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A quick Google search will bring up images of Devin Hester in a red Atlanta Falcons practice uniform.
For Chicago Bears fans, it must be a strange image. Gone are the days when Hester brought you to the edge of your seat every time he stepped on the field to return a kick or punt. Those are now distant memories.
The problem for the Bears is that no player has stepped up to claim Hester's role. The club has a number of potential replacements, players who will battle it out in training camp for the right to be Chicago's starting returner.
During veteran minicamp, coordinator Joe DeCamillis outlined what he'll be looking for during the team's three weeks on the campus of Olivet Nazarene University.
"The first thing is returner mechanics," DeCamillis said. "You want a guy who can make all the catches. You want a solid punt return guy that can square up his body, make sure he makes the right decisions, because that's really the biggest part of being a returner is making the right decision, in my opinion.
"Then the second thing is the talent with the ball in his hand. If you can identify a guy that can make plays in open space, that's really what you are looking for. And it happens in different ways. Devin had great speed, that's why he was good. And there's been other guys that have excellent vision and they're good, so you just have to find what that guy is good at and try to tailor the scheme towards him."
Let's break down in detail this competition, which will play out in Bourbonnais in less than three weeks.
The Frontrunner
Late last season, the Bears made a Week-17 roster move that received little attention. The club signed Chris Williams, who spent the last three seasons in the Canadian Football League. Williams is a former 2009 undrafted free agent who has spent time on the practice squads of the Dolphins, Browns and, most recently, the Saints.
He has yet to log an NFL snap but Williams was an accomplished returner during his three years as a member of the Hamilton Tiger Cats. In 2012, he returned six kicks for touchdowns, which set an all-time single-season CFL record.
Williams is lightning quick and has blazing speed. He ran a 4.28 40-yard dash during his pro day and told me during minicamp that wasn't even his fastest time. That speed showed up on the practice field this offseason, as Williams is by far the fastest player on the roster.
His biggest hurdle is his size (5-7, 175), making him also the smallest player on the roster. It's hard to imagine Williams taking a big hit from a 250-pound linebacker with a full head of speed and getting up. If he proves durable, though, Williams should win this contest.
While his size could hurt him in the injury department, his low center of gravity makes him exceptionally quick on his cuts. Williams explodes from a stand still and is at full speed almost immediately. His burst and straight-line speed will make him a homerun threat every time he touches the ball.
The Challengers
The Bears signed Domenik Hixon this offseason as one of the main competitors for the returner role. He unfortunately tore his ACL during the first practice of OTAs and is out for the season.
GM Phil Emery immediately signed Michael Spurlock and Armanti Edwards, both of whom are experienced returners.
Spurlock (5-10, 214) is a 30-year-old journeyman who has played for seven different teams in seven NFL seasons. He's returned 81 career punts (9.6 avg.) and 107 kick returns (24.2 avg.). In 2013, he played 10 games for the Detroit Lions, averaging 6.6 yards on 22 punt returns and 22.5 yards on 15 kick returns.
Edwards (5-11, 190) spent his first three-plus NFL seasons with the Carolina Panthers but the team waived him after four games. He signed on with the Cleveland Browns but was waived after two games.
Edwards has 40 career punt returns (7.0 avg.), 32 of which came in 2012, and 15 career kick returns (19.7 avg.). He hasn't accomplished much in his career but he does have good speed, running a 4.41 at his pro day in 2010.
Spurlock and Edwards were immediately inserted into the punt and kick return rotation during OTAs and minicamp, where they'll likely stay throughout the preseason.
The Veteran
Most forget the Bears already possess a Pro Bowl kick returner in Eric Weems. For the Atlanta Falcons in 2010, Weems recorded a 12.8-yard punt-return average and a 27.5 kick-return average, with four combined touchdowns, earning him his first trip to Hawaii.
Since joining the Bears, Weems has seen very little action in the return game, returning just one punt and 18 kicks the last two years combined. With Hester on board, Weems was just a backup, but he now gets a true shot at earning the starting gig.
Weems is a tough, experienced returner who was very dangerous in his prime. He doesn't have great speed but he's intelligent, shifty and has good field vision. He recently turned 29, so he should have plenty of tread left on his tires. If he hasn't lost his burst, Weems could emerge as the club's starting returner.
Projected Winner: Chris Williams
Williams needs to show he can take the pounding of the NFL game. We won't know until the preseason if he's capable of withstanding the size and speed of most professional special teams players. He must demonstrate an understanding of how to take hits in a manner that protects his body, and when to get out of bounds or dive when a return breaks down.
If he takes too many hard, nasty looking hits in the preseason, it won't matter if he gets up or not, as it will show his vulnerability. Eventually, one of those collisions will lead to injury. For a player of his size, he has to eliminate as much contact as possible.
If he shows durability during Chicago's four preseason contests, Williams will emerge the starter. He's just too dangerous with the ball in his hands to pass up. Weems is going to make the team either way, as he has value at multiple positions on special teams, so he'll be waiting in the wings as Williams' backup. It's an ideal scenario, with a savvy veteran backing up a big-play youngster.
If Williams can't take the pounding, Weems will likely emerge the starter. Edwards and Spurlock will get plenty of opportunities to show their worth but neither has been all that impressive throughout his career.
The Bears' offense should be very good this year, so the team doesn't necessarily need big returns on every kick. Someone who can make solid decisions and get positive yards is the ideal candidate, which is where Weems' experience will come into play.
