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Ornithorhynchus Anatinus by mauricioestrellaWatch
©2006-2017 mauricioestrella
This is part of a comission work of the new studio I've joined with a fellow partner.
512x512 PNG and ICO formars.
Four color variations.
512x512 PNG and ICO formars.
Four color variations.
muy bueno
te pasaste
te pasaste
one word shall say it all: CUTE!!!
kawaii Those are simply gorgeous
Weird o.O *downloads*
Que buenos colores elegistes
Muy buen diseño.
Very cool!! Your skillz are uber l33t.
What program did you use to render that?
What program did you use to render that?
thanks a lot. Is not a render. Its a 2D drawing on Photoshop
Oh a Platypus! Way cool! We call it Onitorrinco in Portugal too. What a strange name though. LOL
You did a great job with this.
You did a great job with this.
Too nice! I like this little orny!
It's no ugly, it's extremely cute!!!!!
Ya compartí tu trabajo en MF
Ya compartí tu trabajo en MF
Wow nice detail!
I like it a lot. Cute, BTW.
Really funny, well done
LOL, u have such criativity funny bird lol
Muy simpatico el onitorrinco.
Well done
Thats great, mmmm i would like to theme that haha
hey, your platypus ish adorable.
i like him!
i like him!
awww, he looks like a platypus ...ish duck thingy! how cute!
Lol! Ugly kinda duck thing! That's funny
That's adorable.
looks funny
Great design, congrats...
Looking good man. And I am talking about the icons so don't try that stuff with me lol
nicely done
Be ready to see it in my dock next time
nicely done
Be ready to see it in my dock next time


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Anthem of the Seas
4 out of 5 stars
Download the FREE app and meet your ship mates!
On a 12 day cruise under the new dining plan, there are 2 formal nights. The second and the 10th nights. The Grande is no longer a formal wear restaurant. There is no MDR on the Anthem. There are 2 dining areas for my time dining and 2 more for early or late dining. They have updated menus that change daily.
Anyone know how how the formal night thing works on this cruise?
I was looking online to see how many formal nights there are on a 12 day cruise.... The generic Royal Caribbean guidance says 3. However, from what I was able to piece together, looks the the Anthem has none, but people dress up when eating at the Grand dining room.... Is this true? If so, how does that work with MTD?
The Captain of the Anthem was all over the ship. In the Diamond lounge and the Concierge Lounge, stopping by at all the restaurants. He works out in the gym daily. The Cruise Director, Dru was outstanding as was his assistant, Chris. Cabin attendants did a fabulous job everyday.
Back on the Anthem in 52 days for another 12 day cruise.
Just got off the Anthem this morning. Amazing ship. I ate at Chops, Jamie's Italian, the Grande and the American Icon 3 times each. The food and service was outstanding. This ship has a happy crew. The shows in both the main theater and in 270 lounge were unbelievable. Standing ovations nightly. The weather was the best. Sunny skies every day, smooth seas everyday. Great cruise!!!
If anyone is interested there is currently a 30% of drink package sale at 40 per night for our sailing. There is also a 50% internet sale at 8.99 per day for surf and stream, and discounts on excursions. Best prices i've seen since I booked. It says it its a weekend sale on the cruise planer!
66 days to go! Can't wait!
Read the best port reviews and tips for this cruise itinerary.
|Day 1
|Cape Liberty (Bayonne), New Jersey
|Day 2
|At Sea
|Day 3
|At Sea
|Day 4
|San Juan, Puerto Rico
|Day 5
|Philipsburg, St. Maarten
|Day 6
|St. John's, Antigua
|Day 7
|Fort-De-France, Martinique
|Day 8
|Bridgetown, Barbados
|Day 9
|Basseterre, St. Kitts
|Day 10
|At Sea
|Day 11
|At Sea
|Day 12
|At Sea
|Day 13
|Cape Liberty (Bayonne), New Jersey
A roll call is a space for members who are signed up for the same cruise (same ship & departure date) to connect.
Make friends BEFORE you sail, exchange tips on what to do onboard and in the ports and maybe even organize a shore excursion with your ship mates.

subset: commoncrawl


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Bulova Cherryhill Decorative Wall Clock - Cherry Finish- Satin Gold-Tone Bezel
This classic decorative wall clock will offer a flair of simple elegance to any room.
- Solid hardwood case with a brown cherry finish
- Satin gold bezel
- Quartz movement
- Sweep seconds hand
- Glass lens
- Measures 12 inches in diameter
We are Authorized Bulova Retailers. You will receive a brand-new, factory fresh Clock with the Bulova 1 Year US Clock Warranty.
In stock items ordered by 4pm Eastern time ship the same day.
All orders $50.00 or more qualify for FREE UPS Ground delivery. Watch orders $149.00 or more qualify for FREE UPS 2nd Day Air delivery. Please note that FREE 2nd Day Air Delivery does not apply to clocks.
FREE Batteries Included as Your Gift with Purchase
Batteries are not included by the manufacturer, but at Princeton Watches, for your convenience we'll include the batteries it requires as a FREE gift with purchase of this clock.


text:
Dow Corning Says Net Rose 14% On Lower Reorganization Costs
NEW YORK -- Dow Corning Corp., operating under Chapter 11 bankruptcy protection, said Friday its third-quarter net income rose l4%, mostly on lower reorganization costs and higher nonoperating income.
Dow Corning posted net income of $64.1 million, or $25.64 a share, up 14% from year-ago earnings of $56.4 million, or $22.56 a share.
Most Popular Videos
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OPEC Grapples With Growing Threats to Oil Deal
Next Leap for Robots: Picking Out and Boxing Your Online Order
Joseph Rago, Wall Street Journal Editorial Writer, Dies at 34


text: Hewlett-Packard was expected to unveil a PocketPC-based PDA/phone at this week's GSM conference in Cannes, according to CNet. Presumably this is the same device as the one codenamed Starfighter, mentioned by an HP product manager in Australia. Sagem and Trium have been selling similar devices in Europe since last year.


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Mohit Raina wikiMohit Raina is an Indian actor popular on television. He started his acting career with a sci-fi TV show called Antariksh and later made his bollywood debut with Mithun Chakraborty starrer film Don Muthu Swami. He is known for his lead role of Shiva in the TV series, Devon Ke Dev - Mahadev. He was last seen in a Colors popular show Chakravartin Ashoka Samrat.
Personal ProfileName : Mohit Raina
Birthday : 14 August 1982
Age : 34 years
Place Of Birth : Jammu, Jammu and Kashmir, India
Height : 5'11"
Current residence : Mumbai
Religion : Hindu
Occupation : Model, Actor
Debut movie : Don Muthu Swami
Debut Serial : Antariksh
BiographyMohit Raina was born on 14 August 1982 in Kashmir. He was brought up in Jammu where he did his schooling from Kendriya Vidyalaya, Jammu. He left Jammu after graduating with a degree in commerce from Jammu University.
As a teenager, Raina weighed 107 kg, but lost 29 kgs after he decided to participate in 2005 Grasim Mr. India contest, where he was placed among the top five contestants. Raina lives in Mumbai with his mother. He lost his father in 2011. Mohit is a proud owner of Ford Endeavour which costs between Rs. 19 lakh to Rs. 24 lakh.
Latest NewsAs per the latest reports, Life Ok is planning to bring back Devon Ke Dev Mahadev with new season. Mohit Raina has even signed the contract for the show. The production work is all set to begin this month and the shoot will start from next month.
Girlfriend/MarriageAccording to the sources, Mohit Raina is dating beautiful actress Mouni Roy who played his first wife Sati in the show Devo Ka Dev - Mahadev. Though they have not yet come out in public about their relationship but it seems they are very much in love. Mohit revealed that he will get married in 2017.
CareerMohit Raina began his acting career in 2006 with Tv show Antariksh. In 2008, he starred as JaiKishan in a comedy movie called Don Muthu Swami, starring actor Mithun Chakraborty in the lead role. He again returned to television in 2009 with another Star Plus' show called Chehra. Mohit was also a part of the TV series Bandini (NDTV Imagine). Mohit shot to fame for playing the role of Lord Shiva in the series Devon Ka Dev - Mahadev. He was also seen in the mythological drama "Mahabharat".
Early LifeMohit Raina hails from Jammu & Kashmir and is a very simple guy. His family was totally against his decision of becoming an actor, but they finally agreed and they were quite happy to see him as Lord Shiva.
He had faced struggles and had given some flops before hitting the jackpot. His father passed away two days before this role was offered to him. And he accepted it as a gift from his father.
Shows2006-07 Antariksh - Ek Amar Katha
2005 Bhabhi
2009 Chehra
2010 Bandini
2011 Ganga Kii Dheej
2011-14 Devon Ke Dev - Mahadev
2013-14 Mahabharat (2013 TV series)
2016 Chakravartin Ashoka Samrat


text: Aérospatiale Dauphin construction number 1008, original registration JA9166. StatusEdit Written off 5 June 1991 RegistrationsEdit JA9166 ReferencesEdit [1], accessed 8 December 2007 Retrieved from "http://airframes.wikia.com/wiki/S360-1008?oldid=7962" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Aérospatiale Dauphin Add category Cancel Save


text:
No approved endorsements
About Mr. Frederic Nuyts
Graduated in marketing at EPHEC, I worked 3 years in the distribution sector of as Key Account Manager, where I could acquire a solid experience in sales. I changed companies and became Account Manager in a consultancy firm specialised in the public sector. I was successively promoted there with the positions of Team Leader and Marketing Manager, where I could acquire all the experience necessary to completely manage a consultancy firm in the public markets. I was also simultaneous external consultant in the IT sector where I specialised myself especially in networks and web design. At the beginning of 2006, I launched with others associates my own company of consultance regarding public tenders, Government Exchange (Govex). www.govex.eu
If you notice offensive or incorrect information, please contact us.


