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3 days left!!! Except for the lucky ones who get the AC3 pre-orders tomorrow or in two days. Anyways, a lot of people have been saying how certain settings wouldn't work for an AC game such as world war 2 or the cold war because they think the gameplay would have to be changed too much which would make it a shooter or Splinter Cell game.
I made a blog about how world war 2 would work without having drastic changes to gameplay and to make it unique compared to other games set in WW2.
Personally, i think Ubisoft should at least attempt certain settings in the form of DLC for one of their games, downloadable games so people can rate on if they like it or a full AC game with multiple settings. If it's popular then they could try out some of the settings for future AC games.
These settings could include:
Stone age (7000 BC)
After the solar flare catastrophe, the human race needs energy when the winter approaches so tribes start fighting against each other for possession of a Piece of Eden. These would be the first assassins after Adam and Eve and the first Templars after Cain.
The missions would include infiltrating other tribes and escaping a thawing glacier.
Ancient civilizations (3000 BC)
Ancient Egypt would be perfect for an AC game and it wold be fun doing a leap of faith off a Pyramid
Missions would include Passing through human judgement tests in tombs to reach a Piece of Eden and assassinate a Templar in the Nile.
Modern day (1900s-now)
A Cold War setting sounds cool to try out because of the large number of events like the Civil Rights movements and the Space Age.
They could use missions such as assassinating an apartheid member in South Africa and infiltrating NASA although we all know what will happen... Assassin-Templar fight in SPACE!!!
Human-First Civilization War (Pre 75000 BC)
Wouldn't it be cool to fight Those Who Came Before. It would show the first Assassins and Templars. Think about it, thousands of Humans vs hundreds of the First Civilization.
Assassins learn to be stealthy to capture a Piece of Eden since that's their only way to victory. It could also show if the Human-First Civilization hybrids were planned and how the First Civilization's technology was different to the Humans. e.g The Animus.
Maybe even go as far back in the DNA to play as the First Civilization showing how the Humans were created and how the war started.
They could include missions like engaging head on with the First Civilization with most of the Human race and going around the frontlines to steal a Piece of Eden.
Well there you have it. Do you think Ubisoft should try this out sometime?
Thanks for reading. Hope you enjoyed.


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The vast majority of Culfordians go on to University on leaving the school. Our Sixth Formers take up places on a wide range of competitive courses at many excellent Higher Education institutions including Oxford and Cambridge and other Russell Group universities.
Culfordians go on to a wide range of careers; from banking to medicine, from the arts, journalism and marketing to research science, engineering and the teaching professions. There are Old Culfordians in rock bands and others in the House of Commons!
Alongside their A Level courses and other activities, all the Lower Sixth take part in a week-long Life After Culford programme. The event seeks to equip pupils with the knowledge, information and support that they need to make an informed decision about what they do after they leave Culford. Find out more here:
life after culford programme
Many of Culford's students go on to study at Russell Group universities and Oxford and Cambridge remain the destinations for the most able students. We are also supportive of students who aim to take courses at other universities, Drama School, Art College or join the Forces. Others choose to study abroad and three former pupils recently took up competitive Tennis Scholarships at US Colleges.
recent leavers' destinations
All those who leave Culford become Old Culfordians; members of a vibrant and connected alumni community. Old Culfordians are cared for by the Foundation department who hold frequent events and reunions, and produce an annual magazine, FOCuS, and bimonthly email newsletters.
find out more about the foundation here

subset: commoncrawl


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Scion iQ Slammed in Consumer Reports Ratings
Consumer Reports seems not to enjoy testing sub-compact cars such as the Scion iQ and the Smart ForTwo, or at least that's how it looks.
Of all the new cars the publication has reviewed, the Smart ForTwo is at the very bottom with a rating of 28 and the Scion iQ is well, not much better at 29. This is a little surprising considering when we reviewed the Scion iQ, we found there was plenty to like about the model and certainly there are things it does well compared to its competitors.
Undoubtedly Consumer Reports didn't review the Scion iQ with city driving in mind, which is evident when it said the vehicle's powertrain was "barely enough to stay up with highway traffic."
There's a reason the iQ is referred to as a city car for urban environments such as those found in San Francisco, New York, or Boston. Perhaps it would have done a little better if Consumer Reports reviewed the model through the perspective of a city-dweller, and not trying to cruise the highway at 70 mph.


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467 pages, Tabs
Phosphorus is an essential element for plant growth and its input has long been recognised as necessary to maintain profitable crop production. However, phosphorus inputs can also increase the biological activity of surface waters and this can lead to the destruction of such aquatic ecosystems. Advanced eutrophication of surface water leads to problems with its use for fisheries, recreation, industry and drinking, due to the increased growth of undesirable algae and aquatic weeds, and oxygen shortages caused by their death and decomposition. It is therefore important to have a good understanding of the causes and mode of phosphorus loss from soil to water, to enable the problems to be controlled and managed.
"[This book] provides a comprehensive reference resource on the state of knowledge concerning the processes and mechanisms associated with phosphorus losses from fields and catchments....The book is essential reading for all soil scientists and agronomists as well as those in the fertilizer industry. It is also a thought-provoking resource for environmentalists, ecologists, and agriculturalists concerned with sustainable land management."--Journal of the American Water Resources Association
"I recommend this book for those scientists and managers interested in the biogeochemistry of phosphorus, the movement of P and other pollutants through the landscape, nonpoint-source pollution, and the role of agriculture in aquatic eutrophication. The book provides an interesting mix of process-level studies, landscape and watershed analysis, and management concerns. The book succeeds in making a strong case for the importance of agriculture in P losses to aquatic ecosystems, and discusses
There are currently no reviews for this product. Be the first to review this product!


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The Carolina Epicurean
Imagine asking a friend if they've been to a restaurant and what they thought of it. Or where would your friend recommend going for a really great lunch. The Carolina Epicurean is your online resource for restaurant reviews, news and food trends in western North Carolina, and beyond.
Carolyn Sakowski's Touring Backroads
Whether you are an armchair traveler, a history buff, or a motorist looking for an alternative to crowded highways, Carolyn Sakowski's Touring the Western North Carolina Backroads will take you to unforgettable places and introduce you to memorable characters and events.


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4 CVs in AU-3351 Snake Valley (Victoria).
Get the latest CVs in Snake Valley via email.
senior team memberBallarat, Victoria Administration, customer service, stock control,payroll,telephone,banking, HAVE BEEN MADE REDUNDANT ON 20TH APRIL AND LOOKING FOR FULL TIME WORK. [more]
Sales / Customer ServiceBallarat, Victoria Customer Service - 4yrs Sales - 4yrs Telecollector Enquiries Clerk Filing Clerk Trainee Underwriter Recptionist [more]
Administration and Office WorkBallarat, Victoria Busy Reception Area Telephone Answering 7 In/5 Out Typing Confidential Correspondence Typing General Correspondence Typing Quotations Electronic/General Mail Distribution Banking EFT transactions EFT reconciliation Petty Cash Maintain Stationery Supplies Maintain Staff Amenities Arrange ... [more]
System Administrator,HR ManagerBallarat, Victoria Organization: NATIONAL INSTITUTE OF COMPUTER SCIENCE & TECHNOLOGY Duration: 01.06.2009 to 30.09.2010 Designation: Jr. Manager (HR) Job profile: It was a part time job. In this Organization I have to handle the disputes arising in the Institute by the students and also by the faculties. On the o... [more]
Results 1 to 4 of 4 resumes


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Dc Comics Wonder Woman She Can Do It! Poster
Official Merch
(approx. $5.37 or €4.78)
- Only 1 left in stock - order soon!
- No Worries 14-Day Exchanges
- Official Merchandise
Fast Delivery by Royal Mail (3-5 Days)
Buy now for fast delivery
Product Info
Wonder Woman is breaking free from her chains! This awesome poster from DC Comics is a parody of the famous Howard Miller advertising poster, Wonder Woman is pictured smashing her chains apart with the words 'She Can Do It!' above her. She has been a feminist icon since she was introduced back in 1941 and if she is your favourite superheroine then this is a must have for your wall.
- Size: 61cm x 91.5cm
- Product Type: Poster
- Product Code: 84749