Jeremy Stoltz is Publisher of BearReport.com and a member of the Pro Football Writers of America. He is in his fourth season covering the Chicago Bears full time. Follow Bear Report on Twitter and discuss this topic on our message boards. To become a subscriber to the Bear Report Web site or magazine, click here.


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Note: Each of the books in the Holland family saga are written as stand-alone novels. Each novel features a descendant of the original Hackberry Holland.
- Wafaring Stranger (2014)
- The Jealous Kind (2016)
Books featuring Hackberry Holland
- Lay Down My Sword and Shield (1971)
- Rain Gods (2009)
- Feast Day of Fools (2011)
- House of the Rising Sun (2015)

subset: commoncrawl


text:
Magnum Series Pushrods Chrysler 273-360
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Magnum Series Pushrods Chrysler 273-360, with adjustable rockers. 7.342" length 5/16" Dia.
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If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
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Description: "I call this book The Intent to Live because great actors don't seem to be acting, they seem to be actually living." -Larry Moss, from the Introduction When Oscar-winning actors Helen Hunt and Hilary Swank accepted their Academy Awards, each credited Larry Moss's guidance as key to their career-making performances. There is a two-year waiting list for his advanced acting classes. But now everyone-professionals and amateurs alike-can discover Moss's passionate, in-depth teaching. Inviting you to join him in the classroom and onstage, Moss shares the techniques he has developed over thirty years to help actors set their emotions, imagination, and behavior on fire, showing how the hard work of preparation pays off in performances that are spontaneous, fresh, and authentic. From the foundations of script analysis to the nuances of physicalization and sensory work, here are the case studies, exercises, and insights that enable you to connect personally with a script, develop your character from the inside out, overcome fear and inhibition, and master the technical skills required for success in the theater, television, and movies. Far more than a handbook, The Intent to Live is the personal credo of a master teacher. Moss's respect for actors and love of the actor's craft enliven every page, together with examples from a wealth of plays and films, both current and classic, and vivid appreciations of great performances. Whether you act for a living or simply want a deeper understanding of acting greatness, The Intent to Live will move, instruct, and inspire you. "From the Hardcover edition."
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This incredibly simple tool saves a work of headaches while working with lumber. It lifts timber off the ground and holds tightly, preventing slippage or turning over of the lumber. It also includes guides for marking and cutting, and a graduated ruler.
22-17324 - The Quad™ 14 Piece Saw/Driver Set
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Purchasing was easy, shipping was fast and the items were packed well.


text:
- Turndown
- Turndown Turn"down`, a.
1. Capable of being turned down; specif. (Elec.),
designating, or pertaining to, an incandescent lamp with a
small additional filament which can be made incandescent
when only a small amount of light is required.
[Webster 1913 Suppl.]
2. Made to wear with the upper part turned down; as, a turndown collar. [Webster 1913 Suppl.]
The Collaborative International Dictionary of English. 2000.


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In a nutshell....
Seedling tray with 42 vegetable plug plants and 6 of the most used herb plants for your herb and veg garden.
Please note we are experiencing a 10 day delay in all plant orders due to unusually high order numbers.
The Vegtrug plant tray is a collection of 42 vegetable plug plants with 6 herb plants. It is designed to fit our 1.8m Vegtrug raised vegetable planter bed but will also nicely fit in most raised garden beds. It includes a broad range of easy crops to give you an excellent introduction to vegetable gardening.
We've also included 6 of the most popular culinary herb plants in ths mix to make this selection the perfect herb and salad bed. You won't believe the breadth of flavour and texture you'll get from such a small space, this plant tray makes the vegtrug planters bloom!
Delivered In April / May
We send our vegtrug plant tray of herb and vegetable seedlings out in late April and May. We carefully grow them from seed in our plant nursery until they are 4-6 weeks old and theno harden them off before sending them out so they are ready for planting upon arrival. All our herb plants and vegetable seedlings are grown organically by our expert growers to ensure a greater success rate come harvest time.
The Vegtrug Plant try contains the following vegetable plants:
4 x Rocket
3 x Mizuna
5 x Beetroot
7 x Carrot
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7 x Lettuce Mix
2 x Swiss Chard
7 x Lettuce Mini Cos
and the following herb plants:
1 x Herb Thyme
1 x Herb Sage
1 x Herb Oregano
1 x Herb Rosemany
1 x Chives
1 x Parsley
Contains 42 vegetable plants, and 6 herb plants
Will fit a 1.8m vegtrug raised planter, or any 6x3ft raised garden bed with room to spare.
All our UK deliveries are only £3.95 no matter how many products we deliver anywhere in mainland UK. For heavy items like raised beds or ponds we charge only £7.95 per complete order. We also deliver to other European countries, please see our rates below.
Our delivery fee is an absolute bargain and is far cheaper than any of our competitors, please take this into account when comparing product prices.
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We deliver nationwide to the UK, the island of Ireland, Austria, Benelux Countries, Czech Republic, Denmark, Finland, France, Germany, Hungary, Italy, Norway, Poland, Portugal, Spain, Slovakia, Slovenia, Sweden and Switzerland. Please see our delivery rates below:
£3.95 - The United Kingdom and Island of Ireland (Highlands and Islands may incur a surcharge, please contact us on 0044 1788 298 795 for details)
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When the order has been dispatched we will provide you with a tracking number for your shipment, you will be able to log on to the Parcel Force website and see where your parcel is at any time. You can also call the office on 01788 298 795 or email email@example.com if you need more information.
