text:
Möchtest du als deine Standardwährung festlegen oder nur für diese Sitzung behalten?
Roxy the housekeeper and Dan , not sure of his title . Really added a nice touch to the stay. Very personable and full of laughs. These two definitely added to my stay
The hotel location was good for where I need to go on this trip to Deadwood. I would of liked a fridge in my room. When traveling on business I like to have that for my water, juices and food items that need refrigeration. It was not a deal breaker though. I would book a room again here.
Clean rooms. We faced a patio area but it was quiet at night. Nice to bring our dog with us- the pet rooms had tiled floors The breakfast buffet is ok but not great food. The dog run was gross- nobody cleaned up after their dog. Not an attractive setting but good for a stop over for a night
Hidden fees. Poor quality bed and pillows.
clean comfortable rooms, free soda and coffee, nice gaming selection, the girls climbing on the fabric into the ceiling was entertaining, not too sexy, but a lot of work for them. They were breathing heavy when they got done with their flips. Nice check in and out, good gamers club, free drinks while gambling, free premium drinks when in the dollar games. All was good
My fiance and I loved it the room was nice the accomadations were nice we accidentallyreserved wrong night but the customer service person we spoke with fixed and we enjoyed so much we stayed another night Nothing loved all of it


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Cholesterol Drugs
March 1, 2012 by staff
Cholesterol Drugs, Federal health officials are adding new safety warnings about risks of memory loss and elevated blood sugar to statins, a widely prescribed group of cholesterol-lowering medications.
The Food and Drug Administration said Tuesday it is making labeling changes to medicines like Pfizer's Lipitor, AstraZeneca's Crestor and Merck & Co. Inc.'s Zocor. The drugs are used by tens of millions of U.S. patients to help prevent heart related problems associated with cholesterol.
New labeling on all such drugs will warn of memory loss and confusion reported among certain patients taking statins. The problems were generally not serious and went away after patients stopped taking the drugs, according to the FDA.
The updated labels will also mention elevated levels of blood sugar, associated with diabetes, that have been reported in some patients taking statins. A growing number of studies published over the last five years have found a link between statin use and type 2 diabetes. Last June, a report in the Journal of the American Medical Associationanlyzed five older randomized trials and concluded the increased risk was small but real for people taking higher doses of any statin.
Statins are mainly prescribed to prevent heart attacks in people with clogged arteries and work by dramatically lowering LDL or "bad cholesterol." They were the third best-selling drug class in the U.S. for 2010 with sales of $18.8 billion.
In addition to the label additions, the FDA said it will remove a long-standing warning related to liver injury. The drugs label previously recommended routine testing of liver enzymes to avoid injury. The agency now recommends a single test when patients first begin taking statins.
"FDA has concluded that serious liver injury with statins is rare and unpredictable in individual patients, and that routine periodic monitoring of liver enzymes does not appear to be effective in detecting or preventing this rare side effect," the agency said in a statement.
Please feel free to send if you have any questions regarding this post , you can contact on
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text: NFL Week 6 Betting Digest at Sportsbook Review network By SBR Sunday, October 18, 2015 Share with: Sportsbook Review has released this week's NFL Week 6 Betting Digest. Listed below are all resources available for sports bettors to assist with their handicapping and maximize profits with online sportsbooks headed into this Sunday. NFL Week 6 Picks An ATS betting list for Week 6 NFL has been posted at SBR Picks. Predictions on each game are listed along with the recommended sportsbook odds associated with each selection. SBR Picks are available for free. NFL Week 6 Betting Odds Sports bettors can compare betting odds for NFL week 6 from 34 online sportsbooks using SBR Odds. In addition to the outright odds, players can access the latest injury and match up news, plus consensus betting information, and a history of line movements for each online sportsbook featured. Week 6 NFL Prop Bets & Super Bowl Futures Week 6 NFL prop bets are displayed from the top online sportsbooks. The betting sites who have their odds displayed are also featured in the best sportsbooks list and are in good standing with players. NFL Betting Forum Sportsbook Review invites users to participate in the NFL Betting Forum where handicapping ideas are passed around like one dollar bills in gentleman's clubs. A discussion that is presently trending is Geno's Picks for NFL Week 6. NFL Sportsbook Bonuses The sportsbook bonuses list compares sign up bonus offers from online sportsbooks rated from C to A+. SBR Tools: Betting Calculators SBR offers the biggest variety of free betting odds calculators on the market. From the Kelly Criterion calculator to the conventional parlay odds calculator used to determine if your next move should be to hedge or let it ride, there's a calculator from bettors of all levels of experience.


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|Property type
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Beautiful, first floor condo in a gated spa-like environment in exciting Nuevo Vallarta, Mexico. Located near other restaurants, Vallarta tours for scenic trips; riding with the dolphins, among other adventures..
This condo is newly painted and most furniture recovered to reflect the charming ambiance of the Mexican culture. Fully equipped Kitchen with high end appliances including: stove top, oven, microwave, washer, refrigerator, freezer by Bosch as well as dishes and glasses, kitchen utensils and silverware. Dining table with 6 chairs. Three bar stools for sitting at the kitchen island or counter in the living-room.
There is an iron and ironing board. Both bathrooms have their own hair-dryers and soaps.
Sleeps 6- 1 King, 1 Queens, 2 Full size singles in living-room. Extremely comfortable beds. Sheets and towels are included. Newly installed Air conditioners in both bedrooms and living area. Outdoor patio where you you can step into your own private pool. Large patio table with 6 chairs overlooking the pool and an additional patio for sitting outside by the pool. Private pool is located on a lagoon, with bamboo and other local foliage providing privacy through nature.
Two flat screen TVs are available; one in the master bedroom and the other in the living-room. There is also copious storage space.
Water and internet available. Rental includes all utilities with the exception of electricity that will be metered.
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Owner belongs to the Paradise Village Club which includes:
1. El Tigre Golf Course
2. A Marina Ocean Beach Club
3. Several Pools & Restaurants.
4. Spa facilities available
5. Sports/ Exercise facility with its own large pool
6. tennis courts, bocci
7. hot tub, sauna.
House Rules: -Electricity is not included in rental price.
-You will be staying in a newly renovated home. Please be thoughtful about the property and treat it as you would your own home. Please be mindful that neighbors are nearby, so no loud music or noise before 9AM or after 9PM. Kindly remove any trash or food when leaving and return all cards/keys. We hope you enjoy your stay and leave refreshed and relaxed.


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Purchase Tickets | Parking Advisory
BOSTON - Seeking its fifth victory in six games, the Boston University men's basketball team hosts Ivy League member Cornell on Saturday with tip-off set for 1 p.m. The Terriers (4-6) and Big Red (4-7) are meeting for the third straight season.
The lone team in the America East to feature five men averaging eight or more points a game, BU is led offensively by junior D.J. Irving. Averaging a team-high 14.6 ppg, the 2012 All-Conference Second Team honoree has scored 20 or more points on three occasions and just needs 15 more assists to claim sole possession of 10th place in the school's career record book.
Second in scoring at 11.2 ppg, junior Dom Morris has played a crucial role in the team's recent success. Over the last five games, he's averaging 12.6 ppg while shooting a stifling 59.1 percent from the field. Other players have also made important contributions.
Hitting the 3-pointer to send the Quinnipiac game to overtime, freshman John Papale finished with a game-high 16 points. Both he and juniorTravis Robinson are combining for 4.8 treys over the last five games while shooting 51.1 percent from behind the arc. Freshman Maurice Watson Jr. is averaging 10.4 ppg on the season but more importantly has shot 52.1 percent from the field over the last five games after starting the year at 37.8 percent.
The team's defensive play has also been key with the program forcing opponents into 18.2 turnovers per game over the last five contests. One key differential from the season-opening five-game losing streak has been the emphasis on staying disciplined while defending the ball. Opponents averaged 22.8 trips to the line during BU's losing streak but since then are only making 14.4 trips.
The Terriers will need to maintain that composure against a Cornell squad that is shooting 73.6 percent at the charity stripe. Shonn Miller leads Cornell in scoring at 10.6 ppg and rebounding at 8.0 rpg. A force on both sides of the court, he is also averaging two blocks and two steals a game. Nolan Cressler is second at 8.1 ppg on a team averaging 62.4 ppg.
Owning wins over Colgate Longwood, Presbyterian and Western Michigan, the Big Red has lost seven games this season. Four of them though came on the road against major conference opponents, including No. 1 Duke and defending SEC champion Vanderbilt. Two of the other defeats were by four points at defending A-10 champion St. Bonaventure and St. Peter's.
Cornell has a 2-1 all-time record in the series with the last two games decided by six points or less. Two years ago at Case Gym, Darryl Partin ('12) scored 30 of his 32 points in the second half to help BU claim a 66-60 victory over the Big Red. Last year, BU missed a game-tying 3-pointer with 44 seconds remaining. Cornell then went 7-of-8 at the line to finish ahead, 71-66.
Following Saturday's game, BU will next head south for the UCF Holiday Tournament in Orlando, Fla., on Dec. 28-29.
The Last Meeting
|Boston University
November 20, 2011
Ithaca, N.Y.
Ithaca, N.Y.
|Cornell Outlasts Men's Basketball, 71-66
Despite senior Darryl Partin recording a game-high 29 points and sophomore Dom Morris hauling in a career-high 14 rebounds, the Boston University men's basketball team dropped a 71-66 decision at Cornell Sunday afternoon.


