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A complex microdeletion 17q12 phenotype in a patient with recurrent
Microdeletions on chromosome 17q12 cause of diverse spectrum of disorders and have only recently been identified as a rare cause of Mayer-Rokitansky-Kuester-Hauser-Syndrome (MRKH), which is characterized by uterus aplasia ± partial/complete vaginal aplasia in females with a regular karyotype. For the first time we report about a patient with a 17q12 microdeletion who is affected by MRKH in combination with a vascular and soft tissue disorder. Repeatedly she suffered from kidney transplant failure caused by consuming membranous nephropathy.
Case presentation
A 38-year-old female patient had been diagnosed with right kidney aplasia, left kidney dysplasia and significantly impaired renal function during infancy. Aged 16 she had to start hemodialysis. Three years later she received her first kidney transplant. Only then she was diagnosed with MRKH. The kidney transplant was lost due to consuming nephrotic syndrome caused by
Deletions of
Microdeletions on chromosome 17q12 encompassing the hepatocyte nuclear factor 1β (
Case presentation
A now 38-year-old female patient was born as the third of four daughters of healthy parents. Her oldest sister remains healthy, while her second oldest sister suffers from idiopathic focal epilepsy and her youngest sister from Prader-Willi-Syndrome caused by a maternal parental disomy on chromosome 15. Following a regular pregnancy our patient first presented with a pyelonephritis at the age of four months. Right kidney aplasia and a significantly impaired renal function (serum creatinine 1.9 mg/dl, urea 83 mg/dl) were then noted, already indicating dysplasia of the left kidney. Her female external genitalia showed no anomalies and cystoscopy documented the presence of bilateral ureters. Over the following years chronic renal failure progressed as recurrent urinary tract infections occurred. Finally, she was referred to a pediatric nephrology unit at the age of 10 years and started hemodialysis six years later with a serum creatinine of 6 mg/dl. Aged 19 she received her first kidney transplant without any complications. As primary amenorrhea had persisted while pubertal development was commensurate with age, a diagnostic laparoscopy was undertaken and revealed a rudimentary uterus and regular ovaries. On the basis of a normal 46/XX karyotype the diagnosis of atypical Mayer-Rokitansky-Kuester-Hauser-Syndrome (i.e. MRKH Type II) was made. Aged 28 her first kidney transplant was lost due to consuming nephrotic syndrome caused by biopsy-proven
Figure 1
Percutaneous kidney biopsy four weeks after the second kidney transplantation revealed de-novo MN and moderate tubulo-interstitial changes (a) and granular pseudolinear deposition of immunoglobulin G (IgG) along the epithelial surface of the glomerular basement membrane (GBM) (b).
Percutaneous kidney biopsy four weeks after the second kidney transplantation revealed de-novo MN and moderate tubulo-interstitial changes (a) and granular pseudolinear deposition of immunoglobulin G (IgG) along the epithelial surface of the glomerular basement membrane (GBM)(b). C3c-deposits along the GBM of the patient were present (c). In reverse, incubation of human kidney samples with serum from the patient showed immunofluorescent staining of the GBM, documenting the presence of anti-human-GBM alloantibodies in the patient (d).
In addition to her urogenital anomalies our patient is affected by a hyperelasticity syndrome with congenital joint laxity, kyphoscoliosis, and bilateral hip dysplasia. She shows persistent hypermobility of both elbows and knees and is easily able to place her feet behind her head, all of which are very unusual findings in a longstanding dialysis patient (Figure
Figure 2
Vascular and soft tissue disorder of the patient with hypermobility of both elbows (a) and hips (b).
Vascular and soft tissue disorder of the patient with hypermobility of both elbows (a) and hips (b). Hyperdynamic arterio-venous fistulas on both arms (c) led to tricuspid valve insufficiency and required ligation, which resulted in a rapid decline of the significantly raised brain natriuretic peptide (BNP) (d).
In summary, this clinical picture resembles a mixture between a hypermobile (EDS3) and a vascular (EDS4) form of Ehlers-Danlos-Syndrome (EDS). Mutation analysis of the collagen type 3 alpha 1 gene (
We therefore performed an array-based comparative genomic hybridisation (CGH) and detected a heterozygous 1.43 Mb deletion on chromosome 17q12 (Figure
Figure 3
The heterozygous 1.43 Mb deletion arr 17q12(34.817.222-36.249.059)x1
The heterozygous 1.43 Mb deletion arr 17q12(34.817.222-36.249.059)x1 (ISCN 2009, GRCh37/hg19) containing the sixteen RefSeq genes
Mayer-Rokitansky-Kuester-Hauser (MRKH) is a quite common inherited condition (1:4.000-5.000) characterized by uterus aplasia ± partial/complete vaginal aplasia in females with a regular karyotype XX/46 and physiological ovarial function
Following kidney transplantation our patient repeatedly developed MN, a major cause of nephrotic syndrome in adults. We excluded secondary causes of MN and detected no
Above all, our case illustrates how recent molecular findings in inborn orphan disease may permit the diagnosis for complex phenotypes in adult patients - a circumstance which was truly appreciated by our patient 38 years after her first clinical presentation.
Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Series Editor of this journal.
CNV, Copy number variants; COL3A1, Collagen type III, alpha 1; EDS, Ehlers-danlos-syndrome; FBN1, Fibrillin 1 gene; GBM, Glomerular basement membrane; HNF1β, Hepatocyte nuclear factor-1β gene; LHX1, Homeobox transcription factor 1 gene; MN, Membranous nephropathy; MRKH, Mayer-rokitansky-kuester-hauser-syndrome; NODAT, New onset diabetes mellitus after transplantation; NT-pro BNP, N-terminal pro brain natriuretic peptide; PLA2R, Phospholipase A2 receptor.
Competing interest
The author(s) declare that they have no competing interest.
Authors' contributions
BH wrote and revised the manuscript, coordinated the studies for this manuscript. JJ was the treating physician and substantially supported the writting of this manuscript. KA carried out the nephropathologic studies. HB, SN, CB carried out the molecular genetic studies. KH, MGS, WR, KUE supported this work by providing critique of succesive drafts of the manuscript. All authors read and approved the final manuscript.
We would like to thank our patient and her family for participating in this study. Also, we would like to thank the following colleagues: Gérard Lambeau, Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia Antipolis et Centre National de la Recherche Scientifique Valbonne, France for PLA2R antibody screening. Michaela Arend, Department of Nephrology and Hypertension, University of Erlangen-Nuremberg for technical assistance. Maike Büttner and Christoph Daniel, Department of Nephropathology, Thomas Winkler and Ute Wellmann, Department of Genetics, University of Erlangen-Nuremberg for tissue sample preparation. Sybille Thoma-Uszynski, Department of Dermatology, University of Erlangen-Nuremberg for clinical assessment of the vascular and soft tissue disorder. Ingrid Hauser, Electron Microscopy Unit, Department of Dermatology, University of Heidelberg, for reference assessment of the skin biopsy.
Anomalies of the TCF2 gene are the main cause of fetal bilateral hyperechogenic kidneys
HNF1B and PAX2 mutations are a common cause of renal hypodysplasia in the CKiD cohort
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy
Recurrent microdeletion at 17q12 as a cause of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome: two case reports
Genomic imbalances associated with mullerian aplasia
Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-Kuster-Hauser syndrome
HNF1B-related diabetes triggered by renal transplantation
Recurrent reciprocal genomic rearrangements of 17q12 are associated with renal disease, diabetes, and epilepsy
Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia
Clinical spectrum associated with recurrent genomic rearrangements in chromosome 17q12
The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
Lim 1 is required for nephric duct extension and ureteric bud morphogenesis
Pre-publication history
The pre-publication history for this paper can be accessed here:


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The $10 Spa Spot
Pricing and product mix drive supermarket spa sections.
Supermarket consumers think cheap and basic when it comes to HBC spa merchandise — even those who frequent both grocery and high-end specialty channels. This has caused many retailers to struggle with developing the right product mix.
When shopping The Body Shop or Bath & Body Works, consumers rank self-indulgence above price. In supermarkets, they often have a set budget. Hence, when a supermarket tries selling scented massage oils or other specialty categories featured by chains like The Body Shop or Bath & Body Works, it winds up with slow turns and dusty bottles.
"Shoppers have different expectations for different channels," says Dan Graham, vice president at San Juan Capistrano, Calif.-based retail consultancy Dechert-Hampe Co. "In supermarkets, the focus is on impulse-driven basics that are used every day."
Margins on spa merchandise are attractive. But outside of a few high-end grocery chains, prices cannot exceed $10 to $15. "Depending on the category, once you go over $9.99, you limit sales," says Deirdre Williams, director of skincare for Stamford, Conn.-based Lornamead, maker of Yardley scented soaps. "While a specialty consumer may spend more, she is earmarking how much she plans to spend during a grocery trip."
According to Nielsen Company data, supermarket sales of specialty soap alone grew by 3.8 percent to $319 million for the 52 weeks ended March 21, 2009. Sales of grooming sponges, another basic, increased by 5.3 percent to $25 million.
Other common bath items also perform well. One supermarket buyer says bubble bath is one of his highest volume subsegments.
Maria Brous, director of media and community relations for Florida-based Publix, cites high volumes in body washes and bath salts. Publix, along with H-E-B and Wegmans, is considered one of the more successful supermarket spa retailers.
Quality, appeal and pricing on basics should be a notch above that of in-line merchandise. One buyer pegs margins in the 40-point range — 5 percent to 10 percent higher than general HBC.
Back to Nature
Spa products' added cachet can be a special scent or ingredient. In candles, another important category, attributes can move pricing from $8 (in-line) to $12 (spa display). But expectations must be realistic. "I'm not saying we can go to $30," says Bryan Olson, VP of marketing and sales for Soy Basics. The Minneapolis-based company has offered a food, drug and mass line for four years. Candles retail for $3.49 to $14.
Nature-inspired scents and ingredients, in particular, work well in certain stores. The anonymous supermarket buyer, for one, divides spa products into three subcategories. His first tier contains "such items" as Calgon bath beads and bubble bath. Tier two involves a wider selection of higher-priced basics and specialty products. The third, most upscale segment, emphasizes natural HBC.
"This involves a very different item selection and a largely different supplier list," he adds. "The key is not to go outside the comfort level of the given retailer. You have to go back to demographics."
Publix also micromarkets nature-inspired spa products. Its three Publix GreenWise Markets focus entirely on natural and organic merchandise. The spa section, located in the center of these prototypes, uses special lighting and shelving. Brous says Publix's other stores are "more traditional" in their spa approach.
In the Northeast, A&P is taking a natural approach in some of its remodeled stores. In a New Jersey location, an 8-foot spa section includes Ecco Bella's herbal body lotion, Avalon Organics' Bath & Shower Gel, and body lotions from Nature's Gate and Earth's Best. Ingredients include rosemary, peppermint, lavender, sea moss and mango.
On the manufacturers' end, bar soaps in Lornamead's Yardley brand contain 98 percent plant-derived ingredients in a vegetable base. Lornamead also has a botanical line. Its top scent/formulation is English Lavender, followed by Oatmeal and Almond. Prices range from $1.49 (botanical soap) to $7 for Lemon Verbena, a new soap inspired by a French boutique.
Soy Basics taps into consumers' growing awareness of soy. Its tapers burn cooler and longer than petroleum-based candles, and scents last longer. SuperValu, Jewel and Harris Teeter are among those offering Soy Basics.
In skin cream, derma e features an antioxidant, five-SKU assortment of Fruit Smoothee moisturizers, facial cleansers and other products. Trendy ingredients include vitamin E, Ester-C, acai berry, pomegranate and cranberry.
But trendy natural ingredients have a downside in that they can limit a product's lifecycle. "Aloe can quickly become yesterday's flavor," says Dechert-Hampe's Graham.
No Potholders
Mall specialty retailers frequently merchandise spa items around themes like scent, color, season or subsegment (feet, suncare, juvenile, etc). Their higher margin structure also lets them augment consumables with items like back scratchers and massagers.
While supermarkets want variety, they have constraints. Hence, some of these strategies have been disastrous. According to Nielsen, supermarket sales of body massagers declined 22.3 percent to $3 million during the 52 weeks ending March 21, 2009.
"'Appliances' like massage rollers, back brushes and other nonconsumables are a push in grocery," says Don Stuart, president and CEO of Darien, Conn.-based Cannondale Associates. "Deep segmentation can also be an issue. While specialty stores may do well with a foot-care subsection, supermarkets must cater to the masses."
Some supermarkets try to spice up basics with irrelevant merchandise. Others look to hit certain price points with private label. The New Jersey A&P mixes picture frames with bath items. Another retailer offers potholders in its spa section.
"Specialty bath can easily become a catch-all," says Lornamead's Williams. "Retailers sometimes say, 'Let's put it there for lack of a better place.'" Most items on A&P's free-standing aisle fixture, though, hit appropriate prices of $7 to $10.
Private label products made from quality ingredients can work; cheap knockoffs with a chemical after-smell or poor consistency do not.
"There's a difference between bargain bin and store brand," says Jeff Rehling, principal at Parsippany, N.J.-based Edgewood Consulting Group. "The question is which brands offer the uniqueness, equity and quality shoppers of a particular retailer are looking for in this category."
Consumers are also concerned about lead and other unhealthy ingredients sometimes found in inexpensive China-made HBC products. "Given consumers' growing desire to monitor ingredients, retailers want to ensure that suppliers are thoroughly tested," says Lornamead's Williams. "If it's made in China and has no brand name, people hesitate. They also want a consistent scent and performance."
Publix and Food Lion sell private label in their children's spa areas. And H-E-B is making its mark with exclusive brands. But both Publix and H-E-B have well-established HBC reputations.
"H-E-B has a whole section that is a destination for beauty," says Taya Tomasello, senior beauty analyst at Chicago-based Mintel. "It is a store-within-a-store. In other grocery stores, it's just a section."
Some retailers create temporary spa sections. Schnucks, a regional St. Louis chain, devotes an aisle to "special" merchandise, says Tomasello. While some offerings are a bit odd — like televisions — consumers expect surprises.
Most likely, spa items are the fruits of small-lot, opportunistic buys. While spa products have worked well in this section, Schnucks services a small store base. The strategy would be harder for a large chain to implement.
Spa's Future
Despite some success, experts question the long-term potential of supermarket spa sections. For starters, there is no real category management template. "Few grocery retailers seem to understand the role and strategy these types of products play with their shoppers," says Edgewood's Rehling. "From one retailer to the next, it's a very fragmented and inconsistently merchandised category."
Many sections involve niche suppliers. Products from CPG giants are too generic; those from specialty vendors are too expensive. But niche vendors' items can have low brand awareness and create SKU-management headaches.
"I don't think spa will ever be the biggest part of HBC, particularly in grocery," says Rehling. "The whole area is very experimental. It probably will never be a trip-driver. With a targeted strategy, it does have the potential to be a profitable, complementary category that can boost transactions."

subset: commoncrawl


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** Selected for the San Diego Surf Film Festival and the Del Mar Cinema Series.
** Selected for the San Diego Surf Film Festival and the Del Mar Cinema Series.
From ReadWriteWeb:
The article explains this difference very well:
An interesting read – ReadWriteWeb
I have something terribly gross for you. Something so detestable you certainly won't think of it like reusing a toothbrush. A bathroom act that asks you to wash and reuse. This despicable act is to reuse your floss.
Floss is different from a toothbrush or comb because it goes in your mouth. It is now infected with disease and should be immediately be thrown out. Do not even think of rinsing it off and using again. Definitely do not be place it next to the toothbrush that you will rinse off and use again.
Remember, the Earth has infinite resources and we should not worry about little things like floss. There is enough landfill space for billions of strings. We have enough room for the daily floss of 8 billion people and the 2.9 trillion pieces they could use each year.
So the next time you floss avoid reusing it. Make sure to throw it away and buy more at the store. It's cheap and you can always grab some money off your money tree.
From the USGS Water Science School:
Let's say your house sits on a one-half acre lot. And let's say you get a storm that drops 1 inch of rain. You've just received 13,577 gallons of water on your yard. A big bath holds about 40 gallons of water, so if you could save that inch of water you could take a daily bath for 339 days!
A great reason to get a rain barrel and collect all that water. Place it underneath your gutters and you'll have an endless supply of water for your garden. Be a water warrior!
It's not everyday that ESPN covers bodysurfing, here is Keith Malloy:
When I was a kid, my friends and I would go down to the beach and kind of camp all day. When you're a kid the experience of being at the beach is just as good as actually surfing. We would leave our boards on the beach, go out and just get slammed, pull into the barrel and look at each other. You know, just that typical grom stuff.
The joy of bodysurfing and I love it, but then they took it to another level on the dangerous waves of Tahiti. View the behind-the-scenes photos of their trip from the movie Come Hell or High Water.
Peter Jackson's behind-the-scenes extras are legendary and this new iPhone, iPad app for The Hobbit should be fun:
View animated character portraits, travel through an interactive map of Middle-earth, watch Peter Jackson's production videos, and explore the stunning narrative imagery of "The Scroll" artwork to immerse yourself in the world of Hobbits, Dwarves, Elves, Orcs, deadly Wargs, giant Spiders and fearsome Dragons.
I'm excited to get my geek on! Here is the link to download - http://bit.ly/HobbitMoviesApp
I propose a new way to think about the Great Recession in America. Instead of the middle class is dying, how about the dirty middle class is dying. The way of life where overconsumption and gas guzzling is more American than recycling or biking. If our energy supply can be both dirty and clean, why not our lifestyles?
Consider the average family spends 20% of their budget on transportation. That's 10 weeks/year just to pay for car and gas. But what about the big gas guzzlers, the kind that cost $80 to fill-up. No one wants to pay $100 for gas but that is where we are headed. And yet there are plenty of them on the street. As those gas prices tick up I think they will slowly disappear and be replaced by bikes and EV's.
Food is another area in slow decline. You might've heard that 69% of Americans are overweight or obese. That's a lot of extra money spent on food, especially when times are tight. A new report shows our consumption of candy and processed foods has doubled in the last 30 years. What if a family were to save money by committing to healthy portion sizes, cutting out processed foods, and putting that savings towards college.
Last, think about the basic rule of disposable goods. They only work once and you have to buy more every week. Not only is this horrible for the environment but it costs a lot of money. Families could go broke following the jingles in commercials. And those who are pushing hard on – reduce, reuse, recycle – are again finding themselves with extra money to spend on family vacations.
After all, isn't that what being in the middle class is about, family vacations? Being able to work, have fun, and save a little money for college or retirement. I thought so, but somehow that dream became owning an SUV, overeating, and buying something to throw out. But take solace in knowing that this dirty way of life is moving towards extinction. To be replaced by green families who ride bikes and have vegetable gardens.
It gives new meaning to the saying, there goes the neighborhood.
For 25 years volunteers have gathered together for Coastal Cleanup Day. The annual event takes place this year on the morning of September 15, 2012.
To volunteer in California visit the California Coastal Commission. For anywhere else visit International Coastal Cleanup.
You can also take a pledge to keep our waters trash free, and follow the event on Facebook and Twitter.
Science look to nature for innovation, via BBC News:
San Diego Zoo in California has opened a Centre for Bioinspiration, which aims to take ideas from nature to see if they can be applied to solve human issues.
The concept is known as biomimicry.
Examples of biomimicry, from Xconomy:
—Mirasol display technology…generates colors…by mimicking the interference of reflected light by microscopic scales on the iridescent surface of the morpho butterfly's wings.
—San Diego's Biomatrica has developed DNA and RNA preservation technology based on anhydrobiosis, a dehydration process that occurs in nature with brine shrimp and other organisms.
Fascinating stuff. More examples can be found at San Diego Zoo's – Biomimicry in Action.
// Image - Biomimicry in Action
It's hard to commit to using less water because it involves everything fine and delicate: cleaning our bodies, our food, and our clothes. We have a level of comfort with cleanliness and nobody wants to be smelly. The United States is particularly obsessed with this ("Cleanliness is next to Godliness"). We use nearly as much water as China and they have four times the population.
And water conservation is a worthwhile cause, from the EPA:
In the last five years, nearly every region of the country has experienced water shortages. At least 36 states are anticipating local, regional, or statewide water shortages by 2013, even under non-drought conditions.
Keep that in mind with these water conservation tips. Approach them with caution, do a little at a time, and find your comfort level. At times you may go too far and that is okay. Often I go too long without showering and am reminded, it's time.
Water use in the home covers four areas: kitchen, bathroom, laundry, and outdoors. Which I break down into two categories – turn-off the running water and change your habits. The first is such a common sense idea, but we frequently keep the water running without doing anything. When you brush your teeth for 2 minutes and use the running water for 5 seconds. Or, when you pause in the shower to lather and ignore the gushing stream behind you.
I daresay these are easy changes:
I know these are simple and common sense, but they are also habits. Repeated practice can save bucketfuls of water. Remember, the average American uses 100 gallons of water/day!
The second recommendation is for the water warriors. These require true determination, involving a substantial change:
I have tested these recommendations and found them very livable. It took a few weeks to learn each habit, but now I'm proud of my water use. I think I'm becoming a water warrior!
Maybe I'm ready for the big challenges.