text:
This is my second blog article, and it's actually an upgraded version of my older article (User blog:Ivan-G-D/My Family Tree), with modifications in 3 parts of the tree :
It's up to you to see where, if you can. :D
Those who find the upgrades can put their realisations in the comments.
Also, the main part is that the viking-looking dude has become a great-great-grandparent, as two of his great-grandchildren had twins (one's great-grandfather is the other's great-grandmother), so now he's a great-great-grandfather and a great-great-grandmother at the same time to these poor twins. :P
Also, the "Extra" part is the screenshot of my neighbourhood (by the way, it's called Wukiville) where this large family is placed. Here it is :
Enjoy. :)


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New 2017 Chevrolet Silverado 1500 LT w/1LT
- MAKE:Chevrolet
- MODEL:Silverado 1500
- BODY TYPE:Truck
- ENGINE:V-8 cyl
- TRANS:Automatic
- LOCATION:Houston
- EXT COLOR:Black
- INT COLOR:Jet Black
*Please note: we update our inventory daily. Please check with dealer to confirm vehicle availability.
Sellers Comments
Check out this 2017! Comprehensive style mixed with all around versatility makes it an outstanding pickup truck! Top features include power front seats, heated seats, adjustable pedals, and air conditioning. Smooth gearshifts are achieved thanks to the powerful 8 cylinder engine, and for added security, dynamic Stability Control supplements the drivetrain. We'd also be happy to help you arrange financing for your vehicle. Stop by our dealership or give us a call for more information.
- Manual Tilt/Telescoping Steering Column
- Wheel Locks
- Remote Vehicle Starter System
- 10-Way Power Driver Seat Adjuster
- LT Plus Package
- Federal Emissions Requirements
- 000 lbs
- LED Cargo Box Lighting
- Floor Mounted Console
- Transmission: Electronic 6-Speed Automatic w/OD
- Trailering Package
- Rear Under-Seat Composite Storage Bin
- 110-Volt AC Power Outlet
- Theft Deterrent System
- Universal Home Remote
- Texas Edition Badging
- 720 CCA/80 Amp-hr Maintenance Free HD Battery
- Power Adjustable Pedals
- Texas Edition
- Heavy-Duty Rear Locking Differential
- Engine: 5.3L EcoTec3 V8
- Polished Exhaust Tip
- Radio: AM/FM 8' Diagonal Clr Touch Nav
- Ultrasonic Rear Park Assist
- Front Pwr Reclining Bucket Seats(Flt)
- Auxiliary External Transmission Oil Cooler
- Power Sliding Rear Window
- Wheels: 20' x 9' Polished-Aluminum
- Thin Profile LED Fog Lamps
- 3.42 Rear Axle Ratio
- Integrated Trailer Brake Controller
- Dual-Zone Automatic Climate Control
- Heated Driver & Front Passenger Seats
- 3.08 Rear Axle Ratio
- SiriusXM Satellite Radio
- Wireless Charging
- Electric Rear-Window Defogger
- No information on specs available.
Vehicle Location
Lone Star Chevrolet
18900 NW Freeway
Houston, Texas 77065


text:
|Message view
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|Timo Rantalaiho <Timo.Rantala...@ri.fi>
|Re: ajax event handler with a textfield .. .
|Thu, 03 Jul 2008 04:37:18 GMT
On Thu, 03 Jul 2008, Rakesh Sinha wrote: > I tried something similar to this .. It works. ... > txtAge.add(new AjaxFormComponentUpdatingBehavior("onkeyup") { This works otherwise but does not detect cut and paste done with mouse. > The question is - can this be the fastest way of doing this... What do you mean by "fastest"? Least amount of code, most performant or some other thing? Probably you can trim your code a bit but the basic idea is like that. Instead of passing the error message around you could make your Label use a pull model. Plain javascript should be faster than Ajax, but then you obviously cannot check anything on the server side. Best wishes, Timo --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: email@example.com
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text:
Check out these cool Comfort Colors garments!
The weather outside is mighty frightening. Contact us today for your winter weather needs!
Is it football season yet? AKD is busy designing new tees for Bama Fever/Tiger Pride stores! Look for them soon!
The Civil Air Patrol's headquarters in at Maxwell AFB, Montgomery, and through our association with them we print tees for events all over the country. Here's a video showing a sea of bright orange tees we printed for a CAP event where schoolkids learn about engineering and aviation!


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The price of the futures on the American stock index S&P500 returned to the important level of 2120 and fixing of quotations above this level will be the basis for the continued growth of quotations to 2150 and 2200. The signal about changing the positive trend will be breaking through the lower boundary of the rising channel and fixing the price below 2090. Our medium-term outlook remains positive and we expect increased volatility today.
Nearest resistance levels: 2120, 2150, 2200
Nearest support levels: 2090, 2040, 2025, 2000, 1975, 1950, 1915, 1900, 1886
The price of the futures on the German stock index DAX30 could not break through the inclined resistance line and returned to the levels of the previous day. Currently quotes continue to be consolidated within the local triangle in the case of fixing the price below 11600, we recommend to open short positions with the potential fall to 11000, and 10600. We keep medium-term positive outlook with upside potential to 13000.
Nearest resistance levels: 12000, 12400, 12600, 13000
Nearest support levels: 11600, 11450, 11200, 11000, 10800, 10600, 10300
The price of the futures on the Japanese stock index Nikkei225 continues to gradually decline after reaching the level of 20200. At the moment the price is consolidating near the level of 20000. In order to continue the upward trend, quotations need to gain a foothold above 20200. On the other hand, the signal for the opening short position will be fixation of quotations below the mark 19800 and the inclined support line. We keep medium-term positive outlook, and recommend holding long positions.
Nearest resistance levels are: 20000, 20800, 21000, 21500
Nearest support levels: 19800, 19400, 19000, 18500, 18100, 17850, 17550, 17200


text:
Red Hat Bugzilla – Bug 189974
CVE-2006-2120 libtiff DoS
Last modified: 2007-11-30 17:07:24 EST
A bug was fixed upstream where a malformed tiff image can cause libtiff to crash
due to an OOB memory read.
Created attachment 128248 [details]
Patch extracted from upstream CVS
It's likely this issue affect RHEL2 and RHEL3 (I've not had time to check source
only affects RHEL4, tif_color.c is new in 3.6
An advisory has been issued which should help the problem
described in this bug report. This report is therefore being
closed with a resolution of ERRATA. For more information
on the solution and/or where to find the updated files,
please follow the link below. You may reopen this bug report
if the solution does not work for you.


text:
Kimono Tribal Set in Red
Sizing & Details
Look like a california gurl in this loud outfit that is bound to highlight your zest in life! Find comfort while standing out amongst the crowd in a matchy cardigan and runner shorts. Be sure to pair this with a solid tee or tank to let the prints talk.
Also available in Blue.
Made of quality chiffon.
Top: undefined PTP across / 25.5" down
Bottom: 11"-13" across / 10" rise/ 13" down
Model is 160cm, UK6.
(Click here for Sizing Guide)
Need help? Email us at email@example.com
BFree normal shipping to Singapore & Malaysia.
Need help? Email us at firstname.lastname@example.com


text:
The Pride of Jesse Hallum / Johnny Cash DVD ONLY
Actors: Johnny Cash, Ben Marley
Directors: Gary Nelson
Run Time: 105 minutes
DVD ClassiX is a high quality public domain range are produced on professional quality DVD-R discs.Item description has been taken from numerous sources as is believed to be correct. E&OE
Item is a new, unused and supplied in Cardboard Sleeve - Region:0, Will Play in any Country around the World
Artwork is for illustration only and may differ. All Trademarks Acknowledged.


text:
- Doctors
- New Jersey
- Millburn
- Optometrists
- Dr. Vince J. McGlone
You may also like
Ratings for Dr. Vince J. McGlone
Dr. McGlone has the patience of a saint! He takes all the time he needs to get the job done. I truly respect his talent and trust him explicitly. If you are looking for a thorough and knowledgeable doctor, this is the one to go to.
Friendly, knowledgeable staff. I would recommend my family and friends go to New Jersey Contact Lenses in Millburn!
This man is extremely RUDE! I saw him outside of his office. He did not recognize me as a patient and proceeded to yell at me while at a local gas station like a lunatic. When I told him I was a patient of his, he was shocked and embarrassed. He sat there in his Mercedes thinking who the heck he is. Newsflash...just because you have a Mercedes, Vince McGlone, doesn't mean you're better than anyone! Nonetheless, I never went to him again and also called the office to complain. His staff was completely apologetic and assured me that he is nasty to everyone including them. A medical degree and a Mercedes doesn't make you better than anyone!
I found the office to be courteous and Dr. McGlone to be extremely knowledgeable and helpful. Found great contact lenses and the best glasses prescription I have had in a long time.
Have seen him numerous times since corneal transplant surgery and he has been able to help me get on with my life. He and his staff have put in many hours with me and my lenses.
Excellent staff, doctors very helpful and knowledgeable. I need very accurate correction for my profession, and these doctors were able to give me exactly what I need.
The first problem I had was showing up for an appointment which they did not have written down. Luckily, they did take me, but I had to wait and was not on the schedule anywhere. After less than three months of wearing my new $400 contact lenses, one lens ripped in half, they wanted to charge me almost full price for a replacement lens. I have worn contact lenses for 30 years, never had a lens rip apart on me. I wrote and called Dr.McGlone. He never even acknowledged my phone call or letter. Was able to order my lens myself for less than half the price. Office manager not nice. I would not recommend Dr.McGlone to any friend etc. Very overpriced. Never paid $400 for contact lenses plus fitting fee costs.
WORST eye doctor ever! Not only did they get my prescription wrong THREE times, but they keep trying to charge me for the appointment coming in to get my correct prescription. They told me that they would wipe the charges clean since they were the ones who kept messing up, but NOPE, they didn't. The whole place is horrible, I was better off going to a mall eye doctor than them.
I would not recommend this doctor ! I waited for staff to assist me for over 30 min! Not only was his attitude very poor in treating me as a new patient, he was VERY rude to his staff in front of me. The staff was not friendly however with a doctor like that who can blame them. Overcharged for services with additional "fitting fee" for my contact lenses, on top of my co-payment, reason being he has to spend time with more time with me. I have never had a worse experiences with a doctor. Will not return!
Vince McGlone is rude and his office manner is unprofessional. How he manages to stay in business is beyond me. My experience was a bait and switch and when disputed he hung up the phone on me. I do not recommend his services and would avoid
Dr. Vince J. McGlone's Credentials
Facility Affiliations
Accepting New Patients
- University Of California - School Of Optometry (Grad. 1990)
Other Specialties
Areas of Expertise
Awards & Recognitions
Publications & Research
Insurance accepted by this Doctor
Find a Doctor by Specialty
Featured News
You may also like
Top Optometrists
#1 of 3
#2 of 3
#3 of 3