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Author Tags: Doukhobors, Journalism, Politics, Women
Born in Vegreville, Alberta, Simma Holt is a former Liberal MP for Vancouver-Kingsway and Vancouver Sun newspaperwoman whose cynically packaged Terror in the Name of God (M&S 1964) encouraged intolerance of B.C. Doukhobors. The paperback cover of Holt's book featured a colour photograph of a large, naked woman standing outside a burning building. It excluded the interior subtitle 'The Story of the Sons of Freedom Doukhobors'. This omission enhanced the misconception that all Doukhobors were unruly nudists and troublemakers. Dedicated to the RCMP's Special D Squad that was investigating the Doukhobors during the period when Sons of Freedom radicals were engaging in arson to express their disdain for materialism, Terror in the Name of God was a catalyst for George Woodcock and Ivan Avakumovic to write their in-depth history of the pacifist sect.
Other books by Simma Holt are Sex and the Teen Age Revolution, The Devil's Butler (Random House, 1972) -- about the abduction of a young boy by the Satan's Angels motorcycle club -- and The Other Mrs. Diefenbaker (1982), a biography which reveals the private life of John Diefenbaker's wife. Born in 1922, Simma Holt graduated from University of Manitoba and joined the Vancouver Sun in 1944. After 30 years of journalism, she was elected as a Liberal MP for one term (1974-1979) and served on the National Parole Board. Inducted into the Canadian News Hall of Fame in 1996, she received the Order of Canada in 1997. The Leon and Simma Holt Arts and Science scholarship has been offered annually at Langara College in Vancouver.
Simma Holt also published Memoirs of a Loose Cannon (Seraphim Editions 2008) launched on November 25, 2008 at the Vancouver Lawn Tennis & Badminton Club.
[BCBW 2008) "Doukhobors" "Politics" "Women" "Journalism"


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On April 12, 2014 the HackensackUMC Foundation proudly dedicated the Debra Simon Center for Integrative Medicine at the HackensackUMC Fitness & Wellness Center in Maywood during an emotional ceremony, which honored the life of Debra Simon (formerly of Saddle River, NJ) who passed away in 2009.
"We are incredibly grateful to the family of Debra Simon. Through their donation, thousands of our patients' lives
will be improved," said Robert C. Garrett, president and chief executive officer of Hackensack University Health Network. "This pavilion truly reflects our commitment to treatment of the entire patient --- both physically and mentally. Although time cannot heal her family's loss, Debra's name will live on through this meaningful and important project."
The family of Debra Simon partnered with the HackensackUMC Foundation to see the center through to its completion. The process began four years ago, after Debra Simon committed suicide following a battle with depression. At the time of her death, Debra was living in southern California.
"My mom always shared the importance of supporting your local community through charitable efforts," said Lauren Wright, daughter of Debra Simon. "After she died, I started to think about how her legacy could live on. This began the partnership with HackensackUMC. If we are able to help just one person struggling with any facet of their life, especially depression, then we have done our job."
Through the Debra Simon Center for Integrative Medicine, the Department of Psychiatry & Behavioral Medicine at HackensackUMC has been able to expand its psychotherapy program, including the addition of four psychotherapists. The overall goal of the program is to reduce the unnecessary use of psychiatric medications and strengthen the psychotherapy division to better serve the needs of patients.
"Being located at the Debra Simon Center for Integrative Medicine not only helps us address the whole person (mind, body, spirit) but also allows us to reduce the stigma of mental illness," said Diego Coira, M.D., chairman, Department of Psychiatry & Behavioral Medicine, HackensackUMC. "In the spirit of wellness, any individual can step into our beautiful facility and see their primary care physician, their behavioral health practitioner and/or go to the gym and exercise."
Lauren worked with Dr. Coira on the concept behind the Debra Simon Center, which would carry on her mother's legacy of helping others and at the same time, help people struggling with behavioral issues.
In addition to behavioral health services, the Debra Simon Center for Integrative Medicine includes the MOLLY Diabetes Education/Management Center for Adults and Children, physical therapy, a women's health center with mammography and bone density screening, and a large community health education area with a demonstration cooking studio.
"Hackensack University Medical Center is one of the best hospitals in the nation and it happens to be in our own backyard," said Lauren Wright. "I thought it was a perfect fit. And, specifically, I wanted to support the psychiatry department in hopes of continuing the great therapy work that Dr. Coira and his team do on a daily basis. My hope is to ultimately prevent another family from having to go through what my family has had to endure from the loss of suicide."
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28 Days to Better Landing Pages – Day #22: Proper Use Of Testimonials
TIP: Make sure you are not only using testimonials, but have them positioned properly on the page as well.
I often see two scenarios when consulting on landing pages:
1. Very scarce or non-existent testimonials on a page, especially when it's absolutely necessary for a product or service to have one. Some industries off the top of my head are landing pages for realtors, restaurants, mechanics, beauticians – anything that you can think of that relies heavy on word of mouth of continued patrons.
2. Misuse of testimonials on landing pages. Make sure you don't lump all your testimonials at the end of your landing page or in the side navigation. Place them appropriately on the page commensurate with a given feature or benefit. Also, remember to include your conversion goals (button or phone numbers) after each testimonial. With each testimonial (consumer touches) you increase emotions and build trust.
Testimonials on landing pages are very powerful tools because users are in the "buy-mode" and have found a solution to a need or want. Also try using video in some of your testimonials and watch conversions soar.


text:
The school was used as a high school until 1965 when it became a junior high school for Mount Pleasant Borough and Donegal students. Ramsay Elementary served as a middle school during the 1973-1974 school year and a facility for grades four through eight during the 1974-1975 school year. The following year, Ramsay became an elementary school when the junior high was added to the high school. In the 1993-1994 school year, Ramsay became a grade three through grade six elementary building. In the 2009-2010 school year, Ramsay became a grade two through six elementary building.
Several classrooms, a music room, art room, library, and state of the art technological capabilities have been added to the original building complex. The building currently houses grades two through six and accommodates approximately 350 students.


