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Will Smith can't keep up with 20-year-old Suicide Squad co-stars
Will Smith struggled to keep up with his younger co-stars on the set of 'Suicide Squad'.
The 47-year-old actor - who plays antihero Deadshot in the DC Comics blockbuster - has admitted he required plenty of shuteye after partying with his castmates including Cara Delevingne, 23, and Margot Robbie, 26.
Speaking at the European premiere of the movie at London's Odeon Leicester Square on Wednesday night (03.08.16), he said: "I'm 47. Do not hang out with 20-year-olds. Do not do it.
"It ruins every aspect of your 40-year-old life when you try to hang out with 20-year-olds.
"I had about six weeks on set when I was like: 'I can be 20, this is fun'. But from tattooing, to working 14-hour days and then hanging out for four hours, and parties on set... I need a nap."
'Suicide Squad' sees him reunite with his 'Focus' co-star Margot and he recently recalled being unimpressed by the blonde beauty when they first met - while she was annoyed by his tardiness.
Interviewing one another for E! News, Margot said: "When I first met you it was for the audition for 'Focus' and you were late. I'd come from Croatia and I remember being like 'Why is he late? I should be late.' "
Will retorted: "At least I was dressed for the interview. She walked into the audition and she had shoes like she'd walked through mud, shorts on, her hair wasn't done, I was like 'She doesn't want this at all.' "
But Margot insisted she had a good explanation for her unkempt appearance.
She said: "I'd lost my luggage. I'd been backpacking."
Margot also criticised Will - who has son Trey, 23, from a previous marriage, and Jaden 18, and Willow, 15, with wife Jada Pinkett Smith - for his lack of manners.
She said: "I hate it when you say 'huh?' It's rude.... Maybe I shouldn't be scolding a man that's twice my age."
Will added: "Somewhere as a child, Margot wasn't allowed to say 'Huh?', she had to say 'Pardon?'. It's a habit. She [shouts] 'It's pardon!'"


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Hybrid Commercial Truck Sales To Surge by 2017By Danny King September 8, 2011
Annual global sales of commercial electric-drive trucks will jump more than tenfold over the next six years as more companies invest in advanced powertrains to address what's likely to be a jump in diesel-fuel prices, Pike Research reported this week. Almost 101,000 medium- and heavy-duty hybrid trucks will be sold worldwide in 2017, up from less than 10,000 this year, according to Pike. North America will account for about a quarter of the hybrid commercial truck sales in 2017, while Asia Pacific will make up more than 40 percent, according to the green-technology research firm.
More businesses are investing in hybrid technology for their trucks as the global economy slowly recovers and diesel fuel prices continue to rise. Industry analysts have predicted rapid growth for electric-drive trucks because of the potentially substantial fuel-cost savings relative to conventional diesel trucks, which usually get well below 10 miles per gallon. Additionally, while many U.S. tax breaks for hybrid cars expired last year, analysts say the federal government is likely to continue to give tax breaks to companies that buy electric-drive trucks in order to help U.S. businesses cut both greenhouse-gas emissions and dependency on foreign oil. Since 2000, UPS has added more than 370 hybrid vehicles to its fleet, including 129 this year. FedEx has about 330 hybrid vehicles in its fleet.
Pike Research predicted last December that annual hybrid truck sales would eclipse the 100,000 mark in 2015 -- two years earlier than this week's forecast -- although the earlier study included hybrid buses. Daimler AG's Freightliner division and Eaton are among companies that have expanded hybrid powertrain production. Such powertrains can boost fuel economy relative to conventional diesel trucks by as much as 50 percent. Pike Research Senior Analyst Dave Hurst told AutoObserver that, while the numbers aren't surprising, the fact that lithium-ion batteries are the dominant type of batteries used in hybrid trucks is unexpected, because those batteries are more expensive than nickel metal hydride batteries. "Most hybrid truck manufacturers and system integrators such as Eaton have been using the more expensive lithium ion for years to capitalize on its better energy density," said Hurst. "In the U.S., use of nickel hydride for hybrid trucks is expected to peak in 2015 and then start to slowly decline."

subset: commoncrawl


text:
Has anyone rehomed a failed guide dog pup? Very interested...(19 Posts)
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Bruce Boudreau Fired
November 28, 2011 by staff
Bruce Boudreau Fired, The Washington Capitals on Monday fired coach Bruce Boudreau, who won 200 games faster than any coach in modern NHL history but stumbled regularly in the playoffs despite a talent-laden lineup featuring two-time league MVP Alex Ovechkin.
Boudreau was replaced by former Capitals captain Dale Hunter, who was scheduled to lead Monday's practice and make his debut behind the bench Tuesday night when Washington hosts the St. Louis Blues to begin a three-game homestand.
Hired four years ago on Thanksgiving Day, Boudreau went 201-88-40 in the regular season with the Capitals but just 17-20 in the playoffs. This season he tried a new approach, emphasizing accountability and the willingness to bench his star players — team captain Ovechkin included — as punishment for subpar performances.
Please feel free to send if you have any questions regarding this post , you can contact on
Disclaimer: The views expressed on this site are that of the authors and not necessarily that of U.S.S.POST.


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Frequently Asked Questions About Celiac Disease 09/30/2015This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc. Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.
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Psyche replied to Vinturi's topic in Gluten-Free Foods, Products, Shopping & MedicationsPre dx, Mike's made me sick. I figured it was the malt and stayed away from it. I am not going to try it now, post dx.
Psyche replied to SeekingSarah's topic in Celiac Disease - Pre-Diagnosis, Testing & SymptomsA lot of post-ops vanish from the online communities once they have lost the majority of the weight. I know one other who had the DS in 2009 (we had the same surgeon) and she was diagnosed post-op though very likely had it before as she had a child with Celiac. I agree with you. One big problem is that some of the diets often required pre-op will cause false negatives. Low-carb is a bugger for that. So will the protein shake diets.
Psyche replied to Brrrandy's topic in Celiac Disease - Coping WithI do notice different types of reactions. The more sugar (glucose, fructose, sucrose, etcetera) with it the quicker I react. Also in liquid form I have a faster absorbtion time. I get rashes if it is in anything I put on my skin - the itchies hit really fast with that. In the past, I have kept journals with what I consumed/used and my reactions. That helped to isolate reactions and track patterns.
Psyche replied to argybargy's topic in Celiac Disease - Coping WithKind bars, nuts, and non-gluten jerky were my best friends during a recent trip.
Psyche replied to powerofpositivethinking's topic in Celiac Disease - Coping WithNuts do that to me as well. My doctor told me it was normal, really, and to not stress about it. He did say that I likely did not have to worry about adding extra fiber if I was eating nuts.
Psyche replied to EmiPark210's topic in Gluten-Free Ingredients & Food Labeling IssuesNo. I lean towards eating organic and non-GMO as much as possible and prefer to buy straight from the farmer or pick it from my garden. I do appreciate that there are processed options out there but I am a fairly distrusting.
Psyche replied to Aprilelayne's topic in Celiac Disease - Pre-Diagnosis, Testing & SymptomsSoy is obnoxiously everywhere. I have not trusted fast food meat for years when I heard they started adding it to their 'beef'. My mother is incredibly allergic to soy (and a host of other things) so I have always been very cautious about soy. I can definitely see how snacks would be a problem. K is so overwhelmed by labels. We ended up putting some apps on our phones to help him figure things out.
Psyche replied to josh052980's topic in Celiac Disease - Coping WithI have far more issues if I do not take probiotics. I take supplements plus eat Greek yogurt daily.
Psyche replied to Alex J's topic in Gluten-Free Foods, Products, Shopping & MedicationsI have not been able to find them. I will have to hit our Publix and check.
Psyche replied to mushroom's topic in Gluten-Free Ingredients & Food Labeling IssuesNow I love Whole Paycheck even more!
Psyche replied to kareng's topic in Gluten-Free Foods, Products, Shopping & MedicationsI wiil have to go to Whole Paycheck Foods and see if I can find those. Thanks! There are definitely days where something quick and nukable would come in handy. My picky husband might even eat that.
Psyche replied to Adalaide's topic in Gluten-Free Foods, Products, Shopping & MedicationsBubble gum? I will have to try these!
Psyche replied to Adalaide's topic in Gluten-Free Foods, Products, Shopping & MedicationsOh! I will have to send my husband to Costco today.
Psyche replied to norman516's topic in Celiac Disease - Post Diagnosis, Recovery/Treatment(s)The bloating and intestinal pain were the first to subside. That was a huge relief - almost like instant gratification.
Psyche replied to bekkaz's topic in Celiac Disease - Pre-Diagnosis, Testing & SymptomsFor me, it depends on what it is, honestly. Some things I can tell within 15 minutes because I start blowing up and others I will get slammed with the next day.


