text:
- Draw
- Draw Draw, n.
1. The act of drawing; draught.
[1913 Webster]
2. A lot or chance to be drawn. [1913 Webster]
3. the act of drawing a lot or chance. ``The luck of the draw.'' [PJC]
3. A drawn game or battle, etc; a tied game; a tie. [Colloq.] [1913 Webster +PJC]
4. That part of a bridge which may be raised, swung round, or drawn aside; the movable part of a drawbridge. See the Note under {Drawbridge}. [U.S.] [1913 Webster]
5. The result of drawing, or state of being drawn; specif.: (a) A drawn battle, game, or the like. (b) The spin or twist imparted to a ball, or the like, by a drawing stroke. [Webster 1913 Suppl.]
6. That which is drawn or is subject to drawing. [Webster 1913 Suppl.]
The Collaborative International Dictionary of English. 2000.

subset: commoncrawl


text:
1,500 Google Reviews
The controller for my Masterbuilt smoker was the exact part I needed. Finding it was easy on their site and ordering was quick and easy also.
Cast iron burner
15 x 7-1/8 inch
28091 for production order. same as mcm20502-mcm80901 (this kit only needs one of mcm80901 not two) jade 1205000000
Delta: DBQ42F
Dynasty: DBQ30F DBQ30FL DBQ30FN DBQ30L DBQ30MA DBQ30mad DBQ30N DBQ30PA DBQ30pad DBQ42FL
Dynasty Continued: DBQ42FN DBQ42L DBQ42N DBQ42pa DBQ42pad DBQ54L DBQ54N DBQ55TA
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This part may fit other models. Please contact us if you require additional assistance.
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text:
|2008-07-03, 19:21
|Link #345
Though I'd prefer if my first three volumes didn't become obsolete (meaning they release what Geneon already released as Geneon already released it). I'm happy that it's coming out at all, but I don't want to have to rebuy volumes 1-3.
Also, a Kai license would be nice too. *hopes*
|2008-07-03, 21:28
|Link #347
Turnin' the Tables
Join Date: Feb 2008
Location: Where dimensions collide...
Age: 29
It's not unprecidented that series are entirely redubbed, but they are few and far between. I know if I ruled the world/had exorbitant amounts of disposable income that I would definitely had the series redubbed.
|2008-07-03, 22:49
|Link #348
Join Date: Jun 2008
It's not the voices, really. Aside from Rika's, I can tolerate most of them. And I like being friends with the VA for my favorite character, who everyone seems to agree did a perfect job. It's all the little things.
-Limited Edition that was really nothing special. If you really want to encourage people to buy this, make it worth it. And what the heck was up with that box? Higurashi is a new murder-mystery anime you're trying to promote, so why the heck would you make the box a pink that doesn't match the DVDs, with the main characters looking like sluts? It gives people the wrong idea about the anime, clashes terribly, doesn't exactly encourage the female fans to buy, and I know of at least several parents that refused to pick this up for their kids because they thought it was a hentai. Give us a pencil board or a real poster or a t-shirt or something.
-Descriptions on the backs of the DVDs that were either inaccurate or filled with spoilers. Then add the unshadowing of the opening scene of the first episode and individual episode summaries, and all surprise is just about gone.
-Huge, bright neon subtitles. Doesn't exactly scream horror, and they're annoying. People are just gonna stick with WiND if you make subs like that.
-Not bothering to recolor the scene in episode 1 or 2, where Mion is having a serious crisis during that picnic scene. How the heck does something like that even happen?
-No extras. Even when extras were promised online and on store sites, they were never on any of the DVDs. Trailers are not extras, people.
And that's just to name a few problems I had with the Geneon release. Someone needs to do something. This series has amazing potential, but can Funimation wield it properly?
|2008-07-04, 23:54
|Link #350
Join Date: Mar 2007
You do also realize that the box, though it doesn't cover the murder-mystery aspects of Higurashi, illustrates the "moe" side of the show. I mean, it is a show that's designed with a specific audience in mind: Male Japanese viewers who are into moe, horror and/or mystery shows, in addition to those who've played the games.
While I can agree that there could have been more extras, I kinda like the box design because it's so devilishly misleading. Besides, there's always the insert inside of the box that gives an informative description of the title, and that doesn't mislead. The show wasn't meant to be family-friendly at all, so why do they have to change it?
|2008-07-05, 00:20
|Link #351
Join Date: Jun 2008
I don't know if the technical issues were in the Japanese version, but I do recall hearing they did have the color problem, but had fixed it.
And I don't mean actual kids. Even teenagers sometimes use their parents' credit cards or go to the store with them or ask them to pick something up for them. As fans, we naturally know the series has a moe side and the box shows that, but a parent or new fan would not, and a lot of people aren't into hentai. I hate to say it, but a lot of the Higurashi art can be a bit tasteless. The rather disturbing official pic of the girls in swimwear comes to mind. When you are releasing a new series, you want a box that makes people interested. And it still clashes terribly with the DVDs. Shion is shaded to look like she's not wearing underwear, and she is practically making out with Mion. Then the two little girls wearing the skimpy leather outfits. It's misleading, and what about all the female fans? They should just stick with a different box. That one would be better suited for later or something.
|2008-07-05, 01:32
|Link #352
Join Date: Mar 2007
Doesn't that kinda indicate that the "female audience", as well as people who might be disturbed at looking at those kind of things might not have been included in Geneon's list of target audiences when releasing this show? If someone is offended by looking at girls wearing those kind of outfits, then they probably can't handle seeing the same girls being subjected to horrendous violence.
|2008-07-05, 01:40
|Link #354
Join Date: Mar 2007
Either way, the people that might be offended by seeing the artwork probably weren't the people Geneon intended to cater to. They released this primarily with the hardcore male otaku in mind. It's nice to see females enjoying such a great title, but the show wasn't really designed to cater to them, much in the same way that anime isn't really made with a non-Japanese audience in mind. I see little incentive for them to even care, because it makes little sense for them to change something just because they've offended some people who weren't even part of their target audience to begin with. Besides, is there something inherently wrong with hentai in general? If you're concerned with what other peoples' perception of anime and its viewers, have you considered actually enjoying the hobby instead of being occupied with what others think? You're taking things too seriously.
Anyways, Higurashi has two sides to it: The horror-filled murder-mystery side, and a fetishy, moe-filled side with innuendo mixed in. The box art focuses on the moe element, while the art on the DVD case focuses on the murder-mystery aspect. If I were tasked to market this title, I'd say that the female audience is the least likely to pick this one up, because both aspects of the show were mostly designed with a male audience in mind. I mean, I can't really imagine trying to market a horror-style title while trying to be sensitive to the female audience, and neither can I imagine successfully marketing a title with fetishy moe elements that contains some innuendo, all the while trying to be sensitive to the female audience. With this in mind, how exactly is their marketing division supposed to be sensitive to the female audience when trying to market a title that combines those two elements?
Last edited by grgspunk; 2008-07-05 at 02:33.
|2008-07-05, 03:06
|Link #355
Rena X Keiichi FOREVER!
Join Date: Jan 2008
|2008-07-05, 16:04
|Link #356
Join Date: Jun 2008
Exactly, Dreamie.^^ And when you're dealing with a series like Higurashi, your job is to cater to everyone who might like it. To long-time fans, it might add to the fun to see new people buy it thinking it's something else, but how would you feel if you thought you were buying one thing and ended up with something completely different? Higurashi's not for everyone, and I reckon a lot of people would be ticked off. And like I said, the box horribly clashes with the DVDs thenselves and gives nothing to the many female fans. I think they should release it in a darker box. Come on, Funimation, don't let us down!
|2008-07-06, 22:56
|Link #358
Join Date: Aug 2007
Location: NYC, NY
Age: 39
|2008-07-07, 21:09
|Link #360
Senior Member
Join Date: Apr 2006
Spoiler for plot spoiler regarding episode 1-4:
Last edited by Skyfall; 2008-07-11 at 16:04.
|Thread Tools


