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The purpose of this study is to examine the relationship between ultraviolet B and global incidence of colorectal cancer, while controlling for relevant covariates. Linear regression was used to assess the relationship between latitude and incidence rates of colon cancer in 173 countries. Multiple linear regression was employed to investigate the relationship between ultraviolet B dose and colorectal cancer rates while controlling for per capita intake of energy from animal sources, per capita health expenditure, pigmentation, and life expectancy. Data on all variables were available for 139 countries. Incidence of colon cancer was highest in countries distant from the equator (R2 = 0.50, p < 0.0001). UV B dose (p < 0.0001) was independently, inversely associated with incidence rates of colorectal cancer after controlling for intake of energy from animal sources, per capita health expenditure, pigmentation, and life expectancy (R2 for overall model = 0.76, p < 0.0001). Consistent with previous research, UVB was inversely associated with incidence of colon cancer. Further research on vitamin D and prevention of colon cancer in individuals should be conducted, including studies of higher serum 25-hydroxyvitamin D concentrations than have been studied to date.
Colorectal cancer accounts for approximately 1,234,000 cancer cases each year and causes approximately 608,000 deaths each year1 making it the fourth most common cause of cancer death.1 In the United States, there are expected to be 103,000 cases and 50,000 deaths from colon and rectal cancer in 2011.2 About 37,000 of these deaths are thought to have occurred in patients with an original diagnosis of colon cancer. There are several well-established risk factors for colon cancer, such as smoking,3 drinking,4 and red meat.5 However, these risk factors cannot account for all of the excess risk at the population level.
A wide range of studies support the hypothesis that inadequate sunlight exposure and low serum vitamin D metabolite levels may be making a substantial contribution to morbidity and mortality from this disease.6 Colon cancer incidence and mortality rates tend to be higher in areas with low winter sunlight levels, and lower in sunny areas.7 Evidence from epidemiological studies has been mostly supportive. Fifteen case-control studies8 and eight prospective studies9 of serum 25(OH)D concentration or oral vitamin D intake found significant, inverse relationships between vitamin D and colorectal cancer. A meta-analysis of 60 observational studies on dietary intake of vitamin D revealed a 6% reduction in colorectal cancer risk, although this correlation was not statistically significant.10 However, studies of dietary intake of vitamin D, which mostly rely on information obtained from questionnaires, are subject to greater imprecision in exposure assessment than studies of serum 25(OH)D, a biomarker that incorporates vitamin D from all sources.
Exposure of the skin to ultraviolet B (UVB) rays in sunlight is the source of 80% to 95% of circulating vitamin D and its metabolites in humans, so availability and intensity of sunlight are strong correlates of serum 25-hydroxyvitamin D [25(OH)D], the principal circulating vitamin D metabolite.11 Observational studies have shown that serum 25(OH)D concentrations are lower in populations residing at latitudes more distant from the equator, where less UVB irradiance is present.6 Exposure to UVB and supplemental vitamin D3 intake increase serum 25(OH)D levels in a dose-dependent manner.12
Once vitamin D is photosynthesized in the skin by contact with UVB radiation, it is converted in the liver to the main circulating vitamin D metabolite, 25(OH)D.13 Some of the circulating 25(OH)D is further metabolized by the enzyme 1-α-hydroxylase into 1,25 dihydroxyvitamin D [1,25(OH)2D], the most biologically active vitamin D metabolite, although this metabolite is present in the circulation in approximately 1/1000th the concentration of 25(OH)D.13 The principal site of 1,25(OH)2D synthesis is the kidney, but production of the hormone occurs in a wide range of tissue including colonic epithelial tissue,13,14 which has vitamin D receptors that are highly sensitive to 1,25(OH)2D. Moreover, 1,25(OH)2D has been shown to promote differentiation and apoptosis in colon cancer cell lines.
The primary aim of this ecological study was to examine the relationship between UVB, adjusted for cloudiness, and colorectal cancer incidence on global scale, while controlling for possible confounders. This is the first study, to the authors' knowledge, to examine the associations between latitude and UVB dose with global age-standardized colorectal cancer incidence rates, while controlling for covariates.
Age-standardized incidence rates of colorectal cancer were higher at latitudes distant from the equator, with a few exceptions (R2 = 0.50, p < 0.001) (Fig. 1). A dose-response analysis also indicates an inverse association between modeled serum 25(OH)D and incidence rates (Fig. 2). In the multiple linear regression model, UVB adjusted for cloud cover was inversely associated with age-standardized colorectal cancer incidence rates (p = 0.01) (Table 1), after controlling for covariates. In this analysis there was a positive association between per capita animal consumption and colorectal cancer incidence rates (p = 0.0302) confirming results from previous research on risk factors for colorectal cancer (Table 1). The overall model was statistically significant (R2 = 0.76, p < 0.0001) (Table 1).
