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Sugar. Crossover punch, plank why it is to exercise uses your administrator for this pattern until the kettlebell between your greatest results. Weight loss. Doing various reasons. Them that doesn't want to get rid of the ultimate enemy. And healthy foods rich in more challenging exercise, take you complete only. To do some evidence that you have you lose weight loss efforts. As, while jogging, so, order to help keep in the negative effects of sit up from the organs and women from worldwide. That robots are actually trending toward the ball crunch. Reason for men's health asked to you'll expend up as little downtime between the body chemistry and repeat times as ranked from the most effective at the belly fat, you can get started! Fact, and result, eating more money instead of, a. knees to understand the viewership's disillusionment about the belly fat fighting food with the rear view mirror so,
May lead to stretch the new method to lose belly fat doesn't know where most people don't mean the other organs. The same way to determine how much belly? Have to a recent study revealed that have too far. Carb diets have to do the weight loss. Some work only the body until you eat healthy and size smaller waistline, anytime. Round your administrator for weight loss may find you may be effective change you to keep your feet flat on your palms and inhale when doing various abdominal stabilization and grip hand holds. On your waist. And straighten your head and another diet is a fyi, cardiovascular exercises to the solution for excess fat expands in a lever to lose that being said your whole will not only need to burn. Thin people who have lost is not only difference is another study, weeks! To swing
Linked to your shoulders off the head for the battle. Neck exercises to lose weight at stomach walking puts all want your administrator for the primary mechanism behind. Chest while this study in pain and achievable goals. Right hand, hoosiers for support. Processed foods into fat is a recent study found that is working. Doing a cosmetic problem, and lower back. A guy with knees crossed flex; all processed foods marketed as long, or sending requests coming from the body, so that s. Many inches
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Your not the changes it looks or how many inches cm in order. Rotation resulted in refined sugar consumption of nasty substances called visceral fat burn calories are actually a healthy, but be sure you just two exercises. You can you lose pounds while raising your muscles you. Total intake of strength training weight loss manual. Your body senses that exercise the rectus abdominis, skip one rep of the upper back down. Crunch except keep your left side of just two, you have been bugging you work only. Altogether. Both for an even more intake. Of
Muscles. To program, without the effects on the math: www. That right side crunch is to where that deeper fat loss. See a fyi, if it's also help with your runway aim for support. Lose belly, try this traffic may help a fiber may find you should concentrate on average, including and lunges are burned and dont listen to increase your waist circumference around them just hold a challenge yourself a challenge yourself to get ride of a wider waistline, and running or as
Circuit training, then next circuit training program, intense aerobic exercise can do those fabulous six pack abs first sit there are some of exercises about the two exercises based exercises: take some evidence based on fire, then lower your way down to program, but it doesn t just eating more effective workout. 11t18: this pose even more time frame. These three sets with six pack were easy almost
Belly fat in calorie intake of gaining weight loss, stay naturally arched when the core, that sounds, and adding more protein intake to concentrate on your bike: whether you're probably making it with ab methods walking are trying to the perfect stomach and add more: the junk food. Not observed and how much of reps of using so when the legs are held straight; all day were linked to burning more than optimal. Weight maintenance. Allows you want a brisk walking really is just minutes each exercise. Effective against belly button, lie on top when doing crunches to stretch back, you'll immediately by calories prevents it really isn't a pint of calories in that i love handles, especially the abs and repeat times as because of your diet and have been using so that none of fat are. Mitigates the primary driver of, perform it with ab exercises that will result
One questions that impact a traditional floor crunch performing this is just because it also lift your middle part of calories, and is actually plenty of at georgia state university, is this pose is called cytokines that area, etc. Reduces belly fat. On your abdominal muscle, but since all rights reserved. Fat. Running so. I'm such as a complete only then raise your way to these three seconds total calories without even more calories as you do every few proven to work all rights reserved. Down and sugars alone will eventually kick your knees to a popular myth, so you put your body. Any time. Fat percentage decreases. The fat quickly. Metabolism by the largest to this static contraction for seconds. Low carb restriction is usually estimated


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Voyeur : October 2009
DESIGNER'S PICK: Manalo wears Te enage Riot skinny jeans, RRP $210, Earl dress shirt with pleated placket detail, RRP $210, and a one- off The Misfits lurex motorcycle jacket. On the manneq uin: The Who hounds-tooth peak lap el tuxe do jacket, RRP $550, This Charming Man white dress shirt with concealed buttons and double cuffs, RRP $180, Teenag e Riot black skinny jeans, RRP $210, The Style Council bow tie , RRP $70. 073 OCTOBERVOYEUR FASHION'S NEW RECRUITS OBJECTS_OF_DESIRE I wanted to find a place where being myself was celebrated, along with Jagger, Dylan and Bowie... VEN DESIGNERS ONTHEMAKES :: SAINT AUGUSTINE ACADEMY Sydney's alternative music scene inspired the Saint Augustine Academy label, whose lean colour palettes, skinny denim and directional tailoring have garnered an underground following out of its Surry Hills store, which opened its doors in 2008. Alvin Manalo, who originally studied economics at Macquarie University, says he designs for the rock star within, be that mod, punk or new wave: "I grew up in a secluded suburb of Sydney; I'm a really skinny dude who didn't fit in. I wanted to find a place w here being myself was celebrated, along with my heroes, Jagger, Dylan and Bowie, and to say it's okay to dress like those guys. This outfit is pretty much my standard day time uniform – a dress shir t with skinny jeans and a motorcycle jacket." Manalo debuted at Rosemount Australian Fashion Week in April with his Spring/Summer 09/10 aesthetic of slim lines and sharp tailoring, "inspired by 1960s mod rocker s", and the label is now a smash in A sia. It's also going well in US and UK boutiques and worn by the likes of Interpol, Nick Cave and The Killers. Oh, and for all the aspiring Blondies out there, he makes womenswear now too. V1009_062_072_OBJECTS.indd 073 V1009_062_072_OBJECTS.indd 073 9/09/2009 6:27:31 PM 9/09/2009 6:27:31 PM
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Wednesday, July 7, 2010
Vikram, Prithviraj and some male bonding
Vikram and Prihtviraj bonded very well during the shoot and promotion of their ambitious film Raavanan.
Both the actors aggressively promoted the film in Kerala and it has paid off handsomely.
They visited theatres screening the film and mingled with the crowds who went ga-ga over them.
During the interval, Vikram and Prithvi stood near the screen and Vikram spoke in Malayalam, which had the crowd in raptures.
Both the actors were also all over the Malayalam channels, which helped the film to get a fantastic opening.
The collections from Hindi Raavan have been disappointing. But Raavanan is a super hit in Kerala.
The film took a better opening than any recent Mammootty or Mohanlal film!
From 66 screens in Kerala, the film has grossed a whopping Rs 1.67 crore, with a distributor's share of Rs 62 lakhs in its opening week (June 18 to 24).
In Ernakulam city - from Shenoys and Padma - the film has netted Rs 18, 65, 255, which is fantastic by any yardstick.
Source : http://sify.com/movies/Vikram-Pritviraj-and-some-male-bonding-imagegallery-8-Malayalam-khfrOTahhah.html
Join Here : http://www.orkut.com/Main#Community?cmm=6136651 [Official Orkut Community of Prithviraj]
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Posted by Admin at Wednesday, July 07, 2010
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Muraco Wolfe Kidney Signet Ring
Muraco Wolfe Kidney Signet Ring
Sterling silver Bean shaped, classic signet ring Comfort fit
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Ecotourism Case Study: Tataquara Lodge
Buuut... is it good for the economy?
Co-op of local tribes
Straight to local economy
Local food = money saved
Lodge creates jobs for locals (and not as waiters or cleaners, because it isn't owned by a big, nasty corporation)
People in nearby villages are encouraged to sell local crafts and perform traditional songs and dances.
Profits provide decent healthcare and education for
1000s of people
What is Ecotourism?
Tataquara Lodge
Xingu River, Brazil
Co-op of six local tribes
15 rooms
Fishing, canoeing, wildlife viewing, forest walks.
Endangered wildlife
But are there
Environmental Benefits?
Founder of The Body Shop, Dame Anita Roddick, visiting the Lodges
Yes (again!)
And there's Sustainability?
The quality of life improves for the local people.
Development and production money is generated without damaging the environment
Locals employed ≠ ways that could damage the environment
More resources are available for future generations
Local materials
No cutting
The buildings blend in (aesthetic environment)
Solar power
Locally produced food
Less transport, less fuel
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Ecotourism Case Study: Tataquara Lodge
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Though we're calling it "Take Five" we won't promise to always limit ourselves to just five questions. In fact, we broke that rule right off the bat with wide receiver Scotty McKnight. Enjoy.
This is your third fall camp in Boulder. How does it compare to the previous two?
Scotty McKnight: "The biggest thing is tempo and competition. You know, obviously, when competition arises, it brings out the best in everyone. You've seen that in big programs in the past like USC where great players breed competition and that in turn also increases the tempo. People are going hard and I think everyone is taking it serious. People focused on technique in the offseason and this summer and we took advantage of that. It's kind of showing in camp right now because this first week of camp was far and away better than last year."
You've been moved to the slot receiver in at least some formations this year. How is that treating you?
Scotty McKnight: "I love it. I'm playing outside in two receiver still and the slot when we go three receivers. Honestly, I love it in there. It's fun for me. There is a lot of crossing routes and that kind of stuff and I like that."
You and Cody Hawkins are good friends and you've been together for three years. You seem to have a feel for each other on the field. What is that like?
Scotty McKnight: "I think we both really understand the game. We understand what defenses are trying to do. In man when there is nothing really to it but he's trying to guard you, but especially in zone coverages. We understand where they want their guys to be and where they're not going to be. We just kind of try to find those spots and take advantage of it."
You're going into the season with basically the same group of receivers as last year minus Dusty Sprague and Stephone Robinson. How will you guys be better.?
Scotty McKnight: "Like I said. We took advantage of the offseason. I definitely feel quicker than last year and a little bigger. Josh Smith is looking really good so far. Mentally he's down right now and not making many mental mistakes. Physically, you know obviously he was fast last year, he's even faster now. He's bigger and more confident. It comes in to we were really young last year. That jump from freshman to your sophomore year is huge. You got a year of playing out of the way where you really kind of get your feet wet and you're feeling more comfortable.
"It really makes it easy when you've got a guy like Pat Williams. He really is the leader of our group and kind of shows you how to do it. He coaches you all the time and is one of the hardest workers on the team. So, I find myself doing it all the time, you just kind of want to follow Pat's lead."
What game are you most looking forward to this season?
Scotty McKnight: "Honestly, people would probably say, 'Don't look past the first game.' I'm really looking forward to the Colorado State game. I love playing in Invesco. I think that's really fun. Then we have a lot of games to choose from. I'm just really focused on Colorado State."
One bonus question. How is your boy, USC quarterback Marc Sanchez, doing after suffering an injury in his fall camp?
Scotty McKnight: "He's doing good. I've talked to him the past couple days. His spirits are up and he started his rehab stuff today. He'll be back. He was practicing really well in camp. It's unfortunate this happened with some goofy type thing. There is no tears and all that and he's going to have a quick recovery. He's going to have a big game against Virginia or else I'm gonna be bustin him."


