text:
Best Of :: Arts & Entertainment
Born in Guatemala and raised in Miami, Oscar Isaac is the movie star the Magic City has been waiting for. Early in his career, Isaac had a few turns on television, and like seemingly every aspiring actor, he did an episode of Law and Order. But it was his stunning, soulful turn as the title character in the Coen Brothers' Inside Llewyn Davis that earned Isaac bona fide star status. Set in 1960s Greenwich Village, Inside Llewyn Davis tells the story of a struggling folk singer. Davis is deeply unlikable — selfish, self-centered, and rude — but in the hands of Isaac, he's a layered character whose flaws make him human. It's not surprising that Isaac was nominated for a Golden Globe for his nuanced portrayal. Isaac followed up his star-making turn with A Most Violent Year, proving he has a knack for complex roles. But if his first notable films were all about establishing his acting cred, the next are about turning the actor into a marquee name. Next up for Isaac are three big-budget action flicks. He's set to star as X-wing pilot Poe Dameron in Star Wars: The Force Awakens and the currently untitled Star Wars: Episode VIII. Isaac will also join another powerful franchise when he plays a villain in 2016's X-Men: Apocalypse. Whatever Isaac is up to next, we'll be watching. Frankly, we can't keep our eyes off him. Call us, Oscar!
Sidebar is packed with contradictions. One of its owners used to work at Opium Group, the bottle-service-king of South Beach that manages clubs like Mansion and SET. Another used to be the manager at Bar, a dearly departed downtown hipster hole in the wall. Their former employers, in other words, represented diametrically different dimensions of Dade nightlife. At Sidebar, the cavernous inside — with black walls, a stage, and a large dance floor — is the perfect place to be drowned in sound and to dance the night away. The ample outdoor area, in contrast, provides a place to catch a break and some conversation. On Wednesday, Sidebar features live jazz, Fridays is for hip-hop, and Saturdays are open format. It's ladies' night on Thursday, when there are the standard free drinks at the beginning of the night for women — but also free ice cream for all. Sidebar can't even be easily geographically categorized. It sits at the juncture of Brickell and Little Havana. And yet all these elements come together perfectly. Sidebar isn't trying too hard to be one thing, but it's not trying too hard to please everyone either. It's just great.
Readers' choice: Ball & Chain
Coyo Taco is a bright, fast-casual taco joint in Wynwood — with a dark secret. To find it, walk past the bathrooms and down the hall. There, you'll find a small, square room, softly lit by novena candles. A DJ plays a mix of soft house music, and people lounge on comfortable sofas. You've found Coyo Taco's hush-hush bar. The small space is home to 50 tequilas and mezcals, all of which can be mixed into the bar's inventive cocktails created by Coyo partner Anna Robbins. There's a banana margarita, called the Anna Bannana (the extra "N" refers to Robbins' childhood nickname), made with a rare Brazilian banana liqueur, and rimmed with sal de gusano, a Mexican salt made with ground gusano worms (the same ones getting drunk at the bottom of your Mezcal bottle). For health nuts falling off the wagon, there's a chia margarita. But with 100-degree heat fast approaching, go for the bar's PaletaRitas ($14). A locally made paleta is cut in half. One part is used in the margarita; the other half serves as both garnish and refreshingly icy swizzle stick. In flavors like cocopassion and chili cucumber, these PaletaRitas are the most refreshing and boozy treat in Miami. The fact that they're served in a secret bar filled with lit effigies of saints pushes the coolness factor off the charts.
You say you want your cheap drinks with a side of ribs? Come on down to Billy's Pub Too, friend. An average bar might have a two-hour window of discounts known as "Happy Hour," but Billy's has its time frame stretched to a full workday. That's correct; it runs an eight-hour Happy Hour from 4 p.m. until midnight with drink specials. It also ups the ante on Thursdays, when you can get 99-cent beer with a valid college ID. If you are looking for more than cheap booze, Billy's boasts four pool tables, a back patio with a tiki bar, and foosball to keep you busy. And don't forget those ribs. Mr. Cobb's kitchen menu has wings, burgers, and Southern sides, but it's the ribs that are completely memorable, sticking Billy's firmly in your mind, teeth, and fingers. You can get a full meal of a quarter rack of ribs and fries for just $8.75. South Beach can keep its $18 cocktails — you'll have a better time up north, where the meat falls off the bone and the drink specials never expire.
Readers' choice: Duffy's Sports Grill
Ball & Chain likes to tout its history — for good reason. The joint opened in 1935, after all, near the tail end of the Great Depression. For two decades, it reigned as one of Miami's most celebrated nightclubs, where greats like Billie Holiday and Chet Baker belted it out nightly. However, it closed in 1957 just as the Cuban immigrants who gave Little Havana its name began arriving in big numbers. It wasn't until last fall that partners Bill Fuller, Zack Bush, and Ben Bush decided to the revive the lounge. Except for the exposed ceiling and rafters, almost everything that was original to Ball & Chain was long gone. From that starting point, the owners painstakingly re-created the 1935 bar. The result isn't just a stunning reconnection to the city's past — it's a happening nightlife spot that's reintroducing the city at large to a neighborhood most people frequent only for the ethnic eats and cigars. Do yourself a favor and grab a spot at the bar to enjoy a mojito ($12) — one of the most authentic versions you'll find in Dade — or a Calle Ocho old-fashioned ($12) that uses tobacco bitters and actual tobacco leaves. Hungry? The Cuban spring roll ($8) takes the Cuban sandwich and wraps it inside a paper-thin dough. And though it's too late to see Holiday perform in person, Ball & Chain keeps the musical spirit alive with DJs, live bands, and singers all week.
Readers' choice: Ball & Chain
This strip-mall space in Hialeah used to be called Our Place — until that dive bar got busted by the feds May 2, 2014, for drug dealing and illegal gambling. Now under new ownership, the bar has gone legit. Architect Landy Lamas and builder Mo Lacayo have given these formerly sleazy digs a major face-lift, a fresh booze list, and a new name, opening as the Bend Liquor Lounge in February 2015. "This was our local watering hole, our favorite dive, until it started going downhill," Lamas told New Times just after the fixed-up boozing spot began slinging drinks. "The bar was opened in the '70s but had been muddled up by shabby remodels. After stripping it down to its bones, we could appreciate its original spirit and decided to build on it. The '70s was a key time for the development of the area, and we thought of nothing more fitting for a quote-unquote local bar." As for the brand of intoxicants being peddled at the Bend, there's $2.50 beer (Miller High Life, Rolling Rock, Coors Banquet, Pabst Blue Ribbon), $6 local pints (Biscayne Bay Brewing, Wynwood Brewing, M.I.A. Brewing), and $8 classic cocktails too. But no more cocaine, weed, or molly. Sorry, old-timers.
Readers' choice: Finka Table & Tap


text:
Mike Wall
If Only I Could / Inkognito
Label: wall music limited
12" Germany
- Techno
"Passion is the driving gear."
DJ, Producer and Label Owner Michael Schwarz stands for music with passion and love for the detail. Less is more and thats the reason why Michael Schwarz were attracted Techno and minimal sounds.
Since 2003, he once produced Hardtechno and Schranz - that he published at uptrax.de, now Techno and Deep Techno and improved with every release his sound technical amendments and refinements. 2007 started his DJ career and thus the jump in the deep-techno scene. With the help of his music, he supports numerous campaigns such as "DANCE4LIFE", "LAUT GEGEN NAZIS" or "PETA. In 2005 he founded his own campaign against fur-bearing animal breeding and fur fashion. With "Aktion Tierschutz", he supports in cooperation with other DJs and producers of the Electro-scene the "WWF". Michael Schwarz released his tracks at Hard Drive Records, 43 Recordings, Remuted, Brickwork, Hidden Records, Protect Records, Globaltraxx Records, HouzeSlave Records, credo, Remute, Super 6 Rec., Nachtstrom Schallplatten, Elektrax, Gynoid Audio, android muziq, Hybrid Confusion, Vilena Rec., Prosthetic Pressings, Black Plastic and many more.
6 Artikel. Du siehst: 1 bis 6.
Mike Wall
If Only I Could / Inkognito
VÖ-Datum: 30.12.2015
Label: wall music limited
Ryuji Takeuchi
VÖ-Datum: 10.03.2015
Label: Blind Spot Music
michael schwarz
she doesn't ask for
VÖ-Datum: 26.02.2014
Label: wall music limited
michael schwarz
VÖ-Datum: 07.08.2013
Label: hauptbahnhof musik
michael schwarz
VÖ-Datum: 25.07.2013
Label: praxxiz
m.a.d.a. + plankton
antiz ep part 2 (felix bernhardt rmx)
VÖ-Datum: 05.08.2011
Label: hidden recordings
6 Artikel. Du siehst: 1 bis 6.

