text:
Risk Management for Human Resources
Product ID: 701711
- Duration: 60 Min
Customer Care
Fax: +1-650-565-8542
Email: email@example.com
This HR Risk Management training will cover compliance "Hot Spots" where HR professionals need to be especially vigilant in times of complex labor laws, changing environments and workforce reorganization.
Why Should You Attend:
Human Resources should be especially vigilant in times of complex labor laws, changing environments and reorganization of the workforce. Responsibility lies heavily on Human Resources professionals to anticipate any areas which might present problems or liability for an organization. They must also take proactive measures to assure their organization has equitable and effective management and the correct talent necessary to advance the organization and execute its business plan.
This webinar will cover auditing human resources practices for compliance and liability to help identify and correct any areas that may not comply with applicable laws and/or do not comply with company policy. This action not only is a means to perform "due diligence" for your company, but is a measuring tool to determine what needs to be improved to achieve a higher standard of excellence.
Areas Covered in the Seminar:
- Determining Responsibilities for Areas in Human Resources.
- Selection and Hiring; Preventing Adverse Impact.
- The Business Case for Diversity.
- Legal Pitfalls of Labor Law
- Avoiding Discrimination Cases.
- Managing FMLA, ADA, Workers Compensation, HIPAA and GINA.
- Linking Performance with Compensation.
- Management Succession Planning.
- Training and Development.
- Promotions, Transfers, Layoffs and Terminations.
- Unemployment Compensation.
- Employee Relations and Transparency.
- Communicating Change.
Who Will Benefit:
- Vice Presidents, Directors, & Managers of Human Resources
- Employment Managers
- Employee Relations Professionals
- Chief Talent Officers
- HR Coordinators/Supervisors
- Recruiters
- HR Administrators
- HR Analysts
- Auditors
Marna Hayden, is founder and president of Hayden Resources Inc. She has 30+ years in the field of human resource management and is certified as a senior professional in human resources (SPHR). Hayden Resources Inc. provides management and human resources consulting and outsourcing services to small businesses and nonprofits, and specialized services and training to larger organizations. Hayden has held senior offices in the banking, retail, and service industries and is an adjunct faculty member for DeSales University.
Refund Policy
Registrants may cancel up to two working days prior to the course start date and will receive a letter of credit to be used towards a future course up to one year from date of issuance. ComplianceOnline would process/provide refund if the Live Webinar has been cancelled. The attendee could choose between the recorded version of the webinar or refund for any cancelled webinar. Refunds will not be given to participants who do not show up for the webinar. On-Demand Recordings can be requested in exchange.
Webinar may be cancelled due to lack of enrolment or unavoidable factors. Registrants will be notified 24hours in advance if a cancellation occurs. Substitutions can happen any time.
If you have any concern about the content of the webinar and not satisfied please contact us at below email or by call mentioning your feedback for resolution of the matter.
We respect feedback/opinions of our customers which enables us to improve our products and services. To contact us please email firstname.lastname@example.com call +1-888-717-2436 (Toll Free).
Product Reviews
This product hasn't received any reviews yet. Be the first to review this product! Write review
Pharmaceutical Compressed Air - Quality GMP Standards and RequirementsBy: Roger Cowan
Price: $249
How to Conduct a HIPAA Risk AssessmentBy: Brian Tuttle
Price: $249
Building a Vendor Qualification Program for FDA Regulated IndustriesBy: Jonathan M Lewis
Price: $249
FDA Regulations for Marketing OTC Drugs in the U.S.By: Norma Skolnik
Price: $249
Effective Annual U.S. FDA CGMP TrainingBy: John E Lincoln
Price: $249
CDISC Mapping 1: Specifications and FDA RequirementsBy: Sunil Gupta
Price: $249
Extractables and Leachables in Early Phase DevelopmentBy: Wayland Rushing
Price: $279
Veterinary Medicine and the DEA Due Diligence Requirement for Dispensing and Prescribing...By: Carlos Aquinos
Price: $229
1099 & W-9 Update - Complying with IRS Information Reporting GuidelinesBy: Miles Hutchinson
Price: $149
OSHA Recordkeeping for 2015: Beyond the OSHA 300 SummaryBy: David A. Casavant
Price: $149
Form I-9 and E-Verify, getting and staying compliantBy: Cathleen Hampton
Price: $149
Affordable Care Act Updates: What Employers need to do to PrepareBy: Vanessa G Nelson
Price: $149
Child Support: What Payroll Doesn't Know Can Hurt YouBy: Vicki M. Lambert
Price: $229
Detecting and Preventing Embezzlement in Your OrganizationBy: Peter Goldmann
Price: $249
What Employers Need to Know About Severance AgreementsBy: Janette Levey Frisch
Price: $229
FDA's Regulation of Regenerative Medicine including Stem Cell Treatments, Tissue...
Newark, NJ | Oct 19-20, 2017
FDA's New Import Program for 2017 - Strict Precision: 2-Day In-Person Seminar by Ex-FDA Official
Philadelphia, PA | Aug 24-25, 2017
Navigating the Maze for Post-Market Compliance -- Complaint Handling, MDRs, Recalls...
Minneapolis, MN | Oct 19-20, 2017
21 CFR Part 11 Compliance for SaaS/Cloud Applications: 2-day In-person Seminar
Philadelphia, PA | Sep 14-15, 2017
Quality Control Laboratory Compliance - cGMPs and GLPs: One and a Half-day In-person Seminar
San Francisco, CA | Nov 9-10, 2017
Effective Quality Oversight of Pharmaceutical Contract Manufacturing Organizati...
San Francisco, CA | Jul 27-28, 2017
Latin America: Regulatory Compliance Requirements for Life Science Products...
Philadelphia, PA | Aug 24-25, 2017
Computer System Validation - Reduce Costs and Avoid 483s: 2-Day In-Person Seminar
Philadelphia, PA | Sep 14-15, 2017
Complete 1099, TIN Matching, B-Notice, FATCA and Nonresident Alien 1042-S Compl...
San Francisco, CA | Jul 27-28, 2017
Ensuring Compliance with Advertising and Promotional Requirements for Drugs and...
Boston, MA | Nov 9-10, 2017
Managing Your FDA Inspection: Before, During and After: 2-Day In-Person Seminar by Ex-FDA Official
Tampa, FL | Aug 17-18, 2017
ACH Risk Management: 2-day Workshop
Boston, MA | Jul 20-21, 2017
Metrics & Predictive Analytics in Human Resources-Reducing Risk and Improving...
Washington, DC | Sep 14-15, 2017
Designing and Sustaining New and Existing Product Stability Testing Program
San Diego, CA | Sep 4-5, 2017
Managing an Effective AML Compliance Program: 2-day In-Person Seminar
Chicago, IL | July 20-21, 2017
General requirements for the competence of testing and calibration laboratoriesProvider: ANSI
Price: $142
IEC 62304:2015 ''Medical Device Software - Software Life Cycle Processes''Provider: SEPT
Price: $299
IEC 62304:2015 ''Medical Device Software - Software Life Cycle Processes''Provider: SEPT
Price: $149
ISO 13485 Procedure 754-Customer PropertyProvider: 13485 Store
Price: $12
Measurement management systems - Requirements for measurement processes and measuring equipmentProvider: ANSI
Price: $120
Geometrical Product Specifications (GPS) - Geometrical tolerancing - Tolerances of form, orientation...Provider: ANSI
Price: $250
Templates and Plans for Software Configuration Management Documents-Version 6.0Provider: SEPT
Price: $299
Computer System Validation Master PlanProvider: LabCompliance
Price: $90
Zero Acceptance Number Sampling Plan for Receiving, In-Process and Final InspectionProvider: Quality-Control-Plan
Price: $37
Standard Operating Procedure: FDA InspectionsProvider: LabCompliance
Price: $49
AS9003 Comprehensive Quality System Kit for Inspection and Test Quality Control SystemProvider: At-PQC
Price: $397
ISO 13485 and FDA Compliant Internal Audit Tools: Checklist, Procedure and FormsProvider: 13485 Store
Price: $95
Template for a Software Maintenance Plan - Fourth EditionProvider: SEPT
Price: $99
Sarbanes Oxley Treasury Risks and ControlsProvider: Audit Net
Price: $50
ISO 13485 Gap ChecklistProvider: 13485 Store
Price: $59


text:
Moroccan-Spiced Lamb Appetizer
Ground lamb and Moroccan-inspired herbs and spices combine to make the filling for these tasty pastry-wrapped appetizers. They're a great choice for entertaining and can easily be made ahead and baked just before serving. A dipping sauce of Greek yogurt and mango chutney complements the seasonings in the lamb perfectly.
Moroccan-Spiced Lamb Appetizer
Prep Time: 15 minutes Cook Time: 20 minutes Yield: 24 pieces
Prep Time: 15 minutes
Cook Time: 20 minutes
Yield: 24 pieces
- Ingredients:
- 3/4 lb ground lamb
- 2 large shallots, finely chopped
- 2 cloves garlic, finely chopped
- 1/3 cup fresh mint leaves, chopped
- 1/4 cup fresh parsley, chopped
- 1/2 teaspoon salt
- 1/8 teaspoon freshly ground black pepper
- 1/2 teaspoon ground cumin
- 1/2 teaspoon ground coriander
- 1 sheet frozen puff pastry dough, thawed
- All purpose flour
- 1 large egg, lightly beaten
- 1/3 cup plain Greek yogurt
- 1/4 cup mango chutney
- Pinch of cayenne
Place the lamb, shallots, garlic, mint, parsley, salt, pepper, cumin and coriander in a bowl. Combine thoroughly - using your hands works the best.
Unfold the pastry sheet onto a lightly floured flat surface and roll out gently to smooth the creases and stretch the sheet to a 10 x 12-inch rectangle. Slice the pastry into 3 strips (10 x 4-inch) and brush with beaten egg.
Place 1/3 of the lamb mixture lengthwise down the middle of each strip of pastry. Fold the long side of the pastry over the filling as tightly as possible and press to seal. Place each roll, seam side down on a piece of plastic wrap. Wrap tightly and refrigerate for at least 1 hour.
Preheat the oven to 425°F and line a baking sheet with parchment. Unwrap the pastry rolls and, using a sharp knife, slice them into 8 pieces each. Arrange in a single layer on the prepared baking sheet and brush each piece with beaten egg. Bake for 20 minutes, or until golden brown.
Combine the Greek yogurt, chutney and cayenne in a small bowl and serve as a dipping sauce.
Recipe adapted from PuffPastry.com (Pepperidge Farm)
Filed under: Appetizers, ground lamb, mango chutney, mint, puff pastry
SOURCE: MyGourmetConnection.com
comments & replies
Yum, these look fabulous! I love that you can make them ahead of time!
Made this recipes last night with sauteed vegetables for dinner--SO GOOD! Can't beat a delicious AND easy recipe. Thanks!
A friend brought these to a party at our house. Everyone loved them and I can't wait to make them for myself. So tasty. Can they be prepared, frozen then baked when ready to serve?
« Scalloped Potatoes with Fontina, Onions and Sage Sun-Dried Tomato and Spinach Wheels »