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Contextura Vehicular La altura máxima de todo vehicular cera de 4.3 metros excepto los buses de 2 pisos que sera de 4.5metros Ningun vehiculo pobra circular si la carga sabre sale lataralmante La parte del tubo
escape de un
de un autobus tiene
que estar en un angulo
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Page 2 of 4
I thought I was onto something special when I stumbled across the website of a brash female guide from Washington state. She had a chip on her shoulder about the lack of respect she felt she received in the male-dominated world of salmon and steelhead guiding, and offered numerous anecdotes suggesting her equality—if not superiority—to her male peers. Numerous self-portraits on the site additionally suggested that she harbored few qualms about using her sexuality to further her business prospects. The takeaway—I'm paraphrasing here—was why hire a male guide when you can get the same or better results with me? I'm hot!
That attitude set off alarms among my female colleagues, but after lengthy consideration I made the call and scheduled a shoot with the guide—let's call her Athena. I figured we'd get a great story if Athena turned out to be all she said she was. And if she wasn't, we'd still have a star who would fuel nearly every male angler's (other) wet dream: a hot chick with a fly rod.
- John Aaseng
- Jon Aaseng filming Magnum Hunt Club member John McKnight on a British Columbia mountain goat hunt.
There are innumerable challenges to making outdoor television, but the biggest impediment is almost always the budget, or lack thereof.
Ratings for outdoor networks aren't usually robust enough to command the attention of national advertisers, and so the ad landscape of outdoor TV is dominated by niche products: guns, ammunition, bows, rods, lures, boots, knives and the like. The companies that make and market these products tend toward the shallow end of the national advertising pool and, as a result, production budgets for outdoor shows are a fraction of those for mainstream television.
The job of nurturing a series from conception to delivery falls on the producer, who finds storylines, determines locations, arranges travel and lodging for the host and crew, and works with editors to put the show together. Since the vast majority of outdoor shows are sponsored—production companies typically purchase airtime and then solicit sponsors to offset the cost—producers have to also be adept at managing relationships with sponsoring companies that may care more about product exposure than creative content.
Due to budget constraints and the logistical need to keep crew size to a minimum, producers are often unable to accompany their crews on shoots. When the producer stays home, responsibility for field production falls on the cameramen. A standard outdoor shoot requires one or two videographers and maybe a production assistant/audio tech on location. On multiple-camera shoots, one videographer, usually the most experienced, will take the lead. On one-camera shoots—typically remote or stealth hunts—the lone videographer is a one-man band, responsible for all video, audio and field direction. The entire responsibility for content-gathering falls on a single individual; if they don't return with enough quality footage to make a show, there will be hell to pay.
- Matt Young
To get that footage, shooters coordinate and direct the on-screen talent, be it host or guest. They record all pertinent action, from travel shots and set-ups to scouting missions and distant animals, kill shots to hook-ups, interviews to transition-easing B-roll.
In addition to finely tuned creative chops and discipline, field crews are also highly advanced in terms of general badassery. They pack upwards of 50 pounds of gear over every kind of terrain on the planet. A Barrett Productions crew once spent 10 days in the high mountains of Kyrgyzstan on an ibex hunt, getting shuttled by outdated Soviet helicopters and military vehicles and humping up 13,000-foot peaks. Field crews brave conditions that would cripple normal humans: musk ox hunts at 40 below zero in the Arctic Circle; September bow hunts in temperatures approaching 100; black bear hunts in the impenetrable tangles of the Yukon; African safaris dodging blast-furnace temperatures and angry man-eaters alike.
The job isn't without its rewards, of course—getting paid to travel to some of the most stunning landscapes on the planet is a hell of a perk—but the faint of heart, leg or eye need not apply.


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Rumor has it that LIL-KESH of ybnl refuses to jump on a rap dancehall track with CASINO and SAMBOY. Sources say lil kesh dropped by in the studio when the music producer nd rapper Casino was working on a joint with samboy (famous ibadan rapper).
on hearing the beat, keshy got into freestyling which made casino and samboy join in too but as the heat was on keshy wasnt enjoying much of his lines as the duo (casino and samboy) kept lashing out bazuka lines which got oda rappers in the studio hailing them more than keshy.
Lil-kesh opted out of the studio and refused to do a verse on the beat, as he had an interview that same day, that was his excuse for not doing a verse.we dont knw how true this is. But reliable sources confirmed this to our correspondents
Could this be true? Or is it that Lil-Kesh is not capable to be among YBNL?
Pls share your comment!!!


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Non-Drying Silicone!
SPUNK Lube Pure Silicone is non-drying during use. It's a special blend of 100% pure clear silicone that will out last you!
SPUNK Lube Pure Silicone is sex toy safe, non-staining & softens your skin. It's silicone based but cleans up much easier than traditional silicone based lube because it doesn't contain any additives or preservatives. It's free from glycerin, parabens & propylene glycol.
SPUNK Lube Pure Silicone is perfect! It doesn't get sticky or tacky and it's also safe to use with ALL materials. It's great for sensitive skin and it feels amazingly smooth.