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Wednesday, May 17th, 2017
Water conservation is a growing concern globally, and particularly for farmers in the United States, where decades of irrigating huge fields has depleted vital resources of fresh surface water and groundwater. To help alleviate this problem, a European Space Agency (ESA) spin-off that hopes to help preserve water supplies while guaranteeing crop irrigation is now
Tuesday, February 21st, 2017
The emerald golfing greens have seen better days. According to the U.S. National Golf Foundation, the number of players has steadily declined from over 30 million in 2005 (pre-recession) to 24.7 million today; 680 US and 158 Canadian courses have closed. "Golf course owners are working smarter to manage resources like water and labor more
Tuesday, January 24th, 2017
Hydrologists at the Colorado Basin River Forecast Center are providing streamflow forecasts for watersheds within the Colorado River Basin, which includes some of the most parched land in the United States. "The forecasts we get from the center provide crucial information for managing our water resources and reservoir facilities," said Dave Kanzer, a deputy chief
Monday, November 14th, 2016
Researchers from UT Dallas and other universities developed geospatial science methods to help the Egyptian government determine how to avoid flooding in a coastal mountain region. The government wants to develop the area for tourism, but flash flooding and associated hazards have hampered efforts, according to Dr. May Yuan, Ashbel Smith professor of GIS. "We
Monday, October 24th, 2016
A new study using NASA satellite data finds that tide gauges—the longest and highest-quality records of historical ocean water levels—may have underestimated the amount of global average sea-level rise that occurred during the 20th century. A research team led by Philip Thompson, associate director of the University of Hawaii Sea Level Center in the School
Thursday, June 30th, 2016
In the face of climate change impact and inevitable sea level rise, Cornell and Scenic Hudson scientists studying New York's Hudson River estuary have forecast new intertidal wetlands, comprising perhaps 33 percent more wetland area by the year 2100. "In other parts of the world, sea level rise has led to net losses of tidal
Thursday, June 30th, 2016
Dewberry has completed the National Hydrography Requirements and Benefits Study (HRBS) for the U.S. Geological Survey (USGS). The firm conducted the study—sponsored by USGS and the U.S. Department of Agriculture's Natural Resources Conservation Service—to establish a baseline understanding of national business uses, needs, and associated benefits for national hydrography data; and to inform the design
Monday, June 27th, 2016
Even with this winter's strong El Niño, the Sierra Nevada snowpack will likely take until 2019 to return to pre-drought levels, according to a new analysis led by UCLA hydrology researchers.
Tuesday, June 21st, 2016
An experimental tool to give farmers, government officials, environmental groups and other stakeholders an improved estimate of how much water is available in a specific watershed is scheduled to go on line this summer.
Friday, May 27th, 2016
Spring snowpack, relied on by ski resorts and water managers throughout the Western United States, may be more vulnerable to a warming climate in coming decades, according to a new University of Utah study. The study, accepted for publication in Geophysical Research Letters, models the year-to-year variability in precipitation and temperature in Utah's Wasatch Mountains


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In this time of transition for our industry, it's important to know why Envoy Mortgage is the Best Opportunity in the Mortgage Business. Our primary mission is to preserve the dream of homeownership. Naturally, our focus, as a result, is squarely on the future.
Envoy Mortgage is a full-service mortgage bank headquartered in Houston, Texas. We operate a network of retail branch locations across the United States, currently originating in 48 states. Our branches offer a full menu of home loan products and concentrate on building repeat referral sources for purchase business. Providing consistent, quality service to your builders and realtors is our bread and butter.
Envoy Mortgage will give you the leading edge in optimum efficiency and productivity. As an Envoy Mortgage affiliate, you will enjoy full corporate support from our regional offices. We have assembled the right tools, including mortgage marketing, accounting services, benefits and technology to make our loan officers and their teams successful.
We exceed the mortgage industry standards. Consider the Envoy Mortgage difference…
Envoy has been successful for over 15 years because of its people, systems and technology. We consider growth a natural result of doing business the right way, not an end in itself. At Envoy, you can expect to work with a time-honored team that understands our culture and your business.
Breakthrough services means increased productivity. With services such as Overnight Price Protection on purchase loans, we increase productivity so your consumers don't have to wait until Monday to lock in their rates! These are one of the many services that we offer to increase your pipeline – our expertise is growing your branch's production!
We have a strong commitment to delivering exemplary service in every business facet: technology, loan products and marketing. Our Hall of Fame includes: Top-Tech Savvy Lender Award for the past 7 years | 2010 Green Originator of the Year | eSignature and a paperless platform | Powerful CRM and retention program | Loan Originator Websites – These are just a few ways of how we are determined to commit to you and your business
When a branch or originator joins the Envoy family, we ensure that our new colleagues receive the training and support they need to become fully productive as quickly as possible. Originators and branch managers also enjoy access to Branch Support, a dedicated team that answers any/all questions, local processing and centralized closing/funding departments.
At Envoy Mortgage, we are always researching market trends and our goal is to stay ahead of the competition, which is essential for a successful mortgage company. We guarantee that we will fund an unlimited amount of mortgage loans so you can continue to conduct business to your maximum potential. It is a 100% guarantee. You can count on us.
We strongly believe that we exceed the industry standards in many areas, but especially in our commitment to quality. When your customers demand excellence, we will be there to help you deliver. Staying connected with your customers is vital in the mortgage business. We will help you streamline and help you organize systematically with fast underwriting, same-day closings and funding. Our knowledgeable and experienced support staff is always available to assist you with all of your needs.
At Envoy Mortgage, we understand the need for our home loan officers to have the right tools to succeed. We are always looking for opportunities to develop new technology as well as enhance our existing systems and procedures to make it easier for our loan officers to do their work and continue to provide accurate and efficient transactions for our customers.