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Author | exchange4media News Service | Monday, Jun 10,2002 7:24 AM
Playwin Infravest Pvt Ltd., plans to appoint 6,500 more retailers in the current fiscal to sell Playwin Sikkim Super Lotto Jackpot tickets.
At present the company has 3,500 retailers all over the country, through whom 7.5 crore tickets have been sold so far and Rs 37 crore have been given away as prize money to the winners.
Though the Playwin Super Lotto online lottery was launched in the country only three months back, it has already generated revenues of Rs 74 crore during this short period. Lately, it has been clocking weekly revenue of over Rs 8 crore.
According to company source, even Maharashtra and Karnataka governments are planning to launch their own versions of online lottery.
According to company anyone who has a shop, business establishment or commercial space in a reasonably good location and is willing to deposit Rs 3.5 lakh is eligible to become a Playwin retailer. The retailer would be paid 8.5 per cent interest annually on this deposit and it would be refunded if any dealer chooses to withdraw.
Against this deposit, the company provide the retailer a terminal and equipment worth Rs 5 lakh. While every retailer is expected to give a minimum sales of Rs 4 lakh worth of tickets a month or Rs 1 lakh every week, he gets 5 per cent commission on the total sales. Besides, he is also entitled to 1 per cent of the prize money, provided the winning ticket is sold from his store.


text:
The 38-year-old, who was playing the lead in Song of the Earth at Covent Garden's Royal Opera House, decided to retire while at the peak of her powers.
She has been with the Royal Ballet for 20 years, and became its youngest chief performer at the age of 20.
Bussell, who was made a CBE last year, is planning a show with Welsh soprano Katherine Jenkins called Viva La Diva.
She explained to the BBC why she wanted to end her career on a high.
"If I finish now I'll be able to look back and be really happy," she said.
"If I keep going for another five years I might not have the same feeling about it."
'Brilliant farewell'
National newspapers have given glowing reviews of Bussell's role, with the Guardian's Judith Mackrell calling it a "poignant and brilliant farewell".
She added that the ballerina's role in Kenneth MacMillan's production, which Bussell first performed in 1990, was "danced flawlessly".
Sarah Crompton, writing in the Daily Telegraph, said the performance evoked "translucent images of a ballerina who has burnished the stage for 20 years".
She also praised Bussell's "ability to make everything look beautiful and good".
The dancer announced her intention to step down from her role at the Royal Ballet in 2005, saying she wanted to spend more time with her family.
At the time, she said she was "devoted to the company and always will be".
Most Popular Now | 56,514 people are reading stories on the site right now.";


text:
|21 Jun 2012
Windows 7 Ultimate x64, Windows 8 RP x86, Linux Mint 12 x64
kodak printer will not connect over wifi!
I have a Kodak Hero 3.1 connected to my Motorola Surfboard SBG8560 modem/wireless router. It connects fine and I can find the printer and even print hen my computer is connected to Ethernet but not when I switch over to wifi. This is on a computer running windows 8 rp but I know the os is not to blame because it is not found by my roommates mac on wifi or my other roommates windows xp machine. i figure it must be a router setting that i am missing. When i run arp -a in cmd this is what i get:
C:\Users\William>arp -a Interface: 192.168.0.7 --- 0xc Internet Address Physical Address Type 192.168.0.1 20-e5-64-e2-4b-bb dynamic 192.168.0.6 f4-6d-04-40-d6-0e dynamic 192.168.0.10 e0-69-95-97-e9-7a dynamic 192.168.0.255 ff-ff-ff-ff-ff-ff static 18.104.22.168 01-00-5e-00-00-02 static 188.8.131.52 01-00-5e-00-00-16 static 22.214.171.124 01-00-5e-00-00-fb static 126.96.36.199 01-00-5e-00-00-fc static 184.108.40.206 01-00-5e-7f-ff-fa static 255.255.255.255 ff-ff-ff-ff-ff-ff static Interface: 192.168.0.10 --- 0xd Internet Address Physical Address Type 192.168.0.1 20-e5-64-e2-4b-bb dynamic 192.168.0.4 e0-ca-94-1d-ce-f1 dynamic 192.168.0.6 f4-6d-04-40-d6-0e dynamic 192.168.0.255 ff-ff-ff-ff-ff-ff static 22.214.171.124 01-00-5e-00-00-02 static 188.8.131.52 01-00-5e-00-00-16 static 220.127.116.11 01-00-5e-00-00-fb static 184.108.40.206 01-00-5e-00-00-fc static 18.104.22.168 01-00-5e-7f-ff-fa static 255.255.255.255 ff-ff-ff-ff-ff-ff static C:\Users\William>
.7 is my wireless card
and .4 is the printer
i noticed that i cannot find all of the devices on my network when connected to wireless including the router.
Please Help!
|My System Specs
|23 Jun 2012
Win7 & Win8 64bit
Welcome to Seven Forums,
Did you setup the network security with the correct pass-phrase on the printer?
Try running AdvancedIPScanner, you'll be able to see all your network devices.
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I have an older model Kodak Camera. (C182 Kodak 12mp with Kodak EasyShare Software.) Kodak was completely USELESS; they won't help me unless I buy a new camera. When I connect the camera to the computer it doesn't show up like it used to. Usually I can connect it to the computer and turn the...
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Hi i have a kodak esp.c310 and i get this problem when ever 1 ink cartridge is out i cant print anything even if the black and white one is full and i want to print in just black and white it wont let me is there anyway to get past this?
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I can't get my new laptop to recognize my old Kodak 500 Photo Printer as a printer. It shows up as a "device" instead, and so I can't print to it. Has anyone else had this problem and found a fix?
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Anyone know where i can get a driver for this printer?
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I have a laptop running Windows 7 (64 bit) and I cannot get my Kodak 5100 AiO printer to work. I have downloaded the latest software from the kodak website and downloaded the latest firmware but programs such as notepad, paint or word will not print. The only thing I can get to print is a...
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A variety of research is underway at TRI, but in the past 3 years many projects have achieved results which qualify them as 'translational' research. The most successful projects at TRI collaborate across partners and disciplines, creating themes which we are collecting into flagship programs.
TRI currently hosts 4 flagship programs, each with a collection of related translational projects. By grouping these projects together we can identify where resources are needed or duplicated, and encourage collaboration between science and health. Conversations inspired by these programs have led to new projects identified such as Prof Carolyn Mountford's clinical imaging techniques to test Prof Ian Frazer's cancer immunotherapy treatment in clinical trials.
It could be said that TRI was built on immunotherapy, with many of the main translational projects in this program being underway since our official opening 3 years ago. The cervical cancer and rheumatoid arthritis vaccine projects are world class examples of the success of immunotherapy.
> Read more about the Immunology program at TRI
New to TRI with the appointment of CEO Professor Carolyn Mountford in 2014, a collection of imaging projects use diagnostic techniques to understand the gut/brain axis, high risk BRCA breast cancer changes, brain changes from PTSD and trauma from blast injury or full contact sports.
> Read more about the Clinical Imaging program at TRI
Recently we have identified a strong theme of work in the area of Microbiome research and are in the process of gathering information about these projects to inform a possible program.
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Nyquist is an elegant and powerful language for sound synthesis and music composition. Unlike score languages that tend to deal only with events, or signal processing languages that tend to deal only with signals and synthesis, it handles both in a single integrated system. It is also flexible and easy to use because it is based on an interactive Lisp interpreter. You can design instruments by combining functions (much as you would using the orchestra languages of Music V, cmusic, or Csound). You can call upon these instruments and generate a sound just by typing a simple expression. You can combine simple expressions into complex ones to create a whole composition. It runs under any Unix environment, MacOS, Windows 95, and Windows NT, and it produces sound files as output (or direct audio output under Windows).
OCRFeeder is a document layout analysis and optical character recognition application. It is able to automatically outline a document image's contents, distinguish between graphics and text and perform OCR over the latter. It can export to several formats, its main one being ODT. OCRFeeder has a GTK+ graphical user interface that allows the user to control the application and, for example, edit and correct the automatic recognition. It can also be used from the command line for automation.
Open Sound World (OSW) is a scalable, extensible programming environment that allows musicians, sound designers, and researchers to process sound in response to expressive real-time control. It combines a familiar visual patching paradigm with solid programming language features such as a strong type system and hierarchical name spaces. OSW also includes an intuitive model for specifying new components using a graphical interface and high-level C++ expressions, making it easy to develop and share new music and signal processing algorithms.
PanBI is a collection of analytics modules for existing information systems. For each information system, it provides data extraction, transformation, and loading logic coupled with an OLAP schema, delivering OLAP functionality to an unprecedented user base. It extracts data from the source database, sets up a warehouse schema, loads the data into the warehouse, and has defined OLAP cubes. It does all this automatically for a one-click-run experience. Supported systems: dotProject, NesterSoft WorkTime, Subversion, and MantisBT (under development).
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Pause determines the location of silences in an audio file for use in fragmentation of large recordings, studies of pause duration, and the like. It generates both a nicely formatted table intended to be read by people and a simple tab-delimited file that is easily parsed by software.
Data synchronization, replication, and transformation software.
A SCXML to C++ compiler.


