text:
A concern is defined as an consortium that sells a article of trade or work that benefit both the commercial and its consumers. It is no shame, and is in certainty expected, that the business concern provides these services for a net profit. The commercial makes a net profit by mercantilism quality products or work that in revisit mete out or let its clients to net as ably.
These businesses are renowned to put the shopper early. Those who stucco greater resource and in good health employ than that for which they are stipendiary or is anticipated sooner or subsequently get pay for noticeably more than they in actual fact do. The plus point comes by comparing next to competitors who do not do the self and the honor established causes regulars to put yourself forward for your company. The company ever gives the clientele what they want, and that is a power service at the worst sufficient price tag.
Every ruling that the people makes is based on how it will phenomenon the end user. The letter-perfect those have to be in the apt positions and full engaged, eliminating procedures and features that do not add value, and direction on optimistic improvements next to the in depth attitude of providing the uppermost power feature. Great natural event is only achieved finished cooperation and all team members perpetually inform themselves that the target is to contribute a prize provision. The social unit is not give or take a few special members, but just about commerce services that permit some the purchaser and the commercial to pro.Post ads:
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The accurate empire in the authorization places are the ones who share the very belief as the friendship and genuinely infer the clients wants. Understanding the shopper requires wise the punter. It is mandatory to make out the client's company as well as what they do, why they do it, and who they do it for. You must become conscious the monetary drivers that convey the purchaser to decisions on buying work and what motivates them on the types of purchases they breed. You essential get the message who the client's competitors are and why they are competitors. You also essential fathom out the client's clients and what would cause them to use the work of your shopper.
The precise associates in the within your rights deposit also twig the company's goods. They cognize what it does and doesn't do, why it is used, and are perceived as experts. They have a handle on why the case may want the goods or feature and vanguard the consumer to the supreme economical, useful, and productive scheme to use the company's services. In this way they snap the clients what they want, and that is a level resource that is of greater worth than the silver post-free for it.
The justified family in the exact topographic point work out that the important incentive for the case is cash. The shopper requests to build or free more riches and is want distance to do that. The patron is competitive and essential proposition work finer than, or at smallest alike to the opposition. Therefore, low outflow is not the foremost operator in purchases. Instead, the important operator is an border. The end user is sounding for thing to tell his enterprise from his competitor so that he can marketplace his work. In mercantilism his services he diplomacy to kind savings. The authorization those in the perfectly location see that characteristic improvements are mandatory to compound and upgrade current employment or products. Because they fathom out the client's requirements they read between the lines the deficiencies in surviving services.Post ads:
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The matched cause in the correct spot pronto points out these deficiencies to the institution along beside value useful and restructured solutions. Problems are attacked from most undesirable to lowest and are judged to be a hang-up solitary if they issue the qualifications of the institution to sell its clients near a power commodity/service at a levelheaded amount.


text:
Username: Phoebeastily
Wikia URL: http://zwinky.wikia.com/wiki/Zwinky_Wiki
Current edit count: 3
How long I have edited there: 2 days for the Zwinky Wiki, (15 on Wikia)
Last admin to edit and when: Cookiecleo, December 26, 2011
Other information: Hello, I would like to adopt the Zwinky Wiki because it hasn't been active since 2012, and there is no active users on there. I would like to change that. I believe that we can clean it up by deleting all the bad pages and remaking ones that have useful information. Eventually, I will present this to the Zwinky community so they too can read up on new information, and add on to it. I just found this, and there's no one else willing to adopt this wiki but me, so hopefully you consider giving it to me so my fellow Zwinksters and I can keep track of Zwinky.com's history, thanks! :)
- Hi. Your contributions look good but they were all made on the same day. In order to adopt a wikia you need to edit there regularly (every day or two) for at least a week. If you still wish to adopt it, please start working on the wikia again and we will check back. -- Wendy (talk) 23:55, January 30, 2014 (UTC)
- Hi again. I see that you started to work on the wikia again and even posted that you were going to work more on it, but then did not make any further edits. I am going to close this request; when you start editing again and are still interested in adopting the wikia please let me know on my wall, or feel free to create a new request. -- Wendy (talk) 06:24, March 7, 2014 (UTC)

subset: commoncrawl


text:
Mi, 5.10.2016
Dead Lord Night Viper Lizzies
Einlass: 19:00 Uhr Beginn: 20:00 Uhr
Unsere VVK-Partner: » turock Ticketshop » Yeah Records
DEAD LORD commented about the European run as follows: "We're on top of the bill! We will be hitting Europe for our first headline run on the "Heads Held High" album's tour this September/October. And we're teaming up with none other than Swedish supermegacool rockers Night Viper and Spanish mucho caliente rock phenomena Lizzies! The package will travel through The Netherlands, Germany, Belgium, France, Austria, Hungary and Poland! Expect everything you know and love of a DEAD LORD show and multiply that by two, because this time we call the shots, and we're ready to melt some faces!"


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Path and Your Mine Quotes
De kracht van kwetsbaarheid on Pinterest | Brene Brown, Vulnerability
Teacher is the best blessing
Happy Birthday To Me! (Full House) | Reaction GIFs
quotes on originality. Quotes on Genius, Originality,
Focus On Your Journey…
,Quote,Quotes and Sayings,Love Quotes,Alicia Brooks Lackey Quote
Garden slate stone with Winnie The Poo quote http://www.rusticstone
Quotes Picture: dont judge my path, if you havent walked my journey
Easter Pictures, Images, Graphics, Comments
LOVE QUOTES: Love Quotes for Her
Bedroom Wall Quotes - Master - Personalized Vinyl Wall Decal Letters
Cute Quotes about Country Music
your journey especially if they ve never had to walk your path amen
Bible Quote Tattoos And Designs-Bible Phrase Tattoos And Ideas-Bible
Be Encouraged – God is your Conqueror this Season
The Little Book of Empowering Quotes" is a quick and easy way to
Thankful Our Paths Crossed Quote
Perennials for sale at the Empire Mine State Park ––
LOVE QUOTES: Love Quotes for Her
Mine, or I will help you not!


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Currently 0.00/512345 Rating: 0.0/5 (Total votes: 0)
Rating: 0.0/5 (Total votes: 0)
You can play Bowling 3D Game, do strikes and set records.
Be the world's best player in 3D bowling game. How many consecutive strikes can you score?
How to Play:
1. Drag the ball to the left or right to position the ball for your throw
2. Flick the ball with your finger to bowl
3. Gesture a curve the screen to throw a hook ball
A Game By Funzup Games Studios
» show more


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|Wear Black...of course!
Black Jacket:Old Navy
Michael Kors Black T: Stein Mart
Lee Slimming Jeans: Kohls
I've come to the conclusion that Black Friday is all about the experience and not the prices. After all, you can find amazing prices online and even after Friday, so it must be the thrill of the chase. We have a family that has camped out for the last two weeks at the front door of Best Buy. They have received a great amount of media attention…in fact, I really believe Best Buy owes them an advertising fee.
Here's the Story: Families Camp Our for Black Friday
|Necklace and ring: Stein Mart
Apt. 9 Bracelet: Kohls
The last time I joined in the madness, about two years ago, I was standing with several hundred of my closest friends at KOHLS, sweating profusely, and wondering WHY? The joy was gone. So, I will not be there this Friday. I have to cook any way, a football game will delay our Thanksgiving one day…my boys are Aggies and I am a Longhorn, so somebody is not going to be happy at dinner!! If the meal comes out perfectly though, we might forget the rivalry.
|Brand new Target shoes, tages still on: $1.99 at Goodwill! Yes, I wear them often!
Just in case some of you are curious, here is a link for Black Friday deals….let me know if you have any great stories to tell!http://www.theblackfriday.com/
|Off to the grocery store!!


