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The Price Earnings Ratio is perhaps the most commonly used valuation tool. We all know and love the Price Earnings Ratio (P/E Ratio). But do we know what it means? And do we know what in our opinion it should be? We all know how to calculate it: It is Price Divided by Earnings. But that gives you what it is. It does not tell you what it means. To understand what it means, you must understand the Math of the Multiple. And that will allow you to both understand what it means, and calculate what, in your opinion, it should be.
Simply put, the P/E Ratio reflects the present value of future cash flows that a person can expect from each $ of earnings. Mathematically it is expressed as:
$1 * (1 + G%) * (1 - Rr)/(VLT ERP + Rf - G%), where G% is the earnings growth rate, Rr is the reinvestment rate, VLT ERP is the equity risk premium measured as β * (Rm - Rf), Rm is the expected investor return from the market and Rf is the risk free rate.
This formula calculates the present value of future cash flows an investor can expect to receive from future distributions.
To calculate a market multiple most appropriate for you as an investor, means having to have a point of view on your assessment of growth expectations, reinvestment rates, equity risk premiums, return expectations and risk free rates. I have set out below my expectations. You can use your own.
For the market, over the very long-term earnings growth in U.S. has been in-line with nominal GDP growth of around 4.5%. In recent years earnings growth has accelerated to a higher level. This has occurred for two reasons.
The first is that in recent years, companies have started returning capital via share buybacks. When a company buys back shares, earnings per share will rise even if there is no growth in the company's earnings. While earnings per share growth will be higher as a result of buybacks, what we are looking for is the percentage growth in total market earnings. It is a growth in total market earnings, not growth in earnings per share that raises the absolute value of the market. The total value of the company will rise with growth. With buybacks, a smaller number of shareholders may cause the value of each remaining share to rise, even if the worth of the company as a whole does not rise. As a result, the impact of buyback activity on growth is best ignored as far as assessing long-term growth rates is concerned. Buybacks are a mechanism to return value to shareholders, and its impact on the multiple is best assessment as part of market return expectations [Rm].
The second is globalization. With globalization, several companies listed in U.S., including those on the S&P 500, see their earnings growth rates influenced by global growth rates, which are higher than U.S. growth rates.
Global nominal GDP growth potential is about 8% (4.2% real and 3.8% inflation), while U.S. nominal GDP expectations are 4.5% (2.5% real and 2% inflation). In my view the growth potential for the S&P 500 has increased to 6.25% (about 50% from 8% Global Nominal GDP growth and 50% from 4.5% U.S. Nominal GDP growth).
Keep in mind that my nominal Global GDP growth estimates are optimistic by many standards. My estimate of 4.2% real Global GDP growth potential is significantly over the Conference Board estimate of 3.1% for 2014-2019. IMF on the other hand estimates 2014 global GDP growth at 3.7%, with it rising to 3.9% in 2015 - this is more in line with my expectation of a rising trend to a 4.2% real GDP growth potential.
Re-investment Rate
The re-investment rate is that percentage of earnings that a company must re-invest to generate the target growth for future years. If you subtract the re-investment rate from 1, you are left with that percentage of earnings that are available to shareholders. I refer to it as the notional payout ratio which is the amount a company could return to shareholders through dividends, buybacks or re-investment to generate growth higher than market growth rates.
One way to estimate the re-investment rate is by using growth rates and the return on equity we expect companies to earn on incremental equity invested. Simply take the growth rate and divide it by the return on incremental equity invested. If a company can be expected to grow at a 6.25% rate, and it earns a return on incremental equity investments of 13.25%, then it must re-invest 47% of its earnings to generate that growth.
I estimate the return on incremental equity investments at 13.25% based on a historic analysis of as reported earnings divided by the book value since 1999, which is included at the end of this section.
The data on operating earnings, as reported earnings, and book values for the S&P 500 included on the below analysis can be downloaded from S&P Dow Jones Indices website here.
With growth expectations of 6.25% and a 13.25% return on incremental equity, the re-investment rate is expected to be just over 47%, and that leaves a notional payout of 53%.
Over the very long-term, the re-investment rate in U.S. has tended towards 40%. The rise in the re-investment rate to 47% has occurred partly as a result of a rise in the long-term earnings growth expectations from 4.5% to 6.25%, and partly as a result in return on incremental equity rising from near 11%, to an expected 13.25%. The growth acceleration comes about as a result of globalization and access to global markets, while the increase in return on equity comes about as a result of shifts in the composition of the economy from one driven by manufacture to one driven by services.
Source: My Analysis of Data Available for Download on S&P Dow Jones Indices website here.
Risk Free Rate
The risk free rate is the theoretical return on an investment with zero risk over a specified period of time. I tend to use the ten-year US government securities as a measure of the risk free rate. At present the rate is 2.71%. However, over the coming several years, I expect it to rise towards its ten-year median levels of 3.69%, and so I use 3.5% as an estimated risk free rate for the coming five year investment horizon. However, if the long-term growth rates do rise to 6.25% as a result of globalization, as I expect they will, the long-term risk free rate will also rise.
In my view, an appropriate risk free rate should offer a 1.5%-1.6% real return over a composite inflation rate of 2.9% (Global Inflation 3.8% * 50% + U.S. Inflation 2% *50% = 2.9%). That implies a forward risk free rate of 4.5%.
Source: My Analysis of Data Provided By Dr. Robert Shiller Available for Download here.
Expected Market Return
People buy and sell stocks. Stocks make up the market. And the market exists in perpetuity. The owners of the market, be they you or another, will receive dividends, buybacks & real growth of dividend & buyback distributions in perpetuity. That is it, nothing else: your only return expectation is from future corporate distributions. Thus what shareholders can expect to receive by way of returns is the dividend yield, the buyback yield, plus real future growth.
Over the very long-term, the market has delivered returns of 9%. This has been made up of a 4.5% yield from a combination of dividends and buybacks, and another 4.5% through growth. Today with long-term growth expectation creeping up to 6.25% for the reasons expressed in the growth section of this post, I suspect the returns investors expect from the market will be higher.
In recent times, between 12/31/2007 and 9/30/2013, the dividend plus the buyback yield averaged 5.33%. Excluding the 6/30/2009 to 9/30/2009 crisis period, the dividend plus the buyback yield averaged 4.78%.
