text:
Dynamics of muscle fibre growth during postnatal mouse development
Postnatal growth in mouse is rapid, with total skeletal muscle mass increasing several-fold in the first few weeks. Muscle growth can be achieved by either an increase in muscle fibre number or an increase in the size of individual myofibres, or a combination of both. Where myofibre hypertrophy during growth requires the addition of new myonuclei, these are supplied by muscle satellite cells, the resident stem cells of skeletal muscle.
Here, we report on the dynamics of postnatal myofibre growth in the mouse extensor digitorum longus (EDL) muscle, which is essentially composed of fast type II fibres in adult. We found that there was no net gain in myofibre number in the EDL between P7 and P56 (adulthood). However, myofibre cross-sectional area increased by 7.6-fold, and length by 1.9-fold between these ages, resulting in an increase in total myofibre volume of 14.1-fold: showing the extent of myofibre hypertrophy during the postnatal period. To determine how the number of myonuclei changes during this period of intense muscle fibre hypertrophy, we used two complementary mouse models:
Postnatal fast muscle fibre type growth is divided into distinct phases in mouse EDL: myofibre hypertrophy is initially supported by a rapid increase in the number of myonuclei, but nuclear addition stops around P21. Since the significant myofibre hypertrophy from P21 to adulthood occurs without the net addition of new myonuclei, a considerable expansion of the myonuclear domain results. Satellite cell numbers are initially stable, but then decrease to reach the adult level by P21. Thus the adult number of both myonuclei and satellite cells is already established by three weeks of postnatal growth in mouse.
The first 3 weeks of postnatal life in mouse is a period of intense growth, with body weight increasing 7-8 fold, half of which is accounted for by the increase in skeletal muscle
The new myonuclei required during postnatal muscle growth are provided by muscle satellite cells
There is however, a lack of data in mouse from the first two postnatal weeks, effectively missing, what studies suggest, to be the most dynamic period of postnatal growth. By using isolated myofibres from genetically modified mice
Here, we report that total myofibre number in EDL remained unchanged between P7 and P56, while myofibre cross-sectional area increased by 7.6-fold and length by 1.9-fold, resulting in an expansion in myofibre volume of 14.1-fold. Using two independent mouse models, we found that myonuclear accretion in EDL myofibres occurred only within the first three weeks postnatally, with a 4.9-fold increase between P3 and P21. The number of satellite cells was initially similar to the daily rate of myonuclear addition, with ~14 satellite cells per myofibre until P9, when the calculated mean myonuclear accretion rate is 13.6 nuclei per day. Between P14 and 21, the addition of myonuclei decreased to 5.6 nuclei per day, while the available satellite cells fell from ~10, to ~5, per myofibre. Despite the addition of new myonuclei, the greater proportional increase in myofibre volume meant that the myonuclear domain doubled between P7 and P21 to an estimated 9.2 × 103 μm3. The adult number of myonuclei and satellite cells is established by three weeks of postnatal development. Thus the calculated mean myofibre volume increases 3-fold between P21 and P56 (adulthood), without the net addition of new myonuclei, resulting in a further significant expansion of the myonuclear domain in fast myofibres, to an estimated 26.5 × 103 μm3.
Total myofibre number does not change during postnatal growth of EDL muscle
Muscle growth can be achieved by an increase in myofibre number and/or an expansion of individual myofibres. To first examine if hyperplasia of the EDL contributed to muscle growth during the postnatal period in mouse, we counted the number of myofibres contained in the mid-belly section of muscles dissected from P7, P14, P21 and P56 (adulthood) mice on haematoxylin and eosin stained (Figure
Figure 1
EDL myofibres from growing and adult mice
EDL myofibres from growing and adult mice. Entire EDL muscles from P3, P7 (a), P14, P21 and P56 (b)
Table 1
Number of myofibres and satellite cells in EDL muscle sections
±68 (3)
±105 (5)
±30 (3)
±71 (3)
±4.1 (3)
±6.6 (5)
±10.0 (3)
±33.7 (3)
±14.3 (3)
±2.4 (5)
±5.4 (3)
±0.3 (3)
Myofibres and satellite cells (identified by X-gal staining) were counted per cross section at mid-belly level, and cross-sectional area was measured from at least 100 myofibres, from each of three
Myofibre dimensions increase significantly during postnatal EDL growth
To assess myofibre hypertrophy, we first determined cross-sectional area of myofibres from mid-belly muscle sections of EDL between P7 and P56 (Figure
Figure 2
Postnatal growth dynamics of EDL myofibres
Postnatal growth dynamics of EDL myofibres. Measuring myofibre cross-sectional area from mid-belly EDL muscle sections showed that there was a significant (ANOVA:
Table 2
Summary of the growth dynamics of EDL myofibres
±43.8 (20)
±66.0 (31)
±57.8 (36)
±70.7 (42)
±83.9 (31)
±0.08 (764)
±0.07 (947)
±0.07 (969)
±1.4 (71)
±2.0 (61)
±2.4 (204)
±3.5 (111)
±4.7 (78)
±0.7 (61)
±0.4 (204)
±0.3 (111)
±0.3 (78)
Data are mean ± SEM (n: number of myofibres) from 3 ×
To determine the length of muscle fibres, we used collagenase digestion to isolate viable myofibres from EDL muscles of
Myonuclear accretion in EDL myofibres is complete by P21
To determine both the rate of myonuclear addition and the point at which the myofibre attains its full adult complement of myonuclei, we used two complementary mouse models. The
Figure 3
Identification of myonuclei and satellite cells from growing
Identification of myonuclei and satellite cells from growing
Analysis of myonuclei per muscle fibre between P3 and P56 (Figure
Myonuclear domain increases throughout postnatal development
Having both measured the mean myofibre length and counted the total number of myonuclei per myofibre from the same mice during postnatal growth, we could determine the number of myonuclei per unit myofibre length (Table
Table 3
Myofibre volume and myonuclear domain during growth of EDL myofibres
Mean total myofibre volume was calculated from multiplying mean myofibre length by mean myofibre cross-sectional area at each age. Myonuclear domain was derived by then dividing mean total myofibre volume by the mean number of myonuclei per myofibre at each age.
To obtain an estimate of myonuclear domain that took into account both radial and lengthwise myofibre growth, we then divided mean myofibre volume by the mean number of myonuclei per myofibre at each age (Table
Satellite cell number falls during postnatal growth
Having shown that myofibre length, cross-sectional area and number of myonuclei increased significantly during the first three postnatal weeks, we next examined the number of satellite cells over this period, since they are the source of postnatal myonuclei
At P7, each myofibre had a mean of ~14 satellite cells (Table
Figure 4
Satellite cell number steadily decreases from P6, to reach the adult level by P21
Satellite cell number steadily decreases from P6, to reach the adult level by P21. Satellite cells were identified and counted on isolated
We also expressed satellite cell numbers as a percentage of total nuclei per myofibre (Figure
Most studies examining satellite cell numbers during postnatal growth have counted cells on muscle sections (e.g. Ontell et al.
During the first three postnatal weeks in mouse, body mass and total muscle mass both increase almost 3-fold, and fibre length within the tibialis anterior muscle increases by more than 4-fold
We also counted the number of myonuclei per myofibre using two independent mouse models and found that myonuclear addition only occurred during the first three postnatal weeks. We did not observe any regions of obvious higher myonuclear density during postnatal growth, as may have been expected if myonuclei were added preferentially to a particular region of the myofibre. Myonuclear addition occurs mainly at the ends of myotubes during rat foetal developmental myogenesis
The first two weeks are the most active period for the addition of new myonuclei, with myonuclear number doubling twice from P3 to P14. The number of myonuclei increases from ~20% of the adult total, to ~81% by P14, by the addition of over 13 myonuclei per myofibre each day. Since muscle fibres are syncytia, each myonucleus supports a certain volume of cytoplasm in the myofibre - the myonuclear domain. Despite the addition of these new myonuclei between P7 and P14, the myofibre volume increased at a greater rate, so that the estimated myonuclear domain still expanded 1.2-fold. Between P14 and P21, accumulation falls to 5.5 myonuclei per day, with the full adult complement being reached by P21. The greater increase in myofibre volume though, again results in myonuclear domain increasing by a further 1.6-fold. Thus, although the myofibre hypertrophy that occurs during early postnatal growth (P7-P21) is clearly supported by significant myonuclear accretion, the myonuclear domain still doubles due to the greater increase in myofibre volume. These observations refine the electron microscopy studies of Ontell and colleagues
Myofibres do not stop growing at P21 however, when myonuclear accretion ceases; we found that myofibres increased in cross-sectional area by almost 2.5-fold and length by 1.2-fold between P21 and P56, accounting for an approximate 3-fold expansion in myofibre volume. Ontell et al.
The estimated myonuclear domain expanded ~5.7-fold from P7 to P56, consistent with reported increases in growing rat between P14 and P28 in diaphragm
We did not assess muscle fibre type in our study. Myonuclear and satellite cell numbers differ between slow and fast fibre types, with slow generally containing more myonuclei and satellite cells than fast