subset: commoncrawl


text:
The role of nicotine replacement therapy for temporary abstinence in the home to protect children from environmental tobacco smoke exposure: a qualitative study with disadvantaged smokers
Health behavior, health promotion and society
Nicotine replacement therapy (NRT) has recently been licensed to help smokers to abstain from smoking for short time periods and recent studies have shown that 8-14% of smokers are regularly using NRT to cope when they cannot or are not allowed to smoke. These data suggest that, potentially, NRT for temporary abstinence might be an acceptable method to help smoking caregivers, who are not able to stop smoking completely, to avoid smoking whilst inside their home in order to protect their children from the harms of environmental tobacco smoke (ETS). The aim of this study was therefore to explore the concept of using NRT for temporary abstinence in the home, to protect children from exposure to ETS.
Qualitative in-depth interviews were conducted with thirty six disadvantaged smoking parents who were currently, or had recently stopped smoking in the home with at least one child under the age of five. Parents were recruited from Children's Centres and Health Visitor Clinics in Nottingham, UK. Interviews were audio recorded and transcribed verbatim. Data were coded and analysed thematically to identify emergent main and subthemes.
Overall, participants responded negatively to the concept of attempting temporary abstinence in the home in general and more specifically to the use of NRT whilst at home to reduce children's exposure to ETS. Many parents would prefer to either attempt cutting down or quitting completely to make a substantial effort to change their smoking behaviour. There was limited interest in the use of NRT for temporary abstinence in the home as a first step to quitting, although some parents did express a willingness to use NRT to cut down as a first step to quitting.
Disadvantaged smoking parents were reluctant to initiate and maintain temporary abstinence with or without NRT as a way of making their homes smoke free to protect their children's health. More education about the specific risks of ETS to their children and the utility of NRT for use in the home might be needed to have a public health impact on children's health.
Exposure to environmental tobacco smoke (ETS) in children is a major public health problem, causing serious health consequences
Nicotine replacement therapy (NRT) is an effective and widely used treatment for smoking cessation
Two sets of qualitative in-depth interview data (n=36) were combined in the current study to explore the views of smokers with young children on using NRT to abstain from smoking in the home. One-to-one interviews were chosen in both studies to enable open discussion of anticipated sensitive social and psychological issues
These two interview studies form part of a larger body of research which aims to develop an effective intervention to reduce children's exposure to domestic ETS. The aim of the first study was to explore home smoking behaviours, the motivators and barriers to smoke-free homes, and to identify the positive levers that health care professionals can utilise when supporting smoking caregivers to change their behaviours. The aim of the second study was to further investigate the specific details of the intervention, in particular, to explore in more detail the use of NRT for temporary abstinence in the home to protect children from ETS. The interview guides were developed from the literature and through discussions with the Children's Centre and health visitor staff that provided the authors with useful insights into the social challenges facing their clients. The guides were modified further throughout the data collection to incorporate any new themes. Guide modification was facilitated by immediate post-interview de-briefing between the interviewers. The first set of interviews was carried out by both LLJ and OA and the second set of interviews carried out by LLJ and another interviewer. The discussion guide included exploration of topics around previous quit attempts, previous and future use of NRT, the concept of temporary abstinence and the use of NRT for optional temporary abstinence in the home. We anticipated that the concept of temporary abstinence might be challenging for interviewees to understand and therefore invested time and effort during interviews to help the participants comprehend this. Once we were satisfied that participants adequately understood the concept of temporary abstinence, we explored their views and attitudes towards initiating and maintaining optional temporary abstinence in their homes in general, and also to using NRT for optional temporary abstinence in their homes. The participants were also provided with a NRT summary sheet prior to the interview which included a brief description of some NRT products. For those participants who had no previous experience of NRT, we showed them gum and lozenge samples as visual aids. We have previously analysed the first interview study
Data analysis was ongoing throughout the period of data collection and regular discussions were held between the interviewers and within the rest of the research team. Each interview was digitally audio-recorded and transcribed verbatim by an external specialist transcription company. Each transcript was carefully checked for transcription errors to ensure data quality. Analysis of the transcripts was facilitated by the use of NVivo software version 8 (QSR International Pty Ltd, Australia). The interviewers independently generated an open coding framework, utilising the six phase process of Braun and Clarke
In total 36 semi-structured interviews were conducted with self-reported smokers. Although all interviewees were current smokers, they reported a variety of smoking behaviours within the home. Of the 36 interviews, 27 were with mothers, one with a grandmother, a resident carer, and eight with fathers. Eighty one per cent were unemployed or considered themselves to be a house-wife. On average, there were two children living in each household (range, one to six), and in 48% of the households there were two or more adult smokers living in the home.
In this manuscript data relating to the following themes are reported:
1. Participants' attitudes to the concept of optional temporary abstinence from smoking in the home
2. Participants' past experiences and perceptions of NRT use
3. Participants' views about using NRT to help them make their homes smoke-free
Participants' attitude to the concept of optional temporary abstinence
Overall, most participants were generally negative about the idea of temporary abstinence in the home. Many did not believe that they could successfully avoid smoking inside their homes (Table
Experience with NRT
Most participants reported previous use of NRT and understood that NRT provides nicotine in a medicinal form rather than from cigarettes which helps to overcome the cravings arising from nicotine withdrawal. However, some were still sceptical about the health advantages of using NRT instead of cigarettes (Table
Use of NRT for optional temporary abstinence in the homes
Exploration of interviewees' previous experiences of NRT often facilitated lengthy discussions about the potential use of NRT to help the participants make their homes smoke-free. An overwhelming majority of interviewees expressed generally negative attitudes about using NRT to help them to avoid smoking in their homes. One of the participants, a father of one, voluntarily described how he had already managed to initiate and maintain temporary abstinence to make his home completely smoke free by using nicotine gum to control his cravings inside the house, even though he was not familiar with the terminology of temporary abstinence. His reason for stopping smoking inside the house was his son's health. However, when asked about the potential use of NRT by other smokers to help them stop smoking in the home, he promptly talked about his desire to use NRT to help him stop smoking altogether (Table
Others were sceptical that using NRT for optional temporary abstinence alone would not address the more important need to change their smoking routine (Table
To our knowledge, this is the first study reporting smokers' views on the value of trying to achieve temporary abstinence from smoking when in the home and the potential role of NRT in this context. We found a generally negative attitude both to the concept of optional temporary abstinence and the use of NRT to achieve it, for a number of reasons. First, many smokers felt that the strength of their addiction and their deeply ingrained smoking routines would be too difficult to overcome for them to stop smoking temporarily whilst inside their home. A number of caregivers also stated a preference for trying to stop smoking altogether, rather than "just" stopping in the house. Despite the fact that most of our participants had previously made failed quit attempts, many would still consider using NRT to help them to quit, either abruptly or after cutting down.
In our previous analysis, we showed that interviewees had an incomplete knowledge and confusion about, and a lack of engagement with the effects of ETS on children's health
It is also possible that the failure to engage with the concept of temporary abstinence in our study group could be partly explained by the relative lack of exposure to situations where the smokers have to abstain from smoking. Many of our participants were unemployed or homemakers, and it is likely that they spend less time in situations of enforced temporary abstinence from smoking than more advantaged households with higher employment rates where smokers are potentially more used to the concept of enforced temporary abstinence and could then transfer this approach to their homes. A major strength of our study is that we explored the views of socio-economically disadvantaged smokers whose children would, potentially, have the most to gain from reduced exposure to ETS. However, it is not clear how closely the findings from this sample would relate to more affluent households where children have less exposure to ETS in the home
Most of our participants had previously tried unsuccessfully to stop smoking, and therefore may have had more negatively biased views about the use of NRT, which were described in other studies
Despite the negative views, there was still some support for using NRT to achieve optional temporary abstinence, as demonstrated by a father who used NRT successfully to stop smoking in the home and another participant who could see a role for NRT and optional temporary abstinence as a first step towards quitting. Of note, most of our failed quitters could still see themselves using NRT in more traditional ways, in particular, for smoking reduction – either through cutting down, or cutting down to quit. With appropriate support to ensure smokers cut out the cigarettes smoked in the home, such smoking reduction could lead to benefits to children, as well as the smokers' personal health. A possible implication for healthcare professionals who are involved with smoking families is that it is important to take a person-centred approach, exploring smoker's previous experiences and knowledge about temporary abstinence and NRT and use them as positive levers to make a permanent change in their household smoking habits.
The findings of our study provide insight into the relatively unexplored ways of protecting children from ETS, which could inform any future interventions around smoke-free homes and ETS exposure. Future research around clinical interventions could explore the possible effectiveness of education on the risks of ETS and lack of effect of partial restrictions of smoking in the homes.
Caregivers in our study did not engage with the concept of temporary abstinence as a means of protecting children from ETS at home. This could be partly explained by the complex social and psychological aspects of smoking in the lives of these disadvantaged families but also by a lack of knowledge about the specific health risks to children of ETS exposure. We also identified a lack of support for using NRT to achieve temporary abstinence in the home, which may be attributed to people's incorrect beliefs about the efficacy of NRT. Nevertheless, our study suggests that there is still a role for NRT as some families may be receptive to the idea of using NRT for optional temporary abstinence, and others might be open to using NRT to help them cut down, or cut down to quit and could be encouraged to do so in a way to protect their children's health. These conclusions, however, may only be valid for disadvantaged families.
ETS: Environmental tobacco smoke; NRT: Nicotine replacement therapy
Competing interest
The authors declare that they have no competing interests.
Authors' contributions
OA drafted the manuscript, contributed to the development of the interview guide, carried out interviews and lead the analysis and interpretation of results. TC, AM and SL were involved in the design of the study and the interview guide, participated in discussions around interpretation of the results, commented on drafts of the manuscript and critically reviewed the final version. LLJ contributed to the study design and interview guide development, carried out interviews, was involved in analysis and interpretation of results, commented on drafts of the manuscript and critically reviewed the final version. All authors read and approved the final manuscript.
The authors would like to thank Dr Jo Longman, University of Sydney for her contribution to the discussions of the project; Miss Sarah Field-Richards for helping to conduct interviews in the second study; the Children's Centre and health visiting staff for their help and support and the families who gave up their time to participate.
This article presents independent research commissioned by the National Institute for Health Research (NIHR) under its Program Grants for Applied Research funding scheme (RP-PG-0608-10020). The views expressed in this article are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. In addition, this study was supported by core funding to the UK Centre for Tobacco Control Studies (
Health effects of passive smoking-10: Summary of effects of parental smoking on the respiratory health of children and implications for research
Smoke-free homes in England: prevalence, trends and validation by cotinine in children
Effect of strategies to reduce exposure of infants to environmental tobacco smoke in the home: cross sectional survey
Nicotine replacement therapy for smoking cessation
Use of nicotine replacement therapy for smoking reduction and during enforced temporary abstinence: a national survey of English smokers
Trends in and predictors of second-hand smoke exposure indexed by cotinine in children in England from 1996 to 2006
'I've never ever let anyone hold the kids while they've got ciggies': moral tales of maternal smoking practices
'You think that I'm smoking and they're not': why mothers still smoke in the home
Disadvantaged mothers, young children and smoking in the home: mothers' use of space within their homes
The motivators and barriers to a smoke-free home among disadvantaged caregivers: identifying the positive levers for change
Imagine all that smoke in their lungs': parents' perceptions of young children's tolerance of tobacco smoke
Using thematic analysis in psychology
Environmental tobacco smoke exposure of young children–attitudes and health-risk awareness in the Nordic countries
Reasons for not using smoking cessation aids
Barriers and motivators to gaining access to smoking cessation services amongst deprived smokers–a qualitative study
Understanding why smokers do not want to use nicotine dependence medications to stop smoking: qualitative and quantitative studies
'I came back here and started smoking again': perceptions and experiences of quitting among disadvantaged smokers
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
Roll out the red carpet–it's awards season! The teams at Daily's Cocktails and Wholly Guacamole have paired up to bring you a great review opportunity. There's something about a tasty cocktail and a dish of guacamole that goes together like a wonderful film and an Oscar, or like your best friend and a movie night. So why not put it all together?
I love the Oscar's and it was so much fun to get this kit from Wholly Guacamole and Daily's Cocktails! It took me a while to select a movie to watch for my little Oscar viewing party with my husband. I eventually chose one of my all-time favorites which is 1997 Best Picture Winner- Titanic! We settled down during a cold spell in Florida this weekend with blankets and drinks from Daily's and nibbles from Wholly Guacamole!
Check out that pink lemonade light from Daily's! It was so yummy and couldn't be easier. Just buy it (I bought mine at Walmart), put it in the freezer and when you're ready to drink it pull it out and serve! The alcohol is already in it and you have yourself a restaurant quality frozen drink in minutes!
I loved the products Wholly Guacamole sent as well. The mango pepper salsa was so delicious, sweet and spicy at the same time! We are both guacamole lovers so we couldn't wait to try the Wholly Stuffed Jalapenos pictured above! Here is the recipe courtesy of Wholly Guacamole:
- 12 jalapeño peppers
- 1 (8 ounce) package cream cheese
- 1 7oz package of Wholly Guacamole® dip
- 24 slices of bacon
- Preheat oven to 425 degrees F
- Slice jalapeños in half lengthwise. Using a spoon, scoop out the seeds.
- Mix cream cheese and Wholly Guacamole dip together.
- Stuff each jalapeño half with cream cheese mixture. Then, wrap a slice of bacon fully around each stuffed jalapeño half.
- Place stuffed jalapeños on a medium baking sheet. Bake in oven for 20 minutes. Using tongs, turn over and cook for an additional 20 minutes or until bacon is fully cooked, browned and crispy.
- Grill over indirect heat for 8-10 minutes or until bacon is fully cooked, browned and crispy.
This was the perfect Oscar's movie night at home courtesy of Wholly Guacamole and Daily's Cocktails – a wonderful partnership!
Enter the Giveaway!
You can win a fabulous prize package including: Four Wholly Guacamole and three Wholly Salsa products in a variety of yummy flavors, a $20 Walmart gift card to pick up an assortment of Daily's Cocktails Pouches, promotional items from both Daily's and Wholly Guacamole, and your very own red carpet! Please enter the giveaway on the widget below. Email and feed subscribers will need to click over to my actual site to enter.
I received the same prize as the winner. All opinions remain my own.
Check out HOT Amazon deals on your favorite items!


