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Sportsbook.com attributes the growing popularity in online gambling to the endless betting options that exist, beyond just predicting who will win the game.
"Our team works very hard to deliver the most unique and interesting betting props for our players," said Alex Czajkowski, Marketing Director, Sportsbook.com. "When players bet online, the options are limitless and immediate, whether you're wagering on an individual player's performance or betting on live games as they happen it really raises the stakes and makes the games more exciting."
This weekend's Final Four offers many intriguing storylines and options for bettors. Will two Big Ten Conference Teams – Illinois and Michigan State – meet in the final for the first time since 1976? Will Rick Pitino, coach of Louisville, lead his second school to the championship after winning the 1996 title with Kentucky? Will North Carolina coach Roy Williams finally win his first championship after leading Kansas to four Final Fours?
Heading into the Final Four, Sportsbook.com has North Carolina as the favorite to win the title, with a showdown against Illinois the most likely scenario:
Odds to win the championship
North Carolina 3-2 (-230)
Illinois 2-1 (-155)
Louisville 7-2 (+135)
Michigan State 6-1 (+190)
Odds on who will meet in the final
North Carolina vs. Illinois $100 bet pays $136.04
North Carolina vs. Louisville $100 bet pays $237.17
Michigan State vs. Illinois $100 bet pays $377.09
Michigan State vs. Louisville $100 bet pays $581.50
A full list of odds and props can be found at www.sportsbook.com.


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The broad-ranging research at the University of Gothenburg is innovative, characterised by multidisciplinary cooperation, closely linked to education and stands in close contact with society. Our 2700 researchers, teachers and doctoral students span from developmental biology and gender studies to logistics and marine mammals. The University's list of renowned researchers includes Nobel Laureate in Medicine Arvid Carlsson (2000).
The University of Gothenburg is the first Swedish higher education institution to host scholars within the framework of the Scholars at Risk network. The scholars arrived in September and will spend one year in Gothenburg. The University of Gothenburg is also since March 2016 the coordinator of the Swedish Scholars at Risk network.
Read more about the University's work with Scholars at Risk
[5 Jul 2017] Anashid is a genre of music used by Lebanese Hezbollah and Palestinian Hamas to, among other things, stir emotions, send messages and create unity. Membership of these organisations is not a role that one can step into and out of, meaning that the same type of music is also prevalent in personal contexts and thus becomes a part of the individual¿s identity. These are the findings of a thesis from the University of Gothenburg.
[5 Jul 2017] Patients with speech and language disorders risk losing out on their right to have a say in their care. Research at Sahlgrenska Academy is now highlighting the need for uninterrupted communication with healthcare staff, clear strategies from the care provider¿s side and individual communication plans for elderly residents in long term care facilities.

subset: commoncrawl


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Best Of :: Shopping & Services
Nowadays, one man's trash is pretty much everyone else's treasure. But with retro, rustic, and recycled home décor on the rise, flea markets, swap meets, and Saturday morning garage sales simply aren't enough to satisfy the hungry junk fiend.
Lucky for us, professional pickers Lindsey Holt and Coley Arnold have banded together the best and the brightest treasure hunters in town to create the biannual Junk in the Trunk Vintage Market. This Scottsdale showcase of more than a hundred hand-selected vendors features everything from vintage collectibles to handcrafted custom creations. Save the dirty work for the dumpster divers because, thanks to Junk in the Trunk, one-of-a-kind finds aren't out of reach.
In just a year, Altitude Coffee Lab has become known for its roasts, but this cafe is more than that. The low-key interior is homey and relaxed, the perfect spot to spend an afternoon getting work done on the ivy-covered patio. Should you get hungry, Altitude offers full breakfast, lunch, and dinner menus that include dishes from all over Europe like Spanish frittata, Danish smørrebrod, and more. For aspiring musicians and poets, weekly open mic nights on the high-end shop sound system will present your work well. Should you need liquid courage before you perform, the coffee house also offers beer, wine, and a small selection of spirits. However, you shouldn't leave without trying the Gibraltar, which mixes espresso and foamed milk at temperatures lower than a cappuccino's so you can taste the amaretto and raisin notes of Altitude's espresso blend.
When we say Phoenix coffee, you say Cartel. Phoenix coffee, Cartel. Seriously, though, you might have your favorite spot to relax or get work done, but this is about the roast. All ambiance arguments aside, there's a reason that celebrities hit up the roaster when they're in town. With a strong focus on natural, unwashed beans and bright, acidic flavors, Cartel-roasted coffee is a unique experience, regardless of the bean you choose. You must be made of stone if can resist grabbing a cup after passing by the Tempe Cartel during roasting hours and smelling the intoxicating coffee aroma wafting from the building. Though you can buy the beans and take them home, feel free to let the highly trained barista staff show you how it's done if you're not a confident home brewer, and don't be afraid to ask questions.
In the morning, French Grocery makes a perfect coffee stop, complete with locally roasted espresso from Tempe's Cortez Coffee. And for more filling fare, there's the weekly menu of cuisine from chef and owner Kevin Lentz. He's spent most of his adult life living and eating in the Big Easy and wanted to bring some of that city's flavor to Phoenix. No matter the time of day, we can swing by for one of the restaurant's macarons, which come in an array of colors and flavors that change each week. And as if that's not enough, French Grocery provides a well-curated selection of wines, cheese, and other artisan products, including European-style butter, goat milk, and chocolates. We only wished we lived closer to French Grocery — or that this type of neighborhood market and restaurant will start taking off all over town.
Though we're happy to see farmers markets popping up in just about every Valley neighborhood, we have to admit our favorite Saturday morning stop is still the Old Town Farmers Market. Because as much as we want to eat local and healthy, we don't have the time — or energy — to make a dozen stops to get the shopping done. The variety of vendors at the Old Town Farmers Market makes this a one-stop shop for market-goers with everything from organic produce to grass-fed beef and local honey. And in most cases, you'll have your choice between several vendors in each category. It's true that things slow down during summer, but at least we can still get in and get the basics before the heat really hits. The fact that the market is dog-friendly is a big plus, because we feel guilty about taking our time when we leave our four-legged baby home alone.
When it comes to cocktail classes in Phoenix, Jade Bar has something for everybody. With a weekly rotating course focusing on gin, whiskey, rum, Prohibition-era cocktails, Tiki cocktails, and more, you certainly can pick your poison. Thirty dollars gets you about four cocktails per class, plus a wealth of information ranging from preparation to history. With small class sizes of 10 people, you get plenty of time for individual instruction and Q&A. Given that it's one of the bars that launched the careers of many of the Valley's top bartenders, you're sure to get an education worthy of any pro. Be warned, though, you may want to consider a room at Sanctuary after the class because those cocktails can knock you on your bum.


