text:
Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes
This investigation offers insights into system-wide pathological processes induced in response to cigarette smoke exposure by determining its influences at the gene expression level.
We obtained genome-wide quantitative transcriptional profiles from 1,240 individuals from the San Antonio Family Heart Study, including 297 current smokers. Using lymphocyte samples, we identified 20,413 transcripts with significantly detectable expression levels, including both known and predicted genes. Correlation between smoking and gene expression levels was determined using a regression model that allows for residual genetic effects.
With a conservative false-discovery rate of 5% we identified 323 unique genes (342 transcripts) whose expression levels were significantly correlated with smoking behavior. These genes showed significant over-representation within a range of functional categories that correspond well with known smoking-related pathologies, including immune response, cell death, cancer, natural killer cell signaling and xenobiotic metabolism.
Our results indicate that not only individual genes but entire networks of gene interaction are influenced by cigarette smoking. This is the largest
Tobacco use is responsible for more than 5 million deaths per year
Investigating the influence of cigarette smoke exposure on health is a highly complex problem. The particulate and vapor phase of cigarette smoke contains in excess of 4,000 compounds, including five known human carcinogens and many toxic agents
This study utilized large-scale genome-wide expression profiling as an alternative approach to determine the systemic influence of cigarette smoke, as an environmental exposure, on human physiology and health. Previous studies of gene expression as influenced by smoking have been seriously limited in size
Ethics statement
All protocols were approved by the Institutional Review Board of the University of Texas Health Science Center at San Antonio. Participants gave informed consent and all investigation were conducted according to the principles expressed in the Declaration of Helsinki
Study population
This investigation was conducted as part of the SAFHS, initiated in 1992 to investigate the genetics of cardiovascular disease and its risk factors in Mexican Americans
Assessment of smoking status
Smoking status was assessed by structured interview conducted during the first clinic visit between 1991 and 1995, the same time point as the lymphocyte collection for the expression profiling. Data collected included current smoking status (smoker or non-smoker) as well as an estimate of cigarettes smoked per day, all by self report. No data were available on duration or former smoking status. In addition, serum cotinine levels were measured using a commercially available ELISA assay (BioQuant, San Diego, California). Serum for the cotinine assay was obtained during the first clinic visit but was only available for 981 of the 1,240 individuals with expression profiles.
Expression profiling
The expression profiling methodology is described, in detail, in Göring
Total RNA was isolated using a modified procedure of the QIAGEN RNeasy® 96 protocol for isolation of total RNA from animal cells using spin technology (QIAGEN Inc., Valencia, CA), and a total of 500 ng total RNA dried down and stored at -20°C. Anti-sense RNA (aRNA) was synthesized, amplified and purified using the Ambion MessageAmp II Amplification Kit (Ambion, Austin, TX) following the Illumina Sentrix Array Matrix 96-well expression protocol (Illumina Inc., San Diego, CA). Synthesized cDNA samples were purified using QIAGEN's QIAquick 96 PCR purification supplementary protocol for spin technology (QIAGEN document QQ01.doc, October 2001). Biotin-16-UTP (Roche, Germany) labeled aRNA was synthesized using Ambion's proprietary MEGAscript® in vitro transcription (IVT) technology and T7 RNA Polymerase. Purification of aRNA samples was performed using QIAGEN's RNeasy® 96 protocol for RNA cleanup using spin technology, and a total of 1.5 μg aRNA was dried and stored at -20°C prior to sample hybridization.
Hybridization of aRNA to Illumina® Sentrix® Human Whole Genome (WG-6) Series I BeadChips and subsequent washing, blocking and detecting were performed using Illumina's BeadChip 6 × 2 protocol, as described in Göring
Identification of expressed transcripts
In order to identify transcripts that exhibited sufficient quantitative expression in lymphocytes, the distribution of expression values for a given transcript was compared to the distribution of the expression values of the controls that are imbedded in each chip. For each transcript, we performed a χ2 "tail" test of whether there was a significant excess of samples with values above the 95th percentile of the control null distribution. This test was used because it allows detection of even those transcripts that are clearly present above baseline levels in only a subset of individuals, while not being detectable above baseline levels in most individuals. Using a false discovery rate of 0.05, we identified 20,413 transcripts that exhibited significant expression by this criterion.
Standardization of expression values
To minimize the influence of overall signal levels, which may reflect RNA quantity and quality rather than a true biological difference between individuals, abundance values of all 20,413 retained transcripts were first standardized by z-scoring within individuals (using decile percentage bins of transcripts, grouped by average log-transformed raw signals across individuals), followed by linear regression against individual-specific average log-transformed raw signal and its squared value. Lastly, for each transcript, we directly normalized these residual expression scores by employing an inverse Gaussian transformation across individuals, to ensure that the assumptions underlying variance components-based analyses were not violated. This conservative procedure results in normalized expression phenotypes that are comparable between individuals and across transcripts.
Statistical Analyses
All statistical analyses on related individuals were performed using variance components-based methodology and software package SOLAR 4.1
We used combined discrete-continuous bivariate modeling analysis
Pathway and Networking Analysis
The 342 transcripts meeting the FDR of 0.05 criteria were analyzed using Ingenuity Pathways Analysis version 6.3 (Ingenuity® Systems,
Additional file 1
Full details of the smoking-correlated genes significant at an FDR of 0.05. Includes gene information, correlation of expression with smoking and the allocation of each gene into the functional assignments and canonical pathways from Ingenuity Pathways Analysis described in Tables
Click here for file
The right-tailed Fisher's exact test was used to calculate a p-value determining the probability that each biological function and/or disease assigned to that dataset was due to chance alone. This p-value is calculated by comparing the number of user-imported genes in a given function or pathway relative to the total number of occurrences of these genes in all functional/pathway annotations stored in the knowledge base for the reference set. We used the entire set of 20,413 transcripts that were significantly detected in lymphocytes in our study
Our genes of interest were overlaid onto a global molecular network developed from literature reported connectivity recorded in the Ingenuity Pathways Knowledge Base, allowing the generation of gene networks; graphical representation of the molecular relationships between genes/gene products. All interactions between genes and other molecules in these networks are supported by peer reviewed publication.
Accession Number
Raw expression values (of all transcripts on the microarray) and normalized expression values (of all 19,648 analyzed autosomal transcripts), along with information on sex and age are available under accession number E-TABM-305 on the ArrayExpress website
Study Summary
For this study, transcriptional profiles were obtained from 1,240 Mexican American individuals from the San Antonio Family Heart Study (SAFHS). This dataset contained 1,154 individuals from 46 pedigrees and an additional 86 singletons. There were 734 females and 506 males in the sample, with a mean age of 39.3 years (SD = 16.7 years). Ages ranged between 16 and 94 years. For each sample, 47,289 transcripts were interrogated using the Sentrix Human-6 expression BeadChip supplied by Illumina (San Diego, CA). We were able to significantly detect 20,413 expressed transcripts in lymphocytes, 62.5% of these corresponding to known genes
The prevalence of smoking in the dataset was 24%, with 297 current smokers. Using the genome-wide transcriptional profile dataset, we tested for correlations of gene expression in lymphocytes with a discrete measure of current smoking behavior, assessed by questionnaire. With a conservative false-discovery rate of 5%, corresponding to an observed nominal p-value of < 0.001, we identified 342 transcripts whose expression levels were significantly correlated with smoking, 110 (32.2%) with positive correlations and 232 (67.8%) negatively correlated. These 342 transcripts correspond to 323 unique genes. Details of this set of genes and the correlation of expression with smoking are provided in Additional File
Validation of the phenotype
A quantitative measure of average cigarettes per day was available in this study, but was deemed less-reliable than the discrete trait, owing to bias introduced by self-report
In addition, plasma cotinine levels were available for a subset (79.1%) of the 1,240 studied individuals. Cotinine is a nicotine metabolite that is often used as a quantitative measure of cigarette smoking; however cotinine levels are subject to both genetic and environmental variation
Functional Annotation Analysis
In order to identify specific pathways and functional assignments involved in the response to smoking, we performed a series of formal pathway analyses. The 342 transcripts meeting the FDR of 0.05 criteria were analyzed using Ingenuity Pathways Analysis (IPA) version 6.3 (Ingenuity® Systems,
Table 1
The most highly significant functional assignments for the set of smoking correlated genes
Function Annotation
Number of genes
Cell cytotoxicity
3.7 × 10-10
Proliferation of cells
2.1 × 10-9
Activation of cells
1.7 × 10-8
Cell movement
2.9 × 10-8
Lysis of cells
1.2 × 10-7
Immune response
2.2 × 10-7
Mobilization of calcium
4.0 × 10-7
Adhesion of cells
7.8 × 10-7
Cell death
1.1 × 10-6
1.2 × 10-6
Binding of cells
2.9 × 10-6
Viral elimination
4.3 × 10-6
4.9 × 10-6
Inflammatory disorder
5.3 × 10-6
Cell growth
5.6 × 10-6
Cardiovascular disorder of lung
1.4 × 10-4
Perturbation of mitochondria
2.7 × 10-4
Inflammatory response
3.4 × 10-4
2.5 × 10-3
Free radical scavenging
3.1 × 10-3
There were several highly significant functional categories involved in various aspects of cell death, including 17 genes involved in cell cytotoxicity (
There were 38 smoking-correlated genes involved in immune response (p = 2.2 × 10-7), including 30 negatively correlated with smoking (
In addition, in the cell proliferation category there were 27 smoking-correlated genes related to lymphocyte proliferation, all but three of which were negatively correlated (p = 5.2 × 10-7). Twenty-one inflammatory response associated genes were significantly correlated with smoking (p = 3.4 × 10-4), including fourteen that were negatively correlated (
There was evidence of overrepresentation of cancer related functional assignments, including 72 smoking-correlated genes that were associated with tumorigenesis (p = 1.2 × 10-6), 23 of which were positively correlated with smoking and 49 negatively correlated genes. There were also 64 genes associated with cancer (p = 4.9 × 10-6), 21 positively correlated with smoking (
In relation to respiratory-relevant pathologies, there were three genes associated with lung related cardiovascular disorder that were all negatively correlated with smoking (
There was also some over-representation of free-radical related functional assignments, including two genes involved in mitochondrial perturbation (
There were five significant canonical pathway categories of smoking correlated genes that also relate well to known smoking pathologies, shown in Table
Table 2
The most highly significant canonical pathway assignments for the set of smoking-correlated genes
Canonical pathway
Number of genes
Natural killer cell signaling
7.9 × 10-7
CTLA4 Signaling in cytotoxic T lymphocytes
1.2 × 10-4
SAPK/JNK signaling
5.7 × 10-3
Xenobiotic metabolism signaling
5.9 × 10-3
Metabolism of xenobiotics by cytochrome P450
9.6 × 10-3
There were ten genes involved in the xenobiotic metabolism signaling pathway in our dataset (p = 5.9 × 10-3), eight negatively correlated (
Network Analysis
There were 243 smoking-correlated genes with known connectivity information from published literature stored in the Ingenuity Knowledge Base. We used this published interaction information to determine whether our smoking-correlated expression signatures are tightly connected at the molecular level. This analysis is therefore restricted to interactions derived from the published literature and does not identify novel interactions between these genes. Network analysis was used to determine whether our smoking-correlated expression signatures are tightly connected at the molecular level, based only on these known interactions, by generating graphical representations of the interactions between genes and/or gene products in our dataset. Network analysis was used to connect 49 of the smoking correlated genes into a single network of gene/gene product interaction (Figure
Figure 1
A gene/gene product interaction network of smoking correlated genes
A gene/gene product interaction network of smoking correlated genes. Networks of gene/gene product interaction were generated using IPA (Ingenuity® Systems,
Genetic and Environmental Correlations of Expression with Smoking Behavior
