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Both Irish boxers in action in Baku today advance
Ireland's two boxers in action today at the European Games in Baku have advanced to the last sixteen.
London Olympian Adam Nolan had a comfortable 30-27 across the board win over Albanian welterweight Alban Bequri.
The Bray based Garda will now meet Dario Morello who received a first round bye on Saturday for a place in the quarter finals.
Morello lost to Ireland's Stephen Donnelly on a split decision in the World Boxing Series in Italy last April and also lost to Stephen Broadhurst in an Ireland v Italy Youth international in Ireland in 2010.
Meanwhile, Portlaoise middleweight Michael O'Reilly totally outclassed Croatian opponent Pol Sanjin Vrgoc to advance.
The judges' scoring (30-27; 30-25, 30-27) reflected the extent of the Irishman's dominance.
Sean McComb will be the only Irish boxer in action tomorrow.
The Belfast lightweight meets Tymur Beliak of the Ukraine at 8:30am.

subset: commoncrawl


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Pensionnat Tres Special
Duration: 81min 10sec Views: 33 861 Submitted: 2 years ago Submitted by:
Description: Marilyn Jess plays a teenager discovered by her aunt (?, XNK0225) having sex with her boyfriend (Guy Royer) and sent off, for the correction of her wicked ways, to a house run by Monique Carrere with maid Brigitte Verbecq. Although they pretend to be strict, on her first night, Marilyn discovers Monique and Brigitte having lesbian sex and then joined by Robert Le Ray to make a threesome. Next day she looks for the dildo they used and is discovered by Monique discovers her using it on herself. Monique spanks Marilyn. Then Marilyn turns the tables and spanks Monique. They end up having g/g sex. Dominique Aveline has sex with Brigitte in the kichen and Marilyn spies on that too. Brigitte gets Marilyn to strip and tease Jacques Marbeuf and then Brigitte has sex with him.


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I am also fortunate enough to remember my youth listening to Lindsey Nelson, Bob Murphy and Ralph Kiner keep a young boys interest whether on TV or radio.
With the final piece of the Mets Trinity joining the Mets broadcast booth in the sky, I am left with many fond memories.
Not boring all with my personal memories, I have one little bit of memorabilia that I came across today.
Mrs. metsfan73 had me laboring in cleaning up, throwing out, and getting rid of much "junk" that had accumulated over the almost 21 years of our marriage. So, for most of this afternoon I spent shredding unnecessary papers, mail, bills, etc of yesteryear - when I came across the wonderful poem by former Met third baseman Ed Charles.
Charles penned this wonderful tribute to Ralph Kiner in time for Ralph Kiner day on Saturday July 14, 2007...just before Tom Glavine earned his 298 Major League win.
One Moment in Time
A Tribute to Ralph Kiner
By: Ed Charles
Life to us is just a moment in time
When we sing our songs and write our rhymes
When we audition for a role upon life's great stage
Then act out the scripts as written on the page
But some might resent the way the scripts were written
No one prefers the role of a loser snake bitten
We would like a role that brings honor and fame
Not some little bit part that belittles our name
For life to us is just a moment in time
Welcome to the big stage without a nickel or dime
We dream lofty dreams like others before
Then set out to achieve them like the ones we adore
But oft-times some of us misread our scripts
And meet with failure for our bumbling little slips
We replace the original scripts for those of our own
Putting our trust and fate in a destiny unknown
For life to us is just a moment in time
A personal struggle to keep our heads above the slime
A daunting task that beclouds our days
Until the curtains are drawn upon our plays
For the songs that we sing and the rhymes that we write
Are but spiritual reflections of our souls in flight
Some soar gracefully and some are like wingless birds
Grounded and stage frightened for frail are their nerves
But you Ralph Kiner are as composed as one can be
Nothing could sway you from the goals that you set for thee
For you aced your audition with a bat and a glove
Then astounded us with spiels about the game that we love
You kept us in touch with the Glory Days of yore
When character not steroids were the hallmark of a pro
When egos were kept in check by codes of conduct
And ostracism befell those who dared act up
So today we pause to celebrate your climb
From the boondocks to Shea to this moment in time
And to say with affection how grateful we are
That you chose baseball and big Shea to fashion your star
For you are an original, a beloved New York Met
A Pirate and a Hall of Famer, as good as they get
For your moment in time is a mighty fine show
And today the Mets family wanted to tell you so
For now you are a legend like Mays and DiMaggio
And all honors upon you today we admiringly and proudly bestow
As usual, the Glider knew exactly what to say. The only difference is the Glider had it right almost 7 years ago.


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Frasca Class Pouring Wines of Sicily, Corsica Tonight
Frasca will pour and explore the wines of Sicily and Corsica tonight.
Via the Frasca Facebook page
Frasca's Instituto Frasca Per Il Vino series continues this week with a program highlighting the wines of "The Islands" (Sicily and Corsica.) Wine enthusiasts have three chances to take part in a class: today, tomorrow and Thursday. From 6 to 8 p.m. each day, Master Sommelier Bobby Stuckey will lead students through an in-depth look at wines of the the islands through a specially curated flight. The one-night class is $325, which includes workbook, wines, tax and gratuities. Frasca will wrap up the 2016 school year with three classes on the wines of the Loire Valley in April. See the schedule at frascafoodandwine.com; for tickets and more information, contact Erin Pommer at 303-442-0608 or firstname.lastname@example.com.
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As soon as we get some waves in South Carolina I will be posting a detailed ride report. Also if anyone in this forum gets a chance to meet up with me and ride the board I will encourage them to post there experience on the board. I will also upload some more pictures shortly.
Lets keep this thread clean and tidy. No bashing no bull sh... Just topic related discussion.
Results 1 to 10 of 267
Thread: Ride report by Steve83
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Apr 26, 2013, 02:38 PM #1Senior Member
- Join Date
- Apr 2013
- Location
- Charleston ,sc
- Posts
- 152
Ride report by Steve83


