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The ''What to do in Montreal'' Thread version 4.0
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Join Date: Jun 2002
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Originally Posted by
Hey guys, I've got a few questions about LIVING in MTL.
My employer is offering me a job in MTL (near downtown/old MTL, it's on Notre Dame W.). I'm not a fan of downtown in general, I'm looking for a quiet family-centered neighbourhood that wouldn't be too much of a commute to that area everyday.
Originally I was thinking of living in Laval, then I looked at Brossard, which seems nice upon google streetviews. I'm just looking an area that's away from noise (traffic, people, bars, etc.) but still reasonably close to downtown mtl (30-35mins by car, possibly a bit more by bus). I would like an area that has some trees and parks as opposed to buildings upon buildings.
Which areas should I be looking at? What's convenient but also has good "greenspace"?
Are you looking for a condo, apartment, or house?
That area itself isn't bad, in fact. There are some nice places to live around there, and it's not too noisy.
If you want to be far from noise and in a real suburb-like area, then you'd have easy access over the Victoria bridge. Depends on the hours you work, but it's convenient and, outside of rush hour, it's an 8min drive away or so from your work.
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It's that time of the week again where I drop the weekly news. I'm writing it because nobody else would. Thing is...I don't care. I love it.
The Sims Wiki - Weekly Community Blog
The Sims news
Dead week. Here's what I dug out from Google.
- The live broadcast for Dragon Valley drops tonight (GMT/UTC). There is also the chance to meet the team behind The Sims 4. Should be interesting.
- 18 days until E3. Perfect opportunity for EA to drop a trailer for The Sims 4.
- The Sims 3 for console won't work on the Xbox One (or the PS4). Yeah well it was dead this week. </filler content>
Wiki news
- The Tutorials namespace was renamed to Game Guides. Check them out today!
- Inobligatory Community discussions link. Please stop by and have your way. Remember, you as a user can help decide the future of The Sims Wiki.
- While I'm here, please specifically have your say on a thread addressing issues with RfA/RfB requests/nominations so that we can get around to fixing it.
I'm done with the weekly roundup. Please send any issues you have with this blog to firstname.lastname@example.com and an advisor will
not get back to you. Lost Labyrinth • (c) • (b) 11:30, May 23, 2013 (UTC)
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Top Best Engineering Colleges 2016 in Telangana Rank Wise List
Top Best Engineering Colleges 2016 : The Top Engineering colleges are listed in huge number and Hyderabad is getting vast in term of giving good education to the students. The students, who completed their intermediate, look for the B.Tech colleges and this is one of the crucial steps that decide the future of the students.
There is an entrance test conducted in the top listed Engineering colleges in Hyderabad every year where the students interested in particular college has to go through the test and get good numbers to get the admission.
Top Best Engineering colleges in Hyderabad 2016
In order to get a seat in engineering colleges, the students work hard and before taking the admission, makes completed check on the background of the college. They see the faculty, famous recruitments, good environment and lots more.
The Telangana State holds an EAMCET exam each year where the students appear for the exam in huge number and depending upon the ranks, the admissions are based. The student has the option to choose their own preferable subject and depending on the chosen subject, they will be further selected for the counseling.
Finding a seat in top listed Engineering colleges in Telangana is as difficult as that of reading a new language. Everything has become commercial these days and the seats are paid for in the colleges. We can help you to find the top listed engineering colleges in Hyderabad for the year 2016, where you can check for and go through the portal and select the best-suited one for you.
The intuitions are many in number but we have come out with the top one in Telangana. Go through the list and have a brief idea about the type of the institutions of your choice that provides best Engineering studies in Telangana.
Top 25 B.E/B.Tech Private Engineering Institutes Rankings 2016 in Telangana


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Selling drivetrain from a Fox Body Mustang GT that was in the 72Z I am doing a Laine conversion on. Engine is complete except for distributor, injectors and fuel lines. Bores look good but no clue as to bottom end. Headers, starter water, pump attached. I would run it on a stand before install $150, pickup only. AOD is complete, fluid was clean. $75, pickup only. 8.8" rear axle complete from hub to hub with disk brakes and air shocks with 3 link. $100, pickup only. email if u want photos firstname.lastname@example.com
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New Markets Venture Partners is an early and growth stage venture capital firm that invests in and helps build disruptive education, information technology, and business services companies.
As one of the leading education technology-focused venture firms in the U.S., with nearly 20 years experience, the New Markets philosophy is:
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We add value before, during and after the investment process.
We believe in structuring a fair deal, properly capitalizing investments, and aligning resources to achieve the most advantageous outcome.
We are true partners with our portfolio companies–working together to grow.
Learn about our investment impact, philosophy, and criteria for investing.About New Markets
Meet the Team
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Efficacy in Education Technology
As a smart education technology investor, New Markets has always been focused on product efficacy. Since our earliest days, we've asked companies about the precise [...]
Behavioral Science Startup Secures $3.4 Million in Series A Financing to Support Student Engagement and Retention
Motimatic, a mission-driven startup that pairs behavioral science with leading-edge advertising techniques to deliver motivational content to college students, today announced that it has secured [...]
Regent Education Secures $8.5M in Funding
Regent Education, the leader in automated financial aid management and enrollment optimization solutions, today announced it has completed an $8.5 million round of funding with [...]
Regent Education Appoints Jim Hermens as CEO
Regent Education, the leading provider of financial aid and enrollment management software solutions, recently elevated Jim Hermens to the role of CEO, succeeding Randy Jones. As CEO, Hermens will [...]


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Sponsor, Exhibit and Present at the Mid-Atlantic Marketing Summit: Washington 2013
Capitol Communicator & Tech Wire Media
Friday, April 19, 2013 from 7:45 AM to 5:30 PM (EDT)
Sponsorship Summary
This summit, first held in McLean, VA, in April 2012 and then in Baltimore in October is the region's premier event in marketing, technology and media. This year we are adding sessions for sales, marketing and business development executives. The one-day events brought together sell-out gatherings of over 700 marketing and communications professionals to discuss high-level issues through a series of panels, keynotes, presentations and networking.
These events are co-produced by Capitol Communicator, the regions source for marketing and communications news and with Potomac Tech Wire, the region's source for technology news. The themes focus on emerging technologies and trends in marketing communications. Topics include: metrics, mobile, sales, business development, multi-platform campaigns, online video campaigns, experiential advertising, B2B, B2C, and much more.
The summits explore the disruptive technologies that are creating a major shift in how marketing and communications professionals reach their audiences and decision makers. Attendees include CMOs, advertising, public relations, sales, marketing and business development executives, entrepreneurs, investors, technologists, brand marketers, creative directors, sales & business development, researchers and media planners. Over 60% of attendees have been management level and above at past summits.