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Refresh your bedroom interior with elegance and style with this contemporary Bedroom Set from Alba Collection by At Home USA. The bed features headboard with curved edges and tufted beige upholstery. Dresser and 2 Nightstands offer storage space for all your bedroom accessories. Dresser comes with matching mirror. The bed is available in Queen and King sizes. Optional Bench and Closets can be added to complete the set. Bench is designed in contemporary style with slightly curved legs finished in glossy dark, and beige upholstery. Closet offers an additional space for storing your clothes and comes in two types: Dresser Mirror with Door Swivel Dresser Mirror.
The set includes Queen size Bed, Two Nightstands, Dresser and Mirror.
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- Contemporary 5 PC Bedroom Set
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- Optional Bench and Closets
- Queen Bed: 89 x 71 x 46.5
- King Bed: 89 x 83 x 46.5
- Nightstand: 23.5 x 17.5 x 19
- Dresser: 66 x 20 x 31.5
- Mirror: 35 x 47
- OptioBench: 59 x 18 x 16.5
- OptioCloset (Dresser Mirror with Door):18.5 x 19 x 71
- OptioSwivel Closet (Swivel Dresser Mirror):16 x 16 x 69
Contemporary furniture wholesaler has started its work in 2005 and continues to grow now. We provide the contemporary furniture from across the world and offer superior customer service.
At Home USA furniture line that ranges from super comfortable and sleek bedroom pieces, sofa sleepers, leisure chairs and much more are always priced right. We are glad to bring comfort and coziness to your home decor!
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12 Card 06 Bowman Sterling Jeremy Jeffress Auto RC Lot
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Natural History
- Source: eBay
- Sold Date: Aug 13, 2008
- Channel: Auction House
You are bidding on a (12) twelve card lot of 2006 Bowman Sterling Jeremy Jeffress Autographed RC Cards. This is the kid with the 100 MPH fastball and this is his only autographed RC card. You will receive all 12 of the cards in the picture. Please email me with any questions and thank you for bidding. Check out my other items for some great top prospect cards.


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Ratings: IMDB: 6.8/10 Metascore: N/A RT: 86%
Released: October 21, 2014
Runtime: 110 mins
Genres: Biography Documentary Music
Actors: Gary Kemp Steve Norman Tony Hadley
Soul Boys of the Western World: Set against the backdrop of the 80's music scene, this documentary charts the meteoric rise, fall and ultimate reunion of pop sensation,
Spandau Ballett told by the band members themselves with unseen archive footage that will thrill the many fans and beyond.
Soul Boys of the Western World ( 2014 )
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There are currently 13 users online. 8 members and 5 guests
Most users ever online was 174, 13-09-2011 at 22:46.
Welcome mark. The next intro ride is this Sunday but that's probably a bit soon so look out for the august one.
Welcome dude, sound like majority of us
Welcome mark, from the title sounds like you'll fit right in
Hi Folks,
I'm Mark and just got myself some wheels again after being without for about 4 years because of health issues.
Will be spending
I'm currently looking at the new Golf GTE Hybrid...
will have to fold rear seats to get bike in, but i do that now with my honda estate
Cheers guys.
I'll be working between altrincham and the airport, so taking the train from widnes is almost impossible.
I've found the perfect
hi d j. I'm the same boat. i own an old saab just need to drop the front wheel.
just come with your bike in bits as I do. I'll bring along another
Hi ste not fully back neck n shoulder still very sore and painful when i move it in certain postions but getting there
Nice one [MENTION=3118]mikep[/MENTION]. Have you recovered from Tuesday nights episode?
Hi ste parts have come so all ok for this now


