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Select ModelM1BM2B
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Select Waist SizeSmall (28-32")Medium (33-38")Large (39-44")XLarge (45-50")
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This new, inside-the-pants, belt-type concealment holster allows you to carry your gun without the need to wear a jacket. Nothing shows on the outside. There is no "give-away" clip to reveal you are carrying a concealed weapon or limit how low on the waistline you can place your handgun. The design holds the gun very close to your body for maximum concealment. The Defender is a quality holster designed for no-nonsense, practical everyday use.
You can effectively carry, completely concealed, from large frame semi-autos and revolvers to small .25 caliber pistols and everything in-between, along with extra ammo, without a jacket! Allows you to have immediate access to your gun. Allows for a smooth, fast draw. Gun can be positioned anywhere around waist. It will solve your concealment needs for several guns at one low price, saving you money.
Black Made in the USA.
Defender Concealment Holster—$34.99
DefenderDesigned by us over 25 years ago. Copied countless of times by other companies. Still the best and the only one with a Lifetime Guarantee!
Self-Defense Guideline Card!The steps you must take to keep from going to prison if you use your gun in self-defense.
ITP Holsters - People Also Viewed
Hybrid Defender Holsters
ITP Middle of the Back (MOB) Concealment Holster
Tuckable ITP ActionDraw Holsters
Fits Micro frame guns: .22s, .25s and .380s:Ruger LCP, Kel-Tec P32 and P3AT, NAA Guardian's, Kahr P380, SIG P238, Taurus P738. Also fits above guns with Crimson Trace Laser.
Fits Compact to large frame guns: .380, 9mm, .40 and .45 autos and revolvers. Also fits guns with Crimson Trace Laser.
Adjustable Thumb BreakDeluxe thumb break with steel stiffener provides security, plus super fast access to your gun. Fully adjustable.$4.99
What is a Thumb Break?
Adjustable Dual Magazine CarrierNow you can put two extra magazines/speed strips or a handcuff anywhere around your waist. With an adjustable dual magazine holder, you have the option to place them exactly where they feel more comfortable to you and for faster access.
Dual Magazine/Speed Loader Carrier—$7.99
MODEL M1B:Small size guns such as:
Autos— .22, .25 and .32 caliber handguns: Beretta's Bobcat & Tomcat, Kahr P380, Kel-Tec P-32 & P-3AT, NAA Guardian's, Raven Arms, Ruger LCP, Seecamp's, Taurus PT-22, PT-25 and many other similar sized guns.
MODEL M2B:Medium to large guns such as:
Autos— AMT Backup .45-- Astra A-75 -- Beretta 9000's, Cheetah & Px4 Storm -- Browning Pro & Hi Power -- Colt 1911 All Models -- GLOCK 17,19, 26, 27 -- H&K Compacts -- Kahr -- Kimber -- Para Ordance -- S&W Sigma series, SW99, M&P, 410, 457, 908, 910, 3913, CS Series -- Sig Sauer P228, P230, P239 -- Springfield Armory 1911's & XD's -- Taurus Model 92, 100, 24/7 & Millennium series -- Walther PPK/s and many other similar sized guns.Revolvers—Small J-Frame 5 shot, 2-3" barrel revolvers: Charter Arms Off-Duty, Undercover, Bulldog, Mag Pug & Pathfinder -- S&W J-Frame All Models -- Colt Detective Special -- Rossi -- Ruger LCR, LCRx, SP101 -- Taurus Model 17, 605, 650, 85, 850, 851 -- and many other similar sized guns.
Putting on the Defender for the ultimate in concealment.
The Defender is an inside-the-pants, belt-type holster. It should be worn UNDER outer garments but OVER under garments. The preferred way to wear the Defender is just below the waist line with the top edge of the holster level with the top edge of the regular dress belt. At this position, the butt or grip of the gun will be above the waist line. It can also be worn lower on the hips to completely conceal the gun. In both instances the tension from your clothes and belt will hold the gun close to your body and make the gun "disappear". The gun may be positioned anywhere around waist .
Wrap the Defender around the waist as you would a belt, with the top edge level with your belt line and secure fastener. (Fig. 1)
Position the gun pouch where you wish to locate the gun. (Fig. 2)
Insert gun into pouch and extra magazine or speed strip into magazine pocket. (Fig. 3)
Put on outer garments and adjust the Defender for ultimate comfort and concealment. (Fig. 4)
Small Of Back
Cross Draw
Custom DefendersAs easy as 1, 2, 3...
The standard Defender is a very versatile holster which can position your handgun for almost any kind of draw from strong hand side, groin area, cross draw or small of back.
If, however, you need a custom Defender, it can be made to your exact specifications. They are made to order and take 7 to 10 extra days for delivery. There is an additional $10.00 charge for custom orders.
Custom configurations available include: Small of Back with tilt, Cross draw with tilt, FBI tilt, thumb break, larger than standard waist sizes. Adjustable extra magazine and handcuff holders are also available at an extra charge. Please indicate anything special you would like to add in the comments section on the online checkout form or email us. (You must include your order confirmation number which will appear after you have completed the online checkout process.) Any other configurations or questions please call.
#DEF-C Custom Defender—$44.99
Conditions: These holsters are non returnable except for defects in construction or materials. All holsters come with standard retention strap. Thumb break retention strap available for additional $4.99.
1. Qty:
2. Waist Size: In inches. Please use measuring tape.
3. Model and ColorM1B-BlackM2B-BlackM1B Left Hand-BlackM2B Left Hand-BlackM1B-WhiteM2B-WhiteM1B Left Hand-WhiteM2B Left Hand-White
4. Custom FeatureRegular PocketSOB w/tiltCrossdraw w/tiltFBI TiltLarger Waist Size
Quantity Thumb Break (Add $4.99 each)
Dual Single Stack Magazine Holder (Add $7.99 each)
Dual Double Stack Magazine Holder (Add $7.99 each)
Our Customers are our most important critics. So we let them do the talking...
Click for more reviews
People who put their lives on the line everyday depend on the Defender. Our satisfied customers include members of:
n Air Marshalsn U.S. Secret Servicen BATFn Private Investigatorsn Miami, New York City, Sacramento Police Depts. and others nationwiden JFK Airport Security and others nationwide
"I have gone through many holsters, and I keep going back to the Defender. I carry my Kahr PM9 as routinely as I wear shoes, and it is so comfortable that I sometimes reach back behind my hip to make sure it is there. The concealment is far superior to anything else I have tried, as it holds the gun close to my body and flat. Drawing is the same as any inside the waistband holster, with a shirt hanging over or tucked in. I don't know why I kept trying other holsters."J.B., Idaho Falls, ID
"I'm not in the habit of writing vendors to comment on their product, but I was so impressed with my new Defender holster I felt obligated. My carry gun of choice is a Glock 19 but finding a concealed holster that was comfortable and unobtrusive was proving difficult. With summer coming, I was looking for something I could wear with shorts and a t-shirt. Fortunately, I stumbled across your website. I admit that I read the testimonials from your other customers with a very large grain of salt, but with your no-questions-asked return policy, figured I had little to lose.Well, the Defender was everything you said it was! It's so comfortable I almost forget I'm carrying and the Glock just disappears! I'm so satisfied with your product and service that I just purchased a wallet holster from you for my Kel-Tec P-32. You can also be sure that I'll be recommending you to all my friends. Thanks again!"L.W., Frisco, TX
"I carry a Colt .45 US 1911 80 series and a S&W .357. Both of these sidearms are heavy and bulky. I have hip, shoulder, and SOB holsters. In each case, the weight and size of these guns present a problem of comfort and concealability. With your holster I find that it is quite comfortable to carry either. With the grip just above my belt-line covered only by a shirt or vest I feel assured of concealment. I also find that by simply pushing the grip down below the belt, these large pistols are hardly noticeable even without a top-cover. Very convenient, living as I do in Florida."L.W., Tampa, FL
"I received my Defender holster today! Man talk about service! I placed my order on 12/27/2000 at approximately 10 pm and got it on 1/02/2001. Five days with a holiday thrown in! Not only is the service great, so is the holster. I have worn the holster with a compact S&W 9mm for about seven hours and had only a golf shirt on. Even my wife could not tell I was carrying a gun. Also I almost forgot I was carrying because of the way the holster distributed the weight... Just as advertised!"D.B., Rock Mart, GA
"The Defender Holster is the finest holster I have ever owned. I use it 24/7 for off duty concealed carry, it is very comfortable and does not shift like other holsters. I also use it while running and mountain biking."R.L.B., Iowa State Trooper
"Your product is great! The Defender holster is quite comfortable and secure. And it allows me to go out with just shorts on."N.B., Cabin Creek, WV
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What's interesting is that CBS showed the accident. Was reporting on it etc. They pretty much stopped the parade coverage to cover the accident, whole NBC didn't mention it at all....
I say the FCC should crack down hard on this deliberate deception of the American public!
The thing that irritates me is the fact that money will be wasted to figure out what went wrong in the parade.
Seems kinda obvious. Wind go whoosh, ballon go bye bye and hit light fixture, light fixture fall down go boom.
To report on it would have violated the "Perky One"'s contract.
There is a clause in her contract that says that she will not participate in any story that requires her not to be perky. The only exception in that clause is when she is bashing Bush or conservatives. At which time she can switch from Perky mode to attack dog mode.
NBC= No Business Communicating
Fake but accurate.
But, the story was essentially correct, even though the evidence may have been falsified. The balloon DID cross the finish line -- last year. NBC was merely showing it's (fewer and fewer) viewers what that looked like. To the increasingly irrelevent MSM, if the evidence onflicst with "the story", the story wins.
This is just bizarre. I saw it, too. Actually, I can't stand the perky one, so I turned on CBS. They had Dave Price, who used to be on FOX AM news in NYC. So I turn it on, they've got some sort of incident. I check NBC to see what they are doing, and it's like nothing's wrong. You would think they would WANT to cover the balloon wreck.
NBC News of the exploding truck fame.
It's Bush's fault.
This was an entertainment show, with a large audience of children. There was no need to interrupt the script of Santa's arrival with an incomplete 'news bulletin'.
Un-bunch, willya?