subset: commoncrawl


text: 11/28/16 11/12/13 POPSUGAR Fashion Ultimate Guide Fall Denim Trends 2013 Calling All Blue-Jean Queens to Our Ultimate Denim Guide November 12, 2013 by Melissa Liebling-Goldberg 163 Shares Chat with us on Facebook Messenger. Learn what's trending across POPSUGAR. View on One Page Photo 45 of 73 Start Slideshow ADVERTISEMENT () Share This Link Copy What's Your Reaction? Thanks for your reaction Don't forget to share this with your friends! ← Use Arrows Keys → 45 Camo AE Camo Jegging Ankle ($50) Camo AE Jegging Ankle $49 from American Eagle Buy Now See more Camo Teen Girls' Denim Previous Next Ultimate GuideDenimShopping


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Russell Crow
Painted Gray, A Castle - Poem by Russell Crow
If the world needed saving with just one line
would I be the one to tell it
To spare someone's feelings, would I rearrange the question
it would've been a smart decision
for now I, I now own a castle
painted gray, a castle built for the scum of the earth
Just the perfect setting for me
I claim myself part of the innocence
well it's the image I want to portray
but I could never
it's in the chronicles of my never
I wrote last Halloween
I've done way much more than my fair share of damage
and this adds to the list...
I wish I could say I'm sorry
but all my heroism is resting inside my cowardice
I know I was brutally cold...I never meant to be so cold...
The truth was better kept secret
and fury is the gale of the storm swinging my way
I'm going to take it like a man
I won't say anything, nothing at all
I don't wish to be at fault again...
Nothing ever goes the way it should
it's a gigantic boomerang that keeps impaling me in my stony face
a notion I've tried to resist
too bad, I know it all too well
I've been living like this for 3 years now
Hear me now, here and now
I'm sorry, I realize I sound similar to a broken record in the attic
I always mean what I say, my thoughts whisk me away
I'm not cold-hearted, just cold blooded
still confused because reality keeps kicking me down
surrounded by silence, maybe that's what I need
but my mind is the quietest place I've visited
and I can always hear the echos of my thoughts
The echos of a song I heard in the morning
all is irrelevant now
my world keeps collapsing and repairing
the flower garden I planted
withered yesterday for the melancholy, sadness mixing in the air
Lying is not my strongest point nor do I want it to be
Being sweet and kind has always been my motto
but it's more of a weakness
since society treats it as one
This is a broken serenade
a broken serenade too far-fetched and from the answer
This is a shifting slideshow of a half version
of an apology and a symphony of pain it is to be losing
all I promised to keep together
There's no reason for me to be forgiven
I'm a deserted wolf in a human body
A body that has a beating heart
a beating heart that says I'm in love with you
Comments about Painted Gray, A Castle by Russell Crow
Karen Gonzalez-videla (6/17/2013 4:34:00 PM)
Oh my god! This is totally unbelievable. I just finished reading a poem of yours thinking that was incredible. This is shining in front of my eyes! It is better than silver, better than all the gold in this world. You write with such a fantastic passion, and I can tell by reading your beautiful poems that you will be a brilliant poet one day. If you are adult already, become one whenever you want; if you are a kid, keep writing, though you will outshine in this world of art. You have gained a fan today, and when you become a poet, just let me know, so I can go to a bookstore and buy all of your books :) (Report) Reply
Gajanan Mishra (5/20/2013 6:01:00 AM)
I am in love with you, this is the truth, thanks.
I invite you to read my poems and comment. (Report) Reply
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Maya Angelou
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Stopping By Woods On A Snowy Evening
Robert Frost
A Dream Within A Dream
Edgar Allan Poe


text: Posted December 12, 2013 That is ridiculous to say that coaching can solve any problem. He gives the players the plan but they have to carry it out. I guess the game plan was for Newton to hold the ball for 4 seconds and then back out into oncoming pressure so he got sacked or overthrowing receivers by 10 yards. I didnt say coaching can solve any problem. However scheme and play calling wise is all on the coaches. Execution is on the players. So if I were to see Cam getting the ball out in 2-3 seconds or scrambling and throwing the ball before WR breaks but the plays simply fail due to drops / incomplete passes / cam getting minimal yards on the scramble / ints THEN I would put in on the players. I am not seeing the above. I am seeing the same play calling ie ball control / run / longer routes etc. 1 person likes this Share this post Link to post Share on other sites


text:
1964 Chevrolet Corvette
Price: US $20,200.00 Item location: Sacramento, California, United States
- Condition: Used
- Make: Chevrolet
- Model: Corvette
- Type: Coupe
- Trim: 2 door coupe
- Year: 19640000
- Mileage: 1500
- VIN: v6538439821
- Color: black
- Engine size: 383 stroker
- Number of cylinders: 8
- Transmission: Manual
- Interior color: tan
- Vehicle Title: Clear Want to buy? Contact seller!
19640000 Chevrolet Corvette1964 Chevy Corvette Car has 30k put into it within the past 2 1/2 years.engine is a brand new 383 stroker with less than 1000 miles on itnew carb, adiator, ower steering, ower brakes, ew tires, rand new interior, ustom seats from an 80 corvette, ull custom auto meter gauges, ith a custom cluster. 10,000 dollars spent on parts underneath the car(suspension etc.)bluetooth stereo system and a woodgrain steering wheelcar has been sitting in a garage for the past 16 months. I have nowhere to keep it so regretfully it needs a new homecar runs and drives amazing.
On Jul-31-15 at 14:21:06 PDT, eller added the following information:
correct vin is 40837S117201


text:
I clearly understand that I can never be a true Southerner until my cold dead body is laid to rest in Southern soil.
Dear nofaith: The question remains: "What is their end game?"
nofaith: You believe they don't have the Supreme Court after Bush v. Gore? and what about that 60 vote majority thingy in the Senate - wtf is that about?
I can't help wonder what the GOP's end game is. In SC they are in control of all the branches of government, yet what do they have to show for it? Federally the have two of the three branches, yet what do they have to show for it?
What is their end game? Bringing back the 7 day work week? Ending child labor laws? No taxes for those making over $30,000 a year? NRA membership for new borns? Bringing back Pauper's Prisons? Shoving lesbian and gay citizens back into the closet? Not allowing women to have credit cards or the right to vote? African Americans being counted as 3/5's human? Then end of science as a study in schools? The end of public schooling? When they obtain total and complete control of our government what will they do? What is their end game? What will feed their beast?
DV - "Don hasn't spoken at a meeting in years. (Many felt at times the need to check for a pulse.)" <--- Callous. Don is the hands behind just about every outfit worn by every dancer seen in the CBT productions.
DV - I am not "attacking, pointing fingers" at the board only. This is a FUBAR created by the Artistic Staff and many, many boards over the years.
Let me state very clearly I believe that if a person is to serve on a not-for-profit arts board they should come to the table with a check. A large check, because if they don't there is no way they can ask others to donate to the organization. I believe that boards of arts organizations should be responsible for raising 25% - 30% of the operating budget. Grants, box office receipts, and classes do not begin to cover the cost of running an operation that relies on bodies to deliver the product. Bodies that need to be covered in costumes, lit with lights, have music to dance to, seats for the audience to sit in and a performance space. I believe that board of directors are responsible for the financial stability of the organization they choose to oversee. I believe that Artistic directors and Choreographers should not have sway over the check books - that's what business managers and treasurers are for.
I know exactly what went down over the past two seasons. I saw no change in the overall attitude in the Artistic staff. I was not inclined to serve on a board that can not function under those circumstances. I think before I jump into a den of vipers. You do not know me so, unless you would like to meet for a civil lunch don't start flinging aspersions my way.


text:
Experience this holiday favorite in all its historical glory as Nicholas McGegan and America's leading period instrument Orchestra and Chorale perform with an international cast of stars. These very special holiday performances are available to all subscribers as an additional Add-On concert.
HANDEL Messiah, HWV 56
Nicholas McGegan, conductor
Yulia Van Doren, soprano
Diana Moore, mezzo-soprano
James Reese, tenor
Philip Cutlip, baritone
Philharmonia Chorale, Bruce Lamott, director
Friday December 8, 2017 @ 7 pm | Herbst Theatre, San Francisco
Saturday December 9, 2017 @ 7 pm | First Congregational Church, Berkeley


text:
#Oscar Pizza Guy Was Real!
Even though finding out that this ELLEN bit was not staged, I was not as excited about it as everyone else.
I mean, it was cute how they were playing off the fact that all the celebs STARVE during the show.
That guy is probably pissed he didn't DVR the show before he left for work.
[PHOTOS] 2014 Oscar Highlights
(click on the arrow to the right of the picture to scroll through)