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Johannesburg, Nov 7: After Tony Greig and Martin Crowe, England cricketer turned commentator, Robin Jackman has been diagnosed with cancer and is expected to undergo seven weeks of radiotherapy and two operations to remove malign tumours.
The cricketer turned commentator has been diagnosed with malign tumours in his vocal chords as he is expected to undergo operations to remove the same followed by radio therapy for seven weeks and rest for 4 weeks.
The 67-year-old who was diagnosed with cancer, became the third high profiel commentator to be affected within a month's time after Tony Grieg and Martin Crowe.
"It's not the prettiest, but I got it early and I'm confident I'll be fine," Jackman was quoted as saying in the South African media.
Jackman, who has been making his living off the microphone, has had two malignant tumours removed from his vocal chords already and this being the third time, the commentator has been advised seven weeks of radiotherapy.
With Geoffrey Boycott being a classic example among former players and commentators surviving cancer as he took proper medication and moreover early diagnosis helped Boycott recover from cancer. While Boycott's story has been inspiring to many, India's Yuvraj Singh who also battled a rare germ cell cancer at a young age is another example and truly inspirational.


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Niuer i s household name, especially in his home country of Taiwan, where everyone refers to him as the "Beauty King". The name "Niuer" has been voted #5 on the 2006 Taiwan yahoo top 10 shopping brand. surpassing some such as Sony, Apple, Tiffany & Co. and other well known international brands. In 2008-2010, the brand was favored by over a billion online users in China. For 3 consecutive years, it was given the award for " the most outstanding contribution to beauty" by SoGua, and it is the only beauty brand that has ever received an award for the "2009 Top 80 Most Celebrity Brands."
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It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the site.
This step is optional but will seriously boost your chances of getting interest from other Christian members on the site. Tell people about yourself, your pasttimes and upload a nice photograph of yourself.
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Located someone who you find interesting? Send a message to them or just a wink and see what they say. With a little luck you'll be on your way to true love.
It doesn't take long


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I'll admit that I'm a bulletin board person... a bulletin board fanatic maybe? I love adding new color and getting kids excited about something different. I use the Composer of the Month sets by Sara Bibee and change them out every month. I also change out my monthly "Moral Focus" bulletin board which features two new famous musicians every month and talks about how each musician exemplifies the moral value of the month. And then of course I have to change my monthly calendar set to show off the famous composers, musicians, producers, and musical artists who were born each month. That's a lot to change every 1st of the month, I know (but the kids get so excited about each one... I can't stop now!).
I wanted something fun and easy to fill up my "achievement" board in the hallway this December. This bulletin board space is front and center in our school and in an extremely busy hallway. I wanted to display something seasonal and fun and colorful that will get kids excited about music in December. I also didn't want to change out my blue background fabric (because that takes SO much more time than just changing content/posters on the front). So, I printed out and posted this new set called "Celebrate Caroling!" which tells the history of caroling, gives a little information about famous carols, and has cute little images of kids riding musical snowflakes! It took me a total of 30 minutes to print, laminate, cut out and post on the board. Check out the gallery below to see pictures. Definitely check out the switch from "Give Thanks for Music" (blue background) from November to "Celebrate Caroling!" (also blue background!) in December. EASIEST SWITCH IN THE WORLD! :D


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We were offered mint tea when we reached. We had a room on the ground floor and it was not noisy. The room was nice and cosy but it's a pity there is no heater - I must admit though that the room wasn't too cold so we were fine without heater. The bathroom is nice and bright and we appreciate that a lot. There is a tv as well but there is no English channel which was a pity again. The riad is very near to the Djemma El-Fna, only about 2mins walk at most. It was a pleasant walk.
The staff were nice and once we wanted to order mint tea as we were not well and they gave it to us for free. The staff were always smiling and that made us feel welcome. One huge thing we appreciate is that they were not pushy.We ate out daily and they didn't mind that. Breakfast was nice but unfortunately there was a cat hanging around at the terrace and I'm afraid of cats. They were very kind and allowed us to have it at the courtyard. The staff serving the breakfast was also very nice and obliging. They were always helpful and answered our questions when we need help. The room was cleaned everyday and fresh towels given.
They had a performance for new year and asked us to join but we were not well so we stayed in our room instead. We highly recommend Riad Hamdane - it felt very homely. On the last day, they even help us get a person with a cart to carry our luggage. I would definitely stay here again if I'm in Marrakech. We stayed 4 nights here and felt it was too short. We love Marrakech and Riad Hamdane.
- Official Description (provided by the hotel):
- Au coeur de la Medina, et dans le quartier le plus prise de la Medina de Marrakech (Sidi Boulokate) decouvrez un lieu calme, authentique et chaleureux. Facile acces a pied, notre riad chambre d'hotes est idealement situee dans la medina pour rejoindre rapidement les celebres sites touristiques de Marrakech : la celebre place Jamaa El Fna, la Koutoubia, les jardins de Majorelle et de la Menara, les palais Bahia et El Badi, la medersa Ben Youssef, le musee de Marrakech et les fameux souks de Marrakech. Vous tomberez sous le charme de notre maison d'hotes, qui par sa decoration et son mobilier, reflete l'art et l'artisanat traditionnel marocain. Le RIAD HAMDANE ET SPA a ete renove dans la pure tradition locale et offre confort et excellent rapport qualite/prix. La convivialite du RIAD HAMDANE ET SPA en fait l'endroit ideal pour vos vacances en famille ou entre amis. Des votre arrivee, vous serez chaleureusement accueillis par Notre staff, Ce dernier se fera un plaisir de rendre agreable votre sejour a Marrakech en vous faisant decouvrir sa culture, les traditions de son pays et la cuisine marocaine. Le riad dispose de 2 suites pour 2 et 4 personnes et 14 chambres repartis en 2 etages, chacune de ses chambres joliment decoree dans un style zen et epure, revelant le savoir-faire artisanal marocain. Vous pourrez effacer la fatigue de la journee en profitant au riad du Hammam traditionnel, suivi d'un massage a l'huile d'argan. Le salon vous accueille autour du patio calme et paisible. La terrasse vous offre l'opportunite pour profiter d'une vue imprenable sur la Koutoubia et la Medina. ... more less
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Killer in Hebron Carried Israeli Rifle, Settler Says
By JOEL GREENBERG,
Published: March 21, 1994
JERUSALEM, March 20— A settler who drove Baruch Goldstein to the Hebron mosque where he gunned down Muslim worshipers last month testified today that Dr. Goldstein was carrying the same type of rifle that was used in the massacre. His words conflicted with testimony last week that suggested an accomplice may have carried the weapon.
The doctor gave no hint of what he was about to do, the settler, Motti Unger, a security officer on jeep patrol in Qiryat Arba, told an Israeli commission investigating the slaughter.
Three Israeli soldiers guarding the Cave of the Patriarchs shrine testified last week that they had seen Dr. Goldstein carrying an American-made M-16 rifle, not an Israeli-made Galil, the weapon the army says was used to kill at least 29 Muslims at prayer. Two of the soldiers said another settler who arrived after Dr. Goldstein carried a Galil.
But Mr. Unger said he was sure that Dr. Goldstein carried a Galil, a claim also made last week by an army officer on duty at the cave.
On the morning of Feb. 25, Mr. Unger said he was called on his jeep radio to pick up Dr. Goldstein at a local clinic. Dressed for Reserve Duty
"He looked like he was dressed for army reserve duty, and when I went in he was getting organized," Mr. Unger testified. "He asked if I could take him down to the cave. He had a small gray bag and a mini-Galil. There were two attached clips in the gun, and he had two or three other clips."
Dr. Goldtsein drove home, followed by Mr. Unger, and parked his car, then climbed into the jeep for the short ride to the cave, Mr. Unger said.
"He didn't say anything, he talked little -- usually he was not a big talker," Mr. Unger recalled. "He left his car keys and asked that I leave them in his mailbox."
Asked whether the doctor mentioned a revenge attack on Arabs, Mr. Unger said, "There wasn't even a hint."
There was some discussion of ambulance supplies for the settlement, Mr. Unger said, adding that when he proposed a way to keep intravenous infusions warm, the doctor replied: "I hope there won't be any more need for infusions."
Mr. Unger added: "He cared very much about human life." Call From Doctor's Wife
A short time after he dropped off the doctor, Mr. Unger said he heard over his jeep radio that Dr. Goldstein's wife had called the Qiryat Arba security headquarters asking where he was. Mr. Unger said he had radioed back that he had dropped the doctor off at the cave for morning prayers.
When he returned the doctor's car keys, Mr. Unger added, Mrs. Goldstein asked him directly where her husband was, and he repeated his reply. His testimony did not confirm accounts that Mrs. Goldstein, fearing her husband was on his way to attack Arabs, had pleaded in a telephone call that he be stopped.
Ilan Tor, a settler who had been praying that morning at the cave, testified that he had run into Dr. Goldstein, who was wearing an army uniform, a pistol, and "it seems to me that he had a mini-Galil." Point of Entry to Mosque
He said the doctor had appeared "agitated" and had asked him why the door separating the Jewish prayer area from the mosque was bolted shut.
The five-man inquiry commission has repeatedly questioned witnesses about the possibility that Dr. Goldstein entered the mosque through that door.
But Mr. Tor and other worshipers who testified today insisted that the door had remained shut until they heard sounds of shooting.
"I heard several closely-spaced bursts of gunfire," Mr. Tor said. "The bursts sounded like they were coming from the same weapon."
The Jewish worshipers said that they had taken cover, fearing an Arab attack or fighting among the Muslims, and that some of them fled. After soldiers told them to go back, they said, they resumed their Purim services for more than an hour after the carnage. It is unclear how many knew what had happened in the mosque area.
"When I got back home later I heard what had happened on the radio," said Nissim Gudai of Qiryat Arba.
Michael Ben-Shitrit, also of Qiryat Arba, said he had arrived with his teen-age son immediately after the massacre, and had lost track of his boy as hundreds of Muslims rushed out, carrying victims of the attack. Mr. Ben-Shitrit said he later found his son, and, with other settlers, completed the morning service.
He said he was grateful that his son was safe and that no other Jews had been hurt in the incident. "Thank God it all ended well," he said.