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Intercept Pharmaceuticals, Inc., (NASDAQ:ICPT) is a biopharmaceuticals company, based in New York City, New York, focusing on "the development and commercialization of novel therapeutics to treat orphan and more prevalent liver and intestinal diseases by utilizing its expertise in bile chemistry." During trading sessions last week, the PPS of Intercept climbed nearly 500% to its nadir due to the positive news centering the early stoppage of the Flint trial. The decision to prematurely cease the trial stemmed from Intercept's lead drug, obeticholic acid ("OCA"), superiorly met its primary outcome needed for the treatment of non-alcoholic steatohepatitis ("NASH"). Since their ascension, ICPT shares traded 40% to 50% discount to their 52-weeks high due to the subsequent press release regarding the unfavorable lipid profiles found in patients who received OCA treatment in the Flint trial.
Source: StockCharts
I usually do not analyze companies that recently went public, thus I would have overlooked Intercept for the company IPOed no longer than a year ago. The statement "to every rule, there's an exception" is indeed true, for Intercept is the sole exception to my investing rule that I uncovered during the past seven years. Hence, I am going to present to readers my analysis of this excellent investing opportunity from an "integrated investing" approach of a young medical doctor, a researcher and an investor.
Investment Thesis
According to Warren Buffett's mentor, Benjamin Graham, Mr. market tends to behave in either extreme, by quoting a stock either too high or too low. This pendulous swing in the share prices of many issues creates an excellent opportunity for the intelligent and enterprising investors, who are willing to conduct additional research. Based on my due diligence, I would not recommend readers to purchase Intercept when the company's shares were trading in the proximity of $497. However, recent pessimism pushed the PPS of this great company down to its low of $247, which created a wide "margin-of-safety". As a result, this transformed ICPT into a bargain issue … one holding potential blockbusters. In Peter Lynch's world-renowned lines, I believed that this is "an investment that I would recommend to my mother-in-law."
The Pathophysiology of Non-Alcoholic Steatohepatitis ("NASH")
Before I would proceed further, it is important for readers to have a background understanding of NASH. The physician executives at Intercept described it best …
NASH is a serious chronic liver disease caused by excessive fat accumulation in the liver that, for reasons that are still incompletely understood, induces chronic inflammation which leads to progressive fibrosis (scarring) that can lead to cirrhosis, eventual liver failure and death. There are currently no drugs approved for the treatment of NASH. Studies have shown that over a ten year period at least 10% of NASH patients will develop cirrhosis, and liver-related mortality due to this disease is ten-fold that mortality of the general population. According to recent epidemiological studies, it is estimated that approximately 12% of the U.S. adult population has NASH, while 2.7% (potentially more than six million patients) are believed to have advanced liver fibrosis or cirrhosis due to progression of the disease. The proportion of liver transplants attributable to NASH has increased rapidly in past years and over the next decade the disease is projected to become the leading indication for liver transplant ahead of chronic hepatitis C and alcoholic liver disease.
The Mechanism of Actions of OCA Explained The Drug's High Efficacy And Potency In Treating NASH
Obeticholic acid ("OCA"), an FXR agonist/bile acid analogue, works by stimulating one of the two "holy grail receptors", namely, the farnesoid X receptor ("FXR"). By activating FXR, OCA induces a plethora of the following regenerative responses innate in the liver: the maintenance of bile homeostasis, reversal of fibrosis and stimulation of fibrosis repair, reduction of inflammation and portal pressure, improvement of insulin sensitivity, as well as, the reduction of lipid synthesis and reduction of hepatic toxicity.
Source: Intercept Pharmaceuticals
In contrast to the natural bile acid (chenodeoxycholic acid or CDCA), it's important to note that OCA is 100x more potent than CDCA due to the presence of an added ethyl group at the 6-C position in OCA.
Source: Intercept Pharmaceutical
The Flint Trial's Early Stoppage Is Highly Indicative of OCA Efficacy, Safety, And Potency
OCA is currently in its Phase II of development. On January 9th, 2014, the Flint trial was stopped early due to the interim data evidencing that OCA produced highly statistically significant results in meeting its primary end points: (1) preventing the progression of fibrosis and (2) reducing the NAFLD Activity Score ("NAS") by at least two points.
NEW YORK, Jan. 9, 2014 (GLOBE NEWSWIRE) -- Intercept Pharmaceuticals, Inc. today announced that the Flint trial of obeticholic acid for the treatment of nonalcoholic steatohepatitis has been stopped early for efficacy based on a planned interim analysis showing that the primary endpoint of the trial has been met. Flint is a multi-center, double-blind, placebo-controlled clinical trial assessing the safety and efficacy of a 25 mg oral dose of OCA administered daily to biopsy-proven adult NASH patients over a 72-week treatment period. The trial has been sponsored and conducted by the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), a part of the National Institutes of Health, at eight leading US academic hepatology centers comprising the NIDDK's NASH clinical research network.
The decision to stop FLINT has been based on the recommendation of the Data Safety Monitoring Board, which reviewed liver biopsy data from before and at the end of the treatment period in approximately half of the 283 randomized patients, in accordance with a planned interim efficacy analysis. This analysis demonstrated that OCA treatment resulted in a highly statistically significant improvement (p=0.0024 on an intention-to-treat basis) in the primary histological endpoint, defined as a decrease in the NAFLD Activity Score of at least two points with no worsening of fibrosis, as compared to placebo. Those patients who had not yet completed the trial and therefore did not have a second biopsy were treated as non-responders in the ITT analysis. The pre-defined threshold of statistical significance for stopping Flint was p < 0.0031.
While it is anyone's guess regarding the specificity in the discussions amongst the members of the Data Safety Monitory Board ("DSMB"), I strongly believed that the DSMB stopped the trial because the interim data indicated that OCA worked quit well and it is indeed safe. Otherwise, why did the DSMB made such an important/consequential decision without supporting evidence?
An Integrated Approach Shed Light Into The "Alternative Hypothesis" Suggesting That The Changes In Lipid Profiles of Patients Taking OCA Is Inconsequential
It is understandable that most investors would panic when they heard the news that OCA might be associated with an increased in LDL cholesterol and a reduction in the HDL cholesterol … for even medical experts and physicians were trained to reflexively associate such changes in cholesterol with corresponding increased in cardiovascular risks. I confessed that I am guilty was well. Nevertheless, my training in integrated investing taught me to re-examine the established beliefs. Being a maverick, I am not ashamed by the very fact that nearly all of my students far exceeded me in the very skills that I taught them. Hence, I asked my better half, TP, whom I have mentored for the past four years, to help me to "connect the dots" as to why OCA might cause a rise in cholesterol … despite its outstanding regenerative effects on the liver. Based on what I learned from TP and what I learned from my own "gedanken" experiments, I proposed an "alternative hypothesis" - indicating that the increased cardiovascular risk associated with changes in cholesterol found in patients taking OCA is highly unlikely to materialize into cardiovascular pathology per se.
The Therapeutic And Anti-Inflammatory Effects of OCA Negate Potential Risks Associated With Unfavorable Lipid Profiles
In my "thoughts experiment", I closed my eyes and visualized various molecules working in dynamic reaction equilibriums. Accordingly, natural bile acid was visualized as one of the end products in a series of reactions … with this end product emulsifies/transports the fats that we eat across the intestine into the hepatobiliary circulation. Based on the principle of negative feedback inhibition, when bile acid builds up it would bind to FXR (its regulator upstream) transducing FXR an inhibitory signal to stop synthesizing excess bile acids. Since bile acids are synthesized from cholesterol, suppressing the synthesis of bile acids via the action of OCA (an enhanced synthetic bile acid) would result in an increase in total cholesterol. In other words, when OCA activates FXR, less cholesterol would be consumed in order to synthesize natural bile acids. This resulted in more cholesterol available in circulation, which showed up as higher level of total cholesterol and LDL cholesterol observed in the Flint trial. Though the exact etiology for NASH is unknown, I believed that inflammation rather than the buildup of fats alone is the culprit. Given the fact that OCA suppresses inflammation, this explained how OCA exhibited such highly statistical significant in treating NASH. Moreover, the therapeutic effects of suppressing inflammation by activating FXR would negate any potential negative effects of changes in lipids profile.
Inflammation Is More Important Than The Changes In Cholesterol In Being The Culprit That "Actually Materializes" Cardiovascular Risks Into Cardiovascular Pathology
In an analogous line of reasoning, I believe that atherosclerosis, the process of plaques building up in arteries, directly resulted from the inflammation rather the elevation of total cholesterol per se. An atherosclerotic plaque would be unlikely to form in a patient with high LDL and high total cholesterol while having a normal blood pressure and normal level of HDL cholesterol. Conversely, when the same patient has high blood pressure (hypertension) and low HDL cholesterol, their arterial wall would be more likely to be damaged from the increased pressure links to hypertension. In the presence of this damaging effect from hypertension, inflammation is much likely to kick-in to form plaques. So how does this relate to my premise that the elevation of total cholesterol/LDL cholesterol associated with OCA treatment is a minor issue?
Since OCA suppresses inflammation in the liver and I believe that this anti-inflammatory effect occurs in the arteries as well. Hence, the negative effects like plaque formation and cardiovascular pathology linked to the inflammatory process would be abated.
Statins And Omega-3 Fatty Acids Are Efficacious, Safe, And Cost-Effective Solutions To The Problem of Unfavorable Cholesterols
Let's assume that my alternative hypothesis, based on the fundamental principles of medicine and biochemistry, is invalid; my argument stating that the suggested unfavorable lipid profiles found in the interim data might be a minor issue … is still valid! For instance, the elevation in LDL cholesterol and the reduction in HDL cholesterol are obstacles that could be overcome by starting patients on a statin (for instance, Lipitor) and omega-3 fatty acids, respectively. Lipitor, a statin with an immaculate history of safety and efficacy, lowers the LDL cholesterol/total cholesterol by inhibiting the rate-limiting enzyme (HMG Co-A Reductase) involved in cholesterol synthesis. The fact that Lipitor is available as a generic drug made it the clinically effective, as well as, cost-effective solutions to the changes in blood cholesterols. In addition, the potentially lowered HDL cholesterol or good cholesterol associated with taking OCA could always be alleviated by prescribing patients with omega-3 fatty acids available over-the-counter. An alternative solution would be to recommend patients to consume healthy and delicious food like salmon, if they could afford it.
Potential Counter Arguments
While the odds of are favorable that Intercept is a prudent investment for the intelligent/enterprising investors, the drugs is still needed to be FDA approved and the approval process could be a "crap shoot" at times. Consequently, a negative FDA approval could send the stock's PPS into free-fall. However, a nod from the Agency could result in significant short terms profits. Based on my experience of studying hundreds of drugs that received approval and based on the reasons mentioned … I strongly believed that the odds are overwhelmingly in the favor for OCA's approval. The case for OCA's approval is case of "when" rather than "if" the FDA would approve the drug. Furthermore, OCA is currently being study for its indications to treat other pathology. This is not to mention the other drugs in Intercept's pipeline. Therefore, should OCA failed to gain the Agency's approval for treating NASH, the drug could still be used to treat other indications. Similarly, should OCA failed to gain the agency's approval to treat any disease, the company still has its other drugs in the pipeline. Hence, the margin-of-safety is indeed wide even from a pipeline perspective.
Favorable Chances That The Agency Would Approve OCA
I find it perplexing to believe that the FDA would deny patients of an efficacious medicine to treat NASH … a potentially lethal disease that does not have any effective and safe pharmacotherapeutic treatment available. Given that 10% of patients with NASH would develop the irreversible and fatal disease (hepatic fibrosis) without OCA, I believe that the FDA would be highly motivated to approve this drug. Otherwise, the FDA would have a difficult time trying to explain their rationale to legions of activist groups, who would publicly scrutinize (to the minute details) the Agency's interest, as well as, the interests of the experts working for Agency. It was not long ago that the Agency's rogue scientist who committed fraud marred the FDA's public image. I highly doubted that the Agency would want to risk another reputation-damaging press event.
The Excellent Benefits-To-Risks Profile Necessitates Clinicians To Prescribe OCA Once The Drug Would Gain FDA Approval
I strongly believed that physicians would prescribe OCA "en mass" after it gained the Agency's approval … for the simple yet important reason that this drug has a favorable benefits-to-risks profile. As an MD, I can attest to this well-known fact. Though I might be a young and inexperienced MD, I was taught by some of the best physicians and researchers in medicine and human nutrition. What I learned was that the key whether to prescribe a drug is its "benefits-to-risks" profile, as well as, whether the evidence-based medical guidelines support the drug as the standard of care. The evidence clearly demonstrated that there's no pharmacotherapy to treat NASH, once it is left to progress to hepatic fibrosis. The main risk of treating patient with OCA is an unfavorable lipid profile yet this drug could save patients from losing their liver, thus saving their lives. This fact alone substantiated a favorable benefits-to-risks necessitating and validating OCA' s much-needed therapeutic roles. In reference to the unfavorable lipid profile associated with taking OCA, it is not something that cannot be remedied as I previously elucidated.
Intercept's Unique Management Consisting of Nearly All MDs, And They Went "All-In"
I am not sure whether the management of Intercept has been asking similar questions like I have; however, they went "all in" by holding 42% of the shares outstanding in the company. This management is rare for all of their members are MDs (with the exception of one JD). It is not difficult to imagine that the physicians, running a company that they have a huge ownership stakes, would surely know the true prospects of their drug candidates.
It is understandable that some investors, myself included, would initially worry about recent insider sales. This prompted me to investigate deeper into ICPT insider transactions. Accordingly, I went through recent SEC filings and I uncovered that those transactions were initiated through the company 10b501 on December 19th 2013 ... when the PPS were trading in the $60 range! This important fact proved that the insiders did not sell because they saw something negative in OCA. Had they saw some impending doom in OCA, they would have sold whole lot more than the aggregate values of less than $6millions out of their 42% ownerships stake in a nearly $6 billion dollars company.
Concluding Remarks
Before you decide to invest in Intercept, you should ask yourself whether ICPT's management would know more about the company that they run than Wall Street? Whether they would know about the chance of the Agency's approval for their drugs? Whether their drugs would generate blockbuster sales? After all, physicians are the ones responsible for prescribing drugs. Moreover, many physicians conduct clinical research; some physicians publish extensively, and some physicians even chair the very committee that votes to approve the drug.
As a final note, I have nothing personal against short-sellers and I strongly believed that certain companies should be shorted. In fraud and overvalued situations, shorting induces a safe environment for investors. Moreover, when shorting stocks the short sellers, who have excellent records of accuracy must run that extra mile to gain the edge in being dead accurate. I highly respect the prophetic short sellers like Andrew Left of Citron Research or Bill Ackman of Pershing Squares. However, ICPT is a situation that would burn any one trying to short this rare stock. In my research, I uncovered a well-known short seller, which I will not name, actually went long on ICPT at its current price.
Good Luck Investing!
Disclaimer: I am an MD, researcher, writer, and a patient activist. Currently, I no longer do clinical work. However, I have access to physician colleagues who I go to for additional insights. Since I am no longer working under any medical licensing authorities or affiliated with any programs or working for any hedge fund, I have the freedom of being able to write without any constraint. The companies that I featured are those that I researched thoroughly to the best of my ability. I often found myself spending days or weeks researching a company only to discard my research when nearing its completion, because I uncovered new data that do not support my thesis. Though I strive to provide the most accurate information in my research, the nature of information changes over time. Therefore, I reserved the right to change my holding without notification. I am not a registered financial advisor. I am not making any recommendation to purchase or dispose any securities. You should use the information provided by my research as a starting point to conduct your own due diligence. The nature of risks tolerance differs for different individuals. Hence, you should consult your investment advisor before investing in security. On a final note, please send me an email if you find that I miss certain information. You have my open ears.
Disclosure: I am long ICPT. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it. I have no business relationship with any company whose stock is mentioned in this article.


