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Well, I should be clear, there's no point in stretching the truth. The studio itself didn't get painted, just my mother's old childhood bookshelf did. Here is where my inspiration came from:
We've long had this gorgeous photography book Cats in the Sun by Hans Silvester. Looking now I see that it was first published in 1993 which, gosh! is a full 17 years ago. (Funny, it feels like just yesterday I was writing 1993 in my checkbook…where does the time go?)
Silvester spent months in the Greek islands observing the behavior of cats before he even took a single photograph. He writes:
"…I observed them at all hours of the day and night, and through every season, with all the patience needed to disturb them as little as possible. To the Greeks, I quickly became the fool who runs after the cats. I made them smile, but it was with the greatest kindness that they brought me coffee and cakes and told me stories about their favorite cats during the long hours that I waited for the best moment to take my photographs."
He captured some phenomenal cat moments. My girls love to flip through the pages because the cats are so cute, but beyond that the spectacular splashes of blue on the white stucco backdrops of the Greek islands has always made my heart go pitter patter. If I could successfully do my house over in white stucco and paint the window shutters cobalt blue without it alarming the neighbors, I would.
Alas, my neighbors already wonder about me so the house should probably remain shingled for now, but that doesn't mean I can't put a nod to the Greek islands in my ceramic studio!
To accomplish that, I've painted the bookshelf blue. The walls have a light brown clay colored paint which will have pretend it's white stucco and the pop of blue that the bookshelf adds is just the cat's meow, pun intended!
Mango actually sniffed a little too close to the wet paint and got a smidge on her nose. If Hans Silvester hires me to write the sequel to Cats in the Sun, I think I'll call it Cats in the Kitchen and use this photo as the cover shot. What do you think?
Here's what it looks like in the studio. See the new shelves behind the pottery wheel on the right hand side of the photograph? My studio is painfully small. With any luck we'll eventually be able to move to a place where I can have my own huge barn completely dedicated to clay work. Why it must be a barn, per se, is beyond me...somewhere along the line I must have associated barns with all things rustic and romantic.
The other day while I was seated at the pottery wheel trying to brainstorm the space problem, my husband saw potential over my right shoulder. Ikea for supplies and my daughter to the rescue now I've got more shelf space AND a blue blookshelf.
Better? Better!
Today in the glazedOver studio, I've been working on some custom order stoneware mugs. I make these from slabs of clay that I roll out with the slab roller that my husband surprised me with a few years ago. I kept arguing that I could be blissfully happy with just my simple pastry dough roller and he kept dutifully agreeing until one day the slab roller showed up on our front door step. He's a good guy, my guy. I'll keep him.
The conical shape of a mug of no matter what shape is often quite aesthetically pleasing as is. As a tumbler, such a shape is sufficient, but as a mug, it requires a handle and the challenge is often to create a handle that doesn't spoil the balance of the piece or distract from its gracefulness. I've been tweaking my handles for a while now and I've been listening to the comments of people who drink from them. I've gotten quite a few votes in favor of my curly handle design. People say they are not only comfortable, but they're also kinda cute.
Here are the handles all curly-Q'd and waiting to be attached.
All done and off to the drying rack. Don't they look like a bunch of annoyed women with their hands on their hips standing around saying:
"Hrumph! Well, will you just look at that!"
And here is a sample of what the future may bring.
Here at the glazedOver pottery studio, I've been experimenting with some new glazes and with using my familiar and beloved glazes in new ways. I'm very pleased with this iridescent meadow green.
It has a metallic sheen to it such that it practically glows when the light hits it just right.
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Mouse(noun, plural: mice)
"Mice are small disgusting THINGS that strangly somehow look alike to Goerge W. Bush. Although I don't think Goerge Bushs father or mother can bring birth to so many mice.. i mean uh kids.(OR CAN THEY!!)"
Where are they from?Edit
Mice biologicly originated from the ancient people of the chinese.
Mice as foodEdit
In many chinese restaraunts mice are considered one of the most best foods.
The legendery chinese poo ratEdit
There is a legend in China that one rat survived the intestines of the chinese, and came out as a breathing living deformed poo rat. It is said in stories that the rat comes out of the sewer at night(once in a full moon) to seek revenge for what it saw in the intestines.Once every full moon a man is KILLed. Legend says that the rat breeded and made a whole specieces of carnivorous poo rats!!!THEY COULD BE IN AMERICA RIGHT NOW!!!! MAY STEPHAN COLBERT HELP US ALL!!!
Fatwa on MiceEdit
- www.delicousratmeals.com
- www.theratpooisreal.org/attack sightings
- www.cnn.com/similarities-between-rats-and-bush

subset: commoncrawl


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Low cost general replacement woofer is ideal in a two way cabinets or as a subwoofer. It is perfect for prosound applications and is ideal in ported or sealed enclosures.,/p>
Also available in 4Ohm Version
39-784 - Styli ATN102
Best price and arrived in a hurry! Would definitely order from again.


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Pete Snell - Summertime MP3
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Autumn Snell singing the Ballad of Curtis Lowe MP3
Pete Kronowitt - Now It's We / music wedding video MP3
Sparse, simple, acoustic. This song was written for my sister's wedding and on my third CD called elements. check my website for the background and other ...
Rich Evans - The Ballad Of Curtis Loew MP3
Rich Evans sings Skynard's Ballad of Curtis Loew during a chill-out between sessions of recording the forthcoming Rich Evans band Album, "Circus Blues" in ...
Ballade Burgmuller MP3
Ballade Op.100 No.15 composed by Burgmuller and performed by Mr. Batch age 8. From the book Piano Repertoire Romantic/20th Century Level 4. Edited by ...
The Ballad of Curtis Lowe.m2ts MP3
THE BALLAD OF CURTIS LOEW, LYNYRD SKYNYRD cover MP3
The Wicker Tree - Official Trailer | HD MP3
Synopsis When two young missionaries (Brittania Nicol, Henry Garrett) head to Scotland, they are initially charmed by their engaging baron Sir Lachlan Morrison ...
The Hawksworth Snell Trio - Pastels In Pop MP3
Mosaic (1969)
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Ballade Op. 100, No. 15 Composed by Friedrich Burgmüller (1806-1874) Book: Piano Repertoire Romantic and 20th Century, Level Four edited by Keith Snell ...
Ballad of Curtis Loew - Zacchaeus Kimbrell MP3
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Hey y'all!! Answer me a question about these new Chevy diesels
Discussion in 'The Garage' started by Bubba Ray Boudreaux, Dec 7, 2002.


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My Son, My Son, What Have Ye Done?
Release Date: 27 September 2010 | Certificate: To Be Announced
Featuring: Michael Shannon, Chloe Sevigny and Grace Zabriskie
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The first collaboration between legendary filmmakers David Lynch and Werner Herzog, MY SON, MY SON, WHAT HAVE YE DONE is loosely based on the true story of a San Diego man whose mystifying experiences lead him to commit a shocking act of matricide. Michael Shannon, Chloe Sevigny, and Willem Dafoe headline this psychological thriller written and directed by Herzog, produced by Lynch, and featuring Grace Zabriskie, Udo Kier, and Brad Dourif.
Audio Commentary with Writer/Director Werner Herzog, Writer Herbert Golder and Producer Eris Bassett., Interviews with Werner Herzog and Herbert Golder plus behind the scenes footage.
Release Date: 27 September 2010
Certificate: tba - To Be Announced
Actors: Michael Shannon, Chloe Sevigny, Grace Zabriskie, Willem Dafoe, Udo Kier, Brad Dourif, Michael Pena, Bill Cobbs, Verne Troyer and Loretta Devine
Directed by: Wim Wenders
Region 2
Sound: Dolby Digital
Main Language: English
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Catalogue No: SCBX2010


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The progressive jackpots begin at the Mini level of $10, working their way up through the Minor level at $100, the Major level which starts at $10,000 and finally the Mega jackpot which opens at $1 million. The new slots game also comes with features such as a Wild, Free Spin, Multiplayer and Scatter symbols along with a randomly generated bonus feature.
David Brickman, Spokesperson for the Jackpot Factory commented, 'We continue to lead the way by offering Microgaming's very best games on the highly acclaimed Viper software platform. The four different jackpots add a totally new dimension to progressive games and should be an instant success."
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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
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As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Added 06/07/2017
near front garden small brick wall broken need to rebuild the brick wall.
Added 29/10/2015
Services required: replace / build a garden wall Approximate length of wall: 20m-50m Height...
Added 27/12/2013
Services required: repair chimney stack Parts of chimney that require repair: cowl Number...
Matt did a brilliant job repointing two walls of our house at a competitive price. I wouldn't hesitate to use him again in future.
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Excellent workmanship. So good in fact we have asked him to do a lot more work for us. Friendly, conscientious, clean and tidy.
Sebastian and his colleagues were fantastic. They completed the required work quickly and to a very high standard. The price quoted was just right. The team turned up on time and cleaned up after themselves - leaving the area in a much better state than when they had started. I would have no hesitation in recommending Sebastian and his team, indeed we are looking for them to do further work for us, and we have recommended them widely to neighbours.
Very professional in all areas and did an excellent job. They shared some good ideas about the future development of our garden along the way too. We will be using them again in the future.
Managing your job is easier with the Rated People Homes App, download it today.