text:
|Thread Tools
What do you think of this?
I am all for BF in public and have done it countless times myself, but really, I think this woman is going a bit too far! Is it really necessary to clear the table and BF the baby at the same time? I don't really think it is a food saftey issue, but why do this? Sit down and feed the baby!
Blech...I made the mistake of reading the comments. I agree with the ones who say it's a bad business move, but so many of the comments are just ridiculous.
eta: As someone who has a hard time sitting still sometimes, I totally understand the multitasking: there were times when sitting down waiting for the baby to finish nursing meant I was antsy, and trying to convince the kid to hurry up and finish, but if I was up doing something while the kid nursed in a sling, I was more relaxed, and the baby could take as long as necessary.
Me: Sarah, married to: J, mommy to: C (8/10) and E (11/12)
I really couldnt care less. Let her nurse her baby. The customers, like so many people, need education in the subject of breastfeeding.
I know this thread is a bit old but I clicked it being curious what breastfeeding controversy there could possibly be in Canada lol
I kind of agree that breastfeeding shouldn't be done while handling someone else's food or implements. Breastmilk can sometimes shoot several feet, customers have the right not to want someone's bodily fluids in their food. There are diseases which can be transmitted via breastmilk, the likelihood of diseases actually being transmitted that way are probably close to zero, but the possibility is still there.
I wouldn't call the health department on something like that myself, but if someone has a complaint about it, I don't think the health department was entirely wrong to issue the warning.
Seems more like she is trying to promote her restaurant by calling the news than fighting for human rights.
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Our Mission is to help you accomplish YOUR Mission.
Organizations frequently treat symptoms of their challenges instead of addressing root causes.
Ultimately wasting time and resources and creating unnecessary frustration for their customers and employees.
Sustained organizational growth begins with TRUTH.
SOLUTIONSinclude the development of individuals, leaders & processes.
Resulting in your ability to be highly effective and to achieve unprecedented RESULTS.
Giana Consulting was founded by Chery Gegelman.
After years of leading change from the middle and the edge of organizations Chery is convinced of three simple truths. Truths that have the power to transform your organization. Truths that many leaders either don't know, or don't leverage:
1. Most of the answers organizations are seeking today are lying dormant inside of their employees, their customers and their suppliers just waiting to be discovered and unleashed.
2. Each of us is capable of making an extraordinary difference regardless of what our title is.
3. Anyone with a leadership or management title has a great responsibility to listen, to model the behavior they would like to see, and to serve those they employ.
Giana Consulting helps people and organizations lead through change to growth:
- We inspire people that see solutions for their workplaces and their communities to share their wisdom.
- We provide tools and support for people who know they can make a greater difference and are struggling to be heard.
- We help titled leaders grow their understanding, compassion and commitment to leading with character.
- We offer understanding, hope and resources that are in the midst of life-altering personal changes.
We've worked with:
- Front line employees, mid-level leaders, and executives.
- Automotive Groups, Community Colleges, Career Schools, Large Non- Profit Organizations, Government Agencies, Staffing Services, Insurance Companies, International Residential Compounds, Faith-Based Organizaitons, and other Consulting Companies both nationally and internationally.
Our Core Values:
I am convinced that once organizational health is properly understood and placed into the right contextit will surpass all other disciplines in business as the greatest opportunity for improvement and competitive advantage. Really. ~Patrick Lencioni


text:
Monday, June 9, 2014
Non-Toxic Homemade Cleaners - #HomemadeCleaners
Majority of store boughten cleaners are very toxic. Have you ever thought about making homemade cleaners before? Many cleaning products that we use to keep our homes clean are toxic to the environment and our families. You'll be pleasantly surprised to find that creating homemade natural cleaning products are fun to make, affordable and very simple to make!
Homemade Cleaners
For this review, I received a copy of Homemade Cleaners - Quick and Easy, Toxic-Free Recipes! I was very impressed with all of the recipes! This book is very informative. Did you know that companies that manufacture cleaning products are not obligated to list the ingredients in their products? That is just pain wrong!!! The only way manufacturers are required to list chemicals that are strongly linked to serious toxicity only if they account for more than 1 percent of the product's weight. It's hard to believe what they can get away with. Also, they are required to list suspected carcinogens only if they account for more than 0.1 percent of the product's weight and they can legally omit hazardous chemicals if they are part of a mixture the company claims to be a trade secret!
Even if the chemicals don't cause a problem today, they may in time cause long-term problems! So, why would anybody put their family at risk for serious health problems, by using toxic cleaners? Lets take carcinogens for example, it's directly involved in causing cancer. Carcinogens are either genotoxic or nongenotoxic. Genotoxins cause irreversible damge or mutations by binding to DNA. Nongenotoxins do not affect DNA directly but instead disrupt cellular metabolic processes and promote cancerous growth. Carcinogens do not cause cancer on their own, but they promote the cancer-causing activities of carcinogens.
The authors, Mandy O'Brien and Dionna Ford talk about other chemicals, such as endocrine disruptors, neurotoxins and many others. They also tell you about the cautionary labels and how companies do GREENWASHING. Labeling a product "natural" or "environmentally friendly: is no more than a marketing ploy! By reading a label that says "natural", what says it"s natural, there are no set rules, since the companies can label their products at their own discretion and that includes biodegradable products.
Here's an interesting fact that I didn't know about. Simple Green Concentrated All-Purpose Cleanser, is labeled as "nontoxic" and "biodegradable," and it's sold in a spray bottle. The spray nozzle implies that the purchaser may use the products without diluting it, and there are no conspicuous directions on the bottle to the contrary. However, the company's website advises users to significantly dilute the cleaner, even for heavy-duty cleaning. So, it can put you at risk and Simple Green labels the cleaner as non-toxic, but it does contain a solvent that damages the red blood cells and is an eye irritant (2-butoxyethanol), as well as a blend of alcohol ethoxylate surfactants, some of which are banned in the European Union.
The authors talk about other cleaners, including Dawn and, Comet and how toxic they are. So, they encourage us to keep our families and the environment safer with homemade cleaning products. Plus it will save you a bundle of money and you won't have to put up with the fumes.
Here's another interesting fact, that I just love! Studies have shown that cleaning surface with a vinegar mixture, followed by hydrogen peroxide, actually does a better job of cleaning viruses and bacteria than bleach!
The book goes on to tell you how to get started on making your own cleaning products and what you'll need. Most of the ingredients for making your all-natural cleaning products are likely already in your kitchen!
Here's a List of Ingredients:
- Baking Soda
- White Distilled Vinegar
- Lemon Juice
- Borax
- Castile Soap
- Hydrogen Peroxide
- Vodka
- Washing Soda
- Water
- Witch Hazel
- Essential Oils
The authors tells you what the best essential oils are, but it's more up to you, which fragrance you prefer. After talking about the essential oils, they go into what are the best carrier oils for their recipes. You will need containers, that have not already had some sort of chemical products in them. Make sure you label the bottles and write down the ingredients, so you know exactly what you made. Now, after you made your homemade cleaners, you will need some type of cloth to clean with, the book gives many great ideas what you can use as cleaning rags.
Table of Contents:
- Introduction: Simple Steps
- How Safe Are Your Cleaning Supplies?
- Getting Started
- Simple Cleaning
- Mirrors and Glass
- Cleaning The Kitchen
- Bathrooms
- Flooring and Walls
- Furniture
- Laundry Simplified
- Clean Air
- Outdoor Living
- Bugging Out
- Naturally Healthy Yards
- For Parents
- A Disposable Society
- Reduce and Reuse
- Conclusion
- EndNotes
- Acknowledgments
- About the Authors
After reading all the great information mentioned above, the book gets into all the AWESOME recipes to clean everything in your home and to think it's all natural, with no toxic chemicals! There are 150 recipes and I have already been using quite a few of them, before I started reading the book, but I can't wait to try all of them. This book is perfect for anybody who wants to live a greener lifestyle!
I would highly recommend Homemade Cleaners! This book is so full of information and very well written. Once you pick it up, you won't want to put it down!
► Learn how to make homemade cleaners, without toxic chemicals! #HomemadeCleaners #cleaning http://t.co/P40o70Fxbx pic.twitter.com/sDXgmMtBNR— Quick Tattletails (@bonmay) June 10, 2014
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Posted by Bonny Sallee at 6/09/2014 05:45:00 PM
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Dynojet - Power Vision Tune License
Power Vision Tune License
The Power Vision licensing program allows for an unlimited number of motorcycles to be added to your Power Vision to be tuned. Each additional motorcycle requires a Tune License to be added.
There are two types of ECM cables for the HD Twin Cam motors. Please be sure to check the list below to ensure you have the correct cables to connect your Power Vision to the motorcycle!
PV-1 Cable
2002-2013 HD Touring Models
2001-2010 HD Softail Models
2004-2011 HD Dyna Models
2007-2013 HD Sportster Models
2002-2017 HD V-Rod Models
PV-2 Cable
2014-2017 HD Touring Models
2011-2017 HD Softail Models
2012-2017 HD Dyna Models
2014-2017 HD Sportster Models
- Attach the Power Vision to the motorcycle you need to retrieve the ECM data from with the supplied cable.
- NOTE: This is the bike you are adding to the Power Vision, not your existing motorcycle!
- Turn the ignition on and ensure that the kill switch is in the 'Run' position (your engine is not running).
- On the Power Vision main menu, touch 'Vehicle Tools'.
- Touch 'Read ECM' (A warning will pop up, touch 'Yes' to continue).
- You will be presented a 'Success' screen that will report the name of the file we will retrieve using your computer (ie 06-JAB-YNKX99M.stk)
- Touch 'OK' on the Power Vision screen and turn your ignition off.
- Disconnect the Power Vision from your vehicle.
- Connect your Power Vision to your computer using the provided USB cable.
- The Power Vision will boot up and says "PC Link Mode Active".
- Launch the WinPV Software on your computer.
- On the menu bar, go to "Power Vision", and choose "Diagnostic Test functions > Get ECM Data from PV".
- A warning will pop up, click 'Yes' to continue.
- Highlight the STK file by left clicking on it. (In step 5, our STK file was named "06-JAB-YNKX99M.stk" however this file name will be slightly different for every motorcycle).
- Click on 'Get' and save to the default directory, C:\My Documents\Power Vision\Diagnostics.
- Repeat steps 11-14 to obtain the DiagnosticsHistory.txt from the Power Vision as well.
- Upon completion, the STK file and DiagnosticsHistory.txt can be emailed to the contact email supplied once the license is purchased and a Tune License will be generated
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Accommodations in AracatiSee All
A place in Brazil, Aracati is an interesting place to visit, given its unique culture, history and character. Aracati is located at a short trip away from Fortaleza a major city in Brazil. Take a short trip from Aracati and set some time aside to explore the Fortaleza. Dotted with places like Praia Do Futuro, Morro Branco, Praia De Iracema; it will definitely be a good idea. If you want to fly to the destination, you can choose the nearest major airport to take a flight. The nearest major airport is Pinto Martins – Fortaleza International Airport. Get in the character of the city, this city requires at least of 1 to 2 number of days of exploration.
Explore the best journey planner for your visit to Aracati and create a flawless plan in few simple steps!


