the tournament beating Maryland and Nebraska, losing to Minnesota and then beating the Gophers in a second game before finally knocking out Northwestern in the championship, 13-4.
The Hawks automatically qualified to the NCAA regionals for the second time in three years.
James E. "Harry" Manary, 89, died peacefully Friday, June 9, at Mercy Hospice surrounded by his family.
Funeral service was held Tuesday, June 13, at Lensing Funeral & Cremation Service, Iowa City, with Rev. Randy Harker officiating. Burial was at Oakland Cemetery. A time of fellowship was held at The Kirkwood Room (next to the funeral home). In lieu of flowers, memorials may be directed to Mercy Foundation for the Mercy Hospice.
James was born Feb. 19, 1928, the son of Chester and Nellie (Woods) Manary. James married Carol Grecian on Jan. 5, 1949, in Wapello.
I seem to watch more television these days than I once did. I suppose it's because I'm not as busy– physically, at least, though my mind continues to flit around like orioles in the orchard and has me believing I'm busy even if I'm not. I used to hear television more than see it. I'd catch the news while I was cooking supper but it was mostly audio– the video consisted of mere glimpses, and continuity was spotty since the remote was always in someone else's hands. Today, I get control of that little black box and am allowed to sit and watch every minute of a program.
North Liberty Leader
TIFFIN– The season ended in a shocking fashion Tuesday, May 30, for the Clear Creek Amana (CCA) varsity girls soccer team, The Tigers from Grinnell-Newburg won the Class 2A regional semifinal match with a 2-0 shutout.
The Tigers struck first, 10 minutes into the match, and scored their second goal with 7:53 left in the first half. The Clippers' best chance for a goal came in the second half with a penalty kick after Grinnell's keeper tackled Hannah Bormann in the box. Unfortunately her shot was deflected.
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DES MOINES– Iowa City West High's Trojans went from the bottom of the 2017 Class 3A State Soccer Tournament brackets (eighth seed) to the top, claiming their ninth state championship Saturday, June 3, at the Cownie Soccer Complex in Des Moines.
The Trojans, led by veteran coach Brad Stiles, entered the tournament with a 13-7 record and were pitted against No. 1 seed Cedar Rapids Prairie in the quarterfinals on Thursday, June 1.
North Liberty Leader
IOWA CITY– Iowa City West High's Women of Troy earned a trip to Des Moines and the 2017 Class 3A State Soccer Tournament, which kicks off Thursday, June 8, and runs through Saturday, June 10, at the Cownie Soccer Complex in southeast Des Moines.
North Liberty Leader
OXFORD– Clear Creek Amana's (CCA) varsity softball team moved to a 2-3 mark following a pair of doubleheaders against Marion and West Delaware. The season opened on May 24 with a double-loss to Dyersville Beckman in Dyersville.
North Liberty Leader
WILLIAMSBURG– Clear Creek Amana's varsity baseball team made some history for the program Monday, June 5, with a doubleheader sweep of the Williamsburg Raiders in Williamsburg. The Clippers took the opener 9-1 and won the nightcap, 4-2.
"That's our first sweep of Williamsburg since I've been here," Coach Brent Henry said. Henry took over the program in 2013.


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Latest from Linda NewslettersSign up for my monthly email newsletter with updates on what I am working on in Washington and local events in our community. Click here to receive Latest from Linda updates.
Welcome to my website!My online office is here to serve you – just as if you were to come meet with me or my staff.
Linda Sánchez Elected Vice Chair of the House Democratic CaucusIn a 98-96 vote, Rep. Linda Sanchez (D-Whittier) was elected the next vice chairwoman of the House Democratic Caucus, making her the first Latina to ever serve in House leadership.
Vice Chair Linda Sánchez Delivers Weekly Democratic AddressRepresentative Linda T. Sánchez (CA-38), Vice Chair of the House Democratic Caucus, delivered the Weekly Democratic Address.
Upcoming Community EventsClick here to see upcoming public events being held across California's 38th Congressional District. These events are a key part of my outreach and constituent service. Constituents will have the opportunity to discuss federal issues and upcoming legislation. All events are free and open to the public.
June 8, 2017 Press Release
Rep. Sánchez says: "Suggestions of the president's ignorance are simply disingenuous. He is the President of the United States, not an apprentice."
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Rep. Sánchez says "a little help can make a world of difference for a hard working family."
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Rep. Sánchez says CBO score shows, "Hardworking Americans would be the biggest losers under Trumpcare."
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Rep. Sánchez says Trump budget "would lead to the death of the middle class by a thousand cuts."
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PACE promotes the full participation of people with
disabilities in the rights and responsibilities of society.
PACE is an organization run by and for people who have disabilities. Our board of directors must be made up of 51% persons with disabilities, to insure our services are designed by people who have disability experience and understand what our services need to be to meet similar needs. PACE is one of over 600 Centers for Independent Living in the country, 22 in Illinois. We serve 5 Illinois counties; Douglas, Edgar, Piatt, Champaign and Vermilion. Our services support the efforts of people who have disabilities to achieve or maintain their independence.
Saturday, April 15th
Meadowbrook Park – Urbana
This year, PACE has re-imagined our annual Wheelathon, and turned it into the Independence 5K, a family-friendly 5K for runners, wheelers, and walkers. The Independence 5K will raise money to ensure that PACE can continue helping people grow and maintain their independence.
You'll also be able to visit THE DISABILITY EXPERIENCE PATHWAY," and learn some American Sign Language, experience different types of vision loss, and learn facts about disability.
Thank You Community Foundation
Thank you to the Community Foundation of East Central Illinois for the $7,000 grant which will allow us to begin a program to demonstrate pieces of hi-tech equipment for the blind and visually impaired. Check back for pictures of the equipment, and details about demonstrations!!
Changes afoot at PACE
When you drop by our office you will be noticing some changes…
The history of the disability movement is displayed at PACE: We have pictures spanning the last century of disability history, and want you to come by and connect with the Independent Living movement.
We have a brand new room for the amplified phones, and this room will soon be the home of hi-tech equipment geared at the blind and visually impaired, as well as those with reading disabilities.
Soon, we will also have a dedicated room for Deaf consumers to make videophone calls in private.


