text:
The study design and methodology for the ARCHER study - adolescent rural cohort study of hormones, health, education, environments and relationships
- First Online:
- Received:
- Accepted:
- Citations
- 5.8k Downloads
Adolescence is characterized by marked psychosocial, behavioural and biological changes and represents a critical life transition through which adult health and well-being are established. Substantial research confirms the role of psycho-social and environmental influences on this transition, but objective research examining the role of puberty hormones, testosterone in males and oestradiol in females (as biomarkers of puberty) on adolescent events is lacking. Neither has the tempo of puberty, the time from onset to completion of puberty within an individual been studied, nor the interaction between age of onset and tempo. This study has been designed to provide evidence on the relationship between reproductive hormones and the tempo of their rise to adult levels, and adolescent behaviour, health and wellbeing.
The ARCHER study is a multidisciplinary, prospective, longitudinal cohort study in 400 adolescents to be conducted in two centres in regional Australia in the State of New South Wales. The overall aim is to determine how changes over time in puberty hormones independently affect the study endpoints which describe universal and risk behaviours, mental health and physical status in adolescents. Recruitment will commence in school grades 5, 6 and 7 (10–12 years of age). Data collection includes participant and parent questionnaires, anthropometry, blood and urine collection and geocoding. Data analysis will include testing the reliability and validity of the chosen measures of puberty for subsequent statistical modeling to assess the impact over time of tempo and onset of puberty (and their interaction) and mean-level repeated measures analyses to explore for significant upward and downward shifts on target outcomes as a function of main effects.
The strengths of this study include enrollment starting in the earliest stages of puberty, the use of frequent urine samples in addition to annual blood samples to measure puberty hormones, and the simultaneous use of parental questionnaires.
KeywordsPuberty Hormones Adolescent Cohort studies Rural health Behaviour Wellbeing Public health Protocol Paediatrics
Adolescence is a time when interventions have the capacity to make changes in individual health trajectories [1, 2, 3]. The aim of this study is to understand the effects of longitudinal changes in puberty hormones, especially the onset and tempo of change, on adolescent health and well-being. The present paper presents the research protocol for the study, with an emphasis on the newer technologies which have made this type of study possible.
The major and rapid increases in puberty hormones mean that repeated hormone measurement is essential to appraise the relationships between biological variation in puberty hormones and the concomitant adolescent health problems and to allow exploration of the biological determinants of individual, social and physical environmental factors that are prominent in adolescence [6]. This is the first challenge in research of this nature. The onset of puberty occurs when testosterone and oestradiol begin to rise above the levels of childhood. This event occurs anywhere between the ages of 8 and 13 years [7, 8] but chronological age is an unreliable indicator of pubertal stage. The tempo, or time, to complete the pubertal increase in reproductive hormones is comparatively rapid, between 18 months and four years, which is too rapid to be characterized by annual or less frequent blood sampling. Although the impact of variable tempo of puberty on health and wellbeing has not been well studied (or reported) [9], we propose that tempo is a key variable mediating the clinical effects of dynamically changing puberty hormones on adolescent health and behaviour [10]. It is notable that hormonal events of puberty are as dramatic in scope and amplitude as more well known examples of rapid hormonal change that cause defined physical, behavioural and mental effects such as the menstrual cycle, pregnancy, castration, anabolic steroid use and the menopause [11, 12, 13].
Universal aspects of adolescent health and wellbeing which include social and emotional wellbeing, educational engagement and motivation, and sleep.
Health risk behaviours which include unintentional injury, alcohol and other drugs, sexual activity and conduct disorder.
Mental health which includes depression, anxiety and self harm.
Physical health which includes chronic illness and disability and cardiovascular risk factors – overweight, physical inactivity and tobacco use.
Universal aspects of adolescent health and wellbeing
Socially competent adolescents are more likely to do well in education and less likely to have mental health problems [14]. Learning and engagement in education in adolescence is critical to social and emotional development and well-being, but the influence of the onset of and tempo of pubertal hormone rise on motivation and engagement in education, particularly when compared with the effects of socio-economic status and mental health, is as yet unknown [15]. Sleep disturbances in adolescents are common and may affect school performance and mood. The most common adolescent sleep disorder is delayed sleep phase syndrome (5-10%) [16]. What is not known is how the onset and tempo of pubertal hormone changes relate to sleep alterations and disturbances [17].
Health risk behaviours
Unintentional injury is the most common cause of death in adolescents [18], mainly as a result of road traffic accidents [19], poisoning and drowning. Previous work has highlighted possible associations between pubertal stage as estimated by direct physical examination and physical injury incidence [20], but the onset of and the rate of the rise in pubertal hormones have yet to be studied in this context. Drug and alcohol use in adolescence increases the likelihood for reduced educational attainment, co-morbid mental health disorders, substance abuse and dependence, criminality, and psychiatric disorders in adulthood [21]. We propose that puberty onset and tempo also play an important role in these associations [22]. Sexual activity in teenagers is occurring at younger ages and teenagers are more likely to report multiple partners than in previous generations [23]. The relative contribution of changing pubertal hormone levels, specifically tempo, to sexual activity has not been confirmed and the mechanism of their influence and modifiers are completely unknown. Conduct disorders appear in pre-puberty or first emerge in puberty [24]. There are conflicting data about these disorders and their relationship to early or late maturation as measured by self report and single measurements of blood testosterone levels.
Mental health
Depression and anxiety are the most common mental health problems in young people. At any time point, up to five percent of adolescents experience depression severe enough to warrant treatment, and around 20% of adolescents will have experienced significant depressive symptoms by adulthood [25, 26]. On self reported Tanner Stages, depression occurs most commonly at Stage 3 in girls and before Stage 3 in boys. There is conflicting evidence about whether age of onset of puberty influences depression [27, 28, 29]. Higher rates of self-harm are found among adolescents in self-reported late puberty compared to early puberty [30]. The association is mediated by depressive symptoms, sexual activity and alcohol intake, and often attenuates with increasing age [31].
Physical health
Fifteen percent of adolescents have a chronic physical illness or disability [32]. If serious this may retard the onset of puberty and potentially alter tempo [33]. Overweight, physical inactivity and tobacco use, which are the top three contributors to the burden of disease in developed countries [34], all increase during adolescence [35]. Twenty percent of adolescents smoke by the age of 17 years [36]. There are no longitudinal studies on how the age of onset and rate of change or tempo of puberty hormones influence the cardiovascular risk factors of overweight, physical inactivity and tobacco use.
The ARCHER study is a multidisciplinary, three year, longitudinal cohort study, using a convenience sample. The research hypothesis of the study is that onset and/or tempo of the rise in puberty hormones play a significant role in adolescent health and wellbeing. The ARCHER study commenced recruitment in June 2011 and has enrolled 200 adolescent participants (with parent/guardian) as of March 2012.
A feasibility study for all aspects of baseline data collection was completed in 28 students in years 5&6 at a rural primary school. Sample collection, labeling, transport and storage were successful. The plasma testosterone and oestradiol levels demonstrated that the participants (except 2 -1 M, 1 F) had levels consistent with pre- or very early puberty. On-line questionnaires were revised and successfully re-piloted in August 2009 in a rural primary school with 26 students and their parents. In 2010 focus group discussions (single and mixed gender with 10–12 year olds and 13–15 year olds) were held with 58 participants. Topics included what would positively influence recruitment and retention, how peers might participate in the study and the collection of biological samples. The young people expressed strong preferences in relation to the collection process and the focus group outcomes are now published [37]. The methodology was further tested in 2010 in a funded pilot study on puberty, sleep and depression, with included the use of the Actiwatch. This is a digitally integrated recording of wrist activity which provides more detailed information on sleep wake/times [38].
Setting and study sample
The study is being conducted in Dubbo and Orange, two large towns in regional Australia in the State of New South Wales and surrounding areas. Enrollment is in school Grades 5, 6 and 7 (10–12 years of age) to ensure that both the transition into early puberty and the end of puberty are captured in adequate numbers. Each student will require a parent or guardian to also participate in the study. Lack of parental competence in English or adolescent intellectual disability are exclusion criteria. The least common primary outcome that we measure is depression, which we estimate will affect 5% of children in mid- to late-puberty [39]. We estimate that 160 boys and 160 girls at Tanner Stage 3 (the pubertal stage where clinical onset of depression is most likely) are required to detect a one standard deviation (SD) difference in testosterone nmol/l (SD = 5) [40] or oestradiol pmol/l (SD = 250) [41] levels between those with and without depression. The anticipated loss to follow up is 5% per annum in this setting. Assuming a mean age of puberty onset of 11.4 years [42], 400 subjects will ensure adequate numbers of adolescents at Tanner Stage 3 in the study, as a few younger subjects may not reach this Stage at the end of the study (age 14 years) and some older children may have already entered Stage 3 at the beginning of the study (age 12 years).
Recruitment procedures and follow up rates
Recruitment is primarily through schools, as well as through the media (targeted at parents) and through established links with local community groups. We have permission from the state Department of Education and Communities - Western Region and the Catholic Education Office – Bathurst Diocese to recruit through their schools. Data collection does not take place in the schools. Information sessions are held in the community and at consenting schools. Parents are asked to provide two additional adult contact names with the written consent, to reduce loss to follow up. Participants who agree are sent birthday cards, updates and study newsletters as reminders by their preferred mode of contact (email, letter or Short Message Service (SMS)). These practices have been shown to increase retention rates in school age children [43]. The young people requested 'get togethers' in the focus groups to celebrate their involvement in the study and these will be held annually.
Data collection
Adolescents will complete questionnaires at baseline and annually for the following three years. We will use a computerized on-line questionnaire with branched algorithmic structure, to enhance confidentiality and accuracy of responses and to reduce exposure to sensitive questions (particularly related to sexual activity). This has been created and trialed. The total number of questions for adolescents is 256. These are completed in approximately one hour (shorter for the older participants and closer to 75 minutes for younger participants). Adolescents complete the questionnaire under supervision of research staff. Questionnaires will not be performed in the fasted state and, as with all other data and biological sample collection, are done outside school hours. Physical examination occurs at baseline and annually for three years. Blood is collected at baseline and annually for three years, in the fasting state. A first morning urine sample is collected at baseline and every three months for three years. A single indicator question providing information on mood fluctuation is sent to all participants with access to mobiles phones every 3 months and functions as a reminder to complete urine collection.
A parent or guardian completes a questionnaire at baseline and annually for three years, and in the same month as their child. The questionnaires are available online or as hard copy and contain approximately 180 questions. This questionnaire reduces reporter burden on adolescents for demographic data, as well as providing other relevant family and environmental data.
Ethical approval has been granted for the pilot questionnaires, anthropometry, biological sample collection (HREC 10612), the pilot SMS and sleep studies (HREC 12502) and for the full study described in this protocol (HREC 13094) from the Human Research Ethics Committee, University of Sydney.
Questionnaires - adolescent
The Child Behaviour Check List (CBCL) in the version validated for ages 11–18 years as the Youth Self Report (YSR) [44] is the main questionnaire measurement instrument. It contains 20 social competence items that measure participation in hobbies, games, sports, jobs, chores, friendship, and activities and 8 sub-scales, measuring internalizing and externalizing behaviour. In addition the subscales provide data on social competence, learning and engagement in education, sleep, unintentional injury, drug and alcohol use, conduct disorders, disruptive behaviour disorders, depression and anxiety, and self harm. The YSR also identifies the presence of physical illness and disability.
- a)
Selected measures of self competency taken from the Raine cohort [45], including Cowen's Self Efficacy [46] and Adolescent Self Perception Profile [47].
- b)
12 selected items from Motivation and Engagement; Enjoyment of School, Academic Buoyancy and Class Participation scales [48, 49]. These results can be linked to the Australian National Assessment Program Literacy and Numeracy scores [50].
- c)
A questionnaire is used to document sleep/wake patterns, and sleep disorders in the adolescent's natural sleeping environment [51]. In addition, a convenience subset of adolescents will use the Actiwatch home monitor system annually.
- d)