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+91-11-45679615Post Your Requirement
Description :
There will be a Meet & Greet reception on arrival at NJP / IXB followed by a transfer to Darjeeling, one of the most magnificent Hill Resorts in the World. On arrival, check-in to the hotel & spend rest of the day in leisure. Overnight stay will be at Darjeeling.
Description :
Early morning 04:00 am: Drive to Tiger hill to watch the spectacular sunrise over Mt. Kanchenjunga (situated at 28,208 ft. above sea level it's the world's third highest peak). On your way back, visit Ghoom Monastery and Batasia Loop. After breakfast, visit Himalayan Mountaineering Institute, P.N. Zoological Park (closed on Thursday) Tenzing Rock, Tibetan Refugee self-help Centre (closed on Sunday), Tea Garden (outer view), and Japanese Temple. Evening is free for you. (Walking tour of the mall - suggested). Overnight stay will be at Darjeeling.
Description :
After breakfast, go for an excursion trip to Mirik Lake an excellent scenic spot, nestled in forested hills at an altitude of 5800 ft. and famous for its man-made Sumendu Lake, Orange Orchards, Cardamom plantations and Tea Estates enhancing the surroundings here. Evening: Return to the hotel. Overnight stay will be at Darjeeling.
Description :
Morning free for packing & personal activities. Check out of the hotel and take the departure transfer to NJP railway station / IXB airport for your onward journey.
Mr. Abdullah Ahmed