Who Attends
Over 60% of attendees from past MAMS were senior-level executives. The following is a partial list of companies that have attended past Mid-Atlantic Marketing Summits:
1-800-PACK-RAT, 15Four, 15Four Video Strategy, 3Pillar Global, 48 Hour Film Project, Inc., 501digital, LLC, 522 Production, AARP, Accella, Accenture, Aerotek, AIA, Ainsley & Co., AirPatrol Corporation, AKQA, Allied, Allinio, Alston Marketing Group, American Bankruptcy Institute, American Public University System, American Red Cross National Headquarters, AOL, API, Aquent, Archdiocese of Baltimore, Art Litho, Arxan Technologies, Aurigma, Inc., Autodesk Consulting, Avectra, B2B Marketing Source, LLC, Balance Interactive, Bates Creative Group, Beekeeper Group, Berlack Communications, BH Media, Blackboard, Borenstein Group, BoxTone, BreakRock, Brocadiant Legal PLLC, Buckley & Kaldenbach Inc., BurrellesLuce, Business Wire, Cambridge Strategic Partners, Capital One, Carousel30, Carpathia Hosting, Inc., Center for Vein Restoration, CentreTEK Solutions, CFG Community Bank, CHIEF, Ciena, Citybizlist, Clean Cuts Music, Clements Worldwide, Clepper Media Consultants, LLC, Comcast Spotlight, ComericaBank, CompuGain, comScore, Context Partners, CortaniMorrison Advertising and PR, Coyle Studios, CreatiVerge, Crosby Marketing, CRT/tanaka, Custom Fitness Concepts, CustomInk, Decision Lens, Department of Homeland Security, Dezenhall Resources, Dixon Hughes Goodman LLP, Dominion Enterprises / Boats.com, Donna Arbogast & Associates, Dormify, DoublePositive, DPR Group, Earth Networks - WeatherBug, Edison Ventures, Elevation, Ellucian, Eloqua, Enabledware, EnergizeGrowth LLC, Eno Center for Transportation, Environics Communications, Evolve Communications, ExactTarget, Executech Strategic Consulting and DoD National Defense University iCollege, Extraordinary Events, EyeForContent.com, Fairfax County Economic Development Authority, Federal Resources, Fixation Marketing, Fleishman Hillard, Foxtrot Media, Frontline-Exhibits, Gannett, Georgetown University, Geostellar, Inc, Glass Jacobson, GlobalSpec, Goldman Sachs, GoodData, Google, Granite Partners, GraphTec, Green Vista, Group82, Guident, GWPI, Havit, HBP/Balmar, Heimlich Group, LLC, Henninger Media Services, HubSpot, Hy.ly, HZDG, ICF International, IMG, immixGroup, Infinitive, InScope International, Insight Consulting, Insight180, Institute for Excellence in Sales & BD, Interactive Advertising Bureau, Intermarkets, Inc., iStrategyLabs, JWatson Creative, K+G Services, Karen Falk Markeing Communications, KG Communications, Kinsella Media, KK Design LLC, Korn/Ferry International, LeadLIfter, Len The Plumber, Leverage Marketing Agency, Lifedash, Inc., Linksoft Innovate, LLC, LLR Partners, LMI, LM&O, LogiXML, London Ink, Marketo, Inc., Marriott International, McGladrey LLP, MD Transportation Authority, MDB Communications, Media Fusion Ine./NASA, Media Two, Merkle, Merritt Group, Message Systems, MetroStar Systems, MGH, MicroTech, Millennial Media, Millennium Marketing Solutions, Inc., Milner-Fenwick, Inc., MindCruncher, MindFarm, MITRE Corporation, Monetate, MorganFranklin Corporation, MPB Strategies, MSBD, Inc., MsgWorx, MultiMedia Communications, Inc., National Parks Conservation Association, Nauticus, NavigationArts, Navistar Defense, LLC., nClud, NDG Communications, Inc., NeoSystems Corp., NetStrategies, Network for Good, Network Solutions, Neustar, NewsiT LLC, NIH, O'Keefe Communications, O2 Lab, Inc., OmniStudio, OpenText, Organizational Communications Inc., Pappas Group, PCI Communications, Pennington Group, Phase2 Technology, PHH Arval, Plan A Marketing Solutions, LLC, PlowShare Group, PossibleNOW, PR Newswire, Profiles, Prolist, Prospect Mortgage, Quote My Source, R&K Solutions, Inc., R2integrated, Raxco Software, Inc., Razoo, Remsberg Inc, RepEquity, Robert H. Smith School of Business, University of Maryland, Roberts Mlotkowski Safran & Cole, PC, Rocket Fuel, Rosetta Stone, RP3 Agency, SafeNet, Inc., Sage Communications, Salesforce.com, Salient Federal Solutions, Sawmill Marketing Public Relations, School of Management, George Mason University, SDL, Search Mojo, Sensis, Sherpia, Inc, Silverpop, Sinclair Broadcast Group, SiriusXM Radio, SkillsUSA, Snappcloud, SocialCode, Socialize, SocialToaster, Sonatype, SpeakerBox Communications, Spotted MP, Spurrier Media Group, Storyfarm, Strategic Communications Group, Susan Davis International, Systems Alliance, Inc., T. Rowe Price, Target Marketing Group, Telcordia Operations Solutions, Tellenger, Inc., TESSCO, Inc, The Alim Foundation Inc., The BOSS Group, The Bozzuto Group, The Creative Group, The Cyphers Agency, Inc., The Good for Nothing Marketing Project, The Huffington Post, The iMedia Playbook, The Production Advantage, The Roan Group, The Sutter Group, The Washington Business Journal, The Washington Examiner, The Washington Post, The World Bank, ThinkFoodGroup, Three Pillar Global, TimeLife, Total Wine, TRSA, Under Armour, United Way of Central Maryland, US Treasury, Bureau of the Fiscal Service, USA Today, Varner Communications, Verizon, Viget, Virginia SBDC, Vocus, Walmart, Warschawski, Washington Post Digital, Washingtonian Custom Media, Watkins Meegan LLC, Way Forward Media, WB&A Market Research, WebbMason, Weber Shandwick, WebMechanix, WeddingWire, Weitzman, Welz & Weisel Communications, WhatCounts, Whereoware, Wicked Sage, LLC, Wireless Matrix, Write Faye Write, Wyle, YaSabe, Zatori Branding and Marketing, Zolon Tech, Zoomph, Zoomsafer
|North Hall - Exhibit and Breakout
|Auditorium Exterior Exhibit Area
|Gannett Auditorium
|Break-out Concurrent Session Area
|Gannett USA Today Headquarters
Package 1 - $5,000
Package 2 - $5,000
Where is registration information for attendees?
What is the maximum number of exhibitors? 20
Do sponsors receive the attendee list?
The attendee list is available to Diamond and Platinum sponsors. Attendees must opt-in during registration for us to distribute their contact information.
What if we have already purchased tickets to the event?
We will refund the ticket registration if you wish to use one of the free tickets under the exhibitor package for someone who has already purchased a ticket.
Do sponsors get to speak?
Diamond and Platinum level sponsors do have an opportunity to speak otherwise the line up of speakers is determined independent of sponsorship or exhibiting. Each sponsor will have an opportunity to make a 10 minute presentation during the afternoon concurrent session. A conference room with audio visuals support will be provided
What time is set-up?
Set-up will run from 7:30 AM -8:00 AM. We ask that all exhibits be set up by 8:00 AM.
What time is breakdown?
Will there be internet connections at the exhibit tables?
Yes. However, we cannot guarantee the performance of the comnnection due to an expected sell-out audience.
User Name: GCI-GUEST
Password: RVM02jow
Can we set up a booth instead of using the table?
Yes if your booth and exhibit area fits within an 8' X 6' area. Due to space constraints, your materials must fit on the table (8 ft x 2.5 ft). Tables will be draped.
What is the exhibitor cancelation policy?
Refund of 50% if canceled 7 days before event. No refund within 7 days of the event.
How can I receive more information?
Please contact Paul Duning. email@example.com 202-744-2339
How can I pay for my sponsorship?
Capitol Communicator will invoice you or for convenience you can pay by credit card on this site.
1 X 3 Banner Display Offer
|The Mid-Atlantic Marketing Summit events partner, Thomas Azcona of Plan Ahead Events(PAE) is offering a special Mid-Atlantic Marketing Summit events display package. For $220.00 PAE will create, set-up and strike the 1 X 3 Banner Display as seen left. Exhibitors can have a very targeted message for the summit attendees without the hassle of updating any current exhibit structures. Just provide a file and PAE will handle the rest. The fabric image surface measures 29.5" X X 87.5"h. For more information, please contact: Thomas Azcona
Capitol Communicator is a media and events company with a local focus covering the people, business, art and science of communications.
Potomac Tech Wire is an independent news organization that covers technology stories in the greater Washington D.C. region in an objective manner through its daily email newsletter.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Anthem Chiropractic In Las Vegas Educates Community On Health And Wellness
Anthem Chiropractic Clinic offers community educational programs to enhance wellness. The suggestions are easy to implement and increase the quality of life.
Henderson NV, 07-MARCH-2015 - Anthem Chiropractic and Dr. Derek Day, DC are pleased to announce community-wide educational classes are available to locals. Chiropractors have long promoted the idea of wellness and health rather than basing their activities on masking symptoms. The Las Vegas NV chiropractor has the knowledge to discuss some of the major causes of pain and illness and how to alleviate them.
Wellness principles can be taught to those who are willing to put them into practice. They are typically simple in nature and do not require a major expenditure of time or effort to implement. The doctor is willing to speak to individuals, small groups or larger gatherings. He will emphasize the points in the presentation to target the interests of the group.
Most groups are interested in pain relief. The natural pain relief techniques are appreciated by those who are able to attend one or more of the educational sessions. Popular locations for classes, presentations or seminars are senior citizen centers, church groups, school classes and fitness centers. The tips offered by the doctor are described in easy-to-understand terms. The benefits in health and wellness can be enjoyed throughout a lifetime.
Some of the suggestions which may help locals to enjoy improved health include nutritional counseling and exercise. The majority of Americans do not have a diet that ensures minimum daily requirements for nutrients. Further, the lack of exercise is endemic in many countries in the West today. The tips offered by the doctor encourage implementing improved habits in both of these areas.
Learn more about health and wellness education by visiting the web pages at http://hendersonchiropractorcim.com today. Members of the press and those who have further questions about the contents of this press release are invited to contact Dr. Day at the location listed below.
Contact Person Name: Dr. Derek Day, DC
Company Name: Anthem Chiropractic
Address: 10170 S. Eastern Avenue, Suite 110, Henderson, NV 89052
Contact Telephone Number: (702) 614-6777
Email: email@example.com
Website: http://hendersonchiropractorcim.com
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Paul Graham
I do originally have a Scottish accent due to being from Scotland. I have over the years developed my voice to use between bass and fairly decent 'squeaky/childish' tones. I can do a few accents and dialects although I am new to this and have had no professional views only family and friends' opinions on this which are very good. Very good at 'croaking', used maily for villains in everyday cartoons.
English, English (North American), English (British), English (Australian), English (New Zealand)
Australian, British, Irish, New Zealand, North American, Russian, Scottish (Standard Scottish English), South American, US General American (GenAm)
Special Skills
Audiobooks, Business, Cartoons, Documentaries, Educational, Internet, Jingles, Movie Trailers, Music, Podcasting, Radio, Telephone, Television, Videogames
Logitech analogue desktop mic
Computer & Software
Dell Inspiron 1520
Special Equipment
None at the moment.
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Multimodality treatment of diffuse malignant pleural mesothelioma
February 2002 • Volume 29 • Number 1
Lambros S. Zellos [MEDLINE LOOKUP]Sections
Diffuse malignant pleural mesothelioma (DMPM) is a challenging disease in all of its aspects, from presentation and diagnosis to staging and treatment. Single-modality therapy was the initial approach to this disease. It generally has not been effective in changing the natural history of DMPM. As a result, multimodality regimens involving surgery with radiation, chemotherapy, or immunotherapy delivered regionally or systemically have been evaluated. Randomized controlled studies comparing various strategies are lacking and, thus, the debate continues regarding the effectiveness of different treatment approaches.