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- (2014-10-03) Setting Trip Point on Switchless Wah by Morley
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by Jean Philippe
Order now to get it by: Monday August 14 - Wednesday August 16
This product ships with limited tracking information, and may take longer than usual to be delivered.
Condition: New
Product ID: 700687
Delivery Information |Returns & Exchanges |Payment Methods
Launched by the design house of Jean Philippe in 1975, CHAZ is a men's fragrance that possesses a blend of lavender and
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Men must learn how to be good listeners, dating expert saysPosted on: October 19, 2012 11:53:50
Single men stand more chance of finding a new partner if they hone their conversation skills, according to dating expert Carlos Xuma.
First dates can often be awkward, especially if you suddenly discover that you have very little in common with the lady on the other side of the restaurant table.
However, Mr Xuma believes that there is a certain way to talk to girls and being able to listen is absolutely crucial.
"Few people realise that the best way to be a scintillating conversationalist is to be a good listener," he remarked.
Mr Xuma insisted that your date will be hugely impressed if you devote 100 per cent of your attention to what they are saying, so whatever you do, don't sit there flicking through your phone while she is pouring her heart out.
Another thing that quickly turns the ladies off is being too cocky, the dating expert recently stated.
Having high self-esteem is great, but remember, there is a fine line between confidence and arrogance.
Tired of being single? Try online dating!
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Hong Kong Phil boss "dreams of working with Jackie Chan"Posted on: April 17, 2014 16:26:26
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Lee Ryan and Casey Batchelor steam up the CBB housePosted on: January 6, 2014 17:25:01
They may have been shackled together when they entered the house but Lee Ryan and Casey Batchelor have done anything but drift apart since they were set free In fact...
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The online dating racePosted on: January 6, 2014 16:22:05
New research has revealed how likely single people are to get a message from an online dating site throughout According to MailOnline age matters more to men than women as...
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When Danielle Cornwall-Nash appeared on ITV s prime time dating show Take Me Out last year she hoped that she would find a new partner and maybe even a new...
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text:
Improved Functional Activity of Bone Marrow Derived Circulating Progenitor Cells After Intra Coronary Freshly Isolated Bone Marrow Cells Transplantation in Patients with Ischemic Heart Disease
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There is growing evidence that intracoronary autologous bone marrow cells transplantation (BMCs-Tx) in patients with chronic myocardial infarction beneficially affects postinfarction remodelling. In this randomized controlled study we analyzed the influence of intracoronary autologous freshly isolated bone marrow cells transplantation by use of point of care system on cardiac function and on the functional activity of bone marrow derived circulating progenitor cells (BM-CPCs) in patients with ischemic heart disease (IHD).
56 patients with IHD were randomized to either received freshly isolated BMC-Tx or a control group that did not receive cell therapy. The functional activity of BM-CPCs in peripheral blood (PB) was measured by migration assay and colony forming unit assay pre- and 3, 6 as well as 12 months after procedure. Global ejection fraction (EF) and infarct size area were determined by left ventriculography.
Intracoronary transplantation of autologous freshly isolated BMCs led to a significant reduction of infarct size and an increase of global EF as well as infarct wall movement velocity after 3 and 12 months follow-up compared to control group. The colony-forming capacity of BM-CPCs significantly increased 3, 6 and 12 months after cell therapy compared to pre BMCs-Tx and control group (CFU-E: p < 0.001, CFU-GM: p < 0.001). Likewise, we found significant increase of migratory response to stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF) after cell therapy compared to pre BMCs-Tx (SDF-1: p < 0.001, VEGF: p < 0.001) and to control (SDF-1: p < 0.001, VEGF: p < 0.001). There was no significant difference of migratory- and colony forming capacity between pre- and 3, 6, 12 months after coronary angiography in control group without cell therapy.
Intracoronary transplantation of autologous freshly isolated BMCs by use of point of care system may lead to improvement of BM-CPCs functional activity in peripheral blood, which might increase the regenerative potency in patients with IHD.
KeywordsMigration capacity Colony forming capacity Ischemic heart disease Bone marrow cell transplantation
Circulating progenitor cells (CPCs) are primitive bone marrow cells (BMCs) that have the capacity to proliferate, migrate, and differentiate into various mature cell types [1, 2, 3]. Furthermore, these cells circulate in the peripheral blood (PB), and implicate in neoangiogenesis after tissue ischemia [4, 5]. Cell therapy is a promising novel option to improve vascularization or cardiac regeneration [6]. In animal models, bone marrow-derived stem/progenitor cell infusion improves cardiac function and neovascularization after myocardial infarction [7, 8, 9, 10]. Additionally, clinical trials indicate a benefical effect of intra coronary infusion of BMCs or circulating progenitor cells (CPCs) on myocardial function in patients with acute myocardial infarction (AMI) [11, 12, 13, 14, 15]. Moreover, it has been suggested that cardiovascular risk factors (CVRFs) are associated with reduction of functional activity of BM-CPCs in patients with coronary artery disease as well as in healthy men [16, 17]. It is unknown whether freshly isolated BMCs transplantation and the functional activity of BM-CPCs in PB have beneficially affects postinfarction remodelling. In this prospective randomized control trial, we analyzed the influence of intracoronary freshly isolated cell therapy by use of point of care system on cardiac function and on the functional activity of the bone marrow derived circulating progenitor cells (BM-CPCs) in patients with ischemic heart disease (IHD).
In a prospective randomized controlled trial, patients between 18 and 80 years of age were eligible for inclusion in this study if they had had a documented MI at least 3 months and had a clear-cut demarcated region of left ventricular dysfunction with an open infarct-related coronary artery at the time of stem cell therapy. Exclusion criteria were the presence of acutely decompensated heart failure with a New York Heart Association (NYHA) class of IV, infectious or inflammatory disease, active bleeding, surgery or trauma within 2 months, renal or liver dysfunction, thrombocytopenia, or anemia, alcohol or drug dependency, a history of other severe chronic diseases or cancer, or unwillingness to participate. The local ethics committee approved the study protocol. All IHD patients were discharged with standard medication consisting of acetylsalicylic acid and/or clopidogrel, an ACE inhibitor, a ß-blocker and a statin.
Study Protocol
Preparation and Administrations of BMC
A total of approximately 120 mls of bone marrow was aspirated from the iliac crest after local anesthesia and mononuclear cells were isolated and identified including CD34+ and CD133+. The bone marrow cell concentrate suspension was isolated by use of point of care system (Harvest BMAC System, Harvest Technologies GmbH, Munich, Germany) according to the manufactures instructions for use to produce 20 mls of concentrated cells. The concentrate consisted of a heterogeneous cell population including hematopoietic, mesenchymal, other progenitor cells as well as granulocytes and platelets.
After undergoing arterial puncture, all patients received 7500–10000 Units of heparin. Cell transplantation was performed via the intracoronary administration route [12] using four fractional infusions parallel to balloon inflation over 2–4 min of 5 ml of cell suspension. All cells were infused directly into the infarcted zone through the infarct related artery via an angioplasty balloon catheter, which was inflated at a low pressure (4 atm) and was located within the previously stented coronary segments. This prevented back flow of cells and produced stop flow beyond the site of balloon inflation to facilitate high-pressure infiltration of cells into the infarcted zone with prolonged contact time for cellular migration. Three months after catheter-guided cell transplantation, all functional tests were repeated, including coronary angiography and left ventriculography. There were no procedural or cell-induced complications and there were no side effects in any patients.
Coronary Angiography and Left Ventriculography
Patients in both groups underwent left heart catheterization, left ventriculography and coronary angiography. Cardiac function and infarct size were determined by left ventriculography. Cardiac function was evaluated by global EF and by auxotonic myocardial contractility index, evaluated by the wall movement velocity of the infarcted area. Global EF was measured with Quantcor software (Siemens, Erlangen/Germany). To quantify the size of infarct area we used the centreline method according to Sheehan [18] by plotting five axes perpendicular to the long axis of the heart in the main akinetic or dyskinetic segment of ventricular wall. Systolic and diastolic lengths were then measured by two independent observers, and the mean difference was divided by systolic duration in seconds. The follow-up was 3 and 12 months after the treatment. All hemodynamic investigations were obtained by two independent observers.
Isolation and Cultivation of BM-CPCs
20 ml peripheral venous blood was taken using a BD Vacutainer CPT™ from each patient. BM-CPCs were isolated by density gradient centrifugation. After 2 washing steps, cells were resuspended in 1 ml EBM2-medium (Cell system). The number of isolated BM-CPCs were determined in a Neubauer chamber [17, 19].
Assessment of Migration Assay
A total of 1 × 106 BM-CPCs were resuspended in 250 μl X-Vivo and placed in the top compartment of a Boyden Chamber. This chamber was placed in a 24-well culture dish contained either only EBM-2 medium or 100 ng/ml stromal cell derived factor-1 (SDF-1) or 100 ng/ml vascular endothelial growth factor (VEGF) in EBM2-medium. After 24 h of incubation at 37°C transmigrated cells were counted by 2 independent investigators [17, 19]. Quantitative evaluation of migrated cells to SDF-1 and VEGF were analyzed in comparison to cells without chemokine in blood samples of both groups. Values are expressed as% of migrated cells without chemokine.
Assessment of Colony Forming Unit Assay
1 × 105 in BM-CPCs per ml were seeded in Methocult GF H4435 (Stemcell Technologies). Culture dishes were seeded with 1 ml cell suspension and then incubated at 37°C. Colony-forming unit erythroid (CFU-E) and CFU-granulocyte/macrophage (CFU-GM) were studied under phase-contrast microscopy and were counted after 14 days of incubation by 2 independent investigators [19].
Safety Parameters
To assess any inflammatory response and myocardial reaction after cell therapy, white blood cell count, the serum levels of C-reactive protein (CRP) and of creatine kinase (CK) were determined immediately before and after treatment. Additional analysis was done directly after transplantation and 3, 6, 12 months later: BNP level in PB, ECG at rest, 24-h Holter ECG and echocardiography. Procedural complications were defined as any ventricular arrhythmia, visible thrombus formation, distal embolization, or injury of the coronary artery associated with the cell infusion catheterization procedure.
Statistical Analysis
Quantitative data are presented with mean ± SD and qualitative data are tabulated using absolute frequencies and/or percentages. Differences between therapy groups for qualitative variables were tested using Fisher's-Exact-Test due to small number of patients in therapy groups. Within differences of quantitative variables in each therapy group are compared using the Wilcoxon-Test for depending samples, and differences between therapy groups of quantitative variables are compared with the Wilcoxon-Test for independent samples. Both of those nonparametric Wilcoxon-Tests are preferred due to the more likely expected non-normal distribution of the data. For all statistical tests, a result will be seen as statistically significant, if the corresponding two-sided p-value is smaller or equal to 0.05. If the mean and the median did not differ markedly for a variable, the graphical presentation of the data was be done using the mean and SD of this variable. Statistical analysis was performed with SPSS for Windows (Version 15.0)
Baseline Characteristics of The Patients
Baseline clinical characteristics of patients with ischemic heart disease with bone marrow cells transplantation and control group without transplantation
IHD with BMCs-Tx (n = 38)
IHD without BMCs-Tx (n = 18)
62 ± 10
60 ± 9
Cardiovascular Risk Factors (%)
Positive family history of CAD
Transmural myocardial infarction, months before Tx
28 ± 13
27 ± 14
No. of diseased vessels
1.9 ± 0.5
2.0 ± 0.6
Infarct-related vessel (LAD/LCX/RCA)
PTCA/Stent at the time of AMI
Medication (%)
ACE inhibitor or AT II blocker
Aldosterone Antagonist
Laboratory parameters
2018 ± 560
2000 ± 740
Effect of BMCs Transplantation
Left Ventricular Function, Infarct Size and Infarct Wall Movement Velocity
Cardiac function, clinical function status parameters and functional activity of BM-CPCs at baseline and 3, 6 as well as 12 months after freshly isolated BMCs-Tx in the firstgroup
Immediately pre BMCs-Tx
3 months after BMCs-Tx
6 months after BMCs-Tx
12 months after BMCs-Tx
Global EF (%)
46 ± 10
53 ± 8 *
52 ± 8 *
The size of infarct area (%)
27 ± 9
19 ± 8 **
18 ±5 **
Infarct wall movement velocity (cm/s)
1.80 ± 0.74
2.98 ± 0.89 **
3.45 ± 0.5 **
LVEDV (ml)
138 ± 34
139 ± 32 ***
138 ± 32 ***
LVESV (ml)
75 ± 20
65 ± 10 *
66 ± 10 *
SVI (ml/m2)
34 ± 10
42 ± 9 *
41 ± 8 *
Migration capacity
Cytokine SDF-1 (%)
85 ± 10
127 ± 13 **
130 ± 20 **
129 ± 19 **
Cytokine VEGF (%)
92 ± 9
134 ± 15 **
141 ± 22 **
142 ± 28 **
Colony forming unit capacity (CFU)
Erythroid (CFU-E)
48 ± 5
99 ± 15**
116 ± 22**
112 ± 20**
Granulocyte Makrophage (CFU-GM)
13 ± 3
32 ± 5 **
38 ± 8 **
40 ± 7 **
BNP (pg/ml)
159 ± 73
65 ± 25 **
65 ± 27 **
66 ± 19 **
NYHA classification
2.4 ± 0.4
1.69 ± 0.6 **
1.6 ± 0.5 **
1.6 ± 0.6 **
Cardiac function, clinical function status parameters and functional activity of BM-CPCs at baseline and 3, 6 as well as 12 months after coronary angiography in control group without BMCs-Tx
Immediately pre coronary angiography
3 months after coronary angiography
6 months after coronary angiography
12 months after coronary angiography
Global EF (%)
46 ± 10
47 ± 7***
46 ± 9***
The size of infarct area (%)
29 ± 9
28 ± 9***
26 ± 8***
Infarct wall movement velocity (cm/s)
1.86 ± 0.96
1.93 ± 0.76***
1.99 ± 0.9***
LVEDV (ml)
141 ± 28
142 ± 31***
140 ± 30***
LVESV (ml)
76 ± 17
75 ± 15***
76 ± 16***
SVI (ml/m2)
36 ± 10
35 ± 8***
34 ± 9***
Migration capacity
Cytokine SDF-1 (%)
88 ± 10
91 ± 10***
90 ± 10***
85 ± 16***
Cytokine VEGF (%)
98 ± 5
102 ± 9***
100 ± 20***
98 ± 15***
Colony forming unit capacity (CFU)
Erythroid (CFU-E)
51 ± 5
49 ± 10***
49 ± 13***
50 ± 15***
Granulocyte Makrophage (CFU-GM)
12 ± 2
12 ± 4***
15 ± 8***
11 ± 6***
BNP (pg/ml)
157 ± 84
130 ± 80***
128 ± 60***
141 ± 42***
NYHA classification
2.5 ± 0.9
2.45 ± 0.9***
2.1 ± 0.7***
2.3 ± 0.6***
Functional Status and Clinical Safety Parameters
ECG at rest, on exercise and 24-h Holter ECG revealed no rhythm disturbances. There was no inflammatory response or myocardial infarction (white blood cell count, CRP, CK) after cell therapy. No immediate periprocedure as well as post procedure adverse complications and no new electrocardiographic changes or significant elevations in CK or troponin as well as no inflammatory response were observed in patients with BMC-Tx
Functional Activity of BM-CPCs After Cell Therapy
The functional capacities of BM-CPCs were measured by migratory- and colony forming activity in both groups immediately pre- and 3, 6, 12 months after index procedure. The migratory response to SDF-1 and VEGF increased significantly 3, 6 and 12 months after intra coronary BMCs-Tx compared to baseline and to control group. In contrast, there was no significant change between baseline and 3, 6, 12 months after coronary angiography in control group (Fig. 2a and b, Tables 2 and 3). Likewise, there was a significant increase of colony forming capacity 3, 6, 12 months after cell therapy as compared to baseline and to control group. Interestingly, no significant difference was observed in the colony forming capacity between baseline and 3, 6, 12 months after coronary angiography in patients without cell therapy (Fig. 3a and b, Table 2 and 3).
In this prospective randomized controlled study we could demonstrate improved functional activity of the bone marrow derived circulating progenitor cells after intra coronary autologous freshly isolated bone marrow cells transplantation in patients with IHD.
The cellular composition of bone marrow aspirate and bone marrow concentrate by use of point of care system in the group with BMCs-Tx
Bone Marrow Aspirate (Pre Separation, 120 cc)
Bone Marrow Concentrate (Post Separation, 20 cc)
Total nucleated cells (×106 ml)
25 ± 9
99 ± 25
CD34+ cells (×106 ml)
0.21 ± 0.07
0.95 ± 0.1
CD133+ cells (×106 ml)
0.07 ± 0.004
0.35 ± 0.02
Platelet count (×103 /μl)
155 ± 19
705 ± 174
Viability of cells (%)
98 ± 1.5
Several hypotheses have been proposed about, how intracoronary cell therapy improves myocardial function. I) Experimental studies addressing the capacity of transplanted bone marrow-derived stem cells to differentiate into the cardiomyogenic lineage yielded conflicting results. Recent well-conducted studies suggest that the BMCs do not transdifferentiate into cardiomyocytes but adopt mature hematopoietic characteristics. In contrast to embryonic stem cells, most adult stem or progenitor cells do not spontaneously differentiate into cardiomyocytes but rather require an adequate stimulus to do so. II) Another proposed mechanism is that cell therapy may increase angiogenesis and improve blood supply to ischemic regions, potentially aiding in the revascularization of hibernating myocardium and inhibiting cardiomyocyte apoptosis. Additionally or alternatively, the local microenvironment plays an important role to induce cell fate changes by physical cell-to-cell interaction or by providing paracrine factors promoting tissue repair [31, 32].
Cell-based therapy is a promising option for treatment of ischemic disease. However, cell therapy is in its early stages, and various questions remain. BMCs are best characterized and have been used in the majority of clinical trials performed to date. BMCs contains a complex assortment of progenitor cells, including hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs) or stromal cells and multipotential adult progenitor cells (MAPCs) [33]. BM-CPCs is another population of progenitor cells that has also been shown to have therapeutic potential in the pool of progenitor cells circulating within the blood. BM-CPCs are capable of proliferating and differentiating into endothelial cells and are therefore candidates for vascular regeneration [34, 35, 36]. Experimental and clinical studies suggest that the systemic application or mobilization of stem cells and progenitor cells beneficially influences the repair of endothelial cells after injury and the progression of atherosclerosis [37, 38, 39, 40, 41]. Previous studies demonstrate that risk factors for coronary artery disease correlate with number and functional activity of BM-CPCs [17]. Not only is the quantity of BM-CPCs altered, but their function is also modified by ischemic conditions and therapeutic interventions [19]. Migration is essential for the stem/progenitor cells to invade the ischemic tissue. SDF-1 and VEGF are both profoundly upregulated in hypoxic tissue [42, 43] and thus represent physiologically relevant chemoattractants for the recruitment of circulating progenitor cells to sites of ischemia. Indeed, intramuscular injection of the chemoattractant chemokine SDF-1 has recently been shown to increase the number of incorporated BM-CPCs and to improve neovascularization in vivo [44]. Thus, the migratory response toward SDF-1 may indeed play a crucial role for integration of BM-CPCs in ischemic tissue. In addition, the accumulation of cardiovascular risk factors or an increased overall risk is associated with impaired colony forming activity of CPCs in healthy men [16]. We found significant increase of migratory activity and colony forming activity after cell therapy in contrast to control group without cell therapy. The occurrence of a first major cardiovascular event (acute myocardial infarction, hospitalization, revascularization or death from cardiovascular causes) was associated with reduced BM-CPCs levels and functional activity in patients with coronary artery disease [45]. Moreover, intra coronary administration of BMCs is associated with a significant reduction of major adverse cardiovascular events after AMI [46]. Previous studies demonstrate that patients with heart failure (HF) show endothelial dysfunction and in HF, nitric oxide production is diminished, whereas rate of endothelial apoptosis is increased [47, 48]. Moreover, the impaired neovascularisation in mice lacking eNOS is related to defect in progenitor cell mobilization from bone marrow [49]. Mechanistically, the improved perfusion capacity, which was demonstrated in the pilot TOPECARE- and REPAIR-AMI trial in patients after cell therapy, may increase epicardial artery shear stress and stimulate the endothelium to release NO, which may enhance the functional activity of BM-CPCs and exerts antiatherosclerotic functions [50, 51]. Additionally, The presence of immature circulating cells in the peripheral blood has been advocated as a marker of an organism's regenerative capacity [52].
The primary limitation of this study is the lack of placebo arm and the measurement of cardiac imaging. Moreover, for better understanding we added left ventricular volume data in our study, which was also investigated in several trials [11, 12, 15, 26, 27]. Therefore, a placebo-controlled study will be needed to validate the hypothesis.
In the present study we could demonstrate that intracoronary transplantation of autologous freshly isolated BMCs improved global EF and reduced infarct size significantly in patients with IHD after 3 and 12 months. Moreover, we observed a significant improvement of BM-CPCs functional activity even 3, 6 and 12 months after cell transplantation. This interesting observation could be implemented in future large-scale randomized studies, where the BM-CPCs functional activity after transplantation may serve as predictor for identifying IHD patients with greater benefit after cell therapy.
The authors indicate no potential conflicts of interest.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.