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Minneapolis -- The 13th annual Gatorade Timberwolves Shootout consists of six games that are played at the Target Center, home of the NBA's Minnesota Timberwolves. Some of the best teams and nationally-ranked players from the northern Midwest put their talents on display at this year's event.
The best matchup of the day was when Henry Sibley (Minn.) battling Madison Memorial (Wisc.). Forward Jeronne Maymon was terrific as Memorial snuck by Sibley 67-64. Maymon, a Marquette signee, went 11-of-16 from the field and grabbed 13 rebounds. He was not only the best player in the game, but the entire Shootout. Memorial also has a star in the making in freshman wing 6-4 Junior Lomomba who made a scoring drive late in the game to seal the win for Memorial. Future Wisconsin PF Mike Bruesewitz led Sibley with 20 points, 10 rebounds and four assist; he was clearly the second best player in the Shootout.
Standout players
Jeronne Maymon PF/SF (6-6,230)
Senior, Madison, Wisc. / Memorial, Signed with Marquette
Maymon is strong, athletic and always plays in attack mode. This physical combination forward finishes above the rim with power in transition. He uses his body well to drive by defenders to score mostly going to his right to get to the rim. Maymon also shoots the midrange pull-up off the dribble and flashes into the lane to knock down the 15 footer off the catch. He loves to spin in the lane as he attacks his defender. Maymon starts his attack with a powerful right-handed drive and spins back left as he goes by his defender and elevates for the shot. He rebounds on both ends with strength. At times, Maymon takes the ball out of the hands of opponents in order to gain possession. Maymon is a decent open-court ball handler, and he has the ability to draw and kick as he attacks from the high-post area. He must extend his shooting range; right now he plays more like an undersized power forward as opposed to a small forward. On defense, Maymon is alert and does a good job seeing man and ball. He also was very good anticipating passes, coming up with a couple steals. His toughness and competitiveness will make him a contributor at Marquette as a freshman.
Mike Bruesewitz PF (6-7, 215)
Senior, Mendota Heights, Minn. / Henry Sibley, Signed with Wisconsin
Bruesewitz is a tough, physical and skilled blue collar player. He can finish in transition after sprinting ahead of the opponents post defenders. Bruesewitz can handle the ball on the perimeter and is an excellent passer. He has great touch and a feel for where to put the ball; he can deliver it with either hand. Bruesewitz can make the open 3 with time and space and the midrange jumper off the catch and pull up off the dribble mostly going to his right. He finishes inside on a regular basis through contact from drop off passes created by guard penetration. He is athletic and smart enough to defend the 2, 3 or 4 positions; Bruesewitz understands how to utilize his length and keep a safe distance from a live dribble and still be able to keep good pressure on the ball. Bruesewitz must continue to work on his perimeter ball handling and more consistent shooter from beyond the arc but will fit in nicely at Wisconsin because of his ability to do a little bit of everything well and his aggressive style of play.
Sam Dower PF/C (6-9, 210)
Senior, Osseo, MN. / Osseo, Signed with Gonzaga
After sitting out the majority of the first half with two fouls dower got it going in the second half. He is a long and lean lefty that is a good athlete. He is very mobile and a quick jumper around the basket. Although he is still a work in progress on offense Dower has a couple go to moves that he executes very well. Dower likes to shoot the jump hook over his right shoulder on both sides of the lane but on the left side he will look to face up at times. He does a great job of sealing and resealing his defender to improve his post position. Dower is also a good passer out of the post vs. the double team. He get's the ball out of his hands right as he feels the pressure which makes it difficult for the defense to recover due too such quick ball movement. Dower can hit the mid range jumper with time to set and the trail three with time and space as well. His shot starts very low but ends with a good follow through. Added strength should help raise the starting point on his shot. Dower is a good rebounder especially on the offensive end as he uses his long wing span fore tip INS and to come over from the weak side to block shots. Defensively dower did a great job at helping in on ball screening situations. This young man has great upside.
Vander Blue SG (6-3, 185)
Junior, Madison, Wisc. / Memorial, Committed to Wisconsin
Blue is an athletic guard that is very quick off the dribble. He sprints the wing in transition and attacks the rim by beating the opponent with his speed. In the half court he can score quickly with his slashes in between defenders and drives along the baseline. He is thinking score all the way when he starts his attack. He seems to love to make his scoring moves from the right side of the floor. Blue can knock down the open three off the catch with time. He likes to shoot his threes from the low wing and corners. Blue is quick hands on ball defender and is big enough and a good enough athlete to defender both guard positions. Blue must learn to jump stop in the lane and kick the ball out to open teammates when he is attacking the lane because he is very charge prone. Overall a quick versatile guard that should be a nice fit at Wisconsin in the swing offense and in your face man defense.
Royce White PF/SF (6-6, 225)
Senior, Minnetonka, Minn. / Hopkins, Signed with Minnesota
White is a strong combination forward that plays more like a power forward than a small forward at this point. He is physical around the basket where on the left low block he likes to face and attack the rim along the baseline. White is strong enough to finish through contact when he get's his shoulders square to the basket. On the right low block he will also face and attack the middle of the lane and finish with his left hand over the defense. White loves to drive left when his faces up. White is an average shooter at best behind the arc and this is an area that he needs to develop along with adding some scoring drives off the dribble. But White can make an open three with time and space when he is in a scoring rhythm especially from the top of the key or corner. White is a good rebounder on both ends but could be better given his size and strength. He is a good passer on the move especially as he attacks with his right to left crossover. White is a capable multiple position defender that will learn how to stay in a defensive stance under head coach Tubby Smith when he arrives at cross-town Minnesota.
Surprise players
Junior Lomomba SG (6-4, 175)
Freshmen, Madison, Wisc. / Memorial
Lomomba is a strong wing that is still learning the game but has great upside. He runs the floor and attacks from the wing in transition and has no problem finishing through contact on a regular basis. He slashes and power drives into the lane most going to his right in order to get to the rim. He can make a wide open three when his feet are set but this is clearly an area that needs work because he is streaky at best. Lomomba is a fearless competitor for a freshman and plays with savvy, confidence and good energy. On defense Lomomba plays in a stance which is rare for players his age and has active hands when defending the ball. He is a capable multiple position defender because of his size and ability to move his feet. In the closing second of the game against Sibley Lomomba made scored on a drive that helped sealed the win for Memorial. Lomomba must continue to develop his total game and the sky is the limit on how good this future high major player can be.
Chris Halovorson PF/SF (6-8, 200)
Senior, Minneapolis/ Henry Sibley, Signed with Valparaiso
This long armed athletic forward sprint the floor and plays above the rim in transition. Halovorson can drive from the wing and high post area and attacks mostly to his right. He also scores on drop steps from the right low block and dunks drop off passes created by guard penetration. He has a decent mid range jumper off the catch but his perimeter shooting need to be much more consistent in or to play the small forward position for extended periods of time. He is great at finishing plays with his length and athletic ability. Halovorson is a good ball handler and decent passer on the move as well. He plays with toughness and urgency but needs to work on being a better defensive rebounder which should improve once he adds some much needed strength. Halovoron makes his presence felt on the offensive glass as he keeps the ball alive and score on a couple put backs. Halovorson has good upside and should be a solid contributor as a freshman at Valparaiso.
Rodney Williams SF (6-6, 185)
Senior, New Hope, Minn./ Robbinsdale Cooper, Signed with Minnesota
Williams is an extra long and lean athlete. He is off the charts athletic. Williams is an above the rim highlight in transition. Catching lobs is his specialty. Williams also scores with a one or two dribble pull up going to his right or a running floater where he uses his leaping ability and length to score over opponents. Skill development must be at the top of his list to be successful in college. Williams struggled to score in a half court setting. He must work on his overall shooting and ball handling. He didn't look comfortable shooting the three or making scoring moves off the dribble. He also had trouble finishing at times once he got to the rim because he seem to be anticipating contact instead of attacking the basket. Added strength will help him finish in the future. Williams sprints to the offensive glass on a regular basis attempting to time up a tip dunk but his lack of strength makes his easy to block out. He must also look to be a better defensive rebounder with his quickness and athletic ability. Defensively he works pretty hard and plays in a stance at times. Williams length and foot speed make him capable of defending all three perimeter positions. Williams has great upside but strength and skill lie between him being good or great.
Trent Lockett SG (6-5, 195)
Minnetonka, Minn. / Hopkins, Signed with Arizona State
Lockett is a strong shooting guard that is an excellent athlete. He has deep three point range off the catch and is a powerful above the rim finisher in transition with an explosive two foot vertical jump. He is very good at using the glass when he has a shot on the angle. Lockett has a quick and smooth release and shoots with confidence. He sprints the wing in transition and spots up along the arc daring his man to help on dribble penetration. In the half court he moves well without the ball and is good coming off screens ready to shoot. He will attempt to attack the basket mostly going to his right but that is clearly an area of concern. He must work on adding scoring moves off the dribble to his game to make him a complete scoring guard and become a better rebounder on both ends. Defensively Lockett plays with in a stance with urgency as he defends the ball. He also does a good job at helping defend on ball screens. Lockett will be an asset at Arizona State with his ability to stretch the defense with his shooting in their spread offensive attack.
Marvin Singleton SF (6-4, 200)
Sophomore, Minnetonka, Minn. / Hopkins
This big body wing attacks the rim in transition as well as in the half court. Singleton loves to work along the baseline and is plenty strong enough to finish once he gets to the rim. He can rebound on both ends and defensively he can start the break and has the ability to go coast to coast if the transition defense is not set. Singleton has a good mid range game. He can shoot 18 feet and in off the catch or dribble. Singleton does a good job reading dribble penetration and moving to the open area to receive the ball. He is also good at the catch and go move. Singleton does not waste time making a scoring move once he catches the ball especially if he identifies an opening or clear path to the rim. He power drives past defenders using his strong body. Singleton must continue to work on his all around skills especially working on extending his shooting range to the arc although he is a good ball handler and decent passer. On the defensive end singleton plays with toughness and emotion and is a good on ball defender. Singleton has great upside and one to watch as he develops.
Reggie Rankin is a recruiting coordinator for Scouts Inc. He was an assistant coach at seven schools for 13 seasons, most recently at Dayton. He played at Ohio University from 1986-1990 and was an all-MAC first teamer his senior season.


