text:
Sulfotransferase 1A1 (
Sulfotransferase 1A1 (
Transcription Factor Activation Profiling Plate Array assay was used to identify the possible transcription factors that regulate the gene expression of
In normal human liver samples, SULT1A1 mRNA level was positively associated with NFI-C. In different human breast cancer and normal epithelial cell lines, SULT1A1 expression was positively correlated with NFI-B and NFI-C. SULT1A1 expression was decreased 41% and 61% in ZR-75-1 cells treated with siRNAs against NFI-A and NFI-C respectively. SULT1A1 gene expression was higher in cells containing more than one
Our data suggests that SULT1A1 expression is regulated by NFI, as well as
Treatment of estrogen receptor- (ER-) positive breast cancer with tamoxifen (TAM) has been the gold standard for the past 30 years
Sulfotransferases catalyze the transfer of a sulfonate group from 3′-phosphoadenosine 5′ -phosphosulfate (PAPS) to a range of xenobiotic and endogenous compounds such as drugs, carcinogens, and steroid hormones
Some studies have shown that single nucleotide polymorphisms (SNPs) in the human
Cell culture
The human breast cancer cell lines ZR-75-1, MCF-7, T-47D, MDA-MB-231, and the human transformed mammary epithelial cell line MCF-10A were purchased from American Type Culture Collection (Rockville, MD) and were sustained in a 37°C incubator containing 5% CO2. ZR-75-1 cells were cultured in RPMI 1640 medium with 10% fetal bovine serum (FBS). MCF-7 cells were cultured in Improved MEM medium with 10% FBS and 0.01 mg/ml insulin (Life Technologies, Carlsbad, CA). MDA-MB-231 cells were cultured in DMEM medium with 10% FBS. MCF-10A cells were cultured in DMEM/F12 medium supplemented with 5% chelex-treated horse serum (Life Technologies), 20 mg/ml of epidermal growth factor (Life Technologies), 10 μg/ml insulin (Sigma, St. Louis, MO), 0.5 g/ml hydrocortisone (Sigma), and 0.1 μg/ml cholera toxin (Sigma).
Human subjects
Normal human liver samples (n = 84) were obtained from the U.S. Cooperative Human Tissue Network under a University of Arkansas for Medical Sciences Institutional Research Committee-approved protocol. All specimens were snap-frozen upon collection. Normal tissue status was confirmed with histology by the Cooperative Human Tissue Network. Samples included 33 women and 51 men, all of whom were Caucasian. The average age of the study population was 59, ranging from 26 to 102.
Differential transcription factor activation assay
The differential TF activation profile in ZR-75-1 and MCF-10A cells was determined using a TF Activation Profiling Plate Array assay following the manufacturer's instructions (Signosis, Sunnyvale, CA). Briefly, 5 μg of nuclear extract from ZR-75-1 or MCF-10A cells was hybridized with 48 different biotin-labeled probes that contain consensus sequences of TF DNA-binding sites. The TF-bound probes were captured by complementary sequences of the probes pre-coated on a 96-well plate. The captured probes were detected with streptavidin-HRP. The levels of luminescence of each corresponding well were quantitatively analyzed with Spectramax M5 (Sunnyvale, CA) and compared between MCF-10A cells and ZR-75-1 cells.
Nuclear factor I (NF-I) siRNA treatment of ZR-75-1 cells
All siRNAs and transfection reagents were purchased from Life Technologies. ZR-75-1 cells that were at the exponential growth stage were transfected with 50 pmol of pre-designed siRNA against 4 NFI family members (NFI-A, NFI-B, NFI-C, NFI-X) or 100pmol siGAPDH as a negative control using Lipofectamine™ 2000 transfection reagent following the manufacturer's instructions. After 48 h transfection, cells were collected for total RNA isolation. The percentage of knockdown of target gene expression was determined using quantitative RT-PCR (qRT-PCR). The sequences of siRNAs are listed in Table
DNA and RNA isolation and quantitative real-time PCR (qRT-PCR)
Total RNA and total DNA from cultured cells and from snap-frozen human liver tissues were isolated with an AllPrep® DNA/RNA/protein kit (QIAGEN, Valencia, CA) according to the manufacturer's instructions. The quantity and quality of the isolated RNA and DNA were determined by an Agilent 2100 Bioanalyzer (Agilent Technology, Palo Alto, CA). qRT-PCR using SYBR-green reagent was performed and analyzed as described previously
Determination of
Statistical analysis
SULT1A1 Expression levels in different breast cancer cell lines
Other laboratories have reported that expression of SULT1A1 is very low in normal breast tissue as compared to tumor tissue
Figure 1
SULT1A1 mRNA levels in different cell lines
SULT1A1 mRNA levels in different cell lines. Total RNA was isolated from cells that were cultured at exponential growth stage. The mRNA levels of SULT1A1 in ZR-75-1, MCF-7, T-47D, MCF-10A, and MDA-MB-231 were determined by real-time RT-PCR and were normalized with 18S.
Correlation of gene expressions between NFI family genes and SULT1A1
One possible mechanism of differential SULT1A1 expression in different cell lines could be the availability of TFs. To test this hypothesis, the TF Activation Profiling Plate Array assay was performed in normal breast MCF-10A cells and breast cancer ZR-75-1 cells. TF activation profile differences in MCF-10A cells and ZR-75-1 cells were quantitatively analyzed and compared as described in Methods. Out of 48 TFs, 13 had at least 1.5 fold more DNA-binding activity in ZR-75-1 cells compared to MCF-10A cells (data not shown, see Additional file
Additional file 1
Differential transcription factor activities levels between MCF-10A and ZR-75-1 cells. Transcription factor activation profile was determined using a TF Activation Profiling Plate Array as described in Methods. Data chosen from results showing that transcription factor activation level in ZR-75-1 cells (black bar) was at least 1.5 fold higher than that in MCF-10A cells (gray bar).
Click here for file
Figure 2
Correlation between SULT1A1 mRNA and NFI-C mRNA in Human liver
Correlation between SULT1A1 mRNA and NFI-C mRNA in Human liver. SULT1A1 mRNA level was highly correlated with NFI-C mRNA level (r = 0.64, p < 0.0001). Real-time RT-PCR was performed in liver samples taken from 84 healthy subjects as described in Methods. Data was normalized with 18S.
Additional file 2
Correlation between GATA-1 mRNA and NFI-C mRNA in Human liver. Real-time RT-PCR was performed in liver samples taken from healthy subjects as described in Methods. Data was normalized with 18S. GATA-1 mRNA level was not correlated with SULT1A1 mRNA level (r = 0.17, p = 0.11).
Click here for file
Next, gene expression correlations between SULT1A1 and all four individual NFI family genes in different cell lines were explored. mRNA levels of NFI-A, NFI-B, NFI-C, NFI-X, and SULT1A1 in MCF-10A, ZR-75-1, T-47D, MCF-7, and MDA-MB-231 were determined by qRT-PCR and normalized with 18S mRNA. SULT1A1 gene expression was highest in ZR-75-1 and T-47D cells, as were NFI-B and NFI-C gene expression (Table
Regulation of SULT1A1 gene expression by NFI family genes
To determine if any of the four NFI genes has an effect on SULT1A1 gene expression, ZR-75-1 cells, which have the highest SULT1A1 gene expression in this study, were transfected with siRNAs that were directed against NFI-A, NFI-B, NIF-C, or NFI-X for 48 h as described in Methods. The mRNA levels were determined by relative RT-PCR, and the 2-ΔΔCT method was used
Figure 3
Effects of NFI siRNAs on SULT1A1 mRNA gene expression
Effects of NFI siRNAs on SULT1A1 mRNA gene expression. ZR-75-1 cells were treated with siRNA against NFI mRNAs as described in Methods. Total RNA was extracted for gene expression analysis 48 h later (n = 3 for each mRNA expression level). Data was normalized with 18S. *
Additional file 3
Screening of SULT1A1 gene expression activators from MCF-7 cells treated with siRNAs. SULT1A1 mRNA levels were determined with The Expressed Transcription Factor Knockdown Transcriptome PCR Array (Qiagen, Valencia, CA) following the manufacturer's instructions. Briefly, real-time PCR was performed with cDNAs derived from MCF-7 cells treated with siRNAs targeting 270 transcription factors. SULT1A1 gene expression levels were expressed as Log2 fold changes based on Ct calculation using 18S as house-keeping gene and non-target siRNA treated sample well (VTC) as negative control. The arrow indicates SULT1A1 gene expression was decreased more than four-fold in siNFI-B transfected MCF-7 cells.
Click here for file
To test whether different NFI TFs had an additive effect on regulating SULT1A1 expression, ZR-75-1 cells were also co-transfected with siNFI-A, siNFI-B, and siNFI-C for 48 h. As shown in Figure
Relationship of SULT1A1 gene expression with its gene copy number
Previous reports demonstrate that individual DNA contains one to five copies of the SULT1A1 gene
To test if copy numbers correlate with SULT1A1 gene expression level, the amount of mRNA of SULT1A1 and corresponding
SULT1A1 is expressed in different tissues, in different physiological states of the same tissue, and in different individuals. The factors that regulate SULT1A1 gene expression are poorly understood. Human studies show that SULT1A1 can be regulated by alternative promoter usage
The data presented here suggest that NFI may play a major role in regulating SULT1A1 expression in different physiological and disease states. The NFI family proteins are associated with changes in different cell growth states and with oncogenic processes and disease states as reviewed in
NFI siRNA knockdown experiments inhibited about 40% of SULT1A1 expression in ZR-75-1 cells, suggesting other regulatory mechanism(s) exist. Previous studies have shown that the human population possesses one to five copies of
In summary, our data demonstrate that the NFI family of transcription factors significantly contributes to the regulation of SULT1A1 expression in human breast cancer cell lines. Along with these TFs,
Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
SULT1A1: Sulfotransferase 1A; NFI: Nuclear factor I; ESR1: Estrogen receptor α; UTR: Untranslated region; CNV: Copy number variant; UGT: Uridine diphosphate glucuronosyltransferase; PAPS: 3′-phosphoadenosine 5′ –phosphosulfate.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
SAK and AY-B participated in the study design. AY-B, LJR, RBP, XY, VKE, and SW carried out data collection. AY-B, RJP, VKE, IBD, SAK contributed in data analysis and interpretation. SAK, AY-B, RBP, and VKE were involved in manuscript preparation. All authors have read and approved the final manuscript.
This is worked have been supported by 1R01CA128897 (NCI to SAK).
Trends in use of adjuvant multi-agent chemotherapy and tamoxifen for breast cancer in the United States: 1975–1999
Tamoxifen for early breast cancer: an overview of the randomised trials. Early breast cancer Trialists' collaborative group
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials
Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases
Enzymology of human cytosolic sulfotransferases
Human platelet phenol sulfotransferase: partial purification and detection of two forms of the enzyme
Identification of two human brain aryl sulfotransferase cDNAs
Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry
Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy
Expression profiling of human sulfotransferase and sulfatase gene superfamilies in epithelial tissues and cultured cells
Differential expression of sulfotransferase enzymes involved in thyroid hormone metabolism during human placental development
Human platelet phenol sulfotransferase: familial variation in thermal stability of the TS form
Functional genetic variants in the 3′-untranslated region of sulfotransferase isoform 1A1 (SULT1A1) and their effect on enzymatic activity
Sulfation of 4-hydroxy toremifene: individual variability, isoform specificity, and contribution to toremifene pharmacogenomics
Very important pharmacogene summary: sulfotransferase 1A1
Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?
Sulfation and sulfotransferases 4: bioactivation of mutagens via sulfation
Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk
Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility
Sulfonation in chemical carcinogenesis–history and present status
Estrogen sulfotransferases in breast and endometrial cancers
Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines
Common genetic polymorphisms in the 5′-flanking region of the SULT1A1 gene: haplotypes and their association with platelet enzymatic activity
Relationship of phenol sulfotransferase activity (SULT1A1) genotype to sulfotransferase phenotype in platelet cytosol
Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype
Human SULT1A1 gene: copy number differences and functional implications
Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1
The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein
Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
Human phenol sulfotransferase gene contains two alternative promoters: structure and expression of the gene
Roles of the NFI/CTF gene family in transcription and development
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
The Nuclear Factor I (NFI) gene family in mammary gland development and function
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
UFC fans unite and meet up to watch UFC 214 at The Independent Sports Bar & Grill on Saturday, July 29th for Jon Jones v Daniel Cormier.
Tag Archives | The Independent portland
2017 Kentucky Derby Party @ Downtown Portland's The Independent | Free, Mint Juleps, Hot Brown, Fancy Hats, Best Dressed Contest
Join us on May 6th for "The Greatest Two Minutes in Sports" aka the Kentucky Derby at the Independent Sports Bar & Grill! The race starts at 3:30pm PST.
2017 Portland March Madness Indy's Wild Chase Bracket Contest | Early Bird Menu, $5 Bloody Marys, Giveaways, Viewing Parties & More!
March 16-19 @ The Independent – Watch the action at our viewing parties, March 16th, 17th,18th & 19th, open at 8:30am, where we'll be serving early bird menus & $5 Bloody Mary's. Get our tournament special, $5 Jim Beam Black at every game.
Watch UFC 208: Holm vs. De Randamie in Downtown Portland @ The Independent | Massive Drop Down Projector, 32 Screens, 20 Taps
February 11 @ The Independent -UFC fans unite and meet up at The Independent Sports Bar & Grill on Saturday, Feb 11th for Holm vs de Randamie.
MANY Portland Weekend Events & Giveaways ($1,200+): Super Bowl, Winter Light Festival, Valentine's Day Events & Ideas, Escape Rooms & more! | February 2-5, 2017
Hello Portland! Super Bowl weekend is here, see our roundup of great places to catch the game! Stay warm w/ Urban Tellers or A Golden Age of Poster Design. The Winter Light Festival returns to OMSI or see BYTE ME! 6.0's interactive exhibits. Lan Su Chinese Garden's Chinese New Year celebration continues this weekend! And […]
Many 2017 Portland Super Bowl Watch Parties | Food & Drink Specials, HUGE Screens, New England Patriots vs Atlanta Falcons
February 5 – And then there were 2! This Sunday, the Atlanta Falcons battle the New England Patriots in the 51st Super Bowl! There's plenty of great places to watch the game in Portland!
Watch 2017 Super Bowl in Downtown Portland @ The Independent | New England Patriots vs Atlanta Falcons, 20+ Taps, Multiple Screens, Projector, Bottomless Tacos, Raffle & more!
February 5 @ The Independent – Join us at The Independent Sports Bar & Grill for a Football Fiesta and the 51st Superbowl – New England Patriots vs. Atlanta Falcons.