Since muscle satellite cells are the source of myonuclei postnatally
When satellite cell numbers are expressed as a percentage of total nuclei, their decrease is exaggerated by the rapid increase in myonuclear number (initially ~13 per day). Ontell reported that satellite cells account for 11% of sublaminal nuclei at P14, which decreases to 5% by P56
Associating satellite cell and myonuclear number uncovered an interesting correlation: in the early postnatal period (before P9), the number of satellite cells per fibre is similar to the rate of myonuclear addition each day. There were ~13 satellite cells per myofibre until P9, when the mean addition of myonuclei was 13.6 per day. Since the satellite cell number is relatively stable over this period, it implies that most satellite cells are undergoing asymmetric divisions, each giving rise to both a myonucleus and a new satellite cell, as first suggested by Moss and Leblond in 1971
Each satellite cell producing a single myonucleus and self-renewing each day indicates a cell cycle time of approximately 24 hours. It is a crucial to know however, how many of these satellite cells are actually proliferating? Pulsing with BrdU twice daily between P3 and P10, revealed that 78% of satellite cells in mouse EDL were labelled at P10, so had undergone at least one cell division during this period
Interestingly, it has recently been shown that the transcription factor Pax7 is essential for satellite cell function up to ~P21
Since the total myofibre content of EDL does not change during the first three weeks of postnatal life, muscle growth is achieved by myofibre hypertrophy, which is accompanied by the addition of significant amounts of new myonuclei (~5 fold increase). Despite this increase in myonuclear number during this period, the myonuclear domain still doubles in size. The number of satellite cells per myofibre is similar to the daily myonuclear accretion rate until P21, when the adult configuration of myonuclei and satellite cells is established. The significant myofibre hypertrophy that continues from P21 to adulthood therefore, occurs without the net addition of myonuclei, so results in a large (3-fold) expansion of the myonuclear domain.
Myofibre isolation
Animal husbandry, breeding and experimental procedures were passed by the Ethical Review Process Committee of King's College London, and were carried out in accordance with British law under the provisions of the Animals (Scientific Procedures) Act 1986. Postnatal mouse age (P) was calculated with the day of birth being designated as P0. Age-matched male and female
To visualize β-galactosidase activity, fixed myofibres were incubated overnight (
Counting myonuclei and satellite cells
Total myofibre nuclei (DAPI-positive plus β-galactosidase-positive), total myonuclei per myofibre (DAPI-positive minus β-galactosidase-positive for
Measuring myofibre and sarcomere length
For measurement of myofibre length, images were captured on a Leica MZ16F dissecting microscope using an Olympus DP70 camera, and analysed using ImageJ software (NIH - version 1.42q). Myofibre length was measured from between 19 - 41 isolated myofibres each from at least 3 mice per time point. For measurement of sarcomere length, brightfield images along myofibres were taken on a Zeiss Axiophot 200 M microscope and analysed using NIH Image J software
Muscle cryosectioning and staining
The muscular anterior compartment (tibialis anterior (TA) and EDL muscles) of at least 3
On cryosections from the mid-belly level of the EDL, haematoxylin-eosin or immunostaining for laminin were performed to delimit myofibres for counting. Primary antibody used was a polyclonal rabbit anti-Laminin IgG (Sigma L-9393, 1:200) visualized using Alexa Fluor 594, goat anti-rabbit IgG (Invitrogen A11037, 1:200). All antibodies were diluted in Phosphate Buffered Saline (PBS) and sections were first incubated with the primary antibody in a humidified closed incubation chamber at room temperature for 1 h. After 3 rinses with PBS, the primary antibody was localised with the secondary antibody applied for 1 h, at room temperature. Sections were mounted with Vectashield mounting medium (Vector Laboratories, Inc.) containing 100 ng/ml DAPI and examined using a Zeiss Axiophot 200 M microscope. To identify satellite cells, cryosections of EDL from
Determination of myofibre number and cross-sectional area
Images were made of entire cross-sections of laminin immunostained or haematoxylin-eosin stained mid-belly EDL muscles from 3 mice at each age and total myofibre number determined. Cross-sectional area was determined by measuring at least 300 myofibres in total from at least 3 mice per time point using images from cryosections of mid-belly level EDL. Measurements were obtained using NIH Image J software
Data Analysis
Data were processed using Microsoft Excel and statistical analyses performed using SPSS v16.0. Data are presented as mean ± SEM. Comparisons of means were made using ANOVA with Tukey's HSD post-hoc testing and regression analysis was performed for goodness-of-fit. All data analysed by ANOVA satisfied homogeneity of variance, as defined by Levene's Statistic (p < 0.01). Significance was determined as at least p < 0.05. Some data is also presented in graph form to better illustrate the regression analysis.
Authors' contributions
RBW participated in the design of the study, carried out the majority of the experimental work, performed the statistical analysis and helped draft the manuscript. A-SB carried out the analysis on number of myofibres and satellite cells on muscle sections. VFG measured myofibre and sarcomere length and cross-sectional area, and contributed to writing the manuscript. PSZ conceived the study, participated in its design and coordination, and drafted the manuscript. All authors read and approved the final manuscript.
RBW and ASB received funding from the Muscular Dystrophy Campaign (RA3/762 -
Quantitative analysis of neonatal skeletal muscle functional improvement in the mouse
Increase in the Number of Nuclei and Weight in Skeletal Muscle of Rats of Various Ages
Formation of primary and secondary myotubes in rat lumbrical muscles
Myosatellite cells, growth, and regeneration in murine dystrophic muscle: a quantitative study
Satellite cells and myofiber growth in the rat soleus and extensor digitorum longus muscles
Mitosis during postnatal growth in skeletal and cardiac muscle of the rat
Nature of dividing nuclei in skeletal muscle of growing rats
Satellite cells as the source of nuclei in muscles of growing rats
Satellite cell of skeletal muscle fibers
All muscle satellite cells are equal, but are some more equal than others?
The organogenesis of murine striated muscle: a cytoarchitectural study
Population of muscle satellite cells in relation to age and mitotic activity
A quantitative study of the satellite cell population in postnatal mouse lumbrical muscle
Satellite cell proliferative compartments in growing skeletal muscles
Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells
The timing between skeletal muscle myoblast replication and fusion into myotubes, and the stability of regenerated dystrophic myofibres: an autoradiographic study in mdx mice
Satellite cells are mitotically quiescent in mature mouse muscle: an EM and radioautographic study
A comparison of muscle precursor replication in crush-injured skeletal muscle of Swiss and BALBc mice
Muscle satellite cell numbers during the postnatal period
Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells
Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements
Gamma irradiation prevents compensatory hypertrophy of overloaded mouse extensor digitorum longus muscle
Effect of neonatal denervation on the distribution of fiber types in a mouse fast-twitch skeletal muscle
Myosin heavy chain isoforms in postnatal muscle development of mice
Kinetics of myoblast proliferation show that resident satellite cells are competent to fully regenerate skeletal muscle fibers
Sarcomere length-dependence of activity-dependent twitch potentiation in mouse skeletal muscle
Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice
During secondary myotube formation, primary myotubes preferentially absorb new nuclei at their ends
Repression of myosin isoforms in developing and denervated skeletal muscle fibers originates near motor endplates
Myonuclear domain size varies along the lengths of maturing skeletal muscle fibers
Response of rabbit skeletal muscle to tibial lengthening
Gene expression in muscle in response to exercise
Developmental effects on myonuclear domain size of rat diaphragm fibers
Essential role of satellite cells in the growth of rat soleus muscle fibers
Myonuclear domain size and myosin isoform expression in muscle fibres from mammals representing a 100,000-fold difference in body size
Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice
Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity
The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles
Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women
Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains
Pax7 reveals a greater frequency and concentration of satellite cells at the ends of growing skeletal muscle fibers
Regulation of skeletal muscle fiber size, shape and function
Modulation of myonuclear number in functionally overloaded and exercised rat plantaris fibers
Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells
A role for the myogenic determination gene Myf5 in adult regenerative myogenesis
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Proliferation of muscle satellite cells on intact myofibers in culture
Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements
X chromosome-linked muscular dystrophy (mdx) in the mouse
Culturing satellite cells from living single muscle fiber explants
Isolation and grafting of single muscle fibres


