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Changing Landscape of Leadership in Canada: Taking Stock
- Sheryl Chase
- 2 years ago
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1 Changing Landscape of Leadership in Canada: Taking Stock Bill Tholl President and CEO HealthcareCAN & Founding Executive Director Canadian Health Leadership Network
2 LEADS Booster shot : Then and Now? On the leadership front: COF and the HCIWG; HCC report. On the leadership policy front: Benchmarking study; Canadian Health Action Plan. On the research front: PHSI (1); PHSI (II) On the CHLNet front: New Strategic Plan & New ED; On the Leadership support front: LEADS Collaborative; LEADS 3.0 more to come from Dr. LEADS! AND merger to create HealthcareCAN
3 BRINGING LEADS TO LIFE from a gleam in the eye to reality! Facilitated Session Health PEI Shauna Fenwick and Bill Tholl leadersforlife consultants December 1, 2010
4 Strong leadership(is) an absolute necessity if meaningful transformation of our health system is to occur it is the foundation for other key enablers. Health Council of Canada, 2013 National Leadership Front: Then and now Federal gov t opts out (Dec. 12). CoF steps in (Jan 13). Creates HCIWG! Leading in Alice s world...
5 We need to move from innovation by accident to innovation by design Premier Ghiz (July 2012)
6 On the Leadership Research front in search of a better understanding of the importance of leadership to system redesign PHSI (I) and (II)
7 Timeline Where to Better from here? Leadership, Better Health Knowledge Mobilization & Next Steps Final Report September, 2014 National Deliberative Dialogue, March 2014 Cross-Case Analysis, Fall March 2014 Complete Cycle 3 Fall 2013 Cycles 1 & 2 of PAR Case selection, method, 2010 Initiation of project, 2009
8 Churn creates fragmentation of effort Someone gets excited about something and then they get fired or they move on and then the next new shiny thing comes up. (Clinicians)... have been disillusioned with this kind of approach for decades. We have the leadership capacity, but politicization doesn t allow us to row in the same direction.
9 PHSI (1): Key takeaways for decision makers: Leadership matters key to organizational and system performance (esp. primary care reform). Common leadership platform required LEADSpreferred or LEADS-compatible. Pan-Canadian Action Required leadership without ownership opportunity (CHLNet). Forces of fragmentation are winning system more disjointed; performance lacking (cite: most recent Commonwealth study) Missing Link distributed leadership and designated responsibilities. **Stay tuned for PHSI (2)
10 On the Leadership Policy Front Toward a Canada Health Leadership Action Plan? CHLNet leadership without
11 Despite our efforts, there is a skill gap Creating large scale change requires high levels of systems thinking, strategic thinking, visioning, engagement and selfleadership. The strategy that is being employed is insufficient; (change) just moves at a snail s pace 84% of all respondents say there is a small to large skill gap in leadership. CHLNet Benchmarking study
12 Benchmarking Results
13 Benchmarking Results
14 Toward a National Health Leadership Action Plan CHLNet is promoting greater coordination of leadership succession planning & talent management. It should link to Canada s reform agenda. Gone to CHW (June 14) Enroute to CDM (TBC) Current leadership culture needs a basic refresh. There is not a great value placed on health management and administration in this country.
16 Activity Plus ca change What s changed since Dec 2010? Much has changed! What hasn t changed? Health PEI Experiment seems to be working Contrast with other jurisdictions (e.g. AHS)
17 Activity LEADS as a Change Model: Aligning action Aligns action through a focus on results Achieve Results Aligns people and organizations through relationships Engage Others Develop Coalitions Outlines how to reassert alignment when change happens Lead Self Systems Transformation Clinicians Leaders Patients Managers Health PEI From a Caring Perspective...
18 Activity: Sharing the secrets of success Reflecting on your Health PEI experience over the past four years What do you think have been the critical success factors in helping PEI succeed in the Experiment? What advice might you offer other jurisdictions? What remains to be done in terms of taking Health PEI to the next level of performance?
19 The Merger! (1 +1 = 3)
20 Investing in an Integrated LEADS-based Curriculum of Courses Developing Leadership at All Levels: Modern Management Essentials Quality and Patient Safety Governance Development Program Integrated delivery channels: Topical Webinars every 3-4 weeks Flexible Learning Pathways Online/distance education
21 Partnerships Bring Learning to Life CPSI and Atlantic Health Quality Patient Safety Collaborative (AHQPSC) CPSO Hybrid IWK creo comprehensive research education online Accreditation Canada Integrated Quality Management
23 Thank you For more information About HealthcareCAN Contact:
24 LEADS Leadership as the "Source Code" for System and Organizational Performance Graham Dickson (PhD) Research Advisor, Canadian Society of Physician Executives, and Policy Advisor, Canadian Health Leadership Network Professor Emeritus, Royal Roads University
25 Approach A refresh on LEADS. LEADS as source code. Current research that validates LEADS. Who is using LEADS? How is LEADS being used?
26 A Refresh on LEADS
27 What is its evidence-base? Construct validity Two documented in-depth studies PHSI (CIHR/MHSRF) Face validity Appeal Utility
28 When, and why was LEADS developed? Leadership gap Fragmentation of effort : Three stages of development We are here
29 LEADS in a Caring Environment L Lead Self E Engage Others A Achieve Results D Develop Coalitions S Systems Transformation
30 LEADS clarifies the priorities for change... LEADS helps you answer these questions...in relation to your leadership challenge. R: What results do you want to achieve? R: What relationships do you have to build? C: What change challenges do you have to deal with?
31 You can influence the system...
32 LEADS as Source Code
33 LEADS as source code We see the five LEADS framework domains and twenty capabilities as the source code of leadership, a single common DNA base that allows for permutations and combinations that give expression to the individuals we are.