text:
Mexco Energy Corporation announced the drilling of certain properties in the Permian Basin of West Texas and the acquisition of producing properties in four states.
Mexco Energy Corporation is participating as a working interest owner in a joint venture drilling four (4) vertical development wells to a depth of 11,000 feet on 160 acre spacing in the Dean, Wolfcamp, Cline and Atoka formations on 640 acres in Reagan County, Texas.
Initial per day production rates from two of these wells respectively are 128 barrels of oil and 110,000 cubic feet of natural gas and 94 barrels of oil and 179,000 cubic feet of natural gas. Mexco's working interest in this joint venture is .3% (.24% net revenue interest).
Mexco Energy Corporation
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text:
- Material : aluminium/metal composite
- H: 16.5cm; Diameter : 6.5cm
The Rotary Tealight Holder from Sweden is one of our store best sellers. Each is a magical lantern of animated fascination.Above the tealight is attached a stem and a turbine disc. The disc rotates by convection when the tealight is lit and shadows are cast from the decorations hanging from it. This design features a bride and groom and makes a lovely wedding gift.
See more Candle Holders.


text:
Sunday, January 11, 2009
The Post's series on AIG ["The Crash: What Went Wrong," front page, Dec. 29-31] noted the company's belief that the credit-default swaps that ultimately led to its collapse were sound because the quality of the insured debt ensured minimal risk even under worst-case scenarios.
The question no one appears to have asked was why anyone would be willing to pay substantial amounts to avoid a virtually nonexistent risk. The fantasy of perpetual motion is a recurrent one throughout the history of "innovative" insurance products, in which credit-default swaps may now take their rightful place.
Other reporting has detailed the tremendous profitability of AIG's Financial Products unit and the entrepreneurial-level compensation its managers enjoyed. But why would an insurance product be so staggeringly profitable? Competition to provide what is, essentially, cleverly sifted publicly available information should have pushed profit margins down, but it did not.
When an insurance product's profit margins exceed 80 percent, as AIG reported in 2005, we know one of two things: Either the product is valueless because the risk is nonexistent, or it is valueless because the insurer does not intend to, or will not be capable of, meeting its obligations. At $150 billion in taxpayer funds and counting, we now know AIG's true business model.
The fascinating three-part series by staff writers Robert O'Harrow Jr. and Brady Dennis about the people and forces contributing to the collapse of AIG was a disturbing look at the greed and arrogance of that company's executives. It also revealed the complete abdication of oversight by Securities and Exchange Commission staffers and other government officials who should have discovered this economic time bomb before it went off in their faces.
But the icing on the cake was the disclosure that the perpetrators of this disaster were given severance packages worth tens of millions of dollars after their actions led to the biggest collapse of our financial system since the Depression. Why does our government continue to allow companies to reward executive mismanagement while we taxpayers are stuck with the bill? Hopefully, the new administration will make regulatory changes to stop this.
View all comments that have been posted about this article.


text:
what the hell does Andy Moeller have to do to get fired.
Printable View
what the hell does Andy Moeller have to do to get fired.
Keep hitting RG3.
Oherrated strikes again.
Oher cant give that up to basically a sub package player, Rob Jackson is a solid rusher but c'mon
Awful job by Oher
reed still picks his times to make a play.
Our D seems to have least slowed them down A LITTLE bit. Not the gaudy average per play.
Joe is just the kind of passer who NEEDS solid blindside protection and he didn't get anywhere close to that on the strip sack. He could have stepped up, but he only needed another split second, the ball was on its way out.
Just a bad break all around on that play. It was close.
Good stop defense!!!
First blitz by Pees.


text:
Full Paper
Continuous Synthesis of Device-Grade Semiconducting Polymers in Droplet-Based Microreactors
Version of Record online: 29 NOV 2012
DOI: 10.1002/adfm.201203014
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Advanced Functional Materials
Volume 23, Issue 17, pages 2123–2129, May 6, 2013
Additional Information
How to Cite
Bannock, J. H., Krishnadasan, S. H., Nightingale, A. M., Yau, C. P., Khaw, K., Burkitt, D., Halls, J. J. M., Heeney, M. and de Mello, J. C. (2013), Continuous Synthesis of Device-Grade Semiconducting Polymers in Droplet-Based Microreactors. Adv. Funct. Mater., 23: 2123–2129. doi: 10.1002/adfm.201203014
Publication History
- Issue online: 2 MAY 2013
- Version of Record online: 29 NOV 2012
- Manuscript Received: 16 OCT 2012
Funded by
- Funded Access
- Abstract
- Article
- References
- Supporting Information
- Cited By
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.


text:
Mohammad al Jililati
|This article needs to be updated. (July 2012)
|Mohammad al Jililati
|Minister of Finance
|In office
14 April 2011 – 9 February 2013
|Prime Minister
|Adel Safar
Riyad Farid Hijab
Wael Nader al-Halqi
|Preceded by
|Mohammad Al Hussein
|Succeeded by
|Ismael Ismael
|Executive Director of the Damascus Securities Exchange
|In office
February 2009 – 14 April 2011?
|Personal details
|1945 (age 71–72)
|Political party
|Syrian Regional Branch of the Arab Socialist Ba'ath Party
|Alma mater
|University of Damascus
Mohammad al Jillati (born 1945) is a Syrian economist and financial expert, who served as the minister of finance from April 2011 to 9 February 2013.[1][2]
Early life and education[edit]
Jillati was born in Damascus in 1945. He earned a bachelor's degree in economics from the Damascus University in 1967, and a PhD in economics and finance from the former Soviet Union in 1975.
Jillati was a professor at the faculty of economics of Damascus University beginning in 1975 and chairman of the accounting department where for ten years, he participated in several committees of government economic reform plans in the public sector, in addition to the supervision of many doctoral dissertations.
He served as chairman of the society of chartered accountants in Syria for four years and vice chairman of the board of commissioners of the securities commission and the Syrian financial markets from 2005 to 2009. He was acting executive director of the Damascus Securities Exchange from the establishment of the market in February 2009 to 2011.[3]
In April 2011, he was appointed minister of finance in the cabinet of Adel Safar. His term ended on 9 February 2013.[2]
Personal life[edit]
Al-Jillati is married and has 5 children.
- ^ Syria: President Bashar al-Assad forms new government, 'BBC News, 14 April 2011
- ^ a b "Syrian president reshuffles economic Cabinet posts". Al Jazeera. AP. 9 February 2013. Retrieved 9 February 2013.
- ^ Landis, Joshua (17 April 2011). "Syria's New Government". Eurasia Review. Retrieved 10 March 2013.
|Political offices
|Preceded by
Mohammed Al Hussein
|Finance Minister of Syria
|Succeeded by
Ismael Ismael


text:
Sergius I of Amalfi
From Wikipedia, the free encyclopedia
Sergius I (died 966) was the second Duke of Amalfi and first of the Musco Comite family.
In 958, Sergius, a citizen of the city of Amalfi, assassinated the first duke, Mastalus II and usurped the throne. In order to establish a ducal dynasty as in Naples and Gaeta, he immediately associated his son Manso I with him in his office. When he died, Manso's succession was smooth.
Sergius had other sons named John, Adhemar, and Leo, as well as a son named Adelfer, who later also usurped rule in Amalfi.
External links[edit]
|Preceded by
Mastalus II
|Duke of Amalfi
|Succeeded by
Manso I
|This biography of an Italian noble is a stub. You can help Wikipedia by expanding it.