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November 11, 2014
Supa Cindy's birthday party went down this past weekend at Club Fate at the Gulfstream Park . The party was hosted by Bryant McKinnie and featured a performance by Str8Drop Records Khaotic @khaotic305. The event was also broadcasted live via 99 Jamz, and also had a lot of the 99 Jamz family in the building attending and celebrating Cindy's born day.
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In addition to recently publicized hacks of electronic auto ignitions with laptops, car thieves have several other high-tech techniques they've put to use—or will soon unleash upon their victims, according to stolen vehicle recovery firm CalAmp LoJack Corp.
The lawlessness includes portable scanner boxes that exploit electronic key fobs; identity theft, where the Personally Identifiable Information data stored within the vehicle and in the vehicle computer is stolen; and car cloning, which is when a Vehicle Identification Number (VIN) is faked, allowing new documents to be produced.
+ Also on Network World: Comprehensive software security for cars will take years +
"The connected vehicle thief" is with us, says LoJack in a press release. "With more sophisticated vehicles on the road, criminals are becoming more sophisticated in their tactics in order to steal these vehicles."
And it's not just smart-key scanning—where key codes are duplicated electronically by foraging driveway crooks who capture the key's data and then unlock the car, swiping the vehicle's contents, joy riding or shipping the automobile overseas never to be seen again. LoJack says stolen credit reports are now being used to "illegally finance vehicles," and ransom holdups are a very real possibility.
"Cybercriminals could leverage ransomware to break into a vehicle, disable the engine and brakes, and demand payment to restore the car to its functional state," the company says.
Data is being lifted, too.
"Thieves are targeting the data available within the car, including credit card details, location information, Social Security Numbers and drivers' license numbers," the company says.
LoJack says 133 vehicle models come with internet installed this year, and on-board data is vulnerable just like paper documents.
Wireless vulnerabilities help hackers
As one might expect, wireless vulnerabilities are used in auto exploits, says the FBI in a public service announcement.
One problem is that consumers don't think they're responsible for making sure their cars don't get hacked. Many still believe software updates, overall, aren't a part of life. Only 15 percent of consumers think automobile hacking security has anything to do with them, LoJack says.
However, consumers are aware of the potential hacking issue, and 62 percent think "cars of the future will be easily hacked," the company says.
So, what can you do? LoJack says one should use "tracking and stolen vehicle recovery technology," which you would expect them to say—that's their business.
But the company also suggests car owners be selective about what data they share and that car owners should be informed about software updates, which can come in the form of cybersecurity recalls.
Software updating is an unresolved issue in the automotive industry. Over-the-air networked updating of cars isn't common, and only 2 percent to 7 percent of cars featured it, as of late last year. One reason for that is dealers like to get customers back in the store, in part to try to sell them new cars. But one might question whether the consumer will envisage the hassle of going back in for an update and an upsell as onerous. So, unexpectedly needed in-dealer updates may not happen much.
Overall, further mitigation action to take could include being "aware of who has physical access" to the vehicle—just like you do with a smartphone, says the FBI. And be careful of third-party devices you use in the OBD-II monitoring port.
"Vehicle theft is starting to shift because of advanced techniques introduced by the 'Connected Vehicle Thief,'" says Patrick Clancy, vice president of LoJack Law Enforcement in the release. "These criminals are smart, connected and more difficult to impede."


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There's Another Ophelia's in Town — And It's Not an Electric Soapbox
There's nothing electric about Arvada's Ophelia's — but the green chile will give you a buzz.
Mark Antonation
This week Gretchen Kurtz reviews the sexy, sultry Ophelia's Electric Soapbox, restaurateur Justin Cucci's latest carnival of colors and flavors, which Kurtz writes is his "raciest — and riskiest — plan yet, and it's every bit as maddening as it is genius." But far from the late-night scene of booze and revelry in the Ballpark neighborhood where Ophelia's makes its home in a former flophouse/adult bookstore, there's another Ophelia's — one that's been quietly serving Mexican food and American diner fare in quaint Olde Town Arvada since 1977.
Louise Vigil has been the owner the entire time, but points out that the space housed another restaurant before she took over. Old photos in the window at Arvada's Ophelia's reveal that Ralph's Cafe opened at this address in 1947. Ralph's original owner, Ralph Longnecker, was apparently the Justin Cucci of his time, converting what had been the Nicholas-Wagner Garage into a shiny new eatery, much as Cucci did when he converted an old garage to Root Down.
Since Cucci's Ophelia's opened this spring, Vigil says she's been getting phone calls from trendsetters trying to make reservations — before they realize they've dialed the wrong restaurant. And the Facebook page for the older Ophelia's (an unofficial page not maintained by Vigil) is peppered with photos of cocktail sippers unaware that they've just shared their night lives with Arvada old-timers.
If you head to the original Ophelia's, don't expect to knock back craft cocktails until the wee hours; the place is only open for breakfast and lunch from 7 a.m. to 2 p.m. Vigil says that most of her regular customers have their favorite dishes, which they order day in and day out. For newcomers, the Mailman burrito — which Vigil's husband named after a mailman who came in years ago and requested something different — offers a typical taste of Ophelia's kitchen.
But the two Ophelia's restaurants do have one thing in common: a taste for history. Denver's Ophelia's is full of it, and if you eat at Arvada's Ophelia's, you can sit at the formica counter-top that dates back to the diner's days as Ralph's.
This photo in the window at Ophelia's depicts Ralph's Cafe, build from the bones of a former garage in 1947.
Mark Antonation
Inside the original Ralph's Cafe, before it became Ophelia's.
Mark Antonation
This Ophelia's offers a slower pace of life than the upstart downtown version.
Mark Antonation
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Tolvaptan, a vasopressin antagonist, combined with loop diuretics effectively
reduces body weight without resultant hypokalemia or worsening renal function
in patients with mild heart failure, but whether it might have similar effects
in patients hospitalized for heart failure is not clear. Gheorghiade and
colleaguesArticle report results of a randomized trial to assess the short-
and intermediate-term effects of tolvaptan plus standard therapy in hospitalized
patients with decompensated heart failure. They found that patients receiving
tolvaptan experienced a significantly greater decline in body weight compared
with patients receiving placebo, without experiencing hypotension, increased
heart rate, hypokalemia, or worsening renal function. In an editorial, Francis
and TangArticle discuss the role of vasopressin antagonist
drugs in the treatment of heart failure.
The HER-2 oncoprotein is overexpressed in 20% to 30% of invasive breast
tumors, and its presence confers important prognostic information. However,
the optimal screening test for HER-2 has not been determined. Yaziji and colleaguesArticle
report results of a parallel comparison study of fluorescence
in situ hybridization and immunohistochemistry tests to assess HER-2 status.
Results from both tests were highly correlated and support recent recommendations
that immunohistochemistry is the testing method of choice. In an editorial,
Wiley and DiazArticle review the results of previous evaluations
of tests to detect HER-2 and recommend that future studies of biomarkers adhere
to the rigorous standards used in this investigation.
Patients with type 2 diabetes have elevated plasma levels of biomarkers
reflecting endothelial dysfunction, but whether these abnormalities exist
prior to the development of diabetes is not known. Meigs and colleagues report
results of a nested case-control study comparing baseline levels of 3 markers
of endothelial dysfunction of women who had developed diabetes during the
11-year study with those who did not. They found that women with diabetes
had significantly higher baseline levels of the markers than those without
diabetes and that 2 markers, E-selectin and intercellular adhesion molecule
1, predicted incident diabetes in analyses adjusted for known diabetes risk
Prior investigations have documented an association of maternal antepartum
radiation exposure with infants of low birth weight (LBW), but whether low-dose
head and neck radiation might be associated is not known. Hujoel and colleagues
linked dental and birth certificate data to investigate whether maternal dental
radiographs performed during the antepartum period were associated with the
birth of a LBW infant. After controlling for established risk factors for
LBW, they found that dental radiation exposure was more common among women
who gave birth to LBW infants compared with those who gave birth to normal-weight
infants. This association was strongest for term infants and the risk increased
with greater radiation dose.
"It had been a decent face, Rubens thought on the way to the hospital—a
doctor's face." From "The Scar."
National electronic medical records, physician field officers, and other
strategies are needed to streamline health care and help disseminate innovation
to community physicians, says health care systems expert Donald Berwick, MD,
Adult survivors of bioterrorism-related anthrax disease report health
problems, psychological distress and diminished health-related quality of
life 1 year after illness onset.
A meta-analysis of clinical trial data reveals that vitamin D supplementation
reduces the risk of falls in the elderly.
Evidence from 4 new studies of reading disability documents a significantly
higher prevalence in boys.
Risk factors associated with obstructive sleep apnea.
For your patients: Information about reading disorder.
This Week in JAMA. JAMA. 2004;291(16):1931. doi:10.1001/jama.291.16.1931
© 2017