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All items dispatched at the same time will normally be delivered in one delivery. The exceptions are bulk bags of soil or compost which comes in a separate delivery using a different delivery company.
What if my parcel is damaged or I wish to return the goods I have ordered?
Contact our office on 01788 298 795 and we will arrange collection and refund or replacement of faulty or damaged goods free of charge. We have a 'no quibble' policy on damages and will replace immediately once we receive an emailed photo of the damaged item.
If you wish to return an undamaged item for any reason we do charge a collection fee which may vary depending on the number of parcels, each case is different so please call us to arrange. We promise to keep returns fees fair and as low as possible. To arrange a return please contact our sales team on 01788 298 795
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text:
- Description
With plenty of room for your family and friends to get comfortable, the multifunctional Hankins Collection will be a welcome addition to your living room. The chocolate textured plush microfiber & dark brown bi-cast vinyl are the perfect complement to your transitional decorative style. Generously stuffed for your comfort and well-appointed for your convenience, this seating collection features an end reclining unit and chaise, as well as a console with cup holders and lift-up storage.Includes
1 SectionalDimensions
Sectional, 111 x 111 x 39H
Left Side Reclining Love Seat with Console, 67 x 37 x 39H
Corner Seat, 64 x 37 x 39H
Armless Chair, 22 x 37 x 39H
Console, 13 x 37 x 39H
Right Side Reclining Chaise, 32 x 59 x 39H
More from this collection: Hankins
- Additional Information
Additional Information
SKU 13402484 MPN 9669FCP GTIN UPC 782359192987, 782359193007, 782359192994, 782359192963, 782359192970 Brand Homelegance Collection Hankins Assemble Length 111 Assemble Width 111 Assemble Height 39 Assembly Required Yes Material Other Color Chocolate Styles Contemporary Shipping Time 2-3 Weeks Free Shipping No
- Reviews


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|Tangible Fixed Assets
|£ 271
|Current Assets
|£ 12,580
|Tangible Fixed Assets Depreciation
|£ 5,452
|£ 1,170
|Shareholder Funds
|£ 5,669
|Profit Loss Account Reserve
|£ 4,669
|Called Up Share Capital
|£ 1,000
|Total Assets Less Current Liabilities
|£ 5,669
|Net Current Assets Liabilities
|£ 5,398
|Creditors Due Within One Year
|£ 7,182
|Cash Bank In Hand
|£ 9,904
|Stocks Inventory
|£ 1,506
|Share Capital Allotted Called Up Paid
|£ 1,000
|Number Shares Allotted
|£ 1,000
|Tangible Fixed Assets Cost Or Valuation
|£ 5,600
|Tangible Fixed Assets Depreciation Charged In Period
|£ 123
Information about the Private Limited Company SCOTT FURNISHING LIMITED has been prepared for information purposes only. It is not intended to be nor does it constitute legal advice. This is public information provided by the official company register.


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text:
Aestivation and hypoxia-related events share common silent neuron trafficking processes
The availability of oxygen is a limiting factor for neuronal survival since low levels account not only for the impairment of physiological activities such as sleep-wake cycle, but above all for ischemic-like neurodegenerative disorders. In an attempt to improve our knowledge concerning the type of molecular mechanisms operating during stressful states like those of hypoxic conditions, attention was focused on eventual transcriptional alterations of some key AMPAergic silent neuronal receptor subtypes (GluR1 and GluR2) along with HSPs and HIF-1α during either a normoxic or a hypoxic aestivation of a typical aquatic aestivator, i.e. the lungfish (
The identification of partial nucleotide fragments codifying for both AMPA receptor subtypes in
The distinct transcriptional variations of silent neurons expressing GluR1/2 and HSPs tend to corroborate these factors as determining elements for the physiological success of normoxic and hypoxic aestivation. A distinct switching among these AMPA receptor subtypes during aestivation highlights new potential adaptive strategies operating in key brain regions of the lungfish in relation to oxygen availability. This functional relationship might have therapeutic bearings for hypoxia-related dysfunctions, above all in view of recently identified silent neuron-dependent motor activity ameliorations in mammals.
Among the different environmental factors, oxygen proves to be a very critical element for the maintenance of cerebral homeostatic conditions
Under these conditions, the opening of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor channels not only mediates fast excitatory neurotransmission in many synapses
On this basis, it was our intention to identify a temporal relationship of the expression capacity of the silent neurons GluR1 and/or GluR2 to that of the activation of HIF-1α along with HSP27 and HSP70 under normoxic and hypoxic aestivating conditions of the lungfish. The selection of this fish as our experimental model is based on its adaptive capacity to oxygen deprivation by entering into a quiescent aestivating state. The identification of GluR1 and GluR2 mRNA expression patterns overlapping with the above neuroprotective factors might have potential therapeutic application during hypoxia–dependent neurodegenerative disorders, such as ischemia.