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"They Strike My Wings with Sticks" on Hyphen!
So incredibly pleased to see my story They Strike My Wings with Sticks on Hyphen Magazine! Working with Karissa Chen was a revelation. It's also amazing to see original illustrations for it — love seeing new art based on something I've made!


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Spennymoor's newest pub has hired a General Manager after a national search and installed her ready for launch in August.
We're delighted to announce that Lorraine Smith has become the first member of staff at The Moors Tavern, which is in the midst of a full refurbishment ahead of relaunch next month.
The pub, formerly known as The Salvin Arms, was recently bought by Red Oak Taverns and will be rented by the club for at least the next five years. After a three-week search, we hired experienced General Manager Lorraine Smith, who will now set about hiring her team of staff from the area.
Smith has a rich pedigree in the hospitality sector, having worked for Whitbread, Marriott and a number of independently run Hotels, the most recent of which was managing a luxury hotel in York city centre.
Originally from the North East, she has worked across the country, before moving back to take on this latest challenge.
She said: "I was seeking an opportunity that had community at its heart. The club has a loyal following and I am really excited to be opening The Moors Tavern, which will be stunning once the refurbishment is complete."
Smith's 15 years of experience in the sector means she knows what she's looking for when it comes to her team of staff.
"I'm passionate about giving local people opportunities," she said, "we're a community pub so we want to create jobs for those in our community. I'm looking for people with talent and enthusiasm to join the team.
"Just as the football club is a focal point, we hope this pub will become one too. We'll be open seven days a week, so it's not just Spennymoor Town's pub."
Bradley Groves, Chief Executive of Spennymoor Town FC, said: "Lorraine stood out as a quality candidate to take over at the helm of The Moors Tavern. We received many applications but her experience speaks for itself and her manner and personality are just what we'll need to make it a success.
"The pub will make an attractive addition to match days at The Brewery Field and we hope people in Spennymoor get behind it. I'd like to wish Lorraine the very best of luck."
Further details about the launch date will be circulated in coming weeks.
The Tyne Crescent gate into Spennymoor Town's stadium, The Brewery Field, will be reopened in conjunction with the pub, allowing fans attending on a match day a short walk from the pub to the ground.
For further information and updates on The Moors Tavern, visit www.spennymoortownfc.com or follow the pub's newly created Twitter page @moorstavern.
If you're interested in working at The Moors Tavern with Lorraine, click here to view the vacancies.