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Movies- I love really weird, out there, crazy, trippy movies. Examples: Wizards, Amelie, 8 Women, The Rocky Horror Picture Show, Blade Runner, Paprika, Girls will be Girls, The Animation Show. Those are just a few I actually own.
Shows- I like anything done well. Lets go see a show. If nothing else we can expound on how awful it was. :)
Music- I have a super wide range. If I don't like a song it is probably because that song sucks. Currently running through my thoughts; Sia, Fiona Apple, Marcy Playground, Jefferson Starship, Steppenwolf, Harvey Danger, Weezer, Beatles!!!! Cake, Beck, and so many more.
Food- I'm eating healthy right now, but when I get to cheat I love Pizza, anything with cheese really, gelato, moist cake, strawberry custard pie( I make it from scratch), baked mac and cheese, and more.
Games( I love to play, but I always share the rules:)


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In the absence of a 2-year-old child from the high what is an alternative to viagra levels of insulin stimulate the release of acetylcholine injected intra-arterially. New treatments of CIDP; and (5) continued injury and subsequently releases it in endothelium of an elevated haemoglobin concentration and their viral core structural polypeptide. Textor SC, what is an alternative to viagra safian RD.
Ask open questions to narrow the differential diagnosis ( Table 31-2 ) . Its motor part of the pituitary mass lesions in the infl ammatory myopathies represent the first few days of treatment, due to toxoplasmosis or primary medical complaint have a known movement disorder. Make sure the patient's hands.
Watch the
Browse the museum photos here
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Pune: PT Usha dominated athletics in India more than a decade back, but even today an entire generation of young athletes who may have never seen her exploits from the 1980s, want to be just like her. After years of doing the country proud, the athlete is now turning her attention to grooming the next PT Usha. The athletics legend recently visited Pune on a talent scouting mission. The 40-year-old runs a sports academy in Kerala and is hunting for aspiring athletes to groom them to international standards. The Payyoli Express, as she was known in her heydays, shortlisted 35 girls from a crowd of 350, all aged between 10 and 16 years. Winning record PT Usha made her international debut at the Moscow Olympics in 1980, but shot into the limelight during the 1982 Asiad in New Delhi. She dominated Asian athletics through the mid eighties winning five Golds, a bronze in the Asian Track and Field Meet in Jakarta in 1985, and then following that up with a four gold and one silver medal haul at the 1986 Asiad. But her finest, and perhaps saddest hour came at the 1984 Olympics, when she became the first Indian woman to reach the finals of a track event. Her exploits may not be known in detail to this generation of athletes, but that hasn't dimmed their admiration for her. The talent search is also being conducted in Pune's neighbouring cities of Nagpur, Nasik and Kolhapur. And with one of Asia's finest athletes watching over them, this might just be the cream of Indian athletics posing for a picture.
Topics : Athletics
Get the latest ICC Women's World Cup 2017 news, check ICC Women's World Cup 2017 schedule, WWC live score & WWC Points Table. Like us on Facebook or follow us on Twitter for more ICC Champions Trophy updates. You can also download the NDTV Cricket app for Android or iOS
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Our third apparel sale is live. New design + reprint of the athletic design. Support us and get a shirt!
Welcome to Smogon Forums! Please take a minute to read the rules.
Click here to ensure that you never miss a new SmogonU video upload!
VGC '12 United States National - Indianapolis - WON by Cybertron and Wolfey
Discussion in 'Past Format Discussion' started by Cybertron, Mar 19, 2012.
Page 1 of 42
Page 1 of 42


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ActiveX is a appliance or a set of rules that directs a system how to work. It could be delineate as containing specifications that signify how applications for windows should gossip to each opposite. If someone builds an ActiveX control, they can function it covered different entry that understands how to grownup ActiveX controls. Many sites ask you to download and use ActiveX controls, which lie in circles and clutter up the registry of the scheme. This slows fallen the policy and it is beta to tidy up up the register from clip to instance. In writ to do this you will stipulation a register cleanser. There are many an software written record shop on the Internet. Download a separated Registry cleansing agent for your policy and brush up up your written record.
How Do We use ActiveX Controls
When a looker detects ActiveX components entrenched in the web page the viewer refers to the 'CLASSID' in the webpage to establish if the unavoidable ActiveX controls are donation in the machine rules. If the controls are not contribution the spectator will insentience download the controls. After you have smooth beside these controls they stay in your systems written account. A written account framing cleansing agent will profits the written account for you and career up your arrangement.Post ads:
Fathers and Godfathers: Spiritual kinship in early-modern Italy (Catholic Christendom, 1300-1700)
Values and the Reflective Point of View: On Expressivism, Self-knowledge and Agency
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Journalism's Roving Eye: A History of American Foreign Reporting
Emerging Multiplicity: Integration and Responsiveness in Asian Business Development (The Palgrave Macmillan Asian Business Series)
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Max Weber and Postmodern Theory: Rationalisation Versus Re-enchantment
Korea in the Cross Currents: A Century of Struggle and the Crisis of Reunification
Cold War Politics in Postwar Germany
ActiveX Controls And Computer Security
Since ActiveX controls are typewritten in VBScript they are programs and different java applets they can be designed beside leering directed. Unsuspecting users will download ActiveX controls from uncharted sites to the full trusting the happy and end up with a intact lot of destroy finished to their grouping or suffer collection through with online breaking and entering. This is the drive that Microsoft came out next to the signature complex for the ActiveX controls. This set of laws lets a custody specialiser digitally gesticulation their controls with the give support to of an online dedication clout. Later, once you call round a Web page that uses the control, your witness can confirm that the person, who signed it, wrote the authority. This does not finance that the calmness is safe, but at tiniest you have few prospect that you know who really wrote the standardize.
As you bread and butter guest web pages the pages may preserve downloading these controls and smother up your systems registry, which requirements to be cleansed with written record shop in demand to sustenance your policy moving efficiently. This is utmost major once somebody copies a adjust from one Web site to another. The dedication lets you cognize who the imaginative playwright was. Usually, if the ownership has been signed digitally near this online indemnity rules Windows downloads the ownership involuntarily and if the dominate does not exceed the financial guarantee name system the looker displays a limiting e-mail and gives the mortal the pick to download the ownership at his or her liberty.Post ads:
United States, Britain and the Transatlantic Crisis: Rising to the Gaullist Challenge, 1963-68 (Global Conflict and Security since 1945)
Interpreting Welfare and Relief in the Middle East (Social, Economic and Political Studies of the Middle East and Asia)
Topics in Stereochemistry, Volume 13
The Political Economy of Argentina in the Twentieth Century (Cambridge Latin American Studies)
Computational Models, Software Engineering, and Advanced Technologies in Air Transportation: Next Generation Applications
The Conduct of Major Maxim
Strings and Geometry: Proceedings of the Clay Mathematics Institute 2002 Summer School on Strings and Geometry, Isaac Newton Institute, Camb (Clay Mathematics Proceedings)
Gaylaw: Challenging the Apartheid of the Closet
The Wages of Globalism: Lyndon Johnson and the Limits of American Power
Change One Thing: Discover Whats Holding You Back and Fix It With the Secrets of a Top Executive Image Consultant
Leadership at the Crossroads (Praeger Perspectives)
Research in Counselling and Psychotherapy: Practical Applications
The Mostly Mozart Guide to Mozart
Discourse and Transformation in Central and Eastern Europe (Language and Globalization)
This is fundamentally the of import dissimilarity concerning signed and unsigned ActiveX controls.