34 Being, Caring, Doing...
35 LEADS as source code LEADS takes expression in different situations and circumstances, contingent on the leadership needed. Leaders Doing LEADS It is an artful, thoughtful, and generative process. Leadership is the link
36 Contingency Leadership
37 Leadership requires alignment Alignment of personal leadership, interpersonal leadership, and strategic leadership creates the sweet spot change.
38 Directions (Part 1): 1. Review all domains of LEADS. 2. Rate the progress of health reform in PEI from 1 (completely stalled) to 10 (couldn t be progressing better). 3. If you had to choose one domain of LEADS that you would like to see you and all your colleagues emphasize to move your rating upwards, what would it be? Why? Activity: LEADS
39 Activity: LEADS Directions (Part 2): 1. Get up from your seat. 2. Move around and introduce yourself to someone you don t know. Share your ratings and the LEADS domain you have identified. 3. There will be three rounds of discussion, each 3 minutes long.
40 Current Research & LEADS
41 Recent Study: The importance of relationships Physicians and hospital administrators Key to success Yet meaningful differences Sr. management more satisfied than mid-man Hospital admin more than physician leaders Mid-level physician leaders least satisfied Engage others: Communication and teamwork Atefeh, 2014 in press
42 The Value of LEADS Common language: Leadership is the golden thread that runs through any discussion of NHS reform and improvement. This encompasses leadership by doctors and other clinicians; leadership by managers of NHS organizations, and leadership by politicians at a national level (Ham, 2014)
43 Despite our efforts, there is a skill gap Creating large scale change requires high levels of systems thinking, strategic thinking, visioning, engagement and selfleadership. The strategy that is being employed is insufficient; (change) just moves at a snail s pace 84% of all respondents say there is a small to large skill gap in leadership. CHLNet Benchmarking study
44 We need more physician leadership (We need the)...courage to crack the clinical leadership black box. Go after those clinical leads. They are the wave of the future Straddling the line between doctor and leader Quality physician leadership at all levels is required; exemplary practices of ongoing, meaningful physician engagement are needed.
45 Churn creates fragmentation of effort Someone gets excited about something and then they get fired or they move on and then the next new shiny thing comes up. (Clinicians)... have been disillusioned with this kind of approach for decades. We have the leadership capacity, but politicization doesn t allow us to row in the same direction.
46 Our mindsets will have to change Change challenges conventional notions of autonomy, accountability, and collaboration. NHS: First Patient Safety Ombudsman....if we can just park our collective egos and get out of this passive aggressive nature and work as a collaborative we could be stronger.
47 Many experience change Fatigue Canada s leaders are having their energy drained and not refreshed. Some leaders report they don t have the energy or stamina or stomach to do it ever again they get hammered by the premier's office, the minister's office, the unions, local newspapers, the people who donate to the hospital, the foundation, the public. Everybody believes that change is for the worst.
48 Contradictions exist within the system due to change itself and the conditions that both create and impede change. Contradictions paralyze us
49 Contradictions (cont.) Contradictions are differing perspectives, or ways of seeing the world that appear to be opposed to one another.
50 Contradictions (cont.) When entrenched as sides in a dispute, contradictions create negative conflict, which either stalls or mitigates concerted energy. When contradictions are not explicit, but real, they can lead to inconsistency of effort, and stalls personal or collective action.
51 Activity: Contradictions Directions: 1. Think of a contradiction that exists within your leadership role. 2. Pair up with someone you don t know. 3. Discuss those contradictions and how to deal with them productively.
52 But there is hope!
53 CHLNet National Action Plan A national perspective on health matters could be exercised by the provinces acting in collaboration, possibly without a strong federal presence. To date, little...has been accomplished on health reform by the Council of the Federation, and under their organizational structure this shouldn t be expected to change... Realistically, over the next several years, health policy reform will for the most part have to proceed with individual provinces. This may not be ideal, but it need not be a showstopper. It could, in fact, work quite well. (Drummond, 2014)
54 Individuals: Who is using it? Executive Officer Margret Comack, BN, Med. A Journey of Leadership From Bedside Nurse to Chief. Nurs Admin Q, Vol. 36, No. 1, pp Understanding leadership from the inside out was a journey that spanned a 40-year career in health care. This article describes an individual s journey of becoming an effective executive leader using the LEADS in a caring environment capabilities framework.
55 Who is using it? Organizations: Hamilton Health Sciences (succession planning) Horizon Health: Leadership development (TTT) Eastern Region of Newfoundland (mid-management development) Saskatchewan, Manitoba: provincial leadership programs Alberta: Senior executive program in collaboration with U of A; ACFP for Primary Care Network implementation BCHALDC: BCHLDC created Leadership LINX, a Provincial Pathway of Leadership Development with 5 key areas: coaching, mentoring, new manager, experienced leader & senior leader.