text:
Trends of population-based breast cancer survival in Germany and the US: Decreasing discrepancies, but persistent survival gap of elderly patients in Germany
Epidemiology, prevention and public health
Studies have revealed both higher cancer survival in the US than in Germany and substantial improvement of cancer survival in the past in these countries. This population-based study aims at comparing most recent 5-year relative survival of breast cancer patients and preceding trends in both countries.
Women with a first invasive breast cancer diagnosed and followed up between 1988 and 2008 from Germany and the US (utilizing data from the Saarland Cancer Registry and the Surveillance, Epidemiology, and End Results Program, respectively) were included. Period analysis was used to derive most up-to-date 5-year relative survival and preceding survival trends according to age and stage.
Since 1993, age standardized relative survival has steadily improved in Germany and the US to 83% and 88%, respectively. In the period 2005–08, relative survival of localized cancer was above 97% in both countries, and 79% and 83% for locally/regionally spread breast cancer, respectively. Prognosis of metastasized disease has remained very poor overall, with improvement essentially being restricted to younger patients. The proportion of patients diagnosed with localized breast cancer was consistently higher in the US. If adjusted for stage, the differences in relative survival between both countries diminished over time and eventually disappeared.
Similar survival is now observed in both countries for patients below the age of 70 years, but in Germany survival is still much lower for elderly patients. The observed trends point to treatment advances as a major cause for improved survival. However, substantial differences in mammography usage existed between both countries and might probably also account for the observed differences (to a lesser extent, also differences in health care systems, and delivery of cancer care). Encouraging, survival of breast cancer patients has improved in Germany to a much greater extent than in the US, albeit the persisting survival gap for elderly patients in Germany requires particular attention by researchers, public health authorities, and clinicians.
Population-based studies have shown a decrease in breast cancer (BRC) mortality during the past two decades in Germany and the US
Prolongation of cancer survival may have two principal causes: firstly anticipation of tumour diagnosis or even overdiagnosis by early detection and secondly increased survival due to improved effectiveness of cancer treatment. The time gained if a cancer is diagnosed earlier in a pre symptomatic stage due to screening is called lead time and artificially increases survival time. By itself, early detection does not affect the course of the disease. Therefore, screening requires treatment administered earlier to be effective and to postpone the death of the patient.
Overdiagnosis results from detection of malignant lesions that would never have progressed and presented clinically during the patient's lifetime and survival analyses yield too optimistic estimates due to the inclusion of these non fatal cancers.
Therefore, comparative studies of population-based cancer survival should particularly take into account differences in stage distribution and early detection activities, to understand underlying mechanisms of observed trends over time or differences between populations.
Up to now, available comparative population-based studies on BRC survival were often limited as they provided survival trends stratified by age only (e.g.
A recently published study reported trends of BRC survival by age and stage in Germany
For Germany, data from the population-based Saarland Cancer Registry were used. The registry covers the federal state of Saarland, Germany, with approximately 1.04 million residents in 2006 and operates since the beginning of the 1970s. Cancer notification is mandatory by law. The registry obtains notifications from pathology laboratories, hospitals, radiotherapy departments, outpatient clinics, and general practitioners. The completeness of case ascertainment is estimated above 95%
The database from Saarland included 16,014 women aged 15 years or older diagnosed with invasive BRC (ICD-10 code: C50) between 1988 and 2008 (irrespective of previous primary cancers of other sites). Patients with a previous primary malignant tumour of the breast were excluded.
Mortality follow-up based on death certificates was available until end of 2008. Linkage with population registries was additionally performed for all patients assumed alive end of 2008 to identify patients lost to follow-up. Patients having migrated out of the Saarland region contributed survival time until removal. Patients for whom linkage with population registries was not possible (e.g. due to erroneous patient identifiers) were classified as "no follow-up available" and excluded from the analyses.
For the US, data from the Surveillance, Epidemiology, and End Results Program (SEER) were used and included the SEER-9 registries (states of Connecticut, Iowa, New Mexico, Utah, Hawaii, metropolitan regions of San Francisco-Oakland, Detroit, Atlanta, and Seattle Puget Sound area) from 1988 with extension to the SEER-13 registries (Alaska, regions of San Jose-Monterey, Los Angeles and Rural Georgia) from 1992 until 2008, covering a population of approximately 41.2 million residents in 2004–08
The following data items were used: month and year of diagnosis, age at diagnosis, T classification, stage (categories: 'localized': T1-3N0M0 tumours; 'local/regional spread': T4M0 and N + M0 tumours; 'distant metastasis': any M1 tumours; unknown extent), basis of diagnosis, month and year of end of follow-up and vital status. Stage was classified according to summary stage reported by the registries or TNM information
Additionally, incidence data of invasive and in situ BRC (ICD-10 codes: C50 and D05), mortality data (ICD-10 codes: C50), and population data were used from the registries.
The data used for this study are routinely collected by cancer registries according to state legislation for the purpose of monitoring cancer incidence, mortality, and outcomes and the anonymized data were used according to the respective provisions for the use of research data.
Statistical analyses
Age-standardized rates (ASR) and truncated age-standardized rates (TASR) per 100,000 person years using the 2000 US standard population
A description of the BRC patients with regard to age, T classification, stage, basis of diagnosis, and DCO notification was provided for intervals of four calendar years between 1989 and 2008.
Relative survival (RS) which quantifies excess mortality due to the cancer (capturing both direct and indirect mortality) was derived as ratio of observed survival and expected survival for these persons derived from life tables of the underlying populations with respect to sex, age and calendar time (race was also considered for US patients)
Life tables for Saarland were calculated for intervals of 5 years since 1990 from mortality and population data for single ages provided by the state statistical office (further details may be found elsewhere
Period analysis was used to obtain most up-to-date estimates of RS. In addition to right censoring, observations are left truncated at the beginning of a calendar period
Period estimates of 5-year RS were derived for subsequent calendar periods of four years between 1993 and 2008. To avoid potential artefacts when combining classical cohort based estimates derived for calendar periods with complete follow-up and period estimates for the most recent calendar period, the period approach was continuously used for the entire study period.
To test for linear trend in RS over time, model based period analysis was employed. Poisson regression models for relative survival were fitted modelling the logarithm of the excess number of deaths with a linear predictor of follow-up year (categorical), age group (categorical) and calendar period (numerical), incorporating the logarithm of person time as offset
Besides crude survival, age standardized survival was derived as weighted average of age group-specific survival based on weights from the International Cancer Survival Standards (ICSS)
Age standardized incidence of in situ BRC was about four-fold in the US compared to Germany (ASR: 30.3 vs. 8.5, respectively, in 2005–08). In the US, incidence among women aged 50+ years was similar and 5-fold compared to younger patients (TASR increased to 79.7 and 76.6 vs. 16.7, respectively, in 2005–08). In Germany, the incidence approximately tripled among patients aged 50–69 years (TASR: 22.6) and doubled among the other age groups (TASR: 5.8 and 14.9, respectively).
During the study period, a decrease of BRC mortality was observed in the US across all age categories (ASR: minus 28% to 23.1 in 2005–08), whereas in Germany mortality slightly decreased only among patients below 70 years of age but increased among older ones (ASR remained virtually unchanged: -3% to 30.4).
Trends of 5-year RS between 1993 and 2008 stratified by age group and stage are given in Table
In Germany, survival of patients aged 70+ years did not improve to the same extent as survival of younger patients (+5.6% units to 74.9% vs. +13.5% units to 88.4% in 2005–08; p-values: 0.026 and <0.001, respectively). In the US, survival of elderly patients improved to a lesser extent (+2.1% units to 85.7% vs. +5.3% to 89.7%; p-values: 0.001 and <0.001, respectively). As a result, a difference of about 11% units persisted in 5-year RS of elderly patients between Germany and the US.
Age standardized 5-year RS of localized BRC was 98.7% in Germany and 97.3% in the US in 2005–08. Five-year RS of BRC with local or regional spread was 78.6% and 82.8%, respectively. If distant sites were already involved at diagnosis time, 5-year RS was 23.7% and 26.7% in both countries, respectively.
Since 1993, most improvement of age standardized 5-year RS was observed in Germany for locally/regionally spread BRC, followed by localized disease (+14.6% units and +7.3% units, respectively; p-values: <0.001). At the same time, improvement of survival of US patients who already had much better prognosis in 1993–96, was less pronounced (+7.6% units and +1.6% units, respectively; p-values: <0.001) and the gap in 5-year RS between both countries reduced to 4.2% units and 1.4% units in 2005–08, respectively. Survival of distant BRC improved by 3.3% units (p-value: 0.106) in Germany and by 6.5% units in the US (p-value: <0.001).
Part of the overall survival differences between Germany and the US resulted from a higher proportion of patients with less advanced BRC in the US. Adjustment for stage mix reduced survival differences between both countries. In 2005–08, these differences eventually had disappeared (87.9% and 88.1%, respectively).
Differences in most recent stage-specific 5-year RS and preceding trends between patients aged > = 70 years and younger ones were varying. Survival of patients with localized BRC was equally high among elderly and younger patients (in 2005–08, it was 96.6% vs. 97.8% and 97.4% vs. 97.2%, respectively, in Germany and the US). Survival of patients with locally/regionally spread BRC improved less and was much lower for elderly patients in both countries (in 2005–08, it was 70.8% vs. 85.1% and 77.5% vs. 87.0%, respectively). Among patients with metastasized BRC, improvements were highest for patients <50 years of age (+18.2% units and +11.9% units to 29.6% and 38.8%, respectively; p-values: 0.029 and <0.001), but no substantial improvement was seen for elderly patients (changes of −1.8% units and +2.1% units to 15.3% and 19.4%, respectively; p-values: 0.712 and 0.045).
Age standardized 5-year RS of BRC patients with unknown or missing stage information was varying in both countries. In Germany, it was about 80% during the study period. In the US, it varied slightly between 55% and 58% between 1993 and 2004, but dropped to 45% in the most recent calendar period.