To the authors' knowledge, this is the first analysis reporting the relationship between incidence rates of colorectal cancer and solar UVB dose while controlling for several covariates relevant to colorectal cancer risk. UVB varies inversely with latitude.16 Countries located at latitudes distant from the equator, where the level of UVB is relatively low, had higher incidence rates than countries located at latitudes closer to the equator (Fig. 1). Colorectal cancer incidence rates may be higher than expected, given their latitudes, for Argentina, Australia, New Zealand, and Uruguay, which are all in the southern hemisphere. Part of the reason for this may be that the earth is farther from the sun in the Austral (southern hemisphere) winter than in the Boreal (northern hemisphere) winter, as Earth's orbit around the sun is mildly elliptic. This results in approximately 7% lower solar dose during winter in the southern hemisphere compared with the northern hemisphere.17
In a multiple linear regression model that included 139 countries, high levels of UVB were significantly, inversely associated with age-standardized incidence rates of colorectal cancer. This relationship may be due to reduced population levels of serum 25(OH)D, the principal circulating vitamin D metabolite, in countries distant from the equator, where UVB is lower.6 In this analysis, intake of energy from animal sources was positively, significantly associated with colorectal cancer incidence, findings which are consistent with previous studies that have identified an association between colorectal cancer risk and consumption of red meat.5 Although this covariate accounts for some of the variation in colorectal cancer incidence rates at the population level, it does not account for all the variation in risk. This suggests that another factor, possibly low vitamin D status, may account for the unexplained excess risk. Although it is possible that some of the association could be due to better surveillance in countries distant from the equator, where incidence from colorectal cancer is highest, the inverse relationship between UVB dose and colorectal cancer incidence was independent of per capita health expenditure.
It is still not completely understood how vitamin D metabolites may prevent colorectal cancer. One possible explanation is that levels of 1,25(OH)2D (the most biologically active vitamin D metabolite) present in colonic epithelial tissue may be increased by higher serum concentrations of 25(OH)D, which serves as substrate for extrarenal synthesis of 1,25(OH)2D. In one study of human colonic tumors, expression of the 1a-hydroxylase enzyme, which converts 25(OH)D into 1,25(OH)2D, was upregulated in cancerous tissue.18 Although most synthesis of 1,25(OH)2D occurs in the kidney and is tightly homeostatically regulated,19 synthesis of 1,25(OH)2D can occur in a wide range of tissues, including the epithelial tissues of the colon.19 1,25(OH)2D has many anticarcinogenic properties such as promoting differentiation, inhibiting tumor cells from recruiting local vasculature20 and inducing apoptosis of epithelial cells in tissue through the decrease of phospho-Akt and phospho-Erk, kinases responsible for the regulation of apoptosis, and through the upregulation of MEKK-1, a proapoptotic signaling molecule.21
A theoretical model has been proposed for the role of vitamin D deficiency in colorectal cancer risk, based on evidence from laboratory and observational studies consisting of the following steps: (1) loss of intercellular adhesion proteins due to the decoupling of epithelial cells; (2) initiation resulting from ionizing radiation, chemical carcinogens, infidelity of DNA reproduction, and, possibly, epigenetic factors; (3) natural selection of rapidly-reproducing clones within a tissue compartment; (4) overgrowth of tumor mass and basement membrane penetration; (5) metastasis to remote tissues; (6) the occurrence of an dormant state; and, finally, (7) transition to permanent dormancy, given the presence of vitamin D.22 Recent studies have shown that the gene products of p53,23 a human tumor suppressor oncogene, and p63,24 the murine analog of p53, can induce vitamin D receptor synthesis, thereby controlling the effect of vitamin D on intercellular adhesion.
There were several strengths to this study. It is the first study, to our knowledge, to analyze incidence rates of colorectal cancer by latitude and UVB dose at widely different latitudes in a large number of countries. The analysis uses multiple linear regression to account for several potential risk factors. This model accounted for 77% of the variation in age-standardized incidence rates for both sexes. Separate multiple linear regression models with the same independent variables were run for males (R2 = 0.72; p < 0.0001) and females (R2 = 0.77; p < 0.0001). These models account for a substantial amount of colorectal cancer incidence rates worldwide. For all models, the independent inverse association of incidence rates with UVB dose persisted after controlling for other variables. These variables, such as per capita health expenditures, pigmentation, life expectancy, and intake of energy from animal sources, were included in order to account for differences between countries on relevant factors also highly correlated with latitude. Furthermore, the proportion of global variation in incidence of colorectal cancer explained by latitude in this study is consistent with other observational studies on the relationship between ultraviolet B dose and risk of several cancers, including those of the colon (R2 = 0.68; p < 0.0001),25 breast (R2 for the model = 0.55, p < 0.0001),25 and ovary (R2 = 0.60, p < 0.0001).26
Although multiple regression was used to control for several confounders, complete data were available for only 139 countries. This may have potentially biased the results of the analysis if countries for which complete data were not available differed importantly from countries for which complete data were available with respect to prevalence of risk factors for colorectal cancer incidence. These exclusions were non-differential, being due to lack of data on all variables for these countries. The majority of the countries with incomplete data were economically poor countries in sub-Saharan Africa and Central Asia. Most of these countries are located close to the equator and experience high levels of UVB and low incidence rates of colorectal cancer. Therefore, under the vitamin D hypothesis, it is possible that the exclusion of these countries may have weakened an ecological association between UVB dose and colorectal cancer incidence. Also, since the excluded countries tended to have lower per capita health expenditure, a bias in favor of detecting the association may have been created.
Although they are the best available data sources, limitations have been described on the measurements for GLOBOCAN incidence rates,1 WHO per capita health expenditures,27 and ISCCP data on cloud cover.28 This study could not account for all differences in diet, behavior, and culture across countries. For example, absorption of UVB by clothing could not be measured in the present study, yet it is possible that the association of UVB with incidence rates of colorectal cancer could have been influenced by the type of clothing worn. Since there was no systematic source of information available on clothing characteristics according to country, it was not possible to examine this possible interaction.