56 Who is using it? Nationally, Internationally LEADS Collaborative CHLNet members Australia Reviewed in Italy, Netherlands Health LEADS Australia New South Wales
57 The LEADS Collaborative CORE BUSINESSES DEVELOPMENT BUSINESS MANAGEMENT PARTNERSHIPS CLIENTS KNOWLEDGE CENTRE FRAMEWORK LEADS IN A CARING ENVIRONMENT A Foundation for Professional Growth CODE OF ETHICS A Foundation for Ethical Behaviour
58 How is it being used? Example: CMA Physician Management Institute s Open Enrolment and Inhouse programs PMI Physician Engagement: The LEADS framework is helping me to identify the capabilities necessary for leadership. Percentage Count Yes, 100.0%
59 Additional uses... Personal development Curriculum guide (e.g., BC HA entrylevel program) Succession Planning Leadership development programs Guiding leadership of health reform 360s, coaching and personal growth Research
60 For more information on LEADS... or
62 Courtyard Cafe
63 One question for four tables (next slide). Three rounds of fifteen minutes each. You get to answer three questions. Pick the ones important to you! Move as individuals. Waiter (recorder) at each table. Record notes on sheets provided. Random debrief. Directions
64 Questions LEADS can assist with leadership talent management (e.g., succession planning, broad organization-wide leadership development, performance expectations, etc.). What guidance would you give about how it can be used effectively to support these initiatives? What pitfalls should be avoided? (Tables 1-4) LEADS outlines leadership expectations for people in all leadership roles from front-line supervisor to board member. Are you clear on what those expectations are for your role? How might PEI Health make these expectations clear enough for you? Would doing so be helpful? (Tables 5 8) Chris Ham, from the King s Fund in the UK, states that: Leadership is the golden thread that runs through any discussion of NHS reform and improvement. This encompasses leadership by doctors and other clinicians; leadership by managers of NHS organizations, and leadership by politicians at a national level. Do you agree with this statement, particularly in the sense of using LEADS as the common language for leadership for all partners in reform in PEI? Why or why not? (Tables 9 12) The PHSI research and research by others suggests that health reform in Canada has progressed very little over the past 15 years, despite a strong public consensus that the system must change to be more patient and family centred From your perspective, can LEADS be used, realistically, to help you envisage and plan to do patient-centred leadership of change better, in your formal leadership role? If so, how? If not, why not? Explain. (Tables 13 16) As part of PEI s leadership development process, you may be asked to undertake a LEADS 360 assessment. What are the reasons for doing a 360? How should it and the debrief be conducted so as to get the maximum benefit for your own development? What are the pitfalls of a 360 process that should be avoided? (Tables 17 20)
65 Thank you For more information about LEADS, contact: Graham Dickson Brenda Lammi
66 A Role Dialogue Move to tables with people in the same role as you board member, midmanager, executive, etc. Discuss the questions on the next slide.
67 Is LEADS applicable to the leadership challenges you face in your role in PEI Health? Why or why not? To make it more applicable, what would have to happen? Is a common language valuable for leadership, for all different groups in the system, when it comes to implementing health reform? Would you recommend that different groups learn leadership together, or in separate groupings, based on their specific role? A Role Dialogue
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About the Book
This is a group of nearly 300 images captured at the Webster County Woodchopping Festival in Webster Springs, West Virginia May 24-25 2008. There were competitors from several countries as well as local athletes. There was exciting competition as well as wonderful weather. The beautiful scenery of this area is a bonus. This venue is highly recommended.
Features & Details
- Category Sports & Adventure
Standard Landscape, 10×8 in, 25×20 cm
80 Pages
- Publish Date May 28, 2008
- Tags west virginia, woodchoppers, festival
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subset: commoncrawl


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Despite heavy expectations about a potential trade, the New England Patriots held onto the first Friday pick in the NFL draft and chose CB Ras-I Dowling of Virginia.
Dowling will add yet another young, physical defender to the Patriots' backfield. He'll join Devin McCourty, a first-round pick from last season.
But his selection was a bit of a surprise in that many analysts expected the free-wheeling Patriots to deal the pick.
Head coach Bill Belichick was on ESPN about 20 minutes before the pick saying that quarterback derby was on among teams trying to trade into the 33rd overall spot.
NFL Network analyst Mike Mayock praised the pick, while noting that Dowling has comes with durability concerns.
"They're just going to get better on defense," Mayock said.
Nate Davis is a reporter, blogger and editor who's been at USA TODAY since 2000. He has covered the NFL since 2005. No, he did not play quarterback for Ball State. Davis' succession of our esteemed colleague Sean Leahy at The Huddle is considered a Brady-for-Bledsoe swap by most "insiders."More about Nate


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ICoMST International Congress of Meat Science and Technology
The scope of the ICoMST is to enhance the co-operation and scientific information between the academic and industry researchers in the field of meat science and technology. The Congress meetings focus on presenting the latest findings in specific scientific disciplines, critical reviews of the work done in the various fields as well as up-dating the latest knowledge on current issues most relevant for meat as food.
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Place Your Bets Now: Batteries, Biofuels Or Natural Gas
After hearing a few executives of biofuels start-ups expound on the benefits of their technologies, David Demers, chief executive of Westport Innovations Inc., dismissed them wholly.
"We won't have any need for you guys, making replacements for crude oil," said Demers. Why? Because Demers believes natural gas – which is cheaper than new biofuels, much more abundant in North America, and far cleaner than crude oil – will take over in the gas tank. Westport makes internal combustion engines that can operate on gaseous fuels such as natural gas, biomethane and hydrogen. Demers and others were speaking on a panel at the Lazard Capital Markets' Alternative Energy Investor Summit on Wednesday in New York.
In some countries, noted Matthew Beale, president and chief financial officer, of Fuel Systems Solutions Inc., another natural gas-for-vehicles company, natural gas accounts for 20% of the fuel used for vehicles on the road. And adopting an engine that runs on gasoline to using natural gas is fairly easy. Manufacturers, such as Ford Motor Co. and General Motors Co., are already producing many vehicles that can run on both types of fuels.