Direct questions on unintentional injury type in the preceding 12 months provided by RI, selected questions from The Australian School Students Drug & Alcohol Survey [52], branched age appropriate sexuality questions on romantic relationships, sexual feelings, history of STI and pregnancy [23] and the 40 item validated Australian self-reported delinquency scale by Mak [53] in those adolescents who score highly on the YSR subscale for externalizing problems.
- e)
The Short Moods and Feeling Questionnaire (13 item) in all subjects [54]. The short form has been validated as a self-reported unidimensional measure of symptom severity of childhood depression in community samples.
- f)
The 16 item Deliberate Self Harm inventory [55] for those who respond with a 1 or 2 for YSR item 18 or 91 (relating to self-harm or suicide).
- g)
Selected questions from Health Behaviors in School-aged Children for physical inactivity, nutrition and tobacco [56].
- h)
One SMS question which is a linear analogue self-assessment scale question on mood providing information on mood fluctuation [57].
- i)
Tanner Stage of puberty by self report using standardized line drawings which allow determination of accuracy of this method of pubertal staging, which is the main method used in epidemiological and non-clinical studies.
Questionnaires – parent/guardian
- a)
Demographic data for family and adolescent.
- b)
Child Behavior Checklist (CBCL) validated questionnaire for parents of children aged 6–18 years to corroborate the adolescent's YSR [58].
- c)
The validated Macmaster's Family Assessment Device [59] to obtain information on family and local environmental factors, which are potential confounders.
After the final 3-year questionnaire all adolescents will be asked whether they believed that the speed of their puberty was faster, the same as or slower than their age peers and whether the onset of their puberty was earlier, the same as or later compared to their age peers. Their parent/guardian will be asked the same questions in relation to their child.
Physical examination – adolescents only
Weight and body composition is measured in light clothing using Tanita TBF-300 Pro Body Composition Analyzer [60]. Height, and foot length as an indicator of growth stage [61] are measured on a portable stadiometer (to 0.1 cm) and with a metal ruler (to 0.5 cm) respectively, and waist [62] with a tape (to 0.1 cm) using standard techniques. Body Mass Index, as a measure of overweight (kg/m2) and waist circumference are expressed as individual z-scores based upon age and sex related reference charts [63]. Blood pressure (BP) and pulse rate are measured using an automated BP monitor, under standardised conditions.
Laboratory – adolescents only
Fasting bloods are collected using local anaesthetic cream and separated serum and spot urine samples frozen at −80°C, as well as buffy coat in one sample. Total blood draw is approximately 30 ml. Menstrual cycle stage will be recorded in post-menarchal females, with the perimenstrual week avoided.
Testosterone and oestradiol will be measured using AP5000 LC Tandem MS in the Andrology laboratory, ANZAC Research Institute [64] (DHEA, DHT and oestrone will also be measured). There will be adequate blood collected to measure other potential biological variables of interest, which will form the basis of future studies but which are not integral to this study. These variables include LH, FSH, SHBG and IGF-1, inhibin, anti-Mullerian hormone, ACTH, cortisol, growth hormone, prolactin, oxytocin, TSH, thyroxine, triiodothyronine and Vitamin D (all of which are hormones relevant to puberty) [4], full blood count, ferritin, glucose, liver function, urea, electrolytes, full lipid profile, creatinine, and insulin, fatty acid profile, leptin, adiponectin, resistin, TNF alpha, CRP and Interleukin 6 (as indicators of cardiovascular risk and also to derive eGFR) [65]. There is the potential to be able to study genes relevant to puberty and sex steroid action; KiSS-1, KAL1, FGFR1, GnRHR, GRPR-54, TAC3, neurokininB, androgen and oestrogen receptor, steroidogenic enzymes such as CYP, StAR, P450scc, P450 (17alpha) and 17beta-HSD [66], and genes relevant to body composition and insulin resistance, such as leptin gene and product, MC4R, FTO, IL-6, and UCP-2 [67].
A first morning, fasting urine sample will be collected at home. Urinary testosterone and oestradiol will be measured, also using AP5000 LC Tandem MS. Urinary hormones, although less well standardized than blood, are essential to define hormone trajectories which can never be accomplished by a single annual sample. Sperm (indicating spermarche) will be measured in male urine samples [68]. There will be adequate urine to measure creatinine and microalbumin, but these measures are not integral to the current study.
Residential address will be geocoded [69] to obtain additional information such as neighbourhood socioeconomic status, access to services and amenities and other environmental exposures, which may be study confounders for which adjustment will be required.
Statistical analysis
- 1)
The first component is testing the reliability and validity of measures under focus. These analyses will centre on: (a) descriptive, reliability and item functioning; (b) factor analysis to test factor structure and validity of measures; (c) ANOVAs for preliminary tests of main and interaction effects of background socio-demographics; and (d) tests of (in)variance in factor structure to ensure congruence in measurement properties across sub-groups to justify pooling sample data for subsequent modeling throughout the project [70].
- 2)
The second component is a correlational one and assesses the impact of tempo and onset of puberty over time. Specifically, for example, by assessing in the one analytic model (eg. in linear regression models for continuous variables such as YSR scores for sensation seeking and in logistic regression models for dichotomous outcomes such as depression or sexual debut) the effects of Time 1 onset and tempo of puberty on Time 2 outcomes after controlling for Time 1 outcomes, it is possible to get a sense of the relative salience of the onset, and tempo of puberty in one time period over factors in a following time period [71]. Also in these longitudinal analyses, key socio-demographic (and other) factors such as gender, school grade and socioeconomic factors can be included to get a further sense of puberty by controlling for other potential influences. The three monthly urine samples for the biological markers of puberty can be used to regress time on time measures, with tempo being defined by the residuals. Thus the larger and the more positive a residual over time, the more rapid the tempo of change.
- 3)
The third component is based on mean-level differences (e.g. repeated measures) and explores for significant upward and downward shifts in means on target outcomes as a function of main effects (e.g. early and late onset; rapid and slow tempo) and interactions (e.g. early onset/rapid tempo; late onset/rapid tempo; early onset/slow tempo and late onset/slow tempo) of puberty effects that also control for key socio-demographic (and other) factors as covariates [72]. Taken together, these analyses (and adaptations of them) allow for integrative tests of the substantive and methodological issues at hand.
Analyses will be conducted using SAS, Stata and WinBUGS (for repeated measures analyses).
This study aims to extend previous puberty research which has sought to consider the relationship between the biological events of puberty and the complex, longer state of adolescence and its associated health issues. As a longitudinal study it commences at a younger age in order to capture the transition into puberty, as defined by the first elevations of testosterone and oestradiol in blood and urine. Thus puberty is defined using biological markers, which are of fundamental importance to the project. Previous studies have relied on self report of pubertal stage, which is a lagging and insensitive measure, that correlates only weakly with measured puberty hormones [5]. This will be the first study to focus on the biological tempo of puberty and its impact on adolescent health and wellbeing, with frequent biological sampling and the introduction of new, ultrasensitive state-of-the-art, mass spectrometric steroid assays. Previous studies have used immunoassay with unextracted serum, which has proven analytically inaccurate and unreliable (although faster) and which further places in doubt previously described relationships between the clinical features of puberty and its hormonal determinants.
The utility of this new knowledge, by the translation of hormone data into real life, is to better direct interventions at a time when developmental trajectories remain plastic and capable of alteration and without the need for biological sample collection. It can be done because 'puberty phenotypes' such as early or late onset (out of step with peers) or rapid tempo (rapid physical change) and which deviate most from average age of onset/average tempo (similar to the majority) are already recognizable using simple observation by clinicians, parents, educators and adolescents. What is missing is an understanding of the direction and magnitude of influence of intrinsic tempo and timing of puberty on adolescent behaviour, wellbeing and health and how hormonal changes interact with external factors. The indirect, non-biological evidence is that the magnitude of intrinsic hormonal influence is significant.
There is no suggestion that altering the onset or tempo of puberty is a realistic intervention (despite its feasibility using modern steroidal or gonadotrophin releasing hormone analogue therapy [73, 74]). It is however of great interest to determine whether the dynamic hormonal changes of puberty trigger behavioural or physical problems. If puberty hormones do have an effect, it would be possible to target established, evidence-based directed interventions to at-risk adolescents, presumably those whose puberty patterns are dissimilar to the majority. These could include evidence-based interventions in sleep hygiene, unintentional injury, mental health, and cardiovascular risk. In schools, where year levels are defined by age, rather than pubertal stage, information will be provided to better assist school personnel to identify and deal with the wide developmental range in any given year group. Adolescents, their parents and families will benefit from understanding how hormones influence adolescent behaviours. The community will benefit if knowledge gained from this study is used to improve adolescents' health and wellbeing.
Authors' information
KS (MBBS PhD FRACP) holds the Medical Foundation Chair in Adolescent Medicine at the University of Sydney Australia and is an adolescent endocrinologist. PH (BMedSc MBChB PhD FRANZCP) is Conjoint Professor of Child & Adolescent Psychiatry, Discipline of Psychiatry, Sydney Medical School, University of Sydney and Director, Infant Child & Adolescent Mental Health Services Sydney South West Area Health Service. RC (MB BS MPH PhD) is Professor of Epidemiology Sydney School of Public Health, University of Sydney. SRS (MBBS PhD FRACP) is a clinical academic and Associate Professor in the Discipline of Paediatrics and Child Health, University of Sydney and Adolescent Physician at the Children's Hospital Westmead, Sydney Australia. RI (MPH PhD) is Director of the Injury Division at the George Institute for Global Health and Professor in the Sydney School of Public Health, University of Sydney. RB (MBBS (Hons) MSc MD FRACP FRCPCH) is Head, Clinical Research, The National Centre for Immunisation Research and Surveillance. GF (MBBS MD FRACP) is Director of Diabetes and Endocrinology at the RNSH Sydney, Chair of the Diabetes Network of NSCCAHS and Clinical Professor of Medicine at the University of Sydney. DH (MBBS PhD FRACP) is Professor of Reproductive Endocrinology & Andrology. AM (BA(Hons) MEd(Hons) PhD) is Professorial Research Fellow and Australian Research Council Future Fellow Faculty of Education and Social Work, University of Sydney. GM (PhD) is Associate Professor and Deputy Director of the Northern Rivers University Department of Rural Health and an Environmental Epidemiologist. JS is a Child and Adolescent Psychiatrist at Thomas Walker Hospital (Rivendell) Child, Adolescent & Family Mental Health Services and a Clinical Senior Lecturer, Discipline of Psychiatry, Sydney Medical School. AB (MBBS MPH PhD FAFPHM) is Professor, School of Public Health, University of Sydney. MR (PhD) is a Senior Lecturer, Social Work & Policy Studies at the University of Sydney Australia and is sociologist who research includes the experiences of rural young people. DLB (MBBS FRACP FSAHM), an adolescent health physician, is Clinical Professor of Adolescent Medicine at the University of Sydney, senior staff specialist with the Department of Adolescent Medicine and Head of the NSW Centre for the Advancement of Adolescent Health, The Children's Hospital at Westmead. CMC (PhD) is a sleep scientist in the Faculty of Health Sciences, University of Sydney. ML (PhD) is an informatician in the Faculty of Health Sciences, University of Sydney. PK (PhD) is a Senior Lecturer (Biostatistics) in the School of Public Health at the University of Sydney. NB (BMed, MPHTM, RACGP) is a Professor of Indigenous Health & Education. University of Wollongong. KP (BHSc) is a registered nurse, the project manager of the ARCHER study and co-ordinated the pilot and feasibility studies. CH (MBBS FFPH) is a Senior lecturer in Rural Health at the School of Rural Health, University of Sydney and a public health physician.
The ARCHER study is supported by the Australian National Health and Medical Research Council (NHMRC) Project Grant #1003312.
The authors gratefully acknowledge the Sydney Medical School's Medical Foundation Grant which supported the initial feasibility studies and the Dean of the Sydney Medical School, Professor Bruce Robinson, for his fundamental contributions to the commencement of this study.
An Australian Rotary Health Research Foundation supported the sleep, puberty and depression study which was the final feasibility study.
In addition the authors thank the school children from Dubbo and Orange and their parents who contributed to pilot, feasibility and focus group studies.
Supplementary material
Copyright information
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
401 91 666 (Sat-Thu : 7AM to 5PM) 600 54 00 48 (Sat-Thu : 8AM to 6PM) 22052622 (Sat-Thu : 9AM to 7PM) 22034034 (Sat-Thu : 8AM to 6PM) (00973) 17558320 (Sat-Thu : 9AM to 7PM) 920022330 (Sat-Thu : 9AM to 7PM)
WiiU MarioKart 8 Console + 1 Assorted Game :- Every Wii U console comes packed with an array of applications to enjoy the day you bring your system home, after a quick system update. Interact with other Wii U players online, make video calls from your TV, download full games from the comfort of your couch, and much more. The Wii U™ GamePad controller removes the traditional barriers between you, your games, and your TV by creating a second window into the video game world. It incorporates a 6.2-...
Only GCC cards accepted.
While every care has been taken to ensure the product information represented is correct, Luluwebstore.com cannot guarantee the content displayed in terms of ingredients etc. is correct at all times. Products are constantly being reformulated so ingredients, nutrition content, dietary and allergens may change. Luluwebstore.com recommends you to always read the product label and not rely solely on the information provided on the website.If you have any queries, please contact customer service at firstname.lastname@example.com