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The Best Restaurants in Las Vegas
There are thousands of Las Vegas restaurants, and GAYOT wants to share with you the very best restaurants on and off the Strip. Whether you are looking for our highest-rated Las Vegas area restaurants when it comes to food, or the most romantic, or the best view, you can follow these top 10 Las Vegas restaurant lists and recommendations. Here you can discover the best restaurants in Vegas in a variety of categories.
Find out which restaurants and chefs top the list of GAYOT's 2016 Annual Restaurant Awards.


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600,000 Jobs Depend on New Transpo Bill, Says US Senator
Of the potential job losses, 500,000 are in the construction sector and 100,000 in the transit sector, explains Boxer. Also, Boxer estimates that 43,000 jobs are in danger in her home state of California alone.
In the midst of budget debates and reluctance by some members of Congress to increase revenues, Senator Boxer cites the fact that the US is spending $12 billion per month in Iraq and Afghanistan while the expected shortfall in transportation funding equals $12 billion over the next two years (if the plan she is proposing as chair of the Environment and Public Works Committee is approved).


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Your search for "cox6a2" returned 10 TaqMan® SNP Genotyping Assays
cytochrome c oxidase subunit 6A2
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008]
(Mouse) P43023, (Human) Q02221, (Human) O00761, (Human) Q6GTW6
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NBC Parenthood Max Walks For Autism Speaks But Doesn't Know He Has Asperger's Syndrome
To Tell or Not to Tell Children About Their Disabilities
All kids are different, but when a child has a disability should they be told? Last night on Parenthood, Max is enthused about getting the entire family —Team Braverman — together to participate in an Autism Speaks walk. Though the boy is extremely passionate about helping kids with autism, he has yet to realize that he is on the spectrum. Wondering whether they should tell Max that he has Asperger's syndrome, Adam and Kristina consult their son's doctor. He doesn't give them a direct answer, instead he says that the 8 year old will clue them in when it's time. Do you agree that children will figure it out themselves or give their parents a cue for delivering such news, or should parents be upfront at the time of diagnosis?


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About the Book
Features & Details
- Category Arts & Photography
Standard Portrait, 7.75×9.75 in, 20×25 cm
86 Pages
- Publish Date Sep 01, 2010
- Tags wedding, photography
See More
About the Creator
Brady Art
Santa Monica, California
"YOUR JOURNEY / YOUR COFFEE TABLE BOOK" Providing complete book design from concept through completion including design consultation, production and image retouching. Since 1995 we have been creating award winning projects for small companies, non-profits, artists and photographers.
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Posted by: SoloTouchArchive Author: Maxy Age: 21 (at the time) Posted on: 17 Apr 2013 3 comments
0 likes 585 views Category: Masturbation Male Solo Tags:This started in my second year of uni. I was staying in halls and I had a girl in the rooms either side of me. The rooms were laid out so my bed was directly on the opposite side of the wall to the room next to it, only separated by a wall. The girl in that room every now and then brought guys back in the middle of the... » Read more
Posted by: SoloTouchArchive Author: Amber Age: 37 Posted on: 17 Apr 2013 13 comments
0 likes 1716 views Category: Masturbation Female-Male Tags: caught, mother sonSomething that I never ever intended and now am confused as to what to do....
I have been married for 17 years now. Yes, maybe I married too soon but I was DEEPLY in love. I still love him now but it's not the same. I don't want to sound mean but the sex life is definitely lacking excitement and even enjoyment for the m... » Read more
Posted by: SoloTouchArchive Author: Mark Age: 19 (17 then) Posted on: 17 Apr 2013 3 comments
1 likes 3243 views Category: Masturbation Male-Female Tags:My sister and I are very close. We spend a lot of time together - we hang out with the same friend group as well. She is around two years younger than me - although it's always seemed as though we were the same age - such was our bond. However, in our teen years, if there was one unspoken rule, it was that we don't men... » Read more
Posted by: SoloTouchArchive Author: Anonymous Age: 60+ Posted on: 17 Apr 2013 2 comments
2 likes 1120 views Category: Masturbation Male-Female Tags:This is a fictional story of a young man's needs being met.
Someone shook me awake. It was Mom. Leaning over me she said, "Sorry to wake you, honey, but your grandfather fell and I got to go over there." Brushing sleep from my eyes I asked, "Is he hurt?" "I don't know. Harriet his friend phoned." "W... » Read more
Posted by: SoloTouchArchive Author: George Age: 60 Posted on: 16 Apr 2013 1 comments
0 likes 538 views Category: Masturbation Male Solo Tags:I've met a new gal only briefly recently, but we're getting much closer via email. She knows I'm a horny fellow, as I've told her I enjoy everything about sex & masturbating...but no real details until now! This is an email note I sent her this morning for the first time explaining my nocturnal solo exploits! BTW - I'... » Read more
Posted by: SoloTouchArchive Author: Master Baiter Age: 28 Posted on: 16 Apr 2013 2 comments
0 likes 1290 views Category: Masturbation Male-Male Tags: Preacher's SonI was now a new Phi Mu. The preacher's son would soon be going to his first jacking club meet up. First a XXX theater. This is part of a trilogy. Please read the first two submissions for context and continuity.
I got the news via cell phone. I had been accepted into the music fraternity. The call came from my sponsor. ... » Read more
Posted by: SoloTouchArchive Author: Magic Man Age: 22 Posted on: 16 Apr 2013 3 comments
0 likes 1388 views Category: Masturbation Male-Female Tags:I've been attracted to my sister since my teen years. Seeing her in her underwear was like heaven
My name is Mark and I'm a young male who has suffered through hormones like any guy. But is there anything wrong with me for being attracted to my older sister? Growing up similar in age, we "fought" for use of the shower a... » Read more
Posted by: SoloTouchArchive Author: Beth Age: 19 Posted on: 16 Apr 2013 6 comments
0 likes 2159 views Category: Masturbation Female-Female Tags: mother daughter,At least once a week dad has to work late at night. For the past year I have enjoyed the touch of my mom as we watch TV with dad at work. I wear my robe and lie on the couch with my head in mom's lap. Mom then at some point opens my robe exposing both of my tits. I know what is coming and I work myself up to a heighten... » Read more
Posted by: SoloTouchArchive Author: Tony Age: 18 Posted on: 16 Apr 2013 1 comments
0 likes 618 views Category: Masturbation Male-Male Tags:This is about a dream I had during sleep last night, and although it may be considered a fantasy, it felt very real while I was having it and I would like to share it here for those who I believe will appreciate the story.