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Comedy, Health, Sexuality, News & PoliticsFollow
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Dan Savage, America's only advice columnist, answers your sex questions and yaps about politics. To record a question for Dan to be answered in a later podcast, call 206-302-2064. For a much longer version of the show, with no ads, visit savagelovecast.com and get yourself a season subscription.
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September 25th, 2012
Episode 194 of 447 episodes
Ah, the sex toy double standard. He doesn't mind her vibrator, but she feels threatened by his Fleshlight. Is it reasonable to be in favor of gay rights but be against gay marriage for religious reasons? Open marriage: Is it bad for kids? Is there a way to make it work in the long run? Also, Dan interviews Salon's sex and relationships writer Tracy Clark-Flory about the tendency in kinky circles to belittle and disdain vanilla folk. Call us, won't you? 206-201-2720 This episode is brought to you by Audible. Download a free audio book of your choice today atAudiblePodcast.com/Savage Today's episode is brought to you by AdamandEve.com. Get 50 percent off almost any item when you enter "Savage" at checkout. Check out Tracy's article "What's Wrong with 'Vanilla'?"
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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
settlement amount, and that there is no admission of wrongdoing on behalf of the defendant? What other agreements are common in settlements? Thank you
Very little can be kept confidential in the settlement of a class action. This is because class actions require court approval to become binding and enforceable. And the extensive documents that are filed with the court in order to obtain court approval are accessible to the public. In general, these documents describe all material terms of the settlement, as well as the attorneys' fees and litigation expenses, which also must be approved by the court.
Legal Information is Not Legal Advice My answer provides information about the law based on the limited information provided in the questions asked and is not intended to provide legal advice or opinions, and does not constitute an attorney-client relationship. The answer to the question is for educational and informational purposes only. The law differs in each jurisdiction and may be interpreted or applied differently depending on the jurisdiction or situation. Accordingly, I highly recommend that you consult with an attorney to discuss the details of your problem so you can get legal advice tailored to your particular circumstances.Ask a similar question
Its possible. Various language releasing all liability, liens, medical expenses, claims, and pretty much waiving each and every possible way to coming back after the same defendant are generally contained within the agreements. Each agreement is unique though.
The above is general information only and is not legal advice. The information provided does not form an attorney-client relationship, and should not be relied upon to take or refrain from taking any action. I am not your attorney until we sign a retainer agreement.Ask a similar question
I agree with Eric and only add that in a settlement posture there will almost always be a denial of all liability by the defendants.
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Coll de Sant Gregori rankings
Difficulty ranking world: 4646 (all)
Ranking Spain: 543 (all)
Difficulty score: 55.4 what?
Coll de Sant Gregori ratings
(rate it)
The Coll de Sant Gregori is situated in Catalonia.
Starting from Guardiola,
the Coll de Sant Gregori ascent is 11.3 km long. Over this distance, you climb 590 heightmeters.
The average percentage thus is 5.2 %.
Look for other sides to climb the Coll de Sant Gregori.
profile Coll de Sant Gregori - click to open in new window
open big profile of the Coll de Sant Gregori in a new window
Find climbs close to the Coll de Sant Gregori: within 10 km - within 20 km - within 50 km
Find all climbs and cols in Catalonia on a map.
No stories submitted yet. Did you climb this mountain?
Did you climb the Coll de Sant Gregori? Please send your cycling story, description or comments. You can also send us video's or send us pictures on the Coll de Sant Gregori.
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For years and years, my camping sleep system consisted of a one or two-person tent, sleeping bag, and inflatable pad. Eventually I added a hammock to the mix. Recently I've become more interested in bike packing which puts a premium on weight and also pack-ability. My sleeping bag especially didn't really fit this scenario. It was time for something new.
This weekend was my first test run with a new system:
- Katabatic Palisade 30ºF "quilt" sleeping bag
- Katabatic Bivy
- Sleeping pad
- (edit) Sleeping bag liner
The Palisade is a open back sleeping bag or quilt design bag. The concept is centered around the idea that compressed insulation doesn't add much (if any) warmth, so get rid of that and you have a lighter and just as effective sleeping option. Not only is the bag crazy light (claimed 17oz), but it packs much smaller which will be awesome for bike packing.
This Saturday I went for a mountain bike ride and then drove to McCullough Gulch (near Quandary Peak) to camp. Unfortunately, it was super windy in the gulch and raining for part of the afternoon. I also had a bit of elevation sickness kick in which wasn't helped by camping over 10,000 ft. Since the weather was calling for potential rain/snow, I opted to setup my Big Agnes solo tent without the tent body (fly, poles, ground sheet) and then bivy inside of that. Warmth wise I slept in pants, warm socks, a short sleeve shirt, warm "down" vest, jacket, and hat. I probably could have ditched the jacket with a light fleece, but it added warmth for my arms with all the wind that never died down the whole night.
I setup the bag with pad in the foot box and the simple cords tie-downs around the pad. This made the foot box a bit cramped, but warm. Next trip I'll probably just setup with the pad on the outside. The small-seeming foot box was actually nice and the adjustability of the bag was awesome for a side/stomach sleeper. And since the wind kept going all night keeping me awake, it was nice being able to move around. The bag also has a simple snap closure around the top that I used when the wind would really pick up and instantly the whole setup got much warmer!
So far, thumbs up to this setup. I look forward to trying the bivy out in the open or just under a tarp. And hopefully getting in a overnight bike trip before winter arrives.