text:
Quick Links
The article you requested is
Association of Adverse Childhood Environment and <i>5-HTTLPR</i> Genotype With Late-Life Depression
Karen Ritchie, PhD; Isabelle Jaussent, MSc; Robert Stewart, MD, PhD; Anne-Marie Dupuy, MD, PhD; Philippe Courtet, MD, PhD; Marie-Laure Ancelin, PhD; and Alain Malafosse, MD, PhD
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Objective: Neurobiological and clinical studies suggest that childhood maltreatment may result in functional and structural nervous system changes that predispose the individual to depression. This vulnerability appears to be modulated by a polymorphism in the serotonin gene–linked promoter region (5-HTTLPR). Little is known, however, about the persistence of this vulnerability across the life span, although clinical studies of adult populations suggest that gene-environment interaction may diminish with aging.
Method: Depressive symptomatology and adverse and protective childhood events were examined in a population of 942 persons aged 65 years and older, taking into account sociodemographic characteristics and proximal competing causes of depression (widowhood, recent life events, vascular and neurologic disorder, and disability). Subjects were recruited between March 1999 and February 2001 and were diagnosed as depressed if they met 1 of 3 criteria: a diagnosis of major depression on the Mini-International Neuropsychiatric Interview, a score higher than 16 on the Center for Epidemiologic Studies-Depression Scale, or current treatment with an antidepressant.
Results: Exposure to traumatic events in childhood doubled the risk of late-life depression and increased the risk of repeated episodes. Not all events were found to be pathogenic; significant risk was associated with excessive sharing of parental problems, poverty or financial difficulties, mental disorder in parents, excessive physical punishment, verbal abuse from parents, humiliation, and mistreatment by an adult outside the family. Interactions were observed between the 5-HTTLPR long (L) allele, poverty, and excessive sharing of parental problems.
Conclusions: Certain types of childhood trauma continue to constitute risk factors for depression in old age, outweighing more proximal causes. Gene environment vulnerability interaction is linked in older age to the L-carrying genotype, modulating the effects of general environmental conditions rather than aggressive acts on the individual, perhaps due to increased cardiac reactivity.
Submitted: July 1, 2008; accepted September 15, 2008.
Online ahead of print: June 30, 2009.
Corresponding author: Karen Ritchie, PhD, Inserm U888 Pathologies of the Nervous System, La Colombière Hospital, 39 Avenue Flahault, BP 34493, 34093 Montpellier Cedex 5, France (email@example.com).
Association of Adverse Childhood Environment and 5-HTTLPR Genotype With Late-Life Depression
J Clin Psychiatry 2009;70(9):1281–1288
© Copyright 2009 Physicians Postgraduate Press, Inc.
Online ahead of print: June 30, 2009 (doi:10.4088/JCP.08m04510).
Neurobiological studies have demonstrated that childhood maltreatment may alter brain development by programming the glucocorticoid, noradrenergic, and vasopressin stress response systems to overreact to new stressors,1–3 thus rendering the individual increasingly vulnerable to psychiatric disorder. These effects appear to be long-lasting,4 inducing structural and functional changes, notably reduced development of the hippocampus and amygdala, and abnormal frontotemporal electrical activity.2 As these brain structures have also been implicated in the etiology of depression, it is not surprising that child abuse has been associated with increased risk for depression during childhood and also in early adulthood.5,6
Not all children exposed to traumatic experiences subsequently develop psychopathology, and accumulating evidence suggests that vulnerability for depression is influenced by variation in the serotonin transporter gene (5-HTT).7,8 A functional insertion/deletion polymorphism in the serotonin gene–linked promoter region (5-HTTLPR) has been shown to modify the association between stressful life events and depression onset.7 The 5-HTTLPR short (S) allele appears to reduce in vitro transcriptional activity of 5-HTTLPR, resulting in decreased expression of 5-HTT. Most replication studies have confirmed this original finding, although a few have not, particularly when older subjects have been included.9 It has also been observed that a supportive early environment appears to reduce symptomatology in S/S homozygous subjects exposed to childhood trauma.8,10
Clinical studies of child abuse have focused on the implication of these events in childhood and adolescence on the assumption of a proximal effect of life events on psychological health. Little is known about the persistence of this vulnerability across the life span and whether adverse childhood events continue to constitute a significant risk factor for depression in old age. The role of the 5-HTTLPR genotype in mediating the late-life impact of child abuse is also uncertain. In a small community sample of 194 elderly subjects, depressive symptoms were observed to be associated with abuse and neglect in childhood11; however, the sample size was too small for adjustment for other possible causes of depression. A study by Surtees et al12 combining childhood and adult life events in a sample with an age range of 41 to 80 years found a strong relationship between childhood events and recent episodes of major depression. No interaction effect was found with 5-HTTLPR genotype; however, a trend was observed in the opposite direction, with the long (L) allele constituting the interactive risk factor in men. Taylor et al13 noted that, in elderly persons with depression, smaller hippocampal volume was associated with earlier depression onset and the S/S genotype, as opposed to late-onset (over 50 years) depression, in which reduced hippocampal volume was associated with the L/L genotype. Traumatic events were not examined.
Studies to date thus suggest that gene-environment interaction in the genesis of depression may not be the same in elderly populations as in childhood and young adults. Furthermore, while candidate environmental pathogens are generally considered to have greater impact when they are proximal to depression onset,14 biologic evidence suggests that childhood trauma, occurring at critical stages of brain development, may lead to more permanent structural and functional changes. The present study aims to examine the relationship between childhood trauma and late-life depression in an elderly general population cohort, taking into account other more proximal risk factors for late-life depression, and 5-HTTLPR genotype interaction. Adverse childhood events are examined individually along with potential environmental protective factors.
Community-dwelling persons, 65 years and older, were recruited by random selection from the 15 electoral roles of the Montpellier District, France, between March 1999 and February 2001 as part of the Esprit study of late-life psychiatric disorder.15 Refusers (of whom 3.3% were excluded due to severe disability) were replaced by another subject drawn at random from the same electoral division such that each division was equally represented. Subjects refusing were slightly older and more likely to live alone than nonrefusers. Subjects were subjected to a baseline examination and reexamined on 2 further occasions at 2-year intervals.
Participants were asked to attend a half-day examination by a neurologist and a center interviewer (nurse or psychologist) at the Gui de Chauliac Neurology Hospital (Montpellier, France). Disabled subjects unable to come to the study center were interviewed in their homes. The following procedures were carried out:
Standardized health interview. The health interview covered the participant's present state of health, individual and family medical history, and medication use—subjects were asked to bring their medication to the center and the type of medication was noted according to the World Health Organization's Anatomic Therapeutic Chemical Classification.16 Disability was assessed by the Lawton Scale for Instrumental Activities of Daily Living (IADL).17 Exposure to adverse life events in the past year was assessed using the Gospel Oak questionnaire,18 a 12-item list of major adverse events covering bereavement, rupture in significant relationships, financial and legal problems, dismissal, severe illness, and loss of a highly valued object.
Standardized neurological examination. The neurological examination was based on International Classification of Diseases, Tenth Revision criteria19 and was designed to detect neurologic and cardiovascular comorbidity, including measures of sitting and standing blood pressure. It was carried out at baseline and at each follow-up examination.
Standardized psychiatric interview. The Mini-International Neuropsychiatric Interview (MINI) (French version 5.00)20 was used to record lifetime and current DSM-IV Axis I psychiatric disorder.21 The MINI has been validated within the French general population setting.21 Positive cases were reviewed by a panel of psychiatrists. The Center for Epidemiologic Studies-Depression Scale (CES-D)22 was used to detect high levels of depressive symptomatology. Case-level late-life depression was defined as a MINI diagnosis of current major depression, a score above the 16-point cutoff on the CES-D, or current treatment with an antidepressant at baseline or at each follow-up examination.
Childhood environment self-report. A retrospective self-report questionnaire examining traumatic experiences during childhood and adolescence based on a review of existing instruments and covering 25 adverse and 8 protective factors was given to subjects for completion in the third wave of the study (4 years after recruitment), by which time the study interviewers had established close relationships with the cohorts, facilitating the request for sensitive information. Subjects were asked to respond yes or no to each item. Subjects were also given an opportunity to discuss the questionnaire contents with interviewers in case of doubt as to whether specific experiences corresponded with the items. Adverse factors included verbal abuse from parents and physical and sexual abuse, conflict at home, strict education, mental cruelty, neglect, mental disorder in parents, excessive sharing of parental problems, illness, poverty, mistreatment at school, separation, and war or natural catastrophe. Protective factors included maternal and paternal affection, availability of an adult friend, impression of having had a happy childhood, parents perceived as doing their best, feeling happy at school, and having been raised by both parents.
Subjects were reexamined on 2 further occasions at 2-year intervals. At follow-up, the neurological and psychiatric examinations were repeated and medication use and incident illness were recorded. The Gospel Oak questionnaire was used to record life events occurring since the last examination. The present study was carried out on the 942 subjects for whom complete information was available on all variables used in the analyses (clinical examinations at all time points, childhood environment, genotype, depression measures, and all potential confounding variables). Ethics approval for the study was given by the national ethics committee. All subjects gave their signed consent for participation in the study.
DNA collection. Blood samples for DNA collection for 5-HTTLPR genotyping were taken after the baseline clinical interview. 5-HTTLPR insertion/deletion polymorphisms were assayed in 2 stages. Genomic DNA was extracted from white blood cells harvested from 15 mL ethylenediaminetetraacetic acid blood samples using DNA extraction kits from Amersham-Pharmacia Biotech (Buckinghamshire, United Kingdom). Subsequently, amplification of 5-HTTLPR was carried out using the primers HTTLPRF (GGCGTTGCCGCTCTGAATTGC) and HTTLPRR (GAGGGACTGAGCTGGACAACCCAC) in reaction mixtures with a total volume of 25 μL, with 200 ng of genomic DNA, 10 pM of the primers, 120 nM dNTP, containing 7-deaza-dGTP instead of dGTP (Roche, Rotkreuz, Switzerland), 5% dimethyl sulfoxide (Sigma, Buchs, Switzerland), 1.5 mM MgCl2, and 1.25 U Taq polymerase (Eurobio, Brunschwig; Basel, Switzerland). Temperatures were 60°C for 30 seconds for annealing and 72°C for 1 minute for extension. PCR products (8 μL) were subjected to 45 mn electrophoresis at 120V in a PCR CheckIT gel (Elchrom Scientific AG, Cham, Switzerland) before being viewed under ultraviolet light to assess the 5-HTTLPR genotypes. An adenosine/guanine (A/G) single nucleotide polymorphism (SNP; rs25531), located in the close vicinity of 5-HTTLPR, has recently been reported to modify transcriptional activity.23 On the basis of these in vitro functional data, it has been proposed to recode the 5-HTTLPR/rs25531 allele as S' or "low-expressing allele" (SA, SG, and LG) and L' or "high-expressing allele" (LA).24 As this new allelic dichotomy still awaits replication in in vivo studies, we initially examined both allelic systems (S/L and S'/L') within the present study. Recoding did not significantly alter results, so we report here only analyses relating to S and L.
Statistical Analysis
Univariate logistic regression was used to determine differences in unadjusted social and clinical characteristics between participants with and without depressive symptomatology. Variables found to be associated with current depression were used as adjustment variables in analyses relating to the association between childhood events and current depression. Polytomous logistic regression models were used to model the relationship between the number of depressive episodes (0, 1, 2 or more) and individual childhood events (binary) and to calculate the odds ratio and its 95% confidence interval (CI) for lifetime onset of a major depressive episode in relation to childhood events. The distribution of 5-HTTLPR was tested by χ2 for Hardy-Weinberg equilibrium.
We tested the hypothesis that 5-HTTLPR genotype might modify the relationship between depressive symptomatology and childhood events using a logistic regression model. We therefore stratified our analysis by 5-HTTLPR genotype and then added the interaction term to the full model and tested for its significance using Wald χ2 test given by the logistic regression model. Significance level was set at P < .05. The statistical analysis was carried out using SAS software, version 9.1 (SAS Institute Inc, Cary, NC).
The median (range) age of the sample was 72 (65–92) years. In this study, 38.4% of subjects scored over the cutoff point on the CES-D either at recruitment or at 1 of the 2 follow-up examinations, 23.5% had been diagnosed with major depression during their lifetime, and 12.6% were taking antidepressant medication at some point during the study. All subjects with diagnosed major depression scored over 16 on the CES-D, and 27 subjects (2.9%) taking antidepressant treatment did not meet either MINI or CES-D criteria for depression. These subjects were included as depressed on the assumption that a depressive episode had occurred but had been effectively treated and thus was not detected by the MINI or CES-D. The period prevalence (over the 4-year observation period) of significant depressive symptomatology in this cohort is estimated at 41.3%. The sociodemographic and clinical characteristics of subjects with significant levels of depressive symptomatology are given in Table 1.
Click figure to enlarge
Depressed subjects compared to those without depression were more likely to be female (OR = 2.92, 95% CI = 2.21 to 3.86), to be older than 75 years (OR = 1.60, 95% CI = 1.11 to 2.31), to have medium-low education (OR = 2.07, 95% CI = 1.44 to 2.96), to be divorced/separated (OR = 1.87, 95% CI = 1.17 to 2.99) or widowed (OR = 2.15, 95% CI = 1.56 to 2.96), and to have lower rates of hypertension (OR = 0.59, 95% CI = 0.45 to 0.76). Experiencing adverse life events recently (in the year before and during follow-up) and before the onset of the depressive symptoms showed a significant P value trend. Subsequent analyses were thus adjusted for these competing causes of depression. No significant relationship was found between depression and dementia or other neurologic disorders, disability, recent cardiovascular or cerebrovascular disorder, or 5-HTTLPR allele.
Previous research on child maltreatment and depression has principally highlighted personally threatening events (items 1–6, including physical, sexual, and verbal abuse; Table 2) as being the most pathogenic.25 In this older population, we found that exposure to at least 1 of these events significantly increased risk of late-life depression (OR = 2.28, 95% CI = 1.53 to 3.41). Exposure to a major protective factor (maternal or paternal affection, availability of an adult friend; items 26–28, Table 2) conversely decreased overall risk (OR = 0.54, 95% CI = 0.28 to 1.01).
We also examined the effects of childhood events on the number of depressive episodes occurring during the study period. Exposure to at least 1 adverse childhood event significantly increased the risk of having 1 episode of depression, with an OR = 1.72 (95% CI = 1.04 to 2.86), and for 2 or more episodes, with an OR = 2.89 (95% CI = 1.83 to 4.57) (P value for heterogeneity between these 2 ORs was .05). The presence of at least 1 protective factor gave a risk of OR = 1.03 (95% CI = 0.42 to 2.53) for 1 depressive episode and a protective effect of OR = 0.34 (95% CI = 0.17 to 0.69) for 2 or more episodes (P value for heterogeneity was .02) (data not shown).
The relationship between late-life depression and individual childhood life events was also examined using a logistic regression model. No significant sex interaction effects with individual childhood life events and depressive symptomatology were observed, so analyses were not gender stratified. Table 2 shows that a significant risk was associated with excessive sharing of parental problems with children (OR = 1.53, 95% CI = 1.04 to 2.27); poverty or financial difficulties (OR = 1.65, 95% CI = 1.17 to 2.31); mental disorder experienced by the father (OR = 2.13, 95% CI = 1.32 to 3.44) and mother (OR = 2.52, 95% CI = 1.65 to 3.85); excessive physical punishment for misbehavior (OR = 2.77, 95% CI = 1.41 to 5.46); verbal abuse from parents (OR = 2.90, 95% CI = 1.57 to 5.38); humiliation, harassment, or mental cruelty (OR = 4.31, 95% CI = 1.87 to 9.93); and other mistreatment by an adult outside the family (OR = 6.71, 95% CI = 1.80 to 25.0). A protective effect was observed for maternal affection (OR = 0.45, 95% CI = 0.29 to 0.70) and having the overall impression that parents had done their best (OR = 0.53, 95% CI = 0.30 to 0.92).
The distribution of 5-HTTLPR did not deviate from Hardy-Weinberg equilibrium (χ2 = 0.06, df = 2, P = .97). Interaction effects between 5-HTTLPR genotype and childhood events having a significant relationship with depressive symptomatology were examined, adjusting for age, gender, education, marital status, hypertension, and recent life events, with stratification by genotype.
The risk for depression in relation to too frequent sharing of parental problems with children was increased in LL subjects (OR = 1.93, 95% CI = 0.95 to 3.90) and in SL subjects (OR = 2.00, 95% CI = 1.15 to 3.48), with a nonsignificant tendency for protection in SS subjects (OR = 0.30, 95% CI = 0.08 to 1.19). A comparable pattern was observed in subjects who experienced poverty or financial difficulties. We observed a tendency for an increased risk for depression in LL subjects (OR = 1.51, 95% CI = 0.82 to 2.77), which was significant in SL subjects (OR = 2.54, 95% CI = 1.55 to 4.15). In the SS subjects, we found a nonsignificant tendency for reduced risk (OR = 0.64, 95% CI = 0.26 to 1.53).
Significant gene-event interactions were found in subjects with parents who excessively shared their problems (Wald χ2 = 7.23, df = 2, P = .027) and with poverty or financial difficulties (Wald χ2 = 7.38, df = 2, P = .025) (Figure 1).
As these results suggest a dominant effect of the L-carrying genotypes, we examined the effect of combining LL and LS subjects compared to SS subjects. The risk for depression with childhood poverty was significantly increased in LL/LS subjects (OR = 2.06, 95% CI = 1.42 to 3.00), with a nonsignificant tendency to be reduced in SS subjects (OR = 0.64, 95% CI = 0.26 to 1.53). The risk for depression in relation to too frequent sharing of parental problems with children was also increased in LL/LS subjects (OR = 1.94, 95% CI = 1.26 to 2.98), with a nonsignificant tendency to be reduced in SS subjects (OR = 0.30, 95% CI = 0.08 to 1.19).
Finally, subjects' lifetime risk for major depressive episodes (MDEs) was also ascertained from the MINI, adjusting only for age, education, and gender (life events and hypertension at the time of the episode being unknown). Significant risk factors were found to be, in ascending order, maternal affection (OR = 0.51, 95% CI = 0.33 to 0.79), sharing of parental problems with children (OR = 1.68, 95% CI = 1.11 to 2.54), maternal mental illness (OR = 1.69, 95% CI = 1.11 to 2.59), verbal abuse from parents (OR = 1.94, 95% CI = 1.07 to 3.55), poverty or financial difficulties (OR = 1.97, 95% CI = 1.37 to 2.83), home conflict (OR = 2.09, 95% CI = 1.43 to 3.05), and physical and/or sexual abuse (OR = 2.72, 95% CI = 1.04 to 7.08). Alcohol abuse by father, neglect, and abuse by schoolmates were only significant risk factors for cases of early-onset depression (occurring before age 50 years; data not shown).
Our study of an elderly cohort suggests that adverse childhood events may continue to constitute a significant risk factor for depression throughout the life span. Exposure to traumatic events in childhood was observed to double the risk of late-life depression and increase the risk of repeated episodes. On the other hand, protective factors were seen to diminish the risk of late-life depression and repeated episodes. A relationship between trauma and risk of chronicity has also been observed by Bernet and Stein,5 who found increasing number of lifetime episodes to be also associated with severity of trauma, but numbers in our study were too small to break down number of depressive episodes by individual items.
Recent studies of the impact of life events on psychological functioning have underlined the necessity of examining the impact of individual stressors rather than summating events in aggregate measures due to the differential effect of specific events.26 Our findings support this observation. Of the 25 negative factors studied, late-life depression was found to be significantly associated with only 8: verbal abuse from parents, mental cruelty, excessive punishment by parents, abuse by an adult outside the family, parental mental disorder, poverty, home conflict, and excessive sharing of parental problems with children. Physical and sexual abuse did not quite reach significance; however, only a small number of cases (n = 13) were reported. Maternal affection, impression of having had a happy childhood, and feeling that parents did their best constituted protective factors. These early life events were found to be pathogenic or protective even when potential proximal causes of depression (blood pressure, widowhood and separation, recent life events) were taken into account. No interactive effect was found with sex, although previous studies have reported gender differences in vulnerability to adverse life events occurring later in life.27 Examining individual childhood events and lifetime risk for MDE, we found certain events to be related only to MDE occurring before age 50 years (neglect, paternal alcohol problems, and mistreatment at school by classmates) and others to be related to MDE onset both before and after age 50 years (verbal and physical abuse, maternal mental disorder, and poverty), suggesting some events to have less far-reaching effects than others.
No association was found between 5-HTTLPR and late-life depression. This observation is in accordance with previous meta-analyses suggesting that these polymorphisms do not directly modulate vulnerability to depression.9 Significant interaction was observed, however, between these polymorphisms and some childhood environmental factors. Interestingly, these gene-environment interactions appear to concern more general and long lasting environmental conditions, such as poverty, rather than specific aggressive acts of limited duration. This latter type of event may interact, on the other hand, with genes coding for proteins involved in the development and plasticity of the central nervous system, such as brain-derived neurotrophic factor.28 Most previous human genotype-by-environment studies report a susceptibility (codominant, dominant, or recessive) effect with the S-carrying genotypes.9 On the contrary, in the present population, we found a susceptibility-dominant effect with the LL/LS genotypes. Surtees et al12 reported a similar interaction for past-year prevalent depression and adverse experience in childhood in men—(LL homozygotes) OR = 1.69, 95% CI = 1.17 to 2.44; (LS heterozygotes) OR = 1.26, 95% CI = 0.91 to 1.75. This interaction did not quite reach significance, and the authors suggest this may be due to the fact that it may have occurred predominantly in older subjects, the wide age range of the sample (41–80 years) masking the true effect. Our results lend further support to the hypothesis of a different form of interaction in late-life as opposed to early-onset depression. The L allele has very recently been linked to increased cardiovascular reactivity to mental stress,29 which may in turn lead to subcortical ischemic disease and volumetric changes, notably in the hippocampus. The authors noted, furthermore, that increased cardiovascular reactivity in adulthood was also observed to be associated with childhood poverty.
We conclude from this study that certain types of early childhood trauma continue to constitute risk factors for depression in old age, their effect outweighing more recent life events and other proximal causes of depression. 5-HTTLPR genotype alone does not modulate the effect of highly pathogenic events involving individual victimization, but it may increase vulnerability to global environmental factors such as poverty and excessive sharing of parental problems. Strengths of this study were the large, representative general population cohort, which allowed us to take into account competing causes of depression; analysis of a wide range of individual childhood events; and clinical assessment of late-life depressive episodes. There were 2 principal shortcomings in this study: (1) We assumed that subjects taking antidepressant treatment were depressed, which may not have been the case since antidepressants may be prescribed for other neurologic conditions. This may have weakened the associations examined; however, we could not eliminate these subjects as they would at least in part constitute a successfully treated depressed group. (2) The use of a self-report measure of childhood events may also have weakened the associations examined in this study; prospective data from birth cohorts would have been preferable in terms of reducing recall bias. Further studies of this cohort examining possible biologic correlates of the impact of adverse childhood events, such as persistence of abnormal basal cortisol levels and elevated adrenocorticotropic hormone response, as observed in cohorts of abused children,30 may provide further validation of self-reported adversity and support for the hypothesis that childhood abuse leads to permanent structural and functional changes of the nervous system.
Author affiliations: Inserm, U888, Montpellier and Université Montpellier 1 (all authors); Laboratoire de Biochimie, Hôpital Lapeyronie (Dr Dupuy) and Service de Psychologie Médicale et Psychiatrie (Dr Courtet), Centre Hospitalier Universitaire, Montpellier, France; Institute of Psychiatry, King's College London, United Kingdom (Dr Stewart); and University Hospital and School of Medicine of Geneva, University of Geneva, Switzerland (Dr Malafosse).
Author contributions: Dr Ritchie and Ms Jaussent are joint first authors.
Financial disclosure: Drs Ritchie, Stewart, Dupuy, Courtet, Ancelin, and Malafosse and Ms Jaussent report no additional financial or other relationship relevant to the subject of this article.
Funding/support: The Esprit project, from which the present study's population was drawn, is financed by the regional government of Languedoc-Roussillon, France; the Agence National de Recherche Project 07 LVIE 004; Swiss National Foundation (grant #32-112084); and an unconditional grant from Novartis.
1. Shea A, Walsh C, Macmillan H, et al. Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females. Psychoneuroendocrinology. 2005;30(2):162–178. PubMed doi:10.1016/j.psyneuen.2004.07.001
2. Teicher MH, Andersen SL, Polcari A, et al. Developmental neurobiology of childhood stress and trauma. Psychiatr Clin North Am. 2002;25(2):397–426 [vii–viii.]. PubMed doi:10.1016/S0193-953X(01)00003-X
3. Teicher MH, Andersen SL, Polcari A, et al. The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev. 2003;27(1-2):33–44. PubMed doi:10.1016/S0149-7634(03)00007-1
4. Heim C, Nemeroff CB. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry. 2001;49(12):1023–1039. PubMed doi:10.1016/S0006-3223(01)01157-X
5. Bernet CZ, Stein MB. Relationship of childhood maltreatment to the onset and course of major depression in adulthood. Depress Anxiety. 1999;9(4):169–174. PubMed doi:10.1002/(SICI)1520-6394(1999)9:4<169::AID-DA4>3.0.CO;2-2
6. Kaufman J, Charney D. Effects of early stress on brain structure and function: implications for understanding the relationship between child maltreatment and depression. Dev Psychopathol. 2001;13(3):451–471. PubMed doi:10.1017/S0954579401003030
7. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386–389. PubMed doi:10.1126/science.1083968
8. Kaufman J, Yang BZ, Douglas-Palumberi H, et al. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci U S A. 2004;101(49):17316–17321. PubMed doi:10.1073/pnas.0404376101
9. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry. 2008;13(2):131–146. PubMed doi:10.1038/sj.mp.4002067
10. Taylor SE, Way BM, Welch WT, et al. Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biol Psychiatry. 2006;60(7):671–676. PubMed doi:10.1016/j.biopsych.2006.04.019
11. Kraaij V, de Wilde EJ. Negative life events and depressive symptoms in the elderly: a life span perspective. Aging Ment Health. 2001;5(1):84–91. PubMed doi:10.1080/13607860020020681
12. Surtees PG, Wainwright NW, Willis-Owen SA, et al. Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry. 2006;59(3):224–229. PubMed doi:10.1016/j.biopsych.2005.07.014
13. Taylor WD, Steffens DC, Payne ME, et al. Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry. 2005;62(5):537–544. PubMed doi:10.1001/archpsyc.62.5.537
14. Moffitt TE, Caspi A, Rutter M. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry. 2005;62(5):473–481. PubMed doi:10.1001/archpsyc.62.5.473
15. Ritchie K, Artero S, Beluche I, et al. Prevalence of DSM-IV psychiatric disorder in the French elderly population. Br J Psychiatry. 2004;184:147–152. PubMed doi:10.1192/bjp.184.2.147
16. World Health Organization. World Health Organization Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment. Oslo, Norway: World Health Organization; 2000.
17. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179–186. PubMed
18. Harwood RH, Prince MJ, Mann AH, et al. The prevalence of diagnoses, impairments, disabilities and handicaps in a population of elderly people living in a defined geographical area: the Gospel Oak project. Age Ageing. 1998;27(6):707–714. PubMed doi:10.1093/ageing/27.6.707
19. World Health Organization. International Classification of Diseases, Tenth Revision. World Health Organization; 1992.
20. Lecrubier Y, Sheehan D, Weiller E, et al. The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI. Eur Psychiatry. 1997;12:224–231. doi:10.1016/S0924-9338(97)83296-8
21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
22. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401. doi:10.1177/014662167700100306
23. Hu XZ, Lipsky RH, Zhu G, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006;78(5):815–826. PubMed doi:10.1086/503850
24. Parsey RV, Hastings RS, Oquendo MA, et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry. 2006;163(1):48–51. PubMed doi:10.1176/appi.ajp.163.1.48
25. Teicher MH, Samson JA, Polcari A, et al. Sticks, stones, and hurtful words: relative effects of various forms of childhood maltreatment. Am J Psychiatry. 2006;163(6):993–1000. PubMed doi:10.1176/appi.ajp.163.6.993
26. Rosnick CB, Small BJ, McEvoy CL, et al. Negative life events and cognitive performance in a population of older adults. J Aging Health. 2007;19(4):612–629. PubMed doi:10.1177/0898264307300975
27. Murphy JM, Laird NM, Monson RR, et al. A 40-year perspective on the prevalence of depression: the Stirling County Study. Arch Gen Psychiatry. 2000;57(3):209–215. PubMed doi:10.1001/archpsyc.57.3.209
28. Perroud N, Courtet P, Vincze I, et al. Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt. Genes Brain Behav. 2008;7(3):314–322. PubMed doi:10.1111/j.1601-183X.2007.00354.x
29. Williams RB, Marchuk DA, Siegler IC, et al. Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress. Psychosom Med. 2008;70(1):32–39. PubMed doi:10.1097/PSY.0b013e31815f66c3
30. Tarullo AR, Gunnar MR. Child maltreatment and the developing HPA axis. Horm Behav. 2006;50(4):632–639. PubMed doi:10.1016/j.yhbeh.2006.06.010


