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MATLAB Newsgroup
Hello all,
I need to generate g-codes for some path profiles that I've generated in
Has anyone come across any toolbox or utility for doing this from Matlab? I
searched the web but (surprisingly) didn't find anything that would do it
directly from Matlab.
G-code programs I've looked at don't appear that difficult, so I may just
write my own but thought I would check here first (and possibly avoid
reinventing the wheel).
Thanks for any help/advice.
"Pat" <pkelecy(removethis)@insightbb.com> wrote in message <IICTe.332187$xm3.93865@attbi_s21>...
> Hello all,
> I need to generate g-codes for some path profiles that I've generated in
> Matlab.
> Has anyone come across any toolbox or utility for doing this from Matlab? I
> searched the web but (surprisingly) didn't find anything that would do it
> directly from Matlab.
> G-code programs I've looked at don't appear that difficult, so I may just
> write my own but thought I would check here first (and possibly avoid
> reinventing the wheel).
> Thanks for any help/advice.
> Pat
I used Eulers Best approximation method to do the integration along X, Y, and Z and used the points as G-Code values between desired functions. Since complex design will require a collection of multiple functions I just did each part by part. dx, dy, dx become the small increments along the tool path. Hectic but it worked as an experiment. At the end you have to output the data as excel file and edit as necessary to add other unique feature such as tool change, speed and FR.
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Pet Sitter in San Antonio
Hello, I am a dog sitter/ Walker Dog sitting prices depends on size of dog Puppies-20 a day/night small dogs- 25 a day/night Medium/ Large dog- 35 a day/night. Dogs Must get along with other dogs and be house broken. Dog Walking is 10 an hour for up to two dogs then an additional 10 an hour for anymore then two dogs. I take them to park or though neighborhoods close to your location. If you are interested please text only at 978-533-.... Thank you and have a great day!
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text: Posted November 7, 2013 I believe Rivera has finally turned the corner. Very refreshing to hear him put aside his ego, and speak so candidly about it. Also, if you don't read the article in the OP, you are doing yourself a disservice. Share this post Link to post Share on other sites


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Vase and Apathocary Jar Filler Ideas
I have been searching the internet high and low for vase filler ideas. I have a small addiction with vases, ceramics, and apathocary jars. I saved all my internet photos on my desktop but then decided to share them with you.
I have not linked any of these photos to their original websites as I can't remember where they came from. If you see a photo on here that is yours, please comment and I can link to your site.
How GORGEOUS is this?? I am sure you could buy the moss at a dollar store and the eggs could be bought during the Easter season anywhere! What a simple yet fantastic idea!!!!
So fresh and simple!! Love the idea of not over filling the apathocary jars.
For The Bathroom
Again, not overstuffed with objects. Love the soap collection idea.
Keeping everything the same color creates a cohesive look - stunning!
Holiday Ideas
I have been this for a few years now, just fill any size vase with holiday ornaments. It doesn't get any easier than that! Walmart sells inexpensive boxes of gorgeous colors.
LOVE the touch of ribbon - I will definitely be adding ribbons this year to my vases!
More ribbons - you could really make a statement doing this on your mantel, side table, or main dining table.
Love the rustic look. By stacking vases one of top of each other, you have a completely different look - faboulous!!!
Simple yet elegant - filling vases with lights. You can now buy led lights that have a small battery pack in them - no messy cords!
Use salt or sugar to fill vases - such a great inexpensive idea!
Another cranberry idea - doesn't it look warm and inviting?
Christmas candies - a perfect way to welcome the holidays. How festive!!
Simple pepples and candles.
LOVE the fresh leaves in water on the right hand side.
Simple twigs in salt.
So adorable! Using apathocary jars as terreriums - the things people think of!
A vase within a vase - fill smaller vase with stones and use a sprig of leaves around it - LOVE IT!
A nice way to display plant cuttings.
Perfect for Autumn.
A splasch of color.
Plenty of options - you could use candies or coffee beans too.
I LOVE this photo. I watch Sweet Genius and Chef Ron's kitchen has jars of colored sugars - I think that would be great displayed above kitchen cupboards.
I also have an apathocary jar in my dining room that is screaming to be filled with black gumballs.
Use your imagination - you can put pretty much anything on display!!! Have any more ideas - I would be thrilled if you left me a comment.


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The Nuru massage is under renovation, but that doesn't stop client Lucas Frost from getting his needs taken care of. When he walks in he is greeted by construction worker Ryder Skye, who gives him the bad news that no one is around to help him out. But Lucas convinces her that she can be the one to ease his pain. She tells him she has no clue how to even begin, but Lucas is adamant about his a specific area, and he's more than happy to guide her through every step along the way. He guides Ryder toward the shower where she lathers his body with soap and they begin kissing passionately. They then proceed to the bathtub where Ryder is told that other masseuses stroke their clients cocks and sometimes give blowjobs. With a little encouragement, Ryder gets the hang of things, sexually pleasing Lucas more than she thought she could. When they end their amateur Nuru massage with his big hard cock in her tight pussy and a huge wad of hot cum on her stomach, this construction worker may just change career paths!
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Breeding Cycle for Goats
Goats have a very specific breeding cycle, which begins at puberty and continues as the does -- female goats -- go into heat, mate with bucks -- male goats -- and reproduce. The breeding cycle culminates in a kid -- a baby goat. Goat breeding cycles follow a regular, careful schedule.
Goats are seasonally polyestrous, which means female goats can only breed with males during the fall. This schedule ensures that the does give birth during the season -- four to five months later -- when environmental conditions are optimal for kid survival. This seasonality is primarily affected by day length, as well as temperature and rainfall, and breeding seasons vary by location -- the exception being tropical goats, who are largely unaffected by seasonal variations. In the northern hemisphere, the breeding season ranges from August to January, with kids being born in late winter or spring.
Female goats can begin to be bred when they weigh around 60 lbs. -- typically reached when they are between 7 and 10 months old. Male goats reach puberty between 4 and 8 months and can also be bred between 8 and 10 months old. One buck can breed anywhere from 20 to 30 does. Female goats go into heat -- meaning they will accept the buck for copulation -- numerous times throughout the mating season. Goat heat, or estrus, comes in cycles; estrus lasts for 24 to 48 hours, and if the doe fails to conceive during this time, estrus will occur again 18 to 21 days later.
Once the female goat conceives, gestation lasts 145 to 155 days, a four to five month period which leads to birth during late winter or early spring. The hormone progesterone, which sustains the pregnancy, is produced in the doe by the corpus luteum -- a structure on the goat's ovary. Stress can interfere with the corpus luteum, leading to miscarriage of the pregnancy; common doe stressors include being harassed by dogs, proximity to strange animals or poor nutrition. During the final month of pregnancy, the doe should receive increased crude protein and decreased calcium to prevent milk fever following the birth.
Female goats produce colostrum, which contains antibodies, vitamins and minerals that are important to kid nutrition. The antibodies in colostrum protect the kids from infection -- including infection that can be created from its mother's dirty teats. Kids born in late winter and early spring will be strongest due to prime grazing conditions. The breeding cycle begins again as kids begin to mount other kids at just 7 days old -- and male and female goats should be separated beginning around 3 months old.