text:
Today, I flew into New Zealand to surprise my girlfriend on her trip. In the New Zealand Airport I received a text message saying she wanted to break up with me. I live in Michigan and just spent $1,500 for this romantic surprise. FML
By uthinkucandraw - / Friday 27 February 2009 21:19 / United States


text:
Digital Pulse Photographer
Kayla BurksModel Female Sacramento, California, US
My MM URL: http://www.modelmayhem.com/kaylaoolala
Mayhem # 2775078
About MeHello! My name is Kayla Burks. I had a shoot with a photographer and i really enjoyed it so i thought, why not try to go a little further with this? I am really fun to work with and i have a unique style. I would like to do more risque/pin up/burlesque - type of shoots. My hair is always changing due to the fact that i am a cosmetologist. I have the back of my upper thighs tattd, my left elbow, left upper arm, left inner forearm, and script writting accross the top of my back levering onto both sides of my shoulders...getting more is in the plans! I am twenty years old, i live in SACRAMENTO CA and would LOVE to get more pictures taken! [= I would also love to do hair and make up for shoots too! Trade pictures for time to help build your portfolio as well as mine.
Have you worked with Kayla Burks? Add Credits for Kayla Burks! >>
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text:
VideoHive Water Ripple Effect 3301947
After Effects Project \ Openers \ Water
After Effects Project - Water Ripple Effect 3301947 by tete-template @ VideoHive
After Effects Project \ Openers \ Water
After Effects Version: CS4, CS5, CS5.5; File Size: 25mb; Requires Plugins: No; Resolution: 1920x1080.
After Effects CS4 or above template. Include free textures (for the background – sand texture; for the title background – wall texture; clouds texture; and some lens flare textures) feel free to use them in your future projects just do not redistribute . Project have 8 scenes 3 footage containers 2 logo or text containers. You can use this template to promote a product or use it as presentation of your summer trip, even for wedding events too. Music from the preview you can find here: http://audiojungle.net/item/water-fall/3076287?sso by adigold
- Video tutorial is included with the download.
- Free textures are included.
- Change background images of the sand and title background with you own.
- No 3th party plugins are used!
Keywords: beach, effect, holiday, light, realistic, ripple, sand, wall, water, wave.


text:
PEEP-TOE SANDALSBlack
Delivery Methods
- Standard £5
- Next Day £7
- Same Day £15
- Collect In Store Free
We also offer Free returns on all UK orders.
For next working day delivery please order before 3:00pm
For same day delivery within London please order before 1:00pm.
All orders will be delivered by courier and will need to be signed for.
Sleek, sopshicated and undeniably modern, the black leather Mayton heels are the perfect evening pair. The cut-away sides and open toe will lend outfits a graphic twist and the slim stiletto heel secures their evening status. Wear them with wide-leg trousers or a bodycon dress after dark.
- Open toe
- Cut-away side details
- Slim stiletto heel
To ensure every REISS garment is the perfect fit for you, please refer to our size guide and check our measurements.
Composition - 100% Calf Leather
Lining Composition - 100% Kid Leather
Washcare - Dry wipe clean, Wipe clean


text:
Assessment of Eloquent Function in Brain Tumor Patients
This study is currently recruiting participants.
Verified May 2016 by Michele Aizenberg Ansari, MD, University of Nebraska
University of Nebraska
Information provided by (Responsible Party):
Michele Aizenberg Ansari, MD, University of Nebraska
ClinicalTrials.gov Identifier:
First received: February 8, 2012
Last updated: May 26, 2016
Last verified: May 2016
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is currently recruiting participants.
|Estimated Study Completion Date:
|December 2018
|Estimated Primary Completion Date:
|February 2018 (Final data collection date for primary outcome measure)


text:
Mr Color Thinner 110ml T102
GSI Creos
$ 5.25
Sorry, this item is out of stock
Mr Color Thinner 110ml T102
Mr. Thinner is a necessary to thin paints and wash brushes. Mr. Thinner is a high quality material. It is simple to use and mix with Mr. Color. Tested and certified radiologically inert.


