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Wormwood is primarily used as a bitter and therefore has the effect of stimulating and invigorating the whole of the digestive process. It may be used where there is indigestion, especially when due to a deficient quantity or quality of gastric juice. It is a powerful remedy in the treatment of worm infestations, especially roundworm and pinworm. It may also be used to help the body deal with fever and infections.
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Eddy Raven
- Overview
- Biography
- Songs
- Browse by Format
- Browse by Genres
- Similar Artists
|Cajun & Zydeco Country & Bluegrass Holiday & Seasonal
|country classic country krica morena bela aleyster crowley bernardo de andrade
|1960s 1970s 1980s 1990s 2000s
|discogs lyrics official homepage VIAF wikidata wikipedia
Edward Garvin Futch, 19 August 1944, Lafayette, Louisiana, USA. Futch, one of 11 children, was raised in bayou country. His father, a truck driver and blues guitarist, used to take him to honky tonks. He was given a guitar, and by the time he was 13 years old, he was playing in a rock n roll band. When the family moved to Georgia in 1960, he worked for a radio station and recorded his own song, Once A Fool, as Eddy Raven for the small Cosmo label. They returned to Lafayette in 1963 and Raven worked in La Louisianne record store and also made singles for the owners label. In 1969 he recorded That Crazy Cajun Sound, which impressed Jimmy C. Newman, who then secured Raven a songwriting contract in Nashville with Acuff-Rose. He also worked as lead singer for Jimmie Davis band and toured with him during an election campaign for Governor of Louisiana.
In 1971 Don Gibson had a Top 5 US country hit with...
- MatchEddy Raven
- 100%Janie Fricke
- 100%T. G. Sheppard
- 100%T.G. Sheppard
- 92%Earl Thomas Conley
- 80%Charly McClain
- 80%John Conlee
- 79%Holly Dunn
- 79%T. Graham Brown
- 76%Ricky Van Shelton
- 74%Kendalls

subset: commoncrawl


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Series: Cambridge Studies in Biological and Evolutionary Anthropology Volume: 11
378 pages, 70 line diagrams 1 half-tone 42 tables
Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.
'A well-documented, clearly written, scholarly text.' S. Antonarakis, Trends in Genetics 'By far the best introduction to the subject that I have read.' D. Weatherall, Science Publicity
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Next we have to switch from DNA to RNA
...but DNA is too big to leave the nucleus
Knowledge Check
Adenine - Thymine
Cytosine - Guanine
DNA vs RNA
Major Structural Differences
From DNA to Protein
Translation is the process of turning mRNA into protein
Translate from one "language" (mRNA nucleotides) to a second "language" (amino acids)
Genetic code – nucleotide sequence that is translated to amino acids of the protein
Central Dogma of Biology
DNA is the genetic instruction or gene
DNA to RNA is called
RNA to Protein is called
Modern Genetics - From DNA to How You Look...
RNA Structure
RNA differs from DNA
Ribose is the sugar rather than deoxyribose
Uracil instead of Thymine
A, G and C the same
Single stranded
Similarities and Differences
Open and unwind a portion of the DNA
1 strand of the DNA acts as a template
Complementary base-pairing with DNA
DNA the Background
Kicking it back to the Cell Cycle
DNA Makes a Copy of Itself
Guiding Questions
What is DNA?
How does it control what we look like?
What is the Central Dogma of Biology?
Discovering the Structure
Who cares about...DNA?!?
Watson and Crick are credited with "discovery" the structure of DNA
Rosalind Franklin research crystallography, which was "stolen" by Watson and Crick
In English...
Deoxyribose Nucleic Acid
Called DNA
Includes a phosphate group,a nitrogenous base, and a sugar
Deoxyribose is sugar
Nitrogenous bases:
Called RNA
Has ribose as sugar
Nitrogenous base pairs Adenine - Uracil Cytosine - Guanine
Single stranded
The process of making more DNA (DNA replication) requires the use of RNA and enzymes
Helicase unwinds the double helix of DNA strand
RNA primers (base pairs A-U, C-G) begin to match up with the strands
DNA polymerase combines with the strand to match up the base pairs (A-T, C-G)
Two identical strands are formed
Occurs in the nucleus of the cell
messenger RNA (mRNA) – codes for proteins
ribosomal RNA (rRNA) – makes proteins
transfer RNA (tRNA) – carries the amino acid
RNA strand does not stay paired with DNA
DNA re-coils and RNA is single stranded
RNA is shorter than DNA
Adenine - Uracil
Cytosine - Guanine
DNA Replication
DNA Transcription
Nucleotides read 3 at a time meaning that there are 64 combinations for a codon (set of 3 nucleotides)
Only 20 amino acids
More than 1 codon per AA – degenerate code with the exception of Met and Trp (least abundant AAs in proteins)
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Trusted Family Advisor
It is our mission to be your trusted family advisor as you plan and protect your loved ones and assets through trusts, wills, child guardianship, probate, trust administration, special needs planning, and small business planning.
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While transferring material wealth to future generations is a wonderful blessing, it is only the tip of the iceberg. At KR Hess Law, we walk our clients through an invaluable process of Creating Legacies that Last to capture your intangible family wealth—intellectual, spiritual, and human assets—for future generations.
Estate Planning Resources
Free Resources to stay informed about current and upcoming Estate Planning issues on our Blog, Newsletter and Podcast