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PITTSBURGH: The Pittsburgh Chapter of the International Women's Forum (IWF), a global organization comprised of more than 6,500 dynamic women leaders in thirty-five countries and seventy-six forums around the world, has provided financial funding to help support the 2017 Elsie Hillman Chair in Women and Politics event. The gift was made in honor of Elsie Hillman, who passed away in 2015.
Chatham News
Pittsburgh's International Women's Forum Provides Funding in Support of the 2017 Elsie Hillman Chair in Women & Politics
Chatham Partners with Allegany College of Maryland on 2+2 Bachelor of Sustainability
PITTSBURGH: Chatham University and Allegany College of Maryland (ACM) have entered into a partnership that enables ACM students to complete a bachelor's degree in sustainability through Chatham's Falk School of Sustainability & Environment.
Housed at Chatham's 338-acre Eden Hall Campus, the Falk School is the world's first academic community built expressly for the study of sustainable living, learning and development.
Thanks to the "two-plus-two" agreement between the two institutions, ACM students who graduate with an associate degree in biology can transfer seamlessly into Chatham's bachelor's program in sustainability.
Chatham University Earns National Recognition at Colleges of Distinction
PITTSBURGH: Chatham University announced that it has earned recognition as a Colleges of Distinction for its innovative application of high impact educational practices.
Schools must demonstrate results across the Four Distinctions—Engaged Students, Great Teaching, Vibrant Community, and Successful Outcomes. High school counselors and educators make nominations, and each school is evaluated on key indicators including student engagement, student empowerment, and curricular innovation. Colleges that have distinguished themselves in each of the Four Distinctions and that have demonstrated dedication to enriching student outcomes through innovative learning opportunities are then invited to join Colleges of Distinction.
Chatham University Professor Publishes Memoir, Schedules On-Campus Reading for November 9
PITTSBURGH: Mark Nieson, associate professor in the MFA Creative Writing program recently published a memoir, Schoolhouse: Lessons on Love & Landscape, which concerns the search for where identity, place, and heart intersect. The memoir opens with its Brooklyn-born narrator standing on his head outside an old one-room schoolhouse amid 500 acres of remote woodlands in Iowa, his new home. Why this Walden-like retreat? Is it to attend the renowned Iowa Writers' Workshop, or is he actually on the lam from love?
Nieson will be giving a number of readings in the Pittsburgh area this fall, including one on the Chatham's Shadyside campus on November 9 at 8 p.m. along with Jenny Ashburn, Alison Taverna & Dakota Garilli, three recent MFA graduates who also have books/chapbooks coming out.
Chatham University to Host Thinking Bigger than ever: Women in 2016
PITTSBURGH: On November 10-12, Chatham University will host Thinking Bigger Than Ever: Women in 2016. Thinking Bigger is a three-day conference featuring speakers and networking opportunities focused on women's leadership, entrepreneurship, and gender equity. Conference events include:
- Thursday, November 10, 5:30-7:45 PM
The opening reception and a post-election analysis panel from the Pennsylvania Center for Women and Politics (PCWP)
- Friday, November 11, 7:30 AM to 10:00 AM
An entrepreneurship breakfast with Small Business Administration District Director Kelly Hunt and Filmmaker JulieHera DeStefano, hosted by the Center for Women's Entrepreneurship (Center) and its Chatham's Women's Business Center (CWBC)
- Saturday, November 12, 8:30 AM – Noon
A symposium of gender scholars entitled "Gender and Violence: Connecting Interdisciplinary Scholarship and Community" hosted by the Women's Institute
Thinking Bigger 2016 is a collaboration between the Chatham University's Women's Institute, Pennsylvania Center for Women & Politics, and the Center for Women's Entrepreneurship with its Chatham's Women's Business Center.
More information, speaker bios and registration available at www.thinkingbigger2016.com.
Chatham Places as 2nd Overall Performer in Master's Institutions in the 2016 Sustainable Campus Index
Pittsburgh: Chatham University has achieved second place in Master's Institutions' Overall Top Performers category in the 2016 Sustainable Campus Index, a publication by the Association for the Advancement of Sustainability in Higher Education (AASHE). Chatham earned the second highest gold level rating with an overall STARS score of 75.8, with only one university earning the highest platinum level rating. Chatham also tied for first place in the Grounds category, which highlights achievement in campus land management and biodiversity of campus grounds and surrounding lands.
The 2016 Sustainable Campus Index recognizes top-performing colleges and universities overall and in 17 distinct aspects of sustainability, as measured by the Sustainability Tracking, Assessment & Rating System™ (STARS).
STARS is a transparent, self-reporting framework for colleges and universities to measure their sustainability performance developed by AASHE. With nearly 800 participating institutions, STARS is the leading tool for measuring higher education sustainability performance. 124 reports were submitted in the most recent calendar year, resulting in an 11 percent increase over the previous year and a third consecutive year of growth.
The Falk School of Sustainability at Chatham University Announces the 2016-17 Speaker Series
PITTSBURGH: The Falk School of Sustainability & Environment will host a broad range of speakers during the 2016 Fall Semester. All events will take place at 2 p.m. at the Esther Barazzone Center on the Eden Hall campus in Richland, PA. Events include:
October 28
"The Budding Aromas from Taco Trucks: Taste and Space in Austin, Texas" will feature Robert D. Lemon, MCRP, MLArch, PhD, department of geography University of Texas, Austin on October 28. Lemon is a visiting professor for Human Geography at the Institute of Geography and the Heidelberg Center for American Studies at Heidelberg University. He is a cultural and urban geographer with a passion for landscape studies. As an urban geographer and environmental designer, he has studied extensively the social practices and built transformations of cities through their aesthetic representation.
Author Alice Walker to speak at premiere of Pittsburgh filmmaker's new film
PITTSBURGH: On Thursday, October 27, Pulitzer Prize winning author, Alice Walker, will be in Pittsburgh to speak at the premiere of a film which she narrated. The film, "Yemanja: Wisdom from the African Heart of Brazil," is by Pittsburgh Filmmaker Donna Roberts and will be screened as part of the Just Films series, sponsored by the Chatham University Women's Institute, New Voices Pittsburgh, the Women and Girls Foundation, and the Women's Law Project.
Ms. Walker will speak on a panel following the screening in the Campbell Memorial Chapel on Chatham University's Shadyside campus at 6:30 p.m. Overflow seating is in the Eddy Theater. The event is free and open to the public with registration at www.justfilmspgh.org.
Lead support for this event is generously provided by Eden Hall Foundation.
Chatham University Named to the Princeton Review's Green Honor Roll
PITTSBURGH: Chatham University has been selected as one of only 21 universities around the country for the Princeton Review's Green Honor Roll, which recognizes the most environmentally responsible colleges across the United States. Chatham earned a perfect Green Rating score 99 out of 99, which measures "a school's performance as an environmentally aware and prepared institution".
Chatham University is also profiled in Princeton Review's free downloadable book, "The Princeton Review's Guide to 353 Green Colleges", which profiles institutions of higher education that demonstrate notable commitments to sustainability in their academic offerings, campus infrastructure, activities, and career preparation.
New film Series, Just Films, Inspires Audiences to Action
PITTSBURGH: Ten new social justice films, most screening for the first time in Pittsburgh, will be presented as part of the new Just Films series which debuted in September. The Just Films series is the brainchild of four organizations committed to women, girls, gender equity, and social justice: the Chatham University Women's Institute, New Voices Pittsburgh, the Women and Girls Foundation, and the Women's Law Project.
As part of the series, one film a month will be shown on Chatham University's Shadyside campus from September 2016 through June 2017. Films will be free and open to the public. Visit the Just Films website for the schedule and list of films.
Join us on October 27th, for the next film in the series: Yemanjá: Wisdom from the African Heart of Brazil. The film is narrated by Alice Walker, Pulitzer Prize-winning author of The Color Purple, who will be our special guest panelist following the Pittsburgh premiere.


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By Anthony Breznican, USA TODAY
If the Golden Globe nominees shook up award season two days ago, then the Screen Actors Guild provided a mild aftershock today.
While most of the contenders are the same, there are some notable exceptions.
Up in the Air, which led the Globe nominations with six, was among the top contenders for the SAG Awards, too. It tied with Inglourious Basterds and Precious: Based on the Novel Push by Sapphire with three each.
THE NOMINEES: See who's up for what
LIFELINE LIVE: More on the Screen Actors Guild nominations
But while Basterds and Precious both received bids for best ensemble, the acting guild's version of best picture, Up in the Air was snubbed in that category.
The other contenders were the 1960s London coming-of-age story An Education, the musical romance Nine and the brutal Iraq war bomb-defuser saga The Hurt Locker.
With actors making up the largest voting bloc for Oscars, the Holy Grail of awards season, being left out of their guild's choice of best picture is a disappointment for Up in the Air. Nonetheless, writer-director Jason Reitman's story of a corporate downsizer trapped in a life of constant travel picked up more individual nominees than any other film.
A lead actor nomination went to star George Clooney, while supporting actress bids were given to co-stars Anna Kendrick and Vera Farmiga.
Precious, a drama directed by Lee Daniels about an overweight, abused black teenager trying to survive amid horrible circumstances, split its other two nominations between newcomer Gabourey Sidibe for lead actress and Mo'Nique, who played her psychotically abusive mother, for supporting.
Sidibe's competition for lead actress is Sandra Bullock for The Blind Side, Helen Mirren for The Last Station, Carey Mulligan's independence-seeking teenager in An Education, and Meryl Streep as Julia Child in Julie & Julia.
All were nominated for Globes, except Streep was in that award's musical/comedy category for Julie & Julia.
Meanwhile, Clooney will face off for a lead-actor award with Jeff Bridges' alcoholic country singer in Crazy Heart, Colin Firth as a gay professor in A Single Man, Morgan Freeman's take on Nelson Mandela in Invictus, and Jeremy Renner as a bomb-squad technician on the edge in The Hurt Locker.
Those nominations were exactly the same as the Globe contenders for lead-drama actor, except for Renner. Instead, a Globes nomination went to Tobey Maguire in that category for Brothers.
Basterds, Quentin Tarantino's history-bending romp through World War II, collected a supporting-actress mention for Diane Kruger's German starlet working as an American double-agent, and Christoph Waltz's bon vivant villainous Nazi.
In addition to Kruger, Kendrick, Farmiga and Mo'Nique, Nine's Penelope Cruz is also in the supporting-actress race. The difference from the Globes was again only a single nominee — Kruger got the bid instead of Julianne Moore, who is up for a Globe for A Single Man.
In the supporting-actor race, the two award shows matched up precisely. Waltz's opponents in both are Matt Damon for Invictus, Woody Harrelson for The Messenger, Christopher Plummer for The Last Station, and Stanley Tucci for The Lovely Bones.
Directors Tarantino, Daniels and Reitman are not among the nominees, but it's not a snub. The Screen Actors Guild only recognizes performers, not the other contributors to the filmmaking process.
The 16th annual Screen Actors Guild Awards will be simulcast nationally on TNT and TBS on Jan. 23.
Guidelines: You share in the USA TODAY community, so please keep your comments smart and civil. Don't attack other readers personally, and keep your language decent. Use the "Report Abuse" button to make a difference. Read more.


