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2010 Acura TSX Sedan - Consumer Review
Build Quality
Reliability Value
Build Quality
Reliability Value
1 of 5 people found this review helpful
Worst Car - 4 things that wrong with it
By Bell on
Vehicle2010 Acura TSX Technology Package 4dr Sedan (2.4L 4cyl 5A)
ReviewThis car is the worst car that ever had. 1a. GPS doesn't have the information about speed limit(It is nothing like TomTom or Garmin) 1c. when for example you search for Wendys it gives you Wendys that 2000 miles away 2. Microphone. 2a. This is my 3rd car with Bluetooth, and this is the worst Microphone ever. People hear you very bad; its like you on a very bad speakerphone. 2b. There is a 3-4 seconds delay between when you answer the phone and people starting to hear you. When its cold outside the climate control blows Hot air to the bottom and Cold air to the front vents (and there is no way to close front vents even on manual floor only mode still blows air from front side vent
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text: 2 July 2001 Real men just make it all up Sign up for our weekly email * I was in my local branch of Barnes and Noble at the weekend looking for a birthday gift. My hands hovered over the bestselling Founding Brothers: the revolutionary generation by the renowned historian Joseph Ellis, the winner of this year's Pulitzer Prize for Non-Fiction and an American historian with a curriculum vitae every bit as impressive as that of, say, Baron Dacre of Glanton (aka Hugh Trevor-Roper). But then something stopped me. Did I really want to buy a book by a liar, a man who has broken the Ciceronian principle that a historian is someone who must never, ever, utter an untruth? This time last month, Ellis, 57, was at the very top of his profession as history professor at Mount Holyoke College in Massachusetts: a small and exclusive private women's college of the kind that Waspy Americans like to think of as "toney". He had written seven major books that attracted both critical and commercial acclaim; he was an expert who had written for publications such as the New York Times, the Washington Post and the New Republic. His PhD was from Yale, and four years ago he won the National Book Award for his definitive biography of Thomas Jefferson. That year, he also told the Boston Globe that he was thinking of writing a book about his experiences in Vietnam. Er, I beg your pardon, Professor? Yes, Ellis, the man who had been a civil rights worker in Mississippi in 1964 and then a paratrooper with the 101st Airborne Division and a platoon leader in Vietnam in 1965 - whence he returned to join the anti-war movement at Yale. Oh, and he had also been a football hero in his high-school days. Good meaty stuff for the definitive, climactic work that would blend his own experiences with a historical perspective: he had told his students in lectures of the horrible things he had seen in Vietnam, and how it had all coalesced to affect his view of the contemporary world. The problem for Ellis - and a personal tragedy that is blowing his life apart - is that he was inventing many of the details of his private life, lie snowballing upon lie until he was living a life of studious deceit. Ellis never served west of the Mississippi during a period when 59,000 other Americans lost their lives in Vietnam; he could not write the book he had envisaged because he had never been to Vietnam, despite lecturing regularly at West Point. "For me," Ellis said last November, "the teaching side of my life and the writing side of my life are part of the same collective whole." That is precisely what is now worrying even his supporters - that his historical works, to put it bluntly, can no longer be trusted. Last week, once his lies were exposed, Ellis was hardly contrite: "Even in the best of lives, mistakes are made," he said. This phenomenon is hardly unique to America. Trevor-Roper may have grievously misjudged the genuineness of the so-called "Hitler" diaries, but he was not a liar. Yet I could name several British journalists - contemporary historians, as some pompously see themselves - who are always inventing material (no, don't worry, I am not thinking of you, X, nor you, Y - but more of you, Z). Poor Jonathan Aitken, his life governed by extravagant braggadocio, disastrously relied on the mighty sword of British justice to adjudicate on whether he was telling the truth over meetings he insisted never took place. And there are more examples of biographies made up by British people, some of which court rules prevent us from publishing. Yet the Ellis affair is peculiarly American in its outrageousness. In a relentlessly commercial, celebrity-crazed culture, it is not enough merely to be a highly successful academic whose books make a fortune; you have to be a larger-than-life character, a hero not only to your students, but also to the public who buy your books. Thus, unsatisfied with his actual personality, Ellis felt forced to inflate and glamorise his real life. In a society that places such a high premium on heavy salesmanship and shameless bullshit to achieve results, Ellis strayed over the border of self-promotion into a compulsive need to reinvent his own personality and to make the package he offered even more sellable and admired. The greatest exponent of this was Ronald Reagan, who told numerous people (including the Israeli prime minister) that he had been "there" at the liberation of Nazi concentration camps in 1945: all complete nonsense, yet told with unnerving sincerity by The Great Communicator. Even FDR was caught telling porkies. A gruesome memory of the Clinton years was when the body of a former US ambassador to Switzerland was dug up and removed from the Arlington National Cemetery because he not been in the Merchant Marines during the Second World War (as he claimed), but had been a student. The tragedy of such people is that they are so driven that they continue to weave lies about themselves even when they have become highly successful; as many as one in ten such Americans, according to a survey, keeps inventing facts in this way. Why? First, this is a "get away with what you can" culture. Second, whether it is in politics or academe or anywhere else, selling yourself becomes the overriding key to success. Finally, there is the macho factor: men reared on the simplicities and falsehoods of John Wayne movies feel compelled to up the ante to prove themselves men. It was not enough for Ellis or Reagan to be a superb historian or a good actor, so they had to invent fraudulent masculine credentials to live up to the myths of their upbringings - just like that other tough guy who never heard a shot fired in anger, John Wayne. Let's ride off into the sunset, fellas. Andrew Stephen was appointed US Editor of the New Statesman in 2001, having been its Washington correspondent and weekly columnist since 1998. He is a regular contributor to BBC news programs and to The Sunday Times Magazine. He has also written for a variety of US newspapers including The New York Times Op-Ed pages. He came to the US in 1989 to be Washington Bureau Chief of The Observer and in 1992 was made Foreign Correspondent of the Year by the American Overseas Press Club for his coverage. Subscribe from just £1 per issue This article first appeared in the 02 July 2001 issue of the New Statesman, Best of young British More


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CustomerCentric Selling® Releases Application for iPhone and iPad(October 17, 2011)
Atlanta, GA (PRWEB) October 17, 2011
CustomerCentric Selling® (CCS), a proven methodology for predictably improving revenue growth and sales performance, today announced the release of a new iPhone application that is available for download free of charge in the Apple AppStore.
The CustomerCentric Selling® application is compatible with the Apple iOS (operating system) 4.0 or later and works with the iPhone, iTouch and iPad. This new application provides the convenience and power of CustomerCentric Selling® seamlessly through any Apple device, with answers to common sales problems, videos, articles, and updated calendar of events and sales training workshops. An Android version of the CustomerCentric Selling® application will be released later this quarter.
Frank Visgatis, President and Chief Operating Officer for CustomerCentric Selling®, stated, As an iPhone and iPad user myself, we are very pleased to offer this application for all Apple users and followers of the CustomerCentric Selling® sales methodology. The application allows any sales professional to conveniently stay connected with CCS and get answers to common sales questions.
Visit this link in the Apple AppStore to view screenshots and download the free application: http://itunes.apple.com/br/app/customercentric-selling-pocket/id459462258?mt=8
About CustomerCentric Selling®
CustomerCentric Selling® (CCS) is a proven methodology for predictably improving revenue growth and sales performance. Founded in 2002, CCS helps clients worldwide to implement repeatable, auditable and scalable sales processes that, when combined with Sales Ready Messaging®, guides marketing and sales to have meaningful conversations with customers and prospects. This results in winning high-value deals, retaining and growing client relationships and improving the predictability and accuracy of sales forecasts.