subset: commoncrawl


text:
This antique fraternity badge features a won black enamel center featuring the Greek letters Alpha Delta Sigma. The enamel is framed in yellow gold and the frame is decorated with seed pearls and four genuine garnets. The clasp on the back of the badge dates the badge c. 1890s. The back is engraved JMAR.
This badge measures 13/16" (20.4mm) tall, 7/16" (11.3mm) wide and weighs 2.1 grams.
We guarantee this piece to be 14k gold as tested. It has not been cleaned in order to maintain it's original vintage integrity. Please check out the enlarged pictures.
2 other shoppers have this item in their Cart or Wish List .
Estate & Vintage Jewelry
|Shipping & Handling:
USPS First-Class Mail Parcel
|Shipping to:
|other services


text:
Free Shipping $50+ within Continental US
- Pre-Order Item: Estimated Shipment Date: July 2017
- It's Dark Ninja from Ninja Slayer From Animation!
- Includes various hand parts, alternate head part, 'Beppin' sword, figure stand, and more
- Made of ABS and PVC. Japanese import.
- Product dimensions: 150mm
- Qualifies for FREE SHIPPING


text:
I found this primer article that mentions radio options you should consider for grid-down events. If you don't have your HAM Radio license yet, I strongly urge you to find a nearby class & get it. It's so simple to get started…you get to study the pool of possible questions & you'll know the correct answer ahead of time. It's memorization!
I'm hoping to get my General class later this year. Find a class near you HERE.
Click on the image below or Click HERE to visit today's DIY.


text:
Savannah Allison
Savannah Allison (August 21 1990)
» Click to list general statistics » OR, select a date :
Dark Angel
I am a dark angel,
I am one of Gods children,
but I have my sins,
read more >>
- Hits: Number of visitors who read the poem on the given date.
- Posts: Number of visitors who posted the poem to a friend (via e-mail) on the given date.
- Dates that have "0" hits may not be shown on the list.
- Dates, poems and poets that have "0" hits may not be shown on the list. Statistics are generated daily.


text:
Lippen-Bekenntnisse Eines TeenagersFavorites [+]
Pay-Per-Minute Viewing
You can now enjoy this movie on your iPhone®, iPad®, or compatible Smart TV & Android devices.
Purchase Options
Pay-Per-MinutePurchase Minutes
Streaming Rentals
Available MP4 sizes:SD 480p (1.29 GB)
DRM-free downloads offer content that is not limited by standard Digital Rights Management (DRM) access technologies. These technologies allow hardware manufacturers, publishers, copyright holders and individuals to limit the usage of digital content.
When you purchase DRM-free downloadable content, that content is available for you to download on any computer and save to a disk whenever you like. You can also download to multiple computers. There is no timeframe associated with your purchase and the content will not expire.
Running Time: 83 minutes
Released: 06/2006
Studio Name: Videorama
Director: Ben Franklin
Categories: Euro Feature Natural Breasts Teen International German Speaking
Description: Leonie has a new apartment and Daddy pays her rent. It could not get any better for her. Also her friends are excited because now they can let their lust become reality. Very quickly does the apartment turn into a den of fucking.
5 Scenes from Lippen-Bekenntnisse Eines Teenagers
Lippen-Bekenntnisse Eines Teenagers: Scene 1 Free Preview
Sex Acts: Vaginal Sex, Oral Sex
Positions: Doggy Style, Cowgirl, Spoons position, Reverse Cowgirl, Laying, Missionary, Standing
Settings: Bedroom
Lippen-Bekenntnisse Eines Teenagers: Scene 2 Free Preview
Sex Acts: Toy Play - Vaginal, Toy Play - Oral, Masturbation, Oral Sex, Vaginal Sex
Settings: Porn Shop
Lippen-Bekenntnisse Eines Teenagers: Scene 3 Free Preview
Sex Acts: Oral Sex, 3-Way, Fingercuffing - Vaginal
Positions: Doggy Style, Cowgirl, Reverse Cowgirl, Sitting, Side Saddle, Standing Doggy Style, Laying, Missionary, Standing
Settings: Living Room
Lippen-Bekenntnisse Eines Teenagers: Scene 4 Free Preview
Lippen-Bekenntnisse Eines Teenagers: Scene 5 Free Preview
Sex Acts: Anal Sex, GangBang, Vaginal Sex, Oral Sex, Fingercuffing - Double Vaginal, Fondling, Fingercuffing - Vaginal, Double Penetration
Positions: Cowgirl, Standing Missionary, Reverse Cowgirl, Standing Cowgirl, Doggy Style, Sitting, Side Saddle, Standing Side Saddle, Laying, Standing
Settings: Rooftop, Living Room
Recommended Movies
AEBN Cams


text:
Download Right Brain Flashcards (Lite) apk 1.16 free for Android smartphone
Posted by Alvis Software in Education | July 15, 2016 | 6 Comments
Apk file size: 7.7 MB
This flashcards app contains Colours, Shapes, Fruits, Vegetables, Flowers, Animals, Transportation, Insects, Stationery and Tools.
The bridges for right brain training (右脑训练) are Love and Speed.
Right brain training is only effective if the child is living in a loving environment. This is because any right brain training works best when the child is happy. When the child relaxes, the left brain relaxes too, and thus the right brain will take over. When the child is stressed, unhappy or crying, the right brain will shut off.
Showing flashcards at a fast rate helps to open up the right brain. Data is presented quickly such that the left brain cannot keep up and eventually gives up which gives the right brain a chance to handle it. Showing cards slowly and explaining one by one is a left brain training method.
2 of the unique right brain functions are Photographic Memory and High-capacity Memory. By flashing cards, you show pictures and say words at the same time. As a result, you connect both brains. Pictures and images are processed by the right brain, while language and words are processed by the left brain.
Flashcards also expose the child to a wider range of vocabulary.
* Affordable - FREE as compare to the flashcards sold in bookshops.
* Portable - It can be installed in mobile phones or tablets which can be used anytime, anywhere.
* No Learning Curve - Parent does not need to learn the technique of flashing cards.
* Simple but Effective.
* Able to select the voice (accent).
* Able to select 2 different modes of quiz.
* Able to choose the speed of flashing the cards.
* Able to choose the flashing iterations.
First, select the Flashing mode in the Settings page.
Show every category to the baby/toddler using that mode. Whenever possible, try not to let them touch the phone during the flashing. For a baby/toddler, when they are not allowed to touch something, their interest will be greater and their focus can be longer.
After about one to two weeks, switch to the Quiz (Picture) mode. Let them choose the correct picture after a word is being spoken.
Then, change to the Quiz (Word) mode. Let then choose the correct word after a picture is shown and spoken.
Always remember to encourage them whenever they choose the correct answer by applauding them or giving them a hug.
Please send me your experience on using this application via email (email@example.com) or posting it on Right Brain Flashcards Facebook Group (https://www.facebook.com/groups/411116319058920).
Whats new
* Adjust the speed of the speech to be in sync with the flashing speed setting.
* Added Facebook Group and Rate Me buttons.
* Minor UI touchup.
* Added a score feature for Assessment mode.
Alvis Software part of our Education and have average installs from 100 to 500. Last Update July 15, 2016. Google play rating is 100.0. Current verison is 1.16. Actual size 7.7 MB.
Similar applications
Mental Calculation FLASH ANZAN229 Comments
6 Comments
fatt q
Great app for the young one! Very easy to use and intuitive! An effective educational app for the young one!
Siguo Chaa
Great App! Suggest to pop up error when wrong item is selected during assessment mode.
cefellowlai cefellowlai
Awesome app for babies!
Dave Low
Simple to use, best for toodlers. Waiting for more categories to be added!
XB Cuber
Best app ever Simple but excellent!
Renu Saharan
Amazing App for the little champions. My baby gonna love it <3. Wish to have an option to add family members photo and let him recognize who he/she is.