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text: I'm starting this thread looking for feedback on what the Rosters add-on should include or not include. As things are falling into place I thought this would be a good time to start this thread. Right now I'm working on the leaders side of things, so far the primary leader can (if the rights are set by the admin): - appoint a second leader - remove a second leader - edit/change a second leaders rights, listed below - change secrecy level - edit secrecy message (teaser) - change join status - send invites - remove members from the roster - edit roster description - edit roster banner Seconds can (if given by an admin, or roster leader): - change secrecy level - edit secrecy message (teaser) - change join status - send invites (default, yes) - remove members from the roster (default, yes) - edit roster description - edit roster banner Notes about leaders: As there is a permission to allow members to freely remove themselves as a member of any roster, if a leader removes themselves from the roster, the second is automatically promoted to leader. If there is no second to promote, the roster is automatically closed to join requests and the secrecy level is set to the highest level. This way if a leader has a falling out with members of his secret guild and decides to get back at them by setting the secrecy level to it's lowest setting and the join-status to open before he leaves, the guild basically goes into lock-down. If there is a forum set up for members of this roster, leaders and seconds do not need to be content moderators. Admins may only want global moderators to handle all moderation duties for all his forums. If Admins want only content moderators to be leaders and seconds, then they should take away the leaders ability to add/remove a second, and make the content moderators of those forums the leader and second. Questions: Should there be more than one secondary leader for a particular roster? If so, how many? Increasing the amount from my side of things is relatively easy with the way it is handled. Are there any more tasks a leader and secondary leader can perform that I haven't thought of? Thanks for any feedback on the leadership side, it is appreciated.