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- Worldwide Rank #138,457,746
- Follower/Following Ratio 0.28
- Daily New Followers 0
ضي Twitter Stats
@01_dhay - Tracking ضي Twitter profile since October 1, 2015
- Small designer
ضي's story
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The plot thickens when considering ضي's follower-to-following ratio, which is 0.28.
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ضي Tweets
@01_dhay has posted 0 tweets in the last 5 days, which translates to an average of 0 tweets per day.
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@01_dhay has 44 followers on Twitter.
This account is #138,457,746 in the worldwide rank of the most popular Twitter users.
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Last month this account followed 70 users.
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We help you locate a Isle Of Canna viola tutor. Viola tuition are a great way to begin a fun new hobby, pick up a new skill and gain confidence in viola. Please use our site to find Isle Of Canna viola tutors and determine which suits your needs so you can start your viola lessons in Isle Of Canna today!
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It may not be the flagship we have been waiting for but HTC have launched the Desire 320- an entry level 3G phone that promises to deliver a double whammy of powerful performance and beautiful build quality that we have come to expect from the design award winning manufacturer.
The successor to the HTC Desire 310, the new entrant runs on Android™ 4.4 on a Quad-core 1.3 GHz quad-core processor which should make gaming and app juggling a breeze.
The Desire 320 will be available in Vanilla White and Dark Gray with a 4.5" screen and sport a 5MP rear-facing camera. Furthermore, it comes prepackaged with HTC's Video Highlights functionality so creative-types can tinker away with mini-movie making as much as they please.
Blinkfeed makes an appearance here and the micro-SIM sporting phone also features a 1080p screen. Memory onboard is 8GB expandable up to 32GB via micro-SD card and it sports a 1GB RAM.
The 3.5G phone has a 2100mAH battery- which admittedly not the largest we know of is perfectly acceptable for an entry-level handset.
We will bring all details relating to pricing as soon as we know more and the phone will be available in the UK later in the year.


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A few weeks ago rumors started to swirl that Polo Manukainiu had committed to the Sooners. Soon after hearing the news Sooners Illustrated got confirmation from the source himself that the news was untrue. Turns out it was all just a misunderstanding.
"There is this dude that called me that said just name your top two and I said Baylor and OU and I guess he took it the wrong way," Manukainiu stated. "OU is up there though."
Is there a chance that Manukainiu could still announce his decision soon?
"Yeah to OU soon," Manukainiu said about announcing a commitment. "After I let my family know."
Based off of that comment it sounds like Manukainiu may have already made his decision and that a commitment could happen at any moment for the 6-foot-6 and 255-pound defensive end. The location of Norman is obviously playing a major factor with Manukainiu's along with the fact that a family member of his is now there, Sooner Haka sensation, Nila Kasitati.
"Just that it is close to home and I can come back. It's not too far and not too close. And plus I like the tradition and my cousin is over there."
The monstrous defensive end says his cousin has let him know that it is hard work up there in Norman.
"Oh he said its hard work but he knows that we can do it," Manukainiu explained. "It's the same stuff that we do in the summer but just harder."
Trinity came out victorious against Tyler Lee Friday Night, 30-7, despite the fact that Manukainiu and their starting middle linebacker, Brian Nance, were both out. Manukainiu is dealing with a PCL injury but expects to be back soon along with Nance.
"Me and our linebacker, Brian Nance, are coming back in three weeks." Manukainiu said.
Despite not being able to play, Manukainiu had butterflies before the game due to worrying about the defense, but seeing them earn the victory the way they did helped calm his nerves.
"At first I was nervous but my team pulled it off. Now that they are good all that nervousness went away and I can count on the defense. Our defense was struggling in practice earlier, so now that they did good all that sweat's off and I believe in them now."
In Manukainiu's absence the Trinity defensive end play was still solid thanks to a couple of 2013 defensive end prospects who the Sooners have interest in, Gaius Vaenuku and Sam Tevi. Because of their play Manukainiu says that when he returns it may be at the tight end position.
Stay with Sooners Illustrated as we will stay on top of this situation as a commitment could come at any time.


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Flashrom is a utility for reading, writing, erasing, and verifying flash ROM chips. It's often used to flash BIOS/coreboot/firmware/EFI images. It supports a wide range of DIP32, PLCC32, DIP8, SO8/SOIC8, and TSOP32/40/48 chips, which use various protocols such as LPC, FWH, parallel flash, or SPI. The tool can be used to flash BIOS/firmware images, for example, be it proprietary BIOS images or coreboot (previously known as LinuxBIOS) images. It can also be used to read the current existing BIOS/firmware from a flash chip.
noVNC is a VNC client implemented using HTML5 technologies, specifically Canvas and WebSockets. It supports "wss://" encryption (SSL/TLS). For browsers that do not have native WebSockets support, the project includes web-socket-js, a WebSockets emulator using Adobe Flash. In addition, as3crypto has been added to web-socket-js to implement WebSocket SSL/TLS encryption, i.e. the "wss://" URI scheme.
A free H.323 gatekeeper.
Structure parameter inference approach for endocrine feedback control.


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Korpos sounds like a genius. It's pretty incredible what a person can accomplish when they have passion and motivation!
A police taser that had no effect? That sounds like BS to me. Crossing jurisdictional lines while off duty and being involved in a shooting sounds even more like BS. Police in this area get away with murder on a consistent basis. A man was shot by police in front of my sisters house. The police officer handed a drop pistol to his buddy while in a police car and it was caught on tape and he ended up getting a medal. There are really good officers. It's a tough job. But being a cop isn't a license for murder, no matter what the circumstances are.
My view of Randy has been completely altered thanks to this article. He seems like a very intelligent man that cares about the city of Cleveland. I didn't know he grew up in Cleveland. If possible donate to Hattie Larlham. The children with special needs there would appreciate the help :)
I thought we lived in the USA not the Soviet Union...my mistake.