subset: commoncrawl


text:
Choose Between Two Options
- $39 for a European facial with an aromatherapy steam and one-day spa pass ($102 value)
- $99 for a European facial with an aromatherapy steam, vanilla-chai mud wrap, and one-day spa pass ($230 value)

The spa pass includes access to the relaxation and meditation area, showers, and all bathroom amenities. Pass holders also receive private lockers for the day, as well as name-brand snacks and beverages, professional hairstyling tools and products, and towel and robe service.

The Seven Club Health & Wellness Spa
Physical. Social. Intellectual. Recreational. Individual. Financial. Vocational. These are the seven elements of The Seven Club Health & Wellness Spa, a health and wellness spa dedicated to balanced living. The staff, which includes aestheticians, massage therapists, a nutritionist, and a nail technician, helps its clients achieve this balance through services that address these areas, such as massage, fitness training, and life coaching.


text:
What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
No, we do not limit your reports to my knowledge so you could create several reports if you wish.
You can see here in our pricing plans our currently listed feature abilities which are limited per usage of each plan level.


text:
deborahdeydesigns Portfolio
I'm a digital and mixed media artist , based in Scotland. Just click on the designs below to see all the items they are available on. Find me on Facebook at http://www.facebook.com/DeborahDeyDesigns or Twitter @ddeydesigns and Instagram @ddeydesigns for updates of new designs
Showing 9 out of 9 Designs
Page 1 of 1
- 1


text:
McCall's Sewing Pattern #7948 Baby's Rompers Or Panties & Blue Transfer ©1982 "Romper A with shoulder straps and panties. B, C, D, and E have elastic in back waistline and leg casings; fronts are fastened with buttons or snap fasteners. Romper has front patch pocket. Panties B have back patch pockets. C have ruffling trim; D and E have back applilques with optional embroidery. Blue transfer is included."
Links to reviews/blog posts Edit
Sources/Vendors Edit
Gallery Edit
[insert your photos of this pattern made up]
Wishlist Edit
[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


text:
Hispanic & Latino
Students of Hispanic & Latino studies need not worry about paying for over-priced textbooks anymore – renting textbooks is an option! Hispanic & Latino textbooks – for example Parrot in the Oven: mi vida by [Victor Martinez], and Burro Genius: A Memoir (Spanish Edition) by [Victor Villasenor] – are often some of the most frequently updated books by Publishing companies. The field of Hispanic & Latino is constantly changing, and new editions can come yearly and at a huge cost to students who continually buy new books. So why buy when you can rent cheap textbooks? There are plenty of Hispanic & Latino books to rent – BookRenter has of them all!
Used book sales can be a cheap option as well, but often can be more expensive than textbook rentals. However, there are very few return policies with used books, and especially when taking Hispanic & Latino classes, buying a used book can be dangerous and costly.
List Price:$19.99
List Price:$24.95
RentList Price:$14.99
List Price:$14.99
Men May Come and Men May Go ... But I've Still Got My Little Pink Raincoat: Life and Love In and Out of My Wardrobe (Spanish Edition)List Price:$19.95
List Price:$14.95
List Price:$13.99
List Price:$17.99
Side by Side/Lado a Lado: The Story of Dolores Huerta and Cesar Chavez/La Historia de Dolores Huerta y Cesar ChavezList Price:$16.99
RentList Price:$17.99


text:
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Weiss Richard L Phd is a Psychologist office located in Flint, MI. A psychologist focuses on the evaluation, prevention, diagnosis, and treatment of mental, emotional and behavioral health issues. A clinical psychologist uses psychotherapy and other counseling skills to improve emotional and mental health.
Please call Weiss Richard L Phd at (810) 732-1100 to schedule an appointment in Flint,...
Be the first MLive.com user to add photos or videos of Weiss Richard L Ph.D.
Weiss Richard L Ph.D. is located at G3237 Beecher Rd, Flint, MI. This business specializes in Mental Health.
Weiss Richard L Phd is a Psychologist facility at G3237 Beecher Road in Flint, MI.


