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ST. LOUIS — Greg Robinson didn't want to cry, but he couldn't hold back the tears.
The Thibodaux native and former Auburn standout was introduced to St. Louis media Tuesday and recalled his draft night Thursday, when the Rams selected him with the second overall pick.
"When I got the call and hearing my family behind me, as I was on the phone, it made me a little emotional," Robinson said. "I tried to stay strong because a few guys told me don't cry, but it was just something that happened. As my mom cried, it worked on me and I shed a few tears."
Alongside Robinson during the news conference was Pittsburgh defensive tackle Aaron Donald, who worked out with Robinson in Arizona as part of the predraft process. Donald said the two never talked about winding up on the same team but added, "It's cool the way it worked out."
Robinson appeared in a commercial during the draft. In it, he discussed overcoming adversity — like the death of his father, Greg Blackledge, and living through Hurricane Katrina.
"A lot of people that went through the same things I went through, it probably took them down and they went down the wrong path," he said. "Everything that has happened in my life that's bad, I've tried to use as motivation. Responding to something bad negatively doesn't make it a better situation."
Robinson said he often thought about his dad, who never saw his son play in college. Robinson remains diligent in his efforts to be a positive influence on the Thibodaux community, where a draft watch party was held Thursday.
"I just want those people to know that there's hope and dreams can come true," said Robinson, who signed an endorsement deal with Nike and plans to make a donation to his high school. "The whole neighborhood came out to watch me get drafted. It was crazy. They blocked off the street.
"The first opportunity I could to do something positive for the neighborhood, anywhere I came from, is just a blessing and I'm happy to be in this position where I could do something like that."
Robinson, the first offensive lineman selected in the first round by Jeff Fisher in his 20 years as an NFL head coach, said he's glad the draft process is over so he can focus on football. Robinson likely will begin his career at left guard but may compete with Joe Barksdale and Rodger Saffold for the starting right tackle position.
His NFL dream becoming a reality didn't quite hit him until he walked into the team's locker room Monday and saw a large locker with his name and number above it. The 6-foot-5, 332-pound Robinson joked that he is actually able to sit in his locker — something he wasn't able to do at Auburn.
"I tried once," he said. "I was tired after practice and tried to push in the locker, but I couldn't fit."
Robinson and the rest of the rookie class — including defensive lineman Michael Sam, the first openly gay player in the league — arrived in St. Louis on Monday. They met their position coaches and teammates and will spend the next two days going through what Fisher called an orientation. The rookies will take the field Thursday for workouts and will join the veterans Monday as part of the offseason conditioning program.
Part of that rookie class is former Auburn teammate Tre Mason, a running back.
"He called me and said, 'Bro, I'm a Ram,' and I just broke out because I could hear in his voice that he was getting emotional," Robinson said. "I could hear him crying over the phone and I was like, 'Man, this is crazy. I would've never thought that.' "
Robinson and Mason committed to Auburn together and consider each other family.
"It's a dream come true to be able to play with Greg again," Mason said.
"God blessed us with that opportunity."


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Peas and Love is a food and potions store in Fable III located in Mourningwood.
Base value: 7,200 gold
Base income: 216 gold,[1].
Location: Mourningwood, Eco-Village. Second on the left when entering from Bowerstone.
Inventory Edit
- Health Potions
- Tofu
- Fruit Juice
- Carrots
References Edit
- ↑ Walsh, Doug and Epstein, Joe. (2010). Fable III Signature Series E-Guide. BradyGames. p. 263. ISBN-13: 978-0-7440-1302-3.

subset: commoncrawl


text:
Ranchi University Exam Results 2017 - MA, M.Sc, B.Tech, UG, PG Results
If you are looking for Ranchi University UG PG Result 2017 then get exam score from here. Ranchi University has conducted final examinations of various UG and PG courses in month of May/June 2017 on its official website @www.ranchiuniversity.ac.in. Candidates who have appeared in these examinations want to check Ranchi University M.Tech Results 2017. So such candidates will able to check their Ranchi University MA B.Tech Result 2017 here.The Ranchi University has published the latest results of MA, M.Sc, B.Sc., B.Tech Exam 2017.
About: Ranchi University is located in Jharkhand and it was established on 12th July 2017 as a teaching cum affiliating University. And the head quarter is at Ranchi. The University has been conducting various courses such as BA, B.Sc., MA, M.Sc., B.Sc., and many other UG and PG courses. Every year thousands of students completed their studies and pursing also. This University conduct exam as semester wise in the month of November/December and April/May. This time the Ranchi University has released the results of B.Tech, MA, M.Sc, B.Sc.
Patna University Results 2017| Check Patna University BA B.Com B.Sc Exam 2017 Results
After completion of exam students become eager to access Ranchi University MA, M.Sc., B.Sc. Exam 2017 Results.Here we have mentioned all the details and other information for the students to check Ranchi University Exam 2017 Results here by following steps below:
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Check >> Ranchi University Results 2017
Note:After declaration of results students are informed to collect the original mark sheet from the university. And those who are having an issue with their marks scored, they may apply for re-evaluation even if anyone not satisfy with their marks, they need to apply for back paper exam.
Ranchi University Results 2017:
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Epigenetic regulation of caloric restriction in aging
The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently affected by environmental factors, and caloric restriction is by far the most effective and established environmental manipulation for extending lifespan in various animal models. However, the precise mechanisms by which caloric restriction affects lifespan are still not clear. Epigenetic mechanisms have recently been recognized as major contributors to nutrition-related longevity and aging control. Two primary epigenetic codes, DNA methylation and histone modification, are believed to dynamically influence chromatin structure, resulting in expression changes of relevant genes. In this review, we assess the current advances in epigenetic regulation in response to caloric restriction and how this affects cellular senescence, aging and potential extension of a healthy lifespan in humans. Enhanced understanding of the important role of epigenetics in the control of the aging process through caloric restriction may lead to clinical advances in the prevention and therapy of human aging-associated diseases.
Aging and its direct consequences, such as degenerative diseases and even death, are inevitable; however, scientific advances in understanding basic aging mechanisms have made it much more feasible to postpone aging processes and to increase the human lifespan using clinical approaches. Current studies using model organisms indicate that aging processes can be manipulated by many interacting factors which include, but are not limited to, geneticnutritional and pharmacological interventions
Dietary control, as a major environmental factor, has a profound effect on many aspects of health, including aging, and caloric restriction (CR) is by far the most effective environmental manipulation that can extend maximum lifespan in many different species
Table 1
Summary of aging-related diseases affected by caloric restriction in experimental animal models and clinical trialsa
Nonhuman primates
CR prevents a broad range of cancer incidences, including breast and gastrointestinal cancer.
CR improves glucose homeostasis and prevents diabetes.
Cardiovascular diseases
CR lowers blood pressure and favorably alters lipid profile, resulting in significantly reducing the risk of cardiovascular disease and related complications.
Neurodegenerative diseases
CR reduces aging-associated neuronal loss and neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease.
Immune deficiencies
CR delays the onset of T-lymphocyte-dependent autoimmune diseases.
aCR, caloric restriction; Y, CR has effects on relevant physiological changes; Y/?, not resolved or not reported.