CustomerCentric Selling® has been named to Training Industrys list of Top Sales Methodology Training Companies for 2009, 2010, 2011, and also made Selling Powers Top 10 Sales Process Companies list. Clients such as Microsoft, Hewlett Packard, Business Objects, Rockwell Automation, EMC and Raytheon have deployed CCS sales training worldwide. For more information, visit http://www.customercentric.com or email Jill Perez: jperez(at)customercentric(dot)com or call +1.800.993.1228, ext 706.
# # #
Read the full story at http://www.prweb.com/releases/2011/10/prweb8880680.htm.
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Rising Action Climax Falling Action Resolution Plot Diagram: Exposition:
The background information on
the characters and the setting Rising Action:
Series of events that
lead to the climax
When the conflict of the
plot is resolved Falling Action:
Events after the climax
Tells what happens to the characters after the conflict is resolved
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text: Olivia Claire Hutching (March 25, 1997), credited as Liv Hutchings, is a Canadian actress and dancer from Toronto, Ontario. She portrayed a Little Journalist in the season 8 episode "The Jung and the Restless". External LinksEdit IMDB Link Official Site Retrieved from "http://charmed.wikia.com/wiki/Liv_Hutchings?oldid=287175" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Performers Out of Universe Guest Stars Add category Cancel Save


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Selected from the instrumental, vocal and orchestral repertoire, this piano collection provides a valuable resource of classical music for weddings. It contains quiet, reflective works for use before and
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The sixth volume in the Sunday Morning series, this collection has music for times of celebration, sorrow, and sacrament. Victor Labenske has included standard wedding pieces arranged with his
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Adoption requests → Idle Worship wiki
What is your username?Uzzi21
Please link to the wiki here:http://rbt-rising.wikia.com/wiki/MediaWiki:Communitymessages-notice-msg
How many edits have you made on that wiki?11
How many days/months have you been editing there?Since 6 days
On the Special Pages -> Special:ListUsers when was the last time an admin edited, and who was it?It was me.
Any other information:No
- Hi. I'm afraid I do not understand your request; you founded the wiki and already have admin and bureaucrat rights. If you have an issue with your wiki, please send a message to Special:contact. -- Wendy (talk) 02:28, January 18, 2013 (UTC)


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If you are not 100% satisfied with your purchase, you can return your order to the warehouse for a full refund (Bottles must be unopened, in the state you received them, and in the original packaging). We believe that in order to have the best possible online shopping experience, our customers should not have to pay for domestic return shipping. So if you're not happy with your purchase, just contact us right away and we will provide you with details for returning the unopened bottles - your domestic shipping costs are prepaid by us.
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This quirky, air-conditioned city hotel has 24 themed rooms based on famous couples and romance. Guests are welcomed in the lobby, which offers a 24-hour reception, a hotel safe, fax/photocopying services and a newspaper stand. There is a library in the hotel and guests can enjoy a drink at the café and dine in the restaurant. Wireless Internet access is available and guests can also take advantage of the laundry services.
The hotel is perfectly situated just 550 metres from Anvers Métro station in Butte de Montmartre. The Sacré Coeur Basilica is just 180 metres away and both the Palais Garnier opera house and the Louvre are less than 5 km away. The Moulin Rouge and the Place du Tertre are within a convenient 10-minute walk.
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American Express, MasterCard and VISA are accepted at this hotel.
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Double bed
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Three Palestinians shot dead as Israeli forces raid Bethlehem
Three Palestinians were shot dead late Thursday and early Friday by Israeli troops. In a village west of the West Bank city of Hebron, Israeli soldiers killed a Palestinian, who they had come to arrest Thursday night, Israel Radio reported. In the Gaza Strip, Palestinian sources reported that occupation troops killed two Palestinians near the Dugit settlement.
Later, Hamas announced the two were part of a "national unity" cell composed of activists from Hamas, Fatah and Islamic Jihad. It said the activists were on special mission in Dugit area when occupation troops spotted them and opened fire.
Meanwhile, less than 24 hours after the suicide bombing in Jerusalem that killed 10 Israelis, some 20 Israeli military vehicles entered Bethlehem, in an operation that appeared to destroying the house where the bomber lived, in the Aida refugee camp next to Bethlehem.
Before dawn Friday, Israeli forces instructed Palestinian security officers to abandon checkpoints outside Bethlehem, and troops moved into the town, residents said. After a few hours the occupation forces moved out the city.
Israeli security officials said earlier that Sharon and Defense Minister Shaul Mofaz met late Thursday to discuss retaliation options.
In Ramallah area, Israeli forces razed six houses belonging to Hamas activists the army said was responsible for an attack at Ein Yabrud in which three soldiers were killed, according to media report.
On the diplomatic front, United Nations Security Council diplomats failed to agree on a statement condemning the suicide bombing in Jerusalem on Thursday. Israel called that failure "outrageous."
Council diplomats said three hours of closed-door negotiations fell apart when Algeria, the only Arab nation on the council, insisted that any statement must also condemn the deaths of eight Palestinians in an Israeli incursion into Gaza City on Wednesday.
© 2004 Al Bawaba (www.albawaba.com)
Top Headlines
- Israeli troops shoot unarmed Palestinian teen dead in Bethlehem
- Israel\'s Security Forces Arrest Three Palestinians in Bethlehem
- Israeli Air Raid Destroys Houses near Bethlehem, Wounds Three Palestinians
- Four Palestinians, Israeli officer killed in West Bank and Gaza Strip; Tanks raid Bethlehem
- Algeria: Eight troops shot dead


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Hamilton or Toronto2/Markham
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Location: Guelph, ON
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Originally Posted by
Consider the 2006-11 intercensal population growth between the Hamilton-Burlington CMA and the Kitchener-Cambridge-Waterloo CMA.
From 2006-11, the Hamilton-Burlington CMA grew from 692,911 to 721,053, a growth of 4.1%. Most of that growth, of course, is attributable to Burlington, which is also considered to be a part of the GTA and is in that region in between Toronto city and Hamilton city.
From 2006-11, the Kitchener-Cambridge-Waterloo CMA grew from 451,253 to 477,160, a growth of 5.7%.
If you look at the Government of Ontario's population projections from the 2011-36 period, this difference in growth is expected to further diverge.
Firstly, the Government of Ontario considers both the Hamilton CMA and the Kitchener CMA to be in Central Ontario.
With respect to Central Ontario, the Government of Ontario predicts that:
"The population of Central Ontario is projected to grow by 814,000 or 28.2 per cent, from 2.89 million in 2011 to 3.7 million in 2036. The regions share of provincial population will decline slightly from 21.6 to 20.9 per cent."
So the entire region will grow, but it's population share will decline. This decline is almost entirely attributed to the projected growth of the GTA.
Within Central Ontario, the Government of Ontario further predicts that:
"Three census divisions surrounding the GTA will continue to experience population growth significantly above the provincial average; they are Simcoe at 42.7 per cent, Waterloo at 41.8 per cent and Dufferin at 34.3 per cent."
Do you notice the absence of Hamilton from this list? When you calculate the percentage of growth predicted in these three census divisions, it becomes apparent that the growth in absolute numbers in Central Ontario and the only thing forestalling a rapid decline in the population share of Central Ontario are these three census divisions.