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Husband Noticed Mysterious Black Spots On Wife's Hand, What Happened Next Is Simply Haunting!
The count of different kinds of rare diseases is increasing so frequently that now it's leaving many terrified, shocked and loathed while some are becoming the sympathized sufferers. Some of the diseases are so rare that the unlucky person who becomes victim to that disease gets his story famed all over.
Here is the story of a couple who faced some very rare diseases that changed their life's brighter days into dark days.


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Regular price: $896.47
Sale price: $664.05
Estimated Shipping Cost: $18.95
Add item to cart to check stock levels.
The Elkay Lustertone Undermount 31-9/16" x 21-1/8" Double Bowl Kitchen Sink with reveal features a unique double basin design, utilizing a prep sink along the right side of a larger sink for regular kitchen work. The twin basin construction affords optimal space to prep, clean or handle dishes and food with ease.


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Elastomers Fibers Thermoplastics
Classification based upon molecular forces
Depending upon the intermolecular forces, the polymers have been classified into four type.
(i) Elastomers (ii) Fibers
(iii) Thermoplastics (iv) Thermosetting polymers
(i) Elastomers : The polymers that have elastic character like rubber (a material that can return to its original shape after stretching is said to be elastic) are called elastomers. In elastomers the polymers chains are held together by weak intermolecular forces. Because of the presence of weak forces, the polymers can be easily stretched by applying small stress and regains their original shape when the stress is removed. The most important example of elastomers is natural rubber.
(ii) Fibers : These are the polymers which have strong intermolecular forces between the chain. These forces are either hydrogen bonds or dipole-dipole interaction. Because of strong forces, the chains are closely packed giving them high tensil strength and less elasticity. Therefore, these polymers have sharp melting points. These polymers are long, thin and thread like and can be woven in fabric. Therefore, these are used for making fibers.
Example: Nylon 66, dacron, silk etc.
(iii) Thermoplastics : These are the polymers which can be easily softened repeatedly when heated and hardened when cooled with little change in their properties. The intermolecular forces in these polymers are intermediate between those of elastomers and fibres. There is no cross linking between the chain. The softening occurs as the polymer chain move more and more freely because of absence of cross link. When heated, they melt and form a fluid which can be moulded into any desired shapes and then cooled to get the desired product.
Example : Polythene, polystyrene, PVC, teflon etc.
(iv) Thermosetting polymers : These are the polymers which undergo permanent change on heating. They become hard and infusible on heating. They are generally prepared from low molecular mass semifluid substances. When heated they get highly cross linked to form hard infusible and insoluble products. The cross links hold the molecule in place so that heating does not allow them to move freely. Therefore a thermosetting plastic is cross linked and is permanently rigid.
Example : Bakelite, melamine formaldehyde resin etc.
Example 1: Thermoplastics are
(a) Linear polymers (b) Highly cross-linked
(c) Both (a) and (b) (d) Crystalline
Ans: c
Email Based Homework Assignment Help in Polymers Classification based upon Molecular Forces
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There are around 80 Habitat for Humanity homes in the Granbury area, and a large number were in the path of Wednesday night's tornado. Workers at Longview's Habitat for Humanity are playing a waiting game, trying to find out if people they helped and their own workers in that area were affected in the tornado. They're also waiting to see how they can help
"We got official word this morning through our state affiliate, that 61 homes in the Rancho Brazos neighborhood were Habitat homes. We have not gotten official word on the amount of damage, or injuries or loss of life," says Longview Habitat executive director LuJaun Hollis.
Their own Hood County Habitat branch was hit very hard.
"They also suffered damages, they lost all their tools and trailer," Hollis says.
Making calls and constantly checking web sites and emails, they still remained unsure of damage or any injuries to those they know.
"We don't know how to help yet because we don't have a team on the ground to tell us what's happened. It's just devastating for everybody involved," says operations manager Donna Shupe.
But they're prepared to do whatever is needed to help those affected.
"Our thoughts and prayers are with everyone that suffered in this tragedy last night. We have a team, a disaster relief team, from the Habitat International office en route. We've got help on the way; we'll be right behind them," Hollis says.
If you would like to assist Habitat for Humanity's efforts to help the tornado victims, we've set up a link for you on kltv.com.
Copyright 2013 KLTV. All rights reserved.


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John Harwood is Editor at Large for CNBC covering Washington and hosts the CNBC Digital original video series "Speakeasy with John Harwood."
Harwood was born in Louisville, Ky., and grew up in the Maryland suburbs outside of the nation's capital. He has been around journalism and politics all his life; his first trip on a presidential campaign press plane came when he was 11 years old and accompanied his father, then a political reporter for The Washington Post.
While still in high school, he began his journalism career as a copy boy at The Washington Star. He studied history and economics at Duke University and graduated magna cum laude in 1978. Harwood subsequently joined The St. Petersburg Times, reporting on police, investigative projects, local government and politics. Later he became state capital correspondent in Tallahassee, Washington correspondent and political editor. While covering national politics, he also traveled extensively to South Africa, where he covered deepening unrest against the apartheid regime.
In 1989, Harwood was named a Nieman Fellow at Harvard University, where he spent the 1989-90 academic year. In 1991, he joined The Wall Street Journal as White House correspondent, covering the administration of George H. W. Bush. Later Harwood reported on Congress. In 1997, he became The Wall Street Journal's political editor and chief political correspondent.
While at The Wall Street Journal, Harwood wrote the newspaper's political column, "Washington Wire," and oversaw the Wall Street Journal/NBC News poll. In March 2006, he joined CNBC as Chief Washington Correspondent.
In addition to CNBC, Harwood offers political analysis on NBC and NPR, among others. Harwood has covered each of the last nine presidential elections.
Follow John Harwood on Twitter @johnjharwood.
Some people have to realize that government requires compromise, says CNBC's John Harwood. John Boehner will probably remain speaker for awhile longer, he adds.
Democratic presidential candidate Hillary Clinton has come out against the Trans Pacific Partnership agreement, reports CNBC's John Harwood.
CNBC's John Harwood talks to Republican presidential candidates John Kasich, Jeb Bush and Chris Christie about their position on Medicaid.
As a joint federal-state program serving the poor, Medicaid stands on narrower, shakier ground. That's especially true in the GOP presidential race.
CNBC's John Harwood reports on the tax reform proposals coming from Republican presidential candidates.
As they search for a presidential candidate, Republican voters face a choice on taxes: Reform the existing system, or start a new one?
CNBC's John Harwood spoke to presidential candidate Donald Trump about New York City real estate.
CNBC's John Harwood sits down with Republican candidate Donald Trump to talks about the core issues of his campaign.
Donald Trump talks to CNBC's John Harwood about truthfulness, policy questions, and if and when he might exit the race.
Donald Trump sits down CNBC's John Harwood to assess his campaign and address if and when he would exit the race.
Get the best of CNBC in your inbox