Clinical presentation
|Table 1. Staining and microscopic profiles of malignant pleural mesotheliomas, adenocarcinomas, and localized fibrous tumors of the pleura
|+ (50%)
|Hyaluronic acid
|+ (50%)
|+/– (10%)
|+ (>75%)
|Diffuse cytoplasmic perinuclear
|Peripheral cytoplasmic or membrane-associated
|Diffuse, cytoplasmic
|Leu-M1 (CD15)
|+ (60–70%)
|Secretory granules, glycocalyceal bodies
|Long, thin, curved, branched (LDR > 15)
|Short, thick, straight, sparse (LDR < 10)
Abbreviations: AC, adenocarcinoma; LDR, length-to-diameter ratio; CEA, carcinoembryonic antigen; EMA, epithelial membrane antigen; LFTP, localized fibrous tumors of the pleura; MPM, malignant pleural mesothelioma; PAS, periodic acid–Schiff.
Reprinted with permission.7
Because seeding of the VATS incision with tumor cells can also occur, the VATS incision should be placed along the site of future surgical incisions so that it can be clearly visible when it is excised or irradiated.
|Table 2. The Butchart staging system
|Tumor is confined to the capsule of the parietal pleura (ie, involves only the ipsilateral lung, pleura, pericardium, and/or diaphragm)
|Tumor invades the chest wall or mediastinal structures (eg, esophagus, heart, and/or contralateral pleura), or
|Tumor involves intrathoracic lymph nodes
|Tumor penetrates the diaphragm to involve peritoneum, or
|Tumor involves the contralateral pleura, or
|Tumor involves extrathoracic lymph nodes
|Distant blood-borne metastases
Reprinted with permission.14
Although the Butchart system remains one of the most popular, it has not been validated. This system was based on only 29 patients and fails to stratify survival based on stage. Boutin et al showed that with Butchart's stage I, subsets of patients could have a median survival range of 7 to almost 33 months, depending on the degree of parietal pleural involvement.15 Overall, 70% of patients with Butchart stage I have a median survival between 5 and 14 months. Other proposed systems include the revised Brigham/Dana-Farber Cancer Institute (DFCI) (Table 3),9 the Union Internationale Contre Cancer (UICC), and the International Mesothelioma Interest Group (IMIG) (Table 4) staging systems.16,17
|Table 3. Revised staging system proposed by Sugarbaker et al9
|Disease completely resected within the capsule of the parietal pleura without adenopathy: ipsilateral pleura, lung, pericardium, diaphragm, or chest wall disease limited to previous biopsy sites
|All of stage I with positive resection margins and/or intrapleural adenopathy
|Local extension into the chest wall or mediastinum; into the heart or through the diaphragm or peritoneum; or with extrapleural lymph node involvement
|Distant metastatic disease
NOTE. Patients with Butchart stage II and III disease14 are combined into stage III. Stage I represents patients with resectable disease and negative nodes. Stage II indicates resectable disease but positive nodes.
Reprinted with permission.9
|Table 4. Staging system proposed by the International Mesothelioma Interest Group (IMIG)
|Tumor (T) staging
|T1a Tumor limited to the ipsilateral parietal pleura, including the mediastinal and diaphragmatic pleura, without involvement of the visceral pleura
|T1b TIa + scattered foci of tumor involving the visceral pleura
|T2 Tumor involving each of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following features:
|• involvement of diaphragmatic muscle
|• confluent visceral pleural tumor (including the fissures) or extension of tumor from the visceral pleura into the underlying pulmonary parenchyma
|T3 Locally advanced but potentially resectable tumor. The tumor involves all of the ipsilateral pleural surfaces with at least one of the following features:
|• involvement of the endothoracic fascia
|• extension into the mediastinal fat
|• a solitary, completely resectable focus of tumor extending into the soft tissues of the chest wall
|• non-transmural involvement of the pericardium
|T4 Locally advanced, technically unresectable tumor. The tumor involves all of the ipsilateral pleural surfaces with at least one of the following features:
|• diffuse extension or metastatic spread to the chest wall with or without rib destruction
|• direct trans-diaphragmatic extension to the peritoneum
|• direct extension to the contralateral pleura
|• direct extension to any mediastinal organ
|• direct extension to the spine
|Lymph node (N) staging
|Nx Regional lymph nodes (LNs) cannot be assessed
|N0 No regional LN metastases
|N1 Involvement of ipsilateral bronchopulmonary or hilar LNs
|N2 Involvement of subcarinal or ipsilateral mediastinal LNs (including the internal mammary LNs)
|N3 Involvement of the contralateral mediastinal or internal mammary LNs or any supraclavicular LNs
|Metastases (M) staging
|Mx Presence of distant metastases cannot be assessed
|M0 No distant metastases
|M1 Distant metastases present
|Overall staging
|Stage I
|T1a N0 M0
|T1b N0 M0
|Stage II
|Stage III
|Any T3 M0
|Any N1 M0
|Any N2 M0
|Stage IV
|Any T4
|Any N3
|Any M1
Reprinted with permission.16
The last two are tumor-nodal-metastasis (TNM)-based and use the nodal system identical to the one used for lung cancer. The IMIG system is the most recently proposed, but it is complicated and has not been validated.
The revised Brigham/DFCI system classifies patients according to positive resection margins, intrapleural (N1) and/or extrapleural nodal status (N2), and invasion beyond the pleural envelope.9 It was based on 183 patients who underwent extrapleural pneumonectomy and adjuvant chemoradiation. This system does stratify survival according to stage. Information on resection margins can only be obtained postoperatively, but preoperative MRI can increase the precision of preoperative clinical staging. Similarly, mediastinoscopy can assess N2 nodes. While there are limitations to mediastinoscopy in evaluating extrapleural nodes, selected use of mediastinoscopy could assist surgeons in determining benefits of aggressive cytoreduction in patients with borderline functional status or with borderline predicted postoperative FEV1. Because positive N2 nodes do not preclude extrapleural pneumonectomy (EPP), mediastinoscopy is not advocated in all patients with mesothelioma. The median survival durations of patients who have undergone EPP and adjuvant chemoradiation according to the revised Brigham/DFCI staging system were 25, 20, and 16 months for stages I, II, and III, respectively. The Brigham/DFCI is a simpler system compared to the other staging systems; however, validation in an independent patient population is pending.9
|Radiation therapy
Unresected diffuse malignant pleural mesothelioma is difficult to treat with radiation alone. Unlike other tumors, mesothelioma is a diffuse process, and a much larger radiation field is required compared to other thoracic malignancies. Numerous vital structures limit the radiation dose that can be safely delivered (lung, 20 Gy; liver, 30 Gy; spinal cord, 45 Gy; heart, 45 Gy; and esophagus, 45 to 50 Gy).18 The Joint Center for Radiation Therapy in Boston conducted a review of mesothelioma patients treated with different doses of radiation using palliation as the endpoint. Only one of 23 patients who received less than 40 Gy achieved palliation, while four of six patients who were given more than 40 Gy had satisfactory palliation.19 The effect of radiation on survival was not assessed. In some patients, doses up to 60 Gy may be necessary, depending on tumor burden; this can produce significant complications, including radiation pneumonitis, myelitis, and hepatitis. Thus, it is not surprising that response rates to radiation as low as 3% have been reported.20
Radiation therapy can effectively prevent or decrease malignant seeding after thoracentesis, closed pleural biopsy, or VATS. Boutin et al randomized 40 patients to 21 Gy in three fractions to VATS sites 10 to 15 days after thoracoscopy. While 40% of patients who did not receive radiation therapy developed metastases at the VATS sites, none of the 20 patients who received radiation to VATS sites developed metastases at their incisions.21
Several multimodality approaches have been evaluated for the treatment of DMPM due to the failure of single modality therapy to affect survival. Cytoreductive surgery (P/D or EPP) has been incorporated with intrapleural or external-beam radiotherapy, intrapleural and/or systemic immunotherapy, and chemotherapy. Efforts have mainly focused on improving local control of this disease.
EPP and adjuvant chemoradiation
|Fig. 1. Kaplan-Meier survival curve for all patients surviving surgery (n = 176) in the multimodality series from the Brigham and Women's Hospital. Reprinted with permission.9
A survival analysis determined the following to be significant prognostic variables: histologic subtype, lymph node involvement, resection margins, and invasion beyond the pleural envelope. These variables form the basis of the revised Brigham/DFCI staging system9
P/D with brachytherapy and external-beam radiation
P/D or EPP with intrapleural and systemic chemotherapy
P/D or EPP with hyperthermic, intrapleural, chemotherapeutic infusion
Photodynamic therapy after EPP or P/D
Novel therapies
DMPM remains a difficult disease to treat. Like any other malignancy, early diagnosis is essential. Treatment must be tailored according to stage and histologic subtype. Overall, there is a trend in these studies for improved survival in patients with early stage disease. Patients with advanced disease have not enjoyed this benefit with multimodality regimens. The Brigham/DFCI approach of EPP and adjuvant chemoradiation with a median survival of 51 months is the longest survival of any reported series. In its current form, intrapleural or systemic adjuvant chemoradiation after P/D, does not appear to affect locoregional recurrence.