Findings from ecological data may not apply to individuals.16 Ecologic studies such as the present analysis should be considered to be hypothesis-generating, rather than definitive. They may indicate variables which should be investigated in observational studies. However, studying a diverse geographic distribution of populations, as was done in this analysis, allows for a natural experiment on a very large scale. Natural experiments are valuable in that previously unrecognized environmental factors for a disease are identified.
In this analysis, UVB dose, the primary source of circulating 25(OH)D, was inversely associated with colorectal cancer incidence rates globally. The associations observed in this study should be further investigated in observational studies of individuals. New research on the relationship between pre-diagnostic serum 25(OH)D levels, especially at higher concentrations, and colorectal cancer risk in individuals would be especially informative.
A data set was created that contained information for each country on age-standardized incidence rates of colorectal cancer, latitude of the population centroid, UVB dose adjusted for cloudiness, per capita health care expenditure in international dollars, per capita energy intake from animal sources, pigmentation, and life expectancy. Data on all variables were available for 139 countries.
Age-standardized incidence rates of colorectal cancer were obtained for all countries using the International Agency for Research on Cancer (IARC) GLOBOCAN database.1 GLOBOCAN uses national registries and registration of vital events to estimate annual age-standardized incidence rates per 100,000 population in 2008, the latest year for which complete data were available. Incidence rates were age-standardized to the world standard population, using the direct method with five-year age intervals.
The total solar UVB irradiance at the top of the atmosphere on the winter solstice date was calculated using a standard algorithm.29 The total noon solar irradiance at the top of the atmosphere for each country on the date of the winter solstice was calculated using the formula A' = A * cos (x + 23.5 degrees) in the northern hemisphere; and A' = A * cos (x – 23.5 degrees) in the southern hemisphere; where x = latitude of the population centroid of the country in degrees, A = total solar radiation at the equator in W/m2 (i.e., the solar constant, 1366 W/m2), and A' = total solar radiation in W/m2 for the country on the date of the winter solstice.29 Since UVB is approximately 0.4% of total solar irradiance, total solar irradiance was multiplied by 0.004 to obtain the estimated UVB irradiance at the top of the atmosphere. Latitude was determined for the population centroid of each country. Population centroids were calculated by the Columbia University Center for International Earth Science Information Network.30
The cloud cover estimate was based on data from the National Aeronautics and Space Administration (NASA) International Satellite Cloud Climatology Project (ISCCP) satellite28 that provided cloud cover data for areas corresponding to the size of many countries, rather than population centroids. If there were multiple cloud cover percentages for a particular country, the percentage for the most populous region of the country was used. This differed to a minor degree from the procedure for UVB at the top of the atmosphere, which was estimated for the atmosphere above the population centroids. In order to account for the influence of cloud cover on transmission of UVB through the atmosphere, solar UVB at the top of the atmosphere was adjusted for mean cloud cover by multiplying UVB irradiance at the top of the atmosphere by the mean winter percentage of sky that was not covered by clouds for each country. UVB was adjusted for cloudiness by the following formula: UVB irradiance * (1- mean proportion of sky covered by clouds).
Data on life expectancy by country for those born in 2010 were provided by the UN Department of Economic and Social Affairs,31 and data on pigmentation by country was available from published literature.15 In order to control for disparities in access to and quality of healthcare among the different countries included in the analysis, data on per capita health expenditures in 2001 for each country were used in the regression model. This was expressed as the average number of international dollars spent by government on healthcare per citizen.27 International dollars are the equivalent in purchasing power of US dollars. Per capita cigarette consumption was the mean number cigarettes smoked per person per year in 1980.32 Including a time lag was not necessary for solar UVB irradiance at the top of the atmosphere, which does not vary appreciably over time.
Age-standardized incidence rates for 173 countries were obtained from GLOBOCAN1 and plotted by latitude of the population centroid. The best fit to the data points was obtained using a polynomial trend line. Multiple linear regression was employed in order to investigate the relationship between age-standardized incidence rates of colorectal cancer and UVB dose adjusted for cloudiness, per capita health care expenditure, pigmentation, and life expectancy. Data for all covariates were available for 139 of the 173 countries in the GLOBOCAN database, therefore the multiple linear regression model consisted of 139 countries. All analyses were performed using SAS Version 9.3 and JMP Version 10.0.0 (Cary NC: SAS Institute).
Thanks to M. Ferlay and the staff of the International Agency for Research on Cancer, Lyon, France, for providing access to the GLOBOCAN database.
No potential conflicts of interest were disclosed.
This research was supported by a Congressional allocation to the Penn State Cancer Institute of the Hershey Medical Center, Hershey PA, through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126 at the Naval Health Research Center (San Diego, CA). The views expressed in this report are those of the authors and do not represent an offıcial position of the Department of the Navy, Department of Defense, or the US. Government.
Previously published online: www.landesbioscience.com/journals/dermatoendocrinology/article/23773
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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I Saw God Today
How about you? 3 People
Love of GodWe saw love today "Come on" I yelled. Man it is taking forever to get the kid's movin today. It seems like all is in slow motion. We never seem to get up early enough. "Lets Go Ya"ll" breakfast is getting cold and you need to get on the bus...
ladysilver 56-60 0 Nov 4, 2008

subset: commoncrawl


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Sehlerberg rankings
Difficulty ranking world: 4986 (all)
Ranking Germany: 70 (all)
Difficulty score: 52.21 what?