Numerous studies suggest that the effects of CR in the prevention of the onset of many aging-related degenerative diseases occur through various molecular mechanisms, including reduction of oxidative stress or regulation of metabolic pathways during the progression of aging
DNA methylation affects aging during caloric restriction
DNA methylation is one of the most important epigenetic modifications. It provides a stable and heritable component of epigenetic regulation. DNA methylation primarily occurs on cytosine residues of CpG dinucleotides, which are frequently clustered into CpG islands at the regulatory sites of gene promoter regions. The amount of DNA methylation in a gene control region generally inversely correlates with gene activation
During aging processes, there is a progressively reduced capability for homeostasis and loss of chromatin integrity, predominantly due to aberrant gene expression
Table 2
Selected genes regulated by epigenetic factors during caloric restrictiona
Gene functions in aging
Epigenetic regulation
CR effects
Tumor suppressor gene that inhibits cell cycle and accumulates during aging
DNA methylation, histone acetylation (mediated by SIRT1 and HDAC1) and histone methylation
Tumor suppressor gene that induces cell cycle arrest, apoptosis and senescence; increased
Histone acetylation (mediated by SIRT1)
Oncogene that accelerates aging
DNA methylation
Transcription factor that plays important roles in development; increases methylation with aging
DNA methylation
Up regulation
Forkhead transcription factors that control various biological functions and involve SIRT1-related longevity
Histone acetylation (mediated by SIRT1)
A component of the NHEJ pathway for DSB repair that regulates apoptosis and DNA repair during aging
Histone acetylation (mediated by SIRT1)
Regulates mitochondrial function and glucose homeostasis and interacts with SIRT1 to regulate glucose metabolism during CR
Histone acetylation (mediated by SIRT1)
Tumor promoting gene; increased
Histone acetylation (mediated by HDAC1) and histone methylation
aCR, caloric restriction;
The evidence suggests that the biological effects of CR are closely related to chromatin function
As discussed previously, two major changes in DNA methylation occur during aging progression. These changes involve globally decreased but locally increased DNA methylation status. Interestingly, CR is likely to recover these aging-induced aberrant DNA methylation patterns, but by specific loci control rather than globally
Figure 1
Caloric restriction regulates epigenetic pathways
Caloric restriction regulates epigenetic pathways. Caloric restriction (CR) influences epigenetic processes via two primary mechanisms: DNA methylation and histone modification. DNA methylation regulation during CR involves DNMT activation, resulting in silencing the expression of target genes such as
On the basis of the preceding discussion, we confirm that DNMTs play a crucial role in maintaining or rewriting DNA methylation profiles. Consistently, DNMT1 activity is significantly elevated in response to CR to correct the decreased methylation level during aging
Because of the critical roles of DNMTs in the control of aging and aging-associated diseases such as cancer and DNMT inhibitors such as azacitidine (5-azacytidine) and decitabine (5-aza-2'-deoxycytidine) have been widely used for cancer treatment in both experimental studies and clinical trials
Table 3
Epigenetic clinical trials for aging-related degenerative diseasesa
Epigenetic effect
Clinical trials
DNMT inhibitors
5-azacytidine; a chemical analogue of cytidine that affects DNA methylation as a false substrate
Phases I, II and III: myelodysplastic syndromes such as leukemia
DNMT inhibitors
5-aza-2'-deoxycytidine, a chemical analogue of cytidine that affects DNA methylation as a false substrate
Phases I, II and III: myelodysplastic syndromes such as leukemia, cervical, and non-small-cell lung cancer
HDAC inhibitors
Cyclic tetrapeptide
Phases I and II: hematological tumors such as leukemia and lymphoma
HDAC inhibitors
Aliphatic acid
Phases I and II: hematological tumors such as leukemia and lymphoma and colorectal cancer
Valproic acid
HDAC inhibitors
Aliphatic acid
Phase I: hematological tumors such as leukemia and lymphoma
Suberoylanilide hydroxamic acid
HDAC inhibitors
Hydroxamic acid
Phases I and II: hematological tumors, such as leukemia and lymphoma, solid tumors
SIRT1 activator
A natural compound enriched in grapes and red wine
Phase I and II: diabetes, obesity, Alzheimer's disease and cancers
Inhibitor of both DNMTs and HDACs
Active epigenetic diet found in soybean products
Preclinical: diabetes and cancer
Inhibitor of both DNMTs and HDACs
Active epigenetic dietary compound enriched in green tea
Phase I: diabetes, cardiovascular disease and cancer
HDAC inhibitor
Active epigenetic dietary compound enriched in broccoli sprouts
aDNMT, DNA methyltransferase; HDAC, histone deacetylase; SIRT1, Sirtuin (silent mating type information regulation 2 homolog) 1; EGCG, epigallocatechin gallate.
Since restricted caloric intake induces a series of metabolic responses to nutrition deficiency, effective regulation of metabolic processes to adapt to this change could be another important mechanism underlying the effect of CR on longevity. One approach to interpreting CR in the regulation of metabolic pathways is through interventions to treat human obesity, which has become an important public health issue in recent years. Obesity is a common metabolic disorder characterized by excessively accumulated body fat and is closely related to a series of human diseases, including diabetes, hypertension, dyslipidemia, cardiovascular complications and even cancer, which are recognized causes of accelerated aging
Surprisingly few studies have investigated genome-wide alterations in DNA methylation profiles in CR-induced longevity using
Effects of histone remodeling in control of aging during caloric restriction
Histone modifications affect the basic structure of the chromatin unit, the nucleosome. The nucleosome consists of 146 bp of DNA wrapped around an octamer of histones (two copies of H2A, H2B, H3 and H4 monomers)
Figure 2
Histone modification pathways
Histone modification pathways. Histone acetylation is mediated by HAT and deacetylation is catalyzed by the HDAC family. The upper row represents histone acetylation/deacetylation processes mediated by classic HDAC family members, including classes I, II and IV. Histone acetylation causes an open chromatin structure, leading to active transcription, whereas histone deacetylation is always associated with transcriptional repression. The middle row indicates a class III HDAC family member, SIRT1, which deacetylates both histone and protein substrates, resulting in gene silencing in most cases. The lower row represents histone methylation as another important histone modification. Histone methylation is mediated by HMT, and either gene activation or gene repression by histone methylation is dependent upon the particular lysine residue that is modified. HAT, histone acetyltransferase; HDAC, histone deacetylase; HMT, histone methyltransferase. SIRT1, Sirtuin (silent mating type information regulation 2 homolog) 1.
Histone acetylation and deacetylation
Histone acetylation and deacetylation processes are catalyzed by specific enzymes called histone acetyltransferases (HATs) and HDACs, respectively
In addition to their deacetylation function, HDACs are believed to participate in the regulation of many cellular functions and gene expression through interactions with hundreds of different transcription factors
We have found that altered binding enrichment of HDAC1, such as on the promoter regions of the
At this point, HDAC inhibitors have emerged as an exciting new class of potential anticancer agents despite little evidence pertaining to other aging-related diseases. HDAC inhibition causes acetylation of nuclear histones, leading to transcriptional activation of several key tumor-related genes, such as the cyclin-dependent kinase inhibitor
Sirtuin 1 and its substrates
Several HDAC families have been identified, including class III NAD+-dependent HDACs such as Sirtuin 1. Sirtuin 1 (SIRT1) in mammals, and its orthologs in other species (Sirtuin 2 in yeast), deserves special attention due to its fundamental impact on aging regulation and CR-related lifespan extension
The promising effect of SIRT1 in mediating CR and lifespan extension is supported by a diverse range of animal models, human subjects and even
In mammals, SIRT1-null mice do not survive longer, and most of them die during the postnatal period
In yeast, Sir2-mediated deacetylation of histones H3 and H4 and concomitant silencing of protein recruitment occurs specifically in heterochromatic regions located at extrachromosomal ribosomal DNA, telomeres and silenced mating-type loci, which benefit lifespan extension in yeast
Although classed as a HDAC, SIRT1 deacetylates a broad range of substrates, including many nonhistone substrates
SIRT1 can also regulate the expression of genes that are involved in metabolic pathways. PGC-1α represents the best example of these proteins in CR studies (Table
Another key gene that can be epigenetically regulated by SIRT1 is
Histone methylation
Besides histone acetylation, histone methylation is another important histone modification that regulates gene expression
Potential epigenetic treatments for aging-related diseases
The promising impact of the chromatin regulators on aging interference provides an excellent opportunity to prevent for human aging-related diseases by applying potential epigenetic drugs. An example of this is resveratrol, a natural compound found in grapes and red wine which has been demonstrated to extend lifespan in
Epigenetic therapy has shown powerful clinical potential in delaying aging and preventing aging-related diseases, especially cancer. As we have discussed previously, DNMT inhibitors, inlcuding azacitidine and decitabine, as well as HDAC inhibitors, such as depsipeptide, phenylbutyrate, valproic acid and suberoylanilide hydroxamic acid, have been widely used for cancer treatment in both experimental studies and clinical trials (Table
"Epigenetic diets" that mimic the effects of caloric restriction on lifespan
The significant epigenetic impact of CR on delaying aging and preventing aging-related diseases has motivated efforts to identify natural or synthetic compounds that mimic the effects of CR. A broad range of diets have been identified that mediate epigenetic processes, the so called "epigenetic diets," providing potential to reduce aging-associated disease incidence and possibly extending the quality and length of the human lifespan by simple consumption of such diets or extracted bioactive dietary compounds
Epigenetically mediated changes in gene expression have become a major molecular mechanism linking CR with its potential for improving cell function and health throughout the life course, leading to delaying the aging processes and extending longevity. Understanding the epigenetic mechanisms that influence the nature of aging by CR might lead to discoveries of new clinical strategies for controlling longevity in humans. As discussed in this review, two primary epigenetic codes, DNA methylation and histone modification, play important roles in regulating chromatin structure and expression of key genes to elicit the global response to CR (Figure
bp: base pair; CR: caloric restriction; DNMT: DNA methyltransferase; HDAC: histone deacetylase; HAT: histone acetyltransferase;
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
YL wrote the first draft of the manuscript. All other authors contributed to the development of the manuscript. All authors read and approved the final manuscript.