text:
Organisation of iron ore exporting countries (OIOEC)
Australia, Brazil and India completely dominate the export of iron ore in seaborne trade. In a market of about 750 million tonnes, Australia have about 40% of market share each and India has about 13%. You might think that these countries would cooperate to capture the surplus from rising iron ore prices and volumes.
India has an export tax or 15%. Brazil was considering an export tax earlier this year, but as far as I know they have not imposed one yet. Instead of the failed RSPT, why didn't the Rudd Government just impose an export tax and at the same time collude with Brazil and India to have them impose a similar tax. And then increase or decrease export taxes in unison to achieve the optimal extraction of rents from the market.
On current expansion plans Australia will be exporting about 700 million tonnes of iron ore by 2018. The spot price of iron is about $100 per tonne (having fallen from $180 earlier this year) and the average total cost of extraction is about $35 per tonne. A $20 per tonne tax would raise over $10 billion per year of extra taxes.
With the cooperation of Brazil and India, a much, much higher tax might be sustainable. It depends on the long term price elasticity of iron ore, of course. I don't have an estimate of elasticity, but I suspect the market is inelastic because of the shortage of high quality iron ore outside of Australia, Brazil and India.
If the three countries formed an Organisation of Iron Ore Exporting Countries (OIOEC) it would initially be met with fury from iron ore importers, especially China, but eventually it would be accepted, just as OPEC is accepted. The three countries could have a clandestine agreement, but I am not sure that could survive the open political process in Australia. Better to have an explicit, open agreement of collusion between India, Brazil and Australia. OIOEC would have to be structured in such a way that it did not run afoul of our WTO membership. That just means it would have to be a loose understanding between the countries rather than a formal agreement, but that could be arranged.
An export tax would reduce overall investment and production in iron ore in Australia. But, that is what you want as a monopolist; to restrict output to drive up the price. Since the economy is capacity constrained, deadweight losses on the Australian side would be moderate.
It seems to me that the RSPT was ridiculously convoluted. The new agreement will raise much less tax because of the market value provision for calculating a reasonable on assets. It is better to keep it simple and take a whole market approach to rent extraction by colluding with the other producers. If we don't do that we will be leaving of a lot of money on the table over the next 30 years. Let's say that global trade averages a 1.5 billion tonnes per year for 30 years and rent extraction is $45 per tonne with effective collusion between Brazil, India and Australia. There might $2 trillion, to be divided between those countries. That is the big prize that we should go after.
4 Responses to "Organisation of iron ore exporting countries (OIOEC)"
Great idea (as long as the supply iron ore is inelastic). But for libs in opposition (as opposed to in govt.) i could also see them supporting this.
*demand for iron ore
"deadweight losses on the Australian side would be moderate."
But creating deadweight losses in China et al. is okay, is it?
I'm tickled by the insight, Sam, but I have trouble supporting the extraction of monopoly rents just because we'd be the ones getting them.
Please don't give them any ideas. The welfare of people outside Australia matters too remember.


text:
Meet food bloggers and digital influencers at the non-offical Sweetup meeting during the ISM. Show us your "haul" and bring the best sweets and snacks innovations you found at ISM and share them with us in a sweet and salty dinner session at the legendary Hallmackenreuther after the trade fair. Brand marketers and Journalist are very welcome, too.
Hashtags: #sweetup #ism2015
Please RSVP here: http://www.sweetup.de/


text:
Sermon Illustrations
Sermon Illustrations > Salvation > Possessive Pronouns
Resource, July/August, 1990
Resource, July/August, 1990
"The life of Christianity consists of possessive pronouns" says Martin Luther. It is one thing to say, "Christ is a Saviour"; it is quite another thing to say, "He is my Saviour and my Lord." The devil can say the first; the true Christian alone can say the second.


text: Hi all. I just have a quick question about the set up of the USB Wi-Fi Connector. I don't have one but if I can do what i'm hoping I can do then I will be getting one. I have a wireless network at home but where the wireless router is situated in the house gives me a weak signal in my room. I can't move the wireless router (other people in the house using the wireless network = whingers....) so what I have done for my laptop computer (which is in the same room as my Wii) is run an ethernet cable under the house which connects my laptop to the broadband network. What I have read about the USB Connector is that it can be plugged into a broadband connected PC and then creates a wireless network that the Wii can access. My question (before I buy a Wi-Fi connector) is this; Can I plug the Wi-Fi connector into my laptop to create another wireless network that my Wii can access? The laptop isn't the host PC for the broadband network, its just connected to it. Does this make a difference to the Wi-Fi connector? Any help or insights on this issue will be greatly appreciated.


text:
Cat Canvas
Silverleaf Games
- December 18, 2012
( 41)
Chase a mouse, paint a painting!
This app is like paint or photoshop but for cats.
All the screenshots were created by real cats.
Keywords: cat, paint, canvas, paint for cats, photoshop, painting
This app is like paint or photoshop but for cats.
All the screenshots were created by real cats.
Keywords: cat, paint, canvas, paint for cats, photoshop, painting
Doesn't work on le pan ii Wouldn't load at all on honeycomb. Loads to menu screen on ICS but nothing happens, no response from app. Back button does not work, but all other tablet buttons function normally. Love a similar app on iPad, would love to use this one on my Le Pan II tablet. Hope to change my review soon!
Love It I wish it was easier to find in the App Store but other than that I love it! My friend has the paint for cats on her iPad and that is how I found out about this type of app but could not find anything for the life of me for Android until I searched on the internet don't know if you can change some search parameters but you might want to but love love love the app woohoo
My cat uninterested. I don't like that it does predetermined paw shapes and splotches. If the cat touches with its nose, it should leave a nose print; if she slashes across the screen it should leave a slash. The "artwork" created is not really the cat's.
So sad I loved this game a year or so ago. I had my past cat make tons of paintings. I just recently re-download the game for my new baby and the app refuses to open. I have tried it multiple times and different days. I hope they will fix it. I will put 5 stars if they do
Want a refund! This thing hasn't worked since I purchased it! Very disappointed! How do I get a refund? I am very annoyed. I have a cat who actively likes to play on my tablet.
I used to love this app when it worked! I got great images on my nexus 7 but when I upgraded to my nexus 9 the app wouldn't even open and this issue has not been addressed in over a year. Very disappointing for a paid app.
What's New
Fixed a bug where sometimes the app would ignore the palette you chose
♪ app that can play by touching the character of pushing "motif of ~ Canvas ~ Sepia" popular game


text:
Issue Position: Make Health Care More Accessible
Our country is on the leading edge of health care technology, medicines, and equipment, and I applaud the physicians, researchers, and other health care providers who make our quality of care so high. Such an advanced system, however, does not come free, so I would work in Congress in favor of policies that would encourage more people to purchase health insurance and to make that insurance more accessible. I also would support the tremendous private-public partnerships that have emerged through the community health clinics in our area, which provide high-quality care at a reasonable cost to keep people working and children in school.
Source: http://www.nickjordan.com/inner.asp?z=3


text:
This property is no longer available.Search for Available Property.
6.02 acres in Hood County, Texas
Perfect space to build your dream home or business. 6.020 acres with lots of trees close to town.
Both Residential and Light Commercial. No Restrictions .
From Granbury Square, go north on Houston, left on FM 4 after RR tracks, about 5 miles turn right on Tin Top Hwy, just pass the corner of Tin Top and Roberson, on the right side.
Tax Data (Show Tax Data)
Tax data is not available for this listing.
Contact the Seller for more information.
Other Land for Sale in Hood County
- Properties for Sale in Nearby Counties
- Erath County Land for Sale
- Johnson County Land for Sale
- Palo Pinto County Land for Sale
- Parker County Land for Sale
- Somervell County Land for Sale
NOTE: The information contained herein is provided as general information only and has been obtained from sources deemed reliable. It is provided without any guaranty, warranty or representation, expressed or implied, made by Lands of America, or any related entity, as to the accuracy or completeness of the information. The information is presented subject to errors, omissions, change of price or conditions, prior sale or withdrawal without notice. Prospective purchasers should make their own investigations, projections and conclusions concerning the information.


text:
Anyone hear of expansion/merger plans for ECHL, CHL, SPHL FOR 2013-14?
View Single Post
Sports Enthusiast
Not Here To Be Liked
Join Date: Sep 2010
Location: Middle of nowhere
Posts: 18,549
vCash: 500
Originally Posted by
It was sad that Johnstown left the ECHL, but they had an outside owner and he put very little $$$ into the team. Their last season was a joke.
But now they have a team in the NAHL, the Tomahawks. Very good first season, made the playoffs. Averaged over 2,500 look to see that increase next season. Season tickets should pass the 1,000 mark.
Difference - group of owners (local - Pittsburgh area), brought back a few of the ex-Chiefs to run the team as GM, coach and asst. coach. Made an impact in the community - their presence was known.
I would not want them to return to a higher class league as would most people in Johnstown. For many of the small cities juniors is the way to go.
Would not be surprised to see Wheeling & Elmira drop down in a few years.
I look at it as Juniors have improved and the ECHL to a degree has declined. It's not the league it started out as. Maybe they intended it to be a developmental league but it did not always play out as it does now. Now the majority of the players in the league are of organizational contract, etc. Playing for the team is secondary it's more so your career. People from a big place wouldn't get this but in a smaller city, the type in which this league was started in player continuity is important, you just don't have that anymore
Sports Enthusiast
View Public Profile
Sports Enthusiast's albums
Find More Posts by Sports Enthusiast


text:
The Magna Carta, a document signed by the English monarch King John on June 15, 1215 at Runnymede, near London, represents a point in history where the destiny of humanity shifted course. The document, sealed by the king under the threat of rebellion, outlined the framework within which the English monarchy would be permitted to govern and referred directly to private property rights, freedom from arbitrary arrest and representative government. As such it operated as a check on absolutism and paved the path for both the English Constitution which would emerge almost five centuries later and the U.S. Constitution which followed in 1788. Without the Magna Carta, the freedoms and liberty we enjoy today would not have been possible.
Yet today the Magna Carta is largely relegated to irrelevance by revisionist historians and academics who disregard the arduous journey undertaken by our ancestors over the course of 800 years to secure our individual rights and liberties.
This international conference, involving world leaders from five continents and experts drawn from throughout the West, will seek to illuminate the significance of this document for world history, the dangers of failing to recognize its relevance, the centrality of the Anglosphere in the spread of human liberty and will conclude with an examination of how we can stop historical revisionism from destroying our connection to the past.