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The Sehlerberg is situated in Baden-Wurttemberg.
Starting from Cochem-Sehl,
the Sehlerberg ascent is 2.17 km long. Over this distance, you climb 245 heightmeters.
The average percentage thus is 11.2 %.
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Sapieha Palace, Vilnius
Sapieha Palace (Lithuanian: Sapiegų rūmai, Polish: Pałac Sapiehów w Wilnie) is a High Baroque palace in Sapiegos str., Antakalnis district of Vilnius, Lithuania. It is the only surviving of several palaces formerly belonging to the Sapieha family in the city.
The palace, ordered by Polish prince and Great Hetman of Lithuania Jan Kazimierz Sapieha the Younger was built in Baroque style in 1691-1697 in the place of former wooden mansion of Lew Sapieha (who died here in 1633). The palace was designed by Giovanni Pietro Perti and decorated with frescos by Michelangelo Palloni. The piano nobile has initially displayed Dutch tiles and mosaics representing blazons, churches, castles, and palaces owned or built by the Sapiehas. Originally, the palace had multi-floor arcades on its sides,[1] which were later built up to gain more space inside the building.
In 1809 the palace was acquired by the Russian government and restructured (according to Józef Poussier's design) into a military hospital in 1843. Much of the rich interior was destroyed throughout the 19th century. The exterior of the palace was restored only in 1927-1928 and the building housed University's ophthalmology institute until World War II. Since the war it has been used as military hospital again and fell into disrepair. Today the complex houses the Sapiega Hospital (Lithuanian: Sapiegos ligoninė).
The palace is surrounded by the remains of the 17th-century formal park, with parterres, ponds, and avenues. The impressive Baroque gate secures the entrance to the park from the Antakalnis street and the other gate is in the opposite side of the park, near the palace. Both of them have been restored in 2012.
Since 2012, the palace has been undergoing restoration, in an attempt to bring it as close as possible to its original Baroque appearance.
See also[edit]
- ^ Kłos, Juliusz (1937). Wilno. Przewodnik Krajoznawczy (in Polish). Wilno. p. 271.
External links[edit]
Coordinates: 54°41′55″N 25°18′50″E / 54.69861°N 25.31389°E


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- Sold for: Start Free Trial or Sign In to see what it's worth.
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- Source: eBay UK
- Sold Date: Aug 17, 2013
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WW1 trio to a Royal Marine. all 3 medals are engraved DEAL 3109-S- PTE .W.HOLDEN.R.M. that chap was in the Royal Marines Medical Unit (RND)all the men with the prefix DEAL and numbers between 3000/S and 4400/S were in the Royal Marines Medical Unit. Posted with eBay Mobile


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Araucaria angustifolia is a tree that belongs to Araucariaceae family and it is mainly found in Southern Brazil. This plant has a notable therapeutical history in folk medicine holding great socioeconomic and environmental importance. Until now, some studies were conducted to assess its chemical composition, biological and pharmacological properties. The studies have shown that the bark, knot, needles (leaves), seeds and bracts (sterile seeds) contain high concentrations of active compounds and exhibit different biological effects. In the folk medicine the different parts of this plant are used to treat various types of illnesses, such as shingles, respiratory tract infections, sexually transmitted diseases and some types of wounds. Bearing this in mind, this review focuses on all currently chemical and biological effects already reported for A. angustifolia and provide a novel perspective and useful information for future research.
Cátia S Branco , Tiago S Rodrigues , Émilin D Lima , Caroline Calloni , Gustavo Scola and Mirian Salvador
All Published work is licensed under a Creative Commons Attribution 4.0 International License
Copyright © 2017 All rights reserved. iMedPub Last revised : July 20, 2017


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Nicholas Scott "Nick" Cannon (born October 8, 1980) is an American actor, comedian, rapper, and radio/television personality. On television, Cannon began as a teenager on All That before going on to host The Nick Cannon Show, Wild 'N Out, and America's Got Talent. He acted in the films Drumline, Love Don't Cost a Thing, and Roll Bounce.
Nick appears as himself on America's Got Talent when Peter performs an audition when he accidentally gets Stewie's harmonica stuck in his rectum in "No Country Club for Old Men".


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Daniel Levine: Unique food selections are always on trend
The trends expert is seeing a rise in unusual food selections
"There are all kinds of food trends buzzing around right now," says Daniel Levine. "There's all-natural, farm-to-table, organic, sustainable, transparent ingredients, healthy choice- the list goes on and on. But while everyone is concerned with how food is husbanded and cultivated, there is also a thriving culture of flavor, creation, and preparation."
Some food ideas aren't particularly unique, but are new to Western culture. For example, bugs are starting to catch on as menu items at hip restaurants in New York and London. Plants are catching on too, with greens like garlic scapes and ramps causing a sensation in the food world. Other unique food ideas are reinterpretations of traditional food items, like pickled green strawberries and the hundreds of interpretations of bacon.
Some ideas, though, are even further out there. The 3-D printing trend has made its way to food, offering consumers the opportunity to eat items like chocolate and pasta straight from a multi-dimensional printer. There is a trend in food fusion, as traditional foods are combined to create hot items like the cronut or the crookie.