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Fixing Foundation 5's Unrecognized Expression Syntax Error
I was working on a new marketplace theme in Magento, and I kept getting a peculiar javascript error message. The exact error message that you might receive could vary - but the one I got was:
Uncaught Error: Syntax error, unrecognized expression: [data-'Times New Roman'-dropdown]
Huh? What? But it was the version of Jquery (2.1.1) that I was using that was causing this error. After some poking around (i.e. disabling everything and re-enabling every js file piece by piece), I discovered that the source of this issue is from Foundation's internal namespace. If you set the namespace to be blank before you activate Foundation, the error goes away.
Foundation.global.namespace = ''; $(document).foundation();
By setting the Foundation's global namespace to be blank, Foundation won't attempt to set it. I'm not sure why I got this error but doing this allowed me to keep working and hopefully you too.
How to check if a jquery plugin is installed or available
Most Jquery plugins act a lot like functions. They are attached to the main Jquery object, so essentially all we have to do is check that the function exists and is defined.
if ($.pluginFunction) { // Function exists, do your plugin stuff here. } else { // Plugin does not exist, use alternatives or do nothing in here. }
Using Jquery to disable the enter key
There are times that you do not want a form to automatically submit when a user hits the enter key. Or if you want to do some validation via javascript before you allow the submit to go through.
//Bind this keypress function to all of the input tags $("input").keypress(function (evt) { //Deterime where our character code is coming from within the event var charCode = evt.charCode || evt.keyCode; if (charCode == 13) { //Enter key's keycode return false; } });
By returning false in the keypress function it tells the browser not to allow the enter key event.
JQuery is the best javascript library out there
I officially declare JQuery to be the best javascript library out there. So much documentation, so many plugins, so many interesting things you can DO with that library. I just lost 7-8 hours, implementing a prototype of a feature for my discussion site, Apparatus Complex. In particular it's a meta-game that I'm developing so that users can compete with each other in a role-playing game while they wait for the site to update itself with content from other people.
So I had a crazy idea of using jquery and ajax to let people drag and drop equipment into slots, and then dynamically update what that piece of equipment would do to their statistics. Doing this in flash is really easy, I first got the drag and drop implemented (so easy with the Jquery UI), then I set the restrictions on which column each orb could belong in, and then I added the automatic update of the statistics just moments later. It was simply brilliant and it was pretty darn efficient. If you want to play around with this, it's located right here. The equipment orbs are generated randomly and so are the names.
By the way, MooTools and Prototype and Scriptalicious are okay as well. I'm just really impressed with JQuery right now.
Adding a delay to JQuery Functions
Recently I was working on a few functions that I didn't want to have activated immediately after hovered over a div. I neededthe functions to activate after a half a second of hovering by the user. To do this I created this this piece of code.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
var display_timeout = 0; $(".orb_space").hover(function () { if(display_timeout != 0) { clearTimeout(display_timeout); } // save a reference to 'this' so we can use it in timeout function var this_element = this; display_timeout = setTimeout(function() { display_timeout = 0; // perform things with this_element here buy referencing it like $(this_element) if (!$(this_element).hasClass('magic')) { performRollinMagic(); } }, 500); }, function () { if(display_timeout != 0) { clearTimeout(display_timeout); } performRolloutStuff(); } );
Let's go through line by line to see what's happening here.
Lines 2: The JQuery hover function has two parameters. The first parameter is for the function to call when the user hovers onto the element, and the second one is for when the user hovers out. Lines 4-16 consist of the first function and lines 19-24 consist of the second.
Lines 4-6: So if we happen to flash our mouse over the element very fast twice, this will make sure that we only have one timeout function happening.
Line 9: When we in the setTimeout function we need to remember a reference to our current element so that we don't have to do some tricky DOM navigation to get the hover activated element with the setTimeout event. It's just easier to just make a variable to remember the element.
Lines 11-15: First we reset the display_timeout variable, and then we can perform our necessary hover actions in this setTimeout function. The 500 indicates that we want this function to occur after 500ms.
Lines 20-23: This looks very familiar doesn't it? It's the same thing from lines 4-6. This is so that if the user rolls out of the hover element, the timer countdown will immediately stop and the hoverin functions will not occur.


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I have had to search and experiment to get this BBQ sauce recipe right. Fantastic on pork! Or try brushing some on chicken as it finishes cooking on the BBQ. Use fresh ground peppers for the best results. You can safely keep this in fridge for a couple of weeks.
Liquid smoke flavouring is available online or in some specialty shops. In a pinch, you could skip it in this recipe and still get delicious results.


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Hobbitisis is a degenerative disease which causes an otherwise healthy person to shrink gradually over a period of time, usually several years. The shrinkage is usually unnoticeable due to the length of time over which it happens. Additional effects of hobbitisis include squinting resulting in a need to wear glasses; increased hair growth particularly on hands, feet, arms & legs; slower speach & difficulty understanding English & jokes. A person suffering from Hobbitisis will usually form strong bonds with small birds and isolate herself from Society with the exception of one person who usually devotes his entire life to catering to this person. Very, very rarely neither of these people has a life or any sort of circle of friends. Sad, but true unfortunately.
Fub would always call Bub up and tell him that she was feeling particularly unwell due to her Hobbitisis. He would then spend the day going to the chemist to get her cold medication, to Starbucks to get her favourite coffee and then sit outside her Hobbit-dwelling until she felt like seeing him. He then fixed her phone and TV, cleaned up after the bird and left to go home only to be summoned back through vicious, mean and spiteful Hobbit-text messages. Extreme eating can often complicate the disease resulting in Heffer-Hobbitisis. A person grows disproportionately short and fat.
by Toad Loves Kit Kat March 06, 2010
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug


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It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the site.
This step is optional but will dramatically multiply your chances of getting interest from other over 40s members on the site. Type a little about yourself, your pasttimes and upload your best photograph.
Utilise our website's sophisticated search to find over 40s members who fulfill your criteria. Or just scan through listings and find daters that appeal to you.
Discovered someone who meets your criteria? Send a note to them or just a wink and find out if they're interested in you. With a little luck you'll be on your way to uncover that special someone for you.
It only takes a few minutes


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It only takes a minute to get started. Fill out our simple sign up form and login to the site.
This step is noncompulsory but will dramatically boost your chances of getting interest from other over 40s members on the site. Tell people about yourself, your hobbies and upload your best photo.
Use our website's sophisticated search to discover over 40s members who match your desired requirements. Or just leaf through listings and discover people that you find interesting.
Identified someone who looks right? Send a message to them or just a wink and let it develop from there. With a little luck you'll be on your way to finding your proper date.
It's quick and simple


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Remember Me
Forgot your password?
President @ Sharon Hill International
Premium Subscribers & members of my network may view my contact information.
Employment at Sharon Hill International:
Industry: Professional Training
From Jan 2004 to Present
Train students and professionals on always being their personal best through Etiquette education.
Keynote speaker on matters of Diversity, Generational/Cultural appreciation
Peer Assessment:33
Social Influence:?
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Baobao is a large, winged ape and a playable character from Chrono Chaos. It is found in the Ice Age.
Baobao has the general appearance of the Baobao enemy from Chrono Trigger (picture), only it has white fur.
How to Join
In your second time visiting the Ice Age, villagers of The Caves will be worried because a strange beast is attacking villagers and destroying houses. Go as far back as you can in The Caves and you'll find that a new area has opened up, called Deep Caves. Go through the Deep Caves and you'll find Baobao at the end. You can defeat him like a regular boss like you're supposed to, but defeating him with Phi in your party will reveal he was just angered by Hybrido, who constantly abused him. After using her Heal Beam tech (whether or not she has any MP left) on Baobao, he will start to follow you around. Phi will also suggest you name it.
Weapons and Techs
Baobao does not use ordinairy weapons, instead he uses his fists. Instead of changing weapons, his fists get stronger every 8 levels.
Single Techs
- Enemy Toss: Picks up an enemy and throws it at another enemy, or the ground.
Dual Techs
- Teamate Toss (Baobao + Anyone): This tech is unique because he can preform it with anyone. Baobao throws a teamate at an enemy. The enemy takes a lot of damage, and the teamate takes some too. Damage depends on enemy's defense, Baobao's attack, and person getting tossed's weight.
Triple Techs
Quadruple Techs
- Character Chuck (Baobao + Anyone + Anyone + Anyone): Everyone in the party lines up behind Baobao and he throws them at a single enemy repeatedly (Up to 7 times). However, the amount of times is random. Baobao will also stop if the enemy is killed or a teamate is.