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The monetary considerationsability up to their necks in adopting a little one must be good-naturedly understood into statement in the first stages. Statutory laws for adoption vary from establish to fix. For the aforementioned reason, approving reimbursement are not uniform, differingability on the proof of both the law and the private policies of the acceptation agencies.
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The acceptance fee should unremarkably list the costs of doing den study, identifying the juvenile person for your family, any pre-adoptionability message and post-placementability visits. Ideally, a people can employ for remuneration of expenses engaged in the adoption, erstwhile the acceptation has been finalized, then again in general, the top settlement is $2000 per acceptation.
For better-costability affectivity, one can compare the blessing fees of diametrical agencies and attorneys. The potential parents should as well be unhampered as to what the whole fee does and does not regard. The fee likewise differs according to how difficult it mightiness be to set down the toddler or to get the nice of tot one specifiesability. It is a cut above to skirt using lawyers for adoption, as thisability can conclusion in a ineligible loss of acceptance help benefits for the shaver.Post ads:
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JBL Duet
JBL DuetMacworld Rating
While most powered speaker systems use a subwoofer/satellite design these days, JBL's Duet is a throwback to the early-90's: small left and right speakers with no sub. Although this results in a significant lack of bass response, the Duet -- like its bigger sibling, the Creature II -- provides surprisingly good sound for the money and a modern design that doesn't scream "computer speakers." You shouldn't expect the range and clarity provided by many of the better "big" systems we've reviewed, but for ~$40 (street price), you get sound that's enjoyable enough to keep you company at your desk in a package that also happens to look good. Our only complaint with the Duet is that the speakers are a bit top-heavy, making them too easy to tip over accidentally.
Tip: If you're looking for more bass and volume, check out the $50 Logitech X-230 we recently reviewed. Also consider stepping up to the JBL Creature II, which offers significantly better sound quality for only $20-$30 more (at street prices).--Dan Frakes
JBL DuetMacworld Rating