text:
Derby, Sep 23: India batsman Cheteshwar Pujara today was given out "handled the ball" while playing for Derbyshire against Leicestershire in the County Championship Division Two match. He is the first Indian batsman to be dismissed in this way in first-class cricket.
On Tuesday, the opening day of the four-day match, Pujara was given out "handled the ball" for 6 (21 balls, 28 minutes, 1x4) at the County Ground in Derby, "BBC" reported.
"India Test batsman Cheteshwar Pujara has been given out "handled the ball" on the opening morning of Derbyshire's County Championship Division Two game against Leicestershire at Derby," the report said.
"His dismissal in the 20th over left Derbyshire on 62/3, having been put in by their East Midlands neighbours.
The last instance of a player being given out handled the ball in England was Karl Krikken, playing for Derbyshire against India on the same ground in 1996," the report added.
This was the 59th instance of "handled the ball" dismissal in first-class cricket. In international cricket, there have been 9 "handled the ball" dismissals. India's Mohinder Amarnath was given out for handling the ball in a ODI against Australia in 1986 at Melbourne Cricket Ground (MCG).
What the Law says
1. Out Handled the ball
The striker is out Handled the ball if, except in the circumstances of 2 below, in the act of playing a ball delivered by the bowler, he wilfully strikes the ball with a hand not holding the bat. This will apply whether No ball has been called or not and whether it is the first strike or a second or subsequent strike.
The act of playing the ball shall also encompass both playing at the ball and striking the ball more than once in defence of his wicket.
2. Not out Handled the ball
Notwithstanding 1 above,
(a) the striker will not be out Handled the ball if the strike with a hand not holding the bat is in order to avoid injury.
(b) the striker will not be out Handled the ball but will be liable to be out Obstructing the field if he makes a strike with a hand not holding the bat
(i) unless trying to avoid injury, as a lawful second or subsequent strike which prevents a catch. See Law 37.3 (Obstructing a ball from being caught).
(ii) unless trying to avoid injury, after he has completed the act of playing the ball, as defined in 1 above.
(iii) at any time while the ball is in play, to return the ball to any fielder, without the consent of a fielder. See Law 37.4 (Returning the ball to a fielder).
3. Bowler does not get credit
The bowler does not get credit for the wicket.


