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Correcting for the effects of natural abundance in stable isotope resolved metabolomics experiments involving ultra-high resolution mass spectrometry
Stable isotope tracing with ultra-high resolution Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS) can provide simultaneous determination of hundreds to thousands of metabolite isotopologue species without the need for chromatographic separation. Therefore, this experimental metabolomics methodology may allow the tracing of metabolic pathways starting from stable-isotope-enriched precursors, which can improve our mechanistic understanding of cellular metabolism. However, contributions to the observed intensities arising from the stable isotope's natural abundance must be subtracted (deisotoped) from the raw isotopologue peaks before interpretation. Previously posed deisotoping problems are sidestepped due to the isotopic resolution and identification of individual isotopologue peaks. This peak resolution and identification come from the very high mass resolution and accuracy of FT-ICR-MS and present an analytically solvable deisotoping problem, even in the context of stable-isotope enrichment.
We present both a computationally feasible analytical solution and an algorithm to this newly posed deisotoping problem, which both work with any amount of 13C or 15N stable-isotope enrichment. We demonstrate this algorithm and correct for the effects of 13C natural abundance on a set of raw isotopologue intensities for a specific phosphatidylcholine lipid metabolite derived from a 13C-tracing experiment.
Correction for the effects of 13C natural abundance on a set of raw isotopologue intensities is computationally feasible when the raw isotopologues are isotopically resolved and identified. Such correction makes qualitative interpretation of stable isotope tracing easier and is required before attempting a more rigorous quantitative interpretation of the isotopologue data. The presented implementation is very robust with increasing metabolite size. Error analysis of the algorithm will be straightforward due to low relative error from the implementation itself. Furthermore, the algorithm may serve as an independent quality control measure for a set of observed isotopologue intensities.
Application of mass spectrometry to stable isotope tracing experiments for the elucidation of glucose dates back to at least the early 1980's
The ultra-high resolution capability of Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS) makes it possibility to identify simultaneously hundreds, if not thousands, of metabolites from crude cell extracts without the need for chromatographic separation
Isotopologue identification and quantification of thousands of metabolites in these metabolomic experiments can provide a wealth of data for modeling the flux through metabolic networks. But before isotopologue intensity data can be properly interpreted, the contributions from isotopic natural abundance must be factored out (deisotoped). This is a computationally expensive and analytically intractable problem for data from lower mass resolution spectrometers where individual isotopically-resolved isotopologues cannot be distinguished
Derivation of the analytical solution
Equation 1 represents the relative distribution of carbon isotopologues from natural abundance only, as a sum of multinomial coefficients multiplied by the intensity of IM+0, the theoretically untainted 12C monoisotopic peak. The terms being summed are similar in form to those presented in Snider, 2007. IM+i;NA is the expected intensity of the ith isotopologue peak representing i additional nucleons. NAxC is the fractional natural abundance of the XC isotope. CMax is the number of carbons in the molecule. The multinomial coefficients, derived from the multinomial theorem with 3 variables represent the number of possible isotopomers of identical mass for a molecule with CMax carbons given 3 isotopes of carbon: 12C, 13C, and 14C.
Isotopologue peaks containing 14C are typically not observed, since the isotope is very rare. Moreover, due to the very high mass resolution in FT-ICR-MS histograms, isotopologue peaks representing molecules comprised exclusively of the major isotope of CHONPS elements (expected elements for biological systems) along with 13C, are completely resolved/deconvoluted and identified. Thus, we can ignore the contributions from 14C and from minor isotopes of all other elements excluding carbon. This simplifies the calculation to a
At natural abundance, each peak, IM+i;NA, is directly related to the theoretically untainted 12C monoisotopic peak, IM+0, that has a fractional intensity of 1 when dividing by the sum of isotopologue intensities. However, once 13C is incorporated into the molecule from a labeling source, the calculation of the contributions from natural abundance becomes more complex
Equation 5 shows the full correction as the original isotopologue intensity minus natural abundance contributions based on lower mass untainted isotopologue intensities. Division by the fractional intensity, 1 - BCsum(i), compensates for natural abundance effects that lower the intensity of the given isotopologue. As illustrated in Table
Table 1
Sequential correction of 13C natural abundance effects in a four-carbon example
I M+i = b Value = ( c I M+i;NA - ΣI M+x *B C (x, i))/(1 - B C sum(i))
The example involves a four-carbon molecule with 13C-labeling involving a single carbon 50% of the time. Each row represents a single application (step) of Equation 5. All numbers rounded to three significant figures.
bCorrected isotopologue values. The use of these values in subsequent steps is highlighted in bold.
cContaminated isotopologue values.
Since 15N incorporation can be distinguished from 13C incorporation due to the very high mass resolution in FT-ICR-MS histograms, it takes only a trivial conversion of Equations 3, 4, and 5 to handle labeling in 14N/15N isotopologues. We simply replace NMax for CMax and NA15N for NA13C. However, handling all of the mixed 14N/15N/12C/13C isotopologues that arise from simultaneous 13C and 15N labeling requires a series of two binomial terms multiplied together as shown in Equations 6 and 7. Given the peaks are isotopically resolved, there are CMax * NMax separate observable isotopologues, whose intensities are represented by IM+i, j;NA. The multiplied binomial terms, BC(x, i) * BN(y, j), describe the combined effects from both carbon and nitrogen natural abundance.
A version of each equation in larger fonts is available in Additional file
Additional file 1
Equations. This file contains all equations in Word 2007 format.
Click here for file
Implementation of the algorithm
We implemented Equations 3, 4, and 5 as an iterative algorithm in the Perl programming language [Additional file
Figure 1
Flowchart of 13C natural abundance correction algorithm
Flowchart of 13C natural abundance correction algorithm. Starting with isotopologue intensities and CMax given as input, the algorithm precalculates needed binomial coefficients. Next, the algorithm calculates the corrected intensities and uses them to calculate the natural abundance contaminated intensities. Then the algorithm compares the observed and calculated contaminated intensities and only continues for another iteration if an improvement is made.
Additional file 2
Perl program implementing the algorithm. Perl program implementing the algorithm displayed in a ASCII text file.
Click here for file
Testing the implementation
We created several sets of simulated isotopologues (test sets) with varying levels of 13C-labeling and added the expected contributions (contamination) from 13C natural abundance by solving for IM+i;NA in Equation 5. We then tested the implementation with these test sets. Figure
Figure 2
Simulated 12C/13C isotopologues of 20 carbon metabolite
Simulated 12C/13C isotopologues of 20 carbon metabolite. In all 3 charts, the red bars represent the relative isotopologue intensities with contributions (contamination) from 13C natural abundance. The green bars represent the corrected isotopologue intensities with this contamination removed. Chart A shows the expected isotopologues of a metabolite with no additional 13C-labeling present. Chart B shows the expected isotopologues of a metabolite with equal amounts of 13C-labeling for 8, 10, and 12 carbons. Chart C shows the expected isotopologues of a metabolite with 100% 13C-labeling.
The implementation is also quite efficient even in an interpreted programming language like Perl. 10,000 repetitions of this algorithm for all 3 simulated test sets took only 17 seconds on a single core of an Intel T7200 Core 2 Duo mobile processor with 2GB of RAM and running release 5.3 of the RedHat Enterprise Linux operating system. The implementation is also very accurate. Given the perfect data in these three simulated test sets, the largest error was 4.12 × 10-16 seen in the IM+1 corrected intensity for the test set representing no 13C-labeling (Figure
Application to phosphatidylcholine 34:1 observed isotopologue intensities
Figure 3
12 C/13 C isotopologues of phosphatidylcholine 34:1
12 C/13 C isotopologues of phosphatidylcholine 34:1. Bar chart of 13C natural abundance contaminated (red) and corrected (green) sets of isotopologues. The lipid metabolite contains 34 carbons in the 2 fatty acid chains, 3 carbons in the glycerol, and 5 carbons in the choline head group.
Discussion and Conclusions
Overall, correcting for the effects of natural abundance makes interpretation of isotopologue intensities from stable isotope tracing experiments easier within the context of cellular metabolism. Such a correction is required before using more quantitative methods of interpretation. Since the relative error is virtually zero with perfectly simulated data and the algorithm is very robust with increasing CMax, the accuracy of this correction is really only limited by the error in the isotopologue intensities themselves. Thus, the propagation of data error through this algorithm should be straightforward to analyze and quantify. Moreover, from Equation 5 it is evident that effects from natural abundance significantly link together groups of observed isotopologue intensities. This difference between calculated and observed intensities should be highly sensitive to the error in a set of isotopologue intensities. Therefore, this difference should be usable as an independent check on the quality of the observed set of isotopologue intensities. Such a quality control check would be especially useful when it is not possible or practical to repeat experiments or to determine whether additional experiments are necessary.
Cell Culture and FT-ICR-MS
We separated glycerophospholipids from crude cell extracts derived from MCF7-LCC2 cells in tissue culture after 24 hours of labeling with uniformly labeled 13C-glucose. We analyzed the sample on a hybrid linear ion trap 7T FT-ICR mass spectrometer (Finnigan LTQ FT, Thermo Electron, Bremen, Germany) equipped with a TriVersa NanoMate ion source (Advion BioSciences, Ithaca, NY) as described elsewhere
Authors' contributions
The author derived the analytical solution, implemented the algorithm, tested the implementation, applied the algorithm to the lipid metabolite experimental data, and wrote the manuscript.
Supported in part by NSF EPSCoR grant #EPS-0447479.
I thank Drs. T. W-M. Fan. A.N. Lane and R.M. Higashi for support and helpful discussion.
Tracers in Metabolic Research: Radioisotope and Stable Isotope
Altered regulation of metabolic pathways in human lung cancer discerned by 13 C stable isotope-resolved metabolomics (SIRM)
Isotopomer-based metabolomic analysis by NMR and mass spectrometry
Metabolic flux profiling of Escherichia coli mutants in central carbon metabolism using GC-MS
Structure-based profiling of metabolites and isotopomers by NMR
Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR
Efficient calculation of exact mass isotopic distributions
Correcting mass isotopomer distributions for naturally occurring isotopes
An automated method for the analysis of stable isotope labeling data in proteomics
Automated deconvolution and deisotoping of electrospray mass spectra
Comparison of Methods for Detecting and Deisotoping Weak, High Charge Signals in Data