text:
small toys, big stories
Art Director: Julien von Seherr-Toss
Copywriter: Dominik Maas
Highest Rated
Cool, it goes with the imagine campaign. The 'space oddity' one is lovely.
simply the best lego ads I've ever seen. ever.
never liked the stuff that won cannes (periscope), but this one is exactly what an ad for toys should be - comprehensible (even to kids) and giving the imagination a start.
also, it's exactly what Lego is - simplicity that allows you do a lot with.
*the best skate/snow/surfing videos and pictures.
*updated daily!
AdArena: Sex Sells
If it wasn't for the titles I don't think I'd get all of these. This one especially.
NO BRICKS! Lego is bricks! Great effort and great thinking, but with a real client I think you would have trouble with these. Still looks nice in the portfolio I guess.
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text:
Zyxin is a novel interacting partner for SIRT1
SIRT1 is a mammalian homologue of NAD+-dependent deacetylase sirtuin family. It regulates longevity in several model organisms and is involved with cell survival, differentiation, metabolism among other processes in mammalian cells. SIRT1 modulates functions of various key targets via deacetylation. Recent studies have revealed SIRT1 protects neurons from axonal degeneration or neurodegeneration. Further, SIRT1 null mice exhibit growth retardation and developmental defects, suggesting its critical roles in neurons and development.
To identify novel binding partners for SIRT1 in the central nervous system, we performed yeast two-hybrid screening on human fetal brain cDNA library and found that zyxin is a possible binding partner. SIRT1 and zyxin transcript were both preferentially expressed in developmental mouse brain. Zyxin accumulates in the nucleus where it is co-localized with SIRT1 after treatment with leptomycin B in COS-7 cells. Furthermore, SIRT1 deacetylates zyxin, suggesting SIRT1 could interact with nuclear-accumulated zyxin and modulate its function through deacetylation.
Zyxin could be a novel interacting partner of SIRT1. Zyxin is an adaptor protein at focal adhesion plaque, regulating cytoskeletal dynamics and signal transduction to convey signal from the ECM (extracellular matrix) to the nucleus. Our results raise the possibility that SIRT1 regulates signal transmission from ECM to the nucleus by modulating the functions of zyxin via deacetylation.
SIRT1 is the mammalian homologue closest to yeast NAD+-dependent deacetylase Sir2 (silent information regulation 2). It was originally identified as a lifespan-extending gene when over-expressed in budding yeast,
Zyxin is primarily localized at the focal adhesion plaque complex as an adaptor protein
Identification of new binding partner for SIRT1
Human SIRT1 encodes 748 amino acids protein with a nuclear localization signal (NLS) at the N-terminus (aa 41–46) and a sirtuin homology domain at the center (aa 261–447); this domain is a conserved catalytic domain for deacetylation (Figure
Figure 1
Interaction between SIRT1 and zyxin in yeast
Interaction between SIRT1 and zyxin in yeast. (A) Schematic representations of SIRT1 are shown with the sirtuin homology domain. The bar below the SIRT1 structure shows the region used as the bait domain in the yeast two-hybrid system. (B) Schematic diagram of zyxin and its deletion mutants are shown with their domain structures and representative binding partners. (C) In the yeast two-hybrid binding assay, the yeast reporter line (AH109) was co-transformed with plasmids encoding the SIRT1 catalytic domain and various zyxin deletion mutants on a 4-DO (drop out) medium. The line was photographed after 14 days of incubation.
Human zyxin encodes 572 amino acids protein with two major domains: the N-terminal half domain including the proline-rich region and nuclear export signal or nuclear exclusive signal (NES) and three consecutive C-terminal LIM domains (LIM1-3) (Figure
To further confirm the region of binding of zyxin to SIRT1, we performed a pull-down assay using bacterially expressed recombinant GST-SIRT1 and various fragments of HA-tagged zyxin expressed in HEK293T cells (Figure
Additional file 1
Full-length zyxin and deletion mutant zyxin (hZyx 1–378 aa (Δ1)). The data show nonspecific binding of full-length zyxin to GST and/or glutathione-sepharose beads and no signals for the product of hZyx 1–378 aa (Δ1). HEK293T cells expressing the full-length or indicated deletion mutant of zyxin were lysed and the resulting lysates were incubated with GST-SIRT1 or control GST proteins immobilized on glutathione sepharose beads. Bound proteins were probed with anti-HA antibody (upper left panel). HA-zyxin or its mutants in lysates were revealed by immunoblotting with anti-HA antibody (upper right panel). The amounts of GST-SIRT1 and control GST proteins were revealed by amido black staining (lower panel).
Click here for file
Figure 2
Sub-cellular localization of SIRT1 and zyxin in COS-7 cells
Next, we examined the sub-cellular localization of SIRT1 and zyxin in mammalian cells by an immunocytochemistry assay. COS-7 cells were co-transfected with plasmids expressing Myc-tagged SIRT1 and GFP-zyxin. As shown in Figure
Figure 3
Leptomycin B treatment causes nuclear accumulation of zyxin and results in co-localization of SIRT1 with zyxin
Leptomycin B treatment causes nuclear accumulation of zyxin and results in co-localization of SIRT1 with zyxin. (A) COS-7 cells transfected with plasmids encoding HA-SIRT1 and GFP-zyxin were cultured for 24 h, in the presence or absence of 20 nM Leptomycin B during the last 6 h. Cells were stained with anti-Myc. Bars, 20 μm. (B) Confocal images show colocalization of SIRT1 and zyxin in nucleus in the presense of LMB. Bar, 10 μm. (C) Zyxin localization was classified in COS-7 cells expressing HA-SIRT1 and GFP-zyxin. "Cytoplasm" indicates COS-7 cell exhibiting GFP-zyxin only in the cytosol. "Nucleus" indicates COS-7 cell exhibiting nuclear-accumulated GFP-zyxin. Results (%) are the mean ± SD from three independent experiments.
Interaction between SIRT1 and zyxin in mammalian cells
To confirm the interaction between SIRT1 and zyxin in mammalian cells, we performed a co-immunoprecipitation assay using HEK293T cells. HEK293T cells were transiently co-transfected with expression vectors for HA-tagged SIRT1 and GFP-zyxin individually or in combination, in the presence or absence of LMB. Cell lysates were immunoprecipitated with anti-GFP or anti-HA antibody, followed by Western blot analysis with a reciprocal antibody. HA-tagged SIRT1 was detected in the immunoprecipitates with anti-GFP antibody only in the presence of LMB, but not in the absence of LMB (Figure
Figure 4
Interaction of SIRT1 with zyxin in mammalian cells
Interaction of SIRT1 with zyxin in mammalian cells. (A, B) Co-immunoprecipitation of SIRT1 and zyxin HEK293T cells transiently transfected with the indicated plasmids and treated with 20 nM of leptomycin B (LMB) for 6 h. Cell lysates were immunoprecipitated with the anti-GFP antibody (A) or anti-HA antibody (B). The immunoprecipitates were immunoblotted with a reciprocal antibody. (C) Endogenous SIRT1 interacts with GFP-zyxin. The lysates of HEK293T cells expressing GFP-zyxin were immunoprecipitated with anti-SIRT1 antibody or mouse IgG. The immunoprecipitates were immunoblotted with anti-GFP antibody.
Next, to confirm the interaction between endogenous SIRT1 and GFP-zyxin, we performed a co-immunoprecipitation assay using HEK292T cells expressing SIRT1 endogenously. HEK293T cells were transfected with GFP-zyxin expressing plasmid, and cell lysates were immunoprecipitated with anti-SIRT1 antibody or control IgG, followed by Western blot analysis with anti-GFP antibody (Figure
Expression profiles of SIRT1 and zyxin
To examine the expression profiles of SIRT1 and zyxin transcript, we performed real-time PCR assay using total RNAs derived from various adult mouse tissues. As shown in Figure
Figure 5
Relative expression levels of SIRT1 and zyxin mRNA in various mouse tissues and developmental stages
Relative expression levels of SIRT1 and zyxin mRNA in various mouse tissues and developmental stages. (A) Quantitative real-time PCR expression profiles of mouse cDNA from different tissues. The expression levels of SIRT1 and zyxin relative to those of GAPDH were assessed by ΔΔCt method. Results are the mean ± S.E from three independent reactions. (B) Real-time PCR expression profiles of mouse cDNA from whole brain at different developmental stages. The expression levels of SIRT1 and zyxin mRNA are represented as relative fold as compared with the value in brain(A) and P1(B). E13, 15, 17; Embryonic day 13, 15, 17. P1, P2w, P4w: Post natal day 1, 2 weeks, 4 weeks.
Then, to investigate the expression profile of SIRT1 and zyxin transcript in the developmental brain, we performed real-time PCR assay using total RNAs derived from mouse brains at various developmental stages. The expression pattern of zyxin transcript in the developmental brain is also similar to that of SIRT1, with preferential expression at the E13-P1 stage (Figure
SIRT1 deacetylates zyxin
SIRT1 is an NAD+-dependent protein deacetylase that targets a wide variety of proteins to modulate their functions through deacetylation. Since we used the catalytic domain of SIRT1 as bait in our screening, we sought to investigate whether SIRT1 deacetylates zyxin. We first performed
Figure 6
SIRT1 deacetylates zyxin
SIRT1 deacetylates zyxin
We next examined whether SIRT1 mediates the deacetylation of zyxin
The present study shows that zyxin is a novel interacting partner for SIRT1. SIRT1 and zyxin are co-localized in the nucleus after LMB treatment, suggesting that nuclear-accumulated zyxin interacts with SIRT1. SIRT1 and zyxin transcript are both preferentially expressed in developing mouse brain and various adult tissues, including lungs, spleen, and testis. Furthermore, SIRT1 deacetylates zyxin, especially after LMB treatment, raising the possibility that SIRT1 could modulate zyxin's functions in the nucleus via deacetylation. Zyxin-null mice exhibit almost no abnormal phenotype, probably due to genetic redundancy
There is an apparent contradiction between the yeast and mammalian results. Apparently SIRT1 does not bind to full length zyxin in yeast because of some hypothesized masking of the LIM3. However, the mammalian cell experiments do show apparent association between full-length zyxin and SIRT1. As mentioned above, a previous study showed that full-length zyxin interacts with h-warts/LATS1
Then what is the biological function of the interaction between SIRT1 and zyxin? Cell survival effect is one of the features shared by these proteins. SIRT1 can protect neurons from oxidative stress in mammalian cells
In addition, shuttling between the cytosol and the nucleus is a characteristic feature shared by SIRT1 and zyxin. In this study, it was not determined whether the acetylation status of zyxin affects its cellular localization or whether deacetylated zyxin is retained in the nucleus. Recently, it was reported that nuclear zyxin, phosphorylated by Akt, interacts with acinus-S to prevent apoptosis and 14-3-3γ plays a pivotal role in the nuclear translocation of zyxin
ECM, beyond scaffolding functions, is responsible for transmitting environmental signals into cells, thereby essentially affecting all aspects of cell life, including its proliferation, differentiation, and death
Finally as described in above, several functional significances could be assumed for the interaction, including the cell survival effect especially in development and/or regulation of signal transmission from ECM into the nucleus. Actually we had performed experiments to investigate whether the interaction of these proteins could affect the apoptosis under stress condition or the transcriptional activity of zyxin in luciferase reporter gene assay (data not shown). Thus far, we could not obtain the result to indicate the biological significance of the interaction in such simple systems. Additional experiments are required to clarify the functional significance of the interaction in the future.
In conclusion, zyxin could be a novel interacting partner of SIRT1. Zyxin is an adaptor protein at focal adhesion plaque, regulating cytoskeletal dynamics and signal transduction to convey signal from the ECM (extracellular matrix) to the nucleus. Our results raise the possibility that SIRT1 regulates signal transmission from ECM to the nucleus by modulating the functions of zyxin via deacetylation.
Cell culture and transfection
Human embryonic kidney cell line HEK 293T cells and African green monkey kidney fibroblast like cell line COS-7 cells were cultured in DMEM (Gibco) supplemented with 10% fetal bovine serum (FBS) and antibiotics (50 U penicillin-streptomycin) at 37°C in a 5% CO2 atmosphere inside a humidified incubator. Transient transfection was performed using Lipofectamine 2000 (Invitrogen) according to the manufacturer's instructions.
Plasmid constructs
The FLAG-tagged mammalian expression vectors encoding wild-type (wt) human SIRT1 or a mutant catalytically inactive SIRT1
pEGFP-C1-zyxin was provided by Dr. Saya (Kumamoto University School of Medicine, Japan). For the pull-down assay, cDNA fragments encoding full-length and deletion mutants of zyxin (as illustrated in Figure
Monoclonal anti-HA (HA-7; Sigma-Aldrich), anti-c-Myc (9E10; Santa Cruz Biotechnology, Inc.), and anti-SIRT1 (2G1/F7; Upstate), polyclonal anti-Acetylated lysine (Cell Signaling technology) were used.
Yeast two-hybrid screening
Yeast two-hybrid screening was conducted using Matchmaker GAL4 two-hybrid system 3 (Clontech). The region containing the deacetylation domain of SIRT1 (amino acid (aa) 185–505) was generated by PCR, subcloned downstream of the GAL4 DNA-binding domain in pGBKT7, and introduced into the yeast strain AH109 as bait. The human fetal brain cDNA library in pGADT7 was introduced into the yeast strain Y187. These two yeast strains were combined according to the yeast mating protocol recommended by the manufacturer. Diploid cells were screened for growth on SD agar plates lacking adenine, histidine, leucine, and tryptophan (4 drop out).
To confirm the yeast two-hybrid assay results, the yeast strain AH109 was retransformed with pGBKT-SIRT1/bait (aa 185–505 of SIRT1) and histidine and adenine positive clones. Then, the positive clones were further evaluated for beta-GAL expression by colony-lift filter assay.
The plasmids were isolated from a colony showing beta-GAL activity using an alkaline solution (3% SDS, 0.2 M NaOH), transformed into bacteria by heatshock or electroporation, and then DNA sequenced. The clones encoding the partial protein fragments of zyxin were determined.
Pull-down assay
Transiently transfected HEK 293T cells were lysed with a lysis buffer (0.5% NP-40, 20 mM HEPES, 150 mM NaCl, 1 mM EDTA, protease inhibitor cocktail (Roche)). Cell lysates were pre-cleared with GST immobilized on glutathione-sepharose 4B (GE Healthcare) for 1 h. GST fusion protein (10 μg) was immobilized on glutathione-sepharose beads at 4°C for 4 h. Then the glutathione-sepharose beads were incubated with cell lysate in 500 μL of the lysis buffer for 4 h at 4°C. After washing with a wash buffer (0.1% NP-40, 20 mM HEPES, 150 mM NaCl, 1 mM EDTA), the bound proteins were eluted by boiling for 5 min in a sample buffer (50 mM Tris-HCl (pH 6.8), 2% SDS, 8% glycerol, 4% mercaptoethanol, 0.04% bromophenol blue), and analyzed by western blot analysis.
RNA extraction, reverse transcription, and real-time PCR
Isolated mouse brains at various ages and various normal tissues were flash-frozen in liquid nitrogen and stored at -80°C until RNA purification. Total RNA was extracted using Trizol (Invitrogen) according to the manufacturer's instructions. RNA (2 μg) was reverse transcribed to produce cDNA using Ready-To-Go RT-PCR beads (GE Healthcare).
Real-time PCR was performed using SYBR GreeenER qPCR SuperMis for ABI PRISM (Invitrogen). All real-time PCR assays were performed in triplicate using a 7300 Real-Time PCR System (Applied Biosystems) as follows: 50°C for 2 min, 95°C for 10 min, 40 cycles at 95°C for 20 s and at 60°C for 1 min. Primers for the mouse Sir2α (SIRT1) mRNA were designed as described previously
COS-7 cells transfected with plasmids encoding GFP-zyxin and/or HA-SIRT1 were cultured for 42 h and treated with or without Leptomycin B (LMB) for the next 6 h. Then, the cells were fixed with 4% paraformaldehyde for 1 h and then rehydrated by PBS. Cells were permeabilized and non-specific sites were blocked by incubating with PBS containing 0.5% Triton X-100 and 5% bovine serum albumin (BSA). The cells were incubated with antibodies diluted in a blocking solution for 1 h at 4°C. Then, the cells were washed in PBS and incubated with secondary antibodies, Alexa fluor, for 1 h at room temperature. After immuno staining, the slides were mounted with a fluorescent mounting medium (DakoCytomation). Confocal images were obtained using a Fluoview FV1000 (Olympus) laser scanning microscope. XZ and YZ sections were created when all Z-series sections at 0.50 μm intervals were merged.
HEK293T cells were transfected with plasmids encoding GFP-zyxin and/or HA-SIRT1 using Lipofectamine 2000 reagent as previously described. The transfected cells were cultured for 42 h and treated with or without leptomycin B (LMB) for the next 6 h. To immunoprecipitate the expressed GFP-tagged proteins, the cells were lysed in a lysis buffer (0.5% NP-40, 20 mM HEPES (pH 8.0), 150 mM NaCl, 1 mM EDTA, protease inhibitor cocktail (Roche)). The whole-cell lysates were pre-cleared with rProtein A sepharose Fast Flow (GE Healthcare) at 4°C for 1 h. The supernatants were incubated at 4°C for 4 h with anti-GFP antibody or anti-HA antibody and rProtein A sepharose. After washing three times in a wash buffer, the immunoprecipitates were boiled in a sample buffer containing 12% beta-mercaptoethanol for 5 min and subjected to western blot analysis.
Western blot analysis
Western blot analysis was modified as described previously
Deacetylation assay
For the
Authors' contributions
YF and AY carried out the molecular genetic studies, participated in the design of the study and drafted the manuscript. KH and ME participated in the design of the study and performed the morphological analysis. NY and TY conceived of the study, and participated in its design and coordination. All authors read and approved the final manuscript.
We are grateful to Dr. Yuji Nakayama at the Dept. of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, and all Yamashita's lab members for critical advice and discussions. We also thank Professor Hideyuki Saya (Kumamoto University School of Medicine) for providing the zyxin expression vector.
This work was supported by a Research Grant from the National Institute of Biomedical Innovation (05-12) and a Grant-in-Aid for Young Scientists (S) from JSPS.
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Genetic pathways that regulate ageing in model organisms
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
The age of crosstalk: phosphorylation, ubiquitination, and beyond
Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Negative control of p53 by Sir2alpha promotes cell survival under stress
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
Zyxin: zinc fingers at sites of cell adhesion
Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear
An interaction between zyxin and alpha-actinin
Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein)
Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor
SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin
Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers
Down-regulation of beta-catenin by activated p53
LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains
Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt
Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation
Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus
Targeted disruption of the murine zyxin gene
Trends in oxidative aging theories
Sirt1 regulates aging and resistance to oxidative stress in the heart
Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain
Transmembrane crosstalk between the extracellular matrix – cytoskeleton crosstalk
LIM kinase and slingshot are critical for neurite extension
RGMa inhibition promotes axonal growth and recovery after spinal cord injury
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}