Over the long-term, with the notional payout ratio declining from 60% to 53%, I would expect the dividend plus the buyback yield to decline from 4.5% to 4%. To that we add 6.25% from growth to arrive at a total investor return expectation of 10.25%. This is the investor return an investor should expect over the long-term if the market is bought at the computed multiple. It is not the return expectation based on where the market is trading at the present point in time.
To run a quick check on expected returns from markets as currently priced you can multiply the earnings by the 53% notional payout, divide the result by market price, and then add 6.25% to the result. For example, with the market at 1,800, and operating earnings at $108, over the long term we can expect 3.2% ($108 * 53%/1800) via the dividend and the buyback yield, and 6.25% from future growth. The result is a total return expectation of 9.45%. This is below target market return expectations of 10.25%, indicating that the market is somewhat expensive.
The information on dividend and buyback yield is based on the data below, which is based on an analysis of the most recent data available on the S&P Dow Jones Indices website, which you can download here.
Source: My Analysis of Data Available for Download on S&P Dow Jones Indices website, which you can download here.
Equity Risk Premium (ERP)
The equity risk premium is the excess return demanded by investors in equity to compensate them for the higher risk associated with equity. It is calculated as the difference between the market return and the risk free rate multiplied by β. Since the market has a β of 1, the equity risk premium for the S&P500 is estimated as the difference between expected market return and the risk free rate. In my view, the very long-term equity risk premium ought to be 5.75% (Rm 10.25% minus Rf 4.5%).
Over the very long-term equity risk premiums have tended to 4.5%, or 50% of the market return expectations, and 100% of growth expectations. My projections imply that forward ERP is 56% of forward market return expectation and 92% of forward growth expectations.
Back to the Multiple: This is Value
Thus the multiple most appropriate for me as an investor is 14. That is $1 * (1 + G%) * (1 - Rr)/(VLT ERP + Rf - G%) = $1 * 106.25% * (1-47%)/5.75% + 4.5% - 6.25%).
We have the target multiple. But what do we multiply it with? Which of the E's is applicable? Is it trailing 12 month earnings, is it current year earnings, is it forward four quarter estimates, is it forward year earnings, is it cyclically adjusted earnings (say an average or median of ten or six year earnings), is it as reported earnings, is it operating earnings?
It is up to you to decide. It should represent the level of earnings from which you expect sustainable growth at the estimated levels to be feasible over the long term. I tend to focus on trailing twelve months and a six year median earnings as action levels.
At present, with 2013 expected to close out with operating earnings of $108 and inflation adjusted six year median operating earnings at $106, I expect 1,485 to 1,515 to be a good buy range to return to allocation. At 1732, a multiple of 16 times, I would be comfortable in the context of historically consistent animal spirits in multiples.
Animal Spirits and the Multiple: This is Price
Over the past several decades, markets delivered returns of 9%, half through a dividend plus a buyback yield, and half through growth. The dividend and the buyback yield has been accomplished with a payout of about 60%. Using these numbers to compute a multiple which would have correctly calculated the present value of future cash flows from each $ of earnings we get 13.98. Yet on average markets have traded at multiple of close to 16. Why?
We are animals. And there are animal spirits at work. Animal spirits tend to squeeze the equity risk premiums as investors accept lower market returns.
Like price, value changes, but the value walks at a more leisurely pace: it changes slowly with the passage of time and performance. You may find that the price cause the markets to be over-valued (or undervalued) for an extended duration. Thus while a market trading at or below the value is a buy signal, the market being higher than value level is not necessarily a sell signal.
Over the years when growth ran at long-term rates of 4.5%, and long-term market returns were delivered at 9%, the market traded at an average multiple of 16. This implies that much of the time investors were satisfied with a return of 7.9%. This implies that the equity risk premium of 4.5% declined to 3.4% as a result of animal spirits.
Since we are creatures of habit, and bond yields are low, we could find investors embracing risk for return. For instance, if today investors were willing to accept a 7.9% return, it would imply a long-term equity risk premium of 3.4% (7.9% minus long-term risk free rate 4.5%). This is in-line with historic equity risk premiums adjusted by the work of animal spirits. Indeed, with current risk free rates at 2.71%, the apparent equity risk premium of 5.2% (7.9% minus current risk free rates 2.7%) is wide compared to long-term equity risk premiums of 4.5%, and to the 3.4% equity risk premium as adjusted for animal spirits. This suggests that while markets are expensive in the context of value, they are not expensive in the context of price.
Today, with the markets trading near 1,800, a multiple of 16.63 trailing 12 month operating earnings, assuming my expectations of 6.25% long-term earnings growth are not misplaced, my market return expectation is 9.44%: a 53% notional payout multiplied by $108 in earnings, divided by 1,800 plus 6.25%. If my growth estimates are incorrect, and growth comes in at 5.65% (Conference Board U.S. Growth 2.4% + 2% Inflation & Conference Board Global Growth 3.1% + 3.8% Inflation implies S&P500 earnings growth of 5.65% {[4.4%+6.9%]/2}), the market return expectation with S&P500 at 1,800 is 8.83%: a 53% notional payout multiplied by $108 in earnings, divided by 1,800 plus 5.65%.
The 9.44% to 8.83% range of return expectations is higher than the 7.9% that has been acceptable to investors in the past. The implied risk free rate expectation using my long-term equity risk premium target of 5.75% is 3.69% (9.44% - 5.75%) to 3.08% (8.83% - 5.75%).
Given that the Conference Board estimates are likely more credible (and certainly more influential) than mine, the current implied risk free rate expectation of 3.08% suggests that the market is vulnerable to a decline if the risk free rate rises from its present level of near 2.7% to 3.08% and beyond. However, unless growth expectations start revising downwards, compared with the recent strengthening of growth expectations, I doubt that the market is priced for a dramatic decline.
This is comforting: at present there is no compelling reason to buy or to sell.
Confronting the Confounding Growth Multiple Conundrum
Look at the mathematical expression: $1 * (1 + G%) * (1 - Rr)/(VLT ERP + Rf - G%). We know that VLT ERP + Rf is the market return expectation. What would we do if the market return expectation was lower than or equal to growth? We get either an incoherent or an insolvable value!
Approaching growth multiples is different, and I'll get into it in a post another day. We have all seen situations where buying a high multiple paid out manifold, as well as situations where buying a high multiple ended in tears. What occurs is not a result of the multiple: the multiple simply is what it is. The outcome is influenced by the accuracy of the various estimates included in the components of the multiple.
Working through the math of the multiple gives you a better chance of seeing whether today's high multiple, will become a lower multiple and a profitable investment tomorrow.
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.