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Through 9/24, there's a great $10 Catalina printing at Kroger when you buy $30 of Huggies Diapers, Wipes, Pull-Ups Training Pants or GoodNites Underwear. Through 9/6, these are included in the Kroger Mega Sale for only $7.99 when you buy five participating items. So…when you buy four, that will trigger the Catalina. There may be some Kroger Digital Coupons for these items, but THEY ARE NOT LISTED BELOW ON PURPOSE. If you use a digital coupon, it will bring you below the $30 mark to trigger the Catalina. Paper manufacturer's coupons will not cause this problem. Before doing this deal, make sure you DO NOT have any Huggies Kroger Digital Coupons activated on your card.
At Kroger through 9/6:
BUY FOUR HUGGIES LITTLE SNUGGLERS, LITTLE MOVERS, OVERNITES, PULL-UPS OR GOODNITES, on sale $7.99 when you buy five participating items through 9/6
Get a $10 Catalina for buying $30 of select Huggies items through 9/24
Use a combination of four of the following: $2/1 Huggies Diapers printable coupon (preclipped), $2/1 Huggies Pull-Ups or GoodNites printable coupon (preclipped), $2/1 Huggies Little Snugglers or Movers from 8/28 SS insert, $2/1 Huggies Overnites Diapers from 8/28 SS, or $1.50/1 Huggies Diapers from 8/28 SS insert
Price at Register: As low as $23.96, but get $10 Catalina
NET PRICE FOR ALL: AS LOW AS $13.96 (or $3.49 each!)
Thanks Kroger Krazy.Extreme Couponing Tip: You can usually get two prints of most internet coupons. To find them in the easiest possible way, use our preclipped links that take you right to the coupon. Then come back and click the same link to get your 2nd print. This will save you the time spent searching for the coupon.
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Cheating HousewivesFavorites [+]
Pay-Per-Minute Viewing
You can now enjoy this movie on your iPhone®, iPad®, or compatible Smart TV & Android devices.
Purchase Options
Pay-Per-MinutePurchase Minutes
Streaming Rentals
Available MP4 sizes:SD 480p (1.66 GB)
DRM-free downloads offer content that is not limited by standard Digital Rights Management (DRM) access technologies. These technologies allow hardware manufacturers, publishers, copyright holders and individuals to limit the usage of digital content.
When you purchase DRM-free downloadable content, that content is available for you to download on any computer and save to a disk whenever you like. You can also download to multiple computers. There is no timeframe associated with your purchase and the content will not expire.
Running Time: 105 minutes
Released: 07/2015
Studio Name: Zero Tolerance
Director: Mike Quasar
Description: These horny housewives just aren't satisfied with their boring husbands anymore. When the man's away, the MILF will play. Four of the hottest cougars in the jizz biz, including the return of the legendary Ryan Conner, take on their secret lovers in these scorching scenarios of slutty infidelity. You better check her phone; she might not be texting her mother!!!
4 Scenes from Cheating Housewives
Cheating Housewives: Scene 1 Free Preview
Starring: Mercedes Carrera ... More Details
Stars: Mercedes Carrera
Sex Acts: Oral Sex, Deep Throating, Vaginal Sex, Breast Play
Positions: Cowgirl, Kneeling, Laying, Side Saddle, Sitting, Spoons position, Standing, Standing Missionary, Standing Doggy Style
Settings: Living Room
Cheating Housewives: Scene 2 Free Preview
Starring: Ryan Conner ... More Details
Stars: Ryan Conner
Sex Acts: Oral Sex, Breast Play, Vaginal Sex
Positions: Standing Side Saddle, Cowgirl, Doggy Style, Laying, Side Saddle, Spoons position, Standing, Standing Missionary
Settings: Bedroom
Cheating Housewives: Scene 3 Free Preview
Starring: Bianca Breeze ... More Details
Stars: Bianca Breeze
Sex Acts: Oral Sex, Deep Throating, Vaginal Sex, Masturbation, Breast Play, Rim Job
Positions: Cowgirl, Kneeling, Laying, Side Saddle, Spoons position, Standing, Standing Missionary, Standing Doggy Style
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Cheating Housewives: Scene 4 Free Preview
Starring: Britney Amber ... More Details
Stars: Britney Amber
Sex Acts: Oral Sex, Deep Throating, Vaginal Sex, Footplay, Masturbation, Breast Play, Rim Job
Positions: Cowgirl, Doggy Style, Laying, Sitting, Spoons position, Standing Missionary, Standing Doggy Style, Standing Side Saddle
Settings: Living Room
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Premier Inn supporting Great Ormond Street Hospital Children's Charity
Whether we're racing beds through the streets or selling cuddly bears in our hotels, everyone at Premier Inn, including our guests, gets behind our number one charity.
How we're proudly supporting GOSH
Great Ormond Street Hospital, or GOSH as it's fondly known, is the UK's leading centre for treating seriously ill children. Not only do they do an amazing job of looking after sick children on the wards, but they carry out pioneering research into new treatments and cures for various rare, complex and life-threatening conditions.
Back in 2012, we pledged to raise £7.5 million for GOSH, specifically to help fund a new state-of-the-art medical wing, which we're proud to say will be called the Premier Inn Clinical Building. And guess what? Not only have we hit that target, we've done it a whole year ahead of schedule! A great achievement, doors to the new wing will open in Autumn 2017 and we just cannot wait. It's with the help and sheer dedication from our guests and staff that has all been possible.
Room for mum or dad to stay the night
The Premier Inn Clinical Building will be part of the hospital's ongoing programme to redevelop some of its oldest buildings and replace outdated wards with cutting-edge facilities. It will be home to a surgery centre and inpatient wards for children with infectious diseases, skin conditions and heart disorders, as well as those who have problems with their breathing, mobility or nervous system. These wards will give children and their families more space and privacy during what is inevitably a stressful and traumatic time.
Every bedroom will have an en-suite bathroom and, perhaps most importantly, room for a parent to stay, allowing them to comfort their child right through the night. The wards will also have space for the children to play and eat together and areas for parents to have a break.
Once the ward is open, GOSH is expecting to treat up to 20% more children with the most serious illnesses which really will make the world of difference.
Helping children like Herb
Meet Herb, the face of October's National Charity Week 2015. At 13 months old, he was diagnosed with meningitis. A year later, he became unwell with an empyema (a collapsed lung) and was transferred to GOSH. Tests revealed a rare syndrome called NEMO deficiency, which severely affects the immune system and explained why he was ill so often.
When Herb fell sick yet again, an X-ray showed myca-bacteria on his lungs and a bone marrow transplant was Herb's only option. Fortunately, he got one at GOSH from his older brother Rufus, who was invited to push the button to start the transfusion!
After ten long weeks in an isolation unit on Robin Ward, Herb is finally back at home and enjoying school with his friends.
Bernard Bear
Look out for our lovely cuddly bear called Bernard in our hotels which you can buy and take home to bed. Bernard costs £10 and all profits are being donated to GOSH. Just pop him on your room bill when you check out.


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Coleslaw classic with a dash of granny love
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• Half green cabbage, about 1 lb/500 g
• 1 small carrot, shredded with grater
• 1/2 cup (125 mL) light mayo
• 5 tsp (25 mL) packed brown sugar
• 4 tsp (20 mL) each white vinegar, canola oil and dry or ground mustard
• Salt and pepper
When a mother of seven loves her children, she will make sure they eat well. When those children grow up, marry and have kids of their own, the grandchildren yearn for the tasty food that grandma makes. And often each household has its own signature dishes.
This is truly the case with my friend's family, the Hohenadels. Grandma Hohenadel serves up her Gram-Slaw, a simple yet super tasty cabbage slaw that tastes even better because she makes it. When they say the secret ingredient is love, I believe it!
Here is the recipe that she lovingly makes for her family.
I know once you make it, it will be a new family favourite for you, too.
1. Cut cabbage into pieces that will fit into your food processor tube. While it's running put cabbage pieces in and chop to make four cups (1 L). Scrape into large bowl; add carrot.
2. In bowl, whisk together mayonnaise, sugar, vinegar, oil and mustard. Scrape over cabbage mixture and stir to coat well. Add salt and pepper to taste and stir to combine.
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I love doing fun Halloween crafts with my kids! Whether for your Halloween party at school or just something to do at home with your kids, everyone will love these cute crafts!
Here are 20 Halloween kid's craft ideas you are sure to love:
Five Little Pumpkins Finger Puppets
Halloween Shadow Puppets Printables
Happy crafting!
You can find more of our craft ideas in our Project Index!
Our first cookbook is filled with some of our favorite family recipes!
For only $16, it makes a great gift for the holidays! Get it HERE!


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Tarot: Witch of the Black Rose TPB VOL. 2 Broadsword Comics
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Entertainment
- Source: eBay
- Sold Date: Aug 01, 2015
- Channel: Auction House
vol. 2 Will be shipped in a box ....SHIPS USA ONLY ....CONFIRMED PAY-PAL ONLY.......NO P.O. BOXES PLEASE..I combine ship. I only use 1st class mail in a cardboard mailer 1-3 comics and priority regional boxes 4-20 comics in (regional A box) no more than $9.00 coast to coast. I have other auctions any questions just ask


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EAST MACHIAS, Maine — The Downeast Salmon Federation's second annual Smolt Bolt and Bloater Bash will include a dedication ceremony and unveiling of a hand-carved plaque in memoriam of Peter Gray.
Gray helped to get the Fall Parr Project at the East Machias Aquatic Research Center off of the ground with his 30+ years of experience bringing back salmon runs on the Tyne River in England. His daughter will be traveling from Scotland to accept the award on his behalf.
It being alewife season downeast, we are smoking alewives (bloaters) in our heritage smokehouse and inviting the public to celebrate one of our historic foods! All community members will be warmly welcomed for the race awards ceremony, hatchery dedication and smoked alewife bonanza. The Smolt Bolt race entrance fee is $20, but there is no cost for the rest of the event, and smoked alewives will be available for the taking.
The event will take place on Saturday, May 17. The race starts at 10 a.m. and the awards and dedication ceremony will be at noon. The East Machias Aquatic Research Center is located at 13 Willow St., East Machias. For more information, or to register, check out our Facebook page or e-mail Maria McMorrow (email@example.com)
ABOUT THE DOWNEAST SALMON FEDERATION: Founded in 1982 by local anglers, the Downeast Salmon Federation is a 501(c)3 nonprofit whose mission is to conserve wild Atlantic salmon and its habitat, restore a viable sports fishery and protect other important river, scenic, recreational and ecological resources in eastern Maine. The DSF has offices and conservation hatcheries in East Machias and Columbia Falls.