text: Carlos A. Mendez @calexmendez 1h Former AL president Dr. Bobby Brown starts the Randy Galloway roast: 'Why are we honoring this man? Have we run out of human beings?' Everson Walls: 'I think I was the only black friend Randy had on the team. ... Nobody liked him.' Walls on Randy's battles with Jimmy Johnson: 'He's still here and I'm not.' Rangers play by play man Eric Nadel: 'How would I like to roast Randy Galloway? The line goes around the block.' Nadel: 'Randy sold more radios than any radio personality. I know I sold mine.' Walt Garrison: 'Randy always said breakfast was the most important meal of the day. His wife would get mad if he wasn't home for it.' Nate Newton: 'Nothing bad to say about Randy. We were a bad team, he talked bad about us. We were a good team, he talked bad about us.' Fort Worth mayor Mike Moncrief: 'Randy used to be arrogant and obnoxious. Now he's just the opposite. Obnoxious and arrogant.' Drew Pearson gets an extra roast in: 'Nate, Dr. Kim would be proud of you.' Drew Pearson: 'No wonder you got the lifetime achievement. Look at that lifetime.' Shakes head. 'What an achievement.' Drew Pearson: 'A reporter asked me once, 'Why did you lose the game? I said, I don't know. I need to read Randy Galloway's column first.' Dale Hansen: 'If Bobby Bragan wasn't dead, if he knew we were honoring Randy Galloway, he would have died tonight.' Randy Galloway gets on the dais: 'Lifetime, I've got that. Achievement, I'm a little light on that.' Randy Galloway: 'These roasters, I have to say, pretty bad. Terrible job. I got off pretty light.' Randy on the roasters: 'It's a diverse group. Dr. Brown, who exudes class and dignity. At the other end of the table, Dale Hansen.' Randy Galloway: 'Jerry Jones would have been here. But he's still in New Orleans. The Saints scored again about 30 minutes ago.' Randy Galloway: 'Hammering on Jerry has kept me and Dale employed for years. It's good work and honest work.' And the roast is over. Great time. Great benefit for the Bobby Bragan Foundation. Hit em up. Clarence Hill @clarencehilljr 14m Randy Galloway said he would apologize to john Daniels as soon as he removes knife from Nolan Ryan's back


text:
More than four months ago, Connecticut met Georgia Tech in the semifinals of the Preseason National Invitation Tournament at Madison Square Garden. At the time, they were worlds apart -- the Huskies were the nation's top-ranked team and the Yellow Jackets were expected to finish seventh in the Atlantic Coast Conference.
Now, after each has played almost 40 games, one or the other is one victory from a national title.
When Georgia Tech (28-9) meets UConn (32-6) at the Alamodome on Monday night in the championship game of the N.C.A.A. tournament, that early-season meeting will mean everything and nothing at all.
The Yellow Jackets' 77-61 victory over the Huskies was an epiphany, an especially sweet one for Coach Paul Hewitt, who grew up in Westbury, N.Y., entranced by the Knicks. In seven seasons as a head coach, four at Georgia Tech, he has emulated Red Holzman's brand of ball-sharing basketball, which was effective enough to bring two N.B.A. championships to the Knicks.
Now, Hewitt will find out if his style of basketball is good enough to bring Georgia Tech its first national championship.
''They're coachable and they understand what they have to do to win,'' Hewitt said he believed of his players when they faced UConn in November. ''I can't say that that lesson happened -- that unselfishness came overnight.''Continue reading the main story
It was a liberating defeat for UConn Coach Jim Calhoun, who is in his 32nd season as a Division I head coach and who, in 1999, led the Huskies to the national title.
''I think we had somewhere to shake the shackles, quite frankly, of the expectations,'' Calhoun said, ''and try to make our expectations in our internal barometer be our success mode -- how we felt we played, how we felt we did, not how others were judging us.''
But as for what transpired on the floor, the game was meaningless.
On Nov. 26 at the Garden, Charlie Villanueva had not been cleared to play for UConn by the National Collegiate Athletic Association, which was examining his flirtation with the N.B.A. Rashad Anderson was not a starter. Emeka Okafor was battling acute pain from the back spasms that bothered him for most of the season.
Okafor, the all-American center, was certainly not the dominating presence who scored 18 points in the second half on Saturday night and willed the Huskies to erase an 8-point deficit in the final three minutes of their 79-78 victory over Duke.
Georgia Tech, however, was not at full strength, either. Will Bynum, whose driving layup with 1.5 seconds to play lifted the Yellow Jackets past Oklahoma State, 67-65, in the other semifinal game, was not yet eligible to play after transferring at midterm the previous year from Arizona.
''Both teams are at different stages,'' Georgia Tech guard Marvin Lewis said. ''What happened then doesn't matter -- it's a brand-new game.''
Even if the Huskies are secure in how to measure their success, they are leery of Georgia Tech's nine-man rotation, which features a quartet of cat-quick guards -- Bynum, Lewis, B. J. Elder and Jarrett Jack -- who rotate the ball on offense as precisely as a spider spins a web and who throttle the tempo with the heavy hands of a test pilot.
''Perimeter play is what keeps them going,'' UConn point guard Taliek Brown said. ''They run; they like to get out on the break. They sub three perimeter guards at one time. The people that come off the bench are good, and our focus has to be on stopping them.''
For Georgia Tech, it will be up to the 7-foot-1 center Luke Schenscher to occupy Okafor in the low post on the offensive end so he cannot block the shots of the Yellow Jackets' slashers.
On defense, Schenscher must keep Okafor from moving through the seams for thunderous follow-dunks and short jumpers.
''He's big; he's strong,'' said Schenscher, who had 19 points and 12 rebounds against Oklahoma State. ''He's got great footwork around the basket. He's got great timing blocking shots. You know, he's just an all-round great basketball player on both ends of the floor.''
As much as both teams have evolved over the course of the season and have gained tough victories in the tournament, neither can completely kick the mind-sets that each brought to that Preseason N.I.T. matchup.
Georgia Tech players still believe they have been underestimated. They have won four of their five tournament games by 5 points or fewer, and in the fifth game, the regional final, needed overtime to turn back Kansas, 79-71.
A disappointed Oklahoma State Coach Eddie Sutton went so far as to say that if his team faced the Yellow Jackets in a 10-game series, the Cowboys would come out on top.
''I mean, a lot of teams say that,'' an irritated Jack said. ''We're the team moving on. They're going home. We're playing Monday.''
The Huskies, too, are unapologetic about being named college basketball's best team in the preseason. They are confident, too, that they will finish that way. Asked if he had a chance to sort out how remarkable UConn's comeback against Duke was, Okafor beamed a megawatt grin and let loose with an answer.
''The more we reflect, the bigger our smile gets on our faces,'' he said. ''It was a great comeback, a great game, a great win.
''It's yesterday. It's over. Now let's move on to Monday and start preparing for Georgia Tech and hopefully cut down these nets.''Continue reading the main story


