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Design Elements for UML Diagrams
ConceptDraw PRO
Discover the World of Visual Communication
UML Diagrams - Design Elements
UML 2.4 diagrams represent two different views of a system model:
The Rapid UML solution from Software Development area of ConceptDraw Solution Park includes 13 vector stencils libraries for drawing the UML 2.4 diagrams using ConceptDraw PRO diagramming and vector drawing software.
Component Diagrams
"In the Unified Modeling Language, a component diagram depicts how components are wired together to form larger components and or software systems. They are used to illustrate the structure of arbitrarily complex systems."
Activity Diagrams
"Activity diagrams are graphical representations of workflows of stepwise activities and actions with support for choice, iteration and concurrency. In the Unified Modeling Language, activity diagrams are intended to model both computational and organisational processes (i.e. workflows). Activity diagrams show the overall flow of control."
Use Case Diagrams
"A use case diagram at its simplest is a representation of a user's interaction with the system and depicting the specifications of a use case. A use case diagram can portray the different types of users of a system and the various ways that they interact with the system. This type of diagram is typically used in conjunction with the textual use case and will often be accompanied by other types of diagrams as well."
Sequence Diagrams
"A sequence diagram is a interaction diagram that shows how processes operate with one another and in what order. It is a construct of a Message Sequence Chart. A sequence diagram shows object interactions arranged in time sequence. It depicts the objects and classes involved in the scenario and the sequence of messages exchanged between the objects needed to carry out the functionality of the scenario. Sequence diagrams are typically associated with use case realizations in the Logical View of the system under development. Sequence diagrams are sometimes called event diagrams, event scenarios.
A sequence diagram shows, as parallel vertical lines (lifelines), different processes or objects that live simultaneously, and, as horizontal arrows, the messages exchanged between them, in the order in which they occur. This allows the specification of simple runtime scenarios in a graphical manner."
UML Class Diagrams
UML Class Diagrams describes the structure of a system by showing the system's classes, their attributes, and the relationships among the classes.
UML Package Diagrams
UML Package Diagram illustrates the functionality of a software system.
UML Object Diagrams
UML UML Object Diagram shows the structure of a modeled system at a specific time.
UML Collaboration Diagrams
UML Collaboration Diagram depicts the interactions between objects or parts in terms of sequenced messages and describes both the static structure and dynamic behavior of a system.
UML Deployment Diagrams
Deployment diagram describes the hardware used in system implementations and the execution environments and artifacts deployed on the hardware.
UML State Machine Diagrams
UML state machine's goal is to overcome the main limitations of traditional finite-state machines while retaining their main benefits.
UML Timing Diagrams
UML Timing Diagram as special form of a sequence diagram are used to explore the behaviors of objects throughout a given period of time.
UML Interaction Overview Diagrams
UML Interaction Overview Diagram schematically shows a control flow with nodes and a sequence of activities that can contain interaction or sequence diagrams.
UML Composite Structure Diagrams
UML Composite Structure Diagram shows the internal structure of a class and the possible interactions at this structure.
How to Create a UML Diagram
The ConceptDraw Rapid UML solution provides a set of special tools for creating UML diagrams. Run the ConceptDraw STORE, select the Rapid UML Diagrams solution and click "Install".
Result:Using the RapidDraw technology to create diagrams allows you to make very complex diagrams quickly and easily.
Apple® OS X 10.10 or later
Microsoft® Windows® 7/8.1/10
|ConceptDraw PRO


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I have a domain environment. we have a computer name policy but some times while creating the computer names my administrators by mistakenly create a different type of name. which create a problem. I wanted to fix the computer name standards. Please suggest
3 Replies
Nov 22, 2011 at 1:40 UTC
Are you looking to fix the policy that guides making the name, or fix the names in Active Directory? To fix the name in AD, just rename the computer.
Nov 22, 2011 at 9:04 UTC
From your workstation with the AD tools installed just use:
netdom renamecomputer \\oldcompname /newname:newcompname /usero:domain\adminname /passwordo:* /userd:domain\adminname /passwordd:* /force /reboot:10
You can remove the /reboot part, but the name change will not fully take affect until the computer is restarted - this will reboot the computer in 10 seconds.
Nov 22, 2011 at 9:51 UTC
FixIT Chiltern is an IT service provider.
For windows 7 PCs log in as an administrator. Right click my computer, choose properties. At the computer name & domain settings, on the right hand side of the screen is a blue link to "change settings". To rename the computer click on the "change" button and off you go.
Personally I like to put it in a workgroup (so it's no longer on the domain) change the name and then put it back into the domain, but I'm not sure this is required.
You will need to reboot to apply changes.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.

subset: commoncrawl


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Learn more about D.J. CONTRACTS (WEYMOUTH) LIMITED. Check the company's details for free and view the Companies House information, company documents and list of directors.
Know about every new company document that is added!
Take advantage of our watch this company feature free of charge and have notifications sent directly to your inbox. Whenever a new document appears on this website, or if their particulars change, you will be immediately informed about such changes. To monitor these changes, all you need to do is click on watch this company.
|Fixed Assets
|£ 2,517,106
|Tangible Fixed Assets
|£ 2,517,106
|Current Assets
|£ 3,694,351
|Provisions For Liabilities Charges
|£ 903
|£ 2,791,258
|Shareholder Funds
|£ 6,102,790
|Profit Loss Account Reserve
|£ 4,055,931
|Revaluation Reserve
|£ 2,028,857
|Called Up Share Capital
|£ 18,002
|Net Assets Liabilities Including Pension Asset Liability
|£ 6,102,790
|Total Assets Less Current Liabilities
|£ 6,103,693
|Net Current Assets Liabilities
|£ 3,586,587
|Creditors Due Within One Year
|£ 107,764
|Cash Bank In Hand
|£ 903,093
|Par Value Share
|Deferred shares of £1 each
|Number Shares Allotted
|£ 18,002
Information about the Private Limited Company D.J. CONTRACTS (WEYMOUTH) LIMITED has been prepared for information purposes only. It is not intended to be nor does it constitute legal advice. This is public information provided by the official company register.


text:
Whistler Peak Lodge superior studio suites feature a queen bed; a double murphy bed; a kitchenette complete with coffee maker, kettle, toaster, cookware, dishware, cutlery, microwave, cooktop (no oven), and mini fridge; along with a dining area and seating for two.
Each superior studio suite also includes complimentary wireless internet, cable, an air conditioning unit, an iron and ironing board, a hairdryer, a clock radio, and a private fireplace to relax in front of.
Square Feet: 344-371
Images are representative of a particular rental unit and cannot be used as a guarantee for all rental units.
You can download a detailed Whistler directions map for this accommodation rental property location in advance of your arrival at the resort. This map is provided in JPG format so you can save it on your mobile handheld device and use it during your vacation. Download Directions Map
ResortQuest Whistler provides excellent rental accommodation in Whistler village and the surrounding areas of the resort. You can browse the entire selection of great rental properties online and also plan your entire vacation trip using the very detailed travel guide section.
Whistler ski-in ski-out vacation rental properties are great for any holiday trip to the resort. ResortQuest Whistler offers a great selection of deluxe accommodation rentals available at the base of both Whistler and Blackcomb mountains. Book the perfect Whistler rental lodging online or over the telephone and enjoy all that the resort has to offer your entire travel group. Choose from a diverse selection of rentals that range from studios to 5+ bedroom chalets. View the property catalogue online.