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To register, sign up at BluffEurope.com with the code BLUFF and earn a mere 10 Betfair Poker points (equal to $1 rake) and you will be eligible for the event. The software can be downloaded here..
Online editor for Bluff Europe Dave Bland said of the event: "Annette and Sorel are two of the best online players in the world, and it's a privilege to have them playing in the same tournament. We love giving a little bit back to our readers, so this will be a great chance for them to test their skills against two of the best, as well as make some money!"
If anything, this tournament allows you to play with some truly world class professionals – Annette Obrestad, 19, won the World Series of Poker Europe Main Event at only 18 and is well-known for final tabling the toughest online tournaments. Sorel Mizzi, 21, has earned more than $500,000 at PokerStars and is well known as one of the most feared online players.

subset: commoncrawl


text: Updated from 9:43 a.m. ESTJohnson & Johnson ( JNJ) and Guidant ( GDT) are back at the altar. After saying it wanted out of its $25.4 billion takeover bid following a series of regulatory setbacks, J&J agreed Tuesday to acquire the medical device maker for about $21.5 billion, or $19 billion net of Guidant's cash. The new bid will pay Guidant shareholders $63.08 in cash and stock, down 17% from the old offer of $76 a share. "The board believes that it is in the best interest of shareholders to proceed with the merger agreement at the revised terms," Guidant said. "Our enthusiasm for this merger and its potential continues. This agreement makes sense for Guidant shareholders and its employees." Guidant, whose stock plunged from the low $70s after the first agreement fell apart, rose 8.2% to $62.50. J&J gained 3.8% to $62.83 as the market rendered a positive verdict on the value being transferred under the new price. The new deal, which comes out to $33.25 in cash and 0.493 of a J&J share, was approved by both companies' boards. Guidant shareholders must still approve it before its expected close in the first quarter of 2006. Tuesday's news should end the year's most contentious merger saga, one that has repeatedly confounded shareholders on both sides, led to a last-ditch lawsuit and infuriated a vocal community of merger arbitrage hedge funds. "We are delighted that our companies have reached an accord," J&J said. "Our agreement demonstrates that we remain committed to the goal of together building an extraordinary cardiovascular business that can deliver better medical options sooner to millions of patients." Assuming the deal closes on Jan. 1, J&J CEO Robert Darretta expects the company's 2006 earnings to be cut by 8 cents to 11 cents, excluding noncash charges. He says the deal should be modestly dilutive to 2007 earnings but add strongly to profits thereafter.


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Author Tags: Fiction, Women
Anita Roberts' short fiction in Last Chance Cafe and Other Stories (1993) introduce a character named Anna who grows up "the third girl not born a boy" in a family of six girls with an unpredictable and volatile father. Besides writing about how women survive in a world of confused moral and sexual messages, Roberts has co-ordinated a series of assault prevention programs for women and teens, called SAFE TEEN, in schools throughout B.C.
[BCBW 1992] "Fiction" "Women"


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Back Drag Kits include
- 1" x 6" rubber cutting edge mounted to a black powder coat steel frame
- Set of 3/4" thick abrasion resistant steel wear shoes.
The edge is mounted to the top of the ScoopDogg™ & the shoes are mounted to the front of the side plates. When mounted, and with the ScoopDogg rotated forward, the back drag kit can be used to pull snow away from buildings, docks and other tight places. The kit is bolt-on & removable.


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Though it is perfectly acceptable for college students to span a piece of plywood across cinderblocks and call it furniture, the process often leaves living rooms vulnerable to style critics and karate black belts. Opt for unchoppable pieces with today's Groupon: for $149, you get $500 toward contemporary entertainment consoles from B-Modern.
B-Modern produces contemporary entertainment centers inspired by the art and architecture of the Bauhaus school. Each B-Modern piece has a minimalist look and is made with high-quality medium-density fiberboard and stainless-steel ball bearings that ensure smooth drawer function. The Producer collection includes the BM–661 ($1,080), which features six antislam drawers and red high-gloss accents. Entertainment centers in the Designer ($960) collection are marked by a high-gloss frame and a tempered-black-glass top. Meanwhile, stands in the Choreographer ($860) collection support televisions and other technological devices with a 70.8" base, sliding door, and a large drawer capable of storing one circus contortionist for emergency entertainment in the event of a power outage. If necessary, customers can arrange a visit to the B-Modern warehouse in Chatsworth to view items before purchasing.


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Ayvacık district in Çanakkale is renowned as a transition passage for migrants seeking to cross mostly into European countries illegally. Interior Ministry Directorate General of Migration Management decided to build a larger removal center, in addition to the existing one with 80 people capacity.
The construction of the center, having tendered for 6.7 million liras, is expected to be completed by September 2016. The modern facility will be build upon a 8,315 m2 area, in two blocks and two floors. The project seeks to offer illegal foreigner migrants more humanitarian conditions during the process of removal.
In recent years, the Aegean region has become one of the most favored routes for illegals seeking to cross in to the EU.


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How do I qualify for an account?
You simply need to be a current Hastoe resident. You will need to know your tenant reference number and PIN number for this website (sent out to you in the post on a card) to register.
How many accounts can be set up per tenancy?
Just one currently.
What happens if my details are not validated when I try and register?
Please contact Hastoe Direct on 0300 123 2250 for assistance.
What do I do if I have forgotten my password?
Click on the Forgot Password button and this will send you your password. You will need to enter the email address you registered with. If the website database cannot find the email address you enter it will prompt you to email Hastoe Direct.
How do I change my password or email address for the portal?
Either of these tasks can be done simply on the 'Your online access details' page.
My details are not correct on the portal, what do I do?
This could be due to us holding the wrong information for you, or a problem with the website database. If it is just your phone details are wrong, you can send us the correct number(s) via a form on the portal. If other details are wrong please contact Hastoe Direct via email or phone.
I cannot find a repair I was expecting to see in the repairs log?
The repairs log shows repairs orders logged for your tenancy. It will not show repairs calls that did not result in Hastoe raising a repairs order. It also does not currently show communal repairs or repairs done previous to your tenancy.
What are the question marks on the repairs log screen
This indicates there is hover text. If you move your cursor to the question mark if will give an explanation for the information being shown.
My rent balance is not correct?
The rent balance shown is the rent balance shown on our systems the previous evening. It may be that there are some transactions still outstanding. If you are concerned you can contact Hastoe Direct via email or phone.


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PEmicro is pleased to announce that support has been added to its products for files using version 3 and version 4 of the ELF/DWARF format. This is in addition to existing support for ELF/DWARF version 2 and includes both debug and object information handling. Support for 64-bit objects and structures within the ELF/DWARF files has also been added. Support for these additional file formats is available today in PEmicro's debug, flash programming, and test products.
For users of our Cyclone for Renesas stand-alone programmer, we've made our library of programming algorithms for supported Renesas devices available for download here. As always, if you do not see the algorithm you need for a supported device, you can use this link to request a custom algorithm. The Cyclone for Renesas currently supports the H8, R8C, and M16C families.
We're pleased to announce the release of our latest device drivers. This update includes support for Microsoft Windows XP, Vista, and Windows 7 Operating Systems for both 32-bit and 64-bit architectures, as well as some minor bug fixes.To get started using the drivers:
Run the file drivers_10_install.exe. If you have an older version of our drivers installed, the setup will automatically perform the update.
NOTE: The latest drivers no longer include support for Windows 98 and ME, but P&E will continue to make our older drivers available. Support for PCI devices (e.g., BDM Lightning) and Parallel port devices has been removed for Windows Vista and later, as well as all 64-bit operating systems.P&E drivers allow P&E applications to communicate with P&E hardware via the parallel port, PCI bus, Ethernet, Serial, and USB.
The Cyclone for Renesas includes these features:
NOW AVAILABLE - P&E has introduced the Cyclone Automated Control Package, which allows users to manage multiple Cyclones simultaneously. Any supported devices can be programmed in parallel, even if they are different devices with different data.
Please visit P&E's website for information on the Cyclone Automated Control Package (available separately).
P&E's new CompactFlash Activation License activates the Manage Images Utility on the Cyclone interface so that it can be used with CompactFlash cards.