In this study, most recent 5-year RS of female BRC patients from Germany and the US and preceding trends were analyzed using data from the population-based Saarland Cancer Registry and the SEER 9/13 registries. In 2005–08, age standardized 5-year RS was 82.5% and 88.1% for all stages combined, 98.7% and 97.3% for localized BRC, 78.6% and 82.8% for BRC with local or regional spread and 23.7% and 26.7% for tumours with involvement of distant sites at diagnosis, respectively, in Germany and the US.
During the study period, most overall improvement of 5-year RS was observed for locally/regionally spread BRC, followed by localized tumours. As increases were more pronounced among German patients, the existing discrepancies between the two countries have decreased over time. Among patients with metastasized BRC, substantial improvement was seen only for patients below 50 years of age. The differences in stage-adjusted survival have entirely disappeared over time.
In Germany, 5-year RS and its improvement over time were inferior for patients aged 70+ years resulting both in an increased age gradient in Germany and prevailing differences in 5-year RS of elderly patients between the two countries.
The health care systems differ fundamentally in both countries. In Germany, health care is decentralized with private practice physicians and mostly public hospitals providing most ambulatory and impatient care. In 2007, 95.7% of the population had health insurance coverage through public or private health insurance
In the US, organized breast cancer screening was introduced (with regional differences and different types of programs) at the beginning of the 1990s
In Germany, implementation of organized mammography screening started only recently in 2003. The quality-assured programme offers women aged 50 to 69 years a screening mammography every two years. Prior to its introduction in 2006, only opportunistic screening was available in Saarland
In the US, organized mammography screening started earlier and was intensely used even among younger and elderly women. Data on the usage of opportunistic mammography from Germany prior to the introduction of the organized screening are sparse. Based on the data available, it may be assumed that mammography usage and screening was much lower in Germany during the study among all age categories.
Higher usage of mammography in the US compared to Germany is well reflected in the presented incidence data. Higher proportions of earlier stages and a fourfold incidence of in situ tumours in the US correlate with the differences in the adoption and intensity of mammography screening
Diagnosis of in situ lesions of the breast is usually based on a microscopic examination and basis for a notification from a pathology laboratory. According to the registration practises of the SEER registries and the Saarland Cancer registry, we assumed the observed differences in incidence of in situ tumours to represent differences in screening activities (or prevalence of risk factors) rather than differences in case ascertainment.
The observed drop in incidence of invasive BRC in the US after the year 2000 may reflect the change in the prescription of hormone replacement therapy
To account for overestimation of survival of patients with screen detected cancers we performed analyses stratified by age and stage. This at least partly allowed combining patients with comparable stages with regard to begin of follow up, even if lead time effects remain present within all stages. Furthermore, beneficial effects of screening have even been demonstrated between clinically and screening detected tumours of same stage
The introduction of organized screening in Germany at the end of the study period, the higher intensity of mammography usage in the US on the one hand, and a much higher increase in 5-year RS in Germany on the other hand, support the presumption of advances in the treatment of the disease and adoption of treatment recommendations as a major cause of the remarkable gain in survival in Germany and advanced disease during the study period. However, increased early detection surely has interfered with these developments. As an observational study, it cannot fully resolve the contributions of improved treatment and screening as underlying reasons of the striking increase of 5-year RS in Germany.
Major advances in BRC treatment during the past 20 years included improved staging (e.g. more sensitive medical imaging and sentinel node dissection), propagation of breast conserving surgery and adjuvant radiotherapy for effective local treatment of early stage disease and new agents for chemotherapy and antiestrogen treatment, and targeted biologic agents. Treatment according to consensus recommendations and tailored to the patient's individual risk and a wider range of treatment options has increased the number of patients eligible for cancer-specific treatments.
For elderly patients, co-morbidity and differences in the delivery of cancer care are well documented (e.g. delay in seeking cancer care and influences of co-morbidity on selection of cancer treatments
The widespread use of mammography among elderly women in the US (the proportion of women aged 75+ years reporting to have had a mammogram within the last two years increased from 17.3% to 54.7% between 1987 and 2005)
In the interpretation of the findings, a number of limitations and strengths should be considered. A major limitation is the restricted availability of clinical information. Although rather crude, the used staging scheme allowed survival estimation for three rather distinct groups of BRC patients with regard to available treatment options. Tumour stage and T classification were sufficiently complete.
The proportions of patients with missing stage were much higher in Germany than in the US. Survival of German patients with unknown stage was comparable to overall survival. Survival of US patients with unknown stage was much lower, possibly due to higher proportions of patients with clinical cancers of more advanced stage.
Further determinants beyond age and tumour stage, e.g. information about administered treatments, socio-economic status, or co-morbidity were not available. Neither was the method of first detection to consider screening effects as well as lead time, length time and overdiagnosis
The included registries operate as established registries with high levels of completeness of case ascertainment and follow-up
The 17 registries currently included in the SEER programme cover approximately one fourth of the US population. The covered regions are regarded reasonably representative for the US, although the population is categorized as somewhat more urban, with less unemployment, higher education and higher smoking prevalence
To avoid artefacts in the most recent survival trends due to the inclusion of the four registries which joined the SEER programme in 2000 (California regions, Kentucky, Louisiana and New Jersey), we restricted the analyses to the SEER 13 regions. Additionally performed analyses of these four regions provided almost identical survival estimates for 2005–08 (differences of overall, age- and stage-specific estimates ranging between 0.2 and 1.7% units; data not shown).
The validity of cancer diagnoses may be considered high, as almost all tumours were microscopically confirmed. When interpreting stage-specific survival, stage migration (a shift of classification towards more advanced stages due to increased sensitivity and improved accuracy of diagnostic procedures) has to be kept in mind
In addition to comparability issues of included patients and tumour stages, the completeness of follow-up and estimation of background mortality is crucial in survival comparisons.
The proportions of DCO notified cases were rather small in the used databases. Under such circumstances, the effects of the exclusion of DCO cases from the analysis or a possible correction for DCO cases are expected to be very small according to recent work
RS as a measure for survival in the hypothetical situation where the disease under study would be the only cause of death (denoted as net survival) is dependent on the general population mortality (the composition of cancer patients under follow-up changes over time with regard to demographic characteristics)
The strategy of using the period analysis approach for all subsequent calendar periods aimed at deriving most up-to-date estimates (even in case of ongoing improvement) and consistent use of methodology to prevent potential artefacts in the derived time trends due to a mixture of classical cohort based and period survival estimates.
The observed trends of RS and corresponding p-values were considered on their own and carefully interpreted in the light of further empirical observations. Therefore, we did not account for multiple testing despite the overall number of performed statistical tests for significance
Follow-up was almost complete for both the German and the US patients. It has been shown, that national life tables may not adequately describe overall mortality of a subpopulation and result in biased estimates of RS (e.g. for the US, use of national life tables overestimates SEER survival estimates)
As the aim of population-based survival analyses is to provide a picture of the overall control of cancer in the societies compared, we did not restrict the analyses to any ethnic subpopulation (e.g. inclusion of white US patients only). Otherwise this would result in an inappropriate selective exclusion of socio-economically less privileged patients in one of the countries compared. Additional analyses were performed with a restriction to white US patients only. The effects of such an exclusion were generally small (estimates of crude, age standardized and stage adjusted survival estimates of whites were 1.5% units above estimates of all races combined), but considerable effects were observed for younger patients and more advanced stages (e.g. survival of whites aged 15–49 years with metastasized BRC was 4.5% units higher than estimates of all races combined; data not shown).
The findings may have several important implications. Transatlantic differences in 5-year RS and tumour related excess mortality of BRC patients revealed in previous studies have continuously decreased in recent years.
The observed survival trends point to advances in BRC treatment as a major cause for the gain in prognosis in both countries. Differences in early detection activities and effects due to lead time and overdiagnosis further account for the observed differences.
Whereas most overall improvement was observed for patients with locally or regionally advanced disease, prognosis of patients with distant sites involved at diagnosis is still limited. Despite interim advances in the availability of (increasingly costly) treatment options for patients with metastasized disease, only some moderate overall improvement has been observed for these patients during the past 15 years. The implementation of mammography screening in Germany in recent years will hopefully further reduce the numbers of breast tumours with advanced stage.
Particularly for Germany, this study indicated striking deficits in cancer survival of elderly patients. The gap in cancer related mortality between elderly patients and younger ones in Germany has even increased over time. Inequalities in the access to and provision of cancer care of elderly patients need to be jointly focussed on in future by cancer research, health care policy, and the medical community.
BRC: Breast cancer; SEER: Surveillance, Epidemiology, and End Results Program; ASR: Age-standardized rate; TASR: Truncated age-standardized rate; DCO: Death certificate only; RS: Relative survival; ICSS: International Cancer Survival Standards.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