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New Law Imposes Strictest Fracking Ban. Oil drillers in California have for years used hydraulic fracturing, or fracking, with very little oversight, according to a new Associated Press report. But now, people in the state are taking notice, and California legislators are considering a new law that would impose some of the strictest fracking regulations in the nation.
It seems the California Department of Conservation's Division of Oil, Gas and Geothermal Resources or DOGGR has done little to regulate fracking, partly due to budget constraints. The agency can't even say where or how frequently fracking is performed in California. According to the Associated Press, once an energy company has a well permit, it's free to use fracking or any other technique to access the oil without further reporting in the state.
People Claim Fracking Caused Problems
It's known that fracking is taking place in Santa Barbara , Monterey, Kern, Ventura and Los Angeles counties, but there's no way of knowing if drillers are using it anywhere else. According to the Associated Press, people living in Baldwin Hills, Los Angeles County, have claimed that fracking there has caused health problems, as well as property damage.
The new California legislation, if it becomes law, would not only regulate fracking, but make companies disclose the chemicals they use in their fracking fluid, the amount of water they're pumping and where they are fracking. The bill has already passed the state Assembly, and has been introduced in a Senate committee.
Meanwhile, the New York State Assembly has passed a bill that would extend a fracking moratorium there for at least another year. The new moratorium bill, which passed the Assembly 91-46, would cover fracking for oil as well as gas, and would cover vertical drilling using hydraulic fracturing at until July 1, 2012.
A current moratorium on high-volume, horizontal hydraulic fracturing in New York State is scheduled to expire on July 1. The new moratorium bill still needs to make it through the state Senate, where a narrow Republican majority makes its fate uncertain.
Need Legal Help Regarding Fracking Ban?
The personal injury attorneys at Parker Waichman LLP offer free, no-obligation case evaluations. For more information, fill out our online contact form or call 1-800-YOURLAWYER (1-800-968-7529).


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CD Designs Case Studies
Browse our pattern imprinted concrete driveway case studies:
Please browse the case studies below to view examples of our work:
This project consisted of three phases of work, decking and fencing at the rear of the property, and pattern imprinted concrete on the front driveway. To start with the old fenc..more
The Padiham project was installed in September of this year. We installed Pattern Imprinted Concrete to the rear of the property. Originally a small space, this back yard was trans..more
This project was installed in early September of this year. The customer wanted a transformation of both the back and the front of their property, with a new pattern imprinted driv..more
The Bowdon project was installed in March of this year. We originally posted a time-lapse video of the landscaping that we did, and whilst we were there we also installed pattern i..more
This particular customer approached a former customer for our details after being impressed by our work, which you can see here. The customer wanted a transformation of both the ba..more
The Holywell project took place in an extremely rural part of North Wales. The customer wanted a transformation of both the back and the front of their property with a new pattern ..more
This customer was drawn to our company from us being part of The Guild of Master Craftsmen. The customer wanted a transformation of the front of their property, with the space bei..more
Due to the volume of traffic that was expected on the site, our specifications were as with previous drive-thru's changed slightly from our usual driveways, with 7 inches of c..more
First the existing driveway was broken up and dug out. Next a trench was dug on the left hand side of the drive for the new drainage system. Pipework was laid in this trench, which..more
Installed in November, this particular customer asked for our details from a former customer of ours after being impressed by our work. They wanted a transformation to both the bac..more
Due to the volume of traffic that was expected on the site our specifications were changed slightly from our usual driveways, with 6 inches of concrete and steel reinforcement mesh..more
This tarmac driveway was found to be lackluster by the owners of the property. They wanted something that was more aesthetically pleasing but didn't want pattern imprinted con..more
This half-flagged, half-concrete driveway and patio had over time become susceptible to weed growth and was very much overgrown. The flags and concrete were primarily removed and t..more
The blocks were primarily removed and the perimeter was shuttered allowing us to gage our levels and grade off. New deco drainage systems were fitted around the front and gable end..more
The Grand Ashlar effect does not look out of place on this vast and stylish driveway, with the wide textured borders providing a definitive frame for the pattern itself, it simply ..more
This charming back street had lost some of its attraction. Its mix of cobble and un-decorative concrete had taken the appeal away from this secluded Dickensian street. New Aco drai..more
Once the paving stones were removed the driveway was excavated along with part of the front garden. Levels were then set and shuttering timbers were used to form the shape of the d..more
The customer wanted a planter to be constructed from stone and requested the colour of the stone contrast well with the colour of the pattern imprinted concrete. A lighter grey was..more
This was the second project in July where we were set a similar task, to provide a low maintenance and aesthetically pleasing patio which would incorporate a ramp with level access..more
Firstly the job area was excavated and the frame of the decking was erected. The Pattern Imprinted Concrete area was then prepared around the decking, and aco drainage was fitted a..more
This cobbled set driveway was prone to moss growth and flooding, and was not level or even. The customer wanted something that was low maintenance, free of trip hazards and that c..more
This landscaped patio and raised patio area featured a variety of interesting features. A pond area was formed and brick walls erected to define the pond area and the raised patio ..more
The KFC restaurant was relocated as part of the large Tesco redevelopment in Walkden. The concrete pattern selected was Walkway Slate in Classic Grey. The pattern imprinted concret..more
As you can see from the before photos this was a drap and driery patio area with standard 3 x 2 grey flags which are grey and not very attractive. We have brought this patio area ..more
This Driveway has featured on our website from the start. Installed in 2001, it was one of the first driveways we installed working for ourselves Complete Driveway designs. Mr Derb..more
This was one of our larger jobs and again the customer was wanting a company to take on all their needs. Not just a driveway was required, the whole front of the property was to be..more
As you can see from the before photographs Mr Murray had a block paved driveway which did not stand up to the test of time. Although this driveway was only three years old, it had ..more
Upon visiting Mr Zaldats, it was clear he knew exactly what he wanted, and been messed around by a lot of people in the industry. We tackled the job the same as any other, in a pro..more
This customer called Complete Driveway Designs as the company that orignanally installed his pattern imprinted contcrete driveway was no longer in business and he wanted to go with..more
This installation in Greenmount was a fairly big job. With concrete at the rear of the building as well as a pattern imprinted concrete driveway, it came to around 80m2 of pattern ..more
For this project the customer wanted to secure the premisis with installation of the new driveway.
Brandlesholme case study from October 2008, a pattern imprinted concrete driveway and matching pattern imprinted concrete path to the house entrance with an attractive diamond Ashl..more
This project was undertaken in May 2009, the customer wanted to create a well presented drive inorder to compliment the rest of the landscaped garden.
As this project unfolded we took walls, laying turf and making good flaged area. Once again giving the customer a complete package. Leaving the customer with enough scope to person..more
Mr and Mrs Martin are very well known to CD Designs as they have started a trend on Benbecular Way, Urmston. They were the first to contact CD Designs via an email through our web..more
This being the second driveway on Benbecular Close, we were keen on making our first impression last.. As you can see, we had the same high quality intentions as their neighbour..more
As the customer wanted to keep his garden and parking wasn't an issue in this case, we decided together that a long curvy pathway leading to the front door would complement hi..more
The driveway in this project was the last piece in the jigsaw to the house renovation. As you can see it complements and finishes the house nicely. Due to the renovation, the house..more
Newly retired Mr and Mrs Quigley decided to transform their old drive for a brand new pattern imprinted concrete driveway after taking up their new hobby, motorhoming. They were lo..more
This was a pretty big installation, involving an impressively long driveway as well as the installation of some pattern imprinted concrete paths. All in all it came in at 90m2 of c..more
This was quite a big job, involving quite a large area of pattern imprinted concrete, approx 72m2. At the end of the job the client had a pattern imprinted concrete driveway to be ..more
This is a pattern imprinted concrete driveway which we installed in Heywood. It involved a few nice little features, along with our usual high standard of pattern imprinted concret..more
This was quite a large installation, covering about 80-90m2 of pattern imprinted concrete. It also involved a few additional features, which you'll see as you click though the ca..more
The owners of this property had decided they wanted to open up the exterior of the house all the way round from the drive to the recently extended back patio. The homeowners have n..more
This was another job on Dee Drive in Kearsley. We often find that we get called back to streets that we've visited before, because neighbours get interested in the quality of the..more
This was a nice medium sized installation, with about 50m2 of pattern imprinted concrete driveway to be installed. There were a few nice little elements that will point out as the ..more
Well, this was a pretty big job; 130m2 of pattern imprinted concrete all in all. We installed two pattern imprinted concrete driveways side-by-side, all as part of one job for one ..more
Previously the driveway of this house was block paved which looked unclean, uneven and was sinking in places which was a shame attached to a house of this stature. Once we started ..more
After conversations with the customer it was clear there was an underlying problem with his current driveway. He couldn't fit his cars comfortably on the drive, and when parke..more
This Bury job wasn't the smallest that we've ever done, clocking in with 55m2 of pattern imprinted concrete at the front of the property and another 65m2 at the back.
Well, this was a big job! 180m2 of pattern imprinted concrete all together. There were also a number of interesting features that were part of the design. As you'll be able to se..more
Patio areas can be so important in the summer months. This patio has been transformed into an area which is 100% usable. It looks great with its feature curves complementing the pa..more
This driveway has kept its same general size and shape, but with a few cd designs gentle curves to give a more subtle look. The horrible red 3x2 flags have been removed, and we hav..more
When we first arrived on this driveway nothing existed apart from a patch of overgrown grass used as a parking space. Here we have created a beautiful driveway and pathway which le..more
The elderly couple in this property wanted a maintenance free solution to their ever needing front garden. They required an area to be both asthetically pleasing and somewhere to h..more
This was a classic case of a block paved driveway that had sunk everywhere, unfortunately we do not have any pictures from before however here are the completed pictures... The dri..more
Grasmere, Ashton-Under-Lyne. This was a relatively simple installation; the client didn't require any of our other services, just a simple pattern imprinted concrete driveway. Oh..more
We did two installations at this property in Bolton, surfacing both the front and back of the property with pattern imprinted concrete. Rather than hit you with one huge case study..more
This case study shows the work we performed at the rear of a property on Lynstead Avenue in Bolton. There's a separate case study detailing the pattern imprinted concrete install..more
This job was a bit closer to home, in Bury, where our office is and it was slightly more involved than the usual pattern imprinted concrete driveway installation. Along with laying..more
This is something a bit special. Well, all of our installations are special, but this one's extra-special. At this property we brought the concrete indoors, and laid an interior ..more
This was another job in Bury. In fact, it was a return trip to this property for us; we'd previously installed a full pattern imprinted concrete driveway for the owners. Impresse..more
At this job over in Chadderton we had some pretty cold weather to contend with, as you'll see later on. But cold as fine, as long as it's not too wet, so we got on with it. The..more
Another job around the Chadderton area, a 40m2 pattern imprinted concrete driveway, incorporating rebuilding the driveway pillar at the end of the driveway wall.
This was quite an involved installation. Although it only covered 55m2, there were a few of those little details that make pattern imprinted concrete driveways really visually appe..more
CD Design installed a pattern imprinted concrete patio (covering approximately 100m2) 4 years ago. We were asked back to design and install the complete driveway in pattern imprint..more
Problem: Having had severe weather over the last couple of winters many block paving, tarmac and pattern imprinted concrete driveways have suffered. This particular pattern imprint..more
Problem: The Water Main underneath the concrete had burst. This meant that the service company were required to break out a section of the existing pattern imprinted concrete to ac..more
Problem: After only a few years after installation this block paving had seen a huge development of weeds. The blocks were soiled and dirty and the area looked unpleasant, despite ..more
The driveway and patio was completed in august 2011. Demolition of the front wall and full excavation of the front turfed area was the starting point. The wall was rebuilt by ourse..more
This job incorporated the construction of a new wall around the left perimeter of the front drive and a new fence along the right hand side. The driveway integrates an ashlar slate..more
This project was a exciting one to be involved in, particularly when you look back at how the driveway was before. Fencing was erected to the rear of the property and a patio insta..more
This project was themed around accessability. An access ramp and steps were formed which would lead from a top patio to a lower patio and garden area, and a hand rail was installed..more
Using KL blocks the form of the patio was shaped and installed with the pacific boardwalk pattern. To accompany this artificial grass was laid. The inspiration for this was the pro..more
Two customers decided they both wanted to renovate their driveways and collectively add value to their properties. In this case both driveways had different levels so had to be spl..more
The Herringbone brick effect was chosen to match the customers existing block paving. However, the customer can be assured that the Pattern Imprinted Concrete will not sink as his ..more
The area surrounding this property was opened up immensely with paths linking the driveway to the patio, and the patio to various parts of the garden, enabling easy access and crea..more
The flags were replaced with pattern imprinted concrete to give a good looking, low maintenance patio. Platinum silver was chosen for the colour, as it matched the houses window fr..more
The customer decided that she wanted a predominantly decked area with the incorporation of a shallow step and a 10 metre squared area of pattern imprinted concrete at the foot of t..more
This project is from 2010, but as we were doing a job recently on the same street we called round to see if our customer was still enjoying their driveway. They were still delighte..more
Installed in Mid June 2012, we were installing a job on the same street in May 2012. This was a project that developed from a previous customer forwarding our details to a new cust..more