text:
Eukaryotic Protein Kinases (ePKs) of the Helminth Parasite
Schistosomiasis remains an important parasitic disease and a major economic problem in many countries. The
We have identified 252 ePKs, which corresponds to 1.9% of the
Our approach has improved the functional annotation of 40% of
Human schistosomiasis caused by blood fluke parasites of
The maintenance of homeostasis and complex cellular adaptations in
Protein kinases (PKs) play a central role in mediating intracellular signals by adding a phosphate group from ATP or GTP to an amino acid residue leading to a conformational change in the target protein that will switch its activation status
PKs are classified into two superfamilies containing the eukaryotic or conventional protein kinases (ePK) that share a conserved catalytic domain, and the atypical protein kinases (aPKs) (Table
Table 1
Protein kinase classification
Serine/Threonine Kinases
Eukaryotic Protein Kinases (ePKs)
Tyrosine Kinases
TK like
Protein kinases are broadly classified into two major superfamilies (ePKs and aPKs). The ePKs groups, families, and subfamilies adopted in the present work followed the proposed hierarchy described elsewhere
PKs are considered druggable targets from the medical and chemical viewpoints as a growing number of PKs inhibitors have been developed and approved for treatment of different human disease
The current schistosomiasis treatment frequently does not cure 100% of those treated in high-risk communities and the emergence of
Results and discussion
The ePK complement of
Figure 1
ePKinome in the predicted proteomes of diverse taxa
ePKinome in the predicted proteomes of diverse taxa. A total of 252 PKs were identified in the predicted proteome of
Amino acid sequences corresponding to the conserved catalytic domain of ePKs were aligned by MAFFT
Additional file 1
Eukaryotic protein kinases of
Click here for file
As shown in Figure
Figure 2
Distribution of ePKs groups in
Distribution of ePKs groups in
Of the 252 ePKs identified in
Approximately 2% of the
Serine/Threonine kinases
AGC group
Around 13 families have been classified as part of the AGC group in eukaryotic organisms
Additional file 2
Phylogenetic analysis of the AGC group. Amino acid sequences of the catalytic domain of the AGC proteins of
Click here for file
The most significant difference between PKA and PKG family members is that in PKA, the regulatory and catalytic activities are performed by separate gene products known as PKA-R and PKA-C, respectively, whereas in PKG the cNMP-binding (cyclic nucleotide-binding domain) and catalytic domains are usually present in the same polypeptide
PKC belongs to a large protein family that is classified into four important subfamilies: PKC Alpha subfamily, that contain the conventional PKCs (γ, βI, βII, and α) and are sensitive to diacylglycerol (DAG) and Ca2+; PKC Eta and Delta subfamilies containing the
One protein in AGC group, Smp_157370, remains unclassified. In the phylogenetic tree, this protein appears more closely related to the GRK (G-protein coupled Receptor Kinase) family (Additional file
Interestingly, according to SchistoDB
CaMK group
The divalent cation calcium (Ca2+) is one of the ions most widely used as a second messenger in cellular signaling. A significant portion of calcium-mediated signaling is controlled by calmodulin-binding kinases. Some members of the CaMK group are dependent on the binding of Ca2+/CaM
Additional file 3
Distribution of some ePKs Families in
Click here for file
Additional file 4
Phylogenetic analysis of the CaMK group. Amino acid sequences of the catalytic domain of the CaMK proteins of
Click here for file
MLCK is a Ca2+/calmodulin-dependent protein kinase whose only known substrate is myosin II regulatory light chain
DCAMKL (Doublecortin and CaMK-like) is a protein that regulates the microtubule cytoskeleton and in the chick is specifically expressed in the developing brain
While the CaMK2 (CaMK family 2) family is encoded by four genes in humans, only a single CaMK2 gene, with two predicted alternative spliced transcripts, was identified in the
CMGC group
CMGC kinases are relatively abundant in
Additional file 5
Phylogenetic analysis of the CMGC group. Amino acid sequences of the catalytic domain of the CMGC proteins of
Click here for file
GSK family is represented by 3 proteins in
The MAPK signaling pathways are some of the best characterized signaling systems.
Figure 3
MAPK signaling pathway
MAPK signaling pathway. MAPKs are expressed in all eukaryotic cells and are activated by diverse
STE group
Additional file 6
Phylogenetic analysis of the STE group. Amino acid sequences of the catalytic domain of the STE proteins of
Click here for file
Table 2
Orthology relationships among ePKs of
C44C8.6_Ce e K08F8.1
Embryonic Lethal
Embryonic lethal, maternal sterile, organism morphology variant.