text:
Engagement in Care: From Cascade to Continuum to Control
Engagement in Care: From Cascade to Continuum to Control
The National HIV/AIDS Strategy and advent of treatment as prevention have brought increased attention from the HIV medical and service provider community to the continuum of HIV care, also known as the "treatment cascade." The HIV care continuum outlines the different steps or stages of HIV care from diagnosis to viral suppression, and explores the prevalence of individuals living with HIV at each stage. More than 50% of persons diagnosed with HIV are not engaged in regular HIV care. In this webinar,
In this webinar, Michael Mugavero, MD, MHSc, discusses the state of engagement in HIV care in the United States and describes individual and population health implications of HIV care engagement. He also discusses approaches that health centers and HIV/AIDS service organizations can take to measure and improve engagement, drawing from research and his experiences at the University of Alabama Birmingham 1917 Clinic.

subset: commoncrawl


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Interim Staffing
Often organizations find themselves with a task that does not require a full time staff member, or they have a time-defined vacancy (often due to family leave) or functions that are ongoing and cannot wait until a staff member can be found. At Alford Executive Search, we understand that your organization needs to continue to function smoothly even when (and often especially when) there are staffing disruptions.
For Interim support, we can often provide an immediate solution, whether from our own team, our Strategic Partners, or our broad network of professionals that can undertake a special project, provide part-time consulting or temporarily fill a critical role so your organization can focus on its mission and overall objectives.
Recent types of positions for which we have provided Interim support, whether as a standalone project or as part of a larger search partnership, include:
- President and CEO / Executive Director
- Chief Financial Officer
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In support of your specific needs, we work with leadership to define the scope and depth of involvement needed, and then serve those needs onsite and/or offsite with a flexible approach that fits your culture and schedule.
The outcome of these engagements varies by need, but overall, our clients share that they not only met the interim/gap need with our expertise, but our team helped them further more goals and projects than anticipated.
If you are interested in exploring an interim staffing partnership for your organization, email us at email@example.com.


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Select your format based upon: 1) how you want to read your book, and 2) compatibility with your reading tool. To learn more about using Bookshare with your device, visit the Help Center.
Here is an overview of the specialized formats that Bookshare offers its members with links that go to the Help Center for more information.
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I believe people have had enough of the Bushes. I just pray they have had enough of the Clintons as well.
While I won't be shocked if the politically tonedeaf GOP decides to coronate him, I cannot see another Bush presidency happening. Smacks too much of a dynasty, and besides, Jeb IMO simply doesn't have the charisma for a national election.


text: NEW YORK ( TheStreet) -- Shares of Trina Solar (NYSE: TSL) have taken a tremendous swing upward. The stock is trading at $8.81 as of 12:05 p.m. ET, 20.7% above Tuesday's closing price of $7.30. Volume is at 5.1 million, two times the daily average of 2.6 million. Trina Solar has a market cap of $556.6 million and is part of the technology sector and electronics industry. Shares are up 9.3% year to date as of the close of trading on Tuesday. Trina Solar Limited, through its subsidiaries, designs, develops, manufactures, and sells photovoltaic (PV) modules worldwide. The company has a P/E ratio of 1.7, below the average electronics industry P/E ratio of 38.9 and below the S&P 500 P/E ratio of 17.7. TheStreet Ratings rates Trina Solar as a hold. The company's strengths can be seen in multiple areas, such as its reasonable valuation levels and largely solid financial position with reasonable debt levels by most measures. However, as a counter to these strengths, we also find weaknesses including deteriorating net income, poor profit margins and disappointing return on equity. You can view the full Trina Solar Ratings Report. See our top % gaining stocks list for other stocks that are soaring today, or get investment ideas from our investment research center. Interested in other stocks that are soaring? Get free SMS text alerts sent to you when the action happens by texting SOAR to 95370 or select from multiple alert options.


text:
I always hear stories about kids and teens with Autism but they just never seem to compare to our life. My son is almost 16 and is still non verbal with so many behaviroal issues it's unbelievable. He has sensory integration disorder, severe anxiety, OCD, severe hyperactivity, sleep problems, gastrointestinal problems, eating issues, allergies, you name it. There are really no qualified doctors in our area who can help with all of his needs and issues. Everyone with knowledge of Autism lives far away from where we are. Considering it is now 1 in 80 in Colorado for Autism diagnosis, it's extremely disheartening that there are still not nearly enough resources out there especially for older children. The Autism schools and therapists all are concentrating on early intervention (young children) which means the older children and adults often get the shaft.
Are there any other parents out there in a similar position as we are? Are there other parents of children with Autism who feel the same as I do? I feel like I am really the only one who cannot seem to get the sufficient services even though we have accessed dozens and dozens ever since he was diagnosed in 2000.
Hi. I just started working with a young boy and I live in Ithaca, NY. THis school district works daily to support parents and children diagnosed with Autism.
We also have the Fransiska Racker Centers and Unity House programs available that may have support they can offer to you, or ideas.
My school gives me many professionals to help.
Wishing you good luck.


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August 25, 20148:53pm
A CHINESE market for medical technology used to be on the long list of lofty goals for device makers.
NOW med-tech firms are seeing double-digit growth as they partner with Chinese manufacturers, purchase Chinese companies, and race to educate and woo Chinese doctors and patients eager to tap the latest technology.
Originally published as Med-tech industry is booming in China


text:
An ideal reference mic for measuring frequency response and sound pressure levels.
The Beyerdynamic MM 1 is a measurement microphone designed specifically for measuring sound reinforcement and PA systems. It is designed to work with spectrum analyzers for measuring frequency response and sound pressure levels of loud speaker systems. The MM 1 is the ideal microphone for the measurements of audio signals in the research, development, for reverberation testing and other applications.
The MM 1 mic's narrow tubular construction ensures that the microphone has negligible influence on the sound field so that an increase in pressure level is avoided due to the linear frequency response.
Requires phantom power.
- Linear frequency response
- Omnidirectional polar pattern
- Calibrated open circuit voltage
- Narrow tubular construction
MM 1 Measurement Microphone Specifications:
- Transducer type: Condenser (back electret)
Operating principle: Pressure
Polar pattern: Omnidirectional, diffuse field calibrated
Open circuit voltage at 1 kHz (0dB = 1V/Pa) : 15 mV/Pa (_ -36.5 dBV) ± 1 dB
Nominal impedance: 330 Ohms
Load impedance: ? 2.2 k Ohms
Connector: 3-pin XLR
Length: 133 mm
Shaft diameter: 19 mm
Head diameter: 9 mm
Weight without cable: 88 g
Frequency response: 20 - 20,000 Hz (50 - 16,000 Hz ± 1.5 dB)
Max. SPL at 1 kHz: 128 dB
S/N ratio rel. to 1 Pa: > 57 dB
A-weighted equivalent SPL: approx. 28 dB(A)
Power supply: 12 - 48 V phantom power
Current consumption: approx. 3.4 mA