Observed correlations between smoking behavior and a given gene's expression level may be due to the causal environmental effect of smoking on expression, the shared genetic determinants that jointly influence transcription level and the propensity to smoke, or a combination of these two influences. In order to assess the relative importance of environmental versus genetic sources of phenotypic covariation between expression levels and smoking status, we performed bivariate quantitative genetic analysis to decompose the observed phenotypic correlation of the 50 most significantly correlated transcripts. Because of our large pedigree-based study design, it is possible to directly estimate both the genetic and environmental correlations between expression levels and smoking status. Our results, documented in Additional File
Additional file 2
Bivariate analysis results for the fifty most significant smoking-correlated transcripts. *Indicates there were multiple significant transcripts for this gene.
Click here for file
This study is the largest investigation of gene expression alterations in response to cigarette smoke exposure in human subjects
Peripheral lymphocytes appear to be an excellent surrogate tissue for investigating the effect of smoking on health by transcriptomic epidemiology. Not only are they one of the most readily and easily available tissues for gene expression analysis, they have also been shown to be a good surrogate for other tissue types in the case of environmental exposures, such as cigarette smoke, polyaromatic hydrocarbons and radiation
Lymphocytes may be directly relevant for assessing the damaging effects of cigarette smoke. Thousands of cigarette smoke constituents are rapidly absorbed into the bloodstream, through the pulmonary alveoli, where they rapidly achieve systemic distribution. Oxidative damage and polycyclic hydrocarbon adducts have been readily detected, not only the respiratory epithelium and other first sites of exposure in cigarette smokers, but also in the blood and peripheral lymphocytes
All of the most significant functional groupings of smoking correlated genes identified in this study are directly relevant to well known smoking related disease processes. Cell death and proliferation, immune response, cancer, inflammatory disease and xenobiotic metabolism are all relevant groupings for smoking correlated genes, given known smoking related pathologies. However, the extent of these relevant groupings and the number of correlated genes whose expression is influenced by smoke exposure within each group is striking.
Various aspects of depressed immune function have been well documented in smokers
As mentioned above, the expression levels of eleven genes in the natural killer (NK) cell signaling pathway were negatively correlated with smoking (
Another striking finding of this study was the over-representation of functional groupings relevant to cancer and cancer relevant processes such as cell death, proliferation and signaling. Cigarette smoking is a recognized risk factor for a wide variety of cancers, not only at the sites of contact such as the lungs and esophagus, but also throughout the body such as pancreatic, kidney, colon and bladder cancer. Correlations between expression of genes in lymphocytes and cigarette smoking in this study provide insight into the cancer relevant biological processes occurring throughout the body in response to smoke exposure, and hopefully serve to highlight the complexity of these processes.
We constructed a complex network based on published interaction between genes and/or gene products for 49 of the transcripts that were significantly correlated with smoking (Figure
Although smoking has long-term adverse effects, cessation has some immediate, as well as long-term benefits, which may be due to a reversal of these transcriptomic alterations. Many of the negative health effects have been shown to be reversed or at least improved soon after cessation
This study has some intrinsic limitations that should be noted. The study was conducted in a population of Mexican American individuals and it is difficult to determine what proportion of the expression changes would be replicated in other populations. While results obtained from within a subset of the population may not necessarily be relevant to all subsets of the population, in general it is highly likely that the majority of genes whose expression is altered in Mexican American individuals in response to smoke exposure are the same genes susceptible to alteration in other population groups. Transcriptional alterations are likely more robust to population differences than studies of individual genetic variants. However, a subset of the genes identified in this study may only be relevant to the Mexican American population. It is also important to note that, while not likely, it is possible that cigarette smoking is a surrogate for some other influence that is initiating the transcriptional alterations in this study.
The results of this investigation offer insights into cigarette-smoke related pathological processes by determining its influences at the gene expression level. Never before has such a clear link between smoking and transcriptomics been revealed, and the scale at which exposure to cigarette smoke appears to influence the expression levels of our genes is sobering.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
MCM, LA, JWM, EKM and JB designed and instigated the study including the inception and maintenance of the San Antonio Family Heart Study, phenotype collection and expression profiling. JEC and MPJ conducted the laboratory analyses including the expression profiling. JCC, HHHG, TDD, VPD, JWK, MCM and JB cleaned and/or analyzed the family, phenotype and expression data. JCC conducted the bioinformatic analyses. JCC and JB wrote the manuscript. All authors read and approved the final manuscript.
We wish to acknowledge the Azar and Shepperd families and ChemGenex Pharmaceuticals for supporting the transcriptional profiling, sequencing, genotyping and statistical analysis. The supercomputing facilities used for this work at the AT&T Genomics Computing Center were supported in part by a gift from the SBC Foundation.
Data collection was supported by a grant from the US National Institute for Heart, Lungs and Blood (HL045222). The SOLAR statistical genetics computer package is supported by a grant from the US National Institute of Mental Health (MH059490). The laboratory work was carried out in facilities that were constructed with support from the US National Center for Research Resources (RR013556).
Projections of global mortality and burden of disease from 2002 to 2030
Smoking and cardiovascular function
The Health Consequences of Smoking: A report of the Surgeon General
The epidemiology of smoking: health consequences and benefits of cessation
The health consequences of cigarette smoking. Pulmonary diseases
The health consequences of smoking. Cancer
The health consequences of smoking. Cardiovascular diseases
Tobacco use and its contribution to early cancer mortality with a special emphasis on cigarette smoking
Effects of cigarette smoke on the immune system
Electron spin resonance and spin trap investigation of free radicals in cigarette smoke: development of a quantification procedure
Smokers and passive smokers gene expression profiles: correlation with the DNA oxidation damage
Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
Alteration of gene expression profiles of peripheral mononuclear blood cells by tobacco smoke: implications for periodontal diseases
Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking
Signatures of environmental exposures using peripheral leukocyte gene expression: tobacco smoke
Effects of cigarette smoke on the human airway epithelial cell transcriptome
Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs
Gene expression profiles of T lymphocytes are sensitive to the influence of heavy smoking: a pilot study
Effect of active smoking on the human bronchial epithelium transcriptome
Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
Genetics of atherosclerosis risk factors in Mexican Americans
Statistical tests for detection of misspecified relationships by use of genome-screen data
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
Multipoint quantitative-trait linkage analysis in general pedigrees
Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing
Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results
Apparent underreporting of cigarette consumption among Mexican American smokers
Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine
32P-postlabelling of aromatic DNA adducts in white blood cells and alveolar macrophages of smokers: saturation at high exposures
Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells
Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung
Cigarette smoking induces formation of 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes
A molecular epidemiological case-control study of lung cancer
Effect of smoking on human natural killer cell activity
Immune response in asymptomatic smokers
Immunological findings in cigarette smokers
Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy
Exposure to cigarette tar inhibits ribonucleotide reductase and blocks lymphocyte proliferation
Immunomodulatory effects of cigarette smoke
Cigarette smoke impairs NK cell-dependent tumor immune surveillance
The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation
Immune function in cigarette smokers who quit smoking for 31 days
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
High Plains Underground Archive: Denver Reunion Shows Part 1
40th Day | Irish Rover | The UMS | July 24, 2015
Tom Murphy
The current musical era is not short on nostalgia and reunion shows; bands performing classic albums in their entirety have become commonplace for tours and for the Pitchfork Music Festival. In addition to the "classic rock" nostalgia circuit, many bands who had their heyday in the '50s-'70s seem to embark on reunion tours to demonstrate why anyone cared in the first place.
While not always obvious, Denver and Colorado have produced bands—many no longer active—that have proved influential in the music world at large.As mentioned in a previous High Plains Underground Archive entry on indie pop, The Apples in Stereo and Elephant 6 initiated an important movement whose influence can still be heard in modern pop music. In 2014 Neutral Milk Hotel staged its own reunion tour, performing its 1998 magnum opus In An Aeroplane Over the Sea in its entirety — an album recorded in Denver.
Denver plays host to its share of significant reunion shows, whether for local, formerly local, or out-of-town bands with a connection to the region. Sometimes it's a low-key, one-off show, sometimes the band gets back together for a festival (as Crestfallen did for 2007's Denver Fest), and sometimes the reunion launches a career encore. In the next three weeks, I will share photos of bands at their reunion shows, including features on Warlock Pinchers and The Fluid. Today's entry features Christie Front Drive, 40th Day, Planes Mistaken For Stars, and Sin Desires Marie.
Christie Front Drive made waves well outside of Denver during the late '90s era of emo and math rock.
40th Day proved influential on space rock and dream pop in Denver in the '80s and '90s and reunited in 2013 after a nearly twenty-year hiatus, performing at The UMS in 2015.
Planes Mistaken For Stars brought together people who were part of the '90s punk and emo scene in Denver as well as fans of a hybrid of posthardcore and metal. Known for their raw honesty, compassionate outrage, and the catharsis of their live shows, Planes toured extensively within and outside the U.S.
Sin Desires Marie blended a posthardcore sensibility with a post-punk sound. Starting in the late '90s, SDM made connections with the DC punk world and performed at Ladyfest DC. While not a widely popular band in Denver, SDM represented an era in Denver when riot grrrl and third wave feminism influenced a significant segment of the local punk world. That the band could come back after splitting for eight years and find an audience was not insignificant.
Jimmi Nasi and Neil Satterfield (on right) performing 40th Day songs | Rockbar | February 9, 2012
Tom Murphy
40th Day setlist | Irish Rover | July 24, 2015
Tom Murphy
40th Day | Larimer Lounge | Jul 20, 2013
Tom Murphy
Christie Front Drive | Larimer Lounge | August 28, 2011
Tom Murphy
Christie Front Drive | The Marquis Theater | September 19, 2014
Tom Murphy
Planes Mistaken For Stars | 3 Kings Tavern | August 13, 2011
Tom Murphy
Planes Mistaken For Stars | 3 Kings Tavern | August 13, 2011
Tom Murphy
Planes Mistaken For Stars | The Marquis Theater | July 20, 2014
Tom Murphy
Sin Desires Marie | hi-dive | April 9, 2011
Tom Murphy
Sin Desires Marie | 3 Kings Tavern | UMS | July 20, 2011
Tom Murphy
*Author's Note on the High Plains Underground Archive: In the late 1990s, I started going to local shows on a regular basis. Growing up in the '70s and '80s, I didn't know there was such a thing as local music worth checking out. But I was drawn in after seeing a band called Rainbow Sugar (an all-female punk/hip-hop/experimental guitar rock extravaganza) opening for Sleater-Kinney's first show in Colorado at The Fox Theatre in October 1998. Next, I learned about a show at the now-defunct Rebis Galleries. From there I went to the first Monkey Mania show, and there was no looking back.
Rainbow Sugar was the first local band I photographed at Herman's Hideaway in 1999. But it was in 2005 when I got my first digital camera that my extensive photo archive started. In this series, called High Plains Underground Archive, I will share a small fraction of the tens of thousands of those photos, focusing on specific venues, bands, time periods, movements and whatever else seems to make sense. The title of this series comes from the working title of my book on the history of underground music in Denver 1975 to the present.
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subset: commoncrawl