Larval lethal, fertility reduced
Body morphology defect, slow growth
Embryonic lethal, sterile, body morphology defect
Embryonic lethal, body morphology defect
Smp_026510, Smp_151670
Embryonic lethal, sterile, reduced brood size, exploted through vulva, slow growth
cortical dynamics defective early embryonic, maternal sterile
Abnormal cell migration, protruding vulva, developmental delay
Embryonic lethal, body morphology defect, slow growth, sterile, larval lethal, dumpy
More depolarized oocytes
Slow growth, larval lethal late L3/L4
Embryonic lethal, body morphology defect, larval lethal, sterile,
paralyzed, uncoordinated movement, paralyzed
Sterile, osmotic integrity problems
Embryonic lethal, slow growth, sterile progeny, uncoordinateed movement
Embryonic lethal, larval lethal, maternal sterile
Locomotion variant, larval lethal, sterile progeny
pmk-1_Ce, pmk-2_Ce
Apoptosis increased, sterile progeny, reduced brood size, embryonic lethal
Smp_134260, Smp_133490, Smp_133500
Reduced brood size, embryonic lethal
embryonic lethal, sterile progeny
Smp_155720, Smp_125310, Smp_008260.1
Y18D10A.5_Ce, C44H4.6_Ce
Larval lethal, slow growth, embryonic lethal
B0495.2_Ce, ZC504.3_Ce
Embryonic lethal
Embryonic lethal, slow growth, uncoordinated movement
Embryonic lethal
Smp_140700, Smp_074080
Embryonic lethal, larval lethal
Embryonic lethal, sterile progeny
Orthology relationships were inferred based on phylogenetic trees. RNAi phenotype for
CK1 Group
The two smallest groups found in the
Figure 4
Phylogenetic analysis of the CK1 group
Phylogenetic analysis of the CK1 group. Amino acid sequences of the catalytic domain of the CK1 proteins of
Tyrosine kinases
TK group
PTKs can be classified, based on the presence or absence of transmembrane domains, into receptor tyrosine kinase (RTK) that relay intracellular signals
Two InsRs in
Additional file 7
Phylogenetic analysis of the TK group. Amino acid sequences of the catalytic domain of the TK proteins of
Click here for file
The CTKs in
RGC group
Proteins in this group share sequence similarity to the catalytic domain (Pfam: PF07714) found in proteins of the TK group
Additional file 8
Phylogenetic analysis of the RGC group. Amino acid sequences of the catalytic domain of the RGC proteins of
Click here for file
Hybrid protein kinase
TKL Group
TKL consists of a divergent group that is phylogenetically close to the tyrosine kinases (Figure
Additional file 9
Phylogenetic analysis of the TKL group. Amino acid sequences of the catalytic domain of the CK1 proteins of
Click here for file
A STKR member that binds to TGFβ (Transforming growth factor) is a membrane receptor that can be divided into two subclasses (Type I and Type II). The type II receptor binds TGFβ and then recruits the type I receptor. The TGFβ type I receptor was cloned in
Other Group
The Other group consists of a mixed collection of kinases with representatives in higher eukaryotes, including SCY1, NEK (Mitotic Kinase family, also known as NRK), PEK, Haspin, WEE, NAK (Numb-Associated Kinase), ULK (Unc-51 Like Kinase), IRE (Inositol Requiring), PLK (Polo Like Kinases), AUR (Aurora Kinase), and CDC7 (Cell Division Control 7) families (Additional file
Accessory Domains
The structure of the catalytic domain of many ePKs is highly conserved across distinct organisms because of the fact that all ePKs recognize and bind ATP at common sites. However, only the catalytic domain (architecture/sequence) is sufficiently divergent to enable the discrimination of groups, families, and subfamilies (Figure
Figure 5
Phylogenetic analysis of the paralogous ePKs groups of
Phylogenetic analysis of the paralogous ePKs groups of
Most ePKs also have a second domain that is involved in protein-protein interaction and allosteric regulation of the catalytic domain
The analysis of the sequence domain data from Pfam
Figure 6
Figure 7
Accessory Domains
Accessory Domains. Representative domain organizations of some
The most common Pfam accessory domains found in
More than 40% of
CASK is a member of the CaMK group and plays a key role in establishing inter-cellular contacts and plasticity at cellular junctions
The CMGC and CK1 groups have none or a few accessory domains in
PBD (p21-Rho-binding) and C-terminal CNH domain are usually found in the STE20 families (Figure
The SH3 and SH2 (Pfam: PF00018 and PF00017, respectively) domains are common found in CTK proteins. SH2 function as regulatory modules of intracellular signaling cascades and it was found in eight out of 19
In conclusion, the protein architecture, including the accessory domains, may indicate potential protein partners. Signaling roles of schistosome specificities or unusual architectures are of special biological interest.
This study allowed us to identify and classify 252 ePKs encoded in the predicted proteome of
Table 3
After phylogenetic analysis
Number of changes
% of
Change group classification
Change family classification
Add subfamily
Classification of unknown proteins
Total of changes
Through phylogenetic analysis, we have improved the functional annotation of 40% of
Organisms and Sequences
Functional Classification
Functional classification of protein kinases into groups, families, and subfamilies followed the proposed hierarchy described elsewhere
Hidden Markov Models
In order to identify potential homologs in
Phylogenetic Analyses
Amino acid sequences corresponding to the conserved catalytic domain (Pfam: PF0069 or PF07714) of each group of protein kinases were separately aligned using the default parameters of MAFFT
ATP: adenosine triphosphate; cAMP: cyclic adenosine monophosphate; GTP: guanosine triphosphate; NCBI: National Center for Biotechnology Information; RNAi: RNA interference.
Authors' contributions
LFA: carried out the functional annotation and phylogenetic studies, and drafted the manuscript. LAN: designed the phylogenetic studies, performed preliminary phylogenetic studies, coordinated the functional prediction, and co-wrote this manuscript. LGAV and LLS carried out the functional annotation based on sequence similarity search using HMMs. AZ wrote the Perl scripts for data manipulation and provided computational support for this study. JCR designed and performed the HMMs analysis. GO participated in the design and coordination of this study, and co-wrote the manuscript. All authors read and approved the final manuscript.
This work was funded by the National Institutes of Health - NIH/Fogarty International Center (PPM-00439-10 to GO), Secretaria de Ciência, Tecnologia e Ensino Superior de Minas Gerais, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, SECTES/FAPEMIG, Brazil (CBB-1181/08 and PPM-00439-10 to GO), and Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq (CNPq-Universal 476036/2010-0 to LAN, CNPq-INCT 573839/2008-5 to GO, and INCT-DT 573839/2008-5 to GO). LFA is a fellow of FIOCRUZ. The authors acknowledge the use of the computing resources of the Center for Excellence in Bioinformatics, CEBio/FIOCRUZ, Brazil.