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Theta Xi Pack 1
Something Greek
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1- Theta Xi compucal sticker
1- Theta Xi paddle keychain
Rush service is available.


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|Presenting the Flags
Last night, at Gypsy Hill Park in Staunton, our family continued a summer kick-off tradition by attending the Stonewall Brigade Band's annual Flag Day concert. On hand as a speaker last night was a representative of the Wounded Warrior Project. As usual, the band did a great job and our family enjoyed a relaxing summer evening featuring patriotic themes and a wonderful affirmation of American Exceptionalism. The Color Guard even presented the Gadsden Flag. Stonewall would be proud. ;o)
|Granddaughters Dancing & Catching Lightning Bugs


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April 2016: Biomarkers of Potential Harm - A Public Workshop
April 4 and 5, 2016
8:30 a.m. to 4:30 p.m.
Food and Drug Administration (FDA)
Center for Tobacco Products (CTP)
FDA White Oak Conference Center
Building 31, Room 1503
10903 New Hampshire Avenue
Silver Spring, Maryland 20993-0002
Archived Webcast:
- Day 1 - April 4
Part 1: April 4 2016
Part 2: April 4 2016
Part 3: April 4 2016
Part 4: April 4 2016
- Day 2 - April 5
Part 1: April 5 2016
Part 2: April 5 2016
Part 3: April 5 2016
Part 4: April 5 2016
Workshop Objective:
FDA/CTP is hosting the second biomarker workshop designed to open the discussion on how to identify and implement the use of biomarkers for the purposes of tobacco product regulation. Biomarkers have broad application at FDA/CTP, including the potential to inform product reviews. For example, studying the effects of tobacco product use on biomarkers may provide information on potential health risks of a new product within a relatively short timeframe. Thus, biomarkers could play a critical role in the review of premarket applications of new tobacco products that may not have long-term epidemiological studies on health risks. A large number of biomarkers exist, but their practical utility in the regulatory context needs to be carefully considered. The objectives of the workshop ("Biomarkers of Potential Harm") are to identify 1) approaches to assessing and selecting biomarkers of potential harm; 2) the processes of identifying biomarkers of potential harm that may be useful in tobacco product regulation; and 3) areas of research which may further strengthen knowledge about biomarkers of potential harm.
Who Should Attend this Workshop?
Scientific and medical experts; other interested participants from academia, public health organizations, federal, state and local government agencies; the tobacco industry; and other interested stakeholders.
Registration to Attend or View Live Webcast of the Workshop:
If you wish to attend the workshop in person or by Webcast, you must register by submitting either an electronic or written request no later than March 14, 2016.
Please submit electronic requests at https://www.surveymonkey.com/r/BoPH. Persons without Internet access may send written requests for registration to Dhanya John (see Contact for Questions, below). Requests for registration must include the prospective attendee's name, title, affiliation, address, email address if available, and telephone number. Registration is free and you may register to either attend in-person or view the live Webcast. Both seating and viewership are limited, so early registration is recommended. FDA may limit the number of registrants from a single organization, as well as the total number of participants, if registration reaches full capacity.
For registrants with Internet access, confirmation of registration will be emailed to you no later than March 21, 2016. Onsite registration may be allowed if space is available. If registration reaches maximum capacity, FDA will post a notice closing registration in our News and Events section.
Presenters and Panelists:
FDA/CTP is interested in gathering scientific information on biomarkers of potential harm from individuals with a broad range of backgrounds on the scientific topics to be discussed at the workshop. We are inviting presenters and panelists to address the pertinent information and provide insight into methods to better answer the questions listed below.
In the context of tobacco regulation and with respect to tobacco-related mortality and morbidity, including cancer, nonmalignant pulmonary disease, and cardiovascular disease:
- Can biomarkers of potential harm offer a valid scientific prediction of longer-term clinical outcomes?
- What criteria, such as biomarker characteristics and pathophysiology, should be considered when identifying, evaluating, and selecting biomarkers of potential harm?
- What are the currently well-established biomarkers of potential harm? What biomarkers have been identified as having the potential to be validated biomarkers of potential harm contingent upon future research and development?
- In clinical trials, surrogate endpoints are used when the clinical outcomes require a very long time to study or when the clinical benefit of improving the surrogate endpoint is well understood. However, rigorous testing is needed to show that these surrogate endpoints can reliably predict, or correlate with, clinical benefit. In other regulatory settings, what validated surrogate endpoints have been used to predict longer-term clinical outcomes? What are the lessons learned from the use of surrogate endpoints?
- What shorter-term clinical endpoints such as lung function tests could also serve as biomarkers of potential harm for longer-term clinical outcomes?
- Of the currently identified biomarkers of potential harm, what are their strengths and limitations in terms of their measurement?
- What factors (e.g., interindividual variation, potential confounders) should be considered in the data analysis and interpretation of biomarkers of potential harm?
- What considerations should be taken into account when selecting biomarkers of potential harm to compare potential health risks across different classes of tobacco products?
- What studies have been conducted using biomarkers of potential harm to compare potential health risks across different classes of tobacco products?
- What biomarkers of potential harm can be considered translational (i.e., might be useful to compare across clinical and nonclinical studies)?
- What are the strengths and weaknesses of using Mode of Action analysis of harmful and potentially harmful constituents (HPHCs) in identifying biomarkers of potential harm?
- How can advancements and findings from newer areas of research such as genomics, metabolomics, and proteomics be applied to the evaluation of the potential health risks of tobacco products in clinical and nonclinical studies? What are the challenges to interpreting and applying data from these newer technologies?
If you are interested in serving as a presenter or panelist, please submit the following information found in the paragraph directly below, along with the topic on which you would like to speak, to email@example.com by February 5, 2016.
To be considered to serve as a presenter, please provide the following:
- A brief abstract for each presentation. The abstract should identify the specific topic(s) to be addressed and the amount of time requested.
- A one-page biosketch that describes and supports the speaker's scientific expertise on the specific topic(s) being presented, nature of the individual's experience and research in the scientific field, positions held, and any program development activities.
Panelists will discuss the scientific presentations and questions listed above. To be considered as a panelist, please provide the following:
- A one-page biosketch that describes and supports the speaker's scientific expertise on the specific topic(s) being presented, nature of the individual's experience and research in the scientific field, positions held, and any program development activities.
FDA Invites Public Comments on Biomarkers of Potential Harm
To present oral comments at the workshop:
For those attending the workshop in person, FDA will hold a public comment session on the above listed topics on April 5, 2016, during which comments from the public will be accepted. If you would like to present during the public comment session, please indicate this at the time of registration and provide the specific topic of your presentation. FDA will do its best to accommodate requests to speak. Individuals and organizations with common interests are urged to consolidate or coordinate their remarks and request time for a joint presentation. FDA will determine the amount of time allotted to each speaker and provide instructions to speakers ahead of the meeting.
Requesters with Internet access and who have submitted a working email address will receive an email regarding your request to speak during the public comment period by March 21, 2016.
Key Dates:
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Center for Tobacco Products
Food and Drug Administration
10903 New Hampshire Avenue, Building 75
Silver Spring, Maryland 20993-0002
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|This is an automatically generated e-mail. To reply, visit: http://git.reviewboard.kde.org/r/106567/
On October 3rd, 2012, 7:12 p.m., Michel Ludwig wrote:Ship It!
On October 3rd, 2012, 9:40 p.m., Eugene Shalygin wrote:Dear Michel, with commit c2a2fe238f8054206cca63d209e480809196739b full parsing is there, but why did you remove files loading without Kate? Project loading is slow... What was wrong with that?
On October 4th, 2012, 6:25 a.m., Michel Ludwig wrote:When KatePart loads a file, it additionally performs auto-detection of the encoding of the file. Thus, the only way of ensuring that Kile's loading of files will give the same results as the one of KatePart would actually be to use the file loading mechanism of KatePart, but that's currently not possible.
On October 4th, 2012, 11:05 a.m., Eugene Shalygin wrote:Thank you for the reply and patch rework (almost complete rework:) If you would point me the problems before, I be happy to help you with that) I see. Indeed I forgot about encodings. But as for me it is quite a large overhead --- creating of KatePart. I still want to solve this situation in one or another way. Because what do I see in calgrind drives me crazy: to load 19 documents Kate initializes myspell 231 times and (in the same time!) hunspell --- 215 times! It is more than 20 invocations of spellchecker initializations per document. This is close to to the point of absurdity. May Kile create so many views per document? If it is not the case, I believe this has to be solved. Right now I see the following possibilities: 1. Use, for instance, KEncodingProber to load document-less files. This can cover majority of encodings. Besides, there, on project loading, where document-less Infos are present, we need to get only structure of includes (or another resources inclusion). Can one expect that user provides localized versions of \include/\input commands? I understand that this way adds some inconsistency between different documents loading pathes, which is not good. It seems to me that KDevelop is using this approach and I did not see any problems with it. However I do not use other than cyrillic single byte encodings (in addition to UTF8). 2. Change KatePart behaviour in order to add possibility to exclude loading config for the document (which can initialize spellchecking, load terminal and who knows what else...) 3. Sort out things in Kate that reads config. I would go for the first one, because it is simple for us, and seems to do less harm than benefit.
On October 4th, 2012, 1:48 p.m., Eugene Shalygin wrote:I would like to add that if one would move towards more sophisticated latex parser, then for sure it must be implemented without KatePart. Kind of vote for number 1 :)
On October 4th, 2012, 7:11 p.m., Michel Ludwig wrote:Hehe, no, even an extended parser would operate on QStrings only ;) I had a closer look at KatePart's file loading code and it seems that if an encoding is preset, no auto-detection is attempted unless some kind of encoding problem occurs. As Kile saves the encodings of project items anyway, all that is necessary is to call 'setCodec' on the QTextStream. This should work in 99.999% of the cases. But can you put the file reading code in the doc manager as well? and use KIO::NetAccess for remote documents? Of course, the ultimate solution would be to add a method to KatePart that can read documents without setting up a full KateDocument...
On October 4th, 2012, 7:22 p.m., Eugene Shalygin wrote:Yes, but not via KatePart --- one can obtain fil contants without it, can not one? Regarding loading: brilliant!! I'll prepare the patch against current master. Do I understand correctly, that you want to call back doc manager for text loading? Maybe it would be better to add parseProjectItem() to parser manager? And we still need to implement encoding guessing for free files? Or to believe that we need to parse fast only project files?
On October 4th, 2012, 7:38 p.m., Michel Ludwig wrote:No, the loading has to be done *only* for project items during the opening of the project. For stand-alone files and once a project item is open in the editor parsing should be done as it is now. We can add methods likde get/setDocumentContents to TextInfo that would allow to set the contents of the document as QStringList (if no document is present). In 'DocumentParserThread::addDocument' we can call 'getDocumentContents' on the TextInfo then, and 'setDocumentContents' can be called in 'loadItem' in the doc manager once the loading is complete. But yes, all the loading should be done inside the doc manager.
On October 5th, 2012, 1:07 p.m., Eugene Shalygin wrote:Okay, I've implemented this scheme. It was easy and fast. But a few questions comes up: 1. Where to clean those m_documentContents? Logicaly it must be done in setDocument(). But this is cynical planning of concurency problems, because QStringList::clear() is not atomic. Guarding m_doc with a mutex would help, but that is too complicated. 2. Who can clear document contents for Infos, that will not be loaded in an editor? Thus I decided to try the following. We add virtual encoding() property to TextInfo (or, perhaps, to Info?). This looks logical, since we have url() there, but as we found, url without encoding does not give access to a contents :). Then, we can return m_doc->encoding() if document is set. We make static QStringList Manager::loadFileContents(const Kurl& url, const QString& encoding). We add QStringList TextInfo::contents() which can either get them from m_doc, or call Manager::loadFileContents() if there is no document set. By doing in this way, we do not store files contents in memory longer, then they are needed and avoid race condition between getting and clearing m_documentContents. The most cumbersome place of this way is a change of Info* constructors to add url and encoding. I will test this for a few more hours and submit, if you agree. Do you?
There are no problems regarding concurrency w.r.t. m_doc. Copies of QStringList passed to the LaTeX parser will be thread-safe copies - this is ensured by Qt, i.e. one can safely modify or even delete m_doc after the corresponding QStringList has been copied to the parser thread. What we should NOT do, however, is call 'Manager::loadFileContents' from TextInfo. The reason being that 'Manager::loadFileContents' might start an event loop (from KIO::NetAccess), and we want to reduce the number of "places" that can launch event loops as much as possible (they are evil!). On the other hand, it is fine that 'Manager::openProjectItem' can launch event loops as we are prepared for it and expect it to happen. So, please just return 'm_documentContents' in 'TextInfo::getDocumentContents' (or maybe even call it 'TextInfo::documentContents()' :) and use 'setDocumentContents' in 'openProjectItem'. Afterwards, 'm_documentContents' can possibly be cleared after the call to 'update' in 'openProjectItem', but please check that 'update' will indeed pass the contents to the parser. Regarding getting the encoding, you can use 'KileProjectItem::getEncoding()' and there is no need to use m_doc->encoding(), just get the document contents from m_doc if it is set (and as it is done now).
- Michel
On September 26th, 2012, 9:12 p.m., Eugene Shalygin wrote:
Review request for Kile.
By Eugene Shalygin.
Updated Sept. 26, 2012, 9:12 p.m.