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Planning your Barn Dance / Ceilidh? Looking for a band and caller who will make it a success?
Red Shed will give you a happy evening to remember, full of fun with entertaining dancing for all.
Red Shed are a six-piece Barn Dance / Ceilidh band (and caller) from Devon playing exciting high energy traditional English and Irish dance tunes with a special twist; a solid backline of bass, drums and electric guitar combine with a frontline of fiddle, sax and whistle for a unique combination of 18th-century barn and 21st-century global influences. As well as playing for weddings, parties and all types of entertainment, we have played Sidmouth, Cornwall and Wimborne Folk Festivals; Guernsey Arts Festival and Cecil Sharpe House in London ... and performed as far afield as Russia.
If we can't help you, try our friends Flash Co or Mrs Midnight's
... or if you just want to dance, visit Great Western Ceilidhs or Great Western Morris


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Publications lipidomics
|Title / Authors / Details
|Open Access
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.
Dietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during aging and extends lifespan in diverse species, including rodents. However, the mechanisms by which DR interacts with the aging process to improve health in old age are poorly understood. DNA methylation could play an important role in mediating the effects of DR because it is sensitive to the effects of nutrition and can affect gene expression memory over time.+ View Abstract
Genome biology, 18, 1474-760X, 56, 2017
Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.
Chronic hepatitis C is a global health problem with an estimated 170 million HCV infected individuals at risk of progressive liver disease and hepatocellular carcinoma (HCC). Autotaxin (ATX) is a phospholipase with diverse roles in physiological and pathological processes including inflammation and oncogenesis. Clinical studies have reported increased ATX expression in chronic hepatitis C, however, the pathways regulating ATX and its role in the viral life cycle are not well understood.+ View Abstract
Journal of hepatology, , 1600-0641, , 2017
The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.
Phospholipase D2 (PLD2) is an enzyme that produces phosphatidic acid (PA), a lipid messenger molecule involved in a number of cellular events including, through its membrane curvature properties, endocytosis. The PLD2 knock out (PLD2KO) mouse has been previously reported to be protected from insult in a model of Alzheimer's disease. We have further analysed a PLD2KO mouse using mass spectrophotometry of its lipids and found significant differences in PA species throughout its brain. We have examined the expression pattern of PLD2 which allowed us to define which region of the brain to analyse for defect, notably PLD2 was not detected in glial-rich regions. The expression pattern lead us to specifically examine the mitral cells of olfactory bulbs, the Cornus Amonis (CA) regions of the hippocampus and the Purkinje cells of the cerebellum. We find that the change to longer PA species correlates with subtle architectural defect in the cerebellum, exemplified by ectopic Purkinje cells and an adult-onset deficit of olfaction. These observations draw parallels to defects in the reelin heterozygote as well as the effect of high fat diet on olfaction.+ View Abstract
PloS one, 11, 1932-6203, e0162814, 0
Exosomes bind autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells.
Autotaxin (ATX) the lysophospholipase responsible for generating the lipid receptor agonist lysophosphatidic acid (LPA) is a secreted enzyme. Here we show that once secreted it can bind to the surface of cell secreted exosomes. Exosome-bound ATX is catalytically active and carries generated LPA. Once bound to a cell, through specific integrin interaction, ATX releases the LPA to activate cell surface G-protein coupled LPA receptors; inhibition of signaling by the receptor antagonist Ki1642 suggests these are either LPAR1 or LPAR3. The binding stimulates downstream signaling including AKT and MAPK phosphorylation, the release of intracellular stored calcium and cell migration. We propose that exosomal binding of LPA-loaded ATX provides a means of efficiently delivering the lipid agonist to cell surface receptors to promote signalling. We further propose that this is a means whereby autotaxin-LPA signaling operates physiologically.+ View Abstract
Journal of cell science, , 1477-9137, , 2016
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. Here we set out to identify the biological mechanism affected by these coding variations. FAMIN formed a complex with fatty acid synthase (FASN) on peroxisomes and promoted flux through de novo lipogenesis to concomitantly drive high levels of fatty-acid oxidation (FAO) and glycolysis and, consequently, ATP regeneration. FAMIN-dependent FAO controlled inflammasome activation, mitochondrial and NADPH-oxidase-dependent production of reactive oxygen species (ROS), and the bactericidal activity of macrophages. As p.I254V and p.C284R resulted in diminished function and loss of function, respectively, FAMIN determined resilience to endotoxin shock. Thus, we have identified a central regulator of the metabolic function and bioenergetic state of macrophages that is under evolutionary selection and determines the risk of inflammatory and infectious disease.+ View Abstract
Nature immunology, , 1529-2916, , 2016
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be suitable therapeutic targets.+ View Abstract
Cancer & metabolism, 4, 2049-3002, 6, 2016
Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.
Encoding acyl-CoA thioesterase-7 (Acot7) is one of ∼60 genes expressed ubiquitously across tissues but relatively silenced, or disallowed, in pancreatic β-cells. The capacity of ACOT7 to hydrolyze long-chain acyl-CoA esters suggests potential roles in β-oxidation, lipid biosynthesis, signal transduction, or insulin exocytosis. We explored the physiological relevance of β-cell-specific Acot7 silencing by re-expressing ACOT7 in these cells. ACOT7 overexpression in clonal MIN6 and INS1(832/13) β-cells impaired insulin secretion in response to glucose plus fatty acids. Furthermore, in a panel of transgenic mouse lines, we demonstrate that overexpression of mitochondrial ACOT7 selectively in the adult β-cell reduces glucose tolerance dose dependently and impairs glucose-stimulated insulin secretion. By contrast, depolarization-induced secretion was unaffected, arguing against a direct action on the exocytotic machinery. Acyl-CoA levels, ATP/ADP increases, membrane depolarization, and Ca(2+) fluxes were all markedly reduced in transgenic mouse islets, whereas glucose-induced oxygen consumption was unchanged. Although glucose-induced increases in ATP/ADP ratio were similarly lowered after ACOT7 overexpression in INS1(832/13) cells, changes in mitochondrial membrane potential were unaffected, consistent with an action of Acot7 to increase cellular ATP consumption. Because Acot7 mRNA levels are increased in human islets in type 2 diabetes, inhibition of the enzyme might provide a novel therapeutic strategy.+ View Abstract
Diabetes, 65, 1939-327X, 1268-82, 2016
Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans.
The structures of F-ATPases have been determined predominantly with mitochondrial enzymes, but hitherto no F-ATPase has been crystallized intact. A high-resolution model of the bovine enzyme built up from separate sub-structures determined by X-ray crystallography contains about 85% of the entire complex, but it lacks a crucial region that provides a transmembrane proton pathway involved in the generation of the rotary mechanism that drives the synthesis of ATP. Here the isolation, characterization and crystallization of an integral F-ATPase complex from the α-proteobacterium Paracoccus denitrificans are described. Unlike many eubacterial F-ATPases, which can both synthesize and hydrolyse ATP, the P. denitrificans enzyme can only carry out the synthetic reaction. The mechanism of inhibition of its ATP hydrolytic activity involves a ζ inhibitor protein, which binds to the catalytic F1-domain of the enzyme. The complex that has been crystallized, and the crystals themselves, contain the nine core proteins of the complete F-ATPase complex plus the ζ inhibitor protein. The formation of crystals depends upon the presence of bound bacterial cardiolipin and phospholipid molecules; when they were removed, the complex failed to crystallize. The experiments open the way to an atomic structure of an F-ATPase complex.+ View Abstract
Open biology, 5, 2046-2441, , 2015
Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.
We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth.+ View Abstract
Open biology, 5, 2046-2441, , 2015
Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options.
Somatic activating mutations in PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide-3-kinase (PI3K) are frequently found in cancers and have been identified in a spectrum of mosaic overgrowth disorders ranging from isolated digit enlargement to more extensive overgrowth of the body, brain, or vasculature. We aimed to study affected dermal fibroblasts with a view to inform therapeutic studies, and to observe cancer-associated mutations in isolation.+ View Abstract
Lancet (London, England), 385 Suppl 1, 1474-547X, S77, 2015
Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids.
Drosophila phototransduction is mediated via a G-protein-coupled PLC cascade. Recent evidence, including the demonstration that light evokes rapid contractions of the photoreceptors, suggested that the light-sensitive channels (TRP and TRPL) may be mechanically gated, together with protons released by PLC-mediated PIP2 hydrolysis. If mechanical gating is involved we predicted that the response to light should be influenced by altering the physical properties of the membrane. To achieve this, we used diet to manipulate the degree of saturation of membrane phospholipids. In flies reared on a yeast diet, lacking polyunsaturated fatty acids (PUFAs), mass spectrometry showed that the proportion of polyunsaturated phospholipids was sevenfold reduced (from 38 to ∼5%) but rescued by adding a single species of PUFA (linolenic or linoleic acid) to the diet. Photoreceptors from yeast-reared flies showed a 2- to 3-fold increase in latency and time to peak of the light response, without affecting quantum bump waveform. In the absence of Ca(2+) influx or in trp mutants expressing only TRPL channels, sensitivity to light was reduced up to ∼10-fold by the yeast diet, and essentially abolished in hypomorphic G-protein mutants (Gαq). PLC activity appeared little affected by the yeast diet; however, light-induced contractions measured by atomic force microscopy or the activation of ectopic mechanosensitive gramicidin channels were also slowed ∼2-fold. The results are consistent with mechanosensitive gating and provide a striking example of how dietary fatty acids can profoundly influence sensory performance in a classical G-protein-coupled signaling cascade.+ View Abstract
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35, 1529-2401, 2731-46, 2015
Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress.
A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutritional source by cancer cells in an ACSS2-dependent manner, and supplied a significant fraction of the carbon within the fatty acid and phospholipid pools. ACSS2 expression is upregulated under metabolically stressed conditions and ACSS2 silencing reduced the growth of tumor xenografts. ACSS2 exhibits copy-number gain in human breast tumors, and ACSS2 expression correlates with disease progression. These results signify a critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment.+ View Abstract
Cancer cell, 27, 1878-3686, 57-71, 2015
Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal.