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Rent space at ACAD
Consider booking our facilities for your next meeting or event – we've got options to suit everyone.
Located minutes from Calgary's core, with convenient parking and C-Train access, ACAD is the perfect location for your next event, meeting or reception.
We have a range of available facilities, including fully equipped classrooms, lecture theatres, collaborative spaces, studios, and large reception areas that are functional, affordable and adaptable.
We provide a seamless, stress-free experience and ensure you have everything you need for your time on campus.
Please fill out the form below to get us started on coordinating your space requirements.


text:
Grounds Staff
- Recruiter
- Haileybury
- Location
- Hertford Heath, Hertford
- Salary
- Competitive
- Posted
- 10 Jan 2017
- Closes
- 03 Feb 2017
- Ref
- Full Time - 38.75 hours per week
A committed and capable individual is required to work within the Grounds Department in this outstanding independent boarding school. The primary responsibilities of the role are to undertake the full range of Grounds activities required in order to maintain and develop the Haileybury site. The successful candidate will have: significant experience in the field of Groundsmanship; experience in maintaining high quality sports pitches, preferably within an educational environment and be qualified to at least NVQ level 2 in a related subject. Having PA1/PA2/PA6 Certificates would be an advantage. In addition, they will have good communication skills and have the ability to work effectively as part of a team.
For an application pack, please visit www.haileybury.com/my-haileybury/careers-haileybury or, alternatively, please contact Human Resources, on 01992 706379.
For an informal discussion, please contact Mr Eamonn Murphy, Grounds Manager, on 01992 706435.


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well im signing of for the day. my computers dieing and i got to get back to school see ya later.
Atra esterní ono thelduin. Mor'ranr lífa unin hjarta onr. Un du evarínya ono varda.
May good fortune rule over you. Peace live in your heart. And the stars watch over you.


text:
Went for dinner house made chips are great. Step above bar atmosphere. Food is good. Decent wine list.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.
Went for dinner house made chips are great. Step above bar atmosphere. Food is good. Decent wine list.
My husband and I stopped here for an early dinner on a Friday. Our server was really nice. We enjoyed some of the happy hour specials (really cheap beer - price not quality) and liked our food. The food was just alright though, not great. I got the fish and chips and he got the French dip sandwich. The ambiance is very casual but nice enough. Because it was happy hour, we got quite a lot of food for not much money. Our only complaint was one server (I think another reviewer even mentions her too) who literally would not stop bothering us. She was not OUR server, she just seemed to roam the restaurant bothering the customers. Weird. If they would get rid of her (or just make her stop), then I would have given it a higher rating.
Our group of six enjoyed the meal and the live entertainment. The drinks were generous and the prices were very fair.
Okay, first part. A cute little server comes by and asks how we are doing. We are near the end of the meal and my teenage daughter is a slow eater. The server asks if she is done and my daughter tells her no. No joke, not even 30 seconds go by and the same server comes by and asks my daughter, "Are you done with that?" My daughter was so polite, but looked at my wife and I like she just got sucked into the Twilight Zone.
The food is average. It hit the spot after a long day of ziplining and lake viewing. The pizza crust seemed a little store bought, pre frozen, not handmade. The salads were average, nothing to shout from the mountain tops. The fish and chips were the saving grace. Fried fish was flakey, decent portion, and the malt vinegar aioli was spot on.
Instead of bread, they bring out fresh potato chips. Look out cholesterol here I come. But, I lost the will power, and asked for a second serving.
We stopped in for dinner. The restaurant was dark and they had candles lit in the fireplace, my wife thought it was romantic. I ordered a pizza called the Hangover, it was different and very delicious (chorizo, jalepenos and pineapple). My wife had the Calamari appetizer and some of my pizza. Staff was friendly.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


text:
- Details
- Written by 1st Admin
Category: Company Profile
Published on 14 August 2014
Customer Charter
While striving on our vision to make RAMDAC HIGH TECH SDN. BHD. as an excellent company with ICT, Construction, Building Maintenance and Trading as its platform, we promise to serve our customers' rights as follows:
To Customer Especially To Youth
- To provide learning facilities and ICT knowledge in order to help Malaysian youth to become ICT literate toward globalization.
- To give satisfying services to customer before and after sales.
To Country
- To open the mind of youths about how important it is to become ICT literates to fulfill country needs.
- To provide training, research and consultancy services in order to improve the level of knowledge development.


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Concept mapping, mind mapping and argument mapping: what are the differences and do they matter?
In recent years, academics and educators have begun to use software mapping tools for a number of education-related purposes. Typically, the tools are used to help impart critical and analytical skills to students, to enable students to see relationships between concepts, and also as a method of assessment. The common feature of all these tools is the use of diagrammatic relationships of various kinds in preference to written or verbal descriptions. Pictures and structured diagrams are thought to be more comprehensible than just words, and a clearer way to illustrate understanding of complex topics. Variants of these tools are available under different names: "concept mapping", "mind mapping" and "argument mapping". Sometimes these terms are used synonymously. However, as this paper will demonstrate, there are clear differences in each of these mapping tools. This paper offers an outline of the various types of tool available and their advantages and disadvantages. It argues that the choice of mapping tool largely depends on the purpose or aim for which the tool is used and that the tools may well be converging to offer educators as yet unrealised and potentially complementary functions.


text:
Hurry Hurry!
Kate Spade is having a 75% off wedding items sale! I can't believe my eyes. I'll take one of everything!
Make sure you hurry over- the sale ends on 7/17!
Here are some of our favorite sale items!
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Opening Night Spray Necklace – $89
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Vail Dress- $169
Photo Credit: All photos from KateSpade.com
Happy Shopping!!!