This work was supported by grants from the American Institute for Cancer Research (AICR), the National Cancer Institute (CA 129415 and CA 13148-31), Susan G Komen for the Cure and the American Cancer Society Award (IRG-60-001-47). YL was supported by a Postdoctoral Award (PDA) sponsored by AICR and American Cancer Society Award.
Heritability of life span in the Old Order Amish
Nutritional modulation of ageing: genomic and epigenetic approaches
Aging and cancer: can mTOR inhibitors kill two birds with one drug?
Evidence of monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (
Increased DNA methylation at the
Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?
The epigenetic basis of twin discordance in age-related diseases
Toward a theory of caloric restriction and longevity regulation
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935
Effect of caloric restriction on life span of the housefly,
Genotype of age influence the effect of caloric intake on mortality in mice
Caloric restriction delays disease onset and mortality in rhesus monkeys
How does calorie restriction work?
The effect of age and nutrition on protein synthesis by cells and tissues from mammals
The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice
A thin phenotype is protective for impaired glucose tolerance and related to low birth weight in mice
Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice
Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice
Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice
Effects of caloric restriction on cardiovascular aging in non-human primates and humans
Caloric restriction in primates and relevance to humans
Caloric restriction in humans
Oxidative stress, caloric restriction, and aging
Molecular mechanisms linking calorie restriction and longevity
Chromatin modifications and their function
Dietary effect on epigenetics during the aging process
Epigenetics in human disease and prospects for epigenetic therapy
Effects of caloric restriction in animals on cellular function, oncogene expression, and DNA methylation in vitro
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of
Requirement of NAD and
Calorie restriction: the
Sirt1: a metabolic master switch that modulates lifespan
SIRT1 transgenic mice show phenotypes resembling calorie restriction
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
DNA methylation and gene function
CpG islands and genes
The emerging science of epigenomics
Role for DNA methylation in genomic imprinting
DNA methylation, genomic imprinting, and mammalian development
Relationship between transcription and DNA methylation
Eukaryotic cytosine methyltransferases
The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin
DNA methyltransferases
Assignment of cytosine-5 DNA methyltransferases
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
Pathophysiology of ageing
Accelerated age-related CpG island methylation in ulcerative colitis
Methylation of the oesterogen receptor CpG island links ageing and neoplasia in human colon
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis
DNA methylation in aging of mice
Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples
Genomic 5-methyldeoxycytidine decreases with age
Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma
Calorie restriction and the exercise of chromatin
Epigenetic control of aging
Caloric restriction attenuates age-related changes in DNA methyltransferases 3a in mouse hippocampus
DNA Methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs
Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies
Impact on DNA methylation in cancer prevention and therapy by bioactive dietary compounds
Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells
Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms
Connecting obesity, aging and diabetes
The Diet, Obesity and Genes (Diogenes) Dietary Study in eight European countries: a comprehensive design for long-term intervention
A dual epigenetic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss
Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction
TNF-α promoter methylation as a predictive biomarker for weight-loss response
Crystal structure of the nucleosome core particle at 2.8 Å resolution
Enhanced histone acetylation and transcription: a dynamic perspective
Histone deacetylases (HDACs): characterization of the classical HDAC family
The language of covalent histone modifications
Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines
hTERT is a critical determinant of telomerase activity in renal-cell carcinoma
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects
Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment
Histone deacetylase inhibitors: current status and overview of recent clinical trials
Sulforaphane causes epigenetic repression of
Regulation of SIRT1 protein levels by nutrient availability
Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction
Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
Mammalian sirtuins: emerging roles in physiology, aging, and calorie restriction
The mammalian SIR2α protein has a role in embryogenesis and gametogenesis
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
Negative control of p53 by Sir2α promotes cell survival under stress
Human sir2 deacetylases p53 and antagonizes PML/p53-induced cellular senescence
Stress-dependent regulation of FOXO transcription factors by the sirt1 deacetylase
Mammalian sirt1 represses forkhead transcription factors
Gluconeogenesis: re-evaluating the FOXO1-PGC-1α connection
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of lifespan in
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs
Sirt1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
Sirt1 regulates the histone methyl-transferases SUV39H1 during heterochromatin formation
Sirt1 promotes DNA repair activity and deacetylation of Ku70
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
Differential CDK-inhibitor gene expression in aging human diploid fibroblasts
Regulation of the
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
Histone and chromatin cross-talk
Histone methylation in transcriptional control
The polycomb group proteins bind throughout the
The oncogene and polycomb-group gene
SW1/SNF mediates polycomb eviction and epigenetic reprogramming of the
Small molecule activators of sirtuins extend
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Effects of resveratrol on lifespan in
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
Resveratrol and life extension
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
Resveratrol improves health and survival of mice on a high-calorie diet
Clinical trials of resveratrol
Resveratrol: challenges in translation to the clinic: a critical discussion
Epigenetic therapy of cancer: past, present and future
Epigenetic targets of bioactive dietary components for cancer prevention and therapy
The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies
Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes
Tea, obesity, and diabetes
Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia
Identification of potential caloric restriction mimetics by microarray profiling
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Barker -- Schjenken
Crystal Barker and Joshua Schjenken were united in marriage June 11 in Sacred Heart.
The bride is the daughter of Stan Barker of Glenwood and Pamala Barker of Spicer. The groom is the son of Bob and Tammy Schjenken of Sacred Heart.
Matron of honor was Stephanie Schjenken, sister of the bride. Bride's attendants were Brianna Holmgren, Christy Vejtruba and Tara Iverson, friends of the bride; Michelle Johnson, sister of the bride; Taryn Berg, cousin of the bride; and Audrey Frey, sister of the groom. Flower girls were Emma Holmgren, goddaughter of the bride, and Courtney Schjenken, daughter of the couple.
Best man was David Schjenken, cousin of the groom. Groom's attendants were Jon Driggs, Dan Driggs, Brian Santjer and Matt Thein, friends of the groom; Ryan Schjenken, cousin of the groom; and Beau Barker, brother of the bride. Ring bearer was Connor Frey, godson of the groom.
Ushers were Aaron Barker, brother of the bride; Aaron Wulf and Jerry Mertens, friends of the groom; and Jason Frey, brother-in-law of the groom.
A reception and dance were held at the American Legion in Spicer.
Following a wedding trip to Walker, the couple lives in Sacred Heart. The groom is employed by Renville County in highway maintenance, and the bride is a nursing student at Ridgewater College.


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I just got a head's up from Mark Dingbaum at Change.org announcing the news. It seems that the VA Hospital in Dallas is doing the right thing. Nurse Nanci Pandathurai has been suspended from seeing patients. To be clear, she is still going to work while the investigation concludes. Her duties will now be more [Read More…]
Nurse suspended after 'Lifestyle of sin' for gays with PTSD
November 18, 2011 by 6 Comments
Support for gay veteran with PTSD who had 'lifestyle of sin' diagnosis
November 11, 2011 by 4 Comments
I'd just like to say thank you to all the people who signed the petition in support of Esther Garatie. In just two days, it went from 6,000 signatures to around 12,000 signatures – each one generating real email traffic to government officials. Quick recap Esther Garatie went to the Dallas VA Hospital with severe [Read More…]


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Is there a way to make this a momentary latch instead of latching?