GluR1 and GluR2: Molecular identification and distribution pattern
In this work, the application of specific primers designed on rat heterologs (Figure
Figure 1
Molecular identification of GluR1, GluR2, HSP70, HSP27 and HIF-1α in
Molecular identification of GluR1, GluR2, HSP70, HSP27 and HIF-1α in
Figure 2
GluR1 and GluR2 mRNA expression in FW conditions obtained by
GluR1 and GluR2 mRNA expression in FW conditions obtained by
GluR1 and GluR2 mRNA levels during normoxic and hypoxic aestivation
The discrimination of GluR1/2 expression capacities throughout the various brain regions constituted an essential step towards the recognition of these AMPAergic subtypes as major targets of aestivating conditions. qPCR analysis carried out on the whole brain of the different experimental conditions exhibited a very high three-fold (
Figure 3
GluR1 mRNA expression during normoxic and hypoxic aestivation.
GluR1 mRNA expression during normoxic and hypoxic aestivation. mRNA levels were evaluated in whole brain of FW (white1), 6dAE (black2), 6mAE (vertical striped3), 6dMUD (diagonal striped4) and 6mMUD (grey5) animals by qPCR. (a) The results are expressed as a proportion of the highest value after normalization with respect to β-actin expression levels and represent the means ± s.e.m. of three independent biological replicates. GluR1
As far as GluR2 expressing neurons are concerned, they resulted to be active at a rather short aestivating state, thus accounting for up-regulated mRNA levels as early as 6 days for both normoxic and hypoxic conditions. Indeed, qPCR analysis demonstrated a three-fold (
Figure 4
GluR2 mRNA expression during normoxic and hypoxic aestivation.
GluR2 mRNA expression during normoxic and hypoxic aestivation. mRNA levels were evaluated in whole brain of FW (white1), 6dAE (black2), 6mAE (vertical striped3), 6dMUD (diagonal striped4) and 6mMUD (grey5) animals by qPCR. (a) The results are expressed as a proportion of the highest value after normalization with respect to β-actin levels and represent the means ± s.e.m. of three independent biological replicates. GluR2
mRNA expression of protective factors and TUNEL reaction during normoxic and hypoxic conditions
In a same manner as for AMPA receptor subtypes, even the partial coding sequences for both HSP70 [GenBank: HQ993059] and HSP27 [GenBank: JF262201] as well as for HIF-1α [GenBank: 1457856;
Subsequently, qPCR and
Figure 5
HIF1α and HSP27 mRNA expression during normoxic and hypoxic aestivation.
HIF‒1α and HSP27 mRNA expression during normoxic and hypoxic aestivation. mRNA levels were evaluated in whole brain of FW (white1), 6dAE (black2), 6mAE (vertical striped3), 6dMUD (diagonal striped4) and 6mMUD (grey5) animals by qPCR. (a,d) The results are expressed as a proportion of the highest value after normalization with respect to β-actin levels and represent the means ± s.e.m. of three independent biological replicates. HIF‒1α and HSP27
Figure 6
HSP70 mRNA expression during normoxic and hypoxic aestivation.
HSP70 mRNA expression during normoxic and hypoxic aestivation. mRNA levels were evaluated in whole brain of FW (white1), 6dAE (black2), 6mAE (vertical striped3), 6dMUD (diagonal striped4) and 6mMUD (grey5) animals by qPCR. (a) The results are expressed as a proportion of the highest value after normalization with respect to β-actin levels and represent the means ± s.e.m. of three independent biological replicates. HSP70
As far as mRNA levels of HSP70, which has been shown to be indicative of a long-term hypoxia-related protective measure are concerned, this transcript was expressed under prevalently long normoxic and hypoxic aestivating states with respect to other experimental conditions (Figure
Figure 7
Apoptotic events during normoxic and hypoxic aestivation.
Apoptotic events during normoxic and hypoxic aestivation. TUNEL signals were evaluated in 6dAE (black), 6mAE (vertical striped), 6dMUD (diagonal striped) and 6mMUD (grey) states. At 6mAE state, an evident amount of neuronal fields containing apoptotic cells (TUNEL method, black arrow) was detected in TEL (a), Cb (c) and Te (e) with respect to the representative TUNEL control (f). In the case of 6mMUD condition, TEL (b) and Cb (d) continued to supply an evident TUNEL reaction. Variations in apoptotic cell content (g) were reported as % of apoptotic cells ± s.e.m. with respect to FW and analyzed by ANOVA and Newman Keul's test (a
In this work for the first time, altered transcriptional levels of both AMPAergic receptor subtypes mRNAs occurring concomitantly to elevated expression levels of selective neuroprotective factors during the different aestivating conditions tend to underlie a distinct protection program operating in a similar fashion to those reported for some ischemic disorders
Curiously, both AMPA receptor subtypes were not expressed in the same direction especially during reduced oxygen availability of aestivation in mud and this seems to point to the induction of GluR1/2 as a key step responsible for the consolidation of silent synaptic processes, at least during sleeping states
The results of TUNEL analysis and the concomitant increased HSP70 levels seem to suggest that a specific homeostatic neuronal program involving neurogenesis and apoptotic events are characterizing the different aestivating conditions of
It is worthy to note that during hypoxic aestivating conditions AMPA receptor transcriptional levels were increased, as demonstrated by significant mRNA levels of GluR1 and GluR2 during 6mMUD and 6dMUD states, respectively. Similar receptor variations have been reported during short-term hypoxia for rat hippocampal AMPA receptor complex
These results underlie the crucial role of the expression of the AMPAergic silent neurons (GluR1/R2) during aestivation of
The study was performed on the African lungfish
Lungfishes were exposed to two different type of aestivation and precisely in air (normoxia) and mud (hypoxia) conditions, according to previous studies
For this study, we directed our attention to the expression pattern of the AMPAergic silent neurons (GluR1 and GluR2) along with some neuroprotective factors and namely HIF-1α, HSP70 and HSP27 during normoxic and hypoxic aestivation of the lungfish. For this aim, brains of
The specific neuronal fields responsible for the mRNA encoding of GluR1 and GluR2 subtypes as well as for HIF-1α and HSP27/70 in distinct brain nuclei was investigated by performing
The determination of apoptosis was also handled on lungfish brains that belonged to 6dAE (n = 4), 6dMUD (n = 4), 6mAE (n = 4) and 6mMUD (n = 4) with respect to FW (n = 4) by using a kit for immunohistochemical detection and quantification of apoptosis based on TUNEL technology (
The quantification of apoptotic cells (TUNEL) in aestivating animals with respect to FW was performed using a one-way ANOVA followed by a
Ethical standards
Experimental protocols of this study were approved by the National University of Singapore Institutional Animal Care and Use Committee (IACUC Permits 813/05, S06/06 A and 035/09) and by MIUR (Italian University Research Ministry).
AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; Cb: cerebellum; Cc: corpus cerebelli; Dp: dorsal pallium; FW: freshwater controls; HSPs: heat shock proteins; HIF-1α: hypoxia-inducible factor-1 alpha; Hyd: dorsal hypothalamus; HTH: hypothalamus; Hyv: ventral thalamus; In: intercalate nucleus; Lp: lateral pallium; OD: optical density; Pl: lateral portion of medial pallium; Pd: dorsal portion of medial pallium; Pv: ventral portion of medial pallium; Ri: pars intermedia of reticular nucleus; Sl: lateral subpallium; Sm: medial subpallium; Te: optic tectum; TEL: telencephalon; Thd: dorsal thalamus; Thv: ventral thalamus; 6dAE: 6 days of aerial normoxic aestivation; 6mAE: 6 months of aerial normoxic aestivation; 6dMUD: 6 days of mud hypoxic aestivation; 6mMUD: 6 months of mud hypoxic aestivation.
Competing interests
The authors declare that they have no-financial competing interests in relation to this MS.
Author's contributions
GG design the study, carried out molecular studies, data analysis and drafted the MS; MZ participated in sequence alignment and data analysis; RMF participated in design of the study and statistical analysis; SFC and YKI participated in the design of study and in initial experiments on animal treatment and aestivating conditions; MC participated in design and coordination of the study and cooperated in the draft and final revision of the MS. All authors read and approved the final manuscript.
This study was co-financed by MIUR (Italian University Research Ministry) and by research grant (R-154-000-429-112) awarded by the Singapore Ministry of Education to Y.K. Ip.
Anoxia tolerant brains
Adaptive responses of vertebrate neurons to hypoxia
Clinical perspectives: neuroprotection lessons from hypoxia-tolerant organisms
Lungfish aestivating activities are locked in distinct encephalic γ-aminobutyric acid type A receptor α subunits
Five tropical air-breathing fishes, six different strategies to defend against ammonia toxicity on land
Effects of hypoxia on the energy status and nitrogen metabolism of African lungfish during aestivation in a mucus cocoon
Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
Glutamate receptors in the mammalian central nervous system
Pathophysiology of an hypoxic-ischemic insult during the perinatal period
Calcium: a role for neuroprotection and sustained adaptation
Ischemic cell death in brain neurons
Acute stress induces contrasting changes in AMPA receptor subunit phosphorylation within the prefrontal cortex, amygdala and hippocampus
Hypoxia-inducible factor 1: a new hope to conteract neurodegeneration?
The function of GluR1 and GluR2 in cerebellar and hippocampal LTP and LTD is regulated by interplay of phosphorylation and O-GlcNAc modification
Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke
HIF-1alpha and -2alpha genes in a hypoxia-sensitive teleost speciesMegalobrama amblycephala: cDNA cloning, expression and different responses to hypoxia
The role and regulation of hypoxia-inducible factor-1 alpha expression in brain development and neonatal hypoxic-ischemic brain injury
Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models
Chaperoning brain degeneration
Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
Heat-shock protein (Hsp70) protects glutamatergic synaptic transmission in cells of the rat olfactory cortex against acute anoxia in vitro
Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats
Association of heat shock proteins and neuronal membrane components with lipid rafts from the rat brain
Roles of molecular chaperones in the nervous system
Ca2 + −permeable AMPA receptors in synaptic plasticity and neuronal death
Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites
Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons
Upregulation of GluR2 decreases intracellular Ca2+ following ischemia in developing gerbils
The enigma of aestivation in the African lungfish Protopterus dolloi-commentary on the paper by Perry et al
Intracellular calcium and survival of tadpole forebrain cells in anoxia
Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy
Nitrogen metabolism in the African lungfish (Protopterus dolloi) aestivating in a mucus cocoon on land
Cell death in health and disease
The AMPAR subunit GluR2: still front and center-stage
Sleep function and synaptic homeostasis
Identifications, classification, and evolution of vertebrate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit genes
cDNA cloning of chick brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors reveals conservation of structure, function and post-transcriptional processes with mammalian receptors
The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
Mammalian cerebral metabolism and amino acid neuro-transmission during hibernation
Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region specific gene targeting
Glutamate drives the touch response through a rostral loop in the spinal cord of zebrafish embryos
Cell proliferation and death in the brain of active and hibernating frogs
Synaptic protein dynamics in hibernation
Adult neurogenesis and neuronal regeneration in the brain of teleost fish
Combined effect of tumor necrosis factor (TNF)-alpha and heat shock protein (HSP)-70 in reducing apoptotic injury in hypoxia: a cell culture study.