In terms of an ideal location to serve Southern Ontario outside of the GTA, the Kitchener CMA is on the border of Central Ontario and Southwestern Ontario. It is in between Hamilton and London, two towns with not insignificant populations. Compared to Hamilton, the main disadvantage is that it cannot draw from the Niagara region. But really, that should be considered a positive point because it allows Kitchener to sidestep the whole concern of Buffalo and how it draws some of its fanbase from the adjacent Niagara region.
Of course, I am not saying that the KW region can support a team today. I'm saying that I'd prefer to put a team in Markham now, and if another team is needed in Southern Ontario, I'd wait a couple of decades and put it in the KW region. Of course, Mississauga would also be a more immediately available option.
Moreover, if we are talking about the OP's comparison between Hamilton and the GTA, the Government of Ontario further predicts that:
"Within the GTA, Torontos population is projected to rise from 2.74 million in 2011 to 3.42 million in 2036, an increase of 24.5 per cent, below the provincial growth rate of 32.7 per cent.
Growth in the other census divisions of the GTA (Durham, Halton, Peel and York) will be significantly faster than the Ontario average, with the addition of over 2.1 million people to the suburban GTA.
Now, you can make race-based generalizations and say the "demographics" of York Region will not work out. This ignores the fact that, of course, in absolute numbers York Region has more white people than the Hamilton CMA. Moreover, a Markham team would be a "north of Toronto" team, and a "north of Toronto" team would encompass both York Region and Simcoe Region. If you refer back to the previous prediction about Central Ontario's growth, you will see that Simcoe Region is one of the few census divisions in Central Ontario that are expected to grow at a pace comparable to communities in the GTA. Simcoe Region, FYI, is north of Toronto; it borders York Region.
lots of numbers here.
yes, most people here are familiar with the
places to grow
mandate and yes, some areas are being forced to grow more than others .... but ...
1) you assume that population growth is all good. well, it is not. indeed, forced growth is very dangerous. opponents of
places to grow
correctly raise concerns about tenuous financing structures which will need to pay for forced infrastructure. existing property tax revenues cannot support these new expenses, the province has not been terribly generous, and forget about local industry tax revenue ... cities will be handing out incentive cash for decades to lure businesses into their regions, so gone are the days of healthy, mixed regional revenue sources. the game has now irreversibly changed when it comes to municipal financing.
currently, guelph is also being forced to grow well above its capacity and it is actually considering closing some pools and draining fountains because it simply cannot afford to build the sewers and roads it is being ordered to build by the province today. insanity on guelph council aside, things will only get worse. dont expect that KW or milton or any other place near the top of the growth rate chart will be able to afford even basic services, let alone chip in for a new NHL arena. it just wont happen. kw will be hard pressed to keep up with the costs of growth and it wont have a few hundred million laying around to buy a new arena. (as well, consider that it is k and w, two jurisdictions, ripe for contentious disagreement)
2) your numbers incorrectly assume comparability between regions with respect to mobility. KW does not, nor ever will have a dense urban core like the hammer. that's not the way that city evolved, nor is it the plan. KW is sprawl. moreover, KW is surrounded by smaller quaint hamlets, literally out in farmers fields. true, some will be swallowed by sprawl, but it is silly to think that folks in the golden triangle (kw, camb and guelph) are equally mobile to an arena in KW compared to folks in the GHA and Copps.
bet you dollars to donuts that someone in guelph would be no more likely to attend a game in KW than to attend one in the hammer ... ie., not that likely, especially in winter. so, you can take the forecast population numbers and immediately cut them in half because that many people are so far away from the urban core (or wherever an area might be built) that they are very unlikely to attend games. hamilton, on the other hand is already dense. and a much higher proportion of residents are within 25 minutes drive of Copps than will ever be within similar driving distance from any KW arena, despite growth figures.
and 3) you touch on demographics, but I think you fail to recognize the rabid interest folks in the hammer have in getting an NHL team. it will sell out just as fast as winnipeg (in fact, it has already). no such guarantee would exist in kw, especially if you assume it would draw from much further, inconvenient driving distances in surrounding areas. you think toronto is boringly conservative? kw is ten times that boring.
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Dahlia Rizk, MA, LCMHC
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When a couple seeks counseling they often feel hopelessly stuck in the same unhealthy communication patterns, feelings of estrangement and distance, and a lack of emotional closeness. Sometimes one person in the couple wants counseling but the other refuses to seek help. Couples counseling can be beneficial to your relationship with both people in session as well as with only one person willing to come in. Doing one thing different will change your relationship. Call me and lets discuss the changes you want to see and how to make them happen.
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About this Article
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Conflict and Compromise in American Religious Politics: A Review Essay
DAVID O'CONNELL reviews two new books on religion's role in American politics, Mark A. Smith's Secular Faith: How Culture Has Trumped Religion in American Politics and Neil J. Young's We Gather Together: The Religious Right and the Problem of Interfaith Politics. He argues that these works of scholarship show us how people of different religious and moral beliefs are not as politically divided as one might think.
About PSQ's EditorDemetrios James Caraley
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Tactical Advantages of Terror
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Build a Dating Website
Orçamento €1500-3000 EUR
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132 freelancers estão ofertando em média €2765 para este trabalho
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text:
New Jersey Teen Asks Girlfriend to Prom in a Unique Way [VIDEO]
Subscribe to Cat Country 107.3 on
Derk sings in an Acapella Quartet called The Whiptones. He gathered his follow quartet members to help ask his girlfriend to prom!
And the whole proposal was caught on tape!
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text:
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First con and looking for roomates! (topic)
Hi my name is tanika. Iv been wanting to go to the cons since i found out about them at age 16. Now age 24 im finally gonna spurge on myself and go. Im flying all the way from ohio and iv never been on a plane so im a little worried...
|Convention Hall
Xena: Warrior Princess is a copyright and trademark of NBC Universal Television Holdings LLC. No infringement intended.
Xena Online Community copyright © 1999 - 2014


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|"Uma Maheswara Rao G (JIRA)" <j...@apache.org>
|[jira] [Commented] (HDFS-1971) HA: Send block report from datanode to both active and standby namenodes
|Mon, 22 Aug 2011 14:26:29 GMT
[ https://issues.apache.org/jira/browse/HDFS-1971?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=13088725#comment-13088725 ] Uma Maheswara Rao G commented on HDFS-1971: ------------------------------------------- Hi Sanjay, Thanks for posting the document!. Looks solution 1 will be good and simpler. Here i have some questions. Assume one scenario, if DN contains a block and related file is not yet closed by client. So, that block information may not be available in standby node. When we send the block reports from DN to standby, it may give the command to DN as invalidates as that block information is not avalible in standby. When it receives the invalidates command from standBy node,what is the action in DN? Whether we will ignore the block invalidate commands from standBy node? --Thanks > HA: Send block report from datanode to both active and standby namenodes > ------------------------------------------------------------------------ > > Key: HDFS-1971 > URL: https://issues.apache.org/jira/browse/HDFS-1971 > Project: Hadoop HDFS > Issue Type: Sub-task > Components: data-node, name-node > Reporter: Suresh Srinivas > Assignee: Sanjay Radia > Attachments: DualBlockReports.pdf > > > To enable hot standby namenode, the standby node must have current information for - namenode state (image + edits) and block location information. This jira addresses keeping the block location information current in the standby node. To do this, the proposed solution is to send block reports from the datanodes to both the active and the standby namenode. -- This message is automatically generated by JIRA. For more information on JIRA, see: http://www.atlassian.com/software/jira
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HM Revenue and Customs is struggling to finish thousands of tax investigations into suspected tax avoidance by the UK's largest companies. Nick Huber reports.