This study was designed by BH and HB. BH prepared and managed the dataset and analyzed the data. BH and HB provided interpretation of the results. BH drafted the manuscript and HB critically reviewed and revised the draft. Both authors have approved the final version of the manuscript.
This work was supported in part by the German Cancer Aid (Deutsche Krebshilfe; grants 70-3166-Br5, 108257 and 108761). The German Cancer Aid had no role in the design, the data collection, the analysis, the interpretation of the results, the writing of the manuscript, or in the decision to submit the manuscript.
Breast cancer incidence and mortality trends in 16 European countries
Disparities in breast cancer mortality trends between 30 European countries: retrospective trend analysis of WHO mortality database
Global patterns of cancer incidence and mortality rates and trends
Effect of screening and adjuvant therapy on mortality from breast cancer
Screening for breast cancer
Survival trends in European cancer patients diagnosed from 1988 to 1999
Trends in cancer survival in 11 European populations from 1990 to 2009: a model-based analysis
Up-to-date estimates of breast cancer survival for the years 2000–2004 in 11 European countries: the role of screening and a comparison with data from the United States
Cancer survival in Germany and the United States at the beginning of the 21st century: an up-to-date comparison by period analysis
Breast carcinoma survival in Europe and the United States
Cancer survival in five continents: a worldwide population-based study (CONCORD)
Trends in breast cancer survival in Germany from 1976 to 2008-A period analysis by age and stage
Estimating completeness of cancer registration: an empirical evaluation of the two source capture-recapture approach in Germany
Age adjustment using the 2000 projected U.S. population. Healthy People 2010
The relative survival rate: a statistical methodology
Comparison of Four Methods for Estimating Complete Life Tables from Abridged Life Tables Using Mortality Data Supplied to EUROCARE-3
Period analysis for 'up-to-date' cancer survival data: theory, empirical evaluation, computational realisation and applications
Up-to-date long-term survival of cancer patients: an evaluation of period analysis on Swedish Cancer Registry data
Up-to-date long-term survival curves of patients with cancer by period analysis
Use of period analysis for providing more up-to-date estimates of long-term survival rates: empirical evaluation among 370,000 cancer patients in Finland
Up-to-date and precise estimates of cancer patient survival: model-based period analysis
Standard cancer patient population for age standardising survival ratios
periodR - an R package to calculate long-term cancer survival estimates using period analysis
Health spending in the United States and the rest of the industrialized world
Breast cancer screening programmes in 22 countries: current policies, administration and guidelines. International Breast Cancer Screening Network (IBSN) and the European Network of Pilot Projects for Breast Cancer Screening
Progress in cancer screening practices in the United States: results from the 2000 National Health Interview Survey
Epidemiological aspects of cancer screening in Germany
Epidemiological investigations of the chances of preventing, recognizing early and optimally treating chronic diseases in an elderly population (ESTHER study)
Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach
Mammography and Cervical Cancer Screening - A Systematic Review about Women's Knowledge, Attitudes and Participation in Germany
In situ breast cancer: incidence trend and organised screening programmes in Italy
Incidence of and treatment for ductal carcinoma in situ of the breast
Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes
Breast cancer incidence, 1980–2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status
The decrease in breast-cancer incidence in 2003 in the United States
Screen-detected vs symptomatic breast cancer: is improved survival due to stage migration alone?
Comorbidity in older surgical cancer patients: influence on patient care and outcome
Undertreatment strongly decreases prognosis of breast cancer in elderly women
Non-standard management of breast cancer increases with age in the UK: a population based cohort of women > or =65 years
Critical review of the management of early-stage breast cancer in elderly women
Standard treatment of female patients with breast cancer decreases substantially for women aged 70 years and older: a German clinical cohort study
EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary
Relative survival in elderly European cancer patients: evidence for health care inequalities. The EUROCARE Working Group
Trends in population-based cancer survival in Germany: to what extent does progress reach older patients?
Overdiagnosis and breast cancer screening
The surveillance, epidemiology, and end-results program database as a resource for conducting descriptive epidemiologic and clinical studies
How representative are the surveillance, epidemiology, and end results (SEER) program cancer data of the United States?
Building the infrastructure for nationwide cancer surveillance and control–a comparison between the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology, and End Results (SEER) Program (United States)
Representativeness of the surveillance, epidemiology, and end results program data: recent trends in cancer mortality rates
Generalizability of the surveillance, epidemiology, and end results registry population: factors relevant to epidemiologic and health care research
The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer
Deriving valid population-based cancer survival estimates in the presence of nonnegligible proportions of cancers notified by death certificates only
On estimation in relative survival
No adjustments are needed for multiple comparisons
Life tables for world-wide comparison of relative survival for cancer (CONCORD study)
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Fri., Nov. 6, 2009, 8:09 p.m.
Who is Major Nidal Malik Hasan?
Good evening, Netizens...
Who is this man? Obviously he is Army Major Nidal Malik Hasan, the gunman who went on a shooting rampage in Fort Hood, Texas, killing 13 people and wounding countless others. However that nor any of the other facts surrounding Hasan's life can explain why he acted as he did.
Yet this afternoon, reading in various places on the Internet I have heard him called a recent recruit to Muslim faith, a "sleeper" terrorist, perhaps part of a covert terrorist group intent upon more crimes, and the list of possibilities goes on and on. At least based upon what few facts we have about Hasan, perhaps none of the allegations are true. The FBI, Army military authorities and local and state police are still attempting to put together a cogent picture of what motivated Hasan, a psychiatrist, to "come unglued" and start killing people.
At present, on Friday evening, he is in a coma at the Brooke Army Medical Center at Fort Sam Houston in San Antonio in critical condition.
What little we know is Hasan is an American born in Virginia of Palestinian parents. Hasan graduated from medical school at the Uniformed Services University in 2003, said Sharon K. Willis, speaking for the school.
He then entered a psychiatry residency program at Walter Reed Army Medical Center, which he completed in 2007. He returned to the university for the disaster and military psychiatry fellowship in 2007. The first phase of that fellowship is earning a master of public health degree, which he completed in 2008. He completed the fellowship program in June. A month later, Hasan reported for duty at Fort Hood.
There is a considerable amount of evidence, mostly from his neighbors in the apartment complex in which he lived, that he was a gentle, caring and kindly person who most viewed as a decent man.
If Hasan lives we may actually get some answers about what motivated the man. If he dies of his wounds we may never know what motivated him to kill some of the people he was sworn to help.
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(Photo: Point Loma Nazarene University professor Dr. Jamie Gates presents at an anti-trafficking workshop hosted by Nazarene Compassionate Ministries in Johannesburg on May 19.)
A wide range of people participated in an anti-trafficking workshop co-hosted by Nazarene Compassionate Ministries and The Goal in Johannesburg on May 19.
The group of about 100 participants included Nazarene pastors and students, advocacy groups, visitors from California's Point Loma Nazarene University, and government officials from South Africa's social development department, justice department and police service.
This type of cross-industry collaboration is important in the fight against human trafficking, said Diane Wilkinson with the National Freedom Network, which unites the efforts of anti-trafficking groups in South Africa.
South Africa, where an estimated 100,000 victims are trafficked each year, is considered a highway for human trafficking. Recruiters use the country's reputation as an economic hub – a place with jobs, gold and money – to attract victims from other African countries with false promises of career opportunities, Wilkinson said during her presentation at the workshop.
Also presenting was Point Loma professor Dr. Jamie Gates, who spent much of his childhood in South Africa as a Nazarene missionary kid. Gate's is the Nazarene Church's lead human trafficking consultant in North America and is director of Point Loma's Center for Justice & Reconciliation. He has led Point Loma students on study abroad trips to South Africa every other year since 2005.
At the workshop, Gates gave examples of how Nazarene churches and universities can be involved in anti-trafficking efforts. The movement to train faith congregations about human trafficking is on the rise, he said.
"There's this growing awareness (about human trafficking), and now people are saying, 'What do we do?'" Gates said. "And yet, there's not a lot of good, solid research."
Point Loma is involved in anti-trafficking research and activism in San Diego, and it was the first university in the United States to provide a scholarship specifically for human trafficking survivors, Gates said.
South Africa is also seeing a rise in anti-trafficking collaboration among schools, police agencies, churches and nonprofits. For example, NCM's anti-human trafficking and gender-based violence coordinator Stephen Phillips has trained volunteers with The Goal, a South African organization that supports character development in youth, on how to talk to students about human trafficking. Nazarene Pastor Hubert Tiger is The Goal's co-founder and director.
On May 20 (pictured), volunteers with The Goal and Point Loma students taught eight classes at Eldorado Park secondary and primary schools about how to define human trafficking and avoid falling into a trap.
The volunteers acted out skits to show students how easy it can be to fall into human trafficking. In one skit, a girl enthusiastically accepts a job offer to work as a model in England. The "agency" says if she gives them her passport, they will take care of all the travel arrangements. In England, the girl finds herself enslaved in domestic labor, with her passport still in the hands of her recruiters.
Students at the school learned that human trafficking recruiters can be anyone, even a peer. They learned they can call human trafficking helplines, 08000 RESCU(73728) or 0800 555 999, if they sense danger. The students were encouraged to become advocates by sharing the lessons they had learned with friends and family.
(Photos by Daniel Mutowa)
To learn how you or your church can be involved in anti-trafficking efforts, contact Nazarene Compassionate Ministries' regional office in Johannesburg at firstname.lastname@example.com.
Click here to learn about NCM's Global Anti-Trafficking Fund and the work that it supports. Help spread the word about the anti-human trafficking efforts with your friends, family and community.
Copyright 2017 Africa Region - Church of the Nazarene. All Rights Reserved.