text:
Users Online Now:
Who's On?
Visitors Today:
Pageviews Today:
Threads Today:
Posts Today:
Donate To GLP
Adv. Search
Back to Forum
Back to Thread
Message Subject
*** The Walking Dead Season 3 Official Thread! ***
Poster Handle
Anonymous Coward
Post Content
SENOIA, Ga -- It's pretty clear that zombies like the state of Georgia. If you watch "The Walking Dead" you have seen several Georgia locations where the popular television series was shot.
Now it appears that season three of the AMC hit will be shot here too. One Georgia City with a Hollywood-like reputation will benefit most. The city of Senoia has been told by the show's location manager that most of the upcoming season will be shot there.
The city's Main Street will be the main set for when the show starts shooting on May 31, 2012. Cast and crew could be in Senoia until November. "We've gotten used to how to direct traffic, how to deal with businesses," the city's Director of Downtown Development Scott Tigchelaar said.
Imagine downtown Senoia as the center of a walled city, a sanctuary from a zombie apocalypse. That's the only hint city officials have been given about what will take place in Senoia.
If you walk down Main Street and look down at the sidewalk your steps are marked by plaques of some of the dozen or so movie and television projects that have been filmed here.
Some of the more popular films are Driving Miss Daisy, Fried Green Tomatoes, Andersonville, Sweet Home Alabama, Broken Bridges and Footloose.
Tigchelaar said Senoia's commitment to these projects has helped it get through a tough economy, unlike other Georgia cities and towns. "Probably the last five or six years have been the toughest economy any of us have ever seen," he said. "We've gone from six businesses on Main Street to 45 businesses on Main Street."
Gail Downs owns Gail's Antiques. Her store is littered with mementos of the stars who have visited her shop. She said the Hollywood invasion of Senoia has been good for business. "Especially in the antiques business because we have a lot of people that come in when they're filming the movies and they're looking for props," she said.
She's looking forward to the summer shoot. "It's going to be huge and bring lots and lots of people," she said.
Parts of the first two seasons of "The Walking Dead" were shot in Senoia. Mike Riley, the shows location manager told city council members, "Senoia will be a major set for next season."
Please verify you're human:
Reason for copyright violation:
Disclaimer / Copyright Info
Privacy Policy
Terms Of Use
with questions or comments about this site.
"Godlike Productions" & "GLP" are registered trademarks of Zero Point Ltd. Godlike™
Website Design Copyright © 1999 - 2017 Godlikeproductions.com
Page generated in 0.005s (5 queries)


text:
Wintrust Financial Technical Analysis (NASDAQ:WTFC)
Technical analysis is the study of technical chart patterns and does not rely on the financials of a company. When a chart pattern that can predict future Wintrust Financial stock price movements is formed, the WTFC stock chart can become a key tool for a technical analyst.
View technical indicators like moving averages (SMA and EMA), and bollinger bands for Wintrust Financial. Technical analysis uses an approach for Wintrust Financial stock analysis that does not care for the fair "value" of a company but uses price and volume data only.
Wintrust Financial Moving Average:
Moving averages show the WTFC stock price trend. The two most popular types of moving averages are the Simple Moving Average (SMA) and the Exponential Moving Average (EMA). The longer the duration of the moving average, the higher the lag. For example, 200 day moving averages for Wintrust Financial are mostly signals of long term trends and will help long term traders.
Wintrust Financial Bollinger Bands:
Bollinger Bands were developed by the famous technical trader John Bollinger and are a measure of the volatility of a stock like the WTFC stock. Wintrust Financial bollinger bands show that the stock price is $76.95, upper band is 47.11, lower band is 44.31, and the average is 45.71.
Wintrust Financial Moving Average Convergence Divergence or MACD:
The moving average convergence divergence or MACD is a technical indicator which helps gauge the stock price trend, as the indicator is useful in understanding the strength, direction and momentum of the stock price. The Wintrust Financial MACD line is above the signal line.
Wintrust Financial Relative Strength Index:
The RSI is a valuable tool to determine overbought / oversold stocks and measures the recent performance of a stock in relation to its own stock price history. The relative strength index of WTFC stock is 42.62. .


text:
Mulberry Paper Works was the largest single source of work in the Nikesake region, as it produced paper for the entirety of the Phoenix lands. The majority of the raw materials came from mulberry groves around Nikesake. Families that had run the paper works for generations owned special workshops which were used for making high-quality paper for use by high officials. [1]
- ↑ Strongholds of the Empire, p. 70
|This Phoenix Clan related article is a stub. That means that it has been started, but is incomplete. You can help by adding to the information here.


text:
You have no items in your shopping cart.
Our Puma PJ6 Pricing Gun has a single line containing 8 digits pricing up to £999.99. It has a wide opening for easy label loading and one touch easy load ink roller. Includes the Pound (£), Euro (€) and Dollar ($) symbols.
The Labels are available in peelable and permanent.
Pack includes: Puma PJ6 Pricing Gun with ink roller, replacement ink roller and instructions.
Labels are sold separately in boxes of 18,000
UK mainland - We offer a next day delivery service(excluding Saturday, Sunday and Bank Holidays) between 9am and 5pm. We endeavour to dispatch goods on a next day delivery service as long as the order reaches our office before 1pm.AM and Saturday deliveries are available at additional charges. Please feel free to inquire. Delivery charges are calculated by weight and are applicable at the checkout once your order is complete.
Remote delivery charges –Deliveries to Ireland, Isle of Man, Channel Isles, Isle of Sicily and the Scottish Isles incur additional surcharges. Please inquire if you are placing an order from these areas.
Returns – There is a handling charge of 15% on all returned goods.
Damages and shortages –All damages or shortages must be notified within 2 days of receiving your orders.
Redelivery charges –All orders need to be signed for and parcels will only be left at alternative addresses if the customer has supplied us with the information. Please advise us the days you are not there to accept deliveries or there will be redelivery charges applied which is 50% in addition to the standard delivery charge paid.We at Trade Lines endeavour to dispatch your orders as quickly and efficiently as possible. However, we cannot be held responsible for late deliveries by the carriers.Thank you for shopping with us.
Counters -Most of our counters are stated as free delivery. For some counters, where it does not state free delivery, please inquire for the relevant delivery charges as per your location. We will quote you our best prices possible. Slatboards – All orders for slatboards above the quantity of 4 are sent via Pallet. It is a cheaper and more convenient method of transporting large quantities of boards. Please ring to find out and we will quote you our best prices possible.


text:
We use cookies to improve your browsing experience. By continuing to use our site, you accept our cookie policy.
Charpy Impact Striker, 8 mm Radius, ASTM E23-12C.
Certification of Dimensional Conformance is provided.
Also complies with ISO 148-2:2009.
Please confirm that you agree with our privacy and cookies policy to submit this form.
I agree to the terms & conditions of Instron's Privacy and Cookies Policy.
Subscribe to Instron News!
Check this box to receive pertinent commercial email from Instron focusing on products, upcoming events, and more!


text:
Jobs for teenagers at Fareway stores. Minimum age to apply is 14 years old. Find Fareway near you and apply for jobs now.
Part-time, full-time, temporary, summer and any other seasonal jobs for 14, 15, 16 and 17 year old teenagers in other retail stores in the United States.
Jobs for teenagers at Fareway stores. Minimum age to apply is 14 years old. Find Fareway near you and apply for jobs now.
Jobs for teens at Vera Bradley stores, design company which produces and sells a variety of products, including quilted cotton luggage, handbags and accessories in more than 4,000 Vera Bradley retailers and stores. Minimum age to apply is 18 years old.
Apply jobs for teens at Babies "R" Us as Assembler, Store Receiving Specialist, Stock Clerk, or Baby Registry Sales Consultant. Minimum age is 16 years. Babies "R" Us is a well-known children's goods store and is available in many states.
Find jobs for 15, 16, 17, 18 and 19 years old at Hershey's Chocolate World, Hershey's marketplace shops and restaurants in Hershey, Pennsylvania.
Jobs for teenagers at HomeGoods, a home furnishing store with 400 stores operated across the United States. Apply jobs as Coordinator, Customer Service Coordinator or Sales/Merchandise Associate.
Jobs for teenagers at Sweet Frog (frozen yogurt retail). Minimum age to work is 16 years old. Find Sweet Frog in your area and apply as a Team Member.
Jobs for teenagers at West Marine (retail store). Minimum age is 16 years old. Apply as Cashier, Sales Associate, Stock Associate, or Assistant Manager.
Jobs for teenagers at Teavana (tea retail store). Minimum age is 16 years old. Send your online job application as Supervisor or Barista.


text:
VINTAGE PFLUEGER PROGRESS SKELETON BRASS FLY FISHING REEL 80 yd BULLDOG MARK
http://thumbs.ebaystatic.com/pict/251259360010_0.jpgUS $27.55 (3 Bids)
End Date: Monday Apr-15-2013 13:55:21 PDT
Bid now | Add to watch list
|All times are GMT -5. The time now is 01:58 PM.
Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2017, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO 3.6.0
2005-2017 The North American Fly Fishing Forum. All rights reserved.