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Matthew Hall <mh...@informatics.jax.org>
|Re: Multiple Analyzer on Single field
|Mon, 06 Apr 2009 16:41:27 GMT
... erm.. I'm still not quite sure what you are talking about. But what you are trying to do, really isn't that hard. Here's some sample code that should get you to where you want to be: During document creation time do something like this: doc.add(new Field("data", /data/, Field.Store.YES, Field.Index.TOKENIZED)); doc.add(new Field("sdata", /data/, Field.Store.YES, Field.Index.TOKENIZED)); Repeat for as many times you want the same data to be searchable via a different analyzer. Then at indexWriter time do something like this: PerFieldAnalyzerWrapper aWrapper = new PerFieldAnalyzerWrapper( new StandardAnalyzer()); aWrapper.addAnalyzer("data", new /AnalyzerForDataField/); aWrapper.addAnalyzer("sdata", new /AnalyzerForsdataField/); writer = new IndexWriter(INDEX_DIR, aWrapper, true); Again repeating for each field you want searchable via a different analyzer. At search time, make sure your query parser uses this same PerFieldAnalyzerWrapper, and you will be all set. Well.. unless I really didn't understand what you were trying to do here... There's always that possibility. Matt Douglas Campos wrote: > What I've done is to put copies of the same field, built with different > analyzers, and later use a MultiFieldQueryParser matching all fields. > > eg: "name", "name_phonetic", "name_keyword", ad nauseum > > To define which analyzer will go to which field, use PerFieldAnalyzerWrapper > > On Mon, Apr 6, 2009 at 11:52 AM, Allahbaksh Mohammedali Asadullah < > email@example.com> wrote: > > >> Hi, >> I want to add multiple Analyzer on single field. I want properties of >> KeywordAnalyzer, SimpleAnalyzer, StandardAnalyzer, WhiteSpaceAnalyzer. Is >> there any easy way to have all analyzer bundled on single field. >> Regards, >> Allahbaksh >> >> >> >> >> >> >> >> **************** CAUTION - Disclaimer ***************** >> This e-mail contains PRIVILEGED AND CONFIDENTIAL INFORMATION intended >> solely >> for the use of the addressee(s). If you are not the intended recipient, >> please >> notify the sender by e-mail and delete the original message. Further, you >> are not >> to copy, disclose, or distribute this e-mail or its contents to any other >> person and >> any such actions are unlawful. This e-mail may contain viruses. Infosys has >> taken >> every reasonable precaution to minimize this risk, but is not liable for >> any damage >> you may sustain as a result of any virus in this e-mail. You should carry >> out your >> own virus checks before opening the e-mail or attachment. Infosys reserves >> the >> right to monitor and review the content of all messages sent to or from >> this e-mail >> address. Messages sent to or from this e-mail address may be stored on the >> Infosys e-mail system. >> ***INFOSYS******** End of Disclaimer ********INFOSYS*** >> >> > > > > --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: firstname.lastname@example.com
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This property is no longer available.Search for Available Property.
2.07 acres in Yavapai County, Arizona
If you are looking for beautiful open spaces with public lands all around then this is the acreage for you! Flat to gently rolling hills with several great building sites. Bring the horses! Area of site built homes only and privacy abounds. In area with lots of vegetation and beautiful tree filled views. Parcel 306-47-019E also available if you need more room to spread out.
From Hwy 89 LEFT W Rd 5 N. to Yuma. Cross cattle guard follow R on Yuma. Left on Cedar Heights to top of hill, R on Spruce, stay on Taro Ln. Follow to Spotted Dog Tr. Left to Sign on Property.
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text: \nFast Breaks: Pistons-76ers\nBy Ian Thomsen\n\n\n\n \n\n\n\nGame 3\n \nLeaders\n\n\nSixers lead series 2-1\n \nPoints\nRebounds\nAssists\n\n\n\t\n\n(7)\n (2)\n\t\t\n\n\nBox Score\t\n\n\nRecap\t\n\n\nPhotos\t\n\n\nComments\t\n\n\t\t\n\n95\t75\t\n\n\n \n\t\n\n\tHamilton\n\n23\n\n\n\t\n\n\tDalembert\n\n16\n\n\n\t\n\n\tGreen\n\n6\n\n\n\n\n\n\nAP\n\n This loss was a huge shock for the Pistons, who are seeking to reach the Eastern Conference finals for a sixth straight year. Detroit was 21 for 34 overall (61.8%) when Richard Hamilton made a three-pointer 79 seconds into the second half -- and that turned out to be the Pistons' last basket of the third quarter. They didn't make a field goal over the last 10:41 of the period, as Philadelphia steadily added 13 points to its lead, making it 70-55 entering the fourth. A more experienced team than Philly would have built the lead into the mid-20s; nonetheless, the difference between the visitors and their hosts in terms of energy, athleticism and ambition was staggering. Tayshaun Prince (8-of-9 for 18 points) and Hamilton (23 points on 18 shots) were Detroit's only sure things offensively, and Hamilton missed five minutes of the decisive third quarter with foul trouble. No. 7 seed Philadelphia leads the series 2-1 despite the ongoing struggles of star Andre Iguodala (right), who is 11-of-30 from the field with 12 turnovers, offsetting his 18 assists. "Andre's going to be fine," said 76ers coach Maurice Cheeks. "We're going to keep putting the ball in his hands." This was the Pistons' sloppiest game of the year, by far. They led the league in fewest turnovers with 11.66 per game while never committing more than 18 this season; on Saturday, they suffered their 19th turnover with 15:32 remaining. They finished with 25 turnovers, leading to 29 Philadelphia points. "They put pressure on us and we turned the ball over," said Detroit coach Flip Saunders. That carelessness created pressure on the Pistons to be efficient with their shooting, which in turn, contributed to their 8-for-35 (22.9 percent) performance in the second half. They missed numerous open jumpers. "When you're losing shot opportunities, those shots become bigger shots because you're not getting as many," said Saunders. "I've got to do a better job to get our guys better shots . Evidently, we didn't put them in a situation where they felt comfortable and they could be successful." Pistons power forward Antonio McDyess suffered a broken nose and may not be available for Game 4 Sunday in Philadelphia. "He's one of our high-energy guys," said Prince, which is bad news for a team that was outworked and outrun throughout Game 3. "Our guys -- [backup forward Jason] Maxiell -- have to be ready in case 'Dyess doesn't play. Everybody has got to be ready to play ... We've allowed ourselves to get in this position as far as not matching their energy in every game." Rasheed Wallace had two points, five rebounds and four turnovers in 34 minutes and was thoroughly outplayed by 76ers center Samuel Dalembert, who went for 22 points and 16 rebounds after shooting 18.8 percent in the first two games. A similar mismatch emerged at point guard, where Chauncey Billups gave Detroit 11 points (2-for-11) with four assists and three turnovers while being exploited by Andre Miller (21 points, 3 assists) while providing firm leadership and consistently pushing the ball. Detroit looked old and confused against the 76ers' relentless pressure, but don't expect the Pistons to suffer another blowout Sunday. It would be no surprise to see them control tempo and reclaim homecourt advantage heading back to Detroit for Game 5. The real question raised by this loss is whether the Pistons are capable of making a run at the NBA Finals. Is it not too late to regain their edge, or does this humiliating rout signal a third straight underperforming postseason followed by another summer of wondering what went wrong? \n\n\n\n\n \n\n


text:
login with
Captain Mom I Need You!!!
Im looking for a job online and as you know this is one of the hardest secrets in the business known to man...well woman rather... I need the superpowers from experienced mothers and online junkies. Please help!!! I need a job with no start up fee and possibly typing with no experience needed for at the least. Please!! Thank you and I love you guys so much in advanced
It is hard to find a lucrative job that requires no skill... i find that most online jobs require some kind of skill...whether it be typing, word processing, customer service, etc.
There is a great site that might help: alpineaccessjobs.com
There is a great site that might help: alpineaccessjobs.com
I'm going to let you all know which one/ones sparked my brain juices by the end of tonight. Stay tuned!.....
I knew I could depend on the fellow Mother Bears!!! I love you girls so much!
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text:
A modern classic.
Delivery time: 3-5 DAY
Aboca Museum presents the new edition of its artistic diaries.For 2017, its pages are adorned with elegant plates from Erucarum ortus, alimentum et paradoxa metamorphosis.Much more than a mere aide-mémoire…
The history of botany and the spotlighting of its rarest and most precious aspects has always been a part of Aboca's mission.Erucarum ortus, alimentum et paradoxa metamorphosis, which was printed in Amsterdam in the 1720s, contains one of the best-known studies of botany and entomology of the Age of Enlightenment.It owes its fame to the extraordinary artwork of Maria Sybilla Merian, a gifted painter and intrepid naturalist who overturned the conventions of the rigidly male world of the Dutch scientific community. Her conviction that every species should be painted in its natural environment led her to undertake an adventurous expedition to the forests of Suriname, to see for herself the metamorphosis of the caterpillars that populated the area.
The originals of the plates reproduced in the 2017 diary can be found in the Aboca Museum's Bibliotheca Antiqua.While copies of the work normally contain black and white engravings, Aboca's specimens stand out for their delicate use of contemporary watercolour.
The selection of flowers in the Botanical diary, Aboca 2017 collection
- Cover: French hollyhock (Malva folio hederaceo)- January: Pear tree (Pyrus prafina, florens)- February: Common mallow (Malva)- March: Indian cress (Nasturtium indicum)- April: Broad lived purple iris (Iris hortensis latifolia)- May: Rosa mundi (Rosa versicolor)- June: Mountain pansy (Viola lutea, pleno flore)- July: Sweet violet (Viola martia purpurea)- August: Gold red lily (Lilium aureum)- September: Cabbage rose (Rosa centifolia, batavica, rubra)- October: Morning glory (Convolvulus)- November: Sowbread (Cyclamen flore purpureo)- December: Windflower (Anemone, flore coccineo)
17,5 x 24,5 cm
cartonata semirigida su carta patinata opaca
Tela sul dorso, con impressione a secco in prima di coperta
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Mazes Chicago, Illinois
Chicago's Mazes (the original Mazes, mind you, not the British wankers who stole the name) have release 2 or 3 albums, depending on who you ask. Mazes is made up of three multi-instrumentalists, Edward & Caroline from The 1900s and their peculiar friend Charles d'Autremont, aided & abetted by bassist Tom Smith (ex-Office and Old Fake), and drummer Pat Cavanaugh. ... more
Streaming and Download help