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Sean Bastian
Young Professional Looking to use Sport and Recreation to Improve the Lives of Others
Location: Oreland PAShare profile
Sean is a recent graduate of Temple University, from the School of Tourism and Hospitality Management. Sean earned his degree in Sport and Recreation Management, graduating magna cum laude. Sean also obtained a minor in General Business Studies from the Fox School of Business and a concentration in Event Leadership. Currently pursuing a career in sports, Sean has a strong interest in event planning, marketing and community relations. The culmination of Sean's academics, industry experience and professional growth have given him the tools to be successful in the industry of Sport and Recreation. Being goal oriented, Sean has many aspirations and achievements he wishes to accomplish. That being said, his mission always remains the same. Sean's mission is to use sport as a service which creates individual experiences that improve the lives of others. Sean is a driven, eager young professional who is searching for an opportunity to show you what he can do.
Work ExperienceEdit
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This interview was done before word got out of an offer from the Gators and Gator Country is trying to contact Cuff to hear what he has to say about that. With my own two eyes I watched Cuff and thought he was the best cornerback of the bunch Friday night. He was among several players that were on the edge of getting an offer from Florida.
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One he loves going against is Troupe. Troupe had a great night too overall, but the two have been mixing it up for quite some time now.
"We have been sparring since our tenth grade year," Cuff said. "I remember it was like 4th and 10 and I played him close and he beat me deep to win the game that year. Last year I played him close the whole game and he ended up with one catch for seven yards in the entire game."
Recruiting fans from the schools he is interested in have to like his competitive spirit. When Cuff comes to the field, the chin strap needs to be buckled. He just isn't going to back down.
Stay tuned as we expect this one to develop to another level very quickly.


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The Request for Initial Proposals (RFIP) closed on Monday 2 March 2015. Nine responses were received and evaluated by an expert panel comprising of two private sector members and two senior public servants.
Four proponents have now been invited to progress to a Final Request for Proposals stage which will close in September 2015 with a successful proponent being announced shortly thereafter. The four companies invited to participate in the Request for Final Proposals stage are (in alphabetical order):
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An industry briefing was held in Alice Springs on 31 October 2014 to launch and explain the project to potential proponents and to outline the competitive bid process.
At the 38th meeting of the Council of Australian Governments on Friday, 10 October 2014, the nation's leaders supported the connection of the Northern and Eastern Gas Markets.
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COAG supported the work being undertaken by the Northern Territory to establish a competitive process for the private sector to bring forward proposals for the construction and operation of a pipeline to connect the Northern and Eastern Gas Markets. COAG agreed that connecting these gas markets is the next step to developing a national gas grid and will contribute to the development of a more national and competitive domestic gas market, helping to improve supply security.
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Greeting of the day! Trust you guys are doing great. I have a question regarding the holiday on 28th Feb 2012 in Noida on account of UP election. Our Director has refused to declare the holiday and has insisted to come the office. So please let us know, is it right or is there any mandatory order from the Govt. which direct the private sector to keep their unit closed on this day. Please respond ASAP. Regards Poonam
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See attached notification. It is resonsibility of all organisations to provide facility for voting
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New timetables for bus, tram and train services in South Yorkshire are available to view or download by clicking on the links in the table below.
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text:
Miner's Lettuce (Claytonia Perfoliata) - 2012-07-02 MP3
Claytonia perfoliata (Miner's lettuce, Winter Purslane, or Indian lettuce; syn. Montia perfoliata). ------------------ De winterpostelein (Claytonia perfoliata, synoniem: ...
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This dissertation seeks to analyse the upsurge of insurgent violence in the North Caucasus following the end of the counter-terrorist operation in Chechnya in 2009. By looking at the development of radical Islam and the impact of the Chechen spillover in the region, this research suggests that these factors should be analysed and contextualized in each republic. By comparing the cases of Kabardino-Balkaria, Ingushetia, and Dagestan, this dissertation seeks to demonstrate the importance of vendetta, criminal activity, religious repression and corruption as local factors that contribute to the increase of violence. By focusing on the case of Dagestan, the author proposes a political ethnographic approach to study the mechanisms and details of religious repression and corruption in everyday life. This analysis permits us to map out the different pathways towards the participation in insurgent groups in Dagestan. By doing so, it demonstrates that one can identify three different generations of insurgent fighters in Dagestan. This dissertation demonstrates that the role of Salafist ideology is often marginal in the early stages of the process of violent radicalisation, and slowly gains importance as the involvement in violence increases. The emphasis should be placed on vengeance and religious repression as crucial triggering factors as they provoke a cognitive opening for young people in Dagestan to engage in violence.
Críticas contribuídas por usuários


text: Posted March 27, 2014 I knew KM was going to bounce after that year. Henson, Barnes, and Zeller were all leaving and I figured he'd leave with his friends. He probably should have stuck around 1 more year. I think next year's Heels could be facing another max exodus. I'm a UNC die hard, but as long as we don't have any repeat situations of what happened last summer, UNC is going to be very, very good next year. They'll be deep enough that if JMM does decide to leave early, we prob wouldn't even miss a beat once every one settled down. If the early reports are true, and MacAdoo is returning..... Paige, JMM, Brice Johnson, maybe Tokoto, and maybe one of the VHT freshmen coming in like Jackson could all leave especially if they have a deep and possible title run. i'll trade a mass exodus for a title. 3 people like this Share this post Link to post Share on other sites


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The title of this article is conjectural. Although this article is based on canonical information, the actual name of this subject is pure conjecture.
- "You won't find her. I mean it. She's a long way from here, so screw you."
- — Anna Meurig's daughter to Major Victor Hoffman
Anna Meurig's daughter was a UIR citizen who lived at Aspho Point.
Raid on Aspho PointEdit
When the COG raided Aspho Point, she told Major Victor Hoffman that her mother wasn't there and they would never capture her. Hoffman decided that he would take her as a bargaining chip to force Meurig to come to them, sending her down to wait in a Marlin on the shore with two other captured scientists.[1] As the Marlins escaped from the facility, two Khimeras attacked the boats, and the one she was in was hit and began sinking.[2] She was struggling to stay above water when Dominic Santiago pulled her up into a sitting position, and transferred her to the other boat.[3] She survived when the Marlin was rescued by a Sea Raven.[4]
- ↑ Gears of War: Aspho Fields pg 231-232
- ↑ Gears of War: Aspho Fields pg 292-297
- ↑ Gears of War: Aspho Fields pg 305-307
- ↑ Gears of War: Aspho Fields pg 312