text:
Albany: Microsoft Project 2010 - Trivia session 1
Wednesday, March 5, 2014 from 6:00 PM to 7:30 PM (EST)
Event Details
Event Description:
In this session, we will review questions from the MPUG 70-178 Exam Study Guide, trivia style, to continue preparing for the exam.
Learning Objectives:
During this event, students will learn elements of MS Project 2010 that may be in the certification exam.
Speaker Bio:
James Kelleher is a member of MPUG-Albany chapter since it was founded.
When & Where
New Horizons of Albany
10 Airline Dr, Suite 101
Wednesday, March 5, 2014 from 6:00 PM to 7:30 PM (EST)
Add to my calendar
Where Project Managers and Microsoft® Meet. MPUG delivers our users relevant and independent Microsoft Project Management content, resources, opportunities and community networking world wide. MPUG connects thousands of project management practitioners -- to help them better leverage their investment in Microsoft tools such as Microsoft Project, Excel and Sharepoint for Project Management and ultimately advance their businesses and careers.


text: Our focus is to continue to enhance this service model with the objective of providing our customers the best and safest service in the industry.Now our legacy inland tank barge business is performing well with favorable pricing trends. We anticipate this sector to remain positive based on the favorable outlook of the U.S. petrochemical and refining industry. For the Diesel Engine segment, our legacy business is improving due to the overall health of it inland marine transportation customers and an improved Gulf of Mexico oil service market. For our land-based Diesel Engine Service business, with the current low price of natural gas incentive to drill for natural gas has declined but the incentive to find crude oil remains very positive due to the current high price of crude oil. This business is seeing a natural rotation away from natural gas to oil exploration. As this rotation occurs, there has been a pause in new orders for the oil service equipment as the market assesses its requirements. We are using this pause to further develop the service opportunities in this business. When we purchased United it was our objective to apply a very good, well-tested marine diesel engine service model to land-based diesel engines. It is our intention to continue to build oil service equipment, but to more heavily focus on servicing this equipment rather than manufacturing it. Later in the call Greg will share with you some encouraging comments regarding remanufacturing service opportunities. Then I'll come back at the end of the call and talk about the second quarter as well as the full year outlook. Now I'm going to turn the call over to David, who will speak briefly about Kirby Offshore Marine's markets and then Greg will update you on our inland tank barge business and the Diesel Engine Service markets. Read the rest of this transcript for free on seekingalpha.com