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We don't expect Florian Thauvin to be at Newcastle United too much longer, with the club trying to sell him this summer, and if Newcastle cannot do a permanent deal they will send him out on loan, as long as the loan club pays all of his wages.
It's a good question whether Florian will be reporting back to pre-season training this week, but Florian has revealed a little bit about what's going on and it seems his agent is in constant communication with Newcastle – and probably that's Rafa Benitez or maybe Lee Charnley.
Florian Thauvin – Newcastle have always been professional with me
Florian has been interviewed in Marseille newspaper La Provence today and he has addressed the rumors surrounding him:
"My agent has had discussions with Newcastle and is still doing so. Newcastle have always been professional with me."
"It's a legendary club in England who didn't deserve to go down. I felt for my teammates and the fans after they got relegated."
"That was hard for me. I know what I want. We're continuing talks with the club, but that stays between us. I respect Newcastle and those in charge too much to publicly discuss the situation."
"I know OM are thinking about it. As I've always said, Marseille will always mean something to me. Of course, you can't ignore their interest."
"It's up to Marseille or Newcastle to communicate on the matter. My agent is in talks with many clubs, but it's not up to me to say something."
"For now, I'm a Newcastle player."
That's about the level of detail Florian should be talking about with his current situation – not saying too much and leaving it to his agent,. Newcastle and other clubs to sort out his future.
It's good he's being respectful of Newcastle United and that shows some maturity and it's also in his best interests to act that way.
Comments welcome.


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Ham and Cheese Wraps
Be the first to review
READY IN: 20mins
Recipe by ARathkamp
This recipe is adapted from a Pampered Chef recipe out of their 2004 Spring / Summer "Season's Best" cookbook. The original recipe calls for iceburg lettuce, tomatoes and green bell peppers, but I have made some changes to adapt for our family's taste. This is a great base start and the combination possabilities are endless.
See Discussion:
Ingredients Nutrition
- 6 slices whole wheat sandwich wraps, I use Italian flavored or 6 slices flour tortillas
- 8 ounces fat free cream cheese
- 2 tablespoons Dijon mustard
- 1 tablespoon honey
- 2 cups fresh spinach leaves
- 12 slices ham
- 6 slices swiss cheese
- 12 slices bacon, pre-cooked strips
- 1⁄4 cup banana pepper ring (optional, also known as pepperochini's)
Directions See How It's Made
- Combine cream cheese, honey and mustard in a small bowl.
- Spread cream cheese mixture onto one side of each flat bread wrap.
- Add layer of spinach over cream cheese mixture, then layer of ham (2 slices per wrap). Press down firmly.
- Add layer of sliced swiss cheese (1 slice per wrap), then layer with bacon (2 slices per wrap).
- Add pepperochini's as an option.
- Roll each wrap, then cut diagonally with a serated (bread) knife.


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
JotForm Support
Unfortunately, for the Infinite List widget, the multi-language translation is not available.
But on some of the similar widgets like Dynamic fields and Matrix Dynamique you CAN type-in the translated text already.
You may want to try them instead.
Hope this help. Inform us if you need further assistance.


text:
为了使您在Abcam官网的浏览体验更顺畅,请使用最新版本的浏览器比如 Google Chrome
AREB6 recombinant fragment (Human)
Our Abpromise guarantee covers the use of ab53673 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Dot blot
|Use at an assay dependent dilution.
|Use at an assay dependent dilution. Predicted molecular weight: 124 kDa. Recombinant tested only.
ab53673 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"


text:
Welcome to mah epic quiz. No prizes, this is just for fun :)
Here's the rules:
- Easy questions are worth 1 point
- Medium Questions are worth 2 points
- Hard Questions are worth 3 points
- Expert Questions are worth 5 points
Ready, set, ANSWER!
Easy Questions
- How do you get the Golden Sunflower Trophy?
- Can you plant Flower Pots on Lily Pads?
- What minigame replaces Big Trouble Little Zombie in the DS version?
- How many seed slots do you have at the begginning of the game?
- What is the only plant with diferrent color petals?
- What are the tallest plants?
- Can Bungee Zombie steal Cob Cannon?
- List all plants that cannot be imitated
- List all of the upgrades
- List all of the defesive plants
Medium Questions
Coming soon!
Hard Questions
Coming soon!
Expert Questions
Coming soon!
Answer all easy questions until June 8th, 2012!!! Because it's the time for counting corrects and wrong!!!
On June 10th, 2012, it's time to answer the medium questions.