text:
|By Avatarfan0102
|Part of the The Adventures of Qi continuity.
|Liu (The Adventures of Qi)
|Biographical information
|Birth place
|Physical description
|Hair color
Light brown
|Eye color
|Personal information
Jim, Piaolian, Maia
|Chronological and political information
|First appearance
Liu is the son of Jim and Piaolian and is a master waterbender. He met Qi in the Si Wong Desert and has been travelling the Earth Kingdom with her ever since.
Early Life
Liu was born and raised in Ba Sing Se alongside his twin sister: Maia. He discovered waterbending at an early age and began training, eventually mastering it before the age of seventeen.
Meeting Qi
Liu and his family were flying over the Si Wong Desert when they noticed a crashed airship and several people screaming for help. Liu and his sister descended from the airship and found Qi and Huo. Huo had no memory of who he was at the time. They introduced themselves as Maia and Liu and explained how they were siblings. Qi introduced herself and Huo and explained how they wanted to go to Ba Sing Se to restore Huo's memory. When Qi saw a sand dune moving, she nervously asked what was going on. Maia explained how it was a sandshark that might eat everyone up. The siblings invited everyone on board so that they could head to Ba Sing Se together.
In the City of Ba Sing Se
While they were travelling to Ba Sing Se, Qi struck up a conversation with Maia and Liu. She told them how they were looking for the Avatar and they were hoping that the Avatar might be in Ba Sing Se. Maia then delightedly said how she and her brother were from Ba Sing Se and they were returning home from a holiday to the Northern Water Tribe. When Qi asked what Ba Sing Se was like, Liu said it wasn't good. He explained how there had been a civil war, so former Earth King Wu's grandson had taken the throne. He said how the current Earth King was even worse than Hou-Ting, which shocked Qi. They were soon approached by Jim and Piaolian, who explained that they were arriving in Ba Sing Se.
When they were flying over Ba Sing Se, Liu noticed Qi staring in awe at the mega city and saying that it was "amazing." When they landed, Maia and Liu took them to a famous hospital in the Middle Ring that was only ten years old. Inside, the receptionist told them to go to the sixth floor, but when they all went, the receptionist said only Huo could go.
When Huo didn't come back down, Qi began to worry. Maia tried to comfort Qi, but Liu succeeded in making her even more worried. Eventually, a doctor came to them and said there was an attack on the sixth floor. Qi nervously asked the doctor about Huo, who said that he was missing. Qi immediately used her spiritual projection to locate Huo, who was kidnapped and taken to an old abandoned house. When Qi awoke, she told the siblings of Huo's location.
The three took a train to the Lower Ring, where they got off. Qi took the siblings down a dark alley that soon led to the house where Huo was being kept. Qi noticed that Aimei was standing guard, but she soon came up with an idea to distract the princess. Qi awoke soon and cheekily said how Aimei was gone. Now Aimei was gone, Qi managed to lead Maia and Liu into the house, where they began to fight Cici, Wang and Sha. In his fight with Cici, he quickly began to lose. Cici stole all of Liu's water, making him defenceless. Liu dodged countless disks of ice from Cici, and was beginning to lose when Maia and Qi jumped in and saved him.
When Sha and Wang were defeated by the others, Qi ran over to Huo and freed him. Just as they were about to leave, Aimei returned. Angered, Aimei summoned up four augmented fire rings and ten simultaneous fire whips, making it nearly impossible to defeat her. Knowing when to flee, Qi smacked Aimei in the face with air, temporarily stunning her before blasting Maia and her friends to safety with air propulsion.
The four soon came to a stop when they fell next to a pond. When they recovered, everyone thanked Qi for getting them out alive. Qi just said how she was happy to help. When Maia was confused about what to do next, Qi said how they were going to visit the Earth King and ask him about the Avatar.
Several days later, Liu and his friends had managed to arrange a meeting with Earth King Shoo's adviser: Xu. They arrived at Xu's house and he took them to the living room where they struck up a conversation. Xu explained how the Avatar was not in Ba Sing Se, much to everyone's disappointment. Nevertheless, Qi wanted to meet with Shoo and get him to send troops to help look for the Avatar. Xu agreed, but said that due to Shoo's tight schedule, the meeting would have to take place in two weeks.
Two weeks later, Xu took the four to the royal palace, which amazed Liu and his friends. When they arrived in the throne room, Shoo asked Maia to explain the plan. Maia said how Qi wanted troops sent around the Earth Kingdom to hurry the search for the Avatar, which Shoo reluctantly agreed to. After the four friends were alone on the streets of Ba Sing Se, Qi and Huo invited Maia and Liu to join them in the search, which they delightedly obliged.
The next day, Qi asked Shoo to take the Avatar to Republic City if he found the Avatar sooner, much to Shoo's surprise. Shoo was unwilling to do this and didn't like Qi's attitude. He therefore decided to fight Qi's group. Before the fight could descend into chaos, Liu and his friends fled onto the airship and took flight.
The Village of Hope
As Huo and Maia both fell ill, Liu and Qi were the only ones that could visit the Village of Hope. When Liu and Qi entered the village, they found it in ruins. Liu was approached by a man who thought that he was with the Earth King, but Qi quickly denied it. She explained how they were on a search for the Avatar. When the man said the Avatar wasn't in the village, he asked for the help of Qi and Liu. He said how a girl from their village named Yaya had been kidnapped and taken to a nearby prison; he wanted Qi and Liu to bust her out.
Liu and Qi came to a river where Liu waterbent a block of ice to travel across. However, the bridge soon crumbled and Liu dived in the pool to investigate, leaving Qi alone. He found a rogue crocodile in the water and quickly froze it in a block of ice.
At the prison, Qi led Liu into the guard room, where they knocked out all the guards and stole their uniform. Pretending to be guards, they walked outside to where all the prisoners were and told all the guards to get inside. However, when they approached the last guard and said that the warden asked him to be inside, the guard turned to them and said that he was the warden. While Liu fought the warden, Qi went to find Yaya. Liu fought with a sword made of ice and eventually trapped the warden in a slab of ice. He and Qi returned to the village with Yaya, where they were greeted like heroes.
The State of Yi
They soon reached the State of Yi, where Liu, Huo, Maia and Qi were greeted by the new governor. The governor gave them a tour of Yi, where they discovered it had modernised in many different ways. After the tour, the governor took Liu and his friends into his office, where he told Liu the Avatar wasn't in Yi. However, their meeting was interrupted by a clerk who told them that Aimei had landed in Yi.
Outside, Qi told the governor to make sure everyone was safe inside their homes, leaving Liu and his friends to fight Aimei's group. Liu began by duelling Wang. Once again, Liu formed his ice sword and used it to fight Wang, but Wang managed to knock Liu unconscious in a matter of seconds.
Seeing Liu unconscious, Maia carried Liu's body onto the airship and left him to rest and recover.
Fanon:The Adventures of Qi
Book One
104. "The Walled City"
105. "Rescue Mission"
106. "Earth King Shoo"
107. "Village of Hope"
108. "The Fate of Yi"
See more
For the collective works of the author, go here.