text:
10W Super Bright LED - Warm White
Deliveryfrom just £2.50
No Quibblereturns policy
Securepayment system
Next Day DeliveryOrder by 2PM*
Share this Product
This 10W super bright LED can be used as a flash searchlight for your robot projects. It consists of 9 separate LEDs and has a luminance of 500LM. Comes in various colors.
- Rated Power: 10W
- Luminance: 500LM
- Working Voltage : 9V-11V(With Heat Sink); 7.5V-8.5V(Without Heat Sink)
- Rated Current: 1000mA
- Color Temperature: 3000K-4000K
- Angle: 120°
- Working Temperature: -20°C ~ 60°C
- Reserving Temperature: -20°C ~ 60°C
- Size: 38mm*23mm (1.50"*0.91")
- Weight: 10g


text:
Water Dept revises river peak timing
The Water Department now says that River Murray water levels are set to peak today at Blanchetown.
The peak had been expected to reach the town by last Wednesday but the department's Andrew Beal says the forecast has since changed.
He says predicting the peak is not an "absolute science".
"There are various backwater effects, you know the drag of the riverbank and flood plains, and those wind effects and the various factors come into play around pumping, so it's our best estimate based on the historic record and generally it has proven to be pretty accurate," he said.
Topics: rivers, murray-darling-basin, water, blanchetown-5357, renmark-5341


text:
Perl offers the benefit of being able to read the large majority of information that travels across the Web...
Code Line...
When you're clipping along and writing code, it's nice to be able to have a program like this one c...
When you are working on getting the proper looking circuit board and know it is going to work properly you ...
What's Hot
- Nhibernate Query Analyzer 0.7Nhibernate Query Analyzer is a free Windows program that will allow programmers and developers to understan...6545
- DJ Java Decompiler 184.108.40.206The DJ Java Decompiler system is a Windows program that is intended to decode Java programs into readable s...543
- Immunity Debugger 1.83Immunity Debugger is a free program that allows skilled professional developers to look through exploits, m...533
- Entomologist 1.1Developed by Matt Barringer, Entomologist is a GPL-licensed client for bug tracking that is compatible with...5644
- Lightning PL/pgSQL Debugger Client 22.214.171.124Developed by AM Software Design, Lightning PL/pgSQL Debugger Client is a freeware application that does not...7655
- OCI Debugger 184.108.40.206Developed by Dzmitry Piatrushenia, OCI Debugger is a freeware application whose core design is to trace OCI...7656
- MIPS Interactive Learning Environment PreAlphaMIPS Interactive Learning Environment is a program to help students and developers learn how to program in ...6545
- Google Refine 2.5 r2407Developed by the Google Refine Team, Google Refine is a freeware application that facilitates working with ...654
- Rec Studio 4.0 BetaRec Studio is a freeware program that offers users the ability to open a raw executable or Windows executab...436
- Bug Finder 1.1.1Developed by Antonio Petricca, Bug Finder is a GPL-licensed application whose goal is to be a passive debug...654
- <<1...2930313233...57>>
- Ableton Live 8Ableton Live offers a music lover the chance to produce their vision of music excellence. Turn any song int...624
- FreeBASIC 0.24FreeBASIC was originally designed to be a code compatible yet entirely free alternative to Microsofte Quick...143
- BloodshedSoftware Dev-C++ 5.0When you are trying to get your own video or programming done it can be hard because of all the software th...1219
- HTML Snapshot 2.1.2011.1111HTML Snapshot is an easy way to grab a screen shot of a web page, and it allows you many different options....19677
- Code Line Counter Pro Java Version 4.1 Build 184.108.40.206When you're clipping along and writing code, it's nice to be able to have a program like this one c...1798
- PostgresDAC 2.7.0Try the new C++ Builder from PostgreSQL, PostgresDAC. With this free utility, you can create Delphi/C++Buil...5461
- Graphical Grammar Studio Beta Originally developed as an Open Source Java designed tool, Graphical Grammar Studio is commonl...6222
- EiffelStudio 184.108.40.20681EiffelStudio, programmer's language tool, needs an IDE to function properly. This particular download, ...5775
- VisioForge Video Capture SDK .Net Edition 188.8.131.52VisioForge Video Capture SDK .Net Edition is professional grade development software designed for video cap...23006
- Universal SQL Editor 220.127.116.11 Ming software has developed a new Universal SQL Editor. This application allows users to easil...3251
- Devpad 4.7Available as freeware from develop Semagsoft, Devpad is a simple code editor, similar to Windows Notepad or...8924
- Zend Studio 9.0.0For just a product trial, Zend Studio is out of sight! I hate writing code; it's the most boring and of...39622
- Class Editor 2.23Class editor allows consumers to edit their Java class file types by using a simple and elegant tool. Class...6479
[ up one ]
[ up one ]
- Coding languages / Compilers
- Components & Libraries
- Debuggers / Decompilers / Dissasemblers
- File Editors
- Other Programming Files
- Packers / Crypters / Protectors
- Patchers
CaptureEditRecorderRestoreConvertVideo playerVideo converterRecoveryViewerPlayerEditorConverterBackupOrganizerRecoverAudio playerText editorCreateCreatorManager
Software developers
Like softango on
Top Software
Latest videos
FX ChemStructwww.softango.com
Software answers