text:
Micho says Uganda game 'won't be easy' for Egypt
Uganda manager Milutin 'Micho' Sredojević said that Egypt's clash with the Cranes...
Newly appointed Nigeria manager Samson Siasia has announced a 42-man squad in preparations for the 2017 AFCON Group G qualifier against Egypt.
The squad includes 20 abroad players and 22 Nigeria-Based players with John Obi Mikel, Victor Moses, and Odion Ighalo amongst the the called-up players. Lazio midfielder Ogenyi Onazi will be unavailable for the first encounter in Nigeria due to red card, but can take part in the game in Alexandria.
Siasia failed to convince retirees Vincent Enyeama and Emmanuel Emenike to return to the Super Eagles as they are not part of the announced squad.
The Nigeria national team camp is set to kick-off on March 6th. Players traveling from overseas will join the group on March 20, five days before hosting the Pharaohs.
Goalkeepers: Ikechukwu Ezenwa, Olufemi Thomas, Emmanuel Daniel, Carl Ikeme (Wolverhampton Wanderers, England), Daniel Akpeyi (Chippa United, South Africa).
Defenders: Efe Ambrose (Celtic FC, Scotland), Abdullahi Shehu (Uniao da Madeira, Portugal), Elderson Echiejile (AS Monaco, France), Stanley Amuzie (Olhanense FC, Portugal), Godfrey Oboabona (Caykur Rizespor, Turkey), Kenneth Omeruo (Kasimpasa FC, Turkey), Kalu Orji Okogbue, Chibuzor Okonkwo, Mathew Etim, Austin Oboroakpo, Sincere Seth, Segun Oduduwa, Chima Akas, Chris Madaki, Oke Ogogatewho.
MIdfielders: Ifeanyi Mathew, Usman Mohammed, Etebo Oghenekaro, Yau Hassan, Stanley Dimgba, Ogenyi Onazi (SS Lazio, Italy), John Mikel Obi (Chelsea FC, England), Kelechi Iheanacho (Manchester City, England), Azubuike Okechukwu (Yeni Matalyspor, Turkey).
Forwards: Ahmed Musa (CSKA Moscow, Russia), Moses Simon (KAA Gent, Belgium), Victor Moses (West Ham United, England), Aminu Umar (Osmanlispor FK, Turkey), Odion Ighalo (Watford FC, England), Aaron Samuel (CSKA Moscow, Russia), Alex Iwobi (Arsenal FC, England), Fanendo Adi (Portland Timbers, USA), Ezekiel Bassey, Prince Aggrey, Bright Onyedikachi, Chisom Chikatara, Godwin Obaje.


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Scarlett Johansson as The Director
Scarlett Johansson is spotted on the set of her directorial debut New York, I Love You starring Kevin Bacon. Look at the smug look of contentment on her face as she looks into a screen that lets assume is blank. Also, note the beret perched carefully on her head. All signs of a good director… More »


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Willis may refer to:
- Lord Willis Kemeny, 9th Earl of Howell, a Manticoran Peer of the Realm.
- Willis Jennings, an officer of the Solarian League Navy.
- Alfred Willis, tactical officer of GLAC Intrepid.
- the Willis, a starship in Andrew Warnecke's private navy.
- the Willis System, one of the systems in the Chalice Cluster.
|This is a disambiguation page — a navigational aid which lists pages that might otherwise share the same title. If an article link referred you here, you might want to go back and fix it to point directly to the intended page.


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Women's Soccer Comes from Behind for 2-1 OT Win
Oct. 7, 2011
Box Score (PDF) | Box Score | Photo Gallery
LEXINGTON, Ky. - A strong second half with more aggressive play led the UK women's soccer team to a 2-1 come-from-behind win in overtime Friday at against the Arkansas Razorbacks.
Kentucky (10-3-0, 3-2-0 Southeastern Conference) totaled 24 shots in the match including 12 in the second half and one in overtime which proved to be the golden goal.
Only a minute and a half into the first overtime, Kentucky controlled the ball, sending it inside the 18-yard box where Caitlin Landis was dragged down by an Arkansas defender resulting in a penalty kick. Senior captain Kelsey Hunyadi stepped up and converted the kick for her eighth goal of the season and the win. It was her third game-winning goal of the season.
"Kelsey has scored to the right, to the left and down the middle this year," UK head coach Jon Lipsitz said. "People will try to scout her, but she is very sophisticated in that way. People don't realize how Kelsey works on these little details and they might not remember that she missed one to end our season last season and that sat with her."
"It's a huge win; I was excited," Hunyadi said. "I like those moments. I like being able to put the game away; I felt like I needed to. I missed a lot of opportunities tonight, and it was my way of making it up to them tonight."
In order to get the match to overtime, the Wildcats needed a strong, aggressive second half which they got when they moved freshman Arin Gilliland up top.
"We weren't happy with our play in the first half," Lipsitz said. "We have certain expectations for our play, and we didn't meet those in the first half. We talked about becoming more aggressive and having more of a sense of urgency. When you want to be more urgent, you insert Arin Gilliland up top. She certainly responded in a great way."
Trailing 1-0 in the 50th minute, the Wildcats got exactly what they were looking for, an opportunity for Gilliland. Natalie Horner got the play started, putting the ball over the top of the Arkansas defense to Caitlin Landis. Landis took the pass and centered a shot to a charging Gilliland in front of the goal. The freshman beat the Arkansas keeper for the equalizer and her third goal of the year.
Arkansas (4-8-0, 2-3-0) got on the board in the 35th minute when Kailey Anderson grabbed a rebound off a shot from Lauren Locklear and rifled it past UK goalie Kayla Price.
The win pushed Kentucky's win total to 10 for the 12th time in program history. It marks the first time UK has tallied back-to-back 10-win seasons since the 2006 and 2007 seasons.
UK remains undefeated at home and is now 17-6-4 on its home turf under Lipsitz, who registered his first win over the Razorbacks.
The weekend action continues on Sunday when Kentucky hosts LSU, ranked 18th in the latest RPI, in a 1:00 p.m. ET start. UK women's soccer and the UK HealthCare Pediatric Unit are teaming up for the match dubbed, "Kick Cancer."
Admission to the match is $5 with $1 dollar from every ticket sold being donated to the UK Healthcare Pediatric Unit. Official KICK CANCER match t-shirts will be sold online on the UK team shop at UKAthletics.com.
The Wildcats will be wearing pink jerseys, and immediately following the match, the jerseys will be auctioned off on the UK Team Shop website at UKathletics.com. The auction will go from Sunday, Oct. 9th at 1:00 p.m. to Friday, Oct. 14th at 5:00 p.m. ET.
The Wildcats will also being wearing gold shoes laces in honor of pediatrics. Those same shoe laces will be sold at the game with all profits going to the pediatric unit.
Also following the match there will be an on-field post game ceremony to honor all those that have been affected by cancer.


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Made with a dash of love and these yummy ingredients, 1/4 of a mango, per pouch.
Organic Mango Puree, <0.5% Of: Organic Lemon Juice Concentrate.
To Serve: Squeeze onto a spoon or serve straight from the pouch! If you prefer, warm pouch in a bowl of hot water. To Store:Store in a cool, dark place. Refrigerate after opening and serve within 24 hours. Do not microwave or boil pouch.
Always refer to the actual package for the most accurate information


text:
Hillary Clinton compared Republican presidential candidates who hold conservative views on abortion and women's reproductive rights to "terrorist groups" in a Cleveland speech on Thursday.
"Now, extreme views about women, we expect that from some of the terrorist groups, we expect that from people who don't want to live in the modern world, but it's a little hard to take from Republicans who want to be the president of the United States," Clinton said. "Yet they espouse out of date, out of touch policies. They are dead wrong for 21st century America. We are going forward, we are not going back."
RNC response to Hillary Clinton's outrageous rhetoric comparing political opponents to terrorists:
"For Hillary Clinton to equate her political opponents to terrorists is a new low for her flailing campaign. She should apologize immediately for her inflammatory rhetoric."
- RNC National Press Secretary, Allison Moore


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In honour of the 500 year anniversary of the visit of emperor Maximilian the city of Sankt Wendel organizes a grand authentic knightly tournament. The best jousters in the world, from three continents and seven countries, were invited to a competition at the highest sporting level of a quality that hasn't been seen for hundreds of years ... [read more]
The competitors are altogether extremely well trained riders and fighters, who are experts in this field. One of the riders, for instance, is also committed to this theme in his civil life. With a PhD for his internationally acclaimed work in arms and armour research ... [read more]
Based on the points achieved in the Jousts and in the Melées the winners of the day and on Sunday the overall winner will be determined ... [read more]
The time between the displays will be filled with live music and a show act of the "Spandieratori e musici Contrada Monticellii", who as multiple italian Champions perform the art of Flag waving with virtuosity ... [read more]