text:
Dr. Mauricio Marcos received his medical degree from the Universidad Autonoma de Nuevo Leon. He completed residency at Hospital San Jose Tec of Monterrey and his fellowship in both Rio de Janeiro and Parana, Brazil, studying plastic surgery under the legendary surgeon Dr. Ivo Pitanguy. Dr. Marcos has 14 years of experience and his practice offers all types of cosmetic surgeries and body contouring procedures in Monterrey, Mexico and Brazil.
He is Board Certified by the Mexican Association of Aesthetic, Plastic and Reconstructive Surgery, and an active member of the Brazilian Society of Aesthetic Plastic Surgery, and International Society of Aesthetic Plastic Surgery.
Education and Training
- Medical Degree 1984 – Universidad Autonoma de Nuevo Leon
- Brazilian Society o Aesthetic Plastic Surgery
- Internship – 1984 – Hospital Universitario de Monterrey
- General Surgery 1990 -Hospital San Jose TEC de Monterrey
- Plastic and Reconstructive Surgery 1994 – Instituto Jalisciense de Cirugía Reconstructiva
- Clínica Pitanguy, Botafogo, Río de Jainero, Brazil
- Hospital de Ipanema, Ipanema, Río de Janeiro, Brazil
- Hospital Santa Casa, Curitiba, Parana, Brazil
Professional Associations / Affiliations
- The Mexican Association of Plastic, Aesthetic and Reconstructive Surgery A.C
- Brazilian Society off Aesthetic Plastic Surgery
- International Society Of Aesthetic Plastic Surgery (ISAPS)
- License to practice in Mexico # 1102281
Clinical Interests
- Abdominoplasty
- Brachioplasty (Arm Lift)
- Brazilian Butt Lift
- Breast Augmentation
- Buttock Augmentation
- Liposuction
- Upper Body Lift
Submit free quote request on right for considering surgery by Dr. Mauricio Marcos and other world class doctors.


text:
Chemical: Drug
Available Prescribing Info
- Annotation of CPIC Guideline for abacavir and HLA-B
- Annotation of DPWG Guideline for abacavir and HLA-B
1. Annotation of CPIC Guideline for abacavir and HLA-B
In individuals with the HLA-B*57:01 variant allele ("HLA-B*57:01-positive"), abacavir is not recommended and should be considered only under exceptional circumstances. See full guideline for disclaimers, further details and supporting evidence.
This annotation is based on the CPIC® guideline for abacavir and HLA-B.
May 2014
Accepted article preview online 21 February 2014; Advance online publication 12 March 2014
The 2014 update of CPIC guidelines regarding abacavir has been published in Clinical Pharmacology and Therapeutics. Literature published between April 2011-November 2013 was reviewed and there is no new evidence that would change the original guidelines. Therefore, the dosing recommendations in the original publication remain clinically current.
- These guidelines are applicable to:
- HIV Patients
- Download and read:
April 2012
Advance online publication February 2012
- Download and read:
Excerpt from the abacavir dosing guidelines:
We agree with others* that HLA-B*57:01 screening should be performed in all abacavir-naive individuals before initiation of abacavir-containing therapy (see Table 1 below); this is consistent with the recommendations of the FDA, the US Department of Health and Human Services, and the European Medicines Agency. In abacavir-naive individuals who are HLA-B*57:01-positive, abacavir is not recommended and should be considered only under exceptional circumstances when the potential benefit, based on resistance patterns and treatment history, outweighs the risk.
*[Articles:18826546, 19640227, 21174626, 21412232] Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents (PDF)
Table 1: Recommended therapeutic use of abacavir based on HLA-B genotype
Adapted from Tables 1 and 2 of the 2012 guideline manuscript.
|Likely phenotype
|Examples of diplotypes
|Implications for phenotypic measures
|Recommendations for abacavir therapy
|Classification of recommendation for abacavir therapy a
|Very low risk of hypersensitivity (constitutes ~94% b of patients)
|Absence of *57:01 alleles (reported as "negative" on a genotyping test)
|*X/*X c
|Low or reduced risk of abacavir hypersensitivity
|Use abacavir per standard dosing guidelines
|High risk of hypersensitivity (~6% of patients)
|Presence of at least one *57:01 allele (reported as "positive" on a genotyping test)
|*57:01/*X c *57:01/*57:01
|Significantly increased risk of abacavir hypersensitivity
|Abacavir is not recommended
a Rating scheme described in the 2012 Supplement
b See the 2012 Supplement for estimates of genotype frequencies among different ethnic/geographic groups
c *X = any HLA-B genotype other than *57:01.
HLA-B = human leukocyte antigen B
Listen to an interview with the lead author: podcast
2. Annotation of DPWG Guideline for abacavir and HLA-B
An alternate to abacavir should be selected for patients who have the HLA-B*57:01 allele (patients who are "HLA-B*57:01-positive").
The Royal Dutch Pharmacists Association - Pharmacogenetics Working Group has evaluated therapeutic dose recommendations for abacavir based on HLA-B*57:01 [Article:21412232]. They conclude that an alternate drug should be selected for patients who are HLA-B*57:01 positive.
|Therapeutic Dose Recommendation
|Level of Evidence
|Clinical Relevance
|Select alternative drug
|Published controlled studies of good quality* relating to phenotyped and/or genotyped patients or healthy volunteers, and having relevant pharmacokinetic or clinical endpoints.
|Clinical effect (S): Failure of lifesaving therapy e.g. anticipated myelosuppression; prevention of breast cancer relapse; arrhythmia; neutropenia < 0.5x109/l; leucopenia < 1.0x109/l; thrombocytopenia < 25x109/l; life-threatening complications from diarrhea.
Annotated Labels
- Annotation of FDA Label for abacavir and HLA-B
- Annotation of EMA Label for abacavir and HLA-B
- Annotation of PMDA Label for abacavir and HLA-B
- Annotation of HCSC Label for abacavir and HLA-B
1. Annotation of FDA Label for abacavir and HLA-B
The FDA-approved label for abacavir states that genetic testing for the HLA-B*5701 allele is required prior to initiating or reinitiating treatment with abacavir in patients of unknown HLA-B*5701 status. Abacavir is contraindicated in patients with the HLA-B*5701 allele due to risk for abacavir hypersensitivity reactions.
There's more of this label. Read more.
2. Annotation of EMA Label for abacavir and HLA-B
The EMA European Public Assessment Report (EPAR) states screening for the HLA-B*5701 allele should be carried out prior to initiating abacavir treatment and recommends screening in patients of unknown HLA-B*5701 allele status who are reinitiating treatment with abacavir. Due to a high risk of hypersensitivity reaction abacavir is not recommended in individuals carrying this allele.
There's more of this label. Read more.
3. Annotation of PMDA Label for abacavir and HLA-B
The HLA-B*57:01 allele is associated with a high risk of experiencing a hypersensitivity reaction to abacavir in multiple populations, including Caucasians and African-Americans. However, the PMDA package insert for abacavir notes that the association between HLA-B*57:01 and risk of an abacavir hypersensitivity reaction is unknown in Japanese patients, and that the *57:01 allele has a reported prevalence of only 0.1% in the Japanese population.
There's more of this label. Read more.
4. Annotation of HCSC Label for abacavir and HLA-B
The product monograph for abacavir (ZIAGEN) states that all patients should be screened for the HLA-B*5701 allele prior to initiating or re-initiating treatment with abacavir, due to the high risk of experiencing a hypersensitivity reaction (HSR) for patients carrying this allele.
There's more of this label. Read more.
Clinical Variants that meet the highest level of criteria, manually curated by PharmGKB, are shown below.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.
Clinical Annotation for HLA-B*57:01:01, abacavir and Drug Hypersensitivity (level 1A Toxicity/ADR)
- Type
- Toxicity/ADR
- Variant
- *57:01:01
- Genes
- Phenotypes
- Drug Hypersensitivity
- OMB Race
- Unknown
Clinical Annotation for rs3093726 (LST1, LTA, LTB), abacavir and Drug Hypersensitivity (level 4 Toxicity/ADR)
- Type
- Toxicity/ADR
- Variant
- rs3093726
- Genes
- Phenotypes
- Drug Hypersensitivity
- OMB Race
- Asian
- Race Notes
- Han Chinese
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Gene" column lead to PharmGKB Gene Pages.
List of all variant annotations for abacavir
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
[ close ]
|Gene ?
|Alternate Names ?
|Chemicals ?
(+ chr strand)
|Function ?
Amino Acid?
|NC_000006.11:g.31546789T=, NC_000006.11:g.31546789T>C, NC_000006.12:g.31579012T=, NC_000006.12:g.31579012T>C, NG_007462.1:g.8440T=, NG_007462.1:g.8440T>C, NT_113891.2:g.3056405T=, NT_113891.2:g.3056405T>C, NT_113891.3:g.3056299T=, NT_113891.3:g.3056299T>C, NT_167244.1:g.2861507T=, NT_167244.1:g.2861507T>C, NT_167244.2:g.2911591T=, NT_167244.2:g.2911591T>C, NT_167245.1:g.2832330C=, NT_167245.1:g.2832330C>T, NT_167245.2:g.2826745C=, NT_167245.2:g.2826745C>T, NT_167246.1:g.2889673T=, NT_167246.1:g.2889673T>C, NT_167246.2:g.2884053T=, NT_167246.2:g.2884053T>C, NT_167247.1:g.2926495T=, NT_167247.1:g.2926495T>C, NT_167247.2:g.2920910T=, NT_167247.2:g.2920910T>C, NT_167248.1:g.2840429T=, NT_167248.1:g.2840429T>C, NT_167248.2:g.2834833T=, NT_167248.2:g.2834833T>C, NT_167249.1:g.2877590T=, NT_167249.1:g.2877590T>C, NT_167249.2:g.2878292T=, NT_167249.2:g.2878292T>C, rs146565584, rs7764269
- abacavir
- Epzicom
- Ziagen
- Kivexa (Abacavir Sulfate + Lamivudine)
- Trizivir (Abacavir Sulfate + Lamivudine + Zidovudine)
PharmGKB Accession Id
Source: Drug Bank
Source: Drug Bank
Other Vocabularies
Information pulled from DrugBank has not been reviewed by PharmGKB.
Pharmacology, Interactions, and Contraindications
Mechanism of Action
Source: Drug Bank
Source: Drug Bank
Food Interaction
Source: Drug Bank
Absorption, Distribution, Metabolism, Elimination & Toxicity
Source: Drug Bank
Source: Drug Bank
Route of Elimination
Source: Drug Bank
Chemical Properties
Source: PubChem
InChI String
Source: PubChem
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
Schematic representation of abacavir metabolism and mechanism of action. The potential mechanism of an abacavir hypersensitivity reaction is also shown.
Publications related to abacavir: 74
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
[ close ]
- Web Resource:
- Wikipedia
- National Drug Code Directory:
- 0173-0661-01
- DrugBank:
- Chemical Abstracts Service:
- 188062-50-2
- PubChem Substance:
- 46505718
- Drugs Product Database (DPD):
- 2240358
- ChemSpider:
- 58649
- Therapeutic Targets Database:
- FDA Drug Label at DailyMed:
- 6a3b10fc-4b2a-45e3-16a1-ef79187a6dfb
Clinical Trials
These are trials that mention abacavir and are related to either pharmacogenetics or pharmacogenomics.
NURSA Datasets
No NURSA datasets available.