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Home | Melbourne Zoo | Zoo Information
This is basic Information for the Australian Melbourne Zoo helping you get there, find your way around and anything else that will make the experience an enjoyable one.
The Royal Melbourne Zoo is Australia's first being built in 1862 and now houses over 460 animal species.
Some of these animals are on the highly endangered list with their numbers dangerously low.
All the animals are housed in humane modern exhibition sections
scattered throughout the grounds and well looked after by qualified and
dedicated zoo staff.
Navigate The Melbourne Zoo
Animals were originally displayed at the Royal Botanic Gardens and then in the Richmond Paddocks along the Yarra River.
In 1862 the animals were moved to Royal park.
The layout of the Melbourne Zoo was modeled after the London Zoo with lots of formal gardens.
In the early days the elephants were used for rides, Queenie being one of the favorite elephants, however this practice ceased in 1961 due to an unfortunate incident.
I even remember as an early child in the 50's riding on an elephant through the zoo lawns.
Historical Photo Of Queenie The Elephant At The Melbourne Zoo
At the Zoo Children's Hour artists 'Happy memories of 3LO Melbourne'
Now the elephants live in the modern and spacious Trail of the Elephants.
Over the years the Zoo has been remodeled and redeveloped and there are more humane enclosures always being built.
One relic of the Melbourne Zoo is the restored and heritage listed 19th Century English-made-Merry-Go-Round.
Now beautifully restored it operates in the Carousel Park at the Zoo between the hours of 11:30 and 2:00pm during weekends, public holidays and school holidays.
Melbourne Zoo Carousel
It is situated just on the outskirts of the central business district.
Just click the blue icon on the map below for directions or click through to a larger map.
Melways reference 43 E1
By Road
If you are traveling in by car just click on the map above and follow the prompts. You will be given an exact route to travel from your starting point.
Parking is available for a very small fee, just follow the directions from Elliot Street.
Public Transport
Royal Park Train Station - The Melbourne Zoo Stop
Where to Eat - Important Zoo Information
Apart from packing a delicious picnic there are plenty of places within the grounds to either snack or sit down dine.
A Little Bit of Asia at the Melbourne Zoo - Eatery And Gift Shop
There are plenty of open spaces for you to set up your very own picnic. Whether it be a rug on the lawn or a picnic table and chairs, you are sure to enjoy the experience while listening to all the different noises that the animals are making.
Picnic At Melbourne Zoo
The Zoo Shops
The Melbourne Zoo Shop
Melbourne Zoo Phone Number: (03) 9285 9300
Please check with the official Melbourne Zoo site for any price updates:
As of July 2010;
Adults--$24:80 16 and over
Children--$12:40 4 through to 15
Concession--$19:20 16 and over
Seniors Concession--$22:30
Discounted Family Passes are available as well as reduced disabled admission.
Carers are admitted for free.
Purchase tickets on line here at Royal Melbourne Zoo site
Save yourself some time and money and skip those long queues. Check out the advantages of purchasing a Melbourne Sightseeing and Attraction Pass.
You can choose between a ...
For More Information Click onto the Banner Below
The Zoo is open between 9:00am and 5:00pm every day of the year.
Allow a good 3 hours to see all the animals and if you wish to Meet the Keeper these are the special times...
Meet the Keeper Presentations:
Sign Post At The Royal Melbourne Zoo
Want to know what animals are exhibited at the Melbourne Zoo?
Hop on over to the Zoo Exhibits page for more zoo information.
Drive through an open plain with wild African animals to the left and right of you, feed a Kangaroo or pat a Koala?
There is so much to see at the Melbourne Zoo
Check out more information on Melbourne - Australia.
Please note that some links on this page are to companies that I have an affiliation with. By that I mean that if you purchase a product through them I receive a very small commission. This way of earning income is termed Monetization and it is a way for me to keep my site out here for you to enjoy. I will only affiliate with companies that I feel offer value for money and excellent back up service. These are Companies that I personally have used to purchase products for myself, my family and my friends. To learn more please refer to my Disclaimer page
Stay right in the heart of Melbourne. Close to shopping, transport, Melbourne's attractions.
Experience Melbourne's friendly coffee culture, the art precinct and of course the exciting live theatre shows.
Check Availability, Rates and Best Deals going.
Just use the Search box here, fill in your dates and see where's the best place for you to stay.
Please note that some links on this page are to companies that I have an affiliation with. By that I mean that if you purchase a product through them I receive a very small commission. This way of earning income is termed Monetization and it is a way for me to keep my site out here for you to enjoy. I will only affiliate with companies that I feel offer value for money and excellent back up service. These are Companies that I personally have used to purchase products for myself, my family and my friends. To learn more please refer to my Disclaimer page
Use this to check the UV in your area, click on the down arrow for location closest to you
And Don't Forget To Be Sun Smart
You cannot feel or see UV (Ultraviolet radiation). We can see the sun's light and we can feel the sun's warmth (the infrared radiation). Our senses don't pick up on UV radiation and this is why it is so damaging.
Right across Australia this UV radiation varies, it being determined by the time of day, time of year, the weather including cloud cover, how close to the equator the position is and other considerable scientific factors.