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Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes
Cellular and molecular mechanisms
The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of intracellular Ca2+ in adult human astrocytes. Ca2+-sensitive spectrofluorometry was carried out to determine mobilization of intracellular Ca2+ following adenosine triphosphate (ATP) or 3′-O-(4-benzoyl)benzoyl-ATP (Bz-ATP) stimulation of adult human astrocytes. In some experiments pharmacological modulation of Ca2+ pathways was applied to help elucidate mechanisms of Ca2+ signaling. RT-PCR was also performed to confirm human astrocyte expression of specific purinoceptors which were indicated from imaging studies.
The endogenous P2 receptor agonist ATP (at 100 μM or 1 mM) applied in physiological saline solution (PSS) evoked a rapid increase of [Ca2+]i to a peak amplitude with the decay phase of response exhibiting two components. The two phases of decay consisted of an initial rapid component which was followed by a secondary slower component. In the presence of Ca2+-free solution, the secondary phase of decay was absent indicating this prolonged component was due to influx of Ca2+. This prolonged phase of decay was also attenuated with the store-operated channel (SOC) inhibitor gadolinium (at 2 μM) added to standard PSS, suggesting this component was mediated by SOC activation. These results are consistent with ATP activation of P2Y receptor (P2YR) in adult human astrocytes leading to respective rapid [Ca2+]i mobilization from intracellular stores followed by Ca2+ entry through SOC. An agonist for P2X7 receptor (P2X7R), BzATP induced a very different response compared with ATP whereby BzATP (at 300 μM) elicited a slowly rising increase in [Ca2+]i to a plateau level which was sustained in duration. The BzATP-induced increase in [Ca2+]i was not enhanced with lipopolysaccharide pre-treatment of cells as previously found for P2X7R mediated response in human microglia. RT-PCR analysis showed that adult human astrocytes
These results suggest that activation of metabotropic P2YR (P2Y1R and/or P2Y2R) and ionotropic P2X7R could mediate purinergic responses in adult human astrocytes.
Astrocytes respond to a variety of physiological and pathological stimuli with an increase in intracellular Ca2+ concentration ([Ca2+]i), often referred to as "Ca2+ signaling" or "Ca2+ excitability"
Activation of purinergic receptors alters Ca2+-dependent pathways and intracellular levels of Ca2+ which in turn determine cellular functional responses to endogenous ligand, ATP. For example, ATP stimulation of P2YR not only mobilizes [Ca2+]i from stores but also leads to influx of Ca2+ through store-operated channels (SOC) subsequent to store depletion. An alternative pathway for entry of Ca2+ from extracellular medium is provided by activation of family members of P2XR ionotropic channels. Overall, a diversity of astrocyte functional responses such as cellular growth and proliferation, cytokine production and regulation of cerebral blood flow can depend on the characteristics of Ca2+ signaling in cells
At present, few studies have addressed the expression and properties of Ca2+ signaling in adult human astrocytes compared with work on rodent astrocytes. Furthermore, the majority of studies on human astrocytes have involved use of fetal cells. Specific properties and activity of astrocytes could differ depending on their species as well as ages. For example, human astrocytes are substantially larger, more complex and propagate Ca2+ signals significantly faster than their rodent counterparts
The main purpose of this study was to characterize Ca2+ signaling pathways in adult human astrocytes following activation of purinergic receptors. Calcium-sensitive fluorescence spectroscopy has been used to determine P2YR and P2XR contributions to [Ca2+]i mobilization in stimulated cells. In addition, reverse transcription polymerase chain reaction (RT-PCR) has indicated the expression of P2Y1R, P2Y2R and P2X7R in the adult human cells. To our knowledge, this work is the first report describing changes in intracellular Ca2+ mobilization associated with activation of purinergic receptors in primary culture of adult human astrocytes.
Chemicals and reagents
ATP, 3′-O-(4-benzoyl)benzoyl-ATP (BzATP), lipopolysaccharide (LPS), gadolinium and dimethyl sulfoxide (DMSO) were obtained from Sigma-Aldrich (St. Louis, MO). ATP and BzATP were dissolved in PBS solution. Fura-2/AM (F-1221) was purchased from Invitrogen Canada (Burlington, ON) and dissolved in DMSO.
Cell culture
Adult human astrocytes were obtained from epileptic patients undergoing temporal lobe surgery with consents of all patients. Normal brain tissues overlying the epileptic foci were obtained from a standard elective surgical procedure where, in order to remove an epileptic focus, the surgeon first removed normal brain tissue which lies superficial to the previously defined epileptic focus. The epileptic patients were a 27 year-old male, 31 year-old female, 36 year-old female and 41 year-old male. Every brain sample arrived at our laboratory within 24 h after surgery and was immediately used for astrocyte isolation. The use of human brain materials was approved by the Clinical Research Ethics Board for Human Subjects of the University of British Columbia.
Astrocytes were isolated as described previously
Calcium spectrofluorometry
A previous procedure established for measurement of intracellular Ca2+
ATP-induced responses exhibited fast and slow components of decay. The time course of the rapid initial decay was measured at a point at half-amplitude of peak response. The time course of the secondary slower phase of decay was measured at half-amplitude of this component. The height of the prolonged phase was determined as the point of intersection of the component with time at peak response. ATP response in Ca2+-free PSS or in standard Ca2+ solution containing Gd3+ showed single phase decays from a peak value with time courses determined at half-amplitude values of peak. BzATP-induced response consisted of a single phase of a slowly developing increase to a peak level with amplitude of fluorescent ratio used as a measure of response.
Primary human astrocytes were seeded onto 6-well plates (4 × 105 cells per well in 2 ml total volume) in DMEM/F12 containing 10% fetal bovine serum. After 48 h, total RNA was isolated using a commercially available kit according to the manufacturer's instructions for adherent cells (Aurum™ Total RNA Mini Kit, Bio-Rad Laboratories, Inc., Hercules, CA). RNA concentration was measured using a spectrophotometer and purity ensured by 260/280 nm ratio of >1.95 for all samples. cDNA was reverse-transcribed using the qScript™ cDNA Synthesis Kit from Quanta Biosciences (Gaithersburg, MD). PCR amplification of cDNA was performed as described previously
Data are presented as means ± standard error of mean (SEM). Statistical significance was determined using one-way analysis of variance (ANOVA) followed by Student-Newman-Keuls multiple comparison test. P < 0.05 was considered statistically significant.
ATP-induced changes in [Ca2+]i
We first confirmed that in excess of 99% cells in astrocyte culture were positive for GFAP under our culture conditions (see Methods). A representative image of cultured cells is presented in Figure
Figure 1
Immunocytochemistry of cultured adult human astrocytes
Immunocytochemistry of cultured adult human astrocytes. Representative image of purified culture of adult human astrocytes stained with GFAP (red). Cellular nuclei were counterstained with Hoechst 33258 (blue).
Calcium-dependent spectrofluorescence was used to examine effects of ATP on [Ca2+]i in adult human astrocytes. The experiments generally employed 1 mM of ATP (application time of 200 s); this level of ATP is insufficient to activate the P2X7 subtype ionotropic receptor in human microglia
Figure 2
Intracellular calcium responses to ATP in adult human astrocytes
Intracellular calcium responses to ATP in adult human astrocytes. (A) Representative change in intracellular Ca2+ ([Ca2+]i) (response collated from 20 cells) to ATP (applied at 1 mM) in Ca2+-containing physiological saline solution (PSS). The change in [Ca2+]i exhibited a biphasic time course with time components of 18.5 s and 49 s for the fast and slow phases of decay, respectively. The arrow indicates the inflection point between the rapid and prolonged components of the decay phase of response. (B) Typical mobilization of [Ca2+]i (response collated from 9 cells) induced by a lower level of ATP (applied at 100 μM) in standard PSS. A biphasic change in [Ca2+]i was observed (arrow indicated inflection point) with respective rapid and slow component decay times of 17.8 s and 58.7 s. (C) Representative [Ca2+]i mobilization (response collated from 22 cells) to 1 mM ATP applied in Ca2+-free PSS. A single component of decay of response was observed with a time course of 23.2 s. (D) Representative change in [Ca2+]i (response collated from 20 cells) to 1 mM ATP in the presence of gadolinium (Gd3+ at 2 μM pretreatment for 200 s) in standard PSS. A single monophasic time course of decay for [Ca2+]i was observed with a time course of 25.6 s. All cells shown in this figure were obtained and cultured from a single human surgical case.
Physiological and pharmacological protocols were used to examine modulation of Ca2+ entry into adult human astrocytes using application of 1 mM ATP. In one set of experiments, extracellular Ca2+ was replaced with Ca2+-free PSS to prevent influx of Ca2+ as a contributing mechanism for changes in [Ca2+]i. A typical astrocytic response induced by ATP in Ca2+-free PSS is presented in Figure
The prolonged phase of [Ca2+]i elicited by ATP in standard PSS (Figure
BzATP-induced changes in [Ca2+]i
Figure 3
Intracellular calcium responses to BzATP in adult human astrocytes
Intracellular calcium responses to BzATP in adult human astrocytes. (A) Representative change in intracellular Ca2+ ([Ca2+]i) (response collated from 21 cells) to BzATP (applied at 300 μM). The amplitude of response, expressed as a ratio of fluorescent intensity 340/380, was 0.23. (B) Representative change in [Ca2+]i (response collated from 25 cells) to BzATP in the presence of lipopolysaccharide (LPS at 100 ng/ml, pretreatment for 16 h). The amplitude of response (F340/380) was 0.26 from baseline to plateau level. Data shown in this figure was recorded from cells obtained and cultured from one surgical case.
Previous work has demonstrated LPS priming of BzATP responses, measured as amplitudes of fluorescent ratio, in microglia which was attributed to inflammatory enhancement in numbers of P2X7R
Expression of P2Y1R, P2Y2R and P2X7R in adult human astrocytes
The results from imaging experiments for changes in [Ca2+]i suggest functional expression of metabotropic and ionotropic P2R subtypes in cultured adult human astrocytes. We therefore carried out RT-PCR to examine expression for particular P2R, including P2Y1R, P2Y2R and P2X7R, which have previously been reported to mediate Ca2+ response
Figure 4
Expression of P2X and P2Y purinoceptors in adult human astrocytes
Expression of P2X and P2Y purinoceptors in adult human astrocytes. RT-PCR assay with 40 amplification cycles detected bands of expected size for P2Y1R (A, 647 bp), P2Y2R (B, 638 bp) and P2X7R (C, 465 bp) in total RNA extracted from culture of adult human astrocytes. Photos are representative of results obtained using cells from 3 independent surgical cases.
To our knowledge, this is the first study that demonstrates intracellular Ca2+ mobilization following activation of purinergic receptors in cultures of primary adult human astrocytes. We report ATP induction of intracellular Ca2+ mobilization mediated by depletion of intracellular stores consistent with activation of metabotropic P2YR in adult human astrocytes. This component of [Ca2+]i change is followed by a subsequent influx of Ca2+ through SOC. RT-PCR analysis demonstrated the expression of specific subtype metabotropic P2Y1R and P2Y2R in addition to ionotropic P2X7R. Interestingly, this expression pattern of P2 purinoceptor in adult human astrocytes is consistent with observations made in fetal human