Hi Dave, see the picture and wiki , there is a jumper ."A. Latch – Connect pin 1.2
B. Interlock – Connect pin 2.3
C. Non-latch – Empty"
Hi, can I use it with"315Mhz remote relay switch kits - 2 channels"
Yes, you can.
Lets say I set the 'lock' and 'unlock' key on the keyfob to this relay. If I switch ON this relay using lock key code, can the relay be switched OFF using the unlock key code?
Also, do you sell the 433mhz RF module that can replace the 315MHz build
Yes, the keyfob is work as what you said with this module. For the 433mhz RF moudle, here is the link( http://www.seeedstudio.com/dep... , but we are not sure if i
I have seen what looks to be the same device advertised elsewhere as 315 and 433mhz. Is this device ONLY 315mhz? Or will it adapt to 433mhz transmitters as well?
Dear customer, for this module only support 315mhz. But you can see there is a board vertically inserted on it, that is 315mhz RF module which you can change to 433mhz. So it should solder by yourself and need another 433mhz RF module.
Can I use this http://www.seeedstudio.com/dep...
to control this one? Any doc?
Hi there, http://www.seeedstudio.com/wik... our WIKi has a zip file call Virtual Wire.
That demo code can let you send signal to this relay. But don't too short , at les
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text: What does it take for kids to be ready for school? Melanie 13 décembre 2016 Why kids who have trouble behaving in preschool fall behind Janelle J. Montroy, The University of Texas Medical Branch et Ryan Bowles, Michigan State University Children who aren't ready for school tend to lag behind their peers in later grades. Parents and teachers can help.


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Impax Laboratories, Inc. (NASDAQ:IPXL)
Credit Suisse 2012 Healthcare Conference Call
November 14, 2012 1:00 pm ET
Carole S. Ben-Maimon – President-Global Pharmaceuticals
Michael J. Nestor – President-Impax Pharmaceuticals
Unidentified Analyst
Good afternoon. We'll get started with our next presentation. We are very pleased to have with us Impax this afternoon and we are fortunate enough to have heads of multiple parts of the business. We have Carole Ben-Maimon, the Head of the Generics side and Michael Nestor, who runs the branded business. Also with us for Q&A is Bryan Reasons, the Chief Financial Officer.
With that, I'll hand it off to Carole, and we'll get started.
Carole S. Ben-Maimon
Good afternoon, everybody. Can you hear me? Yeah. And thanks for coming and, unfortunately we don't have a full house, but we are happy that those of you who are here are here and we're hopeful to give some interesting information. So I'm going to start by talking a little bit about Impax and then I'll spend some time talking about the Generics business and then I'll turn over to Michael Nestor, who runs our brand business.
Before I begin, our discussion today may include certain forward-looking statements, and actual results may differ from those presented here. The factors that could cause such differences are outlined in our SEC filings and on our website.
Our core competency is our drug delivery technology and encompass formulation expertise. The focus on technology is really what drives our business and our growth at Impax. From these core competencies we have built two businesses, a Generics business where we are targeting high value ANDAs and the brand business, where we can create formulations that lead to improve medical treatment for being for patients with meaningful problems.
In our generic business, our strategy it's a target end dose that are difficult to develop, which can provide a competitive advantage and bring sustainable profitability to our business. This includes products with the potential for six months exclusivity being first to file or products that have complex formulations and therefore maybe less competitive. We are also focused on expanding through our generic portfolio through partnerships and in licensing or in co-development of alternative dosage form.
Our current pipeline of 45 pending ANDAs at the FDA for a waiting approval as well as 24 products are underdevelopment and are designed to drive our future growth. The brand business is currently focused on the CNS space, where we can deliver important patient benefits and develop strong intellectual property. We believe the successful development of our brand business it's critical to our future growth as brand products provide longer product life cycles with the potential to have significantly higher margins.
We continue to make strides in achieving our long-term objectives as we are quickly approaching right carries PDUFA date and have an ongoing Phase IIb study in IPX159. The significant investments we continue to make in R&D remain a driving force in growing our business. Previous internal investments have created significant financial flexibility as we ended up the third quarter of 2012 with a strong balance sheet and $340 million in cash and short-term investments and we have no debt. But this provides significant financial leverage, which can be used to strengthen our business, expand our business as we invest in our business. We've been very active pursuing business development candidate and an external partnership that are consistent with our stated objectives of high growth, high margin opportunities. Our approach continues to be very diligent as we are searching for assets that are strategically right and financially attractive.
Our Generics business continues to invest in research and development to deliver high-value Adderall that are productive and still our need. We continue to file new Adderalls from both internal development and in licensing co-development efforts. In addition to this effort, we are aggressively looking at opportunities to acquire products, technologies or companies with strategic value. One objective is to expand our business into other dosage form such as injectable, creams and ointments, inhalers or patches.
In June, we announced an agreement with TOLMAR to commercialize up to nine currently approved generic topical prescription drug product. We initiated commercialization on three of these in October and the remaining will be commercialized throughout November. This represented a first opportunity to commercialize alternatives such form from a long side our current solid oral dosage business.
In addition, the agreement included two generic topical products pending at FDA, one of which is a generic form of Solaraze gel and is the first-to-file opportunity. We are also exploring opportunities outside the U.S. to allow us to move into international markets.
In our Generics division, future opportunities, most are currently marketed on portfolio of 48 ANDAs. Our pipeline remains strong with 45 products pending at FDA and 24 more products under development. These 69 products in the pipeline currently have U.S. brand sales approximating $25 billion. This is a clear indication of the potential value we have in our pipeline.
Currently, the outstanding warning letter at Hayward inhibits our ability to obtain approval for a number of our internally developed ANDAs. We expect that upon the resolution of the warning letter, we should begin to see approvals for new products and we look forward to commercializing these opportunities.
We continue to execute our strategy of diversifying our product base by growing our partnership relationship with products in alternative dosage areas. In just over two years we have partnered with four different companies and on numerous alternative dosage products.
In the short time we now have a partnership portfolio consisting of nine approved generic products, six products pending at FDA and nine products in the development stage. These 15 products have brand and generic sales of approximately $3 billion, with a number of them being first-to-file or first-to-market opportunities. Even more important is that many of these alternative dosage form products are expected to have good market sustainability, and therefore, provide long-term growth for our business.
With the recent additional competition on fenofibrate capsules and generic Adderall XR it's expected to impact our base business. We currently expect to remain competitive and continue to pursue these markets aggressively.
Our ANDA internal and external portfolio of 45 products pending at FDA contains a number of state certain launches, in addition to numerous and undisclosed product opportunities. As is typically the case, eventual product launch will depend on receiving FDA approval and the market dynamics at the time of the approval.
One product already approved is our formulation of the original Opana ER. Prior our settlement agreement, we can begin marketing that product on January 1, 2013 till next year. Because we were first to file, we expect to have six months exclusivity. However, marketing of the original Opana ER is hard to predict at this time and depends on a number of factors that we are closely monitoring.
In addition, we expect to see a boost to our cash levels with the first quarter of 2013 we have a payment of $110 million from Endo under our settlement agreement. Some of the potential launch opportunities over the next three years that we have focused, that we have disclosed and are focusing on include Opana ER in January 2013, CONCERTA in July 2013, TRILIPIX in January2014, RENVELA in March 2014, which is the first to file opportunity and should have six months of exclusivity and Velcro in January 2015 where we have settled for three months of exclusivity.
Between our internally developed ANDAs and the addition of numerous alternative dosage, dosage borne products through partnership. We have a pipeline of opportunities in the years ahead.
I will now turn this over to Michael Nestor and he'll talk to you a little bit about the brand business.
Michael J. Nestor
Thanks Carloe. Good afternoon everyone. Our brand business is focused on improving health and extending lives through advancing knowledge of treatments to neurological disorder. We believe the successful development of our brand business is critical to our future growth as brand products provide longer product lifecycles with the potential for significantly higher profits.