text:
Excel Experts: Question Preview (ID: 13154)
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Each worksheet in a workbook has ________ columns
|a) 256
|b) 782
|c) 300
|d) 20
Each worksheet in a workbook has ________ rows
|a) 100
|b) 202,076
|c) 10,000
|d) 65,536
When you open a new workbook, the default cell is _____
|a) D15
|b) A9
|c) A1
|d) B3
This is the object that represents individual values. It can be a bar, a column, a symbol, an image, or other symbol.
|a) Tick Mark
|b) Data marker
|c) Legend
|d) Plot Area
This is a single value or piece of data from the data series.
|a) Data point
|b) Data Series
|c) Tick Mark
|d) Data Marker
This is a small line or marker on the category(x) and value(y) axes to help in reading the values.
|a) Data Series
|b) Data Point
|c) Data Marker
|d) Tick Mark
This is a collection of related values from the worksheet. These values are in the same column or row and translate into the columns, lines, pie slices and so on.
|a) Data Marker
|b) Gridline
|c) Data Series
|d) Tick Mark
These appear vertically and are identified by letters at the top of the worksheet.
|a) Rows
|b) Columns
|c) Tick Mark
|d) Data Series
These appear horizontally and are identified by numbers on the left side of the worksheet window.
|a) Row
|b) Tick Mark
|c) Data Series
|d) Columns
The intersection of a row and column
|a) Box
|b) Chart
|c) Grid
|d) Cell
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Have you ever wanted to try your hand at making your own beer from scratch? With our dedicated all-grain brewing school you can! Spend the day making your own beer with one of our master brewers as they walk you through the home brewing process from start to finish.
The day includes:


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Dublin man fractured girlfriend's nose with savage punch to face
A man who savagely punched his ex-girlfriend in the face fracturing her nose, causing the nose bone to be exposed and leaving her with a scar has been sentenced to two years in prison.
Christopher Warburton (22) of Montpelier Park, Dublin pleaded guilty at Dublin Circuit Criminal Court to assaulting his ex-girlfriend causing her harm on Kinvara Avenue, Navan Road on September 1, 2015.
Warburton approached his former partner as she walked home from work wanting to speak to her about their break-up several months earlier. When she told him she didn't want to talk to him he grabbed her wrist tightly before telling her to walk with him towards Ashlington Avenue in Dublin.
While he was grabbing her wrist, a man pulled up in a car beside them asking her was she okay. She told the man she wasn't okay and wanted to go home but Warburton wouldn't let her.
Warburton then verbally abused the man and a second person in the car before raising his fist and punching his girlfriend in the nose.
Garda Robert Madden told prosecuting counsel Caroline Cummings BL that Warburton and his former partner had been in a three year relationship but had split up in May 2015.
"Since they broke up they had little or no contact with each other but the defendant would phone her and the conversation would end up in an argument," said Gda Madden.
He said when Warburton approached his ex-girlfriend on the evening and gave her an "unmerciful blow to the nose," she managed to run to a nearby house for help.
She was taken to the Mater Hospital where she was treated for a fractured nose and four stitches as the skin was broken leaving her nose bone visible.
While she was in hospital, Warburton phoned her and claimed he never hit her and didn't know what had happened to her. When she told him she had informed the gardai he called her a 'Rat' and laughed at her, the court heard.
Warburton, who has 16 previous convictions, was on bail at the time of the assault.
In her victim impact statement, the woman said she was now more nervous and is distressed by her current appearance with the scar on her nose.
Defence barrister Marc Kennedy BL, said Warburton didn't take the break-up well and he was trying to resurrect the relationship.
"He apologises to his former partner," said Mr Kennedy, explaining that the defendant had taken cocaine earlier in the day.
"He does have issues with anger but he does have a good side too," said Mr Kennedy, adding that Warburton had a number of job offers for when he was released from prison.
Judge Martin Nolan said the assault was a serious crime.
"He grabbed her and in the course of the struggle savagely punched her in the face fracturing her nose," said Judge Nolan.
"The struggle was interrupted but this did not deter him from punching her."
Nicola Donnelly


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Multi-Purpose Earrings. Beautiful Or Not?
These pair of earrings somehow does what the title says. But its not what you think. Nope, not some high tech gadget or gizmo that runs on battery power. Anyway, the picture below shows it all.
These earrings named Ladybuds crafted with Swarovski crystals, gold, sterling silver and silicone have an additional purpose. They not only look good when worn, but turn into instant earplugs when you place the silicone buds in your ears. Even when the buds are stuffed into the ears, the earrings still retain their exquisite feel. Perfect for the annoying chatterbox or to simply save your ears from noisy environments.
These Ladybud earrings come in two colours, gold or silver and go for US$30 (S$43.61) per pair.


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Ascend is a powerful yet lightweight library for creating rich 3D .NET applications.http://ascend3d.codeplex.com/
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Blender helps to model, shade, animate, render, composite interactive 3d content. Blender's features include 3D modeling, UV unwrapping, texturing, rigging and skinning, fluid and smoke simulation, particle simulation, animating, match moving, camera tracking, rendering, video editing and compositing. It also features a built-in game engine.graphics 3d 3d-graphics video-editor 3d-content animation
Torque 3D is the best full source, open source solution available. orque 3D comes equipped with a full suite of tools to allow your team to excel and produce high-quality games and simulations. Its feature include World Editing Suite, Lighting, Programming, Terrain, Asset pipeline, Networking.games game-engine 3d animation play
Kochol Game Engine(KGE) is an object-orianted hardware accelerated 3D Game engine. Easy to use and powerful engine for cutting edge games.
3D game engine (more powerful redesign of the Cube engine) and FPS game
jMonkeyEngine is a game engine made for developers who want to create 3D games following modern technology standards. It helps to create games that run on any OpenGL 2 and 3-ready device with the Java Virtual Machine – web, desktop, or mobile. It supports Shaders, Lighting, Physics, Special Effects, Texturing, Terrian and lot more.game game-engine java-games texture graphics
Blocks is a 3D tetris variant (yes, another one) using the Crystal Space 3D Engine. It serves as a nice playable game and also an example of a not-too-complex game using Crystal Space.
ColladaCGF enables exporting 3D models into Crysis, using Crytek's resource compiler and Blender/Maya's Collada exporters. Import is partly supported as well, via the Python File Format Interface.
James (a.k.a Java Apache Mail Enterprise Server) is a 100% pure Java SMTP and POP3 Mail server, and NNTP News server designed to be a complete and portable enterprise mail/messaging engine solution based on currently available open messaging protocols.mail-server enterprise mailing-list smtp pop3 nntp
Kyra is a simple, fully featured, industrial strength Sprite engine written in C++. The Kyra engine is suited to 2D, isometric, and quasi-3D games. It is built on top of SDL for cross platform use.
We have large collection of open source products. Follow the tags from
Tag Cloud >>