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Simplicity 3056; ca. 1939; Misses' Blouse. Any one of these blouses with be a perfect complement to your suit. Style I is yoked at front shoulders and at back and has a square neckline. It buttons at front and is finished with a wide belt at waist; short or long sleeves. Style II is decidedly feminine with its frilled, ruffled jabot and tie collar. Sleeves are short.
Featured in April 1939 Simplicity Prevue
Links to reviews/blog posts Edit
Sources/Vendors Edit
Gallery Edit
[insert your photos of this pattern made up]
Wishlist Edit
[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


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COVER REVEAL GIVEAWAY - Taming the Curator
Book releasing on September 14th!!!
Cover designed by Susan of Wicked Women Design
To celebrate - a $20 Amazon giftcard GIVEAWAY
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Book synopsis:
Chloe Erikksen, museum worker by day and burlesque singer by night finds her world completely turned upside down as her life is taken over by a man who most women would say was unattainable... untamable.
When she is forced to move in with him will she find that he is just what she needs or will he be too much to handle for a woman who has lived her whole life alone, feeling unloved?
What is the man's motive behind controlling her? Is it because he simply doesn't want anyone else to have her? Or has he finally found the one that has changed him... tamed him?
Have you read book 1 - Reclining Nude in Chicago?
Not required to read before Taming the Curator
but it's fun to read the connections!!!
Available NOW


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Science fiction and fantasy stories about Japan by the multiple-award winning author and New York Times best seller Catherynne M. Valente. A collection of some of Catherynne Valente's most admired stories, including the Hugo Award-nominated novella Silently and Very Fast and the Locus Award finalist "13 Ways of Looking at Space/Time," with a brand-new long story to anchor the collection.
Bookwire is a mobile app for your iPhone that gives you the ability to scan a barcode
or enter ISBN, access book records and add titles to wish lists.