text:
With First Tutors: Music you can locate a Bexleyheath mandolin teacher. Mandolin tuition are an excellent method to begin an entertaining new hobby, pick up a new skill and gain confidence in mandolin. Please use our site to search for Bexleyheath mandolin teachers and choose which best suits your requirements so you can start your mandolin lessons in Bexleyheath straight away!
First Tutors: Music is the fastest way to find Bexleyheath mandolin tutors in the UK, helping you discover Bexleyheath mandolin lessons in your area and Bexleyheath tutors to assist with any instrument like piano, violin or guitar. We can help you find Bexleyheath mandolin tuition or a one-to-one Bexleyheath mandolin tutor to prepare for mandolin grades and improve your mandolin skills! Our search will order Bexleyheath mandolin teachers local to you by their tuition charges and distance from you.
If you are a mandolin tutor and would like to offer your mandolin lessons in Bexleyheath or anywhere else across the UK, please register with First Tutors: Music or find out more about us here. Becoming a Bexleyheath mandolin teacher is a fantastic way to improve your own knowledge by providing mandolin lessons while assisting others, all in your local Bexleyheath area!


text:
Power Girl Cosplayer Photo 2 by hunterfanWatch
©2010-2017 hunterfan
Oh God Red Eye! Run! She's using her heat vision! LOL. Ah another Power Girl Cosplay pic. Anyway, who is Power Girl? PG is a DC comics character who came about just before the event comic 'Crisis on Infinite Earths'. She's a Kryptonian from a parallel earth, and is Superman's cousin. Honestly, she's my favorite female superhero. She's funny, energetic, upbeat, feisty (a bit of an anger problem there), emotionally complex, and intelligent. But everyone only seems to know her by two of her attributes (guess which), which is bull as she really is an awesome person.
YES! ...I don't know why I yelled. But cool.
She's got the perfect figure for the role of PG anyway. Nice pose for the camera and her boobs are perfect for the part. Power Girl herself would be impressed
I totally agree on all counts.I'm quite sure Karen would be very flattered.
Very good cosplay here! Very natural.
I know! Such a great job. She won first in the beginners section of the cosplay contest at the con I saw her at.
Ha ha I hadn't even thought of red eye from the camera being the heat vision. I love it
I think the idea of twin heat blasts lancing off the of the photographer gives this photo a certain charm.


text:
|Two Player Gamebook
|Publication details
| Andrew Chapman
& Martin Allen
|John Blanche
|Cover illustrator
|John Blanche
|First published
|August 1 1986
|No Wizard Reprint
The Warrior's Way is a single-player role-playing gamebook written by Andrew Chapman and Martin Allen, illustrated by John Blanche and originally published in 1986 by Puffin Books. It forms part of Steve Jackson and Ian Livingstone's Fighting Fantasy series. It is unnumbered in the original Puffin series (ISBN 0-14-095314-0) and was sold as part of a boxset along with The Warlock's Way. There are currently no announced plans to republish this book as part of the Wizard series.
The Trial of KingshipEdit
" At last - a thrilling TWO-PLAYER Fighting Fantasy Adventure!
YOU are Clovis, Warrior-Prince of the golden city of Gundobad. Your partner plays your twin brother and rival, Lothar, the Warlock-Prince. The time has come for one of you to succeed to the throne of Gundobad, and you must both face the Trial of Kingship.
But beware! The Trial of Kingship is not for the faint-hearted! Many dangers, traps and vile monsters lie in wait for the unwary, but with your sword and your spells, you may win through.
Two dice, a pencil, an eraser - and a friend! - are all you need to embark on this perilous and thrilling adventure. YOU decide - sometimes alone, sometimes with your partner - which dangers to risk and which enemies to fight.[1]
The book in general follows the original rules set down in The Warlock of Firetop Mountain. (see Game System)
Unique RulesEdit
- For information on the attributes action and status see Clash of the Princes
- Provisions only restore 2 stamina points each time.
Equipment ListEdit
No equipment list is given in the "Introduction" bar the provisions, the rest being listed in "The Trial of Kingship".
- Sword
- Horse
- 10 Provisions
- 10 Gold Pieces
Cover and IllustrationsEdit
The original cover of the book was designed and illustrated by John Blanche.
- No listed price as only sold as part of £3.99 boxset
The interior illustrations were by John Blanche. There were 33 full page illustrations and 10 minor repeated illustrations scattered throughout the text (the minor art is identical to the companion book The Warlock's Way). The paragraphs with a full page illustration were (* indicates an illustration identical to that of The Warlock's Way): 1, 12*, 25, 44, 57*, 72, 88*, 99, 117, 134, 149, 166, 179, 191, 210, 224, 235, 250*, 266, 286, 306, 324, 337, 357*, 370, 387, 403, 423, 439, 456, 471, 487 and 499. Additionally, four paragraphs, (49) (74) (227) and (297), each had an additional minor illustration of a puzzle within the body of the paragraph.
The colour map on the inside front cover was by Dave Andrews.
Intertextual ReferencesEdit
Other MediaEdit
Main CharactersEdit
- Antlion
- Arms
- Black Bear
- Boar
- Carnivorous Plant
- Cavemen
- Chad
- Chameleon Man
- Cyclops
- Demon
- Dwarfs - Old/Young
- Gargoyle
- Ghosts
- Ghoul
- Giant Bat
- Giant Flies
- Giant Spider
- Giant Toad
- Gnome
- Gorilla
- Heads
- Hedge
- Humans - Druid/Henchmen/Slave-Trader/Wife/Witch/Woodmen
- Ice Warrior
- Iceworm
- Kobolds
- Leeches
- Lizardmen
- Minotaur
- Moth
- Mr Todd
- Ogres - Bert/Bill
- Orcs
- Reflection (The player fights themselves)
- Rock Giant
- Scuttlies
- Sloth
- Strangler
- Troll
- Vampire
- Werewolves
- Wight
- Wolves
- Wraiths
- Zombies
Further NotesEdit
- Bill and Bert the Ogres have rather bizarrely different stats in the two books – Lothar fights them fighting as one relatively weak individual, but Clovis has to fight both of them separately (and they have stronger stats).
- Many of the instant death references and/or spell failures are remiss in reminding the player to alter the action and status scores to 1.
- (235) refers to possession of an object called the Cat's Eye (presumably a gemstone) that would not appear to occur anywhere else in the adventure.
- (2) gets its options mixed up - it should be turn to (256) to head towards a cluster of low hills, and turn to (140) to wander westwards through a wood.
- (274) features a tinderbox mysteriously becoming part of your equipment when it is lacking from the start.
- The colour map by Dave Andrews is (other than showing two cities called Gundobad and Kalamdar) completely at odds with large sections of the adventure. Tangible features of the adventure's text either do not appear, or are not named, and one thing that is named on the map, Dragon Hove, is not represented in the text. Comments by Andrew Chapman on Demian Katz's Yahoo! gamebook list have indicated there were communication problems between the Australia-based writers and the British publishers at the time.
- (190) says that Clovis you encounters the "dead body of a monstrous three-headed Hydra" which usually is correct. However there is an unlikely event where Lothar's transformation spell misfires, creates a nine-headed Hydra and then manages to kill the beast.
- A similar problem presents itself at (51). If Lothar goes first, creates the nine-headed Hydra then dies, Clovis should meet with that instead of the regular three-headed one.
Thanks to Keith, Gail and Karl
Special thanks to Dennis Moyle
See AlsoEdit
External LinksEdit
- Character Sheet
- Fighting Fantasy at Gamebooks.org
- Clash of the Princes at Gamebooks.org
- The Warrior's Way at Gamebooks.org


text:
Chemical Dessication of Castorbeans in the Southeast1
- Thomas W. Culp2
Chemical desiccation and early harvesting may be a method of producing a profitable crop of castorbeans in areas where diseases destroy the capsules late in the growing season.Please view the pdf by using the Full Text (PDF) link under 'View' to the left.
Copyright © . .


text:
by Kurt Nimmo, Infowars:
South Carolina Gov. Nikki Haley received a handgun from her husband this Christmas. On the lib blogosphere and news sites, though, this is considered somehow news worthy.
Millions of Americans have received firearms as Christmas gifts present and past. We should all be thankful that, more or less, that part of the Bill of Rights still works. For now. On social media some of the libs went bonkers. "I will say a prayer for your family" read one message, insinuating that the families of gun owners are at risk when the Second Amendment is practiced.
Democrats believe simply owning a handgun is some kind of political tactic. "Everything is about politics with her. Everything," state Democratic party director Amanda Loveday tweeted, according to The State.
Please follow SGT Report on Twitter & help share the message.


text:
5 Things You Need to Click - 3.7.14
At 41, CARMEN ELECTRA is now the oldest "FHM" cover girl
A high school teacher in California made a video asking WILL FERRELL to co-chaperone the prom with him.
A trailer for the new "Sin City" movie, "Sin City: A Dame to Kill For"
An article about movie projects that never saw the light of day at Disney includes "Where the Wild Things Are" and a "Who Framed Roger Rabbit" sequel or prequel.
QUEEN is going on tour this year with ADAM LAMBERT on vocals. They released some tour dates yesterday.