text:
Changes and Disruptions
The Triad: Chapter 2 . . . Written by Dk64rules (t∣b∣c)
Mikul Corp. - Building 2 Floor 2
11:30 A.M the next day
"Dr. Mikul, sir, what brings you to Building 2?"
"I'm changing your directive, Dr. Dontori. You remember Mr. Halete, right?"
"Yes, the one who made a fool of himself at his interview but you insisted we hire him. What about Halete? Did he finally live up to your little 'hunch' about his skill?" Dontori said, sarcastically.
Dr. Mikul became slightly annoyed. "Why yes he did." Mikul replied confidently. Dr. Dontori's face turned to a shocked, confused expression.
"You're serious? What did he do?"
"He found what my father was looking for all along in starting Mikul Corporation. Halete found a video taken from the alternate reality my father apparently traveled to three times. I originally believed he just went back in time, but...you know what, why don't you see for yourself." Mikul walked past Dontori and pulled up the two videos on the nearest computer. Dr. Dontori stared at the screen as the two surveillance captures played.
"We have the one on the left on file...from 1980, right? And the other one...you have that hanging in your office. What the hell is this?" Dr. Dontori was all sorts of confused.
"The video was taken at the exact same time from the exact same place. The picture I have hanging is from my father's first time travel voyage. There's no doubt about it. Another reality exists. And this particular reality...is the new research focus of Building 1. Get your team up to speed, study these clips, and most importantly, find out where the alternate one came from."
"Will do, sir." Dontori simply replied. He was still sort of in shock over the whole thing.
"Good day." Mikul said, exiting the floor through the elevator.
Altmanti Household
"Dyllan, could you come here for a minute. I need to speak with you." Mr. Altmanti called for his son.
"Yes, Dad?" Dyllan asked.
"The time has come. You remember how to use your...ability, right?"
Dyllan crackled light energy between his hands. "Sure do."
"Dr. Mikul has received a video from what he calls an 'alternate reality.' In this video, there is a monument called the 'Clemethai Stone', which is opened by a few kids. One of the kids, the one who actually is able to open the way into the Clemethai Stone, apparently glows in order to gain access."
"Clemethai Stone? A glowing kid? Alternate reality? Why are you telling me this?"
"I had a dream the day before you were born about the very same kid. A voice told me you would receive the powers of a great light." Dyllan crackled light energy again. "I believe that you and this kid, and the alternate reality as a whole, are connected somehow."
"So, what do I do?"
"Absolutely nothing. Don't use your ability. Don't talk about it. I'll keep Mikul from looking into our family. You make sure no one knows about you."
"Dad...that's actually what I was going to tell you later..."
"I showed somebody."
"I've been dating a girl for two months without you knowing. We have an amazing trust within each other. So, I confided within her my secret. She's totally cool with it."
"Well, I sure as hell am not!! Why in the world would you do that?!"
Peace Key City - City Hall
"Mayor Mount, a word with you please."
"Anything, Mr. Cerato."
"It has come to my attention that you're allowing the Mikul Corporation their request to research into all residents of the city for their so called 'Project Reality.' Care to comment?"
"I firmly believe that they have the right intentions in unraveling what could be the biggest mystery of our time: an alternate reality to our own."
"What will you tell the people to comfort them should they not believe in this 'alternate reality' project?" "If you have nothing to hide, you have nothing to worry about."
"You heard it here first: don't be afraid of the Mikul Corporation. This has been Adam Cerato reporting for Channel Three Nightly News."
The cameramen take the equipment back to the news van outside. Adam sticks around to tell the mayor something in private. "If I were you, I'd watch my back. Wouldn't want the Mikul Corporation digging anything up on you, Mount."
"I've already taken care of it. My documented history was printed and sent to a facility far away from here this morning. The files that it was printed from were terminated, and the hard drive smashed. Mikul will have nothing on me."
"That's good news." Adam looked relieved.
"I'm worried about you, though, Adam. Tell me, is your daughter...seeing anyone?"
"Oh no, Allison is not allowed to date, sir."
"Hmm...that's good. We wouldn't want her secret out there..." Mount looked as though he knew more than Adam did.
"No, sir, we would not want that." Adam concluded. He turned and headed through the city hall doors. They closed with a thud behind him.
"Better call Altmanti..." Mount said to himself.
1 . 2 . 3 . 4 . 5 . 6 . 7 . 8 . 9 . 10