text:
Helmut Haller, who scored for West Germany in the 1966 World Cup final against England and took the match ball home before returning it to the Football Association 30 years later, has died at the age of 73, his home club Augsburg said yesterday.
Haller, a blond, stocky striker who gave the Germans an early 1-0 lead at Wembley with a turn and shot after a rare Ray Wilson error, won 33 caps and scored 13 goals for his country. He also featured in the 1962 and 1970 World Cups and played for 11 years in Italy, winning three league titles with Bologna and Juventus.Reuse content


text:
Internal Security in India
Crime and Criminal Tracking Network System (CCTNS)
October 5, 2015
The UPA Government had initiated the Crime and Criminal Tracking Network System (CCTNS) project in 2009 as part of its police modernisation programme under the national e-governance project. It was conceived to bring all 16,000 police stations in India under a single network to counter terror challenges. Objectives...
Federal Structure, Diversity and Insurgency in India
June 23, 2015
Our country has been hailed as a triumph of democracy. India is known as largest functioning democracy in the world and also a beacon of democracy to the world. The cornerstone of success of democracy is the way the power has been distributed by the constitution. Further,...
Essay: Radicalization – The role of the Internet & India's reponse
June 10, 2015
Internet has revolutionised our lives and has changed many aspects of how we work, live, shop, conduct our hobbies and the ways we form and maintain our relationships. Due to its global reach and unbounded fetter, Internet has become the integral part of business, recreation, education, personal...
Illicit drug trade along Golden Triangle & India's North East
August 21, 2014
"There are serious implications for North East India due to illicit drug trade along the Golden Triangle." Elaborate various dimensions of the issues and stakeholders involved.
National Cyber Security Policy
August 13, 2014
In 2013, Ministry of Communication and Information Technology of the Government of India had released the National Cyber Security Policy to protect information, such as personal information, financial/banking information, sovereign data etc. The policy has proposed to set up different bodies to deal with various levels of...


text:
Florida RB running mouth on Twitter about Michigan
The disrespect is crazy... I can't wait till we beat the brakes off Michigan— Mark Thompson (@InMarkWeTrust) July 17, 2017
Twitter fingers a big thing these days I guess.....— Khalid Hill (@Thatboylid80) July 18, 2017
We don't use brakes anyways, foot always on the— Chase Winovich (@Chase_Winovich) July 18, 2017
Hurst also retweeted the no-name RB's tweet.
I remember the last time one of them ran their shark-licker about our team-
#Gators CB Jalen Tabor on Jabrill Peppers playing offense: "We have 11 Jabrill Peppers on our defense."— Nick de la Torre (@NickdelaTorreGC) December 28, 2015
Good times.
Drake Johnson Running Track, Not Playing Football
"Drake Johnson is going to continue at Michigan, take classes this fall, the latest is that he's not going to participate in football and concentrate on track," Harbaugh told reporters Monday in Ann Arbor.
Michigan @ Wisconsin Football Tickets On Sale Now
Single game tickets for Wisconsin went out sale today at 830. There are still tickets available. For some reason if you do purchase by seat it looks sold out, but if you purchase by price, tickets come up.
OT: Larry Fedora reacts to new (and proposed) rule changes...
He doesn't like most of the new rule changes in college football which many feel level the recruiting playing field for northern schools. He doesn't like the rule changes which were put in place to allow for more fall camp since 2-a-days are now prohibited.
"There's quite a few that I don't like," Fedora said from the Westin in Charlotte, N.C., according to Scout. "I don't like the fact that now guys can take official visits for eight months of the year. I do not like that. I do not like guys taking official visits in April, May and June. I don't like that this [event] started this week and not a week later. That cut into another week of my vacation. What I'm getting to there is now they've backed camp up so you can go on the 27th, so now we've moved football into July. Now they're talking about going to a 14-week schedule, so who's going to say that's not going to go another week earlier so you can get your guys prepared?
Poor guy, lost out on a week of vacation because of ACC Media Day for his job that pays him multiple millions of dollars. He should've called up Hugh Freeze and they could've had a family double date vacation earlier this month. They could've sat around the bonfire and cooked up some burgers, ribs, and their next institutional scandal.
Here's another breakdown of the rule changes...
Among the college football rule changes for 2017:
- There are now two signing periods. In 2017, players will have their first opportunity to officially sign from Dec. 20-22.
- Extended recruiting season that lengthens the period for official visits to April 1 of the prospect's junior high school season.
- Teams are allowed 10 assistant coaches starting Jan. 9, 2018.
- Two-a-day practices during training camp are banned. If teams practice twice per day, the extra session must be a film study, walkthrough without pads or conditioning.
- Teams were allowed to request training camp to begin in July if the ban on two-a-day practices disrupted their schedule.
Your favorite college football gameday experience not at Michigan Stadium
WD's post of records at other B1G stadiums got me to thinking...what's the best gameday experience you've had at another B1G school? Or outside the B1G?
I haven't been to all the other B1G schools, but I'm close. Iowa and Wisconsin have to be my favorites, with Iowa a slight advantage because their fans were great. I think Iowa City is a little underappreciated, and Kinnick is an awesome venue.
Outside the B1G, Tennessee stands out - even though they're still bitter about the Heisman - among a number of SEC, ACC, ND and PAC## stops. (Is it just me, or does a BIG12 visit other than Texas seem like a waste of time?). I will add, any college football should try to see one game at ND - it is a great experience too though I know the view here is THWND.
The top of my list to still visit (outside my last couple B1Gs) are 'Bama, LSU, Texas, and Washington. I'm curious to hear of favorites from the board to add to my list.
Thanks in advance.


text:
Live on Skysports 1: Mon 19.45: In the SPL, Aberdeen are 12/5 with Sportingbet to hit two or more goals at St Johnstone on Monday.
On the back of two narrow defeats against the Old Firm, Aberdeen have a chance to get back on the winning trail at St Johnstone on Monday where they have returned unbeaten from in their last three visits. Despite such a crisp record, it's the visitors who kick off as Betdaq's 3.5 (5/2) outsiders.
Having netted an impressive nine goals in their last four outings, the Dons have clearly not had problems scoring, so when Sportingbet quote them at 12/5 to hit two goals or more, shrewd punters might be inclined to take advantage. Boylesports also post a tempting 4/1 against the away side scoring in both halves of the match, while Ladbrokes shout 9/2 in favour of them enjoying a one-goal margin of victory.
Compare all SPL odds and bet at the best price.


text:
Josh Levitt
I have a voice that can range from high pitched to extremely low and growly, and I have always been good at impressions. Prospective clients should hire me because I have experience with sound and recording(have done some voice recording for some online stuff and I am a producer/musician), have the equipment to produce high quality recordings, and am very ambitious and hard working, and have wanted to break into the sound industry for some time now.
English (North American), English, English (British), English (Irish), English (Australian)
Australian, British, Irish, North American
Child, Middle Aged, Senior, Teen, Young Adult
Special Skills
Audiobooks, Business, Cartoons, Documentaries, Educational, Internet, Jingles, Movie Trailers, Music, Podcasting, Radio, Telephone, Television, Videogames
I personally am a producer/musician/singer and record stuff of my own all the time
I have recorded music and audio for an iphone app and will be doing more projects with the company in the future
recorded and did voices for online cartoon
working on an online cartoon of my own (ask if intersted!)
Did "commercial guy" voice for a short online video
Will be attending school for audio engineering this september
good mic
Computer & Software
good computer, windows 7, reason 5, audacity, fruityloops
Special Equipment
Delivery Methods
Payment Terms
Hire Josh as a voice actor. Payment is made through Voices.com SurePay, an escrow service that guarantees your work is done to your satisfaction. Send payment securely by Visa, Mastercard or PayPal through Voices.com then download your files from the website.
Watch a video to see how to make a payment
Next Steps
To contact Josh Levitt about your project, request a quote today. We'll walk you through the process step-by-step. It's fast and easy.
This talent has not uploaded any demos yet.
Title of Your New Demo 7777 Listens
Hire Josh Levitt as a voice actor. Working with Josh Levitt is fast and easy. We'll walk you through the process step-by-step.
Request a quote for your project today.


text:
Status: Open
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Bergen Urological Associates in Hackensack, New Jersey, includes urologists Dr. Andrew Siegel, Dr. Stuart Levey, and Dr. Marin Goldstein. Specialties include pelvic relaxation, incontinence, kidney stones, and voiding dysfunction.
Stuart Levey, MD provides urology services in Hackensack, NJ. A Urologist is trained to diagnose, treat and manage diseases of the urinary tract and male reproductive system, including prostatitis, kidney stones and urinary tract infections.
Please call Bergen Urological Associates at (201) 342-6600 to schedule an appointment in Hackensack, NJ or to get more information.
Bergen Urological Associates provides oncology services in Hackensack, NJ. Oncology includes the diagnosis and treatment of breast cancer, skin cancer, prostate cancer, and many other forms of cancer.
Contact Stuart Levey, MD at (201) 342-6600 for specific information about cancer treatment in Hackensack, NJ.
Be the first NJ.com user to add photos or videos of Bergen Urological Associates Pa
Very poor customer service. Phone calls always transferred to voicemail and you don't get a call from them after leaving several voice messages. Simple prescription issue can't be handled well....
This urology office is unable to manage basic phone calls. Every time I call to get any answers, its directed to voicemail or an answering service. I will...
Bergen Urological Associates PA is located at 20 Prospect Ave Ste 607, Hackensack, NJ. This business specializes in Doctors & Clinics.
Stuart Levey, MD practices as a Urologist in Hackensack, NJ.Stuart Levey, MD graduated from Finch U Of Hs/Chicago Med Sch, North Chicago Il 60664.