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Visit Coupons.com to snag a $.25/1 Clorox Liquid Bleach printable coupon. Clorox has so many cleaning uses, I always have it in the house!
I know you all love printable coupons as much as I do. Want more? Make sure to check out coupons.com, RedPlum, Coupon Network, SmartSource and SavingStar for more printable coupons!
Check out HOT Amazon deals on your favorite items!


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People have been using massage oils for therapeutic treatments and for general relaxation for many years. A search of the medical news items on the web or in the paper will often point to the many benefits that massage can offer. The oils come in many different styles and even scents, and they help to accentuate the power of the massage. Some of the oils will heat up when applied to the skin, which can provide an added bit of heat therapy to the overall massage. No matter your need, chances are that you will be able to find an oil that's right for your purposes.
Someone who works in the field of massage as a professional will want to have many different varieties of massage oils on hand at all times. Some clients may have allergies to certain types of oils, and it's important to have alternate options for those individuals. Others may not want you to use any scented oils, so having some of the plain, unscented oils on hand is always a good idea.
When buying the oils, you need to make sure that you are buying quality. While the price of the oil might be important to you, it's a good idea to check the ingredients and make sure that the oil is high quality. Buying oil that is slightly more expensive but will last longer and work better is a smarter option than buying the cheapest oils you can find. You want your clients to be happy, and one of the best ways to ensure that happens is by using the best and providing them with a great service.
In terms of price, the massage oils will vary based on the type of oil in question. Some of the oils with aromatherapy properties may be more expensive than standard massage oil. You can find the oils you need in a variety of different places, online and offline, and the prices can differ. Find a supplier that has the types of oil you need, and who will be able to offer you a good price for the best quality oil. Those who are running a business with a number of clients will probably want to order the massage oils in large quantities since you will be using more of them. Ordering a lot at of the product at one time can often save you money. Experiment with some of the oils and find the ones that work best for your needs.


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Okay I have a Mac and This Annoying Robot Voice Keeps Talking Whatever I type or whatever site I'm on?
Should be easy to fix- Go to the apple menu (upper left corner of your desktop), select system preferences, then Universal Access, then turn Voice Over OFF. You might have hit Command F5 by accident!
Does it looks like i have man boobs or ****** **** or whatever you want to call it?
Yup, you've got man boobs bigger than most women I know.
Is there even 1 person who can honestly say that they make money online like with google or whatever?
These Guys are BBB accredited and pay you $5 just to sign up.http://www.fusioncash.net/?ref=coinman93…These guys are also good.http://www.cash4free.com/?ref=616786These guys do pay outNOTE: these...
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Who sings"Lean Like a Chola"?
Carmen, the Boston-based singer of the Bodega Girls, sings "Lean Like a Chola," which is a spoof on the song "Lean Like a Cholo" by Down Aka Kilo. Carmen also sings the song "Time to Move."Source:L...
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Who sings the song"Fly Like an Eagle"?
The song "Fly Like an Eagle" was performed by the American rock group, The Steve Miller Band. The song appeared on the album of the same name and was released by Digital Sound in 1976.References:eL...
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Declining U.S. timberland investing acreage leaves questions as to what investors can expect in 2011 and beyond; DANA's Dennis Neilson to address trends in free i2live audio conference call Aug. 11
August 2, 2011
(press release)
– Between 2002 and 2008, U.S. timberland investors had abundant domestic investing opportunities -- yearly transactions never fell below three million acres, and actually surpassed nine million acres in 2005. But in recent years investing opportunities have all but evaporated. By 2010, with forest product company land gone, investing acreage fell to less than one million acres, and in 2011 it will not be a lot better.
With the timberland investing "surge" now over, what are the trends investors can expect in 2011 and beyond? Dennis Neilson will address this and other questions in an audio conference call sponsored by Industry Intelligence on August 11. In the call, Neilson will provide an overview of the findings of DANA Ltd.'s soon-to-be-published sixth edition of International Timberlands Ownership and Investment Review.
The 2011 edition profiles more than 1,050 land owners and direct investors/funds from around the world. It also covers 55 Sovereign Wealth Funds, 95 North American pension funds, as well as 63 overseas pension funds that have, or are looking to invest in timberlands. The report also has chapters on global tree carbon offset trading trends, several overseas regional investment options, and data and discussion on timberland investment returns. Changing return expectations are a major source of debate in 2011. Does the T-NCREIF Index fairly measure returns in the medium term, or are changes required? With the USA domestic volatility/decline in log prices over the last decade, should all overseas timberland projects attract risk premia over domestic options, or should that perhaps be reversed for some investments?
To participate in this free audio call, please sign up at www.industryintel.com/i2live
International timberland investment trends -- what comes after the "surge"? Identify opportunities. Evaluate risk.
Thursday, August 11, 2:00 PM ET/18:00 GMT
Dennis Neilson, director, DANA Ltd., New Zealand
About Industry Intelligence Inc.
Industry Intelligence specializes in providing market intelligence solutions that offer a comprehensive view of business and market-moving events—all within an intuitive, easy-to use platform that promotes collaboration and action. Founded in 1999, privately held and headquartered in Los Angeles, Industry Intelligence has worked with more than 600 companies of all sizes and across diverse market sectors.
i2live interactive conference programs engage business leaders in an ongoing conversation among experts and peers. i2live audio calls, speakers' series and conferences cover topics tailored to your industry and issues that cut across market sectors to help businesses make sense of industry trends and get real-time intelligence. For more information, please visit http://industryintel.com/i2live.
About DANA Limited
Dana Limited is a New Zealand based forest industry publishing and consulting business. It has published/co-authored more than 40 multi-client reviews, including multi-country/global Reviews on timberland ownership/investment, tree plantation economics and woodfibre trade. It also consults to a number of international organizations on a variety of forestry topics; and has organized several global travel programs for clients to visit forestry operations and wood product markets.
* All content is copyrighted by Industry Intelligence, or the original respective author or source. You may not recirculate, redistrubte or publish the analysis and presentation included in the service without Industry Intelligence's prior written consent. Please review our terms of use.