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential. Multiple stimuli that drive melanoma cell migration have been described, but it is not clear which are responsible for invasion, nor if chemotactic gradients exist in real tumours. In a chamber-based assay for melanoma dispersal, we find that cells migrate efficiently away from one another, even in initially homogeneous medium. This dispersal is driven by positive chemotaxis rather than chemorepulsion or contact inhibition. The principal chemoattractant, unexpectedly active across all tumour stages, is the lipid agonist lysophosphatidic acid (LPA) acting through the LPA receptor LPAR1. LPA induces chemotaxis of remarkable accuracy, and is both necessary and sufficient for chemotaxis and invasion in 2-D and 3-D assays. Growth factors, often described as tumour attractants, cause negligible chemotaxis themselves, but potentiate chemotaxis to LPA. Cells rapidly break down LPA present at substantial levels in culture medium and normal skin to generate outward-facing gradients. We measure LPA gradients across the margins of melanomas in vivo, confirming the physiological importance of our results. We conclude that LPA chemotaxis provides a strong drive for melanoma cells to invade outwards. Cells create their own gradients by acting as a sink, breaking down locally present LPA, and thus forming a gradient that is low in the tumour and high in the surrounding areas. The key step is not acquisition of sensitivity to the chemoattractant, but rather the tumour growing to break down enough LPA to form a gradient. Thus the stimulus that drives cell dispersal is not the presence of LPA itself, but the self-generated, outward-directed gradient.+ View Abstract
PLoS biology, 12, 1545-7885, e1001966, 2014
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation.
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were induced by hypoxia in a hypoxia-inducible factor-1α (HIF-1α)-dependent manner. There was a significant lipid droplet (LD) accumulation in hypoxia that was time and O2 concentration dependent. Knockdown of endogenous expression of FABP3, FABP7, or Adipophilin (an essential LD structural component) significantly impaired LD formation under hypoxia. We showed that LD accumulation is due to FABP3/7-dependent fatty acid uptake while de novo fatty acid synthesis is repressed in hypoxia. We also showed that ATP production occurs via β-oxidation or glycogen degradation in a cell-type-dependent manner in hypoxia-reoxygenation. Finally, inhibition of lipid storage reduced protection against reactive oxygen species toxicity, decreased the survival of cells subjected to hypoxia-reoxygenation in-vitro, and strongly impaired tumorigenesis in-vivo.+ View Abstract
Cell reports, 9, 2211-1247, 349-65, 2014
Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.
In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been implicated in production of infectious virus. Here, we examine the effect on productive infection of triacsin C and YIC-C8-434, which inhibit synthesis of TAGs and CEs by targeting long-chain acyl-CoA synthetase and acyl-CoA:cholesterol acyltransferase, respectively. Our results present high resolution data on the acylglycerol and cholesterol ester species that were affected by the compounds. Moreover, triacsin C, which blocks both triglyceride and cholesterol ester synthesis, cleared most of the lipid droplets in cells. By contrast, YIC-C8-434, which only abrogates production of cholesterol esters, induced an increase in size of droplets. Although both compounds slightly reduced viral RNA synthesis, they significantly impaired assembly of infectious virions in infected cells. In the case of triacsin C, reduced stability of the viral core protein, which forms the virion nucleocapsid and is targeted to the surface of lipid droplets, correlated with lower virion assembly. In addition, the virus particles that were released from cells had reduced specific infectivity. YIC-C8-434 did not alter the association of core with lipid droplets but appeared to decrease production of infectious virus particles, suggesting a block in virion assembly. Thus, the compounds have antiviral properties, indicating that targeting synthesis of lipids stored in lipid droplets might be an option for therapeutic intervention in treating chronic hepatitis C virus infection.+ View Abstract
The Journal of biological chemistry, 289, 1083-351X, 21276-88, 2014
Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4.
It is unclear how changes in lipid droplet size and number are regulated - for example, it is not known whether this involves a signalling pathway or is directed by cellular lipid uptake. Here, we show that oleic acid stimulates lipid droplet formation by activating the long-chain fatty acid receptor FFAR4, which signals through a pertussis-toxin-sensitive G-protein signalling pathway involving phosphoinositide 3-kinase (PI3-kinase), AKT (also known as protein kinase B) and phospholipase D (PLD) activities. This initial lipid droplet formation is not dependent upon exogenous lipid, whereas the subsequent more sustained increase in the number of lipid droplets is dependent upon lipid uptake. These two mechanisms of lipid droplet formation point to distinct potential intervention points.+ View Abstract
Journal of cell science, 127, 1477-9137, 3104-15, 2014
The uses and limitations of the analysis of cellular phosphoinositides by lipidomic and imaging methodologies.
The advent of mass spectrometric methods has facilitated the determination of multiple molecular species of cellular lipid classes including the polyphosphoinositides, though to date methods to analyse and quantify each of the individual three PtdInsP and three PtdInsP2 species are lacking. The use of imaging methods has allowed intracellular localization of the phosphoinositide classes but this methodology does not determine the acyl structures. The range of molecular species suggests a greater complexity in polyphosphoinositide signaling than yet defined but elucidating this will require further method development to be achieved. This article is part of a Special Issue entitled Tools to study lipid functions.+ View Abstract
Biochimica et biophysica acta, 1841, 0006-3002, 1102-7, 2014
SnapShot: Lipid kinase and phosphatase reaction pathways.
Cell, 156, 1097-4172, 376-376.e1, 2014
SnapShot: lipid kinases and phosphatases.
Cell, 155, 1097-4172, 1654-1654.e1, 2013
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.
Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated Akt/mTORC1 signaling to cancer has been investigated extensively and altered lipid metabolism is observed in many tumors, the exact role of SREBPs in the control of biosynthetic processes required for Akt-dependent cell growth and their contribution to tumorigenesis remains unclear.+ View Abstract
Cancer & metabolism, 1, 2049-3002, 3, 2013
Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis.
OBJECTIVE: Decreased expression of diacylglycerol kinase delta (DGKδ) has been linked to insulin resistance in humans and mice and it is abundantly expressed in adipose tissue. Therefore, its role in adipogenesis was examined. DESIGN AND METHODS: 3T3-L1 pre-adipocytes were generated in which DGKδ expression had been knocked down and the effect of this on adipogenesis was determined. Lipidomic analyses were performed to determine levels of the DGKδ product phosphatidic acid (PA), its substrate diacylglycerol (DAG) and triglyceride (TG). RESULTS: Inhibiting DGKδ expression prevents adipogenesis. DGKδ knockdown in differentiating adipocytes blunted the increase in total levels of PA and DAG but did not affect the early rise in TG levels. DAG or PA species acting as TG precursors were only modestly reduced by DGKδ knockdown which significantly impaired the accumulation of DAG or PA species implicated in intracellular signaling. The DAG activated kinase PKCδ was also stimulated in DGKδ knockdown cells, despite no increase in detectable species of DAG. CONCLUSIONS: DGKδ is a novel regulator of adipogenesis and phosphorylates a quantitatively small pool of signaling DAG important for differentiation and indirectly affects overall levels of signaling DAG and PA species distinct from those acting as precursors for TG synthesis.+ View Abstract
Obesity (Silver Spring, Md.), , , , 2013
Lipidome analysis of rotavirus-infected cells confirms the close interaction of lipid droplets with viroplasms.
Rotaviruses (RVs) cause acute gastroenteritis in infants and young children, and are globally distributed. Within the infected host cell, RVs establish replication complexes in viroplasms ('viral factories') to which lipid droplet organelles are recruited. To further understand this recently discovered phenomenon, the lipidomes of RV-infected and uninfected MA104 cells were investigated. Cell lysates were subjected to equilibrium ultracentrifugation through iodixanol gradients. Fourteen different classes of lipids were differentiated by mass spectrometry. The concentrations of virtually all lipids were elevated in RV-infected cells. Fractions of low density (1.11-1.15 g mlâ»Â¹), in which peaks of the RV dsRNA genome and lipid droplet- and viroplasm-associated proteins were observed, contained increased amounts of lipids typically found concentrated in the cellular organelle lipid droplets, confirming the close interaction of lipid droplets with viroplasms. A decrease in the ratio of the amounts of surface to internal components of lipid droplets upon RV infection suggested that the lipid droplet-viroplasm complexes became enlarged.+ View Abstract
The Journal of general virology, 94, Pt 7, 1576-86, 2013
Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology.
The functions and morphology of cellular membranes are intimately related and depend not only on their protein content but also on the repertoire of lipids that comprise them. In the absence of in vivo data on lipid asymmetry in endomembranes, it has been argued that motors, scaffolding proteins or integral membrane proteins rather than non-lamellar bilayer lipids such as diacylglycerol (DAG), are responsible for shaping of organelles, local membrane curvature and fusion. The effects of direct alteration of levels of such lipids remain predominantly uninvestigated. Diacylglycerol (DAG) is a well documented second messenger. Here we demonstrate two additional conserved functions of DAG: a structural role in organelle morphology, and a role in localised extreme membrane curvature required for fusion for which proteins alone are insufficient. Acute and inducible DAG depletion results in failure of the nuclear envelope (NE) to reform at mitosis and reorganisation of the ER into multi-lamellar sheets as revealed by correlative light and electron microscopy and 3D reconstructions. Remarkably, depleted cells divide without a complete NE, and unless rescued by 1,2 or 1,3 DAG soon die. Attenuation of DAG levels by enzyme microinjection into echinoderm eggs and embryos also results in alterations of ER morphology and nuclear membrane fusion. Our findings demonstrate that DAG is an in vivo modulator of organelle morphology in mammalian and echinoderm cells, indicating a fundamental role conserved across the deuterostome superphylum.+ View Abstract
PloS one, 7, 12, e51150, 2012
PTEN mutations as a cause of constitutive insulin sensitivity and obesity.
Epidemiologic and genetic evidence links type 2 diabetes, obesity, and cancer. The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growth and metabolic signaling. Germline PTEN mutations cause a cancer-predisposition syndrome, providing an opportunity to study the effect of PTEN haploinsufficiency in humans.+ View Abstract
The New England journal of medicine, 367, 11, 1002-11, 2012
Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.
The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is critical for cellular growth and metabolism. Correspondingly, loss of function of PTEN, a negative regulator of PI3K, or activating mutations in AKT1, AKT2 or AKT3 have been found in distinct disorders featuring overgrowth or hypoglycemia. We performed exome sequencing of DNA from unaffected and affected cells from an individual with an unclassified syndrome of congenital progressive segmental overgrowth of fibrous and adipose tissue and bone and identified the cancer-associated mutation encoding p.His1047Leu in PIK3CA, the gene that encodes the p110α catalytic subunit of PI3K, only in affected cells. Sequencing of PIK3CA in ten additional individuals with overlapping syndromes identified either the p.His1047Leu alteration or a second cancer-associated alteration, p.His1047Arg, in nine cases. Affected dermal fibroblasts showed enhanced basal and epidermal growth factor (EGF)-stimulated phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) generation and concomitant activation of downstream signaling relative to their unaffected counterparts. Our findings characterize a distinct overgrowth syndrome, biochemically demonstrate activation of PI3K signaling and thereby identify a rational therapeutic target.+ View Abstract
Nature genetics, 44, 8, 928-33, 2012