I do apologize if it's too long, I think I may have gotten carried away… but hey, ... » Read more
Posted by: SoloTouchArchive Author: NakedGirl Age: 19 Posted on: 15 Apr 2013 2 comments
2 likes 1631 views Category: Masturbation Female-Female Tags:Sometime last summer I finally masturbated outside, but it wasn't exactly the way I had expected it to happen.
It was on a warm Saturday evening and I was out with a few friends for the night. One of them was my best friend, she was with her boyfriend, and the third was a guy I kind of knew that they had been trying to ... » Read more
Posted by: SoloTouchArchive Author: Master Baiter Age: 28 Posted on: 14 Apr 2013 2 comments
1 likes 1883 views Category: Masturbation Male-Male Tags:He had come to college well prepared in all subjects but one, the joy of self pleasure. I took care of that.
We had been dormitory room mates for about a month. Although we had developed a friendly relationship, we knew little about each other personally. We occasionally studied together since we took some of the same c... » Read more
Posted by: SoloTouchArchive Author: Gary Age: 27 Posted on: 14 Apr 2013 0 comments
0 likes 859 views Category: Masturbation Male-Female Tags:My girlfriend and I are usually the ones who are leaving our local gym last, at 10pm. Just after exercising we take a shower together - it´s divided into a men and women part, but since we are the only ones in the place we shower naked together. They have never told us it was wrong, so we do it all the time. About t... » Read more
Posted by: SoloTouchArchive Author: Master Baiter Age: 28 Posted on: 14 Apr 2013 5 comments
1 likes 1361 views Category: Masturbation Male-Male Tags: PreacherWinter break is over and pledge week is coming up. This is a continuation of Preacher's son 1. Please read it first for continuity and context.
It is a mid western liberal arts college with a student population of about 2000. It is known for it's fine arts programs. There was a jock dorm, a teacher dorm, an engineer dor... » Read more
Posted by: SoloTouchArchive Author: Morning Girl Age: 40s Posted on: 14 Apr 2013 5 comments
1 likes 1554 views Category: Masturbation Female-Male Tags:A friend and I both have partners with low libido, so we masturbate to make up for the lack of sex. We have had a few discrete sexual encounters which I can't discuss here, but I think it is okay to say the sex was memorable. We do not live within driving distance, so we share masturbation stories and fantasies abou... » Read more
Posted by: SoloTouchArchive Author: mark redford Age: 68 Posted on: 13 Apr 2013 1 comments
1 likes 1206 views Category: Masturbation Male-Female Tags:This happened eight years ago.
A friend of mine asked me to help lay a concrete slab at his house. It was a hundred mile drive back to my house and he was going to pay me. We did a great job on the slab and his wife fixed dinner for all of us. We ate and drank. My friend said he wanted to go finish up stuff on his c... » Read more
Posted by: SoloTouchArchive Author: mark redford Age: 68 Posted on: 13 Apr 2013 2 comments
1 likes 725 views Category: Masturbation Male Solo Tags:From my freshman year in high school and even in the Army, nearly everywhere I went I managed to cum in women's nylon panties. The opportunity's were rather endless as in going to parties with my parents, over to relatives homes, my mothers panties, my sisters panties, my aunts panties and especially exciting was usin... » Read more
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Apply for disaster assistance.
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August 16, 2017 | 12:00 pm PDT - 1:00 pm PDT
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She would get home about midnight and shoo me away.Ugg Alvina Collection Details: Upper: Mini height version of the Bailey Bow Fixed, decorative corduroy bow along back shaft Insole: Includes UGGpure™, luxurious natural wool woven into a durable backing that delivers the comfort of UGG with a plush sensory experience.Ugg Boot For Sale He needed some parts that HP made, so he picked up the phone and called the CEO. UGGpureTM sockliner. "Steve and I were both into personal growth, so I wanted to go with him," Kottke recounted, "but I couldn't afford it. "Within three blocks, we found seventeen examples," said Jobs. As she went on talking helistened in a drowsy, interested way. ugg leather boots He had never been that close to a gun, and he was terrified.Ugg Boots Mens "Within three blocks, we found seventeen examples," said Jobs. I'm from California but now live in Washington, DC and wasn't used to needing a heavy weight jacket for winter time, but this thing is amazing. He instead worked on finding ways that a donated Apple II and a VisiCalc program could make it easier for the foundation to do a survey it was planning on blindness in Nepal."Mary began to recover her breath and feel safer becausethe idea of keeping the secret seemed to please him. They named the fonts after the stops on Philadelphia's Main Line commuter train: Overbrook, Merion, Ardmore, and Rosemont.Lo Pro Ugg BootsMens Ugg Boots Uk "The reality distortion field was a confounding mélange of a charismatic rhetorical style, indomitable will, and eagerness to bend any fact to fit the purpose at hand," he said.
When some of his friends, such as Larry Tesler, decided to join the Macintosh group, Horn considered going there as well. Ugg Alvina "There really wasn't much going on in industrial design, particularly in Silicon Valley, and Steve was very eager to change that," said Lin.Black Ugg Slippers Women"Mary began to recover her breath and feel safer becausethe idea of keeping the secret seemed to please him. It was Sunday and the library was closed, but they knew how to get in through a door that was rarely locked. I also tried contacting the main office in Canada but have yet to receive a positive response from there either. very happy. [Ugg Alvina] That spiritual quest had caused him to eschew material possessions, but he was nonetheless impressed by Jobs's tape deck.
This adorable update to the original flaunts a girlish, flirty bow in our seasonal Candy Striped Silk Twill.Lo Pro Ugg Boots" Sometimes he came in on Sunday morning, so Kare made it a point to be there working." The third and equally important principle, awkwardly named, was impute." Jobs even tried to reengage Wozniak. His thought was - how hard it is to tell how dull these stolid English actually are! He said cordially, "Oh, but you won't be that! You do your part well. [Ugg Alvina] He was leaning on an Apple II and looking directly into the camera with the mesmerizing stare he had picked up from Robert Friedland.
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English Premier League's Fulham to erect statue of Michael Jackson
LONDON (AP) Fulham's "Bad." You know it.