HMRC's large-business service, which deals with the tax affairs of the UK's 770 largest companies, had 2,314 unresolved enquiries into the companies' tax affairs on March 31, according to figures released to Accounting WEB under the Freedom of Information Act.
Around one third (737) of the unresolved enquiries at the large-business service are more than three years old...
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text: This bag is made by Matt & Nat from vegan materials. It features a removable cross body strap, top zipper closure, a zipper pocket, and a smartphone pocket. Dimensions: 10.5" x 7.5" x 4." Shoulder Strap Drop: 22." Handle Drop: 3. Matt & Nat is a vegan bag manufacturer that uses renewable and recycled materials, like the cork tag and 100% recycled nylon lining.


text:
I was former asked to criticism a 100 leaf conglomerate outline for a patron that needful to employ for funding to start on a multi-million monetary unit health care provider ensemble. Most bankers would have inverted behind the human for funding because the company line of attack was crammed of jargon, written in extremely method language, and firm to have a handle on. The prototypic 40 pages of the aim were confused and radius in mass position. They did not visibly carry what the loan pretender was testing to supply or how they planned to make revenue to pay stern the loan. There was no perceptibly definite company strategy or commerce develop. There was of late a lot of info about the medical/homeopathic results of severely industrial research. To say the tiniest the business organisation line of attack didn't even have an first night notional to keep posted the reader of the key points of the text.
Well into the 2nd fractional of the company scheme I completed that all the key subject matter a supporter of necessity to make an familiar conclusion around approving funding was hidden cavernous within. But would the supporter have ready-made it to this ingredient of the document? Probably not. Banks are overpowered with debt applications all day and to ask mortal to go through with a written document that doesn't even have an abstract is a lot to ask of someone.
The essayist of this preceding business idea had singular one possibleness to variety a plausive primary opinion and to get the cash in hand indispensable to launch his firm. If the scholarly person (the loan's military personnel) did not act well to the document, the journalist would possible ne'er be welcome to intuitively send the communication he had been exasperating to move on composition. Even conversely he was highly qualified in his field, his business thought did not offer that idea. It didn't festival that he had the commercial apprehension or administration skills essential to gloriously run a multi-million dollar friendship.
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text:
Find a copy in the library
Finding libraries that hold this item...
|Criticism, interpretation, etc
|Named Person:
|Laura (Riding) Jackson; Laura (Riding) Jackson
|Material Type:
|Government publication, State or province government publication
|Document Type:
|All Authors / Contributors:
Laura Riding; Lisa Samuels
|0520213947 9780520213944
|OCLC Number:
|Originally published: London : Jonathan Cape, 1928.
|lxxviii, 274 pages ; 21 cm
|Creating Criticism: An Introduction to Anarchism Is Not Enough --
Laura Riding: A Chronology --
The Myth --
Language and Laziness --
This Philosophy --
What is a Poem? --
A Complicated Problem --
All Literature --
Mr. Doodle-Doodle-Doo --
An Important Distinction --
The Corpus --
Poetry and Music --
Poetry and Painting --
Poetry and Dreams --
Jocasta --
How Came it About? --
Hungry to Hear --
In a Cafe --
Fragment of an Unfinished Novel --
William and Daisy: Fragment of a Finished Novel --
An Anonymous Book --
The Damned Thing --
Letter of Abdication --
App. I. Three Commentaries on Anarchism Is Not Enough --
App. II. Author to Critic: Laura (Riding) Jackson on "Anarchism Is Not Enough" --
Selected Bibliography of Works by Laura Riding.
|Laura Riding ; edited and with an introduction by Lisa Samuels.
|More information:
"Anarchism Is Not Enough is a manifesto against systematic thinking, a difficult book by a famously difficult writer. For the scope of its critical imagination, it is the most radical work of Laura Riding's early period. Published in 1928, when Riding was twenty-seven, Anarchism is a kind of early autobiographia literaria. Long out of print and now available for the first time in paperback, this is one of the most imaginative and daring works of literary theory ever written by a modernist figure."--Jacket.
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- Jackson, Laura (Riding), -- 1901-1991 -- Philosophy.
- Literature -- Philosophy.
- Meaning (Philosophy)
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- Jackson, Laura (Riding), -- 1901-1991
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text:
The Stanford Court Hotel is a classic boutique hotel. It is located above the Financial District on Nob Hill. The lobby is updated with sleak colors and music. The color coordination of the property and style reminds me of the early Reagan Administration when light colors such as gold, yellow, white, and light blues were in fashion.
The one downside was its cable television. Although my room had a nice flat screen television, many of the stations were not HD and the CNBC reception was spotty where the volume would cut out. The front desk said that this was caused by the rain passing through.
I enjoyed this stay since the hotel is not as overrun with foot traffic as other San Francisco hotels.
- Official Description (provided by the hotel):
- Stanford Court San Francisco is fresh, fashionable and at the center of everything savvy visitors want to see and do. Enjoy sweeping views of the city, the bay and the majestic Golden Gate Bridge from our convenient location atop historic Nob Hill. Discover the best of San Francisco's charm and character while enjoying our contemporary boutique hotel as your home base.An ideal location, we are conveniently situated in Nob Hill close to premier shopping, dining, and attractions in Union Square. We are steps to the historic cable cars, a short walk to Chinatown, Fisherman's Wharf, Union Square and the Ferry Building.393 newly-renovated rooms and suites, offering cool, contemporary accommodations. Three cable car lines running directly in front of the hotel, waiting to whisk you to San Francisco's hottest neighborhoods and landmarks ... more less
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text:
The Purple Ribbon is seen in both Blood and Sand and War of The Damned. The ribbon was tied around Sura's thigh in the The Red Serpent as Spartacus leaves to serve in the Roman auxillary. Following the couple's enslavement, the ribbon was retrieved by Glaber and given back to Spartacus at Batiatus' Ludus.
During his "test" against Crixus, Spartacus drops the ribbon onto the combat platform. He later uses the ribbon to trip Crixus as Crixus stood upon it. Throughout much of his time as a Gladiator, Spartacus wears the ribbon tied around his arm. It serves to symbolize his reason for living: saving Sura from slavery. He is later seen using his scant water ration to clean the ribbon after he and Varro are punished by being thrown into the waste pit.
When Batiatus forces Spartacus to fight in The Pit, Batiatus, knowing the importance of the ribbon, asks that Spartacus remove it lest it be sullied with the stain of dishonor that surely accompanies battling in a place like The Pit. When Spartacus redeems himself from The Pit after saving Batiatus' life, it is returned to him by Batiatus.Spartacus continues to wear it until Sura arrives at the ludus. When she dies of her wounds, Spartacus places it in her funeral shroud and it is burned along with Sura.
Strangely, the ribbon reappears in War of the Damned when Spartacus is speared 3 times by Crassus' men. As he is reeling from the impalement, Spartacus sees the ribbon blowing across the ground and has a reflection to the time when he first tied it around her thigh, many years before.


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A 4-week, dose-ranging study comparing the efficacy, safety and tolerability of latanoprost 75, 100 and 125 μg/mL to latanoprost 50 μg/mL (xalatan) in the treatment of primary open-angle glaucoma and ocular hypertension
Several studies have investigated the effect of latanoprost on intraocular pressure (IOP). We compared the IOP-lowering effects of three higher concentrations of latanoprost with the commercially available concentration of 0.005% (50 μg/mL) in patients with primary open-angle glaucoma or ocular hypertension.