text:
Help writing narrative essay
Nélissen destined to medical career inscr it the role of students A ersity Ghent, he conquered with great distinction, degree but showed, chemistry laboratory which has managed the lab, such an aptitude for chemistry study professor Th. Swarts, urged him to devote ly excluded chemical sciences offered him as preparer Government propose courses. Nélissen accepted the offer with alacrity October was appointed provisionally, general chemistry course preparer this appointment became writing pay someone to write my paper help for college students defines e October.
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text: Home Gallery Print (Slideshow) Jägermeister 56 Parts Best as One Jagermeister Illustrates Its 56 Ingredients With Handmade Wood Puzzles Laser-Cut Puzzles Were Photographed to Create Print and Outdoor Ads Published on Mar 04, 2015 Editor's Pick This beautifully-illustrated print and outdoor campaign for German liqueur Jägermeister was created by Deutsch, N.Y., which worked with three artists to bring the brand's 56 ingredients to life. Each illustrator created a template that was then turned into a 56-piece "wood puzzle" illustrating the different ingredients. The wood was laser cut, then etched, hand-tooled or hand-painted, and made into puzzles. They were then photographed for the campaign, which is aimed at informing a U.S. audience about the brand's heritage. The 80-year-old recipe is based on a mix of different herbs, spices, fruits and roots. The artists are Seattle-based Olivia Knapp, whose style is influenced by European line engravings from the 16th to 18th century; California art group DKNG, who have worked with rock musicians such as Jack White and the Dave Matthews Band; and Stephane Caiser of Yeaaah! Studio Paris, a French graphic designer and illustrator. Rate this Ad You must be registered to rate the ad. Please Login or Register Now About CreditsDateMar 04, 2015Agency:Deutsch New YorkClient:Jägermeister Tagsalcohol alcohol CategoryOOHPrint Ad Latest Creativity News on Ad Age Agency Brief: Where Is Everybody? Gallegos United Has a New CCO, Arnold Hires Alfson, Low Joins Ogilvy Beijing 'I Have a Huge Idea:' Wyclef Jean Wants to Work With Brands Related work WATERisLIFE: Hidden Dangers Deutsch New York Booking.com: Kindergarten Deutsch New York Busch: BUSCHHHHH Deutsch New York


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July 19, 2010
Photo by Derick G
Miami based Inked Productions recently launched a couple baby sized and female tailored products and they did a shoot with local favorite Derick G. And here's what they came up with.
Also: Inked Productions celebrates their store front grand opening on Saturday July 24th. Their storefront is located at 4467 SW 71 Avenue – Miami, FL 33155. Click here for flyer.
Click below for the baby shoot photos…
CategoriesMiami Fashion


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Combating Menopausal Weight Gain
Menopause begins during late forties or early fifties due to poor ovarian perform. Anti-depressants are often prescribed to take care of signs akin to depression, mood swings, and anxiousness attacks. Symptoms of despair are characterized by feelings of worthlessness and self-reproach, lack of concentration, emotions of doom, fatigue, uncommon sleeping patterns, excessive eating patterns and suicidal thoughts. Over-the counter merchandise are often hrt treatment after menopause unsuccessful in treating cystic zits and prescription oral and topical antibiotics are wanted. People have grow to be accustomed to speaking about bio-similar hormone substitute therapy (BHRT) in menopause and anti-growing old medicines versus artificial massive pharmaceutical merchandise like Prempro from Wyeth. If HRT incorporates progesterone, then there may be an increased risk for breast most cancers.
Follow-up studies, nonetheless, have steered that HRT could also be acceptable for brief-term use for certain women. Anxiety or despair or, usually, a combination of each might not end result menopause and hrt guidelines immediately from the menopause; extra importantly, these could also be signs arising from the non-public life of the person. Your physique can stay in perimenopause for many years earlier than reaching precise menopause.
These choices are way of life modifications, natural and different dietary supplements, bio-an identical hormones, medications, or HRT. Some of the changes throughout menopause will be treated by providing replacement estrogen instead of the hormone which is no longer produced by the body. Exercise throughout and post menopause has the additional advantage of maintaining your bones strong, strengthening your heart and burning energy for managing your weight that are all major considerations as your estrogen steadily wanes. Think hard about the moral and medical hazards of HRT before you commit your self to an uncertain future, one that you just would possibly remorse. The Environmental Protection Agency in the United States has determined that utilizing bleached espresso filters alone can result in a lifetime publicity to dioxin that exceeds acceptable risks.
After the Women's Health Initiative Study launched its findings about the risks of synthetic hormone alternative remedy (HRT) in July 2002, medical menopause hrt alternatives doctors abandoned women's hormone health for misinformation, confusion, antidepressants and birth control pills.
It's a bit harder to predict breast ache in case you are in peri menopause and you might be experiencing irregular intervals. Research has shown allergies are often triggered or intensified by natural physique transitions and cycles reminiscent of puberty, pregnancy and menopause. Menopause is the time period that refers to the cessation of the menstruation cycle of a girl. Also, the usage of vitamin A, contraception pills and antidepressants has been known hrt australian menopause society to cause hair loss. A woman is said to have finished menopause when she has gone a full year without a menstrual interval or any menstrual spotting. This is normally used in combination with oestrogen in HRT remedy and UK on-line physician Dr Matt can discuss you through your symptoms essentially the most suitable choices. It's important to have yourself checked by your primary care physician for either osteoporosis or arthritis.
There are some reports that consuming less pink meat and pork reduces fibroids and some women have reported success with becoming vegetarian. Treatment of Pregnancy signs may be one thing to ease your upset abdomen, weight loss program modifications, and monitoring by your physician. After the menopause, too, lowered hormone levels often go away hair just a little thinner.
However you choose to journey via the menopause, whether with HRT or bio-similar pure hormones, it helps to know just what your choices are and exactly what hrt treatment after hysterectomy is in the formulation you are utilizing as a way to make an informed alternative.
Author: Dilan BeliThis author has published 2445 articles so far. More info about the author is coming soon.