text:
Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
i have lived in california and have not left california for 20 years i have had a valid california drivers license for 30 years have renewed my license several times. I renewed this time on-line when i was notified arizona has blocked my renewal. I have never been in touble with law criminally or civally have always paid my tickets (the very few i have gotten in a timely manner) I have no records that go back 20 years
Check with the Arizona MVD and get a copy of the ticket. You have to fight it to get it removed. Call 800-251-5866
The response given is not intended to create, nor does it create an ongoing duty to respond to questions. The response does not form an attorney-client relationship, nor is it intended to be anything other than the educated opinion of the author. It should not be relied upon as legal advice. The response given is based upon the limited facts provided by the person asking the question. To the extent additional or different facts exist, the response might possibly change. Attorney is licensed to practice law only in the State of California. Responses are based solely on California law unless stated otherwise.Ask a similar question
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text:
Predicting drug side-effect profiles: a chemical fragment-based approach
Drug side-effects, or adverse drug reactions, have become a major public health concern. It is one of the main causes of failure in the process of drug development, and of drug withdrawal once they have reached the market. Therefore,
In the present work, we propose a new method to predict potential side-effects of drug candidate molecules based on their chemical structures, applicable on large molecular databanks. A unique feature of the proposed method is its ability to extract correlated sets of chemical substructures (or chemical fragments) and side-effects. This is made possible using sparse canonical correlation analysis (SCCA). In the results, we show the usefulness of the proposed method by predicting 1385 side-effects in the SIDER database from the chemical structures of 888 approved drugs. These predictions are performed with simultaneous extraction of correlated ensembles formed by a set of chemical substructures shared by drugs that are likely to have a set of side-effects. We also conduct a comprehensive side-effect prediction for many uncharacterized drug molecules stored in DrugBank, and were able to confirm interesting predictions using independent source of information.
The proposed method is expected to be useful in various stages of the drug development process.
Drug side-effects, or adverse drug reactions, have become a major public health concern. It is one of the main causes of failure in the process of drug development, and of drug withdrawal once they have reached the market. As an illustration of the extent of this problem, serious drug side-effects are estimated to be the fourth largest cause of death in the United States, resulting in 100,000 deaths per year
From the viewpoint of systems biology, drugs can be regarded as molecules that induce perturbations to biological systems consisting of various molecular interactions such as protein-protein interactions, metabolic pathways and signal transduction pathways, leading to the observed side-effects
Although preclinical
The principle of pathway-based approaches is to relate drug side-effects to perturbed biological pathways or sub-pathways because these pathways involve proteins targeted by the drug. In a pioneer work to illustrate this concept, it has been shown that drugs with similar side-effects tend to share similar profiles of protein targets
The principle of chemical structure-based approaches is to relate drug side-effects to their chemical structures. Scheiber et al developed a method that identifies chemical substructures associated to side-effects
In the present work, we develop a new method to predict potential side-effect profiles of drug candidate molecules based on their chemical structures, which is applicable on large molecular databanks. A unique feature of the proposed method is its ability to extract correlated sets of chemical substructures (or chemical fragments) and side-effects. This is made possible using sparse canonical correlation analysis (SCCA). To our knowledge, no other computational method has been reported for both predicting drug side-effects and associating these side-effects with the presence of identified chemical substructures. In the results section, we show the usefulness of the proposed method on the prediction of 1385 side-effects in the SIDER database from the chemical structures of 888 approved drugs. These predictions are performed with simultaneous extraction of correlated ensembles formed by a set of chemical substructures shared by drugs that are likely to have a set of side-effects. We also conduct a comprehensive side-effect prediction for many uncharacterized drug molecules stored in DrugBank, and were able to confirm interesting predictions using independent source of information.
Data representation
Side-effect keywords were obtained from the SIDER database which contains information about marketed medicines and their recorded adverse drug reactions
Figure 1
Characteristics of side-effect data
Characteristics of side-effect data. The left panel shows the index-plot of the number of associated drugs for each side-effect, and the right panel shows the histogram of the number of associated drugs for each side-effect.
To encode the drug chemical structure, we used a fingerprint corresponding to the 881 chemical substructures defined in the PubChem database
The other drug information (e.g., ATC code, drug category, protein target) was obtained from DrugBank
Performance evaluation
We applied nearest neighbor (NN), support vector machine (SVM), ordinary canonical correlation analysis (OCCA), and sparse canonical correlation analysis (SCCA) to predict drug side-effect profiles. We also applied random assignment procedure (Random) as a baseline method. For the details of the algorithm of each method, see the Methods section. First we tested five methods: Random, NN, SVM, OCCA and SCCA for their abilities to predict known side-effects profiles by the following 5-fold cross-validation. Drugs in the side-effect data were split into 5 subsets of roughly equal size, each subset was then taken in turn as a test set, and we performed the training on the remaining 4 sets. For accurate comparison, we kept the same experimental conditions, where the same training drugs and test drugs are used across the different methods in each cross-validation fold. We evaluated the performance of each method by the ROC (receiver operating characteristic) curve
Figure 2
ROC curves in the 5-fold cross-validation
ROC curves in the 5-fold cross-validation. Comparison of the performance between nearest neighbor (NN), support vector machine (SVM), ordinary canonical correlation analysis (OCCA) and sparse canonical correlation analysis (SCCA).
Figure 3
Boxplot of the prediction accuracy of predicted side-effects for each drug
Boxplot of the prediction accuracy of predicted side-effects for each drug. Prediction accuract of top 10 ranked predictions (top panels) and top 100 ranked predictions (bottom panels). Comparison of the performance between nearest neighbor (NN), support vector machine (SVM), ordinary canonical correlation analysis (OCCA) and sparse canonical correlation analysis (SCCA).
We also examined the prediction accuracy for individual side-effects. We draw the ROC curve for each side-effect, and computed the AUC score for each side-effect. Figure
Figure 4
Boxplot of the AUC (under the ROC curve) scores for individual side-effects
Boxplot of the AUC (under the ROC curve) scores for individual side-effects. Comparison of the performance between nearest neighbor (NN), support vector machine (SVM), ordinary canonical correlation analysis (OCCA) and sparse canonical correlation analysis (SCCA).
We are also interested in biological interpretability of the outputs of the proposed method to understand the relationship between chemical substructures and side-effects. We focused on OCCA and SCCA, because they are the only methods which can correlate two heterogeneous high-dimentional data sets. We examined the weight vectors for drug chemical substructures and drug side-effects in OCCA and SCCA. Figure
Figure 5
Index-plot of weight vectors for drug substructures and side-effects in OCCA
Index-plot of weight vectors for drug substructures and side-effects in OCCA. Index-plot of weight vectors for drug substructures (left) and side-effects (right) extracted by ordinary canonical correlation analysis (OCCA).
Figure 6
Index-plot of weight vectors for drug substructures and side-effects in SCCA
Index-plot of weight vectors for drug substructures and side-effects in SCCA. Index-plot of weight vectors for drug substructures (left) and side-effects (right) extracted by sparse canonical correlation analysis (SCCA).
Finally, we investigated the computational cost for each method. All methods were implemented using R software on a Linux with 2.16 GHz Intel Core 2 Duo processor and 8 GB RAM. The total execution times of the cross-validation experiment for NN, SVM, OCCA, and SCCA are 2, 5885, 58, and 76 seconds, respectively. Figure
Figure 7
Computational cost
Computational cost. Total execution time of the cross-validation experiment for the four methods (log10 scale).
Extracted sets of drug substructures and side-effects
From biological viewpoints, we examined the extracted sets of drug substructures and drug side-effects in each canonical component extracted using SCCA. Note that the other methods (NN, SVM, and OCCA) do not enable us to interpret the biological features. Each component consists of only a small number of substructures and a small number of side-effects that are correlated with each other according to SCCA. For each component, two lists of drugs are provided: one containing drugs with a high score for the associated substructures, and one containing drugs with a high score for the associated side-effects. We examined the results when we used the best parameters which provided the highest AUC for all side-effect terms. Because of space limitation, the results for a few canonical components will be discussed in this paper. The results for all canonical components can be obtained from Additional file
Additional file 1
Extracted features by the proposed method. All the results for drug chemical substructures and drug side-effects extracted by Sparse CCA are summarized in this file.
Click here for file
A canonical correlation coefficient is computed to evaluate the importance of each component. The p-values for the canonical correlation coefficients of top 20 components considered in the paper are almost zeros. The components with high canonical correlation tend to contain rare substructures present only in very few drugs, which are associated to rare side-effects mainly observed for these drugs. These components contain quite specific substructure/side-effect canonical correlations whose interpretation is straightforward. For example, component 6 associates the presence of a boron atom, only found in the bortezomid molecule in the SIDER database, to a short list of neurological side-effects observed only for this drug. Similarly, component 20 essentially clusters a substructure defined by a carbon atom bearing both a bromide atom and a nitrogen atom. This substructure is found only in the bromocriptine molecule of the SIDER database, with two side-effects observed only for this drug (namely, pregnancy induced hypertension and toxemia of pregnancy).
In the general case of components containing more frequent substructures, drugs that contain these substructures tend to present side-effects associated to this component, but this correspondence is not strict. Reciprocally, most drugs that have high scores for the side-effects contain the chemical substructures of this component, but not all. Analysis of component 18 can illustrate these points. Component 18 has a high canonical correlation of 0.739 (the p-value is almost zero). It contains two substructures, the major one being the presence of "four or more saturated or aromatic nitrogen-containing rings of size 5", associated to four side-effects. This substructure is present in five drugs of the SIDER database: verteporfin, porfimer, goserelin, buserelin, and leuprolide. Verteporfin and porfimer contain a porphyrin group displaying four nitrogen-containing rings of size 5, as shown in Figure
Figure 8
Nitrogen-containing rings of size 5
Nitrogen-containing rings of size 5. (A) Porphyrin group, (B) Proline residue, (C) Histidine residue, (D) Tryptophane residue.
Overall, four or more nitrogen-containing rings of size 5 are indeed present in their structures. Note however that these rings are different from those of the porphyrin group. Although goserelin, buserelin and leuprolide on the one hand, and verteporfin and porfimer on the other hand, belong to totally unrelated families of molecules, they share common substructures, at least according to their definition in the present study. All drugs from these two families, but verteporfirin, have high scores for side-effects of this component. This result indicates that side-effects of a drug is usually associated to the presence of given substructures, although it may be modulated by the overall molecular structure, as in the case of verteporfirin. This property is also well known in the context of drug structure-activity relationship, which usually depends on given molecular scaffolds, but which is modulated by the presence of additional chemical groups.
Reciprocally, all drugs that have high scores for side-effects of component 18 contain the chemical substructures of this component, but risperidone, as shown in Figure
Figure 9
Chemical structure of risperidone
Chemical structure of risperidone. Two dimensional graph structure of risperidone.
However, in some cases, we were able to relate such unexpected results to the targets of these drugs, as illustrated by component 13. This component has a canonical correlation of 0.716 (the p-value is almost zero), and contains substructures that are essentially present in proton pump inhibitors used as anti-ulcer agents like omeprazole. It is also present in a small number of drugs from other families like pramipexole (an antiparkinson agent) or riluzone (a neuroprotective agent). As expected, these anti-ulcer agents are found in the high scoring drugs for side-effects in component 13, together with pramipexole and riluzone, although with lower scores. As for component 18, other drugs that do not contain the high scoring substructures of component 13 are however found among high scoring drugs for side-effects in this component. This is the case of ropinirole. Interestingly, ropinirole is an antiparkinson agent that targets the same protein as pramipexole, namely dopamine receptor.
This result suggests that drugs sharing some protein targets may also share some side-effects. It is also consistent with the idea that the global biological effect of a molecule (both beneficial effects and adverse side-effects) is related to its overall profile of protein targets. Taken together, our results indicate that the side-effects of a drug are modulated both by its substructures and by its targets. Note that these two factors are connected since similar molecules tend to share similar protein targets, but this property was not exploited in the present study.
Comprehensive side-effect prediction for uncharacterized drugs
We then evaluated the interest of the proposed method for prediction of side-effects for uncharacterized drugs. We predicted potential side-effects for drugs in DrugBank for which side-effect information was not available in the SIDER database. We focused on 2883 drugs which are labeled as "small molecules" in DrugBank. We first make general comments on the results and then present more details for a few well-known specific examples. All the prediction results can be obtained from Additional file
Additional file 2
Predicted side-effects for unchatecterized drugs in DrugBank. All the results for uncharacterized drugs in DrugBank are summarized in this file, where the 1st column is Drug ID, the 2nd column is Pubchem compound ID, the 3rd column is the predicted side-effect, and the 4th column is prediction score.
Click here for file
Very frequent side-effects, such as "headache" or "nausea" are found in SIDER, and they occur with many drugs. These side-effects are not specific, and they do not appear for a well defined drug category. They are the most frequently predicted side-effects, but they hardly appear with the highest prediction scores for a given drug, which is consistent with the fact that they are common reactions. However, we also find more specific side-effects which are related to special types of drugs. For example, steroids may lead to "striae", or "linear atrophy", which results in local dermal structure atrophy and skin depigmentation
We also checked famous examples of withdrawn drugs. Rimonabant (DB06155 in DrugBank) is an anti-obesity agent. It was rejected for approval in the United States, but it was accepted in Europe in 2006. In october 2008, the European Medicines Agency recommended suspension of its marketing authorization because of serious psychic side-effects, mainly severe depression. Indeed, this drug is active in the central nervous system, which may trigger very broad and complex psychic mechanisms. Consistent with this, in our prediction profile, the "borderline personality disorder" and "posttraumatic stress disorder" keywords are found in the ten top ranking keywords for this drug. In other words, our method would have foreseen potential psychoactivity for rimonabant. Furthermore, the method provides a potential rationale for appearance of these psychotic effets. Rimonabant contains the substructure shown in Figure
Figure 10
Rimonabant substructure selected by the proposed method to be a clue of psychoacticity
Rimonabant substructure selected by the proposed method to be a clue of psychoacticity. The substructure of Rimonabant is selected to be a clue of psychoacticity.
In this paper we showed the usefulness of the proposed SCCA method in the analysis of chemical structures and side-effects, but there are several limitations on SCCA. One main difficulty of using SCCA is to choose appropriate sparsity parameters and appropriate number of components. High sparsity promoting parameters would lead to an over-sparse model in all the cases, which might be misleading in the interpretation if the degree of sparsity was not tuned carefully. The optimal parameters value depends highly on the definition of the objective function to be investigated in the cross validation. We evaluated both global prediction accuracy, involving all possible drug-sideeffect associations, and local accuracy considering each sideeffect keyword independantly. Those two evaluation procedures did not lead to the same optimal parameter values (it varies between 0 and 1). The definition of an appropriate objective function in the cross-validation is an important issue. There remains much room to develop a more appropriate way to choose the parameters, depending on the goal of the analysis. When the goal is the global accuracy (accuracy for all side-effects for each drug), the sparsity parameter producing the best results tends to be very low, which produces canonical components associated with very few substructures and side-effects as shown in the results section. On the other hand, the goal is the local accuracy (accuracy for individual side-effects), the sparsity parameter producing the best results tends to be relatively high, which produces canonical components associated with a larger number of substructures and side-effects. The extracted features based on SCCA is also influenced by the procedure of data normalization. In this study we normalized two data sets by centering and scaling with unit variance. In our experience, when the scaling is performed on data sets, SCCA tends to extract less frequent features (both side-effects and chemical substructures). On the other hand, when the scaling is not performed on data sets, SCCA tends to extract more frequent features (both side-effects and chemical substructures). Therefore, an appropriate data normalization procedure is supposed to be performed taking into account the objective in practical applications. For example, if the user wants to extract rare features, the scaling is encouraged, but otherwise, the scaling is not necessary.
Another possible statistical method with high interpretability would be a decision tree learner or a rule learner. However, these methods can be applied to only one response variable (one side-effect term in this study). For example, if the decision tree method
The proposed methods depend highly on the pre-definition of chemical substructures, and the terminology of side-effect keywords. Future development could evaluate the performance of using other fingerprints. For example, commercial softwares such as Daylight or Dragon provide drug structure descriptors, and commercial databases such as PharmaPendium provide other side-effect terms. Another interesting research direction is to extract informative chemical sub-structures directly from the raw structured data (e.g., 2D or 3D graph structures for drugs) without using pre-defined feature representation. Recently, a data mining technique has been proposed in order to extract complex graph features, which do not require the pre-definition of feature vectors representing each molecule
In this paper we proposed a novel method to predict potential side-effect profiles of drug candidate molecules based on their chemical structures using sparse canonical correlation analysis (SCCA). The method is computationally efficient and is applicable on large datasets. The originality of the proposed method lies in the integration of chemical space and pharmacological space in a unified framework, in the extraction of correlated sets of chemical substructures and side-effects, and in the prediction of a large number of potential side-effects at a time. To our knowledge, no previous work gathers all these features.
The proposed method is expected to be useful in various ways and at various stages of the drug development process. At early stages, among several active drug candidates, the method could help to choose the molecules that should further continue the process and those that should be dropped. It could also help to find new indications for known drugs, a process named drug repurposing. Indeed, side-effects of drugs used in a given pathology can be viewed as a beneficial effect in another pathology. Sildenafil is a famous example of such drug repositioning. The method could help to identify chemical substructures of known drugs that might participate in the appearance of a given side-effect. These substructures could be used as building blocks in fragment-based drug discovery approaches
We propose five possible methods to predict drug side-effect profiles from the chemical structures.
Random assignment (Random)
To evaluate how difficult the problem considered in this paper is, we apply a random assignment procedure, that is, we use the 0/1 ratio to assign a binary label to each test drug randomly. For example, if the ratio in given training data is 90%, we can assign zero for 90% of examples in test; otherwise 1. This method is used as a baseline method in this study.
Nearest neighbor (NN)
The most straightforward approach is to apply the nearest neighbor (NN), which predicts a given drug x to have the same side-effects as those of the drug (in a training set) whose chemical substructure profile is the most similar. For each query drug, we look for k nearest neighbors, and if
Support vector machine (SVM)
A more sophisticated approach would be to apply a supervised binary classification method for predicting whether a given drug x has a side-effect or not, and repeat this process for all
Ordinary canonical correlation analysis (OCCA)
Suppose that we have a set of
Consider two linear combinations for chemical substructures and side-effects as
Let × denote the
In other high-dimensional problems, it is known that good results can be obtained by treating the covariance matrix as a diagonal matrix
Sparse canonical correlation analysis (SCCA)
In the OCCA, the weight vectors
To impose the sparsity on
where || · ||1 is
The optimization problem in SCCA can be regarded as the problem of penalized matrix decomposition of the matrix
The optimisation problem formulated in (4) can be used for finding one canonical component. To extract multiple canonical components, we use a deflation manipulation iteratively as follows:
Finally, we obtain
If the extracted sets of chemical substructures and side-effects are biologically meaningful, potential side-effects for a new drug candidate molecule should be predicted by looking for the extracted chemical substructures in its chemical structure. Suppose that we are given the chemical structure profile x of a new drug candidate molecule, and we want to predict its potential side-effect profile y based on the extracted sets of chemical substructures and side-effects encoded in
The x and y are assumed to have their canonical components u =
We also consider another prediction score. Based on the weighted sum of canonical components, we propose the following prediction score for a given molecule x:
where Λ is the diagonal matrix whose elements are canonical correlation coefficients. Note that
In our experience, eq. (7) works similarly as or slightly better than eq. (6), so we use eq. (7) as the prediction score in the result section.
Authors' contributions
EP - has made substantial contributions to the preparation of the datasets and implementation of the methods, and has also been responsible for drafting the manuscript. VS - has made substantial contributions to the biological interpretations, and has been responsible for drafting some parts of the manuscript. YY - has directed the work, and has been responsible for drafting some parts of the manuscript. All authors read and approved the final manuscript.
Project name: Side-effect analysis project; Project home page:
We thank Jean-Philippe Vert for useful discussions.
When good drugs go bad
Pharmacogenetics in oncology: a promising field
Platinum neurotoxicity pharmacogenetics
Predicting drug side-effects by chemical systems biology
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis
Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development
Computational predictive programs (expert systems) in toxicology
Drug target identification using side-effect similarity
Side Effect Prediction using Cooperative Pathways
Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors
Mapping adverse drug reactions in chemical space
Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework
A side effect resource to capture phenotypic effects of drugs
PubChem as a Source of Polypharmacology
DrugBank: a comprehensive resource for in silico drug discovery and exploration
Use of receiver operating characteristic (ROC) analysis to evaluate sequence matching
Perilymphatic atrophy of skin. An adverse side effect of intralesional steroid injections
New insights into transient global amnesia: recent imaging and clinical findings
Ventricular arrhythmias in aortic valve disease: Analysis of 102 patients
Computational verb decision trees
Fragment generation and support vector machines for inducing SARs
The levelwise version space algorithm and its application to molecular fragment finding
Frequent Subgraph Discovery
Fast and Complete Mining Method for Frequent Graph Patterns
Frequent free tree discovery in graph data
gSpan: Graph-Based Substructure Pattern Mining
Partial Least Squares Regression for Graph Mining
From fragment screening to potent binders: strategies for fragment-to-lead evolution
Support vector machine classification and validation of cancer tissue samples using microarray expression data
Relations between two sets of variates
Comparison of discrimination methods for the classification of tumors using gene expression data
Class prediction by nearest shrunken centroids, with applications to DNA microarrays
A penalized matrix decomposition, with applications to sparse principal components and canonical correlation analysis