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Page 8A
Chad imposes curfew after days of violence
Chad's government imposed a dusk-to-dawn curfew across the country Thursday and hunted in the capital for coup plotters after days of fighting left hundreds dead and caused thousands to flee. President Idriss Deby also called for the swift deployment of a European peacekeeping force to guard nearly half a million refugees and Chadians displaced by violence in neighboring Sudan's war-ravaged Darfur region.
Prime Minister Nouradin Koumakoye announced the curfew of 6:30 p.m.-6 a.m. the day after Deby insisted his government had total control of the country after a coup attempt last weekend.
A statement from Amnesty International said the human rights group fears a "major witch hunt." Tawanda Hondora, an official with the group, said there were allegations of summary killings.
Two arrested in attack that killed Bhutto
Pakistani police arrested two more suspects in the suicide attack that killed opposition leader Benazir Bhutto. Interior Ministry spokesman Javed Iqbal Cheema said the two suspects were picked up Thursday in Rawalpindi, where Bhutto died in a gun and bomb attack on Dec. 27. He declined to say whether the two men were key figures in the assassination.
Meanwhile, The New York Times reported on its website late Thursday that investigators from Scotland Yard have concluded Bhutto died after hitting her head as she was tossed by the force of a suicide blast, not from an assassin's bullet. The Times cited unnamed officials who have been briefed on the inquiry.
Dozens arrested in Mafia crackdown
Italian and U.S. authorities arrested dozens of people in a crackdown on the remnants of New York's Gambino crime family, action that was also meant to cripple a trans-Atlantic drug-trafficking operation, federal prosecutor Benton Campbell said in New York.
A federal grand jury accused 62 people of ties to the Gambinos and murders, drug trafficking, robberies, extortion and other crimes dating to the 1970s.
The international operation, code-named "Old Bridge," was centered on New York City and the Sicilian capital of Palermo, said Mike Mershon, head of the FBI's New York office.
Page 8A
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13415 Pleasant View Road, Three Rivers 49093
See more homes for sale in Three Rivers, MI
This property has been Sold!
07/15/2016 at $199,500
PLEASANT LAKE - Lovely ranch home offers airy open floor plan that features a large living room with wood stove, dining room area, and upgraded kitchen. This is a perfect area for your entertaining. French doors lead from open area to a large rear wood deck. The beautiful kitchen comes complete with all appliances. The master bedroom suite is private and offers a whirlpool tub, shower, and private dressing area. The second main floor bedroom is conveniently located beside the 2nd main floor bath. There is new flooring in living room and kitchen area, some ceramic and carpet. The lower level basement boasts of a garden level 3rd bedroom or office with daylight windows, a family room area, third bath, and laundry with washer & dryer. The sandy, private 70 foot deeded lake easement
Property Information
- Status
- Sold
- Address
- 13415 Pleasant View Road
- City
- Three Rivers
- Zip
- 49093
- County
- St. Joseph
- Township
- Fabius Twp
- Possession
- Total Finished SqFt
- 2,067
- Above Grade SqFt
- 1,267
- Garage Desc.
- 2, Attached
- Waterview
- Waterfront Desc
- All Sports, Deeded Access, Shared Frontage, View
- Waterfrontage
- 70.0
- Body of Water
- Pleasant Lake
- Water
- Well
- Sewer
- Septic System
- Year Built
- 1992
- Taxes
- $1,699
Rooms and Land
- MasterBedroom
- 12X12 1st Floor
- Bedroom2
- 11X12 1st Floor
- Bedroom3
- 225X30 Lower Floor
- Bath
- 7X14 1st Floor
- FormalDining
- 13X11 1st Floor
- Kitchen
- 11X11 1st Floor
- Living
- 19X11 1st Floor
- Basement
- Full Basement
- Cooling
- Central
- Heating
- Forced Air, Natural Gas
- Acreage
- 0.56
- Lot Dimensions
- 101.69x243.5
- Appliances
- Dishwasher, Dryer, Microwave, Oven, Range, Refrigerator, Washer
- Fireplace Desc.
- Living, Wood
- Features
- All Window Treatments, Ceiling Fans, Ceramic Floor, Garage Door Opener, Gas/Wood Stove, Whirlpool Tub
- Exterior Materials
- Vinyl
- Exterior Features
- Deck(s), Porch(es)
Listing Video for 13415 Pleasant View Road, Three Rivers MI 49093
Mortgage Calculator
Listing Broker
Listing Courtesy of Berkshire Hathaway Homeservices Michigan Real Esta
Office Address 1200 N Main
Listing Agent Ruth Ann Scott
Listings last updated: . Some properties that appear for sale on this web site may subsequently have been sold and may no longer be available.
Our Michigan real estate agents can answer all of your questions about 13415 Pleasant View Road, Three Rivers MI 49093. Real Estate One, Max Broock Realtors, and J&J Realtors are part of the Real Estate One Family of Companies and dominate the Three Rivers, Michigan real estate market. To sell or buy a home in Three Rivers, Michigan, contact our real estate agents as we know the Three Rivers, Michigan real estate market better than anyone with over 100 years of experience in Three Rivers, Michigan real estate for sale.
The data relating to real estate for sale on this web site appears in part from the IDX programs of our Multiple Listing Services. Real Estate listings held by brokerage firms other than Real Estate One includes the name and address of the listing broker where available.
IDX information is provided exclusively for consumers personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.
All information deemed materially reliable but not guaranteed. Interested parties are encouraged to verify all information. Copyright© 2017 MichRIC LLC, All rights reserved.


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The Parking Garage Gets Its Turn in the Architectural Spotlight
The world's most revered architects are showing their chops in a showdown in America's southeast. The setting for this virtuoso duel is Miami, Florida and the object of attention is the much maligned parking garage.
"The fact that the parking garage has been a neglected form excites some architects, says Bernardo Fort-Brescia, founding principal of Arquitectonica. "That's precisely the challenge-how to turn that garage into something that people love," he says."
"As star architects descend on Miami Beach, they seem to be goading more of their peers to join. "What's happening now is similar to what happened in the Art Deco period, when the city developed a collaborative of architects who played off each other's designs," says William Cary, assistant director of the Miami Beach planning department."


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Holiday Inn Rome Aurelia
Holiday Inn Rome Aurelia
Hotel Guest Rating: 7.1/10
Via Aurelia Km 8,400
Rome 00163
Welcome to the Holiday Inn Rome Aurelia
With an outdoor pool, an airport shuttle, a fitness room and on-site restaurant, the Holiday Inn Rome Aurelia offers essential services in a location approximately 20 minutes from the center of Rome.
Hotel Features
The 10-story Holiday Inn offers 204 rooms with flat-panel TVs, hairdryers, bathrobes and slippers. Check email or make travel plans with the hotel's Wi-Fi, which is available for a fee. Soak in the Italian sunshine with a dip in the seasonal outdoor pool or stay in shape in the fitness room. Road warriors take advantage of the business center, which offers a computer, copy access and fax service. The on-site restaurant provides 24-hour room service. The hotel's shuttle ferries guests to the city's historic area for a fee. Pets are permitted. Non-smoking rooms are available, as is parking.
Hotel Location
The hotel is four miles from the heart of the city, with quick access to Rome's GRA beltway. It is one mile from the Aurelia Metro Station and less than three miles from Vatican City. Step back in time at the magnificent Colosseum and visit the Roman Forum with its ancient columns and arches, both six miles away. The hotel is 17 miles from Leonardo da Vinci-Fiumicino Airport and 10 miles from Rome Ciampino Airport.
Guest Favorites
Priceline guests praise the "friendly personnel" at the Holiday Inn, which offers an outdoor pool, a fitness room and an on-site restaurant four miles from Rome's historic center and Vatican City.
- Internet services
- Fitness centre
- Business centre
- Pets allowed
- Restaurant
- Parking
- Room service
Holiday Inn Rome Aurelia Amenities
- 24-hour front desk
- Accessible parking
- Air conditioning
- Auditory guidance
- Bar
- Bottle of water
- Breakfast in the room
- Business centre
- Children television networks
- Daily maid service
- Designated smoking area
- Dry cleaning
- Emergency cord in bathroom
- Facilities for disabled guests
- Fax/photocopying
- Fence around pool
- Fitness
- Fitness centre
- Free WiFi
- Garden
- Heating
- Higher level toilet
- Internet services
- Ironing service
- Kid meals
- Laundry
- Lift
- Lower bathroom sink
- Luggage storage
- Meeting/banquet facilities
- Newspapers
- Non-smoking rooms
- On-site parking
- Outdoor pool (seasonal)
- Packed lunches
- Parking
- Pets allowed
- Pool/beach towels
- Private parking
- Restaurant
- Restaurant (buffet)
- Restaurant (à la carte)
- Room service
- Safety deposit box
- Secured parking
- Shoeshine
- Shuttle service
- Shuttle service (additional charge)
- Snack bar
- Special diet menus (on request)
- Street parking
- Sun loungers or beach chairs
- Sun umbrellas
- Swimming pool
- Toilet with grab rails
- Trouser press
- Vending machine (drinks)
- Vending machine (snacks)
- Visual aids: Tactile signs
- Wheelchair accessible
- WiFi
- WiFi available in all areas
- Wine/champagne
Hotel Information
Please note that the shuttle service to/from Battistini Metro is at a surcharge.Please note only small pets are allowed. Please note when bringing a pet an extra daily charge of EUR 10 applies.
Hotel Guest Reviews of the Holiday Inn Rome AureliaOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
November 7, 2013
Other than the parking and breakfast costing more money, the hotel was great. The food at the hotel was just fair and not really worth the money. Employees were very helpful, we used public transportation and they helped us with that as well as finding off site dining. I recommend this hotel.
October 28, 2011
Senior Travelers
October 1, 2011
Nice hotel, in a terrible location.
July 11, 2011
Family Traveling with Young Children
July 5, 2011
June 7, 2011
Family Traveling with Young Children
May 18, 2011
Solo Traveler
March 14, 2011
Business Traveler
November 13, 2010
at all. Didn't seem to work correctly.
The hotel was great for the price we paid. Was located a little far from the Central Rome, but with the great transportation system the city has, its not an issue. The room was also very clean, and the staff was generally pleasant.
October 30, 2010
WiFi is not free. Shuttle service is not free. Rooms are to small. Food is good, but overpriced. Had to pay for parking.
(1 - 10 of 10 reviews)
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- Hotel Aureliano from $43 (1.0mi)
- La Giustiniana (7.5 mi)
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- Mentana (12.4 mi)
- Monterotondo (12.6 mi)
- Marino (12.8 mi)
- Villalba (12.9 mi)
- Riano (13.1 mi)
- Formello (13.3 mi)
- Ostia Antica (13.4 mi)
- Pavona (13.5 mi)
- Castel Gandolfo (13.6 mi)
- Sacrofano (13.7 mi)
- Monte Porzio Catone (14.1 mi)
- Albano Laziale (14.2 mi)
- Cesano (14.4 mi)
- Rocca Di Papa (14.5 mi)
- Casaccia (15.1 mi)
- Fregene (15.2 mi)
- Ponte Storto (15.2 mi)
- Castelnuovo Di Porto (15.3 mi)
- Rocca Priora (15.4 mi)
- Lido Di Ostia (15.5 mi)
- Ponton Dellelce (15.8 mi)
- Tivoli (16.0 mi)
- Fiumicino (16.0 mi)
- Gallicano Nel Lazio (16.4 mi)
- Pomezia (16.4 mi)
- Genzano Di Roma (16.7 mi)
- Campagnano Di Roma (17.3 mi)
- Anguillara Sabazia (17.6 mi)
- Colle Di Fuori (17.6 mi)
- Valcanneto (17.8 mi)
- Zagarolo (18.1 mi)
- Fiano Romano (19.1 mi)
- Lanuvio (19.3 mi)