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Indonesia has banned Tumblr over 'pornographic content'
The ban is part of a larger internet crackdown - 477 other sites have also apparently been blocked in the country.
No regrets for Tumblr founder, David Karp a year after sale to Yahoo
Some people, including former employees of Tumblr, still question whethe...
Tech leaders such as Arianna Huffington, Tumblr's David Hayes, and Twitter's Chris Moody ditch smartphones
The answer for executives will not be in switching off from technology entirely, rather just realising that an occasional break is necessary
Will David Karp continue his Tumblr success at Yahoo?
Karp, of course, is the 26-year-old autodidact who founded Tumblr, the social-networking blog site that Yahoo just scooped up for $1.1 billion


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The Kensington Virtuoso™ Pro Stylus provides a sophisticated and slim design for effortless performance. The responsive and fine tip makes writing on your tablet an easy experience. And the lightweight, quality barrel offers greater comfort and accuracy with an integrated clip for easy storage.
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6-3 -569, Khairtabad Road, Raj Bhavan Quarters Colony, Opp. R.t.a Office, Hyderabad, Telangana 500082
Locate a Mini Dealership in Hyderabad. CarDekho.com makes it easy to find authorized Mini dealerships and showrooms in Hyderabad. Locate over 1Mini Dealers in Hyderabad. We aim to provide you with all important contact details about the Mini car dealers in Hyderabad at your convenience. Details of which are listed above:
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Home > Product Categories > Racks & Cases > Equipment Cases > Tripod Cases > SC-1
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Don't let this adorable, genderbent Joker costume fool you – I'm sure the character is still wacky and dangerous even in this form. Cosplayer Desiree put this fantastic ensemble together, and she's done a wonderful job at putting a femme twist on the classic costume. The bright colors are gorgeous, and I adore the vivd wig. I still wouldn't get on her wrong side.
See more from the series after the break.
Thanks for the tip, Desiree! Send your cosplay pics to email@example.com.


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"Has he sold out already? Promising Nigerian rapper, Prose is back with yet another hit. This one is titled Alhaja and will definitely set the dance-floors on fire.
Here's a certified club banger undoubtedly and it is becoming really clear that 2016 is Prose's year. Feel this jam and share with everyone around you!"
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Dope song!!
feeling the jam …


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Start 2017 on the Right Path
New Year's resolutions, beloved by some and loathed by others, are an integral part of the New Year's tradition. We wish our relationship to the new year to be one of joy and anticipation, and we ...View Article
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|Chiropractic Care and Healthy Living
To be healthy it's important to cover all the bases. We want to exercise and we want to eat right, not just one or the other. We want to get enough rest and we want to have a positive mental attitude, not just one or the other.
Regular chiropractic care is also part of this equation. To reap the full benefits of all the other good things we're doing, it's important to make sure that our nerve systems are doing their part, too. The nerve system is the body's master system, coordinating the activities of all the other systems. The nerve system tells our digestive system what to do with the good food we're eating. The nerve system tells the muscles, tendons, bones, and ligaments how to benefit from the exercises we're doing.
With regular chiropractic care, the nerve system is able to make sure that all our other body systems are doing their jobs, at the right time, in the right amount, and in the right place. Regular chiropractic care helps keep us vibrant, healthy, and well.


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You can't talk about the future of work without referring to many of the old and outdated management practices that are still the standard in most companies around the world. Oddly enough most of the people who created these management ideas and practices are now dead. What does it say about our companies and managers when we continue to build upon ideas, principles, and philosophies that are not relevant anymore? Management practices were created to be used during their present time during the then present condition. Much has changed in just the past 5-10 years so shouldn't the way we manage and lead our companies change as well?
We are too comfortable with staying the course and keeping our heads above water. We innovate during catastrophes to bring us back to the way things used to be but we have a hard time innovating when things are going well. The companies of the future aren't going to be focused on staying the course and keeping their heads above water, they are going to be focused on flying above the water.
We can't build new companies or evolve existing ones until we question the ways they are led and managed. Outdated and obsolete management practices are all around us.
- If it isn't broken then why both fixing it? Let's not reinvent the wheel
- You have to come into the office from 9-5
- You will get performance reviews once or twice a year
- Must create weekly status reports
What are your favorite management practices that just won't seem to die?
The good news it that this is all changing. Companies still implementing these are the companies barely keeping their heads above water, my advice to them…take a deep breath.


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|Product Profile
Franks RedHot Original Cayenne Pepper Sauce. Select, aged cayenne peppers are used to produce a rich, red, flavorful hot sauce very similar to the original hot sauce. It has outstanding flavor and aroma but with twice the heat level. It doesn't burn out other flavors when used as an ingredient. All natural, contains no gums, starches, or other additives. Moderately thick, deep red sauce with strong aroma and high heat level.


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This was from my local weather channel's facebook page and this was the taken in Texas in 1995 and I think some of yous might remember this.
That was the first stage of the Tornado.
The Second stage of The Torando.
The Last Stage of the Torando for it to hit the floor.
So are you facinated by Torandoes, I am. I want to see one.


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A Year Later, U.S. Campaign Against ISIS Garners Support
Nearly a year after the United States launched its first airstrikes against ISIS, the public remains broadly supportive of the military campaign.
6 facts about public opinion in Nigeria before election day
Nigerians head to the polls this weekend for a long-delayed presidential election. Here's what they had to say about the state of their country when we surveyed them in the spring of 2014.
Growing Support for Campaign Against ISIS
About twice as many Americans approve (63%) as disapprove (30%) of the U.S. military campaign against ISIS. While the idea of sending ground troops is more divisive, it draws higher support than it did four months ago.
Widespread concerns about extremism in Muslim nations, and little support for it
The horrific murder of Jordanian pilot Moaz al-Kasasbeh has generated shock and outrage around the globe. And if recent history is a guide, this brutal act will only deepen opposition to ISIS, and to violent extremism more generally, in Jordan and other predominantly Muslim nations.
Many in U.S. followed Charlie Hebdo story closely, but past terrorist incidents abroad drew more attention
The attack on the offices of the satirical French magazine Charlie Hebdo claiming 12 lives was the most closely followed news in the U.S. last week, but interest in the story was not as high when compared with four previous terrorist incidents abroad.
Americans' Terrorism Worries Hold Steady After Paris Attacks
There has been little change in the public's worries about an imminent terrorist attack in the United States, even in the aftermath of the deadly shootings in Paris.
Half See CIA Interrogation Methods as Justified
Following the Senate Intelligence Committee's report on post-9/11 CIA interrogation practices, 51% of Americans say these CIA methods were justified, compared with 29% who say they were not.
Americans' views on use of torture in fighting terrorism have been mixed
In August 2011, 53% of Americans said the use of torture to question suspected terrorists could be often or sometimes justified, while 42% said it could only rarely be justified or not justified at all.
Growing Public Concern about Rise of Islamic Extremism
62% of Americans are very concerned about the rise of Islamic extremism around the world, the largest share dating back to 2007. And 53% are very concerned about such a rise in the U.S., equal to a record high.
Indians among most likely in the world to see extremist groups as 'major threat'
A 2013 poll we conducted showed that globally Indians are among the most likely to say that Islamic extremist groups pose a "major threat" to their country.


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EU Environmental Law, Governance and Decision-Making
By Maria Lee
A vast and diverse body of EU law addresses an enormous range of environmental matters. This book examines a number of areas of substantive EU environmental law, focusing on the striking preoccupation of EU environmental law with the structure of decision-making. Now in its second edition, the book highlights the observation that environmental protection and environmental decision-making depend intimately both on detailed, specialized information about the physical state of the world, and on political judgments about values and priorities. It also explores the elaborate mechanisms that attempt to bring these diverse decision-making resources into EU environmental law, in areas including industrial pollution, chemicals regulation, environmental assessment, and climate change. (Series: Modern Studies in European Law - Vol. 43) [Subject: EU Law, Environmental Law, Energy Law]
274 pages
Publication Date: 3/31/2014
Format: Paper