text:
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text:
Island caught in the grip of gambling
JERSEY has more than double the number of bookmakers compared with places of a similar size in the UK, the JEP can reveal at the start of a special series into gambling.
JERSEY has more than double the number of bookmakers compared with places of a similar size in the UK, the JEP can reveal at the start of a special series into gambling.
There are 29 licensed bookmakers in the Island, compared with up to 12 for areas with a population of 100,000 in the UK.
In the UK, bookmakers are more common in the most deprived areas, which have up to 12 per 100,000 people, compared to rich areas which have as few as five. By contrast, affluent Jersey has more than twice as many as the poorest parts of the UK.
One Jersey gambler – who estimates that he has lost the value of a house over a life-time of gambling – says that gambling addiction in Jersey is a bigger problem than people realise and that the number of people getting help at Jersey Gamblers Anonymous is just 'the tip of the iceberg'.
• See today's JEP for his storySubscribe to our Newsletter
Comments for: "Island caught in the grip of gambling"
Conversation between my Irish Grandmother and me before she died:
Gran : Now there's a lot of gambling in Jersey, promise me you won't waste your money on it [Renegade], it's a mug's game.
Me : Gran the only time I've ever set foot in a Bookie's in my life was to collect YOUR winnings on the Grand National.
Gran : Oh well, that's alright then....
etc. etc.
Imagine the money you'd make out of a casino!
Too glamorous for Jersey !
Can't even play Lotto/ Euro million. We are doomed with those grubby Ladbrokes , crap lotteries who don't even deliver.
Fair enough it s helping local charities but those gambling place are aiming at the less fortunate. I ll be curious to know how much welfare money s been spent in there.
At least casino will target more of the one who can afford it.
Oh Boy, shock horror is this really news? We also have twice the number of petrol stations when compared to a similar size village in the UK. Also twice the number of cafes, pubs ,restaurants, taxis / cabs, chemists, you name it we have more when compared of just about everything.
Is this really a news story? Or just stating the blooding obvious.
Exactly what I was going to say. The reason we have so many of everything per head of population is that Jersey has or had a much higher disposable income per head, and all businesses in Jersey made much higher profit margins than the UK.
Higher proportion of civil servants when compared to a city with a population 10 times ours.
Don't worry though, the Methodists will sort out our gambling problems, just as they have done with drinking, smoking etc.....
Soon we'll all be sitting at home, reading the bible by candle light
JERSEY has more than double the number of everything compared with places of a similar size in the UK
Apart from decent supermarkets to generate a bit of competition and bring prices down!
Yes, and just about double the price of everything in the UK
Well, that's because we have nothing else to do here. You can't just get in your car and go to a different town and spending the whole winter in a tiny damp flat just makes people drink or gamble. It's actually quite sad when you think about it + even the UK has a high amount of gambling compared to the rest of Europe.
They could go and live somewhere else ..
How can they go somewhere else if they don't have money, it's an addiction.
ah your usual reply
this may come as a shock to you but not all jersey born natives have the sun shining out of their proverbial as you seem to think.
Some of them do have flaws in their character - i am sorry to break this distressing news to you but there you go.
Local girl
And this is news to who ? Having been married to a chronic gambler I did find it a little tricky to find any support, I was directed through the AA. Over the space of a few years he lost approximately 50k of my money and plenty more of other peoples money.
The bookies left I until it got to a ridiculous level until eventually he was banned from a few of them. It is a totally destructive addiction.
Old Crappo
all I can say is so what, if we didn't have these bookie shops then there would be even more unemployed people then there already are. And don't forget that even if we didn't have any bookies shops in the Island at all then people would simply gamble online and there is nothing anyone can do about that!
Don't forget more alcoholics, more drug addicts, more suicides, more heart problems, more cancer, bigger obesity, bigger police force, the list is endless
And what do the SOJ do, allow them to open on Sundays. Says it all really, bunch of idiots not in touch with the people they,re supposed to be representing! Tell you another thing, look at the volume of businesses advertising in Yellow pages in Jerset compared to Guernsey. Whats that all about, obviously businesses here make a bigger return than our sister island otherwise it wouldn,t be able to sustain the higher number.
Stupid article, we've got more of everything here. Also, the true gambling problems are now online, not with high street bookies
Its not so much the number of bookies but the number of FOBTs which are the problem. There are many people hooked on them and this problem is getting worse all the time
FOBT' (Fixed Odds Betting Machines), described recently in the UK Media as the CracK Cocaine of gambling.
I would imagine a lot of IS claimants have a lot of time on their hands to do this, its not as though they will put money back if they should win, uhmmmmm, I wonder if IS have checked this area out for fraud, extra undeclared income??
the thin wallet
why go to the bookies shop , you can gamble online from home or you seat in the pub if its got wifi.
lets not forget the stockmarket you can gamble on that too.
you do not see the job in the bookies advertised as they( i believe) are not allowed to. so if you are local and want a job why not pop in to one and see if they have any jobs , you never know. even better if you like horses and sport .
And this story gets published on the same night as our new expensive gambling commission announces that it want to raise money through compulsory permit fees to our pubs.
Just more Civil Service spin to justify their gravy train.
Fed Up
Bookmakers only want one thing FOBT (fixed odds betting terminals of fruit machines). They cannot lose and that is what people get addicted to most.
I think those statistics will change shortly if the UK goverment allows more bookmakers to open on the UK High Street.
What about those who gambled and lost on the stock market but got their money back thanks to us taxpayers courtesy of Ozouf. Now THAT is the way to gamble!!
And this story gets published when two long standing retailers are closing down. Bookies in deprived areas? Says it all really. You don't have to have a high IQ to think about any bookies that have closed down
More money waisted get a grip loads go online and machines are a big problem but thats gambling ,drink, drugs where does it end big brother wants a slice.
As has been pointed out numerous times above, if people want to gamble they'll gamble online or at the bookies. There is NO good reason why Jersey shouldn't have a high quality casino that can be regulated and taxed. Its a win for the states in terms of tax receipts, more employment and more visitors to the Island.
I still don't understand these politicians that vote against it when it comes up for debate every 5 years or so as they obviously don't mind us gambling as there are no restrictions to online gambling and no restrictions to the amount of bookies in the Island.
Its a sad fact that some people do become addicted to gambling, similarly to those that get addicted to drugs, alcohol etc. That unfortunately is a fact of life, you can't make laws for the minority, they should be made for the majority.
Parktown Prawn
So true.......I don't understand the taboo of having a casino in Jersey.
There are plenty of alcoholics here and yet pubs and supermarkets are still open to trade booze....every day of the week.
There are plenty of drug abusers here and yet their illegal addiction is still available for them to use regularly.
There are plenty of gamblers already going online.....and if there was no internet they would do it "underground". I've heard of many high stakes poker games which used to take place in Jersey before the online poker boom. I wouldn't be surprised if some of our illustrious "decision makers" were involved in some of these games themselves ;-)
Think they should allow a casino in this Island,certainly make some revenue thats being lost
Parktown Prawn
....and it could encourage tourism.