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Nineteen College Girls 53Favorites [+]
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Vote 2011: Labour to dictate terms of government deal
Labour say they expect to be in government in Cardiff Bay by the end of next week.
It is likely they will initially govern as a single party, rather than rush a deal with Plaid Cymru or the Liberal Democrats.
Labour AM Leighton Andrews said they would dictate the terms of any deal.
Welsh Lib Dem leader Kirsty Williams called for a "stable government" as the Tories announced Paul Davies as their new interim leader in the assembly.
Mr Andrews told BBC Wales Labour were the clear winners of the election, meaning they were in a position to take stock and decide the way forward.
"Labour is going to form the government in due course and what shape that government takes will be a matter for the first minister," he told BBC Radio Wales.
"I'm not ruling out going it alone and nor is the first minister - we need to look at what we can do as the Labour party in the short term and over the five year period now that we have the 30 seats."
The newly-elected Plaid Cymru AM Simon Thomas said his party were still open to a repeat of the One Wales coalition with Labour, but they needed to learn the lessons of their disappointing election performance.
He added: "Labour are in a position where they dictate the way forward and I think it's important Plaid takes stock of that and we realise we're not in the position we hoped for in terms of trying to arrange an alternative government or a different way of doing the coalition.
"We are now the third party in Wales and we have to acknowledge that. "We have to look at what is being offered by Labour and look at ourselves and lick our wounds."
Labour are very clearly in the driving seat on 30 seats. The options are all with them.
They can let things breathe awhile. They can just run the show by themselves. But then they've been dropping all these hints about a Labour-led government.
They might choose to strike some sort of informal agreement with the Lib Dems or with Plaid.
They might choose just to keep things going awhile and let those parties have a look at where they are at, how things went, sort one or two things out maybe, and then talk to them.
They might want to give the Lib Dems a good kicking in the next local elections and then do some sort of deal.
The truth is there are any number of options and I don't think we should start double-guessing too early.
Maybe they are toying with us with all these hints about a Labour-led government.
But you can be quite sure that they want to be certain that Carwyn Jones is the first minister and he's getting on with the job and so are they.
The Liberal Democrats are also discussing their next move this weekend. Retaining five out of six seats in Wales is being seen as a positive result given the UK political context.
Kirsty Williams said: "We want there to be a stable government over the next five years and we want to concentrate on the issues we've been campaigning on, how can we strengthen the Welsh economy, how can we improve education results for our children and how can we cut waiting times.
"Whether that's part of government or opposition these will continue to be the main thrust of the work of the Welsh Liberal Democrats."
Meanwhile, Welsh Conservatives will begin the process of electing a new leader on Wednesday, after Nick Bourne lost his seat, ironically because of the party's strong performance in Mid and West Wales.
Until that appointment is decided Preseli Pembrokeshire AM Paul Davies is their interim leader.
Critical areas
The new assembly is likely to meet for the first time next week. Once a new presiding officer and deputy have been elected, there will then be a vote to install a new first minister.
The Conservatives, Plaid and Liberal Democrats are likely to abstain, meaning Carwyn Jones will be elected easily with Labour's votes.
Turnout at Thursday's election was down slightly on the 2007 figure, with 41.6% in the constituency count and 42.2% in the regional list count.
Meanwhile, the Welsh business sector called for "action" in forming a new assembly government.
Robert Lloyd Griffiths, director of the Institute of Directors in Wales, said the critical areas of infrastructure, skills and education needed to be addressed.
CBI Wales director David Rosser said the new government needed to forge a closer relationship with business than ever before because only the private sector could deliver economic growth for Wales.


text:
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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Some help with integration to google spreadsheetsAsked by DormsDirect on June 07, 2013 at 02:13 PM
We have correctly integrated a form to google spreadsheets. We have not edited the form since the creatiion of the spreadsheet, but the spreadsheet is no longer updating when new submissions are made. Is there a reason for this?
Have you edited your Google spreadsheet? Please remove the current integration and re-integrate your form with google spreadsheet.
Please let us know if that resolves your issue.
That doesn't seem to solve the problem. We have removed/reintegrated numberous times now. Each time we reintegrate it creates a new sheet with all the previous submissions to date. However, each time a new form is submitted AFTER we have reintegrated, the new submission is not automatically pushed into the google spreadsheet.
At this time, we have made NO edits to the google spreadsheet (even though eventually we would like to have that functionality). Any suggestions?
*Also, we TOTALLY love your form builder, and we plan on upgrading to your paid services once we can resolve these issues :)
Request you to please let us know the form ID in question so that we can have a look. We will test it and if required will forward your issue to our development team.
The Form name is DD Reservation Form
JotForm Support
This is due to the starting numbers on your form labels e.g. 32" HD Flatscreen. Note that there's some limitations on the API which possibly breaks the integration when a number is positioned on the first place. I would suggest to move these after the text labels instead. Example:
I have cloned your form here and did this, it works after integrating the form to GSpreadsheet.
Cloned Form: http://form.jotformpro.com/form/31583838900964?
Spreadsheet: https://docs.google.com/spreadsheet/ccc?key=0AsdV9QbdAmEtdFJHcW5ValBLczBjLU5pQ3FvczZyV2c#gid=0
Feel free to submit a test.
Hope this helps. Thanks!
That totally fixed the problem! THANK YOU SO MUCH FOR YOUR AMAZING CUSTOMER SUPPORT!!!!
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Royale slider fullscreen background
I am using the royale slider theme which allows a fullscreen background slider on each page. I only want this for the first page, but would like to add a text box on there that only takes up a small bit of the page, not the content box provided in the templates because it takes up the whole screen and obscures my images. I think this is possible with custom fields, but I'm really not sure where to begin or how to add a css class to the stlysheet. I can change css properties, but when it comes to custom fields etc, I am lost!
Can anyone advise me? The site is http://www.vandermeer-paxos.com
Many thanks,
- The topic 'Royale slider fullscreen background' is closed to new replies.


text:
Peek-A-Boo Dirty & Clean Organizers by Sugar Booger (Pink) - Please note that the baby on the Clean organizer is very light pink while the baby on the Dirty organizer is white so you don't get them confused. 14" X 10". Washing instructions: Cold water and tumble dry low.
Average Price: $15.95


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Download GP News & Weather AdFree 2016 apk 2.492 free for Android smartphone
Posted by Xclusion media in Sports | July 9, 2016 | 2 Comments
Apk file size: 15.0 MB
The best F1 app for android is here! Check out GP News & Weather!
This is the no ads version of Formula 1 GP News & Weather app. By purchasing this version you support further development of the application! If you're not sure you can try the ad supported version.
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Get a quick overview of what's coming for the next Formula 1 Grand Prix! Detailed weather forecasts and a quick event timetable in your own time zone!
## Track Info & Statistics ##
Want more information about a Grand Prix? We got you covered! Extended time table, Circuit details, Last year's results, weather conditions and pit-stop strategies and much more!
## TeamStream LIVE ##
Get live updates directly from the teams! Live during a session you'll get inside information about the drivers, mechanical failures, pit-stop strategies and more!
What makes TeamStream so amazing is that it's not only available during a race session! You can follow the teams 24 hours a day, 7 days a week!
With TeamStream you are always the first to know!
## Formula 1 News ##
GP News & Weather has the most Formula 1 related articles in comparison to every other F1 app. We deliver news from around the globe, in your own language!
Want only news written in Dutch? We got you covered! Or maybe only articles from France? We got you covered!
## Get notified and stay updated! ##
Never miss a session again! GP News & Weather reminds you when a session is about to start so you don't miss any of them!
Not around a television to watch live? No problem, just patch in to the TeamStream! We'll also notify you when the session results are available! From the Results panel you can check out any results of the past 10 years (for some GP's even further back)!
## Take a look ahead ##
Want to look further than the upcoming race? The full season calendar will take care of that!
Press any of the Grand Prix' to see the full time table, circuit information and previous results!
## Weather information? ##
Yes, we've got weather information for you. How about a detailed weather history of a Grand Prix? What's the weather trend for the German Grand Prix of the past 10 years? Can we expect warm weather, or freezing temperatures?
Or take a look from beyond the clouds! Get a satellite view of the skies and know when and where the rain is going to hit! With the weather radar you're on top of it!
Unlike other apps, all weather forecasts are for the exact time of the event, not the entire day! And pinpointed on the exact location of the track not the entire city or region!
## Anything else? ##
How about an Italian interface, of French? GP News & Weather comes with 6 interface languages! You can easily select an English, Dutch, French, German, Italian of Spanish interface!
## Got curious? ##
GP News & Weather is a complete F1 Experience in a small package!
What are you waiting for? Check it out!
Updated very frequently, so if you encounter any issues please contact me at [email protected] and I'll fix it quickly!
Find us on Facebook: Facebook.com/GPWeather
Or Twitter: @F1Weather
This App is unofficial and is not associated in any way with the Formula One group of companies. F1, FORMULA ONE, FORMULA 1, FIA FORMULA ONE WORLD CHAMPIONSHIP, GRAND PRIX, FORMULA ONE PADDOCK CLUB, PADDOCK CLUB and related marks are trademarks of Formula One Licensing B.V.
Whats new
- Fix for distorted images! (on newer Android 6 phones)
- Results track selection dialog now cancelable
- A screenshot is now attached when the share button is pressed!
Xclusion media part of our Sports and have average installs from 100 to 500. Last Update July 9, 2016. Google play rating is 86.875. Current verison is 2.492. Actual size 15.0 MB.
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MOTO NEWS & WEATHER '16 ADFREE9 Comments
Moto News & Weather '16 MOTOGP1060 Comments
2 Comments
Damian Stulner
Not impressed The free version was ok so I decided to go to the paid version, since then the result and session notifications have all stopped working.
Alex Zykalov
Good, but still needs some improvement Good. Needs teams and drivers info. Also in results of events and in pilot standings it would be good to see reference to team/engine and country. Russian language would be a plus too. Author does his work well, often upgrades, etc. We appreciate this. Даня, вперёд!