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Social security and Medicare need a recalibration to face the current economical realities. Older Americans should not bear the brunt of this as they have put so much into the system already and deserve the benefits promised to them.
Leaving Social Security on auto pilot and allowing it to continue to grow beyond its means is no longer an option. Based on current projections, Social Security will be unable to fulfill its obligations in 2033 and Medicare is not too far behind that.
Social Security & Medicare accounted for a combined 41% of the government's budget in 2011 amounting to almost $1.5 trillion dollars. These numbers are expected to rise as more baby boomers collect the benefits of these programs for longer periods of time due to an increased life expectancy.
A new social contract must be struck with the younger generation, my generation. While we still need to pay into the system, the benefits for us in the future will not be as high as the current social security payments being received. Either cuts to benefits or an increase in taxes have been recommended by the powers that be.
Source: http://voteforeddie.com/issues.php


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Kim Kardashian, who is a master at manipulating the spotlight, is avoiding the press and fans -- for the moment.
Usually very active on Twitter, Kim hasn't put out a tweet for nearly 24 hours - since before her divorce news hit Monday morning.
More: Will divorce tarnish Kim's brand?
The reality starlet was bombarded by paparazzi cameras as she left her Beverly Hills home Monday evening, reports E!, heading for LAX to catch a plane to Australia, where she is scheduled to promote a new handbag line.
Kim, who wasn't wearing her giant wedding and engagement rings as she headed to the airport, is flying to Sydney with her sister Khloé.
The family, in the meantime, is circling the wagons. Mom Kris didn't mention the breakup last night as she peddled fashions on QVC. Backstage at last night's Dancing With the Stars, Rob Kardashian, who had his best night yet, told E!: "My sister is obviously going through a lot and we're obviously very supportive of whatever decision she makes. We're just here as her family just to be with her and be on her side for whatever."
Sign up for Lifeline Live e-mail alerts


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When the mall Arkaden in central Gothenburg was to be Christmas decorated the demands were set high. The mall houses 25 stores specialized in fashion, design and interior design, so a Christmas decoration at least as fashionable as the stores was needed.
Brand Factory in Gothenburg had the honor to take on the task together with Demo Eventproduktion. We made both interior and exterior Christmas decorations, including wrappings in a neat Christmas design on the glass of the escalator and the entrance – naturally to the visitors' delight!
Above you can see photos of the interior and exterior decorations.
Do you want to know more about the project? Contact Ola Bäckman, Sales at Brand Factory.


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Uranium Resources, Inc. (URI) is focused on advancing to near-term production the Temrezli in-situ recovery (ISR) project in Central Turkey. URI also controls extensive exploration properties under nine exploration and operating licenses covering approximately 44,700 acres (over 18,000 ha) with numerous exploration targets, including the potential satellite Sefaatli Project, which is 25 miles (40 km) southwest of the Temrezli Project.
In Texas, the Company has two licensed and currently idled processing facilities and approximately 17,000 acres (6,900 ha) of prospective ISR projects. In New Mexico, the Company holds a federal Nuclear Regulatory Commission license to recover up to three million pounds of uranium per year using the ISR process at certain properties and controls minerals rights encompassing approximately 190,000 acres (76,900 ha) in the prolific Grants Mineral Belt in New Mexico, which holds one of the largest known concentrations of sandstone-hosted uranium deposits in the world. Incorporated in 1977, URI also owns an extensive uranium information database of historic drill hole logs, assay certificates, maps and technical reports for the Western United States.
©2015 Uranium Resources, Inc.
All Rights Reserved
Home | Site Map | Cautionary Note to Investors | Industry Terms


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Volunteer Stories
Just call him Surrey's super volunteer.
Michael is a fixture with the Lookout Society Surrey, working almost daily for the last two years.
Much of the work he does is connected to the health services, such as the Djaef Mahler Grocery -- a specialized food bank that provides high protein food items for people who are compromised immune systems– primarily HIV and Hep C.
When the food bank isn't open, you'll find him helping where there's a need," says Sat Basran, Manager of Health Programs.
"He's a real gem and we're lucky to have him involved," says Sat. "Michael is very dedicated."
There`s no question where Michael`s motivation comes from.
In January, 2007 he was diagnosed with a sarcoma cancer, linked to his HIV infection. His doctors estimated he had just months to live.
Several rounds of chemotherapy followed and the cancer became less aggressive. Michael began eating higher protein foods, like those offered through the Djaef Mahler Grocery.
It obviously made a difference because in 2012 he was pronounced cancer free.
"I felt I was really fortunate to have fought and defeated that cancer," says Michael. "Now I'm free of cancer so why stand still?
"I can help people and give them advice because of what I've been through."
• Volunteers are essential to the services and programs the Lookout Society offers. If you`re interested in volunteering, contact Janice at email@example.com or apply directly on our volunteer signup webpage.