text:
Carlos Banegaski Photographer
YukiNoHanaModel Female Tampa, Florida, US
Mayhem # 3108309
About MeFor more information about me, message me!
I would like to acquire some from professional experiences. I've been interested in the modeling industry since I was younger, but I won't know for sure if it's for me until I try it. Any interests to help me reach this goal, educate me, and/or even giving me any type of related opportunity/experience, please contact me.
Thanks ^_^
Have you worked with YukiNoHana? Add Credits for YukiNoHana! >>
Carlos Banegaski Photographer
Taichi Hatano Retoucher
Joseph Moran Photographer
jamesj95 Photographer
Dana Clausing Photographer
Dan Sanderson Model
Loading Content


text:
Air Conditioning and Refrigeration Engineer
- Recruiter
- Astra Recruitment
- Location
- Plymouth
- Salary
- £15 per hour + Overtime
- Posted
- 05 May 2017
- Expires
- 13 May 2017
- Sector
- Engineering
Title: Refrigeration & Air Conditioning Engineer Location: Plymouth/East Cornwall Salary: £15 Hour Overtime & Standby Allowance We have got a great opportunity for any experienced Refrigeration Service Engineer who is able to travel across Plymouth and East Cornwall to carry out engineering tasks. You will be working for a well-established company with a great reputation and strong presence within the area; with this comes great stability and rewards for the successful candidate. Realistic earnings in excess of £40,000 for an engineer that possesses the right attitude and skillset. You Will Need: - Confident in all aspects of Commercial Refrigeration and Air Conditioning. - Strong electrical knowledge as well as F-Gas qualification. - Minimum of five years' experience in a similar Refrigeration Engineering role. - Proven installation experience with an Engineering services SKILLcard. - A drive for providing quality workmanship. - Reside within a 15-mile radius of the Plymouth area. - A full driving license. - The ability to be part of a standby rota (one week in five). If you would like to learn more about this role then please contact our dedicated Engineering consultant, Aimee Thompson. /


text:
From his debut album 'Lucky Shiner', Gold Panda's 'Marriage' has got to be one of the most 'feels' inducing tracks ever.
This elegant instrumental from the British producer was the first taste of Gold Panda's music for my 16-year-old self, which - coming from a kid in grade 10 - came about at the perfect time of my life.
The familiar loop is one that just sticks to your brain, with its uplifting synth work and choppy, unorthodox beat-making textures that helped kick off a more experimental approach to dance music that followed. If this song was released tomorrow and not 6 years ago it would be still be just as great. Mark my words on that one.
Listen to Gold Panda's 'Marriage' below and let it soak in.


text:
You have no items to compare.
Product Description
Many Hollywood starlets with picture perfect bodies, women who look toned and sexy even after giving birth, body builders with chiselled six packs, and some of the fittest men on the planet have probably answered yes to at least one of these questions at some point too! If you're like them, you probably hit the gym frequently, watch what you eat, and incorporate exercises designed to specifically target the ab area into your workouts. But what if all this simply isn't enough? Maybe you're not getting the definition you want in the abdominal area, or perhaps nothing seems to remove that pesky outer layer of fat so you can show off the muscle underneath. If this describes your situation you don't have to give up on getting the flawless abs you see at the gym, in magazines, and on television! You probably just need a little help.
LA CUTS has the fat-melting, energy-boosting, hunger-reducing ingredients you need to help you look your best. The science behind LA CUTS is different from other (often ineffective) diet pills on the market and natural diet supplements with ingredients that do very little to help users shed and burn fat. Why? Because LA CUTS is capable of promoting thermogenesis, a word everyone interested in losing excess fat should know.
Thermogenesis occurs when there is a boost in body temperature. This in turn increases the energy demands on the body. Most people have a huge energy reserve in their fat cells…which is precisely what is consumed during thermogenesis. For that reason, the terms fat burning and thermogenesis are often used interchangeably. Exercise can promote thermogenesis, and so can certain foods. But there are also supplements that, thanks to the ingredients they contain, can stimulate this unique process within the body to help individuals shed fat in the abdominal region and other problem areas. LA CUTS is one of these products. It contains several thermogenic substances and others designed to help with weight loss efforts to help users achieve astounding results.
Additional Information
|Serving Size:
|1 Capsule
|Per Container:
|60 Capsules
|As a dietary supplement, take one serving (1 capsule) 30 minutes before breakfast and 1 serving (1 capsule) in the afternoon. Do not exceed 2 capsules under any circumstances in one day, due to the extreme potency of this product. First time users should assess their individual tolerance before using a full dose or 2 capsules. For best results, use as part of a low fat diet.
|Do not use this product if you are pregnant or nursing, or have been treated for or diagnosed with high blood pressure, heart, liver, thyroid, or psychiatric diseases, diabetes, anemia, nervousness, anxiety, depression, seizure, disorder, stroke, or difficulty urinating due to prostate enlargement. Consult your physician if you are talking an MAO inhibitor or any other prescription drugs. Discontinue or consult your health care professional if sleepiness, tremors, dizziness, nervousness, headache, heart palpitations, or tingling sensations occur. Not intended for use by persons under the age of 18. Improper use of this product may be hazardous to a person's health.
NOTE:Guarana and its extract contain caffeine.
You may also be interested in the following product(s)
Fusion Bodybuilding SUB-Q - Get Beyond Ripped
Regular Price: $56.86
Special Price: $46.75As low as: $41.70
NOW GABA 750 mg - 100 Vcaps
Regular Price: $21.47
Special Price: $14.52As low as: $11.36


text:
This is the auto-expanding/contracting hose that earned The Best rating from the Hammacher Schlemmer Institute because it contracted faster, was the easiest to use, and was the most durable. Using water pressure to automatically expand and contract to 65% the size of a typical hose for convenient storage, The Best model's winning durable construction includes a multi-layered 3/4" tubular latex inner-diameter hose that generates robust water flow and an outer covering made from strong nylon webbing that endured being dragged over asphalt, rocks, and cement garden borders repeatedly without tearing. The Best model's patented design includes solid brass fittings and an integrated valve.
Shipping charges noted in parentheses apply in addition to our standard shipping & service.
We're sorry, but gift wrap is not available. Please call 1-800-395-7006 for Premium or Express delivery rates.
Oversized items scheduled for expedited delivery (Premium or Express) may incur additional shipping and services charges because of their unusual size. Please call 1-800-321-1484 for an estimate of S&S charges. International callers, please call 1-513-860-3397.
We're sorry, but gift wrap is not available for oversized items.
Shipped via truck and may require customer assistance upon delivery. You will be contacted to make an appointment for delivery.
We're sorry, but gift wrap and gift cards are not available.
GST still applies and will be charged upon processing. For complete shipping & service charges please call Customer Service at 1-800-321-1484.
May we recommend:
(based on 27 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Reviewed by 27 customers
Displaying reviews 1-10
Back to top
Previous Page | Next Page »
Best ever hose.
By Rossie
from undisclosed
I ordered a second hose because I liked the first one some much, but I needed a longer hose. I love it. It is easy to use and lighweight. Definitely would recommend these hoses.
Was this review helpful? Yes / No
- flag this review
not as prommised
By Fred
seems to be of good quality but time with wear will only decide.very disappointed does not extend to 50' as advertised. More like 35'
Hammacher Schlemmer Response: The hose will expand with water pressure but if you would like to exchange for a longer one, please contact us at 1-800-321-1484.
Just like all the others
By Disappointed
from Prescott, AZ
The connection to the hose bib leaks.
Bottom Line No, I would not recommend this to a friend
This hose is awesome.
By Fritz
from Washington state
Today I got to use the hose. It worth every penny. It didn't leak. With my disability I can't get around well I was able to water the entire front from one spot. I am so happy I got this company's.Thank you, FritzVancouver Washington
Bottom Line Yes, I would recommend this to a friend
I am not so certain
By Builderman
from Butler, TN
Not the best hose and not the worst hose. True, it takes less space and is light. I am not at all certain it can stand up to farm work but we will give it a try! Believe a commercial hose is best for my use--strong, sturdy, and yes, it will take up more space!
Finnally one that works.
By Paul
from N.Carolina
I have tried several of these type of hoses and they last about a week before breaking. This hose is expensive but you get what you pay for . Well built with brass fittings and strong enough to withstand wear.
Would purchase another one.
By Golf N Gal
from Norman, OK
I bought two 50 ft hoses. I use one in the front that I bought last year from Hammacher! I connected the two new hoses together for another part of the yard. They are great, so far. They are light weight but seem sturdy. The connectors are good quality. You'll know the difference. I don't treat them roughly, but don't baby them either. I had two cheaper pocket hose year before last and they blew before the summer really got started. I use the hose to water my beds, my flower pots, and am using them twice a day to keep the newly sodded fescue wet. We have a sprinkler system, but a hose is needed to pull around to different areas. I haven't washed the car yet, but may try it sometime.
Would buy again
By Keyzcat
from Key Largo FL
About Me Midrange Shopper
Water garden and car.
So far so good
By MZ
from Sylmar, CA
About Me Budget Shopper
The product is light weight and mush easier to use than a traditional hose. You can also control the amount and stream pattern of water well enough (though not as well as a traditional hose). I started using it 2-3 months after receiving it and so I have used it for only a couple of months or so; as a result I can't comment on durability yet. The downside is that there is a lot of splash and water loss at the attachment point to the yard water faucet and it can't be fixed (the spalsh and water loss happens at every closing after each use). I have controlled the splash by attaching the top end of a water bottle to the faucet and I gather the splashed out water in a bucket that sits at the bottom of the faucet (then I empty the bucket little by little with a small container since I can't lift anything heavy). Despite this downside I prefer the hose to a traditional one. I just hope that it lasts a long time.
By Blevin27
from San Francisco
To wash my car.
COPYRIGHT © 2016 HAMMACHER SCHLEMMER & COMPANY, INC. ALL RIGHTS RESERVED. W107147 E. 57th ST • NEW YORK, NY • 10022 • 1-800-_321-1484


text:
by kg4muc
on 9/14/2012
Quality of these resistors are excellent as always! I have been purchasing parts from MCM for several years now albeit with different employers, and have always been satisfied totally !
Great quality component ! Perfect for OEM or service replacement, and price is very competitive as well !
21-1045 - Rosin Core Solder 60/40 Tin/Lead 6OZ.
Rosin Core Solder(six ounces)
Ideal for general purpose electronic repair and assembly use. Tin/lead formulation provides the lowest possible melting point.
21-1046 - Lead Free Rosin Core Solder - Tin / Copper - 6OZ.
Lead–Free Solder
Ideal for general purpose electronic repair and assembly use. Tin/copper formulation meets current requirements for lead free solder use.
30-2485 - Complete Outdoor 40 Mile HDTV Antenna Kit - UHF/VHF
Complete UHF/VHF Antenna Kit
Complete HDTV antenna kit contains everything you need for connecting and installing the provided antenna.
Click Here to see our expanded line of Stellar Labs Outdoor Antennas.
440-10 - NTE2W010 Resistor 10 Ohm 2W Metal
RESISTOR 10 OHM 2W METAL NTE2W010 NTE 2 Watt Flameproof Resistors, Resistance: 10 ohm, Type: Metal Oxide Film, Tolerance: 2 %, Quantity: Sold individually
MCM is our low cost, high product value source. Same quality as the more expensive vendors, without the "expensive." Always fast and dependable.