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This Diwali, our photographer was at the Bachchans. He snapped up the stars who arrived for the glitzy do at Jalsa. But what had our attention were the hosts - Aishwarya Rai & Abhishek Bachchan. The two were at hand to personally receive and see off guests. And in between all their social niceties it was nice to see the rapport the two share after six years of marriage. Check it out!
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Walking exercise improves bowel preparation before colonoscopyBMJ 2005; 331 doi: https://doi.org/10.1136/bmj.331.7528.0-e (Published 01 December 2005) Cite this as: BMJ 2005;331:0-e
Research question Can gentle exercise improve the quality of standard bowel preparation before colonoscopy?
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About the Book
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Large Format Landscape, 13×11 in, 33×28 cm
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- Tags architecture photography, Los angeles photography, photo books, linda kasian photography
About the Creator
Happiness isn't something you experience; it's something you remember Oscar Levant Having the ability to write about one self is a talent that I have yet to develop, or at least have a hard time with. Not that I don't have what to say, but after perusing the Internet, Who wants to sound like every other photographer writing about how great and creative one is or about "capturing the essence of the moment" that is so…blah What I can tell you is that I am a passionate person. I am passionate about my family and my son. I am so passionate about them, I try to capture every moment through my lens and freeze those memories we share forever. I am passionate about motorcycles. The faster the better. And I am passionate about my photography, especially when it comes to photographing people. Smiling, laughing, crying, running, jumping, kissing, loving or just breathing in their moment in time together. That is the essence of my passion and photography. More stuff about me
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World-Famous Alinea Popping Up in Miami Beach in February, Tickets on Sale December 2
Alinea's trout: Smoked trout, golden roe, broccoli, fried trout skeletons, and fish sauce caramel.
After months of teasing and planning, Grant Achatz and Nick Kokonas' Michelin three-star Chicago temple of gastronomy will begin serving February 17 at the Faena Hotel Miami Beach (3201 Collins Ave.) within developer Alan Faena's burgeoning arts district.
Tickets will go on sale December 2 at 11 a.m. An 18-course (give or take) menu will "look to the culture, the produce of South America, of everything that's going on in that part of the world and do the Alinea version," Kokonas tells New Times. Reservations will be offered for parties of two, four, or six. The regular menu will go for $275 to $385 per person based on the time of the week. It's the same system Alinea uses at its home base in Chicago. An early Wednesday night dinner, for example, will be cheaper than primetime Saturday night. Seats will be offered Wednesday through Sunday nights from 6 to 10:45 p.m.
Wine pairings will be offered for $150, $275, or $495 per person, with the priciest being plucked from the special wine cellar being built at the Faena.
If this one has you salivating, cue up your browser for December 2 at 11 a.m. Kokonas said they've already received requests from clients all over the world eager to taste what Achatz can pull off in Miami. There have also been requests for restaurants buyouts. Kokonas wouldn't say whether it's any of the hedge funders scooping up Faena's million-dollar condos, but that's where the smart money is going.
The pop-up comes on the heels of Alinea's tenth anniversary when Kokonas and Achatz decided to temporarily shutter the Chicago restaurant to give it a full overhaul. "At some point you turn into your grandparents' living room," Kokonas said. As the restaurant is torn up, all 42 of Alinea's employees will be moved to Madrid for a monthlong pop-up before relocating to Miami for the Faena project.
Another of the world's most iconic restaurant's, Rene Redzepi's Noma in Copenhagen, uprooted itself earlier this year and re-emerged inside Tokyo's Mandarin Oriental.
Back in Miami, it seems we have the white-suited Argentine developer Alan Faena to thank for luring Alinea here. They called Kokonas nearly a year ago hoping to get some sliver of his restaurant's culinary intrigue here for the opening. "They expected me to say there's no way we're going to go and do this in Miami for two days when you could choose Paris or London or New York," Kokonas says.
But when he and Achatz found out they'd be able to take over a nearly untarnished dining room and kitchen, the deal almost sealed itself. "We took a leap of faith," Kokonas said.
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text:
MultiplayerAres. Hades, Zeus or Poseidon. Each allignment offers their own play-style, as wll as abilities within battle.
Players can unlock magic abilities, new weapons and armors, relics, and treasures by collect XP to strength their warrior. The attack-style of the allignment is critical to the warrior's growth path. Matches introduce buffs and debuffs at random points through matches, which can boost a players stats or hinder them.
Players are assigned challenges, labeled as Labors, to complete. These challenges can reward armor and weapons.
There are four primary multiplayer modes in Ascension's multiplayer, Team Favor of the Gods, Match of Champions, Trial of the Gods, and Capture the Flag. These modes all play and handle a bit differently and compliment the game's playstyle in various ways.Trojans and Spartans. Each time attempts to acculate a number of points to clain victory. Points, or Favor, are earned by killing opposing players, capturing altars, collecting red orbs, and setting traps. Match of Champions is a similar game mode to this, except is a free-for-all variant.
Trial of the Gods is a two player, cooperative, time trial mode where players face waves of mythological creatures, followed by a boss fight. There are five waves to plow through, and each wave gets more difficult. Players also need to be aware of the clock, completing the waves within a certain amount of time.
Capture the Flag is an interesting take on the classic game mode. Spartans and Trojans battle it out to steal the opposing team's flag and return it to their base to score. Players holding the flag are restircted on their attack capabilities, but are granted minor healing and stunning abilities. There can also be a neutral flag which can be taken and scored by any team.
To those who have gotten their hands on Ascension, what do you think of the multiplayer? Was it a solid addition to the God of War franchise, or should the game simply follow the exploits of Kratos and nothing more?