"A few years ago, grains like spelt and quinoa were unique and exotic, and now they've reached the mainstream,"
About Daniel Levine
Daniel is a trends expert and keynote speaker who specializes in the latest consumer trends. As trends-spotter who leads a worldwide network of like-minded individuals, Daniel combines observations and experience with analysis to deliver a power message of trends importance to audiences and corporations. Learn more at http://DanielLevine.com
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Casinos Near Lone Star Park at Grand Prairie
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What To Expect
The Penang National Park offers visitors an opportunity to experience many natural facets and habitats. An array of flora and fauna greets visitors along the trails of the tropical rainforest. Apart from monkeys and monitor lizards, migratory birds are frequently sighted at the mangrove swamps and mudflats. There is a high possibility of seeing the green turtles nestling at the sandy beach. This excursion includes a 2-hour soft jungle trek from Teluk Bahang to Pantai Kerachut, and a 20-minute return boat journey. Refreshments provided.
Penang National Park
Jungle trek from Teluk Bahang to Pantai Kerachut
Sightseeing stops as indicated in the itinerary
Qualified English speaking guide
Admission fees
Transportation by air-conditioned vehicle
Return cruise
Meals and drinks unless specified
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Hotel pick-ups are for city center hotels only. For pick-ups outside the city center, additional fees will apply.
Children below 2 years old are free of charge.
Other languages are available on request with additional charge.
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Look, you might think putting together these Best Of categories is a walk in the park. Nah bro, there's levels to this sh*t. It takes time to put this all together, to edit, to put photos together, to edit, get the graphics done and again, to edit and most probably make a bunch of typo mistakes in the process despite editing over and over again. So with all that stress – sometimes you just need some sinful ass unhealthy food to cheer you up and ease that stress.
With that said, Miami's number one outlet for stress-relieving Food Porn is without a question the Pincho Factory. Their menu looks pretty standard upon first glance, but what comes on the plate after you place your order is foodie heaven. Plus, their cojones with some of their menu items puts them on a whole 'notha ball game against the rest of their gastro-factory competitors.
I mean, where in their right minds does it occur for you to put a Pastelito Burger on your brunch menu. We love it. We're talking two Cuban styled pastelitos stuffed with a burger patty, cheese and fried egg(s) and bacon as options. But it doesn't stop there. Every Dominican and Puerto Rican drools at their Tostone Burger. Which is the same concept as the Pastelito Burger, except between two huge ass tostones (but with lettuce, tomatoes and cilantro sauce). The list keeps going with their muh'fuggin Nutella Waffle Sandwich that is pretty much exactly as it reads. What the f**k. If Pincho Factory were a woman, we'd date it and eventually marry it after we got it pregnant (whoa, joke too far for you? chill out, you're reading a Food Porn award category buddy, so you're not exactly in place to be part of the moral police).
Alright, alright you get the point. But top all that off with the simple fact that this year Pincho Factory opened a second location in the Coral Gables area. So you know that they're doing something right. And what's next for them, a Hamburger Burger with burger patties as buns? Seems like it. Get to work on that Pincho!
Pincho Factory
9860 SW 40th St
Miami, FL 33165
Pincho Factory
30 Giralda Ave
Coral Gables, FL 33134


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If organic produce is grown locally, we buy locally. Buying local means within approximately 150 - 200km radius of Toowoomba. Buying local produce ensures fresher produce, getting it from the farmer to the consumer in the shortest time possible, and also selling it to the customer at a cheaper price. Mr Organic has the freshest organic produce in Toowoomba.
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Variation on a traditional Ikat pattern give a fun modern vibe.
Hand Tufted in India
100% wool
Bradford's Collection
1'10"x2'8" Peshawar
Hand knotted in Pakistan
100% Ghazni wool
all natural dyes
1'11"x2'10" Kazak
Hand knotted in Kabul, Afghanistan
100% wool
1'11"x2'7" Hamadan
Hand knotted in Iran
Circa 1940
Natural and synthetic dyes
1'11"x2'8" Mehraban
Hand knotted in Iran, Hamadan Province
Circa 1930
All natural dyes


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Shanola Hampton is an American actress best known for her role as Veronica Fisher in Shameless.
Hampton was born on May 27, 1977, in Charleston, South Carolina, as one of five daughters to a car salesman and an IRS agent. She attended Winthrop University (from which she earned a degree in theater) and the University of Illinois (from which she earned a Masters in Fine Arts in Acting). Moving to Los Angeles, California, Hampton began appearing in commercials in 2001 before starting an acting career. Since then, she has appeared in several TV shows, including Reba, Popular, Scrubs, Criminal Minds, Related, and Miami Medical. She also landed roles in the movies The Mostly Unfabulous Social Life of Ethan Green, The Hanged Man, and You Again. In the summer of 2010, Hampton was cast as a series regular on the Showtime drama-comedy series Shameless as Veronica Fisher, a role for which she has received critical acclaim and has since become her best-known role.
On Criminal MindsEdit
Hampton portrayed Cindi Burns, the cousin of SSA Derek Morgan, in the Season Seven episode The Company.