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Price on Application
An abbreviation for "Price on Application" which indicates that price is not quoted publicly and will be revealed only to qualified occupiers.
This property is unavailable
India Mill Business Centre
The original building, India Mill, was constructed in the Victorian era and was understood to have had been substantially refurbished in the late 1990's. Accommodation is arranged over six floors, a mixture of offices, workshop and storage. Mosley Mill was added significantly later and is of part brick and steel construction. Holme Mill forms a stand-alone industrial unit built in the 1970's which is of steel portal framed construction. The property is situated in Darwen, a small market town four miles south of Blackburn, eight miles north of Bolton and twenty two miles north of Manchester.


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The Washington Post has created a very well researched video on racism faced by Sikhs in the United States. The extremely knowledgable video will clear doubts of an ignorant person and provide understanding of the Sikh faith.
The case of Waris Ahluwalia has positively benefited Sikhs worldwide due to the massive media attention the incident received. An unfortunate incident is something which Sikhs know all to much about. Post 9/11, Sikhs have become victims of mistaken identity and targets at airports.
Waris in his numerous interviews has stated that he gets racially profiled at airports due to his appearance. He took the opportunity to educate the masses that Sikhs are fun and loving people.
Also, the response of Waris of spreading love has been applauded by people worldwide.


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|Specific References
|Related Products
|Human Cells
|Human Cell lysate that Human NEGR1 transfected / overexpressed for Western blot (WB) positive control. The whole cell lysate is provided in 1X Sample Buffer (1X modified RIPA buffer+1X SDS loading buffer).
|A DNA sequence encoding the human NEGR1 (NP_776169.2) (Met 1-Gly 324) without the propeptide was expressed, with a polyhistidine tag at the C-terminus.
|Val 38
|The secreted mature form of recombinant human NEGR1 consists of 298 amino acids and predictes a molecular mass of 32.9 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NEGR1 is approximately 45-48 kDa due to glycosylation.
|Cell lysate was prepared by homogenization in ice-cold modified RIPA Lysis Buffer with cocktail of protease inhibitors (Sigma). Cell debris was removed by centrifugation. Protein concentration was determined by Bradford assay (Bio-Rad protein assay, Microplate Standard assay). The cell lysate was boiled for 5 min in 1 x SDS loading buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% b-mercaptoethanol, and lyophilized.
|Modified RIPA Lysis Buffer: 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1mM PMSF.
|12.5% SDS-PAGE Stained with Coomassie Blue after protein purification.
|Samples are stable for up to twelve months from date of receipt.
|1. Centrifuge the tube for a few seconds and ensure the pellet at the bottom of the tube. 2. Re-dissolve the pellet using 200μL pure water and boil for 2-5 min. 3. Store the lyophilized cell lysate at 4℃. After re-dissolution, recommend to aliquot it into smaller quantities and store at -80℃.
|1 X Sample Buffer (1 X modified RIPA buffer+1 X SDS loading buffer).
|Store at 4℃. After re-dissolution, aliquot and store at -80℃.
|Western blot (WB): Use at an assay dependent dilution.
Other Applications: Not tested.
Optimal dilutions/concentrations should be determined by the end user.
Neuronal Growth Regulator 1, NEGR1, also known as neurotractin, or KILON, which belongs to the immunoglobulin superfamily, IgLON family. This GPI-linked cell surface glycoprotein NEGR1 is composed of three Ig-like domains and belongs to the IgLON subgroup of neural IgSF members. It is expressed in two isoforms with apparent molecular masses of 50 and 37 kD, termed L-form and S-form, respectively. NEGR1/Neurotractin participates in the regulation of neurite outgrowth in the developing brain, and is expressed on neurites of primary hippocampal neurons. Neurotractin/KILON is a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation. KILON (kindred of IgLON) and opioid-binding cell adhesion molecule belong to the IgLON subgroup of immunoglobulin superfamily together with the limbic system-associated membrane protein and neurotrimin. The alteration of modulatory function of KILON/NEGR1 for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. In addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.


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Barcelona has signed promising midfielder Thiago Alcantara to a two-year contract extension that ties him to the Spanish champion until 2015.
Barcelona did not reveal terms of the deal, which sees the 20-year-old's buyout clause set at 90 million ($127 million).
Thiago scored an audacious 40-meter free kick in last weekend's 2-0 victory over Switzerland to clinch the European Under-21 Championship for Spain.
Thiago has been used sparingly by coach Pep Guardiola over the past two seasons but is expected to take on a more prominent role this season. Spanish media is questioning whether Thiago's rise could pose a problem to the European champion's decision to sign Cesc Fabregas from Arsenal.


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Prolific Music Producer K-SOLO is ready with his first offering of 2015. This time, he teams up with Star Rising Street Rapper, CDQ on this new street anthem titled "YAYI".
K-SOLO and CDQ really went hard on this New song, with Pumping Beat and Driving Guitar Hooks, its certified to be a club banger in the coming weeks also rolling on your favourite radio stations.
K-SOLO has also promised his fans to keep churning out Hit Songs this Year as he's getting set to drop another jam in July 2015.
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Pls have being searching for gasz song kolo soke….produced by dtunes
nice one
Nice onee tho!


text: Google has recently given its Israel office a complete makeover. The Tel Aviv division of Google has called in the renovators, but this being uber-cool Google they have not just called in any old handymen. Instead noted Swiss design firm Camenzind Evolution has weaved its magic wand over the 85,000 sq. ft. space. The office already looks the part; located in the Electra Tower it gives stunning views across the city and the Mediterranean Sea. The new office design features plenty of "communication landscapes," areas in which employees can casually get together and collaborate, innovate, and communicate with each other.


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Newcastle, England. Kitchen installer Neil and footballer's wife Stevie fall in love. Several problems, though: they're both involved in loveless relationships, their best friends can't stop shagging each other and Neil is about to become adoptive father to a young African girl. Can true love run smooth on the banks of the Tyne?
How to make a successful British romcom: Rule #1 - cast Hugh Grant. And, as Mr. Hugh doesn't appear in The One And Only (the latest movie from East Is East producer, Leslee Udwin), it's clear that it's fighting an uphill struggle from the start.
A pity, really, as the script by Peter Flannery, who wrote Our Friends In The North, expertly combines pathos and broad humour. But his fellow OFITN alumni, Cellan Jones, betrays his TV origins with flat, unimaginative direction.
The performances are good, though Roxburgh - sporting a spot-on Geordie accent, not bad for an Aussie - and Waddell have a complete lack of chemistry, a distinct no-no for any rom-com.
While Newcastle is a perfectly lovely city, there's a reason why it has successfully framed bleak thrillers like 'Get Carter' and Stormy Monday rather than light romances. You'll be pleased to learn, though, that Chesney Hawkes' song of the same name doesn't feature. That's almost worth an extra star. Almost.
A good script is largely wasted in a movie which might have been better served cropping up on BBC2.