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Is SW supposed to update and reflect changes in AD in it's People module? Example, a users email address changes but their entry in "People" doesn't update! I can't change their email address in People as it just sits their saying "Saving". I'm guessing this is because the user has logged a ticket under their old email address and so there is also an entry for that very same person in "People"; how can I merge the two!?
This topic was created during version 5.1.
The latest version is 7.5.00101.
8 Replies
Aug 1, 2011 at 7:01 UTC
No way to merge as of yet,
here is a feature request for just that, you can help by spicing it up.
Your best bet would be to delete both, and then let AD run it's scan.
Aug 1, 2011 at 7:15 UTC
Cheers Jay!
I've been using SQL Database Browser up until now, but the latest version of SW doesn't seem to support this.
SQL manager in Firefox seems to do the job, but it's not as simple as SQL Database Browser and also with the new SW 5 all the records are locked so you have to close SW, fiddle the data, and then re-open!
Aug 1, 2011 at 7:18 UTC
Sorry - also, how do I delete "People"?!
I can only set them to inactve!
Aug 1, 2011 at 7:21 UTC
Click the person you want in inventory view, then in their details pane, right side, click "Edit" you should then see an option for "Remove".
Aug 1, 2011 at 7:27 UTC
Doesn't that just put them to "inactive"???
Aug 1, 2011 at 7:34 UTC
5th paragraph down,
So yes this will move them to inactive, to permanently remove them you would need to remove them from the database. I believe SW does the inactive for ticket purposes and what not. Removing them completely could corrupt any ticket the had created.
Aug 1, 2011 at 7:39 UTC
Aye - no worries; seems will just have to continue to "fudge" inaccurate data with SQL tools.
Understand why SW would need to retain old data, but what would be better would be to, once a ticket has gone beyond the point of being able to be re-opened, run an overnight process that updates the tickets table with acutal data rather than id's linking to the users table. This way you can maintain the integrity of the data without holding on to old users!
Oh well, back to the SQL Manager!
Aug 1, 2011 at 7:44 UTC
Good luck Dave, and if you run into any problems just give a yell.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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Hotel was fine but front desk manager had bad English and asked a lot of questions. We asked to be put on the same floor, rooms beside each other. On the same floor but not near one another. Never made it to breakfast. Hotel nicely...More
Getting you more information on this room
Getting you more information on this room
"I like to stay at the end of hall to make it easier to get the dog in and out. No exception in this hotel..."


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Any idea on the best thing to use to make Aerial from the Little mermaid out of? Fondant, gumpaste, chocolate modeling clay??? Any ideas on how to make a mermaid??? I have to make on for this weekend and I have no qlue where to start!
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Neighbourhood countries
Justice cooperation is a crucial component of European Neighbourhood Policy Action Plans.
The EU offers its neighbours a privileged relationship, building upon common values - democracy and human rights, rule of law, good governance, market economy principles and sustainable development. Developed in 2004, the European Neighbourhood Policy (ENP) aims to strengthen the prosperity, stability and security of countries in the region while avoiding the emergence of dividing lines between the enlarged EU and its new neighbours.
Recognising the potential of the ENP as an arena for cooperation with countries sharing EU borders, the Strategy for the External Dimension of Justice, Freedom and Security of 2005 identified the policy as a priority. This is why the action plans with individual countries have significant justice components.
Significant investments to enhance the capacity and efficiency of the judiciary were made. To strengthen regional cooperation in the field of justice, training schemes for judges, prosecutors, lawyers and senior police officers from partner countries have been put into practice.


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32 Lakeridge Dr Toronto, Ontario M1C5C2
Hi, ANNIE KARADJIAN.
My name is
and I have a question about 32 Lakeridge Dr Toronto
You can respond by either emailing me at
or call during
My Question Is:
Estimated Monthly Payment$5,051
- Photos
- Location
- Questions
- Share
- Mortgage Calculator
- Status: Active
Listing courtesy of RE/MAX ALL-STARS REALTY INC., BROKERAGE
Beautiful Lake Views From This 3 Bedroom End Unit Townhome, Feels Like A Semi, Features Include New Oak Floors, Led Pot Lights, Quartz Counters & More, Living Room Walk Out To A Two Tier Deck And Gazebo, Steps To Schools, Go Transit, T.T.C, And A 5 Minute Walk To Waterfront Trails, Beautifully Finished Basement For Extra Living Space, Must Be Seen!, Extras Fridge, Stove, Dishwasher, Washer, Dryer, Central Vac. 10 X 10 Gazebo, Directions Port Union/Lawrence
Interior Features Include:
Air Cond: Central Air
Heating: Forced Air
Exterior Features Include:
Acreage: 0.0000 Acres
Exterior: Brick
Garage/Parking: Built-In
Drive Private
Parking Spaces 2
Parking Included Y
Other Features Include:
Community: Centennial Scarborough
Furnished Y/N N
Water: Municipal
Sewer: Sewers
Pool: None
Private Entrance Y/N Y
Total Rooms 7
Information provided by Toronto Real Estate Board, and is deemed reliable but not guaranteed accurate.