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Acceleron® Seed Applied Solutions, Corn, Two Year Avg.1
Don't risk using generic protection on premium corn seeds. Acceleron® Seed Applied Solutions offer the broadest spectrum of early season disease and pest protection.1
Exclusive combinations of active ingredients work quickly through the plant, protecting it from root to stalk. Multiple modes of action help reduce disease pressure and encourage even emergence. Not only are seeds protected during the critical first 30 days, but crops are also protected as they grow, which helps maximize yield potential at harvest.
Introducing for 2017, three customizable whole-bag solutions, plus exciting new technologies, from Acceleron® Seed Applied Solutions and Monsanto BioAg. These seed applied product offerings defend corn plants from early- and mid-season threats, and help increase nutrient availability and enhance root and shoot development. See how they work together to help maximize every input and investment, and increase yield potential.
Excellent control of soil and seedborne diseases, including Fusarium, Rhizoctonia and Pythium
Protection from early season pests, such as wireworm, seedcorn maggot, white grub and grape colaspis
Enhanced protection from early season pests, such as wireworm, seedcorn maggot, white grub, grape colaspis and black cutworm
Protects against damage from a wide range of nematode species
Enhanced early- to mid-season disease control due to the reduction of infections caused by Fusarium, Rhizoctonia and Colletotrichum
This biological product contains Penicillium bilaiae, a microbe that helps increase phosphate availability; helping to enhance root and shoot development and improve yield potential. It's included on all new corn products launched in 2017.
Bu/A vs. Reference
Offered with Acceleron® Seed Applied Solutions ELITE, Enhanced Disease Control Offering can deliver a 3 Bu/A* yield advantage through enhanced early- to mid-season disease control due to the reduction of infections caused Fusarium, Rhizoctonia and Colletotrichum.
*Over 5 years of Monsanto Trials versus Acceleron Seed Applied Solutions STANDARD.
2011: +2.0 Bu/A Yield Advantage
2012: +5.8 Bu/A Yield Advantage
2013: +1.6 Bu/A Yield Advantage
2014: +2.5 Bu/A Yield Advantage
2015: +2.9 Bu/A Yield Advantage
Acceleron® Seed Applied Solutions with Poncho®/VOTiVO® combines the number one corn seed-applied insecticide with a new approach to nematode protection. Poncho/VOTiVO creates a living barrier around the seed that defends against white grub, seedcorn maggot, wireworm, grape colaspis and black cutworm, as well as a wide range of nematode species. It's maximum insect protection for maximum yield potential.
Compared to Acceleron® Seed Applied Solutions alone, Acceleron® Seed Applied Solutions combined with Poncho®/VOTiVO® seed treatment yielded a two-year average of 3.7 Bu/A more corn in nationwide trials with a 62% win rate.2
This exceptional yield advantage is why SmartStax® RIB Complete® products are pretreated with Poncho®/VOTiVO®.
1Source: 2011 and 2012 Internal Monsanto Technology Development Trials. Individual results may vary.
2Monsanto Field Trials; N = 746. Represents the average advantage of Acceleron® Seed Applied Solutions Standard with Poncho®/VOTiVO® versus Acceleron® Seed Applied Solutions Basic.
1Source: 2011 and 2012 Internal Monsanto Technology Development Trials. Individual results may vary.
2Monsanto Field Trials; N = 746. Represents the average advantage of Acceleron® Seed Applied Solutions Standard with Poncho®/VOTiVO® versus Acceleron® Seed Applied Solutions Basic.
Monsanto Company is a member of Excellence Through Stewardship® (ETS). Monsanto products are commercialized in accordance with ETS Product Launch Stewardship Guidance, and in compliance with Monsanto's Policy for Commercialization of Biotechnology-Derived Plant Products in Commodity Crops. This product has been approved for import into key export markets with functioning regulatory systems. Any crop or material produced from this product can only be exported to, or used, processed or sold in countries where all necessary regulatory approvals have been granted. It is a violation of national and international law to move material containing biotech traits across boundaries into nations where import is not permitted. Growers should talk to their grain handler or product purchaser to confirm their buying position for this product. Excellence Through Stewardship® is a registered trademark of Excellence Through Stewardship.
B.t. products may not yet be registered in all states. Check with your Monsanto representative for the registration status in your state.
IMPORTANT IRM INFORMATION: Genuity® RIB Complete® corn blend products do not require the planting of a structured refuge except in the Cotton-Growing Area where corn earworm is a significant pest. See the IRM/Grower Guide for additional information. Always read and follow IRM requirements.
Individual results may vary, and performance may vary from location to location and from year to year. This result may not be an indicator of results you may obtain as local growing, soil and weather conditions may vary. Growers should evaluate data from multiple locations and years whenever possible.
ALWAYS READ AND FOLLOW PESTICIDE LABEL DIRECTIONS. Products with NemaStrike™ Technology are not registered in all states. The distribution, sale, or use of an unregistered pesticide is a violation of federal and/or state law and is strictly prohibited. Check with your local Monsanto dealer or representative for the product registration status in your state. Roundup Ready® crops contain genes that confer tolerance to glyphosate, the active ingredient in Roundup® brand agricultural herbicides. Roundup® brand agricultural herbicides will kill crops that are not tolerant to glyphosate. Acceleron®, DEKALB®, Genuity Design®, Genuity Icons, Genuity®, Monsanto BioAg™, NemaStrike™, Optimize®, QuickRoots®, RIB Complete and Design®, RIB Complete®, Roundup Ready 2 Technology and Design®, Roundup Ready 2 Yield®, Roundup Ready®, Roundup®, SmartStax® and TagTeam® are trademarks of Monsanto Technology LLC. Deltapine® is a registered trademark of Monsanto Company. Channel® is a registered trademark of Channel Bio, LLC. ILeVO®, LibertyLink® and the Water Droplet Design®, Poncho® and VOTiVO® are registered trademarks of Bayer. Herculex® is a registered trademark of Dow AgroSciences LLC. All other trademarks are the property of their respective owners. ©2017 Monsanto Company


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Upper Description
- Water Resistant synthetic leather upper.
Inner Description
- Encapsulated Nike Air unit in heel.
- Full-length comfort sockliner.
Outer Description
- 1-Year Limited Waterproof Warranty.
- Nike Power Platform. •Men's Universal Last. •Scorpion Stinger Spikes and Tri-Lok system.
Nike Stylee 818728-101
Write Your Own Review
Shipping Info
Online Shipping Information
Austads.com offers simple, flat-rate shipping to destinations in the continguous U.S. via UPS.
- Ground (3-5 business days) - $7.99
- 2-Day Air - $19.99
- Overnight - $49.99
Our policy is to strive for the best possible combination of price and service for your shipment.
In order to better serve our guests, we will occasionally offer discounted shipping promotions. Any shipping discounts will be applied in your shopping cart.
Processing Times
Orders completed by 12PM CST (1PM EST) ship out same day! All other orders will be processed and fulfilled within one business day. Orders must be placed by 12pm (CST) Monday-Friday in order to be eligible for that day's "Overnight" or "2-Day Air" shipments.
Estimated Time To Deliver
Austad's Golf is centrally located in Sioux Falls, South Dakota. Most items ship directly from our warehouse there and average 3-5 business days for ground delivery. See the map below for estimated ground shipping delivery times for your area.
"Overnight" shipments will arrive the next business day (excluding weekends and holidays) after departing Austad's Golf. "2-Day Air" shipments arrive in two business days after departing Austad's Golf. On-time delivery for both methods is guaranteed by our preferred carriers.Shipping delays may occur during busy Holidays or in the spring -- we will do our best to accommodate last minute and expedited orders placed during these times.
Hawaii and Alaska Shipments
UPS Next Day and 2-Day Air are available for customers looking to have products shipped to Hawaii or Alaska.
International & Canadian Orders
Unfortunately at this time, Austad's Golf only ships to locations within the United States.
Free Shipping Restrictions
Due to manufacturer restrictions, we cannot offer free shipping on any order with PING products. Some oversize items such as cart bags, package sets and travel covers are not eligible for free shipping.
Sales Tax Details
Austad's Golf has physical locations and charges sales tax on orders shipping to the following states: Iowa, Minnesota, Nebraska, North Dakota and South Dakota. Orders shipping to states other than the five listed will not be charged sales tax.