ATP stimulation of adult human astrocytes mobilized intracellular Ca2+ with a response characterized by two components of decay. The initial rapid transient component following peak response is consistent with activation of metabotropic P2YR and mediated by Ca2+ release from ER stores independent of extracellular Ca2+
Ca2+ spectrofluorometry showed that application of BzATP elicited a gradual and sustained increase in [Ca2+]i in adult human astrocytes. This finding suggests influx of Ca2+ through the nonselective cationic channel coupled to activation of P2X7R
Purinergic agonists and antagonists are notorious for non-specific activity
We found that LPS priming of human astrocytes (100 ng/ml for 16 h) had no significant effect to alter amplitude of BzATP-induced responses compared with controls (no LPS pretreatment). Interestingly, this result is in contrast to previous findings on fetal human microglia which demonstrated that exposure of cells to LPS (100 ng/ml for 2 h) significantly enhanced the amplitude of BzATP-evoked [Ca2+]i
Our study has presented novel findings concerning expression and activation of specific purinergic Ca2+ signaling pathways in cultured adult human astrocytes. Metabotropic P2YR and ionotropic P2XR are putative mediators of purinergic responses in the cells. Future studies using adult human astrocytes are warranted to characterize the specific roles of the purinergic receptors in mediating cellular responses. Such work will enable clarification of downstream Ca2+-dependent and independent signaling pathways. P2X7R expression and function should be confirmed in these cells followed by examination of roles of the receptor in mediating astrocytic responses in pathological microenvironments in human brain.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
SH, YFW and JGM participated in the design of the study. SH and YFW carried out all experiments, collected the data and performed the statistical analysis. JPL and AK performed the RT-PCR analysis. HCB participated in calcium spectrofluorometry. SH, YFW and JGM interpreted the data. SH and JGM wrote the manuscript. JGM, HCB, AK and PLM revised the manuscript. All authors read and approved the final manuscript.
This research was supported by the Pacific Alzheimer Research Foundation (SH, PLM and JGM), Grant-in-Aid for Scientific Research #24591721 (SH) and the Jack Brown and Family Alzheimer's Disease Research Foundation (JPL and AK).
ATP: a ubiquitous gliotransmitter integrating neuron-glial networks
P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy
Purinergic mediated changes in Ca2+ mobilization and functional responses in microglia: effects of low levels of ATP
Trophic functions of nucleotides in the central nervous system
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation
Heterogeneity of astrocytic form and function
Isolation and culture of human astrocytes
Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells
STAT3 inhibitors attenuate interferon-gamma-induced neurotoxicity and inflammatory molecule production by human astrocytes
Differential activation of subtype purinergic receptors modulates Ca(2+) mobilization and COX-2 in human microglia
Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain
ATP stimulates chemokine production via a store-operated calcium entry pathway in C6 glioma cells
Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus
Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells
Extracellular nucleotides differentially regulate interleukin-1beta signaling in primary human astrocytes: implications for inflammatory gene expression
Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells
Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B
Pharmacological profile of store-operated channels in cerebral arteriolar smooth muscle cells
The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes
Coexpression of several types of metabotropic nucleotide receptors in single cerebellar astrocytes
Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons
Molecular physiology of P2X receptors
Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model
Pharmacological characterization of recombinant human and rat P2X receptor subtypes
Modeling P2Y receptor-Ca2+ response coupling in taste cells
P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes
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by Tiffany
(Birmingham, Al)
I have made so many mistakes in my 28 years on this Earth. Lord I just pray for your forgiveness, strength, and wisdom. Lord I have faced so many heartbreaking tragedies and my heart aches for healing. Please help to forgive myself and others as You forgive us. Please help me to rebuild my life, my heart, my faith, and to make amends for all those who have been affected by my actions. Please fill my heart with the joy, strength, and happiness I long for. Please help me help others in need and show them your grace.
Join in and write your own page! It's easy to do. How? Simply click here to return to Prayers for Strength.
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GenVec Inc (GNVC) Short Interest Update
GenVec Inc (NASDAQ:GNVC) was the recipient of a large decline in short interest in the month of May. As of May 15th, there was short interest totalling 244,582 shares, a decline of 2.2% from the April 28th total of 250,068 shares. Based on an average trading volume of 35,385 shares, the short-interest ratio is presently 6.9 days.
Several institutional investors have recently added to or reduced their stakes in GNVC. Perceptive Advisors LLC acquired a new position in GenVec during the fourth quarter valued at about $180,000. Geode Capital Management LLC increased its position in GenVec by 10.8% in the first quarter. Geode Capital Management LLC now owns 17,218 shares of the biopharmaceutical company's stock valued at $104,000 after buying an additional 1,675 shares during the last quarter. Finally, Vanguard Group Inc. increased its position in GenVec by 37.1% in the first quarter. Vanguard Group Inc. now owns 25,745 shares of the biopharmaceutical company's stock valued at $156,000 after buying an additional 6,973 shares during the last quarter.
Shares of GenVec (NASDAQ GNVC) opened at 6.59 on Friday. The firm's market cap is $14.98 million. GenVec has a 12-month low of $0.27 and a 12-month high of $10.44. The firm's 50-day moving average is $6.54 and its 200-day moving average is $5.35.
TRADEMARK VIOLATION WARNING: "GenVec Inc (GNVC) Short Interest Update" was originally reported by American Banking News and is the property of of American Banking News. If you are reading this story on another site, it was copied illegally and republished in violation of U.S. & international copyright & trademark laws. The correct version of this story can be viewed at https://www.americanbankingnews.com/2017/06/04/genvec-inc-gnvc-short-interest-update.html.
About GenVec
GenVec, Inc (GenVec) is a clinical-stage biopharmaceutical company, engaged in the development of therapeutics and vaccines. The Company designs, tests and manufactures adenoviral-based product candidates. The Company's development programs address therapeutic areas, such as hearing loss and balance disorders, as well as vaccines against infectious diseases, including respiratory syncytial virus (RSV), herpes simplex virus (HSV), Enterovirus D68 (EV-D68) and malaria.
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Enable Auto-complete in Mozilla® Firefox
The following explains features and tips to enable auto-complete feature in Mozilla Firefox:
- Importance of Auto-complete in Firefox
- Ways to Auto-fill Forms
- Tips to Enable Auto-complete
Importance of Auto-complete in FirefoxAuto complete is one of the most important features in Firefox. This remembers whatever you type in the address bar. If the user just needs only one website, then he just needs to adjust the settings in the Auto complete feature. This helps the user to complete forms with the help of suggestions provided. There is no need to complete a full search keyword to open a form.
Tips to Enable Auto-completeTo enable auto-complete option in Firefox, first you need to open Firefox web browser. Go to 'Tools' menu and select 'Options' followed by 'Privacy'. You need to select 'Remember History' option followed by 'Firefox will'. This will enable auto-complete feature in Firefox.
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Thinking Positive About the Future Panel Event
CIP Berkshire
Friday, June 14, 2013 from 2:00 PM to 4:30 PM (EDT)
Event Details
Insight Into College, Employment and Independence for Young Adults on the Autism Spectrum and with Learning Differences
Parents and professionals are invited to join us for an informative event designed to provide a comprehensive overview of postsecondary options for young adults with Asperger's, High Functioning Autism, ADHD, NLD and other Learning Differences.
Thinking Positive About the Future will include presentations by several guest speakers who work with the ASD and LD community; offering advice on the key stages of transition to adulthood including: letting go, adjusting to college, finding success in the workplace, and achieving independence.
Presentations By:
Michael P. McManmon - Dr. McManmon is the founder of the College Internship Program (CIP), which serves college-aged students with learning differences and Asperger's Syndrome in six centers across the US. He is a blog author for Psychology Today and his book, "Made for Good Purpose" has been published by Jessica Kingsley Publishers. During his 39 years of experience with students with Learning Differences and Asperger's Syndrome, Dr. McManmon has worked on Curriculum Development, Staff Training, Program Evaluation, and Administering Community Based Programming.
Nathan Doty - Dr. Nathan Doty is currently an Instructor in Psychology in the Learning and Emotional Assessment Program (LEAP) within the Department of Psychiatry at the Massachusetts General Hospital/Harvard Medical School. Dr. Doty specializes in neuropsychological assessment of children and adolescents with developmental, neurological, emotional, and behavioral concerns. He has a broad foundation of training in child, adolescent, and adult assessment.
Barbara Bissonnette - Barbara Bissonnette is a certified coach and the Principal of Forward Motion Coaching. She specializes in career development coaching and workplace advocacy for individuals with Asperger's Syndrome and Nonverbal Learning Disorder. She is the author of the Asperger's Syndrome Workplace Survival Guide: A Neurotypical's Secrets for Success, and The Complete Guide to Getting a Job for People with Asperger's Syndrome, which is available from Jessica Kingsley Publishers and other book sellers.
Nataliya Poto - Nataliya is an Adjunct Faculty at the Psychology Department, UMASS/Lowell and AANE's Adult Services Staff. Her applied research involvement included evaluation of employment support programs and music interventions for adolescents on the autism spectrum. Currently, she directs the LifeMAP Adult Coaching Program and conducts its research evaluation in collaboration with Professor Ashleigh Hillier, Ph.D. from UMASS/Lowell. Since 2008 the LifeMAP program has served more than 300 adults on the autism spectrum, currently there are 97 teen and adult clients in the program served by 46 lifeskills coaches.
Peter F. Love - Dr. Love is an educator and professional learning disabilities coach with over thirty years of experience supporting students with disabilities and other learning challenges. He is the Founder of Peter Love Educational Consulting in East Hampton, Connecticut where he provides educational consulting, individualized educational and achievement testing and evaluation and personal coaching services. Dr. Love lectures nation-wide on issues of helping to prepare and support high school students and young adults who are planning a post-secondary education and currently serves as President of the Connecticut Association for Higher Education (AHEAD).
- (2:00pm - 2:30pm) Registration, mingling and refreshments
- (2:30pm - 4:00pm) Panel presentations
- (4:00pm - 4:30pm) Open Q&A and mingling
When & Where
Boston Public Library, Rabb Lecture Hall
700 Boylston Street
Friday, June 14, 2013 from 2:00 PM to 4:30 PM (EDT)
Add to my calendar