text:
After Trump rebuke, Sessions shows up for work, will stay ?as long as that is appropriate?
Attorney General Jeff Sessions and Deputy Attorney General Rod Rosenstein dodged questions about their future with the Department of Justice following criticisms from President Trump. In an interview with the New York Times published Wednesday evening, Trump said that he would not have appointed Sessions as attorney general if he knew Sessions would recuse himself from the Russia investigation. ?We in the Department of Justice will continue every single day to work hard, to serve the national interest, and we wholeheartedly join in the priorities of President Trump,? said Sessions when asked if he had considered resignation.
Scaramucci Hints at How He'll Deal With Trump's Tweets
Anthony Scaramucci, the new White House Communications Director, answers a question from NBC News' Hallie Jackson about getting the White House back on track.
Illinois man charged with Chinese scholar kidnapping pleads not guilty
An Illinois man charged with kidnapping a female Chinese scholar who has been missing for more than a month pleaded not guilty during an appearance in a U.S. court on Thursday. Brendt Christensen, 28, is accused of abducting Yingying Zhang, a 26-year-old visiting scholar at the University of Illinois from southeastern China, who disappeared on June 9. Zhang, who had been studying photosynthesis and crop productivity, was last seen when a security camera recorded her getting into a black car that authorities linked to Christensen, according to court records.
The Latest: Venezuela UN diplomat calls on Maduro to resign
CARACAS, Venezuela (AP) ? The Latest on Venezuela's political crisis and the opposition's general strike (all times local):
Germany cannot scare Turkey with 'threats': Erdogan
Turkish President Recep Tayyip Erdogan on Friday told Germany it cannot scare Ankara with threats, in an escalating row over a wave of arrests that prompted Berlin to step up warnings to German tourists and investors. "They (Germany) cannot scare us with these threats, they should know this," Erdogan said in a speech in Istanbul. "You (Germany) do not have the power to smear Turkey... or the power to scare us," he added.
USS Fitzgerald crash that killed seven American sailors 'was navy's own fault'
A deadly crash between a US warship and a Philippine cargo vessel is believed to have been the fault of the US navy, according to CNN citing preliminary investigations into the incident which claimed the lives of seven American sailors. The network said that two officials from the Department of Defence said that there were multiple errors by the crew of the USS Fitzgerald that led to the collision in June. The crash between the Fitzgerald, an Arleigh Burke-class destroyer, and the ACX Crystal on 17 June claimed the lives of seven US sailors.
Great White Shark Gets Shockingly Close To Paddle Boarders Near California
Paddle boarders came dangerously close to a great white shark in Califonia waters.
Man Fatally Stabs Dog That Sided With Girlfriend in Arguments: Cops
Cops in Florida say Mike Lado was angry the dog, Blue, showed favoritism toward his live-in girlfriend.
In surrealist twist, Dali exhumed in paternity lawsuit
FIGUERES, Spain (AP) ? Salvador Dali's eccentric artistic and personal history has taken yet another bizarre turn with the exhumation of his embalmed remains in order to find genetic samples that could settle whether one of the founding figures of surrealism fathered a girl decades ago.
Powerful earthquake hits Greece and Turkey
A deadly 6.7-magnitude undersea quake hit the Greek holiday island of Kos and the Turkish resort of Bodrum on Friday, injuring hundreds in areas abuzz with nightlife.


text:
The Hotel Panorama Bungalows Resort is directly on the beautiful sandy beach and will appeal to singles, couples, golfers and families looking for pleasant accommodation in Egypt.Also the guests enjoy the waterfront elegance and charm of the Marina, traditional Arabic architecture, modern amenities. Panorama Bungalows Resort offers optimum pleasure through the exclusive architectural style of the overflowing bungalows and the wide array of fun and leisure activities that meet all interests.
Greek style Panorama Bungalows Resort located direct on a beach and just 20km far from Hurghada international airport. The town centre has plenty of bazaars and mosques and a lively atmosphere. The Red Sea is known for its diving and good visibility.Scuba diving and snorkeling will allow you to view the reefs, where there`s a variety of corals and colourful fish life.
The Panorama Bungalows Hotel has 3 outdoor swimming pools and a seperate children`s pool. There is also a mini aqua park with slides and large terraces with free loungers and parasols.All rooms and bungalows have a bathroom,WC, hairdryer and are eguipped with direct dial telephone, A/C, TV, Mini-Bar, well as an in-room safe.
* Air conditioning
* Balcony or Terrace
* Beachfront
* Children's club
* Children's playground
* Children's pool
* Daytime Entertainment
* Evening Entertainment
* Hair dryer
* Heating
* Outdoor pool
* Pool table
* Reception - 24 hrs
* Safety deposit box
* Sauna
* Shop
* Shower
* Shows
* Sunbeds
* Table tennis
* Telephone
* Water sports
* Wi-fi in rooms


text:
Hi guys,
i need small pices of code , since the software which i have did not allow me to open more than one buy or sell positions.
if i opened position for buy Eur/Usd at 1.3340 (after I added some condition ) then I need to open an other buy Eur/Usd position! Is there any way to do that one ?


text:
By Amir Mir
Mauricio Pochettino has stated Tottenham need to be more "consistent" in the future after their 2-0 victory over Manchester City on Sunday afternoon.
Spurs inflicted the first defeat on Pep Guardiola's Manchester City at White Hart Lane to go within a point of the Premier League leaders.
Aleksandar Kolarov converted into his own net after nine minutes, with Dele Alli doubling his sides lead, just before the break, as the north London club moved to 17 points from their opening seven games.
Manager Pochettino who masterminded the victory hailed the "fantastic" performance from his side, but insisted that it is too early in the season.
"It was a fantastic victory," Pochettino told the club's official Twitter account. "But, it's only early in the season. We need to be consistent in the future."
Mauricio: "It was a fantastic victory but it's only early in the season. We need to be consistent in the future." #COYS pic.twitter.com/fXkfxYoxj1
— Tottenham Hotspur (@SpursOfficial) October 2, 2016
Spurs have now picked up five wins on the trot in all competitions heading into the international break.
The north London club have registered four consecutive league victories, including five wins overall, as they are now the only unbeaten side in the league.
Pochettino's side travel to the Hawthorns after the international break, as Spurs take on Tony Pulis' West Brom on October 15.
In other Tottenham team news, Harry Kane delivers Twitter verdict following Spurs' 2-0 victory against Manchester City.


text:
THE final UFC event of 2011 will be headlined by the heavyweight fight between Brock Lesnar and Alistair Overeem - provided the Dutchman passes TWO pre-fight drug tests ahead of his December 30 bout.
A tense hearing of the Nevada State Athletic Commission (NSAC) decided to grant Overeem a conditional licence to fight after the Dutchman had originally failed to provide a suitable urine sample for testing within the commission's required timeframe.
There had been a growing rumour that Overeem, a former K-1 kickboxing and Strikeforce MMA heavyweight champion, may have failed an out-of-competition drug test, but following Monday night's meeting of the Nevada State Athletic commission, it transpired that Overeem submitted a late urine test after initially providing an incorrect sample.
Overeem was in the USA filming the UFC's Countdown to UFC 141 show when he received news of a possible cancer relapse for his mother back in Holland. He made arrangements to fly back to his homeland, buying a ticket on November 15th and making the flight back from Las Vegas two days later on the 17th.
That same day the NSAC sent a communication to Overeem's representatives stating that urinary testing samples were to be submitted for steroid screening.
Overeem, during testimony under oath, explained that he hadn't been informed of his obligation to undertake a test before he took off for Holland. During questioning he detailed the timeline of events, explaining the ticket for his flight home was bought two days before the request was made, and he flew before he had received word of the test. Overeem also stated he wasn't told the test had to be a urine-based test.
Following a blood sample test taken by his own sports doctor - rather than a drug-testing facility - in the Netherlands, and the following the necessary wait for results, Overeem's assistant communicated back to him that the test was insufficient for the NSAC.
Overeem then returned to his sports doctor's facility the following morning (December 12) to undergo the required urine test. The results of these tests were unavailable to the commission at the time of the hearing.
During their deliberations, the commission expressed their appreciation for Overeem's circumstances regarding his mother's ill health, but also highlighted their concern for a lack of urgency on Overeem's (and his representatives') part.
An original motion for a conditional licence, stating Overeem's submitted urine test of December 12th must come back clean as well as the stipulation of two further random tests following the Lesnar bout, was thrown out with no other commission member prepared to second the motion.
Following further deliberations the commission passed a motion allowing Overeem to compete.
Under the conditions of the licence, Overeem will have to provide a new urine sample at a suitable testing facility (possibly in the UK) as directed by the NSAC. Assuming that test is passed, he will then have to be tested immediately upon his return to the US ahead of his bout with Lesnar. And following the bout he'll be randomly tested twice within the six months following the Lesnar bout.
The passing of that motion and Overeem's subsequent licencing means that "The Reem" is sanctioned to face Brock Lesnar in the main event of UFC 141 at the MGM Grand Garden Arena in Las Vegas, Nevada, on December 30th.
November 15: Overeem buys flight ticket to return to Holland
November 17: Overeem flies back to Holland. NSAC request Overeem take a urine-based drugs test.
November 21: NSAC receives no word from Overeem camp regarding drug test. Then NSAC discover Overeem had flown back to Holland.
November 23: Overeem takes blood-based (not urine-based) drug test with his sports doctor, not a recognized testing facility. Test results come back clear, but test was not a specific steroid test.
December 6: Overeem receives word his blood-based test did not satisfy regulations.
December 7: Overeem returns to his sports doctor and undergoes a urine-based drug test
December 12: Overeem appears, via telephone, in front of the NSAC to answer his case. Following deliberations, Overeem is granted a conditional licence to fight in the state of Nevada, clearing him to face Brock Lesnar at UFC 141 on December 30, subject to two clean pre-fight drug tests.


text:
This property is no longer available.Search for Available Property.
5 acres in Searcy County, Arkansas
5 acres +/- mixed use recreational, timberland located in Searcy County, Arkansas. The 5 acre property also known as Tract #7 is just outside Saint Joe, AR 72675. This property would be a great place for a getaway cabin or a rental cabin with easy access to utilities. It is just minutes from the Buffalo National River where lots of recreational opportunities can be enjoyed such as public land access, equestrian trails, hiking trails, floating, kayaking, hunting, and fishing. The wildlife consist of bear, elk, turkey, and whitetail deer. Call Today! Exclusive Listing Agents Gene Griffith 870-504-0854, Jennifer Griffith 870-504-1002, and Jordan Pinson 870-504-2001. Mossy Oak Properties Delta Land Management Marshall Branch 870-447-2135.
Tax Data (Show Tax Data)
Loading Tax Data
Other Land for Sale in Searcy County
NOTE: The information contained herein is provided as general information only and has been obtained from sources deemed reliable. It is provided without any guaranty, warranty or representation, expressed or implied, made by Lands of America, or any related entity, as to the accuracy or completeness of the information. The information is presented subject to errors, omissions, change of price or conditions, prior sale or withdrawal without notice. Prospective purchasers should make their own investigations, projections and conclusions concerning the information.