At least they soon will be, in the positive sense, when a statue of Michael Jackson is erected outside the football club's stadium in southwest London to commemorate the late pop star's friendship with Fulham chairman Mohamed Al Fayed.
The figure is scheduled to be unveiled at Craven Cottage on April 3, the same day the club faces Blackpool in a Premier League match.
"Michael Jackson was truly a legend, a term used too often in this modern world saturated in the hyperbole surrounding celebrity," Al Fayed said Wednesday. "He was my friend, a man with whom I shared many happy memories and who died a tragic and untimely death."
Jackson, whose hits include Bad, Billie Jean and Thriller, died in Los Angeles on June 25, 2009.
Al Fayed, a native of Egypt, is the father of Dodi Al Fayed, who died with Princess Diana in a car crash in Paris in 1997. In recent years, Al Fayed has devoted much time and money to pursuing his claims that the couple were the victim of an establishment conspiracy.
Fulham, currently in 11th place in the Premier League, has never won the English league title but reached the final of the Europa League last season before losing to Atletico Madrid.
The statue had been slated to be erected outside Harrods department store, but that plan was changed because Al Fayed sold the landmark business in Knightsbridge last year. Instead, it will be located along the banks of the River Thames next to Fulham's small stadium.
Jackson visited Craven Cottage in the past, sitting next to Al Fayed and wearing a black and white Fulham scarf.
"He left behind a legacy of music so vast it takes one's breath away; from a precocious talent to an ingenuity and groundbreaking modernity that shall never be repeated," Al Fayed said. "It shall often be imitated, but it will never be replicated, Michael Jackson was, and shall always remain, one of a kind."
Fulham did not specify if goalkeeper Mark Schwarzer would wear only one glove to honor the late singer.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Posted | Updated


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Industry Research : Local Call Centers See Increase in Revenue by 2016
Mar 27, 2013 -- The Philippines will remain a preferred destination for voice-related services required by overseas clients despite the appreciation of the peso and the competition posed by other countries such as India, the Contact Center Association of the Philippines (Ccap) said.
The strong performance of the local call-center sector in 2013 and expectations of its continuous expansion in the next three years prompted Ccap to revise its revenue and job-generation targets by 2016.
Local call enters are looking at increasing revenues to $15 billion and creating around 900,000 jobs by 2016. Previously, Ccap targeted revenues of $14.7 billion and the creation of 860,000 jobs.
In 2012 total revenues of call centers went up by 21 percent year-on-year to $8.6 billion, from $7.1 billion a year ago.
This year Ccap is targeting a year-on-year increase of 15 percent in terms of revenues.
"Philippine call centers will continue to be favored by clients because of the quality of service we provide," said Ccap Executive Director Jojo Uligan in a telephone interview.
Ccap earlier warned that the continuous appreciation of the peso against the dollar could pose a threat to the expansion of the local call-center industry. The strengthening of the peso can cut into the margins of local call centers since they bill their clients in dollars.
Uligan, however, said local call centers have remained resilient despite the appreciation of the peso to below P41 against the dollar.
"Definitely, the appreciation of the peso will result in lower margins for us but local call centers are still surviving," he added.
Government data showed that the monthly average peso-dollar exchange rate slightly went down to 40.6723 in February, from 40.7295 in January. In February the peso remained strong compared to the US dollar.
Posted by Veronica Silva Cusi, news correspondent
Source: http://businessmirror.com.ph
Related Editorial
More Editorial From Contact Center Association Of The Philippines
- Investment in Call Center Industry Slows in Q1
- Change in Tax Worries BPO Clients
- Impact Sourcing Offers Huge Potential
- Fearing Trump, Philippine Call Centers Look to Regional Growth
- US to Remain Philippines Call Center Industry's Top Partner
- Globe Business Advances Contact Center Industry Expansion in Philippines
Published: Tuesday, March 19, 2013


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Tort Liability and Defenses
1. Mary is cutting weeds at her home. She is unable to trim some weeds she finds, because they grew between the rocks, so she removes the protective guard on the weed trimmer and trims the weeds. There are no warnings on the weed trimmer advising against removing the guard. She hits a rock, which is thrown to the side, hitting


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Bollywood's beauty queen Priyanka Chopra made everyone's jaws drop while she walked the ramp at the Lakme Fashion Week (LFW) Winter/Festive 2013 for the American fashion designer Michelle Bohbot. This model turned actress looked stunning in a black off shoulder top and black pants. She sashayed down the runway with a perfect attitude.
Priyanka enjoyed walking for the Lakme Fashion Week. She also Bollywood actresses Bipasha Basu and Lara Dutta."Apart from me I think Bipasha and Lara can do jalwa (magic) on the ramp. It is great to walk the ramp but scary as well," she expressed at the sidelines of LFW.
The 31-year-old also spoke about the outfit that she flaunted on the runway. She said, "Black is my favourite colour. I think it looks good and stylish anytime and on everyone. I think it gives confidence."
Reliance Trends partnered with Lakme Fashion Week this season to launch Michelle's exclusive 'Bisou Bisou' India collection today. The designer was very happy to have Priyanka on her show."It is a matter of great pride for Bisou Bisou to have entered into an association with Reliance Trends. I am happy that Priyanka was here. She looked the best," designer Michelle said.
Have a look at the slide show for images and details of Piggy Chops on the ramp. (Inputs from IANS)
The Oomph Factor
This gorgeous actress walks with the right amount of confidence. At the Lakme Fashion Week, the black outfit worked like magic for PC.
Flying Kiss
Priyanka Chopra also gave a flying kiss to the audience and later she told us that it is the designer's signature statement. "This is a standard for all of Michelle's shows. She had told me that it is their signature statement to blow a flying kiss to the audience," Priyanka said.
Miss World
Priyanka Chopra was Miss World in the year 2000 and the actress still has the same charm she had back then.
Looks Forward To Zanjeer
Piggy Chops is looking forward to her next film titled Zanjeer. "I am very excited to be here. Bisou Bisou is my favourite brand. I am so excited that Bisou Bisou has associated with my film, Zanjeer. My character is very fashionable" she said.
Click here for images of Zanjeer
PC With Her Designer
Priyanka Chopra poses with designer Michelle Bohbot. The designer definitely looks impressed after PC's walk.