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The Mission to Tatooine was one of the final events of The Hunt.
After their success on Malastare, Zam Wesell and Jango Fett contacted Fett's Toydarian friend Rozatta. She informed Jango of a bounty that a junk dealer posted for Jabba the Hutt- Longo Two-Guns. Considering the large bounty, the two set course for Tatooine.
Upon landing in Mos Espa, Jango's jetpack malfunctioned from the heat, forcing him to leave his boost pack behind on the Slave I. He set out into Mos Espa. Longo's gang of thugs desperately attempted to apprehend Fett, but most of them were killed in the firefights waging through the streets. Upon arrival at the podracer hangar where Longo Two-Guns resided, Fett apprehended Two-Guns and hauled in the bounty.
The Hutt explained to Jango that Gardulla houses Bando Gora in her palace, so Zam went to scout out the area around her lair, and Fett landed the Slave I in the Tusken Canyon. While speaking to her on his comlink, he heard ruffling sounds in the background and realized she had been captured. Setting out to the palace on foot through the valley, Fett encountered clans of Tusken Raiders and their massiffs. While making his way through the valley fighting the Tuskens, an execution team feeding criminals to a sarlacc situated in the valley turned their blasters on Fett. The entire execution team was wiped out by Fett and the sarlacc.
Upon reaching Gardulla's Palace, Fett found Zam in a cell. He said he would be back when he had dealt with Gardulla, but Zam thought he would just leave her there and cut her out of the prize. She called for the guards, and Fett was captured and presented to the Hutt. He was stripped of his weapons and armor and thrown into a Krayt dragon arena, where he escaped through a small shaft.
Fett found his belongings and proceeded through the palace, killing gangs of thugs throughout the skiff hangars. He finally found his way to Gardulla's chamber, where he faced the Krayt dragon once again. He blasted the creature dead, and interrogated the Hutt about the Bando Gora. She was devoured by another Krayt dragon after being thrown into the arena by Fett, but she survived due to the inability to digest a Hutt.
Fett told Zam that she had blown it, and he was going to leave her there. While leaving Tatooine, he tried to contact Roz. But Montross answered his call, telling him he found Roz and took all the data she had. Jango immediately set a course for Roz's station.
- Star Wars: Bounty Hunter (First appearance)


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Concepts: Green
$7.00 - $10.00 From $7.00 $7.00
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This listing is for green color family concept bottles. Note: this listing is for the full green color family - meaning that you may receive anything from a neon green all the way to a vampy forest green. I cannot honor specific color requests at this time. Each polish will be randomly selected based off of your selections in the drop down.
How Concept Bottle Sales Work:
Concept bottles are polishes I created for customs, collaborations, or collections that I decided weren't exactly the right fit. These are all items that were made directly in the bottle, so there might be some pigment or glitter stuck to the sides of the bottle. The color, though, still comes out nice and even. I do my best to clean up the neck and cap of the bottle, but there might still be some polish up in the cap. Your bottle will come with a BEGL front label, but the bottom labels will retain their concept bottle code. Please use the drop-downs to specify the finish you'd like to purchase. Concepts are not eligible for discounts as they are already listed at a reduced rate.


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TASCAM'S new X-48mkII is the new and improved version of the original X-48 - the world's first standalone 48-track Hybrid Hard Disk Workstation (co-developed with SaneWave). The X-48mkII continues to integrate the best of both worlds: the stability and ease-of-use of a purpose-built hard disk recorder, with the GUI, editing and mixing features of a computer-based digital audio workstation. The X-48mkII goes beyond mere standalone recorders with a built-in, automated 48-channel digital mixer and powerful editing functions. Plug in a VGA monitor, mouse and keyboard for editing, track naming and monitor mixing - the ultimate multi-track solution for premium quality music, post and live recording applications.
It boasts up to 96kHz/24-bit recording across all 48 tracks. Its file compatibility and synchronization surpass even the TEC Award-winning MX-2424, with native Broadcast WAVE audio file support and AAF export for compatibility with workstations like Pro Tools®, Nuendo and Logic. Support for eSATA hard drives and Gigabit Ethernet allows simple transfer between systems, making it the ultimate multi-track solution for high-quality music, post and live recording applications.
The X-48mkII goes beyond mere standalone recorders -- its built-in, automated 48-channel digital mixer, VGA display output, powerful editing functions and DVD+RW backup drive transform it into a completely integrated workstation.
TASCAM X-48mkII 48-Track Hybrid Hard Disk Workstation Features
Multitrack Recording Features:
Workstation/Mixing Features:
30 Days
1 Year Warranty


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Lingobit unveils its new All-in-One localization tool
Use this security logo:
Buy Lingobit Localizer for $695.00.
Tutorial not found. Let know us about any useful video tutorial.
html, localization tool, software, Html help, translation, builder, exe, web, visual, php, delphi, localizable, dll, resource, database, xml, ocx, asp, translate, chm, localize, mfc, dotnet, java
- A lot of new formats supported (.NET 4.0, Apple, Blackberry and etc)
- Segmentation
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- TRADOS and Bing support
- Productivity features
This software may be distributed freely in its original unmodified and unregistered form. The distribution has to include all files of its original distribution. Distributors may not charge any money for it. Anyone distributing this software for any kind of remuneration must first contact us for authorization.