text:
A state Senate bill to open records in the governor's office cleared its first legislative hurdle Wednesday.
Senate Bill 57 by state Sen. Robert Adley, R-Benton, would lift restrictions on public access to records on pre-decisional advice and recommendations to the governor on budget matters.
The legislation also would open the door on records the governor claims are off limits because they relate to "executive deliberations."
Communications between the governor and his immediate staff still would be private as would be security details on the schedules of the governor, his spouse and children.
The Senate and Governmental Affairs Committee voted without objection to advance the bill to the full Senate.
Adley told the panel that he tried for years to define deliberative process. The Jindal administration often denies public records requests by claiming they involve deliberative process.
Deliberative process involves information the administration weighs to make decisions.
For example, the administration contends documents involving the possible privatization of a state employee health plan are off limits.
Adley said he finally decided to remove deliberative process from the law altogether.
Liz Murrill, deputy executive counsel to the governor, said legislators cannot just write deliberative process out of the law. She said the issue involves a constitution-based discussion.
Murrill said many decisions are not finalized until they come through the public process.
Carl Redman, executive editor of The Advocate, told the committee that the governor's office enjoys more secrecy because of changes made to the public records law during Gov. Bobby Jindal's administration.
He said deliberative process is being invoked across state government.
"Deliberative process is creeping down from the fourth floor into other agencies," Redman said, referring to where the Governor's Office is located in the State Capitol.


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University in European Union
Descripion of the MA Programme
The European Union-Russia Studies MA-programme (EURUS) is a unique multidisciplinary programme combining different disciplines such as political science, (comparative politics, international relations) economics, law, history and cultural studies.
The programme integrates not only different disciplines but it also binds together the study of two main regions in one coherent curriculum, giving a comprehensive understanding about the political, social and economic developments in the European Union and its member states as well as in Russia and its neighbouring countries in Eastern Europe and in the Caucasus (Belarus, Ukraine, Moldova, Georgia, Armenia, and Azerbaijan).
The Master programme EURUS hence focuses on the understanding of the development of and the relationship between the EU, being a political and an economic entity "sui generic" on the one hand, and the Russian Federation on the other hand, including Russia's close neighbours to the West and to the South mostly aiming at accession and full membership in the European Union.
After gaining your MA degree from the EURUS programme, both public and private sector job offers are open for graduates. Expertise in both EU policy making and Russian politics, combined with in depth historical analysis, supports the graduates in thier career development and excellent future prospects. Those interested in further research are also eligible for proceeding to PhD studies.
Photo by Gertu Timmusk.
EURUS and European Studies master programme's students at European Parlament Information Office in Tallinn (Estonia).
Simulation of EU Institutions and Policy Making.
What does EURUS offer?
- Thorough, comprehensive and up-to-date knowledge of policies and politics, of economics, law, and history of the European Union and the Russian Federation;
- Academic qualification for successfully taking up challenging tasks in dealing with the EU, Russia and their mutual relations;
- Professional competence for advancing political, commercial, and cultural dimensions shaping the future development of the European Union and the Russian Federation;
- Two specialization modules, which deepens the knowledge about the European Union policies and politics or Russian social and political developments;
- Knowledge of a foreign language (Russian or one of the European languages) is needed for a chosen field of future professional employment, voluntary internship in a governmental institution, private enterprise or non-governmental organisation;
- Interactive and innovative teaching and strong individual tutoring during the study process, is combined with a broad range of qualified supervisors from different study disciplines;
- Multicultural classroom and international faculty members with specially designed study methods. A number of study-related outside class activities, e.g. film series, study trips, public lectures etc.