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|By Mageddon725
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Book 1
Chapter 17
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Chapter 17: Downtime
Zuko welcomed Team Avatar and the Kyoshi Warriors into the main hall of the Fire Nation Royal Palace. "Make yourselves at home. Your quarters are being prepared as we speak, and we have a couple of hours before the real work begins."
"So..." Sokka began, "What is there to do around here?"
Zuko smiled. "Well, you could explore the city, the palace, or for any aspiring sword masters, Piandao might be willing to give you a free lesson."
Sokka's eyes widened as Piandao stepped into view. "Hello, Sokka."
The young man bowed. "Master Piandao."
Zuko scanned the rest of the group. "You have free rein of the Palace and the city; enjoy yourselves while I attend to a few matters."
Piandao sat down cross-legged as each individual went their own way. Sokka approached with an eagerness about his step. "Master, I wish to ask you for further instruction. My training is not yet complete."
The swordmaster smiled. "Very well." He stood slowly, but as the old master reached full height, he whipped his sword out and spun around. "Let us begin."
Yun, Ty Lee, and the other Kyoshi Warriors gathered around to watch. Sokka readied himself but was still driven back by the onslaught of blows. Piandao moved forward, thrusting horizontally, while Sokka attempted to execute attacks of his own. As the master drove his student back towards one of the decorative trees, Sokka came up with a plan.
Piandao lunged forward as Sokka turned; the young warrior barely made it high enough as the blade penetrated the tree. He had run up the plant and back flipped off, landing behind his opponent. Piandao dodged Sokka's forward stroke while trying to dislodge his blade. He was able to rip it out, taking a large chunk from the middle, just as Sokka swung above his head. He ducked and crescent kicked Sokka's sword to the ground and held it there with his foot.
Sokka, realizing his position, did the sensible thing: he ran.
Aang held Katara as they viewed the city from a balcony connected to both of their rooms. "It's such a beautiful city." Katara whispered, stunned at its magnificence.
"Yeah..." Aang replied, staring at Katara, "You are."
Katara grinned. "What was that?"
Aang rubbed the back of his head, blushing, as he tried to cover. "I—er...I meant..." He stopped speaking as Katara leaned in to kiss him."It's okay; I thought it was sweet."
"Heh, heh..." Aang expelled a breath. I'm such a klutz. Desperate for another topic, he began to speak. "The world has changed so much. It almost seems like they don't need me anymore."
Katara raised an eyebrow. "Why is that?"
Aang released his hold on her. "It's just... with the Fire Nation no longer a threat, with the War over, what is my purpose?"
She looked down at the courtyard and shrugged. "That's for you to figure out. But there's nothing wrong with peace; there's nothing wrong with settling down." She turned and smiled.
He felt the heat rising to his cheeks again. "Maybe not. Thanks, Katara."
There was a knock on Aang's door. "Who's there?"
"Sir, Fire Lord Zuko wishes to see you."
"I'll be right there!" He turned to Katara. "You want to come?"
She put her hands on his shoulders. "Why wouldn't I?" She pulled him into her embrace. "Let's go, Mr. Big-Shot Avatar."
Sokka searched for something, anything that would get him out of his current predicament. He then remembered his boomerang. He still had it on his back! He pulled it out and whipped it toward Piandao, immediately sprinting toward him after throwing it. The older man stepped off of his sword in order to dodge the projectile, and Sokka dove, grabbing his sword and righting himself.
Piandao smirked. "That's the way to go! Distract your opponent to regain ground, time, or in some cases, your weapon."
Sokka sent three swift strokes toward his master, but they were only a ploy to enable Sokka to get closer and push Piandao's blade with his own. As his opponent pushed down, instead of going on his back, Sokka slid between Piandao's legs and swiped them out from under him. That couldn't keep the swordmaster down for more than a few seconds, though, and Piandao stood, waiting for Sokka's next move.
"Excellent! Keep me off balance."
Sokka's next few blows alternated between high and low strikes, but no matter what, Piandao could not be moved from his stance.
"Though the art of the sword is fluid, there are times when you must stand your ground!"
Piandao ended the fight by slapping Sokka's sword hand with the flat of his blade, sending the weapon flying. He then sheathed his own sword. "Excellently done, Sokka! You have improved immensely. I am proud to have you as a student."
Sokka bowed. "And I am honored to have you as my master."
Piandao looked over at Yun, and something of an epiphany flashed briefly in his eyes. "I see the blade on your back, but can you use it?"
Yun glanced at Sokka, who gave him thumbs-up. "Well, I don't have any formal training; I mainly use it as a last resort or to augment my bending." He removed it from his sheath and handed it to Piandao.
The blademaster stroked his goatee. "Interesting, it seems that your sword is made entirely of earth."
Yun nodded. "I made it myself using Earthbending. Over time I was able to compress different sections of it to make it harder than most metal."
Piandao smiled. "Excellent craftsmanship from something unconventional, let us see if it works." He drew his blade and waited.
Yun closed his eyes. I hope I know what I've gotten myself into.
Aang and Katara stepped into the throne room, and Zuko came off of his throne. "You wanted to see me, Zuko?"
"Yeah, I thought, well, since your Firebending still needed some work, that you wouldn't mind some extra training."
Aang gave a half-smile. "Yeah... as fun as that sounds, I'm not exactly sure I want to do anymore Hot Squats."
Zuko chuckled. "That's not up to me. I won't be teaching you."
Aang shook his head. "What?!" He and Katara both asked in unison as Zuko stepped out of the room.
"If the Avatar would have me, I would be honored to teach him." Jeong Jeong stood.
"Master Jeong Jeong!" Aang beamed. "You're my teacher?"
The old Firebender nodded. "If you would have me."
"Of course! I would be honored to learn from you." Aang's face fell. "That is... if you'll forgive me for what happened the last time."
"Avatar Aang, you have shown maturity far beyond your years in the way you chose to defeat Ozai. You are no longer the child that came to me; you are no longer reckless. You are forgiven."
Aang grinned. "Then let's get started!"
Yun couldn't have anticipated the sheer amount of strength and skill coming from someone who looked as old as the man in front of him did. But it was there; Piandao struck with precision and power. Yun Zhen was constantly retreating; he had to think of something. Though he could feel Piandao's steps, his motions were so fluid that he found it incredibly difficult to discern anything from them. His Seismic Sense was enough to anticipate only the generality of his attacks.