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Uirlisí inrochtaineachta
Uirlisí seirbhíse
Roghnóir teanga
Cosán nascleanúna
Additional tools
Please note that news, features and events might only be available in English, French and/or German.
The European Social Network is organising the 19th European Social Services Conference in Warsaw from 6-8 July in partnership with the Polish Presidency of the EU. This year's theme is "Building an Active and Caring Society: Innovation, Participation, Community".
The second Forum on social services of general interest (SSGI) will be held under the French Presidency of the European Union on 28 and 29 October 2008.


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Havildar Education Recruitment 2014-2015
Indian Army has notified an advt. as Havildar Education Recruitment 2014-2015 to fill up Havildar in Group 'X', 'Y'. Job hunters who are searching for Indian Army Jobs, they must apply for Havildar Education Recruitment 2014-2015 on or before 10 August 2014.
Important Date:
|Last date of application receipt
|10 August 2014
Organization name
Indian Army
Name of Post
Havildar Education
Name of Group
- Group X
- Group Y
Qualification Details:
For Group X
Job hunters must possess M.A/ M.Sc/MCA or BA/B.Sc/BCA/B.Sc (IT) with B.Ed from any recognized University/Board.
For Group Y
Applicants need to have B.Sc/BA/BCA/B.Sc (IT) Degree from any recognized university.
Age Limit as on 09 September 2014
Contenders should be between 20 years 25 years of age.
Selection procedure:
Selection will be made on the basis of Physical Fitness Test, Written Test followed by teaching Aptitude Test/Interview.
How to Prepare For Written Exam
How to apply?
Job hunters need to send application form in a prescribed format along with all required documents and two self-addressed envelope duly affixed with Rs 22/- denomination postal stamps issued by the Department of Post & Telegraphs in an envelope superscripted as Application for HAV AEC to below address on or before 10 August 2014.
Army Recruiting Office
Station Road, Old MFD Complex
Visakhapatnam (Andhra Pradesh)
Pin – 530004
Note: Applicants may check official Notification
You may also like to Read


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Into Cerberon is a modification of Doom 3. The project aims to bring the gameplay of the definitive 6-degrees-of-freedom game, Descent, into the industrial gloom. Fly around the interiors of mines, refineries, research centres, and other industro-technical environments with full six degrees of freedom control: roll, tilt, yaw, and slide in all directions. Battle with your friends in pitch-black tunnels in the multiplayer action, or take on robots infected with a terrible nanovirus plague in the singleplayer campaign. An array of powerful weapons are at your command; from the humble lasers (not so humble once upgraded) and mundane concussion misssile to the fantastic Fusion Cannon and tremendous Mega Missile. Awe your foes as electric bolts leap from your ElectroHull, or give new meaning to the phrase "bad sunburn" with the insidious UV-8 Ultraviolet Emitter. Feel the kickback of the powerful AutoCannon as it hammers your target, or the heat from the Flamethrower as it fries armour plate like chicken wings. The game itself describes itself as Descent Remade.
The development of the project started right after the Doom 3 release, making it into a completely unique design different from the actual game itself. It was announced in 2005, with a release a year later with the Alpha, Beta and then a final version in 2007 despite the 0.00 type version.


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Doji Kaneshiro was a courtier of the Crane Clan and a member of the Second Gozoku. He eventually recruited Matsu Mieko, subverting her loyalty to the late Empress Toturi Tsudao into hatred for the new Emperor Toturi III. Kaneshiro asked Mieko only for minor favors, small things that would neither compromise her honor, nor her direct orders from her superiors. [1]
- ↑ Unexpected Allies 2, p. 38
|This Crane Clan related article is a stub. That means that it has been started, but is incomplete. You can help by adding to the information here.


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Firm DescriptionABOUT INNOVATIVE HEARTH PRODUCTS:
IHP manufactures a wide variety of fireplace products under the Astria and Superior brand names. The brands feature aesthetically and technologically advanced indoor and outdoor fireplace systems, comprising energy-efficient solutions for dealers, distributors, designers, architects, and consumers.
Retailers and consumers can visit the Astria website at www.astria.us.com for a comprehensive overview and well-cataloged list of product offerings in distinct selling categories. The Superior brand website, www.superiorfireplaces.us.com, is specifically geared for builders, designers, architects, and remodelers to learn about a diverse range of fireplace and home-heating products for their residential, development, or hospitality design-build projects.
Astria Rhapsody Direct-vent Gas Fireplace
Product Description:
Linear in design and stunningly multifaceted in effect, the Astria Rhapsody Direct-vent Gas Fireplace offers a sophisticated, energy-efficient and easy-to-install heating option for modern offices, hotels and any hospitality or commercial space interior. Its expansive viewing area showcases a continuous band of dramatic, wavering flames that are enhanced by a porcelain interior with illusion panels and backlighting. A choice of finishes adds to the beauty of the fireplace and its long, tall elegant flames.
Product Specifications:
• 51- and 39-inch-wide viewing area creates a breathtaking linear design to complement interior spaces.
• Innovative Infini-Flame™ technology produces a continuous band of tranquil flames across the viewing area.
• Porcelain interior with optional illusion panels and backlighting add design interest even when the fireplace is off.
• Unique burner design with industry-leading energy efficiency delivers outstanding flame height and more visible flame per BTU.
• Heat-circulating design increases warm air distribution for exceptional supplemental heat.
• An optional fan kit helps circulate warm air into a large room for maximum comfort.
• Full function remote control (T'stat, flame, blower, lighting, IPI/CPI).
• Adjustable nailing flanges and a lightweight design allow for flush wall mounting and quick, easy installation.
• Unique floor designs feature reflective panels or glass media options.
• Optional surround and bezel accessories allow for customization to interior styles.


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Is Paediatric Research an Ethical Dilemma?
Lindahl, Sten G. E.
Bibliographic Citation
Paediatric Anaesthesia 1999 November; 9(6): 473-474
MetadataShow full item record
Related items
Showing items related by title, author, creator and subject.
Consent in Paediatric Research: An Evaluation of the Guidance Provided in the 2007 NHMRC National Statement on Ethical Conduct in Human Research Spriggs, Merle P.; Gillam, Lynn H. (2008-03-17)
A Classification of Clinical Paediatric Research With Analysis of Related Ethical Themes Pearn, John (1987-03)Different types of clinical research are associated with different degrees of risk and with varying utility. Usually classified as therapeutic or non-therapeutic, clinical research involving children necessitates a balance ...