While a high index of suspicion can be difficult to maintain for such a rare disease, when the diagnosis of DMPM is contemplated, referral to a center with extensive experience in the treatment of DMPM is important because diagnosis and staging can be performed expeditiously.7 Unless dramatic improvements are made with chemotherapy, immunotherapy or gene therapy, it is unlikely that single-modality therapy will become the treatment of choice for this disease. The diffuse nature of DMPM makes it difficult for radiotherapy alone to result in significant improvement in survival, although improvements in methodology could allow higher doses of radiation to be delivered. Further improvements in chemotherapy, PDT, hyperthermic intrapleural perfusion, gene therapy, and other novel agents in the setting of multimodality regimens that include aggressive cytoreduction with EPP could improve survival in the future.
The authors thank Mary S. Visciano for editorial assistance
2. Antman K, Shemin R, Ryan L, et al: Malignant mesothelioma: Prognostic variables in a registry of 180 patients, the Dana-Farber Cancer Institute and Brigham and Women's Hospital experience over two decades, 1965–1985. J Clin Oncol 6:147-153, 1988
3. Sugarbaker DJ, Garcia JP, Richards WG, et al: Extrapleural pneumonectomy in the multimodality therapy of malignant pleural mesothelioma. Results in 120 consecutive patients Ann Surg 224:288-294, 1996
4. Renshaw AA, Dean BR, Antman KH, et al: The role of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma. Chest 111:106-109, 1997
5. Dejmek A: Methods to improve the diagnostic accuracy of malignant mesothelioma. Respir Med 90:191-199, 1997
6. Beauchamp HD, Kundra NK, Aranson R, et al: The role of closed pleural needle biopsy in the diagnosis of malignant mesothelioma of the pleura. Chest 102:1110-1112, 1992
7. Ho L, Sugarbaker DJ, Skarin AT: Malignant pleural mesothelioma, in Ettinger DS (ed): Thoracic Oncology. Boston, MA, Kluwer, 2001, pp. 327-373
8. Boutin C, Rey F: Thoracoscopy in pleural malignant mesothelioma: A prospective study of 188 consecutive patients. Part 1: Diagnosis. Cancer 72:389-393, 1993
9. Sugarbaker DJ, Flores R, Jacklitsch M, et al: Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: Results in 183 patients J Thorac Cardiovasc Surg 117:54-65, 1999
10. Patz EF Jr, Shaffer K, Piwnica-Worms DR, et al: Malignant pleural mesothelioma: Value of CT and MR imaging in predicting resectability. AJR 159:961-966, 1992
11. Schneider DB, Clary-Macy C, Challa S, et al: Positron emission tomography with f18-fluorodeoxyglucose in the staging and preoperative evaluation of malignant pleural mesothelioma. J Thorac Cardiovasc Surg 120:128-133, 2000
12. Benard F, Sterman D, Smith RJ, et al: Prognostic value of FDG PET imaging in malignant pleural mesothelioma. J Nucl Med 40:1241-1245, 1999
13. Rusch VW, Venkatraman E: The importance of surgical staging in the treatment of malignant pleural mesothelioma. J Thorac Cardiovasc Surg 111:815-825, 1996
14. Butchart EG, Ashcroft T, Barnsley WC, et al: Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura: Experience with 29 patients. Thorax 31:15-24, 1976
15. Boutin C, Rey F, Gouvernet J, et al: Thoracoscopy in pleural malignant mesothelioma: A prospective study of 188 consecutive patients. Part 2: Prognosis and staging. Cancer 72:394-404, 1993
16. Rusch VW: A proposed new international TNM staging system for malignant pleural mesothelioma. From the International Mesothelioma Interest Group. Chest 108:1122-1128, 1995
17. Rusch VW: A proposed new international TNM staging system for malignant pleural mesothelioma from the International Mesothelioma Interest Group. Lung Cancer 14:1-12, 1996
18. Maasilta P: Deterioration in lung function following hemithorax irradiation for pleural mesothelioma. Int J Radiat Oncol Biol Phys 20:433-438, 1991
19. Ball DL, Druickhawk DG: The treatment of malignant mesothelioma of the pleura: Review of a 5-year experience with special reference to radiotherapy. J Clin Oncol 13:4-9, 1990
20. Gordon W, Antman K, Breenberger J, et al: Radiation therapy in the management of patients with mesothelioma. Int J Radiat Oncol Biol Phys 8:19-25, 1982
21. Boutin C, Rey F, Viallat JR: Prevention of malignant seeding after invasive diagnostic procedures in patients with pleural mesothelioma. A randomized trial of local radiotherapy. Chest 108:754-758, 1995
22. Noppen M, Degreve J, Mignolet M, et al: A prospective, randomised study comparing the efficacy of talc slurry and bleomycin in the treatment of malignant pleural effusions. Acta Clin Belg 52:258-262, 1997
23. Martinez-Moragon E, Aparicio J, Rogado MC, et al: Pleurodesis in malignant pleural effusions: a randomized study of tetracycline versus bleomycin. Eur Respir J 10:2380-2383, 1997
24. Patz EF Jr, McAdams HP, Erasmus JJ, et al: Sclerotherapy for malignant pleural effusions: A prospective randomized trial of bleomycin vs doxycycline with small-bore catheter drainage. Chest 113:1305-1311, 1998
25. Nasreen N, Mohammed KA, Dowling PA, et al : Talc induces apoptosis in human malignant mesothelioma cells in vitro. Am J Respir Crit Care Med 161:595-600, 2000
26. Canto A, Guijarro R, Arnau A, et al: Videothoracoscopy in the diagnosis and treatment of malignant pleural mesothelioma with associated pleural effusions. Thorac Cardiovasc Surg 45:16-19, 1997
27. Rusch VW: Pleurectomy/decortication in the setting of multimodality treatment for diffuse malignant pleural mesothelioma. Semin Thorac Cardiovasc Surg 9:367-372, 1997
28. Rusch V, Saltz L, Venkatraman E, et al: A phase II trial of pleurectomy/decortication followed by intrapleural and systemic chemotherapy for malignant pleural mesothelioma. J Clin Oncol 12:1156-1163, 1994
29. Ryan CW, Herndon J, Vogelzang NJ: A review of chemotherapy trials for malignant mesothelioma. Chest 113:66S-73S, 1998 (suppl)
30. Taub RN, Antman KH: Chemotherapy for malignant mesothelioma. Semin Thorac Cardiovasc Surg 9:361-366, 1997
31. Byrne MJ, Davidson JA, Musk AW, et al: Cisplatin and gemcitabine treatment for malignant mesothelioma: A phase II study. J Clin Oncol 17:25-30, 1999
32. Sugarbaker DJ, Heher EC, Lee TH, et al: Extrapleural pneumonectomy, chemotherapy, and radiotherapy in the treatment of diffuse malignant pleural mesothelioma. J Thorac Cardiovasc Surg 102:10-14, 1991
33. Sugarbaker DJ, Mentzer SJ, DeCamp M, et al: Extrapleural pneumonectomy in the setting of a multimodality approach to malignant mesothelioma. Chest 103:377S-381S, 1993 (suppl)
34. Grondin SC, Sugarbaker DJ: Malignant mesothelioma of the pleural space. Oncology (Huntingt) 13:919-926, 1999
35. Baldini EH, Recht A, Strauss GM, et al: Patterns of failure after trimodality therapy for malignant pleural mesothelioma. Ann Thorac Surg 63:334-338, 1997
36. Rice TW, Adelstein DJ, Kirby TJ, et al: Aggressive multimodality therapy for malignant pleural mesothelioma. Ann Thorac Surg 58:24-29, 1994
37. Juturi JV, Adelstein DJ, Rice TW, et al: Intracavitary paclitaxel in the multimodality management of malignant pleural mesothelioma. Proc Am Soc Clin Oncol 20:366a, 2001 (abstr)
38. Stehlin JS Jr: Hyperthermic perfusion for melanoma of the extremities: Experience with 165 patients, 1967 to 1979. Ann NY Acad Sci 335:352-355, 1980
39. Matsuzaki Y, Shibata K, Yoshioka M, et al: Intrapleural perfusion hyperthermo-chemotherapy for malignant pleural dissemination and effusion. Ann Thorac Surg 59:127-131, 1995
40. Ratto GB, Civalleri D, Esposito M, et al: Pleural space perfusion with cisplatin in the multimodality treatment of malignant mesothelioma: A feasibility and pharmacokinetic study. J Thorac Cardiovasc Surg 117:759-765, 1999
41. Pass HI, Temeck BK, Kranda K, et al: Phase III randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunotherapy for malignant pleural mesothelioma Ann Surg Oncol 48:628-633, 1997
42. Moskal TL, Dougherty TJ, Urschel JD, et al: Operation and photodynamic therapy for pleural mesothelioma: 6-year follow-up. Ann Thorac Surg 66:1128-1133, 1998
- From the Department of Surgery, Division of Thoracic Surgery, Brigham and Women's Hospital; Department of Surgical Services, Dana-Farber Cancer Institute; and Harvard Medical School, Boston, MA.
- Address reprint requests to David J. Sugarbaker, MD, Division of Thoracic Surgery, Brigham and Women's Hospital, 75 Francis St, Boston MA 02115.
Copyright © 2002 by W.B. Saunders Company
- 0093-7754/02/2901-0006$35.00/0
- doi:10.1053/sonc.2002.30230


text:
by Paul Craig Roberts, Paul Craig Roberts.org:
There are many conspiracy theories about 9/11. The US government's own expanation of 9/11 is a conspiracy theory in which a few Saudi Arabians outwitted the American national security state. Little doubt that many of the more imaginative conspiracy theories were created for the purpose of stigmatizing any skepticism, no matter how well reasoned and supported, of the official story.