The master's attack string ended as Piandao gave Yun a hard shove. As he slid backward, the young Earthbender sunk his feet into the ground, and when he brought them back up, they were covered in earth. He used that in conjunction with the earth under him to slide along the ground, attacking and then immediately moving out of range.
"Yes, use your bending in tandem with your sword, and few will be able to touch you!" Piandao flipped his sword behind his back and waited.
As Yun slid toward him for another pass, he dug his hand into the ground and launched sand at his opponent's face, but Piandao was ready. As the sand came toward him, he spun his sword in an arc, dispersing the attack. He then whipped his sword down and tripped Yun as he slid by.
Yun sat up, rubbing his head, as his opponent sheathed his sword. "You too have the makings of a great swordmaster; you both simply need to keep practicing." He glanced at Yun. "Although it is peculiar that a Fire Nation citizen would also be an Earthbender."
Yun's eyes widened, and Sokka's jaw dropped as he pointed to Yun and back at Piandao. Yun stood. "That's not exactly common knowledge. I'd like to keep it that way."
"Of course, I meant no harm; I am simply curious as to how my younger brother managed to get a girl to marry him."
Yun's heart stopped as Ty Lee shot up and cried out. "What?!"
Sokka fainted.
The guards opened the door to Azula's cell. "You can be assured that no one has been here, Fire Lord Zuko."
"Good." He stepped into the pristine white room. "Hello, Azula."
She turned, smiling. "Oh, hello ZuZu, how is his Fire Lordness these days?"
"Stop with the games, Azula. What are you planning?""The weather has been oh so nice; I wish you could have been here yesterday."
Zuko was losing patience. "What are you up to, Azula? Tell me!"
She skipped from one end of her cell to the other. "My day has been fine; thanks for asking."
Fire jumped to Zuko's hands. "Enough games! I'm about do—!"
"Mother visited the other day."
Zuko's eyes widened, and the flames died as quickly as they'd come. "What?"
"She visited me, oh, about two days ago."
"You're lying. No one has been here."
"Not true." Azula face sported an evil grin. "She came to see me and not you. You're just jealous."
Zuko turned and stormed out of the cell. "You are absolutely certain that no one has been here but me?"
The guard stood at attention. "Yes, Fire Lord."
As he walked down the hall, he couldn't help thinking it. Azula always lies. Azula always lies.
- Yes, I did actually kill a tree in this chapter...
See more
For the collective works of the author, go here.


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Senior Java Developer - Gloucestershire - £45K-£60KBenefits
Senior Java Developer - Gloucestershire - £45K-£60KBenefits A job should be exhilarating - somewhere you can learn cutting edge technologies, where you are encouraged to share ideas and your ambitions are nurtured. People Source are acting as retained managing agent for our client who are a unique cloud SAAS company based in the heart of the Cotswolds. Combining state of the art software with a unique global e-commerce proposition, they are revolutionising the retail industry and have established business with leading brands and retailers around the world. Their philosophy is centred around innovation and progress and this radiates throughout the work culture. You will join inspirational leaders and best in class technologists who are all making an impact on ground-breaking projects in the e-commerce world. Life at our client is fast paced, fresh and exciting - a place where people are more than just a job title. Everybody has a voice. The Job: As a Senior Java Developer you will be working together to create cloud based solutions that will be used by major brands and retailers globally. This is an exciting opportunity for talented and passionate Senior Java Developers to be part of a revolutionary business which will be career defining. We are keen to speak to experienced Senior Java Developers who would like the opportunity to work with a unique organisation and the very latest Java technologies within an agile environment. This job will focus on Java development using Core Java, Spring MVC, Cloud Platforms (AWS) etc. and we are particularly interested in speaking to Senior Java Developers who have some experience in most of the following: Core Java, Spring MVC JUnit and integration testing JDK 6 / JDK 7 / JDK 8 SOAP and REST XML, JSON JPA or Hibernate Test Driven Development Jira Linux Agile (Scrum, Kanban etc.) Test Driven Development Beneficial skills: NoSQL Databases such as MongoDB or DynamoDB Cloud Platforms/Amazon Web Services (AWS EC2) BDD Git JDK 8 IntelliJ JBoss or Tomcat Spring Integration or similar (Mule ESB, Camel, Fuse) The Dev Team: The development team is made up of some really smart people. You will be working alongside developers that really know their stuff; people that you can learn from and with. The team has embraced a modern development culture and you can expect the following: TDD (BDD) and use of Scrum with Kanban as an Agile/Lean development methodology Working on Apple Mac Relaxed dress code Flexible hours Interested? Please apply with your CV to for immediate consideration, and call me on 01179227000 with any queries on this, and alternative best in class Senior Java Developer positions across the UK & Europe. People Source Consulting Ltd is acting as an Employment Agency in relation to this vacancy. People Source specialise in technology recruitment across niche markets including Information Technology, Digital TV, Digital Marketing, Project and Programme Management, SAP, Digital and Consumer Electronics, Air Traffic Management, Management Consultancy, Business Intelligence, Manufacturing, Telecoms, Public Sector, Healthcare, Finance and Oil & Gas. This job was originally posted as www.cwjobs.co.uk/job/66866960


text:
TNA is looking for new staff in the publicity department. Chris Thomas, who had been working for the PR department for many years has left for a job in Hollywood.
Thomas was known as one of the hardest working office staff in the company.
No reason to hate on Chris Thomas. He had the choice of staying in tna or working in Hollywood, and he chose Hollywood in which I think he made a great choice
You're a whore.
Lmao yea I know your a whore, and I'm also not a major tna mark like you
Eh, I'll take the title "TNA mark" over "WWE mark" any day.
whos hating on him? i see no one. bit weird.
TNA has had pretty bad Public Relations.
Good oportunity here ^^
I was hoping Pritchard 🙁
Goodbye Chris, we hardly knew ye.
I gave you a thumbs up just for having a great name & cool pic! And because I'd rather be at Nitro too!


text:
About the Book
Havi Rojer tells the story of her grandfather Charles Rojer's childhood when he was a hidden child in Nazi Occupied Belgium during World War Two. A powerful and moving living history of the holocaust is told through the voice and illustrations of a 13 year old young woman coming of age for her bat-mitzvah project.