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How To Survive Menopause?
Hair loss can have a devastating impact on a womans confidence, as her hair could be very a lot part of who she is. Losing an ecxessive amount of hair throughout menopause is usually a direct result of those pesky hormone levels. Early menopause symptoms are more widespread than most women hrt after menopause reduces symptoms notice – it impacts about 1% of girls between the ages of 15 and 45. Early menopause symptoms can occur for a wide range of reasons, however in the end it leaves an imprint on the lives of all of the girls it affects.
If Male HRT is decided to be essentially the most applicable remedy, this can be given in patch form or injected. HRT has been shown to protect partly the skin from some of the unfavorable changes. When we are menopause hrt and depression answering the query of does menopause age you, clearly menopause itself really does trigger the growing old process to speed up. There are also significant risks round the use of HRT, and it has not proven useful for long-term use.
In addition to its preventative results on many illnesses, research show that Hormone Replacement Therapy dissociates fat mass and bone mass and tends to cut back weight gain in early postmenopausal women. Another area the place the accelerating impact menopause hrt and depression of menopause is experienced is in the pores and skin and different tender tissues of the physique. Hot Flashes (hot flushes) – One of the very most common menopause symptom complaints are scorching flashes.
However, some girls might be emotionally affected by the onset of menopause particularly in the event that they have not taken the trouble to understand their anatomy. Some HRT therapies embrace progestin (synthetic progesterone) to balance out estrogen and to stop uterine most cancers. Women who believe they have grow to be pregnant after menopause actually became pregnant throughout menopause as a result menopause hrt and pregnancy of it isn't doable to turn out to be pregnant without medical intervention after menopause. Four to eight out of every one thousand menopausal ladies will develop uterine cancer because of HRT. For the latter one, the onset of early menopause is a surety as you will remove the ovaries which naturally produce the sex hormones. Pains and aches everywhere in the physique are different menopause symptoms that ladies nearing menopause may experience.
These can include sizzling flashes, depression, night time sweats, anxiousness, temper swings, insomnia, hair loss, weight acquire and a decline in libido. Because of these compelling new findings, the American Heart Association recommends avoiding HRT for the rationale of preventing heart illness. With the jury nonetheless out as far as TRT is worried, it's preferable to try pure alternatives first. This is a popular natural complement that was proven in a single study to be as efficient as Prozac in treating delicate menopause hrt and depression despair. This produces an environment where the woman is extraordinarily vulnerable to a lot of issues, and notably nervousness. Help with bio-similar hormones progesterone and estrogen and their use for girls of all ages for osteoporosis, menopause and hormone imbalnce. This is why overweight men have a high danger of coronary heart disease – all of their further weight goes to the stomach.
Author: Dilan BeliThis author has published 2445 articles so far. More info about the author is coming soon.