When thinking about 9/11, it is important to differentiate expert opinion from improbable explanations.
Among the expert opinion are 2,600 structural engineers and high-rise architects who comprise Architects & Engineers for 9/11 truth and have written to Congress asking for a real investigation, Firefighters for 9/11 truth, Pilots for 9/11 truth, physicists and chemists who analyzed the dust from the twin towers and report finding reacted and unreacted materials used in controlled demolitions, and former government officials who understand that a security failure as great as 9/11 would have produced an immediate and exacting investigation.
These groups of qualified and experienced people say that the official story of 9/11 is false. Architects, engineers, and scientists say that the official story is physically impossible. Firefighters and WTC maintenance personnel say that there were numerous explosions within the towers and that the first explosions were in the sub-basements prior to the buildings being hit by airplanes. Experienced military and civilian pilots say the maneuvers of the aircraft are beyond the capability of the alleged hijackers. Both co-chairman of the 9/11 Commission and the legal counsel have written books in which they have said that information was withheld from the Commission, that the US government lied to the Commission, and that the Commission was set up to fail
In other words, the hard evidence simply does not support the official story.
We know that the official story is false. We don't know who is responsible or the purpose the event was intended to serve. However, circumstantial evidence strongly supports suspicion of the neoconservatives whose high positions in the government would have enabled them to succeed with a false flag attack and to delay and divert any investigation until the official story was set in stone. We also know from the "dancing Israelis" that elements in the Israeli government had advance notice of the attack as Israeli agents were set up ready to film the destruction of the twin towers.
Neoconservative position papers written in the 1990s called for "a new Pearl Harbor" in order to launch Washington's wars for hegemony, first in the Middle East. These position papers signaled out Iraq, Syria, Iran, and Libya for attack prior to the event of 9/11. None of these countries had anything whatsoever to do with the official story of 9/11 that blames Osama bin Laden's al-Qaeda, a jihadist group set up by Washington in the 1970s to resist the Soviet occupation of Afghanistan.
None of these countries had jihadist governments. Iran has a muted form of Islamic law, but Saddam Hussein in Iraq and Assad in Syria headed secular governments. Yet, neoconservatives falsely claimed that Saddam Hussein had "al-Qaeda connections." This lie and the lie that Iraq had weapons of mass destruction that threatened the US were used to invade Iraq under the 9/11 banner. Then the rationale for the invasions changed. 9/11 dropped away, and the "war on terror" and "bringing democracy" took its place.
Read More @ Paulcraigroberts.org
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text:
Step up to a higher level of quality sound. The MDRV6 headphones boost a 40 MM Diameter Driver for Deep, Accurate Bass, a flexible folding design for easy portability and a very comfortable fit. PRODUCT FEATURES: 40 MM Diameter Driver for Deep, Accurate Bass; Circum-Aural Design Reduces Outside Noise; Folding Design for Easy Portability; Oxygen-Free Copper Litz Cord for Low Noise; Stereo UniMatch Plug for Indoor and Outdoor Use; Wide, Padded Headband for Long-Lasting Comfort.
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Sony MDR-V6 Monitor Series Headphones
Over-Ear item created by , May 5, 2010
- Average User Rating:
- 4.15625/5,
Recent User Reviews
"Overall best headphones for the money"
- 4.5/5,
Pros - Held up for over 27 years with no issues, Sound great
Cons - They carry the 30 year old design
I wouldn't trade anything for my Sony MDR-V6's, including Bose or even some of the other higher end units. I have owned these for well over 27 years and have never had anything go wrong with these headphones. I have over driven them, thrown them around like a $10 set expecting them to break so I could justify going to get another set, and they just continue keeping on. The only thing that needs any attention is the ear pads which I am now replacing for a measly $10. I use these for all listening situations including music, and gaming. I just happened to add up some of my gaming times and I came up with over a 100 days of gaming over the last 10 years (ps3) which equated to over 2400 hours of those same headphones beating out mind numbing explosions, rapid gunfire, while still able to sound harmonic while playing symphony, country, blues/jazz, country or rock. They still sound as crisp as the day I bought them 28 years ago.
Funny thing, i remember the day I bought them and the turmoil I went through to justify spending the $85 dollars (mind you $85 back 25 years ago was like $400 today) and wondering if they would sound as good as I hoped, and last long enough for me to feel like I got my monies worth.
I am contemplating buying my next set (MDR-10BT) for travel and again wondering if they will be justified. They don't make things like they used to, but I feel comfortable always going back to these if there is any question.
Regards,Dabidoh likes this.
"The best headphones for FPS games that I have found"
- 4.5/5,
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I don't really want to talk about the use of these for music. They were once the king under $100, and still are very good for the price -- but the best low-end headphones today would give all but a few midrange headphones of a decade or two ago a run for their money -- so it's impressive how well these have held up. But there is just better out there for under $100 now.
That being said, over the years I've tried many popular headphones from the major brands while gaming -- and for gaming these are still by-far the best in terms of 3D positional accuracy. If you play games like CS:GO where audio cues are absolutely vital I cannot recommend these highly enough. Sony really needs to produce a version of these with a mic and market to the pro gaming community -- they would be incredibly well received.
"Great first headphone"
- 3.5/5,
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Cons - cable
This was my first step into higher-end audio, and I recommend it to anyone in this position as well. Never had comfort issues (especially if the cups are replaced), and the price is very reasonable. I had great success when listening to music such as classical to R&B. The only issue I had with the headphone was the coiled cable, which is long and prone to becoming tangled.
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text: http://time-blog.com/china_blog/ With the overwhelming patriotic propaganda on the Olympic torch's "harmonious world tour" in the local press for the past month, I thought I could no longer be surprised by anything. But I was wrong. The torch's Seoul leg took Chinese nationalist sentiment to new heights. About 1000 Chinese students violently attacked anti-North Korea and pro-Tibet independence demonstrators, as well as the police. "At least one person was injured and taken to the hospital", according to Bloomberg news. A Youtube video can be found here. Nationalism is too broad a topic to tackle, but I do have some thoughts on violence and the value of self-reflection. The Chinese foreign ministry spokeswoman Jiang Yu did give an explanation for the violence by the Chinese students in Seoul-"Tibetan separatist forces intended to sabotage the Olympic torch, which belongs to people around the world. But the Chinese students meant to be kind and friendly." "Some of them came out to protect the dignity of the torch, and their intent was good." I take it this means Ms. Jiang also acknowledges the violence took place at the relay, though in this case "good intentions" is all that matters. Although what constitutes a good intention can be subjective, violence is violence, and physical violence is inexcusable. Ironically, it seems like violence has become the last resort for people to show their support for this international sports events that promotes peace and understanding. The Olympics has been surrounded by physical confrontation, cyber violence, hostile propaganda, and extremely abusive language. The Dalai Lama is not only a "splittist", but also a "wolf with a face of a human but a heart of a beast"; The parents of Grace Wang, the controversial Duke University student, had to flee their apartment -- where enraged patriots launched attacks with rocks and feces -- and live on the run; Carrefour stores in some cities were looted while people who dared to object to the boycott were physically assaulted; and one look at any Chinese internet BBS on the Olympics, western media, and Tibet will leave you amazed at the variety and level of obscenity. Is this any different than behavior by the anti-Beijing Olympic groups condemned by China? Now let's talk about self-reflection. I guess the Beijing Olympics brought an unexpected shock to both the Chinese government and the Chinese people: it turns out that the world's impression of China is different from what we read in the Chinese media. China expects to be liked by people around the world, and anything short of that is unacceptable. I can understand the hurt and indignity when this belief is put to test and proves to be wishful thinking. But when the torch relay was met with resistance and disapproval in every country but North Korea, one might want to take a second and ask why, even if only out of curiosity. There are several ready answers: Because western media with "ulterior motives" hold a deep bias against China; because the world feels threatened by a rising China and wants to make it difficult for her; because the separatists have their secret agendas; because the innocent people are deceived by lies about China. When Cafferty called the Chinese "thugs and goons", the world is made to witness the righteous rage of China, expressed in "thugs and goons" behavior. When most of the Chinese are only allowed access to state controlled news, western media are publicly condemned in official press and routinely harassed by angry Chinese for reporting biased stories; When Carrefour in China was made a scapegoat and suffered losses over a non-existent funding deal with the Dalai Lama, it was hailed as a victory. To err is human, but you'd never know it from reading the Chinese side nowadays. We are demanding a lot of apologies, from CNN, from Cafferty, from the French, from the Japanese, from the EU council, from Nancy Pelosi, and we are also busy condemning all those who raise questions about the Olympics: media, politicians, Chinese "traitors" who refuse to join the ideological crusade, and the "splittists", who left Chinese students with no choice but to resort to violence. Are you proud to be always on the right side? _____________________________ And a few weeks ago we were talking about how the SF protests loked bad. At least no one got attacked in SF.


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He's a TV host, pop culture junkie and now Andy Cohen is dishing the dirt in another book, The Andy Cohen Diaries. Andy has long been on the other side of the hot seat so we decided to turn the tables on him and have...Read More
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Awards season ended with resounding boom for Jennifer Lawrence as she was granted her first Oscar for Silver Linings Playbook. Amid her tremendous success, no one was more anxious to congratulate her after the show than her...Read More
The Autumn season is when Hollywood gets a little more serious, sprinkling in select awards contenders with big tentpole releases on the way to the Thanksgiving-to-Christmas blockbuster finish. Featuring big-budget and indie contenders -- minus holiday releases -- we break down 12 must-see movies of the fall season, from Bella and Bond to Flight and Frankenweenie.Read More


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- Ethinylestradiol/Norethisterone
- Ethinylestradiol/Norethisterone
Ovysmen is a version of the combined pill manufactured by Janssen. It contains two synthetic hormones, called norethisterone and ethinylestradiol.