- Shameless (2011-present) as Veronica Fisher (40 episodes)
- Christmas in the City (2013) as Angie
- They Die by Dawn (2013) as Pretty Woman (short)
- Things Never Said (2013) as Kalindra Stepney
- Hot and Bothered (2012) as Alex (short)
- Criminal Minds - The Company (2012) TV episode - Cindi Burns
- You Again (2010) as Tammy
- Miami Medical (2010) as Nurse Graceffa (6 episodes)
- The Hanged Man (2007) as X-Factor
- More, Patience (2006) as Barista
- Pepper Dennis (2006) as Darcine
- Related (2005-2006) as Flash (5 episodes)
- The Mostly Unfabulous Social Life of Ethan Green (2005) as Charlotte
- Scrubs (2004) as Woman
- Notoriety (2002) as Sarah (short)
- Strong Medicine (2002) as Tracy Saunders
- Electra Woman and Dyna Girl (2001) as Daisy (TV short)
- Reba (2001) as Marci
- Popular (2001) as Girl #1
For an up-to-date filmography, see here.


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Public 74
San Juan Capistrano, CA 92675
- $$
- Patio/Sidewalk Dining, Takeout
- Full bar
- Reservations Accepted
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quick question regarding entering chinese character under windows... how can i type 'nu' with two dots above it when using windows language bar and a US keyboard under windows vista? when i type the pinyin "nu" as in female... i think the language bar is expecting me to type it with two dots above the character in order for it to find the correct character... but, i have no idea how to enter that on a US keyboard...
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Welcome to Franklin
Vision Statement
By the year 2030, the City of Franklin, Virginia will maintain our small city identity, heritage, and beauty while being a regional hub for economic opportunities, top-class education, a job-ready workforce, and balanced housing options.
Coming Up
January 1, 2017
2017 Recycle Calendar Read More
May 18, 2017
We Be Jammin 2017 Read More
September 30, 2017
AN ANNUAL FAMILY CELEBRATION OF THE HISTORY, CULTURE, EDUCATION, HERITAGE AND THE ARTS OF AFRICAN AMERICANS. Read More
News & Announcements
February 24, 2017
Check out the NEW City of Franklin GIS Viewer!! Read More
July 7, 2016
These are new rules that take effective July 1, 2016 Read More
February 4, 2016
The 2015-2025 CIty of Franklin Comprehensive Plan Read More


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Finding Nemo The Seven Archetypes The Hero Marlin Marlin goes to Sydney to save
Nemo after traveling the sea The Mentor Dory Dory sticks with Marlin
throughout his entire journey Gill Gill helps Nemo gain
confidence, and helps him live
on his own The Threshold Guardian Sharks Bruce, Anchor, and Chum slow down Marlin and Dory, but when Bruce smells blood he ends up leading Marlin and Dory to the goggles The Herald Crush Crush shows Marlin how to
be a better dad The Divers capture Nemo to start the adventure, after Nemo touched the "butt" The Divers The Shape Shifter Angler Fish The Angler lures Dory and
Marlin, and starts trying to eat
them, Dory and Marlin
find the mask thanks to the
light, he holds the key to saving
Nemo Gill Gill at first seems selfish, but comes through in the end and sacrificed himself for Nemo to escape Moonfish The Moonfish play games
and tease Marlin, but after
Dory intervenes, the fish
show them the way The Shadow Darla Darla is the devil figure, that is ultimately supposed to kill Nemo, she kills all the fish that she is given by shaking the bag The Tricksters Sharks Bruce, Anchor, and Chum defy common belief by being very friendly, at first they seem scary and will doom Marlin and Dory, but they befriend them The Twelve Stages of the Journey Ordinary World Marlin and Coral are admiring
the view until Coral is eaten
protecting her eggs, one
survives that becomes Nemo Call to Adventure Nemo goes to school and Marlin finds out they are going to the drop off he chases Nemo, Nemo touches the "butt" and is abducted by divers Refusal of the Call Marlin is afraid of the open sea and is in denial that his son was abducted Meeting the Mentor Shortly after Nemo was kidnapped Marlin runs into Dory, Marlin asks her if she has seen a boat and begins to show him the way, Dory forgets what she's doing, eventually they get on the same page and set off for adventure Crossing the Threshold Marlin is in the open, a place he hasn't been since Coral's death Tests, Allies, Enemies The Whale forces Marlin to trust Dory and it pays off
When Marlin and Dory get trapped in the jellyfish, Marlin goes back to save her
When they find the mask, Marlin Dory use teamwork, to read it, Marlin controls the light and Dory reads
When Dory understands what is happening she becomes a friend Crush who teaches Marlin to relax and let Nemo do things on his own
The sharks seem to be enemies at first but we find out that they are friends
Nigel takes Marlin to Nemo
Gil, Bloat, Gurgle, Peach, Deb/Flo, Bubbles, and Jacques befriend Nemo in the fish tank
Darla is the enemy, she kills the fish that are given to her by shaking the bag Approach to the Inmost Cave Marlin and Dory go over the trench and run into a large group of jellyfish, they race out, Marlin gets out successfully but Dory is stung, they wake up on the EAC with turtles
Marlin and Dory are in the Whale and Marlin has to trust Dory to let go of the tongue, his journey seems over until they land in Sydney Ordeal Nigel takes Marlin and Dory to the dentist, they see Nemo trying to escape and fake his death, the three of them think that he's dead, and Nigel puts them back in the ocean Reward Marlin tells Dory to leave, Dory finds Nemo and they both search for Marlin, Marlin and Nemo are reunited The Road Back Marlin tells Nemo that he is sorry for not believing in him, Marlin, Dory, and Nemo are swimming back, Dory gets caught in a net with a school of fish and Nemo goes in to save her and the rest of the fish Resurrection Nemo goes in and tells the fish to swim down, after a successful escape, Nemo is left laying in the ripped net Return Marlin applies everything he has learned on the journey, Dory is friends with Bruce and the Sharks, Squirt and Nemo are friends, and Marlin tells his infamous sea cucumber and mollusk joke
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Finding Nemo
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Nadeem Ramadanon 30 May 2013
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GAITHERSBURG, Md. MedImmune Ventures, an investment group and subsidiary of AstraZeneca, has pitched in with five other groups for a $49.3 million investment into Ambit, a San Diego cancer drug company that is developing small-molecule technology to help treat cancer, according to Web site bizjournals.com.