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2 Min Read
April 2 (Reuters) - The Ohio Turnpike Commission will sell up to $1 billion of revenue bonds this summer, an official said on Tuesday.
Rick Hodges, the turnpike's executive director, said the commission will pick underwriters for the negotiated deal at its meeting next week.
Ohio Governor John Kasich signed into law on Monday a bill authorizing the sale of $1.5 billion of bonds backed by turnpike revenue along with the state's two-year transportation budget.
Hodges said the remaining $500 million of bonds would be sold in three to four years. Proceeds from the bonds will fund transportation projects related to and within 75 miles of the turnpike, he added.
Kasich unveiled a plan to tap excess turnpike revenue for the bonds in December after he rejected the option of leasing the 241-mile toll road to a private entity.
Fitch Ratings said in January that the plan was not expected to negatively impact the turnpike's AA-rated outstanding debt.
Under the new law, the Turnpike Commission will have expanded authority and a new name - the Ohio Turnpike and Infrastructure Commission, effective July 1.


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Announcing our 2017-2018 Season
4/13 - 4/18: Renewals for current season subscribers*, and MEMBERS (Aria Circle and up). *Current subscribers may retain their seats for next season as long as they renew during this period. Subscribers will receive renewal information via email on 4/13.
4/19: Season Subscriptions AND tickets for June 8th Season Preview Party on sale to General Public
6/15: MEMBERS (Aria Circle and up) access to Single Tickets and Sampler Packages
7/1: Single Tickets and Sampler Packages go on sale to General Public
Baltimore Concert Opera welcomes everyone to experience timeless music and stories which bring us together.
Discover our up close and personal operatic format -- spectacular singers, piano, and projected English translations, just a few feet from your seat in the gilded ballroom of the Engineers Club in Mount Vernon, Baltimore.
Treat yourself to the unfiltered beauty of the human voice.


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Имя материала: Лексикология английского языка
Автор: Антрушина Галина Борисовна
In this book the reader will find the fundamentals of the word theory and of the main problems associated with English vocabulary, its characteristics and subdivisions. Each chapter contains both theory and exercises for seminar and independent work.
The book is intended for English language students at Pedagogical Universities (3d and 4th years of studies) taking the course of English lexicology and fully meets the requirements of the programme in the subject. It may also be of interest to all readers, whose command of English is sufficient to enable them to read texts of average difficulty and who would like to gain some information about the vocabulary resources of Modern English (for example, about synonyms and antonyms), about the stylistic peculiarities of English vocabulary, about the complex nature of the word's meaning and the modern methods of its investigation, about English idioms, about those changes that English vocabulary underwent in its historical development and about some other aspects of English lexicology. One can hardly acquire a perfect command of English without having knowledge of all these things, for a perfect command of a language implies the conscious approach to the language's resources and at least a partial understanding of the "inner mechanism" which makes the huge language system work.
This book is the first attempt to embrace both the theory and practical exercises in the one volume, the two parts being integrated. The authors tried to establish links between the theory of lexicology and the reality of living speech, on the one hand, and the language-learning and language-teaching process, on the other, never losing sight of the fact that the majority of intended readers of the book are teachers and students of Pedagogical Universities.
The authors tried to present the material in an easy and comprehensible style and, at the same time, to meet the reader on the level of a half-informal talk. With the view of making the book more vivid and interesting, we have introduced extracts from humorous authors, numerous jokes and anecdotes and extracts from books by outstanding writers, aiming to show how different lexicological phenomena are used for stylistic purposes.
Theory and exercises to Ch. 1—2 were written by G. B. Antrushina, exercises to Introduction and Ch. 5, 6, 9, 10,11 by 0. V. Afanasyeva and to Ch. 3, 4, 7, 8,12,13,14 by N. N. Morozova.
The authors wish to acknowledge the considerable assistance afforded them by their English colleague Mr. Robert T. Pullin, Lecturer in Education, Russian and French, at the University of Sheffield, U. K., who kindly acted as stylistic editor before final publication.
We are also sincerely grateful to our colleagues at the Pyatigorsk and Irkutsk Institutes of Foreign Languages and at the Pedagogical Institute of Ekaterinburgh who read the book in manuscript and made valuable suggestions.