Treatment-naive subjects or those receiving IOP-lowering medication with baseline IOP levels of ≥24 mmHg and ≤36 mmHg in at least one eye after washout were randomized to receive an evening dose of latanoprost 50, 75, 100, or 125 μg/mL for 4 weeks. At weeks 1, 2, 3, and 4, ocular examinations were performed and IOP was measured. Ocular symptoms and adverse events were monitored. The primary efficacy endpoint was the change in IOP from baseline to week 4 at 8 a.m. and 4 p.m. for the per protocol (PP) population using a "worse eye" analysis. Secondary efficacy endpoints were change in IOP at each time point from baseline across all visits, and percentage change in IOP from baseline to week 4 at 8 a.m.
In all, 282 patients were randomized and treated; 274 were included in the PP population. Treatment groups were similar at baseline; 68% were diagnosed with primary open-angle glaucoma. Mean baseline IOP levels were comparable across treatments. There were no statistically significant differences in IOP reductions from baseline to week 4 at either time point between those treated with higher concentrations of latanoprost versus those receiving 50 μg/mL. Least squares mean IOP changes at 8 a.m. were −10.13, -9.59, -10.02, and −9.06 mmHg for latanoprost 50, 75, 100, and 125 μg/mL, respectively, and at 4 p.m. were −8.90, -8.29, -8.81, and −8.34 mmHg, respectively. Results of secondary efficacy analyses supported those of the primary analysis. Conjunctival hyperemia, the most commonly reported adverse event, occurred in 16.9%, 18.6%, 20.8% and 15.9% of subjects receiving latanoprost 50, 75, 100, and 125 μg/mL, respectively.
IOP reductions were observed in all treatment groups postbaseline, with no clinically relevant or statistically significant differences detected favoring any of the higher concentrations of latanoprost compared with latanoprost 50 μg/mL. All doses of latanoprost were well tolerated.
Trial registration
Clinical Trials.gov Identifier NCT01379144.
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy with characteristic changes in the optic nerve head, including optic nerve cupping and thinning of the neuroretinal rim
There are relatively few studies in which the effect of latanoprost dose on IOP has been investigated
Yet, few of these studies had sufficient numbers of patients/subjects for statistical comparisons between groups. In the second Alm study
Study design
This was a 4-week multicenter, randomized, double-masked, dose-ranging, parallel-group study comparing three higher concentrations of latanoprost (75, 100, and 125 μg/mL) with latanoprost 50 μg/mL. This study was conducted in accordance with the International Conference on Harmonization Guideline for Good Clinical Practice and the Declaration of Helsinki and the protocol approved by the independent ethics committees/institutional review boards responsible for each participating institution. Written informed consent was obtained from all subjects prior to enrollment in the study.
Ethics committees/IRBS included Ministerio da Saude Hospitais Civis de Lisboa, Lisbon, Portugal; Ethics Committee of Institute of Aviation Medicine, Prague, Czech Republic; South East Sydney Area Health Research Ethics Committee, Sydney, Australia; Comite Consultatif de Protection des Personnes dans la Recherche Biomedicale, Hopital Tarnier, Paris, France; AIBILI Associacao para Investigacao Biomedica e Inovacao em Luz e Imagem Azinhaga de Santa Coma, Coimbra, Portugal; Solihull Local Research Ethics Committee, Birmingham, UK; East Birmingham Local Research Ethics Committee Birmingham Heartlands Hospital, Birmingham, UK; AKADIMOS Ophthalmology Centre of Northern Greece, Thessaloniki, Greece; Ethics Committee of OSL, Prague, Czech Republic; Aga Khan University Hospital IRB, Karachi, Pakistan; Unidada Local de Saude de Matosinhos, Matosinhos, Portugal; Research Ethics Committee Glasgow Royal Infirmary, Glasgow, Scotland, UK; Sunderland Local Research Ethics Committee, Sunderland, UK; The Layton Rahmatulla Benevolent Trust Free Eye & Cancer Hospital, Lahore, Pakistan; The Ethics Committee of the Faculty of Medicine Cholalongkom University, Bangkok, Thailand; The Ethical Review Committee on Research Involving Human Subjects, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; eticka komise of the General Faculty Hospital, Charles University, Prague, Czech Republic; Royal Adelaide Hospital Research Ethics Committee, Adelaide, Australia; Medical Ethics Committee, Dow Medical College and Civil Hospital, Karachi, Pakistan; University Hospital Brno, Brno, Czech Republic; PGMI/Service Hospital Ethics Committee, Lahore, Pakistan.
Male or female subjects ≥18 years of age with POAG or ocular hypertension requiring unilateral or bilateral administration of IOP-lowering treatment, including subjects who were naïve to such treatment, were enrolled. It was recommended, but not required, that subjects have an IOP ≥17 mmHg and ≤36 mm in at least one eye at screening to be eligible. After a washout period in subjects on prior medications (see "Treatment and assessments" below) subjects were reassessed for eligibility and required to have an IOP ≥24 mmHg and ≤36 mmHg in at least one eye at 8 a.m. at the baseline visit. Exclusion criteria included: closed/barely open anterior chamber angle or a history of acute angle closure; history of discontinued prostaglandin IOP-lowering treatment, unless the reason for discontinuation was participation in a clinical study; ocular surgery or argon laser trabeculoplasty in one or both eyes within 3 months prior to the screening visit; current use of contact lenses; use or anticipated requirement during the study period of topical medication known to affect IOP; anticipated need to modify systemic medication known to affect IOP during the study period; any condition in one or both eyes that would prevent reliable applanation tonometry; ocular inflammation/infection in one or both eyes within 1 month prior to the screening visit or during the washout period; known hypersensitivity to benzalkonium chloride or to any other component of the study medication; other abnormal ocular conditions or symptoms that prevented the subject from participating in the study, according to the investigator's judgment; participation in any other ocular or systemic clinical study within 1 month prior to the screening visit; other severe, acute, or chronic medical or psychiatric condition or laboratory abnormality that, in the investigator's judgment, could have increased the risk associated with study participation or study drug administration, or may have interfered with the interpretation of the study results; uncontrolled systemic disease; women of childbearing potential who were not using adequate contraceptive methods or who were pregnant or nursing.
Treatments and assessments
Subjects were assessed for eligibility at a screening visit that took place up to 4 weeks prior to the baseline visit. At screening, ocular and medical histories and previous and concomitant medications were documented; ophthalmoscopy, refraction, biomicroscopy, and a slit lamp examination (to evaluate hyperemia) were performed; and best-corrected visual acuity (BCVA) and IOP were measured. Conjunctival hyperemia was graded according to a 4-point photographic reference scale ranging from 0 (none) to 3 (severe). Throughout the study, IOP was measured in both eyes (the right eye preceding the left eye) using a calibrated Goldmann applanation tonometer. The measurement was done by two study personnel (an operator and a recorder) as recommended by the guidelines from the Eye Care Technology Forum
Subjects who were receiving IOP-lowering treatment and who met the eligibility criteria entered into a washout period, the duration of which depended on their current IOP treatment (4 weeks for prostaglandin analogs; 3 weeks for beta-blockers [alone or in combination] or oral carbonic anhydrase inhibitors; 2 weeks for epinephrine and dipivefrin or adrenergic agonists; and 1 week for topical carbonic anhydrous inhibitors, pilocarpine, carbachol and aceclidine). Subjects could attend the study site for safety monitoring during the washout period at the discretion of the investigator and/or the subject's choice. For subjects not receiving IOP-lowering medications, the screening visit could be combined with the baseline visit.