Our brand business growth strategy is similar to that of our generic business in that we will continue to focus our efforts on our internal research and development program while searching for additional external growth opportunity. Now in the center of this chart, our internal initiatives near-term, our team is focused on NDA approval, pre-launch preparation and launch planning of Rytary and to bring IPX159 through development.
Our neurology focused sales force is promoting and sampling Zomig here in the U.S. But earlier this year, we were pleased to obtain a licensing agreement for Zomig consistent with our goal to increase the revenue and financial contribution of our brand business to Impax. The transaction was immediately aggregative and we expect Zomig will contribute meaningfully to our total company revenues and earnings this year and next.
To complement our internal drivers we have a set of external initiatives as well. These include the acquisition of marketed products, the acquisition of companies, the in-licensing of products and collaborations in pipeline development and commercialization.
Rytary is our extended release capsule formulation of carbidopa-levodopa intended to maintain consistent plasma concentration of levodopa for a longer duration. Rytary has undergone extensive clinical development including multiple studies in both early and advanced Parkinson's disease patients both in the U.S. and Europe. The NDA included data from three controlled Phase III studies and two open label extensions in both early and advanced Parkinson's disease. Rytary has been investigated in more than a 1,000 subjects.
In October, we announced that the FDA extended the Rytary PDUFA date by three months in order to review our September submission of requested information. The new PDUFA date is now January 21 of 2013, no new clinical trials or studies have been requested by the FDA to-date. This delay is not related to the warning letter in Hayward and while we are disappointed in the delay, we continue to have dialog with the agency and remain excited about this product and its market potential.
Now Rytary was filed as a 505(b)(2) application with the FDA, which entitles us for three years of exclusivity. Now in addition, we have one formulation patent that expires in May 2022 and other patents pending, which will expire in December of 2028.
We continue to make progress in our pre-launch planning for Rytary, as we prepare for our first quarter 2013 launch. Throughout this year we've been analyzing product positioning and managed care research with more than 1 million U.S. Parkinson's patients. We believe there is a significant commercial opportunity for Rytary. We've also been analyzing product forecasts, preparing our marketing approach and programs as well as our sampling program, all in anticipation of a successful launch upon approval.
Now, our next CNS brand project is IPX159 for Restless Legs Syndrome, a significant neurological disorder with few treatment options. IPX159 is an ex-U.S. molecule that has not been approved in the United States and is approved in other regions for a different indication. This compound has an established pharmacologic profile that has been an asset in our development efforts to-date. As an ex-U.S. compound, IPX159 maybe filed as a new chemical entity in the U.S. and is expected to be eligible for five years of regulatory exclusivity. We have not disclosed the compound as we continue to develop our intellectual property position around this asset.
The ILS market, we think is a large and unsatisfied market, with approximately 25 million Americans experiencing RLS symptoms in the U.S. and an estimated market size, about $800 million. Physicians have few treatment options available to them with dopamine agonists being the dominant therapy. There is, we believe, significant need for alternatives to existing therapies to give physicians and their patient's additional options for treatment.
In December of 2011, we advanced IPX159 to a Phase IIb study, which will help establish its clinical profile in moderate to severe RLS patients. We are looking forward to completing the Phase IIb clinical trial by the end of this year and we expect to be able to report top line results no later than first quarter next year.
Now, before closing, what I would like to do is update you on the progress in the expansion of our Taiwan facility. This facility would be the primary manufacturing site for Rytary as well as many of our immediate release generic products, which are being transferred from our Hayward facility.
In July, the FDA completed the pre-approval inspection of Rytary and an undisclosed generic drug at our Taiwan facility and there were no Form 483 observation. The company has committed significant resources to improving the operation of all of our production facility and to strengthening our company-wide quality systems.
The expansion project with Taiwan is expected to be completed in mid-2013. As we ramp up manufacturing within this facility, we expect to begin to achieve some additional manufacturing cost benefits.
In closing, we have a strong platform for growth and the right strategy without dual strategic focus. We continue to make significant progress towards our long-term goals. The objectives that we set for the company will position us well to continue to face competition effectively in the future and is intended to provide the basis or above average returns for our investors.
With the current cash that we have on hand and absence of debt we have a significant resources to continue to invest in our business, which we plan to do both internally with the expansion and improvement of our facilities and externally through partnerships or even selected strategic M&A opportunity. We've remain diligent by making smart investments with accretive returns such as the Zomig and TOLMAR transactions and while we look externally for development opportunities, our internal research and development remains the driving force for our future growth. Thank you.
Unidentified Analyst
Thanks Michael and Carole. We have a minute or two for questions before we move to the breakout room, if anybody would like to ask a question please raise your hand and we'll get a microphone over to you.
Maybe I'll start one of just kind of picking up on Michael's presentation on Rytary. Could you talk a little bit about how you view the commercial opportunity for this drought? How large in opportunity do you think it could be and what are some of the key attribute to the product that you think will how do you reach that opportunity?
Michael J. Nestor
So as we've looked at this marketplace, we believe that the market potential for Rytary within the United States is somewhere between $200 million and $400 million in peak sales. From the standpoint of attributes of the products that we think will certainly resonate with patients and hopefully with physicians as well. Are those of the results that we saw with the Phase III clinical trials that is a highly statistically significant increase in the amount of on-time that patients will be able to experience relative to immediate release carbidopa-levodopa that is prescribed in this category as well as carbidopa-levodopa, entacapone. I think the fact that patients will have this degree of control without having to take their medication if you will 6, 7, 8 times a day. So patients will be more consistently maintained on a therapeutic level for a longer period of time to give a more consistent response. And we believe ultimately that that will lead to a much better quality of life to Parkinson's disease patients.
Unidentified Analyst
Okay. Any questions from the audience?
Question-and-Answer Session
Unidentified Analyst
What's the difference between the 200 and the 400 in your calculation?
Michael J. Nestor
I think part of it depends on pricing, part of it depends on we've looked at different ramp rates for the product. So those would be the key variables there, do you have any update on the Hayward facility?
Michael J. Nestor
Update on Hayward.
Carole S. Ben-Maimon
Yeah. So, as we've told you, we will, as soon as we know anything that's material we'll let you know. We've told you that we've completed most of what we've been asked to do. We are still pursuing all the opportunities to improve that we possibly can and looking to continue to get ready for that introduction and FDA will come when FDA comes. So, but soon as we have something that's material and we know what the outcome will be we will let you know.
Unidentified Analyst
Unidentified Analyst
Correct me if I'm wrong on this, but is the Hayward facility also listed on the application for Rytary, and if so, will that cause any kind of delay as that paper works were to get, it's primarily going to be manufactured in Taiwan. How does that work as far as getting all that cleaned up if Hayward is not approved?
Michael J. Nestor
Hayward is listed as an alternate manufacturing site on the NDA for Rytary. And our view relative to that is as we get closer to the PDUFA date, if we have not had the FDA re-inspect, Hayward will evaluate withdrawing the Hayward site as a alternate manufacturing site from the NDA. The process is pretty straightforward in that regard. The key thing for us, however, is the fact that we had the pre-approval inspection in Taiwan where Rytary will be that if you were the center of manufacture and there were no 483 observations relative to that pre-approval inspection. Yeah, I think we will wrap up there and head to the breakout room we'll be in the Canyon room.
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VIDEO: Luis Suarez Bit My Finger
BREAKING: FIFA has suspended Luis Suárez for nine games and four months overall, including club matches. pic.twitter.com/9MASLNwssH
— SportsCenter (@SportsCenter) June 26, 2014
Here's some of my favorite Suarez memes:
After Luis Suarez is banned from futbol for biting, Walt hires him to be his chomping bodyguard. #BetterCallSaul pic.twitter.com/Yo1ulOMewN
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text:
Reflections of a New Parent of Two, Part 2
The next in the series of initial observations I've made in my five weeks since becoming a parent of two under two:
3. Toddlers are fascinated with babies. Except maybe your own toddler.
You can barely keep others' delighted little hands from your baby's face, while your own kid will barely sit for a picture with him.
I can understand, though. From his viewpoint, this little loaf-of-bread-sized human has invaded your world and is taking up some of Mom and Dad's time and attention–Not to mention it's no fun; it only sits there staring and making noise. It doesn't even have WHEELS, for crying out loud. It makes sense that you might not be super excited about this whole 'baby brother' business right away.