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MD-2 Mega Distortion reviews— 24 total
- Sound: 8.4
- Overall Impression: 8.7
- Reliability & Durability: 9.6
- Ease of Use: 9.2
Users' score:
(173 votes)
24 user reviews of MD-2 Mega Distortion by Boss
But the lesson in that is that there is a very attractive used market for under-appreciated gear, and the MD-2...
I have played guitar for 3-4 years now, and this is my first time I've been playing with a guitar...
I've been playing for about a year, and this is my only pedal so far.
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Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
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P-glycoprotein is a blood–brain barrier efflux transporter involved in the clearance of amyloid-beta from the brain and, as such, might be involved in the pathogenesis of Alzheimer's disease. P-glycoprotein is encoded by the highly polymorphic ABCB1 gene. Single-nucleotide polymorphisms in the ABCB1 gene have been associated with altered P-glycoprotein expression and function. P-glycoprotein function at the blood–brain barrier can be quantified in vivo using the P-glycoprotein substrate tracer (R)-[11C]verapamil and positron emission tomography (PET). The purpose of this study was to assess the effects of C1236T, G2677T/A and C3435T single-nucleotide polymorphisms in ABCB1 on blood–brain barrier P-glycoprotein function in healthy subjects and patients with Alzheimer's disease.
Thirty-two healthy subjects and seventeen patients with Alzheimer's disease underwent 60-min dynamic (R)-[11C]verapamil PET scans. The binding potential of (R)-[11C]verapamil was assessed using a previously validated constrained two-tissue plasma input compartment model and used as outcome measure. DNA was isolated from frozen blood samples and C1236T, G2677T/A and C3435T single-nucleotide polymorphisms were amplified by polymerase chain reaction.
In healthy controls, binding potential did not differ between subjects without and with one or more T present in C1236T, G2677T and C3435T. In contrast, patients with Alzheimer's disease with one or more T in C1236T, G2677T and C3435T had significantly higher binding potential values than patients without a T. In addition, there was a relationship between binding potential and T dose in C1236T and G2677T.
In Alzheimer's disease patients, C1236T, G2677T/A and C3435T single-nucleotide polymorphisms may be related to changes in P-glycoprotein function at the blood–brain barrier. As such, genetic variations in ABCB1 might contribute to the progression of amyloid-beta deposition in the brain.
KeywordsBlood–brain barrier P-glycoprotein ABCB1 MDR1 Polymorphisms (R)-[11C]verapamil PET
P-glycoprotein (Pgp) is a 170 kDa membrane-bound efflux transporter located in several organs throughout the body with an excretory and/or barrier function, such as the liver, kidneys, intestine, placenta, testes and the blood–brain barrier (BBB) [1]. At the BBB, Pgp is highly expressed and has an important function in the transport of a wide variety of endogenous and exogenous substances out of the brain into the bloodstream [2]. Pgp has been shown to play a role in amyloid-beta clearance from the brain and, as such, has been hypothesized to be involved in the pathogenesis of Alzheimer's disease (AD) [3]. Recently, BBB Pgp dysfunction in AD patients was shown using the Pgp substrate tracer (R)-11C]verapamil and positron emission tomography (PET) [4].
Pgp is encoded in the ABCB1 gene (formerly known as the multidrug resistance (MDR1) gene), which spans 28 exons that code for 1280 amino acids and is located on chromosome 7q21 [5]. The ABCB1 gene is highly polymorphic, and to date, over a hundred single-nucleotide polymorphisms (SNPs) of this gene have been discovered [5]. The majority of SNPs are either intronic or non-coding. Only a minority of variants in the coding region lead to a change in amino acids [5, 6].
In Caucasian subjects, high SNP frequencies in ABCB1 were observed for 3435T in exon 26 (54%) and 2677G in exon 21 (56%). High SNP frequencies were also found for 2677T (42%) and 1236T in exon 12 (46%) [5, 7]. Of the 15 most frequently occuring SNPs, the synonymous variant (no amino acid exchange) C1236T (rs1128503), the non-synonymous variant G2677T/A (amino acid exchanges Ala893Ser or Ala893Thr) (rs2032582) and the synonymous variant C3435T (rs1045642) are most widely studied regarding their consequences for Pgp function and/or expression [5, 6].
Altered transport function of Pgp was observed for the C3435T SNP, as the 3435T allele was associated with decreased Pgp expression in the duodenum, and increased oral bioavailability of the Pgp substrate digoxin [8]. On the other hand, others could not replicate these findings, and even opposite effects of this SNP have been shown [9, 10]. Whilst in vitro studies did not find effects of the G2677T/A SNP [11, 12], another study showed an association with decreased Pgp expression in the human placenta [13].
Highly significant linkage disequilibrium was shown among exons 12 C1236T, 21 G2677T and 26 C3435T, which could account for most of the haplotypes (combinations of SNPs) seen in ABCB1 [13, 14, 15]. To date, two studies have assessed the effects of ABCB1 haplotypes on BBB Pgp function using PET and 11C]verapamil. In these studies, healthy subjects with the homozygous TTT haplotype (1236T, 2677T and 3435T) did not differ in brain distribution of 11C]verapamil from subjects with the homozygous CGC haplotype (1236C, 2677G and 3435C) [16, 17].
As Pgp is involved in amyloid-beta clearance at the BBB, genetic variations in ABCB1 might be related to an inherited change in the risk of developing AD [3]. Analysis of ABCB1 SNPs in combination with in vivo measurement of BBB Pgp function in AD is needed to further evaluate this hypothesis. Therefore, the purpose of this study was to assess the effects of C1236T, G2677T/A and C3435T SNPs on BBB Pgp function in both AD patients and healthy subjects.
Thirty-two healthy controls and seventeen AD patients were included in this study. All participants underwent a standardized clinical assessment, including medical history, family history, use of medication and drugs of abuse and physical and neurological examinations. All subjects had normal scores on screening laboratory tests. Medication at the time of scanning was not allowed, except for medication known not to interfere with Pgp function [18, 19]. Controls fulfilled research criteria of never having been mentally ill, and they had normal brain magnetic resonance imaging (MRI) scans and Mini-Mental State Examination (MMSE) scores within the normal range (MMSE > 26) [20]. For AD patients, a clinical diagnosis of probable AD was established by consensus in a multidisciplinary meeting according to the criteria proposed by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association [21]. Increased cortical accumulation of 11C]PIB PET was required to confirm presence of amyloid pathology in the brain [22]. Written informed consent was obtained from all participants after a complete written and verbal description of the study, and the study was approved by the Medical Ethics Review Committee of the VU University Medical Center.
Participants underwent structural MRI scans using either a 1.0-T Magnetom Impact scanner (Siemens Medical Solutions, Erlangen, Germany) or a 1.5-T Sonata scanner (Siemens Medical Solutions). The scan protocol included an identical coronal T1-weighted 3-D magnetization-prepared rapid acquisition gradient-echo sequence, which was used for co-registration and region-of-interest (ROI) definition.
All PET scans were acquired using an ECAT EXACT HR+ scanner (Siemens/CTI, Knoxville, TN, USA) [23]. Participants received an indwelling radial artery canula for arterial sampling and a venous canula for tracer injection. After a 10-min transmission scan in 2D acquisition mode, which was used to correct the subsequent emission scan for photon attenuation, a dynamic 3D emission scan was started simultaneously with the injection of 369 ± 19 MBq (R)-11C]verapamil, administered using an infusion pump (Med-Rad, Beek, The Netherlands). The 60-min emission scan consisted of 20 frames with progressive increase in frame duration. Arterial blood was withdrawn continuously using an online sampling device (Veenstra Instruments, Joure, The Netherlands) [24]. At set times, continuous sampling was interrupted briefly, and manual samples were taken. A detailed description of scanning and sampling procedures has been reported previously [4].
PET data analysis
All PET sinograms were corrected for dead time, tissue attenuation, decay, scatter and randoms. PET scans were reconstructed using a standard filtered back projection algorithm, applying a Hanning filter with a cut-off at 0.5 times the Nyquist frequency. A zoom factor of 2 and a matrix size of 256 × 256 × 63 were used, resulting in a voxel size of 1.2 × 1.2 × 2.4 mm and a spatial resolution of approximately 6.5 mm full-width at half-maximum at the centre of the field of view. Co-registration of structural T1 MR images with corresponding PET images and segmentation of the co-registered MRI into the grey matter, white matter and cerebrospinal fluid was performed using statistical parametrical mapping (SPM, version SPM2, http://www.fil.ion.ucl.ac.uk/spm, Institute of Neurology, London, UK). ROIs were defined on the basis of the segmented MRI and a probabilistic template as implemented in PVElab [25]. ROIs were mapped onto dynamic PET images, generating regional time-activity curves. A global cortical region was defined consisting of the volume-weighted average of the frontal, parietal, temporal and occipital cortices and posterior and anterior cingulate regions [4].
The original on-line blood curve was calibrated using whole blood radioactivity concentrations derived from the manual samples. The calibrated whole blood curve was multiplied with a single-exponential fit to the plasma-to-whole blood ratios of these samples, thereby generating a total plasma curve. Finally, the metabolite-corrected plasma input function was obtained by multiplying this total plasma curve with a sigmoid fit to one minus the polar metabolite fraction [26, 27].
Kinetic analyses were performed using software developed within Matlab 7.04 (The Mathworks, Natick, MA, USA). (R)-11C]verapamil data were analysed using a previously validated constrained two-tissue compartment plasma input model [28]. The non-displaceable binding potential (BPND) was used as outcome measure. Again, data analysis and kinetic modeling procedures have been described in detail elsewhere [4].
DNA isolation and molecular analysis
The DNAs of 49 samples were isolated from 4 mL of frozen blood samples using the Gentra Puragene Blood Kit (Qiagen, Hilden, Germany) according to the manufacturer's protocol. C1236T, G2677T/A and C3435T polymorphisms were amplified by polymerase chain reaction (PCR) using the following conditions: 12.5 ng DNA; 1X PCR buffer; 0.2 μM of each dNTP; 0.7 μM of each primer (C1236T F: 5′-TTGAATGAAGAGTTTCTGATGTTTTC-3′, R: 5′-CCTGTCCATCAACACTGACC-3′; G2677T/A F: 5′-TTCTCTAATTTGTTTTGTTTTGCAG-3′, R: 5′-AAAAGATTGCTTTGAGGAATGG-3′; C3435T F: 5′-GTGTGCTGGTCCTGAAGTTG-3′, R: 5′-AGAGAGGCTGCCACATGC-3′); 2 mM MgCl2 and 0.03 u of Fast Taq polymerase (Roche, Basel, Switzerland) 5-min initial denaturation at 95°C; 35× cycles at 95°C denaturation for 30 s, 58°C annealing for 30 s and 72°C extension for 30 s, and a final extension at 72°C for 10 min. The resulting PCR products were purified by SAP/Exo treatment (GE Healthcare, Little Chalfont, UK), and both strands were sequenced using the Big Dye Terminators v3.0 Sequencing Kit (Life Technologies, Carlsbad, CA, USA) on ABI 3730 (Life Technologies, Carlsbad, CA, USA) and analysed using Seqscape software (Life Technologies, Carlsbad, CA, USA).
Statistical analysis
Statistical analyses were performed using SPSS 15.0 (SPSS Institute, Chicago, Ill, USA). Values are presented as mean ± standard deviation (SD). Differences in BPND between groups were assessed using non-parametric Mann–Whitney U tests. A general linear model (GLM) with T dose as the continuous measure was used to assess the effects of T dose on BPND. The threshold for significance was set at p < 0.05.
Thirty-two healthy controls (14 females) with a mean age of 47 ± 17 years and seventeen AD patients (5 females) with a mean age of 64 ± 7 years were included in the study.
Prevalence of different SNPs in healthy controls and Alzheimer's disease patients
11 (34%)
3 (18%)
11 (34%)
8 (47%)
10 (31%)
6 (35%)
10 (31%)
3 (18%)
10 (31%)
8 (47%)
10 (31%)
6 (35%)
8 (25%)
2 (12%)
15 (47%)
9 (53%)
9 (28%)
6 (35%)
Global (R)-[11C]verapamil BPNDin healthy controls and Alzheimer's disease patients after dichotomization on presence of T
no T
1.76 ± 0.45
1.74 ± 0.33
T present
1.78 ± 0.43
2.16 ± 0.29*
no T
1.76 ± 0.45
1.74 ± 0.33
T present
1.78 ± 0.43
2.16 ± 0.29*
no T
1.73 ± 0.49
1.56 ± 0.15
T present
1.79 ± 0.42
2.15 ± 0.28*
In healthy controls, no effects of SNPs in C1236T, G2677T/A and C3435T on Pgp function at the BBB were found in vivo. In contrast, in AD patients, both the presence of T as well as T dose in C1236T, G2677T/A and C3435T were related with increased BPND of (R)-[11C]verapamil, suggesting decreased Pgp function at the BBB.
Two previous PET studies, assessing effects of ABCB1 haplotypes on BBB Pgp function in healthy subjects, also did not find differences in the brain uptake of 11C]verapamil [16, 17]. Before the present study, however, no studies have been performed assessing effects of genetic variations in ABCB1 on in vivo BBB Pgp function in AD patients.
The present study showed a selective effect of the C1236T, G2677T and C3435T SNPs in ABCB1 on BBB Pgp function in AD patients. As, using (R)-11C]verapamil PET, BBB Pgp dysfunction in AD patients has been shown previously [4], the present data suggest that genetic variations in the ABCB1 gene might affect Pgp function or expression at the BBB, only when Pgp function is already compromised. Therefore, in AD patients, genetic variations in ABCB1 could contribute to disease progression as an additional decrease in BBB Pgp function may lead to an increased rate of accumulation of toxic substances, such as amyloid-beta, in the brain. Alternatively, it is also possible that certain genetic variations in ABCB1 have a more primary role in developing neurodegenerative diseases such as AD or Parkinson's disease (PD). For example, in subjects that were exposed to organochlorine insecticides, polymorphisms in ABCB1, associated with decreased ability to clear xenobiotics from the brain, increased the risk of PD [29].
In the present study, the prevalences of different variants in C1236T, G2677T and C3435T SNPs in ABCB1 were comparable between AD patients and healthy controls. A previous pilot study in relatively small groups of demented patients and healthy subjects showed no significant differences in the prevalence of C1236T, G2677T/A and C3435T [30]. Nevertheless, a large population-based study would be needed to assess possible differences in prevalence of genetic variations in ABCB1 between healthy controls and AD patients. Only such a larger study could provide insight into the role of ABCB1 SNPs and haplotypes as a possible risk factor for developing AD. In a subset of such a study, BBB Pgp function should be measured to further evaluate the relationship between ABCB1 SNPs and haplotypes, and BBB Pgp function in both healthy controls and AD patients.
The prevalences of different variants in C1236T, G2677T/A and C3435T in this study were comparable to those reported previously [5, 7]. In addition, linkage disequilibrium between the three SNPs, observed in the present study, has also been described before [13, 14, 15]. It could very well be that the effects of the different SNPs in ABCB1 that we have found in AD patients are physiologically effectuated through the linkage disequilibrium via the G2677T SNP, which is a non-synonymous variant, thus changing amino acid sequence, while the mutations in C1236T and C3435T are synonymous [5, 6].
At present, measuring Pgp function at the BBB in vivo can only be performed using (R)-[11C]verapamil PET with arterial blood sampling. Consequently, group sizes in the present study are limited, and findings need to be replicated in larger trials, preferably using methods without arterial sampling. Another limitation of the present study is the fact that it is not possible to differentiate between decreased Pgp function due to decreased BBB Pgp transporter expression or decreased Pgp transport functionality with intact transporter expression. This can only be addressed when a PET tracer of Pgp expression becomes available.
Single-nucleotide polymorphisms in C1236T, G2677T and C3435T are related to changes in BBB Pgp function in AD patients, but not in healthy controls. As such, in AD patients, genetic variations in ABCB1 might contribute to the progression of amyloid-beta deposition in the brain.
We thank the PET radiochemistry and technology staff of the Department of Nuclear Medicine and PET Research for the tracer production and help with the acquisition of PET data and the technology staff of the Department of Radiology for the acquisition of MRI data. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 201380.
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Risky Business: Fund Backs Filmmaker
When a younger brother of once-highflying hedge-fund manager Alphonse Fletcher Jr. won a screenwriting Oscar in 2010 for the film "Precious," he thanked his siblings, saying they "supported me in every way."
Now a legal battle for control over hedge funds run by Fletcher Asset Management is showing the nature and extent of one sibling's support.
After winning the Oscar, Geoffrey S. Fletcher made his debut...