text:
|Go get'em, Soleil!
|Episode 39
|Episode Information
Soreyuke, Soreiyu!
|Go get'em, Soleil!
|Air Date
|Japanese Air Date
|July 11th, 2013
|Featured Songs
|Diamond Happy
|Insert Song
|Diamond Happy
|Episode guide
|← Starberry Parfait♪
|Girl Meets Girl →
Go get'em, Soleil! (それゆけ、ソレイユ!) is the 39th episode of Aikatsu! TV anime series and the 39th episode of its "1st Season" (
Since Soleil has made its public debut, another live concert has been decided. So to test the new unit, Orihime gives them the mission of filling every seat by that evening, and if they fail they must cancel the performance.
After finishing their photo-shoot, Tristar relaxes on the tour bus. As Kaede complains over the heat, Mizuki informs them of today's plans and mentions that they will be heading back to the Academy that evening in order to discuss everyone's upcoming idoling plans.
At an interview, Soleil is giving everyone some news for an upcoming event. While this is going on, Raichi is watching from the Hoshimiya home while Ringo attends to a customer in front of the shop. The woman notices the poster of Soleil and Raichi reveals that Ichigo is his sister. The woman doesn't know who the unit is though, then informs him that she doesn't really listen to music anymore. After they watch her struggle with her items, they offer to bring them to her home later on for her.
The girls hold a handshake event afterwards, which Orihime and Johnny happened to watch from her office. While Johnny thinks it went well, Orihime seems somewhat tense and points out that they need to be a little harder on the girls now, in order to see to it that they succeed. So Johnny goes to fetch the girls and brings them to the park Ichigo used to come to, then he goes over the message Orihime sent to them. In it she informs the girls that they will have to cancel their concert they plan to hold if they are unable to fill every single seat in the stadium. She wishes them luck, then ends the message.
While Ichigo is excited, Ran isn't really surprised by the news, and Aoi is busy trying to post a message about it on Kirakiratter. Johnny stops the girls before they can go however, and mentions that they cannot use anything to send word out on the performance. They will have to do it all entirely by themselves and learn to advertise without the use of anything digital or related to the Media. With that Johnny heads back and happens to find Orihime. He worries that this task may be too hard for the new unit, but she claims that she is sure they can do it. While the girls may be able to use their popularity on TV and Internet, if they can accomplish this then it would take them to brand new heights.
The girls take the opportunity to stand on the stage at the park and they try to talk to the fans in the area. But they don't get too much of a reaction and can't figure out why that is until Ran explains that it probably has to do with the fact that only some people know who they are. After that Ichigo gets an idea and has Aoi and Ran follow her.
Elsewhere, Otome, Sakura, and Shion are going over their units charming new introduction. Sakura and Otome enjoy it, but Shion finds it too embarrassing and asks if they really have to do this. She isn't the cutesy-type, but they try to convince her by comparing it to her acting. On television she is cool and dramatic, but in this idol group she can reveal her brand new self: a cute, unseen Shion. This seems to inspire her and she mentions that there was a role coming up that she wished to try out for, but she didn't think it would fit her much. So once again they try the introduction and this time she has a lot more fun.
Ichigo's plan is soon revealed. They run all around town and call out to everyone they pass to encourage them to come to the performance that evening. Since Ran and Aoi approve o the idea they follow Ichigo and managed to gather a huge crowd in town to help them out. It turns out that only a few have not heard of them, so they are able to get a lot of people, including Raichi, who happened to spot them and brings them back home for lunch.
While there, Ringo asks the girls if they are okay with such a small lunch, but they assure that it is fine since they don't have a lot of time to spare anyway. Raichi takes a moment to ask Ran and Aoi if Ichigo is really a good leader, and they claim she is doing great - especially since she is the only one capable of leading Soleil, because of who she is. This touches Ichigo deeply and she thanks them for always being there for her. They begin to discuss the importance of the location they were at earlier on and Aoi and Ran agree that the concert will need to be held in the park.
Suddenly Ichigo spots the bag belonging to the elderly woman from earlier and brings it up. Ringo and Raichi explain what happened, along with the plans of having Raichi drop it off, but the trio decide to come with him. Upon arrival Ichigo asks the woman to come to the concert, but she isn't really sure until they can convince her to at least give it some thought. Ichigo then asks her to bring some friends, and to the girls surprise they are surrounded by a crowd of people again. A man then asks the girls to come over to his company and allows them to ride on his conveyor belt, then a man working spots Aoi and asks her to come and meet his friends a the Police Station - as they are all big fans of the Naughty Detective series.
Meanwhile, Otome, Sakura, and Shion are observing a sweet cake in the bakery when they happen to see Soleil march by with Raichi. They see a huge crowd following them as they announce their live concert for that evening. The girls are surprised to see that even animals are seen flocking to them, so Otome suggests that they go to watch the performance in order to observe Soleil closely.
Eventually concert time comes around and Johnny informs the trio that there is still one final seat that has been left open. If even one is left, the concert will be canceled, which makes the girls worry that they will have failed. But Ichigo stops for a moment to observe everyone in the audience before she asks if they can hold the concert anyway. She doesn't want to let down everyone who had showed up. So Johnny goes to let Orihime know of what is going on while the girls go out to change and perform to "Diamond Happy".
After the concert it is revealed that Orihime has showed up, much to Johnny's surprise. He hesitates while trying to explain what happened, but she cuts him off by saying that even though the girls failed her task, they did manage to attract a lot of people during the performance and they couldn't even find seats. Everyone is so happy and having fun that many were just drawn in.
Once the concert ends, Raichi and Ringo, as well as the older woman come over to congratulate the girls. She mentions an interest in hearing the girls perform again and Ringo offers to let her know regarding Soleil's future plans.
That night, Soleil comes into the office to speak to Orhime. She congratulates the girls and hands over their Summer present, as promised earlier. Tristar steps into the office and after, she informs the six girls that they will be performing together for a special Summer Tour as a six idol unit.
Character Appearances
- Ichigo Hoshimiya
- Aoi Kiriya
- Ran Shibuki
- Mizuki Kanzaki
- Kaede Ichinose
- Yurika Tōdō
- Otome Arisugawa
- Sakura Kitaōji
- Shion Kamiya
- Orihime Mitsuishi
- Johnny Bepp
- Ringo Hoshimiya
- Raichi Hoshimiya
- This is the first time someone other than Otome says her catchphrase "Love You".


text:
On Wed, Nov 18, 1998 at 11:25:59AM -0500, Avery Pennarun wrote: > > Yes. One nit: > > > > Paragraph 3b appears to essentially put patches in the public domain. I > > assume that what they intend is that they be put under the QPL. > > Hah. Don't be fooled. > > They want to be able to relicense your patches for the commercial Qt. This > isn't such a bad thing to want, and I don't think it conflicts with the > DFSG. (If they didn't require this, commercial Qt would soon fall way > behind the free one -- then Troll Tech has a problem.) The NPL has a similar bit of wording.. -- Show me the code or get out of my way.
Description: PGP signature


text:
December 21, 2010
Word around sneaker blog world is that the Air Jordan XI "Concords" will get a retro release sometime in 2011, and all things are pointing to Christmas season marking the third year that the folks at Jordan Brand ended the year with XI retro. Stay tuned for more info as we get it. Consider two or three of these officially copped.


text:
Emery Cat 3 Helpful Tips
Gutters were initially meant to maintain water flow away from a construction's basis. You will become depending on chemical substances versus having a garden can stick insects be pets the place useful bugs more or less care for much less useful ones. This machine is capable of driving away bugs and pests like spiders, fleas, ticks and cockroaches nearly immediately.
Keep in mind that you should not catch and feed your pet tarantula with bugs directly from the wild to keep away from the chance of endangering them with pesticides and different toxins. Make positive that gutters are stored free from particles and hold the grass in your garden quick. Though pest management can discuss with coping leaf insects as pets with pest birds, bugs, and rodents, this text will deal with eliminating insects. The only distinction is that you are not exposing your self, your family or your pets to dangerous negative effects. This technique will fully deter these insects and give your house a lemon-fresh scent.
A few examples of these helpful vegetation are marigolds, geraniums, and lavender and are used at most of the inns in Carmel, CA. These flowers are neither dangerous insects as pets australia to your pets or your children, so that they do nothing but maintain your beautiful gardens.
If the identical vegetable is planted in the identical spot the following yr, the diseases and bugs will emerge from the soil and assault the brand new crops. There are many good cures for keeping ants from places you don't want them in however since they've already made their method into your pantry, you need a quick and effective manner of driving them lemon use and water, half and half. Trips with Pets has much insects as pets australia more tips, pet travel advice, and pet pleasant resorts to make it possible for the one that you love pooches are secure and pleased irrespective of the place your travels take you. Spreading sand over the area is instrumental as the bugs cannot be capable to tunnel although it.
Cat grooming consists of the practices like kitten care, giving hygiene tub, cleaning, combing, brushing, checking ears, paws, tooth & underside, nail cutting, removing cat fleas & insects and fixing common meeting with a professional veterinary. When the cats die you should buy cat urn to memorialize and overlook the mental agony resulting insects as pets in japan from perennial absence of the cat. In households the place pets are free to roam, sleep and eat inside, be sure that your pet is lice-free. Termites, which are wooden-destroying insects frequent in most areas of Australia, trigger many millions of dollars of harm yearly.
Author: Dilan BeliThis author has published 2445 articles so far. More info about the author is coming soon.