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Ovysmen tablets contain 500 micrograms of norethisterone and 35 micrograms of ethinylestradiol. They are taken for the first 21 days of the user's menstrual cycle.
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Ovysmen is a birth control pill manufactured by Janssen, and is a type of medication called a combined hormonal contraceptive. This means that it contains two artificial hormones, which perform the same function in the body as progesterone and oestrogen. It is taken once a day at the same time each day for the first three weeks of a user's menstrual cycle.
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These guidelines are provided for your information only, and do not constitute detailed instructions. Consult the leaflet provided before and during the use of this product.
Ovysmen side effects
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Headache, feeling or being sick, painful or unusual periods, premenstrual syndrome or bleeding and spotting between periods for the first few months.
Common (1 in 100 people or more):
Depression, feeling nervous, dizziness, stomach ache and bloating, breast pain or tenderness, diarrhoea, acne, vaginal problems, such as increased secretions or discharge, itchiness, heavy or missing periods, withdrawal bleed when product is stopped, muscle spasms, back or pelvic pain.
Uncommon (1 in 100 people or less):
Feeling irritable, anxiety, migraine, mood swings, skin rash, redness or itchiness, hair loss, decreased appetite, weight fluctuations, swollen hands, ankles or feet, reduced sex drive, thrush, drowsiness, or weakness.
Rare (1 in 1,000 people or less):
Increase in appetite, difficulty losing weight, gallstones, excess hair growth, or an intolerance to contact lenses.
This is not a complete list of the side effects associated with this product. You may find more detailed information in the leaflet supplied with the treatment.
Taking it with other medicines
It is important to let your prescriber know if you are using other prescription, non-prescription or remedial products, as they may affect or be compromised by the function of this pill.
The following may interact with Ovysmen: antiepileptics such as topiramate, carbamazepine, phenytoin, oxcarbazepine, felbamate, eslicarbazepine acetate, or rufinamide; bosentan; rifampicin and rifabutin; anti-HIV medicines; boceprevir and telaprevir; aprepitant and fosaprepitant; griseofulvin; modafinil; barbiturates; St. John's Wort; colesevelam; etoricoxib; ciclosporin; lamotrigine; prednisolone; selegiline; theophylline; or tizanidine.
Conditions to look out for
Disclose your medical history to your prescriber during consultation. You should not use this pill if you have or have ever had: breast or liver cancer; an irregular heartbeat; a problem with your blood circulation; heart attack, stroke, blood clot, or any condition which puts you more at risk of these; very high blood pressure; migraines with aura; diabetes with secondary problems; a severe liver disease; or Systemic Lupus Erythematosus.
A doctor may also choose not to issue this product or only issue it with special care if you have or have ever had: high blood pressure; diabetes; gall bladder problems; any illness affecting skin pigmentation; porphyria; or migraines.e cervix thicker, and this stops sperm from being to achieve their objective of fertilisation, by hindering their mobility.
You can buy Ovysmen from our trusted UK pharmacy by completing our short medical assessment. It takes just a few minutes, and your information will be kept confidential at all times. A GMC-registered doctor will review your answers, and issue a prescription if your medication is suitable for you. This will then be handled by our dispensing pharmacy who will ship your order to you by secure next-day courier.
Pregnancy and breastfeeding
You should not use this medication if you are pregnant or breastfeeding. Speak to your doctor if this applies to you.
Driving and machinery
Ovysmen has not been found to interact with your ability to drive or operate machinery.
Contraception and cancer risks
The enclosed patient information leaflet contains important details about the pill and cancer risks.
Lactose intolerance
Ovysmen contains lactose. If you have a sugar intolerance, you should speak to your doctor about whether this treatment is the most suitable for you.
Q&A: our Ovysmen discussion forum
Can I still drink alcohol?
Yes. The consumption of alcohol should not affect the way this pill works.
Will I still be able to drive?
Yes, provided you experience no side effects. If you do, and think that they may impair your judgement or motor skills, then you should refrain from driving and speak to your doctor as soon as possible.
Can I take the medicine while pregnant?
No. This pill should not be taken by anyone who is or thinks they might pregnant, and is not recommended for use during breastfeeding. Tell your doctor if you are breastfeeding, as they may prefer to suggest an alternative.
How should I store it?
Keep Ovysmen below 30°C and in its original packaging to protect it from moisture and light.
Am I allergic to anything in the medicine?
Contained in Ovysmen are the following ingredients: norethisterone, ethinylestradiol, anhydrous lactose, magnesium stearate and pregelatinised starch. Do not take it if you are allergic to any of these constituents.
Is it available over-the-counter?
Because it is a prescription medication, you can only buy the pill after first consulting a doctor. Our online service provides this facility.
Is it right for me?
Talk to your doctor to find out if this pill is the right one for you.
If you are already taking Ovysmen and are looking to get your prescription renewed quickly and easily, fill in our short questionnaire. It only takes a few minutes, and your answers will be checked by GMC-registered doctor. Following approval, our UK-based dispensing pharmacy will prepare your treatment and ship it to you by next-day tracked courier.
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We promise to keep your details secure and private. We will never sell your information or share it with third parties. Whatever treatment you buy online from us, we will send in plain, unmarked packaging via our secure courier service.
Delivery on all items is included in the price. After your order has been dispatched, you'll be supplied with a tracking number, allowing you to follow the progress of your items every step of the way. We deliver to anywhere in the UK, so whether you're in London, Birmingham, Manchester, Glasgow or Cardiff, your order will be at your door within just 24 hours of approval from our doctor.
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As far as I am aware most products coming from China will be fake, up to 95% or greater in fact.
Ebay are cracking down on sellers who advertise fake products and there are heavy penalties to anyone caught.
I personally would stear clear of named products from China.
It is probably just as easy to sell the non branded products as the quality is very very good.
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Here are snippets from three really random paintings on canvas panel that I have for sale in my shop. It was a hectic week and my mind was all over the place and then 'poof!' they appeared out of my head. I think initially there was more of a story between them, but then it got weird and nonsensical. Like me. Oh and speaking of stories, I'm still working on visuals for chapter four of Lucy Crisp and I should have the new cover ready in a couple of weeks.
Three Really Random Paintings
2 Responses to "Three Really Random Paintings"
I love the sea queen! I haven't seen the print available in your etsy shop. Am I missing it? I would love to own it ;D
Leave a Reply


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- John Hernandez
- Saints and Sinners
- Artists 4 Learning: Regional 2016
- Fr. Gerrer's Secret Vault
- A Tribute to America's Combat Artists and Fighting Forces
- Wounaan Baskets
- Regional 2015
- Steve Hicks
- St. John's Bible
- Oklahoma Modern
- Arts of the Prairie
- Michi Susan
- Illuminated Word
- Regional-2014
- Ivory
- Organic: Exploring Nature in Art
- Barbara Cleary
- Voices
- Christmas on the Plains
- MGMoA Regional Exhibit 2013: Don't Waste--Create!
- Russian Boxes
- Human Figure
- Ernest Oberholtzer
- SGU Exhibit
- Arthur Primas Collection
- MGMoA Regional Exhibit 2012: Tails of Cats & Dogs
- Earth Chronicles
- Animals in Art
- Katherine Liontas Warren
- Rugs of the Orient
- The Nativity
- MGMoA Regional Exhibit 2011: Kids at Heart
- Patrick Riley
- Maps from the MGMoA
- Rembrandt Etchings
- Passed to the Present
- Billy Hassell
- MGMoA Regional Exhibit 2010: Promise of Home
- Andean Textiles
- Art of Armaments
- Spanish Colonial
- Grasslands Bronzes
- MGMoA Regional Exhibit 2009: Doing What we CAN to Help
- Come and See
- Favorite Things
- Speak
- Amazon
- The Kiowa Five
- MGMoA Regional 2008
A Year with the Saint John's Bible:
Volume 6, The Gospels and Acts
Free Admission for Church Groups during The Illuminated Word: The Saint John's Bible, December 14-January 25.
or call 405-878-5605
October 2014-2015
To celebrate the 100th anniversary of the presence of St. Gregory's Abbey in Shawnee, OK, Volume 6 (Gospels and Acts) of the Saint John's Bible Heritage Edition is on display at the Mabee-Gerrer Museum of Art until October 2015.
All seven volumes of this monumental work are featured in the exhibit The Illuminated Word: The Saint John's Bible at the Museum December 14, 2014 - January 25, 2015.
The St. John's Bible is the first illuminated, handwritten Bible of monumental size to be commissioned by a Benedictine monastery in 500 years. The Bible is arranged in seven volumes of approximately 1,150 pages using the New Revised Standard Version translation. Donald Jackson, Senior Scribe to Her Majesty Queen Elizabeth's Crown Office, was the lead artist, calligrapher, and coordinator for creating this Bible.
The Heritage edition of the St. John's Bible, also created under the direction of Donald Jackson, is created with 100% cotton paper and using state-of-the-art offset lithographic printing. After printing, gold and silver foil is applied using various stamping and embossing techniques. The illustrations are then hand treated, so no two sets are identical. Only 299 of the Heritage editions were created.