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I'm Hassan Benzine. I'm born and raised in the Morocco Montains and i work as a Tour Guide in Southern Marocco, that is the most visited part of Marocco because of it's interesting nature.
I enjoy my job as a Tour Guide and I would like to guide you through the beautiful land of Marocco being able to join you in you Greatest and most Wonderfull Holiday in Southern Marocco.Read about the attractions.
I can speak several languages: Berber, Arabic, French, English and i also know Brittish Sign Language (BSL) so i can guide deaf people. Communication will not be a problem. I have been doing tours for a couple of years now with people all over the world, among others England, France, USA and Sweden.
I have also been working in a youth hostel from the International Organization and I have a lot of experience.
For persons that are new to Marocco, a guide is a must! With me, you will neither get lost, nore lose any time and I will see that you experience the most beautiful parts of my home country. Read about how you can hire me!
There are so many things to see and experience in Marocco: the Beach Mountains, the Valleys and the Desert. I can guide you through all that and more! Plan a Tour with me!
Hassan Benzine
Travel Tourism Africa Marocco Tours Guide Itinerary Desert Trekking Camels Arabic Berbers Sahara Expedition Climbing Atlas Mountains Adventure Skiing Marrakesh Dunes


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This Tyrolit 223033 BASIC* 350mm dia cut-off wheel for steel provides high stock removal performance and boasts a long service life.
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This tool is ideal for use on large, portable and stationary machines.


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We've been starved of Test cricket for nearly four months now. Ever since Pakistan drew in Wellington, to win the series against New Zealand, there's been a glut of limited-over matches - the World Cup, Australia in Bangladesh, the IPL and Pakistan in the West Indies. Re-adjusting attention spans to the pace of five-day cricket might take a while, for both players and us. It is in Guyana, at the other end of the cricket universe from where they last played, that Pakistan resume the Test calendar, in pursuit of a success they've never achieved before.
Pakistan have never won a Test series in the West Indies. They've beaten them at home and at neutral venues (UAE in 2001-02), but in six trips to the Caribbean, Pakistan have lost four series and drawn two. The most memorable of those battles was in 1987-88, when Imran Khan's team held its own against the champion side Viv Richards inherited from Clive Lloyd in three monumental Tests. One-all it finished. The last two were thrillers. Unfortunately, Pakistan and West Indies have regressed since that watershed tour, and it would be fanciful to expect Misbah-ul-Haq and Darren Sammy's teams to produce entertainment of comparable quality.
Whether Pakistan or West Indies are in greater disorder could make for protracted debate. About ten months ago, it would have been Pakistan. Their captain (Shahid Afridi) jumped ship and retired from Tests, while his successor (Salman Butt) and their two best fast bowlers (Mohammad Asif and Mohammad Aamer) were embroiled in a spot-fixing scandal and then banned by the ICC. From the cold the selectors recalled Misbah and then made him captain. His chalice, however, hasn't been poisoned and Pakistan have been uncontroversial under his leadership. They also drew against South Africa and won in New Zealand. Pakistan, incredibly, appear well settled.
It is West Indies who appear to be in turmoil. Chris Gayle, Dwayne Bravo and Kieron Pollard turned down board contracts, preferring to remain unshackled to pursue lucrative assignments. And ever since West Indies were eliminated from the World Cup, by Pakistan, there's been a slanging match between the WICB on one side, and the WIPA and several players on the other, over how cricket is run in the region and how cricketers are treated by administrators. The upshot of the series of events is that West Indies will play the Test series against Pakistan without Gayle and Bravo, two players who would have walked into the starting XIs. Also missing is fast bowler Jerome Taylor, who's playing in the IPL.
West Indies have won only three series since Sri Lanka visited in 2003. Two of those were against Zimbabwe and Bangladesh. Their only success against a top side was the 1-0 result against England in 2009, a victory that was due to a searing spell from the now-absent Taylor.
Form guide
(most recent first)
West Indies: DDDLD
Pakistan: DWDDL
Watch out for...
Two local lads, Shivnarine Chanderpaul and Devendra Bishoo. Chanderpaul was dropped from the ODI series against Pakistan, exchanged lengthy letters with the WICB, and is now back for the Tests. He had made unflattering claims about how the team management kept telling him how to bat, even during his innings, and then subjected him to an interrogation afterwards. He's going to be playing in the same set up, so watch out for men with drinks running frequently to the middle while Chanderpaul is batting. His performances, however, will be critical in an inexperienced batting order.
While Chanderpaul has played 129 Tests, Bishoo is yet to play one, and will most certainly make his debut at Providence. He was a refreshing revelation during the World Cup and his legbreaks and googlies were the only thing that brought West Indies wickets (apart from a run-out) in the first two ODIs against Pakistan. He will be the solitary spinner in the XI, so is shouldering a large responsibility for someone so raw.
There have been questions over Darren Sammy's place in the limited-overs team - he's the third seam-bowling allrounder along with Bravo and Pollard - and whether he would win a spot by merit if he wasn't captain. Bravo is playing the IPL, so Sammy is the only allrounder in the Test squad, but he will be under pressure to show he belongs in a format that demands greater skills than the shorter versions do. At present, Sammy averages 16.72 with the bat and 31 with the ball, which isn't really good enough.
Azhar Ali is an extremely different batsman compared to Umar Akmal, who has been Pakistan's next big thing for a while now, but no less valuable in this series. While Akmal oozes aggression and indiscretion, Ali is patient. He's made six half-centuries in 19 innings and is searching for his maiden hundred. In the absence of Younis Khan, Ali's responsibility will be to provide stability in the middle order.


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Course: 5K on the Prep Campus. More than 90% of the course is grass; spikes are recommended.
Sanction: NFHS for USA.
Schedule : (subject to change)
12:30 p.m. Coaches' Meeting
1:00 p.m. Open 5k (For runners not entered in other races, Boys and Girls together)
1:30 p.m. Freshman Boys
2:00 p.m. Freshman Girls
2:30 p.m. Seeded Varsity Boys
3:00 p.m. Seeded Varsity Girls
3:30 p.m. Unseeded Varsity Boys
4:00 p.m. Unseeded Varsity Girls
4:30 p.m. Division I JV Boys (Pick One)
5:00 p.m. Division II JV Boys (Randomly Assigned)
5:30 p.m. JV Girls
Fees: $175 for single team (boys or girls) $250 for both boys and girls teams. Teams may enter a whole complement of races for this single fee.
Entry check payable to Woodward Relays and labeled Classic.
Deadline: Fri. Oct. 13, 2017 by 6pm
eMail inquiries to:
Greg Dunston - email@example.com
Read Coaches letter for complete entry info before entering.
Coaches Letter available here
Register through www.athletic.net