text:
With six grandchildren waiting patiently at home on Christmas Eve, David Lee had already spent the spoils of a rare city win before Episodes had even returned to scale at Warwick Farm on Wednesday.
"He will pay for the presents for six grandkids," an excited Lee said. "They're aged from three to eight, twins in there, so it's pretty good."
Even better that Lee owns 50 per cent of the gelding as well after travelling to the Scone Select Yearling Sale on a whim hoping to snap up a similar bargain to Departed, a handy $30,000 buy from two years earlier.
The budget was only $10,000 and that is exactly how much Lee spent to travel home with Episodes alongside son Jason, a former jockey still riding plenty of work at Randwick.
"I said to Jason, 'we'll go to the sales and we had a limit of $10,000 ... that's it'," Lee said. "They said to look at this one horse, he was the best type, and we got him for $10,000.
"Jason rode him in work on Saturday morning and said, 'dad, it won't get beat'. I rode him in work on Monday morning, just worked him 600 [metres], and I thought he would win."
And that's exactly what happened after Sam Clipperton traversed a three-wide passage before striding to the lead and holding off a late charge from Impressive Yield.
Lee reasoned his last Saturday metropolitan win was more than a decade ago when Chris Munce and Jim Cassidy rode Nordic Flight to back-to-back victories in 2003. Wednesday winner? He couldn't remember.
"It's great to get a winner for Dave as he has been a close friend for a long time and it's good to see him get a winner in town," Clipperton said.
If David Lee was on the small scale of stables Clipperton now commands rides from, Godolphin is at the other end of the spectrum.
The in-form hoop made it a winning double when Hebden kept her unbeaten record in tact at its second start.
"He's always shown a lot of promise, but I think riding for a big yard like this it gives you a lot of confidence even being asked to ride a horse for them," Godolphin assistant trainer Darren Beadman said.
"I know when I was riding your confidence went up and I'm sure it's the same for him."
Clipperton was only denied a race-to-race treble after Kris Lees' Selectify arrived in the nick of time to deny Clipperton on Peter Moody's Fight To The Line.
Meanwhile, jockey Padraig Beggy has had an appeal against the severity of a drug-related suspension dismissed and will remain out of the saddle until at least mid-September next year.
Beggy was hit with five charges when a urine sample given after riding at the Kembla Grange barrier trials in September returned traces of cocaine.
Beggy first claimed the cocaine irregularity was a result of an anaesthetic used by his dentist and later the ingestion of coca leaves provided by a friend before later admitting he took the drug at a barbecue three nights prior to riding at the trials.
He told steward Marc Van Gestel he was boarding a flight to Cairns, contradicting the stipe's evidence he was already in far north Queensland, when later directed to provide another urine sample at Hawkesbury racecourse.
The appeals panel upheld the six-month suspension for knowingly giving false evidence on four counts on top of the nine-month ban for taking cocaine.
He will be able to return on September 19 next year if he provides stewards with evidence of satisfactorily completing professional counselling.


text:
It appears your browser may be outdated. For the best website experience, we recommend updating your browser. learn more
Shot of the Day: July 6, 2012 from The Old White TPC
In the second round of The Greenbrier Classic, Steve Stricker's approach shot hits the flag stick on the par-4 16th hole.
© 1995-2017 PGA TOUR, Inc | All Rights Reserved.
PGA TOUR, PGA TOUR Champions, Web.com Tour, and the Swinging Golfer design are registered trademarks.
Web.com is also a registered trademark used here with permission, and used in the Web.com Tour logo with permission.


text:
Author Tags: Forts and Fur
Born in 1927; biographer and relative of Archibald McDonald.
[See Archibald McDonald entry.]
Review of the author's work by BC Studies:
This Blessed Wilderness: Archibald McDonald's letters from the Columbia River, 1822-44
Exile in the Wilderness
Cole, Jean Murray. Exile in the Wilderness: the Life of Chief Factor Archibald McDonald, 1790-1853 (Don Mills: Burns & MacEachern; University of Washington Press, 1979).
[BCBW 2004] "Forts and Fur"


text:
Pay-Per-Minute Viewing
You can now enjoy this movie on your iPhone®, iPad®, or compatible Smart TV & Android devices.
Purchase Options
Pay-Per-MinutePurchase Minutes
Streaming Rentals
Available MP4 sizes:SD 480p (1.81 GB)
DRM-free downloads offer content that is not limited by standard Digital Rights Management (DRM) access technologies. These technologies allow hardware manufacturers, publishers, copyright holders and individuals to limit the usage of digital content.
When you purchase DRM-free downloadable content, that content is available for you to download on any computer and save to a disk whenever you like. You can also download to multiple computers. There is no timeframe associated with your purchase and the content will not expire.
Running Time: 120 minutes
Released: 03/2010
Studio Name: Universal Trannies
Series: Massive Shemale Breasts
Categories: Shemale Big Tits Transsexual All Sex
Description: Universal Trannies is ready to share their love of some fantastically shaped shemale breasts with you! Watch the sexiest shemales with gifted upper bodies show off their goods before they strip, jerk off, suck dick, and get fucked!
5 Scenes from Massive Shemale Breasts
Watch with a Subscription to the SuperPass Channel, with Pay-Per-Minute or Streaming Rental
Massive Shemale Breasts: Scene 1 Free Preview
Sex Acts: Anal Sex, Masturbation, Oral Sex
Positions: Standing Doggy Style, Standing, Standing Missionary, Sitting, Missionary, Laying, Cowgirl, Doggy Style
Settings: Patio
Massive Shemale Breasts: Scene 2 Free Preview
Sex Acts: Modeling, Masturbation, Anal Sex
Settings: Living Room
Massive Shemale Breasts: Scene 3 Free Preview
Sex Acts: Breast Play, Masturbation, Oral Sex, Anal Sex
Positions: Standing, Sitting, Standing Doggy Style, Standing Missionary, Reverse Cowgirl, Cowgirl
Settings: Patio
Massive Shemale Breasts: Scene 4 Free Preview
Sex Acts: Breast Play, Anal Sex, Oral Sex, Masturbation, Blowjob
Positions: Standing, Sitting, Standing Doggy Style, Kneeling, Missionary, Laying, Cowgirl
Settings: Outdoors
Massive Shemale Breasts: Scene 5 Free Preview
Sex Acts: Anal Sex, 3-Way, Masturbation, Oral Sex, Tittie Fucking
Positions: Reverse Doggy, Standing, Side Saddle, Spoons position, Laying, Reverse Cowgirl, Cowgirl, Kneeling
Settings: Bedroom
Recommended Movies
AEBN Cams


text:
I have a few PCs that is not scanned. What are the requirement for a system to be detected in the scan?
This topic was created during version 5.3.
The latest version is 7.5.00101.
3 Replies
Feb 29, 2012 at 8:23 UTC
What OS is on the system in question?
Look here for some help...
Feb 29, 2012 at 9:37 UTC
This how-to is for various scan errors.
and this one is for inventory inconsistencies, step 1 to 3 atleast.
Feb 29, 2012 at 10:29 UTC
GreyRose LLC is an IT service provider.
WMI, DCOM, Firewall must not be blocking, AV must not auto-sense and be closed off to Spiceworks' scans, cable unplugged, users turning off the monitor... Any number of reasons can stop the scans from working.
I suggest you spend some time reading the forums here and reviewing the Help Documentation that covers this subject. When you have tried a few solutions and determined what is or is not working, please return and inform us with the steps taken, what systems you're running in to problems with and other pertinent facts that relate to the steps you took to see that the scans aren't coming in properly and what you did to try to resolve them. Screen shots are helpful.
Good luck and welcome to the community. Be sure to fill out your profile! When you update your picture here, it updates in your Spiceworks installation, too!
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


text:
My org does several conferences a year, and we bring our own projectors, since the venue will charge from $500 to $1000 per day for them if we rent. We've had problems in some larger venues with the 3000 lumen 1024x768 models not being bright enough in some of the larger rooms.
Will I notice a huge difference going up to the 5000 lumen range? (It doesn't sound like I can practically go much higher than that)
Will such a projector be too loud for a small room?
I suspect with such a big dog projector that the keystoning effect will be more pronounced... Wouldn't it be preferable to get a lens shift correcting projector instead of the el-cheapo digital keystone correction?
I've obviously thought about this a lot, and read about them a fair amount. I'm mostly looking for what I've overlooked, and model numbers.
5 Replies
Nov 4, 2011 at 2:52 UTC
go big or go home
Nov 4, 2011 at 3:32 UTC
Optoma makes some very quiet 5000 lumens projectors.
Nov 4, 2011 at 4:12 UTC
Probably the reason why the 3000 lumen projectors are dim to you is because they never bother to replace the bulb.
You might be fine with the 3000 ones, just get someone to give you a fresh demo unit.
Nov 6, 2011 at 8:39 UTC
+1 on testing to see whether the bulb is actually still putting out 3000 lumens.
Nov 7, 2011 at 7:01 UTC
Well, I do pretty aggressively watch the hours on each bulb. Right now even the oldest of them isn't even at 800 hours yet. The model we have (Dell 2400MP) says their bulb should work for "up to" 2000 hours... I don't expect them to last that long, but they're far enough away from that for me to have ruled that out.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


text:
ANALYSIS: European vehicle production to hit pre-recession highs by 2014
Forecasters are predicting a more positive outlook than first expected for European automotive production during the next four years, with a strong indication that output will return to the pre-recession highs of 2007 by 2014.
Get full access to all content, just $1 for 30 days
A Message From The Editor
just-auto gives its paid members access to the very best automotive market coverage.
And now there's just-auto plus, our premium membership that gives you exclusive component forecast data, company profiles and extended news coverage - just for premium members.
Today I can offer you 30 days access for $1 - and that includes just-auto plus.
Dave Leggett, editor of just-auto
* plus VAT if applicable
Only on