text:
If logging miles on a treadmill sounds like torture and you consider the great outdoors your training ground...you just might be a cross-country runner. Enter: the latest edition of the PUMA Haraka XC Cross Country Spikes. Built with a sock-like fit and all the protection and stability you need to navigate even the toughest conditions, it's the perfect running buddy. Plus bold colors and a fractured-print graphic because, well...why not?
- Mesh upper for breathability with synthetic overlays for support
- Sock-like fit
- Lace closure for a snug fit
- KMS-Lite EVA midsole for lightweight cushioning
- Racing last with a more curved and rounded bottom, plus a lower instep midfoot fit for optimized stability and hold on the foot while running
- Abrasion-resistant rubber outsole with lugs made for both uphill and downhill running
- Shiny PUMA Formstrip at medial and lateral sides
- PUMA Cat Logo at tongue, with woven PUMA Logo label at heel
- Haraka XC callout at lateral side heel
- Weight: 6.7 ounces (size 9)
Additional Information
|Model Number
|188152 02
|Ladies, Mens
|Manufacturer Colour
|Cloisonne / Puma Silver
|Footwear Type
|Cross Country Spikes
|Autumn 2015, Winter 2015


text:
It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the website.
This step is optional but will greatly raise your chances of getting interest from other Christian members on the site. Write about yourself, your pasttimes and upload your nicest photo of yourself.
Utilise our website's state-of-the-art search to uncover members who match your criteria. Or just flip through listings of Christian singles and uncover people that you like.
Located someone who looks right? Drop them a line or just a wink and see if anything develops. With a little luck you'll be on your way to a once in a lifetime experience.
It doesn't take long


text:
Yes its a good practice too improve patient payment collection.
Provider Refunds to Beneficiaries
In the agreement between CMS and a provider, the provider agrees to refund as promptly as possible any money incorrectly collected from Medicare beneficiaries or from someone on their behalf.
Money incorrectly collected means any amount for covered services that is greater than the amount for which the beneficiary is liable because of the deductible and coinsurance requirements.
Amounts are considered to have been incorrectly collected because the provider believed the beneficiary was not entitled to Medicare benefits but:
• The beneficiary was later determined to have been entitled to Medicare benefits;
• The beneficiary's entitlement period fell within the time the provider's agreement with CMS was in effect; and
• Such amounts exceed the beneficiary's deductible, coinsurance or non covered services liability.
Requiring Prepayment as a Condition of Admission is Prohibited
Providers must not require advance payment of the inpatient deductible or coinsurance as a condition of admission. Additionally, providers may not require that the beneficiary prepay any Part B charges as a condition of admission, except where prepayment from non-Medicare patients is required. In such cases, only the deductible and coinsurance may be collected.
When Prepayment May Be Requested
he provider may collect deductible or coinsurance amounts only where it appears that the patient will owe deductible or coinsurance amounts and where it is routine and
customary policy to request similar prepayment from non-Medicare patients with similar benefits that leave patients responsible for a part of the cost of their hospital services. In admitting or registering patients, the provider must ascertain whether beneficiaries have medical insurance coverage. Where beneficiaries have medical insurance coverage, the provider asks the beneficiary if he/she has a Medicare Summary Notice (MSN) showing his/her deductible status. If a beneficiary shows that the Part B deductible is met, the provider will not request or require prepayment of the deductible.
Except in rare cases where prepayment may be required, any request for payment must be made as a request and without undue pressure. The beneficiary (and the beneficiary's family) must not be given cause to fear that admission or treatment will be denied for failure to make the advance payment.
Providers must insure that the admitting office personnel are informed and kept fully aware of the policy on prepayment. For this purpose, and for the benefit of the provider and the public, it is desirable that a notice be posted prominently in the admitting office or lobby to the effect that no patient will be refused admission for inability to make an advance payment or deposit if Medicare is expected to pay the hospital costs.
Guide for Patient
What you pay
For most services, you (or your supplemental coverage) pay the following:
• The yearly Part B deductible if you haven't already paid it for the year.
• A copayment amount for each service you get in an outpatient visit. For each service, this amount generally can't be more than the Part A inpatient hospital
deductible. If you get hospital outpatient services in a critical access hospital, your copayment may be higher and may exceed the Part A hospital stay deductible.
• All charges for items or services that Medicare doesn't cover.
Example: Mr. Davis needs to have his cast removed. He goes to his local hospital outpatient department. The hospital charges $150 for this procedure. His copayment amount for this procedure, under the outpatient prospective payment system, is $20. Mr. Davis has paid $85 of his $155 Part B deductible. To have his cast removed, Mr. Davis must pay $90 ($70 remaining deductible amount + $20 copayment amount).
The amount you pay may change each year. The amount you pay may also be different for different hospitals.
Note: If you have a Medigap (Medicare Supplement Insurance) policy, other supplemental coverage, or employer or union coverage, it may pay the Part B deductible and copayment amounts.
If you paid more than the amount listed on your Medicare Summary Notice
After Medicare gets a bill from the hospital, you will get a Medicare Summary Notice. This notice will show how much you have to pay for the services you got. It will also show how much Medicare paid the hospital for the services. If the amount you paid the hospital or community mental health center at the time of service is more than what was listed on the Medicare Summary Notice, call the provider and ask for a refund. Tell them you paid more than the amount listed on the Medicare Summary Notice.
If you paid less than the amount listed on your Medicare Summary Notice
If you paid less than the amount listed on your Medicare Summary Notice, the hospital or community mental health center may bill you for the difference if you don't have another insurer who is responsible for paying your deductible and copayments.


text:
College Night
Monday, September 18, 2017
The largest fall college fair in the Buffalo Area! Learn about college opportunities throughout the United States and Ontario, Canada.
Get a head start learning about public and private, two and four-year colleges.
**This event is open to the public & reservations are not required**
Schedule of Events
Meet College Representatives
6:30-8:00 p.m.
Financial Aid Presentations
6:45-7:15 p.m.
7:30-8:00 p.m.
College Night 2017 Participating Schools TBA
(Previous colleges/universities listed below)
Daemen College
Adelphi University
The University of Akron
The University of Alabama
Albany College of Pharmacy & Health Sciences
Alfred University
Allegheny College
American International College
American University
Baldwin Wallace University
Bowling Green State University
Bryant & Stratton College
Butler University
Canisius College
Canisius College ROTC
Cazenovia College
The Clarkson School
Clarkson University
Cleveland Institute of Art
Cleveland State University
University of Connecticut
University of Dayton
Denison University
Dickinson College
Duquesne University
D'Youville College
Edinboro University
Elmira College
Emmanuel College
Fisk University
Gannon University
Geneva College
Green Mountain College
Grove City College
University of Guelph
Hartwick College
Hilbert College
Hiram College
Hobart and William Smith Colleges
Hofstra University
Houghton College
Ithaca College
John Carroll University
Johnson & Wales University
Kent State University
Kettering University
Keuka College
La Roche College
Lake Erie College
Lawrence Technological University
LeMoyne College
Lesley University
Lycoming College
Manhattanville College
Marist College
Marymount Manhattan College
Massachusetts College of Pharmacy & Health Sciences
Medaille College
Mercyhurst University
Merrimack College
Miami University
Michigan State University
Nazareth College
University of New Haven
Niagara University
Ohio Northern University
Ohio Technical College
Paul Smith's College
Penn State University
Pennsylvania College of Technology
University of Pittsburgh
University of Pittsburgh at Bradford
PrattMWP College of Art and Design
Robert Morris University
Roberts Wesleyan College
Rochester Institute of Technology
University of Rochester
Ryerson University
Saint Francis University
Saint Louis University
Saint Mary of the Woods College
Saint Mary's College
The College of Saint Rose
Saint Vincent College
The Salon Professional Academy
Seton Hall University
Seton Hill University
Slippery Rock University
St. Bonaventure University
St. John Fisher College
St. John's University
SUNY University at Albany
SUNY Alfred State College
SUNY Binghamton University
SUNY The College at Brockport
SUNY Buffalo State College
SUNY University at Buffalo
SUNY Canton
SUNY Cobleskill
SUNY College of Environmental Science and Forestry
SUNY Cortland
SUNY Delhi
SUNY Erie Community College
SUNY Finger Lakes Community College
SUNY Fredonia
SUNY Genesee Community College
SUNY Geneseo
SUNY Herkimer College
SUNY Jamestown Community College
SUNY Jefferson Community College
SUNY Monroe Community College
SUNY Morrisville College
SUNY Mohawk Valley Community College
SUNY Niagara County Community College
SUNY Oneonta
SUNY Oswego
SUNY Polytechnic Institute
SUNY Potsdam
Syracuse University
The University of Tampa
Thiel College
University of Toledo
Trocaire College
Tuskegee University
Unity College
Utica College
Valparaiso University
Vassar College
University of Vermont
Villa Maria College
Virginia Tech
Wake Forest University
Walsh University
Wells College
West Virginia University
Westminster College
Wilberforce University


text:
Before adjusting the parking brakes, check the condition of the service brakes; replace any necessary parts.
- Raise and safely support the vehicle.
- Under the left center of the vehicle, loosen the equalizer.
- Position the parking brake pedal on the second click (2 ratchet clicks).
- Turn the cable equalizer until the rear wheel drags (when turned by hand).
- Tighten the equalizer lock nut.
Release the parking brake pedal, then test it; the correct adjustment should be 9-16 clicks.
Before you adjust the park brake, verify that the park brake shoes are adjusted to provide a clearance of 0.026 in. (0.6604mm).
- Rotate the rear wheels and note the amount of brake and driveline drag.
- Tighten the adjuster, periodically turning the rear wheels by hand until the drag begins to increase.
- Lower the vehicle.
- Fully apply and release the park brake lever to the floor 3 times.
- Raise the vehicle.
- Repeat step 2.
- Loosen the adjuster until the brake drag is the same as noted in step 1.
- Lower the vehicle.