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Deflect-O® DuraMat Lightweight Chairmats; 46x60" Overall, 25x12" Lip
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Larry's Tours and Charters
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Featuring: Luke Treadaway, Sophie Wu and Ruta Gedmintas
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Can a pair of handcuffs turn a pair of enemies into lovers? Adam (Luke Treadaway) is the lead singer with successful retro-pop group The Make, who are booked to headline a high-profile music festival in Scotland. Adam arrives at the festival with his keyboard player Tyko (Mat Baynton) and socialite girlfriend Lake (Ruta Gedmintas), but while trying to track down his manager, he happens upon Morello (Natalia Tena), the frontwoman for the all-female punk band The Dirty Pinks. Morello doesn't think much of Adam and his music, and the feeling is mutual on his part; the two are soon engaged in a fierce argument that attracts the attention of a renegade preacher attending the festival. To teach them a lesson about cooperation and compromise, the preacher handcuffs Adam and Morello together and then throws away the key. Stuck with one another until they can find a locksmith, Adam and Morello are not at all happy with this arrangement -- especially since it means performing together on stage -- but as the day wears on, the two musicians find they have more in common than they thought, and Morello begins to wonder if she's really happy with her boyfriend Mark (Alastair Mackenzie). You Instead was shot on location at the ground of Scotland's annual T In The Park music festival, with most of the scenes filmed while the event was taking place.
Release Date: 06 February 2012
Certificate: TBA - To Be Announced
Actors: Luke Treadaway, Sophie Wu, Ruta Gedmintas and Natalia Tena
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Mohali: Make shift opener Deep Dasgupta justified the faith reposed in him to remain unbeaten on 71 as India reached 150 for two at tea on the second day of the first Test on Tuesday. Rahul Dravid was unbeaten on 34 at the other end.The Indian batsmen continued to grind the English bowling in the post lunch session. Both opener Deep Dasgupta and Rahul Dravid played with utmost caution. They played the patient game to a nicety and never embarked on any risk.The English bowlers failed to get any help from the wicket, which was getting slower by the day. The Indians, who had added 55 runs in 30 overs in the first session, scored 71 runs off 29 overs in the second session without losing any wicket.India lost the wicket of night watchman Anil Kumble to debutant off spinner Richard Dawson in the morning session. Anil Kumble tried to cut Dawson and was well taken by debutant wicket-keeper James Foster.Kumble scored 37 runs with four hits to the fence and added 54 runs for the second wicket.Wicket-keeper Deep Dasgupta, who has opted to open the innings, played a very patient knock as the English bowlers failed to make any impression. Though the scoring rate was very slow, the Indians managed to keep their wickets intact.
India reaches 79/2 at lunch on day 2
England's tour of India


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Family house, Sale, Nové Mesto nad Váhom, Slovakia
56.000,00 €
Family house, Sale, Brunovce, Num. ZR-138138
We sell a 3 bedroom house in original but very good condition, with a total land area of 2,181 square meters, located in a quiet area of the village Brunovce - Nové Mesto nad Váhom. The house has a spacious entrance hall with seating and the hall there is a cellar, pantry, bathroom with toilet, kitchen, 3 rooms, the house includes a newly built a summer kitchen, garage and a large well-kept garden - the possibility of building a new house.
Advantages: sunny, nice view, quiet surroundings, good amenities, walking, cycling, sports, fishing - is located near the river Vah, about 10 minutes. car spa town of Piestany.
Legal and consulting services free of charge, the possibility of a mortgage loan. Agent Phone 0905 485 220, 0944 infoline 543,222th
Listing summary
2181 m²
2181 m²
350 m²
personal property
original condition
Real Estate Agency 253 offers
DS Reality, s.r.o.
Mierové námestie 5A
Trenčín 911 01
0903 370 805
0944 543 222
Real Estate Agent 115 offers
Ľubomír Stopka
0905 485 220
Your Listing seems interesting, please contact me.
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Family house, Sale, Nové Mesto nad Váhom, Slovakia
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Lyme's Disease is a crippling disease that has baffled doctors since it was first reported in 1975.
The disease causes nerve damage, pain, numbness, and even paralysis. It is spread by deer ticks who feed on both animal and human blood. Unbelievably enough, new evidence suggests that Lyme's Disease was created by our own government.
The first case of Lyme's Disease was reported in Old Lyme, Connecticut back in 1975. Not even ten miles away from this town is the Plum Island Animal Disease Center, which happens to have a tick research lab.
If this isn't enough of a coincidence for you, there's still much more evidence to come.
After World War II, Plum Island recruited noted Nazi Erlich Traub to do research there. Traub worked directly under Hitler during the war, and he narrowly escaped standing trial in Nuremberg for his crimes. Traub was a top biological weapons industry expert whose specialty was infecting ticks and mosquitos with biological germs.
Reports say that Plum Island allowed the infected insects to roam the island freely. Meanwhile, boats, birds, and people travelled on and off the island, making it easy for ticks to escape and spread the disease.
This basically means that Lyme's Disease was created by our own government and spread around the country due to their thoughtlessness. Since 1975, this disease has spread like wildfire.
Now, Plum Island is for sale, despite the fact that it contains thousands of creatures infected with an unimaginable variety of diseases, and evidence suggests that Lyme's Disease is nothing compared to some of the others.
In 2008, the Montauk Monster washed up on the beaches of Montauk, New York. The creature had long fingers and puncture wounds in it's skull. Rumors quickly spread that the creature was another Plum Island "experiment."
An unidentified human remain washed up on shore soon after as well, making this story all the more sketchy.
If something is not done about Plum Island fast, we could all be in big trouble.