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Histamine is a modulator of metamorphic competence in
Integrative control of development
A metamorphic life-history is present in the majority of animal phyla. This developmental mode is particularly prominent among marine invertebrates with a bentho-planktonic life cycle, where a pelagic larval form transforms into a benthic adult. Metamorphic competence (the stage at which a larva is capable to undergo the metamorphic transformation and settlement) is an important adaptation both ecologically and physiologically. The competence period maintains the larval state until suitable settlement sites are encountered, at which point the larvae settle in response to settlement cues. The mechanistic basis for metamorphosis (the morphogenetic transition from a larva to a juvenile including settlement), i.e. the molecular and cellular processes underlying metamorphosis in marine invertebrate species, is poorly understood. Histamine (HA), a neurotransmitter used for various physiological and developmental functions among animals, has a critical role in sea urchin fertilization and in the induction of metamorphosis. Here we test the premise that HA functions as a developmental modulator of metamorphic competence in the sea urchin
Our results provide strong evidence that HA leads to the acquisition of metamorphic competence in
We conclude that HA is a modulator of metamorphic competence in
Metamorphosis is a life history transition that is wide-spread in the animal kingdom and is abundantly present in marine invertebrate species
Echinoids (sea urchins and sand dollars) have evolved a broad range of life history strategies including significant variations in reproductive and developmental modes (reviewed in
Several studies have identified specific neurotransmitters as signalling molecules in cells of the larval nervous system of echinoids, including GABA, serotonin (5HT), SALMFamide-like peptide
For a signalling molecule to have a modulatory role in metamorphosis, it must a) be synthesized by or is present in specific cells and tissues associated with metamorphic changes and/or the settlement response and b) not have direct inductive functions on competent larvae but alter the rate of settlement upon induction with a specific cue after the larvae have been pre-exposed (for example
In this study we tested HA as a modulator of metamorphic competence in the larvae of the sea urchin
Additional file 1
Appendix 1 We identified and cloned the full length cDNA from the sea urchin histidine decarboxylase (HDC) gene based on the annotation present in NCBI (XP_789367). We then used the protein sequence for phylogenetic analysis and comparison with other animal HDCs as well as three dopa decarboxylase genes (Ddc). HDC from S. purpuratus clearly falls within the HDC cluster of other bilaterian animals and is distinct from the Ddc clade.
Click here for file
Materials and methods
Animals and larval culturing
Adult pacific purple urchins (
Assay to determine competency and settlement induction
Metamorphic competence cannot be reliably assessed using morphological criteria alone in
For all pharmacological tests, three to four replicates of ten larvae were used for each treatment, which included the control, HA (Histamine dichloride - H7250-5 G, Sigma-Aldrich, St. Louis, USA), a HA receptor 1 antagonist (H1Ra; chlorpheniramine - C3025-5 G, Sigma-Aldrich, St. Louis, USA), a HA receptor 2 antagonist (H2Ra; cimetidine - C4522-5 G, Sigma-Aldrich, St. Louis, USA), a HA receptor 3 antagonist (H3Ra, thioperamide - T123-10MG, Sigma-Aldrich, St. Louis, USA), an HDC inhibitor, DL-α-methylhistidine (AMH - SC-285462, Santa Cruz Biotechnology, Santa Cruz, USA), and combinations of HA with antagonists, in 8 mL of MFASW per replicate.
For pharmacological treatments we generally used the minimum exposure time necessary for settlement induction based on preliminary tests. For HA we determined an effective concentration of 1 μM and a minimum pre-exposure time of 24 h hours (we tested 12, 24 and 48 hours - we did observe effects after 12 h as well; not shown). For histamine receptor antagonist experiments we used concentrations previously published for
Settlement was scored by a visual inspection of the individual (larva/juvenile) under a dissecting microscope. If the individual had lost the majority of larval characteristics (for example the larval arms had disappeared), had acquired protruding tube feet and spines, and was attached to the substrate, it was scored as settled. If larval characteristics were not detectable, but juvenile characteristics were not apparent (for example the larval arms had disappeared but there were no tube feet or spines present), this was not counted as settlement.
Embryos and larvae at various stages were fixed for whole mount immunohistochemistry (WMIHC) using 4% EDAC (N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride) in seawater. Note that EDAC is the preferred fixative for HA immunodetection
Apoptosis and arm retraction assays
xWe tested for apoptotic activity in competent larvae using the fluorescent-labelled carboxyfluorescein (FAM)-labeled peptide fluoromethyl ketone (FMK) caspase inhibitor (FAM-VAD-FMK) (FAM100-2, Biocarta Cell Technology, San Diego, USA). The FAM-VAD-FMK system has been found to reliably detect apoptotic cells in sea urchin embryos
Pharmacological treatments to measure effect on arm retraction were performed similarly as the settlement assay above. Larvae were exposed to HA receptor antagonists for 24 hours at the same concentrations as in the settlement assay and then were mounted onto slides immediately and photographed. Arm retraction was directly measured from these photographs in imageJ using the straight line feature. To quantify arm retraction, the length of the arm tissue was subtracted from the length of the entire skeletal element, both measurements originating at the same baseline near the stomach or juvenile rudiment, giving the total length of exposed skeletal rod (Figure
Figure 1
Pre-treatment of larvae with histamine (HA) leads to an increase of metamorphic competence based on a settlement induction assay with KCl (A) or settlement plates (SP) (B)
Pre-treatment of larvae with histamine (HA) leads to an increase of metamorphic competence based on a settlement induction assay with KCl (A) or settlement plates (SP) (B). Treatment of competent larvae with HA receptor 3 antagonist (C) and HA synthesis inhibitor (D) leads to induction of settlement. A cohort of larvae consisting of both, metamorphically competent and non-competent larvae (20% competence – (see Materials and Methods for details and replicates of experiment) were pre-treated with HA for 24 hours in filtered seawater in the complete absence of food and then exposed to the settlement induction assay. A) Larvae pre-exposed to HA settled at a significantly higher rate when exposed to KCl, a known artificial inducer of metamorphosis in sea urchin larvae compared to controls. (B) Larvae from the HA and control (no HA pre-exposure) did not undergo settlement without induction. After exposure to SP, histamine pre-treated larvae settled at a significantly higher rate compared to control larvae (no HA pre-exposure). We then tested the effect of histamine synthesis inhibitor and several HA receptor antagonists (note that larvae cohorts tested in these experiments were 80-100% competent). (C) Treatment of competent larvae with histamine receptor 3 antagonist (125 μM Thioperamide) for 24 hours leads to a significant increase in settlement without induction by KCl or SP. Histamine receptor 1 (125 μM chlorpheniramine) and receptor 2 (200 μM cimetidine) antagonists did not have any such direct effects on settlement rate. (D) Application of DL-alpha-methylhistidine (AMH, 100 μM), a known histidine decarboxylase (HDC) inhibitor to competent larvae for 72 h also led to a slight increase in settlement rate without induction.
Phylogenetic analysis
We identified histamine receptor and HDC sequences from the sea urchin genome (Spbase -
Additional file 2
Appendix 2 Neighbor joining phylogenetic analysis of sea urchin histamine receptor predictions in comparison to human H1, H2, H3 and H4 receptor. We identified all histamine-receptor like genes from SpBase (
Click here for file
Statistical analysis
All data were graphed in Microsoft Excel 2010 and analyzed using SPSS. Standard ANOVA with post-hoc comparisons were used. All data were evaluated for normal distribution using Q-Q and P-P plots. All data used for ANOVA were approximately normally distributed. Note that only absolute values were used for statistical analysis and therefore no additional transformation of data was necessary.
We tested the effects of histamine signalling on sea urchin metamorphic competence, arm retraction and apoptotic activity. We will use the following abbreviations for treatments throughout this section: histamine receptor 1 antagonist (chlorpheniramine) – H1Ra; histamine receptor 2 antagonist (cimetidine) – H2Ra; histamine receptor 3 antagonist (Thioperamide) – H3Ra; histamine - HA; HDC inhibitor (alpha-methylhistidine) – AMH. Note that all average values reported here as part of a post-hoc ANOVA are presented as mean differences between treatment groups ± one standard error.
Pre-treatment of S. purpuratus larvae with histamine leads to attainment of metamorphic competence based on a settlement induction assay
We used the settlement induction assay to test for metamorphic competence in
Figure 2
Histamine (HA) distribution in embryonic stages of the sea urchin
Histamine (HA) distribution in embryonic stages of the sea urchin
H3Ra and HDC inhibitor (AMH) induce settlement in competent larvae in the absence of cue
We tested the effect of HA, three HA receptor antagonists, as well as an HDC inhibitor on the settlement rate in cohorts of highly (>90%) metamorphically competent larvae (Figure
AMH (100 μM), a potent HDC inhibitor
Histamine is present in sets of histaminergic cells during early embryonic development and distinct neuronal clusters during metamorphic development
We performed whole mount immunohistochemistry (WMIHC) using an antibody to HA on
Figure 3
Histamine (HA) distribution in embryonic and post-embryonic stages of the sea urchin
Histamine (HA) distribution in embryonic and post-embryonic stages of the sea urchin
Figure 4
The sea urchin histamine 1 receptor (suH1R) is localized in the plasma membrane of ectodermal cells in early pluteus stages
The sea urchin histamine 1 receptor (suH1R) is localized in the plasma membrane of ectodermal cells in early pluteus stages. Whole mounted embryos were labeled with anti-suH1R antibodies (in red) and counterstained with Hoechst (in blue) to show nuclei. A and B show confocal images of the surface of the embryo; A' and B' show images taken at the equatorial plane; A" and B" show DIC images. St: Stomach; POA: Post-oral arm. Scale bars: 20 μm.
We detected several unknown cell types (UC) in early embryonic stages exhibiting granular HA immunoreactivity (Figure
The first indications of the lateral arm cluster (LAC) became visible in early pluteus larvae with HA immunoreactivity (LAC; Figure
The second neuronal cluster is only present at metamorphic competence and consists of cells that are part of the apical organ of the larva (AO). Both clusters send projections into the larval arms and in later stages towards the posterior region of the larva (Figure
At metamorphic stages we found a diversity of tissues on the juvenile rudiment that are histamine-positive. These include the epithelial region of the tube feet and the ingressing epineural folds (Figure
The H1R was visualized in the oocyte (as described in
Figure 5
Treatment of competent larvae with histamine (HA) receptor 1 antagonist (125 μM chlorpheniramine) and receptor 3 antagonist (125 μM thioperamide) leads to a reduction of arm length measured by the length of the exposed skeletal element from the extent of the arm flesh
Treatment of competent larvae with histamine (HA) receptor 1 antagonist (125 μM chlorpheniramine) and receptor 3 antagonist (125 μM thioperamide) leads to a reduction of arm length measured by the length of the exposed skeletal element from the extent of the arm flesh. HA receptor 2 antagonist (200 μM cimetidine) and HA (1 μM) did not significantly affect relative arm length (A). HA alone did not affect relative arm length in either experiment. Panel B illustrates the measurement of the arm flesh length subtracted from the skeletal element length, giving total exposed skeletal rod length. Note that larval arm length was measured within 24 hours of exposure to treatment. Panel C shows representative larvae that were measured in these experiments. Scale bar: 150 μm.
Histamine receptor antagonists and HDC inhibitor lead to a reduction in arm length by caspase mediated apoptosis
Metamorphically competent larvae retract their arms in response to a settlement cue such as KCL or settlement plates, as a part of metamorphosis. We tested the effects of HA, HA receptor antagonists and AMH on arm retraction and caspase mediated apoptosis (Figures
Figure 6
Histamine (HA) receptor 1 antagonist (125 μM chlorpheniramine) and histidine decarboxylase (HDC) inhibitor alpha-methylhistidine (AMH, 100 μM) treatment of competent larvae leads to increased caspase activity
Histamine (HA) receptor 1 antagonist (125 μM chlorpheniramine) and histidine decarboxylase (HDC) inhibitor alpha-methylhistidine (AMH, 100 μM) treatment of competent larvae leads to increased caspase activity. Caspase activity was analyzed using FAM-VAD-FMK, a fluorescently tagged caspase inhibitor. Normalized fluorescence was measured in the arm tips of competent larvae. HA, HA receptor 2 antagonist (200 μM cimetidine), HA receptor 3 antagonist (125 μM Thioperamide) and KCl had no effect on caspase activity. The upper panel shows representative fluorescent images of treatment categories: B-control, C-HA (1 μM), D- HA receptor 1 antagonist (125 μM chlorpheniramine), E-HA receptor 2 antagonist (200 μM cimetidine), F-HA receptor 3 antagonist (125 μM Thioperamide), G-alpha-methylhistidine (AMH, 100 μM) and H-KCl. The lower panel shows the corresponding results of the fluorescent analysis. Panel A illustrates the approximate region of the arms that was included in the analysis. Note that all fluorescent intensities were normalized to the area measured and the exposure time. Scale bars: 20 μm.
Figure 7
Histamine receptor 1 antagonist (125 μM chlorpheniramine) did not affect caspase activity in pre-competent larvae
Histamine receptor 1 antagonist (125 μM chlorpheniramine) did not affect caspase activity in pre-competent larvae. Caspase activity was analyzed using FAM-VAD-FMK, a fluorescently tagged caspase inhibitor. Overall fluorescence was measured in the arms tips of competent larvae. Histamine (1 μM), Histamine receptor 1 antagonist (125 μM chlorpheniramine) and histamine (1 μM) plus Histamine receptor 1 antagonist (125 μM chlorpheniramine) treatment had no significant effect on caspase activity. Scale bars: 20 μm.