text:
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text:
Hello, I ran my case with b
I ran my case with both OpenFoam (sonicTurbFoam) and CFX5 and compared
results by generating graphs of temperature, pressure, mass and mass flow rate
as well as some contour screenshots (see attached images). In principle,
the axisymmetric-2D-system is a simple volume with an inlet. For OpenFoam
a 5° sector was used with wedges.
I found that temperature and pressure of OpenFoam are lower than the corresponding
results of CFX-5. Additionally, in OpenFoam the overall mass in the closed volume
is lower than the integral value of the inlet mass flow rate. Thus, it looks as if
mass is lost during the calculation. Note, the massflow input (and also the
total temperature) at inlet is nearly the same as in CFX5. The mesh was the same,
of course.
I have checked a lot of things: turbulence model, boundary conditions, thermal
properties, etc, but haven't found the reason why in OpenForm the mass balance (and
consequently the energy balance) is not fulfilled. The schemes I used are:
================================================== ============================
default CrankNicholson 0.5;
default Gauss linear;
default none;
div(phi,U) Gauss limitedLinearV 1;
div(phi,k) Gauss upwind;
div(phi,epsilon) Gauss upwind;
div(phi,R) Gauss upwind;
div(R) Gauss linear;
div(phid,p) Gauss limitedLinear 1;
div(phiU,p) Gauss limitedLinear 1;
div(phi,h) Gauss limitedLinear 1;
div((muEff*dev2(grad(U).T()))) Gauss linear;
default none;
laplacian(muEff,U) Gauss linear corrected;
laplacian(DkEff,k) Gauss linear corrected;
laplacian(DREff,R) Gauss linear corrected;
laplacian(DepsilonEff,epsilon) Gauss linear corrected;
laplacian((rho*1|A(U)),p) Gauss linear corrected;
laplacian(alphaEff,h) Gauss linear corrected;
default linear;
default corrected;
default no;
================================================== ============================
I've also used Euler time discretisation, but nothing changed. So far, I didn't
change the spatial discretisation, it's still the default setting from prism.
The solution settings are:
================================================== ============================
p BICCG 1e-12 0;
rho ICCG 1e-12 0;
U BICCG 1e-12 0;
h BICCG 1e-12 0;
k BICCG 1e-12 0;
epsilon BICCG 1e-12 0;
R BICCG 1e-12 0;
momentumPredictor yes;
nCorrectors 2;
nNonOrthogonalCorrectors 0;
pRefCell 0;
pRefValue 0;
================================================== ============================
Thus, does anybody have an idea where the problem could be? The unconserevd
energy and mass balance make me uncomfortable ;-(
Don't you need CrankNicholson
Don't you need CrankNicholson 1.0 for fully second order accuracy?
Regards, Frank
I also used Euler here, it doe
I also used Euler here, it doesn't matter so much I think. Other ideas?
How did you calculate the syst
How did you calculate the system mass, m, the dotted curve in the t vs. (m0 - m) plot ?
The system mass is calculated
The system mass is calculated by using pV=mRT, p and T are the mean values within the volume. Then I get the mass(m) value for each saved step, subtract the initial mass m0.
If I understood correctly you
If I understood correctly you are calculating the mass as m = V/R {p}/{T}. Where { } denotes the volume average. Have you tried calculating the mass as m = V/R {p/T} ?
Yes, your idea turned out to b
Yes, your idea turned out to be correct! I have checked the (m-m0) again by using your proposal m = V/R {p/T}, the mass is now conserved. Thanks a lot! But any idea about the pressure and Temperature?
If you really want to integrat
If you really want to integrate the influx, you should look at *exactly* what goes in. That is exactly what's on the boundary patch. Not what's in the cell next to it... In addition, your own way of integarting plays a role. Is *your* integration 100% identical with the OpenFOAM time integration? For example using mid-point values matching the CN scheme?
It's relatively easy to assure mass conservation in a fv code like OpenFOAM, and from the quality in detail I've seen so far in OpenFOAM it would be profoundly surprising if you found a lack of mass conservation. "Surprising" is too weak a word, actually.
You are right! My incorrect po
You are right! My incorrect postprocessing calculation introduced the error. Now mass is conserved. But there are still problems during the simulation that make temperature and pressure smaller than that of CFX-5. any further suggestion?
Then remains to compare exactl
Then remains to compare exactly how much influx of enthalpy you have in the two codes. If I understood correclty, there's no heat production inside? If the mass inventory is the same in both codes at time t, then you only need to look for the enthalpy influx. Same here: I doubt they've missed conservation in CFX5 or OpenFOAM... It's likley a matter of how sources or inlet properties are defined. Even if you think you do they same in both codes, the codes may have different conventions for how things are defined on the boundary.
The finding is that the enthal
The finding is that the enthalpy flow of OpenFOAM is very close to that of CFX5.
Here, we have checked the static part, mdot*h_static, as well as the kinetic part mdot*u²/2. Both are the same on the inlet for OpenFoam and CFX.
I inspected this by considering each cell at inlet then summing up them. Using the same method, I also checked the pressures and velocities at inlet from both tools. They are nearly the same. The inlet calculation seems to be no problem. But I still cannot figure out what kind of problem causes the different pressure and temperature values within the volume. Can you give me more suggestions?
Did you run CFX with viscous d
Did you run CFX with viscous dissipation. The energy equation in sonicTurbFoam, "hEqn.H", does not appear to have a viscous dissipation term, which might explain a few degrees of temperature difference.
In the setting of heat transfe
In the setting of heat transfer model "Total Energy" in CFX5, option "Incl. viscous Work Term" was _not_ activated.
Have you done the same check o
Have you done the same check on energy/enthalpy conservation as you did for the mass? (total energy in the flow domain before/after in relation to the enthalpy influx.) If energy is conserved, then I guess there's only the consitutive relationship, etc., relating pressure to temperature and enthalpy...
Now the situation is that if I
Now the situation is that if I subtract the mean temperature <t> of OpenFoam with 293 and multiply with gamma (gamma=cp/cv), then I get almost the same temperature as in CFX5. So I guess the wrong equation is being used in calculating temperature in OpenFOAM. Any suggestion?
It's a bit hard to say OpenFOA
It's a bit hard to say OpenFOAM solves the "wrong" equation, isn't it? Sounds to me OF uses SI units for temperature (Kelvin), while CFX5 uses something else. The factor gamma can be explained if someone used cv instead of cp, or vice versa. Sounds to me it's more a question of reading in the manuals/case files to know what is actually calculated and ensuring you use the same physical properties and units in both codes. That's obviously the user's responsability. Should be easy enough in OF, just have a look in the source code.
One other thing you might take
One other thing you might take look at is the turbulence model. For example in:
the R() function includes a "(2/3)*k" term, however divRhoR() does not include this term.
The quickest fix is to add
-(2/3)*fvc::grad(rho*turbulence->k() )
after the fvc::grad(p) term when the momentum equation is solved.
Thank you so much. I have chan
Thank you so much. I have changed the code by using your suggestion. But unfortunately, the result is nearly the same as before.
I'm still thinking the "gamma" plays the key role here. So please give me more hints based on my previous post. Thanks again!
Can someone comment if David i
Can someone comment if David is right because this would be a potential bug!
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Release Notes: A DatePicker component, a new engine service for linking into Tapestry from external applications, and client-side form validations were added. Dynamically generated HTML is now in XHTML format. Documentation is now available in both HTML and PDF format.
Release Notes: Tapestry now uses the Object Graph Navigation Library, which allows more logic to be expressed in the component specification rather than in Java code. There is now a complete Component Reference as part of the documentation.
Release Notes: This release adds extensions, configurable objects attached to the library, and application specifications. It now also handles forwards (to HTML or JSP files) properly.
Release Notes: A new mechanism for packaging components (along with related pages and engine services) as libraries, and a namespace mechanism to disambiguate names.
Release Notes: A number of bugs in ValidatingTextField were fixed. The service parameters were reworked to be typed objects, rather than simple strings. The URL format was simplified and improved. Specifications are now more heavily validated. The page and component specifications were split into two separate entities.
Release Notes: This release bundles Jetty 4.0.4. Scripts can now use an Ant-like syntax. Many minor annoyances from 2.1 are now fixed.
Release Notes: Significant changes were made since Tapestry release 2.0. Localization has been greatly enhanced. Each component may now have its own set of localized strings, with easy access to those strings in the component specification and in the component HTML template. Tapestry can now connect a component's parameters to the JavaBeans properties of the component class. This simplifies component development and matches developer expectations. Tapestry now automatically configures and deploys itself into JBoss 3.0.0. Java packages were renamed from com.primix.tapestry.* to net.sf.tapestry.*.
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Release Notes: Fixes for several minor bugs, and updated build scripts to auto-configure the Tapestry demonstrations into JBoss 3.0.0 (previous releases worked with 2.4.3).


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Juncos Vacation Packages
Juncos is within easy reach of a diverse collection of Puerto Rico Island's attractions. Among the most interesting places to see are the fascinating El Yunque National Forest and the incredible Luis Munoz Marin Foundation. And if your schedule allows, be sure to visit the Palmas del Mar Beach and Jardin Botanico.
To better understand Puerto Rico Island, visit one of its fabulous cultural destinations. Step inside the many museums here such as the Museo de Arte de Puerto Rico in San Juan. Experience a couple of the popular live shows at the Centro de Bellas Artes Luis A. Ferre in San Juan. Acclaimed art galleries, include the Museo de Arte Contemporaneo de Puerto Rico in San Juan and the Museum of History, Anthropology and Art.
If the weather is good, follow the lead of the locals who know the area best and head outside to the nearby green spaces. Inhale the salty air, play catch with the kids and catch some rays at nearby Luquillo Beach in Luquillo, Azul Beach and Playa Larga in Yabucoa. The nature reserves such as the Pinones State Forest in Loiza, allow visitors to see the species of flora and fauna that exist in the local area. There are some pleasant family parks, so why not take a break in Ocean Park in San Juan, the Luis Munoz Marin Park and the Parque Central Municipio de San Juan.
Take a break from the tourist trail and play a game of golf at the Rio Bayamon Golf Course in Bayamon.
Browse the boutiques and purchase some original souvenirs in some of the nearby malls and markets such as the Plaza las Americas in San Juan and the Plaza del Mercado.
Sports fans vacationing in Juncos should get tickets for Sixto Escobar Stadium, San Juan to see the River Plate Puerto Rico doing battle with visiting teams. On match days follow the procession of red and white, to the stadium, then after the full-time hooter blows, join fans at a nearby pub, bar or cafe for a post-game drink.
When it's time to rest your weary head after discovering the delights of Juncos, check in to one of the area's many bed-and-breakfast, hotel and short-stay apartment options. The San Juan Marriott Resort and Stellaris Casino, the Wyndham Grand Rio Mar Beach Resort & Spa, Rio Grande and the El San Juan Resort & Casino, A Hilton Hotel, Carolina are just three of the best places to stay while you are enjoying this special area.