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Popular Now
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01803 865913
+44 1803 865913
Series: Geoscience (Monographs on Greenland subseries) Volume: 18
By: Ole Bennike(Author)
24 pages, illustrations
Museum Tusculanum Press, University of Copenhagen
Prior to the last deglaciation, probably in the Late Weichselian, glaciers draining the Inland Ice were present in Independence Fjord and J0rgen Br0nlund Fjord, and a glacier draining an ice cap in the north was present in the Borglum Elv valley. It is proposed that glacier fronts were situated at the mouth of Jorgen Bronlund Fjord during a halt in the deglaciation 8000-9000 years BP, and that this halt led to a low initial rate of emergence. J0rgen Brønlund Fjord was deglaciated 8000-7600 years BP. The early Holocene marine limit is c. 65 m above sea-level in the fjord, and c. 80 m east of the fjord. The slow initial rate of emergence was soon followed by rapid emergence. Emergence of the land continued until about 1000 years BP.
Part of the marine invertebrate fauna was established just after deglaciation. The same probably applies to the terrestrial flora and fauna. By 6000 years BP entry of driftwood and southern marine mammals began, and it continues today. Around 4000 years BP the Independence I people made their appearance, later the Independence 11 people and the Thule eskimos inhabited the area.
The geomorphological features show a resemblance to those from valleys in Antarctica.
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Kirk Hammett Talks About His Prize: Peter Green and Gary Moore's Les Paul — See It In Action (11/30/2015)
Metallica's Kirk Hammett owns one of the most iconic and revered electric guitars: a 1959 Les Paul Standard that was previously owned by Fleetwood Mac founder Peter Green and, subsequently, by his disciple, Irish rocker Gary Moore. Hammett, a fa...
Jason Newsted Discusses His Metallica Audition — Video (11/30/2015)
In this new extract from That Metal Show, which was posted to YouTube by VH1 November 30, bassist Jason Newsted discusses his Metallica audition and the death of Cliff Burton. Newsted joined Metallica in 1986 after Burton's death and remained a ...
PRS Guitars Unveils SE 277 Semi-Hollow Soapbar and SE 277 Baritones (11/22/2015)
PRS Guitars recently added two new baritone guitars, the new SE 277 Semi Hollow Soapbar and the SE 277, to its bevy of more affordable guitar model options. Tuned B to B, two and a half steps below standard, the two new baritones offer a taut m...
Seymour Duncan Launches Four- and Five-String Apollo Jazz Bass Linear Humbucker Pickups (11/22/2015)
Designed by Kevin Beller, bass player and Seymour Duncan head of R&D, the Apollo Jazz Bass Linear Humbucker utilizes two coils that sit next to each other under a standard single coil-sized cover. We start with the tone of a traditional sin...
Jimmy Page Plays Led Zeppelin's "Rock and Roll" with Paul Rodgers and Nirvana, GNR Members — Video (11/20/2015)
Last night in Seattle, at the Experience Music Project Museum, a group of musicians got together to honor Jimmy Page. But no one expected the former Yardbirds, Led Zeppelin and Firm guitarist to actually perform. Then, as the night (and the Fi...
Rodrigo y Gabriela Premiere "Continuum" from 'Jaco' Soundtrack — Exclusive (11/18/2015)
Today, GuitarWorld.com presents the exclusive premiere of Rodrigo y Gabriela's new cover of "Continuum," a classic Jaco Pastorius track from his self-titled 1976 album. Rodrigo y Gabriela's new interpretation of the song is one of the highlights...
Alex Skolnick and Dave Ellefson Talk Metal Allegiance, Premiere "Can't Kill the Devil" Playthrough Video (11/17/2015)
"This is like a musician fishing trip," says Megadeth bassist Dave Ellefson on the final day of the Winery Dogs Camp. Ellefson and Testament guitarist Alex Skolnick were hired as guest instructors for the event, now in its second year. Prior t...
Steve Vai Talks Tony MacAlpine Benefit Show, Upcoming 'Passion and Warfare' Remaster and Next Vai Academy (11/16/2015)
As recently reported, guitar greats Steve Vai, Zakk Wylde and John 5, along with drummer Mike Portnoy, bassist Billy Sheehan and keyboardist Derek Sherinian, are joining forces to play a benefit concert for guitar and keyboard virtuoso Tony MacA...
John Paul Jones Performs Led Zeppelin's "When the Levee Breaks" with Former R.E.M. Members — Video (11/16/2015)
Late last week, former Led Zeppelin bassist John Paul Jones joined former members of R.E.M. on stage in Norway to perform Led Zeppelin's "When the Levee Breaks." That performance, which you can check out below, took place as part of a "mini fest...
Watch the Official Trailer for 'Jaco,' Robert Trujillo's New Jaco Pastorius Documentary — Video (11/13/2015)
Metallica bassist Robert Trujillo has released the official theatrical trailer his new Jaco Pastorius documentary, Jaco. You can watch it below. The film chronicles the brief-but-extraordinary life and career of Pastorius, the remarkably talente...
Randy Rhoads' Mother, Delores Rhoads, Dead at 95 (11/12/2015)
Randy Rhoads' mother, Delores Rhoads, has died. She was 95. Bassist Rudy Sarzo, who played with Randy Rhoads in Quiet Riot and Ozzy Osbourne's band, broke the news yesterday via his Facebook page. "The world today has lost one of the most gracio...
Friend of Duff McKagan's Wife: "Guns N' Roses Are Coming Back, MFers!" (11/11/2015)
Did a friend of Duff McKagan's wife just reveal that the original Guns N' Roses are reuniting? On November 3, as Susan Holmes-McKagan and her pal Brandi Glanville were being interviewed at Rhonda's Kiss All-Star Benefit Concert for cancer in Los...
The Zombies Premiere "Moving On" Music Video — Exclusive (11/11/2015)
Today, GuitarWorld.com presents the exclusive premiere of "Moving On," a new music video by the Zombies. The track is from the legendary British band's new studio album, Still Got That Hunger, which was released October 9 via The End Records. Th...
Stéphan Forté Premieres Uncensored "Sector A Undead" Music Video [NSFW] — Exclusive (11/11/2015)
Today, GuitarWorld.com presents the exclusive premiere of "Sector A Undead," a new NSFW music video by Stéphan Forté. The track is from Forté's latest album, 2014's Enigma Opera Black. "Being a big horror movie fan, I've always wanted to do a sh...
Readers' Poll: Best Rock Headphone Song Ever — "Comfortably Numb" (Pink Floyd) Vs. "Dogman" (King's X) (11/9/2015)
What, exactly, is a headphone song? The definition changes depending on who you are. For audiophiles, a headphone song—or album, for that matter—is a work that is so exquisite that it demands you listen to each beautifully recorded note under a ...
Bassist Zack Merrick on All Time Low's Past, Present and 'Future Hearts' (11/6/2015)
For guys who are only in their mid-twenties, All Time Low—and their pop-inspired punk sound—have experienced a great deal of success. In the 10 years since starting out as a group of high schoolers from Baltimore...
Steve Vai, Zakk Wylde and John 5 Join Benefit for Tony MacAlpine (11/6/2015)
Steve Vai, Zakk Wylde and John 5, along with Mike Portnoy, Billy Sheehan and Derek Sherinian are joining forces to play a benefit concert for guitar and keyboard virtuoso Tony MacAlpine, who was recently diagnosed with colon cancer. The Benefit...
Mr. Big's Paul Gilbert and Billy Sheehan Team Up for Monster Performance in 2009 — Video (11/6/2015)
For today's Friday Flashback, we revisit June 20, 2009, when Mr. Big performed at the world-famous Budokan in Tokyo, Japan. During the second half of the band's set, which is available as an impressive CD/DVD called Back to Budokan, bassist Bill...
Nashville Power Trio Simo Offer Free Download of New Single, "Long May You Sail" (11/5/2015)
Today, GuitarWorld.com and Simo have teamed up to offer a free download of the band's new single, "Long May You Sail." The song is from the Nashville power trio's new album, Let Love Show the Way, which is scheduled for a January 2016 release vi...
Readers' Poll: Best Rock Headphone Song Ever — "Crystal Skull" (Mastodon) Vs. "Dogman" (King's X) (11/5/2015)
What, exactly, is a headphone song? The definition changes depending on who you are. For audiophiles, a headphone song—or album, for that matter—is a work that is so exquisite that it demands you listen to each beautifully recorded note under a ...
Javier Reyes' Mestis Premiere New Album, 'Polysemy' — Exclusive (11/3/2015)
Today, GuitarWorld.com presents the exclusive premiere of Polysemy, the new album by Mestis, a new project fronted by Animals As Leaders guitarist Javier Reyes. The album, which will be released November 6 via Sumerian Records, showcases Reyes' ...
Dimebag Darrell's Riffer Madness: How to Bust Out of a Rut — Lesson with Tab (10/30/2015)
This entry comes from Dimebag Darrell's classic Guitar World column, "Riffer Madness." What's up, Daddy?! This month we're gonna talk about some ways you can dig yourself out of a playing rut. Whenever you get into a rut, always try and remember...
Guitar Smashers: The 11 Deadliest Ax Wielders of All Time — Video (10/29/2015)
Musicians are a temperamental lot. When the music is flowing and the vibes are good, we couldn't be happier. But if our guitars won't tune, the audience is a drag or the P.A. sounds like crap, all bets are off. Oddly, the objects of our wrath ar...
Positive Grid Launches BIAS Pedal, the First Tone-Match Distortion Modeler — Video (10/29/2015)
Positive Grid, creator of the best selling BIAS Amp and BIAS FX guitar amp processors, today announced the launch of BIAS Pedal, the first cross platform distortion processor for both mobile and desktop devices. For the first time, guitarists an...
Keith Richards' Guitar Tech Reveals Keef's Studio Rig (10/29/2015)
"Bring me the usual, plus surprise me." That's what Keith Richards would generally tell his longtime guitar tech, Pierre de Beauport, before the start of a session for Crosseyed Heart. It was de Beauport's enviable job to visit Richards' equip...
Kirk Hammett Confirms Metallica Are Recording New Album (10/29/2015)
Kirk Hammett has confirmed that Metallica are indeed working on their next album. HeavyMetalAbout.com asked the guitarist if it's "freeing" for Metallica to be at the point in their career where they don't have to record studio albums. "Absolute...
Crown of the Continent Guitar Festival 2015: Guitar Heaven with Dweezil Zappa, Lee Ritenour and More in Idyllic Bigfork, Montana (10/28/2015)
This past September, I had the great privilege of being asked to participate in the sixth annual Crown of the Continent Guitar Festival in Bigfork, Montana, as an Artist in Residence, where I served as an instructor in group and private capaciti...
Wrecking Crew Legend Carol Kaye Gives Kiss' Gene Simmons a Bass Lesson — Video (10/28/2015)
In the world of bass guitar, Carol Kaye is a legend. Kaye, who turned 80 earlier this year, was a member of LA's legendary "Wrecking Crew" and is known as one of the most prolific and widely heard bassists, playing on an estimated 10,000 session...
Ne Obliviscaris Premiere "Painters of the Tempest (Part II) Triptych Lux" Playthrough Video — Exclusive (10/28/2015)
Today, GuitarWorld.com presents the exclusive premiere of a new playthrough video featuring bassist Brendan Brown of Australian extreme progressive metal band Ne Obliviscaris. The song, "Painters of the Tempest (Part II) Triptych Lux," is from t...
Jimmy Page Plays Chopin at 1983 ARMS Concert — Video (10/27/2015)
Jimmy Page has demonstrated his guitar talents in a range of musical styles over the course of his career, from hard rock to folk. And for one celebrated event, he dabbled ever so briefly in classical, when he adapted Frédéric Chopin's Prelude i...
2016 Experience Hendrix Tour Will Roll Through U.S. in February and March (10/27/2015)
The Experience Hendrix Tour—often hailed as the guitar event of the year—is set to return in 2016. This next edition of the Experience Hendrix Tour will include 27 performances in February and March, stopping in more than two dozen cities along ...
Rudy Sarzo on Randy Rhoads' Mentoring, Quiet Riot's Documentary and the Joys of "Fitting In" (10/23/2015)
Rudy Sarzo. For more than 35 years he's played bass alongside some of the biggest names in rock, including Ozzy Osbourne, David Coverdale and Ronnie James Dio, but what Guitar World readers really want to know is… Why do you think you have been ...
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The Blackman Lady Blaze head to Cleveland, TN to take on Bradley Central. A hard fought game, but Blackman could never sieze control. They fall 55-46.
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Friday, July 9, 2010
Spotlight: Paris
Paris. Where something is always happening.
Friday is here! I cannot believe it—in fact, for some reason, when I woke up yesterday, I thought it was only Wednesday, and was sadly amiss of the week that seemed to fly by... but, I'm looking forward to spending some time outdoors in between working. It was so nice to eat dinner and enjoy some rosé outside last night, as it was actually cooler outside than it was in the house! (a post on an amazing house coming later on today) But, on to today's topic:
The beautiful, magical streets of Paris are sprinkled with fashion's elite—a mix of experts, onlookers, press, society, and fashion lovers. The energy is high, and the fashion world is in full swing, surrounded by an exciting and jovial buzz... there is so much happening in fashion right now, and while we're enjoying viewing all of the recent, exciting shows and collections, like Valentino / Eli Saab / Armani Privé / Givenchy / Chanel / Christian Dior and more, I find just as much enjoyment in observing the spectators—some of these outfits are just extraordinary! Which one(s) do you like best?
( images: style.com, by: Tommy Ton )
20 comments:
Oh mine do I have to pick just one? I love pretty much all of them and would LOVE to be a guest in one of these shows at least once in my life. Looking all fabulous, hair done, amazing heels.....hmmm one day. xoxo!ReplyDelete
The first is a stunning picture! Hanneli also always looks pared down and beautiful, Natalia dashing away in that bouquet of a dress is wonderful. Belle Paris indeed!ReplyDelete
Wow your blog is beautiful... I am in love with that last dress with the flowers - so pretty! But that red is also so fabulous...ReplyDelete
Hi Sarah,ReplyDelete
I think that #5 is the most elegant..I would to dress it,
Enjoy your weekend and rest Sarah,I have a wonderful and relaxing pool in my ventana.....
Hugs from your spanish friend
oh Sarah, so beautiful images. I adore the shoes on the first one, the dress on the last one, the dress with daisies and the white blouse... everything! hope you have a fabulous weekend, darling! xoReplyDelete
What incredibly chic women. I'm itching for a trip to Paris!ReplyDelete
C -- I think Natalia's dress is my favorite of all. It's so soft, delicate + floaty...ReplyDelete
Desde my Ventana -- I cannot wait to see!
Caitlin -- me too :)
I need to go to Paris!!! Dave may get to go for work in September and I'm dying to tag along....ReplyDelete
Oh I agree, I just love looking at the fashion on the spectators as well.ReplyDelete
I love the contrasting looks of pic #2 and Hanneli always looks fantastic.. Oh and love the last one too.
Averill -- you must! You would love it, I think...ReplyDelete
oooh, ccan't pick just one! my faves are 1,4 and 8 - just gorgeous! Love this post Sarah!! jxxReplyDelete
These are FEROSHHHH Miss Sarah! What a post!ReplyDelete
Gooorgeous. Can you imagine being there right now?ReplyDelete
I agree - the spectators are almost as good as the models!!
Something about this city is truly magical! Gorgeous post Sarah, hope you are having a lovely weekend xxReplyDelete
Such stunning images, Sarah! Thanks for posting, darling. Have a happy Sunday!ReplyDelete
I love everything about this post, the hair the effortless beauty and of course the dresses and shoes,ReplyDelete
What a wonderful photo journal depicting the world of fashion in Paris. Thank you for sharing! Hope you had a great weekend.ReplyDelete
Such lovely photos--loved Caroline, Olivia, Margherita...so much great stuff.ReplyDelete
I think Olivia's dress is my favorite. I like the combination of the black patterned dress with the bright colored clutch.ReplyDelete
Carolann -- Mhm! Olivia can do no wrong in my mind!ReplyDelete