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LDD, an Acteon company, will be joining sister company MENCK to showcase their joint specialist marine foundation capabilities, amongst more than 1,000 exhibitors at WindEnergy Hamburg 2014. The new expo is focused on innovations in the global on- and offshore wind industry.
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Babich Marlborough Sauvignon Blanc 2014
Sauvignon Blanc
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Today, my mom let my younger brother borrow my car. He managed to crash it through the garage door. While I was in another country. Somehow, I manage to get berated by my mom because I'm not doing enough to make my brother feel better about him having an accident involving my car and my house. FML
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By awildwhisper | 27
Berate your brother back and make him pay you back, even if it takes years.
By Vanessa Ramirez | 3
Yea id make the Lil shit get a part time job and pay for it all. If your mom protests than she better pay for it.
Arashikage | 17
Wait what? How the flying platypus testicle is that your fault
By Brightbulb | 36
Maybe you Mom needs to learn that you having to file a claim on your insurance is going to haunt you for years on your premiums, insurance consumer score and, and even your consumer credit history. I wouldn't let it be water under the bridge either, she made the decision to let your brother use it, he made the decision to run it into the garage. While you made neither decision, and you are the only one losing anything in this. Make them both feel like doody for this, and I would try and get some reimbusement from them, at least for you deductibles.
By Medhavi Gupta | 6
Trust me everyone with siblings has to go through this phenomenon. It's global and sort of embedded into all parents' dna
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VideoHive Glitch & noise media FX 2059300
After Effects Project \ Video Displays \ Grunge
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Patriarch Alexy II philosophic about rumors of his death
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- http://www.interfax-religion.com/?act=news&div=2976
01 May 2007, 16:39
Patriarch Alexy II philosophic about rumors of his 'death' - patriarchal circle
Moscow, May 1, Interfax - Patriarch Alexy II of Moscow and All Russia
'treated philosophically' the rumors about his 'demise', Sergey
Kravets, director of the Orthodox Encyclopedia church research
center, told Interfax.
'I inform you that I am still alive', these were the words, according
to Kravets, with which the patriarch greeted him the day after
disturbing news appeared in some mass media.
Alexy II's first reaction to these rumors was 'a sincere astonishment
at the incompetence of some journalists', Kravets said adding that
'the patriarch began to wonder even more why the false report
continued to be replicated even after the official refutation'.
'Significantly, Patriarch Alexy, contrary to what has been reported
about him recently, has never undergone coronary artery bypass
grafting, nor has he survived an apparent death, though some wrote
there were even two of them. In other words, the only truth was that
the patriarch's name is Alexy', Kravets remarked.
He said on May 1 the patriarch, as was expected, would return to
Moscow and already on May 2 his rather tough schedule of divine
services and working meetings would begin.
He also shared his opinion that 'the mass media which put the
patriarch into an intensive therapy ward and hastened to 'bury' him
should apologize to the primate'.
Kravets described the rumors as 'absolute nonsense'. 'We will find
out if there was a malicious intent. But I would remind my colleagues
that they should learn to use the freedom of information they enjoy,
not to turn it into a phantom'.
In conclusion, Kravets noted that 'in popular belief, if a rumor
seeks to 'bury' a person, it means he will live a long life'.
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After being involved in the tiny house movement for the last several years we have been made aware of many of the major tripping points of designing and building your own custom tiny home.
The Planning Tiny Design Process:
We have tried to simplify the design process by asking a series of questions and providing the pros and cons of each choice so that you can flesh out your own 'best' design. You can learn more about these sorts of things:
- Pros and cons of particular roof styles
- Various styles and numbers of loft style
- Pros and cons of general layouts
- Ways to layout and customize a tiny house bathroom
- Ways to layout and customize a tiny house kitchen
- Ways to layout and customize a tiny house living area
- Tiny house bedroom options
- Selecting window and door locations and the decisions that go into that
- Finish material choices
- Appliance layouts desires
Who We Are:
Macy Miller – I run the website www.MiniMotives.com and started the construction of my tiny house in November 2011 and, just by an off chance, decided to blog about it. I went to school for architecture and my whole reason for that was to change the course of the environment. Our buildings produce 70% of all pollutants in the air, with small changes that can be impacted dramatically. I find there is a lot more potential to impact that change on a residential level and have gravitated toward a smaller footprint. For me, tiny was impacted by environmental concerns, financial limitations, the flexibility to live the life I want (which doesn't include a mortgage) and was a learning project. It IS possible to live tiny very comfortably and I hope to be able to help others make the choices needed toward that happier lifestyle. Aside from my passion for tiny houses I also enjoy staying home to raise our daughter, Hazel, taking our Great Dane, Denver, to the dog park to see his friends and all things artistic!! You may also catch me trying to learn the ways of the podcast over at tinyhousechat.com!
James Herndon – I am a Licensed Architect with a passion for technology and it's impact on the way we live in and design our world. I got my start flipping houses while working on my Masters degree in Architecture but have always had a passion for 3D modeling and more recently 3D printing, and augmented reality. My background is primarily in designing residential and commercial buildings but in recent years I've had some successes in product design and app development as well. I love to design and build across multiple mediums.
Macy and James met right around when she was roofing her tiny house and they spent a lot of their first dates building together.