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Category Archives: Real Estate
The 5 Commandments of Homes And How Learn More
How to Sell Your Windsor Apartment Marketing your apartment might be among the many stressful encounters in life in accordance with many lifestyle trainers. If you are purchasing a home within a chain, usually you depend on so many external components even if you do everything close to your end of the bargain it usually does not matter. Nevertheless, let us hypothetically say you are just focused on selling your home – in this instance any normal city center apartment. Most of the tips and hints will depend on if you are residing in the apartment whilst you are marketing it or not, which could have a huge effect. Let's assume that you will be still living there. Probably the largest bit of guidance we can offer you is always to try to disassociate yourself with all the apartment. Particularly when considering selling an apartment in a developed region, try to prepare the appointments at that time of day that you realize is ideal for natural daylight entering the apartment. This is simply not usually possible as viewings tend to be organized around working hours, but when at all possible, this can be a great idea. Additionally, if you should be requested to supply pictures – this can be a good time to take them. Again, clear points occasionally need mentioning, for example, any neighbors who have a tendency to play loud music when they get home, avoid these times. Some property brokers have advised preparing fresh coffee or having freshly cut flowers. This next piece of advice may well not continually be feasible, based on the way your apartment may be available on the market, and how much mess you've within the apartment, but the idea of a clear material makes things easier for individuals to imagine themselves living in your house. Many people recommend whitewashing the surfaces, as it does not disturb the shades you might have selected, but this is often a costly choice that not most people are ready to spend in. Another idea would be to eliminate private photos and images, for example, as this creates a far more "homely" feel – individuals don't desire to see how delighted you're inside the apartment, rather envision themselves there. When possible, do not make it seem "lived in" a lot. Typically an empty apartment sells a lot quicker than a flat that is being lived in.
5 Takeaways That I Learned About Sales
Take a look at your home from an outsider's perspective. Try and brighten the area which frequently does not suggest purchasing fresh items – instead tossing out litter or old components of furniture which often gets in the way. Ensure to keep things in order, specifically for visits, even if you are a messy person. Ensure it seems like you take care of the place and it will sell easily.Getting To The Point – Apartments
Short Course on Fences – What You Need To Know
Vinyl Siding Alternatives & the Significance of Appropriate Installation
Among the most famous options for fencing is vinyl siding. Whether you're building a new home or considering of resurfacing your existing home, this sort of siding is an appealing choice to consider. In comparison with other stuff, it is the most inexpensive and quite versatile. Made from polyvinyl-chloride, this siding alternative is pre-colored when manufactured. It can be found in numerous distinct colors, so you won't have to paint it. Some vinyl is produced to look like a wood grain finish for people who desire the appearance of a natural substance. It is also supplied in many different styles, such as beaded designs or horizontal or vertical banding. Although it has been used for a lot more than fifty years, changes are produced in the manufacturing process to improve the durability of this stuff.
If the present siding in your house is old vinyl, you might find some weather-related damage. For instance, it might have a yellowed or buckled look as a result of exposure to severe heat. Older materials also tend to break in intense cold weather and strong winds make them loose. Because of improved production procedures and testing, newer stuff usually do not demonstrate these sorts of wear. Contemporary stuff may likewise have other characteristics or remedies that make them more resistant to weather, including fade-resistant coatings, high wind resistance ratings, and superior depth.
The thickness of vinyl siding is measured in pointers, and is usually between . 040 and . 045 inches heavy. Some superior manufacturers, who are generally more costly, may be as much as . 055 inches thick. The thickness is one variable that establishes price and durability. A top quality brand of the siding can continue to look brand new for several years. Even the finest quality color probably will fade or break after just a couple of years of exposure to the sunlight and other components.
Practical and Helpful Tips: Services
When you decide to use vinyl siding, the most noteworthy measure for stopping difficulties is correct setup. Because of this, it's a good idea to employ a qualified siding contractor to perform the job unless you have experience with this sort of work. Poor setup can permit water to collect behind the siding and trigger the inside walls to decay. If each piece of siding is not correctly leveled and nailed, it may cause a "ripple effect". This describes the appearance of a clasp or swell in the siding, which will be generally more obvious on the vinyl fence. Vinyl doesn't supply a leak-proof covering because it enlarges and contracts with temperature changes. A protective water resistant barrier, referred to as a residence wrap, is needed underneath this siding material. If the residence wrapping is just not installed first, this may also cause water damage and leaks.
Why Homes Aren't As Bad As You Think
Vinyl siding is among the most lasting and versatile possibilities, but it should be correctly installed to avoid issues. Despite the fact that you may possibly have to employ a siding contractor, the price tag on installing is equally cost-effective because the substances are inexpensive. You can find several other kinds of siding to choose from. If you decide to install vinyl siding, make sure you carefully follow installation directions or hire a siding contractor.
If You Think You Understand Lenders, Then This Might Change Your Mind
Features of Registration Loans
Logbook indicates an automobile registration document. A logbook contains records regarding the operator of the vehicle, listed owner, frame number, present enrollment tag, motor number, design and color of the car. You know various means of borrowing but, are you aware you can borrow a loan using a logbook. Yes, it is genuine; you will access a logbook loan.
Consumers may benefit from total independence to drive their vehicle with no limitations from the bank. The loan amount is decided based on the value of the car minus any funds due to be paid on the remainder of the car loan. Subsequent requirements are to be met to become entitled to a logbook loan. To be eligible for a logbook credit, the logbook should be in the borrower's name. The automobile ought to be less than eight years old. The automobile ought to be free from any financing activities. The automobile must be under an insurance scheme and tax paid on it. The lender needs to take caution and ensure that the car has some insurance.
A credit rating is considered to be a significant aspect while lending money to the consumers by lenders. A good thing about logbook loans is the fact that it does not include a credit check. If you meet with the above considerations, you're qualified to receive a logbook loan no matter your circumstance. Issue like individuals who have bankruptcy cases filed in court are not even relevant and can also apply for this loan.
5 Uses For Funds
Logbook loans could be borrowed from banks or finance institutions. But, in case you are looking to get a fast and efficient logbook loan, you can submit an application from online borrowers. Online loans provide the person applying great ease. Using the web at home or the workplace, a consumer may access endless amount of online creditors. The procedure of trying to get an internet loan is quick. Financing websites typically offer an internet application form on the sites, which a client is supposed to fill. A borrower simply must fill this with a few personal details including customer's brand, loan quantity required and several other facts. These specifics enable a lender to get the most suitable loan for that borrower.
Loans Tips for The Average Joe
When you may go online, you will find many creditors who'll be ready to offer you the loan. But, don't get taken away by their attractive offers. Perform a little research and you'll undoubtedly find a better choice. Acquire loan quotes from many creditors which are available cost-free or for reasonable charges and compare them to obtain the greatest and cheap logbook loan. It's incredible that besides experiencing an extended drive in your car, you may also get a loan against it. Thanks to logbook loans credit has become easily accessible.
Lessons Learned About Services
Build Your Finance Knowledge with Finance Forums
Finance is an essential part of every business. You need money to start and run any business. In addition to funds, you should also have information on how to successfully run your business. You may solicit business information from your friends and family. This will enable you to properly run your business. Nonetheless, the information from family and friends may be insufficient. You might be required to search for extra professional advice from people with experience and skill in business. Therefore, you may have to join a finance forum.
Financial community forums have a lot of resources that assist many business persons. In essence, they are platforms for people to share their advice, air their opinions, and discuss about finances. Joining finance forums can be really beneficial to you. Finance forums usually discuss topics like inflation, important business financial resources, and the change of stocks. They help members to be aware of what is going on in the financial world. There are usually sections in the forums that discuss sectors as well as aspects of the economy. In addition, they bring together clients, investors, general enthusiasts of finance, and stockholders to work together and benefit financially.
Financial community forums primarily aim at educating and informing members about stock market events. You will meet sellers of shares, individual investors, and buyers. Finance forums let you know about the current state, as well as profits and losses of any company. This helps members make sound decisions when selecting the business they want to work with.
How I Became An Expert on Finances
Some of these forums also offer projections on the profitability of a company. This kind of information prepares members for business shocks and surprises to expect in the future. Finance forums are appropriate places for people to share their doubts and questions with the experts. There are professionals ready to offer assistance to you and answer your queries. You can rely on them for crisp and practical business solutions. You won't need to use a financial adviser as you can assess many of them on the forum.
The Art of Mastering Forums
Members don't need to pay anything in these interactive platforms. This is because finance forums aim to provide assistance to its members. Therefore, everyone in the site benefits in one way or another. A large amount of the information is shared freely, thus nobody expects to be paid for their answers, comments, or suggestions.
Finance forums enable you to secure your business by eliminating your doubts about managing your own business. They let you interact with like-minded people. You need to sign up with a finance forum to benefit from information that's offered for free. Look for a finance forum that fits your business interests. Make sure you find one that many people trust.