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63" Leaf Spring ?s
Discussion in 'The Garage' started by tlspeed, Apr 3, 2006.


text:
Convert an existing OsCommerce website to be mobile responsive as well as upgrade to latest version of oSCommerce
Budżet $250-750 USD
I would like my website to be upgraded to the latest version and updated for mobile... My site is built in the oscommerce platform. We use paypal for payment processing and have more than 100 products. The shopping cart works just fine could use a few tweaks as well as make the site google friendly and allow customers to order via their mobile device. Thank you
37 freelancerów złożyło ofertę na średnią kwotę w wysokości $543 do tego projektu.
Hi, I have read your post and understood your requirement. I have great experience working on /osCommerce/Magento/WooCommerce/HTML5/jQuery/Shopify/Prestashop/VirtueMart/Joomla/OpenCart/Volusion /CSS3/PHP/Drupal/Y Więcej
Please share the site url so we can check what is the current version of your site and can let you know that it is possible to upgrade or not. We have a team of designer which can convert your site fully mobile devi Więcej
I have read your requirements and think that I would be a great fit for this project, Ready to start
Hi there..!! I am ready to work on this project and can start work on it Immediately. May I know the url of the site ? First have a look at our previous Oscomerce work samples: ============================= Więcej
Hello, I went through your requirement and understood that you want to upgrade your website and make it RESPONSIVE. and in this you want to pay pal for payment processing and customer will give order with the use Więcej
Hello, my name is Olya. I represent Ukrainian IT Company «Webbook». We provide website design and web and app development services for organizations, public and government institutions, company or private web-pages. Więcej
Hello, I will upgrad your site to the latest version and updated for mobile as well . Expert Oscommerce Programmer I can I have been working with osCommerce since 2008 and are expert in all versions. I provide Więcej
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Dear Client, Greetings! After careful review of your website, I am ready to develop a mobile responsive and will comfortably upgrade the latest version of oSCommerce. I am a highly skilled web developer and I Więcej
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text:
Sport Mazda Orlando App
by: MobileAppLoader • 4
All Android applications categories
by: MobileAppLoader • 4
Sport Mazda's New App is Here. Down load for free today and receive special discounts/savings e-coupons direct to your phone plus the convenience of direct CHAT and App Service Appointment one touch - no hassle settings. Sport is Central Florida's New Mazda Superstore & Pre-Owned Import Outlet located just 1 Mile N. of Florida Mall specializing in New & Certified Pre-Owned Mazdas PLUS the areas BEST Selection Quality Pre-Owned.
Other features and benefits of Sport Mazda's App include:
-Qualify for special, non posted Service and Sales Coupons Savings
-Call any of our departments or roadside assistance with the touch of a button
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-Get a Quote on a New or Pre-Owned Vehicle
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Tags: appdroid sporte , sport mazda
from 4 reviews
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Citation: Conceição-Silva F, Morgado FN, Pimentel MIF, Vasconcellos EdCFe, Schubach AO, Valete-Rosalino CM, et al. (2013) Two Women Presenting Worsening Cutaneous Ulcers during Pregnancy: Diagnosis, Immune Response, and Follow-up. PLoS Negl Trop Dis 7(12): e2472. https://doi.org/10.1371/journal.pntd.0002472
Editor: Mary Ann McDowell, University of Notre Dame, United States of America
Published: December 12, 2013
Copyright: © 2013 Conceição-Silva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was funded by an International Joint Project Grant (2008/R3) from The Royal Society, United Kingdom, The Royal Society and The Wellcome Trust (07664/Z/05/05/Z, PK), United Kingdom, as well as IOC (POM 2010–2011) and IPEC (PA2010)-FIOCRUZ, FUNASA/MS, CNPq (470886/2003-0); PROEP-CNPq 402557/2011-5 and FAPERJ (E26.111.717/2012), Brazil. AOS is the recipient of fellowships from CNPq and FAPERJ, Brazil. The funders had no role in study design data collection and analysis, decision to publish, or preparing the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Description of Cases
Two pregnant patients (PP) presenting cutaneous ulcers were referred to our outpatient clinics at Instituto de Pesquisas Clínicas Evandro Chagas (IPEC)–Fiocruz. The first patient (PP1, 24 years old) had an ulcer above the knee (35×25 mm). The second patient (PP2, 25 years old) presented an ulcer (22×17 mm) on the left arm. Lesion onset occurred approximately 2 months earlier in both patients, and both were 2–3 months pregnant. As they lived in areas endemic for American cutaneous leishmaniasis (ATL) and sporotrichosis (SP), specific tests for ATL and SP (lesion biopsies: histopathology, immunohistochemistry [IHC], and parasite/fungi/bacteria isolation; peripheral blood: serology) were performed. Routine pregnancy screenings were done, and blood counts and biochemistry were within the normal range.
Diagnosis Confirmation and Follow-up
The diagnosis for both patients was localized ATL (LCL), since Leishmania parasites, characterized as Leishmania braziliensis, were isolated from lesions, whereas isolation of fungi and bacteria (including mycobacteria) was negative. This was confirmed by histopathology and IHC. As the patients were pregnant, specific anti-leishmanial treatment was not started, and the patients were monitored monthly. The lesion of PP1 increased in size (50×37 mm) and became ulcerative-vegetative at 5 months of pregnancy, and towards the end of pregnancy (8–9 months), small satellite ulcers appeared (not shown) around the main lesion (54×40 mm) (Figure 1 PP1-A). No other skin or mucosal lesions were detected. About 2 months after delivery, the exuberance of the lesions had decreased; they became shallower and less secreting. At 3 months postpartum, satellite lesions healed, and the beginning of peripheral epithelialisation with hyper-pigmentation areas was observed (Figure 1 PP1-B). This clinical evidence of spontaneous improvement after delivery was confirmed by IHC (Figure 2). An inflammatory granulomatous infiltrate with areas of fibrosis and epithelialisation was detected. Since the patient decided to continue breastfeeding, treatment with pentavalent antimony was not started. Clinical cure occurred 3 months later, and the lesions remained healed 48 months later without any sign of mucosal metastasis.
The upper left picture shows the lesion of pregnant patient 1 (PP1-A) at 8 months of pregnancy, and the upper right shows the lesion of the same patient 3 months after birth (PP1-B). The lower left picture shows the lesion of pregnant patient 2 (PP2-A) at 6 months of pregnancy, and the lower right picture shows the lesion of this ATL patient 6 months post delivery (PP2-B). Lesions during pregnancy developed as ulcerative-vegetative (A), and post delivery, signs of lesion healing (epithelialisation, hyperpigmentation, and fibrosis) are seen (B).
The inflammatory response in the lesions was assessed by in situ immunohistochemistry. (A,B) CD8+ cells, (C,D) CD68+ cells, (E,F) NOS2, (G,H) IFN-γ, and (I,J) IL-10 expression in active lesions of pregnant ATL patient (PP1). (A,C,E,G,I) at 8 months of pregnancy; (B,D,F,H,J) at 2–6 months post delivery; Magnification: 200× (bar = 50 µm); arrows indicate examples of positive areas.
The lesion of PP2 also developed as ulcerative-vegetative and increased in size until 6 months of pregnancy (40×26 mm), when the lesion size stabilized (Figure 1 PP2-A). At 2 months postpartum, the area measured 27×20 mm; it was epithelialised and completely healed 6 months postpartum (Figure 1 P2-B). At this time, histopathology showed the presence of fibrous tissue with focal residual inflammatory cells, and no parasites were detected. The patient did not receive specific treatment, and 12 months after delivery, the area presented an atrophic scar measuring 26×25 mm. No signs of mucosal lesions were detected, and Leishmania serology was negative.
Why Do ATL Lesions Tend to Worsen during Pregnancy?
The changes in innate and adaptive maternal immune responses during pregnancy are tightly linked to gestation and normalize postpartum [1]. These transient changes can have both beneficial and detrimental consequences, as exemplified by improved rheumatoid arthritis and systemic lupus erythematosus [2] and enhanced susceptibility to infection or aggravated disease during pregnancy [3]. However, understanding of the impact of parasitic diseases on mother and infant is still limited.
Some aspects of the maternal immune response to Leishmania spp during pregnancy have been studied in animal models and showed that Leishmania-infected pregnant C57BL/6 mice developed larger lesions, harbored increased parasite burdens, and expressed less IFN-γ but increased levels of IL-4, IL-5, and IL-10 as compared to nonpregnant controls [4], [5]. In this model, IFN-γ and TNF-α production by placental cells correlated with fetal resorption and implantation failure [6]. These data suggest that anti-leishmanial Th1 responses could adversely affect the success of pregnancies, either by interfering with placental development and maintenance and/or by impairing preimplantation events. These results imply that the modulation of maternal immune responses during pregnancy favors parasite growth and lesion development. Furthermore, control of Leishmania panamensis infection during pregnancy in a hamster model was mostly due to innate immune responses, including enhanced estrogen-mediated up-regulation of NOS2 expression and NO production [7].
Human pregnancy has been associated with a shift in Th1/Th2 balance, and pregnant woman exhibit reduced type 1 responsiveness, which is considered to be important for healing in leishmaniasis. Indeed, atypical manifestations and worsening of LCL during pregnancy is consistent with this interpretation, but the mechanism is not fully characterized.
Can We Detect Changes in Immune Responses of Pregnant ATL Patients?
To answer this question, we tested local (lesion) and systemic (blood) immune responses. Punch biopsies from cutaneous lesion (5–6 mm) and/or peripheral blood samples (EDTA) were collected in the second, fifth, and eighth month of pregnancy and 2–6 months after delivery. We also tested tissue and blood from six nonpregnant, age-matched ATL patients before treatment (Table S1), as well as peripheral blood of ten healthy, age-matched female volunteers (25.5±0.93 years).
This study was approved by the Ethics Committee in Human Research (CEP–IPEC–Fiocruz–number 014/2001). All participants gave written informed consent.
The in situ inflammation was evaluated by IHC as described [8] at the eighth month of pregnancy and at 2–6 months postpartum as well as in the nonpregnant ATL group before treatment (Figure 2, Table S2). Despite similarities in organization and architecture of the inflammatory site during pregnancy and after birth, the concentration and distribution of some cell types and secretory products changed in both pregnant patients after delivery. T lymphocytes and macrophages were abundant at both times (Figure 2A–2D). Postpartum, a pronounced increase in both extent and number of NOS2 positive areas was detected (Figure 2E–2F). In accordance with increased NOS2, parasites were no longer detectable in the lesion postpartum (Figure 3 upper panel). Although the distribution of IL-10 positive areas remained similar on two occasions (Figure 2I–2J), there was an increase of IFN-γ positive areas postpartum (Figure 2G–2H). At the same time, an increase in the percentage of B cells, neutrophils, Bax+ cells, CD25+, and Foxp3+ cells was observed. However, Bcl-2+ and Ki-67+ cells were reduced. In the eighth month of pregnancy, the patients expressed less IFN-γ than nonpregnant female ATL patients (Table S2).
Amastigotes present in the lesions were enumerated by in situ immunohistochemistry in active cutaneous lesions of both pregnant patients (PP1, PP2) before treatment, in the eighth month of pregnancy (gray bars) and 2–6 months after birth (black bars). Amastigote numbers present in lesions of nonpregnant ATL patients (average of three patients) before treatment are shown as comparison. The results are expressed as number of parasites per mm2, using a grid-scale consisting of 20×20 subdivisions in an area of 10 mm2×10 mm2, adapted to slides as previously described [24]. The results shown are median ± SEM. n.d. = not detectable; (Lower panel) Serum arginase activity. Arginase activity (U/mL) was determined in sera obtained from peripheral blood of pregnant ATL patients collected at 3, 5, and 9 months of pregnancy (black bar PP1; grey bar PP2) as well as four age-matched nonpregnant ATL patients (hatched bars). The results shown are median ± SEM.