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THREADS Thursday #28 – Anti Social Social Club FW16 D2
Streetwear brand Anti Social Social Club has dropped off a second delivery from their Fall Winter 16 collection. The brand's been popular for a minute, known for their minimal branding, simplistic designs, and major exclusivity. This drop maintains the aesthetic they've built, containing tees, sweaters,


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You are taking on the major role of King Lear. What have been some of your favorite past roles to play and why?
I think my favorite role thus far was playing Big Daddy in Tennessee William's Cat on a Hot Tin Roof. That had never been on my bucket list, but it was one of the most enjoyable roles I've played because I seemed to trip into the core of that character early on and it was fairly easy sailing after that. That's what you look for as an actor - a role which you can connect with. It's hard to explain, just something you know when you get there. And, oftentimes, it's not the role you thought you always wanted to play. For most roles, you have to work at achieving that bond, and sometimes, never quite make it. You can still be good, but it's just not as much fun. As an actor, I look for something that can trigger that connection. I never know exactly where that will come from. Sometimes, it never does. For Big Daddy, it was the accent. Once I had that down (I worked with local poet and Mississippi-born Jim Autry a lot on it), I could get into the rhythm of William's dialogue, which led me to the core of the character. That's one thing many actors miss. Listen to the words that the playwright gives you - and I mean really listen to them! - and that will lead you where you need to go instead of imposing on the character what you think he or she should be. Another favorite role for me was the first production of RTI as a company - Joe Kellar in Arthur Miller's All My Sons. The "character trigger" for that role was the way he got out of a chair, kind of slowly like he had back problems from years of manual labor. It was just a little thing, nothing major. I got that from watching a 1980's film of the play, starring James Whitmore in the role. Now, there is nothing even remotely similar to me and James Whitmore, but that was the one thing I picked out of watching his performance that was a trigger for me. And I had James Serpento as a director to guide me. Other roles I've enjoyed playing are Scrooge and Shylock in The Merchant of Venice. I probably never will, but I'd like to have another shot at Shylock. When we did it two summers ago, there was too much going on with my duties as Managing Director of RTI to fully focus on the role. But, I think I did all right. No "trigger" though, just an interpretation of a man who was not going to a victim of the anti-semitism in that world.
King Lear is one of the most iconic roles in all of theatre - what is it like/what does it mean to you to take on this role?
Yes, it is an iconic role, but an actor can't think about that or he/she will be too intimidated to do the job. I've always said you do the classics at your own peril, because anyone who knows the play will have his/her own ideas of how the play or the role should be done. I've always dreamed of playing Lear, but for obvious reasons, I needed to reach a certain age and life experience to even attempt it. When Brad Dell (the director) asked me to do it, my first thought was "Am I worthy?", since it is one of the most revered roles in the Shakespeare canon. When I finally answered my own question with "Probably not, but how many actors are?", I felt more confident about taking on this challenge. The play will live on forever. I can put my print on it for local audiences. That's all one can expect.
In what ways do you see this role and play as relatable to modern audiences and our contemporary world?
This question always bugs me a bit because the assumption seems to be that if a play is not "relatable" to our modern world, then it's not worth doing. What if it's not specifically relatable to our times? What if it's just relatable to a time gone by? If it's a compelling enough story and written well-enough, it's still worth doing. We don't put that same criteria on classical music, for instance. Who asks if Mozart is relatable? His music is beautiful and moving, so of course, it's relevant. The same criteria should hold for drama, or any art form. If it's done well, it is worth doing on its own terms.
But, to try to answer the question about how relatable King Lear is to our contemporary worlds, it is about growing old, ageism, the expectations of an older generation towards the one following, and, of course, dementia, which I think Lear definitely suffers from. It's also about the breakdown of order, which is a theme with both plots of the play. That is an issue which definitely should reverberate with modern audiences because there is this anxiety and insecurity in the U.S., and throughout the world, today. I think that has really come to the forefront in this election cycle. And like with any play that rises to "classic" or "iconic" stature, it's just a well-constructed, entertaining story that has attracted audiences for 400 years.
What most excites you about playing this role? What is the biggest challenge of playing King Lear?
Well, my wife keeps warning me not to embarrass her, so that's definitely a challenge! Lear is a quixotic character. He can go from one emotion to the next in a nano-second. That trait is obvious from the first scene. The challenge is to make sure those emotions are motivated, or we just have shouting matches and then tears. Lear has a quick fuse and that's not a stretch for me. But, his anger comes out of immense frustration, fear, impotency, which reduces him him tears. How to play that, especially the final scenes with Cordelia, will be a big challenge. But, I have a lot of help from Shakespeare if I just listen.
Another challenge is the lines. He has a lot of them, but that doesn't worry me. As with any Shakespeare, you also have to be aware of the verse and how to use it so that it sounds like language and not a sing-song delivery or oratorical recitation. And then, there's the syntax. Shakespeare messes with word order for the sake of poetry. At times, the lines sound almost like Yoda in Star Wars. Here's an example. In Act I; Sc 4, Lear finds Kent in shackles. He asks him, "What's he that hath so much thy place mistook...?" In modern English, it would be more natural to say, "What's he that hath mistook thy place so much....?" But, it doesn't sound as good that way. You can find examples of that all through the play. It's just another challenge that you don't have in more modern drama.
And, finally, remembering who your character is in the play in order for the larger story to be told. That's a bit easier to keep track of in this play. Since Lear is the title character, so much of the story is about him.
Why do enjoy performing and in particular performing with Repertory Theater of Iowa?
I've gone in-and-out about enjoying being an actor my whole life, but it keeps drawing me back. When I've stopped enjoying it, I've stopped doing it. That happened for about 12 years when I moved from New York to take a teaching job (not in theatre) at the University of Arkansas in the '90's and early 2000's. It was not until I returned to Iowa that I got back into theatre. So, after all these years, I still don't really know why theatre excites me. Maybe it's just because acting is something I do reasonably well. I know I love going to theatre. It can be the most gratifying experience when the play is well done, and most excruciating when it isn't.
Working with RTI is an easier question to answer. When I came back to Des Moines and considered rejoining the theatre community, I told myself if I was going to do it in this venue without monetary or career rewards, then I wanted to do the plays I wanted to do and with the people I wanted to do them with. That's why I teamed up with Joseph Leonardi in 2007 when RTI was a theatre, but not a company. I suggested the theatre needed to do something different, and that having a resident company of local theatre artists with the ambition of becoming a resident professional theatre here in central Iowa would certainly be unique. And then, if we did something no one else was doing, namely focusing on the classics, then that might give us our niche in the local theatre community. Working with this group of players has been a joy. If the play is the thing, then it really doesn't matter where you do it as long as it's a body of work you can be proud of. And I think that we as a company have achieved that. We've had some outstanding productions, a lot of very good ones, and maybe a couple that weren't so good, but our record and contribution to theatre in Des Moines cannot be refuted. It's not unlike a sports team. If you work with the same players a lot, you get to know each other in ways that you don't when you are acting with a new cast for every production. That can be fun, too, but the closeness you build over the years with a band of players has much better chance of achieving a holistic theatrical experience for everyone. For this actor, that is a career worth having.
Is there anything else you would like to add about this upcoming experience?
King Lear isn't done that much around here, so this may be the only chance audiences have of seeing it anytime soon. We're early in the rehearsal process, but I feel we have the makings of a very memorable production. I hope audiences come. Pray for good weather for the week of June 13 - 19!


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Chapter Fifteen
Jesus announces that the law of Moses is fulfilled in him—The Nephites are the other sheep of whom he spake in Jerusalem—Because of iniquity the Lord's people in Jerusalem do not know of the scattered sheep of Israel. [A.D. 34]
1 AND now it came to pass that when Jesus had ended these sayings he cast his eyes round about on the multitude, and said unto them: Behold, ye have heard the things which I taught before I ascended to my Father; therefore, whoso remembereth these sayings of mine and doeth them, him will I raise up at the last day.
2 And it came to pass that when Jesus had said these words he perceived that there were some among them who marveled, and wondered what he would concerning the law of Moses; for they understood not the saying that old things had passed away, and that all things had become new.
3 And he said unto them: Marvel not that I said unto you that old things had passed away, and that all things had become new.
4 Behold, I say unto you that the law is fulfilled that was given unto Moses.
5 Behold, I am he that gave the law, and I am he who covenanted with my people Israel; therefore, the law in me is fulfilled, for I have come to fulfil the law; therefore it hath an end.
6 Behold, I do not destroy the prophets, for as many as have not been fulfilled in me, verily I say unto you, shall all be fulfilled.
7 And because I said unto you that old things have passed away, I do not destroy that which hath been spoken concerning things which are to come.
8 For behold, the covenant which I have made with my people is not all fulfilled; but the law which was given unto Moses hath an end in me.
9 Behold, I am the law, and the light. Look unto me, and endure to the end, and ye shall live; for unto him that endureth to the end will I give eternal life.
10 Behold, I have given unto you the commandments; therefore keep my commandments. And this is the law and the prophets, for they truly testified of me.
11 And now it came to pass that when Jesus had spoken these words, he said unto those twelve whom he had chosen:
12 Ye are my disciples; and ye are a light unto this people, who are a remnant of the house of Joseph.
13 And behold, this is the land of your inheritance; and the Father hath given it unto you.
14 And not at any time hath the Father given me commandment that I should tell it unto your brethren at Jerusalem.
15 Neither at any time hath the Father given me commandment that I should tell unto them concerning the other tribes of the house of Israel, whom the Father hath led away out of the land.
16 This much did the Father command me, that I should tell unto them:
17 That other sheep I have which are not of this fold; them also I must bring, and they shall hear my voice; and there shall be one fold, and one shepherd.
18 And now, because of stiffneckedness and unbelief they understood not my word; therefore I was commanded to say no more of the Father concerning this thing unto them.
19 But, verily, I say unto you that the Father hath commanded me, and I tell it unto you, that ye were separated from among them because of their iniquity; therefore it is because of their iniquity that they know not of you.
20 And verily, I say unto you again that the other tribes hath the Father separated from them; and it is because of their iniquity that they know not of them.
21 And verily I say unto you, that ye are they of whom I said: Other sheep I have which are not of this fold; them also I must bring, and they shall hear my voice; and there shall be one fold, and one shepherd.
22 And they understood me not, for they supposed it had been the Gentiles; for they understood not that the Gentiles should be converted through their preaching.
23 And they understood me not that I said they shall hear my voice; and they understood me not that the Gentiles should not at any time hear my voice—that I should not manifest myself unto them save it were by the Holy Ghost.
24 But behold, ye have both heard my voice, and seen me; and ye are my sheep, and ye are numbered among those whom the Father hath given me.
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|TOC Intro 1 Nephi 2 Nephi Jacob Enos Jarom Omni Words of Mormon Mosiah Alma Helaman 3 Nephi 4 Nephi Mormon Ether Moroni