Localization of the heat-Shock protein Hsp70 to the synapse following hyperthermic stress in the brain
Many mechanisms for hsp70 protection from cerebral ischemia
Glutamate receptor changes associated with transient anoxia/hypoglycaemia in hippocampal slice cultures
Distinct α subunits of the GABAA receptor are responsible for early hippocampal silent neuron-related activities
Remodeling of hippocampal synaptic networks by a brief anoxia-hypoglycemia
AMPA receptors undergo channel arrest in the anoxic turtle cortex
Effects of hypoxia on stress proteins in the piglet brain at the birth
Up-regulation of heat shock protein HSP20 in the hippocampus as an early response to hypoxia of the newborn
Heat shock protein 27 delays Ca2+-induced cell death in a caspase-dependent and -independent manner in rat retinal ganglion cells
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depressionin sleep
Brain ischemia and reperfusion: molecular mechanisms of neuronal injury
Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury andin posttraumatic epilepsy
Pharmacological and genetic accumulation of hypoxia-inducible factor 1alpha enhances excitatory synaptictransmission in hippocampal neurons through the production of vascular endothelial growth factor
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions.
Analysis of relative gene expression data using real-time quantitative PCR and the 2(− Delta Delta C(T)) Method
The histaminergic signaling system exerts a neuroprotective role against neurodegenerative-induced processes in the hamster
Immunocytochemical localization of somatostatin and autoradiographic distribution of somatostatin binding sites in the brain of the African lungfish,Protopterus annectens


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This is the 2014 Ford F-150 Tremor, FoMoCo's first-ever EcoBoost-powered sport truck capable to deliver V8 performances with V6 fuel economy. As you can see from the photos, the F-150 Tremor is a short-wheelbase, regular-cab pickup truck that features the FX Appearance Package. Moreocer, the new truck comes with launch-optimized 4.10 rear axle – the shortest final drive ratio offered in an EcoBoost F-150 – helping provide customers with fast acceleration.
Regarding the design, F-150 Tremor comes with stealthy, flat-black accents such as 20-inch flat-black wheels, stylized bodyside graphics as well as black badges with red lettering. As we said, the 2014 Ford F-150 Tremor is powered by a 3.5-liter EcoBoost engine with a maximum output of 365 horsepower at 5,000 rpm on regular fuel and 420 lb.-ft. of torque at 2,500 rpm.
Ford says that up to 90 percent peak torque available from 1,700 rpm to 5,000 rpm. As standard, the F-150 Tremor comes with an electronic locking rear differential that's standard for both two- and four-wheel-drive versions. Connectivity comes standard with the MyFord Touch powered by SYNC.


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Building in Warringah? Here are the plans, policies and laws you need to know.
Decisions about development in Warringah are influenced by state and local planning legislation, strategies, controls and policies designed to address a variety of specific planning issues.
The major items of legislation affecting development in Warringah are the Environmental Planning and Assessment Act, 1979, the State Environmental Planning Policies, the Warringah Local Environmental Plan LEP) and the Warringah Development Control Plan (DCP).
There are also a number of plans and policies designed to address specific issues in Warringah. Those include bushfire-prone land and waterways management.
Local Environmental Plan (LEP) 2011
The LEP is designed to make planning decisions in Warringah consistent with State legislation while allowing for local requirements. The LEP 2011 is based on a system of zones that are differentiated by the range of permitted and prohibited land uses.
Local Environmental Plan (LEP) 2000
Although it has been replaced by the LEP 2011, the LEP 2000 still applies to land known as a 'deferred matter' within Warringah.
Development Control Plan (DCP)
The DCP contains planning controls not included in LEP 2011. The DCP contains detailed local planning controls which support the LEP. The two documents should be read together.
Deferred matter
This refers to land in Warringah that has been 'deferred' by the State Government. This means it is excluded from the area covered by LEP 2011. The affected land lies in the B2 Oxford Falls Valley and C8 Belrose North localities. This land will remain covered by LEP 2000 until further notice. Current DCP controls do not apply to land identified as a deferred matter.
State Environmental Planning Policies (SEPPs)
Certain building projects must be considered under the State Environmental Planning Policies (SEPPs). Some may be approved under particular SEPPs, such as exempt and complying development.


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Because if it did, we're looking at a relatively rosy picture for the economy this time next year.
The yield curve is typically trotted out to predict recessions, and it took a lot of hits in 2006-07 when it was inverted, with many saying that long-term interest rates were being held down artificially by demand from China. Those naysayers have since been proven wrong.
But the curve works pretty well in forecasting growth too, Joseph G. Haubrich and Kent Cherny of the Cleveland Fed remind us. The following chart from the pair shows the spread between 10-year Treasury notes and the 3-month T-bill against GDP growth lagged one year. Since the yield curve is used to forecast growth 2 to 6 quarters out, the lag helps to line up growth levels with the spreads that predict it:
At yesterday's close, the spread between the 10-year and the 3-month was 3.28 percent, down from a peak of 3.82 on October 15. All of the other times the curve was that steep the economy was growing strongly a year later.