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There is an upsurge in the cases of cancer in the U.S and indeed worldwide.
With nearly 1.5 million people diagnosed with one form of cancer or the other, it has become pertinent that everyone is cautious of those carcinogenic foods that can cause the development of cancerous cells in the body.
Here are some foods you should be wary of;
1. Avoid Farmed Salmon
It is estimated that more than 60% of all salmon consumed in the U.S are farm raised.
It is believed that these fish are fed with feeds that are contaminated with pesticides, antibiotics and known carcinogenic chemicals.
These salmons live in a crowded environment and are likely to have more sea lice than those salmons raised in the wild.
These salmons are also fed with chemicals to give their flesh that reddish pink colour that should happen naturally.
Farmed salmons also have less solid omega-3 than their naturally raised relatives because of their eating regimen. It has also been discovered that farmed salmons have large amounts of mercury, PCB and cancer causing dioxins. Stay clear of canned salmon and if you have to buy it fresh then check the label to ensure that what you purchase is actually wild sockeye salmon.
2. Stay Clear Of Canned Tomatoes
The can of canned food is lined with a chemical known as bisphenol-A or BPA.
In a 2013 study by the National Academy of Sciences it was discovered that BPA has a great effect on the body similar to how genes act in the cerebrum of lab rats.
The high acidity in tomatoes make them very hazardous and when the BPA gets into the tomatoes as a result of this, it makes the tomatoes even more dangerous.
FDA laws do not mandate the stating of BPA on the labels but that does not mean it isn't there, so avoid canned tomatoes and go for fresh organic ones.
3. Stay Off Soda Pop
It is believed that people that consume a soda a day stand a higher chance of having a stroke than those that don't drink sodas.
This was a publication made by the American Journal of Nutrition.
You will quickly develop insulin resistance and spike up your glucose levels if you consume sodas daily because they are packed with sugar and cause weight gain.
They also cause gastro-esophageal reflux sickness, they contain artificial colorings that are also carcinogenic in nature.
4. Eat Less Processed Meat
It is widely acknowledged that the preservatives and salt used in processed meat is very harmful to the human body. This was stated in the journal of BMC Medicine by analysts.
In a study conducted that included individuals from 10 European nations, it was observed that 1 out of 17 subjects in the research died as a result of complications from the consumption of processed meat. It also stated that those people that consumed 160 grams or mire of processed meat where 44% more likely to die in 12 years' time compared to those people that only ate about 20 grams or less of processed meat.
Processed meat contains high amounts of sodium nitrates which are carcinogenic even though they may make the meat appear fresh and visibly appealing.
Smoking meat is also not good as the meat derives tar which is similar to that found in cigarettes.
5. Stop Eating Microwave Popcorn
Microwave popcorn packs are believed to be lined with a poisonous chemical known as perfluorooctanoic acid ( PFOA).
It is believed that overexposure to this chemical can lead to liver, kidney, testicular, bladder and pancreas cancers.
Most microwave popcorn use soybean oil (which is a GMO product) as well as other additives such as propyl gallate, which causes skin rashes and digestive problems.
6. Careful With Those Potato Chips
You will gain weight quickly if you consume potato chips as they are packed with calories and fat.
It is believed that consuming just an ounce of potato chips daily will lead to a two pound increase in weight in a year, this was published by the New England Journal of medicine.
Potato chips are also loaded with high amounts of sodium which can lead to hypertension in people.
Potato chips also have artificial colouring and chemical additives that are carcinogenic.
They are fried under very high temperatures in order for them to be firm but as a consequence they form a compound called acrylamide which is a carcinogenic compound that is also found in cigarettes.
7. Eating Highly Smoked, Pickled Or Salted Food Is Bad For You
Nitrate cured foods or foods with nitrites which act as preservatives as well as coloring to meat are bad for you.
These foods change to N-nitroso once in your body and this is known to cause cancer.
Nuts and meat that are smoked are packed full of tar which is similar to that in cigarettes and this is a cancer causing agent.
Your bacon, salami and sausages are high in sodium and fat that can lead to colorectal cancer as well as stomach malignancy which is common place in places like Japan known for its salted and smoked food.
8. Genetically Modified Food
These are foods that have been grown with chemicals and also modified by chemicals.
In a scientific experiment conducted by Dr. Pusztai at the Rowett Institute in Scotland, the lab rats were given GMO foods to eat and in just 10 days all the rats had pre-malignant cell developments, damaged immune systems and even smaller brains and livers.
9. Refined Sugar Is Bad For You
These will raise your insulin levels, they are also good for cancerous cells as they feed on it to growth in size.
In 1931 German Nobel laureate in medicine, Otto Warburg discovered that both tumors and cancers feed on sugars growing in size in the process.
It was found that cancer cells feed on fructose-rich sweeteners such as high-fructose corn syrup (HFCS).
This is because malignancy cells metabolized HFCS more effectively and quickly.
Your soft drinks, pies, cakes, cereals and juices are packed with refined sugar and HFCS indicating why tumors and cancer are on an increase these days.
10. Quit Eating Red Meat
It was discovered in a study spanning over 10 Years that eating red meat even in small quantities increased a man's risk of acquiring cancer by 22% while that of a woman increased by 20%.
Cancers such as prostate, colon and breast cancer is common place.
In another study on 150,000 subjects aged between 50 and 74 it was discovered that colon cancer was common when red meat was consumed regularly.
You should eat more of poultry and fish rather than red meat if you want to reduce your risk of getting colon cancer.
Source: www.healthyfoodstar.com


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Welcome to our Christmas Tree fundraiser page!
This fundraiser is for our LOCAL Raleigh/Apex area friends. There are pick up or delivery options in both locations (specify your location of choice).
Shop with secure confidence using Paypal, your credit card or DOWNLOAD and mail an order form with your check. Interlocking Ministries ministers in Kenya, Africa with mission trips, camp programs, school visits, orphan and widow assistance and always sharing the Word of God. Visit our WEBSITE to learn more about where your donation goes. Your support is appreciated. Thank you! ~Bobby & Page Johnson
Ordering deadline is November 16, 2016
The pickup dates are: Nov. 25-26
Questions? Contact us by clicking here.
Clicking on items gives you more info. Your shopping cart will be active until you leave the store.
We are only taking pre-orders. We aren't buying any extra trees. Don't forget to order "pre-drilled" if you have (or are ordering) a spike tree stand (which we highly recommend)
Thank you for visiting. Please share this fundraiser with a friend! http://shop.interlockingministries.org
|Sponsor a camper
You are encouraged to pick up your order 9am-6pm on Nov. 25 or Nov 26 at 10710 Six Forks Road, Raleigh, NC 27614. However, we offer delivery to the North Raleigh area and Apex area (if you add it to the cart for $20). In the "special instructions" on check out, you can enter the date you would like your tree delivered Nov. 25 or 26. Delivery includes placement of the bound tree to the outside of your home. Our delivery volunteer will attempt to place your tree in the shade if you aren't at home and shade is available.
Thank you for visiting. Please share the fundraiser with a friend!
Copy and paste this link to your facebook, twitter or email: http://www.shop.interlockingministries.org