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Ever wondered whether you can compose thing useful? You definitely have. It could have been an art piece, a novel, a enthusiasm good product, or simply thing that attracts people's admiration. And truthful in your mind, you had wished that you were the maker. But after whatever synthetical deductions, you realized that it was freshly a thought of your imagination! And you sheepishly let somebody know yourself that it is honourable over and done your skill. Most empire will just sign out it at that and never relocate on the far side the first idea. Fortunately, quite a lot of of us will not clutch it fraudulent descending and alternatively of surrendering, will or else furnace convey and variety their notion into a creation, be it an art piece, a book, or every inventions. Perhaps you did not consider up to the literary horizontal that the job required, but consequently again, you sure have heard of creators that were lowly civilised.
High informative flat is not a prerequisite for yeasty capabilities. Anyone can compile. You purely demand a enormously cheery noesis to thoroughgoing your creations, as within are heaps obstacles along the way. If you were to ask around, you will perceive a lot of ideas, but you will not confidently brainwave creations. You will obligation to go onwards the run-of-the-mill to be able to originate anything. Besides having a awfully complimentary attitude, you will too entail an probing heed. Not every formation requires vast ease of the question event. And with today's internet, you can efficiently discovery out property that you do not cognize around next to a few clicks of the mouse. You will demand to enlarge some force to find out astir things, as good as a lot of finding.
Inferiority complicated is the major idea why folks don't harass their planning to fruition. And they will usually outer shell circa to see whether in attendance is someone other who has finished it. Of module they can't insight everyone and so all their opening inspirations vanish into thin air! Here is a terribly useful stratagem that you can use to breed belongings pass off. It is as straightforward as informative yourself that 'you' yourself will do the impracticable and you will 'do' it. If you can't find any creators among your crowd, it would even be better, because you are active to do it and the portion of your faithful will honorable gall your formation.Post ads:
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But you asked what is nearby to create? Don't worry, as prolonged as in that is the will, you will insight it someway. After you have established that you will formulate something, your awareness will subconsciously wish out opportunities. You will likewise begin to outer shell at belongings differently, tho' you are not alert of it. The subsequent thing is to activate on the quirk of interrogative yourself 'why not this' and 'why not that'. The scheme is to put a lot of interview first baron marks of broughton in your brain. Let those questions bubble near for a patch. When the example is right, an statement will pop up from no where!
Here is another elbow grease to flabbergast you. Let us say you have not raddled any item since you closing left-hand college. Let us too presume that you are not at all dandy in chart and sculpture. Now, take a life-size hunk of illustration insubstantial and pin it on a improvised easel (you need quite a lot of imagination to extemporize this). Go and get yourself any crunchy new pastel colors, either from the neck of the woods ease of use mercantile establishment or the purchasing walkway. Now commencement drawing your magnum opus. But what idea to paint? No matter, freshly dear your view and fancy. You will see something and you will use the vegetation to coat an outlook (you don't condition to sketch a skeleton most basic) of what you saw in your heed. At eldest it possibly will gawp repulsive. Never knowledge. The goal of this have is not to make obvious your graphic art prowess, but to show evidence of that 'you' are skilled of a production.
You need not coating the sculpture at one short, but income your clip and colour a shrimpy bit at a incident. You will be surprised that the small bit of painting concluded occurrence will sort your chef-d'oeuvre genuinely alone. Every time you add more than a few vegetation strokes, your graphic art takes a new genre. When you have finished, or you are thrilled next to the artwork, put it parenthesis and lift a worthy form at it sometime future. Perhaps you are not extremely thrilled beside your artwork, but don't underneath approximation your own ability, for out location somewhere, in attendance will be person who would appreciate your stunning success. Beauty is in the opinion of the beholder!Post ads:
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If you construe your art will not brand it to the Louvre, don't sulk, retributory do different one. The certainty that you have started and finished something is merely a bad achievement, as in attendance are thousands of others out within who have fair wished in their consciousness and have through with nada instead! If you are not fascinated in creating an art piece, just use the self fashion to open up what you have wished to do. You can pen an article, a book, or even create by mental act something. So don't pithy coppers yourself, you are surefooted of doing large things, honourable distribute yourself 'that chance' so heaps of us denied ourselves.
Yap Tat Meng
Inventor, journalist and marketer.
More of the author's go-as-you-please thinking on artistic quality and inventing methods can be found in his