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Today, Senator Joe Donnelly announced a federal grant awarded by the Federal Aviation Administration (FAA) that will allow the Evansville Regional Airport to complete its runway rehabilitation project.
Under the FAA's Airport Improvement Program, Evansville Regional Airport was awarded approximately $13.7 million. With this grant, airport officials estimate that the current project is expected to finish a full year ahead of its December 2015 target date.
Donnelly said, "Hoosier families and businesses rely on our state's efficient infrastructure to get from one place to the next or to move goods and services. This grant provided by the Federal Aviation Administration will allow the Evansville Regional Airport to improve its runway so that passengers continue to be safe traveling in and out of Indiana."
Douglas Joest, Airport Manager of the Evansville-Vanderburgh Airport Authority District, said, "We look forward to receiving this additional grant for the Runway Safety Area Project here at Evansville Regional Airport. We greatly appreciate Senator Donnelly's efforts in keeping this project on track, especially given the challenging budget environment. This latest grant will enable us to finish the project more than a year before the deadline of December 31, 2015."
Source: http://www.donnelly.senate.gov/newsroom/press/donnelly-announces-grant-to-improve-runway-at-evansville-regional-airport


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- 08027
- Gibbstown, Nj (Miscellaneous » ZIP Codes)
Abbreviations dictionary. 2012.
Abbreviations dictionary. 2012.
Free Methodist Church (Dayton, Oregon) — U.S. National Register of Historic Places … Wikipedia
Religion abrahamique — La caravane d Abraham, par James Tissot vers 1900. Jewish Museum, New York. L expression religion abrahamique désigne principalement le judaïsme, le christianisme et l islam dont les écritures, c est à dire la Bible et le Coran … Wikipédia en Français
Communes of the Ardennes department — The following is a list of the 463 communes of the Ardennes département in France. INSEE Postal Commune 0800 … Wikipedia
Gibbstown, New Jersey — Infobox Settlement official name = Gibbstown, New Jersey settlement type = CDP nickname = motto = imagesize = image caption = image mapsize = 250x200px map caption = Map of Gibbstown CDP in Gloucester County mapsize1 = map caption1 = subdivision… … Wikipedia
Greenwich Township, Gloucester County, New Jersey — for other New Jersey townships with the same name see Greenwich Township, New Jersey Infobox Settlement official name = Greenwich Township, New Jersey settlement type = Township nickname = motto = imagesize = image caption = image mapsize =… … Wikipedia
Area codes in Germany — see also Telephone numbering in Germany for further codes including service numbers, cell phones etc. Area codes in Germany (German Vorwahl ) have two to five digits, not counting the leading zero. The leading zero must be dialed when calling… … Wikipedia
Dietramszell — Dietramszell … Wikipedia
USS Newport (PF-27) — USS Newport (PF 27), a Tacoma class frigate, was the second ship of the United States Navy to be named for the city of Newport, Rhode Island.The second Newport (PF–27) was laid down by Walter Butler Shipbuilding Company, in Superior, Wisconsin,… … Wikipedia
Orgosolo — Comune Comune di Orgosolo … Wikipedia
Employment discrimination law in the United Kingdom — combats prejudice in the workplace. It protects discrimination against people based on gender, race, religion or belief, sexuality, disability and, most recently, age. There are also important provisions which deal with discrimination by an… … Wikipedia


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Automatic Sunshine (Mary Wilson)
Limited Edition Print
Supremes backing singer Mary Wilson only got to sing lead vocals on one single – the exquisite Automatically Sunshine. Just a fragment of that sweet song or a glimpse of her beautiful face will bring Automatic Sunshine into your life, every time…
It's a high quality limited edition giclee print, using UltraChrome pigment inks on acid free Hahnemühle 310 gsm William Turner watercolour paper.
Limited Edition Print
Small (500mm x 610mm) edition of 250.
Large (800mm x 960mm) edition of 100
Each design is released in a strictly limited edition, signed and numbered, with a certificate of authenticity.
Soul Stars Series
The SoulStars prints are based on a series of original paintings combining likenesses of 20th century jazz & soul pioneers with phrases inspired by the lyrics of the songs they were best known for. The intention is to create part tribute to the artist, part inspiration for the viewer, part simple affirmation of joy.
In many cases the original one-off artwork is also available, painted in brilliant, durable, signwriter's enamel on a custom made aluminium panel. Please enquire for bespoke portrait commissions in the style of the SoulStars prints at email@example.com.
About MrWooWoo
MrWooWoo is Rudy de Belgeonne, a Slade-trained artist whose fascination with puzzles and game play led him into a career first as a digital games producer, then into the field of Experience Design. Most of all, he is interested in the space where physical and digital meet, having created digital interactive artworks, as well as furniture, paintings and prints. There is currently a waiting list for bespoke portrait commissions in the style of the SoulStars prints. For more information please contact firstname.lastname@example.com
Sweetest Hangover comes in two edition sizes.
Small (500mm x 610mm) edition of 250.
Large (800mm x 960mm) edition of 100


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|"Xavier Hanin (JIRA)" <j...@apache.org>
|[jira] Commented: (IVYDE-88) Add new target to build.xml to build the plugin with Ant
|Wed, 16 Apr 2008 07:26:22 GMT
[ https://issues.apache.org/jira/browse/IVYDE-88?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=12589446#action_12589446 ] Xavier Hanin commented on IVYDE-88: ----------------------------------- I'm fine with applying this patch and changing the layout in svn, I trust you that it's the easiest way to have a command line build for IvyDE, which will help releasing and maybe having more people contributing patches. BTW, I see you've changed the bundle version from 1.3 to 2.0.0 for IvyDE, maybe we could discuss this on mailing list? > Add new target to build.xml to build the plugin with Ant > -------------------------------------------------------- > > Key: IVYDE-88 > URL: https://issues.apache.org/jira/browse/IVYDE-88 > Project: IvyDE > Issue Type: Improvement > Reporter: Maarten Coene > Attachments: build.patch > > > In order to add IvyDE to gump, we need an Ant target to create the plugin. > In addition, this target could be very usefull for people wanting to build the plugin theirself. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online.
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