text:
SPRINGFIELD, Ohio – In "Perilous Times Shall Come: A Fictional Novel on the End Times" (published by WestBow Press), former police officer Dan Winters must sift through the chaos of government cover-ups, secret societies and UFOs to get to the truth of the rapture.
Though a work of fiction, author Dr. Arv Edgeworth hopes to present a true picture of how events will transpire in the end times. In the novel, Dan comes to realize that UFO sightings are a product of Satan's deception; the UFOs controlled by so-called aliens are actually demons and fallen angels.
Edgeworth notes that UFO sightings and the use of microchip technology are signs leading up to a one-world government, which will set the stage "for the coming scene of the Anti-Christ."
He explains, "We are nearing the Lord's return. How will the use of microchip technology fit in with the Mark of the Beast? Are there things our government isn't telling us. I want people to know about a lot of things that are going on in our world that most people would be unaware of."


text:
Montgomery finishes off Yankees' no-hitter
Left-hander fires four perfect frames as New York blanks host Tigers
By MiLB.com | March 17, 2017 4:52 PM ET
Yankees 3, Tigers 0 (Box)
Yankees No. 13 prospect Jordan Montgomery threw four perfect innings to close out a no-hitter at Joker Marchant Stadium as New York posted its Major League-best 16th Spring Training win. The 24-year-old left-hander struck out two after starter Masahiro Tanaka and Chasen Shreve held Detroit hitless over the first five frames. It marked the Yankees' first Spring Training no-hitter since 1983 and earned Montgomery some points with manager Joe Girardi -- MLB.com's Bryan Hoch reported after the game that Montgomery is expected to start at least one Spring Training game. Yankees No. 12 prospect Tyler Wade went 1-for-2.
Mariners (ss) 5, Dodgers (ss) 2 (Box)
Mariners No. 2 prospect Tyler O'Neill had two hits, including a long two-run homer off Clayton Kershaw, and also threw out a runner at the plate. No. 6 prospect Max Povse worked four innings of scoreless relief, allowing three hits and striking out three. The 23-year-old right-hander has not given up a run in 10 innings in Cactus League play.
Twins 4, Rays 2 (Box)
Rays No. 4 prospect Jake Bauers belted a solo homer, his third long ball of the spring, and walked in the loss. The 21-year-old outfielder is hitting .435 with eight RBIs in 12 Grapefruit League games. Daniel Robertson (No. 17) was 0-for-2. Twins No. 11 prospect J.T. Chargois gave up two runs -- one earned -- on two hits with one strikeout in 1 2/3 innings. Daniel Palka (No. 14), Mitch Garver (No. 15) and Zack Granite (No. 22) each went 0-for-1.
Orioles 8, Pirates 6 (Box)
Orioles No. 5 prospect Trey Mancini smacked a solo homer and scored twice as Baltimore outlasted the Pirates in Bradenton. Mancini is batting .351 with a pair of long balls this spring. Top O's prospect Chance Sisco singled and drove in a run. For the Pirates, infielder Alen Hanson (No. 17) raised his Grapefruit League average to .379 after going 3-for-5 with a double. Outfielder Austin Meadows (the Bucs' No. 2 prospect) went 2-for-5, while Max Moroff (No. 26) singled.
Mets 16, Cardinals 2 (Box)
No. 5 prospect Harrison Bader had two of St. Louis' seven hits in a blowout loss to the Mets. Luke Weaver, the Cardinals third-ranked prospect, was charged with four runs on three hits and four walks over 1 1/3 innings in relief of Adam Wainwright.
Astros (ss) 5, Braves 4 (Box)
No. 2 Braves prospect Ozzie Albies got the start at second base and went 1-for-2 with a walk out of the leadoff spot, raising his average to .364. Rio Ruiz (No. 23) was 2-for-2 with a pair of RBIs, while Adam Walker, claimed off waivers from the Orioles in January, slugged a solo homer. Austin Riley (No. 13) struck out in his only at-bat. No. 4 Astros prospect Derek Fisher doubled and drove in three runs, while Colin Moran (No. 25) was 2-for-4 with a run scored. Kyle Tucker, Houston's No. 2 prospect, made his Spring Training debut as a late-game replacement in right field and flied out in his only at-bat. Jandel Gustave (No. 20) tossed a perfect inning out the bullpen, lowering his ERA to 1.50 in six outings.
Astros 6, Red Sox 2 (Box)
Houston's top prospect, right-hander Francis Martes, struck out three over three perfect innings. No. 7 prospect Teoscar Hernandez went 2-for-5 with an RBI double and two runs scored and No. 13 prospect J.D. Davis also had two hits, including an RBI double. No. 4 Red Sox prospect Sam Travis had an RBI single, No. 19 prospect Ben Taylor struck out three over 1 2/3 hitless innings and 30th-ranked prospect Robby Scott allowed one hit and one walk in a scoreless frame, striking out one.
Marlins 5, Nationals 5 (Box)
No. 9 Miami prospect Drew Steckenrider fired a perfect ninth inning and 20th-ranked Tayron Guerrero struck out two in a scoreless frame, despite issuing three walks. No. 29 prospect Tomas Telis singled in three at-bats.
Cubs 7, White Sox 3 (Box)
The reigning World Series champions bested the South Siders, but the most notable performance may have been by White Sox No. 3 prospect Michael Kopech. The 20-year-old right-hander struck out five while allowing one hit over two scoreless frames and was reportedly hitting triple digits with his fastball. It was easily the best performance of the spring for Kopech, who had allowed five runs on six hits in four previous innings. Top White Sox prospect Yoan Moncada singled and scored in his lone at-bat, while prospects Ian Happ (No. 2) and Jeimer Candelario (No. 5) went hitless for the Cubs.
Rangers (ss) 6, Angels 5 (Box)
Fifth-ranked Texas prospect Ronald Guzman smacked a go-ahead three-run homer in the seventh inning for his first dinger of the spring. Angels No. 8 prospect Alex Meyer allowed a run on four hits and a walk while fanning two over three innings in the losing effort.
Mariners (ss) 9, D-backs (ss) 5 (Box)
Second-ranked Arizona prospect Domingo Leyba collected two singles and drove in a run, while No. 17 prospect Matt Koch held Seattle to one hit while fanning two in innings of scoreless relief.
D-backs (ss) 3, Athletics 2 (Box)
A's top prospect Franklin Barreto and No. 4 prospect Matt Chapman both singled. Hitting .481 with a homer and four RBIs this spring, Barreto was assigned to Triple-A Nashville after the game.
Royals 8, Brewers 5 (Box)
Ryan O'Hearn, Kansas City's No. 8 prospect, doubled twice, scored twice and drove in a run in four at-bats. Brewers No. 7 prospect Lucas Erceg singled in three at-bats.
Rockies 5, Giants 1 (Box)
Raimel Tapia, Colorado's fifth-ranked prospect, hit an RBI triple and scored a run, while No. 20 prospect Jordan Patterson went 2-for-3 with a run scored. In his first Cactus League start, No. 28 prospect Harrison Musgrave yielded one hit and struck out two over three scoreless innings.
Indians (ss) 3, Rangers (ss) 2 (Box)
Indians No. 25 prospect Shawn Armstrong continued his strong Cactus League play, allowing a hit and a walk with four strikeouts in two innings. The 26-year-old has fanned 10 over 8 1/3 scoreless frames this spring. Josh Morgan, Texas' 13th-ranked prospect, singled twice in three at-bats.
Reds 7, Indians (ss) 3 (Box)
Bradley Zimmer, Cleveland's top prospect, singled twice and stole his third base of the spring. MLB.com's No. 22 overall prospect is hitting .372 with two homers and a team-leading 11 RBIs in 17 games. Tenth-ranked prospect Yandy Diaz stroked an RBI single and scored a run for the Indians, while Reds No. 30 prospect Sebastian Elizalde had an RBI double and scored a run.
Dodgers (ss) 2, Padres 3 (Box)
Hunter Renfroe, the Padres' third-ranked prospect, went 2-for-4 with a double, an RBI and a run scored, while No. 23 prospect Jose Torres struck out the side in the ninth to pick up the win. The 23-year-old southpaw has allowed one hit and one walk while fanning nine over six scoreless innings this spring.
This story was not subject to the approval of the National Association of Professional Baseball Leagues or its clubs.View More


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text: Camila Domonoske CDC: Half Of All Female Murder Victims Are Killed By Intimate Partners By Camila Domonoske • 1 hour ago More than half of female murder victims were killed in connection to intimate partner violence — and in 10 percent of those cases, violence shortly before the murder might have provided an opportunity for intervention. That's according to a new report from the Centers for Disease Control, published Thursday, that takes a close look at the homicides of women. Fear And Fury In Venezuela, As Strike Protesting 'Dictatorship' Begins By Camila Domonoske • Jul 20, 2017 Empty streets, makeshift barricades, burning tires, signs scrawled with "No to dictatorship": Protests continue on the streets of Venezuela as a 24-hour general strike takes hold, the latest development in an ongoing political and economic crisis. Some citizens are trying to go to work despite the shutdown of public transportation; others are taking to blockaded streets in protest. There is widespread fear of more bloodshed after months of conflict and dozens of deaths. Moon Dust Bag, Accidentally In Private Hands, Auctioned For $1.5 Million By Camila Domonoske • Jul 20, 2017 Updated at 2:45 p.m. ET A small, humble-looking bag received its moment in the spotlight today. It traveled to the moon and back, then sat forgotten in a museum basement. It was seized by officials who didn't know its value, sold unceremoniously to a keen-eyed space enthusiast, then battled over in court. Then the lunar collection bag from the Apollo 11 mission — and the tiny bits of moon dust embedded within it — hit the Sotheby's auction block. In Poland, Effort To Take Control Of The Courts Inspires Protests By Camila Domonoske • Jul 19, 2017 As Poland's ruling party moves to take control of the country's high court, protesters are taking to the streets and European Union officials are warning of the possibility of sanctions. There is fear, both within and outside of Poland, that a proposed measure would upend an already-weakened system of checks and balances. BBC Salaries Ignite Debate Over Appropriate Pay, Gender Equity By Camila Domonoske • Jul 19, 2017 The BBC has released salary information for its on-air talent for the first time, igniting simultaneous debates over the size, and the fairness, of the salaries — particularly over a conspicuous gender gap. The public broadcaster has always included executive salaries in its annual report*. But this year, the government required the public broadcaster to reveal what the highest-paying presenters and actors make, too. The resulting list includes approximate salary ranges for all 96 radio and TV staff making more than $195,000 a year. Pages1 2 3 4 … next › last »