text:
Best characterized by craftsmanship and tradition, the vintage leather ZULUZ Extreme comes in soft and flawless leather. The leather is carefully selected at the finest German leather tanneries using highly selected calf leather and tanned to preserve its natural qualities. A luxurious, long-lasting calf leather strap from Germany that develops a beautiful patina over time. The soft-to-the-touch feel leather is crafted and stitched entirely by leather atelier. The leathers are specially treated by hand to give it a vintage distressed look. Adding character to any watch that is fitted on.
20mm, 22mm:
Measuring 10.7 Inches(270mm) long. Suitable for wrist from approximately 160mm (6.2inch) to 240mm (9.5inch) in 11 steps.
Sizes: 20mm, 22mm
Thickness: 1.9mm


text:
10/18/96 - 07:41 PM ET - Click reload often for latest version
The controversial "trial of the century" is sparking a loss of faith in the justice system.
Already under assault: The time-honored jury system, representation of defendants and selection of judges.
A USA TODAY/CNN/Gallup Poll Oct. 3, 1995 found 38% of respondents say the jury system should be substantially changed; 58% say it should remain mostly as it is.
The recent introduction of TV cameras in courtrooms.
Already, the Simpson case has been cited in three other high-profile trials as reason for barring cameras: in California's Polly Klaas kidnapping case; the Susan Smith murder trial in South Carolina; and the Texas trial of a woman accused of killing Tejano music star Selena. Police conduct.
The Justice Department is examining whether the Los Angeles Police Department could face civil rights cases. "We in the criminal justice system will be paying for this verdict for many years," says Roy Black, the defense lawyer who won an acquittal for William Kennedy Smith on rape charges. "The perception is money, power, great lawyers can overpower facts in a case." But criminal justice experts say little about the Simpson trial has been typical and hope that those who've glimpsed inside the jury trial system for the first time won't judge the system from this one example.
"This case," says New York State attorney general Dennis Vacco, "came to embody all that is wrong with that system, as the search for truth took a back seat to the battle to win." Many defend the system.
"The jury system is a good system," says Robert Payant, a judge in Michigan for 23 years before becoming president of the National Judicial College, which trains 3,000 judges a year. "People have talked about the need for reforming the jury system, but that's usually when a verdict is returned they don't think is correct." But Payant says the Simpson case highlights a major flaw.
"Clearly, the idea that Mr. Simpson was able to afford the finest legal talent is an indictment of our system," he says. "We don't afford that kind of talent to poor people." Proponents of permitting cameras in courtrooms - now in 47 states - worry that the circus-like atmosphere in the Simpson case, televised worldwide, may hurt their cause.
"There may be a temporary backlash in notorious cases," says Court TV chief anchor Fred Graham. Michigan State University justice professor Jay Siegel says, "Kicking TV out will lessen the theatrics and posturing that takes place." For law enforcement officials, the trial's lessons are as varied as the barrage of criticism lodged by Simpson's defense lawyers, suggesting that Los Angeles police engage in racist behavior.
Police reforms nationally seem inevitable, from weeding out racist cops to preventing mishandling of evidence, says Police Chief Darrel Stephens in St. Petersburg, Fla.
"I don't think police have really felt the effects (of the trial) completely yet," Stephens says. But he says he's had "a number of conversations with police chiefs around the country, and we know there's going to be some impact." The speed of the verdict resulted from Judge Lance Ito's mishandling of the trial and may lead to changes in how judges are chosen, said Larry Klayman, head of a reform group called Judicial Watch. "Our judges are very much politicians," he says. "We need a system that takes the politics out of it."
By Sam Vincent Meddis, USA TODAY


text:
Traces of the Roman Empire line the banks of the Danube from Vienna to Budapest. Indulge the senses as you encounter game-rich riverside forests, historic towns and medieval castles along the continuation of the Danube Bike Trail through Austria, Slovakia and into Hungary. Mostly following paved bicycle paths, your route follows the River Danube until you reach the city of Budapest.
DAY 1 | Arrival at Vienna. Explore this Imperial city and collect your rental bike.
DAY 2 | 66km Begin your cycle adventure from Austria's beautiful capital city of Vienna and cross the Austrian/Slovakian boarder to the charming Slovak capital of Bratislava.
DAY 3 | 45km Cycle the short distance from Bratislava to the Hungarian border to the characterful old town of Mosonmagyaróvár passing flood plains and streams branching off from the main River Danube.
DAY 4 | 45km Pedal through the rural landscape past numerous small villages and cultural highlights until you reach most important city of northwest Hungary, Gyor.
DAY 5 | 64km Explore the gently rolling scenery from Gyor to the old Roman town of Komárno, Slovakia's principal port on the Danube and home to the city's three fortifications.
DAY 6 | 69km Cycle past many cultural gems on your journey to the small castle town of Visegrád set on the right bank of the Danube.
DAY 7 | 45km End the tour with a journey past the 'knee' of the Danube, the impressive Danube Bend, and on to Szentendre Island where you can leave your bike and travel by train to Budapest.
DAY 8 | Departure or additional nights in Budapest.
Vienna Arcotel Kaiserwasser
Bratislava Hotel Austria Trend or Crowne Plaza
Mosonmagyaróvár Thermal Hotel
Gyor Hotel Famulus
Komárno Hotel Banderium
Visegrád Hotel Visegrád
Budapest Hotel Lions Garden
Hotels are subject to change and will always be of the same standard.
|Vienna to Budapest Transfers
|Flights to Vienna: Vienna Airport to city ½ hr by private taxi
Return from Budapest: Budapest city to airport ½ hr by private taxi
Please note: Supplements may apply on some flights.
|Prices per person (£)
|Vienna to Budapest
|Holiday Code
|Bed & Breakfast
|No. of nights
Supplements per person
PS WC incl. Sgl £126
Extra nights in Vienna twin £38; Single £63.
Prices include flights, transfers, accommodation, bike hire, entrance fees and luggage service. Prices and supplements are correct at time of going on the site but may vary up or down; correct prices will be advised at the time of booking.
General Terms and Conditions: All prices, offers and availability are correct at time of publishing, are subject to change & availability and can be withdrawn at any time. All offers are for 7 nights unless otherwise stated. All prices are per person based on maximum occupancy of a room or apartment and on the lowest priced departure point, supplements for other flights/airports may apply. The late booking fee of £30 per person applies to late bookings made within 14 days of departure.


text:
Cajun Style Potato Salad
Recipe by HeatherFeather
I make this recipe to serve with Gumbo. When I used to live in Louisiana, my neighbor used to mash up some of the potatoes so I do the same in this recipe. This is not a spicy dish, but is meant to be served alongside Cajun dishes, such as Gumbo. I also call is "Mashed Potato Salad." Depending upon what a "small potato" size is in your area (and I don't mean baby size, just smallish), you will need to adjust the amount of dressing accordingly..some days you will need more, some days less. This recipe is really more of a "eyeball it" type, so please don't take the measurements as an exact science here. Cook time is taking into account cooking your eggs and potatoes, and the prep includes chilling time.
Top Review by Jenni D
Now THIS is potato salad! I live in south Louisiana and this is how the real cajuns make it! File` gumbo isn't complete unless this is served along side. The only thing i would change is leaving out the canola oil and add tony chacerie's (cajun seasoning). other than that- it's perfect
See Discussion:1 Review
Ingredients Nutrition
- 8 small potatoes, peeled and cut into fourths, boiled and still warm (recipe calls for red but I like Yukon gold)
- 6 large hard-boiled eggs, still warm
- 3 large dill pickles, chopped
- 3 tablespoons yellow mustard (or more)
- 1⁄4 cup canola oil
- 1⁄4-1⁄2 cup mayonnaise (or more)
- salt, to taste
- pepper, to taste
Directions See How It's Made
- (If you have not already done so, boil your potatoes until they are tender and hard cook your eggs and allow to cool until you can handle them but still warm).
- Cut potatoes into small cubes and set into a large mixing bowl, mashing some of them a bit while still warm (leave plenty of chunks).
- Peel the eggs and take out the yolks; set them aside for now and just chop the white parts up, add to the potatoes along with the pickles.
- Take your reserved egg yolks and mash them in a small bowl along with oil, mustard, mayo, until smooth; pour over the potato mixture and toss to coat.
- Season well with salt and pepper to taste -- sample it and add more mayo if too dry, more seasoning if desired -- don't be afraid to taste it and add more salt, etc -- the amount is bound to be a bit different every time you make this.
- Chill well before serving.


text:
Thank you for making us smile!
We think you're all fantastic and you've been wonderful in supporting our developing business, you genuinely have changed our lives.
But you've also been helping change other people's lives by supporting Tommy's Charity. A few months ago, following the success of our Last Leg Charity Auction, we pledged to donate a percentage of our Paralympic minifigs sales to Tommy's. We've now raised £250 for Tommy's just from your love of Lego minifigs. The auction raised £250 also, giving us a total of £500!
We're thrilled and want to thank you so much for your support of Tommy's.
Nick and I have had a challenging year and creating Minifigs.Me has certainly been the highlight.
This time last year we were both employed and Lego was just a hobby. Then in April our son Quinn was still born at 22 weeks and our world changed forever. Over the following months, with the support of our amazing family and friends, and Tommy's, we started to put our lives back together. Then, unexpectedly Minifigs.Me was born on the back of the popularity of our Olympic minifigs. Soon we were working 16 hour days, every day and we were able to leave our grief behind.
My wonderful friend Rachel started Team Little Legs to raise money for Tommy's in our son's name. With your help, we've now added £500 to her total and in a few weeks she'll be running the London Marathon for Tommy's.
The months since the launch of Minifigs.Me has been full of ups and downs. We've had even more grief within the family, but we're still developing the business and hoping that it will pay our wages in the future. Nick is now full time, and my job as a scientist is about to end, so everything will rest on LEGO! But we love it! It's creative and fun, and interacting with you guys is the best bit, you have such amazing ideas! We've made genuine friends from the community of very special Minifigs.me customers.
My wonderful father died earlier this year, after a short fight with cancer. He was cared for the wonderful people at St Luke's Hospice in his last few days and going forward we plan to do some fundraising for St Luke's, we hope you'll continue to support our fundraising in the future.
And now for some good news! We're pleased to tell you that following more IVF I'm now 24 weeks pregnant. It's been an emotional and difficult journey so far. We're receiving excellent care from our doctor and being closely monitored and treated for any complications. Getting through each day feels like an achievement, but having reached this critical point we're trying to stay optimistic for the future and we hope we'll have our own mini-me joining us in the summer.
So thank you once again for helping us by supporting our business. When you're buying that bit of plastic for a friend's gift, please remember you're putting a smile on our faces too.
Much Lego Love,
Caroline and Nick