At the baseline visit, examinations performed at screening were repeated except for refraction; ocular symptoms and adverse events were assessed; and iris/en face photographs were taken (2 sets for each eye; one retained at the study center and one sent to a central reading center). Baseline IOP was measured at 8 a.m. and 4 p.m. (± 1 h). Subjects were randomized to receive latanoprost 50, 75, 100, or 125 μg/mL in a 1:1:1:1 ratio with a computerized randomization list using the random permuted blocks method. A multiple of the block size (n = 8) was distributed to each study center, where the investigator assigned subject numbers consecutively. Subjects were instructed to instill one drop of study medication in one or both eyes in the evening of the baseline visit between 7 p.m. and 9 p.m. and every evening during the entire treatment period with the last dose administered in the evening of the day preceding the week 4 visit. All concentrations of latanoprost contained the same concentration of benzalkonium chloride (0.2 mg/ml).
Follow-up visits occurred at weeks 1, 2, 3, and 4. At each visit, biomicroscopy was performed; BCVA, conjunctival hyperemia, and IOP were evaluated; and ocular symptoms, adverse events, and concomitant medications were recorded. At least 12 h must have elapsed between administration of the evening dose of study medication and measurement of the morning IOP. At week 4, ophthalmoscopy was performed and iris/en face photographs were repeated. Subjects were contacted by telephone 1 week after the week 4 visit to elicit additional information concerning adverse events.
Adverse events, both observed and volunteered, were monitored by investigators throughout the study. The severity of events (mild, moderate, or severe) and the investigator's opinion concerning whether the event was related to study drug were noted. Serious adverse events were those that were life-threatening, required inpatient hospitalization/prolongation of hospitalization, caused persistent or significant disability/incapacity, or resulted in congenital anomaly/birth defect or death. Adverse events were followed until they resolved or stabilized. Adverse events were considered treatment-emergent if they occurred between baseline and week 4 or if they were present at baseline but increased in severity and/or seriousness during the study.
Endpoints and analyses
Efficacy analyses were performed for both the study eye and the worse eye. The study eye was defined as any eye meeting all inclusion and no exclusion criteria; if both eyes were eligible, the mean value of the IOP recording in both eyes at a given time point was included in analyses. The worse eye was the study eye with the highest baseline 8 a.m. IOP; data from the right eye were used in subjects with two study eyes with equal 8 a.m. IOP levels at baseline. The intention-to-treat (ITT) population included all subjects who received at least one dose of study medication; separate ITT analyses were performed using observed data and using the last observation carried forward (LOCF) method to impute missing IOP data. The per-protocol (PP) population included all subjects who completed the study treatment period without major protocol violations.
The primary efficacy endpoint was the change in IOP from baseline to week 4 (day 28; 8 a.m. and 4 p.m.) in the worse eye, and the primary analysis of this endpoint was conducted in the PP population. Pairwise comparisons of latanoprost 75 μg/mL, 100 μg/mL and 125 μg/mL versus latanoprost 50 μg/mL were made using analysis of covariance (ANCOVA) with baseline IOP as the covariate and center and dose group as factors. A point estimate (least square mean), p-value and a two-sided 90% confidence interval (where the upper limit corresponded to the one-sided test of 5%) for the adjusted treatment differences were calculated. If the treatment effect was not significant, no further models were fitted. If the treatment effect was significant, the model was refitted with terms for treatment by covariate interactions to assess the robustness of the treatment effect across covariates. Standardized residuals were plotted for all models fitted to validate model assumptions. To test the robustness of the results of the primary analysis, analyses were repeated in the PP population for study eyes and in ITT population for both worse and study eyes.
For both worse and study eyes, secondary efficacy endpoints included IOP change from baseline to weeks 1, 2, and 3, analyzed using the PP population, and percentage change in IOP at 8 a.m. 4 weeks postbaseline, analyzed using both the PP and the ITT populations. The statistical significance of pairwise comparisons between latanoprost 50 μg/mL and each higher concentration was tested at each visit and time point using the same model as for the primary efficacy analysis. These efficacy comparisons were one-sided and performed at the 5% level of significance; no adjustment for multiple comparisons was made. The influence of potential prognostic factors (ie, age, gender) on the change in IOP was evaluated using frequency tables for the PP population on the worse eye.
Safety analyses were based on both eyes using the ITT population. Adverse events were classified by system organ class and preferred term using the Medical Dictionary for Regulatory Activities (MedDRA) version 2.3, and treatment-emergent adverse events were tabulated by treatment group. The frequency of cells/flare in the anterior chamber and ocular symptoms was tabulated as was the change from baseline in iris pigmentation and eyelash growth. Hyperemia was assessed using the same scale that was used in the phase III studies of latanoprost (25,28), with 0 = None (no hyperemia), 1 = Mild (reddening of the palpebral or bulbar conjunctiva). 2 = Moderate (bright reddening of palpebral or bulbar conjunctiva) and 3 = Severe (deep, bright, and diffuse reddening of palpebral or bulbar conjunctiva).
The sample size of 240 subjects was based on clinical judgment rather than on formal power calculations. Assuming a standard deviation of 4 mmHg, a study recruiting 50 evaluable subjects per treatment arm would provide 80% power to detect a difference of 2.0 mmHg in the change from baseline IOP (pairwise comparison of higher latanoprost concentrations vs latanoprost 50 μg/mL) at 28 days at the 5% level of significance (one-sided test). Furthermore, the corresponding power would be 58% to detect a difference of 1.5 mmHg.
Between January and March 2003, a total of 282 subjects were randomized at 25 centers (Australia, 3; Czech Republic, 5; France, 4; Greece, 1; Pakistan, 4; Portugal, 3; Thailand, 2; United Kingdom, 3) and were included in the ITT population (Figure
Figure 1
Subject disposition
Subject disposition. Flow chart of subjects detailing number of randomized subjects in each group, number of subjects withdrawing from the study, and the PP population by group.
Treatment groups were similar with respect to demographic and baseline characteristics (Table
At week 4, least square mean IOP reductions from baseline in the worse eye in the PP population occurred in all dose groups at both 8 a.m. and 4 p.m. with somewhat greater reductions at 8 a.m. (between 9 and 10 mmHg) than at 4 p.m. (between 8 and 9 mmHg; Table
The greatest mean IOP reductions in the worse eye were observed between baseline and week 1, with only slight additional reductions at weeks 2, 3, and 4 (Figure
Figure 2
Mean IOP at each time point in the study
Mean IOP at each time point in the study. Mean IOP (mmHg) during treatment at A) 8 a.m. and B) 4 p.m. for worse eye (PP population). Points indicate mean IOP (mm Hg) for each group at each time point. Error bars +/− SD. Each group is slightly offset in the graph for clarity.
Least square mean percentage IOP changes from baseline to week 4 at 8 a.m. ranged from 33.3% to 37.3% across worse and study eyes (Table
During treatment, 38% (27/71), 47% (33/70), 54% (39/72) and 45% (31/69) of subjects in the latanoprost 50, 75, 100 and 125 μg/mL groups, respectively, reported at least one treatment-emergent adverse event, the majority of which were eye disorders. Only one subject had a serious adverse event (severe endocarditis after 15 days of treatment, not considered treatment-related). Adverse events reported by ≥2% of subjects in any treatment group are shown in Table
In the overall population, 78/282 (27.7%) of subjects had conjunctival hyperemia at baseline, with most reporting no worsening of the condition from baseline to week 4. Sixty subjects (15, 17, 15, and 13 subjects in the 50, 75, 100 and 125 μg/mL dose groups, respectively) experienced a worsening of conjunctival hyperemia from baseline to week 4 while 15 subjects (3, 4, 6 and 2 in the 50, 75, 100 and 125 μg/mL groups, respectively) had an improvement from baseline at week 4. One subject in the latanoprost 50 μg/mL group had severe conjunctival hyperemia at week 4 while 2 subjects (1 each in the 100 and 125 μg/mL groups) had severe conjunctival hyperemia at weeks 1 and 2, respectively. At week 4, one subject in the 75 μg/mL group had cells/flare in the anterior chamber.