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Lassiter Learns How to Bend
Pairings: Shawn/Lassiter
Warning: Shassie Slash. Takes place after Lassie Did A Bad Bad Thing. Contains spoilers for that episode.
Disclaimer: All publicly recognizable characters, settings, etc. are the property of their respective owners. The original characters and plot are the property of the author. The author is in no way associated with the owners, creators, or producers of any media franchise. No copyright infringement is intended.
Summary: Lassiter is alarmed at finding himself attracted to Spencer following the Drimmer incident. He visits a friend in San Francisco, looking for advice, but Spencer has tailed him. Lust overtakes them in the gayest city in the world, but can their relationship survive returning to Santa Barbara?
Note: I had not visited San Francisco when I wrote this story and relied on websites to give me a sense of the Castro district. Some of the bars mentioned are now closed, and some have changed names and/or clientele.
In the name of Sweet Lady Justice…why does this have to be happening to me now? Lassiter wondered. It wasn't enough that Ernesto Chavez had been shot in his custody, or that he'd been framed for the murder and nearly lost his career. No, now his mind and body were rebelling against him, indicating the beginnings of an inevitable decline into madness and dementia. In a way, the whole thing could be blamed on former detective John Drimmer. It was his idea that Lassiter's fake suicide note should portray him and Spencer as lovers. That idea had somehow wormed its way into his subconscious and laid eggs.
At first he'd become focussed on whether people thought the idea was credible. His discussion with O'Hara over lunch in the break room had not put his mind at rest.
"Nobody would have believed that fake note, right?" He frowned down at his Enchirito instead of looking at her directly.
"Maybe," she said around a mouthful of chicken taco, then swallowed. "Drimmer was pretty clever. The note would be in your handwriting, and it would explain why Shawn's always been so uninhibited with you around the station. I mean the guy sat in your lap. He doesn't do that to me."
"I could maybe—maybe—see people thinking that Spencer was gay, but me? Would you have bought that?"
"Well…." O'Hara looked around the room as if desperate for something to change the subject. "Our job could be said to attract people with certain repressed impulses, Carlton. There's a reason one of the Village People is a cop. There's the uniform, and the homosocial atmosphere—not every station has as many women as ours does, you know."
"But I've been married. To a woman."
"So was Elton John. And Rock Hudson."
"Okay, fair enough. But even if I were some sort of late-blooming homosexual, why would I choose Spencer of all people? He's irresponsible, he's socially embarrassing, and he's an attention sponge the likes of which I have never seen."
"Opposites attract?" While Lassiter continued to frown at his lunch she continued. "Look, Drimmer was just grabbing for the first thing he thought would make people uncomfortable and not look too closely at your deaths. Let's move on."
But Lassiter wasn't moving on. In fact he was kind of fixated. He kept going over in his mind all the reasons that this imagined relationship was absurd. But instead of putting his mind at rest it was reminding him of a line from Hamlet he'd learned in college, while dating an actress: "The lady doth protest too much, methinks." It was not reassuring.
It wasn't that he hated Spencer. Lately he'd developed quite a respect for him. Sure, Spencer was annoying, but he was good at what he did. Much of what he did was ridiculous, but whatever was behind the façade was solid. Plus, Spencer had been on his side through the whole Drimmer fiasco, and even the Chief and O'Hara had been giving him some looks on that one. Spencer had trusted in his innocence, and that meant something. Exactly what it meant, he wasn't sure.
Since shooting Drimmer he'd been having a recurring dream in which he hadn't reached the gun in time, or had plunged his hand into the bowl to find nothing but peanuts. The dream ended with Drimmer shooting Spencer, and Lassiter woke in a cold sweat with a sense of anger and loss that felt out of proportion to the situation. Several criminals had tried to kill Lassiter. It was part of the job that every police officer accepted. He didn't take it personally. That Drimmer had tried to kill Shawn enraged him in a way that was unexpected and tinged with a protectiveness that went beyond his basic duty to the general citizenry of Santa Barbara.
Maybe, he thought, I've got post-traumatic stress. True, he didn't have any symptoms other than the nightmares and the obsession, but it was a condition that medicine was still trying to understand. Just in case it wasn't PTSD he'd forced himself to return Spencer's blue plaid shirt, which he'd borrowed during their investigation into the Chavez shooting. He had made a point of not smelling it before tossing in the washer, but it bothered him that he'd wanted to.
It didn't help any that Spencer was clinging to him like a piece of Velcro. He kept showing up with presents. He brought him lunch and coffee. He 'just happened' to have an extra almond croissant. He seemed to be standing even closer to him than normal. And every time Lassiter had looked he'd caught Spencer watching him with those disturbing eyes of his. Lassiter firmly believed that eyes should be a specific colour, not vary from blue to green to hazel according ones clothing choice.
While frustrating, Spencer's behaviour made a kind of sense. Being that close to getting shot in the head was probably a new and upsetting experience for him. He'd been treating police work as a hobby, and now it had almost gotten him killed. And since Lassiter had been pretty heroic under the circumstances, it was understandable that Spencer felt safer around him. Lassiter actually had to stifle the impulse to reach out and comfort him sometimes. But such an attempt would be awkward and likely to be misunderstood, he told himself. He was pretty sure that if he just waited it out Spencer would get back to his carefree irresponsible self.
And then there had been the Cruickshanks case. A woman had been found bludgeoned to death in a storage room at the back of her store. The room was a warren of narrow aisles between towering shelves of boxed stock. Lassiter had been recording the scene of crime details in his notebook. Spencer had been spinning around like a dervish, muttering something about the Wicked Witch of the West.
O'Hara approached, carrying a bloody shoe in an evidence bag and said, "Can I get through, please?" Lassiter pressed up against the shelves to let her by, and Spencer had done the same but instead of moving next to Lassiter he'd squeezed right on top of him. O'Hara was momentarily bottlenecked, but fought her way free and out to the car. The problem was that in those few seconds, Spencer's backside pressed firmly against Lassiter's front side. And in the immortal words of George Costanza, it moved.
Since that moment, every second Lassiter spent near Spencer had been torture. At first he was preoccupied with the immediate repercussions. Had Spencer noticed? Surely not. If he'd noticed he'd have said something smart-mouthed, like "Is that a nightstick in your pocket?" He'd given Lassiter a look, though. He was certain there'd been a look. It wasn't confusion or disgust or annoyance. It was almost as if he'd never met Lassiter before and couldn't figure out how he got into the store. That, of course, made no sense. As time passed and Spencer didn't mention the incident, his anxiety grew. Clearly he would mention it at some future point, probably when Lassiter was surrounded by co-workers. Maybe in front of the Chief.
Lassiter had combed through his mind for some explanation of this physical reaction. It doesn't mean I'm attracted to Spencer, he'd told himself. It's been so long since I had sex that I'd become aroused by a strong breeze. Maybe I was responding to O'Hara. She's an attractive woman. Or maybe this is a suicidal drive of some kind leading me to sexually fixate on the person who could most easily ruin my career. None of the explanations offered any comfort. He found himself wishing that he'd had some youthful same-sex exploration to fall back on. Maybe then this sudden infatuation wouldn't be so alarming. As it was, the closest thing he'd had to a gay experience was having a poster of Steve McQueen from The Getaway on his wall for a year and a half in junior high. The Cruickshanks incident left him hyper-aware of Spencer's presence and vaguely horny every time the psychic was around. It was as if the fake suicide note had become a prophecy that Lassiter's body was determined to fulfil.
Worst of all, Lassiter couldn't be sure that Spencer wasn't reading his mind—or whatever it was that he did. He had always been touchy-feely around the station, particularly when he was in the grip of a 'vision.' But in the week after the Cruickshanks case each touch seemed to taunt him with some secret knowledge. Spencer had touched Lassiter's face and held his hand there for what seemed like forever, claiming he saw visions of yellow brick roads and tiny little people. He'd placed his hand on Lassiter's chest and suggested he come to Emerald City with him and ask the Wizard for a heart. It was alarming and arousing, and more than a little confusing. He'd only seen the Wizard of Oz once, as a child, and he didn't remember much beyond the singing munchkins and the terrifying flying monkeys. Spencer's whole song-and-dance made more sense later, when they had arrested the victim's neighbour, who Lassiter had to admit, did kind of resemble Margaret Hamilton.
Despite being a fraud and a flake, Spencer got results. But the kind of results he'd been getting lately were entirely too problematic. Maybe if Spencer kept a normal distance, he thought, the sexual tension could re-submerge into whatever dark recess of his psyche it had come from.
He tried verbally rebuffing Spencer, but his orders to stay off his desk, stop touching him, or remain outside the imaginary hula-hoop of personal space were ignored. Most recently, Spencer had walked up casually behind him, placed both hands on his shoulders, commented on how tense Lassiter was, and started massaging him with surprising skill. Lassiter's physical response was to lean into the massage, but his mental response was anger that Spencer had again ignored his boundaries and did so in full view of his co-workers.How many of them are thinking Drimmer had it right? He wondered. Hell, even I'm wondering if he had it right.This kind of speculation could undermine his authority in the station. This whole Spencer thing had to stop now.
Lassiter spun in his chair, grabbed Spencer by the back of the neck and pulled him off to a secluded corner near the stairs. There was no reason everyone had to see this.
"You just don't get the message, do you Spencer?" Lassiter backed him up against the wall and leaned in. "This is my workplace," he said through gritted teeth. "I'm in a position of authority here. Why can't you just respect what I do, even if you can't respect me as a person?"
Shawn was smiling, as if the whole thing was a joke. I should have known this couldn't be solved without violence, Lassiter thought. He grabbed Shawn by the biceps and slammed him against the wall. That was a little too hard,he said to himself, but then stifled the thought. Better too hard than not hard enough.
"Leave. Me. Alone." Lassiter looked Shawn in the eyes so he couldn't misunderstand or laugh off the message. He saw surprise, and a large helping of hurt, but Spencer wouldn't get the message if it were less blunt. "Stop following me. Stop touching me. Just stay—away." Lassiter punctuated this last word with a second slam into the wall. This time Shawn actually winced, and Lassiter felt guilty as he turned and walked back to his desk, leaving Spencer rubbing his bruised arms and looking after him with confusion, surprise and something Lassiter might have recognized as curiosity.