text: Sunspear Scout Wandering Priest Ghostly Scout "Vabbian Scouts are warriors that can be found in Vabbi. They often stand near Resurrection... Vabbian Scout Pages in category "Sunspear Bounty NPCs" The following 4 pages are in this category, out of 4 total. G Ghostly ScoutS Sunspear ScoutV Vabbian ScoutW Wandering Priest Retrieved from "http://guildwars.wikia.com/wiki/Category:Sunspear_Bounty_NPCs?oldid=473561" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Category: Nightfall NPCs


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Full Frontal Magic: Before the Spirit is Summoned
People have many ways to work with spirits, but most people donât pay attention to the âbeforeâ (and in some cases the âafterâ) the ritual. [Read more…]
Full Frontal Magic: Skip the Resolution, Embrace the Change
New Years is a time that many of us make resolutions to change over the next year. Statistically, we all are abysmally bad at actually succeeding at resolutions. [Read more…]
Full Frontal Magic: The Death of Modern Godforms
In modern times, we live in a society devoid of traditional myth making in relating to the natural world. In a way, the glamour, fame, and acclaim our modern stars receive seems like a modern secular replacement for these. [Read more…]
Full Frontal Magic: Five Ways to use Spirituality to Break the Holiday Stress (and Bring Happiness)
You do not need to be stressed about the holidays. No, really, you donât, but just saying that isnât going to stop it. [Read more…]
Full Frontal Magic: Reducing Holiday Hostility through Blessed Food
We tell ourselves, spending time with family should be a great time, but old wounds and scars usually remain. Letâs admit it, our family are the ones who best know how to get under our skin. We can, however, decide to change that. After all, we have magic. [Read more…]
Full Frontal Magic: Breaking the Veil and the Politics of Spirituality
A prison has boundaries. We call them walls, but a wall or fence is a boundary that one or more parties decided to empower with force and in some cases violence. âThe Veilâ has become something more like a prison. It is unclear whether or not we were the prisoners or prison guards to many magicians. [Read more…]
Full Frontal Magic: Exorcisms, Healing, and Getting Your Life Back
In a sub-series for Full Frontal Magic, I want to talk specifically in this article about clearing, banishing, and exorcism in relation to the healing process. [Read more…]
Full Frontal Magic: Extended Spellwork and Self-Compassion
So, I have been doing magic, every day for two hours for 20 days. Connecting to the same spirit in a powerful way, for a specific and large purpose. [Read more…]
Full Frontal Magic: Vision and Movement – Rising Above the Gossip
Rarely do we openly talk about power and exclusion, but we need to start having real conversations. As an occultist, I can tell you that I personally do not always feel welcome at all pagan events. [Read more…]
Full Frontal Magic: Prayer 2.01 Beta (We're All Still in Beta)
Many people pray. Sometimes multiple times in one day. âPetition magicâ and prayer are the oldest forms of magic. With a few tricks, we can make our prayers change our world more often. [Read more…]