Most subjects reported no specific ocular symptoms during the treatment period. One subject in the 100 μg/mL group had a severe foreign body sensation at week 2, while three subjects (1 each in the 50, 75, and 100 μg/mL groups) reported severe itching at week 2. Two subjects (1 each in the 50 and 100 μg/mL groups) developed severe eye redness at weeks 4 and 2, respectively. Over 90% of subjects showed no change from baseline in iris pigmentation or eyelashes. Weak changes in iris pigmentation (defined as slight but clearly visible) were observed in two subjects (1 each in the 100 and 125 μg/mL groups). Changes in eyelashes were observed in 11 subjects (3, 3, 4 and 1 in the 50, 75, 100 and 125 μg/mL dose groups, respectively).
In the primary analysis, there was no statistical difference in the change from baseline in IOP at week 4 between dose groups in the worse eye (PP population) at either 8 a.m. or 4 p.m. Additional analyses also showed no significant differences between dose groups for change from baseline in IOP at weeks 1, 2, and 3 and percent change from baseline in IOP at week 4. Patients experienced a robust IOP lowering effect of 8–10 mm Hg from baseline in all groups at all timepoints. Numerically, the IOP reduction produced by higher concentrations was at all timepoints slightly less than that produced by 50ug/ml latanoprost. The robust IOP lowering effect and the power of the study lead to the conclusion that concentrations of latanoprost higher than 50ug/ml do not produce greater IOP lowering effects. These results were in agreement with the small dose-ranging study by Alm et al.
Latanoprost was well tolerated at all concentrations, with no differences between dose groups with respect any of the adverse events, including conjunctival hyperemia. There were two reports of iris darkening and 11 reports of eyelash growth, but there was no dose association for either of these events. Both are well recognized side effects of prostaglandin analog therapy
These results suggest that latanoprost is at the top of the dose–response curve for both IOP lowering and for hyperemia at the 50ug/ml dose. In order for latanoprost to produce IOP lowering, the drug must penetrate into the eye, be converted into the active latanoprost acid, and interact with the relevant prostaglandin receptors. The lack of increased effect of higher concentrations may indicate saturation of the penetration or conversion process rather than the saturation of the receptors. However, application of latanoprost more than once a day to increase the overall drug exposure does not increase IOP lowering
In addition, the observation that both IOP and hyperemia are stable over this dose range suggests that both effects are mediated by the interaction of latanoprost with same receptor. In contrast to our finding that hyperemia does not increase as the concentration of latanoprost increases over this range, dose finding studies of bimatoprost
Robust decreases from baseline in IOP were observed in all treatment groups, with no significant differences between the marketed concentrations of latanoprost (50 μg/mL) and any of the higher concentrations (75, 100, and 125 μg/ml) of latanoprost. All concentrations of latanoprost were well tolerated, with no dose association of any adverse event. Both IOP lowering and hyperemia appear to be unrelated to dose across the range tested.
Competing interests
The authors are employees of Pfizer Inc (DE, CT) or Pfizer Ltd (CS).
Authors' contributions
Individual contributions are listed below:
The study was sponsored by Pharmacia Upjohn which was acquired by Pfizer in 2003.
Editorial support, including contributing to the first draft, revising the paper based on author feedback, and styling the paper for journal submission, was provided by Linda Whetter, DVM, PhD, of Zola Associates and was funded by Pfizer Inc.
Predictive factors of the optic nerve head for development or progression of glaucomatous visual field loss
Primary open-angle glaucoma
The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration
Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial
The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
The influence of Latanoprost 0.005% on aqueous humor flow and outflow facility in glaucoma patients: a double-masked placebo-controlled clinical study
Aqueous humor dynamics in ocular hypertensive patients
Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study
Efficacy and mechanisms of intraocular pressure reduction with latanoprost and timolol in participants with ocular hypertension: a comparison of 1 and 6 weeks of treatment
Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction
Effects of prostaglandins on the aqueous humor outflow pathways
Initial clinical studies with prostaglandins and their analogues
Ocular hypotensive effect of PhXA41 in patients with ocular hypertension or primary open-angle glaucoma
Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure. A one-month study
Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning. A comparison with timolol. Scandinavian latanoprost study group
Clinical dose-regimen studies with latanoprost, a new ocular hypotensive PGF2 alpha analogue
A double masked comparison of the intraocular pressure reducing effect of latanoprost 0.005% and 0.001% administered once daily in open angle glaucoma and ocular hypertension
Latanoprost twice daily is less effective than once daily: indication of receptor subsensitivity?
The effect on intraocular pressure of latanoprost once or four times daily
A comparative study of two dose regimens of latanoprost in patients with elevated intraocular pressure
Intraocular pressure-reducing effect of PhXA41 in ocular hypertension. Comparison of dose regimens
Standardizing the measurement of intraocular pressure for clinical research. Guidelines from the eye care technology forum
Twelve-month, randomized, controlled trial of bimatoprost 0.01%, 0.0125%, and 0.03% in patients with glaucoma or ocular hypertension
Side effects associated with prostaglandin analog therapy
Prostaglandin analogues in the anterior eye: their pressure lowering action and side effects
Pre-publication history
The pre-publication history for this paper can be accessed here:


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[C++ and Ogre 3D] Castle Forge 3D
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May 23rd, 2012 (8:08 PM). Edited May 23rd, 2012 by Dying Light.
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Pegasus Knight
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Originally Posted by
That's like saying "Hey Game-Freak, why make another Pokemon game with these features if there is a rom-hack/fan-game with them?"
It's a great way to expand your coding language and to start off, and although I don't know much about game development and coding myself, it looks great. I'm even surprised you managed to replicate the game concept and design of Minecraft with GameMaker.
Well, how do you even know if Game Freak knows that some of these amazing (I mean amazing because I think our community has far surpassed and succeeded the official games) games/ROM hacks even exist? Sure, a member of the team could have viewed this site, or for all I know anyone of the PC members could be a team member of Game Freak. Now, yes, it
a great way to start off programming/coding/scripting/etc. But, at first glance, this looked like a project aiming to be an exact replica. But, as the creator stated, he originally intended this to be a sandbox style game. I applaud the creator for that. But, Game Freak hasn't even come
to the features our community has implemented. If Game Freak were to think about not creating another Pokémon game because a hack or development already had those features, they wouldn't care because it doesn't bring in money. Sure, it's a slap on the face and suggest that they make something better. Though they couldn't know if these fangames exist, they still make Pokémon games because they are for lucrative purpose. Since the fangames don't bring in money, they will continue making their own. Unlike Game Freak, the Minecraft team already has an official modding API. In this sense, they support modding, whereas Game Freak frowns upon it.
With that aside, it is amazing that the creator was able to recreate block sandbox physics into GameMaker. It is easily the best I've seen yet with the exception of third-person free-roam games on the program's website.
Lastly, for suggestions on features, I would like to see the following:
-Fully customizable character (define head/torso/pants/shoes/etc.)