Discouraging as it may seem at first, however, things do improve. Why, not long ago, Sonny yelled, "BABY!" and biffed Little Bro's sock monkey at to him… with more enthusiasm than we wanted, but it's a start.
Over the past month, I've seen Sonny warm up to his little brother, pointing out his feet or stalling bedtime by asking to say goodnight to him. He'll come over and pat him on the head while we encourage him. It's a wonderful thing… I think.
I'm confident they'll be great buds one day. In the meantime, I'll probably just keep an eye on things, lest my baby boy mysteriously somehow end up curbside in the recycling bin.
To be continued…
Category: Babies & Toddlers, Family, Mom who Blogs
About the Author (Author Profile)I am a lifelong (award-winning!) cartoonist and mother of two delightful boys, aged 4 and 2. I like to view today's adventures in parenting as material for tomorrow's cartoon. Looking at family life through "cartoon-coloured glasses" helps me keep the all-important sense of humour required for raising kids... even for the events that don't seem so funny at the time. Author's website.
Comments (7)
Trackback URL | Comments RSS Feed
Good sibling relationships are wonderful! I think it is easier to do with some kids than others. When personalities are vastly different (or too alike as well!) there can be a lot of head butting (literally and figuratively). I am so happy my tow kids love each other so deeply and are best buds.
My older children were not too impressed either when my younget was born! But as he became older and not just a baby that liked to cry then they realized that yes! they do love him! It took a bit of getting used to for them but now they play wonderful together.
My boys have been through this, being 18 months apart. I'll say this, my younger son is really tough. He's had to be!
Awe they will be great together
I have lots of good memories with my own brother and sister,the fights the fun,the laugh….it makes for great conversation now that we are adults


text:
Team Services | TFS 2017 | TFS 2015 | TFS 2013
Gain insight into the progress you're making and the quality of your software development projects. You can collect status and trend charts into dashboards that you share with your team and stakeholders.
For more complex reporting requirements, you can open or customize a dashboard or report. Your choices depend on whether you're working in the cloud or on-premises, and resources configured for your on-premises TFS.
If you're new to working in Team Services or TFS, see Get started with Agile tools to monitor progress and trends tools.
Feature availability: The following charts, dashboards, reports and tasks are available from Team Services (cloud service) or from the web portal of the listed on-premises TFS version or a later version. Those not annotated are available from all platforms and versions. Visit the Visual Studio Downloads page to get the latest TFS update. Additional resources may be required as annotated.
Lightweight work tracking charts 1
DevOps charts and widgets
- Build history (TFS 2015.1)
- Release summary (TFS 2017.1)
- Requirements quality (TFS 2017)
- Test status, progress, and result charts
- Test quality trend chart (TFS 2015)
Dashboards (Web portal)
- Create and manage team dashboards (TFS 2015.1)
- Add charts and widgets to a dashboard (TFS 2015)
- Pin an item to a team dashboard (TFS 2015)
- Add markdown guidance to a dashboard (TFS 2015.1)
- Widget catalog (TFS 2015.1)
Excel and SQL Server Reports
(TFS only)
Dashboards (Project portal) 5
(TFS only)
- These charts are built from the real-time, work tracking data store.
- These reports are built from the SQL Server data warehouse and cube and require that your team project is configured with SQL Server Analysis Services.
- These reports are built from the SQL Server data warehouse and cube and require that your team project is configured with SQL Server Analysis Services and SharePoint Products.
- These reports are built from the SQL Server data warehouse and cube and require that your team project is configured with SQL Server Analysis Services and SQL Server Reporting Services.
- Project portal dashboards available to you depend on the version of SharePoint Products configured to integrate with TFS.
The quickest way to view progress is to create work item or test result charts. These charts are always up-to-date because they get data directly from the TFS data stores.
Status or trend charts
You can create several types of charts -- such as pie, column, or trend -- for the same flat-list query.
Test results and test status charts
Visualize the test status for a specific test suite or progress made in testing a user story.
You can also see how many tests each tester has left to run.
Dashboards (Web portal)
Teams can create multiple dashboards to share information, access quick links and other functions, and view status, progress, and trends. Easily add and rearrange widgets on the dashboard to show recent changes made to source control folders, build status, and charts created from work item queries.
Excel Reports (TFS)
You can track your team project's burn rate, bug backlog, software quality, test progress, and other metrics by viewing a default Excel report.
Here are examples of two of the Excel reports.
Default Excel reports require that your team project is configured with SharePoint Products and SQL Server Analysis Services. If these reports aren't available to you, you can create ad-hoc reports in Excel from a work item query or by connecting to the Analysis Services cube.
Adhoc status and trend reports
|Bug tracking
|Test tracking
SQL Server Reporting Services Reports (TFS)
Default SQL Server reports reports differ based on the process used to create your team project. Also, several of these reports gather data points into a single report. For example, the Stories Overview (Agile) report presents a snapshot of the work that has been performed for the filtered set of user stories to the current date.
Each process—Agile, Scrum, CMMI—provides several default Reporting Services reports. These reports require that your on-premises TFS was configured with SQL Server Analysis Services and Reporting Services Reports.
If you didn't add these services previously and want to add them now, see Add reports to a team project.
|Build and code quality
|Progress (Scrum-specific)
|Progress (Agile and CMMI)
|Bug and test tracking
To manage the data warehouse or troubleshoot problems that occur, you use the Warehouse Control Web Service. See Manage TFS reports, data warehouse, and analysis services cube
Project portal (SharePoint) dashboards (TFS only)
SharePoint dashboards collect a number of Excel reports and team project data within a single view hosted on the project portal. For example, the Quality dashboard provides an overview of progress occurring in the test, development, and build areas as they relate to the quality of the software under development.
Dashboards available to you depend on the version of SharePoint Products configured to integrate with TFS.
Different dashboards are available to you based on the process you selected to create your team project.
Agile and CMMI
Related notes
If you're new to working in Team Services or TFS, see Get started with Agile tools to monitor progress and trends tools.
Other useful resources include:
- Choose a process provides an overview of the three default processes used to create and update team projects
- Support rollup of work and other fields provides information on how to generate rollup data when working with parent-child linked work items
- Components of the TFS data warehouse provides more information on the structure and relationship of the warehouse and reports
- Feature index for Team Services and TFS
Add custom fields
You can add data to support reporting requirements in the following ways:
Add a custom field (Inheritance process model, Team Services) or Add or modify a field (Hosted XML or On-premises XML)
Add work item fields to the data store, relational database, or data warehouse. See Add or modify work item fields to support reporting (TFS).
Incorporate data from other resources to an Excel report using PowerPivot. PowerPivot for Excel 2010 is a data analysis add-in for Microsoft Excel 2010. By using this add-in, you can generate reports that combine data from other data stores or databases with data from Team Foundation Server. For more information, see Microsoft PowerPivot.
Create an adapter to add new data types to the data warehouse (TFS). An adapter is a managed assembly that implements IWarehouseAdapter. An adapter uses the warehouse object model to interact with the TFS data warehouse. When an adapter adds data fields to the warehouse, it programmatically extends the schema that defines data that is moved to the warehouse. For more information, see Data Warehouse Extensibility and How to: Create an Adapter.


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How To Silence The Side Of Yourself That Wants To See You Fail
Ever feel like you're waging an internal war? It might not be bloody, but it does kill. It kills your self-esteem, confidence, and your dream.
One side wants to see you succeed, feel good about yourself, and exceed in all of your endeavors. The other is taking every chance it gets to drag you down. The fierce battle between the two sides can drive anyone crazy.
Becoming an entrepreneur means taking major steps outside your comfort zone. It will most likely trigger fear, disbelief, and doubt. It will probably make that mean voice inside seem louder and even more condescending.
If that's the voice that's running your inner dialogue today, it's time to make it stop. It's time to say goodbye once and for all.
Here are the 5 steps on how to silence the side of yourself that wants to see you fail:
1. Detach yourself from your toxic thoughts
The monkey. That's what I call that destructive and mean voice that can come in and overpower us. Because let's face it, it can behave just like a drunk, neurotic monkey who's tirelessly jumping around and chattering in a desperate attempt to get our attention.