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At the end of December 2017, the term of the TFRW officers presently serving will end. It is now time to prepare for nominations for TFRW Officers for the term of 2018-2019. The nominating committee has prepared the following forms which can be downloaded if are you interested in running for a TFRW office.
Linda D. Buckles
TFRW President
To view information from the Nominating Committee, click here.


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Pete is missing in Washington, DC! Last seen near Mass Ave SE & 17 Street SE at 10:30 am on 3/12/14. He was hit by a car and kept running. Pete was last seen going towards the Whitney Young Memorial Bridge/RFK Stadium towards ESE. He is friendly, but shy. He is wearing a collar with tags and microchipped. Call 541-285-3621 if seen! Please email firstname.lastname@example.com with any information or to help us search for Pete!
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TESARO, Inc. (NASDAQ:TSRO)
UBS 2014 Global Healthcare Conference
May 21, 2014 08:00 a.m. ET
Dr. Mary Lynne Hedley – President
Andrew Peters – UBS
Andrew Peters
Good morning and welcome everyone to the final day of the 2014 UBS Global Healthcare Conference. My name is Andrew Peters, and I am the small and mid-cap biotech analyst here at UBS. It is my great pleasure this morning to introduce TESARO and speaking on their behalf is Dr. Mary Lynne Hedley, Founder and President of the company. Afterwards we will be hosting a breakout session in the Carnegie West room across the hall. Thank you.
Dr. Mary Lynne Hedley
Thank you Andrew and thank you everybody for being here this morning. So as a reminder, I will be making forward-looking statements during this presentation, and I refer you to our SEC filings for further information.
Four years ago TESARO was founded with a mission to improve the lives of cancer patients by acquiring, developing and commercializing oncology products. Since that time, we have created a portfolio of eight oncology development products. We are preparing to submit our first NDA in the middle of this year, and we are beginning to prepare the company for its first commercial launch.
Our portfolio is balanced by risk and development stage, and includes Rolapitant, an NK-1 receptor antagonist for the prevention of chemotherapy induced nausea and vomiting, which will be the subject of our first NDA submission. Niraparib, our Phase III product candidate in development for breast and ovarian cancer patients, TSR-011, our ALK/TRK compound in Phase I development and our preclinical immuno-oncology basket of products.
I will now spend some time going through each of these product candidates. Rolapitant is a long-acting NK-1 receptor antagonist being developed for the prevention of chemotherapy-induced nausea and vomiting. Nausea and vomiting are symptoms that can occur in a patient for up to 5 days post a single dose of chemotherapy.
We recently reported the top line results from our registration program of Rolapitant and these results continue to support a differentiated product profile. Rolapitant is differentiated based on activity, safety and convenience. A single dose of Rolapitant reduces the number of patients who experienced the symptoms of nausea and vomiting compared to standard therapy. Rolapitant is not encumbered by CYP3A4 drug interactions, and eventually an oral and IV formulation will be available to fully recognize the global market opportunity.
Our registration program consisted of three pivotal Phase III trials conducted in over 2400 patients, receiving different types of chemotherapy. These were randomized, well controlled, double blinded studies in which patients received either standard therapy or standard therapy plus Rolapitant. The primary endpoint was complete response or no emesis or use of rescue medications in the delayed phase. And as I indicated, we recently reported that we achieved the primary end point in all three of these trials.
We look forward to updating you on the data from these trials at ASCO and MASCC, which is a supportive care cancer meeting that occurs shortly after ASCO. The data that will be presented at this meeting includes analysis of the secondary endpoints as well as an important subgroup analysis of 459 patients from the MEC study. This is an important analysis because it primarily includes patients receiving anthracycline/cyclophosphamide or carboplatin, which represents the largest segment of the US market.
Patients receiving anthracycline/cyclophosphamide and carboplatin represent about 85% to 90% of the overall number of patients who by NCCN and ASCO guidelines have been recommended to receive an NK-1 receptor antagonist. The remaining 10% to 15% of patients are those receiving cisplatin. If we take the 5 million patients represented by this pie, and we dollarize it to the current price of Emend, the only other marketed NK-1 receptor antagonist, we see that there is a market opportunity of 1.5 billion for Rolapitant.
Now if we look at the current sales of Emend, we see that they have penetrated only about 20% of the market opportunity, and most of the uses in patients receiving cisplatin. So our opportunity is to convince physicians to follow the NCCN and ASCO guidelines and treat the remaining over 4 million patients, who are receiving anthracycline/cyclophosphamide with an NK-1 receptor antagonist.
In the US market, anti-emetic agents are available typically as both oral and IV formulations. The IV use in the US represents about 80% of the market opportunity. You can see here the significant revenue potential for Rolapitant should it achieve different market shares of both the IV and the oral formulation.
We intend to launch the oral formulation of Rolapitant in the middle of next year and about a year later follow with the IV formulation. We believe that the differentiation of Rolapitant coupled with appropriate promotional activity and a focus on educational activity encouraging physicians and healthcare providers to treat patients according to the NCCN and ASCO guidelines, coupled with our unique ability to partner with oncology clinics will well position Rolapitant for future market gain.
Approximately 120 people will support these commercial efforts. These include field-based as well as home-based associates, and importantly once Rolapitant achieves an annual run rate of about 50 million to 60 million will achieve a breakeven for the P&L for this brand.
Moving on to Niraparib. Niraparib is an orally active potent PARP inhibitor. It was the subject of a Phase I clinical study conducted in over 100 advanced cancer patients and in this trial clinical activity was demonstrated, in particular in group of patients with a genetic and clinical marker, as well as a well tolerated dose and a dose for moving forward into Phase III was identified.