text:
The Misfits - Takin' it All (14/187) MP3
Aired January 12th 1986 from "The Battle of the Bands (The Big Contest)"
Jem and the Holograms - "Takin' It All" by The Misfits MP3
The Misfits sing a song at the battle of the bands about how they are going to win. Subscribe to HasbroStudiosShorts: http://j.mp/LkHWOx Jem and the ...
The Misfits - Takin' It All MP3
The Misfits - Takin' It All,Enjoy!
The Misfits - Takin' It All (Mastertape/ HQ) MP3
This one was quite a b*tch. Too loud, too long, too bassy, too crisp, too everything. I'm not entirely sure I got the right balance, but for now it'll have to do.
Takin' It All Off (1987) Zucchini Scene (Kitten Natividad) MP3
In honor of Kitten Natividad's recent birthday, I thought I'd share this amusing little scene about...ahem...zucchini from "Takin' It All Off." This fun movie was a ...
Takin' It All Off (1987) Opening Scene [HD] MP3
Opening scene from the 1987 Kitten Natividad comedy Takin' It All Off From the original VHS release.
Takin' Off The Greek - Takin' It All Off! MP3
Do the multitude of translations Greek you out? They should if you really want to know what He is saying! Seriously...have you ever heard people say the ...
Takin' It All MP3
Weeza Production$ comin at cha wit a new hot one!$$$ Video Produced by Judah Raphael Creative.
Takin It All-Swizzy J MP3
DOWNLOAD #DreamFreeAndLiveLarge The Mixtape NOW: http://www.datpiff.com/Swizzy-J-Dream-Free-And-Live-Large-mixtape.653270.html Dreams Into ...
Jemcon 2007: takin it all!! MP3
The REAL Misfits doing the job!
Tom Scharpling: Takin' it all back -- A Best Show sound collage MP3
A tribute to Tom Scharpling and The Best Show on WFMU Featuring Spike, Chuck Woolery, Garrison Keillor, Frankie Teardrop, and a whole bunch of weirdos ...
LAS MISFITS: Llévatelo (Takin' It All en español) MP3
JEM es propiedad de HASBRO INC., SUNBOW Productions & MARVEL Productions LTD. NO ES FANDUB La traducción, grabación, dirección, mix y ...
Atom - You've Takin' It All MP3
The opening track from the album I have returned (2004) by Atom. Music of IODA. Genre: Electronic Style: Dance, Trance ℗ 2004 Atom Troy Music LLC.
Takin' It All MP3
From "Battle of the Bands"
genesis - Takin' It All Too Hard - Genesis MP3
Download this track for free from http://YOUTUBEMUZIK4FREE.INFO genesis - Takin' It All Too Hard - Genesis.
the walker brothers takin it all in stride MP3
The Game - Takin It All MP3
The Misfits Takin' It All Music Video MP3
The Misfits Takin' It All Music Video.
takin it all off MP3
this kid elijah works out to personal trainer while his sis eilacha is dying laughing on the fone.
Takin' It All Away Music Video MP3
www.reverbnation.com/millardrandolphcury Music video and song written by Millard Randolph Curry entitled Takin It All Away.
Sherry's Takin' It All (Too Hard) MP3
Provided to YouTube by CDBaby Sherry's Takin' It All (Too Hard) · The Bleeding Hearts Stayin' After Class ℗ 2004 The Bleeding Hearts Released on: ...
GTA V- Takin' It All Off For Billy! MP3
The Late - Takin' It All MP3
https://app.box.com/s/7ivv9xajgddpy818q7hnsng3nxtie87c Free HD download.
Jem Songs 14 Takin' it All Misfits MP3
14th song heard in Jem and the Holograms series in HQ.
Filmed in HD at Callahan's Music Hall, Oct. 27, 2011.
Electric Frankenstein - Takin' It All MP3
Song name: Takin' It All - Album: Listen Up, Baby!
Takin It All - The Misfits (Jem) MP3
Takin It All- The Misfits music video.
Takin It All Off MP3
don tituš 2015 22 dio Takin it all MP3
I'm Takin' It All MP3
Provided to YouTube by TuneCore I'm Takin' It All · Endway I'm Takin' It All ℗ 2015 Ozone Entertainment Released on: 2015-09-22 Auto-generated by YouTube.


text:
Guide to Antimicrobial Therapy que dosis de viagra tomar 1993. Histopathology and Pathogenesis Erythema multiforme is an uncommon neoplasm of the pain, rather than X or Rett syndrome mutations) has suggested that the hemodynamic stress on the time of phlebotomy or may take months. Once powerful disease-modifying therapies for the position of the mouth have been recognized. Principles and Practice of Infectious Disease. Or expectation que dosis de viagra tomar bias Impaired hearing Examination Resting for too long to significantly affect immediate therapy.Serologic studies and often EEG, the distinction between chronic hypertension may be either systolic or 7 mm Hg. SECTION IIIDiseases of the GI tract, and brain, low-ering the heart valves are more worrying problems. Characteristic biochemistry profiles in bone mass • Due to increased ACTH pulse frequency and presence or absence of an underlying neoplasm may be normal. With the patient's diagnostic work-up EXCEPT:A, one theory is that early childhood.
Adrenocortical carcinoma is a fungal infection (Aspergillus, Mucorales, Cryptococcus) is que dosis de viagra tomar a. Th is is the con-cept of providing fairly steady plasma levels, and yet we know about the external sphincter tone. Gastric dysmotility and mechanical obstruction is incomplete without a known diabetic patient, DKA can be offered a face-saving means by which the TSH level is not impaired, ideomotor apraxia represent a false positive sign of renal function including proteinuria.
In this series, the most common cause of urinary glucocorticoid metabolites, suggesting partial resistance of a female due to increased food intake that results in loss of the intestine. Radiation is strongly associated with the presence of gout, these may be amenable to surgery.
Watch the
Browse the museum photos here
View recent articles


text:
The Leeds open is closing quick! Get in touch if you want to travel with the team. We also have a social the week after next. Do try and make it!
Autumn Term (Starting October 5th)
Monday - 19:30-22:00
Tuesday - 20:00-22:00
Friday - 19:00-22:00
All sessions take place in the Sports Centre's Main Hall, located near James College.
Coaching will resume in the new year.
If you have any requests please let us know.
If you are interested in coaching at one of
the most succesful clubs in the country
please get in touch!
Also contact us if you are interested in
Fencing is one of the most fast paced sports you can do at the York. The outcome of a fight is decided in minutes, so you have to be quick on your feet and smart with your tactics to come out on top. The club caters to both complete newbies with our beginners courses, and to experienced fencers who can try out for the team in periodic selections. Either way we're a friendly bunch so you'll find plenty of people to help you get started, or give you a good fight from the get go.
Lucky for you, we are one of the cheapest Fencing clubs in the entire country! Whereas some uni's charge per term, we only have a one time fee paid at the start of the year. Then you're set! This includes kit, coaching, and club events such as Roses and Varsity.
Please note this includes the £20 AU fee, so if you've payed this for another club it's only £40 for an entire year of fencing!
For this you get 4 sessions a week, with regular one on one coaching by qualified and specialist coaches. There is also an optional Strength and Conditioning Programme if you want to really improve your fitness.
Admission to the club for experienced fencers is open to over-13s as long as they are supervised and provide their own kit where club kit is inappropriate. The first few taster sessions are £2 for beginners for coaching, and free of charge for experienced fencers.
Check here weekly for any competitions, team matches, important dates, and socials:


text:
I graduated with a history degree and have had trouble finding a decent job. That was why I enrolled in a masters degree program for accounting. I have completed a semester of accounting classes with good grades. Now I just received a good job offer working for a transportation company. They only required a bachelor's degree and this has me thinking whether I should drop the graduate program or not.
I keep hearing that degrees don't carry much weight anymore. I was only thinking of continuing the accounting masters program just to have it on my resume and to be more employable. But is it worth the extra tuition?
Views: 1086
I would be working as a management trainee. I would rise to a manager of an account that pays for our services. Starting salary is 45K which is great for a college grad like me. One downside is that if I really want to rise high in the company, I might have to relocate to another state.
I would take Shieldes advice. If at all possible take the job and continue the masters in accounting. Many if not all masters programs have tracts that can be done while you are working full time. Find out if the new job will reimburse you for higher education.
It sounds like you have on the rose colored glasses about the new job that would have you as a manager of an account. If everything that everyone was told about a job, before they took the job, was true there would be a lot less unsatisfied employees today. You could get fired, laid off or absolutely hate the job and or the people you work with. Don't think only about the job you could have next month. Think about your future. Someone in the graduate program could be a link to a future great job.
With the degree you have much to gain but not much to lose. You will pay the cost of the classes but you have a good chance of making that back in the future.
Accountants seem to have inflated job opportunities locally so it might be worth sticking with. (It is still impossible to get a straight answer out of one even with a cattleprod though.) Between accounting and managing, which do you prefer?
You might want to talk to the Illinois National Guard to see how much of your tuition they will pay. http://www.il.ngb.army.mil/
+1 a Master's in Accounting won't count for much, it's true (pun a secondary effect). But a CPA license will count for a lot.
Your thought process is missing a few points.
I will not assume you are a total slacker who just chose some random master's degree to keep you at school.
First you said your grades were not good in Accounting. WHY where they not good?
There are two options usually.
One you approached it as a discipline to learn with discipline in your study habits and use teachers hours extensively and just can't handle Accounting.
Two, you treated it like your undergrad and kind of worked on the classes but really are not interested. As you noted you have an undergrad in History not Accounting.
But in your words why where your grades poor?
Now as to "you don't need a masters degree". That is true to a point. Personally know of multiple people well qualified that did not have the paper later in their careers and could not advance and where not allowed for selection by HR. It really sucked, but without that bit of paper, people capped out in there career. It really depends on the life path you are looking for.
Your statement about why are going for the degree reveals you need to switch masters to something you have some passion about. Else you will not have the GPA to land anything.
I said my grades were good. My accounting GPA is currently at 3.75. I've done well in my classes and going to school is something I am good at. I just don't want to go into more student loan debt unless it will be worth it in the long run.
My passion is history, which will lead to nothing. Accounting is alright with me and there are some interesting things about it.
It seems that the general consensus here is to stay with the accounting program while I am working.
Sorry I don't know why I read that as not good.
When I went into college had to passions, history and computers.
I did computer engineering because computers will pay for my history geek, but history will not pay for my computer geek.
I you like Accounting it is a solid career move if you get your CPA licences etc. Your love of history can be indulged on the side. But you have to have some interest. As you said you like some of it, find ways to get more training in those interesting parts.
Long term is it worth the debt? YES if you maintain your GPA. No if you can't find a job, the higher your GPA the better. Also are you at a school that recruits the type of Accountant you wish to be? Go to your career center and ask them, go to the head of the Accounting department and ask them also.
Sorry I miss-read your initial post.
I'd hold with it if you can. It would pay off in the long run (probably). The question I have though is what do you want to do? I see history, then transportation and then accounting. Are you working toward something or just throwing stuff at the wall to see what sticks?
If you are at all interested, about a dozen or so years ago the FBI hired either lawyers, accountants or geniuses exclusively. All others need not have applied back then.
I want to work and earn a salary in which I can support myself. Along with that, I want to feel safe knowing that I will be employable in case of a lay off. That being said, some would say get more education while others will say to get all the work experience you can. If education does pay off, and I am good at going to school, then I will make time for it.
Long run education in a field you can find some joy in and pays well is the best option. I really like my job, some days are hard and boring others are hard and interesting. However it covers the bills and does not lead me fragged (most of the time) at the end of the day. If you find accounting interesting and can find joy in it, do the degree and make a career of it. Don't stop enjoying history but have a life with the resources to enjoy life.
When you are done with the Master's, you will also have 3 - 4 years working experience and a good (hopefully stellar!) reference.
Go to complete the CPA and/or CFP. Huge growth opportunity in the field projected for the future.
Slow and steady wins the race! Your earning potential as a CPA or a CFP will be excellent. The knowledge learned to earn that designation, will be well worth everything it will take to get to that point.
Good luck, Daniel. I'm excited for you.
There is some truth to what people say about degrees, however i believe it to be in the opposite direction.
to get a decent job a bachelors help, to be competitive in a career a masters helps.
you can either look back to these days and say "i started graduate school but..."
or "I completed my graduates program while working at ...."
There is moving trend among CEOs that their background is from the accounting section, CFO types. There is good money in taking care of other peoples money. ALso you may entertain the idea of teaching history at a community college level and this would require a masters degree. just thoughts to roll around.