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|Guy Incognito <dnd1...@gmail.com>
|indexes from CassandraSF
|Thu, 10 Nov 2011 19:34:44 GMT
hi, i've been looking at the model below from Ed Anuff's presentation at Cassandra CF (http://www.slideshare.net/edanuff/indexing-in-cassandra). Couple of questions: 1) Isn't there still the chance that two concurrent updates may end up with the index containing two entries for the given user, only one of which would be match the actual value in the Users cf? 2) What happens if your batch fails partway through the update? If i understand correctly there are no guarantees about ordering when a batch is executed, so isn't it possible that eg the previous value entries in Users_Index_Entries may have been deleted, and then the batch fails before the entries in Indexes are deleted, ie the mechanism has 'lost' those values? I assume this can be addressed by not deleting the old entries until the batch has succeeded (ie put the previous entry deletion into a separate, subsequent batch). this at least lets you retry at a later time. perhaps i'm missing something? SELECT {"location"}..{"location", *} FROM Users_Index_Entries WHERE KEY = <user_key>; BEGIN BATCH DELETE {"location", ts1}, {"location", ts2}, ... FROM Users_Index_Entries WHERE KEY = <user_key>; DELETE {<value1>, <user_key>, ts1}, {<value2>, <user_key>, ts2}, ... FROM Indexes WHERE KEY = "Users_By_Location"; UPDATE Users_Index_Entries SET {"location", ts3} = <value3> WHERE KEY=<user_key>; UPDATE Indexes SET {<value3>, <user_key>, ts3) = null WHERE KEY = "Users_By_Location"; UPDATE Users SET location = <value3> WHERE KEY = <user_key>; APPLY BATCH
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Running Time: 82 minutes
Released: 08/2016
Studio Name: Marc Dorcel
Director: Philippe Soine
Description: These three Belgian sluts just love to fuck strangers.
4 Scenes from Alice Tapine
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Starring: April Paisley ... More Details
Stars: April Paisley
Sex Acts: Oral Sex, Deep Throating, Vaginal Sex, Handjob, Masturbation, 3-Way
Positions: Kneeling, Laying, Sitting, Standing Missionary, Standing Doggy Style, Standing Side Saddle
Settings: In Vehicle
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Starring: Avril Dance ... More Details
Stars: Avril Dance
Sex Acts: Oral Sex, Handjob, Masturbation, Breast Play, Stripping
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Settings: Woods/Jungle
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Starring: Laure Rosenoire ... More Details
Stars: Laure Rosenoire
Sex Acts: Oral Sex, Vaginal Sex, Handjob, Masturbation, Breast Play, 3-Way
Positions: Laying, Sitting, Standing, Standing Missionary, Standing Doggy Style
Settings: In Vehicle, Forest
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What to do when your bored? Here we came up with Have you ever been stuck at a place, especially your home or office and felt that you are bored? Sitting at home is not only unproductive, but it is even boring. So, the best way for getting rid of the boredom is to do something which you have been putting off for long or challenge yourself for a task which you haven't done before. In the end, we have innumerable things to do when we are bored. Some are creative while some are wacky, some are productive while some are weird or some are just for fun.
It is really boring to get stuck at home and doing nothing. It is favorite tough to keep yourself busy doing something interesting at home. Boredom and pain are the two enemies of happiness. There are few people out there who think that boredom is a blessing for them, especially those people who are always in a hurry and their free time becomes the real torture. So, do you have any idea how to fight this horror of spending your time doing nothing? Do you have any idea about what to do when you are bored? Today we are here with few things to do when your bored, both outside and inside your home.
What to Do When Your Bored At Home?
Here I'm sharing best things to do when bored at home! Check out the answer for what to do when bored!
- You can watch an engaging movie to fight against boredom while being at home. It is one of the best things to do when bored. You can simply go through your old movie collection or search for a new one which you might like. Just grab your popcorns with a cold drink and settle yourself on your couch and enjoy the movie.
- You can even try exploring YouTube, which is one of the best places for browsing the videos. No matter, what your mood is, YouTube has got all the answers and gives your something interesting to watch. People post new videos every second on YouTube, so there is always something interesting and new to watch.
- One of the best things to do when you're bored at home is to listen to music because you are alone at home and it's a great chance for you to listen to favorite songs without any interruptions. You no matter what type of music you want to listen, you just have to sit on your couch, relax and enjoy.
- When we think about the things to do when bored, one thing which strikes our mind is the video games, which are favorite something fun to play with. You can play video games online and spend your time by entertaining yourself.
Check: Things to Do, To be Happy in Unhappy Times
- If you love writing, then it is the right time to explore a writer in you. Spend some quality time with your thoughts and express your feelings. It is just to fight alone against the boredom when you are home alone.
- One of the best things to do when you're bored at home is to try our hands at drawing or painting. Art is one of the best ways to express your thoughts and feelings. So, just grab the supplies and start making some art out of it. Believe us; it is really a fun thing to do.
- You can decorate your room and keep it fresh. Isn't it a fun way to enjoy and have fun when you are home alone. You can rearrange the things or furniture in your room and check what looks the best.
- You can try your hands with cooking. It is one of the best things to do when bored at home. Cook something tasty and exciting rather than relying on the boring, pre-made food.
- If you are confused about what to do when bored, then you can try out the best way to pass your time favorite, and that is, reading. You can read as much as you can, or you can read your favorite magazine.
What to Do When Bored Outside the Home?
Searching for what to do when your bored or what to do when you are bored? Here are few more things to do when bored, check them out!
- One of the best things to do when your bored is to do sports. It easily kills the boredom as well as keeps your fit. You can choose your favorite sporting activity.
- You can go for an adventure somewhere like hiking, biking with friends or drive somewhere at a distance. You can bike around the new towns and visit new places.
- If you are an animal lover, then you can help at the animal shelter. You can go for volunteering and care for the pets. It is one of the best time to spend with the animals.
It is right said by H.G. Wells "There comes a moment in the day when you have written your pages in the morning, attended to your correspondence in the afternoon, and have nothing further to do. Then comes that hour when you are bored; that's the time for to come up with something interesting and exciting in your life."
You might have heard someone saying "I am Bored" or you must have used these words when you are stuck at home on the boring days. When someone murmurs these words, just give them two options, first, some of your work is still pending and second, you must find something to do. These two options are the best ones to recommend because we always have something to do at home. And here, we just have to give a little effort to our brain to think about it. We have already listed some of the best things to do when you are bored, but there are few more which you can do at an appropriate time.
Things to Do When You Are Bored at Work
There might be a possibility that you have finished a big project before the deadline and you have some time to spare, or you might not have many responsibilities like your colleagues. No matter what the reason is, but you are feeling bored at work. So, do you know what to do when your bored at work? Instead of wasting your time on Facebook or chatting, you must put yourself into good use. Time is the biggest resource with high monetary value and the major symptom that you are wasting your precious time is the boredom.
So, it is the right time to take advantage of the whole situation and do something productive, like recognizing your current strategies or taking up new projects or initiatives or developing your professional skillset. It will just help you in making yourself valuable, and thus, you will be able to put yourself in a respectable position. So, here you have got an answer to your question "what to do when your bored at work?"
- It is obvious that your company have a blog so that you can write a blog post. Search for the most suitable topic for your company's blog and write something valuable. You can simply write about your area of expertise or any upcoming event in your company. This way you can help your company with its inbound marketing or SEO campaign as well as in building your personal brand.
- The webinars go on all the time, and 99% of them are for free. So, you can look and search around the websites according to your field of expertise and sign up for them. You can try in developing a new skill, or even you can check out the webinar of the competitor to check your industry's perspective. Just try to get out of your way to learning something.
- One of the best things to do when your bored is to research for the new trends. Just try immersing yourself into relevant news associated with your industry and come up with new ideas.
There are numerous options which are worth exploring. So, you a don't have to be bored if you don't want to be bored. Stay right there, where you are and explore the things. These are the few things to do when bored at work and the best part is that these can help you in a promotion or raise in salary as well.
Few More Things to Do When You Are Bored
- You can try hosting or throwing an indoor picnic. If you think that we will ask you to invite your friends, then no, we would not ask you that because it is you who can kill your boredom. Set up your home and room as a basket of food and a picnic blanket and enjoy having a fun-filled evening.
- You can try your hands on with playing guitar or singing your favorite songs or enjoy having karaoke time. You can invite your family and friends and enjoy having fun, lots of laughter.
- If you want to spend your day and kill your boredom calmly, then the best way is to do a puzzle. The best part about puzzling is the happiness after seeing the finished product.
So, whenever a question pops up in your mind, "what to do when your bored," just try out these best things to do when you are bored. Share your experiences with us.


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Discussion in 'Styling and Customization Questions' started by Stuart Wright, May 24, 2013.
Our site is set to 1000 pixels fixed width.
I see that Xenforo likes 976 pixels by default.
Mine is 992 which is about the limit for a 1024 screen with vertical scrollbar.
I use 992px fixed width. That's the max you can use for iPad.
Edit: ninja'd again by Brogan
I always use 960 for my fixed-width pages... it just seems a nice compromise for the various screen resolutions.
So 992 means the iPad doesn't have to scale it? There's some merit to using that.
If width > 992, there will be a horizontal scroll at the bottom.
No there won't. Our site is 1000 px wide and the iPad just scales it.
Depends on the style and how you set up min-width, width variables.
So why did Mike/Kier pick 976?
It is/was a common grid though I forget why.
I generally prefer 960px myself.
Separate names with a comma.


text:
|The George Washington University
School of Engineering and Applied Sciences
Department of Electrical Engineering and Computer Science
Interactive Data Structure Visualization Courseware
Dr. Duane J. Jarc
Dr. Michael B. Feldman
The Interactive Data Structure Visualization courseware consists of a collection of Web pages together with a Java applet. This courseware contains eleven lessons that are designed to accompany an introductory data structure course, particularly one taught in Ada 95. These lessons pertain to the topics of binary trees, graphs and sorting.
This courseware has been used to evaluate the role of Web-based courseware in the introductory computer science curriculum and to investigate the effect of interactivity and the importance of student learning styles. The results of the first study were presented at the SIGAda '98 conference.
This research was the topic of Duane Jarc's doctoral dissertation. His dissertation provides details concerning the design of the courseware and the results of both of the empirical studies.
We invite your comments about this courseware, particularly any problems that you experience using it, or any suggestions on how it might be improved.