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BE TV provides daily student programming for the Eustace Community. BE TV creates feature stories throughout the school year on special events. The members of the BE TV Club also assist to create documentaries related to the Bishop Eustace Community.This web page will be utilized to show the current news broadcasts each morning at approximately 8:20 am and you will be able to see archived shows at the link below.
All BETV broadcasts are viewable on the BETV channel on Schooltube.com.
Bishop Eustace Preparatory School
5552 Route 70, Pennsauken, NJ 08109-4798
Phone: 856.662.2160


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The power to instantly understand a person's past. Sub-power of Past Manipulation. Technique of Retrocognition. Not be confused with Psychometry.
The user can instantly read and understand a person's history just by looking at or engaging in conversation with them. They will learn where they've been, what they've done in the past, and what lead up to them being with the user at that given point.
- Cannot see a person's future or what they're planning to do right now.
- May be limited on how far in the past they can see.
Known Users
- Terumi Yuuki (BlazBlue)
- Azrael (Discworld)
- Neinhart (Fairy Tail)
- Kahn (Gold Digger)
- Yulia Jue (Tales of the Abyss); via the Score
- Fake Shiki (TYPE-MOON)
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"Just One Word… Elastic" – Cisco's Elastic CoreSP360: Service Provider
If you saw the title of the blog and thought, The Graduate, pat yourself on the back! Mr. McGuire: "I just want to say one word to you. Just oneRead More
Faster, Bigger, Stronger, and Smarter: The Next Generation Internet Needs the Cisco Elastic CoreExecutive Platform
In a blog post last week, Cisco cited its recent landmark 100 Gbps IPoDWDM trial with BT, which demonstrates ways to create a Next-Generation Internet, one that can handle aRead More
100G IPoDWDM: Prepping the Core for a Million Video Minutes (per second!)SP360: Service Provider
"Video changes everything". We laugh at silly cat movies. We learn to dance Gangnam style. We cheer for the underdog in an obscure sport (or perhaps even the Spice GirlsRead More
Greece Ready for 100G InternetSP360: Service Provider
One of the most interesting aspects of the Cisco Visual Networking Index is how the explosion of Internet traffic is taking place everywhere. We've talked before about how countries suchRead More
Upgrade to 100G/400G/1T Without Upgrading the Fiber InfrastructureSP360: Service Provider
We talked before about how over 150 customers from 50 different network operators and enterprises met last month at Cisco's campus in Richardson, Texas, to attend the Spring 2012 PacketRead More
Cisco Helps Iceland's Farice Play a Key Role in Green Cloud ComputingSP360: Service Provider
One of the topics we covered this week at the Cisco Packet Optical Networking Conference was cloud computing. A benefit of cloud computing is that the physical infrastructure – theRead More