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|Message view
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|« Date » · « Thread »
|Luc Maisonobe <Luc.Maison...@free.fr>
|Re: [Math - 403] Never propagate a "NullPointerException" resulting from bad usage of the API
|Sun, 06 Mar 2011 12:44:50 GMT
Le 05/03/2011 00:59, Gilles Sadowski a écrit : > Hello. Hi Gilles, > >> [...] >>> So, what is the lesson from having this case? Is the whole method a duplicate >>> that should be replace by a call to something in "linear"? Or is it a proof >>> that some exceptions might be appropriately used outside of "linear"? >> >> I think the method should be moved to a new >> TruncatedCholeskyDecomposition or RectangularCholeskyDecomposition. I >> don't think we can add it has a new implementation or it should be added >> to the existing CholeskyDecomposition because the decomposition matrix >> shape is not triangular. > > If you are going to create new classes in "linear" so that the current CM > code only throws "...MatrixException"s from inside that package, I'm not > going argue anymore about moving those exceptions to "linear". But, if this > situation arises again, then we will create a incompatibility by moving the > exception from "linear" to "exception"... That's why I think that it's safer > (from a stability point-of-view) to have them all in "exception". I don't think this will happen very often. So let's create the new classes (I'll open a Jira issue for that) and move the linear algebra related exceptions back to the linear package. > >>>>> [...] >>>> >>>> For example to have a single point where to put breakpoints for >>>> debugging. I used that a lot as such exceptions mainly occur during >>>> development phase. >>> >>> Thus, IIUC, this is a developer feature. >>> I understand the convenience, but I wouldn't trade code consistency for it. >>> I'd rather keep "NullArgumentException" (or a "MathNullPointerException" if >>> we want it to extend the standard NPE) so that you can put your breakpoint >>> in the constructor of that exception. Thus you have the convenience without >>> the code asymmetry. >> >> OK for MathNullPointerException. > > With a "checkNotNull" function, it should not be necessary. > But I didn't quite understood your reasoning concerning such a method and > whether it's OK to implement or not (cf. below). > >>> >>>>> >>>>> Not only is this inconvenient, it is also dangerous: I was bitten more than >>>>> once writing this: >>>>> --- >>>>> MathRuntimeException.createNullPointerException(); >>>>> --- >>>>> which the compiler happily accepted. >>>> >>>> Of course, as it would have accepted: >>>> >>>> new NullPointerException(); >>>> >>>> Unfortunately, we cannot put the throw inside the method. Trying to do >>>> this prevent the optimizer to wor properly as it does not know in the >>>> caller that the method would never return, and it brings lots of >>>> warnings from code checking tools for the same reason. >>> >>> The method alternative looses much of its appeal because it doesn't perform >>> the complete action ("throw" included), as I had initially assumed when >>> wrongly leaving out the "throw" statement. I wouldn't have written >>> new NullPointerException(); >>> as, to me, it would have _obviously_ looked wrong. >>> >>> I don't understand the problem with the "optimizer". There are several >>> methods in CM that seem to perform similarly (i.e. they check something and >>> throw an exception). An example is "checkOrder" in "MathUtils". >>> In fact we could add a "checkNotNull" in "MathUtils": >>> --- >>> public checkNotNull(Object obj) { >>> if (obj == null) { >>> throw new NullPointerException(); >>> } >>> } >>> --- >>> Wouldn't that satisfy all needs (ability to set a breakpoint and no factory >>> methods)? >> >> No the check may succeed or not, so sometimes these methods do return. > > I'd say that they return most of the time, and that's fortunate... :-) Sorry, I misunderstood what you were writing. I was still talking about the changing the createXxxException (which only creates) into throwXxxException (which creates and throws), not about checkXxxCondition (which checks, creates and throws). > >> What I had in mind was something like: >> >> public static void throwNPE() { >> throw new MySpecialNPE extends NullPointerException() { >> // my special code here >> }; >> } >> >> Such a method *never* returns but on the caller side, the compiler, and >> the checking tools don't know it. Typically when you have code like: >> >> int var; >> if (obj != null) { >> var = obj.getVar(); >> } else { >> throwNPE(); >> } >> >> // use var >> >> Then tools will complain that var may not be initialized, which is >> false. However it is only because throwNPE never returns that it is false. > > Personally, I don't like this kind of syntax. The good programming rule is > to assign at declaration. [Unfortunately, one is sometimes forced to write > in this way and most often than not because of checked exceptions!] > >> Another way to put it that would probably work is: >> >> public static void checkNonNull(Object o) { >> if (o == null) { >> throw new MySpecialNPE extends NullPointerException() { >> // my special code here >> }; >> } >> } > > How is this different from my version above? It's the same, I simply get confused. So go for it, but including the specialization and localization part that was in the former createxxxException. So basically we add an if (obj == null) wrapper aroud the 2.1 code. best regards, Luc > >> Then the caller would do: >> >> checkNonNull(obj); >> int var = obj.getVar(); > > That's exactly the intended usage! > > > Gilles > > --------------------------------------------------------------------- > To unsubscribe, e-mail: email@example.com > For additional commands, e-mail: firstname.lastname@example.com > > --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: firstname.lastname@example.com
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First day of school August 9, 2017
For up to date back to school information including:
Book Rental
and more...
Click here: Back to School
Find supply lists and more back to school information on your school's website.
WCSC Employees
As of June 5, our new email system has been activated. You can find your old email under Employee > Old Email.
Warrick County Presents "Big Fish" at Castle High School
July 20-23
Tickets can be purchased at
http://warrickmusical.org/ starting June 21st
Based on the celebrated novel by Daniel Wallace and the acclaimed film directed by Tim Burton, BIG FISH centers on Edward Bloom, a traveling salesman who lives life to its fullest… and then some! Edward's incredible, larger-than-life stories thrill everyone around him – most of all, his devoted wife Sandra. But their son Will, about to have a child of his own, is determined to find the truth behind his father's epic tales. Overflowing with heart, humor and spectacular stagecraft, BIG FISH is an extraordinary new Broadway musical that reminds us why we love going to the theatre – for an experience that's richer, funnier and BIGGER than life itself.
The Warrick County School Corporation Food & Nutrition Department will be participating in the Summer Food Service Program which is funded by the USDA. This program allows us to provide free breakfast and lunch during the summer months when school is not in session to anyone age 18 and younger at areas in the district in which the student population is at least 50% free or reduced. This year we will have three summer feeding sites. Click here for more informaiton
Professional Development fair open to all WCSC teachers and program assistants. Sign-ups and catalog now included.
July 26 & 27, 2017 @ Castle High School
Click to learn more
1. WCSC 2nd Annual PD Fair Catalog
2. Teacher Sign-Up - ERO
3. Non-certified staff/New teachers Sign-Up
I would like to let everyone know of our severe shortage of school bus drivers. We have been able to cover all of our routes up to this point; however we have had to double up some of our runs.
We are searching for interested parties in becoming school bus drivers. We will provide the needed training required to become a driver at no charge to you other than the cost of the license itself, which is $30.00.
Starting pay for a sub bus driver is $63.80/day and after 14 consecutive days jumps to standard pay of $72.28/day. This is for a typical morning and afternoon run consisting of 3-4 hours per day.
This is a great opportunity to learn a skill that can create you a supplemental income and still be off when the kids are not in school. We will be scheduling classes soon. All classes will start at 9:00 am at the Transportation Garage located at 3455 S. Yankeetown Rd. It typically takes 4 weeks of training before you test in Vincennes. You will test on the same vehicle you train in, making it less confusing for you. There will be some additional training needed after passing the skills test, however that can be worked in around your required driving and observing hours behind the wheel. Any questions feel free to give us a call. Our number is 812-897-0495 and you may apply online for the sub-bus driver position.
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The TICOPA protocol (TIght COntrol of Psoriatic Arthritis): a randomised controlled trial to compare intensive management versus standard care in early psoriatic arthritis
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Psoriatic Arthritis (PsA) is estimated to occur in 10-15% of people with psoriasis and accounts for 13% of people attending early arthritis clinics. With an increasing awareness of the poor outcomes associated with PsA and the availability of new effective, but costly, treatments, there is an urgent need to research the optimal treatment for patients with PsA. The aim of the TICOPA study is to establish whether, in treatment naive early PsA patients, "tight control" intensive management with protocol driven therapies and pre-defined objective targets for treatment can improve clinical outcome compared to standard care alone.
TICOPA is a UK multicentre, open-label, randomised controlled, parallel group trial of 206 patients with early PsA. Patients will be randomised on a 1:1 basis to receive either standard care (12 weekly review) or intensive management (4 weekly review) for a period of 48 weeks. Patients assigned to the intensive management group will follow a strict treatment protocol whereby dose continuation/escalation is determined through the objective assessment of the minimal disease activity (MDA) criteria. Patients assigned to the standard care group will have treatment prescribed as felt appropriate by the treating clinician, with no set protocol. The primary objective of the trial is to compare intensive management with standard care in terms of the proportion of patients achieving an ACR 20 response at 48 weeks post-randomisation, in order to determine whether intensive management has superior clinical efficacy. Key secondary outcomes include ACR 50 and 70, PASI 75 and X-ray Van der Heijde score at 48 weeks post-randomisation along with cost-effectiveness at 12, 24 and 28 weeks.
The TICOPA trial will provide direct evidence as to whether the use of early and intensive treatment in PsA in routine clinical care leads to an improvement in patients' disease activity and a reduction in radiological joint damage.
Trial registration
Psoriatic arthritis (PsA) is estimated to occur in 10-15% of people with psoriasis and accounts for 13% of people attending early arthritis clinics
Research in rheumatoid arthritis (RA) has identified the strong link between inflammation and subsequent joint damage with modern imaging
There is little research into the link between inflammation and structural joint damage in PsA. Previous cohort studies in established disease have shown that active swollen joints and previous joint damage are predictors of a future increase in the clinically damaged joint count
Studies in RA using tight control aim for pre-specified low Disease Activity Scores (DAS), and have shown improved disease outcomes
A core set of domains for PsA has now also been agreed by OMERACT
From observational data in PsA, it seems likely that there is a link between inflammation and damage; modern imaging should clarify this situation. Suppression of inflammation using new biological therapies has improved outcomes for people with established PsA. However, there are no therapeutic trials assessing treatment in the early stages of disease before significant joint damage has occurred. The therapeutic concept of "tight control" has never been investigated in PsA despite the fact that this is well established as the optimal treatment in early RA. Combining these concepts of early treatment and tight control of inflammation in a therapeutic trial could further elucidate the role of inflammation and establish the optimal treatment for people with PsA.
With the development and validation of the MDA criteria, a disease specific target for treatment has been established in PsA and the use of the principles of tight control that were used in the TICORA study can now be applied to patients with PsA. The aim of the study is to utilise the MDA criteria in a tight control protocol to treat newly diagnosed PsA. The TICOPA study will generate mechanistic evidence to inform whether there is a link between inflammation and damage and provide pertinent knowledge of the benefit of intensive treatment to provide superior clinical care to patients with PsA and a consequent landmark shift in clinical management similar to that observed in RA resulting in part from the TICORA study.
Study aims
The aims of the TICOPA study are to compare the clinical and imaging outcomes over 48 weeks, and safety outcomes over 52 weeks after commencement of therapy in treatment naïve patients with early PsA receiving either "tight control" protocol-led treatment or usual clinical care. The principle hypothesis is that tight control of inflammation in PsA will lead to an improvement in patients' disease activity and a reduction in radiological damage compared to standard care alone.
Primary objective
To compare intensive management to standard care in terms of the proportion of patients achieving an ACR20 response at 48 weeks post-randomisation, in order to determine whether intensive management has superior clinical efficacy.
Secondary objectives
To compare intensive management with standard care in terms of additional clinical efficacy outcomes at 24 and 48 weeks, including:
• ACR20 (24 weeks), ACR50 and ACR70
• PASI 50, PASI 75 and PASI 90
• Change in Sharp-van der Heijde Score
• Assessment of cost effectiveness at 12, 24 and 48 weeks
• ASAS 20 and ASAS 40
• Change in enthesitis score
• Change in dactylitis score
• Change in mNAPSI
• Change in HAQ
• Change in other scores (including BASDAI, tender and swollen joint counts, patient and clinician VAS scores)
• MDA score
• Comparison of Quality of Life (QoL),using PsAQoL between intensive management and standard care at baseline, 24 and 48 weeks
• Comparison of safety outcomes over the course of the treatment until 52 weeks
• Comparison of imaging efficacy outcomes including change in Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) and ultrasound assessment of disease at 48 weeks in order to assess inflammation and damage (sub-study).
Study design
The TICOPA trial is designed as a randomised, controlled, parallel group, open label, multi-centre clinical trial of 206 patients with recent onset psoriatic arthritis. Patients will be randomised on a 1:1 basis to receive either standard care (12 weekly review) or tight control (4 weekly review) for a period of 48 weeks, with follow-up of safety up to 52 weeks.
Study interventions
Patients assigned to the intensive group will be seen every 4 weeks by the study physician. A strict treatment protocol (see Figure
Figure 1
TICOPA Study Flow Diagram
TICOPA Study Flow Diagram.
Patients randomised to the standard therapy group are treated in a general rheumatology outpatient clinic supervised by a consultant rheumatologist and including trainee rheumatologists working under supervision. These participants are reviewed every 12 weeks or more often if clinically indicated, with no formal measures of disease activity used in clinical decision making. There is no requirement or restriction on prescribing within this arm of the study.
A total of 206 patients will be recruited over a period of 46 months. Eligible patients will be identified from early arthritis clinics and new referrals to rheumatology clinics at eight hospital sites in the UK. Each site will receive an initiation visit by the member of the research team who will fully train local collaborators in the study.
Patients with a consultant diagnosis of psoriatic arthritis less than two years duration will be recruited. Eligibility for the study is determined at a clinical screening visit with a rheumatologist and research nurse. The study team will ensure that the patient satisfies the study inclusion criteria and does not have any of the exclusion criteria listed in Table