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On the ultrastructure of the developing and adult mouse corneal stroma
- Accepted:
- Citations
- 84 Downloads
- 1.
Immediately after the separation of the lens vesicle, the mesenchyme cells migrate into the cornea analage.
- 2.
There is no collagenous primary stroma in the mouse embryo.
- 3.
During days 12–14 the stroma cells (fibroblasts) differentiate and develop the organelles required for ICS (intercellular substance) secretion.
- 4.
In the posterior region of the stroma, the collagen fibrils are deposited in bundles approximately perpendicular to each other.
- 5.
The adult mouse stroma is divided into 2 zones. In zone I the subepithelial fibrils are randomly distributed and are not bundled (rudimentary Bowman's membrane). In zone II the fiber bundles lie in the plane of the cornea and form a highly ordered three-dimensional network.
Basic differences between the mouse and other species are discussed.
Key wordsCornea Collagen Fibrillogenesis
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Yoga makes me a better
Catholic yogi (or rather, yogini, because "yogi" is masculine in Sanskrit and baseball)]
Heidi Schlumpf | May. 5, 2016 | National un-Catholic Reporter
Earlier this spring, some Christians in Georgia protested a yoga class designed to help students at a public elementary school deal with stress. In response, the school district declined to drop the class but agreed to skip putting hands to the "heart center," using the word "namaste" or having the children color mandalas.
It wasn't the first time Christians — usually evangelicals or more traditionalist Catholics — have complained about the popular exercise that originated in Hinduism in India.
Even Pope Francis seemed to dis yoga last year in a homily about the Holy Spirit. "You can follow a thousand catechism courses, a thousand spirituality courses, a thousand yoga or Zen courses, and all these things. But none of this will be able to give you the freedom as a child [of God]," he said. "Only the Holy Spirit."
To be fair, the pope also noted that catechism classes weren't as powerful as the Holy Spirit. Still, to all these folks getting stressed about yoga, I say: "Take a deep breath in … and out."
As someone who has practiced yoga for nearly two decades, I can tell you that it's actually made me a better Catholic.
In legal battles, the counterargument is that yoga is merely a bunch of stretching exercises, not a spiritual or religious practice. That's what happened in Encinitas, Calif., a few years ago when two courts eventually ruled that the exercises in the physical education classes were not spiritual and thus do not violate the separation of church and state.
It's true that for many — including those doing the "tree pose" with 6-year-olds in gym class — yoga is merely a physical exercise. That may also be the case for many adults who flock to yoga classes at gyms, seeing the stretching as a rotation in their running or weightlifting schedules. For those who focus merely on the physical practice, yoga is about strengthening core muscles, attaining balance or being able to put your foot behind your head.
But for real yogis, it's much more than that. In fact, the history of yoga is connected with Hinduism, and the postures and breathing are designed to facilitate meditation. It's about spiritual perfection, not perfect bodies. In meditation, we set aside our thoughts, some say "empty" our minds.
That worried Jeremy Butler of the Christian Apologetics & Research Ministry, who wrote in response to the Georgia controversy: "We are not to focus on ourselves or to clear our minds. The Bible never gives us a prescription to free our mind."
Instead, he argued, Christians should meditate only on God and God's word.
That's a pretty narrow definition of prayer. For me, anything that slows down my hectic life is a good thing — and not just because it aids relaxation and de-stresses. Meditation is just another name for prayer.
In the quiet, God slips in. That's why so many religions have some sort of quiet, meditative prayer practice. For some Catholics, it's praying with the Blessed Sacrament. For others, it may be centering prayer. Still others find it on their yoga mats.
Yoga as part of a spiritual path shares other things in common with Christianity. The focus on the breath echoes language about the Holy Spirit. The repetition reminds me of the rosary. And its emphasis on regular practice sounds almost Sabbath-like.
Some have attempted to "Christianize" yoga — but again that comes from a perspective that sees "regular" yoga as dangerous to their faith lives.
Nothing could be further from the truth. Clearly, the millions of yoga aficionados during the practice's most recent popularity craze have not converted to Hinduism. According to the Pew Religious Landscape Study, any increase in the number of Hindu adherents over the past decade has come primarily through immigration, not conversions. Only 10 percent of American Hindus are converts.
For some yoga practitioners who see it as a spiritual practice, yoga may replace traditional religious practice. They may already be "nones" who are unaffiliated with a denomination or religion. For me, as I do with any other religious practice from a tradition outside my own — say, Jewish mourning practices or the Protestant practice of tithing — I am able to incorporate what fits with my Catholicism, and leave the rest. Christians have been doing this for centuries.
Yet, I'd be lying if I didn't admit that there are some aspects of yoga as a prayer practice that especially resonate with me — even more so than some Christian practices.
For example, the fact that yoga is nonhierarchal is appealing. The "teacher" in a typical yoga class is there to offer only suggestions, not dictate any individual's practice. While some "gurus" serve as spiritual guides, this is not common in the U.S. practice of yoga.
Finally, and obviously, yoga is about the body — with which, sadly, some aspects of Christianity have had a bit of a hate-hate relationship throughout history. With yoga, I have come to accept and even celebrate my body, but at the same time not become too obsessed with or attached to it. I believe an incarnational God calls us to do the same, although the church has not always lived out that teaching.
Yoga is not a threat to my faith. It's been an asset to it — and it can be for many Catholics and other Christians. Sure, downward dog will give your hamstrings a good stretch. But if you could stand to be stretched in the spiritual department, don't be afraid to sit in lotus, do some deep belly breathing and, yes, even chant, "Om."