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As the economy increasingly moves towards a knowledge based economy, the ability to manage knowledge becomes a matter of competitive survival. Many other books only address the subject only partially, from a human resource, information systems or practitioner perspective. This is the first textbook to bring together and integrate all these dimensions.
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Close to train station
Jalan Marjuk no. 4-6, Bandung T: (022) 420 7850 F: (022) 426 0427
The main reason for choosing to stay at Hotel Serena is for its proximity to the train station, its genuine hotel feel and the value for money on offer.
Last updated on 17th July, 2012.
The Travelfish newsletter is sent out every Monday and is jammed full of free advice for travel in Southeast Asia. You can see past issues here.


text: On Fri, Jan 07, 2005 at 02:09:46PM -0500, Gene C. wrote: > On Friday 07 January 2005 13:07, Dave Jones wrote: > > As a heads-up, todays rawhide has an extra debugging check that > > checks those memory allocations periodically. This should catch > > stuff that stomps past the end of its allocation, but never > > free's it. Hopefully it won't turn up anything new, but it's > > worth having it on for now just for a look-see.. > > I am having some problems of apparent conflicts between USB (mouse) and acpi > [this is already bugzilla'ed] and was wondering if the new kernel in rawhide > might fix the problem. I am currently running FC3 with all available updates > applied. Is there any problem running the rawhide kernel in such a system > (other than any problems the kernel itself might have)? Rawhide is currently based on 2.6.10-bk9, updates-testing has a 2.6.10-ac3 kernel (soon to be ac6). At this moment, I'd have more faith that the -ac kernel is going to prove more solid. Dave


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Search results for: aca ams sma cur
Showing items 1 through 9 of 61.
Department of Applied Military Science (AMS)
Score: 0.2483488 - URL: http://www.rmcc-cmrc.ca/en/applied-military-science/department-applied-military-science-ams
About the Department of Applied Military Science
Military College of Canada PO Box 17000, Station Forces Kingston, Ontario CANADA K7K 7B4 AMS-SMA ... The Department of Applied Military Science (AMS) in Kingston, Ontario is a component of the Royal ... mandate, AMS offers two programmes, the Army Technical Staff Officer Programme (ATSOP), and the Army ...
Score: 0.24573584 - URL: http://www.rmcc-cmrc.ca/en/applied-military-science/about-department-applied-military-science
Contact Us- Department of Applied Military Science
-6000 ext 3812, 3901 or 6163 Fax: (613) 541-6160 E-mail: firstname.lastname@example.com Staff Hall, Stephen, Colonel ...
Score: 0.18745464 - URL: http://www.rmcc-cmrc.ca/en/applied-military-science/contact-us-department-applied-military-science
Courses- Department of Applied Military Science
These are the courses delivered on the ATSOP and ATWOP. Course Code Course Name AMS 101 Applied ... Mathematics AMS 103 Applied Physics AMS 105 Applied Chemistry AMS 107 Military Materials AMS 500 Research ... Project AMS 501 Military Communications Systems AMS 503 Military Information Systems AMS 505 Battlefield ...
Score: 0.14479905 - URL: http://www.rmcc-cmrc.ca/en/applied-military-science/courses-department-applied-military-science
Canada AM Puts the Spotlight on Kingston's Military Roots
By: Lt(N) H. Mooney, CFB Kingston Public Affairs BGen Meinzinger speaks to Canada AM hosts Beverly ... of RMC, joined the hosts of Canada AM in the city hall courtyard for a discussion about the base, RMC ... . The RMC Band puts on a show for the audience of the special Kingston edition of Canada AM. Two Griffons ...
Score: 0.12181049 - URL: http://www.rmcc-cmrc.ca/en/canada-am-puts-spotlight-kingstons-military-roots
Media- Department of Applied Military Science
The AMS advantage: A key enabler of success in the modern operating environment By Suzanne Lebeau ... of Applied Military Science (AMS) is a department of the Royal Military College and its primary purpose ... in the capability development process. To meet its mandate, AMS offers three programs, the Land Force Technical ...
Score: 0.11487182 - URL: http://www.rmcc-cmrc.ca/en/applied-military-science/media-department-applied-military-science
Location and Facilities- Department of Applied Military Science
of the Royal Military College of Canada. The AMS Department is housed in a separate facility with a 32 ... rooms are linked to the RMC network and the Internet. AMS staff and students regularly use RMCC ...
Score: 0.062638685 - URL: http://www.rmcc-cmrc.ca/en/applied-military-science/location-and-facilities-department-applied-military-science
Reunion Weekend 2016
September 10:00am- 12:00pm: Badging Parade, Parade Square 12:00pm- 1:30pm: Ex-Cadet and Old Brigade Luncheon ... , Currie Hall Sunday, 25 September 10:30am – 11:30am: Memorial Arch Ceremony, Memorial Arch/Parade Square ...
Score: 0.057537306 - URL: http://www.rmcc-cmrc.ca/en/college-commandants-office/reunion-weekend-2016
MathSciNet English English-only http://www.ams.org/mathscinet Private MathSciNet is a database ...
Score: 0.04429224 - URL: http://www.rmcc-cmrc.ca/en/node/5141
Dynamics, Control, Robotics, Guidance and Navigation
-rheological dampers, and the analysis and control of shape memory alloy (SMA) based robotic actuators (artificial ...
Score: 0.0396268 - URL: http://www.rmcc-cmrc.ca/en/mechanical-and-aerospace-engineering/dynamics-control-robotics-guidance-and-navigation


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ANAHEIM, Calif. (AP) The Anaheim Ducks placed backup goaltender Ilya Bryzgalov on waivers Friday and recalled Jonas Hiller from the Portland Pirates of the AHL.
If no team claims the 27-year-old Bryzgalov, he'll be sent to Portland.
Bryzgalov, the backup to Jean-Sebastien Giguere, appeared in nine games this season. He was 2-3-1 with a 2.55 goals-against average and a .909 save percentage.
The 25-year-old Hiller played in two games for the Ducks this season, going 1-1 with a 3.03 goals-against average and an .885 save percentage. He won his NHL debut, stopping 22 of 23 shots in Anaheim's 4-1 victory over the Los Angeles Kings on Sept. 30 in London.
Hiller, a native of Switzerland, has also played in six games for Portland this season, going 3-2-1 with a 2.11 goals-against average and a .929 save percentage. He was signed as a free agent last May after spending the 2006-07 season with Davos of the Swiss National League.
The Ducks made Bryzgalov the 44th overall selection in the 2000 NHL draft. He appeared in 69 games with the Ducks, including a career-high 31 in the 2005-06 season, and has a 26-23 record with a 2.48 goals-against average.
Bryzgalov played in 11 games during the 2005-06 playoffs, going 6-4 with a 1.46 goals-against average.
Copyright 2007 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Conversation guidelines: USA TODAY welcomes your thoughts, stories and information related to this article. Please stay on topic and be respectful of others. Keep the conversation appropriate for interested readers across the map.


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The maximum direful break is forthcoming upon us soon, men. The nightmare other proverbial as the Christmas buying season is barely complete and other chilling day is conscionable a lesser more than a period of time away, Valentine's Day. Just intelligent roughly speaking that vacation and all it's toy bears holding rose-pink short whist breaks me into a bitter perspiration.
There are abundance of websites devoted to the subject while others are near for your purchasing desires. Some women's magazines run aggregate stories on the question in hopes that the girlfriends will influence or subtly glob hints to their meaningful others.
While I am not a writer for Cosmo or Maxim, I have unfashionable some poverty-stricken girls and have a lot of women friends and they all excess Valentine's Day as if it were the 2d peak vital day of the yr. Their birthday's state the furthermost.
So here goes zip. Here is my inventory of 10 gifts a man can get a female for Valentine's Day:
- Music - For the bankrupt man, a rhyme mix mightiness win you many points. It strength demand a bantam bit of tough grind going through with your auditory communication catalogue or downloading songs she strength like, BUT it truly won't cost you more than than $10. Some of these songs can be expensive set the boulevard too. If you ever get into an storm or face-off those songs which have now turn "our" songs in your affinity will e'er be a anamnesis of what you two allocation. It shows you are sensible and you not apprehensive to viewing your easily upset side depending on the poem test.
- Flowers - They effort as a standalone gift ONLY if it's a new relation. If you're in a understanding that's even semi-involved chew over flowers an add-on necessity. Different colours of roses all have divers meanings so formerly you conscionable charge that xii roses, you larger do your homework freshman. Find out what display place of the relation you possibly will be in and what lap she thinks you are in.
- Chocolate - Let's obverse it. Women LOVE chocolate like we esteem beer and way. I was former threatened with book of force by two women co-workers from a former job of excavation because I forgot to harvest to up a CHOCOLATE BAR on my way to pursue one antemeridian. They were overmuch smaller than me but at that instant in time, I was scared for my go.
- A doll take on holding a box of chocolates - It's cliché. I cognise but if it isn't broke, next why fix it? Apparently it industrial plant. Plus it involves cocoa once again. Go beside it.
- Sexy underclothes or underwear - This is a gamble. I've never been heroic ample to try this. I don't cognize if it's because I was e'er frightened of the girl's allergic reaction any from buying the inaccurate volume and implying she's fat or overstepping boundaries in a new affinity. It's a bad stake with a big latent payout.
- Clothes - This can be untrusty as symptomless with the buying-the-wrong-size complication but otherwise than that it's a beautiful locked and trouble-free way to go. It can be shoddy or it can be pricey. You have a lot of legroom to hard work next to in this category from tank to sweaters to coats. Clothes are too the easiest entity to revisit from this unbroken enumerate.
- Pets - Puppies and kittens form adorable gifts. Be definite that your woman is judicious adequate to payoff thought of it in spite of this. The finishing state of affairs you genuinely want is for YOU to be the one attractive the whelp out for a "walk" in the precipitation or cleaning a muddy litter box. Bad modern world.
- Jewelry - Old Reliable. How can you go inaccurate near jewelry? It's moderately well in reality. Personally, I don't know what the part I'm doing once it comes to adornment. I with the sole purpose recently recovered out that here is a big inconsistency concerning a root and a unit.
- Spa Package - It's reposeful. It's incident for her have a number of "me-time" and occurrence for you to get a number of distant event or mathematical sports bar near the boys clip which is never a bad state of affairs.
- Romantic Getaway - Next to perhaps the aroused lingerie, this is the gift you can relish too. Plan a humanities getaway location nice for vindicatory the two of you. It can be a time period skiing trip, a expedition to the beach, or mayhap a voyage. Whatever you choose, you win. You outer shell resembling a leader for golf stroke the mental object and stab into preparation the voyage positive you get to pickup for a few years. There it is. The least definitive catalogue of suggestions put out on the web today. Please don't reckon me an consultant. If you've seen my line record, you would see why. If a person else has any separate suggestions, gratify grain pardon to transmit them. I would greatly acknowledge it. You'll be small indefinite amount out assign of guys this year as asymptomatic as myself.