We have since initiated two Phase III trials with Niraparib, including in patients who have breast or ovarian cancer, and we have recently initiated a combination chemotherapy study with temozolomide in patients with Ewing's sarcoma. The Phase I results were stunning on a couple of levels. First the very high incidence of response rate and these were response rates that range from 75% to 50% in the target population that we are studying in Phase III.
In addition the durability of these responses was profound. A median of over 450 days in patients that have the genetic marker as well as patients who did not have the genetic marker. The adverse event profile for this drug was typical for PARP inhibitors and the dose-limiting toxicity was identified as thrombocytopenia.
Since that time we have initiated two Phase III studies and we are focusing these studies on patients who are enriched for either a genetic marker or certain clinical characteristics based on the Phase I data and the scientific literature. In the ovarian trial, we are enrolling patients with high-grade serous ovarian cancers, who are platinum sensitive. These patients either contain a germline BRCA mutation or a non-germline BRCA mutation. Each cohort is randomized 2 to 1 to receive Niraparib or control, and the primary endpoint is PFS.
In addition, in a genetically targeted patient population of breast cancer patients we are exploring the activity of Niraparib in comparison to physician's choice in the metastatic setting. Again patients are randomized 2 to 1 to receive Niraparib or control and the primary endpoint is PFS.
Simply focusing on the breast and ovarian cancer patient populations, these two indications in the US and Europe only represent a significant market opportunity over $3 billion for Niraparib. Of course we and others in the field believe that PARP inhibitors can target other potential indications, and we look forward to updating you at our ASCO event, our investor event on Sunday night as to our thinking related to additional indications for Niraparib.
Moving on to 011. TSR-011 is our ALK/TRK inhibitor. It is very potent and selective and has demonstrated in preclinical models the ability to stop the proliferation and kill cancer cells that are driven by ALK or TRK genetic mutations. In addition, animal models demonstrate that this inhibitor can cause tumor regression in these driven tumors.
We initiated a Phase I dose escalation cohort expansion clinical study with TSR-011, in which we identified a dose which led to very impressive clinical results. In particular in ALK positive patients that had progressed on a first generation ALK inhibitor. Since that time we have enrolled 11 additional patients with ALK or TRK mutations at a fractionated dose of TSR-011 to optimize the PK, PD profile and we look forward to updating you on the clinical results from this study in a meeting in the fall.
And finally our immuno-oncology portfolio. The rationale for recently [in-licensing] an immuno-oncology portfolio is based on our belief that immuno-oncology will at some point in the near future form the basis for many baseline cancer therapies. In addition, we believe that it is the combination of immunotherapy agents together with either other immuno-oncology drugs or small molecules such as those potentially in our own pipeline, which will provide the best care for patients in the future.
And finally, we believe that having a basket of immuno-oncology compounds represents a significant opportunity for us to partner with additional companies and collaborators who are interested in exploring immuno-oncology combinations with their own agents. Our current basket consists of three antibody candidates that are targeted to PD-1, LAG-3 and TIM-3. PD-1, LAG-3 and TIM-3 are known as checkpoint proteins, and these proteins are important because they send a negative signal into T cells and when they inhibit that T cell response, the T cells are no longer able to kill the tumors.
Tumors have evolved a unique mechanism to express the ligand for these three checkpoint proteins and in so doing inhibit the killing of the tumor cells, when the T cells come into the tumor microenvironment. It has been demonstrated both preclinically and now clinically with PD-1 antibodies that blocks the interaction between the T-cell and the tumor that you can reinvigorate that T-cell response, which leads to very long, durable clinical benefit in patients.
The excitement with the PD-1 antibodies that currently exist in this space have spurred the interest in several additional checkpoint molecules, and two of the most promising include TIM-3 and LAG-3. Our goal is to move our PD-1 antibody TSR-042 into the clinic in the second half of next year, and this will be shortly followed by antibodies for TIM-3 and LAG-3.
I hope you can see that TESARO is well positioned for success. We have near-term revenue opportunities, most notably with Rolapitant, which represents a $1.5 billion market opportunity simply in the US alone. We have a very promising pipeline with the further development of an IV formulation of Rolapitant, two ongoing Phase III global trials that are currently enrolling breast and ovarian patients with Niraparib, the ability to potentially expand the Niraparib franchise beyond breast and ovarian cancer, TSR-011, which has demonstrated compelling activity in ALK positive tumor patients, which have progressed on our first generation ALK inhibitor, and finally our very interesting basket of immuno-oncology products, which positions us well to take advantage of the excitement and potential patient benefit of this class of agents.
We are a well capitalized company. On our last earnings call we reported 180 million in cash and cash equivalents and net proceeds of over 94 million from a follow-on offering in February, and finally we have done it before. So we are an experienced team. We have launched products and developed oncology products in this space.
Our additional priorities for 2014 include presenting data at upcoming medical meetings, submitting an NDA for Rolapitant in the middle of this year, advancing the IV Rolapitant program, continuing to advance the Niraparib program, expanding the Niraparib program into other indications, continuing the development of 011 and setting ourselves up for a registration study and finally advancing the immuno-oncology basket of products. Thank you very much.
Question-and-Answer Session
[No formal Q&A session for this event]
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|Eileen Hughes
|Bus conductor
|First appearance
|20th January 1961
|Last appearance
|24th February 1961
|Number of appearances
|Played by
|Prunella Scales
Eileen Hughes was a bus conductor who worked with Harry Hewitt. In 1961, she fought with Florrie Lindley for Harry's affections and drove him to distraction when he was competing for the Rovers darts team against Eileen's team. On Harry's birthday, Eileen visited while Harry was enjoying a birthday dinner with Florrie and his daughter Lucille, much to Florrie's chagrin. Despite Eileen and Florrie's attempts to catch his eye, Harry was not actually attracted to either woman.
- Future Fawlty Towers actress Prunella Scales played the part of Eileen.