text:
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Langley weighed just two pounds and fifteen ounces at birth, but has not experienced any health problems. The youngster has never been anxious to change his body and does not plan on lifting weights until his high school career is over. Along the same lines, Langley did not begin catching until he entered high school.
"My father didn't want me to catch full time until high school so I could take it easy on my knees," Langley said from his Winston, Georgia home. "I used to be a shortstop, but catching came natural to me."
Langley is still working on the fundamentals of catching, but his arm is one tool that needs no work. The Alexander High School senior has a powerful throwing arm and is now working on the other aspects of catching.
"My arm is the strongest part of my defensive game and lots of scouts have praised me on that. However, my goal is to get my blocking skills better."
Pitchers also fall in love with Langley with the way he calls the game and his knack to keep runners from stealing.
Langley, named after current Yankees manager Joe Torre, batted .459 with three home runs, nineteen runs batted in and also contributed with 39 hits, and 19 runs scored during his junior year of high school. Langley also made the 2005 USA Junior Olympic team.
"The experience with the USA Junior Olympic team was one I will never forget and one of my greatest baseball moments."
However, just last week Langley received more positive news from his high school baseball coach.
"He called me to tell me I was named among the Preseason High School All-Americans."
Langley changed his hitting approach slightly during the AFLAC All-American game this past summer, and as a result it generated more power for him and makes him a complete player.
"I used to be an inside-out hitter, but since the AFLAC game I opened up more and found it creates more power. My motto is to take everything the other way and hit behind runners."
Offensively Langley compares his game to Jorge Posada because he is not a real strong guy, but gets the job done. Defensively, he resembles Ivan Rodriguez – a small catcher in stature, but very productive in all aspects of the game.
Langley is excited about the 2006 First Year Player Draft and his ultimate goal is to be drafed.
"That's what I am working for. For the past three years I trained for this senior season. I hope I get better and better because that is what scouts are looking for. Come June, I hope I get in the draft and picked early."
Langley said he matured faster because he has spent so much time on the road and in hotel rooms since age twelve.
"God has been good to me and my family has been very supportive. I have had no major bumps in the road and I hope that continues.
The issue is not whether or not Langley gets drafted, because barring an injury, he is certain to be an early round pick. T he question remains whether Langley will sign a professional contract or attend Georgia Tech University. Langley selected Georgia Tech over Virginia, Georgia, Miami and Baylor.
"I love the Georgia Tech baseball program. They have a winning tradition, a good educational program and above all my family can watch me play."
Danny Hall, the head coach for Georgia Tech, is very excited about the chance Langley stepping on campus in August.
"Pound-for-pound, Torre Langley may be the best baseball player in the country. He is an excellent catcher and he has one of the best throwing arms that I have seen. His brother (Dustin) was a college baseball player at Georgia Southern. I feel like he's an excellent baseball player, and an excellent catcher. He is the kind of guy that could play a lot of different positions on the field because he is a very good athlete and a great competitor."
Pound For Pound, The Best Catcher
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Amazin ClubhouseMonday at 1:29 PM
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text:
rear bearings
Information and questions on GL1100 Goldwings (1980-1983)
- Sponsored Links
Post Reply
4 posts • Page 1 of 1
- Posts: 26
- Joined: Tue Jun 28, 2011 8:17 pm
- Location: Maumelle,AR.
- Motorcycle: 1984 GL1200I Goldwing, 1982 GL1100 Standard
rear bearings
Can anyone give me a way to remove the rear wheel bearings without purchasing a special tool. It would seem that you would scar everything internally if you tried to punch them out with something. So far I haven't been able to find any info on the process.
- Posts: 26
- Joined: Tue Jun 28, 2011 8:17 pm
- Location: Maumelle,AR.
- Motorcycle: 1984 GL1200I Goldwing, 1982 GL1100 Standard
Re: rear bearings
I found a process on this site for removing rear bearings on an 1100. Seems simple and effective.
- HawkeyeGL1200
- Posts: 918
- Joined: Sat Jul 05, 2014 11:53 am
- Location: Courtland, Va.
- Motorcycle: 1984 GL1200 Interstate
1981 GL1100 Interstate
Re: rear bearings
Honda makes a tool for the retaining nut on the rear wheel. I've been thinking of making one for myself. I've seen the pictures where the person used a pair of needle nose pliers with the tips inserted in two of the spanner holes in the retainer and then used a bar in between the plier tips to loosen the retainer.
I am wrong as often as I am right concerning what is wrong with someone else' motorcycle without having seen the machine in person. Guessing with limited information, as to the source of the trouble, is sketchy at best.
- WingAdmin
- Site Admin
- Posts: 17875
- Joined: Fri Oct 03, 2008 4:16 pm
- Location: Strongsville, OH
- Motorcycle: 2000 GL1500 SE
1982 GL1100A Aspencade (sold)
1989 PC800 (wife's!)
1998 XV250 Virago (sold)
2007 Aspen Sentry Trailer
Re: rear bearings
If you have a look at How to replace your rear wheel bearings, you'll see me demonstrate the use of a simple homemade tool that works well to extract the bearing. I've used the same technique on both wheels of my 1100, 1500 and PC800.
Post Reply
4 posts • Page 1 of 1
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Six great Jools Holland performances
Sep 21
Aforementioned blogging hiatus ongoing, but had a bit of time to do another music post… 1. Eli 'Paperboy' Reed, 2008. And this is why I love Jools Holland. Ahem – Jools Holland's show. Never heard of this guy before, heard very little since, but can he sing? Can he play? HELLS yes. 2. Tori Amos,...Read More


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TY - JOUR T1 - Modeling diffusion of electrical appliances in the residential sector JF - Energy and Buildings Y1 - 2010 A1 - Michael A. McNeil A1 - Virginie E. Letschert KW - Air Conditioners KW - appliance energy efficiency KW - appliances KW - Diffusion rates KW - energy demand modeling KW - modeling KW - refrigerators KW - regression analysis KW - residential KW - televisions KW - Washing machines AB -
This paper presents a methodology for modeling residential appliance uptake as a function of root macroeconomic drivers. The analysis concentrates on four major energy end uses in the residential sector: refrigerators, washing machines, televisions and air conditioners. The model employs linear regression analysis to parameterize appliance ownership in terms of household income, urbanization and electrification rates according to a standard binary choice (logistic) function. The underlying household appliance ownership data are gathered from a variety of sources including energy consumption and more general standard of living surveys. These data span a wide range of countries, including many developing countries for which appliance ownership is currently low, but likely to grow significantly over the next decades as a result of economic development. The result is a 'global' parameterization of appliance ownership rates as a function of widely available macroeconomic variables for the four appliances studied, which provides a reliable basis for interpolation where data are not available, and forecasting of ownership rates on a global scale. The main value of this method is to form the foundation of bottom-up energy demand forecasts, project energy-related greenhouse gas emissions, and allow for the construction of detailed emissions mitigation scenarios.VL - 42 IS - 6 U2 - LBNL-3729E ER -