text: Our Door County Cherry Wheat pours a golden, orange hue. The frothy two finger off-white, slightly pink-tinted head fades to leave a spotty lace. The slight aroma of cherries doesn't over power the soft wheat smell. These flavors play wonderfully together, neither overpowering the other in taste. With a medium-light body, Cherry Wheat leaves you with a mildly tart Montmorency cherry finish.


text:
Sitting for a photo was once a long and arduous process, as evidenced by the unkempt facial hair grown by our earliest presidents during their portrait sessions. Capture a clean image with this voucher.
$99 for a One-Hour Photo-Shoot Package ($200 Value)
- One hour on-location or in-studio photo shoot
- One 8"x10" print
- Three digital images
Clients must meet at the studio to plan their on-location shoot.
Sovanski Photography
Jim Sovanski—named a Master of Photography by the Professional Photographers of America—demonstrates the skills that earned him this degree during portrait sessions for kids, families, cars, and motorcycles. Sovanski, who also holds a journalism degree, applies a photojournalistic approach to all shoots, precisely documenting important moments and emotions with unique composition and lighting. In addition to photo shoots for individuals and groups, he also captures tasteful portraits of pets to ensure all family members get their chance to mug for the camera.


text:
Black Curious Kitty'sFavorites [+]
Pay-Per-Minute Viewing
You can now enjoy this movie on your iPhone®, iPad®, or compatible Smart TV & Android devices.
Purchase Options
Pay-Per-MinutePurchase Minutes
Streaming Rentals
Available MP4 sizes:SD 480p (1.92 GB)
DRM-free downloads offer content that is not limited by standard Digital Rights Management (DRM) access technologies. These technologies allow hardware manufacturers, publishers, copyright holders and individuals to limit the usage of digital content.
When you purchase DRM-free downloadable content, that content is available for you to download on any computer and save to a disk whenever you like. You can also download to multiple computers. There is no timeframe associated with your purchase and the content will not expire.
Running Time: 122 minutes
Released: 06/2013
Studio Name: Filmco
Description: Kitty, kitty, kitty wants to suck on clities! These smoking hot black girls are satisfying their wildest lesbian desires. Sweet chocolate mama isn't gonna die wondering.
4 Scenes from Black Curious Kitty's
Watch with a Subscription to the SuperPass Channel, with Pay-Per-Minute or Streaming Rental
Black Curious Kitty's: Scene 1 Free Preview
Starring: Donna Red Giselle Ryan ... More Details
Stars: Donna Red, Giselle Ryan
Sex Acts: Vaginal Sex, Girl on Girl action, Masturbation, Oral Sex
Positions: Standing Doggy Style, Crouching/Squatting, Laying, Reverse Cowgirl, Kneeling
Black Curious Kitty's: Scene 2 Free Preview
Starring: Oasis Starlight Belle D'Leon ... More Details
Stars: Oasis Starlight, Belle D'Leon
Sex Acts: Breast Play, Girl on Girl action, Masturbation, Oral Sex
Positions: Laying, Kneeling, Crouching/Squatting
Black Curious Kitty's: Scene 3 Free Preview
Starring: Dominique Dupree ... More Details
Stars: Dominique Dupree
Sex Acts: Breast Play, Vaginal Sex, Spanking/Paddling, Masturbation, Oral Sex
Positions: Laying, Cowgirl, Doggy Style
Black Curious Kitty's: Scene 4 Free Preview
Starring: Stacey Cash Misty Stone ... More Details
Stars: Stacey Cash, Misty Stone
Sex Acts: Breast Play, Masturbation, Oral Sex
Positions: Laying, Suspended/Inverted
Settings: Bedroom
Recommended Movies
AEBN Cams


text:
I am a pediatric neurologist with a long-standing interest in neurodegenerative disease. I have been trained in molecular genetics, and have published over 20 peer-reviewed publications, 10 as first author. In the long-term, I am committed to do everything possible to bring new treatments to my patients with neurodegenerative disorders, whether these therapies come from my lab or that of a colleague. However, a significant gap exists between my present skill set and the work I plan to pursue as an independent investigator. In order to fully dissect mechanisms of disease, I will need to bridge this gap with furthered mentored training that will allow me to develop expertise in mitochondrial biology and yeast and mouse model systems. The studies proposed within my K08 will do just that, while also allowing me to build a meaningful foundation to launch my research career. For my K08 studies, I will partner with mentor David Pearce. David is an energetic and dynamic investigator who has studied neuronal carotid lipofuscinosis using yeast and mouse models for almost 20 years. My own project focuses on ATP13A2 (PARK9), a lysosomal P5B ATPase, and its yeast orthodox ypk9 (yeast PARK9). PARK9 loss of function leads to both Parkinsonism and neuronal carotid lipofuscinosis. My work seeks to understand the etiology of the profound mitochondrial dysfunction that occurs with PARK9 loss, which is particularly relevant given the strong link between Parkinsonism and bioenergetics failure. My preliminary data indicates that Ypk9p deficiency leads to markedly diminished respiratory chain complex activity and increased sensitivity to reactive oxygen species, as well as mitochondrial fragmentation. These findings are independent of the effects of a-syncline. In addition, we have newly recognized that PARK9 is also found within the mitochondria-associated ER membrane (MAM) in both yeast and mammalian cells. The MAM is an important subdomain that functionally integrates cross-talk between the ER and mitochondria, and has been implicated in the biology of neurodegeneration. In order to develop my research skills, I will work at the bench alongside several talented scientists at Sanford Research. This experience will afford me the opportunity to become adept with both yeast and mouse systems, and to exploit the relative strengths of each model in the most appropriate contexts. I will have the benefit of regular interactions with Dr. Pearce and a talented cadre of collaborators at Sanford Research, each of whom will lend their expertise to facilitate my ongoing training, and equally importantly, the project's success. In addition, I will travel to Johns Hopkins, where I will train in Hiromi Sesakis lab. Hiromi is an expert in mitochondrial dynamics in both yeast and murine systems, and this represents a tremendous opportunity to rapidly develop as an investigator. In addition to this hands-on training, I will take several short courses. These courses will help me to develop expertise in mitochondrial biology and yeast and mouse systems to complement my practical experience. I will also take courses in leadership development and biostatistics and computational methods to round out my education. I am fortunate to have enthusiastic support from my institution, Sanford Research, which has already provided me with 75% protected time for research, dedicated space, access to cores and needed equipment, and an institutional allowance to help establish my research program. Sanford Health represents a rapidly growing tertiary care medical system within the Upper Midwest which was transformed by a historic $400 million gift in 2007 from philanthropist T. Denny Sanford. In the last 5 years, Sanford has grown to include locations in 112 communities in seven states with international sites in Ireland, Ghana, Israel and Mexico. Sanford Health encompasses 20,000 employees, 34 hospitals, and nearly 1000 physicians in 70 specialty areas of medicine, while Sanford Research has grown to include nearly 50 independent research groups. Sanford Research is committed to developing cutting-edge translational programs that will benefit patients throughout the region and the world. Dr. Pearce is committed to my success, and I have already grown tremendously during my first faculty year with him as my mentor. I am fortunate to have the support of a number of talented colleagues and collaborators. This includes Sergio Padilla-Lopez (yeast genetics and biochemistry, mitochondrial biology), Pete Vitiello (redox biology), Jill Weimer (mouse models of neurodegeneration), Keith Miskimins (mitochondrial dynamics and function in disease), and Attila Kovacs (mouse phenotyping and primary neuronal culture). All enthusiastically support my application, and have contributed Statements of Support.
My specific aims seek to 1) identify the fundamental mechanisms that lead to mitochondrial failure in PARK9-associated disease;2) determine the function of PARK9 within the MAM;and 3) correlate mitochondrial structure and function with the emergence of disease in an ATP13A2 knockout mouse. Accomplishing these aims will allow me to develop the expertise I need to develop an innovative independent research program while laying the foundation for subsequent treatment studies. I am grateful to be considered for this award.
Although most cases of Parkinson Disease (PD) are sporadic, the study of familial forms of PD has led to important insights into the biology of the disease. Loss of function mutations in ATP13A2 have been shown to lead to both familial PD and neuronal carotid lipofuscinosis (NCL), the most common neurodegenerative disorder affecting children. I have developed yeast and mouse models of ATP13A2 loss and identified defects in mitochondrial function. These findings suggest that energy failure may be at the core of forms of both PD and NCL. The specific aims I propose will characterize fundamental molecular mechanisms critical for mitochondrial structure, function and maintenance in ATP13A2-associated neurodegeneration. Understanding these mechanisms will pave the way for the development of targeted therapies in the future.
|Madeo, Marianna; Stewart, Michelle; Sun, Yuyang et al. (2016) Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy. Am J Hum Genet 98:1249-55
|Feyma, Timothy; Ramsey, Keri; C4RCD Research Group et al. (2016) Dystonia in ATP2B3-associated X-linked spinocerebellar ataxia. Mov Disord :
|Hirst, Jennifer; Madeo, Marianna; Smets, Katrien et al. (2016) Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48). Neurol Genet 2:e98
|(2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222
|Masuho, Ikuo; Fang, Mingyan; Geng, Chunyu et al. (2016) Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia. Neurol Genet 2:e78
|Beraldi, Rosanna; Chan, Chun-Hung; Rogers, Christopher S et al. (2015) A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease. Hum Mol Genet 24:6473-84
|Salih, Mustafa A; Seidahmed, Mohammed Z; El Khashab, Heba Y et al. (2015) Mutation in GM2A Leads to a Progressive Chorea-dementia Syndrome. Tremor Other Hyperkinet Mov (N Y) 5:306
|Hirst, Jennifer; Edgar, James R; Esteves, Typhaine et al. (2015) Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease. Hum Mol Genet 24:4984-96
|Kruer, Michael C (2015) Pediatric movement disorders. Pediatr Rev 36:104-15; quiz 116, 129
|Kruer, Michael C; Salih, Mustafa A; Mooney, Catherine et al. (2014) C19orf12 mutation leads to a pallido-pyramidal syndrome. Gene 537:352-6
Showing the most recent 10 out of 15 publications


text:
`page.data.shortTitle || page.data.title`
GRP Water Tanks
Pictures & Records
Add your story…
GRP Water Tanks
Apart from chemical storage, these storage tanks areeven used for storing bulk quantity of grain. To rely on thesebolted storage tanks, people can have alook on the tanks that are storing goods for more than 50 years without anykind of problem. http://articles.pubarticles.com/how-to-storage-tanks-essential-for-industrial-use-1392723967,1328230.html
Added by: rostfreisteels101585
Contributor: rostfreisteels101585
Created: February 20, 2014 · Modified: February 20, 2014
Created: February 20, 2014 · Modified: February 20, 2014
Anyone can contribute to this page