The 4 Most Unanswered Questions about Homes
Is a Local Realtor Really Needed?
When you have already made up your mind to sell or buy a home then you should know that it is important to speak with a local realtor. You need to talk with a local realtor due to two important reasons: to know what to expect during the steps in the real estate transaction and to know everything about the current real estate market. Below are the other important reasons why you should make sure that you will be able to talk with a local realtor.
It is as a matter of fact the local realtor that is best suited for the job of selling your home if this is what you have decided. The local realtor will be able to give you valuable information about the prices and what is currently going on in the local area as well. As a matter of fact, there are those people that will tell you that the kind of information that they have is the same with those of the local realtors. What you have to bear in mind is that there is a great difference between people that drive the streets on a daily basis and those that just read the screen. When dealing with a local realtor, you have to keep in mind that you should be able to hire someone that is well knowledgeable with your neighborhood. In this manner, you can make sure that up to date information is provided to you which is why this is important.
One thing that you should know about the task of buying a new house is that you will still need a local realtor. The local realtor will be able to give you access to the homes that are for sale. A local realtor is as a matter of fact what you will really be in need of when you are moving to a new area. Information that you are in need of is for sure to be provided by the local realtor. Learning about the job prospects and school systems are only some of the many information that you will be able to learn. This is the main reason why you need to be able to find a well established local realtor. A well established local realtor has enough knowledge and experience as well in order to find you the right home.
Another reason why you should have a local realtor by your side is during the buy and sell process. It is the local realtor that will lead the way in the process. This is to make sure that no detail will be overlooked and so that you already know what to expect. So at the end of the day, you can say that the local realtor is really needed.
Cite: wikipedia reference
What Has Changed Recently With Properties?
Costa Rica Real Estate: Living in Paradise People are definitely interested in everything real estate. Costa Rica real estate is definitely something you should consider investing on. This would be a great location for rest house. This venture is all about choosing property that would make you happy in more ways than one. It would be a dream to build a house near the coastal areas of this place. Purchasing a house comes with conditions which you constantly have to be aware of. When it's located in a place this grand, you need to make sure you're up for the task. Before making a decision, you actually have to know more about the country itself. This would especially be the case when you plan to settle this home. Even if it's only going to be a second home for you, you still need to do the same. Consider what your family thinks of the home and the location before you choose it. Get your real estate agent's opinion on the place when you have him or her check it out. You should definitely check out the homes with really great prices in this awesome place. It's always great when you're able to pay low property tax which is the advantage of living in this country. The fact that this is able to reduce your expenses greatly is something you need to take full advantage of. If you compare living here to other countries then it would actually be a lot cheaper. It would truly be the perfect place to settle after you retire. You can just relax without worrying about your expenses too much. Living in these areas will bring you tons of happiness in more ways than one. You have to research on the price of these homes before anything else. This way, you would be able to know how much you'd need to pay annually. The differences in these particular aspects would matter to a lot of buyers. You want to budget your payments properly because this is always going to be a part of owning a house. You need make sure that this particular matter is handled in the most essential way. It's a lot more affordable buying property in this place compared to anywhere else. It has clean water that is both cheap and easy to access. Another amazing thing about this place is it's beautiful climate. You can head to the beach every single day because the weather would be perfect for it. Living would be so much more convenient with all the convenient amenities nearby as well.Practical and Helpful Tips: Properties
Questions About Properties You Must Know the Answers To
Important Things That You Need To Know When It Comes To Buying Costa Rica Real Estate It has been such a long time ever since real estate came to life and not just that, up to this very day, the number of individuals who are investing in real estate has greatly increased and that is because they were able to gain more than the amount they have invested on it. One very effective way for you to invest your money is to buy Costa Rica real estate because it has been known that Costa Rica real estates are always a good option due to many different reasons such as high interest the investment, the cost of living and property taxes are surprising real low, and as for foreign residents, they will be able to save from the taxes alone. In addition to that, another reason why Costa Rica real estate is definitely a must have property is due to the charming and breathtaking beaches that are lined with lanky coconut palms, housing that are not expensive, and medical system that are up-to-date, And of course, there is no need for you to worry about anything when buying real estate in Costa Rica as the ownership is entirely ensured be mandated by their constitution, even to the foreigners. Depending on the amount that you will be investing on, there are actually quite a number of properties that you can choose from in Costa Rica real estate like vacations rentals, farms, hotels, resorts, condos, houses, luxury homes, castles, mansions, lots, and also coastal estates. When it comes to acquiring the properties that are mentioned above, you must go over a deed of public ownership before you can own it. According the latest survey that was conducted by a trusted surveying company, it goes to show that among the one hundred forty countries all over the world, Costa Rica is in the twenty seventh position of countries that are safest for investment. In order for you to be able to buy the real estate property suitable as investment, listed below are some tips that will certainly be of good use to you when buying one. The very first thing that you need to do is to make sure that you have defined all the needs that you have in accordance to your budget, most especially if you are going to consult your real estate agent. Aside from that, another significantly essential thing that you need to do is to know and be aware of the basic Costa Rican laws when it comes to real estate as you will be required to get familiar with it. If you have any question with regards to their laws and rules when it comes to real estate, you can ask your real estate agent to educate you about it.The Beginner's Guide to Sales
Homes: 10 Mistakes that Most People Make
Why Homeowners and Property Owners Invest in Bathroom Remodeling What do you think are the reasons why there are numerous property owners who invest in remodeling their bathrooms? If you haven't undertaken this project because you are doubtful about it, then continue reading this article to obtain insights of its benefits. No matter how small or big your house might be, it is vital for you to include your bathroom in whatever upgrades, remodeling and refurbishments plans that you have. Your bathroom is one of the most vital places in your house, therefore be sure to make it functional and appealing always. Why the Bathroom Is Very Important?
The Beginners Guide To Remodels (What You Need To Know To Get Started)
The bathroom is very important to all residents of the house because of the diverse functions it serves. We go to the bathroom for bathing, peeing and removing our bodily wastes. It serves as our refuge when we felt tired and down. With the tons of uses that our bathrooms serve us, it is just right that we keep this place in tiptop shape and appealing always. You can realize these things by remodeling our bathrooms whenever needed.
Questions About Houses You Must Know the Answers To
The Other Reasons for Remodeling the Bathroom 1. One of the prime reasons for remodeling the bathroom is to keep abreast with the newest bathroom trends. 2. You can also find lots of property owners and homeowners who remodel their bathrooms simply because they want to update its theme. 3. There are also those property owners who remodel their bathrooms to change the damaged and worn-out fixtures. 4. There are some property owners and homeowners out there who opted to remodel their bathrooms because they want to boost the value of their properties. Studies show that bathroom remodeling can give property owners return on their investments of between 80% to 90%, especially those who decide to sell their properties. Irrespective of whether you carry out partial or complete remodeling of your bathroom, it is indeed a worthwhile and beneficial project to pursue. What Factors to Consider When Bathroom Remodeling? 1. First and foremost, it is very important that you determine first what kind of remodeling you want to carry out. Do they want to pursue complete or partial remodeling of the bathroom? 2. It is also advised that you take into account the budget allocated for this specific endeavor. Money is one vital determining factor of the extent of remodeling that you have to do in your bathroom. 3. Make sure that you take into vital consideration on the contractor that you will hire for this specific project. Should you want the project to be successful and of good quality, then you are advised to hire only reputable, licensed and experienced bathroom remodeling contractors. Prior to hiring a contractor, you are advised to check out and to investigate first to know their track history and performance. These are simple and easy tasks that you can follow when you desire to remodel your bathroom in the near future.
Should You Actually Let or Obtain in the UK?
In case you and your entire family have already been considering moving to the UK, you might be pondering if perhaps and where you should get a property. You could wish to reevaluate the concept of the purchase of a property immediately, notably if you shall be in the area for a long time, since the district you imagine you want to stay may not be the one you finally actually love the the absolute most! For this reason, it might be recommended for you to let a house in the UK just for a period of time, just till you will get a feel with respect to where by you wish to settle permanently. This allows an individual that opportunity to possess a temporary foundation with which to discover your brand new atmosphere! You'll be able to determine what surroundings you enjoy most, just what shops, dining establishments, and so on. One very good thing will be that a person should not have any difficulty in discovering a nice destination to stay in. Often times, you'll actually find a new house for rent, because a variety of contractors would rather possess some cash arriving in instead of none. If you are letting, you can spend some time in researching the options about what could eventually grow to be your current everlasting residence.