The enzymatic activity of arginase present in serum was measured as previously described [9]. The enzyme arginase, chiefly expressed in human neutrophils and macrophages, catabolizes its substrate L-arginine, and under certain conditions, increased arginase activity causes reduction in L-arginine levels in the extracellular fluid. Reduced availability of L-arginine can impair T cell responses and weaken immune responses against infection [10]. We previously reported enhanced arginase activity in pregnant women and wished to test the hypothesis that worsening of leishmaniasis in pregnancy is associated with increased arginase activity [9]. Results presented in Figure 3 (lower panel) show that in both pregnant patients, arginase activity increased during pregnancy and declined at time of birth to levels similar to those observed in ATL nonpregnant controls.
Antigen-specific cytokine secretion by PBMC was assessed by ELISPOT assay at 8 months of pregnancy and 2–6 months after birth, as well as in nonpregnant ATL patients before treatment and in healthy volunteers. IFN-γ secretion was decreased in both patients during pregnancy but increased postpartum, reaching values comparable to those seen in untreated nonpregnant ATL patients (Figure 4A). Furthermore, high frequencies of IL-10–producing cells were detected in the absence of antigen that decreased following antigenic restimulation in ATL patients and in ATL pregnant patients after birth. However, antigen-specific IL-10–producing cells increased in response to specific restimulation during pregnancy (Figure 4B). Thus, the results obtained from lesion tissues and peripheral blood show changes in both local and systemic maternal immune responses. After delivery, the healing of lesions correlated with increased in situ NOS2 expression (Figure 2F), decreased parasite counts (Figure 3 upper panel), as well as increased systemic and in situ expression of IFN-γ (Figure 4A).
(A) The number of IFN-γ and (B) of IL-10–producing cells in peripheral blood was determined at 8 months of pregnancy and 2–6 months after birth in both pregnant ATL patients by ELISPOT assay and compared to those present in nonpregnant ATL patients before specific treatment and in healthy volunteers. Spontaneous release (black bars) as well as antigen-specific responses to restimulation with Leishmania-antigen in vitro (grey bars) are shown. The results from antigen-stimulated PBMC were expressed as the difference of the number of spots/10,000 PBMC in the antigen-stimulated wells minus the mean number of spots in control wells (with medium alone = spontaneous release) from the same donor. The results shown are median ± SEM.
Should ATL Be Treated during Pregnancy?
Studies on different maternal infections have shown that mother and offspring can have distinct susceptibilities to infection in each stage of reproduction, from conception and gestation to parturition and the neonatal period. With regard to infections with protozoans, maternal malaria has been associated with fetal infection, preterm delivery, and growth restriction as well as maternal per partum death due to hemorrhagic complications [3]. The impact of the time of gestation on the consequences of infection was shown in toxoplasmosis: severe congenital toxoplasmosis was associated with maternal infection starting in the second trimester of pregnancy, and infections in the first trimester were associated with fetal loss due to severe damage to the embryo [11]. To our knowledge, there are no publications addressing these issues in cutaneous leishmaniasis (CL) patients. Untreated visceral leishmaniasis (VL) during pregnancy puts maternal life at risk and may result in fetal loss or in congenital VL [12], [13], and therefore, treatment of VL during pregnancy is compulsory. However, treatment of pregnant ATL patients is a debated issue [12], [14], [15] since there is no description of congenital infection, and many antileishmanial drugs, such as pentavalent antimony or miltefosine, are teratogenic [15]–[18]. Consequently, alternative therapies should be evaluated in order to warrant safety and efficacy in this group of patients. Guimarães et al [19] showed that 40% of patients with atypical manifestation of ATL were pregnant women and suggested that Amphotericin B should be considered as the drug of choice for all patients diagnosed with atypical ATL. Intralesional treatment with meglumine antimoniate was successful in over 83% of patients treated who had contraindication to systemic therapy [20], but there is a lack of evidence demonstrating safety in pregnant women. As spontaneous healing has been reported to occur after delivery [21], several groups avoid the use of specific treatment and follow the patients by using local heating and/or antibiotic ointments to control lesion development and secondary infections. More work is required to optimize the management of ATL during pregnancy.
Is the Occurrence of Metastases Possible?
The mechanism of metastasis in ATL is not fully understood. In Brazil, 3–5% of patients with LCL caused by L. braziliensis can develop mucosal lesions. Some of these patients did not have treatment during the primary infection, but metastasis can also occur after appropriate treatment [22]. We have followed up with our two pregnant ATL patients for 3–4 years, and they did not relapse or show any signs of mucosal lesions.
Exacerbation of cutaneous lesions in pregnant women due to infection with new- and old-world Leishmania spp has been reported; however, the mechanisms accounting for exacerbation of CL have not been clarified [4], [16], [19], [23]. Our results show transient modulation of maternal immune responses during pregnancy as indicated by exacerbated cutaneous lesions, increased parasite burdens, and decreased levels of IFN-γ and NOS2. Of note, both pregnant ATL patients had a restored Th1 response postpartum, associated with healing of the lesions. CL represents the majority of leishmaniasis cases worldwide, and in Brazil, 36% of the infected individuals are women of child-bearing age [22]. Despite the fact that our study was conducted in an endemic area, during an observation period of 4 years, only three pregnant women presented to our clinic with CL, and one of them had an abortion unrelated to leishmaniasis.
The impact of pathogens on human reproduction could be mitigated or exacerbated depending on the time of infection during pregnancy, the maternal immune response, nutritional status, and co-morbidities as described in toxoplasmosis [3]. The number of pregnant women infected with Leishmania parasites is generally low, and no information about the frequency of fetal loss in ATL patients is currently available.
At present, it is unclear whether the scarcity of reports on leishmaniasis in pregnancy is due to the use of contraceptives during the antimonial treatment, to increased embryo resorption or fetal abortion, to exclusion of pregnant women in many study designs, or to insufficient data on epidemiology of pregnant women suffering from leishmaniasis, a complex of diseases belonging to the most neglected tropical diseases.
Key Learning Points
- Pregnancy is accompanied by transient changes of maternal immunity, exemplified by decreased Th1- and increased Th2-type responses. The changes in innate and adaptive maternal immune responses during pregnancy are tightly linked to gestation and normalize postpartum.
- In patients with leishmaniasis, these transient changes in the maternal immune system enhance susceptibility to infection with Leishmania parasites and result in aggravated disease during pregnancy.
- Several drugs used to treat leishmaniasis are teratogenic. But if treatment is necessary, literature points to Amphotericin B as the drug of choice.
- Treatment of visceral leishmaniasis during pregnancy is compulsory, since vertical transmission has been demonstrated.
- As vertical transmission has not been described in cutaneous/mucosal leishmaniasis, patients with ATL may not be treated if the lesions are contained but should be frequently monitored during the course of pregnancy and postpartum.
Supporting Information
Table S1.
Clinical data of ATL patients before specific treatment.
Table S2.
Comparison of the in situ inflammatory response in pregnant and nonpregnant ATL patients.
We thank Drs. B. Askonas, J. Langhorne, and C. Bangham for critical reading of the manuscript; Simone Mendes (technical assistance), Vigileish (diagnosis), Heloisa Diniz and Rodrigo Mexas (final artwork), and Thomas Cloke (arginase assay); and the PDTIS-FIOCRUZ for use of its facilities.
- 1. Saito S, Nakashima A, Shima T, Ito M (2010) Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 63: 601–10.
- 2. Straub RH, Buttgereit F, Cutolo M (2005) Benefit of pregnancy in inflammatory arthritis. Ann Rheum Dis 64: 801–3.
- 3. Baecher-Lind LE, Miller WC, Wilcox AJ (2010) Infectious disease and reproductive health: a review. Obstet Gynecol Surv 65: 53–65.
- 4. Krishnan L, Guilbert LJ, Russell AS, Wegmann TG, Mosmann TR, et al. (1996) Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines. J Immunol 156: 644–52.
- 5. Arinola OG, Louis J, Tacchini-Cottier F, Aseffa A, Salimonu LS (2004) Interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in pregnant C57BL/6 mice infected with L. major at different gestational periods. West Afr J Med 23: 202–7.
- 6. Krishnan L, Guilbert LJ, Wegmann TG, Belosevic M, Mosmann TR (1996) T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells. J Immunol 156: 653–62.
- 7. Osorio Y, Bonilla DL, Peniche AG, Melby PC, Travi BL (2008) Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. J Leukoc Biol 83: 1413–22.
- 8. Morgado FN, Schubach A, Rosalino CMV, Quintella LP, Santos G, et al. (2008) Is the in situ inflammatory reaction an important tool to understand the cellular immune response in American tegumentary leishmaniasis? Br J Dermatol 158: 50–8.
- 9. Kropf P, Baud D, Marshall SE, Munder M, Mosley A, et al. (2007) Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol 37: 935–45.
- 10. Müller I, Munder M, Kropf P, Hänsch GM (2009) Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms? Trends Immunol 30: 522–30.
- 11. Montoya JG, Remington JS (2008) Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 47: 554–66.
- 12. Figueiró-Filho EA, Duarte G, El-Beitune P, Quintana SM, Maia TL (2004) Visceral leishmaniasis (kala-azar) and pregnancy. Infect Dis Obstet Gynecol 12: 31–40.
- 13. Pagliano P, Carannante N, Rossi M, Gramiccia M, Gradoni L, et al. (2005) Visceral leishmaniasis in pregnancy: a case series and a systematic review of the literature. J Antimicrob Chemother 55: 229–33.
- 14. Figueiró-Filho EA, El Beitune P, Queiroz GT, Somensi RS, Morais NO, et al. (2008) Visceral leishmaniasis and pregnancy: analysis of cases reported in a central-western region of Brazil. Arch Gynecol Obstet 278: 13–6.
- 15. Mueller M, Balasegaram M, Koummuki Y, Ritmeijer K, Santana MR, et al. (2006) A comparison of liposomal amphotericin B with sodium stibogluconate for the treatment of visceral leishmaniasis in pregnancy in Sudan. J Antimicrob Chemother 58: 811–5.
- 16. Morgan DJ, Guimaraes LH, Machado PRL, D'Oliveira A Jr, Almeida RP, et al. (2007) Cutaneous leishmaniasis during pregnancy: exuberant lesions and potential fetal complications. Clin Infect Dis 45: 478–82.
- 17. Miah MT, Ayaz FM, Maniruzzaman M, Ahasan MN, Bari S, et al. (2010) Kala azar in Pregnancy. Mymensingh Med J 19: 529–32.
- 18. Adam GK, Abdulla MA, Ahmed AA, Adam I (2009) Maternal and perinatal outcomes of visceral leishmaniasis (kala-azar) treated with sodium stibogluconate in eastern Sudan. Int J Gynaecol Obstet 107: 208–10.
- 19. Guimarães LH, Machado PRL, Lago EL, Morgan DJ, Schriefer A, et al. (2009) Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil. Trans R Soc Trop Med Hyg 103: 712–5.
- 20. Vasconcellos E de CFE, Pimentel MIF, Schubach A de O, de Oliveira R de VC, Azeredo-Coutinho RB, Silva F da C, et al. (2012) Intralesional meglumine antimoniate for treatment of cutaneous leishmaniasis patients with contraindication to systemic therapy from Rio de Janeiro (2000 to 2006). Am J Trop Med Hyg 87: 257–60.
- 21. Costa JM, Vale KC, França F, Saldanha AC, da Silva JO, et al. (1990) [Spontaneous healing of leishmaniasis caused by Leishmania viannia braziliensis in cutaneous lesions]. Rev Soc Bras Med Trop 23: 205–8.
- 22.
Ministério da Saúde (2010) Manual de vigilance da leishmaniose tegumentar americana. Brazil: Brazilian Ministry of Health.
- 23. Valesky EM, Thaçi D, Meissner M, Beier C, Wolter M, et al. (2007) Cutaneous leishmaniasis: clinical report of two cases and review of the recent literature. J Dtsch Dermatol Ges 5: 770–2.
- 24. Morgado FN, Schubach A, Vasconcellos E, Azeredo-Coutinho RB, Valete-Rosalino CM, et al. (2010) Signs of an in situ inflammatory reaction in scars of human American tegumentary leishmaniasis. Parasite Immunol 32: 285–95.