The monkey thinks he's protecting you. But in reality, he's hindering you from creating the life you truly desire. Why? Because the monkey is trying to protect what you've accepted as truth — whether it serves you or not.
If you believe that making money requires hard work and struggle, the monkey will want to prove you're right. If you think you aren't smart enough or consistently lack time, the monkey will do just about anything to prove that your belief is correct.
The thing is, if you've heard something repeatedly in the past, or if you've had an emotionally painful experience, your monkey will remember that. And he'll do just about anything to protect you from feeling that pain again.
Now, it might sound like this little guy is your enemy. He's not. He's just a scared little monkey who needs you to take charge of the situation.
So, when you have these toxic thoughts, start by separating the monkey's voice from your own. It's not you talking, OK? Detach yourself by acknowledging and observing his presence. Don't fight or get upset over his comments; that will only fuel him. Instead, be polite, and greet the little fellow by saying, "Well, hello little monkey!"
"Once you replace negative thoughts with positive ones, you'll start having positive results." – Willie Nelson
2. Take control over the chatter
So, now that you've acknowledged the monkey, it's time to calm him down. How do you calm a drunk and neurotic monkey?
That's right, by giving him a big hug. And by telling him soothing phrases such as, "Thanks for looking out for me, but don't worry. I've got this under control." You can even imagine yourself petting the little monkey on its head.
Remember that poking current beliefs is scary to the monkey. It will trigger him. To remain in control of your inner-dialogue, simply acknowledge what caused your monkey to go bananas. Play detective on yourself to get the bigger picture of the situation.
Maybe you're stepping outside of familiar boundaries? Maybe you're facing struggles on your path as an entrepreneur? Maybe you're diving headfirst into something that scares you silly?
Remember, it's probably a good thing you're doing here. You're probably stretching limits, breaking boundaries, and growing as a person. See the situation for what it is (and not through the eyes of a terrified and neurotic monkey).
So, sooth your monkey, and simply acknowledge what made him scared. That's how you put yourself in the driving seat. That's how you become the master of your monkey (and not the other way around).
3. Replace negative thoughts with better feeling ones
Now that you've calmed the monkey, look for better-feeling thoughts around the subject. The trick here is to find thoughts that are positive, but not too positive so that your mind asks, "What the heck are you talking about? This isn't what you've been telling me!"
Thoughts gain momentum, so you can't instantly go from "I can't do this" to "I can totally do this!" without feeling like a big liar. So go step-by-step. First aim to reach a neutral place. Play around with thoughts until you find those you resonate with emotionally. Here are some of my favorites:
- "I've done similar things in the past, and that's gone well."
- "It doesn't matter where I am today, when I know where I'm going."
When you've managed to come to a neutral place, find more positive thoughts that can lift you toward a positive place. Once you've done that, reach for another one that makes you feel a little bit better than the previous one. Small and simple steps, that's all.
4. Keep nurturing your positive thoughts
So, now that you've shifted focus to more positive thoughts, things start to become clearer. Ah, the haze is dissolving (love those moments!), and you can start building positive momentum that will propel you forward.
Now, think of your thoughts as a garden. Whatever you plant there will grow. The monkey loves a beautiful and prosperous garden where he can relax. If that's what you're growing, he doesn't need to worry for you. Then he can just sit back and smell the flowers.
So, pay attention to what you're planting in your garden. Are you growing appreciation or criticism? Is it a garden full of opportunities or limitations? Is it the successes or failures in your life that are in bloom? The flowers you take most care of will blossom and overshadow the others.
Simply, bask yourself in the feelings of already being, doing, and having what you want.
"You cannot have a positive life and a negative mind." – Joyce Meyer
5. Leave room for the voice that will guide you right
Being bullied around by your inner voice is hard. Not only does it shatter your great vision – it leaves you feeling unworthy, disempowered, and frustrated.
You deserve to feel good about yourself. You deserve to live a life of excitement, exhilaration, and bliss. You deserve to make your dream a reality. That's the whole purpose of a dream, isn't it?
So, take control. Calm and soothe your monkey when he's active, and nurture your positive thoughts. Don't let your monkey master your life. Instead, master your monkey to master your life.
Leave space for that voice inside that wants to see you succeed and be happy. That's the voice worth listening to. That's the voice that knows what you're truly capable of. That's the voice that will guide you right.
What do you do to silence the side of yourself that wants to see you fail? Leave your thoughts in the comment section below!
Great article, Maria!
I couldn't agree more that becoming an entrepreneur requires you to go way beyond your comfort zone. It might be temporarily uncomfortable but the payoff is amazing 🙂
Thanks Camilla!
Yes, you are so right. Well said. Got to keep our eyes on the prize 🙂
My inner voice is Cissy. She's afraid of everything. We're going to have some good conversations from now on.
Oh, awesome!! Love your attitude 🙂
Love your advice about talking to the monkey! "Thanks for looking out for me, but don't worry. I've got this under control." I'm going to try it today.
Thank you Nicki! Have a great last day of 2015!
Great article maria. I am really impressed with your writing skills.
Thanks a lot! You just put a BIG smile on my face.
Have a great day!
This so totally sums up that split of voices in my head that argue so often! Thank you for these great strategies.
You're so right Laura. Thank you for your comment and have a great day! 🙂
Hi Maria,
You're post is spot on, our thoughts can make or break us…the posts has great points on how to make it work.
Thank you for your comment Ann!
Maria thank you for sharing this advice. While I have been able to get the monkey off my back in recent times, I still find the chatter can be an issue. I will definitely use tip number two to try and settle this down in times of need. Thank you again for taking the time to write this piece.
Hi Tim,
Thanks for your comment and kind words!
I'm happy to hear that, I hope it calms your monkey 😉
Ha-ha, love the monkey analogy.
So true, as well. Our thoughts are truly the most powerful force in creating either the life of our dreams OR the life of our nightmares.
I'm gonna go give my monkey a hug and tell him to go play in the garden now. 🙂
Well put, Mike!
Haha, that'll make your monkey happy 😉
Hi Maria – really helpful post, especially regards that pesky monkey:) Thanks
Thank you Mark!
Very cool. Most posts talk about ditching the monkey. You suggest we master it.
Is it purely metaphorical? Or do you believe we should "master the monkey" cuz there are times we may need to use it?
I instantly thought of Peter Gabriel's "Shock the Monkey" and Aerosmith's "Monkey on my back" 🙂
Hi Blaine,
I believe the money (the ego) always will be a part of our life. But we decide how much. By mastering him, we can allow him work for us, instead of against us. I don't believe he wants to lead the way, he just wants to make sure we step in and take control 🙂
Thanks for your comment!
Hi Blaine,
Thanks for your comment!
I believe that the monkey (the ego) always will be a part of our life. Our job is to stop making it work against us, and instead, allow it to work for us. Ditching it might work, but that usually just ends up with the noise getting louder. So, not really sustainable (plus it makes you feel pretty insane when you think one thing and then do another). ) Instead of dismissing it and pushing it away, I believe it's way more powerful to actually allow it to be there. To acknowledge it and learn how to master it.
Thanks Maria, for this truly insightful and action oriented piece.
I think the greatest challenge, to taming the Monkey, is getting to "Detachment" most folks have come to a state where the Monkeys voice "Cloaks" their own voice and they erroneously believe that "The Monkey is Me"
Exercises that aid the detachment process would go a long way…I especially love the visualizing part of patting the Monkeys head.
Love your piece, you just won a heart in Nigeria.
Hi Benjamin,
Thanks a lot for your very nice comment!
I couldn't agree more. It's so easy to believe that we are our thoughts. And it's such a relief to realize that they simply are thoughts – not the truth or who we are.
Again, thanks for your last sentence. It made my day and warmed my heart 🙂


text:
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Last week I had the pleasure of meeting with students at the University of Tulsa. The screenwriting program organizes this Agents' Summit biannually to give students, faculty, and interested community members the chance to meet agents – real live agents! – and learn about the ins and outs of finding representation for your book, screenplay, or theatrical play.