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|Home > Guthrey
♂ Guthrey
What does Guthrey mean?
Guthrey [guthrey] as a boys' name means "windy spot". Guthrey is an alternate spelling of Guthrie (Irish, Gaelic): place name.
VARIANTS Guthry, GuthreeCREATIVE FORMS
(male) Gethrey, Gothrey, ..
(female) Guthly, Guthne, .. MIDDLE NAME PAIRINGS
Guthrey Mateo (G.M.), ..
How popular is Guthrey?
Guthrey is an unusual first name for men but a somewhat prominent surname for all people (#84310 out of 150436, Top 56%). (2000 U.S. CENSUS)
Which version is better?with its source form and related boy names. Guthrie is the only prominent related form of Guthrey (NOT RANKED) ranked in the Top 2000. Other forms, like Guthry, are uncommon. This form of Guthrey was at the top of its popularity during 1890-1899. (2015 BIRTH STATISTICS)
Similar NamesRecommended names are Aubrey▼, Autrey, Currey, Garey, Garrey, Gauthier, Gearey, Geffrey, Geofrey, Gerrey, Godfrey, Grey▲, Guaire, Gunther, Humfrey, Humphrey, Jephrey, Jophrey, Murrey and Rutley. These names tend to be more frequently used than Guthrey.See names in meaning and etymology.


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Captain Planet TV Movie Announced
July 20, 2011 by Post Team
Captain Planet TV Movie Announced, Some may have thought that happened in 2007 with the release of the live-action Underdog movie (starring Jim Belushi, Peter Dinklage and Mayor Roger Sterling!). Others say that occurred last year, with the green light a movie Ant-Man. But Grantland us are willing to call: Tuesday, July 19, 2011. The Hollywood ran out of official day of superheroes.
Yes, indeed. Use your layers at half-mast and fire 21 (non-organic!) web-shooter greeting. Because today our spandex saturated the entertainment industry finally hit rock bottom with the announcement of a live-action film based on Captain Planet and the Planeteers. You read that right: Captain Planet, an environmental blue ideologue exactly loved by anyone, a character that will go down in history as the second worst Ted Turner's idea (just before trying to popularize bison meat and well behind the cut Tomahawk) will be raised to the big screen. And all I can say is: Why?
Captain Planet came a momentary explosion of cultural optimism linked to the 20 Anniversary of Earth Day in 1990, a period marked by rising Greenpeace booths at concerts, not highlighted by the Indigo Girls and the innovative invention of paper Yellow recycling (which, by the way, also make a great movie). The character was a mullet, square-jawed zero tried to save the world with his powers of weather manipulation (no one says Al Gore!). He hung out with a rainbow coalition of five teens from various backgrounds (one of Africa!) Call planetariums and fought against evil, polluting villains with names like pig Greedly, looting Looten, Skumm verminous, and Tony Hayward. It was an interesting figure for a movement that, although worthy, boring to everyone not named Greenzo. By far the most memorable of Captain Planet is a rogue's gallery of Hollywood do good hired by Turner – certainly for a bison hunt spirit – the voice of the villains in the cartoon, a rare class list, including James Coburn, Meg Ryan, Jeff Goldblum, Ed Asner, Dean Stockwell, Martin Sheen, and Sting. (All of them rescued in the project after the first season of All but Asner -. Pro a professional) unless the undead members of that group are still getting calls from Turner, there's really nothing here to suggest a film action that would be of interest to anyone outside the most pedantic chapter of the Sierra Club in the world.
What is worse? No need to signal the end of a lucrative genre film (eco-friendly!) dumpster diving like this! There is still worth much more exaggerated boxes forgotten superheroes ready for close-up. Like, for example, the arm will fall Boy, whose powers are both using CGI, immediately relatable, and they're in the title. (And for the sound engineer responsible for the creation of the hand down the arm of the boy falling mark SFX – "plorp" – Make sure there is room on the mantle of reserve for an Oscar). Nonsense enough – CO2 emissions could bring Captain Planet.
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If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
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Description: 'Paganism' is an evocative word that, even today, conjures up deep-seated emotions and prejudices. Until recently, it was primarily a derogatory term used by Christians to describe the non-Christian cultures confronted and vanquished by their Churches. For some it evokes images of sacrifice and barbaric behaviour, while for others it symbolises a peace-loving, nature-worshipping spiritual relationship with the earth. This Very Short Introduction explores the meaning of paganism - through a chronological overview of the attitudes towards its practices and beliefs - from the ancient world through to the present day. Owen Davies largely looks at paganism through the eyes of the Christian world, and how, over the centuries, notions and representations of its nature were shaped by religious conflict, power struggles, colonialism, and scholarship. Despite the expansion of Christianity and Islam, Pagan cultures continue to exist around the world, whilst in the West new formations of paganism constitute one of the fastest-growing religions. Focussing on paganism in Europe, but exploring the nature of paganism globally, Davies looks at how Europeans discovered new cultures through colonial expansion, missionary work, and anthropological study. Contemporary social paganism can be a liberating and social force, and the idea of a global Pagantheology is now on the religious map.
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Copyright year: 2011Publisher: Oxford University PressPublication date: 5/26/2011Binding: PaperbackPages: 160Size: 4.50" wide x 7.00" long x 0.50" tall Weight: 0.286
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- Details
DetailsHans Dampf:~ Everything has been tuned for control and maximum riding fun. The tread functions with absolute poise and is well behaved in every situation - like difficult terrain on singletrack.
- • Performance line features top quality with dual compound tread.
- • LiteSkin construction features light, thin sidewalls for reduced weight and reduced rolling resistance.
- • 780g (26x2.35")
- • Folding bead