text:
Job Title: Volume Sales Agent (VSA)
- To help generate qualified leads and sell real estate products and services pan Nigeria.
- The ideal candidate should have flair in sales and marketing.
- Sells products by leveraging on their social contacts and as well establishing new contacts and developing relationships with prospects.
- The VSAs is expected to qualify and contact prospective clients and close deals.
- Should be available to attend sales storming, events and training's to improve knowledge. Generate prospects pipeline as well as daily and weekly sales reports to team lead.
- Maintains relationships with clients by providing after sales support, information and recommending new opportunities.
- Accompany buyers during visits to and inspections of property.
- Minimum of one year of sales experience.
- Experience in real estate sales is an added advantage.
- Individual with excellent communication and persuasive skill, highly confident and goal oriented.
- OND, HND & B.Sc. in any discipline.
- Must be residing in Lagos.
Location: Nigeria
Closing Date
15th November, 2016.
Method of Application
Interested and qualified candidates should forward their CV's to: email@example.com


text:
Atif Aslam Covers The Legends Mohammad Rafi Kishore Kumar YouTube MP3
Atif Aslam singing old songs unplugged MP3
awesome cover by atif of ald songs..unplugged..(me pal do pal ka shayar hu,kabhi kabhi mere dil me,mera geet amar,door jab din dhal jaye,kya hua tera wada ...
atif aslam old songs acoustic best compilation.mp3 MP3
Atif Aslam - Old Songs| Unplugged. MP3
Atif Aslam - Old Songs| Unplugged.
Pyar Deewana Hota Hai - Kati Patang - Rajesh Khanna, Asha Parekh - Superhit Old Hindi Song MP3
Watch this super hit romantic old Hindi song Pyar Deewana Hota Hai sung by Kishore Kumar from classic blockbuster film Kati Patang (1970) starring Rajesh ...
Sonu Nigam - Kya Hua Tera Vada - An Evening In London MP3
Watch Sonu Nigam Performing Live at ''An Evening In London'' Concert. Song Name - Kya Hua Tera Vada Music Composer - R D Burman Lyricist - Majrooh ...
Atif Aslam And Sonu Nigam Jugalbandi's Official Video !!! MP3
Watch Atif Aslam And Fawad Khan Talking About India And Bollywood - https://www.youtube.com/watch?v=tEE4IGpdO4w.
Romantic medley tribute to Shahrukh Khan by Bollywood Singers | Mirchi Music Awards MP3
Missed out on watching the act performed by the veterans and the newbies as they pay a tribute to the the King Of Romance, King Khan on the stage of the 6th ...
Gulabi aankhen jo teri dekhi - Unplugged cover by Atif Aslam. MP3
Song: Gulabi aankhen jo teri dekhi. Artist: Atif Aslam.
Live concert atif alsam and sonu nigam MP3
Atif and sonu singing together for the first time ever on same stage.
Mirchi Music Awards 2013- Rajesh Khanna Hit songs With Sonu Nigam MP3
Mirchi Music Awards 2013- Rajesh Khanna Hit songs.
Tribute to Jagjit Singh by Sonu Nigam MP3
Tribute to Jagjit Singh by Sonu Nigam.
Atif Aslam - Pyaar Deewana Hota Hai MP3
A Tribute to ATIF ASLAM.
Pyar Diwna Hota Hai | Atif Aslam | Full Audio Song 2016 Unplugged MP3
Here we present you the latest single from atif aslam "pyar diwna hota hai" from the movie kati patang, the original track was sung by kishore kumar. now enjoy ...
atif aslam suno kisi shayar ne MP3
Atif Aslam's Gulabi Ankhein ( Unplugged Cover )'s Lyrics MP3
Originally Singed By Legendary Mr Muhammad Rafi Download Link In Mp3 Format ...
Zindagi ke safar mein (covered by Atif Aslam) MP3
cover of Kishore Kumar's song sung by Atif Aslam in an interview (better quality)
Pyar diwana hota hai by Atif Aslam 2011 - HQ By Aadeez Lovers !! MP3
Atif Aslam Singing the best song old song of Kishore Kumar ....
Atif Aslam on K for Kishor MP3
its a special appreance on sony \TV by atif aslam.


text:
If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
Learn more about our returns policy
Description: At the heart ofThe Republic of Loveare the voices of three musiciansqueer nightclub star Zeki Muren,arabeskoriginator Orhan Gencebay, and pop diva Sezen Aksuwho collectively have dominated mass media in Turkey since the early 1950s. Their fame and ubiquity have made them national iconsbut, Martin Stokes here contends, they do not represent the official version of Turkish identity propagated by anthems or flags; instead they evoke a much more intimate and ambivalent conception of Turkishness. Using these three singers as a lens, Stokes examines Turkey's repressive politics and civil violence as well as its uncommonly vibrant public life in which music, art, literature, sports, and journalism have flourished. However, Stokes's primary concern is how Muren, Gencebay, and Aksu's music and careers can be understood in light of theories of cultural intimacy. In particular, he considers their contributions to the development of a Turkish concept of love, analyzing the ways these singers explore the private matters of intimacy, affection, and sentiment on the public stage.
Limited time offer:
Get the first one free! (?)
All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.
List price: $35.00Copyright year: 2010Publisher: University of Chicago PressPublication date: 10/1/2010Binding: PaperbackPages: 280Size: 5.75" wide x 8.75" long x 0.50" tall Weight: 0.682Language: English
*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost®
and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but
is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes
Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace"
orders are not eligible for free or discounted shipping.
Learn more about the TextbookRush


text:
David O. Norris
LOCATION: Boulder, CO, United States
Professor of Biology, University of Colorado, Boulder. Author of Vertebrate Endocrinology.
Primary Contributions (1)
any of the systems found in animals for the production of hormones, substances that regulate the functioning of the organism. Such a system may range, at its simplest, from the neurosecretory, involving one or more centres in the nervous system, to the complex array of glands found in the human endocrine system. Comparative endocrinologists investigate the evolution of endocrine systems and the role of these systems in animals' adaptation to their environments and their production of offspring. Studies of nonmammalian animalshave provided information that has furthered research in mammalian endocrinology, including that of humans. For example, the actions of a pituitary hormone, prolactin, on the control of body water and salt content were first discovered in fishes and later led to the demonstration of similar mechanisms in mammals. The mediating role of local ovarian secretions (paracrine function) in the maturation of oocytes (eggs) was discovered in starfishes and only later...


text: A list of all of our accommodation: Click on these and take a tour of all of our houses. You will see exactly what each has to offer and where it is located. Please take time to visit the 'ABOUT US' page where you may find out about our driving philosophy and what we are trying to achieve.


text:
Join as a member. There's a certificate with your name on it.
I got a D7 website to take care of. Since the website is still "in charge" of the old/current/outside web development company, I don't want to do anything on the production website to avoid any possible conflict with the web development company.
I installed copy of the website on my localhost and trying to figure it out what they were doing. The website is rather complex with tons of content types, webforms and custom modules.
Anybody already had exact or similar experience with taking over a website? Any tips and trick would be appreciated.
Thanks for any help.
You'd be doing yourself a
You'd be doing yourself a favor by getting a book on Drupal and going through it. A book on Drupal will give you the basic concepts, and probably introduce you to some of the well used modules. After you have read it, you will likely have a much better understanding of what you are looking at than you do now.
Checkout my Japan podcasts.


text:
General enquiries
+44 (0) 20 7079 4399
Call HCA from 8am-8pm Mon-Fri and 9am-5pm Sat
HCA Healthcare UK
Our Specialists
Dr Shabbir Moochhala
BSc (Hons), MBChB, MRCP (Edin), PhD
Nephrology, General Medicine
General nephrology, Metabolic kidney diseases, Kidney stone disease, Urinary tract stones, Electrolyte disorders, Hypertension, Renal tubular diseases.
Dr Shabbir Moochhala qualified in 1998 from the University of Edinburgh in medicine, with a first class intercalated Honours degree in Pharmacology. He gained Membership of the Royal College of Physicians of Edinburgh in 2001. His higher training in renal medicine and general (internal) medicine was based at the Freeman Hospital, Newcastle upon Tyne. His research into the renal molecular physiology of kidney stone disease was funded by a personal Fellowship from the Wellcome Trust. This research led to his PhD thesis: 'What is the function of the ANKH protein in the kidney'' (Institute of Cell and Molecular Biosciences, University of Newcastle upon Tyne, 2010). Dr Moochhala now leads a clinical research programme to find new ways in which to reduce the recurrence of kidney stone formation in patients. Dr Moochhala's clinical interests are in all aspects of kidney disease, and in addition he can provide a full service as an accredited general physician. His special interests are in the metabolic evaluation of kidney stone disease, electrolyte (body salt) disorders, hypertension and diseases of the renal tubule.
© copyright 2008 - 2017 HCA Healthcare UK.
Registered Name: HCA International Limited; The part of the UK in which it is registered: England and Wales;
Registered Number: 03020522; Registered Office Address: 242 Marylebone Road London NW1 6JL.
£500m has been invested by HCA International in the latest medical technologies and facilities over the last 10 years.
Your hospital will be one of our world-class private hospitals: HCA's world-class hospitals are accredited by The CHKS Accreditation Unit, a leading provider of healthcare intelligence and quality improvement services. The accreditation is a measure of the overall quality of a hospital and hospitals with CHKS accreditation have been shown to provide a better quality of service.
Your safety will be protected because we have more critical care beds than any other private hospital group: HCA hospitals achieved 100% compliance with all Care Quality Commission inspected outcomes of care in 2011.
Your treatment will be undertaken using the most advanced diagnostic and treatment facilities: Oliver Wyman, Corporate Accounts: Driving quality and value, January 2012.


text:
Nami Psp Wallpaper no text by Beckem88Watch
©2011-2017 Beckem88
As someone said to me here is a new version of Nami's wallpaper for PSP. Now without text.
Here it is the old version --> [link]
Here it is the old version --> [link]
Is there a chance I can get a 1920 x 1080 version?
Is there a larger version?
Is there a larger version?
well done bro, excellent finish!!
hey thx ,for the v3 can you remove the vertical lines at the right top part???
wow i wish i had a psp..
So Sexy
Dude, this seriously rocks!
this is so going on my psp screensaver >P
Sexy ^^
WOW sooo hot


text: 4-3 Weakside Defensive End List Using Ourlads 2014 Draft Guide as the primary resouce... I'm only listing prospects who seem to have the capability to play the weakside defensive end spot in a 4-3 defense... some may argue that some of the prospects listed can't– and that's OK too. This type of player would or should have the following qualifications: 1. A history in college of being able to get sacks. If they don't have the pedigree as someone who can sack the QB in college, then they probably aren't someone the Cowboys should be interested in. 2. Speed over bulk. This player's first responsibility is to rush the QB and not hold the edge vs the running game. Strength takes a back seat to speed. Agility figures into this too. Anyway on to the list: 1. Jadeveon Clowney, South Carolina- 6'5" 266lbs 4.53 forty. Top 5 pick. 2. Anthony Barr, UCLA- 6'4" 255lbs 4.59 forty. 1st round. 3. Trent Murphy, Stanford- 6'5" 250lbs 4.85 forty. 1st/2nd round. 4. Dee Ford, Auburn- 6'2" 252lbs 4.56 forty. 1st/2nd round. 5. Jeremiah Attaochu, Georgia Tech- 6'3" 252lbs 4.65 forty. 2nd/3rd round. 6. Marcus Smith, Louisville- 6'3" 261lbs 4.68 forty. 2nd/3rd round. 7. Chris Smith, Arkansas- 6'1" 266lbs 4.71 forty. 2nd/3rd round. 8. Jackson Jeffcoat, Texas- 6'3" 247lbs 4.63 forty. 3rd/4th round. 9.Demarcus Lawrence, Boise State- 6'2" 251lbs 4.82 forty. 3rd/4th round. 10. Trevor Reilly, Utah- 6'4" 247lbs 4.67 forty. 4th/5th round. 11. Cassius Marsh, UCLA- 6'4" 252lbs 4.86 forty. 4th/5th round. 12. James Gayle, Virginia Tech- 6'3" 259lbs 4.68 forty. 4th/5th round. 13. Adrian Hubbard, Alabama- 6'6 257lbs 4.68 forty. 5th/6th round. 14. Larry Webster, Bloomsburg- 6'5" 252lbs 4.58 forty. 5th/6th round. 15. Shaquil Barrett, Colorado State- 6'1" 260lbs 4.75 forty. 6th/7th round 16. Zach Moore, Concordia-St. Paul- 6'5" 269lbs 4.79 forty. 7th round/PFA 17. Chidera Uzo-Diribe, Colorado- 6'2" 252lbs 4.65 forty. 7th round/PFA 18. Kasim Edebali, Boston College- 6'2" 253lbs 4.79 forty. 7th round/PFA