Or, as the coordinating professor told me, "Now our students get to see that you aren't scary!"
He continued, "We want them to take their work seriously and understand its potential. We want them to realize they can apply for internships! We want them to keep writing!"
The visit was a very inspiring experience – the campus was beautiful, downtown Tulsa is full of amazing coffeeshops and interesting museums, and most importantly, the students were so bright, interested, and creative. They asked smart, thoughtful questions, like "What one quality are you looking for most in a query?"* and "How much should I change my book to fit what is popular right now?"**
It was a great reminder that in the daily grind of answering emails, reviewing contracts, and evaluating proposals, I also get to work with gifted writers who love putting stories on paper and sharing them with readers. Even when it's hard or lonely work, even when they have to be brave enough to share the results of that work with "not scary" agents like me! And it's exciting to know that there are a bunch of young writers out there getting ready to follow in their footsteps.
What questions have you always wanted to ask a "real live agent"? What keeps you motivated to work on your writing when you get discouraged?
*We all said things on the variety of "Voice!" and "Characters we can't forget about."
**Not at all! It's important to be familiar with your category and think about where you would find your readers…but it's also important to write the best book you can write, based on the inspiration that's driving you. Don't chase the market – it might be gone by the time you get there, and then you'll be stuck with a book you aren't invested in.


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July 3, 2009
I got a print of this piece from a friend of mine. I couldn't confirm, but I believe Romero Britto did this on the day of or within the few days after Michael Jackson's death last week. If you know Britto's work, then you know this is his trademark stuff. If I see that he's selling any prints/reproductions of this anywhere, to the public, I will definitely keep you updated.
CategoriesMiami Art


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Question about Bosch Classixx WVF 2402 Front Load Washer/Dryer
I need to clean the lint from the back wall of the dryer, I can see it all in there but there doesnt seem to be a way to get it out. I think it is delaying the drying time.
Posted by jaycee23 on
i dont think i can use a leaf blower or a vacuum attatchment pack, so any more ideas will be great. It sucks paying so much for a dryer that doesnt allow you to clean the lint out easily
This will definitely delay the drying time, and is also a severe fire risk!
If you are able to, it is sometimes best to replace the line, if it is the flexible line. If aluminum, you need to get a proper fitting attachment for your shop vac, or vacuum cleaner.
Either way there are products out there, if you don't have an attachment that will fit.
Here is one link, and there are many others available!
Good luck!
Posted on Aug 03, 2008
I also found this article from another person that had similar problems! Check it out!
So, your lint is in the dryer itself?
You will need some sort of thin attachment to remove it.
You could do the leaf blower trick, by blowing from the back exhaust of the dryer into the dryer, the big problem here, is you will have a laundry room full of lint!
Good Luck, Brian.
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OF Matt Szczur (Lower Cape May Regional) and the Tennessee Smokies (Cubs) play the Birmingham Barons (White Sox) Thursday in the first game of a best-of-five Southern League playoff series. Szczur hit .281 (143-for-509) with 78 runs scored, 44 RBIs and 22 stolen bases on 34 attempts in 128 regular-season games.
OF Darren Ford (Vineland) and the Indianapolis Indians begin their triple-A International League best-of-five playoff series with the Durham Bulls (Rays) Wednesday. Ford hit .230 (55-for-239) with 19 RBIs, 36 runs scored and 29 stolen bases on 40 attempts in 83 regular-season games. He struck out 56 times, and his on-base percentage was .307. He hit seven doubles, two triples and two home runs.
RHP A.J. Holland (Holy Spirit) and the Lynchburg Hillcats will begin their Class-A Advanced Carolina League best-of-three playoff series with the Potomac Nationals on Wednesday. Holland finished the regular season 5-9 with a 4.80 ERA in 28 appearances, all but the last five of which were starts. In 120 innings, he allowed 130 hits, walked 59 and struck out 79.
LHP Scott DeCecco (Middle Township) finished 10-9 with a 4.26 ERA in 27 starts this season. He made 24 starts for the Clinton LumberKings in the single-A Midwest League before being promoted to the High Desert Mavericks (Mariners) in the Class-A Advanced California League. The left-hander went 1-1 with a 2.55 ERA in three starts after his promotion. In 150 innings overall, he gave up 153 hits, walked 46 and struck out 92.
RHP Darren Fischer (Cumberland Regional) went 0-3 with a 5.30 ERA in 12 relief appearances this season for the Princeton (W.Va.) Rays in the rookie-level Appalachian League. In 18 2-3 innings, he allowed 12 hits, walked seven and struck out 17.
Independent leagues (unaffiliated with MLB)
OF Alexi Colon (St. Augustine Prep) went 0-for-3 with a run scored for the Schaumburg (Ill.) Boomers in a 3-1 victory over the Juliet Slammers in the Frontier League on Tuesday. Colon, an outfielder, is hitting .258 with five home runs, 31 RBIs, five triples and 34 runs scored in 79 games. The Boomers' regular season ends Thursday, and they open the playoffs with a best-of-five series Saturday against an opponent yet to be determined.
RHP Charlie Law (Mainland Regional) went 3-4 with a 3.20 ERA in seven starts for the Rockland Boulders in the Can-Am League. In 39 1-3 innings, he gave up 39 hits, walked 28 and struck out 21.


text:
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text:
510 pages, Illus
Provides a thorough synthesis of one of the classic transitions of evolutionary history, by utilising the integration of modern systematic methods with studies of functional and physiological processes.
...the editors are to be congratulated on a job well done... the volume offers most welcome insights... --TREE "Careful editing and the focus on integrated, comparative analysis of a single group keep this book from sharing the journal-issue fate of most technical symposium volumes." --CHOICE "This book represents the first, broadly integrated look at the anatomical and physiological changes correlated with the origin of amniotes as evaluated against the cladistic relationships of the pertinent taxa." --TRENDS IN ECOLOGY AND EVOLUTION "...includes a very thorough review of the relevant evidence of relationships between fossil forms, but extends well beyond that. This thorough and profound integration of palaeontological and zoological approaches to the subject is one of the strengths of this symposium. Another is the breadth of coverage that results. This is going to be the standard reference on its subject for many years." --BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY "...this book goes beyond skeletal anatomy and phylogeny to explore many other facets of the transition from amphibious to truly terrestrial existence. ...the contributors have made a concerted attempt to generate testable hypotheses, and the editors have done an admirable job of tying this diverse range of topics into a coherent work. This volume will make a significant contribution to the construction of a research program for the future." --AMERICAN SCIENTIST "The editorship of Stuart Sumida and Karen Martin deserves great praise for a job well done. There is a wide number of areas covered, and most vertebrate palaobiologists will find something to enjoy or contest. This volume could well be of great use to physiologists in placing their field in a more holistic, certainly historical perspective. The origin of amniotes really is one of the most fundamental areas of vertebrate evolutionary studies and this book is a welcome addition." --GEOLOGICAL MAGAZINE (1999)
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text:
Committed, For Now...
Name: Kerry Franks
Nickname: K.J.
Birthday: 8-16-85
High School: West Orange Stark
Head Coach: Dan Hooks
School Nickname: Mustangs
High School Position: Running Back/Defensive Back
Projected College Position: "Anywhere Expected"
Height: five-foot-ten
Weight: 185
Speed (40 yards): 4.24
Speed (100-meters): 10.4
Bench Press: 230-lbs
Squat: 340-lbs
Vertical Leap: n/a
Shuttle: n/a
Planned Major: Criminal Justice
Offensive Stats in 2002: 1,263 yards on 173 carries with eight touchdowns; four receptions for 27 yards; 283 yards on kickoff returns with one touchdown; 305 yards on punt returns with one touchdown
Defensive Stats in 2002: 21 tackles (11 solos and 10 assists) with one fumble recovery, one caused fumble, six tackles for losses, 26 passes broken up, one interception and four blocked kicks
Five College Favorites: Texas, Texas A&M, Penn State, Colorado, LSU
College Summer Camps you plan to attend: Texas, LSU, Texas A&M
Favorite College Team: Texas
Parents attended college at: Oklahoma State
Brothers/Sisters attending or graduated from college?
Where?: Sister at Texas


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