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Laboratory Perfumes
No. 003 Samphire Eau de Toilette 100ml
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FLEXO Magazine : August 2008
PLANTS & PROCESSES ishes on any label and when a promise is made to a customer, it is committed 100 percent. This demand usually leads to slower press speeds, longer setups, and the willingness to perform con- stant R&D as different designs come in. Wineries love to push the limits of printing. Paragon follows methodical and rigid procedures to ensure that its customers' labels are always of the highest quality. This requires different steps from the time a label is run all the way through subsequent re-runs. In fact, it is very rare that a re-run is a simple repeat. Usually the labels will change vintage dates, which require new plates for every run. On most first-time runs, management encourages a press check with either the customer or its graphic designer. This elim- inates any guesswork and ensures that the fi nal label is exactly what the customer envisioned. In some cases, press operators are matching previously printed samples that were produced via off- set or from another fl exo printer, a challenge that usually requires an in-house press check to guarantee customer satisfaction. Once a standard is set and the label is signed off for approval, a specifi- cation card will be written that includes information on the sub- strate, anilox rolls, inks/varnishes, plate material types and even the stickyback used by the press operator. A customer-signed master sample, is then attached. The spec card also lists what to watch for, such as color or any special processes and materials that were used to make the job run more effi ciently. This card is fi led and saved and referenced every time the label prints or until the specs change. Once the job is ready to run, stock and colors will be checked and the copy and text will again be proofread against the proof signed by the client. The die cut will also be checked for fi t and any scoring of the liner. If the liner is scored too deep, it can cause label applications issues on the bottling line. Then a rub test will be performed. The rub test will be used throughout the run to make sure that the label is able to withstand packaging and shipping, so it looks as good on the shelf as it does fresh off of the press. The fi nished label will then be checked by either the general man- ager or lead press operator, who will use a precise check- list to ensure that every quality aspect has been checked. Apart from general print quality, wineries also are very time- Paragon's 110,000 square ft. Petaluma, CA corporate headquarters and printing plant (shared with Mrs. Grossman's). sensitive when it comes to labels. In almost all cases, the wineries are working with mobile or fi xed bottling lines that are constantly booked and heavily staffed. On top of that, the wine is placed in storage tanks during bottling, where there is a small and very precise window of time when the wine can be bottled. This al- lows for no missed days or huge damages and expenses. Running shiners (fi lling the bottles and labeling them afterwards) can cost thousands of dollars and the wineries are more than willing to pass that cost onto their label producers. To deal with this vari- able, Paragon has to be fl exible with its production schedule and willing to work closely with its customers, so they get the labels they want in a timely, cost-effective manner. Another huge area of concern to Paragon's customers is the physical characteristics of the label. Wineries love foil stamp- ing, embossing and un-coated and specialty stocks with specific adhesives and durable liners that can stand high-speed applica- tion. This means no stock substitutions and a constant monitor- ing of the stocks that come in from their suppliers. Many wine labels have to withstand immersion in ice buckets, which causes FTA Narrow Web Best of Show 2006: Paragon Label www. f l e x o g r a p h y. o r g AUGUS T 20 0 8 F LEXO 75
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In the mid-1980s, a little known Missouri-based writer and painter named Gladys Swan sold to a major New York publisher the first of what would become a five-book saga about a down-and-out but courageous traveling carnival. Filmmaker Victor Nunez, struck by the grittiness of the characters and the high-octane energy of these eccentrics battling to entertain and survive, optioned Carnival for the big screen and wrote a full screenplay. Nunez s film was never made. But now here is Swan's first book, a work that captures with stunning authenticity a uniquely American landscape.
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Для получения актуальных цен по гостинице Hotel Roma, пожалуйста, укажите интересующие вас даты и выполните поиск.
With a stay at Hotel Roma in Cesano Boscone (Southern Milan), you'll be close to Parrocchia Sant'Ambrogio Trezzano and San Siro Stadium. This 4-star hotel is within close proximity of San Carlo Borromeo Hospital and Domus Academy.
It is set near Milan and can be easily reached by any transportation thanks to its closeness to the main highway junctions and it offer a mini bar, satellite LCD TV, air conditioning, FREE WIFI access
Заезд: 12:00
Выезд: 11:00
Раннее заселение и поздний отъезд по возможности (услуга может быть платной).
Построена в 1960 году
Этажей: 4
Номеров: 34
|Описание номеров
|Make yourself at home in one of the 34 air-conditioned rooms featuring minibars. Rooms have private balconies. Complimentary high-speed (wired) Internet access keeps you connected, and satellite programming is available for your entertainment. Private bathrooms with bathtubs or showers feature complimentary toiletries and bidets.
Rec, Spa, Premium Amenities
Make use of convenient amenities such as complimentary wireless Internet access, concierge services, and babysitting/childcare (surcharge). Additional amenities include a television in the lobby and tour/ticket assistance.
Take advantage of the hotel's 24-hour room service. Quench your thirst with your favorite drink at a bar/lounge.
|Бары и рестораны
|Buffet Breakfast.
|Обратите внимание
|Featured amenities include complimentary high-speed (wired) Internet access, a business center, and dry cleaning/laundry services. A roundtrip airport shuttle is provided for a surcharge (available on request), and self parking (subject to charges) is available onsite.


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- Doctors
- New York
- West Islip
- Gynecologists
- Dr. John J. Vullo
You may also like
Dr. Howard R. Egre
Ratings for Dr. John J. Vullo
Dr. Vullo goes above and beyond for his patients. The care recieved is not easily matched. If your looking for a top notch dr look no further, this is the place to go. Honest, compassionate, and thorough. I will forever be grateful for his care during my pregnancy, and beyond.
dr vullo is the best! His office and staff always go above and beyond! Dr. Vullo delivered my last baby and by far has been the best obgyn of all 3 of my deliveries! His quick thinking and knowledge saved my daughter during childbirth! His beside manner is amazing, so caring and compassionate!