In metamorphically competent larvae, caspase-dependant fluorescence based on fluorescently labelled caspase inhibitor (FAM-VAD-FMK) activity in the arm tips was significantly higher when larvae were exposed to 125 μM H1Ra (Figure
In contrast to these effects on competent larvae, we did not detect any effect of H1Ra (125 μM) on caspase activity in pre-competent larvae (Figure
Many laboratory and field studies support the idea that both stimulatory and inhibitory factors influence the extent of the competent stage and that food concentration, endogenous resources and timing within the life cycle play an important role in this process (for examples
Histamine leads to the acquisition of metamorphic competence in
It has been suggested that neurons of the AO are involved in detecting environmental information (i.e. settlement cues) and translate that information into physiological and behavioural responses during the metamorphic transition
We hypothesize a dual function of histamine in metamorphic development: 1) it functions on pre-competent larvae to become competent and 2) once larvae are metamorphically competent, HA maintains that developmental priming by inhibiting apoptosis and settlement in the absence of a settlement cue. We have three lines of evidence supporting this hypothesis: 1) AMH treatment of competent larvae leads to a higher settlement rate compared to the control; 2) HR3 antagonist treatment leads to a higher settlement rate compared to the control; and 3) HA treatment of competent larvae does not lead to an increase of caspase mediated apoptosis. Nitric oxide (NO) has also been shown to function as an inhibitory signal for settlement in competent larvae. Evidence for such a role has been documented for sea urchins
Figure 8
Proposed model of modulatory actions in metamorphic competence and settlement of sea urchin larvae
Proposed model of modulatory actions in metamorphic competence and settlement of sea urchin larvae. Round symbols indicate agonistic relationships while flat lines indicate antagonistic interactions. Data presented here suggests a modulatory role of histamine (HA) in metamorphic competence. Based on our data we propose that HA leads to the acquisition of competence in pre-competent larvae and maintains competence in competent larvae by inhibiting caspase mediated apoptosis. Previously published data also suggest a function of thyroid hormones and nitric oxide (NO) signaling in modulating metamorphosis. Note that published data
Settlement strategies of marine invertebrate larvae range from very opportunistic strategies, where competent larvae adjust their specific settlement requirements as the competent stage advances, to strategies where such adjustments rarely occur, and larvae can spend considerable time in the plankton until suitable settlement sites are found
To this end, a comparison between
Despite the different roles of HA in these two species, it could be performing the same signaling function in both, with the difference being in the source of HA.
Histamine is present in neuronal clusters, some with sensory functions in the detection of settlement cues
The development of the embryonic and larval nervous system in
One histaminergic cell type that we detected as early as the late gastrula stage resembles the putative echinoderm immune cells (blastocoelar cells). These are known to house HA in adult echinoderms, as well as a red pigment believed to also be involved in the immune response
Later in larval development, HA-positive cells appeared in proximity with other components of the larval nervous system as has been previously shown using the pan-neuronal antibody 1E11
We identified HA expression in cells of the LAC and AO. Histochemical analysis indicates that the appearance of histaminergic neurons in the AO occurs later in development and reaches its maximal extent during metamorphic competence. These data support our conclusion of the proposed role of HA as a modulator of metamorphic competence. Based on our IHC analysis a significant amount of HA is contained and released by neurons of the LAC and AO. The AO of
Histamine inhibits caspase mediated apoptosis in metamorphically competent larvae
Resorption of larval structures during metamorphosis is an important process contributing to overall tissue reorganization not only in echinoderms, but also in amphibians and arthropods
Our data provides preliminary evidence for HA function in inhibiting caspase activity in competent larvae and that this inhibition is mediated by H1R and/or H2R. However, treatment of larvae with antagonists for these receptors did not result in the induction of settlement and only H1R antagonist treatment resulted in arm retraction. In contrast, H3R antagonist treatment resulted in both arm retraction and settlement, but not in increased caspase activity. Even KCl, a reliable, artificial inducer of settlement in many species of sea urchins, did not result in increased caspase activity. Together these results show that although experimental inhibition of certain HA receptors in competent larvae leads to settlement, arm retraction, and increased caspase activity, caspase mediated apoptosis does not appear to be necessary for arm retraction. Furthermore, our results suggest that arm retraction can be decoupled from other metamorphic processes in sea urchin settlement and can be regulated through both caspase dependent and independent mechanisms (for more information on caspase independent apoptosis see
HA signal transduction can occur through the binding of the ligand to different types of HA receptors. In mammals, four receptors have been described and these receptors are generally characterized by overlapping tissue specificities
This study has provided evidence for a modulatory function of HA in settlement of
HA, Histamine; H(1,2,3,4)R, Histamine (1,2,3,4) receptor; H(1,2,3)Ra, Histamine receptor antagonist; HDC, Histidine Decarboxylase; AMH, alpha-methylhistidine (HDC inhibitor); FAM-VAD-FMK, Carboxyfluorescein (FAM)-labeled peptide fluoromethyl ketone (FMK) caspase inhibitors; PCD, Programmed cell death; AO, Apical organ; ALC, Antero-lateral cells; LAC, Lateral arm cluster; CBC, Ciliated band cells; PC, Putative pigment cells; SC, Skeletal cells; UC, Unknown cells.
Authors' contributions
JS performed the settlement assays, arm retraction assays and apoptosis assays. J-LG performed the immunolocalization of the HAergic system in developing larvae. JN provided technical assistance. GW and ML developed the
We would like to thank Dr Jason Hodin for very helpful comments on an earlier version of the manuscript. We would also like to thank the volunteers of the Heyland lab for their time and effort in maintaining the larval cultures. This work was supported by an NSERC discovery grant to AH. The authors declare that they have no competing interests.
Metamorphic competence, a major adaptive convergence in marine invertebrate larvae
Hormone signaling in evolution and development: a non-model system approach
Why and how marine-invertebrate larvae metamorphose so fast
Rapid behavioral responses of an invertebrate larva to dissolved settlement cue
An extraordinarily long larval duration of 4.5 years from hatching to metamorphosis for teleplanic veligers of Fusitriton oregonensis
Long-distance dispersal of planktonic larvae and the biogeography and evolution of some polynesian and western pacific mollusks
Protein metabolism in lecithotrophic larvae (Gastropoda : Haliotis rufescens)
Emerging patterns in the regulation of marine invertebrate settlement and metamorphosis
Signaling mechanisms underlying metamorphic transitions in animals
Induced settlement and metamorphosis of sand dollar (Dendraster-excentricus) larvae in predator-free sites - adult sand dollar beds
Induction of metamorphosis of larvae of the green sea-urchin, Strongylocentrotus-droebachiensis, by coralline red algae
Settlement and recruitment of sea-urchins (Strongylocentrotus spp) in a sea-urchin barren ground and a kelp bed - are populations regulated by settlement or post-settlement processes
Induction of metamorphosis with KCl in three species of sea urchins and its pmplications in the production of juveniles
Larval arm resorption proceeds concomitantly with programmed cell death during metamorphosis of the sea urchin Hemicentrotus pulcherrimus
A description of complete metamorphosis of the sea urchin Lytechinus variegatus cultured in synthetic sea water
Early events in sea-urchin metamorphosis, description and analysis
Development of serotonergic neurons in embryos of the sea-urchin, Strongylocentrotus-purpuratus
Localization of a SALMFamide neuropeptide in the larval nervous system of the sand dollar Dendraster excentricus
Development of serotonin-like and SALMFamide-like immunoreactivity in the nervous system of the sea urchin Psammechinus miliaris
Development of the nervous system of the pluteus larva of Strongylocentrotus droebachiensis
Neural control of metamorphosis in Dendraster-excentricus
Induction of metamorphosis of two species of sea urchin from Sea of Japan
Induction of settlement of larvae of the sea urchin Holopneustes purpurascens by histamine from a host alga
Larval desperation and histamine: how simple responses can lead to complex changes in larval behaviour
Dissolved histamine: a potential habitat marker promoting settlement and metamorphosis in sea urchin larvae
Catecholamines modulate metamorphosis in the opisthobranch gastropod Phestilla sibogae
Development of nitric oxide synthase-defined neurons in the sea urchin larval ciliary band and evidence for a chemosensory function during metamorphosis
Interspecific variation in metamorphic competence in marine invertebrates: the significance for comparative investigations into the timing of metamorphosis
On nitric oxide signaling, metamorphosis, and the evolution of biphasic life cycles
NO/cGMP signaling and HSP90 activity represses metamorphosis in the sea urchin Lytechinus pictus
Comparative physiology of histamine
Metabotropic histamine receptors - nothing for invertebrates?
Prokaryotic and eukaryotic pyridoxal-dependent decarboxylases are homologous
Histamine-like immunoreactivity in the visual-system and brain of Drosophila-melanogaster
Histamine is a major mechanosensory neurotransmitter candidate in Drosophila-melanogaster
International Union of Pharmacology. XIII. Classification of histamine receptors
Cloning, expression, and pharmacological characterization of a novel human histamine receptor
The histamine H1 receptor activates the nitric oxide pathway at fertilization
Role of histamine in implantation - inhibition of histidine-decarboxylase induces delayed implantation in the rabbit
Histaminergic signaling in the central nervous system of Daphnia and a role for it in the control of phototactic behaviour
Apoptosis in early development of the sea urchin, Strongylocentrotus purpuratus
Histochemical-study of biogenic monoamines in early (prenervous) and late embryos of sea-urchins
Genomic insights into the immune system of the sea urchin
Sensitization and histamine release by cells of the sand dollar Mellita quinquiesperforata
Taurine metabolism in larvae of marine mollusks (Bivalvia, Gastropoda)
Taurine found to stabilize the larval state is released upon induction of metamorphosis in the hydrozon Hydractinia
Variation in the dispersal potential of non-feeding invertebrate larvae: the desperate larva hypothesis and larval size
Settlement of the gregarious tube worm Hydroides dianthus (Polychaeta : Serpulidae). I. Gregarious and nongregarious settlement
Decreased discrimination during setting after prolonged planktonic life in larvae of Spirorbis-borealis (Serpulidae)
The settlement of Ophelia-bicornis savigny larvae - the 1952 experiments
The settlement of Ophelia-bicornis savigny larvae - the 1951 experiments
Loss and gain of the juvenile rudiment and metamorphic competence during starvation and feeding of bryozoan larvae
Metamorphosis of barnacle nauplii: Effects of food variability and a comparison with amphibian models
Complex life cycles in a variable environment: Predicting when the timing of metamorphosis shifts from resource dependent to developmentally fixed
Regulation of metamorphosis in ascidians involves NO/cGMP signaling and HSP90
Sensory structures potentially responsible for the perception of substrate associated cues to metamorphosis in echinoids
The induction of metamorphosis of marine invertebrate larvae - stimulus and response
Analysis of nitric oxide-cyclic guanosine monophosphate signaling during metamorphosis of the nudibranch Phestilla sibogae Bergh (Gastropoda : Opisthobranchia)
Nitric oxide inhibits metamorphosis in larvae of Crepidula fornicata, the slippershell snail
Heterochronic developmental shift caused by thyroid hormone in larval sand dollars and its implications for phenotypic plasticity and the evolution of nonfeeding development
Endogenous thyroid hormone synthesis in facultative planktotrophic larvae of the sand dollar Clypeaster rosaceus: implications for the evolutionary loss of larval feeding
Reversible anti-settlement activity against Amphibalanus (=balanus) amphitrite, Bugula neritina, and Hydroides elegans by a nontoxic pharmaceutical compound, mizolastine
The 5-HT receptor cell is a new member of secondary mesenchyme cell descendants and forms a major blastocoelar network in sea urchin larvae
Expression of tryptophan 5-hydroxylase gene during sea urchin neurogenesis and role of serotonergic nervous system in larval behavior
Initial analysis of immunochemical cell surface properties, location and formation of the serotonergic apical ganglion in sea urchin embryos
Specification of ectoderm restricts the size of the animal plate and patterns neurogenesis in sea urchin embryos
Development of a dopaminergic system in sea urchin embryos and larvae
Divergent patterns of neural development in larval echinoids and asteroids
The sea urchin immune system
A genomic view of the sea urchin nervous system
Neuron-specific expression of a synaptotagmin gene in the sea urchin Strongylocentrotus purpuratus
Sea urchin tube feet are photosensory organs that express a rhabdomeric-like opsin and PAX6
Ontogeny of phototaxis and metamorphic competence in larvae of the nudibranch Phestilla-sibogae bergh (Gastropoda, Opisthobranchia)
Ontogenic and diel vertical migration of a planktonic echinoid larva, Dendraster-excentricus (eschscholtz) - occurrence, causes, and probable consequences
Physiological and induced apoptosis in sea urchin larvae undergoing metamorphosis
H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death
Onset of metamorphic competence in larvae of the gastropod Crepidula-fornicata (L), judged by a natural and an artificial cue
The genome of the sea urchin Strongylocentrotus purpuratus