text:
Not just an art experience, inStill integrates art, literacy, and humanities.
Immersive, discovery and activity-based, inStill Gallery Experiences employ a workshop model to transform our galleries into a classroom for grades 4–12. Students do most of the talking during inStill and our professional team of gallery teachers facilitates hands-on, standards-aligned lessons in the gallery setting. inStill Gallery Experiences are FREE to all schools.
Students will:
- Work in small groups of 5–7 students per CSM gallery teacher
- Make observations and demonstrate original thinking
- Participate in group discussions
- Build good questions to explore work on view
- "Write to learn" in various exercises
- Create and justify their own interpretations
- Participate in hands-on activities
- Build 21st century skills
Enduring Understanding
Art Language: Artists' work has unique characteristics grounded in the elements of art and principles of design. In order to understand an artist and their work, we need to know how to read, write, and talk about art to interpret meaning.
Lesson Choices:
- Clyfford Still's Visual Vocabulary
- Making Meaning: Questioning
Enduring Understanding
Artistic Vision and Voice: Artists make big and small choices to create, maintain, and communicate. These choices may relate to a particular artwork or a complete body of work and help articulate the vision and voice of the artist.
Lesson Choices:
- Choices Artists Make
- Transition to Abstraction
- Works on Paper (October 14, 2016-January 15, 2017)
Enduring Understanding
Art as a Reflection of Human Concerns: Looking at art in the context of history is one way to interpret works of art, and may shed light on how and why art was created. Major world events and social concerns are entry points to look at and think about art.
Lesson Choices:
- World War II and Abstract Expressionism
- Making Connections: Art and the World Around Us
Enduring Understanding
Inspiration & Influence: All artists—painters, writers, musicians and others—get their inspiration from somewhere. Looking for possible sources of inspiration can lead us to a deeper understanding of an artist's intent and creative process. Looking at art can inspire us to express our own creative ideas and thoughts.
Lesson Choices
- Connecting to Art through Poetry
Request an inStill Gallery Experience
Before your visit
- inStill Teacher Resources Packet (PDF): logistical information for your visit and background information on Clyfford Still
- Chaperone Expectations and Responsibilities (PDF): please provide a copy to each of your chaperones
Self-Guided School Visits
Self-guided school visits for grades 8–12 are available. Self-guided visits require advance reservations.
Request a Self-Guided School Visit.
For information and ideas for your self-guided school visit, download our Teacher Resources for Self-Guided Visits (PDF).
The inStill Project
inStill Gallery Experiences were informed by the inStill Project: a collaborative research and development workshop with a focused group of Denver area schools during the fall semester of 2012. Museum staff and teachers worked together over the course of the multi-visit program to create thematically integrated, standards-aligned lessons for their class's museum visits. Students participated as creators and collaborators in the museum visits—their observations, reflections, questions, and learning will shape what future students will look at, see, and do, together, at the Museum. By building our programs using collaborative work with Denver area schools, the Museum hopes to provide visiting students with deep, meaningful learning experiences that carry far beyond the walls of our institution.
Participating Schools: Aurora Academy, Ellis Elementary, Denver School of the Arts, Graland Country Day School, The Logan School for Creative Learning, The Odyssey School, and Rocky Mountain School for Expeditionary Learning.