text:
Reflective Stickers
Reflective Stickers are a fun and colorful way of making your bike look awesome whilst providing extra safety. Attach the stickers to your bike or helmet.
1. Clean the surface where you want to mount your sticker.
2. Peel off the sticker and put it on.
8 large stickers
4 small stickers
3M Scotchlite Reflective Graphic Film
Shipping method is chosen after you enter your payment details but before you confirming your order. All orders are fulfilled at our warehouse in Stockholm, Sweden within 3 business days.
The shipping cost for untraceable post service is €4 (outside EU)/€5 (inside the EU).
EU - Free Express shipping on all orders over €50.
Orders are shipped with UPS Express Saver. Delivery within 2-4 working days after fulfillment.
Sweden - Free Express shipping on all orders over €25.
Orders are shipped with DHL Servicepoint. Delivery within 1-2 working days after fulfillment.
Australia/Asia - Free Express shipping on all orders over €55.
Orders are shipped with UPS Express Saver. Delivery within 2-4 working days after fulfillment.
Rest of world - Free Express shipping on all orders over €50.
Orders are shipped with UPS Express Saver. Delivery within 3-5 working days after fulfillment.
If you have any questions about orders, shipping or related topics please contact us at email@example.com.
All Bookman products are warranted to be free from any defect in materials and workmanship for a period of 2 year from the date of purchase identified on the sales receipt. Our warranty applies when our product is used for the purpose intended, under normal conditions, and does not apply to damage caused by typical wear and tear, accidents, acids, water, misuse or neglect and is limited to the value of the product. This warranty applies in addition to your statutory rights in relation to your country.
All returns will be subject to inspection and approval by Bookman or our distributor in your country before any repair or replacement is authorised.
How to Return or Exchange your Bookman Products
For warranty claims contact your place of purchase. If they are unable to help you or you bought the product at bookman.se send an email to email@example.com with your contact details, products name and place of purchase and a description of the problem. Then ship the products accompanied by the original invoice to the address below and we will exchange the product for you:
Attn: Warranty
Bookman AB
Ynglingagatan 5
113 47 Stockholm


text:
With great hope and genuine pride, the church begins this new year with a celebration of Mary, mother of Jesus, proto-disciple and model of strength, grace and courage for all believers. In his Christmas Eve homily in 1978, Salvadoran Archbishop Oscar Romero affirmed the important role of Mary in God's plan of salvation.
She is "the human instrument, the daughter of Adam, the daughter of Israel, a people's embodiment, sister of our race. ... The truest homage that a Christian can make to Mary is, like her, to make the effort to incarnate God's life in the fluctuations of our fleeting history" (The Violence of Love, The Plough Pub. Co., 1998).
Wherever she is mentioned in scripture, Mary is represented as an exemplary disciple, that is, as one who hears the word of God and keeps it (Luke 11:21). The process of hearing God's word and translating it into words and actions requires lifelong effort, and Luke gives us a clue as to how that effort began for Mary. In today's Gospel, the evangelist tells his readers that "Mary kept all these things, reflecting on them in her heart." Literally translated, the Greek verb symballein means "to toss things together in one's heart."
Mary's pondering was not unique to her. Joseph's father did the same when his son shared a revelatory dream with him (Gen 37:1). When Daniel interpreted Nebuchadnezzar's dream, the Babylonian king "kept with concern these things in his heart" (Daniel 4:28; 7:28). In the intertestamental Testament of Levi (6:2), Levi had a similar reaction when an angel opened heaven's gate and allowed him to see God's throne. These references, according to Raymond E. Brown, suggest an apocalyptic rather than a historic underpinning to the infancy narratives (The Birth of the Messiah, Doubleday, 1979). An angel-messenger has proclaimed the day of salvation, a sign has been given, heavenly hosts have appeared, and Mary, for whom these events must have been puzzling, kept everything in her heart.
Brown has also identified the wisdom tradition present in Mary's action. Mary was like the scribe of Sirach 39:1-3 who kept with concern the parables, prophecies and mysterious sayings, reflecting on them in order to comprehend and live by them. As the wise man taught his son and urged him, "Hold my words in your heart" (Proverbs 3:1), so did Mary. Like the psalmist who said to God, "I have hidden your sayings in my heart so that I may not sin" (Psalm 119:11), so said Mary.
Most scholars agree that full comprehension of all that she held and "tossed about" and interpreted in her heart came much later for Mary. Only in time did she begin to fully appreciate the words of the angel messenger as well as those of Simeon, Elizabeth, Joseph, John and even Jesus. Her greatness lies in her willingness to go forward with a plan she did not understand, to a place she had not chosen, for the sake of a people who would reject and torture and kill her son.
By virtue of her position in God's plan of salvation and her willingness to remain "pregnant" with words and signs and purposes that would only later come to light and fruition, Mary is an able guide for all who venture into this new year. Emulating her and the Son she brought into the world, we can rejoice with Paul (Galatians, second reading) in the fact that we too are God's children, near and dear enough to call God "Abba," "Papa," "Daddy." With Mary, we and all who believe enter into 2012 with the blessing from Numbers (first reading) to encourage and strengthen us. Like Mary, we hold this blessing in our hearts, allowing it to gestate there along with the echoes of the sacred texts that will inspire and guide us through the year. As events unfold, as people come and go in our lives, we will consider each of them in light of our sacred cache. Like Mary, we will keep all these things, reflecting on them in our hearts.
[Patricia Sánchez holds a master's degree in literature and religion of the Bible from a joint degree program at Columbia University and Union Theological Seminary in New York.]
NCR Comment code: (Comments can be found below)
Before you can post a comment, you must verify your email address at Disqus.com/verify.
Comments from unverified email addresses will be deleted.
- Be respectful. Do not attack the writer. Take on the idea, not the messenger.
- Don't use obscene, profane or vulgar language.
- Stay on point. Comments that stray from the original idea will be deleted. NCR reserves the right to close comment threads when discussions are no longer productive.
We are not able to monitor every comment that comes through. If you see something objectionable, please click the "Report abuse" button. Once a comment has been flagged, an NCR staff member will investigate.
For more detailed guidelines, visit our User Guidelines page.
For help on how to post a comment, visit our reference page.
Commenting is available during business hours, Central time, USA. Commenting is not available in the evenings, over weekends and on holidays. More details are available here. Comments are open on NCR's Facebook page.