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Wall of Bones was a fortification built by lost Kaiu engineers by order of Daigotsu. It was designed to defend the Lost from the incursions of the Hiruma. Construction on the great wall started in 1158. [1]
Defensive Sructure Edit
Daigotsu's wall was formed of the bones of both his failed servants and the corpses of his enemies. It had four towers, and a single gate was its only point of entry, centered to the only path which led directly to the City of the Lost. [2]
Notable Locations Edit
- Supply Tower - North Tower
Destruction Edit
In 1171 the Wall of Bones was destroyed when hundreds of creatures were driven out of the depths of the Shadowlands, by something dangerous enough to scare oni. The demons were dying under the hooves of the larger creatures, but these oni were simply running away. The Kaiu Wall began to suffer daily attacks from the fleeing demons. [3]
External Links Edit
- Wall of Bones (Spirit Wars)
- ↑ Bloodties, A Tale of Rokugan, by Rich Wulf
- ↑ Secrets of the Shadowlands, p. 84
- ↑ A Warrior's Peace, by Brian Yoon
|This Shadowlands related article is a stub. That means that it has been started, but is incomplete. You can help by adding to the information here.


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December Planting: Southwest Gardening - Edible Gardening ...
If you love to grow your own vegetables from seed, December is the time to get them started in the Southwest. Learn tips on December planting, from Miraclegro.com.
Spring Vegetables to Grow in the Southwest - Edible ...
Explore what vegetables to grow in the spring if you live in the southwest. Learn about timing your vegetable garden, what to grow and how to care for it.
Planting Trees: Where & Why - Trees, Shrubs & Landscaping ...
Read this article on the many benefits planting trees. Read where you should grow trees and why, on Miraclegro.com.
Mums, Pansies & More: Late Summer & Fall Flowers - Flower ...
Learn more about late summer & fall flowers from Miraclegro.com. For example, what are the best fall flowers to brighten up the yard after a long & hot summer.
Gardening with Cactus: Colors and Shapes - Flower & ...
Find out how cactus can beautify your desert landscape. Learn more about these must-have plants for your desert garden. See how cactus add texture and color at miraclegro.com.
Growing Agave Plants for Beauty & Easy Care - Miracle-Gro
How to find out about growing agave, how an easy and low-maintenance plant adds color and texture to your landscape. Learn how to grow agave from miraclegro.com
Growing Desert Mallows - Globemallow Flowers - Miracle-Gro
Check out our guide to growing globemallow flowers in your desert garden. Learn where and how to grow globemallow flowers and how to care for them.
Xeriscaping: Guide to Water-Friendly Gardening - Miracle-Gro
Discover Xeriscaping, gardening with native plants and techniques that minimize water usage. See how you can grow beautiful drought-resistant plants even in severely dry areas
Creosote Bush Spring Flowers & Easy Care - Flowers & ...
See how creosote flower bring color and life to a landscape. Grow a low-maintenance, colorful drought tolerant shrub. Learn tips for landscaping from MiracleGro.com
Planting Ocotillo in Your Garden - Miracle-Gro
Learn how to plant ocotillo in your garden. Get advice and tips on the benefits of ocotillo and how to plant this colorful desert native flower.
Fruit, Vegetable & Herb - Learn and Grow
Miracle-Gro offers a series of landscaping articles going deeper into flower concepts for smaller garden spaces.
Garden Protection from Drought - Gardening Basics - Miracle ...
Explore easy ways to protect your garden from drought. Find tips on soil, mulch, watering techniques & more on miracle.gro.com
Edible Gardening - Learn and Grow
All about eating what you grow
When Is The Best Time To Plant Trees ? - Miracle-Gro
Learn how to select, plant, and maintain the right trees or shrubs for your yard and your climate. Read more on Miraclegro.com.
How to Attract Hummingbirds: The Right Plants & Settings ...
Find out about tips for attracting hummingbirds to your garden. Provide these alluring traits in your garden and hummingbirds would be flying in your garden.
How to Grow Basil | Miracle-Gro
Learn how to grow tasty basil
Garden Planning - Learn and Grow
Dreaming BIG? Start here...
Growing Zucchini | Miracle-Gro
Why buy zucchini when a package of seeds or just a few plants will yield a bountiful harvest with plenty to share? Learn how to grow zucchini at home.
How to Grow Pumpkins - Edible Gardening - Miracle Gro
Find out how to grow the biggest pumpkin on your block. Ensure you are taking the right steps before and after planting the pumpkin seeds.
Miracle-Gro Water Soluble Rose Plant Food - Plant Food ...
Find great plant care from Miracle-Gro. Learn more about Miracle-Gro Water Soluble Rose Plant Food & get product usage details on Miracle-Gro.com


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The iShares MSCI Brazil ETF ( EWZ) is the largest non-U.S., single-country ETF, with about $10.5 billion in assets under management as of this writing -- up $1 billion in about a year's time and growing all the time. The fund covers mostly large-caps and Brazil's biggest-name brands, and it is a great way to give investors exposure to the booming market. Its popularity speaks of how highly Wall Street thinks of Brazil. And if you're a super Brazil Bull, there's even a leveraged ETF just for Brazil, the ProShares Ultra MSCI Brazil Fund ( UBR) that seeks to deliver 200% of the daily performance of the MSCI Brazil Index -- but obviously this is a much more aggressive play.
Also see: Take beverage giant Companhia de Bebidas das Americas ( ABV), or Ambev for short. This beverage giant is a consumer staples stock that in America would normally be considered a sleepy play that is conservative and recession-proof but not altogether sexy. Yet Ambev boasts explosive growth potential. Its second-quarter net profit leaped 20% according to ABV earnings a few weeks ago. And share prices are up more than 7% so far in 2011 and over 50% in the past 12 months -- compared with a slight loss for the Dow since January and only 11% gains in the past 12 months. 6 Cheap Tech Stocks That You Should Avoid Also see: Although other consumer staples stocks like Coca-Cola ( KO) also have outperformed the market -- a slight gain in 2011 and about 20% returns in the last year -- they still are well behind the "sleepy" staples stocks of Brazil. The Colonel Invades Kenya - KFC Opens in East Africa Jeff Reeves is editor of InvestorPlace.com. As of this writing, he did not own a position in any of the stocks named here. Follow him on Twitter via @JeffReevesIP and become a fan of InvestorPlace on Facebook.


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I get out at least daily to bike, boat or whatever. In Boston I rowed three times a week, looking to start that here, and am an avid horse rider. The rest of my trail activity is pedal-powered - I love zipping around this city and the regional bike trails.
**Update July 31, 2016 - Just completed my Open Dive certification. Anyone want to go diving?
Adore exploring both in and out of the city. I enjoy festivals and farmers markets, and love live music (no rap, not really into metal , hard rock or dj/techno except for very rare occasions. I'm a fan of the performing arts, museums and visiting natural and historical sites on day/weekend trips. Also an avid cook and love all types of travel (local, regional, international by car, plane, train or boat - camping all the way up to a five star hotel).
I can be whimsical, practical, passionate about many things, with a dose of out of the box approach - I am cerebral and intuitive...and appreciate the cerebral/whimsy/passionate/out of the box counterpart.
Update: 12:45 am 9/29/2013
On the ferry from Newfoundland after a week of traveling this incredible, rugged province solo. Had an amazing time, but would love to find a partner for some of these adventures!
Creative cooking (using recipes as a guide).
Figuring things out and calling it like I see it.
Chocolate chip cookies - No, seriously, you have no idea.
Finding and appreciating kindred spirits.
High level planning, crisis management and spontaneous exploration.
Movies - again eclectic - Shawshank Redemtion, Avatar, The Legend of Bagger Vance, The Grand Budapest Hotel, Salmon Fishing in Yemen, The Man From Snowy River, Chick flicks, Dramas, Historical Fiction, Food films. Have been known to watch the Lethal Weapons series and love a good, "come from behind" underdog wins sports movie, etc.....
NPR and CBC radio - love a good driveway moment!!!
I keep up with news and current events. Actually, I'm a bit of a news junkie. I read multiple news sites every day and am politically aware but not politically active (I don't get into campaigns or party activities or anything like that).
I appreciate local, organic, sustainably produced food. It is a big part of my work in sustainability and I enjoy hunting for the excellent local suppliers growing my own when possible and doing some foraging. I'm particular about where I eat -- chef-owned restaurants are a favorite, as well as the local dive gems. Any place that takes good food seriously and makes their menu their own....
Adventures - Exploring
Good friends - good conversations
Mountain vistas and incredible sunsets
Wild water -lakes,streams, rivers and oceans
OK - I do like good sex, why not be open about it? But, I don't sleep around. Find I most enjoy it when there's a connection or chemistry, so one night stands are rarely worth it.
I like to sing during road trips, and sometimes in the shower.
How's that for opposite ends of the spectrum?
The other stuff - you'll have to figure out later....
You are passionate about something in your life - training for a race or challenge, the work you do....I'm realizing that I'm best matched with someone who's passion can match my own.
I'd love to hear from you if you are interested in chatting, a fun activity partner, seeing what's possible in this wide-wide world, or if anything I wrote resonates with you. Or.....
Don't bother reaching out if: 1) you haven't filled out your profile or provide a photo it screams laziness or lack of sincerity. 2) Smokers are a non-starter for me. 3) You list God or Bible as one of the six things you couldn't do without - no problem if your Christian, I respect your religion, but we're not a match if its so important to you that its that prominent in your profile. 4)Also, not interested in hearing from 20-somethings (sorry - I like you, but I've also managed you in a professional setting, and appreciate the perspective of a man close to my age or older than me). Really - you won't sway me on either of the two points and you will not receive a response from me.
Finally - a note on bots. I get a lot of spam or maybe real guys who have poor communication skills so here are some tips on how you'll get tagged as a bot or troll: 1) Salutations such as "hey pretty", Hello dear". 2) Using all lower case, or poor/non-existent punctuation. 3) Generic cut and paste, or single to three word messages. 4) focusing only on my photos - I provide a great deal of information in my profile for a purpose. 5) Including the term "god-fearing". 6) Having an empty, sparse or overly general profile. 7) Using the phrase "I'm (insert any name) by name". 8) Immediately sharing your personal contact information. 9) Giving your location in your message, or really any information that's clearly listed in your profile information, and also adding USA or United States when listing your location.
Good luck everyone!