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The equipment option ConnectedDrive Services Professional forms the basis for the BMW ConnectedDrive functions, which provide the driver with a wide range of information, entertainment and service features while on the road.
These include BMW Online, which gives you access to current, localized information such as weather, news, and online search. It is also possible to access popular services such as Yelp, Google Street View and Panoramio.
This option also includes secure and unlimited access to smartphone apps such as BMW Connected. You will find lots of other useful apps and more are added every day.
With the BMW Laptimer app, driving data from the racecourse can be precisely recorded and an analysis can be carried out for improving driving-performance. The recorded information, which falls into categories such as accelerator pedal, steering angle, G-force and best lap time, can be posted as snapshots to Facebook or Twitter, or sent by email.
For anyone who has ever wanted to know what it is like to have their own personal butler, here is the chance: with Concierge Services from BMW ConnectedDrive. Concierge Services offers a personal assistant, via the BMW Response Centre, to help find points of interest. Destinations could include; restaurants, shops, hotels, or even a specific address. The agent can also send these destinations directly to the vehicle's navigation system. Concierge Services operates independently of the driver's mobile phone and is available at home and abroad, around the clock, seven days a week. ConnectedDrive Services Professional is required in order to use this function.
Advanced Real Time Traffic Information (ARTTI) provides the most up-to-date traffic information at all times. Precise details of the time and duration of hold-ups are relayed virtually in real time. The data is drawn from such sources as movement profiles from the mobile phone network, the GPS data of vehicle fleets, smartphone apps and police reports. This data is analyzed so precisely that it is possible to localize traffic congestion to the nearest few metres. This enables ARTTI to provide information in real time on the current traffic situation on motorways, main roads, country roads and numerous urban routes. ARTTI is only available in conjunction with ConnectedDrive Services Professional and BMW Navigation System Professional.
BMW Assist Emergency Call permits fast, targeted assistance round-the-clock, supported by trained staff. If a serious accident takes place involving activation of an air bag or the belt tensioners, a BMW Assist Emergency Call is automatically issued. Relevant details such as the exact position of the car, the severity of the accident, and the possible risk of injury to occupants are transmitted to the BMW Call Centre via the car's built-in SIM card, i.e. independently of a private mobile phone. The BMW Call Centre will inform the nearest rescue coordination centre and provide assistance over the phone until rescue services arrive. The emergency call can also be triggered manually in case others on the road require help.
Bluetooth Office allows you to use time spent in the car more effectively. Via Bluetooth-enabled devices, daily work can be conveniently organised while on the go. The most important office functions of specified smartphones, such as e-mails, appointments, tasks or text messages, are shown on the Control Display and can also be read aloud on demand conveniently and securely over the audio speakers.
The equipment option Internet gives web access on the car's Control Display. The URL is entered simply and conveniently using the iDrive Controller or using the bookmark list for fast access.
With unlimited data for internet use, one can surf the internet directly from their BMW nationwide (no roaming). The Control Display can be used for web surfing only while stationary. ConnectedDrive Services Professional is required in order to use this function.


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Finished Project: Cropped Cat Scout Tee
by Janice
I finished this cropped Scout tee a few weeks ago and only had a chance to write about it now. I've made the Scout tee many times, so adjusting this one didn't go too badly. I cut a size 4, drafted pockets from a Uniqlo cropped tee that I owned, made the sleeves longer, and made it cropped. I used a stiff Alexander Henry quilting fabric because I loved the cat print.
I still haven't worn this much since I have no idea how to style it, but it's definitely comfortable.


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The regulators of the Dubai International Financial Center and the Abu Dhabi Global Market have agreed to support each other on enforcing international financial market regulations.
Ian Johnston, the Chief Executive of the DIFC's regulator, the Dubai Financial Services Authority, said: "As regulators of financial centers founded on Common Law principles, we embrace best practice and apply regulation which meets the requirements of the international standard-setters: the Basel Committee on Banking Supervision; the International Organisation of Securities Commissions; the International Association of Insurance Supervisors; and the Financial Action Task Force. Signing this MoU demonstrates a mutual willingness to co-operate and share information to those standards."
"The importance of effective co-ordination and co-operation between regulators cannot be overstated and to that end the DFSA has concluded some 97 MoUs with its counterparts since our establishment in 2004."
The DIFC and the ADGM offer a number of tax advantages to investors, including exemption for taxes guaranteed for 50 years and allow 100 percent foreign ownership.
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Is your virtualization strategy delivering the expected cost and efficiency savings?
FrontRange DSM automates the management of hosted virtual desktops so you can reap the cost-saving benefits of this breakthrough technology. To realize the benefits of Hosted Virtual Desktops, you need a solid imaging strategy.
Rather than relying on fixed images, FrontRange uses a more flexible building block approach to help keep your environment in sync. No need to rebuild the image over and over again. Simply update the master by assigning packages for patches or other software. FrontRange DSM can help you standardize and automate your virtual desktop infrastructure.
Hosted Virtual Desktop management. It's just another way FrontRange is helping you get a handle on the next generation of client computing.
*Source: Gartner, Forecast: Hosted Virtual Desktops, Worldwide, 2010-2014 (2010 Update), Ranjit Atwal, December 2010.


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Conveniently located near to the interchange of the I-295 and Butler Boulevard, this business center is close to the heart of Florida's largest city. Jacksonville has its own international airport, just 15 minutes from the downtown area, and Amtrak also serves the city with daily long-distance trains. The city's economy is strong because of its diverse range of businesses including financial services, biotech and manufacturing, and the HQs of several Fortune 500 companies are based here. National surveys have ranked Jacksonville as one of the top US cities to relocate to for employment opportunities. The city is also home to many higher education institutions, including the University of North Florida. The deep-water port of Jacksonville is Florida's third largest and serves both military and civilian needs.
4 options available, from one month to years.
Prices are per person per day.
To arrange a visit, speak to our team on 1-855-400-3575
Whatever your business, whatever your budget we'll help find the right workspace.
Whatever your business, whatever your budget we'll help find the right workspace.
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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Flooring Specialist
Added 28/06/2013
We have the carpet (its 3 years old and precut to another room shape). We would like to carpet...
Flooring Specialist
Added 28/05/2012
The floor under my carpet seems to be "sinking" and the "hole" seems to be getting larger.
Flooring Specialist
Added 14/01/2012
To fit a hessian backed carpet (and underlay) to a 4m x 4.5m bedroom carpet and underlay I'm...
Flooring Specialist
Added 03/08/2011
fit carpet already bought 4m by 5m in lounge. Gripper rod and unerlay alredy in place
Flooring Specialist
Added 29/03/2011
I need someone to fit lino for me the kitchen is 10' by 9'
Very good hard woker good job I will use him if do any more work
I now have an outdoor space I not only can use, but love.Ken gave me excellent advice on what would work and I am more than thrilled with the results. Rose
If you are looking for honest, hard-working, reliable tradesmen, these are your guys. Floor preparation was unparalleled - after 4 previous floor disasters, I've got a good understanding of how this all works. To ensure a level floor, they ground down high bits and used a self-leveller to bring up the low bits. They worked late when necessary to get it finished in time - and I mean late - 10 or 11pm. They cleaned up after themselves and we had a team here every day until the job was complete. Excellent job!
Managing your job is easier with the Rated People Homes App, download it today.