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BBC Sport - Andy Murray: John McEnroe among contenders to be Scot's coach
Could McEnroe be Murray's new coach?
- From the section Tennis
Andy Murray says seven-time Grand Slam singles champion John McEnroe is among the contenders to be his next coach.
Murray split from Ivan Lendl, formerly a great rival of McEnroe, in March after a two-year partnership that saw him win the US Open,Wimbledon and an Olympic gold medal.
The Scot would like to have his next coach in place in time for the French Open, which starts on 25 May, but is willing to wait longer.
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India will travel to Australia tonight (November 21) to play four Tests and a One Day International tri-series involving the hosts and England.
Revised Schedule is here (Test fixtures changed on December 1 after the tragic death of Phil Hughes)
The opening game of the tour is from November 24 (Monday) when India face Cricket Australia XI in a two-day warm-up game ahead of the Test series.
Here is the full tour schedule, times and where you can watch on TV
All matches barring warm-up games, Live on Star Sports TV in India
Warm-up matches
- November 24-25 - India Vs Cricket Australia XI (Adelaide) 5.30 AM IST
- November 28-29 - India Vs Cricket Australia Invitational XI (Adelaide) 5.30 AM IST - Cancelled
Test series
- December 4-8 - 1st Test - Brisbane (5.30 AM IST) - Postponed due to Phil Hughes' death
- December 12-16 - 2nd Test - Adelaide (5.30 AM IST)
- December 26-30 - 3rd Test - Melbourne (5 AM IST)
- January 3-7, 2015 - 4th Test - Sydney (5 AM IST)
ODI Tri-series (India, Australia, England)
Practice Match
- January 12 - India Vs England XI - Sydney (4.30 AM IST)
- January 16 - India Vs Australia - Melbourne (8.50 AM IST)
- January 20 - India Vs England - Brisbane (8.50 AM IST)
- January 26 - India Vs Australia - Sydney (8.50 AM IST)
- January 30 - India Vs England - Perth (8.50 AM IST)
Note: The Tri-series final is on February 1 (8.50 AM IST) in Perth
India Test Squad
- MS Dhoni (captain and wicketkeeper), Virat Kohli, Shikhar Dhawan, Murali Vijay, KL Rahul, Cheteshwar Pujara, Ajinkya Rahane, Rohit Sharma, Suresh Raina, Wriddhiman Saha (wicketkeeper), Naman Ojha (wicketkeeper), R Ashwin, Karn Sharma, Ravindra Jadeja, Bhuvneshwar Kumar, Mohammed Shami, Ishant Sharma, Umesh Yadav, Varun Aaron.
Note: Virat Kohli will captain India in the first Test. MS Dhoni is ruled out due to an injury.
OneIndia News


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It's more the feeling than a specific event I remember. I was 21, moving 'up the ranks' in ministry. There were so many things I hadn't done, so many things I wanted to do, so many things I dreamed of doing. My whole life seemed to teeter on the edge of excitement and inexperience. Every week it was something new. Preaching to adults. Performing at a youth convention. Speaking to complete strangers about deeply held convictions. Reading a book that immediately impacted my life. At the heart of it all, deeply believing that I was impenetrable, unbreakable. That I could face the tsunami and wade through it.
Now we all romanticize our memories. It's how our brain works. Neurologists tell us we don't truly remember events as they happened (except for the traumatic ones), but rather, we remember the memories of those events. Over time, we colour them with different emotions. (E.g. fondly remembering past relationships, but not remembering the fights and arguments) But in this case, it's not an event or relationship I'm romanticizing, but my mindset, the attitude with which dominated my thinking.
I was fearless.
Now there are some things my older and wiser self would like to tell my younger, zealous self. For example, I would remind him that people were not objects or goals, and that handing out pamphlets did not mean I was spreading God's love. I would tell him not to put women on such a pedestal, and ironically, remind him not to expect perfection from the woman he was with. I would tell him that friends were precious and should be treasured, that the finish line was not as important as the race. But the one thing I wouldn't tell him, wouldn't have to tell him, would be to take risks. To go for it. To not let fear stand in the way.
I stare at the keyboard for a minute and stand up. A heat wave has rolled through the city, and I move to my balcony, where the sun smolders along the creaky old wood. Sweat begins to roll down my face, and I look at the coffee in my hand with a sigh. Dedication has its price. The trees and bushes wave lazily a few feet away, and the smell of moistened mud and concrete rises up in the soft breeze, compliments of an afternoon thunderstorm.
I can't remember when I stopped taking chances. As life began to twist and turn, at times offering more pain and disappointment than encouragement, I stepped back from the edge. For some people, one event, one bad happening, is enough to make them turn the engine off. But for most of us, I think, it's a number of things. And over time, they wear us down.
A dog barks in the distance. Down below me, the big orange tom cat who seems to rule this side of the building lazily turns his head and than sprawls out along the damp grass. It's taken me a while to realize it, to realize just how much fear plays a part in my life. I've always been interested in many things, an 'idea guy', but over the past ten years I've become less and less of a do-er. It's become easier and easier to talk myself out of any new idea. Sometimes the reasons are rational and right, but even then, the longer I let certain fears rule my existence, the less I participate in my life. The less I dream. The less I hope.
I sip my coffee, enjoying the breeze that seems to have picked up, envious of the careless manner of the cat stretched out below me. I'll be honest, I'm afraid of becoming involved in a bad relationship again. And I know it affects the way I approach women, with wariness and cynicism that is ready to propel me backwards to safety. This fear, this cautious approach, has not helped in my writing either. After a couple of hard experiences in the industry, I've found it difficult to push forward. This past year was my first time on a plane by myself. I want to travel more, but I find myself holding back.
What is it that these fears have become such a part of me? When did I decide that this was all that life was, that I'd gone as far as I could go?
Studies show that the most consistent trait in successful people is perseverance. People who are willing to meet their fears head on.
To be fearless.
I take a sip of coffee and head back inside to the cool of my air conditioned apartment. This next year, I will not return to my comfortable position back at the high school. I do not know what I'll be doing, or where I will be. And it scares me.
But what scares me more is that if I don't try to pursue my dreams, that if I allow my fears to win, that if I stay in the known and comfortable, I will always look back to the time when I "was alive." That I'll spend my time remembering "the glory days."
But the glory days are now, no matter how old you are.
For all of us.
We all have fears. We have all suffered heartache and setback and disappointment. It's a part of life. But I think that too many of us let our fears, our hurts and difficulties in the past, dictate our future. Today I am wiping that slate clean, and whatever fears I have, I choose to face them.
Death comes to us all, but what a tragedy when it comes before we die.
May God grant us the strength to identify the things we fear the most, and face them with a courage and decisiveness only He can give. And may we always remember that there is One who believes in us, who will never leave us or forsake us, no matter what fear we face.