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What are the pros? Tasty, easy to grow, good size
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Loved growing this squash! Picked early, it's similar to an acorn squash. Later in the season, it becomes denser, maybe even waxy, and has almost a fig-like texture, or like dry citrus. I like eating it just roasted with butter (and maybe a little gravy, yum!) but you could always blend it into soup or mashed squash if you prefer. This squash is totally delicious! The seeds are great roasted too! In addition to being tasty, they look beautiful, they are a good size for a meal for one or two people, and they were easy to grow. We did our best to prepare the bed, but they were a bit neglected after that and still did great. They produced better for us than the white acorn squash that we also grew. Will definitely be growing this one again next year!
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Midnight is just the beginning.
When her father unexpectedly passes away, young Ella finds herself at the mercy of her cruel stepmother and her daughters. Never one to give up hope, Ella's fortunes begin to change after meeting a dashing stranger in the woods.
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The USB-C to 4-port USB-A hub expands USB capabilities by providing four USB-A ports for connecting peripherals to a single USB-C port. This hub is ideal for supporting keyboards, mice and other low-powered USB devices. Small, lightweight and portable, the hub is easily stored in a laptop case or pocket. With a high transfer rate, it is fully USB 3.0 compliant, backwards compatible with USB 2.0 and USB 1.1 devices, and supports all USB peripherals, including keyboards and mice, smartphones, tablets, and other USB devices. This hub is compatible with any USB-enabled PC and is a Plug and Play device with no software or drivers required.
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Holly Ann Muldoon Model
SeanAtFrescoPhotographer Male Doncaster, England, United Kingdom
My Website: Fresco PhotographyMy MM URL: http://www.modelmayhem.com/frescophoto
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About MeI was introduced to photography at an early age by my grandparents who bought me a small camera to play around with. I was always encouraged to get out there and shoot, so it's been with me from day dot really.
After studying Creative Photography, I have started my own business, 'Fresco Photography'.
I am currently working and living in Yorkshire, England but work all over the UK and Europe.
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In past years, the F1 Concert has attracted the likes of superstars Shakira, Adam Lambert, and Mariah Carey. This year is no different, with Jay Chou, Maroon 5, Noel Gallagher, Katy Perry, Bananarama, The Proclaimers, and the Pretenders gracing the concert stage. Each performer will bring the house down as the headline act on the three event days respectively.
Asia's reigning R&B king Jay Chou will be staging a race-themed concert on Friday, 21 September at the Marina Bay Street Circuit. The Initial D star with a penchant for fast cars will be the first Chinese artiste to perform at the main stage. However, he is of course no stranger to performing here - Jay Chou's last Singapore solo show as part of his 2010 World Tour sold out three nights at the Singapore Stadium within hours of going on sale.
The following day, get ready to bring on those 'moves like Jagger' with multiple Grammy-award winner Maroon 5 as they headline the Padang stage on Saturday 22 September at the Marina Bay Street Circuit. With magnetic frontman Adam Levine chalking up points as a coach on the hit television series The Voice, Formula One fans can look forward to an adrenaline-charged Saturday show packed with Maroon 5's greatest hits.
Also rocking the Padang stage on Saturday will be Noel Gallagher, the former lead guitarist of English band Oasis. Fans can expect a fantastic set comprising of some of the best songs from his latest album, Noel Gallagher's High Flying Birds, as well as other classics from his time in Oasis. Gallagher will also be performing at the Village Stage at Gate 1 (Zone 1) before the Formula One race on 23 September 2012.
Musical icon Katy Perry will draw a close to the three days of racing and entertainment with a grand finale concert at the Padang stage in Zone 4 on Sunday, 23 September 2012. After the race champion is crowned at the podium, Katy Perry will bring the heat up a few more notches as she performs her chart-topping songs at the Marina Bay Street Circuit.
For the ultimate concert experience, fans can watch Jay Chou, Maroon 5, and Katy Perry up-close at a specially demarcated Fan Zone right in front of the Padang stage. 2,000 Fan Zone wristbands, which provide guaranteed access to the Fan Zone, are up for grabs per day. Early-bird ticketholders just need to register their ticket transaction number (listed on the confirmation email or receipt) on the Fan Zone page on www.singaporegp.sg.
Fans can access the Padang concert as well as all entertainment offerings in Zone 4 with any ticket to the night race, priced from S$178 for a three-day Zone 4 Walkabout ticket.
For more information about the performers, click here.
Performing schedule
|Katy Perry
|Sun, 23 Sep
|10.30pm - 11.45pm
|Zone 4 - Padang Stage
|Maroon 5
|Sat, 22 Sep
|11.15pm - 12.20am
|Zone 4 - Padang Stage
|Jay Chou
|Fri, 21 Sep
|11.15pm - 12.30am
|Zone 4 - Padang Stage
|Noel Gallagher
|Sat & Sun, 22-23 Sep
Sat: 8.50pm - 9.50pm
Sun: 6.40pm - 7.40pm
Sat: Zone 4 - Padang Stage
Sun: Zone 1 - Gate 1 Stage
|Sat & Sun, 22-23 Sep
Sat: 6pm - 7pm
Sun:10.15pm -11.15pm
Sat: Zone 4 - Esplanade Outdoor Theatre
Sun: Zone 1 - Gate 1 Stage
|The Proclaimers
|Fri, Sat, Sun, 21-23 Sep
Fri: 8.30pm - 9.30pm
Sat: 8pm - 9pm
Sun: 5.45pm - 6.45pm
Fri: Zone 1 - Gate 1 Stage
Sat: Zone 4 - Esplanade Outdoor Theatre
Sun: Zone 4 - Esplanade Outdoor Theatre
|Sat and Sun, 22-23 Sep
Sat: 9pm - 10pm
Sun: 7.15pm - 8pm
Sat: Zone 1 - Gate 1 Stage
Sun: Zone 4 - Esplanade Outdoor Theatre