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The great mountain ranges are some of the planet's most spectacular landscapes, but they are unforgiving places to live in, and only a few animals have what it takes to live at extreme altitude. Mountain animals are amongst the most elusive in the world, and this film provides unique and intimate glimpses into their secretive lives. Witness the moment four snow leopards come together when a mother and cub become trapped between two rival males. Join grizzly bears as they dance against trees to rub off their winter fur and soar with golden eagles hunting amongst Europe's snow-capped peaks.
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Just one random thought as the NFL continues to cope with the recent passing of iconic Raiders owner and Hall of Famer Al Davis.
Though the Silver & Black won Sunday in Houston while wearing white road jerseys packed before Davis' passing, it would seem an appropriate tribute to the franchise patriarch for the Raiders to don their funereal black jerseys for the rest of the season. (We'd even suggest black pants and helmets with silver trim, but the NFL licensing and trademark folks might not go for that.)
The team has six more games in Oakland, where it almost always opts for black -- though white has been worn at home as recently as 2008 and 2009. But of its five remaining away games (San Diego, Minnesota, Miami, Green Bay, Kansas City), only the Chargers and Dolphins frequently wear home whites -- thus enabling the Raiders to go black -- and usually only early in the season to reflect a hot summer sun.
The club has already affixed a sticker to the back of its helmets with the word "Al" superimposed over the Raiders shield.
But given the persona Davis imbued in the Raiders, his beloved uniforms and the somber occasion of his passing, it just seems apropos that the team actually be Silver & Black for the remainder of a 2011 campaign that marks the end of an era.
Nate Davis is a reporter, blogger and editor who's been at USA TODAY since 2000. He has covered the NFL since 2005. No, he did not play quarterback for Ball State. Davis' succession of our esteemed colleague Sean Leahy at The Huddle is considered a Brady-for-Bledsoe swap by most "insiders."More about Nate


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Reviewer Bio:
Hello there! My name is Sam and I am a massive book lover, since I could first read. YA books are a favorite of mine, as well as historical romance, NA, but that doesn't mean that I don't read other things, I just really prefer these. Music is also a large pleasure of mine, I'm listening to something all the time especially when curled up with a good book. I'm a bubbly, smiley Sam by day and a ninja by night. Well, I used to be but I'm too gravitationally challenged. I am in love with more male characters in books than I think would be okay to mention here, or anywhere ^.^
A Family Affair - Jennifer Wenn
Against the Odds - Senna Fisher
Alexandra Drake Series - Sarah Elizabeth Ashley
Back To Reality - Danielle Allen
Beasthood - A.Z Green
Before I fall - Lauren Oliver
The Blood of Titans - C. Michael Forsyth
DarkChild (Episodes 1-3) - Adina West
Deja Vu - D.J Starling
Displaced - J.F Jenkins Review
Do Me, Do My Roots - Eileen Rendahl Review
Don't Make Me Beautiful - Elle Casey
Fantasyland - DJ Starling
Fairest (An Unfortunate Fairy Tale)
Family Magic - Patti Larsen
Forever Changed - Belinda Boring
The Mine - John A. Heldt
My Life With Snoopy - Joey Camen
The Mystic Wolves-Belinda Boring
Seven Bullets - Cloud Buchholz
The Sexual Adventures of Time and Space - Brian Sfnas
Shine Not Burn - Elle Casey
Significance (A Significance Novel) Review
Silence - Natasha Preston


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The long way home
In From Heaven Lake, Seth mingles historical fact with poetic description and telling anecdote to take the reader along effortlessly.
Conversations and people can convey more about a place than several turgid paragraphs and Seth knows this well.
The other day in the hills I rose, after many years, to the sound of a cock crowing. Compared to the metallic, penetrating cell phone alarm that is the gift of technology to us, the cock-crow was sweet music. And the cloud had rolled up right to the large glass window, swallowing the heart-numbing sight of several half-built houses, gouged hillsides and handsome pines felled while asleep.
For a moment, I was once again the teenager of a lifetime away, treading lightly with the goats from the little village of Ani where the young and vigorous Sutlej rushed under a narrow bridge, to the village of Khanag, hidden high up among the conifers. Leaving the crystal-clear stream with its churning water-mills, we began the climb upwards, lunching against large rocks on parathas and mango pickle, when the cloud rolled down, like some lazy white pillow, from the mountain crest and covered everything in sight with a thin magical haze. It was the same sort of cloud again and holding on to the vision, I began to scour my shelves for travel books once again, books that would talk of unknown roads, open starlit skies, trains whistling in the dark...
A clutch of books presented themselves and in the coming weeks I will drift through them, wistfully and randomly, as these books deserve to be read. There is Chatwin's masterly The Songlines, Kerouac's Lonesome Traveler, Eric Newby's A Traveller's Life and Peter Fleming's One's Company. And a special re-rea d is reserved for that mother of all travel books: Robert Byron's Road to Oxiana. It is possible that any or all of them may surface more than once in this column at some time but today I will prefer to stick to a slim travelogue, From Heaven Lake: Travels through Sinkiang and Tibet, written by a young Vikram Seth before he amazed us with the sheer inventiveness of The Golden Gate and then staggered us with his wrist-wrenching magnum opus A Suitable Boy.
Seth spent two years as a student at China's Nanjing University and, in the summer of 1981, as he announces almost casually in the introduction, "returned home to Delhi via Tibet and Nepal." His journey begins in the towns of Urumchi and Turfan on the northern branch of the ancient silk route, hot Xinjiang towns crowded with flies, donkey carts and watermelons and not far away, at the intensely blue Heaven Lake, surrounded by green mountain walls and fed by the snowmelt from the Mount Bogda ranges, which sit "abrupt like a shining prism laid horizontally on the desert surface." Like for so many of us who have worked or travelled in China, the former Soviet Union or West Asia, the immortal words of Awara Hoon open an unexpected door for Seth and he obtains a permit to travel by land to Tibet. Like any traveller, and particularly any travel writer, worth his salt would, Seth immediately begins to hallucinate on visions of yaks, trucks, lamas and the sloping white walls of the Potala palace rising forever into a cloudless azure sky. Not knowing quite how, he plans to cross over from Tibet into Nepal and then onto India.
But before that, he has a long way to go. First there is the frustrating detour to the east; to Xian (which reminds him "irresistibly of Delhi, with its "broad streets, dryness, the shop canopies leaning out over the pavements, the bicycle-riding white-shirted population") and to Nanjing and Beijing, to pick up his passport, more money and the essential cell for the light meter of his Nikon. That light meter was well worth the effort: the book has some telling black and white photographs, showing sunburnt faces of smiling Uighurs and Tibetan yak herds, a desert storm building up over Liuyuan, trucks stuck in a desert flood, the oasis silk-route town of Dunhuang and of course, the Potala. Hitch-hiking on random passing trucks, closeted with chance acquaintances, a group of teachers, even a bunch of chickens, the writer moves on relentlessly towards Lhasa, crossing the lonely Chaidam Basin and then over the Kunlun range and onto the Qinghai-Tibet plateau.
In the classical manner of the successful travelogue, Seth tells the story of his journey with complete honesty. Mingling historical fact with the poetic description and telling anecdote, he takes the reader along effortlessly. Conversations and people can convey more about a place than several turgid paragraphs and Seth knows this well. He does not hide his frustrations and his fears or even his headaches. He bluffs his way, trades cigarettes, uses his "foreignness" when required and loses his temper with disturbing regularity. Most important, he does not romanticise: despite his yearning to see the Potala he describes the experience of being pushed around by a relentless juggernaut of pilgrims like someone coming out of a wringer, the rotting dirt of Lhasa is not swept away by sentimentality and an idyllic Nepal night is truthfully marked by mosquitoes, flies and bloodsuckers. And of course there is the beauty too, of the landscape, of flute music, of a "light paper kite, rhomboid, tail-less, like the ones we have at home, a prisoner of string and wind, flying now in one direction, now in another, with no appraisable trend or endeavour."
Ultimately, overcoming bureaucratic imponderables and floods, he does cross over into Nepal, without knowing that he has done so, on some green slope in the Himalayas, and is greeted with the sight of a woman in a sari washing clothes at a stream, quite oblivious whether she is one country or the other. From there to Delhi airport, a bottle of duty-free Glenfiddich in his hand, is a short journey. And yes, one early morning, at the spring-fed lake at Nanhu, he too is woken up by an insistent cock-crow.


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Whitney's Story
A Family Affair
Whitney witnessed her mother's growing success with Aflac—as well as a few of her siblings—and decided to try the company out for herself. She felt that her family's personal endorsements spoke volumes about the quality of the company, trusting they would only steer her in a direction where she could achieve extreme success.
What Whitney Does
District Sales Coordinator
Whitney's working hours differ from day to day, depending on her client's schedules and who she might be mentoring at the time. She helps people find affordable ways to enhance their current insurance benefits through Aflac's supplemental insurance products, and also mentors other teammates on how to achieve the same kind of success with their own customers.
Genuine Appreciation
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"We always leave our company conventions with lots of new friends."
"This job is very exciting, and full of adrenaline. I never get bored."
More People
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Whitney Millwood
District Sales Coordinator
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Tristan Gaines
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Ediana Martinez
District Sales Coordinator
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