subset: commoncrawl


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Save North West Leicestershire Post Offices
- Andrew Woodman
- 6 Signatures
- Closed on Dec 12, 2007
- Target:
- Labour
- Region:
- United Kingdom
Since 1997 Labour have overseen the closure of 4,723 post offices. North West Leicestershire has lost many village Post Offices in places such as Blackfordby, Albert Village and Coleorton. Post Office branches are vital if we are to combat both social and financial exclusion, and this Government wants to continue destroy this vital network by closing a further 3000 Post Offices.
Conservative Parliamentary Spokesman for North West Leicestershire Andrew Bridgen advocates the freeing up of subpostmasters and postmistresses, to provide a greater range of products and services, as well as a scheme whereby people with concerns about a range of Government services can use their local Post Office as a kind of 'Government GP'. This can advise on issues such as tax returns, pension entitlements and the opening hours of local pharmacies.


text:
Border collie puppies from working and show lines. Very smart and loving....would make great agility dogs. One male and one female left. 2 months old$800
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Nickname: Eve Posted Breed: Dachshund / Mixed (long coat). ~~Eve is a Dachshund mixture that will need a quiet mature home where there are not a lot…No Price Listed
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Pure AMERICAN KENNEL CLUB chocolate labrador. Parents both on site and are excellent hunters, exceptional family dogs, great temprament, eager to please…$900
Ranch raised AMERICAN Kc registered Old English sheepdogs, parents health tested for PCD, EIC, MDR1, OFA, hips, elbows, eyes, DM, CA. There is a 100% health…$1,800


text:
How to set priority to java elements
I have some experience with wordpress, I'm running a site, but I'm not really an expert, can someone help me to solve this problem?
I had 4 java elements on my index page (if that's how they should be called)
1. The feature slider
2. The Yahoo weather plugin in a sidebar
3. Slimstat plugin
4. java analog clock.
Everything worked fine, however, for some reason the weather widget and the clock failed to load from time to time. That messed my index page: in such case the slider is dead because it waits for those previously mentioned elements to load. The post excerpts are not loaded. I turned off the weather plugin and everything works fine.
Before i get rid of it, is it possible to somehow set the priority, so that the feature slider loads first, while the weather plugin and the clock load last. In such case, everything will be loaded properly and if the weather widget or the clock malfunction for some external reasons, they will not mess everything.
The priority should be like this:
First load the slider
Then load the statistics tool
then the weather report
and the clock
Now it loads the elements from left to right, which means that those in the left sidebar load first. If they fail, everything else is stucked and waits for them
How to set this properly and where? Thank you very very much.
- The topic 'How to set priority to java elements' is closed to new replies.


text:
After rebounding in October, the accounting profession's expectations for economic growth remained healthy this month, according to the November edition of Accounting Today's monthly Accountants Confidence Index.
The 3-Month and the 6-Month ACI had risen somewhat over the summer months before sinking sharply for September, with the short-term figure dipping below the 50 mark that the dividing line between expectations of growth and expectations of contraction. After October's rise, this month's figures remained positive, despite being recorded shortly after the government shutdown.
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Most of you would've heard of the exciting news of Orlando Bloom wanting to play Will in Pirates 5. But how could they write him into the story?
My theory is, is that he seeks Jack's help of leaving the Dutchman to go back to living with Elizabeth.
If you think about Turner returning, it could also mean, Elizabeth, Bootstrap, Pintel & Ragetti.
Please do not comment saying something similar to this, "duh... his story finished in At World's End," I only want to hear on HOW he could be re-introduced.


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Vienna is Austria's capital and largest city located on the east part of the country. Undoubtedly one of the most charming European capitals, Vienna is one of the world's leading cities with the best quality of life in the world. The imperial capital is elegant and cosy with beautiful parks and statues of great musicians.
A picture-perfect Austrian city with Alpine appeal, Innsbruck blends lavish baroque palaces and designer boutiques with old-world taverns and glass-fronted bars. Glittering with crystals and shining slopes, it's steeped in tradition but by no means traditional – as Bögen's all-night parties confirm.
Reviews & ratings Vienna - Innsbruck
"train from Innsbruck to Vienna" Elizabeth b. 29/07/2013
Excellent service being on time, comfortable, impeccably clean and with a good food and coffee service.
Excellent service being on time, comfortable, impeccably clean and with a good food and coffee service.