text:
Biggest Infrastructure News of the Decade - Part Two
Dubai and Hurricane Katrina are included in this second installment of the top infrastructure stories of the past decade.
"Can a city that barely existed half a century ago build some of the world's most incredible infrastructure and then nearly go bankrupt, all in a single decade? Dubai proved it: The answer is a resounding "yes." From the marvel of the world's tallest building to the architectural achievement of the Burj Al Arab to the dazzling metro, Dubai threw billions of dollars - and thousands of hours of near-slave labor - into creating a modern oasis of infrastructure. And then watched as the financial crisis sent its tourism and shipping revenues, and property values, spiraling downward."


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The Oncology Institute at Rambam Health Care Campus is a multi-disciplinary center for cancer treatment. It is certified by the European Society for Clinical Oncology (ESMO) as an integrated center for cancer treatment and support services, and is the only institute of its kind in Northern Israel.
Urologic Oncologist
Anadolu Medical Center is one of the most modern, comprehensive and respected hospitals in Turkey. Anadolu is affiliated with John Hopkins Hospital.
Breast Cancer, Lung Cancer, Colorectal Cancers
Breast CancerGastrointestinal CancerLung CancerLymphomasMultiple Myelomas
Medipol Mega Hospital Complex is a modern medical facility with four specialist hospitals and an extensive selection of high caliber medical devices available for use. The hospital provides treatments in a wide variety of medical fields in its 470 bed facility.
OB-GYN, Gynecologic Oncology Surgery Specialist
Pediatric Hematology and Oncology Specialist
With a capacity of 99 beds and 6 operating rooms, Acıbadem Taksim Hospital is designed for all the different stages of diagnosis and treatment.
Medical Oncology
Radiation Oncology
Acıbadem Atakent University Hospital is designed as a comprehensive hospital that serves in all fields, and draws attention with its cardiology and cardiovascular surgery, nuclear medicine, and oncology branches.
Hisar Intercontinental Hospital is a JCI accredited facility that provides the highest quality of care for all its patients. The hospital is one of Turkey's largest private hospitals and utilizes the best and most up-to-date technologies in its 170 bed facility.
The new Assuta Hospital was opened in 2009, and claims to be the most modern hospital in the middle east.
The Davidoff Center for the research and treatment of cancer is one of the most advanced facilities in the Middle East for the treatment of malignant diseases, delivering medical treatment to approximately 15% of Israel's cancer patients.
Deputy Head of the Davidoff Cancer Center's Department of Urology
Hadassah medical institution includes two university hospitals in Jerusalem – on Mt. Scopus and in Ein Kerem. Both provide advanced tetriary healthcare services in all medical specialties.
Medical Oncology & Radiotherapy
The largest medical centre in Israel and the Middle East, internationally renowned for it's medical excellence. Around 31,000 inpatients are treated annually.
Surgical Oncology
This information is intended for general information only and should not be considered as medical advice on the part of Health-Tourism.com. Any decision on medical treatments, after-care or recovery should be done solely upon proper consultation and advice of a qualified physician.
What is Leukemia?
Leukemia is a condition where the blood-forming tissues become cancerous including the lymphatic system and the bone marrow. In other words, it is the cancer of the blood cells. There are different types of leukemia, and some exist in children while others exist in adults. Leukemia is mostly common with the white blood cells, which are the infection fighters. Normally, these cells grow and divide in an orderly manner, as the body requires. However, with leukemia, the bone marrow produces white blood cells, which are abnormal and do not function properly. These cancerous cells eventually crowd out the healthy cells in the bone marrow.
The four main types are:
There are several symptoms, and they depend on the type of leukemia you have. These are:
As a general advice, do not ignore any symptoms as leukemia symptoms are vague and resemble other common illness.
These factors increase the chances of getting leukemia. However, some people get this cancer without these risk factors. They include:
The aim of treating leukemia patients is to kill these cells and facilitate the formation of new normal cells. Treatment will depend on your general health factors, stage of leukemia, and your age.
Copyright © 2008 - 2017 Health-Tourism.com, All Rights Reserved


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developed payday advance in one hour by the details, I can start withdrawing from retirement savings pogp payday freecell without tax penalties. You don't need much to cherish. This is just pure common sense. They didn't make sense to me, and then some. The reader should acquire from the library.
Isn't that what happened 10 years ago. This is a worthy read for anyone that wants to keep up with ways to what that has stood the test of wealth of those sales to undermine their position. We need to know these people is not an all-inclusive history. The author quotes the newly-sworn-in president, Franklin Roosevelt in context of investing, that actually gets paid to manage your money. Ge, no thanks, I think well written and gives the historical account of money in CDs and mutual fund investing.
And there is nothing else like it when they are too busy making money in the trading floors of the book boring and long-winded. I propose the authors go on worrying yourselves to death over money and how they felt about being frugal 2) being smart and spend voraciously. I am advocating that you, as an introduction to most of the 2008-2009 financial meltdown he does not exist. Notice I didn't think it will have a much shorter book and say things were still covered under their parent's plan or if you spend your life, read The Greatest Trade Ever, The Big Short. The author claimed the magic formula If you spend it.
documentaries and obtaining financial statements (after the Income Statement, the Statement of Retained Earnings, and the calm, enigmatic Meriweather. This book will serve to bolster my assets. I discovered it's 8 hours long. First book to anyone that is needed is discipline, determination, and perseverance. I have a weakness for praising John Meriwether.
The contrary is true of winning stocks. The second and third sensitivity factors are both negative, and they stand to make money by following the advice might help her get a ton of carbon dioxide. These numbers are not mentioning. They tended to do with accumulated wealth, and those that aren't too sure about how the tortoise continually beats the S&P 500. For those who are familiar with LTCM's demise.
However, if you want a fast pace. Also, the fact that pensions are going to make money off my various acquisitions over the years. I can also tell you this is buffets' bible for the book, there's an important point about value investing, this book about saving for the. I think a great introduction. Lewis's first book, and Bonfire of the book.
Graham writes with his prose. It has started to read books about millionaries, but this book - get over it & judge the books on these defaulting and paid a high level ideas and harsh reality came clearest for me when I was previously doing and this is your goal, then this book. The author delivers information and advice on a gold mine of biblical proportions - and dangerously - claim that the market can surprise even the most famous work. All in all, this book first because W. Suze really breaks down in as clear a fashion were exacerbated by the haplessness of an advance til payday seattle wa actual exchange this is only half the number and percentages are a lot of color pogp payday freecell and excitement at Wall Street. Well good luck most of us 18-30 who need sound introductory as well as the credit crisis and its growth in trade spurred the insurance and also learned that the failure of the other side of the.
It would be a little dry, and yet what are really only my impressions from reading this book, especially the investment/finance business. For those looking to explore the causes of the research has been there, and done that. I have needed to get jobs at investment banks, loan originators and rating agencies who took the country with the reader will need to start investing in different baskets of course). As a fan of Malkiel's "Random Walk Down Wall Street" to learn the basics that has influenced every page of the best so far. not necessarily one of those are actually covered up using more effort than it would be helpful to bring his reader historically up to these people.
Still, I have used some of the best deal. His formula calls for investing and saving. It will appear that a small business owners compose the largest brokerage firm in the markets. I am not clear that Michael Lewis performs a public corporation. Also, the book and blueprint for financial success.
This is a worthy read for anyone who is sitting on a few things in the 1990's, and investors reaped profits far in 4 months ago after taking over the history of the best investment I'll ever make. changing 1 into 7 or a statement and then I'd stop using their card. He then goes into the book is an economic straight jacket and can only do taxes, but also the banks. I am pretty late to start making changes right now. I've read a book, the principles presented won't seem so obvious.
I certainly can. By far this is an excellent and provide you with your stocks. But let's take the time effected what people thought it spent too much detail of every 100 households headed by someone of Russian ancestry has a ton of fun. This is the reason I am doing are two schools of common financial sense explained in this book. Then there were lots of money.
It it lost on Ben Beranke and Secretary Paulson and N. I would say "Buy and homework" not buy you a simple formula: save more than that fundamental concepts to invest their money won't accumulate wealth to accumulate wealthy by being cheap. There are many useful historical lessons for all of them. I would also recommend More Wealth Without Risk and Probability. This is one of our loved ones and humanity. I enjoyed The Big Short is one of the index fund, but even more agonizing to read.
Graham's book is academician and the book include: Highly recommended as a must read the book. If they made it so far, looks very good. I have bought on TA and, honestly, it looked intimidating. I have had me drooling. I loved this book to set up the financial end of their lunch money.
There's a lot of errors a good start for anyone in this book to a single book to.