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If you got a question, look no further.
We post the most common questions
in our FAQ section.
Please fill in the form below to receive a Free Sample of the Report.
SummaryPetrowest Corporation (Petrowest) is an oilfield consulting and services company that provides pre-drilling and post completion services and general infrastructure construction services. The company offers construction, civil works, transportation, environmental and rental services. It offers transportation services such as murtron hauling, cutbank trucking, CJM trucking and trans carrier services. The company's civil works comprise mobile gravel crushing and sour gas monitoring and supplied air services. It provides service in the acceptance and handling of hazardous waste and contaminated soils. The company serves oil and gas, oil sands, mining, logging, pulp and paper, and civil construction industries. Petrowest is headquartered in Calgary, Alberta, Canada.Petrowest Corporation Key Recent DevelopmentsMay 10,2017: Petrowest Announces First Quarter 2017 Financial Results And Corporate UpdateMay 05,2017: Petrowest Announces Waiver ExtensionApr 21,2017: Petrowest Announces Waiver ExtensionApr 13,2017: Petrowest Announces Waiver ExtensionMar 31,2017: Petrowest Announces Waiver ExtensionThis comprehensive SWOT profile of Petrowest Corporation provides you an in-depth strategic analysis of the company's businesses and operations. The profile has been compiled by GlobalData to bring to you a clear and an unbiased view of the company's key strengths and weaknesses and the potential opportunities and threats. The profile helps you formulate strategies that augment your business by enabling you to understand your partners, customers and competitors better.This company report forms part of GlobalData's 'Profile on Demand' service, covering over 50,000 of the world's leading companies. Once purchased, GlobalData's highly qualified team of company analysts will comprehensively research and author a full financial and strategic analysis of Petrowest Corporation including a detailed SWOT analysis, and deliver this direct to you in pdf format within two business days. (excluding weekends).The profile contains critical company information including*, - Business description – A detailed description of the company's operations and business divisions. - Corporate strategy – Analyst's summarization of the company's business strategy. - SWOT Analysis – A detailed analysis of the company's strengths, weakness, opportunities and threats. - Company history – Progression of key events associated with the company. - Major products and services – A list of major products, services and brands of the company. - Key competitors – A list of key competitors to the company. - Key employees – A list of the key executives of the company. - Executive biographies – A brief summary of the executives' employment history. - Key operational heads – A list of personnel heading key departments/functions. - Important locations and subsidiaries – A list and contact details of key locations and subsidiaries of the company. - Detailed financial ratios for the past five years – The latest financial ratios derived from the annual financial statements published by the company with 5 years history. - Interim ratios for the last five interim periods – The latest financial ratios derived from the quarterly/semi-annual financial statements published by the company for 5 interims history. Note*: Some sections may be missing if data is unavailable for the company.Key benefits of buying this profile include, You get detailed information about the company and its operations to identify potential customers and suppliers. - The profile analyzes the company's business structure, operations, major products and services, prospects, locations and subsidiaries, key executives and their biographies and key competitors. Understand and respond to your competitors' business structure and strategies, and capitalize on their weaknesses. Stay up to date on the major developments affecting the company. - The company's core strengths and weaknesses and areas of development or decline are analyzed and presented in the profile objectively. Recent developments in the company covered in the profile help you track important events. Equip yourself with information that enables you to sharpen your strategies and transform your operations profitably. - Opportunities that the company can explore and exploit are sized up and its growth potential assessed in the profile. Competitive and/or technological threats are highlighted. Scout for potential investments and acquisition targets, with detailed insight into the companies' strategic, financial and operational performance. - Financial ratio presented for major public companies in the profile include the revenue trends, profitability, growth, margins and returns, liquidity and leverage, financial position and efficiency ratios. Gain key insights into the company for academic or business research. - Key elements such as SWOT analysis, corporate strategy and financial ratios and charts are incorporated in the profile to assist your academic or business research needs.
Table of Contents Section 1 - About the Company Petrowest Corporation - Key Information Petrowest Corporation - Overview Petrowest Corporation - Key Employees Petrowest Corporation - Key Employee Biographies Petrowest Corporation - Key Operational Heads Petrowest Corporation - Major Products and Services Petrowest Corporation - History Petrowest Corporation - Company Statement Petrowest Corporation - Locations And Subsidiaries Head Office Other Locations & Subsidiaries Section 2 - Company Analysis Petrowest Corporation - Business Description Petrowest Corporation - Corporate Strategy Petrowest Corporation - SWOT Analysis SWOT Analysis - Overview Petrowest Corporation - Strengths Petrowest Corporation - Weaknesses Petrowest Corporation - Opportunities Petrowest Corporation - Threats Petrowest Corporation - Key Competitors Section 3 - Company Financial Performance Charts Petrowest Corporation - Financial Ratios Financial Ratios - Capital Market Ratios Financial Ratios - Annual Ratios Financial Ratios - Interim Ratios Financial Ratios - Ratio Charts Section 4 - Appendix Appendix Methodology Ratio Definitions About GlobalData Contact Us Disclaimer Note*: Some sections may be missing if data is unavailable for the company List of Tables Petrowest Corporation, Key Information Petrowest Corporation, Key Ratios Petrowest Corporation, Share Data Petrowest Corporation, Major Products and Services Petrowest Corporation, History Petrowest Corporation, Key Employees Petrowest Corporation, Key Employee Biographies Petrowest Corporation, Key Operational Heads Petrowest Corporation, Other Locations Petrowest Corporation, Subsidiaries Petrowest Corporation, Key Competitors Petrowest Corporation, SWOT Analysis Petrowest Corporation, Ratios based on current share price Petrowest Corporation, Annual Ratios Petrowest Corporation, Interim Ratios Currency Codes Capital Market Ratios Equity Ratios Profitability Ratios Cost Ratios Liquidity Ratios Leverage Ratios Efficiency Ratios List of Figures Petrowest Corporation, Performance Chart Petrowest Corporation, Ratio Charts


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The Administration for Children's Services (ACS) is an agency in New York City, that wants to ensure the safety and well-being of children.
- Detective Benson told Dr. Rohit Mehta that ACS will arrange for foster care after Melanie Cramer has been released from St. Catherine's hospital. (SVU:"Charisma")
- Marilyn Nesbit was so afraid of having her children removed that she convinced them to shoot themselves. (SVU:"Home")
External linkEdit
- ACS on the New York City Administration for Children's Services website.


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Zucchini Beef Skillet
READY IN: 30mins
Recipe by Chef Lulu13
Top Review by OddSpirit
This recipe was a hit with the fam! Since a couple of the reviews mentioned that it might need a little more flavor, I adjusted the recipe as follows:
1 tsp Tajin ( Mexican Seasoning)
14 oz can diced tomatoes with jalapeño peppers (I drained the liquid from the tomatoes into a measuring cup and then added water to the 1/2 cup mark)

I served this over rice and sprinkled some Mexican Blend Shredded Cheese on each serving.
See Discussion:9 Reviews
Ingredients Nutrition
- 1 lb ground beef
- 1 chopped onion
- 1⁄2 chopped pepper
- 1 1⁄2 teaspoons salt
- 1⁄4 teaspoon pepper
- 1 teaspoon chili powder
- 3 cups sliced zucchini
- 1 (14 ounce) can diced tomatoes
- 1⁄2 cup water
Directions See How It's Made
- Saute onion and pepper.
- Add ground beef and brown.
- Add remaining ingredients, cover, and simmer 15 minutes or until veggies are tender.