text:
Swann NHD-817 Pan-Tilt-Zoom Home Security Dome Camera3311695 840236110896
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Featuring a versatile and easy-mount design, the Swann NHD-817 Pan-Tilt-Zoom Home Security Dome Camera provides high resolution video recording for all-day surveillance anywhere at home. Integrated with 4x optical zoom, this home security camera is capable of delivering close-ups on details such as faces or license plates.
Key Features
- The Swann NHD-817 Pan-Tilt-Zoom Home Security Dome Camera features a weather-resistant construction, making it durable for both indoor and outdoor installation.
- Its powerful night vision lets the security camera capture footage up to 50m away.
- Recording blind-spots are avoided, thanks to the dome camera's 360-degree rotation capability.
- The Swann NHD-817 camera has multiple preset viewing points, letting you focus recording on key areas immediately.
- Watch live camera footage on your compatible smart device through the SwannView Link app.
This camera can only be used in combination with Swann's 1080p & 3MP Network Video Recorders including 7400 or 7300 series for cutting-edge IP surveillance in full HD (sold separately).
What's In The Box?
- 1x Swann NHD-817 Pan-Tilt-Zoom Home Security Dome Camera
- 1x 30m Cat 5E Ethernet & Power Cable
- 1x Wall & Ceiling Bracket Mounts
- 1x Power Adapter
- 1x Set of Mounting Screws & Plugs
- 1x Set of Theft Deterrent Stickers
|Barcode (GTIN)
|Product Type
|Security Cameras
|Camera Type
|High Definition (HD)
|Camera Resolution
|Optical Zoom
|4 x
|Manufacturers Express Warranty (months)
If you feel your product has failed a Consumer Guarantee (as defined by Australian Consumer Law) then don't worry you can easily return it to your local Harvey Norman store. We'll even pay for the postage if you live in an area where there is no store. Our returns policy covers any purchased item (conditions apply).
Protect your purchase with Product Care®. Get a brand new replacement if your product suffers an eligible fault through our hassle free support process, plus enjoy a range of exclusive benefits like a product health check and free prints each year so you experience your new product even more.
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Ario Pharma Commences Phase IIa Trial of TRPV1 Inhibitor for Cough associated with Chronic Obstructive Pulmonary Disease.
Cambridge, UK, 11 February 2014. Ario Pharma Ltd, the Cambridge biopharmaceutical company developing innovative new approaches to treat respiratory disease, announced today that it has commenced a Phase IIa study of its TRPV1 antagonist, XEN-0501, for the treatment and prevention of cough in patients with chronic obstructive pulmonary disease (COPD). Persistent cough in COPD and other respiratory conditions present as a huge unmet medical need, with novel therapies urgently needed to improve the quality of life of patients.
The study is led by Dr Jacky Smith, Reader and Honorary Consultant in Respiratory Medicine (Principal Investigator) and Professor Dave Singh, Professor of Clinical Pharmacology and Respiratory Medicine (Co-investigator), both based at the University of Manchester. The study is being conducted at the Medicines Evaluation Unit Ltd, University Hospital Manchester NHS Foundation Trust, Manchester. Patients with COPD associated with a history of persistent coughing will be assigned to receive XEN-D0501 or a placebo in a randomised, double-blinded, cross-over study.
XEN-D0501, a potent and selective small molecule inhibitor of TRPV1, has successfully completed multiple Phase I studies and been shown to be safe and well tolerated. The frequency of coughing will be assessed in treatment and placebo groups throughout the study using validated ambulatory cough monitoring technology developed by Dr Jacky Smith. Approximately 22 patients are anticipated to be enrolled into the study and initial results are expected to be analysed and available for release during Q3 2014.
Ario Pharma also announces Professor Maria Belvisi from the National Heart and Lung Institute, Imperial College London, has been appointed as Chief Scientific Officer. Professor Belvisi is an internationally recognised expert in the respiratory field with both pharmaceutical industry and academic research experience. She has received numerous honours and awards for her research into the cellular and molecular mechanisms of asthma, COPD and cough.
Dr John Ford, CEO of Ario Pharma, commented: "Heightened sensitivity of pulmonary TRPV1 channels in COPD is well known, but this is the first time an oral TRPV1 inhibitor has been tested for efficacy in preventing cough in COPD patients. We are very pleased to begin evaluation of XEN-D0501 in patients. We are also delighted to welcome Maria Belvisi as Chief Scientific Officer. Maria is already a member of Ario Pharma's Scientific Advisory Board, and in her new role will become more deeply involved with the company."
For more information, please contact:
Vicky La Touche-Price
+353 1 6334028


text:
The Man-biting Activity of Phlebotomine Sandflies (Diptera:Psychodidae) in a Tropical Wet Forest Environment in Colombia
University of Wisconsin, 1977 - 474 pages
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53 pages matching Buenos Aires in this book
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Common terms and phrases
abundant anthropophilic axis based on modified bifoliata biting activity Buenos Aires catch periods Chaniotis clearing catches clearing habitats CM CM Colombia comparisons crepuscular detected Diptera Entomol epiphytes Fairchild and Hertig forest and clearing forest catches forest floor forest species geometric mean catch gomezi ground level Haddow haematophagous hartmanni located Lutzomyia magnitudes of biting man-biting activity man-biting catches mature forest microenvironments modified geometric mean multiple comparisons occurred ordination Osorno Osorno-Mesa Panama panamensis patterns of biting patterns of man-biting phlebotomine sandflies pioneer vegetation primarily Providencia forest Providencia region Providencia study area Psychodidae rH rH rH Rio Anori rotundipennis secondary forest series of catches six clearing sites species combined species taken specimens Summary temporal patterns Table II-23 tended three forest sites tintinnabula Tiroteos forest Tiroteos sites trapidoi trees Tropical Wet Forest understory understory catches variation vertical stratification Young l97l yuilli


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Skip to comments.Pre-Market Selloff Gathering Steam, European Banks Tanking, Here We Go Again
Posted on 08/10/2011 6:15:14 AM PDT by blam
Pre-Market Selloff Gathering Steam, European Banks Tanking, Here We Go Again
Joe Weisenthal
Aug. 10, 2011, 8:45 AM
After a quiet start to the day, markets are diving again in the early going here.
Dow futures are off 160.
NASDAQ futures are off 1.8%.
Europe, which had been rallying earlier, is seeing selling across the board.
All the Italian banks are getting smashed.
Stomach turning.
(Excerpt) Read more at businessinsider.com ...
"Investors in Italian banks didn't get the memo that the FOMC is saving things."
I just do not understand the fools on wall street, just what is wonderful about the united states dollar being so weak it commands no rent. If you have an truck load of it you could not get enough interest to buy fuel for the truck.
Bloomberg or Drudge (not sure which) referred to the markets as bi-polar. Down 600, up 400, today?
Me thinks someone is messing with the market....up over 600 points in the space of two hours? Don't think so.....
Remember that we read that 70% of all trades are now initiated and made by computer programs.
Many stocks are only held for micro-seconds before they're traded again.
As I watch these huge triple digit swings in the markets, I can't get the images of "Galloping Gertie", aka the Tacoma narrows bridge that swang wildly from side to side before crashing.
As I watch these huge triple digit swings in the markets, I can't get the images of "Galloping Gertie", aka the Tacoma narrows bridge that swang wildly from side to side before crashing.
All the buzz this morning is about France.
The Cac-40 is tanking, Soc-Gen is off over 10%, and the raters, like Moody's are out re-affirming its AAA.
The DJIA opens down 177.
Watch the amazing "Gallopin' Gertie" November 7, 1940 film clip.
1940 Tacoma Narrows Bridge
Slender, elegant and graceful, the Tacoma Narrows Bridge stretched like a steel ribbon across Puget Sound in 1940. The third longest suspension span in the world opened on July 1st. Only four months later, the great span's short life ended in disaster. "Galloping Gertie," collapsed in a windstorm on November 7,1940.
The bridge became famous as "the most dramatic failure in bridge engineering history." Now, it's also "one of the world's largest man-made reefs." The sunken remains of Galloping Gertie were placed on the National Register of Historic Places in 1992 to protect her from salvagers.
so yesterday's bounceback was all Plunge Protection Team fakery I take it?
Heading for 300 down in first five minutes.
More likely, it was highly-concentrated High Frequency Trade (HFT) algorithms bouncing the market up and down violently in the absence of real, long-term investment volume. The "PPT" is really more fiction than fact, which is not to say that the Fed does not intervene in the equity markets at times.
So Bernanke's promise of free money for the next two years may not be enough to stem the oncoming tide!
Maybe if Bernanke offers to pay people to borrow money.....
After all - promising low, or no, interest is just backdoor Quantitative Easing anyway.
Fire up the printing presses and keep them churning until Nov. 7, 2012!
Good imagery:
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