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Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
This study is currently recruiting participants.
Verified February 2017 by Eric L. Greidinger, University of Miami
University of Miami
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by (Responsible Party):
Eric L. Greidinger, University of Miami
ClinicalTrials.gov Identifier:
First received: December 19, 2007
Last updated: February 22, 2017
Last verified: February 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is currently recruiting participants.
|Estimated Study Completion Date:
|July 2017
|Estimated Primary Completion Date:
|July 2017 (Final data collection date for primary outcome measure)


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The Touch of the Master's Hand (9 of 10) by Stan Coffey
This content is part of a series.The Touch of the Master's Hand (9 of 10)
Series: A Mighty Savior
Stan Coffey
Luke 5:12-14
I want to continue a series of messages that we have been preaching entitled "A Mighty Savior." I want you to turn to Luke 5: 12 as we read from God's Word about "the Touch of the Master's Hand." We have a mighty Savior. Our church is built upon the belief and conviction that He is still a mighty Savior today. He hasn't lost His power, hasn't changed His compassion. Jesus is still reaching out, He is still changing lives today. He is still giving hope to the hopeless; He is still bringing comfort to burdened hearts today. And that is what Jesus wants to do in this service today. Not that you just hear a message, but that Jesus would minister to your heart and to your life today through His Word.
Now as we look at this story, the very first thing that I want you to see is the condition of the sinner. Because in the Bible leprosy is always symbolic of the disease of sin, leprosy was a terrible, terrible disease. And here is a man who is full of disease. It wasn't that he just had a light case of leprosy or a spot of leprosy, but verse 12 says he was full of leprosy. Leprosy was coming to a concluding stage and the only alternative was either a miracle of God or death. And this man had gone through the horrible stages of the progressive disease of leprosy.
Leprosy is like sin because leprosy begins small and then spreads all throughout the body. Sin begins small. It may be just a little flirtation but it may lead to adultery and to the destruction of a marriage. It may be in your life just a social drink, but it may lead to alcoholism and the destruction of your home and your family. It may be some sin no one knows about, a private sin, secret sin, that you think is covered and you say it really doesn't make any difference, but sin is like leprosy because it will invade more and more and more of your life. And h ...
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Judy Rodgers of San Francisco's legendary Zuni Café shares a homey, modern holiday menu that includes an interesting stuffing and a turkey roasting technique designed to free up precious oven space.
Smoked Prosciutto & Fuyu Persimmons with
Balsamic Vinegar & Extra-Virgin Olive Oil
Roast Turkey
Bread Salad
Hashed Sweet Potatoes
Wilted Escarole
Open-Faced Pear Tart
All recipes except the roast turkey are from The Zuni Café© Cookbook: A Compendium of Recipes and Cooking Lessons from San Francisco's Beloved Restaurant by Judy Rodgers (W. W. Norton, 2002). Copyright 2002 by Judy Rodgers.


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Adelman wins No. 800 as Rockets continue to rollMar 25, 2008 - 6:00 AM By Gene Duffey PA SportsTicker Contributing Writer
HOUSTON (Ticker) -- Rick Adelman won his 800th game as the Houston Rockets stayed in the hunt for the top spot in the Western Conference.
Rafer Alston scored 28 points and Tracy McGrady came alive in the fourth quarter to help the Rockets put away the Adelman's former team, the Sacramento Kings, 108-100, on Monday night.
Houston (48-23), which had its 22-game winning streak snapped last Tuesday, is just one game behind the Los Angeles Lakers (49-22) for first place in the competitive Western Conference.
"It feels like 800," said Adelman, looking a little worn out after the game that wasn't decided until the final 70 seconds. "When you get something like that, you think about all the great things that have happened to you. It's very gratifying."
Adelman won most of the games coaching Portland for six years and Sacramento for eight.
"I had two great situations before this," said Adelman, who also coached Golden State for two years, the only two seasons he didn't reach the playoffs in 16 campaigns. "A lot of guys in this league don't get a chance to coach even one good team."
"That's great for him," said Sacramento forward Ron Artest, who scored 17 points. "He turned my career around. I hope he coaches for a long time and goes to the Hall of Fame."
McGrady was sorry to see former Houston coach Jeff Van Gundy go after last season, but he was happy that Adelman was the man to replace him.
"It's his personality, really laid back, understanding the players, giving the players their confidence," McGrady said. "One thing I really admire about coach is his rotation and his ability to put guys out there in the right situation. He gives young guys the opportunity to go out there in the right situation and succeed."
McGrady twisted his left ankle with 7:42 left in the first quarter. He stayed in the game, but Alston had to pick up his offense.
"In the first half, it took a while to run it off," McGrady said of the ankle. "The second half it was fine."
McGrady scored nine points on 2-of-12 shooting through the three quarters, which ended with Houston on top 77-72. But he scored eight points in the decisive fourth quarter, making 3-of-4 shots.
"It was a close game," McGrady explained. "I had missed some easy shots. The fourth quarter I want to assert myself."
McGrady said the ankle was fine after the game, but he did have an ice bag taped to his left shoulder. He said he sprained that late in the game running into a pick.
Alston played consistently throughout, shooting 9-of-17 from the field, including 3-of-6 from outside the arc, and 7-of-8 from the line. He added five assists without a turnover in 39 minutes.
"Rafer was good all night," Adelman said.
"Tonight we went to the line, made some free throws, more than we have been making down the stretch, and got the victory," said Alston, whose team made 33-of-42 foul shots. "Being a point guard, I've always believed in going to the line late (in a game)."
"He had a very nice game and has played extremely well all season," Sacramento coach Reggie Theus said of Alston. "He's been solid, and that's why Houston is where they are now."
Sacramento didn't make it easy on Houston.
The Kings last led 30-29 early in the second quarter but stayed in the game until the final minute. Sacramento closed within 91-89 on Artest's drive with 4:13 to play.
"It was tough to overcome their free-throw shooting," Theus said. "We had some runs, but then they went to the free-throw line, and it was a rally killer."
Kevin Martin scored 18 points in just 31 minutes due to foul trouble and fouled out with 33 seconds to play for Sacramento.
Reserve forward Chuck Hayes gave the Rockets a lift, scoring a season-high 10 points to go with seven rebounds, four assists and some good defense on Artest.
"Chuck was tremendous," Adelman said. "He guarded Ron, and he's a tough cover. He made his free throws, he made big plays and got big rebounds."
"He's a load," Hayes said of trying to contend with Artest. "There's no way rooting him out his position. He's strong. I told myself, 'Don't foul him.'"
Hayes, who has a hesitation in his foul shot that often draws lane violations from opponents, made 4-of-5 free throws.
"It's not orthodox, it's not the prettiest thing," Hayes said of his foul shot. "Everybody in the world has tried to change it. But I've been doing it for a long while."
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Kings 100, Rockets 108 FinalMar 25 3:14 AM
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Kings 97, Rockets 103 4th - 0:44Mar 24 10:56 PM
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Kings 89, Rockets 95 4th - 3:00Mar 24 10:45 PM
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Kings vs. RocketsMar 24 1:50 AM
Related News
- Towns, Porzingis unanimously selected to All-Rookie 1st team May 19
- NBA China to open basketball-themed Playzone in Shanghai May 17
- Kings' methodical coaching search ended with Dave Joerger May 10
- Kings hire coach Dave Joerger 2 days after firing in Memphis May 9
- A person with knowledge of the deal tells The Associated Press the Sacramento Kings have agreed to terms with Dave Joerger on a three-year deal to make him their new coach May 9
- Rockets must find coach in wake of first-round ouster Apr 29
- Kings hire Catanella as assistant general manager Apr 28
- Warriors reach second round with MVP Stephen Curry sidelined Apr 28
- Warriors roll into second round of playoffs without Curry Apr 28
- Warriors look to advance, Clippers, Heat aim for home wins Apr 27
- Rockets-Warriors Preview Apr 26
- Warriors look to advance, Clippers, Heat aim for home wins Apr 26


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Register To Attempt Complete Test
Create Account
Read the passage below and solve the questions based on it.
In a survey of 500 students, it was found that 255 play table tennis, 195 play lawn tennis, 115 play tennis, 45 play table tennis and tennis, 70 play table tennis and lawn tennis, 50 play lawn tennis and tennis. There are 80 students who do not play any of the three games.
What is the number of students who play all the three games?


text:
The Sony Ericsson C905 mobile phone was the first 8MP camera mobile phone with a Xenon flash. Built-in Wi-Fi and 3G connectivity speeds up data transfer. Other features include built-in GPS with Google Maps, Geo-Tagging, TrackID and the Accelerometer sensor for auto-rotating of your screen. The average monthly bill is just £27.22.
Clickhere for Sony Ericsson C905 from E2Save deal
[Wait until window loads then scroll down to deal]
Look and feel
The C905 is on the chunky side, partly due to its slider format.
Ease of use
The camera can be fired up by sliding open a protective lens shield found on the back of the device.
With on-board GPS, you can also geo-tag your pictures so you can refer back to the location in which you took the shot.
Locating a GPS fix proved tricky and tiresome.
Battery life
The C905 has a decent battery life.
Click for full review