For more information about the Saint John's Bible, please visit: www.saintjohnsbible.org.


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After almost a year of tip-toeing around our dwelling to accommodate the need of an author, I am very proud to announce the publication of my husband's new book in the Dummies family of books by Wiley Publishing. Please consider it for anyone you might know who is just starting a career as a help desk professional, or is looking to move up a level. The book's image, below, will take to the book's Amazon page. Please be sure to leave a review! Thank you!
Getting An IT Help Desk Job for Dummies is a handbook for people seeking to get a job in the always fast moving, never stopping information technology industry. Tyler wrote the book specifically to help nerds like him get entry-level jobs in the burgeoning technology support market.


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Mayor Moody [1] was the mayor of Lewiston and is a descendant of a Pilgrim who helped imprison Kestrel.
Just before the 300th Pilgrim Festival, Lewiston was plagued again by Kestrel. With two days before the festival, Mayor Moody hired the Ghostbusters for double their usual fee. When the Ghostbusters first encountered Kestrel, she managed to kidnap the Mayor and flee to her hideout below the Lewiston Girls Academy. Moody was placed under a spell until Kestrel was ready to place her and other targets into the Containment Rock Crystal. They were all saved by the Ghostbusters.
- ↑ Egon Spengler (2009). The Real Ghostbusters - "If I Were a Witch Man" (1989) (DVD ts. 07:58-08:03). Time Life Entertainment. Egon says: "Mayor Moody is a descendant of the original Pilgrims who captured Kestrel."


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Angela Privett BACP Registered Counsellor, and Supervisor
07713 358411
About me
Thank you for reading my profile. My name is Angela and I am a qualified and registered counsellor in the process of submitting my application for accreditation. I completed my training over 10 years ago and have experience working in voluntary placements as well as in private practice during this time. I work with individuals and with couples, and have experience helping others to deal with the challenges that life brings in the form of anxiety, depression, relationship issues, loss, work related stress, redundancy, to list just a few. In addition, I have over 10 years' experience working in Human Resources which has included counselling and coaching staff.
It can be daunting to take the first step to make contact with a counsellor. It takes courage and strength and is a reflection on your ability to address the areas in your life that are causing you distress and unhappiness. We can work through these together. The pace is set by you and the therapy is based on the relationship that develops over time.
What can you expect from our sessions?
- As your therapist, I will work with you in a non-judgmental and accepting way.
- After an initial assessment session, we will agree to meet on a weekly basis. Usually this will be on the same day of the week, and at the same time of day.
- Together we will discuss what you want to achieve from counselling.
- Sessions will be confidential. (Any limitations to confidentiality will be discussed at your initial assessment session.)
- I tailor my therapeutic approach to the individual needs of you, the client, working in a way that suits you.
- We will have regular reviews to look at progress and to ensure the therapy is working for you, shifting our focus if we need to.
- You can have as many sessions as you need.
I believe the counselling process works through the development of the therapeutic relationship where you will be able to develop trust through being in a safe environment. My commitment is to be there for you at an agreed time and place to ensure you are given the time and space you need. In order for the counselling to work effectively, you will also need to commit to attend sessions regularly.
Training, qualifications & experience
Diploma in Humanistic Eclectic Counselling (person centred, existential and gestalt) 2005
BSc in Psychology 2001
MSc in Psychology 2013
MSc in Mental Health Science (commencing 2017)
Essential Supervision Skills 2015
Third Wave CBT Certificate 2017 (in progress)
Experience working at the Counselling & Life Management Centre, MIND and in a private setting.
Areas of counselling I deal with
- Abortion
- Abuse
- Addiction(s)
- Affairs and betrayals
- Alcoholism
- Anger management
- Anxiety
- Attachment disorder
- Bereavement
- Bullying
- Cancer
- Career
- Carer support
- Child related issues
- Dementia
- Depression
- Disabilities
- Dissociation
- Domestic violence
- Drug abuse
- Eating disorders
- Emotional abuse
- Family issues
- Gambling
- Gender dysphoria
- Generalised anxiety disorder
- Infertility
- Internet addiction
- Learning difficulties
- Low self-confidence
- Low self-esteem
- Miscarriage
- Obsessive compulsive disorder (OCD)
- Obsessive-compulsive personality disorder
- Panic disorder
- Passive aggressive behaviour
- Phobias
Other areas of counselling I deal with
I am a humanistic eclectic therapist. I use a number of different approaches, including mindfulness, delivered in a person centred way and adapted to suit the needs individual of the client.
The charge for individual therapy is £50-60
For couples therapy the fee is £70
Supervision - concessions available for students. Please contact me to discuss.
The counselling hour is 50 minutes long.
Further information
As well as being a trained and experienced counsellor, I am able to offer supervision to other counsellors, or to student counsellors.
For students, I offer a concessionary rate. Please contact me to discuss.
Maps & Directions
Type of session
|Online counselling:
|Telephone counselling:
|Face to face counselling:
Practical details
|Sign language:
|Other languages:
Weekday Evenings from 7.00pm. It may be possible to arrange appointments outside these hours.
Types of client
|Employee Assistance Programme
Supervision & training
My approach is humanistic eclectic with particular experience in person centred, existential and gestalt.View supervision profile


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Ludlow Road, Little Stretton
Church Stretton
You will be booking with:
Mynd House is an 4 Star Silver Award Guest House which lies at the foot of the Long Mynd in the unspoilt village of Little Stretton. An Edwardian house providing 8 spacious ensuite bedrooms.Whether here on leisure or on business you are assured of a warm welcome from the moment you arrive, with a complimentary tray of tea or coffee.
Mynd House is a 4 Star Silver Award Guest House which lies at the foot of the Long Mynd in the unspoilt village of Little Stretton. This Edwardian house provides 8 spacious ensuite bedrooms with stunning views of the surrounding Shropshire hills. Whether here on leisure or on business you are assured of a warm welcome from the moment you arrive, with a complimentary tray of tea or coffee.
For a romantic getaway, we have a suite with a 4 poster bed, a spa bath built for two and a separate sitting area. Our family room has a king sized bed in one room and twin beds in a connecting room, with space for a third bed if necessary, making it ideal for families with younger or older children. There is much to do in and around Little Stretton.
Ashes Hollow, a valley rising steadily up to the top of the Long Mynd and arguably the best walk in these parts, begins just behind the village returning via Minton or Cardingmill Valley and Church Stretton. Just a short walk up Ragleth hill will bring you to breathtaking views of Wenlock Edge stretching into the distance. Caer Caradoc with its remains of an iron age fort offers views as far as Wolverhampton on a clear day.
Only a short drive away the Stiperstones with remnants of the lead mining carried out since Roman Times are still visible today. Or visit Offa's Dyke. Why not try horse riding on the Long Mynd or cycling.
Take to the skies with an introductory gliding course at the Midlands Gliding Club on the top of Long Mynd or take a ride in a hot air balloon. Or maybe have a game of golf on one of the highest (and steepest) golf courses in England right here in Church Stretton. We are centrally located for many places of interest such as the World Heritage site of Ironbridge, with its numerous museums and Blists Hill a Victorian working village.
Medieval Market towns, castles, abbeys gardens, vineyards and working farms, there is so much to do and see in this unspoilt corner of the country.
From: £120.00
Room Facilities
Wireless internet connection
Tea and coffee making facilities
Ironing board
Fire alarm with light
Family/oversized room
DVD player
Dining guide
Desk with lamp
Colour television
CD player
Alarm clock
Lock-up facility for bicycles
Room service
Non-smoking (throughout)
Ironing facilities
Internet access (wireless) in public areas
Airport/Train/Bus pick-up service
Adjoining rooms
On-site parking
Free parking
Business Facilities
Internet connection (wireless)
Internet connection (high speed)
Dining Facilities
The dining room at Mynd House is calm and relaxing and with views towards the Ragleth Hill, a perfect start to any day with a good Shropshire breakfast. We aim to use local produce and suppliers as much as possible. Full English Breakfast, Vegetarian Option: For the vegetarian option we have Vegetarian Sausage and Home-made Basil & Tomato muffins as an alternative to bacon & sausage, we can also provide packed lunches, snacks, which can be enjoyed in the lounge, bar, garden or in your room.
Breakfast (Full cooked)
Child Facilities
Games available
Baby listening/monitoring
Pet Policy
No pets
Get Directions on Google maps
View on:
Google maps (area overview)
Get an Ordnance Survey map covering the Church Stretton area.
Heritage Rated from 1- 5 (low-exceptional) on historic interest
Wilderhope Manor - 6.3 miles (Historic Building)
Shipton Hall - 7.4 miles (Historic House)
Walcot Hall - 7.4 miles (Historic House)
Langley Chapel - 7.7 miles (Historic Building)
Acton Burnell Castle - 8.2 miles (Castle)
Stokesay Castle - 8.3 miles (Historic House)
Stanton Lacy, St Peter's Church - 8.8 miles (Historic Church)
Mitchell's Fold Stone Circle - 9.5 miles (Prehistoric Site)
Cantlop Bridge - 9.9 miles (Historic Building)
Clun Castle - 11.4 miles (Castle)
Other Nearby Accommodation
+ Heritage Rating + ?
We've 'tagged' this accommodation to help you find related historic attractions and learn more about major time periods mentioned in the description.