I made an appointment with dr.Vullo. Unfortunately never got to meet him. When i went there i didn't see any doctors in that office! Only a nurse practitioner. (Staff SHOULD ASK IF YOU ARE "OK" SEEING A NP INSTEAD OF A DOCTOR). NP did a pop test, and also gave me an infection! So i called them back (i had another appointment for sonogram) and asked to see a doctor to talk about it. The girl said: "Come for a sonogram and we will see what we can do for you then.." I said: "If i will not see the doctor i do not wish to keep the appointment". She kept on telling me to come.. i kept on telling her that i wanted to see the doctor.. so then, She put me on hold. I was so upset, i hand up. Another girl called me the next day angry that i didn't show up for my appointment.. I explained what happened. She said that; because i never showed up for the appointment i was no longer a patient of that office.. :-O I got "KICKED OUT" FOR WANTING TO SEE THE DOCTOR AFTER GETTING AN INFECTION IN THAT OFFICE!!! THINK TWICE BEFORE GOING THERE!
He is I will say one of the best doctors in Long Island .I went there for the first time when I was pregnant with my first since I didn't know what to do and I was desperate .So my friend recommnded them to me so I went and I can say it was the best doctors I have ever seem all 4 of the are good. But Vullo and Ketcham are the bests. I didn't get Vullo to deliver my baby but I got Ketcham to do it and it was awesome.. I highly recommend them !!
He IS a good doctor--but sometimes, that's the challenge: Everyone wants to see him, and between his work at nearby Good Sam and his popularity, sometimes you have to wait a few weeks for an appointment. However, he's worth it. Compassionate bedside manner, will call you himself in the evening (which I prefer, instead of while I'm at work, where people can overhear), stays up-to-date with medical research, and considers your *complete* family history when recommending treatment, including second-degree relatives. His staff is good, too--when there was an issue with another doctor's bloodwork, they called the lab and got the results themselves. The waiting room is pleasant, and you're never sitting there for long. I'd highly recommend him.
Doctor Vullo is an amazing Doc he knows exactly what he is doing and is always on top of things.
Dr. John J. Vullo's Credentials
Facility Affiliations
Accepting New Patients
- New York College Of Osteo Medicine Of New York Institute Of Technology (Grad. 1990)
Other Specialties
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Top Gynecologists (OBGYN)
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Hey guess what? It is the last Friday of the month! Are you ready to link up your best projects, recipes and crafts? We are ready to see what you have been busy working on throughout the month of September. I am really getting into the Halloween mood so I can't wait to see what sorts of Fall and Halloween inspired projects you have created (or cooked)! Want to know what the other hosts and I have been busy doing?
As busy ladies the other hosts and I have decided to make our link party a monthly thing. Join us on the last Friday of each month to share your inspiring links from throughout that month! We can't wait to check our your links and


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BBQ for Leftovers
Recipe by LAURIE
This is so good for any leftover roast that you may have. I calls for 3 lbs but it can be halved to accomodate a smaller amount. Try it over noodles or mashed potatoes...
Top Review by KeyWee
This was very good ~ you can't really mess this up! I tossed it all in the crockpot and left it all day. It was great on warm rolls. The only substitutions I made were to use a large can of tomato sauce in place of the tomato paste (my husband likes a lot of sauce)and I didn't have any cider vinegar so just threw in a splash of balsamic. I used about a half a bottle of hickory-flavored bbq sauce. We had leftover pork roast and I would definitely make this again!
Ingredients Nutrition
- 2 tablespoons butter or 2 tablespoons gravy, from leftover roast
- 1 garlic clove, chopped
- 1 onion, chopped
- 1 stalk celery, chopped
- 1⁄4 cup catsup
- 1 -2 tablespoon tomato paste
- 16 -18 ounces barbecue sauce (1 small bottle)
- 2 tablespoons cider vinegar
- 1 cup tomato juice or 1 cup water
- 1 tablespoon Worcestershire sauce
- 3 lbs cooked beef roast or 3 lbs pork roast
Directions See How It's Made
- Saute is a large pan the butter/gravy, garlic, onion and celery, until tender.
- Cut meat into small cubes.
- Add meat and remaining ingredients into veggie mixture.
- Heat at least until warmed through, or let simmer for about 1 hour until slightly thickened.
- This also works well put into a crockpot on low for 4-5 hours.


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Squirrel Jokes and Other Episodes is a fan-fiction VHS/DVD Release featuring one SpongeBob SquarePants episode, one Thomas and Friends episode, one Dexter's Laboratory episode, one Codename: Kids Next Door episode, one Pokemon episode and one Rocket Power episode.
- Squirrel Jokes (SpongeBob SquarePants)
- No Joke For James (Thomas and Friends)
- Topped Off (Dexter's Laboratory)
- Operation: T.R.I.C.Y.C.L.E. (Codename: Kids Next Door)
- To Master The Onix-Pected (Pokemon)
- Reggie's Big (Beach) Break (Rocket Power)
- Distributed by USA Home Entertainment.
VHS/DVD Artwork
Front Cover
- Top: SpongeBob and Sandy
- Bottom: Gordon, James and Henry from "No Joke For James"
Back Cover
- Bruno from "To Master The Onix-Pected"
- Dexter and Dee Dee from "Topped Off"


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Deep garnet black color. Aromas of dried berries, clay, and chocolate yogurt with a supple, dry-yet-fruity medium body and a nice balanced cedar and nut accented finish. A very nice table wine that is a dead ringer for a fine Bordeaux red.