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Once you decide the next step is to buy a houses for sale, whether it be your first or your fifth, you should get a home loan arrangement in theory. This particular agreement, created between you and a lender, describes how much money you can obtain to get a mortgage by way of their firm. How can this be of great importance? With this contract, you'll find you are in a much stronger position when it's time to barter the buying price of the home. The real estate agent is totally aware of what you can obtain and you will have an advantage over those who haven't carried out this. Individuals often fail to take this task because they're concerned it will hurt their very own credit score. This isn't the case, seeing that 2-3 credit score searches are usually not going to produce much of a difference to an individual's credit rating. The seller also understands you are ready and that the transaction will go through when you make a deal. This provides you an advantage over potential buyers who do not have a mortgage arrangement in theory. The seller may agree to take a price reduction from you in order to prevent the inconvenience of working together with somebody for a long period of time only to discover they can't acquire the funds needed to purchase the house. These are merely a few of the many advantages associated with taking this move. For additional information on the property shopping process, learn about it here. You will find the information you will need at each and every stage of the procedure. Obtaining a home loan arrangement in principle is simply one part of the procedure. You need to make certain you fully grasp all steps to help make the house buying procedure easier.


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text:
|Publication number
|Publication type
|Application number
|PCT number
|Publication date
|May 4, 1993
|Filing date
|May 17, 1990
|Priority date
|May 24, 1989
|Fee status
|Also published as
|Publication number
|Nicholas J. Allen
|Original Assignee
|Allen Nicholas J
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (21), Referenced by (61), Classifications (16), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention relates to a disposable mixing device, e.g. formed of plastics materials, for packaging two components which are to be mixed prior to use. The invention finds particular application in packaging and storing pharmaceutical compositions, advantageously in unit dosage forms.
It is known to store components which are to be mixed prior to their use in an ampoule with a partition dividing the two compartments For example, French patent No. 1,054,170 published Feb. 9, 1954 discloses containers or ampoules which are compartmentalised in various different ways to facilitate storage and subsequent mixture of two components prior to their use. FIG. 9 in particular discloses an ampoule containing a powdery material in one compartment and a liquid in another compartment, the two compartments being separated by a partition wall which can be made to give way under finger pressure, thereby allowing contact between the two ingredients.
British patent No. 670,314 published Apr. 16, 1952 also discloses a divided ampoule construction having a partition rupturable by finger pressure on either half of the ampoule Such a structure may be formed by local heating and compression of the area where the partition is to be formed, thereby sticking but not fixing the walls of the ampoule together.
In these known containers, there is a danger that liquid contained in one of the compartments may seep around the partition or closure member into the other compartment; this may adversely affect the storage properties of the material contained in the second compartment. Also, if a hygroscopic powder is contained in the second compartment, it may be difficult to detect whether any liquid seepage has occurred.
According to one aspect of the present invention, there is provided a device which comprises a generally cylindrical plastics container sealed at its ends and having a compartment intermediate said ends, defined by temporary seals, thereby dividing the container into three compartments, wherein that compartment of said container adjacent to one end thereof contains a first material and that compartment of said container adjacent to the other end thereof contains a second material in which the first material is to be dispersed or dissolved prior to use characterised in that (a) said intermediate compartment contains a bead but neither said first material nor said second material, and (b) said temporary seals are arranged so that they can be broken by finger pressure to permit communication between the compartments, thereby permitting mixing of said first material and said second material.
The invention will be described hereinafter with reference to its use in clinical applications, although it is to be understood that a device in accordance with this invention may be used for storing and dispensing materials other than pharmaceuticals.
An essential feature of the present invention is the provision of an intermediate area between the two outer compartments which contain the components which are to be mixed prior to their use. The intermediate area greatly assists the user in assessing whether or not the temporary seal or seals has or have maintained its or their integrity, for example, by having a pressure and/or moisture sensitive indicator in this area. Also, if the intermediate area is gas-filled (e.g. with an inert gas such as Nitrogen or with air), the two outer compartments may be air-tight while still allowing ready mixing of their contents. In one embodiment, the intermediate area comprises a single broad temporary seal containing a pressure and/or moisture sensitive indicator.
In another embodiment, the intermediate area of the dispensing device comprises a compartment defined by two temporary seals and may contain a small bead, for example a ceramic bead, which aids in mixing the components in the outer compartments after the two temporary seals have been ruptured. Such a ceramic bead may have on its surface or be impregnated with an indicator sensitive to the liquid contained in the device, so that any seepage of liquid across the temporary seal is evident from (for example) the colour of the ceramic bead. The bead may be any convenient shape, for example conical, spherical, cylindrical, pyramidal or bipyramidal. A shape with a pronounced vertex is useful aiding moisture detection. A further benefit of using such a bead is that it produces a rattling sound when the device is shaken: if seepage of liquid into the intermediate area has occurred, the quality of sound changes. This provides an alternative means of indicating whether the seals have maintained their integrity. The bead may be constructed of a buoyant material so that it floats on the surface of the solution and hence will not interfere with the withdrawal of the solution from the device by a needle and/or syringe.
Advantageously, the ends of the device are sealed by a permanent heat seal. In one embodiment, the seal at one end of the device defines a V-shaped end to the adjacent compartment. After mixing of the ingredients in the device, the V-shape assists in permitting extraction of all of the solution or dispersion from the container.
A dispensing device in accordance with this invention may include a predetermined locus for insertion of a syringe needle. In one embodiment, the device carries on its exterior a small pad which defines the intended puncture site and which assists in providing a seal around the lumen of a syringe needle during use. Alternatively, the device may include at one end thereof an entry channel for a needle or for a syringe, e.g. formed as an injection moulded, rigid plastics or rubber funnel, and may include a seal at the neck of the funnel which is penetrated, in use, by the lumen of a needle.
The entry channel may comprise a funnel which includes a valve at the neck of the funnel, which valve is penetrated in use by the lumen of a needle or by the lumen of a syringe. With such funnel-like needle entry elements, access to the entry point may be protected by a temporary heat seal between flaps of plastics material at the end of the dispensing device which may have a pressure and/or moisture sensitive indicator between the flaps of plastics material. In addition, the entry channel may have a substantially flattened area to assist holding of the device during use. Prior to use, the temporary heat seal will be broken to permit entry of a syringe or needle into the device.
In order to assist the breaking of the or each temporary seal which defines the intermediate area of the device, the exterior of the device may be surrounded, in the vicinity of the intermediate compartment, by a sheath of plastics material, preferably a soft, clear plastics band This has two benefits: firstly, it tends to reduce the risk of the or each temporary seal being accidentally broken during handling of the device prior to its use; and secondly, it facilitates the breaking of the or each temporary seal without discomfort to the user.
Where the powdered pharmaceutical in one compartment of the device is sensitive to light or oxygen, that compartment of the device may be surrounded by, for example, a foil laminate.
Where a syringe is intended to be inserted into a device of this invention through a side wall thereof, there is a possibility that the needle will penetrate the opposite wall of the device, thus wasting the contents of the dispensing device and possibly causing needlestick injuries to the user. To prevent such adverse effects, the device may include a protective liner, either internally or externally, in the region where syringe insertion is intended to occur.