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biogas substrate homogenization News
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Download Audio tone generator - free apk 13.3 free for Android smartphone
Posted by AndWaves, LLC in Music & Audio | March 17, 2012 | 1 Comments
Apk file size: 67.0 KB
AudioGenerator has a very simple interface composed of 5 thumbwheels and an ON/OFF switch. Simply dial in the frequency in Hertz (cycles per second) and press the ON/OFF switch to start or stop the tone. The tone is a pure sinusoid.
There are no advertisements.
When the tone is ON, the thumbwheels are grayed out and the user cannot change the frequency. The thumbwheels can be freely changed when the tone is OFF.
Any frequency up to 440 Hertz is permissible; the Pro version goes to 22,050 Hz. Volume is adjusted with the volume controls on the Android device.
The program is useful to musicians, engineers, dog trainers and people who just want to informally test their hearing.
This program was developed on an Evo 4G.
I am interested in receiving feedback or any recommendations for improvements to this application. Please contact me at [email protected] with any questions or recommendations that you may have.
For information about this or other AndWaves products, see www.andwaves.com
Whats new
Ver 13 fixes bug that caused Ver 12 not to upgrade properly.
Ver 12 fixes problem with tone becoming inaccurate after long period of time.
Ver 11.3 fixes illegal state exception.
Fixed annoying program close when user dismisses OptionsMenu items.
Free version released Dec 8, 2011.
AndWaves, LLC part of our Music & Audio and have average installs from 5000 to 10000. Last Update March 17, 2012. Google play rating is 58.75. Current verison is 13.3. Actual size 67.0 KB.
Similar applications
FrequenSee - Spectrum Analyzer2276 Comments
1 Comments
A Google User
Very simple to use.