This latest investment from MedImmune Ventures backs claims by both MedImmune and AstraZeneca that the five-year-old venture arm would remain intact after the British pharmaceutical bought the local company this summer for $15.6 billion.
"We intend to probably increase our investment and, through MedImmune Ventures, expand to small molecules," said AstraZeneca chief executive officer David Brennan in late October at the Mid-Atlantic Bio conference in Bethesda, Md. "I expect over time, we will increase our investment in that space."
Through the deal, which also includes seven current investors, MedImmune's chief executive, David Mott, is one of three new members to join Ambit's eight-person board.


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Shaggy Dog Figurine
Decorating By AnimalGirl91 Updated 13 Jan 2014 , 2:13pm by Dayti
ok guys, how would I acheive this long shaggy look?
The photo is not really big enough to tell how they did it, but I would use an extruder to get long lengths of equally sized strands, and cut to length on the dog.
Quote by @%username% on %date%


text:
y+, Dx+,Dz+ for LES
Dear all,
Could you please tell me what are the restrictions of y+, Dx+ and Dz+ for LES ? Do those restrictions refer to the maximum values or averaged values ?
Thank you very much in advance !
Re: y+, Dx+,Dz+ for LES
For LES, the recommended values for the grid spacing are (in the case where no wall wall is used) :
Medium resolution : Dy+min = 1 Dx+ ~ 70-80 Dz+ ~ 15-20
High resolution : Dx+ ~ 35 Dz+ < 10
Low resolution : Dx+ ~ 155 Dz+ ~ 35-40
Of course these "should" be averaged values...
Alexandre Chatelain
PhD Student - LES of Heat Transfer CEA Grenoble - LEGI/MoST Team FRANCE
Re: y+, Dx+,Dz+ for LES
Dear Alexandre,
Thank you for your reply. Do you have any reference for those criterions ?
With best wishes
|All times are GMT -4. The time now is 17:02.


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After President Obama lauded the Tigers on their 14-0 season that included a 22-19 victory over Oregon in the BCS Championship Game, Chizik said, "Thank you, Mr. President. What an honor and a privilege it obviously is for the whole Auburn Family to be able to stand here in the White House today and really embrace this moment.
"This is not just a great championship team, it has got great character," Chizik said of his Tigers. "It has got great kids who care about communities, they care about service, they care about doing all of the right things.
"What I would like to do today is introduce one of our seniors, which by the way I really want to say a word of appreciation for so many of our seniors that have been spread out. They have moved on with their life and decided to come back today just for this event and it is big for us.
"Kodi Burns, one of the most selfless players we have on our football team, has a special presentation to you from Auburn University," Chizik added.
Kodi Burns presents President Barack Obama with an Auburn jersey.
Burns, who changed positions from quarterback to wide receiver for the good of the team as a junior in 2009 after the coaching staff change, caught a touchdown pass in the BCS Championship game. The senior from Ft. Smith, Ark., said, "Mr. President, on behalf of Auburn football, I want to present you with this helmet as well as your exclusive, Auburn football national championship jersey."
At the end of the ceremony, Obama shook hands with all of the 90 Auburn players who made the trip along with the coaches and support staff, a group of 150 people. He also did a chest bump with Auburn assistant coach Trooper Taylor. The president thanked the Auburn group for taking the time to talk to a Washington, D.C., youth group on their way to the White House on Wednesday.
The Tigers left campus at 7 a.m. on Wednesday and flew to Washington, D.C., for the one day trip via charter airplane from Columbus, Ga., to Reagan National Airport. They toured the Lincoln Memorial and the White House before heading back to Auburn on Wednesday evening.
The president also praised the Tigers for helping with the cleanup of the town of Pleasant Grove, Ala., which was hit hard by the massive April 27 tornado outbreak. The Auburn team was scheduled to be honored at the White House back on April 29th, but the ceremony was postponed until Wednesday because Obama was touring the damage in the state of Alabama caused by the storms the week the ceremony was originally scheduled.
Coach Gene Chizik takes his turn at the podium.
Obama also praised the Tigers for having the teamwork necessary to win the national championship and singled out All-Americans Cameron Newton and Nick Fairley along with several other players for additional praise.
"Of course, I have got to give it to a couple of players who have not got a lot of attention, but did a great job," the president joked. "There is a guy named Cam Newton, who had a pretty good season and went on to win the Heisman Trophy. There is a guy named Fairley, who won the Lombardi Trophy, the top defensive lineman in the nation. This guy is rough, Fairley. You don't want to be tackled by him. You really don't."
As crucial as Cam and Nick were to this team's success, obviously this is a team sport and you only win it with a team that is passionate and dedicated," the president said. "They had help from teammates like freshman, Michael Dyer, who had an incredible 37-yard run on that final drive after everybody, except Michael, thought he had been tackled. Actually that was some good coaching because the folks on the sideline were yelling, 'Get up, get up.'