Features & Details
- Category History
Standard Landscape, 10×8 in, 25×20 cm
28 Pages
- Publish Date Mar 16, 2014
- Language English
- Tags Holocaust, Living History
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By MARCUS FRANKLIN and LIZ SIDOTI, Associated Press Writers
NEW YORK Republican Sen. John McCain will officially enter the presidential race -- his second run after a bitter loss to George W. Bush in 2000 -- with a formal announcement in early April after a trip to Iraq.
The Arizona senator discussed the timing of the long-expected announcement with reporters at an awards reception Wednesday evening a few hours after taping an appearance on CBS' "Late Show With David Letterman."
McCain told Letterman: "The last time we were on this program, I'm sure you remember everything very clearly that we say, but you asked me if I would come back on this show if I was going to announce. ... I am announcing that I will be a candidate for president of the United States."
McCain said he would make a formal announcement in early April. He later told reporters that he would visit Iraq first and that his campaign would be about "whether I have the vision, experience and knowledge to lead the nation."
Former New York Gov. George Pataki introduced McCain to reporters before the Irish-American 10th Annual Awards reception Wednesday night. Asked about polls showing him trailing former New York Mayor Rudy Giuliani, McCain said: "We keep doing the best we can. We're very happy with the way things are going."
There had been no doubt that McCain would eventually become a full-fledged White House candidate, and he had been expected to make his candidacy official in the spring.
The 2006 midterm campaign had just ended when McCain took the first formal step toward a presidential run in November. He formed an exploratory committee and gave a speech casting himself as a "common-sense conservative" in the vein of Ronald Reagan who could lead the party back to dominance after a dreadful election season by returning to the GOP's core principles.
A political celebrity, McCain is considered a top contender for the nomination.
However, he faces strong challenges from Giuliani, who has widened his lead over McCain in popularity polls in recent weeks, and former Massachusetts Gov. Mitt Romney, who is little-known nationally but is drawing notice for his deft fundraising.
The other two have spent the past two months mostly campaigning while McCain largely has been tied to Capitol Hill in his role as the highest-ranking Republican on the Senate Armed Services Committee, which is focused largely on the unpopular Iraq war.
McCain, a former Navy pilot who was a prisoner of war in Vietnam, has emerged as the Senate's go-to guy on Iraq. He has become President Bush's most outspoken supporter of sending 21,500 additional U.S. troops to Iraq, a position that could endear him to GOP primary voters but anger much of the rest of the electorate.
A four-term senator, McCain unsuccessfully ran for president in 2000 against Bush and has been laying the groundwork for a second run for more than a year.
Since losing that race, McCain has alternately challenged and embraced the president, building an independent reputation as one who isn't afraid to speak his mind. At the same time, he's sought to mend fences with conservatives he alienated in his first presidential run.
Should he win this nomination and then the presidency, McCain, 70, would be the oldest president ever sworn into office for a first term. Only Reagan, who was 73 at the start of his second term, was older.
Asked by Letterman if he would consider being a vice presidential candidate, McCain repeated an answer he gave in 2004 when he was mentioned as a possible running mate: "You know, I spent all those years in a North Vietnamese prison camp, kept in the dark, fed scraps -- why the heck would I want to do that all over again?"
Politicians often turn to late-night talk shows, watched by millions and popular with younger viewers, to try to display a sense of humor and otherwise broaden their appeal.
In 2003 actor Arnold Schwarzenegger used NBC's "Tonight Show With Jay Leno" as the forum to announce he would run for governor in California's recall election.
John Edwards, then a little-known Democratic senator from North Carolina, previewed his 2004 presidential bid on Comedy Central's "The Daily Show With Jon Stewart" the night before his official announcement. Texas businessman Ross Perot launched his 1992 campaign for president on CNN's "Larry King Live."
Liz Sidoti reported from Washington.
Copyright 2007 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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SEO my Website - 09/10/2016 03:51 EDT
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Welcome to The Rainbow Project Media Centre. You will find our most up to date versions of our current publications as well as contact details for the purposes of media or publicity.
Media Enquiries
All media enquiries should be directed to:
- John O'Doherty
(028) 9031 9030
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(028) 9031 9030
If contacting The Rainbow Project outside normal working hours please email firstname.lastname@example.com and someone will get back to you as soon as possible.
You must request permission to use The Rainbow Project logo or any logo associated with The Rainbow Project. Should you require the use of The Rainbow Project's logo for media, publication, or website, please contact the Director, John O'Doherty who can provide you with a range of colours and formats in different sizes and resolutions.
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Monday – Friday: 10 am – 5.30 pm
Saturday: Closed
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Maritime Noon
Maritime Noon | 1-800-565-1940 | Weekdays 12 p.m. to 1 p.m.
Join the conversation with Norma Lee MacLeod live at 1-800-565-1940 or by calling the talkback line at 1-800-565-5463.
Maritime Noon Clips
Wednesday July 26, 2017
Audio Dog Rescue, Song Feedback, Maritime Future
The Canadian Coast Guard rescues a dog. You share your favourite songs about work. Author Donald Savoie talks about his book "Looking For Bootstraps: Economic Development in the Maritimes".
Tuesday July 25, 2017
Audio Lyme Disease Warning, Monopoly Feedback, Working Songs
A Nova Scotia mother says she didn't realise her son was bitten by a tick. Your Monopoly stories. Plus: songs about work.
Monday July 24, 2017
Audio Ocean Safety, Drone Feedback, Monopoly
The Canadian Red Cross speaks about water safety. Your thoughts on drones. On the phone-in: Monopoly memories.
Friday July 21, 2017
Audio Dangerous Drones, Poison Feedback, Superheroes
A drone delays a Lifeflight helicopter at a crash site in Nova Scotia. Your thoughts on poison control. On the phone-in: who's your favourite superhero?