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text: Dumpamir Gender: Male Height: Shorter than Phineas Nationality: Possibly American Friends and Family Behind the Scenes First Appearance: "Lost in Danville" Last Appearance: "Lost in Danville" Voiced by: Jeff "Swampy" Marsh Dumpamir is a small man that appeared in "Lost in Danville" Appearences "Lost in Danville " Retrieved from "http://phineasandferb.wikia.com/wiki/Dumpamir?oldid=623556" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Characters Adults Males D One appearance only


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Admire the most beautiful places of Galatina and add them to your basket. YAMGU will create your trip considering distances, opening hours and weather.
The museum - which was once housed in the current city hall - is located in a wing of the first floor of the former Dominican monastery which is now the Palace of Culture "Zeffirino Rizzelli", which also houses the library and the 'historical municipal archive. The birth of the museum, already advocated in 1913 by the scholar Cosimo De Giorgi, was due to the initiative of Francesco Bardoscia, secretary of the local section of the PNF. The collection was inaugurated in 1936 in the first place with the exhibition of antiquities and works of local heritage. The main collections are essentially tw


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SUB - Subtitle File - is an extension used with MicroDVD, DivX, and a few other programs. It is a text file that can hold information about text documents, subtitle text, and cue points telling the program when to show the subtitles. It is usually found in conjunction with the corresponding video file. It might even be referenced as the video file is playing back.
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User Reviews


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|1,600 sq. ft.
|Property type
|Minimum Stay
|3 - 7 nights
Beautiful waterfront house is a perfect get-away for family fun and offers over 100 feet of direct lake frontage on a level lot including a private sandy beach area, dock and swim raft. Enjoy relaxing days spent lounging on the beach or take a paddle around the lake in the canoe or one of our kayaks. The kids can take the paddleboat out for a spin and enjoy exploring the sand bar located within swimming distance of the beach. There is also a row boat, horseshoes and a large grassy area for lawn games. My son has named this property Lakeshire as a nod to the Hobbit and the peaceful nature of the Shire.
Each season brings a new way to enjoy this home. There are opportunities for swimming, fishing, kayaking, biking, fall foliage, hiking and much more! The lake has no public boat launch which keeps boat traffic to a minimum. We are located at the north end of the lake providing views of both sunrise and sunset and sun all day long.
This inviting waterfront retreat offers an open floor plan for the first floor with a beautiful view of the lake, three bedrooms and two full baths. The first floor has sliding doors that open to the deck area with outdoor table and chairs. The living room area has a TV and VCR/DVD player and a selection of movies, or bring your own. Enjoy peaceful dinners with lake views in the dining area that seats 6 comfortably or outside on the deck. Kitchen area has counter bar with seating for 3. Upstairs bedrooms sleeps 8 comfortably. The master suite overlooks the lake with a comfortable queen size bed and bathroom has a large closet and a shower and tub. The second bedroom has a queen sized bed and the third bedroom has a set of bunk beds and an additional queen bed.
Outside, there is a gazebo to sit in the shade while watching the kids play on the beach or play badminton. The large sandy beach area is perfect for building sandcastles or playing horseshoes or just hanging out. The beach has a gradual entry into the water that is perfect for children, and the older kids love the swim raft. A fire pit beckons for nighttime fun roasting marshmallows or making S'mores by the water's edge. The property sits on a generous 1 acre lot with an inlet on one side so there are lovely water views and plenty of space.
Air conditioning is rarely needed, but there is a wall unit in the master bedroom and the living room. There is no phone landline at the house, and cell service can be spotty, but we have wireless high speed internet (bring your own computer/wireless device).
For a little exercise and a 100 mile view, climb Mt Monadnock, the most climbed mountain in the world according to Wikipedia and only about 30 minutes from the house. Horses and trail rides are also about 30 minutes away. Enjoy the peace and tranquility of Cathedral of the Pines, 15 miles away. We are 10 minutes to Mt Watatic and The Mid State Trail (hiking), 30 minutes to Wachusett Mountain, which offers hiking, biking, chairlift rides to the summit. This is a rural area but nearby towns such as Gardner or Leominster, MA, and Keene or Peterborough, NH are 30 minutes away for movies, bowling, plays, museums, etc. For some family fun, try Davis' Farmland and MegaMaze, 45 minutes from the property which has amusements for younger kids through teenagers. Want an adventure for adults? The oldest commercial skydiving center, Jumptown, is located 45 minutes away in Orange, MA. Or just stay at the lakehouse and relax! We are 90 minutes outside of Boston, 2 hrs. from Hartford. Located near Cushing Academy.
This is a great place for a fun and relaxing get-away any time of the year! Feel free to email with any questions--please leave your phone number so I can return calls--I've had some difficulties with my email responses getting through.
Rita's home was absolutely beautiful, our stay for the weekend was lovely and conveniently located just a short drive from Wachusset Mountain. The house was so comfortable and full of light with wonderful views of the water to enjoy from the comfy couches in the open plan kitchen/living room.
Would definitely stay again in a heartbeat!
My husband and I stayed for a few days while visiting our son at Cushing. Was very convenient to school, there within 10 minutes. The lake was frozen, but the house has skates if you want to skate. The owners made sure the driveway was plowed when it snowed. The house is very comfortable, warm, extremely clean and has everything you need in kitchem. We always have trouble with cell service when in the area, but the wifi worked great and my husband was able to work in the mornings. Could not ask for anything else.
The week we stayed at this open, spacious lakefront house was perfect. Our four kids (12, 10, 8, and 9 months) all had a blast. The lake is private and quiet (even those weekend days). The fishing was great, 4 large mouth bass were caught along with some large perch and sunfish. The owner touched base with us prior to the visit to answer all our questions. We highly recommend this beautiful house.
This was a great place to stay... I had both family time and some time to myself. It was almost like having the lake to ourselves .. great fun to paddle but I really enjoyed just a float too. Just down the road is a short hike up Mt Watatic which has a fabulous view of the area.
The house is comfortable feeling... Just like a second home. Nothing is old and broken nor is anything so new looking that you're afraid to use it. It really does have the comforts of home ;)
We spent a wonderful 2 weeks here with family including 2 - 6 year olds. The private beach has a gentle slope and visibility from the house and porch made monitoring them in the water easy, although we spent most of the time in the water with them.
The house is clean and modern, more of a lake house than a cabin in the woods. What a view from the deck and windows of this place.
My wife, son and I enjoyed our stay at Lakeshire. The owners were a pleasure to deal with and the house was super clean and spacious. We enjoyed fishing daily and were super happy reeling in fish after fish. At night we enjoyed S'mores and a nice warm fire on the beach right out our back door. We will definitely return in the future and highly recommend this rental.
|Rate Period
|Weekend Night
Summer 2017
May 26 2017 - Sep 15 2017
Changeover Day: Friday
7 night minimum stay
My Standard Rate
3 night minimum stay
|Refundable damage deposit
|Property Damage Protection
|Cleaning fee
Rates are subject to change until reservation is confirmed. A maximum of 8 people are allowed on the property at any one time and all must be listed on the rental agreement. This restriction is due to the septic system limitations. Guests not abiding by this rule will automatically forfeit their security deposit.


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Mouth / Buccal Cavity
The mouth, or buccal cavity, and its extension, which stretches through the body to the anus, is not listed as an internal body cavity. Why?
Solution Preview
Because technically, it's not "internal" to the body. It's "external" to the ...
Solution Summary
This solution explains why the buccal cavity is not considered internal.