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Hello podders, and welcome to the latest edition of Music Weekly. In today's show, we kick things off with a word in your ear from Underworld's Karl Hyde. The guys are back with a new album, Barking, and Hyde explains to Alexis how Underworld have stayed together through a combination of love and sheer bloody-mindedness. He's also got a few kind words to say about the wonders of Essex.
On Singles Club, Alexis is joined by Rosie Swash and the Observer's Caspar Llewellyn Smith to listen to Seahawk's High Seas Drifter, Zola Jesus's Sea Talk and the recently rereleased Enter the Ninja, by South African "Zeffers" Die Antwoord. Finally, we hear from Ikonika (aka Sara Abdel-Hamid) on being embraced by the dubstep community and why she loves her female fans.
That's all for this week, come and find us on Twitter or Facebook should you so wish. Until next time, enjoy!


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Laura in North Pole, Alaska
92 months ago
I am with a company (For Every Home) that has a great fundraiser! I want to get my name out and help organizations earn money. I have done the research and found we honestly do give more. 51% of all sales goes to the organization. It doesnt matter how big or small you are or your cause you can make some money for your needs!Anyway, my question is where is there a website to find groups seeking fundraisers.thanks
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We would like to propose a model that may confer simplicity, consistency, and moral clarity to end-of-life issues facing physicians and their patients.
From a Darwinian perspective, suicide at first glance seems an aberration, since the goal of the evolutionary game is to live in order to pass on one's genes. If one reflects further, however, it may be that suicide has evolved as a way for a damaged organism to cease being a drain on resources that could otherwise be used by its offspring or kin, which share its genes in varying degrees. The desire to die arising from the perception of being severely damaged physically or mentally may have made sense in times past from an evolutionary perspective. Arguably, it does not make sense in today's society, with its social safety nets and medical advances.
Niculescu AB. The Will to Live, Suicide, and Euthanasia. Arch Intern Med. 2000;160(11):1706. doi:
© 2017


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Availability: This product is currently out of stock.
Hunt down rebels in Capital City with the walking AT-DP ! Patrol the streets of Capital City in the twin-legged 75083 LEGO Star Wars AT-DP military walker! Rebels have been reported in the area, so jump into the cockpit, close the hatch, load the twin spr
Warning: prices, links and product specifications for Lego 75083 AT-DP are submitted by our listed stores. Please notify us if you find any errors.
Search hundreds of online stores that deliver to Sydney, Brisbane, Melbourne, Canberra, Perth, and all over Australia and find the best offers for Lego 75083 AT-DP toy. Only on ShopMania you can find the lowest Lego 75083 AT-DP prices available, learn about the latest discounts and compare toys deals. Here you can browse through the Lego 75083 AT-DP photo gallery, find out all about its features and specs and read the product reviews and user comments from our community.
Lego 75083 AT DP - Similar searches: Lego 75083 AT DP, Lego 75083 ATDP, 75083AT-DP


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New information has emerged indicating the UK government's involvement in the planning of a military raid turned massacre on a Sikh temple in Amritsar almost three decades ago.
The fact that the UK had a hand in one of the most tragic events in Sikh history has opened old wounds for the community all over the world.
In 1984, Operation Blue Star took place in the most sacred of Sikh shrines - the Golden Temple - to flush out Sikh separatists who had taken refuge there. The raid turned violent and thousands of pilgrims lost their lives.
The Indian government counts the loss in hundreds but the Sikh community holds it to be in thousands.
Reactions to the incident plunged the entire country into violence – the worst in the country's recent history.
According to Tom Watson, a member of the British Parliament, secret documents from National Archives reveal how Margaret Thatcher's government advised their Indian counterparts on the Sikh separatists at the temple.
This development is also likely to refresh painful memories of the Jallianwala Bagh massacre of 1919, which occurred on the occasion of Baisakhi, a major Sikh festival. On that fateful occasion, British troops ruthlessly cut down hundreds of men, women and children that had gathered for a peaceful protest in Amritsar.
Radical Sikh organization Dal Khalsa has written to British Prime Minister David Cameron expressing its "pain, concern and anguish over the startling revelations as to how the then British government under Margaret Thatcher helped Indian government to attack the Golden Temple in June 1984".
Spokesperson for the organization, Kanwar Pal Singh, said, "the news report about the secret document from British National Archives revealing the UK government collaborating with the Indian government to plan the attack has shattered the Sikhs from within. The Sikh diaspora is deeply hurt and the news has left them numbed."
Several Sikh organizations have called for a rally outside the British High Commissioner's office in New Delhi on January 17th.
One of India's largest political parties, Bharatiya Janata Party (BJP), asked its government for an explanation.
"It is about time that the Government of India decided to tell us the truth as to what the real facts were. This would enable the people of India to conclude whether 'Operation Blue Star' was a strategic miscalculation," said BJP leader Arun Jaitley.
Cameron has ordered an investigation into the matter.
However, Lt Gen Kuldeep Singh Brar, the Indian general in charge of the raid on the Golden Temple, has dismissed claims that the UK conspired in the operation.
"I am dumbfounded and totally amazed," he said. "I do not believe that these documents could be authentic.
As far as I am concerned the operation was planned and executed entirely by military commanders of the Indian army.
There was no question of our getting help or advice from any foreign country - and certainly not from Britain - so as far as I am concerned [these allegations] appear to be like fiction," he added.


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Shivaratri opens hearts, energizes followers of all faiths
February 28, 2013
Spring is in the air and Easter and Passover are on the horizon, but as many western beliefs prepare to usher in the season with well-known holidays, more than a handful of Nevada County residents will take time in early March to celebrate the Night of Lord Shiva, or Maha Shivaratri, an ancient Hindu holiday.
Usually celebrated in February, the gathering to honor Lord Shiva varies according to the Hindu calendar, taking place on the dark night of a new moon. This year the celebration occurs March 10.
Wild Mountain Yoga will mark the holiday with an evening of chanting, reading, meditation, fasting and devotional song.
Shivaratri essentially honors and glorifies the Hindu god Shiva, the lord of destruction, and while Robert Kelaghan notes that a myriad of myths and symbolic stories surround the holiday's history, as with any ancient holidays, he stresses people come primarily to take part in a heart-opening experience.
"It's something that appeals to people who are drawn to meditation, yoga, and eastern philosophies," Kelaghan, who will co-host the evening and lead chants with Bhakti Bliss, said. "This is a major holiday in India – they don't do anything halfway. Their celebrations go all night. I've done a few of them and they're incredibly powerful. You may get tired but you get boosted by readings or music. They're incredibly energizing."
The Wild Mountain Yoga gathering goes from 6 p.m. to midnight and includes puja (a ritual opening the space to the energy) and a meditation at the end of the evening.
According to Kelaghan, the crowd thins out as the evening goes on and the fasting is optional. He is also a strong believer in the power and importance of chanting, an integral part of the celebration.
"I feel like chanting is just about to come into the mainstream, just like yoga did in the '60s and ' 70s," he said. "There are festivals in America, three- and four-day festivals, that are just chanting, and the musicians that lead these chants sell millions of records.
"It's stacked against us, we're a pretty fast-paced society. The whole idea of chanting is like meditation, but it adds music. Good music, good chanting, opens the heart. You have a phrase you repeat over and over, deeper and deeper, and the mind slows and lets go of stressful thoughts, and your mind finds peace."
Amanda Dozal, owner of Wild Mountain Yoga, points out that while Shiva was known as a destroyer, the prominent theme of the gathering is recognizing that everything occurs in phases.
"No matter what, everything finishes its cycle. The only reason we have Shiva is to finish these cycles, so we can start new again. It's the recognition of the cycle of life," she added.
Dozal also notes that people of all faiths take part in the celebration and that about half are familiar with Shivaratri. Some attendees are shiva or yoga devotees, but many aren't familiar with the holiday and simply want to be part of the evening by getting together and praying through mantra, chanting and song.
The Night of Lord Shiva is open to the public at no charge, however donations are welcome. For more information, go to http://www.wildmtyoga.com or call 530-265-4072.
Katrina Paz is a freelance writer in Grass Valley.
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Tucked away behind a Chervon gas station off Rio Road in Carmel, the Carmel Mission Inn is a quiet and economical choice just 2 miles away from downtown area. Number one reason for picking this hotel is the pet-friendly policy, $35 one-time fee for small pets. The nightly rate of $100 didn't hurt either.
The room we stayed in is on the first level, you can tell it was used a lot because there are visible scratches on the wall, furniture, and carpet. The hotel itself is dated but the decor is new. The bathroom is SMALL but clean. Not much thrill otherwise. We spent most of time in downtown and didn't use hotel's other amenities like the pool/hot tub, bar, or restaurant.
The hotel staff was friendly and helpful when we checked in. Other guests at the hotel pretty much kept to themselves. Since we stayed on the first floor, we heard other pets throughout the weekend.
I would recommend the hotel if you're looking for a cheap place to SLEEP for a short period of time.
- Official Description (provided by the hotel):
- At our Carmel Ca. hotel you will find a quaint, yet stylish setting with an array of gracious amenities that include a heated pool, fitness center and the "Fuse" restaurant. We've truly created a destination within a destination. Additionally, we offer fantastic facilities for weddings, business meetings, retreats and special events. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Travelocity, Orbitz, Hotels.com, TripOnline SA, Hotwire, HotelsforEveryone, Cancelon, HotelQuickly and getaroom.com so you can book your Carmel Mission Inn reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Carmel Mission Hotel Carmel