text:
The New Kid
I had been living in this neighborhood for nine years. I knew every single family on the block. Recently, one of the older men on the block passed. Within three months, a new family had moved in. They seemed nice. They were the typical American family. There was a mom, a dad, a daughter, a son, and a dog. We gave them a week to get settled and then we went over to meet them. They were some of the most polite people on the block. They invited us into their house as soon as we got there.
They had a very nice style to their house. It looked almost like a Victorian style house. We took another few steps in and the dog ran over to greet us. He was a big yellow lab. He jumped all over us and got his slobber all over us. We didn't mind, however. We liked dogs. First the mother introduced herself. She was a businesswoman who worked in New York. We then met the father. He was a game designer who worked in Hartford. After that, the daughter came in. She was cute, my age, and had a great personality. Everything was fine, and then we met the son.
He walked in very slowly. His hands were folded at his groin. His hair was long and over his eyes. He was probably about fourteen. He looked up, waved subtly, and walked away. His parents told us a couple of stories about him. There was one in particular that kind of freaked me out. They said on his old street, he had this friend. It was his best friend. They said that one day, while they were together, his friend was hit by a train. The weirdest thing was that she said that they never hung out near the tracks. Even they were scared. The death looked like an accident, but nothing else fit. Even the family suspected a murder, but there was not enough evidence.
After meeting that family, I was definitely creeped out. I went on my computer and did a whole lot of research on the two kids, the neighborhood, and everything else in the section. I learned a lot of things that scared me even further. The boy's friend wasn't the only death in that area. The area had many deaths within the time period that they lived in the neighborhood. The bodies were found in lakes, on the tracks, and even in their own houses. I started getting scared and suspicious. They all happened after the death of the little boy. The deaths all looked like bad accidents. I didn't believe it though. I had a feeling the boy had something to do with it.
The next day I went to the family's house to talk to them. They welcomed me in and asked what my visit was all about. I was scared to tell them. I said, "It involves your son." They actually seemed quite open to the topic, they asked what I have to say about him. I told them about my research. I told them about how I worried. They didn't call me crazy or anything. They went along with it. It was almost like they had the same suspicion. We eventually agreed to go get the son and question him. We entered his room, but he was gone and the window was open.
We called the cops and told them that a suspected murderer was on the loose. They asked how old he looked and they laughed. They asked further details about the boy so we told them. They immediately stopped laughing and said the words, "We'll get right on it". Now I even think that the cops suspected the boy. The mother said she was going to go look for him. I offered to tag along, but she firmly said no. That had to be the last words she spoke. She promised to keep in touch. She called once every five minutes. After twenty minutes she stopped calling. I got scared.
I went to go look. What I found was terrifying. The car that the mother was driving was crashed into a lake. I went to see the part that was sticking out. I noticed the dead mother in the back seat. It looked as if the crash darted her backwards. There was something keyed into the trunk's door. It said, "Stop searching". I almost did when I saw that. However, something told me to continue. I remembered the locations of the victims. "Lake, tracks, and house". I decided to check out the tracks next. There I saw a cop car crushed next to the train tracks. Both cops were obviously dead. Another message: "The further you come, the higher the victim count". That's where I stopped searching.
I went back to the house to tell the family the bad news. They were devastated about their mother/spouse. They were also devastated, but not surprised, about the child being a serial killer. They knew he killed those people, but didn't have the heart to convict him. Even if he was a serial killer, he was still their son. They also said that I was the push to finally try and convict him. I couldn't help but feel the more recent deaths were my fault.
My Continued Worries
He is still on the loose. He still runs around my city. The victim count still continues to rise. I stopped searching, but others didn't. Every week there is another victim. I still can't shake it. It's still, in my mind, my fault. I will find, and kill him one day.


text:
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text:
Lessons in Digital Literacy
I have a collection of lesson plans which explore the concept of developing digital literacy skills and critical thinking by exploring infographics.
Available from:
- Payhip as PDF (£0.99)
- iBook Store for iOS (£0.99 / $0.99 / €0.99)
Click on the images to find out more
The lessons start with reading and discussion around the topics and then go in to more depth to look behind the information and research the topic area using a range of digital research and presentations tools. The lessons usually conclude with some form of output from the students such as a published text, presentation or their own infographic.


text:
Krishna Bhumi Welcomes you
Krishna Bhumi is a grand township in Vrindavan that offers world class living spaces, right at the feet of Vrindavan Chandrodaya Mandir, the world's tallest Lord Krishna temple and an opportunity to become a part of this unique and spiritual abode, immersed in love and devotion to Krishna.
Krishna Bhumi clients have a huge appeal and attraction towards Krishna Bhumi across the country and the world. Our clients today come from 43 different cities in India and 20 countries across the world. The target clientele are the ones devoted to Krishna and Vrindavan and visit Vrindavan.
Channel Partner Benefits:
Krishna Bhumi believes in creating and supporting Channel Partners in various cities and across the globe and provide them with the best of Pre-Sales Support experience along with an attractive commission scheme / payment terms.
Krishna Bhumi has offices in Delhi, Kanpur, Agra, Vrindavan and Kolkata.
We invite Channel Partners from across the country to join hands as an extension of our sales capability and work towards a mutual and beneficial growth path.
Sign up for our Channel Partner Programme
Contact Details:P: +91 96 96 96 8899 | +91 95556 55000
E: firstname.lastname@example.com
W: www.krishnabhumi.in


text:
Volgar Guest House
Offering a terrace and views of the sea, Volgar Guest House is situated in Loo.
Each room at this guest house is air conditioned and features a TV. Some rooms include views of the mountain or garden.
You will find a 24-hour front desk at the property.
The nearest airport is Adler-Sochi International Airport, 38 km from the property.
- Parking
- 24-hour Front Desk
- Garden
- Terrace
- Non-smoking Rooms
- Airport Shuttle
- Free Parking
- Internet Services
- Express Check-in/check-out
- Library
- Hiking
- WiFi
- Free WiFi
- Air Conditioning
- Designated Smoking Area
- Private Check-in/check-out
- Shuttle Service (surcharge)
- Airport Shuttle (surcharge)
- Shared Kitchen
- Private Parking
- WiFi Available In All Areas
- Street Parking
- Outdoor Furniture
- Shuttle Service


text:
Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
Physical and mental discrimination against disabled veteran
Not sure whay you mean about physical andmental duscrimination. Discrimiation normally when you somone is not treated equally under the law... I would contact the mississipi bar, they can provide names of civil rights attorneys in your area.
This is for general information only. Nothing in this information should be construed as creating an attorney-client relationship nor shall any of this information be construed as providing legal advice. Laws change over time and differ from state to state. These answers are based on California Law.Applicability of the legal principles discussed may differ substantially in individual situations. You should not act upon the information presented herein without consulting an attorney about your particular situation. No attorney-client relationship is established.Ask a similar question
Check with your state bar association. You should check out the National Employment Lawyers Association (NELA) as well.
And keep calling around, as it is often difficult to find someone to sue the feds. The rules are somewhat different and many attys will not practice against the feds.
If you found this Answer to be helpful, please mark it as such. Remember, however, free advice is worth every penny you paid for it. This is only generalized commentary on your question. It is not to be taken as legal advice. I am a lawyer – but not your lawyer! Even "in person" interviews leave attorneys with plenty of questions – the Internet makes it crazy! Thank you Chuck Watson 217.544.6165Ask a similar question
The process for filing a discrimination complaint against the federal government is complicated and counter-intuitive. Because of its special characteristics, I have written a guide to help federal employees navigate the system. Please see my Avvo guide to the EEO complaint process for federal government employees: http://www.avvo.com/legal-guides/ugc/summary-of-federal-employees-eeo-discrimination-complaint-process?published=true.
twitter.com/MikaSpencer *** All legal actions have time limits, called statutes of limitation. If you miss the deadline for filing your claim, you will lose the opportunity to pursue your case. Please consult with an experienced employment attorney as soon as possible to better preserve your rights. *** Marilynn Mika Spencer provides information on Avvo as a service to the public, primarily when general information may be of assistance. Avvo is not an appropriate forum for an in-depth response or a detailed analysis. These comments are for information only and should not be considered legal advice. Legal advice must pertain to specific, detailed facts. No attorney-client relationship is created based on this information exchange. *** Marilynn Mika Spencer is licensed to practice law before all state and federal courts in California, and can appear before administrative agencies throughout the country. She is eligible to represent clients in other states on a pro hac vice basis. ***Ask a similar question
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text:
My Notes:
This home plan could reduce your energy costs »
From 1604 exit Shaenfield Rd and head west. Shaenfield will turn into Galm Rd. Continue on Galm Rd and pass Rd 1560. Once you pass Rd 1560, Bricewood will be on right hand side about 1/4 of a mile.
If using a GPS device please use: 11615 Galm Rd, San Antonio, TX 78254
Your friends with be Greene with envy when they visit you in this stunning 2 story, master down home. The open kitchen features beautiful 42" cabinets with decorative tile backsplash and granite countertops. The master bath will not disappoint with a spacious closet and mud set shower! Flexible spaces make this home a real value. Resilient hand laid tile is found in all the wet areas, and even in the family room! Enjoy time with family and friends in your back yard from your covered rear patio! Bricewood boasts a true value with fantastic standard features!