Thursday July 20, 2017
Audio Another right whale death, Phone-in on dealing with accidental poisoning, 87-year-old woman goes skydiving
Another right whale found dead, Feedback on banning junk food ads to children, Phone-in on dealing with accidental poisonings, 87-year-old woman celebrates her birthday by going skydiving
Wednesday July 19, 2017
Audio Covered bridge damage, Rainbow crosswalk feedback, Plumber Fred Walsh takes calls
Overweight government trucks damage NB covered bridge, Feedback on Woodstock rainbow crosswalk vandalism, Plumber Fred Walsh takes calls
Tuesday July 18, 2017
Audio Rainbow crosswalk repainted after vandalism, NS firefighters head to BC, Phone-in on junk food advertising to children
Woodstock NB repaints rainbow crosswalk after it was covered with white paint, NS firefigher talks about heading to BC, Phone-in on junk food advertising to children, Feedback on hunting with drones
Monday July 17, 2017
Audio Dangerous BBQ brushes, Call to crack down on hunters using drones, Paint expert Jim White takes calls
Man talks about swallowing wire bristle from a barbecue brush, Call for a crackdown on hunters using drones to track wildlife, Paint expert Jim White takes calls
Friday July 14, 2017
Audio New License, Cornwallis Feedback, Marjorie Willison
A 74-year-old N.B. man has to take his driving tests again after not renewing his license. Your thoughts on removing the Edward Cornwallis statue in Halifax. Marjorie Willison answers your gardening questions.
Thursday July 13, 2017
Audio Stolen Vet Drugs, Rates and Debt, Dumping Straws
A lethal drug is stolen from a N.B. SPCA. We talk about rates and debt with Linda Wilke from Credit Counselling Services of Atlantic Canada. Plus: A Halifax restaurant dumps straws.
Wednesday July 12, 2017
Audio Call to pull down Cornwallis statue, Chef Craig Flinn offers BBQ tips, Feedback on finding solitude
Mi'kmaq activist calls for rally to pull down Halifax's Cornwallis statue, Chef Craig Flinn offers BBQ tips, Feedback on enjoying solitude.
Tuesday July 11, 2017
Audio Whale rescuer killed, Phone-in on the value of solitude, Father of the bride gets shocked at wedding
Whale rescuer killed while disentangling right whale from rope, Phone-in with author Michael Harris about the value of solitude, father of the bridge gets struck by lightning at wedding
Monday July 10, 2017
Audio Facebook hoax message, Arborists take tree questions, Feedback on credit unions being told not to use the word 'bank"
Facebook hoax message spreads around the world, Arborists take questions on tree, Feedback on credit unions being told to stop calling themselves banks
Friday July 07, 2017
Audio Cigarettes starting fires, Feedback on electric cars, Phone-in on what to do with the family cottage
Moncton Deputy Fire Chief warns of the dangers of not extinguishing cigarettes, Feedback on electric cars, Phone-in on how to hand on the family cottage
Thursday July 06, 2017
Audio Credit Unions told to stop calling themselves banks, Feedback on Proud Boys, Phone-in on self-driving cars
Credit Unions told to stop calling themselves banks, Feedback on Proud Boys, Phone-in on a future with self-driving cars
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Join us for free concerts, live radio shows and family activities, July 28 - 31
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Halifax Pride Festival runs July 20-30, Pride Parade July 22.
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- Republican plan for quick Obamacare repeal fails in Senate
- 1 dead, 7 hurt after Ohio fair spinning ride Fire Ball breaks apart
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- Canada promotes recruitment of transgender troops as Donald Trump imposes military ban
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- Mom and baby spared traumatic birth after heart surgery performed inside the womb
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text:
Larry Bird and Magic Johnson were once credited with making March Madness a thing. But for Bird, the road to the NBA was long and rocky.
March Madness
There's Nothing Random About this Final Four
Wherever you look, discussions about how "random" this Final Four are taking place. But if you've been paying attention, that's not the case at all.
Guards That Dominated March: Ball, Fox and Williams-Goss
Continuing our focus on superior guard play in March, we turn to Lonzo Ball, De'Aaron Fox, Nigel Williams-Goss, and plenty more.
Guards That Dominated March: Thornwell, Dorsey and Mason
The key element to this year's NCAA tourney has been superior guard play. In the first of our two-part look, we focus on Thornwell, Dorsey, and Mason III.
It's Hard to Bet Against the Tar Heels Now
With the Final Four picture officially set, it's tough to look beyond the Tar Heels. Because sometimes, the obvious choice is the correct one.
It's Too Late to Start Taking the Gamecocks Seriously
Jump on the Gamecocks bandwagon now because you won't get away with pretending you've been in their corner all along. They're here now; how foolish were we?
Down Go the Jayhawks; Now What?
Saturday night's NCAA action came to a close with the Kansas Jayhawks slipping up at the worst possible time. Where does that leave us? And, what's next?
This is the Gonzaga We've Been Waiting For
The year is 2017, and the Gonzaga Bulldogs are suddenly two wins away from a National Championship. Should we be surprised? No. We've been waiting for this.
The Badgers Just Wouldn't Go Away, But…
Day 6 of the NCAA Tournament gave us our first buzzer-beater, but at the expense of the Badgers. Plus, hey, John Calipari knows what he's doing.
Why UCLA/Kentucky is a Matchup for the Ages
Can UNC become the third 1-seed to reach the Elite Eight? Meanwhile Florida/Wisconsin are evenly matched, and UCLA/Kentucky promises to be a treat.
Hero Ball Bites West Virginia, Arizona
Day 5 of the NCAA Tournament wasn't kind to both West Virginia and Arizona. But, they didn't do themselves any favors with the ball in their hands late.
Why This Isn't the Same Old Gonzaga
There's plenty of NCAA Sweet 16 action to look forward to tonight, but most of all, we should no longer be surprised by Gonzaga. Not this season, anyway.
Why This Isn't the Same Old Gonzaga
There's plenty of NCAA Sweet 16 action to look forward to tonight, but most of all, we should no longer be surprised by Gonzaga. Not this season, anyway.
How Much Did the NCAA Get Wrong Over the Weekend?
With Day 4 of the NCAA Tournament in the rear-view, we look back at all 'we' got wrong over the weekend. I thought Duke was back—what happened there?
Why Do We Take Calipari's Dominance for Granted?
John Calipari may not have led his Kentucky Wildcats to multiple National Championships, but we're beginning to take his dominance for granted.
Wisconsin Provides That Pick-me-up
After two days of the NCAA Tournament, I was crying out for something big. Then Wisconsin arrived and took down the defending champions. That wasn't all.
March Madness Needs a Pick-me-up in Round Two
It's March! or so we keep hearing. But there has been little madness throughout the first two days of the tournament. Is that going to change?