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Where are the Young People?
For those who didn't hear me speak on Overture 05-05:
"Where are the young people?" As a young woman at General Assembly, this is the question I have constantly been asked. Everyone in this room has either asked this question or been asked this question. I'll tell you where the young people are:
They are not invited to the table by their sessions or presbyteries because the assumption is that 'they wouldn't be able to come due to work.' You know how to fix that? Put in a dependent care policy."
Courtney Steininger
National Capital
The Room Where it Happens
Yesterday was an incredibly long day at General Assembly, so I apologize for my blog post coming in a bit late, but still wanted to talk about all that happened yesterday in "The Room Where it Happens." I will make sure to be more timely with my blog about today!
To frame this blog, I want to make two things clear about my personal background. First, I am Hamilton trash, and played Rev. Holly Ulmer a song from Hamilton while we were driving to a NCP meeting this past winter. Second, I would just like say that I am working to make my own major in Narrative Methods at UMD. As a result, I care deeply about how we tell stories.
Our church is a safe space for all people. This is the story that we, as the PCUSA, want to tell people. But we do little to equip people to act in this manner. Jesus Christ is Lord of the conscious. That is the very definition of reformed theology. We all are equal in the eyes of God and capable of making decisions. With that in mind, we do little beyond making statements. We need to act like we are all equal, and don't ever call someone #justanelder. Both TEs and REs are crucial to the success of our denomination. We, as sisters and brothers in Christ, are all in the room where it happens. Including young people in this church. But our invitation seems less important than the invitation of others in our congregation. What kind of narrative are we telling?
I want to close with something a little more light-hearted sounding, but still deeply serious to me and to our denomination and Jesus' Bride, the Church. "With great power comes great responsibility." Yesterday I heard about a Super-Bible-heroes curriculum that reminds me how important our work is. We are #allministers and What To Fix, PCUSA (or my preferred attention-grabber, #wtfPCUSA) is that we need to empower and equip our ruling and teaching elders to know this. As a YAAD, I struggled yesterday with the environment of my peers and the environment of all GA as my peers in Christ. God the Mother and Father Call us to treat each other well and allow ourselves to be opened to the way of the Holy Spirit. I look forward to committee work and beyond. This can be the counter-narrative at General Assembly.
Peace and Blessings,
Courtney Steininger
L3 Intern
Simple Gifts
Somehow, today I emerged as the new Presbyterian comedienne.
I began my takeover of all L3: Listen, Learn, Lead social media early this morning. From the get-go, I was able to exist at the center of the Presbyterian twitter-verse with gems like my tweet above! In all seriousness, my first proper day at the 222nd General Assembly was amazing and eventful, and above all, was intimately informed by my involvement with L3, how L3 has developed my leadership, and how it has informed my sense of calling.
This week, I am#GA222 and will not be able to attend my Great Uncle Joe's funeral. I remember sitting around the dinner table at my Grandma Marie's giving my political opinions when I was 15 and taking a government class for the first time. Uncle Joe said, albeit in a joking tone, that "Maybe you should be a politician." He had confidence in me and faith in my beliefs that I don't even know if I had myself. In Portland, I reaffirmed my baptismal calling and call as an advisory delegate. In a sense, I am now a politician, though not the type Uncle Joe implied I should be. This memory was brought to mind as we sang "We Shall Overcome" for friends we've had and friends we've lost in our opening worship. I was brought to tears as I recognized that God places clues in our lives about our Calls.
Today, I wanted to talk about these little clues, or "simple gifts" from God, as it were. Sometimes this gift is the ability to make a cute joke, as I did above. And sometimes, the gift is the song, "Oceans," first introduced to me in college by two women on my freshmen year floor. We sang it today as the General Assembly, and I remembered the way that those two women, sophomores who were and are my friends, guides, and mentors, affirmed to me that a secular university does not need to make you secular. Indeed, they opened me to new ideas and the new ability to strengthen my faith in that setting.
I am also incredibly grateful for God pushing me towards the campus ministry I got involved with. Certainly, without Rev. Holly Ulmer, our Chaplain, I would never have gone to a presbytery meeting and I would not be sitting in Portland right now. This was another simple gift. The first activity that I remember doing with United Campus Ministry during the second or third week of my freshman year was to think of all of God's signs that point to your calling. I had no idea of what to say. Today I saw directly all of God's "simple gifts" that brought me to this Call at GA. The only way I was able to notice them today was because of my involvement in UCM and L3:Listen, Learn, Lead. This leadership development and campus ministry experience "equipped me" to serve today and in the upcoming week.
This is what the Presbyterian Church (USA) has done for me. I only hope that after #GA222, PCUSA will be empowered to do this for so many other young adults too. I look forward for the week ahead and will be on twitter constantly and here once a day!
I would also like to give a special shout-out to Denise Anderson and Jan Edmiston for being elected as the Presbyterian Church of the United States of America's first EVER CO-Moderators! Just another one of God's gifts to us all! As the YAAD from National Capital Presbytery, I feel especially touched that God put me in this place to know these amazing and special women.
Peace and Blessings,
Courtney Steininger
L3 Intern
Defining "Safe Space"
How do we build community on a college campus? How can congregations build a sense of belonging for college students?
When I tell people that I intern for a chaplain, people are often confused about what exactly I do. As an intern for L3: Listen, Learn, Lead, I am called to create a community and a safe space for student reflection. The first meeting of the spring 2016 semester began with my establishing an unwritten contract to denote the conversation as a "safe space." Despite being crafted by Millennials in a university setting, this contract did not refer to the language we used around each other, but rather the way we ourselves would allow ourselves to be open to the opinions of others. Personally, part of my idealized version of a university experience includes creating a safe space for students to discuss issues that matter to them.
Sometimes this means blogging and sometimes it means facilitating discussions on calling. During this time of tragedy, it meant coordinating a service and space for the College Park community to consider the events that occurred. "United in Compassion and Hope: Gathering in Response to the Orlando Tragedy" formed out of a campus need for a "safe space." This space is not secular, but rather raises our interfaith and secular diversity. While the term "Safe Space" is weighted in our society and often viewed as a new-age, liberal term that refers to a sterilized environment where PC culture is propagated, there is no reason that this should be the case, however. A Safe Space is "a place where anyone can relax and be able to fully express, without fear of being made to feel uncomfortable, unwelcome or unsafe…a place where the rules guard each person's self-respect and dignity and strongly encourage everyone to respect others."
One of the official goals of L3: Listen, Learn, Lead is "Providing a safe space and opportunity to experience an inclusive, supportive community as they explore the meaning of vocation for their lives, in the midst of big questions and often anxiety concerning their futures." The actualization of this is much more difficult, however. Everyone has the right to feel safe and secure and the right to voice their personal opinion, as well as explore other opinions. That being said, to create the proper environment for this space, significant community building must occur. After our annual retreat last semester, there was certainly a deepened sense of community among L3 participants. This raises questions though: "Was truly just forced time together all we needed to form a community? How do you actually build community?" While rules can define and maintain a Safe Space, rules do not a safe space make. Regardless, it is hard to not list some rules in a blog, so here are my top three L3 community and safe-space building guidelines that I recommend for your careful and prayerful consideration, especially as local congregations interacting with our L3 students as they spend their summers at home!
- Acknowledge everyone both socially and intellectually
While it is fantastic to create social spaces for young people, it is crucial to remember that young adults, especially college students, are incredibly academically and intellectually driven. Raising these traits in social settings will only further empower them to reach higher levels of understanding.
- Know when to use humor and when to refrain
Millennials are at once an incredibly laid-back generation and an incredibly serious generation. While we may use sarcasm heavily amongst ourselves, we are very careful to know when sarcasm could be offensive. This may lead older adults to think we are obsessed with a PC culture, but this is how we respect those around us.
- Don't segregate
As I mentioned above, there is value in social time for young people. But they also want to interact with the congregation as a whole. They want to network with older congregants who may know more about the field of study they want to pursue. During Wednesday L3 lunch discussions, we had a variety of students participate, from graduate engineering students born in India to sophomore English majors. This group did not lack cohesion, nonetheless, and everyone involved was able to better learn from each other.
Happy Community Building!
Courtney Steininger
L3 Intern
L3 Session Tonight!
Following up on God's unconditional love for us we can have
a special session on prayer:
The Prayer of Recollection (Tradition from St. Teresa of Avila)
"Prayer. . .means taking time frequently to be alone with the
One who we know loves us."
This special prayer tradition which is done individually in silence
involves these steps/parts:
1. Preparation
2. Meeting the Lord
3. Intimate Sharing
4. Conclusion
It's along the theme of L3: Listening practices (how we discern
God's will for us; practicing being in the presence of God.)
Join us tonight in the Memorial Chapel lounge at 6pm!
Happy Easter! Jesus is risen!
Some great places to worship on Easter Sunday!
University Christian Church, Hyattsville
(Christian Church (Disciples of Christ))
Website: http://cucmd.org/
10:45am Disciples of Christ service, with communion served. For all ages in the Sanctuary. Child care provided.
12:00pm Refreshments and conversation in the Narthex.
Riverdale Presbyterian Church, University Park
(Presbyterian Church (U.S.A.))
Website: http://www.rivpres.org/
10:00 a.m. Worship Service
11:00 a.m. Coffee Fellowship
Greenbelt Community Church, Greenbelt
(United Church of Christ)
Website http://www.greenbeltcommunitychurch.org/
10:15 am Worship Service
Followed by Refreshments and Fellowship
Berwyn Presbyterian Church
(Presbyterian Church (U.S.A.))
Website http://www.berwynpresbyterian.net/
11:00 a.m. Worship Service
Followed by Refreshments and Fellowship