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|Danese Cooper <dan...@gmail.com>
|Re: Possible community ApacheCon Europe event
|Tue, 20 Sep 2011 17:59:44 GMT
On Tue, Sep 20, 2011 at 7:22 AM, Nick Burch <email@example.com> wrote: > Hi All > > As mentioned, SAP have kindly agreed to sponsor the use of their internal > conference facilities to allow us to host an ApacheCon there. This should > allow us to run a more community style of event. Because we wouldn't be > based at an expensive hotel, and because SAP would be covering the facility > costs, we should be able to run something with a lower headline conference > fee, and a lower attendence cost. > Are you saying they are offering their accomodations? Last time I went to Walldorf, we all had to stay in Heidelburg which was really cool (ancient University town that it is)...but it meant finding transport out to SAP every day... > > There are some smaller things and some bigger things we need to consider. > > First up, when would we want to hold the event? Largely influencing this: > What's the soonest we could be ready? (We will be constrained by when the > SAP conference venue we prefer is available) > There's a nice symmetry in "every 6 months somewhere in the world"...so I'd vote for May 2012...although if our answer for providing options at the cheap end of accomodations is "universities will be between sessions and there will be cheap dorm rooms available" then we'll need to coordinate with that calendar. > > Related to this, which of the two SAP sites would we prefer? Hopefully Paul > Gotez can let everyone know the details of the two possible sites. (Paul is > an Apache committer who works at SAP and who's been doing amazing work > getting the SAP approval) > Yay Paul! My big questions would be... 1. Which site is closest to a major airport and train station? 2. Which one has the best range of accomodation (very low-cost to high-end) 3. Will we need to arrange transport between lodgings and facility? 4. Will we be able to arrange a) fat guest wifi b) beer onsite? > > > Moving onto the bigger part, what sort of conference do we want to put on > in the space? Monday-Friday? Wednesday-Sunday? > Monady-Sunday/Saturday-Friday? How much should be conference sessions, how > much hackathons, how much meetups, how much barcamp / ad-hoc sessions? How > many people will we expect to come for all, and how many for just one day? > Ratio of talks aimed at users, developers, and those interested in open > source business/community/the apache way? > Long weekends are good, but they may cost SAP extra cycles (since they have to bring staff in to handle extra days of security, etc.). I think whether this is a consideration is another question for Paul. > Feeding into this, I know quite a few people go to other community open > source events, and a smaller number help organise them. What works well? > What doesn't work? Who should we be learning from and emulating? > Please look at PyCon. Also? I've been thinking a lot about the pre-conference infrastructure behind UDS (Ubuntu Developer Summit) and its efficacy at transforming their conferences into work sessions via pre-work momentum focused online in the weeks before the event. > > We also need to think about speakers, and generally about how to help get > enough members / committers / nearly-committers along to share knowledge and > teach the apache way. At the big hotel events, speakers have tended to get a > conference pass, hotel nights, and some flight help if needed. People > sharing knowledge in other ways just get cheaper conference passes, but > still need to pay lots for hotel rooms. With an event like this, the > conference fee should be much lower, and with no hotel attached people can > stay nearby wherever their budget permits. How much help do we need to offer > for speakers? And can that work with a lower registration fee, and hence > lower total budget? > IMHO you'll need to at least give speakers free accomodations (as was done with TransferSummit). You may have to help keynotes with airfare. > > And anything else I've missed that we'd need to consider? :) > > Cheers > Nick >
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Some fresh details have emerged about upcoming sports games Fifa 2008 and Madden NFL 08. It seems that EA are fully embracing the Wii's online capabilities.
Madden NFL 08
3,034 news items
Gonzo said:
And then comes NBA Live 08! Hehe.
Chaos said:
Now THIS what I expect from a FIFA game on Wii! Wasn't interested before, but now I've completely changed my mind. Let's hope for a more steady flow of online games on Wii, eh?
Zendalf said:
Wow. I am definitely getting both of these games. What I'll do with madden '07? who cares.
yay wii said:
Once this is out there will be no reason to buy anything other than the Wii.
Scooby Jew said:
Sweet. Some Sony fanboy was dissing on Wii about its "online mess" and sadly, I was actually able to relate to what he was saying. I can't even get the online browser to work because my Wii Shop Channel keeps failing. Maybe it's just my Wii, I don't know, but it's beginning to get me discouraged about the Wii's online system. However, the details about these games' online capability with the Wii is encouraging me.
james said:
These look great but I hope that fifa isn't all motion controls, that would be annoying and hard to do. I hope you can use the buttons as well. YAY it's online! That's got to be good.
cmk said:
Meh, don't like sports. PORT KATAMARI!
Quartz said:
These fail.
shindrA said:
This just made my expectations for brawl ease up a little.
Elementrat said:
I agree with cmk. Katamari looks perfect for Wii. I've never played it, but it just looks like a natural fit.
Zendalf said:
Scooby Jew, it is not your Wii. It is your internet. The Wii doesn't have any problems. Actually I lied, it is best to have the main internet you are using as the first option in the settings. Otherwise it is just your internet. Mine works perfect and we are in another country.
Bryan said:
How can I play against another user in Madden 2008 for the Wii? I know this may be a basic question, but I cannot get the second player feature to work. Thanks for your help.
murda said:
Can you play co-op 2v2 online for Madden 08 on Wii?
The Serious Problem Brewing for Pokemon GO!
A day with Pokemon GO Down Under
Adventure awaits.
Splatoon's Last Ever Splatfest is Coming
And It's Sister vs. Sister
Nintendo President Satoru Iwata Passes Away at 55
Rest In Peace
Nintendo has detailed the return of its World Championship
Do you have what it takes?
Disney Infinity 3.0 Edition Officially Revealed
The Force is strong with this one...
Rumor: Disney Infinity 3.0 Leaked Early
Straight from a Galaxy Far, Far Away...
Mario Kart 8 DLC Pack 2...OH YEAAAAH!
Nintendo should do this more.
The Nintendo GameCube: An Interesting Legacy
Will The Wii U Have a Similar Fate?
Project Ukulele - Possible Hint at Characters
Could it be?
WeSkiStar said:
HA! Don't use the Miis, they look way out of place when everybody else looks like hand-drawn generic kawaii ppl. If you ... We Ski
anjua3754 said:
Oh great news.., Not yet tried rummy tournaments. I usually play rummy variants in silkrummy.com. Now i will try to ... World Rummy Tournament
anjua3754 said:
hi play rummy ... World Rummy Tournament
User said:
hi ... Devil's Third
Raugusto said:
How to get Any Video Games for Free ... Vice President meets with video game industry
Wii's World is not officially affiliated with Nintendo! (but they wish we were).


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I've been playing and producing in the band Lotus for 15 years touring the world. We've sold out venues around the US from Red Rocks in Colorado to Terminal 5 in NYC. I also have a DJ project "Luke the Knife" focusing on disco-house and funk. Now I'm moving into pop production with an emphasis on funk, soul, and disco.
Music Producer and Composer. Multi-Instrumentalist.
Send me an email through 'Contact' button above and I'll get back to you asap.
My credits include
Genres I specialize in
Endorse Luke Miller
Interview with Luke Miller
What type of music do you usually work on?
Funk, Disco, EDM
Tell us about your studio setup.
Pro Tools 10
What other musicians or music production professionals inspire you?
Pharrell, Daft Punk, Bruno Mars, Michael Jackson
Describe the most common type of work you do for your clients.
Writing instrumentals, producing, mixing.