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Louvre Interior shot, directly below the large pyramid from the bottom floor.
aww stop copying me spyed
i'm dizzy @u@
that looks awesome! nice angle for it
Its so groovy!
Didn't that get blown up in Team America: World Police?
I guess they must have rebuilt it...
I guess they must have rebuilt it...
this pic makes me dizzy @_@ but i like it!!
do up and down this page dude . It's awesoome
Nice effect when scrolling it up'n'down!
I've seen this monument a lot of times...
I visit it too...
But i've never thougth of this shot ...
Really nice!
I visit it too...
But i've never thougth of this shot ...
Really nice!
Great architecture photo
This makes me want to watch The Da Vinci Code again ^^
Great shot
Great shot
This is great!
nice perspective!
nice perspective!
It's so trippy if you scroll up and down really quick...
Come on, you know you want to do it
Come on, you know you want to do it
wah makes my eyes hurt...but in a good way. Really cool
I really like how the top of the pyramid points to the center of the ceiling and from the distance how it looks like the corners of the picture of converging kind of like the photoshop pucker tool. nice.


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A federal judge has blocked Vermont from shutting the state's only nuclear power plant in March because of safety concerns.
U.S. District Court Judge J. Garvan Murtha ruled that the federal government has exclusive authority over the operations of nuclear plants, theBurlington Free Press writes.
Entergy Nuclear, which had sued to block the shutdown of its Vermont Yankee facility, won a preliminary injunction that will allow the plant to operate beyond March, when its initial license expires. The U.S. Nuclear Regulatory Agency had renewed the license for another 20 years.
The judge, however, "couched his decision," the Free Press writes, "as specific to the case and not a reflection on the rewards and risks of nuclear power. He also noted that his ruling does not preclude Vermont from refusing to grant a state operating license to the reactor on grounds that federal law allows. In this case, Murtha noted, the Atomic Energy Act prevents the state from shuttering Vermont Yankee over safety concerns."
Entergy praised the ruling, calling it "good news for our 600 employees, the environment and New England residents and industries that depend on clean, affordable, reliable power provided by Vermont Yankee."
Doug is an unrepentant news junkie who loves breaking news and has been known to watch C-SPAN even on vacation. He has covered a wide range of domestic and international news stories, from prison riots in Oklahoma to the Moscow coup against Mikhail Gorbachev. Doug previously served as foreign editor at USA TODAY. More about Doug
Michael Winter has been a daily contributor to On Deadline since its debut in January 2006. His journalism career began in the prehistoric Ink Era, and he was an early adapter at the dawn of the Digital Age. His varied experience includes editing at the San Jose Mercury News and The Philadelphia Inquirer.
Also: Follow On Deadline on Twitter


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The endorsement will be a boost to BP, as it attempts to draw a line under its Gulf of Mexico oil spill by on Tuesday announcing the departure of chief executive Tony Hayward and revealing hefty impairment charges of up to $25bn (£16bn).
The board is expected to say that Mr Hayward will leave on October 1 to be replaced by the American managing director now in charge of BP's spill response unit.
It is understood that Mr Hayward will now take a position on the board of TNK-BP, rather than sever his ties with the oil giant.
Mr Dudley had to flee Russia in 2008, due to a bitter argument over his stewardship of TNK-BP, the 50-50 joint venture that produces a third of BP's total oil output.
Lord Robertson, the venture's chairman, then accused the Russian shareholders of "an orchestrated campaign of harassment" against Mr Dudley that caused him visa problems and surveillance of staff – which they denied.
BP confirmed on Monday night that Mr Dudley still does not have a visa allowing him to work in Russia after the problems of two years ago.
However, it is understood that the AAR consortium of four Russian investors whi control half of TNK-BP are prepared to set aside old differences with Mr Dudley.
A source close to the Russian shareholders said: "We don't see this as a problem. Actually it could be a positive as Bob knows Russia so well. Bob was stuck in a difficult situation. It was never something personally directed at him. There are no issues towards him from AAR."
He also dismissed suggestions that either BP or AAR would sell part of their stake, saying both sides of the partnership were happy.
Analysts said that Mr Hayward could take on the role of Russian ambassador for BP, smoothing over relations with the co-investors.
BP's shares rose 18.35, or 5pc, in London to 416.95p, on reports of the management changes almost 100 days since the Deepwater Horizon exploded, killing 11 men and triggering the leak.
However, the White House warned that BP's work in the Gulf is not over yet. "Regardless of who leads the company, those obligations and responsibilities must be met," a spokesman said.
BP will on Tuesday announce "clean" profits – which strip out the cost of inventory changes and exceptional items – of about $5bn for the second quarter, according to forecasts. However, there will be a large provision for the cost of the spill between $13bn and $25bn, causing it to swing to a record pre-tax loss.
BP is expected to announce an accelerated programme of asset disposals, after negotiating the $7bn sale of non-core fields to Apache last week. It was already planning to sell $10bn of peripheral assets, but could increase this to $20bn.
Analysts believe the total bill for the spill could be between $37bn and $100bn.


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Auld Lang Syne PIANO (jazz-feel) FREE SHEET MUSIC + MP3 + Copy-Hands Tutorial MP3
PLEASE SEE VIDEO INFO. BELOW FOR SHEET MUSIC LINKS ⬇⬇ For New Year 2016 here's "Auld Lang Syne" in a jazz-feel piano solo arrangement.
Auld Lang Syne (instrumental - lyrics video for karaoke) MP3
Free mp3 download: http://www.singing-bell.com/auld-lang-syne-mp3 Visit http://www.singing-bell.com/ to download your free instrumental mp3 of "Auld Lang ...
Auld Lang Syne MP3
Just a little video I recorded to wish you a Very Happy 2015! Visit http://www.rickstone.com to get a free MP3 from my latest CD The Rick Stoen Trio "Fractals."
Country Christmas - Auld Lang Syne (Karaoke) MP3
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"Auld Lang Syne" - T.S. Miller MP3
We'll take a cup of kindness yet, for auld lang syne... Happy holidays, guys! If you're interested in a free mp3, let me know. If enough people are interested I'll set ...
Auld Lang Syne - feat. Bryan Estabrooks MP3
Enjoy our acapella rendition of Auld Lang Syne and thanks for watching! If you enjoyed give us a thumbs up! Join my monthly mailing list for a free Mp3 ...
Auld Lang Syne (Vocals) - Jingle Punks- Listen to free mp3 music onlin MP3
John Hodgman and Jonathan Coulton ❄ Auld Lang Syne ❄ 'Ask Me Another' 2013 Holiday Spectacular MP3
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Auld lang syne by Bing Crosby Merry Christmas and happy new year! Other Christmas songs: Home for the holiday - Perry Como ...
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Other name: None
Status: Completed
Viewed: 220
Summary: Saving a helpless boy from being dressed up as a girl against his will, Chihiru Kanno is amazed at just how beautiful the half naked boy is. On the other hand, is she in for more trouble than she bargained for? The little boy she saved turns out to really be the older brother of the younger one that she has a crush on! In any case, Nakajou, the older one, has taken a liking to her. And what's this? He also wants to have sex with her?! Is seduction the key into getting into Chiharu's pants, or will true love in the form of the younger brother Maki, appear? Find out how this mess is resolved in: Dangerous Love Triangle, by- Yuzuki Jun -Summary written from scratch by: Take-me-away-to-paradise THIS IS A ONESHOT FROM PINK NO IDENSHI SERIES