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For a while now, Dilly Duka has been looking for a fresh start.
The midfielder could see the writing on the wall last season when he lost his starting spot at the Columbus Crew with five games remaining in 2012.
"I personally felt that I was too complacent and a little too content in that atmosphere," Duka told MLSsoccer.com by phone on Tuesday. "I just needed a new environment to rekindle my drive and go forward."
READ: Crew get fastest man in MLS in Duka trade
With the Chicago Fire trading for him on Monday, Duka now has a chance to reboot a career that has been filled with promise, but devoid of significant production.
The 23-year-old was poised for a breakout season in 2012 after an offseason training with the Generation adidas team and the United States Under-23 national team ahead of the Olympic qualifying tournament. But 12 minutes into that first qualifier, Duka tore his hamstring, which sidelined him for the better part of the next three months.
"It was a lesson well-learned," Duka said. "Now I know that in the offseason, you need to be off for a good amount of time."
WATCH: Duka on Fire vs. Crew rivalry
Duka regained his starting spot with the Crew in July, starting 11 of the club's next 12 games. But after taking time away from the team in September, the third-year midfielder started on the bench for the last five games of the season.
He first heard of the Fire's interest in December, and he knew a deal was close when he met with the club's front office and coaching staff last week.
Chicago were cautious with their vetting process, and coach Frank Klopas said the club isn't worried about Duka's character after the apparent falling-out in Columbus.
"I found that the kid is a stand-up guy, he's got a lot of character, he works very hard, and a lot of times things happen and things get blown out of proportion," Klopas said on a conference call from Ventura, Calif., this week. "We don't know what really happened there. You read stuff in the paper, but I've talked to the kid many times. I think he's looking forward to being part of this organization, and really have an impact being the player based on the talent he has."
READ: Five things to know about Dilly Duka
The Fire were in need of another outside midfielder after Álvaro Fernández's departure this offseason, and Duka has a chance to slide right into the Uruguayan's spot on the left side.
Duka never reported to preseason with the Crew, so he's working his way into shape after meeting up with the Fire in Southern California this past weekend for the club's second phase of preseason.
After a busy offseason put too much strain on his body last year, the extra rest was welcome. Now, he's focused on rejuvenating his young career.
"This offseason, I took a good amount of time off, and I'm healthy as we speak," Duka said. "I was just excited that [the trade] happened now rather than later, so I actually get to come to preseason with a team."
Anthony Zilis covers the Chicago Fire for MLSsoccer.com


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©2005-2017 TheTopTens® All rights reserved.
Best Actors Born In the '60sdanielst20
The Top Ten
1 Johnny Depp John Christopher "Johnny" Depp II is an American actor, producer, and musician. He has won the Golden Globe Award and Screen Actors Guild Award for Best Actor. His role in a movie is often rather big. His character is often on the "loopy side" and his character being in a darker state of mind, etc.
2 Robert Downey Jr. Robert John Downey Jr. is an American actor. His career has included critical and popular success in his youth, followed by a period of substance abuse and legal troubles, and a resurgence of commercial success in middle age.
3 Sean Penn Sean Justin Penn is an American actor, filmmaker, and political activist. He has won two Academy Awards, for his roles in the mystery drama Mystic River and the biopic Milk.
4 Philip Seymour Hoffman
5 Djimon Hounsou
6 Benicio Del Toro
7 Hugh Jackman Hugh Michael Jackman is an Australian actor, producer and musician . Jackman has won international recognition for his roles in major films, notably as superhero, period, and romance characters .
8 Brad Pitt William Bradley "Brad" Pitt (born December 18, 1963) is an American actor and producer. He has received a Golden Globe Award, a Screen Actors Guild Award, and three Academy Award nominations in acting categories and received three further Academy Award nominations, winning one, as producer under his ...read more.
9 Matthew McConaughey Matthew David McConaughey is an American actor and producer. He first gained notice for his breakout role in the coming-of-age comedy Dazed and Confused, and went on to appear in films such as the slasher Texas Chainsaw Massacre: The Next Generation, the legal thriller A Time to Kill, Steven Spielberg's ...read more.
10 George Clooney George Timothy Clooney is an American actor, filmmaker and activist. He has received three Golden Globe Awards for his work as an actor and two Academy Awards, one for acting and the other for producing.
The Contenders
11 Javier Bardem
12 Ralph Fiennes
13 Tom Cruise Tom Cruise is an American actor and filmmaker. Cruise has been nominated for three Academy Awards and has won three Golden Globe Awards.
14 Nicolas Cage Nicolas Kim Coppola, known professionally as Nicolas Cage, is an American actor and producer. He is well known for his roles in Raising Arizona, Moonstruck, Vampire's Kiss, Wild at Heart, Honeymoon in Vegas, Red Rock West, Leaving Las Vegas, The Rock, Con Air, Face/Off, City of Angels, 8MM, Bringing ...read more.
15 Mark Ruffalo
16 John C. Reilly
17 Woody Harrelson
18 Russell Crowe Russell Ira Crowe is an actor, film producer and musician. Although a New Zealand citizen, he has lived most of his life in Australia and identifies himself as an Australian.
19 Salman Khan
20 Jeremy Clarkson Jeremy Charles Robert Clarkson is an English broadcaster, journalist and writer who specialises in motoring.
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2. Johnny Depp
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Drag On
In the Nineties heyday, no respectable South Beach club was without its queens statuesque bombshells taking on bouncer duties at the door, bumping and grinding on the dance floor, posing for photographs, or generally showing up and being showered with drink tickets just for being so effing fabulous. The scene has lost much of its luster, but thankfully some nightspots still recognize the instant allure a colorful collective of queens can bring. Few parties celebrate Miami drag royalty quite like Click Sunday at Aero Bar. The formula is simple: Take a handful of Miamis HBICs Elaine Lancaster, Adora, Chyna Girl, and Misty Eyes, for example add a handful of celebrity DJs and a smattering of quirky local celebrities (Mickey Rourke, anyone?) and there you have it. The brainchild of Omar Gonzalez and Dustin Reffca has switched venues more times than a showgirl changes wigs. Still, Click keeps on packing in crowds of gay, straight, and whatever-were-here-to-party people, Sunday after Sunday. Maybe its time you found out why.
Sundays, 10 p.m., 2008
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From the full time music ring sounds were first introduced by cell phone manufacturers, the marketplace made an instantaneous sales that reaches huge amount of money. Talk about making a runaway hit. With individuals who just love playing their songs, it is no wonder why everybody want them as their ring tone.
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What are the forms of music ring tones as possible have on your own cellular phone?
1. Monophonic ring tone.
Monophonic ring tone is when melody could be the just one that is being played. This is done one note at a particular time. Monophonic ring tones do not have equilibrium.
2. Polyphonic ring tone.
Polyphonic ring tone may be the reverse of the monophonic one. In this, harmony is heard in the music.
3. Master ring tone.
This really is simply the real music. Only it is compressed to be stored in the mobile phone memory. Grasp ring tones are where you can hear the music as you hear it from radio stations or any music medium.
How can you get your own music ring tone?
The Web have managed to get easier for people to download their favorite music ring tones. Today, there are lots of internet sites that are providing downloads, whether paid or free. For you to get the specific types that have the sort of music that you prefer all that is needed to be done is.
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A rusted wrench
"I found this on the Lindsey Street. It's a tool used for turning nuts and bolts."
Opens bolted box containing the old bronze key
Lindsey Street, West South Vale
Silent Hill 2
The Wrench is an item in Silent Hill 2. It is found on the porch of a house in Lindsey Street in dark South Vale. A map in the director's room of Brookhaven Hospital marks the location of this wrench and a letter. Unlike the later games, the wrench is not used as a weapon.
The wrench is used to open the buried box in Rosewater Park, beneath the statue of Jennifer Carroll. The box is bolted shut and contains an old bronze key, which is needed to enter the Silent Hill Historical Society.