But we're living in unique times. A flight to quality has pushed down the yield on the 3-month bill, so the argument could be made that the curve should really be a little flatter. Plus, if bank lending doesn't pick up, the scenario for robust growth late next year seems quite dismal. And looking at Japan's experience after its bust doesn't provide confidence. In the mid-1990's, the similar spread between 10-year and 3-month Japanese government debt was relatively high, but tepid growth and recession followed.
On the other hand, Haubrich and Cherny say the chance the economy will be in a recession late in '09 is a tiny 0.05 percent. And after the super-gloomy FOMC statement yesterday afternoon, a little optimism doesn't hurt.


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Trying to wrap one's head around the buying power of a dollar in different time periods is never easy:
Determining the relative value of an amount of money in one year compared to another is more complicated than it seems at first. There is no single "correct" measure, and economic historians use one or more different series depending on the context of the question.
Most indices are measured as the price of a "bundle" of goods and services that a representative group buys or earns. Over time the bundle changes; for example, carriages are replaced with automobiles, and new goods and services are created such as cellular phones and heart transplants.
These considerations do not stop the fascination with these comparisons or even the necessity for them. For example, such comparisons may be critical to determine appropriate levels of compensation in a legal case that has been deferred. The context of the question, however, may lead to a preferable measure and that measure may not be the Consumer Price Index (CPI), which is used far too often without thought to its consequences.
The example below of what Babe Ruth's salary was "worth" can demonstrate this point. His earnings had a "purchasing power" in today's price of a million dollars, but he could not purchase any effective cure for cancer. However, if the question was how to compare his salary with that of a current super star such as Tiger Woods or Barry Bonds, using Ruth's wage compared to an unskilled worker, the average income or the percent of Gross Domestic Product (GDP) he earned gives comparable numbers."What is its Relative Value in U.S. Dollars" from the Economic History Services
So let's put it in context by considering one of the most famous ad jingles (listen) of all time. That would be the 1939 ad from Pepsi-Cola touting the benefits of their "superior" formulation of sugar water:
At about the same time Pepsi-Cola launched what was to become one of the most famous jingles ever written. "Nickle, Nickle" (later known as "Pepsi-Cola Hits the Spot") was written by Alan Bradley Kent and Austen Herbert Croom-Johnson.
Pepsi-Cola hits the spot
Twelve full ounces, that's a lot
Twice as much for a nickle, too
Pepsi-Cola is the drink for you.
This little jingle would go on to be recorded in 55 different languages, over 1 million records containing this jingle were produced, and it was the first jingle ever played from coast to coast on network radio. It is hard to convey just how big this jingle was, but it was very popular for nearly a decade and was even described as "immortal." How many people decided to give Pepsi a try because of this jingle can not be over estimated. The jingle was first written as a standard commercial with the jingle at the end but Mack insisted that only the jingle be aired. It was played so often that 50 years later there are still people who remember the words.The History of Pepsi-Cola, Soda Museum
Now, let's consider what the "Twice as much for a nickle, too" means in today's dollars: (BTW: the "twice as much" referred to Pepsi-Cola's twelve ounces versus Coca Cola's six.)
In 2003, $0.05 from 1940 is worth:
$0.65 using the Consumer Price Index5 cents scaled from 1940 dollars to 2003 dollars
$0.54 using the GDP deflator
$1.39 using the unskilled wage
$2.46 using the GDP per capita
$5.42 using the relative share of GDP
And $0.65 is just about what it would cost you to buy a soda today at a supermarket. (Not quantity one in a bodega, of course.) Notice how the CPI is spot on. Yet not everthing scales so nicely. Consider today's value for a home purchased for $50,000 in 1970:
In 2003, $50,000.00 from 1970 is worth:
$237,137.93 using the Consumer Price Index$50,000 scaled from 1970 dollars to 2003 dollars
$191,863.42 using the GDP deflator
$248,964.68 using the unskilled wage
$373,282.77 using the GDP per capita
$528,834.86 using the relative share of GDP
Inflation in real estate better tracks the change in Gross Domestic Product (GDP) per capita than it does changes in the CPI or wages. That's why a home that was affordable in 1970 requires three salaries to pay for in 2005. That's likely because commodities benefit from improvements in supply and manufacturing not to forget competition, which keep the price down. Real commodities, however, tend to be priced according to the owner's share in the American Dream, aka GDP. What? Your share of GDP hasn't kept pace? Well, that's all the fault of the tax-and-spend Democrats; all the "fiscally-conservative" Republicans got their share of GDP, now didn't they.
Buy land, 'cause they ain't makin' it no more.
— Will Rogers
Sources and Further Reading
- "What is its Relative Value in U.S. Dollars" from the Economic History Services
- "How Much is That" from the Economic History Services
Posted by Citizen Arcane on January 20th, 2005
Categories: Advertising & Marketing, Economics, Food & Drink, History, Reference
Permalink | Comments Off


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26 Re: Municiple Waste declares war on all Disturbed fan's on Fri 29 May 2009, 21:26
What good is it to stoop to their level? We can start a petition to boycott them.
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LEAGUE CITY, Texas (AP) — Some Galveston County residents getting federal housing assistance after being displaced by Hurricane Ike are worried they could soon be evicted because their rents aren't being paid.
SAN ANTONIO (AP) — Buffalo wings for the big game were nearly as unlawful as they are unhealthy for one Super Bowl fan.
GONZALES, Texas (AP) — Jury selection is under way in the South Texas trial of a couple accused of starving their 8-year-old adopted daughter to death.