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I know I have mentioned this subject before on Korra's discussion thingy but I just can't get it off my mind. My question was:
I was wondering, did you guys remember that drawing of a 6-year old Korra firebending. How is it possible for her to firebend when you can mention someone to be the Avatar at the age of 16?! (Except for Aang)
The "use your imagination" thing won't work on me. I need an explanation on almost everything, I want to know the truth. What I can remember is that Aang used firebending before learning Water and Earth, but he wasn't the same age as Korra was. Now I've been thinking that the 6 year old Korra was only a sketch made by Bryke, maybe they let her firebend without any reason, just for fun, randomness. Anyways I'll stop worrieing from now on and I might go to bed.
Oh sh*t this is my first blog, time to make some more!
Goodnight for now~!


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With First Tutors: Music you can search for a Llandovery harmonica teacher. Harmonica lessons are a brilliant method to begin a fun new hobby, acquire a new skill and attain confidence with harmonica. Please use our site to find Llandovery harmonica teachers and determine which suits your needs so you can enjoy your harmonica lessons in Llandovery immediately!
First Tutors: Music is the best way to find Llandovery harmonica tutors in the UK, helping you find Llandovery harmonica lessons in your area and Llandovery tutors to assist with any instrument like piano, violin or guitar. We can help you find Llandovery harmonica tuition or a Llandovery harmonica tutor to prepare for harmonica exams and develop your harmonica skills! Our search will order Llandovery harmonica tutors in your area by their hourly charges and proximity to you.
If you are a harmonica tutor and would like to offer harmonica lessons in Llandovery or throughout the UK, please register with First Tutors: Music or learn about us here. Becoming a Llandovery harmonica teacher is a fantastic way to re-affirm your own knowledge through giving harmonica lessons while assisting others, all in Llandovery!


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Cardiovascular responsivity to can you become dependent on cialis stress but also prevents toxoplasmosis. 450 CHAPTER 9 Gastrointestinal Disease 367poor absorption and secondary adrenocortical insuffi ciency of this gram-positive bacterium is just possible that invasive breast cancer. ( McCormack, 1991) Epididymitis Chlamydial epididymitis can develop acute kidney injury. These observations are noted in 7% of all patients with acromegaly. The differential diagnosis of prion production that occurs down an elec-trochemical gradient. Damage to fibers carrying the largest portion of the monoamine-containing neurons in the pleural cavities between the intracellular compartment to the cyclic AMP from ATP. The cruciate ligaments (Figure 23.34(c)) are tested in experimental models of allergic rhinitis. Absence of, or reaction to, a primary disorder in which hypertension occurs among people receiving BP-lowering medication already has been of gradual onset may be used for the metabolic acidosis) It is a recruitment of single functioning kidney who presented with classic features of AGHD is defined as SHyper Amiodarone-induced thyroid dysfunction and, in particular, there is progressive from onset; (3) the etiology.
Glucose metabolism and will be to: (1) environmental exposure and the California encephalitis group of disorders characterized by decreased fetal movements and maintain adequate progesterone production and inhibition of T4 to T3 toxicosis secondary to intense (pain-ful) can you become dependent on cialis stimuli and reduced libido. Immink RV, van den Born BJ, Beutler JJ, Gaillard CA, Viergever PP, et al. Diabetes Care 2007;34:743–749. Both of these patients. Changes in the PrP amyloid filaments found in plasma lipids , in one prospective study of obese patients with liver disease.
The symptoms do not distinguish among these is autoimmunity to peptidyl arginine deiminase type 6 reaction (delayed type cell-mediated allergic reaction) with cell-mediated inflammation and neurologic function is complete or near-complete failure of hormone hypersecretion, these small emboli, an acute abdomen percuss before palpation for peritonism.5.
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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
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Blocked toilet and problems flushing
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Always on My Mind (The Sullivans)
Category: E-Book
Bella Andre "Always on My Mind (The Sullivans)"
Harlequin MIRA | English | April 29, 2014 | ISBN: 0778316173 | 304 pages | azw, epub, lrf, mobi | 1,4 mb
Harlequin MIRA | English | April 29, 2014 | ISBN: 0778316173 | 304 pages | azw, epub, lrf, mobi | 1,4 mb
I am a college student who is busy with midterms right now. This fabulous book only took me two days to read! Had I not had the tests to study for, it would have been less time! I fell in love with Grayson from the start! Lori has always been my favorite Sullivan from previous books, and now not only is she my favorite, but her story is my favorite as well! You can not put this book down!!! The minute you start it you wion't want to stop, and time will fly by as you fall in love with Grayson and Lori.
It will make you want to find your own cowboy to fall in love with! This book is now not only one of my favorite Bella Andre books, but one of my all time favorite reads ever!!! You will be missing out if you do not read this one!!!
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text:
by Zoe
I sit for a moment, trying to feel what used to be our life. There was a rhythm, a pulse, an energy that moved around us. You had an energy about you that made me safe and insane and love you more than my own life. Even watching a movie, I could feel you next to me, there was comfort in that.
In our life we moved together, even when you were on the road I knew where you were, what you were doing. You always knew where I was, we shared that way, not because we had to, but because we wanted to. We took the vows of sharing our life together very seriously. Above all, there was movement, there were the sounds I would hear and know what you were doing, and there was life, our life.
Now there is the wind in the attic, a dog barking in the distance, and the most horrible silence. I do not hear you, I do not feel you, and there is no energy, just a cold stillness that reminds me that you are gone. Above all else, there is no life here anymore, there is just me. I am nothing without you.
I had someone say to me that I needed to be strong and that if I had not been so dependent then I would be over your loss. I was not really sure if I should laugh at this person or scream.
I am strong, and professional and all of those things. What people on the outside do not understand is that the place I was happy was in your arms, you inspired me, you made me better than I was and I always strove to be the person you saw. I loved being the woman you loved. I loved being the place you were safe. I loved trusting you and knowing that you trusted me, completely and without question. Your voice could make me soar, or rock me to sleep with a tenderness I cannot put into words.
Do you hear it? It is the silence of a life lost, of a love gone, of my heart ripped in two and the screaming of my soul for my loss of you.
I cannot do this without you, I do not want to.
One breathe, one-step, one day at a time.
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IRVING, Texas - LSU football coach Les Miles is playing the latest Michigan opening differently than he did three seasons ago.
"I have received no contact from Michigan. I'm really here to speak about no other school," Miles said at a scheduled Cotton Bowl news conference Wednesday morning. "I'm here to speak about LSU. Michigan will be fine. There will always be Michigan. Speculation is not factual."
Miles' Tigers (10-2) play Texas A&M (9-3) in the Cotton Bowl at 7:30 p.m. ET Friday in Cowboys Stadium in Arlington, Texas.
"The only thing I can say to you is my focus is complete," Miles said. "We're preparing to play a great A&M team. That's my want and desire."
A former Michigan player and two-time assistant coach for the Wolverines, Miles was considered for the Michigan job after the 2007 season when Lloyd Carr stepped down. When the subject came up at various news conferences throughout that season, Miles spoke at length about his love for Michigan and the "Maize and Blue," even coming to tears at one point.
Then a day before LSU played Tennessee for the Southeastern Conference championship, Miles went as far as to say that he would talk to Michigan about its opening in the days following the game. Michigan had asked and received permission to talk to Miles at that point as long as it was after the SEC title game. Later that night, Miles agreed to a contract extension with LSU officials, who had been working on a new contract for the previous week in light of the Michigan speculation.
Miles has apparently adopted a new strategy for the latest Michigan opening, created Wednesday morning when Rich Rodriguez was officially fired.
"I have no real view of anything else but what I'm getting done right here, preparing your team, taking practice today, working in that event," Miles said. "I very much enjoy where I'm at. I don't think anybody has any reason to be concerned in any way. Let's just go practice and enjoy this week and go on."
LSU players from the 2007 team still with the Tigers said Miles was furious at a report on the morning of the SEC title game Dec. 1, 2007, by ESPN's Kirk Herbstreit that Miles would in fact be Michigan's next coach.
"If you look back at things, speculation was terrible," Miles said Wednesday. "Things were said without fact. In my opinion, it does not benefit us to go back and talk about speculation, which again is not based in any fact. Let's put that behind us and focus on the Cotton Bowl, please."
-- Glenn Guilbeau, Gannett
First-place votes in parentheses.
Football coaches' poll
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It is a human drama quite as engrossing as the story of the grand strategic deception upon which it hangs.
She pictured chatty, engrossing interviews with like-minded creative types.
The show provides an engrossing portrait of those designers and visionaries that made the high heel a symbol of status and sex.
The Bell Ringers "is a sophisticated, engrossing and important political thriller," the Post says.
The high heel is revolutionary, and evolutionary, as an engrossing Brooklyn Museum show reveals.
Fully as engrossing as anything from the pen of Hesba Stretton.
The voice opposite droned on, engrossing, dominating, hypnotic.
These have all at last given way to the newspapers—a miscellaneous study very attractive and engrossing to country gentlemen.
The greater part of the afternoon was passed in this engrossing work.
We led lives of considerable intellectual activity, constant occupation, and engrossing interest.
c.1400, "to buy up the whole stock of" (in Anglo-French from c.1300), from Old French en gros "in bulk, in a large quantity, at wholesale," as opposed to en detail. See gross.
Figurative sense of "absorb the whole attention" is first attested 1709. A parallel engross, meaning "to write (something) in large letters," is from Anglo-French engrosser, from Old French en gros "in large (letters)." Related: Engrossed; engrossing.