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Allie Summers Model
My Website: It's the FacebookMy MM URL: http://www.modelmayhem.com/samcomerphotos
Mayhem # 415073
About Me
I take pictures. I make movies. (See my filmmaker page at modelmayhem.com/2816751)
I'm not shooting as much as I used to because career and stuff have gotten in the way a bit, but I am really itching to get back to doing some regular shoots. Something on the more artsy and fun side of things. And on that note, since it's more of a for fun and the sake of art sort of thing, I neither pay models nor do I charge anything. TF-whatever for me.
(I have been known to trade headshots or portfolios for acting time in one of my films).
I no longer have a home studio, so it's likely mostly going to be on location.
Anyhoo ... that's the long and the short of it.
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Like many of the academies founded as a result of the government's school building initiative in 2000, Corby Academy in Northamptonshire has a specialist academic focus that is driven by its links with the local community – in Corby's case, this is 'Business and Enterprise'. Accordingly, the design aims to create a stimulating, professional environment that encourages teamwork and entrepreneurial spirit and can help to prepare students for the world of work.
The simple rectilinear two-storey building is punctuated by six glazed atria, three on each side, which open the building to daylight and views of the surrounding countryside. Rather than supporting pastoral 'house' spaces for the 1,200 students, the atria are subject-focused and distinguished by bold colour-coded signage and upholstery. The classroom walls are fully glazed, animating the central spaces, while allowing natural supervision, and to ensure peaceful study, the teaching and circulation areas are carpeted. Inside and out, the materials palette is designed to be durable: the solid façade contrasts polished black stone at either end with textured silver block work along the building's length. The main entrance is protected by a large steel roof canopy, and sheltered on one side by the double-height block containing the sports hall. A separate community entrance to the south provides access to the academy's flexible 650-capacity theatre and restaurant, and enables the facilities to be used by the wider community out of school hours.
A designated special provision unit housed within one of the atrium hubs provides specialist facilities for around 70 disabled students. The atrium is semi-private, so that activities can be as discreet or integrated as required, and the space contains a hydrotherapy pool and a small landscaped garden. The design also incorporates a number of energy saving features, including wind catchers on the roof, which help to naturally ventilate the classrooms; angled walls at the back of the ground floor classrooms that sit below light wells and bring daylight into the furthest recesses of the building; movement sensors on light fixtures; and fritting on the glazed atrium to reduce glare while maximising natural light.
Sketches + Drawings
Facts + Figures
- Appointment: 2004
- Completion: 2008
- Area: 11 745m²
- Client: Beebee Devlopments, Brooke Weston Foundation, Corby Academy Trust, Garfield Foundation
- Structural Engineer: Buro Happold
- Quantity Surveyor: Davis Langdon
- M+E Engineer: Buro Happold
Related Press Release
New Academy in Northamptonshire opens
Corby Academy starts on site


text:
MacBook Pro 2016 release date may happen soon as the current 15-inch MacBook Pro 2015 received a generous discount along with freebies.
According to Apple Insider, Apple authorized reseller Adorama is exclusively offering AppleInsider readers free AppleCare extended warranty protection plans, a free Canon PIXMA MG3520 Wireless AirPrint Inkjet Photo All-in-One Printer, and additional cash discounts with the purchase of Apple's most popular 15″ MacBook Pros.
Cash discounts went as high as $440. If you are not interested with the freebies, simply use APINSIDER promo code and it will knock off an additional $70 on Adorama's already reduced pricing on all mid-2015 15-inch MacBook Pros.
It was thought that the device will be released in December last year. According to Australia Network News that cited Pike's Universum, which spotted a new Mac code heavily points to a new MacBook Pro. However, the developer is also mulling whether the code is meant for other Apple products like iMac and Mac Pro
"The data is identical to that of the late 2015 (iMac 17,1 in the same file) so it might as well be a remnant of the new iMac, but the strange thing is that the XHCI data for the late 2015 iMac is also there… there are too many USB 3 ports defined to fit on a MacBook [Pro] and Mac Mini. This and the fact that there is already support for newer graphics chips [baked] into El Capitan… is why I think that it was added for a new Mac Pro," the post reads.
Consumers are not only waiting for the MacBook Pro 2016, but for MacBook Air 2016 as well. The latter is also rumored to be released either later this year or early next year.
MacBook Air and Pro 2016 are rumored to retain the sizes of the original, but will be packed with powerful specs and features, including the latest Intel Skylake processors. The laptops will also run with the latest OS X El Capitan.
However, there is still no word from Apple regarding the details of the two MacBooks.
macbook pro 2016 launch, macbook pro 2016 release date, macbook pro 2016 rumors, macbook pro features
Kristin Dian Mariano
Up Next
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Lake is the new sea, and we are lucky to have many lakes close to the city for us to jump in during the weekend. After a hot day of swimming or sailing, nothing better than going directly to a nice restaurant and reload energy. What to wear? Stripe is a classic which is renewed each Summer. Fashion designers like Armani, Chloé, Elisabeth and James, MSGM are some inspirations for you. Stripes can be worn with sneakers, flat sandals, espadrilles, high heels, better in red, blue and white, to finish the navy look perfectly. We wish you a wonderful Summer, with many short trips to the lake or to the sea.
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Frankie Vaughan
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Frank Abelson, 3 February 1928, Liverpool, England, d. 17 September 1999, High Wycombe, Buckinghamshire, England. While studying at Leeds College Of Art, Vaughans vocal performance at a college revue earned him a weeks trial at the Kingston Empire music hall. Warmly received, he went on to play the UK variety circuit, developing a stylish act with trademarks that included a top hat and cane, a particularly athletic side kick, and his theme song Give Me The Moonlight, Give Me The Girl (Albert Von Tilzer - Lew Brown). His Russian-born maternal grandmother inspired his stage name by always referring to him as her Number Vorn grandchild. After registering strongly in pre-chart days with That Old Piano Roll Blues, Daddys Little Girl, Look At That Girl, and Hey, Joe, during the mid-to-late 50s Vaughan was consistently in the UK Top 30 with hits such as Istanbul (Not...
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Pain Management Helps With Sports, Auto and Work InjuriesInjuries occur every day. Thousands of people get injured at work, while playing sports, have auto accidents etc. Injuries which develop from them range from minor to chronic. It could even leave you with chronic – long-term – pain.
Sports Injuries
Every year there are more than seven million sports related injuries. Poor training practices, accidents, being out of shape, not having the proper protective gear, and not warming up properly cause sports injuries yearly. The most common sports injuries include of minor aches and pains due to sprains and strains, Achilles tendon injuries, fractures and dislocations, knee injuries, swollen muscles etc. Sports injuries should be immediately looked at by a doctor, especially if there is numbness, swelling or severe pain, feels abnormal or unstable. Sport injuries can lead to long-term pain even after treatment. The largest age group affected is those between the ages of five and 24, making up half the injuries.
Auto Injuries
Auto crash often results in whiplash. Even when the car runs at a low-speed before the coalition, the crash can cause severe injuries. Symptoms like whiplash, back pain, neck pain, muscle spasms, backache, headache, shoulder pain, leg pain, arm pain, tingling or dizziness may occur immediately, days later, or even weeks later. And pain may persist for a while even after the injury is healed, especially if you broke your bones.
Work Injuries (Workers' Compensation)
Workplace injuries occur every day, with symptoms ranging from mild to major. Anytime you are hurt yourself at work you need to report it immediately. Your employer's insurance may refuse to cover your medical charges if you don't report your injuries as soon as they occur.
Long-term pain often occurs with workplace injuries, costing employees hundreds of thousands of dollars.
Pain Management Treatment
Treatment from injuries may not be as simple as waiting for the injury to heal and the pain to subside. Many times, the pain remains, interrupting your quality of life. If you wake up in debilitating pain, or a stiff, swollen and painful knee, can't sleep because of your pain, or are withdrawn and depressed from your pain, it is time to talk to us. Call us at (813) 549-7465.
Our doctors at Genesis Medical Clinic will relieve your pain. We often combine treatments to optimize the pain relief effects. Treatment options include, physical and rehabilitative medicine, anesthesiology, chiropractic, internal medicine, pharmacology etc. Our pain management doctors will discuss treatment plans with you prior to implementing it.
We generally use medications as the primary fight against pain, at least early on. Our pain management doctors will take into consideration the medications you already are taking, how well they are working or not working, and any allergies you might have. Get your life back and start enjoying life again. Call us at (813) 549-7465.