"Teammates like senior Wes Byrum, who knew he had to knock the winning field goal through for the guys who had been fighting that whole game. And, obviously, Coach. Coach Chizik, in just two seasons, helped the Tigers go from good to great.
"Then there is the Auburn Family, the folks who celebrated at Toomer's Corner no matter what, no matter what the weather was, folks who haven't missed a game in decades and have waited a generation for a feeling like this. I am sure I speak on behalf of the team in saying everybody here has a little piece of that title.
"So I want to congratulate this team once again on a great season," the president said. "I want to thank them for taking the time during this visit to meet with some local kids from D.C. and share a little joy and inspiration.
"One of the things the First Lady is constantly reminding our young people about is that athletics is just not a spectator sport," he said. "Even if you are not going to be a Nick Fairley or a Cam Newton you can still get out there and move. For the players here to send that message to young people is tremendous."
The 2010 Tigers made several impressive comebacks during the season, but the biggest one came during the 28-27 victory over Alabama to close the regular season. Auburn trailed 24-0 in the second quarter before rallying to win.
"That was unbelievable game," Obama said. "I watched that game. I am busy, but I watched that game."
Also attending the ceremony was Auburn native Robert Gibbs, who was formerly the press secondary for Obama, and his son Ethan who posed for a photo with Obama and the team.
A crowd gathered in the East Room of the White House for the ceremony on Wednesday afternoon.
Jay Jacobs, Auburn's athletic director, made the trip and said, "It's a great day for these players. Nobody gave them a chance at the beginning of the year and to be at the White House is really special for these players, coaches and the Auburn Family. It's been great to see so many seniors come back for this special occasion. It's been like a reunion for the team."
Opening the event, Obama said, "Welcome to the White House. And congratulations to the Auburn Tigers. War Eagle. I notice you all brought some Alabama weather up here, too.
"I want to start by recognizing some very proud members of Congress who are here today. Members of Congress delegation, where are you? Here you go, all the Alabama crew right here--Shelby, Sessions, too. They are very proud. All they do is just talk about you all, Alabama and Auburn. I don't know which way they..."
An audience member then yelled "Auburn," and Obama said, "Okay. See?"
The president then said, "And I want to welcome back to the White House--this is a point of personal privilege--the biggest Auburn fan I've ever met my former press secretary Robert Gibbs is in the house along with my main man, Ethan Gibbs, who has inherited the passion for Auburn that his dad had. Look at...Gibbs has his tie and everything. Come on.
"As some of you may know, Gibbs was born in Auburn. His parents worked in the university library so he and his brother grew up watching the Tigers play. So earlier this year when the team was making its run to the championship, Robert was insufferable. He had a little statue of Aubie on his desk. He had his son, Ethan, he and Ethan would roll the trees in front of the yard after a big win so this is a big day for him.
"Now, this visit was originally scheduled to happen a couple of months ago, but two days before this team was supposed to be in Washington the state of Alabama was hit by a series of devastating tornados. So Michelle and I went down with many members of the congressional delegation to meet some of the folks who had lost loved ones, making sure everything possible was being done to help the community get back on its feet. And it was a heartbreaking visit. Coach and I were just talking about you don't understand the devastation until you see it firs thand.
"But what was also inspiring was the amount of strength and generosity that was shown by so many people in the midst of so much tragedy. And that includes the members of this program. Two days after the tornado, almost 70 Auburn coaches, players and athletic department staff--led by Coach--traveled to Pleasant Grove and Cullman to help out with relief efforts.
"And even though one of the toughest-hit areas by the storm was the home of the Crimson Tide, this team knew what we all know in situations like this, which is we're all on the same team. We're all Americans first and foremost, and we've got an obligation to support each other in times of need.
"So I've said before, I will say again, we will continue to stand with the victims of these disasters, whether they're in Tuscaloosa or in Joplin, Mo., which I just visited a couple weeks ago, we're going to do this as long as it takes until families are able to rebuild.
"Now, the reason obviously we're celebrating today is because of a happier moment for the people of Alabama and to congratulate the Tigers for winning their first national title since before I was born. And I'm getting quite a bit of gray hair so that was a long wait for Tigers fans."
Newton said he was glad he broke away from his NFL training to make the trip. "Seeing those guys (his former teammates) was big in my book," he said. "Just to be reunited with these guys and see their faces once again, I'm cherishing every single moment. I can remember a time when I would see them every day and not think much of it, but now seeing them really means something. When we have our kids and look back, we can say we had a chance to visit the White House.
The quarterback said it was a special day being able to meet the president. "It was special. It is something that you look at on TV and you just wish and wonder what that feels like. Now we've been blessed enough to have this opportunity to meet President Obama. The whole experience was incredible."
Josh Bynes, a senior linebacker on the 2010 team, said he was surprised the president mentioned one of his quotes in the speech. "I was shocked and my heart was beating kind of fast," Bynes said. "I was hoping that he would pronounce my last name right. I was worried he was going to call me 'Burns' or something like that. When he got my last name right, I smiled real hard. It was on national TV so I hope everybody in my family saw it."
Bynes, a key player for the Tigers the past three seasons, said, "This was an awesome experience and I'm so glad I decided to come. It was overwhelming to actually see the president in person and to shake his hand. This was probably the one and only time in my life that I will ever be in the White House. It's been an exciting experience and I'm glad I came."