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August 9, 2016
Freshman and transfer student orientation sessions for Northwestern Oklahoma State University are just around the corner. Northwestern-Alva also has several welcome-back activities planned for students.
Freshman Orientation activities will take place from 8:30 a.m. to noon on Saturday, Aug. 20, on the Alva campus. Registration begins at 8 a.m. in Herod Hall. The session is required for all freshmen.
Transfer Student Orientation for the Alva campus will take place from 1 to 3 p.m. on Saturday, Aug. 20, in the Education Center, room 109.
Transfer Student Orientation for Woodward and Enid campuses will take place on Friday, Aug. 19, from noon to 1 p.m. Woodward campus orientation will take place in the Phillips conference room, while the Enid campus orientation will take place in the Enid commons area.
After the traditional freshman group picture is taken at the Alva campus at about noon on Saturday, Northwestern's Registry Office will be open from noon to 1:30 p.m. to provide copies of class schedules and answer questions. They will not be able to process enrollments or drop/add on that day. The Financial Aid Office will be open to accept paperwork and answer questions. The Business Office will be open to accept payments, Residence Hall deposits, and answer any questions. The Bookstore will be open to purchase books or Northwestern gear or students can visit the Northwestern homepage and purchase their books online.
Northwestern's Student Government Association will sponsor a week of fun events for students at the Alva campus.
The Monday following student orientations will kick off the Alva campus Howdy Week excitement with "Aloha Northwestern" for all Northwestern students. At 5 p.m. on Monday, Aug. 22, near Coronado Hall will be a cookout, slip n' slide, dunk tank, volleyball tournament and music.
Day two of Howdy Week will be "Movie Night" at 8:30 p.m. on Tuesday, Aug. 23. Just south of Coronado Café will be a movie playing for students, topped off with corndogs and popcorn. Students are encouraged to bring a blanket to sit on.
"Paint the Town Red" is day three of Howdy Week. At 3:30 p.m. Wednesday, Aug. 24, a scavenger hunt, drawings with prizes and pizza will be waiting for students at the Intramural Field.
On the fourth day the campus "Block Party", with a cookout and music, will take place Thursday, Aug. 25, from 7:30 to 11:30 p.m. on the street between South Hall and Coronado Hall.
The Club Fair will end Howdy Week from 11:30 a.m. to 1:30 p.m. on Friday, Aug. 26. Students will get to meet with clubs and organizations while enjoying a free sno-cone.
The last day to add a 16-week course at Northwestern is Aug. 30. Course schedules can be found online at www.nwosu.edu/course-schedules.
All first-time freshmen must enroll in a Ranger Connection class. Ranger Connection classes are listed under University Studies in the fall schedule and serve as an orientation to the university and college life.
For more details on Freshman or Transfer Student Orientation please visit www.nwosu.edu/freshman-transfer-orientation.
Additional questions should be directed to Calleb Mosburg, dean of student affairs and enrollment management, at (580) 327-8415 or firstname.lastname@example.com; Dr. Deena Fisher, dean of the Northwestern-Woodward campus, (580) 256-0047 or email@example.com; or Candace Reim, Enid student services coordinator, at (580) 213-3147 or email@example.com.
For those attending the University Center at Ponca City, please contact Ellan Edwards at (580)718-5600.
MISSION STATEMENT: Northwestern Oklahoma State University provides quality educational and cultural opportunities to learners with diverse needs by cultivating ethical leadership and service, critical thinking and fiscal responsibility.


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By Adam Ozimek
I've been trying to pin down where Fitch stands on a downgrade. On the one hand, in the wake of the debt ceiling being raised, Fitch and Moody's were said to reaffirm AAA rating. Media outlets were reporting it like this:
Moody's Investors Service and Fitch Ratings reaffirmed their triple-A rating for the United States…
On the other hand, Fitch said a full review was under way and would be completed within a month. So might the full review include a downgrade, or is that off the table as the AAA rating has been reaffirmed? A quote from a Fitch spokeperson clears this up:
Analysts from Fitch Ratings were in their offices over the weekend, churning through financial data. The company has said it may take all month to decide. "Our rating is triple A until the day it changes," said David Riley, the head of global government debt at Fitch Ratings from his office in London. "That being said, we haven't formally reaffirmed the rating."
Moody's reaffirmed the country's AAA, though it did put the country on negative outlook on Tuesday. The company's sovereign analyst said Saturday the company is not as concerned about political gridlock.
So despite media reports like those above, Fitch has not "formally reaffirmed" the AAA rating, and a downgrade appears to be on the table for their upcoming review.
One thing to consider is that an S&P downgrade could make a Fitch downgrade more or less likely. If this spurns politicians to action, it will have helped fix the problem it identified, effectively falsifying itself. However, if the downgrade causes rates to increase or hurts the economy through weaker consumer sentiment or some other Animal Spirit / Confidence Fairy effect, then it would make our fiscal situation even worse.
But what would cause Fitch to downgrade? Reports indicate they are less concerned about political gridlock, and appear to be focused on whether either the super committee's $1.5 trillion in desired cuts or the automatic trigger backup plan will materialize. But how much clearer will that become within the next month? Are there any signals Washington could send that would indicate they're likely to back out of these cuts?