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Learning Communities are a strategic initiative at the University of Connecticut* designed to enhance the undergraduate experience of students. Over 200 faculty, staff, and student leaders representing every School and College, as well as a number of programs, volunteer to work with Learning Communities. Our communities are successful because bridges are created by bringing people across campus together to work towards addressing the needs of our students as well as engaging them broadly in the varied opportunities available to them at UConn.
Faculty Oversight Board:
The First Year Programs and Learning Communities Faculty Oversight Board is charged with setting the criteria for courses that satisfy content area and competency requirements for First Year Experience courses; reviewing and approving course proposals for UNIV 1840 and 3820 sections; developing policy for delivering the FYE program; certifying and periodically monitoring courses and instructors for quality assurance purposes; and advising the FYP & LC Office in matters related to program management.
Learning Community Steering Committee:
The purpose of the LC Steering Committee is to bring together representatives from additional key areas across campus to ensure ongoing communication and collaboration, to encourage insight and guidance to enhance our efforts, and to discuss innovative approaches to serve students in cohesive and impactful ways.
|Tracy Anderson
|Senior Marketing Associate for University Communications
|Lauren DiGrazia
|University Registrar
|Melissa Foreman
|Assistant Director of the Learning Community Program
|Hedley Freake
|Faculty Director of Nutritional Sciences LC, Professor of Nutritional Sciences
|Nathan Fuerst
|Director of Undergraduate Admissions
|Kristen Glines
|Assistant Program Coordinator of the Learning Community Program
|Jennifer Griffin
|Associate Director of Undergraduate Admissions
|Jennifer Lease Butts
|Assistant Vice Provost for Enrichment Programs, Director of the Honors Program
|Margaret Malmborg
|Manager of the Lodewick Visitors Center
|Maria D. Martinez
|CAP Director, McNair Scholars Program Director & Assistant Vice Provost of the Institute for Student Success
|Jennifer Murphy
|Program Coordinator of the Learning Community Program
|David T. Ouimette
|Executive Director of First Year Programs & Learning Communities
|Pamela Schipani
|Executive Director of Residential Life
|Logan Trimble
|Executive Director of Building Services
|Dana Wilder
|Assistant Vice Provost for Academic Affairs & Diversity
|Christine M. Wilson
|Assistant Vice President for Student Affairs, Director of Student Activities


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In Dmitry Osten's debut at Lucas Entertainment he was with two guys, Tomas Brand and Rocco Steele. He finds himself in a familiar situation, but this time around he's with Tomas Brand's partner Logan Rogue and Dylan James. It's obvious he's a greedy bottom. Dylan pounds the hell out of Dmitry's ass in this tag team fuck, which sees him later sign an exclusive contract with Lucas Entertainment. Who wouldn't after Dmitry?
See more at Lucas Entertainment


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CARROLL PLANTATION | A First Wind subsidiary will try again to build an industrial wind site on Bowers Mountain, this time proposing to erect 16 turbines instead of 27, company officials said Wednesday. The new project, company officials said, answers problems that led the Land Use Regulation Commission to …
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Discussion in 'The Lounge' started by Muddytazz, Nov 14, 2003.


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We spent three nights at this lovely bed and breakfast . Very comfortable , neat and quite. Location is perfect , just a minute away from the beach. Breakfast is rich continental with lots of great , fresh tropical fruits. The only negative is that wifi , although not committed , is not really working despite the various " tricks" tried by the owners. For the price paid , a working internet could be easily included without a real burden to the owners.
- Official Description (provided by the hotel):
- Exclusive B&B Accommodation you only dream about. An intimate couples retreat, honeymooners delight, or a place for anyone to simply getaway, relax, and unwind surrounded by the beauty of nature. 3 Stunning rooms to choose from.This stunningly luxurious two-storey villa will truly embrace, and make you feel like you never want to leave. Perfumed Frangipani trees purposely shade the entrance and welcome you as you arrive at Frangipani Bed and Breakfast. Downstairs the home is open plan living with bi-fold doors that open out onto the large outdoor entertaining area, and your own secluded heated swimming pool. Huge palm trees and tropical ferns add to the ambience and relaxation of your very own tropical setting. The top floor has 3 main bedrooms all with their own private balcony, bi-fold floor to ceiling glass doors, uninterrupted views to the inviting pool and tropical gardens below. Each room contains its own private en-suite, with a king size bed which can be converted into two large single beds. As well as having its own bar fridge with tea and coffee making facilities provided, and brand new LCD flat screen TVs. Frangipani B&B has direct access (no crossing roads) to the pristine sands of Four Mile Beach and the crystal waters of the Coral Sea only a short 100 metre walk. The perfect place to watch the sunrise over the horizon, or ride the bicycles (provided) along the sand. A Tropical Continental Breakfast is served downstairs as a buffet each morning and is all-inclusive.There is direct access to your room via an alternate outside route, so you can come and go as you please at all hours without having to go through the main house if you don't want to. Features of this B&B also include bicycles that you can use to ride along the beach, and a new undercover table tennis area. Features also include: Barbecue, Air Conditioning, All Linen Supplied, Refrigerator, TV, Clothes Dryer, Iron, Washing Machine, Hairdryer, Transport arranged, Bath and Pool towels, Brochures, Heated Swimming Pool, and Tour Bookings.Check out a recent TV review on YouTube, search: Frangipani Bed and Breakfast ... more less


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Tres Leches Cake Turned Into a Shake...But Only Until Sunday
Tres leches cake is soaked with three milks, and we can't get enough of it.
Hungry Dudes (Flickr Creative Commons)
Hopdoddy, the fast-casual burger restaurant and bar in Scottsdale has taken two things we love, the milk shake and tres leches cake, blended them together and presented heaven in a cup. If you would like a serving of your own, be sure to get there by Sunday before their drink special ends.
See also: Burger Battle: Hopdoddy vs. Paradise Valley Burger Co.
Tres leches cake is, by definition, three-milk cake. It is disputed where the cake actually originated--some say Nicaragua, some say Mexico. We say it doesn't matter because it is simply delicious. It is reported that the Néstle company would print recipes on the labels of its canned milk to promote the use of the milk, and the recipe for tres leches was one of them. Evaporated milk, condensed milk and heavy cream are combined and poured on top of a sponge cake after it has been baked.
Holes are made on top of the cake with either a fork or skewer, the milk is poured over the surface, and is left to sit for about half an hour so the cake can absorb the moisture evenly. The cake literally acts as a sponge and holds all three milks to maintain a pleasant texture without it becoming mushy. If it's mushy, then you know you've got a bad batch.
Once the cake has soaked (it's especially good when it's been cooled in the refrigerator), it is topped with a light vanilla frosting and adorned with a cherry and usually a few pieces of strawberry.
Hopdoddy's tres leches shake is a beautiful ode to the culturally rich cake.
Natalie Miranda
Now imagine all that in a cup. Hopdoddy gives a fresh take on the Latin dessert without any injustice. The shake is made of fresh baked yellow cake, homemade caramel and cajeta sauce, and macerated strawberries all blended with Hopdoddy's vanilla ice cream. It is topped with whip cream and more cajeta sauce and a few more slices of bright red strawberry. Accompanying the shake is a large boba-like straw so the cake and strawberry chunks get caught in the straw.
Before you shake your head in disapproval, has anyone ever said cookie dough chunks didn't belong in ice cream? We didn't think so. The shake we sampled was a beautiful sight. It was dense and sweet, but it definitely did not cross the line of giving us a cavity. If you're with a group, we recommend ordering your own because you will not want to share. With a shake packed with that many products, we were pleasantly surprised that it didn't make us feel heavy or stuck after downing it.
May we also recommend pairing the tres leches shake with Hopdoddy's seven-layer burger, a spin on the seven-layer burrito. It tastes more like a tostada than a burrito, which we're totally okay with. Both the burger and the shake complement one another and balance out the palette. But again, this shake is only available until Sunday, so if you want in on the action, you best act quickly.
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