If desired, a peel-off protective strip may be affixed over a rubber pad which is positioned at the needle insertion point.
The or each temporary seal which defines the intermediate area may be linear, and may be disposed orthogonally with respect to the longitudinal axis of the device. Alternatively, the or each temporary seal may be arcuate in configuration. Where the device is intended to contain a relatively large volume of liquid, e.g. 10 or 20 ml, the or each temporary seal may be disposed obliquely with respect to the longitudinal axis of the device so that, for example, the powdered material is contained in a compartment which is triangular when viewed in the plane containing the temporary seal or seals and the longitudinal axis of the device.
Conveniently, devices in accordance with this invention will provide a unit dosage of the pharmaceutical material which they contain. Typically, the device will contain 250 mg or 500 mg of powdered pharmaceutical material and up to 20 ml liquid. The liquid may be, for example, distilled water, normal saline solution, or glucose solution. Other liquids or solutions may be used when desired.
In preferred embodiments of the invention, the two materials in the outer compartments of the device remain in their separate, air-tight compartments until the temporary seal or seals defining the intermediate area is or are broken by applying finger pressure to the sides of the or each seal. Thereafter, the two materials can be mixed together by shaking the container, after which the mixed solution or dispersion is ready for use. Where the pharmaceutical is to be injected by intravenous or intramuscular injection, agitation of the two components should continue until all of the powdered material is fully dissolved.
In any of the above-mentioned embodiments, the plastics container may be formed from two annularly co-extruded polymers, the inner of said two polymers being relatively less resilient than the outer. The outer polymer may be a different colour to the inner polymer, and may have predetermined portions removed to generate indicia.
After use, a device of this invention can be thrown away into an ordinary dustbin; there is no requirement for a "sharps" bin of the type used for disposable syringes.
The container may be made from a plastics material, e.g. polypropylene, by extrusion. The or each temporary seal can be formed by application of just sufficient heat to cause opposite sides of the tube to stick together without forming a permanent bond. The sealed ends of the device may be formed by application of heat and pressure over a longer period of time, thereby generating a permanent heat seal.
According to another aspect of the present invention, there is provided a method for the production of a device of the present invention which comprises forming said container by extrusion; sealing one end thereof; depositing said first or second material into said container and sealing it therein by means of a temporary seal, depositing said bead into said container and sealing it therein by means of another temporary seal, thereby forming an intermediate compartment; depositing said first or second material into said container and sealing it therein by means of a further seal,
wherein said temporary seals are formed by the application of heat to opposite sides of said container so as to cause the sides of the container to stick together without forming a permanent bond and are arranged so that they can be broken by finger pressure.
The seals at the ends of the device may be formed by the application of heat and pressure to opposite sides of the container to generate a permanent heat seal.
According to a further aspect of the present invention, there is provided a method of packaging a pharmaceutical material, which comprises forming a generally cylindrical plastics container by extrusion; sealing one end thereof; depositing a first material into said container adjacent to said sealed end and enclosing it in a first compartment therein by means of a temporary seal; depositing a bead into said container and sealing it therein by means of another temporary seal, thereby forming an intermediate compartment;
depositing a second material into said container and enclosing it therein in a third compartment by means of a further seal,
wherein said first material is a pharmaceutical material and said second material is a diluant, or said first material is a diluant and said second material is a pharmaceutical material, and said temporary seals are formed by the application of heat to opposite sides of said container so as to cause the sides of the container to stick together without forming a permanent bond.
A pharmaceutical material packaged in accordance with the above method may be dispensed by breaking each temporary seal defining said intermediate compartment by applying finger pressure to the edges of the seals, shaking the container, and extracting the resulting solution, dispersion or suspension.
For a better understanding of the invention, and to show how the same may be carried into effect, reference will now be made, by way of example, to the accompanying drawings, in which:
FIG. 1 illustrates a first embodiment of the invention;
FIGS. 2 and 3 illustrate a second embodiment of the invention;
FIGS. 4 and 5 illustrate a third embodiment of the invention;
FIG. 6 illustrates a variant of the embodiment shown in FIG. 4;
FIGS. 7 and 8 illustrate fourth and fifth embodiments, respectively;
FIG. 9 illustrates a sixth embodiment of the invention;
FIGS. 10-15 illustrate alternative constructions of the device at the locus of inserting the lumen of a syringe;
FIG. 16 illustrates a seventh embodiment of the invention;
FIGS. 17, 18 and 19 illustrate three forms of an eighth embodiment of the invention; and
FIG. 20 illustrates a plastics container formed from two annularly co-extruded polymers.
Referring now to the drawings, the dispensing device in all of the figures is formed from a clear, plastics tube, e.g. a polypropylene. The tube is clamped and heated at its ends in order to form permanent seals 2 and 3. The tube, indicated by reference 1 in the drawings, is provided with a temporary seal 4, which defines an intermediate area 5. A first outer compartment 6 is defined between end 2 and temporary seal 4, and a second outer compartment 7 is defined between temporary seal 4 and end 3 of the device. In the embodiment illustrated in FIG. 1, the intermediate area contains a pressure and/or moisture sensitive indicator strip 8, and compartment 7 contains a liquid, e.g. water, normal saline or glucose. In the embodiment illustrated in FIGS. 2 and 3, the intermediate area 5 is defined by temporary seals 4 and 4a, thereby forming a compartment, and sealed end 3 is shaped so that the compartment 7 terminates in a "V" shape 9. A circular disc 10 of silicone rubber is affixed to the outside of tube 1 adjacent to the vertex of "V" part 9, and defines the locus of insertion of a syringe.
A small ceramic bead 11 is present in intermediate area 5. The bead carries an indicator which changes colour in the presence of a liquid from compartment 7, and is constructed of a buoyant material.
The embodiment shown in FIGS. 4 and 5 is generally similar to that of FIGS. 2 and 3, except that the provisions for inserting a syringe needle take an alternative form. In FIG. 4, the "V"-shaped end 9 of compartment 7 terminates, at the vertex of the "V", in a needle entry device 12. This is formed of a relatively rigid plastics material, and comprises a funnel-shaped outer part 13 and a tubular part 14. The tubular part defines a channel 15 through which the needle of a syringe passes to gain entry to compartment 7. Tubular portion 14 extends into compartment 7 and is in communication with the liquid material contained in that compartment via hole 16 in the side of the hard plastics material. A rubber seal 17 is positioned within channel 15 and prevents egress of liquid material from compartment 7. When the device is to be used, temporary seals 4 and 4a are ruptured, and the powdered drug contained in compartment 6 is mixed with the liquid in compartment 7 by shaking the device. Ceramic bead 11 aids in the mixing of the ingredients. When the powder has fully dissolved, a syringe is inserted into the needle entry device 12, and is pushed through the rubber seal 14 into the distal end 18 of tubular portion 14. The syringe action will then withdraw solution from the interior of the device 1 via hole 16, the ceramic bead 11 floating on the surface of solution and hence not interfering with the needle.
Referring next to FIG. 6, a variant of the structure of FIG. 4 is shown. In this variant, entry to the needle entry device 13 is protected by means of a temporary heat seal 19 formed between two flaps of plastics material which constitute an extension of the tubular device 1 beyond the limits of end seal 3. The lowermost portions 20 of these two plastics flaps are left unsealed, so that the two flaps can readily be parted and then pulled to release temporary seal 19 and to permit access to channel 15.
Referring next to FIG. 7, the intermediate area 5 of a device in accordance with this invention is surrounded by a soft, clear plastics sheath 21. This provides some protection for temporary seals 4 and 4a, and also assists the user of the device when the temporary seals are to be broken.