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text:
|Season 2, Episode 13
General Information
|Air date
|23 May 2014
|Written by
|Steve Lightfoot, Bryan Fuller
|Directed by
|David Slade
Episode guide
|Hannibal(2013) episodes
Jack confronts Hannibal for his crimes.
Plot Summary
After a day of plotting with Jack, Will returns home to find the illusion of Garrett Jacob Hobbs. The illusion tells Will to shoot at the black stag in the forest. Will takes aim and fires. At Bella Crawford's bedside, she is visited by Hannibal. Bella, who is suffering from her cancer, asks Hannibal to save Jack after she passes on.
Over in an FBI safe house, Freddie tells Will about how she will gain respect in her field after publishing their story. Will gives Freddie permission to publish any details, but on the condition that she exclude Abigail in her story. Will leaves Freddie to see Hannibal. The two begin to burn Hannibal's notes on all his patients so they would leave no records behind. As they take on this task, Hannibal catches the scent of Freddie's perfume. as they sit for diner, Hannibal tests Will's loyalty by asking if they need to reveal himself to Will and instead offers to leave with just a note behind. Will, who is trying to trap Hannibal, tells him that he must face Jack.
FBI agent Kade Prurnell discovers Will and Jack's plan to capture Hannibal in the act. She tells them that they will never convince a court to capture Hannibal because they are goading Hannibal into killing. She order Jack to leave his badge and gun. After Jack leaves she calls a warrant on Will and Jack for the murder of Randall. Alana warns Will about the pending arrest. Will, in turn, grabs his gun and warns Hannibal.
Jack meets Hannibal in the kitchen for their confrontation. After a brief greeting, the two fight to the death. After a prolonged struggle, Hannibal lands a fatal stab to Jack's neck with a shard of glass. Jack scurries away behind a pantry as Hannibal pounds the door to finish him off. Then Alana appears with her gun. Hannibal gives her a chance to leave and forget what she saw. Alana takes her chances and attempts to shoot Hannibal only to find out that Hannibal had taken her bullets. She then runs upstairs to get away from Hannibal. Suddenly, she finds Abigail, who pushes Alana out the window. Will arrives as Alana lies dying on the ground. Upon hearing that Jack is in trouble, he is forced to go inside to save him.
When inside the building, Will finds Abigail and Hannibal together. Hannibal stabs Will with a knife. Hannibal laments that Will had betrayed him since he had a deep connection with Will. In retaliation for his betrayal, he cuts Abigail's neck and leaves the area. He finds Bedelia and the two head off onto a plane.
- Hugh Dancy as Will Graham
- Mads Mikkelsen as Dr. Hannibal Lecter
- Caroline Dhavernas as Dr. Alana Bloom
- Laurence Fishburne as Jack Crawford
- Cynthia Nixon as Kade Prurnell
- Gina Torres as Bella Crawford
- Lara Jean Chorostecki as Freddie Lounds
- Kacey Rohl as Abigail Hobbs
- Vladimir Jon Cubrt as Garret Jacob Hobbs
- Gillian Anderson as Dr. Bedelia Du Maurier
- Jessica Malka as French Stewardess
- After the credits, there is a scene where Hannibal is on a plane with Bedelia Du Maurier.
- Bryan Fuller had planned for Abigail to be flying away with Hannibal at the end after Jack's confrontation.
- Mizumono is a Japanese word for "just desserts."
- Fuller had originally planned for Abigail Hobbs to be the person Jack finds in the well. If Anderson's schedule did not have space for the series, Fuller said that he would have used Abigail in her place as a witness against Hannibal.
- Before it was known that the series was going to be renewed for a third season, there were some concerns that Hannibal was going to be cut from the NBC lineup. In an interview with IGN after the series finale had premiered, Fuller revealed that he had two options if the series had been canceled. He hinted that if Hannibal was canceled, he would have moved the series to a cable network.
- In an interview with Collider.com, Bryan Fuller said that he had created the finale to be open ended so that fans can interpret what would happen if the series did not get picked up for another season.
- Bella Crawford: "Forgiveness is such a profound, conscious, and unconscious state of affairs. You can't actually choose to do it. It simply happens to you."
- Jack Crawford: "Hannibal thinks you're his man, and I think you're mine."
- Hannibal Lector: "I'm dismantling who I was and moving it brick by brick."
- Hannibal Lector: "Love and death are the great hinges in which all human sympathies turn."
- Hannibal Lector: "When the fox hears the rabbit scream he comes running – but not to help."
- Hannibal Lector: "Hello?"
- Will Graham: "They know."
- Hannibal Lector: "He'll try to kill you in the kitchen, out of convenience. Easier to prepare the tar-tar."
- Hannibal Lector: "Fate and circumstance have returned us to this moment, when the teacup shatters. I forgive you, Will. Will you forgive me? "
- Will Graham: "You were supposed to leave."
- Hannibal Lector: "We couldn't leave without you. Time did reverse. The teacup that I shattered did come together. A place was made for Abigail in your world. You understand? A place was made for all of us, together. I wanted to surprise you. And you wanted to surprise me.I let you know me, see me. I gave you a rare gift, but you didn't want it."
- Hannibal Lector: "I gave you a rare gift, and you didn't want it. You would deny me my life. "
- Will Graham: "Not your life."
- Hannibal Lector: "My freedom then, you would take that from me. Confine me to a prison cell. Did you believe you could change me the way I've changed you?"
- Will Graham: "I already did."