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" Manufacturer: Vivid Imaginations / Type: Animal Toys "
Two of my daughters love ponies and after being out with my friend one day they come back with a tiny little pocket penny which I have also done a review on. When I went to buy them these tiny little ponies I spotted these at the same time so I have decided to do a review on them also.
****The Product****
As you an see there are 5 different mummy horses alongside there babies. They are made out of plastic and have hair attached to them for their mane and tail. These plastic ponies both mummy and baby do not make any noise or do anything.
Although these do sound boring lets face it if children like them then why not a? I think my kids enjoy them as they can play mummies and babies. It is quite funny actually you should hear the convocations that they make up with they are roll playing. It is funny bless their little hearts.
It has the Lion mark on it but for those of you that don't know, Lion Mark is a symbol of Toy Safety. All our toys are tested for compliance with exactly the same approved safety standard.
****Where From And How Much?****
Just a little bit more information about the product that you will probably already know is that that there are different ways that you can order the product. You can phone the store to either reserve and pick up or get them to deliver it but it is an 0845 number that will cost you a pretty penny or you can visit:
which lets you reserve to pick up and tells you what store has got what items that you are wanting in stock or you can also use the website to get them do deliver which I feel is better as this save you money on a telephone call. But please note that there is a delivery charge of £5.80 so bare that in mind if you do wish you get it delivered.
I f I had of bought this on its own I would of paid £6.99 for them which is just far too much for tiny little ponies that don't do anything to be honest. Luckily you can buy it and another (selected) item from ARGOS for 2 for £15 so that works out at £7.50 which I think is reasonable enough for them.
****Additional Information****
If you bought this product and for what every reason you are not happy with it. I had enclosed the direct page below with all the relevant information that you will need take the product back. You can find this at:
A fellow reviewer informed me that lots of cash back sites pay out on Argos orders so you could get it even cheaper! So if you are a member of any of these sites then you will find this bit of information useful and for those that don't maybe think about joining one to save some pennies.
****My Overall Opinion****
I think that if your children are like mine, kind, caring, and have an interest in horses then I would recommend that you buy a pack. There is also another set that you an buy which I will be reviewing some time in the new future. They are called I love my pony and foal pack which is available to search on the ARGOS website which is listed as above and is also in the 2 for £15 section.
Considering everything that I have listed as above I would rate this product a 10 out of 10.
Thank you for taking the time to read my review I hope that it is of some use to you. Thanks again for reading it is very much appreciated.


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Invite the perfect blend of elegance and convenience into your life at Altera Riverside. Our beautiful community offers brand new renovated one and two bedroom apartment homes. The renovations have been thoughtfully designed with enough amenities to meet the needs of any lifestyle. Stunning interiors with high ceilings fill your spacious apartment with natural light and a fully-equipped gourmet kitchen with upgraded appliances which makes dining an absolute delight. When you step outside your front door, you walk into your community filled to the brim with fun and relaxation. Whether you're lounging beside our uniquely designed resort style pools with complimentary Wi-Fi, relaxing in the shade of our poolside cabanas, or enjoying a workout or participating in a friendly game of tennis on our lit courts, there's no end to the satisfaction you'll experience each and every day at Altera Riverside. Our picturesque neighborhood must be seen to be believed. The Lawrenceville Market Shopping
Lease terms are variable. Please inquire with property staff.
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Place used to be alright. Recently it has been all down. The place is just dirty. Go walk in breeze way and yo Read Moreu will quickly understand what I mean. Not a good value for what you pay and the office staff seem to think this is the best property around, not the case. I will not be renewing my lease!
February 11, 2014
The staff are friendly and always very quick to respond to any questions that I have. I have only had 2 very Read Moreminor maintenance issue arise since I moved in and they have been taken care of immediately. I feel safe in my building and have never had an issues with any of my neighbors. I've had an overall wonderful experience!
January 17, 2014
Used to be good management and good tenants. Buildings are dirty, Pet leash are everywhere despite designated Read Morearea for that. Several complaints made no improvements. No security. Vehicles get vandalized. Garbage system not robust several times non operational and prompt alternative is not planned. High maint
January 15, 2014
Overall it's a great place to live we just have people that don't go by the rules. I love staying here overall Read More.
January 14, 2014
I have lived at Century Riverside for 8 years. I love the location but have to say that the property is starti Read Moreng to show it's age. Other complexes have newer kitchen appliances and cabinets. The price for a one bedroom is quite expensive for the area.
January 14, 2014
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|BABY BIBS: Approximately 11"W x 14"L. A: Bias Binding. B: Contrast collar.
|FABRICS: Cotton and Cotton Blends, Calico, Novelty Cotton and Gingham.
|Unsuitable for obvious diagonals.
|*with nap. **without nap.
|NOTIONS: 5/8" x 1" piece of VELCRO® Fastener Tape.
|A: 13/8 yds. each of 1" Wide Bias Tape and Jumbo Rickrack.
|B: Two 2" Ribbon Bows and 2yds. of 1/2" Lace Ruffling.
|Combinations: A: (ONE SIZE)
Fabric widths given in inches.
|A,B - 45*/** - 1/2 yd.
|CONTRAST B - 14" x 8" Fabric
Fabric widths given in centimeters.
|A,B - 45*/** - 0.5m
|CONTRAST B - 20cm x 20cm Fabric
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Both the UNAA National Office and UNAA Divisions offer a series of internship opportunities throughout the year. For Division internship opportunities please view the pages of your local Division or contact them directly.
Current Opportunities
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Mid 2017 Internship
We offer this competitive internship opportunity to give the selected intern the opportunity to work in a role directly reporting to the UNAA National Executive Director, while growing their skills and gaining extensive experience with one of the Australia's leading international affairs NGOs.
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David Knipe announced as Scotland U18 Boys' Head Coach
20 March 2017
Scottish Hockey is delighted to announce the appointment of David Knipe as Head Coach of Scotland's U18 Boys' squad.
David is the Head Coach of the Grange men's first team squad, who are currently sitting in second place in men's National League 1 and pushing reigning champions Bromac Kelburne all the way for the title. David will now also take on the responsibility of developing the next generation of male Scotland hockey stars.
The Scotland U18 boy's finished third at EuroHockey Championship II in Glasgow last year - and will aim to be equally competitive next time round, but with the emphasis on providing the appropriate support and opportunities for our aspiring young athletes to showcase their talents and grow their skills on the international stage.
Andy Tennant, Head of Performance for Scottish Hockey, said "We are delighted to have secured David's services to help accelerate the development of our best young male athletes, with the ultimate goal of delivering more high quality hockey athletes into the under 21 and senior men's programmes in future.
"David is an excellent example of a new breed of ambitious young coaches who will help us drive towards our ambition of delivering successful Scotland teams and podium athletes."
David Knipe said, "It's a real honour and exciting challenge. I am looking forward to meeting and working with the squad and to helping play a part in their development as both people and players."
The under 18 programme kicks off at Easter with a trip to Cardiff to play internationals against Wales and Switzerland.


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RepairPal is your advocate for car care advice and guidance
Q: what causes the serpentine belt to break if not old?
on 1997 Jeep Grand Cherokee
Driving to work & serpentine belt broke. My husband thinks the water pump may not be working. Is there anything else that may have caused a fairly new belt to break?
| |
Several things can cause a belt that is not old to fail. If any components like power steering pump, A/Compressor, alternator, harmonic balancer (not just idler or tensioner) has a pulley that has a loose bearing or bent will cause wobble, has a bearing or internals seizing, has damage to a pulley that is damaging a belt, has a pulley misaligned or a defective belt. If you need your vehicle checked out and repaired please call Andrew of Kris 456-0722 at CarMasters, thanks, Jim
Suspect either your idler pulley or belt tensioner pulley. Take belt off and spin pulleys- maybe bearings on either binding up and throwing belt off track and shredding.
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