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text: Ok so the announcers are just a bit over the top... OK completely over the top but this is how you celebrate a touchdown. Married to my awesome wife Sarah. Have a 11-year old son Will...a 6-year old daughter Emma and my beautiful newborn baby girl Gwen. Contact Call (918) 460-1430 Text BUZZ to 82945 Reply STOP to cancel. Standard text message and data rates apply. Email firstname.lastname@example.com Social


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About the Book
Photographer/Filmmaker Michael Saul takes us into a world of observation and life experiences in this beautiful monograph.
Features & Details
- Category Fine Art Photography
Large Square, 12×12 in, 30×30 cm
20 Pages
- Publish Date Oct 18, 2013
- Language English
- Tags los angeles, las vegas, photo manipulation, nudes, men, gay, nature
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Hi, and I would like to thank all of my loyal readers. My wife has decided that she has found a way to let off a bit of steam, and creativity. She wants to blog.
She will be doing Wordless Wednesdays, posting about life, and much more.
There is also a Mr. Linky section on her site to promote your contests.
Here's the best part… She will be running contests.
I got her a domain name, and set up her blog so that it isn't overwhelmed with junk.
I would like to ask everyone to stop by, and give her a welcoming to the blogging community.
She doesn't have much content there yet, but I promise that I have her on a schedule to keep the site productive. By next week there will be a lot more posts.
Her site is http://www.momsblogs4u.com
Starting a blog is like taking a diet pill. You can't stop once you get started.
Thank you all for bringing her in right.


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Sitter in Plainview
I am a full time sahm of 3 ages 13, 2, and 4 months. We are a fun out going family that loves to do hands on activities, make forts out of blankets, houses with card board boxes, and spend time outside..... are also in the county with a lot of space to run and play.I am cpr and first aide certified. I had been working as a cna until our youngest was born.I am open to any shift and willing to work with you on prices
Sitter Details
|Email Address
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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Nick Kew <n...@webthing.com>
|Re: PR44641: Does patch make sense
|Wed, 19 Mar 2008 22:34:36 GMT
On Wed, 19 Mar 2008 17:08:53 -0500 "William A. Rowe, Jr." <email@example.com> wrote: > > I am *not* worried about some sort of memory leak with the pool used > > by register_hooks. It is the contrary: I am not sure if the > > register_hooks pools gets destroyed / cleared too *early* or in > > between so that we are pointing > > to invalid memory. So please some eyes on this aspect. > > What happens is that a module must register itself during config, and > remove itself from the hash during post-config. Hopefully during the > re-config phase it replaces it's own hash registration. > > If this doesn't happen and the module is removed from the list during > a graceful restart, there will still be a hash entry into it. > > It's possible to do a pconf teardown resetting the hash, but if we > reset while modules are unregistering themselves, we are back to the > original fault. Right, we need to exercise care with pool lifetime. Let me resurrect my previous suggestion: a subpool which we tear down in post_config. We can also set the pool and the hash to NULL, to make debugging easy if we or a module developer screw up. That of course also says modules should NOT deregister themselves! -- Nick Kew Application Development with Apache - the Apache Modules Book http://www.apachetutor.org/
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Domain Associates Tiptoes Into China
Domain Associates, one of the most active U.S. health-care venture firms over the past 25 years, is now scouting out opportunities in China.
The Princeton, N.J., firm recently made its first investment in a Chinese company, teaming up with OrbiMed Advisors and Sequoia Capital to provide $24 million in Series B financing to Eddingpharm (Cayman) Inc., a Shanghai-based company focused on medical-nutrition products and cancer therapies.
U.S. firms such as OrbiMed, Sequoia, Kleiner Perkins Caufield & Byers and New Enterprise Associates have made a strong push to invest in China and Asia in recent years, lifting investment activity in the region.
With the Chinese government working to improve access to health-care services, venture firms see opportunity to back companies marketing drugs, medical devices, diagnostics and other products. Domain has recognized this for some time, but wanted to be sure it had a strategy that suited the Chinese market, according to Partner Brian Halak.


text:
A woman is kidnapped on her honeymoon and her ex-soldier husband endeavors to free her. A kidnap thriller set in New York and Turkey.
This is The Disappearance Of Lenka Wood and you are watching MovieZion
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We have helped thousands of people fight wrongful denials.
Disability Insurance Benefits Basics
Fortunately, when a person buys an individual disability insurance policy directly from an insurance company, in most cases, the law helps experienced attorneys protect their clients' rights. Most individual disability insurance cases can be fought over in court using state laws that favor the person with the policy over the insurance company, or at least provide a level playing field. If the insurance company does something really bad, some states even allow for the person who is wrongfully denied to sue for more than just the benefits, but to sue for bad faith and punitive damages. But those cases are not like more common lawsuits, and those cases can also be extremely complicated.
Attorneys who know about the inner workings of insurance companies, the rules of insurance law, regulations and contracts, all which can vary from state to state, can better represent their clients in court and obtain a favorable outcome.
How do I know if the disability insurance attorneys I hire can take on the really big insurance companies? Eric Buchanan & Associates is a boutique law firm, focusing primarily on disability insurance, ERISA insurance, and similar insurance, like life insurance claims. Because we are a boutique firm with a focused practice area, we have learned the ins and outs of disability insurance law, ERISA law, bad faith law, and insurance law. In fact, we have been so successful that some of our cases have resulted in the law improving to be more helpful for other disabled people who have to fight in court. You can see our list of cases here . Because we limit our practice to this specific area of the law, our team knows what it takes to take on the big insurance companies and win in the right cases. In fact, we have learned so much about the way the big disability insurance companies handle claims that we can help our clients present the best disability insurance claim possible, and if that claim is denied, we know what questions to ask in court and what to prove to help convince a judge or jury that the disability insurance company did not make a fair decision, and that benefits should be paid. Or, by showing the insurance company that we can prove that type of information in court, we can help our clients obtain a good settlement in the right cases.
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text:
Catholic Charities of the Diocese of Green Bay received a Centennial award from Catholic Charities USA for its work in reducing poverty through the Financial Health Program.
To learn more about the Financial Health Program, click here.
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text: 1/20/11 1/20/11 POPSUGAR Fashion Patrick Demarchelier Marc Jacobs's Industrie Drag Editorial Is Now Out in Full Marc Jacobs's Industrie Drag Editorial Is Now Out in Full January 20, 2011 by POPSUGAR Fashion News 3 Shares Chat with us on Facebook Messenger. Learn what's trending across POPSUGAR. View on One Page Photo 2 of 9 Start Slideshow ADVERTISEMENT () Share This Link Copy What's Your Reaction? Thanks for your reaction Don't forget to share this with your friends! ← Use Arrows Keys → 2 Previous Next IndustrieIn The Looking GlassPatrick DemarchelierKatie GrandMarc Jacobs