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I'm In The Gloryland Way (1 of 7) by Wayne Hinson
This content is part of a series.I'm In The Gloryland Way (1 of 7)
Series: High Notes of Higher Living Volume One
Wayne Hinson
Psalm 119: 1 thru 8
1. The Gloryland Way Is The Holy Way
A. One of Cleansing
1. By Our Privilege
2. On Our Platform
3. By Our Progression
B. One Of Caring
1. Caring And Keeping
2. Caring And Seeking
3. Caring and Reaping
C. One Of Controlling
1. Our Sinful Aims
2. Our Slothful Attitudes
3. Our Sole Alignment
2. The Gloryland Way Is The Harmony Way
A. Allegiance Results In Accountability
1. A Careful Allegiance
2. A Concentrated Allegiance
3. A Complete Allegiance
a. Authority Of Our Master
b. Aim Of Our Motives
B. Alignment Results In Accessibility
3. The Gloryland Way Is The Hallelujah Way
A. A Hallelujah Attitude
B. A Hallelujah Aptitude
C. A Hallelujah Altitude
Intro: Verses 1-8 begin this wonderful Psalm with the theme of higher living. In the realm of church life today, we are experiencing a trend of low living. One should realize that low living will never yield high returns of blessings from God. The Psalmist's explanation of the "Glory land Way" is exemplified in his expressions of three main words:
1) "Undefiled in the way" (verse 1)
2) "walk in His ways" (verse 3)
3) "O that my ways were directed (verse 5)
1) "Keep His testimonies" (verse 2)
2) "directed to keep" (verse 5)
3) "I will keep" (verse 8)
1) "walk in the law" (verse 1)
2) "walk in His ways" (verse 3)
The "Glory land Way" that the Psalmist so eloquently describes in these eight verses is very vividly seen in:
I. The Gloryland Way Is The Holy Way (verses 1-3)
A) One Of Cleansing (verse 1)
1. By Our Privilege ("blessed")
The implication asse ...
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Pirpahar hill is located three miles away from Munger in the easernt direction. From the hilltop a beautiful view of the city can be enjoyed. The hill is associated with deep religious beliefs as this has been named after a Mohammedan saint whose name is unknown but devotees do come up to worship at his grave.
There are two tombs at the foothill one of which is in the memory of a lady named Mary Anne Beckettand the other is of a person called D'Oyly. There is no clarity on the tombs, nevertheless, they add to the attraction and mystery of the entire location.
Tell us what do you think of Mahendragarh
Travel Talk
- Will Suggest 100
- My Favourite 56
- Been There 54
- Will Plan 52
- Will Avoid 21


text:
Disaster Aid in Nepal
Disaster Aid response Teams have been busy bringing emergency supplies to earthquake-ravaged Nepal.
Disaster Aid response Teams have been busy bringing emergency supplies to earthquake-ravaged Nepal.
Our team of volunteers in Vanuatu has now distributed a number of home repair kits, which were purchased locally to boost the local economy. When Cyclone Pam hit some weeks ago, many lost all their possessions and belongings - houses, fishing boats, clothing. Rebuilding after a major disaster is very difficult, even for a population as resilient as that of Vanuatu.
We have now distributed individual water filters and home repair kits. Yet the needs are still great. Over the coming weeks we will keep working with the people of Vanuatu to assist with their challenge in having access to clean water. In Vanuatu under half of the rural population has access to safe drinking water.
Help us make a different for the people of Vanuatu by donating for this cause. Long after the images of the cyclone stop making the news, we will continue to work with this population to find sustainable solutions to the challenges they face.
Disaster Aid Australia DART Response Teams, already working in the Philippines after the devastating earthquake on Bohol island, are in Leyte today with the Balay Mindanaw team to perform assessments and assist the sourcing and effective delivery of aid working alongside local government authorities.
Team Leader Ed Cox who was deployed to Indonesia after the 2004 Tsunami described the devastation on Leyte as, "far greater than what I witnessed in my 10 years as an aid worker. I was in Bandah Aceh, Indonesia in 2004, what I have seen today is far worse than that, almost every home has been destroyed and thousands are missing: families are absolutely devastated.
"Everything that Disaster Aid Australia has in its warehouse will be sent to the Philippines. This disaster will need more ... and then more "
Disaster Aid Australia's work continues in the Philippinesas we help communities rebuild.
SkyHydrant™ water filtration systems are being installed on Panay Island working with the RC of Metro Iloilo and on Mindanao Island working with local Rotary Clubs and Balay Mindanaw
giving communities clean drinking water.
Disaster Aid International (Australia) has deployed DARTs (Disaster Aid Response Team members) Dianne Holland (Australia) and Wayne Beaumier(USA) to Vanuatu. They arrived on Thursday 26 March. Their initial assessment – working within the communities, and with other aid organisations – confirmed the priority was for clean, safe water. That is confirmed in reports by the UN agency OCHA: "110,000 need clean safe drinking water".


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|Specific References
|Related Products
|A DNA sequence encoding the human LSAMP (Q13449) (Met 1-Asn 315), without the pro peptide, was expressed, with a polyhistidine tag at the C-terminus.
|Human Cells
|In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
|> 97 % as determined by SDS-PAGE
|< 1.0 EU per μg of the protein as determined by the LAL method
|Samples are stable for up to twelve months from date of receipt at -70℃
|Val 29
|The secreted mature form of recombinant human LSAMP consists of 298 amino acids and has a predicted molecular mass of 33.4 kDa. As a result of glycosylation, the apparent molecular mass of rhLSAMP is approximately 45-55 kDa in SDS-PAGE under reducing conditions.
|Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
|Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.
|Product name
|Product name