text:
All of the following are true except
The role of negative feedback system is to bring it back to Set point
The role of a positive feedback is all about destabilizing the system and amplifying the signal
Blood clotting, uterine contractions in response to oxytocin are examples of positive feedback
None of the above
All of the following are true about diffusion is dependent
It is dependent on the cross sectional area thru which the flow of solute is measured
The difference in solute concentration between regions
The distance (or thickness) between regions A and B
The lipid solubility of the solute
The difference in solvent concentration between regions
All of the following are true about diffusion except?
IF you increase the molecular size the Net flux increases
The more the solubility in lipid the faster that molecule diffuses (like CO2 vs O2)
The thinner the membrane the faster the net flux
larger the concentration difference the faster the net flux
In osmosis there is net movement (passive) of Water across a semi permeable membrane
When thinking about Tonicity, think ONLY about NaCL
The following are the sequence of events if you add water to ECF - all are true except?
ECF will be diluted compared to ICF
Water will move from ECF to ICF
Increase in ECF volume and decrease in ICF volume
Once it reaches equilibrium both ECF and ICF will have the same osmolarity
Protein Mediated Transport rate will be faster with increase in substrate concentration
All of the following about Cardiac glycosides (digitalis) are true except?
Blocks NaK ATPase
Increase the ICF concentration of Na and decrease the ICF concentration of K
This will increase the chemical gradient for Na to come into the cell
Ca antitransporter slows down which increases the ICF conc of Ca thereby increasing contractility
All of the following are true about RMP except
When RMP = -110 mv inside is more negative --> draws K into the cell and it is hyperpolarized enough to have more K coming in than leaving, despite that being against it's conc gradient
When RMP = +30 inside is more positive than the outside -->both the electrical and chemical gradient is pushing K out of the cell
none of the above
Generation of resting membrane potential - all the following true except?
if only K is permeable, Equilibrium potential for K will determine the RMP and it will be -94mV
If only Na is permeable then the RMP would be +60mV (which is the equilibrium potential for Na)
When there are 2 ions moving (back of forth thru the membrane) the RMP will be determined by the ion with the greater number of leaky (non-gated) channels
Increasing the ECF concentration of NA makes the RMP more positive
If you make the membrane even more permeable to K - then the membrane will be hyperpolarized
All of the following are true about Electronic Potentials except?
Subthreshold depolarizing events
Chemical, mechanical stimuli
Polarity inside positive
Does not propagate
No refractory period
All are true about Action potential except?
All or nothing event
Chemical or mechanical stimuli
Polarity with inside positive
Refractory period (including Absolute refractory period)
All of the following are true except?
At rest - membrane is most permeable to Na
At Threshold - voltage-gated Na channels open
Rising phase and overshoot - membrane becomes so depolarized that it overshoots and is reversed in polarity
At or near the peak the Na permeability begins to decrease and K permeability through voltage-gated K channels increase (Both channels open in response to hitting Threshold, just Na open much faster)
Repolarization - Na voltage gated channels have started closing and voltage gated channels are opening
After hyperpolarization - voltage gated K channels are still open but they will gradually close at this point
TEA (tetra ethyl ammonium)
Block K current
Repolarization is affected
You can still get an AP (action potential) with this
all of the above are correct
TTX (Tetrotoxin) and Saxitoxin (STX)
Block Na voltage gated channels
Affects repolarization
cannot trigger an AP
All of the following about AP are true except?
AP is initiated at axon hillock - where there are the greatest number of voltage-sensitive gates are located
Nodes of Ranvier will increase the propagation of the AP
Inhibitory Post synaptic mediators like GABA will activate Cl- channels which causes and influx of Cl- which in turn will hyperpolarize the cell
the slower the Time Constant the greater the Propagation Velocity
The greater the Length(space) Constant the shorter the membrane will stay depolarized
Electrical Synapse has Bidirectional flow whereas a Chemical synapse has Unidirectional flow
The Following is the sequence of events at the synapse
An AP arrives at the presynaptic terminal
Voltage-gated Ca channels open and Ca enters the cell
This Ca triggers the fusion of synaptic vesicle with the post synaptic membrane
NTM (neuro transmitter) diffuse across the synaptic cleft and bind to the specific receptors on the post synaptic cell
Bound receptors will activate the post synaptic cell and the NTM breaks down and is taken up by the pre synaptic terminal or other cells or diffuses away from the synapse
All of the following about the toxins are true except?
Conotoxin will inhibit the release of NTM
Tubocurarine and Bungotoxin block the AcH receptors
Tetanus toxin cleaves synaptobrevin - prevents the release of GABA - causing spastic paralysis
Botulin cleaves synaptobrevin - prevents the release of Ach - flaccid paralysis
Metabotropic receptor acts through a secondary messenger
Inhibitory Postsynaptic Potentials (IPSP) act either by Opening of Cl- or K+ channels
NE is the primary excitatory transmitter for postganglionic neurons of the sympathetic nervous system
Degeneration of Dopaminergic neurons in substantia Nigra leads to Parkinson's disease
Dopamine can be used as treatment for Parkinson's disease
All of the following are inhibitory NTMs except
All of the above
Nicotinic receptors are Metabotropic whereas Muscarinic receptors are Ionotrophic
NMDA receptor is specifically excitatory glutamate receptor for which Glycine must also be bound for the ion channel to open
Temporal summation occurs when consecutive synaptic potentials arrive at the postsynaptic cell and add together
PCP(phencyclidine) is the antagonist for NMDA receptor


text: Contents[show] Sex : Male PedigreeEdit Son of Terah Full NameEdit Haran BiographyEdit SiblingsEdit Abraham Nahor Spouse(s)Edit OffspringEdit Lot Milcah Iscah SourcesEdit Book of Genesis ReferencesEdit Retrieved from "http://familypedia.wikia.com/wiki/Haran_ben_Terah?oldid=719100" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Biblical figuresNon-SMW people articles


text:
Not Accepting Guests
- Last login 8 months ago
Join Couchsurfing to see Katja's full profile. It's free!
About Me
No available couch at the moment, soz. Hopefully one day I won't live in a shoebox with a husband and a cat (would like to keep the two latter and lose the shoebox part).
I love travelling when budget allows. I especially love going to gigs and festivals around the world. I love anything from alternative music to cheesy pop, and meeting fellow fans is always a joy.
Why I'm on Couchsurfing
I might be a little socially awkward, but I like people. So if you're going to see a good gig, ask me to tag along!
Music, concerts, books (second-hand book shopping is a must anywhere I go!), geeky things (conventions are always cool!).
- cats
- books
- concerts
- festivals
- shopping
- traveling
- music
- alternative music
Countries I've Visited
Japan, United Kingdom
Countries I've Lived In


text: You would be forgiven for thinking that MWC is about the wrist rather than the hand. The traditional mobile phone is here in Barcelona, but increasingly, we're hearing about wrist-based technology that goes with it. Yesterday, we had the Samsung Gear 2 and Gear 2 Neo smartwatches and today we have the Gear Fit from the same company. But don't go thinking this is all about Samsung.The Samsung Gear Fit is essentially a health tracker and as such, one in the eye for Apple, which is expected to use health as the key selling point for its upcoming iWatch. Samsung is already here with a device that will certainly sell on looks.Whether it works in terms of functionality remains to be seen. But the signs are good. Within that colourful strap (or band, which is replaceable) you'll find a curvy 1.8-inch Super AMOLED touchscreen with a 432 x 128 resolution and a 210mAh battery, which should be good for three or four days between charges, longer with less use.Beyond that, there is an accelerometer, pedometer, a heart rate detector and Bluetooth 4.0, the latter able to transfer all the vital statistics about your health and training back to your smartphone, where you can record, analyse or worry, depend on what you see.But it's not all about fitness. This little device can also keep track of your calls, texts, calendar appointments and more via a series of notifications. So no need to keep checking your phone in the gym - check your wrist. That is of course, if you have a Samsung Galaxy phone. It doesn't work (as yet) with other models. The Gear Fit will have those changeable straps in a choice of black, orange or mocha grey, with the device itself available from 11 April (same day as the Galaxy S5). No pricing available for the UK as yet.However, if you are thinking of investing, you might want to sit back and wait for the competition to arrive first. With the Sony SmartBand SWR10, that's sooner than you think.Sony showed off its own smartphone companion back at CES, a SmartBand with removable Core that tracks your wellbeing. So how many calories you've burned today, how well you are sleeping and if you like, when you should wake up for optimal sleep. All of that data syncs with the Lifelog Android app to keep a track of how well you are doing. Just pair it via Bluetooth or NFC to your phone.Sony is promising that from March (which is only days away), but has yet to confirm a price.Apple, of course, is the key rival to Samsung in this. We have heard that health will be the key selling point here too, with the company launching its Healthbook software to go alongside the rumoured iWatch, an app that monitors and stores fitness statistics, checks your vital signs and can even remind you to take medication. A doctor in your pocket was how we saw it.Interestingly, a recent Apple patent points to monitoring via earphones and headphones too, with movements and vital signs monitored through a series of embedded sensors. So Apple could have multiple (or connected) devices later this year. Interesting. Expect more on this as the weeks and months pass.HTC has also confirmed that a smartwatch is incoming, with HTC Chairwoman Cher Wang stating in an interview that a watch more fashionable than your average smartwatch was on the agenda. HTC is working on battery efficiency for the device and plans to have it on the shelves by Christmas. Beyond that, little is known. But it will be big news.Finally, if you are after a budget option, you might want to wait for the Huawei Talkband B1, which does have its own unique selling points. First off, the price should be one, with talk of around £80 for this particular band. That's for a smart device which is likely to do the tracking for health and sleep, but also allows you to make calls. Yes, just like the sci-fi movies of old. It also supports both iOS and Android, which opens up the market significantly.Again, just in prototype mode right now, with an eye on the second half of the year for a launch. It all points to a smartwatch Christmas, especially if Apple gets a device out this year. You'll be out of place at the gym without one by 2015.


text: On Pete's World, Stevie was a party guest at Jackie Tyler's "39th" birthday party in 2007. At the party, Pete Tyler greeted him, asking "How's it going with Torchwood?" (TV: Rise of the Cybermen) After Jackie's party was attacked by the Cybermen, the Tenth Doctor assured Pete that "Anyone inside that house is dead." (TV: The Age of Steel)


text:
It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the website.
This step is voluntary but will dramatically increase your chances of getting interest from other over 50s members on the site. Let people know a bit about yourself, your interests and attach a nice photograph of yourself.
Utilise our website's state-of-the-art search to pinpoint over 50s members who satisfy your requirements. Or just browse through listings and pinpoint singles that you find attractive.
Discovered someone who you like the look of? Drop them a line or just a wink and see how you get along. With a little luck you'll be on your way to a lifetime of happiness.
It'll only take 30 seconds