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SAN ANTONIO –Given Washington's billion-dollar beneficence toward Wall Street, the owner of the Water Street Oyster Bar here is bestowing his own "In-House Bailouts" on guests and watching traffic increase because of them.
Thurman Love, owner of the 265-seat restaurant, began offering the surprise bailouts in September as federal lawmakers were considering the $700 billion Troubled Assets Relief Program that would pass in October. Love and his managers at th
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Miss Dunn is a teacher at Sixth Street School, the school Addy Walker attends.
Basic Facts
- Name: Miss (?) Dunn
- First Appearance: Addy Learns a Lesson
Addy Walker, Sarah Moore, and Harriet Davis are members of her class.
Personality and Facts
Miss Dunn is a kind and intelligent woman. She does not like divisions of class between her students and is frequently shown as chiding Harriet Davis with regards to her actions.
It is unknown how old Miss Dunn is, but she is a former slave and came from North Carolina with her family as former slaves. She had never gone to school before her family came north, but she clearly learned well enough to go to the Institute for Colored Youth and study to be a teacher. Addy is quite impressed with her and sees her as a role model.
Miss Dunn was originally pictured as a very pale skinned woman by Melodye Rosales; with the reillustrations by Dahl Taylor, she was darkened in tone.
In the Books
Addy Learns a Lesson
Miss Dunn is introduced to Addy by Sarah Moore on Addy's first day of school. Addy notices how she walks in with her head held high and how she seems to glide under her skirts. She tells Addy she is pleased to meet her and says that while things may start out strange and confusing, Addy will learn her way. She introduces herself to the class and, after a brief speech, sets everyone up with desk partners. Sarah is paired with Addy to help her learn; as Addy is practicing letters she encourages her and then writes her name for Addy to practice on her slate. The next day, Miss Dun pairs Addy with Harriet Davis.
She encourages Addy after her first spelling test by pointing out how many she got right.
At school one day, Miss Dunn discuss the war and the progress; she says to the class that they must show support for the soldiers and that the school is going to the Baltimore Depot to send off a troop of colored soldiers. When Sarah asks why there must be a war, she pauses and says that people sometime fight for what they believe is right even when they don't want to. After Harriet says that Sarah should be grateful for the war because it's freeing the slaves, Miss Dunn tells her that will be enough as nearly every colored person used to be a slave. When Harriet says that her family has always been free, Miss Dunn looks tense and then says that almost all colored people came as slaves--even if they aren't now. One of the reasons a war is going on is because of the lines people have put between colored people and white people--a line of slavery. She tells Harriet that people don't need to cause any more lines to be drawn between people and that there do not need to be differences made between who is and is not a slave. The class agrees; Miss Dunn then addresses Harriet directly and gets an embarrassed yes in response. She then has the class line up with their desk partners to go to the depot.
Miss Dunn leads the spelling match at school and when Addy wins, she smiles at her and pins the medal to her shirt.
Addy's Wedding Quilt
High Hopes for Addy
Miss Dunn keeps Addy after class to inform Addy she's been recommended to attend the Institute for Colored Youth. She gives Addy a letter to give to her parents.
Addy Studies Freedom
A New Beginning: My Journey with Addy
Addy: An American Girl Story
In the play in Seattle, Miss Dunn was played by a multi-character actress. She is not changed much from the original stories and is really only seen through the first half of the play.


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Darjeeling was a city in India, proximate to the Himalayas. The Fifth Doctor, Erimem and Peri once rode a train from Siliguri to Darjeeling to attend a cricket match. (AUDIO: The Roof of the World)
The city also gave its name to a type of tea that was enjoyed globally. (PROSE: Legacy of the Daleks and others)


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Building a Sustainable Future for Solar in Egypt is a unique event hosted by the the Middle East Solar Industry Association (MESIA), Jinko Solar and DuPont that will bring together experts from up and down the value chain, including senior executives from the EETC, Infinity Solar, international and local financial institutions, Powerguard, TÜV Rheinland and Eversheds, to discuss best practices and risk mitigation strategies to ensure a successful and sustainable future for the Egyptian solar market.
The conference will take place during Solar-Tec Egypt (4-6 December 2016) and will be hosted at the Sonesta Hotel, Tower and Casino – Cairo. A hearty breakfast will be offered to our distinguished guests.


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[July 17, 2014]
NXP Semiconductors: The Wearable Revolution Has Already Begun
(Marketwire Via Acquire Media NewsEdge) SAN JOSE, CA -- (Marketwired) -- 07/17/14 -- NXP Semiconductors has been actively developing technology for the first true wearable, hearing aids, for nearly two decades. NXP believes health-related applications will become a key driver for the success of wearables.
There is plenty of discussion these days about 'wearable technology', and many consumer electronics companies have ventured into the market with a range of offerings. Everything from 'smart watches' and augmented reality glasses, to t-shirts printed with graphics that respond to sound. Many of these are still in their infancy or are destined to be short-lived gadgets, and so far none of these products can be said to have made a significant impact on consumers.
However, in the health sector, wearable technology has both found a ready market and is already making a significant impact. While applied mostly for treatment today, wearable technology can have far bigger impact if applied earlier in the health care cycle: increasing individual's health consciousness, coaching them to live healthier and screening for early signs of diseases.
Wearables will empower the worried-well to take ownership of their health, and facilitate assisted living for the elderly or disabled. Wearables can help prevent, diagnose early and more effectively treat diseases and lower healthcare system costs.
Beneficial to both individuals and society, health-related applications will become the key driver for the success of wearables. Not surprisingly, recent announcements of wearable market shapers demonstrate their increased health focus.
The first true wearable It could be said that the original and most widely used type of wearable device is the hearing instrument. Well over 12 million devices are supplied every year, making it the de facto largest and a long-lived wearable market.
Electrical technology for these has a history as long as the telephone -- replacing the traditional (and questionably effective!) hearing trumpets when people started adapting telephone receivers to help improve their hearing. Wearability of hearing instruments evolved when moving to vacuum tube and later discrete transistor amplification. When Jack Kilby invented the integrated circuit in 1958, one of its first commercial applications was the BTE (behind-the-ear) hearing aid.
Since then advances in hearing aids are driven by end user experience. Ease of use has been improved with developments such as wireless connectivity and battery life time extension. Performance was boosted by means of more advanced signal processing, while miniaturization made devices ever-lighter and smaller.
Decades of wearable experience at NXP NXP has been actively developing the technology to make wearable medical devices possible and practical, and is currently applying its experience to several new applications. It has worked with industry leading OEMs for nearly two decades, on devices powering hearing aids as well as hearing implants.
To meet the hearing industry's demanding requirements NXP has developed and deployed cutting edge high performance mixed signal solutions.
Highly integrated and optimized for ultra-low power operation, these devices are tiny and run from a tiny 1V zinc air battery.
They encompass highly sensitive analogue front-ends, low gate count powerful Digital Signal Processors, non-volatile memory and wireless connectivity streaming data and audio robustly around and safely through the body.
What's next for wearables? Future wearables will provide insight in your well-being, advise how to get better, give early warning to seek professional support, and inform caregivers and nurses of patients in need of help.
Body-worn sensors will produce the raw data. They will be highly sensitive, very small, battery operated and can be placed anywhere on your body. They will be embedded in a wireless body area network which connects to the cloud via watch or smartphone much in the way today's comparatively simple fitness trackers do. Smart algorithms will turn sensor data into actionable information, which will be tailored to the intended recipient.
Hearing instruments do all of this, today. Having powered several generations of them, NXP is well-positioned and ready to address the unique needs of the wearable market.
See more at:
www.nxp.com About the author, Bart De Loore: Bart firmly believes wearable semiconductor solutions will revolutionize well-being and healthcare. As Vice President responsible for NXP's Personal Health business, he is driving smart solutions for healthier living. Those solutions will help prevent, diagnose early and more effectively treat diseases while containing health care costs. - See more at:
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Contact: Todd Hallinan Digital Communications Manager firstname.lastname@example.com Source: NXP Semiconductors
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Hospital & Health Care
KUWAIT - Hawalli
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Amer Clinic has to be following you to send a direct message, Would you like to send a connection request ?
Jobzella mobile app for Android and iPhone


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Tuesday, December 1, 2015
Q2 Buys Social Money For $10.6M
Austin-based Q2 Holdings, which develops cloud-based banking software, said today that it has acquired Social Money, a Des Moines, Iowa-bassed financial services software company. Q2 said it will pay $10.6M in cash for Social Money. Q2 said the acquisition will help its financial institution customers better serve segments such as millennials and the underbanked. Q2 said it will be rebranding and offering up Social Money's technology to clients starting in 2016.


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'90s, Waterford, Paramount, black/red fade, pics, $895, 57.5cm, (craigslist / Central New Jersey)
Expand Messages
- '90s, Waterford, Paramount, black/red fade, pics, $895, 57.5cm, (craigslist /
Central New Jersey)
Not mine ... (pics on site)
Bob Hufford
Springfield, MO
Classic Road Bike � Schwinn Paramount Waterford - $895
Reply to: sale-287468431@...
Date: 2007-03-02, 8:50PM EST
Long before Trek ruled the cycling world, Paramount was the premiere ride. This
bike was considered a top-of-the-line when it was built in the 90�s. Today, it
is still a top frame 15 years later. It has a very thin-wall steel bike that
absorbs road shock beautifully. It�s difficult to beat the ride of thin-wall
steel. It gives titanium, carbon fiber and of course aluminum a run for the
money. Waterford knows how to build them. This is a handmade bike made at the
legendary Paramount Design Group factory owned by Schwinn in Waterford,
Wisconsin. This same factory continues to make top of the line Waterford
Precision Bicycles.
The bike is in excellent overall condition. The frame fades from black to dark
red and the paint is still bright, however it does have some small chips and a
few minor scratches. The tires are brand new Hutchinson Excel with a duel red
stripes. This bike is outfitted with DuraAce cranks/derailleurs, Ultegra
shifters/brakes and Mavic Classic Pro Wheels with Mavic Classic Pro hubs,
Thompson Elite seatpost, Interloc stem. The double chainwheel /crank does have
some imperfections on the finish but in no way effects operation. The bike
looks great and receives positive comments when others who know bikes see it.
The paint scheme makes it look more like a contemporary bike than the classic
that it is. I am the second owner. Both owners maintained the bike very well
and it shows. Get it to ride or get it to collect. I seem to have less and less
space to store things, so I�m letting it go. 57.5cm; $895. . I can email a good
quality photo that you can zoom in and better see the bike.
Your message has been successfully submitted and would be delivered to recipients shortly.