text:
Expression of proto-oncogene
Tumor tissues and matched peripheral blood samples collected from meningioma patients were used for detailed molecular analyses. KIT expression was ascertained immunohistochemically and validated by immunoblotting.
Contrary to earlier reports, KIT expression, was detected immunohistochemically in 20.6% meningioma cases (n = 34). Receptor (
This study clearly demonstrates KIT over-expression in the human meningiomas. The data suggest that up-regulated
Genetic alterations causing deregulated expression of oncogenes and tumor suppressor genes underlie most of the neoplastic events. Receptor tyrosine kinases (RTKs) constitute a discrete category of oncogenes and are integral molecules of signaling cascades. Their aberrations and deranged cross-talks lead to pathological conditions
Aberrant KIT expression is reported in gastrointestinal stromal tumors (GISTs), acute myeloid leukemia (AML), small cell lung carcinoma, breast cancer, gliomas and neuroendocrine tumors
Meningiomas are mesenchymal tumors originating from the meninges. Based on the degrees of malignancy, these tumors are graded as benign (WHO grade I), atypical (WHO grade II) and anaplastic/malignant (WHO grade III)
Meningiomas have been reported to lack KIT expression in three independent studies
Despite reported absence of KIT expression in meningiomas, our initial observation of its mRNA expression (by RT-PCR) in some cases (Additional file
Additional file 1
Figure S1. Detection of
Click here for file
Sample collection
The protocols followed in the present study were approved by both, the National Institute of Immunology's Institutional Human Ethics Committee and the Max Healthcare Ethics Committee. A series of 34 patients operated consecutively for primary intracranial meningiomas during May 2008-August 2009 at the Max hospital's Neurosciences department was included in this study. Parts of the resected tumor tissues and matched peripheral blood samples were collected from meningioma patients with their written informed consents. The samples were taken at the first diagnosis of meningioma without further selection. Histopathological examination and grading of tumors were performed following WHO guidelines 2007
Isolation of genomic DNA, total RNA and cDNA synthesis
DNA extraction kit (Qiagen, Valencia, CA, USA) was used to isolate DNA from peripheral blood leukocytes (PBLs) as per the manufacturer's protocol. Tumor tissue portions collected in RNA
Additional file 2
Table S2. Details of the primers used.
Click here for file
Immunohistochemical staining
Serial sections of formalin fixed paraffin embedded (FFPE) tumor tissues used for histopathological diagnosis were evaluated for KIT expression using immunoperoxidase-diaminobenzidine (HRP-DAB) staining. Differences in KIT expression in other types of cancers have been attributed to properties of the antibody and staining procedure used for IHC. Therefore, in the present study anti-human KIT antibody from DAKO (A4502), reported to have higher sensitivity was used
Cases, where adequate tumor tissues were available, the IHC findings were confirmed by western blotting. For this, tumor tissues were lysed in RIPA lysis buffer and separated by centrifugation. Commercially purchased total proteins of relevant non-neoplastic tissues were used as controls (Biochain). After resolving the proteins on 12% SDS polyacrylamide gels, they were transferred onto nitrocellulose membranes (Millipore, Billercia, MA, USA). The membranes were blocked in PBS buffer supplemented with 3% non-fat dried milk and 2% BSA (Cell Signaling Technology, Boston, MA, USA). Membranes were probed using polyclonal rabbit anti-human KIT (A4502, DAKO, dilution 1:1500) and polyclonal rabbit anti-Beta Tubulin (RB-9249-P1; Neo Markers, Thermo Fisher Scientific, Fremont, CA, USA, dilution 1:10,000) as primary antibodies. The proteins were detected using horse-radish peroxidase conjugated goat anti-rabbit antibody (111-036-045, Jackson Immuno Research Laboratories Inc., West Grove, PA, USA, dilution 1:10,000) and immobilon western chemiluminescent HRP substrate (Millipore).
Real-time quantification of
Primers for the genes of interest (GI) and reference (GR) were designed using Primer Express 3.0 software (ABI). Specificity of the primers was confirmed by blastn algorithm of the BLAST program.
Copy number assessment of
Copy number of
Dual-colour FISH was performed to evaluate
The slides were viewed on a BX51microscope (Olympus) and approximately 200 non-overlapping tumor-cell nuclei were evaluated from each case. U-TV1X-2 camera fitted on the microscope and CytoVisionTM and GenusTM imaging softwares (Applied Imaging, CA, USA) were used to capture the images. A
Additional file 3
Figure S2. Agarose gel pictures verifying identity of the BAC clone RP11-586A2. PCR amplification for establishing the identity of BAC clone using primers specific to: (A) cytoplasmic; (B) transmembrane and (C) extracellular domains of the
Click here for file
Genomic sequence analysis of
Based on relevant literature review,
Statistical analysis
Sigma Plot 11.0 (Systat Software Inc., Germany) was used to analyze frequency tables employing
KIT immunoexpression is detected in the neoplastic meninges
KIT immunopositivity was detected in 20.6% (7/34) meningioma cases (Table
Figure 1
Immunoexpression of KIT in meningioma and control samples.
Immunoexpression of KIT in meningioma and control samples. (A-G) Immunohistochemical staining results (A) GIST (positive control) showing strong immunopositivity with membranous staining (black arrow), (B) an otherwise KIT negative meningioma showing interspersed positive mast cells (red arrows) representing an internal control, (C) meningothelial meningioma (M10) showing weak granular cytoplasmic staining, (D) transitional meningioma (M14) displaying moderate focal staining, (E) a meningothelial meningioma (M15) with weak to moderate cytoplasmic KIT staining, (F) fibroblastic meningioma (M21) showing strong staining of the cytoplasm, (G) an atypical meningioma (M29) with strong cytoplasmic KIT expression. (H) Immunoblots of neoplastic and non-neoplastic (NN) tissue lysates, probed with antibodies to KIT and β-Tubulin.
Specificity and sensitivity of the anti-KIT antibody and efficacy of the staining protocol were confirmed by the relevant staining patterns observed in the characterized KIT positive and negative control tissues. GIST showed a promisingly strong KIT immunostaining in the cytoplasm with foci of membranous staining (Figure
In the present study, heat maps were generated using Euclidean distance and complete linkage to hierarchically cluster meningioma cases based on ΔCt values of
Figure 2
RT-qPCR estimation of
RT-qPCR estimation of
KIT immunopositivity was significantly associated with up-regulated transcript levels in meningioma (p < 0.001 for pair wise comparison, Figure
A possible correlation of FISH and qPCR amplification
To determine whether an increase in the
Additional file 4
Table S2. Copy number status of
Click here for file
Figure 3
Copy number status of
Copy number status of
Sequencing of
Analysis of
Figure 4
Electropherograms displaying mutation screening of
Electropherograms displaying mutation screening of
Figure 5
Summary of
Summary of
The variant was observed along with the normal allelic nucleotide in the electropherograms of tumor tissue and matched blood sample of the corresponding patient (Figure
Contrary to earlier reports of absence of KIT expression in meningiomas, the present study showed its expression in 20.6% cases
We selected the anti-KIT antibody (DAKO) over other commercial antibodies based on its wide spread usage by different groups working on closely related fields
Graded co-expression of KIT and Zonulin (marker for degraded blood brain barrier) in different grades of brain tumors (5 GBMs and one case each of astrocytoma WHO III and meningioma WHO III) was reported earlier
Remarkable concordance was observed between KIT immunoexpression and elevated
M541L substitution observed in the transmembrane domain in a solitary meningioma case (M16) has also been reported amongst healthy individuals
Taken together, it would be of interest to pursue whether the enhanced KIT expression in subset of meningioma cases acts as a catalyst in, complicit to or as a consequence of the meningeal neoplastic process. Further, it would be vital to determine whether KIT immunopositive meningioma cases, indeed have an activated oncoprotein. Owing to insufficient quantum of resected tissues, this aspect could not be pursued during the present study. Also, due to varying incidence rates of meningioma grades/sub-types, patient accrual and sample collection are slow processes. These limitations pose impediment for a study on fair distribution of all the pathologic subtypes.
Conclusively, contrary to earlier reports, present study demonstrates KIT immunoexpression in a subset of human meningiomas. The data suggest that over-expression of the receptor in meningioma occurs without gene amplification and is associated with transcriptional activation. Continued work in this area would help elucidate the relative contribution of deranged KIT expression to the oncogenic pathways operative in this neoplasia, thus facilitating optimization of treatment modalities.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
MS with guidance from SA and ANJ conceived and designed the study and performed the experiments. With the help of SA, MS analyzed and interpreted the molecular data. ANJ provided the patient tissues for the study. AA performed diagnosis and grading of resected tumor tissues; helped with analysis, interpretation and reporting of the immunohistochemical data and revising the manuscript. SA participated in the conception and design of the study, helped in drafting and revising the manuscript. All the authors read and approved the final manuscript.
We thank the patients and their families for consenting to participate in this study, Dr. Rajeev Tangri and Dr. Urmi Mukherjee for helping with IHC work, Dr. Sangeeta Thatai, Khem Singh Negi and Pankaj Kumar Sharma for their technical help. Equipment donation from the Alexander Von Humboldt Foundation, Bonn, Germany, is gratefully acknowledged. This work was funded by the Department of Biotechnology, Government of India Grant - BT/PR11805/MED/12/424/2009 to SA and a core grant to National Institute of Immunology, New Delhi. SA is thankful to Department of Science and Technology, Government of India, New Delhi for J. C. Bose National Fellowship. MS is thankful to DBT, New Delhi for the Senior Research Fellowship. The funders had no role in study design; in the collection, analysis and interpretation of data; in the writing of the manuscript and in the decision to publish.
Mechanisms of drug inhibition of signalling molecules
Assignment of the human c-kit proto-oncogene to the q11-q12 region of chromosome 4, using in situ hybridization
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand
Expression and function of c-kit in hemopoetic progenitor cells
Stem Cell Factor and hematopoiesis
Stem cell factor regulates human melanocyte-matrix interactions
Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses
Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization
Expression of c-kit and kit Ligand Proteins in Normal Human Tissues
C-Kit signal transduction and involvement in cancer
Hypoxia-inducible factor (HIF)-1a directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors
KIT overexpression and amplification in gastrointestinal stromal tumors (GISTs)
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors
Meningiomas in 2009: controversies and future challenges
KIT and Platelet-Derived Growth Factor Receptor Alpha Tyrosine Kinase Gene Mutations and KIT Amplifications in Human Solid Tumors
C-kit gene mutation: common and widely distributed in intracranial germinomas
Meningiomas do not express CD117 (KIT)
Phase II study of imatinib mesylate for recurrent meningiomas (North American Tumor Consortium study 01–08)
Phase II study of Gleevec(®) plus hydroxyurea (HU) in adults with progressive or recurrent meningioma
Immunohistochemistry frequently detects c-Kit expression in pulmonary small cell carcinoma
C-Kit expression in desmoid fibromatosis. Comparative immunohistochemical evaluation of two commercial antibodies
Analysis of relative gene expression data using Real-Time quantitative PCR and the 2-ΔΔCt method
Is the 1p/19q deletion a diagnostic marker of oligodendrogliomas?
c-KIT overexpression, without gene amplification, in paediatric renal tumors
9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations
Amplification of genes encoding KIT, PDGFR alpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme
CD117 expression in glial tumors
Endothelial cell KIT expression in human tumours
Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution
Are desmoid tumors kit positive?
Expression of Zonulin, c-kit, and Glial Fibrillary Acidic Protein in Human Gliomas
Coexpression of stem cell factor and its receptor c-kit in human glioma cell lines
Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor
KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes
Analysis of human p53 proteins and mRNA levels in normal and transformed cells
Identification of a polymorphism in the transmembrane domain of the proto-oncogene c-kit in healthy subjects
Mutation analysis of c-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis
Molecular and Biochemical Analyses of Platelet-Derived Growth Factor Receptor (PDGFR) B, PDGFRA, and KIT Receptors in Chordomas
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
WINN – Charity (Blanchard) Worster, 86, wife of the late Roger Worster Sr., went home to her Lord and Savior Feb. 28, 2014, at a Howland nursing home. She was born Jan. 6, 1928, in East Millinocket, the daughter of Ernest and Olie (Smith) Blanchard.
Charity was a devoted wife, mother, grandmother and great-grandmother who enjoyed camping, fishing and traveling with her husband, especially to country music shows and bluegrass festivals as well as tending to her houseplants and flowers, and feeding the birds.
She is survived by a son, Roger Jr.; a granddaughter, Amanda and her husband, Matt; a great-grandson, Edward; and a very special former daughter-in-law, Michelle; as well as several nieces and nephews. Besides her parents, she was predeceased by her husband; a daughter; four sisters; and several relatives and friends.
Honoring Charity's wishes, there will be no visitation, with spring interment at Butterfield Cemetery, Prentiss. In lieu of flowers, donations may be made in her memory to the American Heart Association, or the Alzheimer's Association. Those who wish may sign an online register and leave written condolences at www.clayfuneralhome.com.