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Prices, specials, features and availability subject to change.
Enjoy all the comforts of your own private home, with the services and amenities of a professionally managed community! Conveniently located just a few minutes northwest of Minneapolis in Plymouth, our residents enjoy countless benefits that our location offers, such as easy access to and from I-494, I-94 and Hwy 169, as well as spectacular shopping and dining at the nearby Arbor Lakes area in Maple Grove! * With five unique floor plans featuring two or three spacious bedrooms, our community offers something for everyone! Each of our private, rental-only townhomes include ground-level entry, walk-out patios, abundant closet space, fully-equipped kitchens with full-sized dishwashers and built-in microwaves, cable television and high-speed internet hook-ups, full-sized washers and dryers, attached single-stall garages, and individually controlled heating and air conditioning. * We provide on-site management 7 days a week, full maintenance service, seasonal lawn care/snow removal services, as well emergency maintenance service outside of business hours. Our residents enjoy access to our Community Clubhouse, featuring a 24-hour State of the Art Fitness Center luxurious Resident Lounge, and seasonal Outdoor Patio with Gourmet Grill. The 38-acre community also features a resort-style Heated Outdoor Pool with Sundeck, Off-Leash Dog-Park, Sport Court with Tennis and Basketball Courts, lush courtyards and scenic trails throughout. Stop by for a tour, we can't wait to welcome you home to Bass Lake Hills!
Our lease terms are: 12 months (Please note that lease terms may vary, are subject to change without notice, and are based on availability. Inquire with property staff for complete details).
Cats Allowed. Pets Accepted. Dogs Allowed. Call for service animal policy.
284 units
Contact Propertyor call
The townhome was in good shape and the staff was very responsive to maintenance requests or any other issues. Read MoreVery friendly and approachable.
November 12, 2014
The staff and residents are great. Friendly helpful. I love living there. I have meet new people who are now f Read Moreriends. And the staff has been there whenever I needed something fixed or changed.
November 12, 2014
Old appliances, old cupboards, old fixtures! The apts were quiet though! Neighbors smoked in their garage so i Read Moret always smelled like smoke in our garage.
November 12, 2014
Next to a busy street Appliances in poor condition/ break easily Office Staff left a lot to be desired Not Read Moreenough insulation/ noise issues Smoking permitted indoors
November 12, 2014
Was told prior to moving in the apartment would be updated - granite, s s appliances, flooring and bathrooms r Read Moreedone. None of this was completed.
June 21, 2014
Monday-Thursday: 9:00am-6:00pm
Friday: 9:00am-5:00pm
Saturday: 10:00am-5:00pm
Sunday: 12:00pm-5:00pm
CSM Corporation
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... the books that is, of course... Actually, that's just an excuse to post this brilliant Youtube video. It's basically a music video for the song 'Head of Steam' by Polly and the Billets Doux, a local(ish) group based in Winchester. I was told to look this up by the brother of the woman in the video who is a bookbinder of my accquaintance. The video was basically made in her bedroom with things that came to hand...
Saturday, June 26, 2010
A New Use for Penguins...
2 comments:
- clive Hicks-Jenkins said...
What a delightful video. Utterly charming. I was more engaged by the quirky invention of this little film, conjured out an eclectic collection of ephemera, than the three interminable hours of bloated guff in Avatar. Well done everyone concerned. And well posted John!
- 8:24 am
- clixchix said...
Callum, I meant "And well posted Callum", not "Well posted John"!
Brain dysfunction along the lines of "Which blog am I on? Who am I writing to? Who am I?" !!!
- 7:46 am
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There are only three weeks to go until the final USA TODAY/National High School Coaches Association Super 25 High School Wrestling Rankings are released, but this weekend will shape the national championship chase.
Top-ranked Blair Academy (Blairstown, NJ) and No. 2 Wyoming Seminary (Kingston, PA) will square-off at the National Prep Championships at Lehigh University in Bethlehem, Pennsylvania. Blair, which beat SEM in its dual meet, has won 34 of the last 35 national prep titles. Wyoming Seminary broke Blair's streak of 33 straight championships two years ago. Also competing at Lehigh will be No. 24 Malvern Prep (Malvern, PA).
As far as this week's rankings, there are no changes, but with the New Jersey, Ohio and Pennsylvania individual championships being wrestled over the next two weekends, expect some shifting.
In Minnesota this weekend, all eyes will be on the AAA Team Duals where No. 15 Apple Valley (Apple Valley, MN) and No. 20 St. Michael-Albertville (Albertville, MN) could meet in the finals.
In Texas, kudos to No. 25 Allen (Allen, TX), which won its seventh straight team University Interscholastic League individual team title. The Eagles scored 230.5 team points, the second most team points in UIL State
History behind its own record of 251.5 points. Allen had five state champs and twelve state place winners.
NHSCA/USA TODAY Super 25 High School Wrestling Rankings
Week 11
#1 Blair Academy (16-1)
Blairstown, New Jersey
Previous: #1
#2 Wyoming Seminary (13-1)
Kingston, Pennsylvania
Previous: #2
#3 Graham (14-0)
St. Paris, Ohio
Previous: #3
#4 Bethlehem Catholic (20-1)
Bethlehem, Pennsylvania
Previous: #4
#5 Bergen Catholic (16-2)
Oradell, New Jersey
Previous: #5
#6 Buchanan (10-0)
Clovis California
Previous: #6
#7 St. Edward (26-2)
Lakewood, Ohio
Previous: #7
#8 Oak Park River Forest (24-3)
Oak Park, Illinois
Previous: #8
#9 Clovis (12-3)
Clovis, California
Previous: #9
#10 Belle Vernon Area (18-2)
Belle Vernon, PA
Previous: #10
#11 Lake Highland Prep (3-2)
Orlando, Florida
Previous: #11
#12 Tuttle (15-3)
Tuttle, Oklahoma
Previous: #12
#13 Mount Carmel (21-0)
Chicago, Illinois
Previous: #13
#14 Poway (8-0)
Poway, California
Previous: #14
#15 Apple Valley (17-1)
Apple Valley, Minnesota
Previous: #15
#16 Washington Community (14-6)
Washington, Illinois
Previous: #16
#17 Marmion Academy (19-5)
Aurora, Illinois
Previous: #17
#18 Carl Sandburg (17-2)
Orland Park, Illinois
Previous: #18
#19 Elyria (13-1)
Elyria, Ohio
Previous: #19
#20 St. Michael-Albertville (19-3)
Albertville, Minnesota
Previous: #20
#21 Boyertown (22-1)
Boyertown, Pennsylvania
Previous: #21
#22 Nazareth (19-4)
Nazareth, Pennsylvania
Previous: #22
#23 Archer (17-0)
Lawrenceville, Georgia
Previous: #23
#24 Malvern Prep (14-1)
Malvern, Pennsylvania
Previous: #24
#25 Allen (5-0)
Allen, Texas
Previous: #25
Receiving consideration (alphabetical) – Anoka (Minnesota); Brownsburg (Indiana); Camden County (Georgia); Delta (Ohio); Fort Dodge (Iowa); Kasson-Mantorville (Minnesota); Kiski Area (Pennsylvania); Pomona (Colorado); Southeast Polk (Iowa); Warren Central (Indiana); West Des Moines Valley (Iowa)
Editor's Note: The NHSCA/USA TODAY Super 25 national high school wrestling rankings are produced by High School Football America's Jeff Fisher and Corey Haddad for the National High School Coaches Association and USA TODAY High School Sports.
Jeff Fisher
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By Susan Wloszczyna, USA TODAY
The Mission: Impossible team has nothing on Team Tom.
IS TOM LESS OF A TOP GUN? Actor's favorable ratings drop
When word got out that a USA TODAY/Gallup Poll showed Tom Cruise's favorability rating had slipped 23 percentage points in the past year, Hollywood's power elite picked up the phone, from producers (Jerry Bruckheimer) to studio chiefs (Alan Horn of Warner Bros.). What some had to say about whether public perception of Cruise affected the box-office performance of Mission: Impossible III:
• "He spent years not speaking about his private life, not discussing his Scientology beliefs and was criticized for that. He made the decision to talk about such topics, and now he is prodded into saying certain things. He answers the questions put to him." —Paula Wagner, Cruise's longtime production partner
• "The reason we made Mission is that Tom is clearly the most profitable and substantial movie star in the world. We made $118 (million) worldwide. I don't know, but where I come from, that is a lot of money. If Tom Cruise is doing a picture, I want to talk about it. I would absolutely make a fourth Mission." —Brad Grey, chairman and CEO of Paramount Pictures
• "I've read all the reports about a disappointing opening. Anytime you get close to $50 million, it's worth celebrating. It's very hard to get those openings on a non-holiday weekend. ... When the public learns too much about a star, it's dangerous for the whole business. You're hiring a mystique. No one is as attractive as they are portrayed." —Ron Meyer, president and COO of Universal Pictures and Cruise's former agent


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12x12 cut in half for tractor body and 6x6 cut in half for cab. This was for a 78th birthday of a man that used to build John Deere Tractors.
Hay and Wheels are made of Rice Krispie treats and covered in fondant.
John Deere Tractor Cake
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