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DELMAR, Iowa - Corn was damaged in fire at a grain drying bin Thursday morning at the AgVantage FS elevator in Delmar.
Delmar Fire Chief Dick Schneden said flames were coming from the grain bin when employees noticed the fire just after 8 a.m. at 502 Main St. When firefighters arrived, there were no longer any flames and the dryer had been shut down.
Schneden said because of the height of the bin, the Maquoketa Fire Department was called to bring its aerial truck. The Charlotte Fire Department was called for mutual aid, and Welton firefighters were asked to stand by at their station.
"The aerial was used to look in the top of the dryer, but they couldn't see any fire," Schneden said. "They didn't use any water on it."
AgVantage employees began emptying the dryer from the bottom. Schneden said they hauled out some burnt corn, but couldn't say how much was destroyed. "It wasn't that much," the chief said.
Schneden said the cause of the fire is unknown. He said company employees told him they turned on the dryers about 20 minutes before they saw the flames.


text:
by Harold Friend
One of baseball's great off-the-field actions that affect on-the-field results are trades.
Free agency has changed things because most trades now involve players whose salary demands are difficult to meet for some teams, which often results in a star being sent to a rich team for prospects.
It Takes Time to Evaluate a Trade
It takes a few seasons to evaluate a trade, and with all the player movement today, it is difficult to remember the players involved in a trade without, as Casey Stengel used to say, looking it up, but it used to be different,
Major leaguers were traded for other major leaguers, not for prospects. Hindsight illustrates how often experts are wrong.
Hector Lopez and Ralph Terry to the Yankees
On May 26, 1959, the New York Yankees went to their Kansas City friends to obtain infielder Hector Lopez and right-handed pitcher Ralph Terry. In return, Kansas City received the services of right-handers Tom Sturdivant and Johnny Kucks, and infielder Jerry Lumpe.
It was the 14th trade between the teams since the Philadelphia Athletics moved to Kansas City. Most viewed the trade as a toss-up.
Camilo Pascual for Tom Sturdivant
In 1956, the Yankees were about to send Sturdivant to the Senators for 22 year-old right hander Camilo Pascual, who had been 2-12 in 1955.
The Yankees called off the trade at the last minute, and when Sturdivant won 16 games in 1956 and again in 1957, while Pascual struggled, not making the trade was viewed as a sagacious move, but time is the great equalizer.
Camilo Pascual Becomes a Star
Tom Sturdivant developed arm problems, while Pascual developed into an ace, winning 20 games in 1962 and 21 in 1963. Pascual was a solid pitcher until 1969, winning 174 games.
Sturdivant retired after the 1964 season, never winning more than nine games. He finished with 59 career wins.
Johnny Kucks' Short Career
Johnny Kucks met a fate similar to that of Tom Sturdivant.
In 1956, Johnny was an 18-game winner at the age of 22, including a shut out in the seventh game of the World Series, but his career ended after the 1960 season.
He never won more than 8 games in a season after 1956 and won only 54 games.
Jerry Lumpe was a good spray hitter who became a decent second baseman with the's and Tigers, He had his best season in 1962, when he hit .300. Lumpe retired at the age of 34 in 1964 with a .268 lifetime average.
Hector "What a Pair of Hands" Lopez
Hector Lopez did fairly well for the Yankees as a defensively challenged, platooned left fielder. A New York baseball writer dubbed him "Hector 'What a Pair of Hands' Lopez," but Hector was adequate defensively most of the time.
Surprisingly, he never cost the Yankees any significant games, despite his horrible .970 fielding percentage as a left fielder.
Lopez had been a solid hitter with Kansas City. He hit .290 with 15 home runs in his rookie season of 1955, and was batting .281 with six home runs at the time of the trade. He finished the 1959 season with a .283 average and 16 home runs.
His best season with the Yankees was 1960, when he hit .284 with 9 home runs, but when Ralph Houk replaced Casey Stengel, whose sin was getting old, as Yankees' manager, Lopez became a part-time outfielder.
Ralph Terry's Extremes
Ralph Terry was another story. The Yankees signed the 18-year-old Terry in 1953, traded him to Kansas City in 1957, and got him back in 1959. When the trade was made, Casey Stengel thought that the change of scenery might help the disappointing Terry.
"He looked like a fine prospect with us a few years ago, but I understand that after we traded him to the A's, Harry Craft (Athletics' manager) never was quite satisfied with him. Maybe with a fresh start in New York, he'll do better."
Terry went to extremes. He gave up the ninth inning home run that ended the 1960 World Series, and then he shut out the power-hitting Giants in the seventh game of the 1962 World Series.
His major league career began at the age of 20, and he was finished when he was 30, although he hung on for another season.
Bill Veeck and Frank Lane Were Upset
The Hector Lopez trade was not viewed as earth-shattering, but White Sox owner and Indians general manger Frank Lane were upset, because they thought that the trade would help the Yankees.
Veeck and Lane pointed out the number of trades the Yankees had made with their cousins in Kansas City as an example of a questionable situation.
The Yankees lost the pennant in 1959 for the first time since 1954, despite obtaining Hector Lopez and Ralph Terry.
Bill Veeck's Go-Go Sox won the pennant, and Frank Lane's Indians finished second, five games behind the Sox and 10 games ahead of the Yankees.
That winter, the Yankees did make a significant trade with Kansas City. They obtained a left-handed hitting outfielder who many still consider the holder of the record for the most home runs in a single season.
By JOHN DREBINGER. (1959, May 27). Yanks Get Lopez, Terry From A's :Sturdivant, Lumpe and Kucks Traded to Kansas City. New York Times (1857-Current file),p. 40. Retrieved July 31, 2009, from ProQuest Historical Newspapers The New York Times (1851 - 2006). (Document ID: 80581097).