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West Oz 1/4 Scale Speedway Association's venue TAMS GROUP SPEEDWAY in Henderson has been the home of the sport in WA since 2006. Located in Gemma Rd, off Cockburn Road. The track is part of the WARMS RC Model Park near the Go Kart circuit. (See map on right)
The Association is a not for profit organisation which aims to promote the sport of 1/4 scale speedway racing in a fun, family atmosphere. Dedicated to friendship in competition, 1/4 scale speedway is a growing sport for all ages with males and females enjoying the thrills, spills and skills of this challenging hobby. Membership to the Association in $80 per annum with a $10 nomination fee to WARMS. A nomination fee per race vehicle is charged per event.
Spectator entry is free, parking close to the track is available. Our canteen serves quality, tasty snacks at good old-fashion prices and fans can walk through the pits and get up-close to the drivers and the cars. Most events commence in the late afternoon and race through to approximately 10pm. The new season calendar is available on this webpage in August 2018.
These events are fun for all the family.
Last season we celebrated 10 years since racing commenced at this world class venue.
Our new season commences in September 2017 and continues through to April 2018.
Why not come along to one of our meetings and sample the West Oz Experience for yourself.
Contact us:
Postal address: 3/23 Junction Blvd, Suite 234, Cockburn Central WA 6164
Email: firstname.lastname@example.com
Fax: 08 9471 7758
Facebook: https://www.facebook.com/westozquarterscale/home
TAMS GROUP has the naming-rights sponsorship of the Henderson Speedway. TAMS GROUP have been valued sponsors of the West Oz 1/4 Scale Speedway Association Inc. for many years and play an important part in the operations at the venue.
The West Oz committee and members wish to sincerely thank TAMS GROUP for their support.


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Kittlaus was speaking at TechCrunch Disrupt event in New York City yesterday where he introduced Viv to the public and let her show off her skills. During a live demonstration, Kittlaus asked Viv a number of specific questions which she answered with élan. One of those questions put up by Kittlaus was "Will it be warmer than 70-degrees near the Golden gate bridge after 5pm the day after tomorrow?"
Soon you will be able to tell Siri your best kept secrets
As per Kittlaus, Viv will use its integration with a range of third party services to answer questions and to help users with information on the weather, hotel bookings, buying tickets as well as shopping online. He went on to say that 'perfecting the third-party ecosystem' will be the key to Viv's success as a virtual assistant.
You must be wondering which devices would feature Viv as their default digital assistant. To a similar question, Kittlaus said that while rumours about Google and Facebook trying to acquire Viv has been doing the rounds, they have not taken any big strides or made any offers to acquire Viv in the near future. However, Kittlaus did not mention Apple which means the Cupertino giant is probably content with Siri as the default virtual assistant in iPhones and iPads.
Siri can now beatbox and teach you a skill or two!
Back in February, 9to5Mac reported that Apple will introduce Siri to Mac devices later this year. Having made its appearance in Apple Watch and Apple TV last year, Siri's entry in the world of Macs will complete its presence across the entire Apple ecosystem. In Macs, Siri will neither appear as a swipe menu nor as a full screen view like in iPhones and iPads, but will appear as an icon in the top right corner of the Mac's menu bar. Last year, to improve Siri's communication skills, Apple bought VocalIQ, a British 'speech tech AI specialist' for an amount ranging between £33 million to £66 million.
VocalIQ aims to let you share natural conversations with speech assistants by developing routines and not limit conversations to mere commands. This way, the virtual assistant will learn from one conversation and will apply the learning to future conversations, getting better and better every day.


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Yes, I know he was a gangster and cold-blooded man, however, Fisk never struck as a particularly evil individual compared to Osborn, Doc Ock, Carnage, Venom, Shocker, Lizard, etc, etc and probably had a lesser body count than them. He also didn't orchestrate atrocities. Fisk was more on the lines of a corporate figure who cared less to kill innocent civilians and cause mayhem like the maniacs on Spider-Man's rogue list.
In all Fisk through society's cruelty was forced to live of crime and is one of the least 'evil' villains in comic history.


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Case Conclusion Date: 10.01.2011
Practice Area: Criminal defense
Outcome: Charges Dropped
Description: My client was from out of state and charged with posession of MDMA while traveling through California. I filed a motion to suppress the drug evidence due to an unconstitutional search of his person and won. Charges were dropped and my client never had to return to CA to deal with any of it.


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Color Wheel Socks by Stefanina
Welcome! You are browsing as a guestWould you like to see 13 projects made from this pattern and much more? create a free account What am I missing?
© stefanina
by stefanina Flickr
© stefanina
Color Wheel Socks
This pattern is available as a free Ravelry download
To fit a S - M - L Size
Foot circumference 20 - 21- 22.5 cm / 8 - 8.5- 9 inch unstretched
Leg length 16.5 cm / 6.5 inch
These socks have been designed to use sock yarn left-over.
Yarn :
MC about 210 m (1 skein)
CC about 100-120 m (each band of color uses about 3-4m)
Pattern are charted and special technique like Latvian twisted edge cast-on are explained with step by step tutorial.


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A simple method to make a switchable liquid crystal (LC) Fresnel lens with high diffraction efficiency and a low driving voltage was proposed based on the photo-induced surface modification of the vertical alignment layer. UV illumination alters the pretilt angle of alignment layers, a Fresnel zone-distribution hybrid alignment in the homeotropic LC cell can be straightforwardly achieved through UV exposure, yielding a concentric structure of the Fresnel phase LC lens. A remarkable diffraction efficiency of ~31.4%, close to the measured diffraction efficiency of the used Fresnel-zone-plate mask of 32%, was detected using a linearly polarized incident beam.
© 2010 OSAFull Article | PDF Article
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Let's say a large group of enemies, along with a few killer bots, are guarding a door I need to get through. Not having enough ammo to take them all on at once, I sneak in behind them and take control of all but one of their robots and simply disable them. (The fact that the guards don't notice their warbot is now a sparking, hissing pile of metal beside them is an admittedly weak point in the design.) With only one bot left, I take control of that, shoot the guard beside him and have the bot run like hell to the nearest rival guardpost. Here two of my enemies kill each other for me while I cheerily walk through the gate.
You can tell the developers are proud of their physics system because they put a basketball in your apartment right at the start of the game. There's no goal (that comes later), but it's a nice way to get your hands on the physics of the game world right away. The basketball seems to be covered in double-sided tape, of course, and it stops rolling far too soon, and you can sometimes turn a whole house into shambles just by walking through a room and knocking the furniture against the walls -- but otherwise, the physics are pretty solid and can be used in some interesting ways. I once crouched behind a barrel to try to get past a turret mounted in the ceiling. Once the turret saw me, it started firing and the barrel went spinning up in the air, leaving me totally exposed. Not only is that good physics, that's good gameplay.
With this in mind, it seems overly fussy to complain that the game makes too many cuts in terms of less important details. Where the first Deus Ex had an elaborate skill system, it's been absorbed by the BioMod and weapon modification features. You can still play a character who focuses on sniping or computer hacking if you want but you'll need to express that more through actions than by choices on a character sheet. Some die-hard RPGers have a bit of a problem with that but it has less impact on the gameplay and merely adds one more boundary between the player and the game. Ditto for the single type of ammo now used by all the weapons in the game. This at least, has a vaguely plausible scientific basis but I still don't get how I'm using the same bullets in my flamethrower as I use in my dart gun.
What's not overly fussy is complaining that you can walk into a coffee shop with a shotgun in your hands and no one seems to care. I seem to remember that this kind of thing is generally frowned upon so it would be nice if the characters in the game world had a similar response. But they're not terribly bright to begin with. Some enemies won't notice their buddies getting gunned down unless they actually hear it. Others won't care if you come in to their office and start snatching money right out of their lockers. Like Kelsey Grammar, you can put pretty words in their mouths but that doesn't make them smart.
The team has done a great job adapting the controls of the first game for the Xbox. The standard movement and look options are preserved and the D-pad offers nearly instant access to the six items currently stored in your toolbelt (weapons, medikits, etc.) or your biomods. That the game automatically equips your multitools if you try to perform an action on a lock is even better. That means you've freed up another belt slot for an item you might need in the thick of combat. Even so, you can pause the game on either the inventory or biomod screen to grab just the thing you're looking for. I will admit it seems kind of gamey that you can simply pause the game, down three health packs and kick on your regeneration biomod in the middle of a firefight.
There are a few things that you'll need to get used to. If you're used to using the right stick button to zoom in, you'll have to get used to using the left trigger now. This serves as the alternate fire button for all guns so it won't always zoom. It also took me a while to get used to "mantling" which is a fancy word for climbing. While you'll go up and down regular ladders just using movement controls (and quite stiffly, I might add), you have to use the jump function to climb up on crates and such. There's a bit of a problem with forward jumps knocking you backwards when you hit an object so it can be kind of a pain to get the timing right. After a few minutes of teary-eyed perseverance, I seemed to get the hang of it.Continues


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Platinum Vintage Diamond Ring
Part of the Harold Stevens vintage collection, this exceptional Art Deco Platinum ring contains the classic navette shape set with a beautiful collection of old European cut diamonds, sapphires and old Mine cuts! The diamonds are bright, and just light-up with sparkle. The filigree work, hand-engraving, on this ring is nothing short of spectacular, and is in near mint condition. Best worn as an engagement ring or the perfect right-hand ring, it's all about your style preference. The ring is contains 1.40 carats in total weight, and features a 0.50 ct. old European cut diamond in the center.
In-stock size 5
Need a finger size not listed? Please contact the store for sizing assistance.
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