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Men's Sterling Silver Large Hope Pendant on Natural Cord
$ 275.00
The Anchor is a symbol of hope - secure, immovable and anchored in the Divine. This recycled sterling silver pendant, measuring approximately 7/8" in length and 5/8" in width, features an anchor and is engraved with lines radiating out from the center. This pendant hangs on a 22" natural cord with a sterling silver button closure.


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Android 5.0 Lollipop has been out for awhile, but not available to all Android users. When Apple has an update to its iOS operating system, the update is made available to all eligible devices at once, much the same way that Windows does updates.
But since the Android system is just a little bit different on every device, users have to wait until the manufacturer of their device comes up with version of the update customized for that device.
Just last Friday, I was checking for the availability of updates. I did that by going to Settings – Then About Device. A screen indicated that updates were available.
I'll warn you that when you do this update, make sure your phone is on WiFi and that you have it plugged in to the power cord. This is a massive update that uses a lot of data and it also takes a long time. My husband did the update without plugging the phone in and it took his battery power down to only 20% from nearly full. I think by the time I'd applied all of the updates it took nearly an hour. You won't be able to use your phone for calls or texts. This is definitely not a background update. First it took about 10 minutes to download the update via a WiFi connection.
Once downloaded, it was another 10 minutes to install.
After the first update installed and my phone restarted, another system update popped up.
That update also took a long time to download.
Then about another 15 minutes to install.
I hit a bit of a snag because I didn't have the required 2 GB of space available. I had to take a couple of minutes and remove some lesser-used apps.
Then the update was finally able to install. So after a little more than an hour, I had finally updated to Lollipop. Here's my homescreen before and after. I noticed that the icons for built-in apps are rounded and look more cartoonish.
The transitions do have a more fluid look to them. My main takeaway is what I feel is a hideous color scheme that I cannot change for included Android Apps. Take a look at Messages. Every time I sent or received a text this weekend, I winced.
Making a phone call now requires starting at my least favorite color on the planet.
I had no issues with anything slowing down or apps not functioning, but my co-worker Audra, who has an LG G2 phone, is experiencing a slowdown and her weather widget no longer functions, so she had to replace it with another app. Here's a look at her before and after.
Like me, she's not enthused about the color scheme in the default Android apps. How this update reacts on your device will depend on the device. I haven't used Lollipop long enough to tell you about the new features, but I'll get to work on exploring it right now.
~ Cynthia
Tags: android, Lollipop, smartphones


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Johnsonite Vinyl Transition Adaptors - #A515
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Johnsonite Vinyl Transition Adaptors
Johnsonite Standard Transition Adaptors provide smooth transitions from carpet flooring to wood, ceramic or resilient the flooring, even when floors have varying thicknesses. Made from high quality PVC, these adaptors provide the perfect, professional flooring finish.
Easy to use
Written by: - Very Happy 10/25/20165 / 5 starsProduct arrived quickly and was easy to apply with adhesive that was reccomended. Will purchase from Koffler again in the future.
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This item from The Manor's Finest - Antiques and Collectibles is now in the Shop Backroom.
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Christmas / Holiday Bell with Marcasites Accent - Signed Darlene
This bell by Darlene has a beautiful gold tone with a marcasites overlay and a rhinestone clapper. It is signed on the back. There are copies of this wonderful bell, but this one is the original. It is in excellent condition and measures 1 1/2 by 1 1/4 inches. It is a perfect size for a dress, suit, or coat for the Holidays.
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