In the embodiment of FIG. 8, a foil laminate 22 encapsulates the compartment 6, in order to protect the material contained in that compartment from environmental factors such as light and oxygen.
Referring next to FIG. 9, a rigid plastics end piece 23 is provided in the interior of the device at the "V"-shaped end 9 of compartment 7. A silicone rubber pad 10 is affixed to the exterior of tube 1 adjacent to a hole 24 in end piece 23. This arrangement permits access of a needle 25 which pierces rubber pad and passes through hole 24 into the interior of compartment 7. End piece 23 prevents the needle piercing end section 9 of compartment 7.
FIGS. 10-15 illustrate alternative arrangements whereby the end of compartment 7 may be protected from unwanted damage when a needle such as 25 is inserted into the device. In FIGS. 10 and 11, a hard, plastics sleeve 25 is fitted over the exterior of tube 1 in the vicinity of compartment 7 and end seal 3. The needle entry point is defined by rubber pad 10 which, as in the case of FIG. 9, is adjacent to an opening 26 in the hard sleeve 25.
FIG. 12 shows a variant which is applicable to any of the embodiments of the invention in which a rubber pad 10 is employed. In this variant, a peel-off protective strip 27 is applied to the exterior face of pad 10.
In FIGS. 13 and 14, a hard plastics clip 28 fits over part of end seal 3 and "V"-shaped end section 9 of compartment 7. A rubber pad 10 is again fixed to the exterior of clip 28 adjacent to an opening 29 in clip 28 to permit needle access. In FIG. 15, a rubber pad 10 is fixed to the outside wall of compartment 7 adjacent to end seal 3, and on the opposed region of compartment 7 there is provided a hard plastics disc 30 heat sealed onto the soft plastics material 1. Disc 30 provides a protective barrier preventing penetration of tube 1 by a needle inserted through pad 10 into compartment 7.
Referring to FIG. 16, the dispensing device has two generally linear end seals 2 and 3', and temporary seals 4' and 4a'. These temporary seals are oblique with respect to the longitudinal axis of the device, and extend from end seal 2 to the wall of tube 1. With the illustrated arrangement, compartment 7 is very much larger than compartment 6. This arrangement is particularly suitable for dispensing relatively large volumes of solution.
In a further embodiment of the invention the device is adapted to enable withdrawal of solution therefrom using a syringe with or without a needle.
Referring to FIG. 17, the tube 1 has a fourth compartment 31 which is defined by a rubber bung 32 at one end and a temporary seal 33 at the other end. The bung 32 defines a first "V"-shape 34 and a second "V"-shape 35. The latter allows the guidance of the syringe towards the valve 36. This valve 36 comprises two flaps 37 and 38, and two corresponding recesses 39 and 40. When the temporary seal 33 is broken by hand, a syringe may be inserted into the valve 36, forcing flaps 37 and 38 apart and into their corresponding recesses 39 and 40, respectively, thus facilitating entry into the compartment 7 and enabling extraction of the solution contained therein.
In FIG. 18 an alternative form of this embodiment is shown. The fourth compartment 31 is defined at one end by a temporary seal 33, as before, and at the other by a constriction 41. This constriction 41 defines a channel through which the lumen of a syringe may be inserted. This channel is sealed by a temporary seal 42 which is broken when the lumen of a syringe is inserted into the channel. The constriction 41 forms a "V"-shape which guides the syringe towards the temporary seal 42. In operation the temporary seal 33 is broken by hand, the syringe is inserted into the compartment 31 and is guided towards the temporary seal 42 by means of the "V"-shape formed by the constriction 41. The temporary seal 42 is broken by the end of the syringe and diluant from compartment 7 may be withdrawn.
FIG. 19 illustrates a further form of this embodiment, wherein the fourth compartment 31 has a permanently sealed area 43 which forms a flattened area which allows the device 1 to be held between the first finger and thumb while the needle and/or syringe is inserted into the entry channel.
In any of the above described embodiments the device may be constructed of annularly co-extruded polymers, the outer of these polymers being relatively more resilient than the inner. The outer polymer is of a different colour to that of the inner polymer, thereby allowing removal of the outer layer to generate indicia, for example, the name of the pharmaceutical and its dosage. This removal can, for example, be achieved by means of a laser.
In all of the above described embodiments the temporary seal 33 may have a pressure and/or moisture sensitive indicator between the two flaps of plastic which are sealed by temporary seal 33 to show accidental opening.
Where a device of this invention is to be used for intravenous or intramuscular drug administration, the overall procedure followed by clinical personnel may be considerably simpler than with conventional methods of drug administration. Conventional IV/IM drug administration involves the following sequence:
1. Check prescription chart for amount and type of medication.
2. Select and check drug bottle.
3. Check amount and type of fluid to be used as dilutant.
4. Make any necessary calculations, i.e. amount of fluid to be mixed with drug.
5. Pick-up and break ampoule of fluid. (Some ampoules without a break seal have to be filed at the end to open).
6. Insert syringe needle into ampoule.
7. Draw-up fluid.
8. Keep empty ampoule for checking purposes.
9. Pick up drug bottle.
10. Remove metal covering around drug bottle top.
11. Swab drug bottle top.
12. Insert needle of syringe dilutant into bottle top via rubber bung.
13. Add fluid from syringe to drug.
14. Withdraw needle.
15. Shake bottle to mix fluid and drug.
16. Re-insert needle into drug bottle.
17. Draw up mixture.
18. Withdraw needle.
19. Pick-up glass fluid ampoule and re-check fluid type, dosage, and expiry date.
20. Pick-up drug bottle and re-check drug type dosage and expiry date.
21. Administer drug to patient.
22. Dispose of both empty containers in special (expensive) "sharps" bin.
In contrast to this, the sequence required for use of a dispensing device in accordance with this invention is as follows:
1. Check prescription chart for amount and type of medication.
2. Select and check dispenser of the invention.
3. Break temporary seal using thumb and finger.
4. Shake to mix drug with correct measure and type of fluid.
5. Swab puncture point.
6. Insert syringe or syringe needle.
7. Draw-up drug mixture.
8. Withdraw syringe or needle.
9. Re-check dispenser for drug type and dosage.
10. Administer drug to patient.
11. Dispose of spent dispenser in any ward rubbish bag.
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|Dec 27, 2007
|Perell William S
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|Mar 2, 2007
|Sep 4, 2008
|Perell William S
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|Dec 17, 2008
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|Perell Willaim S
|Package for consumer products
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|Package With One or More Access Points For Breaking One or More Seals and Accessing the Contents of the Package
|Dec 23, 2008
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|Package with unique opening device and method for opening package
|Sep 20, 2010
|May 5, 2011
|Mark Steele
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|Feb 12, 2010
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|Poppack, Llc
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|Mar 25, 2010
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|Morimoto-Pharma Co., Ltd.
|Pharmaceutical composition container
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|Jan 19, 2012
|Morimoto-Pharma Co., Ltd.
|Pharmaceutical composition container
|Oct 28, 2010
|May 3, 2012
|Tyco Healthcare Group Lp.
|Applicator Tips Having Mixing Ball
|Mar 29, 2011
|Jan 17, 2013
|Morimoto-Pharma Co., Ltd.
|Container for orally ingested pharmaceutical composition
|Jun 18, 2012
|Dec 19, 2013
|Michael Drake
|Method and Apparatus for Mixing Drinks
|Feb 20, 2014
|Aug 21, 2014
|James P. Knutzon
|Multi-compartment bag and method of making same
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|Apr 30, 2015
|Rama Taghvai
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|Feb 28, 2012
|Poppack, Llc
|Holding container with breachable perimeter bubble
|Aug 1, 2008
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|Poppack, Llc
|Access structure with bursting detonator for opening a sealed package
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|William Simon Perell
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|Mar 25, 2010
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|Medicinal composition container
|U.S. Classification
|206/220, 366/342, 604/416, 53/452, 604/903, 222/94, 206/459.5, 383/38, 53/469, 53/474
|International Classification
|Cooperative Classification
|European Classification
|Nov 24, 1993
Owner name: HEATHCOTE-LUNDE LIMITED, GREAT BRITAIN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ALLEN, NICHOLAS JOHN;REEL/FRAME:006773/0250
Effective date: 19931104
|Nov 1, 1996
|Fee payment
Year of fee payment: 4
|Nov 28, 2000
|Maintenance fee reminder mailed
|May 6, 2001
|Lapse for failure to pay maintenance fees
|Jul 10, 2001
|Expired due to failure to pay maintenance fee
Effective date: 20010504


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|Josef Latt <Josef.L...@gmx.net>
|Re: Error when trying to download OO package
|Tue, 20 Mar 2012 14:11:44 GMT
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