-More randomly generated structures (like castles/shops/underground villages)
-Minigames (Not sure what exactly, but maybe something like defending a castle from a zombie invasion)
"Our only limits are the ones we place on ourselves."
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Furl-Of-Fresh-Leaves is an Argonian highwayman who hailed from the province of Black Marsh. He lived during the Third Era and was an accomplished illusionist. He patrolled the roads the Black Marsh with his partner-in-crime, Drawing-Flame. They attempted to rob and kill Decumus Scotti, but were interrupted by Archein Right-Foot-Rock, an Argonian trader and plantation owner.[1]
- The Elder Scrolls IV: Oblivion (Mentioned only)
- The Elder Scrolls V: Skyrim (Mentioned only)


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The magnificent architectural monuments of Novgorod earned it the name the
museum city
until World War II, when it was held by the Germans (1941–44) and suffered great damage. Chief among the losses was the 12th-century kremlin, on the left river bank, containing the Cathedral of St. Sophia (founded 1045). On the right bank, the former commercial center, were numerous medieval churches and a museum of old Russian art. Many of the damaged buildings have been restored, but their frescoes are lost.
Sections in this article:
- Introduction
- History
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I would like to give a "thumbs up" to the fifth grade girl, Emmy Chandler from Orrville, who put a letter into The Daily Record expressing how she felt when she learned Donald Trump won the presidential race.
I too was upset. I still cannot believe he won. After all the hateful remarks he said about women and how much he hated people from other countries. I guess when you have lots of money and power you can say and do whatever you want.
When you hurt men and women who went to war for our country and then make fun of them when they can't get all their words out properly. You don't make fun of their remarks when they are already broken in spirit. Making fun of women who are overweight. Who does he think he is?
I feel sorry for his wife, to probably hear for the first time about his treatment and things he did to other women. He is not God's gift to women.
Emmy -- I think you are a very smart fifth-grader. Maybe some day you will run for president. We need someone to win who really cares for other people. Someone who has compassion for everyone no matter of all their flaws and what they look like.
I don't know you Emmy, but I am really impressed by your letter and your big heart. Your parents must really be proud of you.
Barbara Forrer
MLib - first off it is none of your business about where I have been around 10 year olds. But I feel sorry for you so I had two 10 year olds and I was a Sunday School Teacher for 17 years so get over it buttercup................My daughter is exceptionally smart and at 10 she wouldn't have written a letter to the editor unless I pushed her. My son is just as smart and when I read him the letter he as well said that no 10 year old girl wrote it.
Does this make you feel better now that you know I have been around 10 year olds?
How many 10 year olds have you been around?
I am curious where you might have been around fifth graders, 3710. Are you a Sunday School teacher? Girl Scout leader? Camp counselor? Child care worker? I know for darn sure you aren't a teacher, so please share from where your experience has come.
Baggers always think everyone is as dumb af as them.
You have to be smarter than a 5th grader to be able to comprehend Emmy's letter. Obviously Darlene (3710) is not.
MLib - 2901 - I encounter a lot of 5th graders. You know darn well this girl did not take it upon herself to write this letter. I have read this letter to people who have graduated from college with a 4 year degree and they all say the same thing. A 10 year old girl did not write this letter. Now you people can live in your dream world if you want to and that is your choice.
The show are you Smarter than a Fifth Grader have questions about math, english, etc. not on how to write an appropriate letter to the editor. Now the mother is a school teacher so we can all figure out what went on here except a few of you.
Darlene, you must never have encountered many fifth graders.
Yo Darlene, Apparently you haven't seen the show "Are You Smarter Than A Fifth Grader." In your case...............
Barbara Forrer - this girl may have written the letter but wrote what mommy told her to. There isn't a ten year old out there that could write this kind of letter not to mention how many ten year olds want to write to the Editor? This is mommy's way of getting mommy's point across and it backfired.
Dang, another liberal loon.....................get over it cupcake. Hilda the beast lost. Do you need a safe room too?


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Jean Guitton (August 18, 1901 - March 21, 1999) was a French Catholic philosopher and theologian.
Born in Saint-Étienne, Loire, he studied at the Lycée du Parc in Lyon and was accepted at the École normale supérieure in Paris. His principal religious and intellectual influence was from a blind priest, Francois Pouget. He finished his philosophical studies in the early 1920s and later became a professor in many famous French universities. During World War II, he was made a war prisoner by the Nazis. In the year 1954, he earned a literary award from the Académie Française. From 1955 to 1968 he continued his works as a professor at the Sorbonne. He became a member of the Académie Française in 1961.
Invited as an observer to the ecumenical council of Vatican II, the first lay person to be granted this honor, he would become a close friend of Pope Paul VI.
He died in Paris. During his life, he was also awarded the Great Cross of the National Order of Merit, Commander of the Légion d'Honneur and of the Arts and Letters Medal.
In most of his works, Jean Guitton writes about and discusses the confrontation between human faith and human logic. During his life, he wrote more or less one hundred books.
He died in Saint-Étienne.
Académie française
|Preceded by
Léon Bérard
|Seat 10
Académie française
| Succeeded by
Florence Delay
|This biographical article about a French religious figure is a stub. You can help by expanding it.


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Colorectal cancer: Dr. Ernestine Hambrick
Monday, March 5, 1 p.m. ET
— is the second leading cause of cancer-related deaths in the United States.
When discovered early, the disease is up to 90% curable. Yet only a small
percentage of people take advantage of screening tests, often because
they are embarrassed to talk about the disease.
Dr. Ernestine Hambrick was the first woman board-certified
colon and rectal surgeon in the USA. After 25 years at Michael Reese Hospital
in Chicago, she left her practice in 1998 to create a national education
initiative, the STOP Colon/Rectal Cancer Foundation. STOP is a collaborating
partner for the annual National Colorectal Cancer Awareness Month.
Dr. Hambrick also has a very personal reason to care
passionately about stopping this cancer killer. In 1992, her older, only
brother died of colon cancer at the age of 55.
Colorectal Cancer Awareness Month Web site
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Blog » Liverpool v Spurs 2-0 | Uncensored Match Reaction Playlist
Liverpool v Spurs 2-0 | We Blew Spurs Away! | Uncensored Match Reaction
Paul was made up with the performance as Liverpool smashed Tottenham Hotspurs off the park thanks to a brace from Sadio Mane in the first half and a composed second half to send the Reds back into the top four, atleast for the weekend!
Liverpool v Spurs 2-0 | 'We're Back Above The Mancs!' | #LFC Fan Cam
This Red was made up as Liverpool went ahead of the mancs in the Premier League thanks to a fantastic team performance!
Liverpool v Spurs 2-0 | 'Mane Was Fantastic!' | #LFC Fan Cam
This Spanish Red though Mane was fantastic in a game which saw him slot two past a helpless Hugo Llloris!
Liverpool v Spurs 2-0 | 'We Made Them Look Garbage!' | #LFC Fan Cam
This Liverpool fan thought we were boss and Spurs were garbage as we destroyed Mauricio Poccetino's Tottenham side!
Liverpool v Spurs 2-0 | #LFC Fan Reactions
Paul is here with YOUR thoughts post Spurs as the Reds demolished them at Anfield!
Liverpool v Spurs 2-0 | 'Mane & Gini Both 10/10!' | Player Ratings
Chris is here with his player ratings for the team that comprehensively beat Spurs at home thanks to a great performance, mainly from Wijnaldum and Mane!
Liverpool v Spurs 2-0 | Story Of The Match Relive the match from the Kop (and the Main Stand) as the Reds beat Tottenham Hotspurs by 2 goals to nil!