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We ran the Pink Ribbon Fitting Campaign as a store event at approximately 2,000 stores throughout Japan in October. In the campaign, we donated 10 yen for every bra try-on at each store to the Japan Cancer Society (Smile Fund), on behalf of customers. In FY 2015, more than 178,000 customers tried on roughly 500,000 bras.
Also, our Pink Ribbon portal site , linked to store events, carried out the Pink Ribbon Test to have people learn more about breast cancer and feel easy to take part in donating activity (Regardless of whether you get the answers right or not, ¥3 is donated when you answer three questions).
The total amount of donations in FY 2015 from stores and the website combined was around 5.25 million yen.
We also cooperated with the stamp rally and walking event held every year by Pink Ribbon Kyoto, in which around 950 people took part in 2015.
Through the breast cancer awareness-raising program called "Fit for the Cure," which has been implemented since April 2001, we have donated a total of more than 4,400,000 USD to the Susan G. Komen Breast Cancer Foundation for its awareness-raising activities for early detection and screening of breast cancer, postoperative care, and research. We also have held more than 1,300 fitting events at middle to high-end department stores in the U.S. and Canada annually, in which a total of more than 55,000 women (an accumulated total of more than 765,000 women) tried on bras. In these events, we donate two dollars for every fitting regardless of whether or not participants purchase products, and additionally two dollars for every bra or shapewear item that is purchased, on behalf of the participants. The Fit for the Cure program is a very important marketing activity for us. It provides an opportunity for many women to understand the excellent fitting feel and comfort of Wacoal products by trying them on for the first time at these events.
Wacoal Europe served as the headline sponsor of the Intimate Ball which ran in aid of the breast cancer charity Coppafeel. Furthermore, we took part in a Wear It Pink day event for breast cancer awareness month to enhance public awareness for early detection of breast cancer.
Wacoal Europe not only published Pink Ribbon on all of its brand websites to disseminate information on Pink Ribbon, but also featured Pink Ribbon in its internal magazine to improve awareness inside the company.
We carry out various activities in partnership with the government agency All China Women's Federation. For example we created, edited and distributed 300,000 copies of educational pamphlets about early cancer detection to the general public. In addition, we held campaigns to heighten awareness of women's health issues, such as educational seminars designed to increase knowledge about underwear and breast health, in the five major cities of Peking, Chengdu, Shenyang, Shanghai and Xiamen in which around 300 people participated. In FY 2015 we donated around 700,000 RMB to education campaigns conducted by All China Women's Federation in relation to breast health, and 100,000 RMB to education seminars.
In October every year, we distribute brochures that include information on a breast cancer self-examination method, and Pink Ribbon badges free of charge at approximately 100 shops in department stores and at approximately 150 specialty stores, in order to enhance public awareness of educational activities on breast cancer prevention.
We publicize the Pink Ribbon Campaign on the website and through emails to CRM customers, as well as through posts and advertising on Internet blogs and Facebook.
We also provide support for meetings of patients with breast cancer and biannual breast cancer prevention seminars, which are held at major hospitals (Seoul National University Hospital, Samsung Hospital, Yonsei University Hospital, etc.) in Korea.
We distribute the "Breast Health Diary," a brochure explaining the importance of early detection of breast cancer and preventive measures, and recommending breast cancer screening, at individual stores, in order to promote breast cancer screening and foster better understanding of Pink Ribbon activities.
We also provided breast cancer screening services by arranging for screening cars equipped with mammography equipment through the Ministry of Health and Welfare, in collaboration with major department stores and specialty stores. We presented the "Breast Health Diary" and a gift to all participants in the event.
In FY2015, we donated 920,000 yuan NTas support funds, as well as 800 pairs of shorts and 20 sets of pajamas, for use as promotional gifts, to various events held by the Taiwan Breast Cancer Alliance, including the "Swimming Carnival of Sun-Moon Lake" and the "Pink Ribbon Lighting Ceremony."
Indonesia Wacoal did some various activities for Pink Ribbon Campaign this year. We put some material promotions that was given by Wacoal Japan in stores (window sticker, POP). To give more exposure for this message, all the window display decorated with pink theme (manequins wear pink merchandise). And for below the line activities, Indonesia Wacoal collaborated with students of Bina Nusantara - Northumbia School of Design. They decorated some plain bra using their creativity, and all of them collected and displayed in a one giant pink ribbon board. The giant pink ribbon displayed in some malls to attract people, and they asked to join the donation activities by choosing their favorite bra. Beside that, Indonesia Wacoal also collaborated with one of famous designer, Musa Widyatmodjo, to held a charity fashion show, Indonesia Wacoal also cooperate with Roche brand and made a video knowledge about breast health, promoted in instore LCD TV and youtube.
For employees, we hold breast cancer awareness-raising seminars, inviting physicians as lecturers, and provide mammography screening twice a year. We also offer prosthetic breasts and three Remamma bras to individual mastectomized employees every year. For people outside the company, we conduct educational activities for breast cancer prevention for local housewife groups in cooperation with the Bangkholeam District Office (a national cancer center), and provide measurement services for mastectomized women, involving 15 hospitals. We also donated 5,000,000 baht to Khonkaen Hospital to help with construction costs for a cancer center.
The campaign started in January 2004. In FY2015, in order to raise awareness of the Pink Ribbon activities, we created POPs and distributed pamphlets in stores. In addition, we set up a structure in all stores to encourage customer donations. Around HK$60,000 (an accumulated total of HK$240,000) was donated to the Hong Kong Breast Cancer Foundation.
We also hold regular seminars to explain Remamma products and how to wear them at stores and meetings for breast cancer patients.
We place donation boxes at stores and in the office in October every year, and present Pink Ribbon badges to contributors. We donate the collected funds together with donation money from Wacoal Singapore Pte. Ltd. to the Breast Cancer Foundation (Singapore Breast Cancer Association). In FY2015, we donated 10,000 SIND (an accumulated total of approximately 140,000 SGD).
Philippine Wacoal Corp. has always been keen on understanding the needs of women. We believe that wellness is an important aspect in order to be beautiful. All year round, we conduct breast cancer awareness activities in partnership with a non-profit organization, Gift2Life, Inc. This campaign is called, Keep Abreast.
Keep Abreast campaign focuses on breast cancer awareness through seminars or exhibits. We aim to achieve early detection and appropriate treatment, increase breast cancer survival and save lives in the Philippines. In 2013-2014, Keep Abreast was able to tap military camps like naval and army bases nationwide. We were able to share this advocacy as well to our Direct Sales dealers and customers in Davao, Cebu, Iloilo, Bohol Isabela, Cagayan de Oro and Metro Manila. Last October 2015, we participated once again in the Takbo Breast Friends fun run events to help spread awareness. Also on October 2016, we organized an event which was open to public for free so that attendees will get to know more about breast cancer. Together with our partner, Gift2Life, Inc. we will continuously help build communities with knowledge and access to better breast health and help in decreasing deaths from breast cancer among Filipinos.
Wacoal Malaysia's Pink Ribbon Campaign's program includes online Photo Contest on FB, a month-long Fitting Campaign,giveaways of Pink Kit to customs at all counters and also Remama info is also available.
Themed "Got Breast,Join us",the highlight of Wacoal's Pink Ribbon Campaign year 2015 combined force with over 600 cycling enthusiasts in the hope of spreading breast cancer awareness even further and wider. Covering more than 24km, the cycling event, which flagged off and ended at NSTP HQ, passed through prime areas in the Klang Valley; with every cyclist wearing pink T-shirt bearing the "Beat Breast Cancer" message.
In October every year, we decorate shops and counters with Pink Ribbon displays to raise the awareness of our customers toward breast cancer screening, explain about Wacoal's Pink Ribbon activities, and sell Pink Ribbon badges.
We will work not only to announce and raise awareness of breast cancer at shops, but also to disseminate information to a wider audience by placing advertising notifications in women's magazines.


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Patti Oblath, Executive Director
Chante Bernard, Director of Operations & HR
Martha Gonzalez, Subsidized Programs Manager
Judy Laureano, Resource & Referral Manager
Find Child Care
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M Is For...
M is for monkey, moon and match. This alphabet coloring page featuring the letter M is also a great chance to reinforce safety as your child reviews objects and M-words. Turn coloring time into a fun learning moment!
Click to find similar content by grade, subject, or standard.


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UK Law
Get UK Law Questions Answered by Verified Experts
But my understanding is that up to now it has been virtually impossible to get a judge to agree to a charging order if all ccj payments are up to date, but from today judges will agree to a charging order even if no payments have been missed. Is this correct?
Ok .... so nothing has really changed then?
Hello. I am not sure. Please have a look at this page, as the situation does appear to be different since last week.
Yes, but it is saying that these are probably unenforceable:
"It is well known that many District Judges have dealt with re-determination and Charging Order hearings on the basis that it is possible that a Charging Order can be made even though there has not yet been a default in a periodic payment order, thereby obviating enforcement by other means. However, it is arguable that many of these orders are unlawful and unenforceable."
What would be the best defence against a charging order now? That it could affect other creditors in someway?
So, if paying a ccj regularly is no longer enough, what would now be the best defence against someone attempting to put a charging order in place?
So you believe that there is no defence possible?


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Welcome to the TSFC Forum! We enjoy meeting folks interested in Tourette Syndrome and who want to share their experience with the disorder.
I did not know what TS was until I was in my forties. Until then it was my deep dark secret, because I thought I was the only one in the world doing the things I could not help doing.
One day I heard a public service announcement by TSFC read by William Shatner, who was describing ME!!!
I finally learned that it had a name and I was not alone.
It's no longer my deep dark secret, so now I try to help others who are troubled by TS.
Please share your story about what brings you to our online community by introducing yourself in a new posting in this message section.


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