Patients will be approached during standard clinic visits and will be provided with a detailed Patient Information Sheet. They will also be provided with a verbal explanation of the trial by the attending medical staff. Patients will be given at least 24 hours to read the information to consider participation. Assenting patients will then be formally assessed for eligibility and invited to provide written informed consent.
Eligible patients participating in the Yorkshire region will be invited to take part in the optional imaging sub-study based in Leeds. Verbal information and a separate Patient Information Sheet will again be provided for the imaging sub-study. Patients will then be invited to provide separate written informed consent for this sub-study.
Non- randomised patients
Participating research sites will be required to complete a log of all patients, over the age of 18 years with PsA screened for eligibility who are not randomised either because they are ineligible or because they decline participation. Anonymised information collected includes age, gender, ethnicity, reason not eligible for trial participation or for declining participation despite eligibility.
Following confirmation of eligibility and written informed consent and completion of baseline assessments and questionnaires, patients will be randomised. Randomisation will be performed by an authorised member of staff at the research site. Patients will be randomised on a 1:1 basis to receive either intensive management or standard care. Randomisation will be performed using minimisation, incorporating a random element, via a central 24-hour automated telephone randomisation system based at the Leeds Clinical Trials Research Unit. The dynamic allocation method should ensure treatment groups are balanced for randomising centre and pattern of arthritis (oligoarticular vs polyarticular).
Pre-treatment investigations
At screening a chest X-ray (CXR) will be performed unless a CXR is available for the patient within the previous 6 months, and this will be checked prior to starting on treatment with methotrexate. If patients are to be prescribed any of the anti-TNF therapies (etanercept, infliximab, adalimumab) then standard screening will apply. Screening for TB will include either a negative Mantoux test or a negative QuantiFERON gold or TB Spot test. In the event of a positive or borderline test, the test is repeated. If this remains borderline or positive, patients are treated with TB prophylaxis (isoniazid 300mg po od and pyridoxine 100mg po od) for a minimum of 2 weeks prior to starting on the TNF therapy. Treatment with isoniazid and pyridoxine is continued for a minimum of 3 months whilst anti-TNF therapy is given.
Patient follow-up procedures
Patients will be treated in the trial for a period of 48 weeks and followed up for a further 4 weeks. Patients in the intensive management arm will attend the tight control clinic every 4 weeks. For patients in the standard care arm, they will attend a general NHS rheumatology clinic according to local practice dictated by the treating physician, which is usually every 12 weeks.
Patients will be followed up from the baseline assessment to 52 weeks post start of treatment. Follow up assessments will involve a full clinical assessment at 12 weekly intervals to 48 weeks; entailing a physical examination, a full clinical disease assessment, concomitant medical history, and obtainment of safety and efficacy bloods. The follow-up assessment will be performed by a research nurse or metrologist blinded to the allocated treatment group. A final safety assessment will then be conducted at 52 weeks. Where possible, trial clinical assessments will be performed at the same visit as the treatment clinic visits.
Patients who have consented to the imaging sub-study will undergo additional imaging assessments (ultrasound, peripheral MRI and high-field MRI) of peripheral joints and entheses.
Cessation or alteration of treatment regimes will be at the discretion of the clinician or the patient. All patients withdrawn from treatment or prescribed alternative treatment will still attend for follow-up assessments to the end of the study unless the patient withdraws consent for follow-up.
As all therapies are routinely used in the care of PsA, we expect that patients will continue on their medication as long as response has been demonstrated. All patients will be offered continuing follow up in the most appropriate rheumatology clinic at their site after the patient completes the study (a specialised PsA clinic where available).
Outcome measures
The primary endpoint of the study is achievement of American College of Rheumatology (ACR) 20 response at 48 weeks. The ACR20 is a composite response measure developed for RA and requires an improvement of at least 20% in tender and swollen joint counts and a 20% improvement in three out of five criteria from baseline to 48 weeks: (i) patient global assessment of disease activity (VAS); (ii) physician global assessment of disease activity (VAS); (iii) patient assessment of pain (VAS); (iv) Health Assessment Questionnaire (HAQ), and (v) an inflammatory marker (Erythrocyte Sedimentation Rate (ESR) or C-reactive Protein (CRP))
Key secondary endpoints at 48 weeks are: (i) ACR50 and ACR70; (ii) Psoriasis Area Severity Index (PASI) 75; and (iii) modified X-ray Van der Heijde score; and also the cost effectiveness ratio using quality adjusted life year (QALY) outcome measures at 12, 24 and 48 weeks.
The additional secondary endpoints at 24 weeks are (i) ACR20, ACR50 and ACR70 at 24 weeks; (ii) PASI75; and then at 24 and 48 weeks: (iii) ASAS20, ASAS40; (iv) Leeds Enthesitis Index
For the imaging subgroup, endpoints relating to inflammation (ultrasound synovitis, MRI inflammation) and damage (bone erosion or damage on ultrasound or MRI) will be measured at baseline and at 48 weeks.
Sample size calculations
The primary outcome of the study is the proportion of patients who achieve an ACR20 response at 48 weeks. Previous data for patients with PsA
Statistical analysis
An intention-to-treat analysis will be the primary method for analysing and summarising the study data. Patients will be analysed according to the management pathway they were randomised to receive. All formal analyses will be carried out at a 2-sided 5% level of significance.
Primary endpoint analysis
For the primary endpoint analysis, treatment groups will be compared by fitting a logistic regression model to response (whether the patient achieved ACR20 at 48 weeks) adjusted for the minimisation factors arthritis classification and centre. Treatment and covariate estimates and odds ratios with corresponding 95% confidence intervals (CIs) will be presented, along with the p-values. In addition the difference in the proportion of patients achieving an ACR20 response will be presented, with corresponding 95% CIs, and compared using a chi-squared test without continuity correction. Multiple imputation will be used to impute missing primary endpoint data. Sensitivity analyses will be performed in order to assess the consistency of the final conclusions and robustness of the ITT population with missing data imputed by multiple imputation.
A repeated measures analysis will also be performed on the primary endpoint in order to assess ACR20 response over the duration of the study. A multi-level repeated measures model will be used to compare ACR20 scores between treatment groups, adjusted for the minimisation factors. Summary statistics at each follow-up time-point will be presented.
Key secondary endpoint analysis
Logistic regression adjusting for the minimisation factors, will be used to compare the ACR50, ACR70 and PASI75 between treatment arms at 48 weeks.
All additional secondary endpoints will be summarised descriptively by treatment group and time point. No formal statistical testing will be carried out on these endpoints.
Safety analyses will summarise all serious adverse events, suspected unexpected serious adverse events, adverse events, pregnancies and deaths, and will be presented by treatment group and overall.
Economic evaluation
The economic evaluation will assess cost effectiveness using within trial incremental cost effectiveness ratios; the costs and benefits of intensive management to the costs and benefits of usual care over trial duration. Analysis will use overall survival and quality adjusted life years (QALYs) outcome measures. Sensitivity analysis of the incremental cost effectiveness ratio will be undertaken. A scatter plot on the cost effectiveness plane, the 95% cost effectiveness elipse and the cost effectiveness acceptability curve will be presented.
PsA is a common and disabling disease but it has received less attention than RA in both clinical and translational research. Evidence from RA has identified the link between inflammation and subsequent joint damage, leading to an emphasis on early aggressive treatment to reduce joint inflammation causing less joint damage and improved outcome. However, the relationship between inflammation and damage has not been well studied in PsA. Observational studies have shown that swollen joints often subsequently become damaged on X-rays and studies using new, highly effective anti-inflammatory therapies in PsA have shown improvement in disease activity in association with a reduction in levels of joint damage over time. Observational cohort data from Toronto has shown that patients presenting to clinic with less than two years disease duration fared better than those presenting later in terms of ongoing progressive joint damage, despite controlling for baseline joint damage
The effect of treating people with more intensive therapies to ensure that their joint inflammation is minimised, will be assessed. It is expected that joint damage will be reduced further in those patients treated intensively, therefore preventing disability. This therapeutic trial will provide direct evidence to inform the use of early and intensive treatment in PsA to ensure improvement in patients' disease activity and a reduction in radiological joint damage. In addition, the detailed imaging assessments used during the study aims to advance our mechanistic understanding of the relationships between inflammation, damage and bony proliferation in PsA.
Evidence of the benefit of intensive treatment from the TICOPA study should cause a similar shift in routine practice to that seen in RA to provide superior clinical care to patients with PsA.
Time plan for the TICOPA study
Patient recruitment began in May 2008 at one site (Leeds Teaching Hospital NHS Trust); a total of 206 patients have been recruited across eight centres, and the trial closed to recruitment on 21st March 2012. The trial is currently in follow-up until March 2013.
Ethical consideration
Ethical and governance approval for this study has been obtained from the Northern and Yorkshire Research Ethics Committee (ref 07/H0903/72) and the Leeds Teaching Hospitals NHS Trust respectively. The trial progress is monitored by an independent Data Monitoring and Ethics Committee (DMEC) and Trial Steering Committee (TSC).
ACR: American college of rheumatology; ADR: Adverse drug reaction; AE: Adverse event; AMRIS: Arthritis magnetic resonance imaging score; ANA: Anti-nuclear antibody; ASAS: Assessment in ankylosing spondylitis; AST: Aspartate aminotransferase; BASDAI: Bath ankylosing spondylitis disease activity index; BNF: British national formulary; BSR: British society of rheumatology; CI: Chief investigator; CRF: Case report form; CRP: C-reactive protein; CTCAE: Common terminology criteria for adverse events; CTRU: Clinical trials research unit; CXR: Chest x-ray (radiograph); DAS: Disease activity score, 4 variable using either ESR or CRP; DMARD: Disease modifying anti-rheumatic drug; DMEC: Data monitoring and ethics committee; dsDNA Ab: Double stranded DNA antibodies; EUC: Electrolytes, urea & creatinine; FBC: Full blood examination; GCP: Good clinical practice; GDA: Global assessment of disease activity; GH: Patient's general health visual analogue scale (VAS); GRAPPA: Group for assessment of psoriasis and psoriatic arthritis; HAQ: Health assessment questionnaire; Hb: Haemoglobin; IA: Intra-articular; IB: Investigator brochure; IMP: Investigational medicinal product; IV: Intravenous; LDCI: Leeds dactylitis instrument; LEI: Leeds enthesis index; LFT: Liver function tests; MASES: Maastricht ankylosing spondylitis enthesitis scale; MDA: Minimal disease activity; MEI: Mander enthesitis index; Mg: Milligrams; mNCA: Model non-commercial agreement; MREC: Main research and ethics committee; MRI: Magnetic resonance imaging; MTX: Methotrexate; mNAPSI: Modified nail psoriasis severity index; NAPSI: Nail psoriasis severity index; NICE: National institute for health and clinical excellence; NSAID: Non-steroidal anti-inflammatory drug; NSF: National Psoriasis Foundation; OD: Once daily; PASI: Psoriasis area severity index; Phys VAS: Physical visual analogue scale; GDA: Physician global assessment of disease activity; OMERACT: Outcome measures in rheumatology clinical trials; PI: Principal investigator; PO: Per os - Oral; PsARC: Psoriatic arthritis response criteria; PsAQoL: Psoriatic arthritis quality of life; PsAMRIS: Psoriatic arthritis magnetic resonance imaging score; PSSRU: Personal social services research unit; Pt VAS GDA: Patient global assessment of disease activity; PV: Plasma viscosity; QoL: Quality of life; RBC: Red blood cell (count); REC: Research ethics committee; SAE: Serious adverse event; SAR: Serious adverse reaction; SC: Subcutaneous; SGOT: Serum glutamic-oxaloacetic transaminase; SmPC: Summary of product characteristics; SUSAR: Suspected unexpected serious adverse reaction; TB: Tuberculosis; TNF: Tumour necrosis factor; ULN: Upper limit of normal; US: Ultrasound; VAS: Visual analogue scale; WBC: White blood count; WCBP: Woman of child bearing potential; WCC: White cell count; WHO: World health organization; Wk: Week.
Competing interests
Laura Coates has received research funding and/or honoraria from Abbott, Janssen, MSD, Pfizer and UCB. The authors declare that they have no competing interests.
Authors' contributions
PH and LC conceived the study, and participated in its design and coordination. LC also led the drafting of the manuscript. NNC was responsible for the coordination of the study and led the drafting of the protocol. SRB participated in the design of the study protocol with responsibility for the design of the statistical analysis of the study. SB is responsible for providing statistical supervision for the study. LMcP has produced the statistical analysis plan and is responsible for conducting the statistical analysis and reporting of the study. SP participated in the overall design of the study. AM participated in the coordination of the study. CH participated in the design of the study protocol, with particular responsibility for the health economics. HC and JL are primarily responsible for the acquisition of clinical data. ES was responsible for the overall management of the study and for the drafting of the protocol. PE and PGC participated in the design of the study protocol. All authors were involved in the protocol drafting and contributed to and approved the final manuscript.
This study is funded by Arthritis Research UK (Reference Number: 18825).
This report is independent research commissioned by Arthritis Research UK. The views expressed in this publication are those of the authors and not necessarily those of the NHS, Arthritis Research UK or the Department of Health.
A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience
Mortality studies in psoriatic arthritis: results from a single outpatient center, II. Prognostic indicators for death
Longitudinal study of clinical and radiological progression in psoriatic arthritis
Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis
Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial
Progression in psoriatic arthritis: role of time varying clinical indicators
Predictors for radiological damage in psoriatic arthritis: results from a single centre
Clues to the pathogenesis of psoriasis and psoriatic arthritis from imaging: A literature review
Minimal disease activity for rheumatoid arthritis: a preliminary definition
Consensus on a core set of domains for psoriatic arthritis
Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment
Frequency, Predictors, and Prognosis of Sustained Minimal Disease Activity in an Observational Psoriatic Arthritis Cohort
Validation of minimal disease activity for psoriatic arthritis using interventional trial data
American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials
Performance of response criteria for assessing peripheral arthritis in patients with psoriatic arthritis: analysis of data from randomised controlled trials of two tumour necrosis factor inhibitors
Measuring clinical enthesitis in psoriatic arthritis: assessment of existing measures and development of an instrument specific to psoriatic arthritis
Assessment of enthesitis in ankylosing spondylitis
Measuring dactylitis in clinical trials: which is the best instrument to use?
Pre-publication history
The pre-publication history for this paper can be accessed here:


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All that time off could not be seen in Coosa volleyball's first match in the Class AA state playoffs Tuesday.
The same Lady Eagles who tore through Area 3-AA came up big at home, rolling to their third straight Elite Eight appearance.
Coosa faced few struggles in the opening game but improved as the match went on, defeating Toombs County 25-16, 25-13, 25-11.
The home team prevailed thanks to control at the net and excellent serving.
"We started out a little slow, so we made sure the girls were talking and communicating," Coosa coach Nic Hann said. "As they starting communicating, those little things started to fall into place and we just started to roll."
Taylor Roberts and Kasey Thacker led Coosa with 12 kills each, while Thacker also led the team with four aces. Debra Barker led the team with 10 digs and 14 assists, and Tori Overby recorded nine kills and six digs.
Each game followed a pattern with Coosa getting a good start, letting things cool down until the midway point and then finishing the Lady Bulldogs. Toombs seemed to be down as the match went on while Coosa got stronger.
Despite going 17 days between matches, the Lady Eagles looked efficient as ever. Players like Thacker, Overby and Roberts dominated at the net and the team combined for 18 aces.
"For most of the past week, all we have worked on is serving," Hann said. "Just working on the fundamental stuff so we can limit turnovers as much as possible."
Coosa (39-9) began the first game with a 9-3 run, but Toombs fought back and got the score to 14-11 before Hann called a timeout. The Lady Eagles bounced back behind an emphatic home crowd, winning the next five points and eventually winning the game by nine.
Toombs County stayed in the second game for most of its length, but Coosa would finish on an 11-2 run to take a 2-0 lead. The Lady Eagles finished off the Bulldogs when it jumped out to a 10-1 lead in the third game and never looked back.
Despite a successful season, Hann had cited finishing games as one of Coosa's few Achilles' heels. That certainly was not a problem Tuesday, a welcome sign during the most important part of the season.
"Finishing has certainly been our weakness through the season," Hann said. "So to see us finish with those big runs to end each game, that means a lot."
The Lady Eagles now wait to find out who they play next as the GHSA ranks the remaining AA teams entering the quarterfinals before placing them in the championship bracket.
Whoever it is, Coosa will get ready by simply improving on the biggest thing it can control — itself.
"We just keep worrying about us. We don't worry about who is on the other side of the net," Hann said.