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
I entered the intersection when the light was green, attempting to make a left turn. Intersection was very large and busy other cars in parallel lanes were also turning. Also, other cars got stuck in the intersection when the light turned, mine just happened to be the farthest out and I moved it as soon as I could.
For this type of ticket I would suggest you get an attorney to fight this. You need an attorney to create some doubt at the trial.Ask a similar question
I am not too sure you provided enough facts for us to assist you. Did the light turn red and you were blocking the intersection? Was there some reason why you could not make the turn on yellow - i.e. pedestrians, avoiding a potential accident because another driver ran a late yellow/red? It may serve you best to hire an attorney to fight this ticket for you. Most attorneys will charge between 300 and 400 for their service which when you consider that you will spend the better part of two days in court if you did this on your own is certainly worth the money.
The above answer is for general information only and is based on the information you posted. Every case is fact dependent, so to get a thorough analysis of your situation, you will need to consult face to face with an attorney licensed to practice in the jurisdiction where the incident took place. Do not conclusively rely on any information posted online when deciding what to do about your case.Ask a similar question
Might be able to show mitigation, but negative on defense. Talk to a traffic attorney.Ask a similar question
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text:
Estimating average precision when judgments are incomplete
- First Online:
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We consider the problem of evaluating retrieval systems with incomplete relevance judgments. Recently, Buckley and Voorhees showed that standard measures of retrieval performance are not robust to incomplete judgments, and they proposed a new measure, bpref, that is much more robust to incomplete judgments. Although bpref is highly correlated with average precision when the judgments are effectively complete, the value of bpref deviates from average precision and from its own value as the judgment set degrades, especially at very low levels of assessment. In this work, we propose three new evaluation measures induced AP, subcollection AP, and inferred AP that are equivalent to average precision when the relevance judgments are complete and that are statistical estimates of average precision when relevance judgments are a random subset of complete judgments. We consider natural scenarios which yield highly incomplete judgments such as random judgment sets or very shallow depth pools. We compare and contrast the robustness of the three measures proposed in this work with bpref for both of these scenarios. Through the use of TREC data, we demonstrate that these measures are more robust to incomplete relevance judgments than bpref, both in terms of how well the measures estimate average precision (as measured with complete relevance judgments) and how well they estimate themselves (as measured with complete relevance judgments). Finally, since inferred AP is the most accurate approximation to average precision and the most robust measure in the presence of incomplete judgments, we provide a detailed analysis of this measure, both in terms of its behavior in theory and its implementation in practice.
KeywordsEvaluation Incomplete judgments Robustness Average precision bpref infAP
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text:
All rings are made to order and the price shown is a guide only. Final pricing will depend on finger size and quality of stone desired.
Tip: How to check your ring sizeClick here to view questions and answers relating to 18ct White Gold Dome Ring with Pave set Diamonds, or ask your own.


text:
Elevator Goes Out Of Control, Takes Man To 31 Floors In Just 15 Seconds
A terrifying elevator incident caused a man from Chile to suffer severe injuries. José Vergara Acevedo , 31 Years Old had the scariest eleva...
A terrifying elevator incident caused a man from Chile to suffer severe injuries. José Vergara Acevedo, 31 Years Old had the scariest elevator ride of his life as the elevator he entered goes out of control and shot him up 31 flights in 15 seconds in high speed and crashed into the roof.
Read also: Teenagers Fell To Their Deaths While Having Sex
A CCTV footage posted to YouTube shows Acevedo entering the lift. At first, the elevator seemed to function normally but then the doors reopened as the lift goes into high-speed that made the man scared and desperately pressed the control buttons to make it stop. Unfortunately, the elevator cannot be stopped until it crashed the roof hurting the man and the CCTV camera got smashed into pieces. Acevedo suffered from severe head and leg injuries.


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Coffee made from beans that have been excreted by elephants has gone on sale in Abu Dhabi [2]- with a jumbo price tag of Dhs295 per serving.
The coffee is produced by feeding coffee beans to elephants, waiting a day and then collecting the beans when they are excreted in the elephant's dung. Abu Dhabi is one of the first places in the world to sell what its manufacturer jokingly calls a "crappuccino". The 'Black Ivory' brand coffee is on sale at Eastern Mangroves Hotel, Qasr Al Sarab Desert Resort and Desert Islands, which are all owned by the Thai chain Anantara. [3]
The coffee comes from the waste of elephants on a Thai animal sanctuary.
7DAYS was at Eastern Mangroves yesterday to have the first-ever cup served in the Middle East, while the manager of the hotel's Ingredients restaurant, Frederique Lehr, explained that the elephants are not fed the coffee beans if they are pregnant or don't like the taste. "They are very careful about how the elephants are treated and it will help raise money for them," she said.
Each Dhs295 serving is enough for four small cups. It is brewed in front of the customer in a 19th-Century, Austrian coffee brewer, in which paraffin heats up steam that brews the coffee before it passes through a cotton filter.
There are only 70kg of the coffee in the world, with each of the Abu Dhabi hotels getting just 1kg each.
Black Ivory's [4] owner and founder, Blake Dinkin, says that the coffee beans take on their own unique fruity flavour as they sit in the elephant's stomach, surrounded by bananas and sugar cane.
It also creates work for the elephant handlers and their wives, who search the sanctuary each morning for fresh dung, break it open with a stick and collect the undigested coffee beans with their hands.
Dinkin says that the elephant's stomach acids break down an outer protein layer on the coffee bean, which gives it smoothness and none of the bitterness of regular coffee. Eastern Mangrove's coffee expert, Jeffrey Galang, says that people should not expect a strong espresso flavour.
"It comes out of the elephant with a much lighter flavour than that, it is a unique taste," he said.
Do you think the elephant dung coffee is a good idea or will you be sticking to a more traditional brew? Share your comments with us below!
[1] http://www.syndigate.info
[2] http://www.albawaba.com/editorchoice/abu-dhabi-sea-455341
[3] http://www.anantara.com/
[4] http://www.blackivorycoffee.com/
[5] http://www.7days.ae


text:
iPhone 5 rumors: iPad 3 and iPhone 5 release date in May and June, iTV scheduled for 2013?
February 6, 2012 at 2:53 pm
Recent Apple rumor claim that the iPhone 5 could be released at the Worldwide Developer's Conference (WWDC) to be held this year in June.
Daiwa Securities, an Asian financial services firm, Japan's second largest securities brokerage, provided a screenshot of the leaked calendar from San Francisco's Moscone Center, hinting that the event could take place between June 10 and June 15.
In addition, the blog MacOtakara announces that the iPad 3 will be unveiled in March during a presentation organized by Apple.
As for the iTV, DigiTimes reports that Apple is unlikely to release the rumored Apple-branded TV in 2012.
Citing "sources in Apple's supply chain," the website wrote Friday that Sharp, the company rumored to provide display panels for the iTV, isn't ready to ship the IZGO (indium gallium zinc oxide) display panels that Apple plans to use for its device.
This means that the release date of the iTV could be pushed to the second half of the year.
The introduction of the iTV is seen by many as a major leap for Apple. The device is rumored to feature apps and voice controls powered by Siri.


text:
Why is a sunscreen lotion important ?
The skin, unlike any other sensory organ of the body, is forever exposed to the sun, pollution, rain and other weather conditions that can prove to be harmful for it. The skin acts like the perfect shield from weather changes, infections, allergies but itself is prone to falling prey to the harmful effects of the UV rays of the sun. Without a proper skin regime, the skin eventually loses its shine and attraction further inviting damage from the UVA and UVB rays of the sun. So as to protect itself from damage, the skin produces Melanin. This Melanin causes the darkening of the skin which, in layman language, is known as sun tan. Sun tan is of various kinds. Adverse effects of a sun tan can be permanent darkness, pigmentation, sun burn and scars. In worst cases, the skin is exposed to risk of skin cancer.
How to Lilac Extracts counter the effect of the sun ?
A gorgeous flower, hailed for its tantalizing fragrance, Lilac flower extracts prove to be excellent skin soothing agents. Easily penetrable Lilac extracts seep down the layers of the skin and unleash their anti-microbial action on the bacteria and infections that may result in allergies and acne. The Lilac plant's leaves contain stem cells. These stem cells act as skin cells thereby promoting the process of skin rejuvenation and regeneration. Sun tans, Sun burns and pigmentation instantly disappear with regular use of Lilac Extracts on the skin as the skin breathes properly with pores unclogged and skin perfectly protected, making it beautiful day after day.
How do Lavender Extracts prove to be effective ?
Over exposure to the sun results in damaging of the free radicals in the skin. Lavender Extracts are known to act as an apt skin protector. Lavender Extracts facilitate the regulation of sebum and oil production in the skin and also help in removal of sun tan by it's skin whitening effect and retarding the production of Melanin. Lavender Extracts are beneficial for all kinds of skin- dry, normal of combination and aid in clearing acne, dark spots, blemishes and soothing of sun burns. Allergies are drastically reduced and skin breathes healthy and flawless. Lavender Extracts' anti bacterial property and damage-reversal behavior makes it an ideal ingredient."
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text:
If youre looking to getawayfromitall then the Riu Palace Jandia is a perfect choice. Enjoying a wonderful beachfront location and surrounded by spacious tropical gardens this wellestablished hotel offers a peaceful and tranquil setting. Furnished to a excellent standard the Riu Palace Jandia boasts a good list of facilities along with occasional live music or shows during the evening. For sun lovers theres a superb sunbathing terrace and swimming pool or you can opt to take the short walk to the beach where youll find plenty in the way of attractions. Standing close to the village of Morro Jable this hotel is ideally placed for exploring the local shops bars and restaurants all can be found within easy walking distance.
Swimming pool heated during the winter
FREE sunbeds and parasols
Inernet access
FREE WiFi
Gift shop
Meals and Drinks:
Restaurant serving buffet breakfast and table waiter servicebuffet dinner
Show cooking
Formal dress code applies for dinner: men are required to wear long trousers
Theme buffet twice a week
Theme restaurant
Snack bar
Lounge bar
Table tennis
Health and beauty Wellness centre: physiotherapy Sauna massage beauty salon and more
Regular live music or shows
For Children:
Section of the main swimming pool
Hotel room for up to 3 adults consists of
Twin beds
Integrated lounge with 2 steps between levels with sofa bed
Bath and wc
Satellite TV
Safety deposit box
Balcony or terrace
Key Facts:
On the beach
Main resort area: 400 metres; Morro Jable 600 metres
201 rooms
Child age: 212 years
Telephone no: 00 34 928 54 03 70
Official rating: 4 Star
Note: :Some facilities and activities may incur a local charge
Riu Palace Jandia Hotel
Playa de Jandia
Jandia 35625


text: To get from Bergamo to San Cataldo by train you can catch one of the 5 trains that everyday travel between these two cities. The first train to San Cataldo leaves from Bergamo at 07:02 and the last train departs at 19:02. If you choose a local train the trip lasts on average 00:33 hours. For your trip from Bergamo to San Cataldo by train you can choose to leave from one of Bergamo main stations: Bergamo On Wanderio you can compare all schedules, fares and railway companies to San Cataldo and book the best itinerary starting from Bergamo.