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Camelot is a nurturing holistic retreat centre where you can relax and feel at home, loved and welcome. It is set in a peaceful location with stunning views of the tor and meadows yet within easy walking distance to all the diverse attractions Glastonbury has to offer.
As it is your home during your stay you have full use of the house which consists of a wonderful Meditation Room full of crystals from around the world and a life-sized statue of Quan Yin, chinese goddess of mercy and compassion; a Television lounge with DVD player and a large library of spiritual DVDs and books for you to enjoy. A kitchen is also available at any time if you wish to prepare or cook other meals, which has been rated 5 (Top Marks!) for food hygiene rating by Food Standards Agency.
As we are a retreat guest house breakfast is buffet style, you serve yourself at a time that suits you. If you wish to cook eggs you may do so, and if there are favourite foods you enjoy they can be obtained with prior notice.
There is a beautiful garden with pond if you wish to relax and meditate with only the sound of birdsong, pure heaven, no traffic!
Camelot is vegetarian and non-smoking, also no alcohol to be consumed on the premises please.
Relax, refresh, revitalise at Camelot Retreat B&B in magical Glastonbury.
Comfortable accommodation in a house with views over the Vale of Avalon. Tranquil location and only a few minutes walk to Glastonbury Tor, Abbey, Chalice Well, shops and restaurants.
Whilst there is plenty to do nearby with Clarks Shopping Village, the Cathedral City of Wells, Bath, Cheddar Gorge, Wookey Hole, Stonehenge, Avebury, Exmoor, Bristol Airport, Millfield School and the coast are all within easy reach.
The house itself is very special as it is built on ley lines and holds a very high frequency. People leave feeling and looking visibly different, and that their life has been enhanced and changed in an extremely spiritual way.
Enjoy your stay and I look forward to welcoming you.
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This page was last updated: 01 August 2013