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Select estrogens within the complex formulation of conjugated equine estrogens (Premarin®) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease
Issue Date2006-03-16
Zhao, Linqin
Brinton, Roberta Diaz
Article Version
Scholarly/refereed, publisher version
Published Versiondoi:10.1186/1471-2202-7-24
MetadataShow full item record
Background Results of the Women's Health Initiative Memory Study (WHIMS) raised concerns regarding the timing and formulation of hormone interventions. Conjugated equine estrogens (CEE), used as the estrogen therapy in the WHIMS trial, is a complex formulation containing multiple estrogens, including several not secreted by human ovaries, as well as other biologically active steroids. Although the full spectrum of estrogenic components present in CEE has not yet been resolved, 10 estrogens have been identified. In the present study, we sought to determine which estrogenic components, at concentrations commensurate with their plasma levels achieved following a single oral dose of 0.625 mg CEE (the dose used in the WHIMS trial) in women, are neuroprotective and whether combinations of those neuroprotective estrogens provide added benefit. Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER). Results Cultured basal forebrain neurons were exposed to either β-amyloid25–35 or excitotoxic glutamate with or without pretreatment with estrogens followed by neuroprotection analyses. Three indicators of neuroprotection that rely on different aspects of neuronal damage and viability, LDH release, intracellular ATP level and MTT formazan formation, were used to assess neuroprotective efficacy. Results of these analyses indicate that the estrogens, 17α-estradiol, 17β-estradiol, equilin, 17α-dihydroequilin, equilinen, 17α-dihydroequilenin, 17β-dihydroequilenin, and Δ8,9-dehydroestrone were each significantly neuroprotective in reducing neuronal plasma membrane damage induced by glutamate excitotoxicity. Of these estrogens, 17β-estradiol and Δ8,9-dehydroestrone were effective in protecting neurons against β-amyloid25–35-induced intracellular ATP decline. Coadministration of two out of three neuroprotective estrogens, 17β-estradiol, equilin and Δ8,9-dehydroestrone, exerted greater neuroprotective efficacy than individual estrogens. Computer-aided analyses to determine structure/function relationships between the estrogenic structures and their neuroprotective activity revealed that the predicted intermolecular interactions of estrogen analogues with ER correlate to their overall neuroprotective efficacy. Conclusion The present study provides the first documentation of the neuroprotective profile of individual estrogens contained within the complex formulation of CEE at concentrations commensurate with their plasma levels achieved after an oral administration of 0.625 mg CEE in women. Our analyses demonstrate that select estrogens within the complex formulation of CEE contribute to its neuroprotective efficacy. Moreover, our data predict that the magnitude of neuroprotection induced by individual estrogens at relatively low concentrations may be clinically undetectable and ineffective, whereas, a combination of select neuroprotective estrogens could provide an increased and clinically meaningful efficacy. More importantly, these data suggest a strategy for determining neurological efficacy and rational design and development of a composition of estrogen therapy to alleviate climacteric symptoms, promote neurological health, and prevent age-related neurodegeneration, such as AD, in postmenopausal women.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Zhao, Linqin and Roberta Diaz Brinton. "Select estrogens within the complex formulation of conjugated equine estrogens (Premarin®) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease." BMC Neuroscience 2006, 7:24 http://dx.doi.org/10.1186/1471-2202-7-24
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PHILADELPHIA Ś No one has influenced Eagles quarterback Nick Foles more this season than Trent Edwards, the Stanford geek who has molded his rookie counterpart into a lean, mean fighting machine.
When Foles fired that winning touchdown pass to Jeremy Maclin as time expired in Tampa, Edwards felt a little like he was in a hospital delivery room.
ōI was extremely proud,ö Edwards said. ōItÆs one of those things where, I donÆt want to say proud father but IÆve been with him for six months now. ThereÆs practice, training camp, OTAÆs and all the film you watch. To have it kind of come together in one moment right there where itÆs the last play of the game, where he came to the sideline, called the play and then executes the play and then we walk off of that field with the win you just feel happy, proud. ThereÆs a variety of adjectives I could give you ģ IÆm just happy for Nick.ö
Edwards will be happier for Foles if the third-round pick out of Arizona can hang in there tonight when the Eagles oppose the Cincinnati Bengals at Lincoln Financial Field (8:20, ABC, WIP 94.1-FM).
The Bengals (7-6) are better coached than the Buccaneers, who ranked last in the league in passing defense. Defensive coordinator Mike Zimmer invents a new zone blitz package weekly. Defensive end Geno Atkins (10 1-2 sacks) has games in which heÆs unblockable. The Bengals lead the league in sacks. They bring a lot of heat right up the middle.
While Foles threw for 381 yards and two touchdowns, and rushed for another score, he was sacked six times in the 23-21 win over the Bucs.
ōIÆm going to have to do a great job with blitz pickup and we need to execute our offense,ö Foles said. ōWe need to run effectively and throw effectively. The big thing is to run our offense well and execute well.ö
Edwards will do everything he can to prepare Foles for the Bengals. The same can be said of the Eagle coaching staff, acutely aware how important it is to get rookie running back Bryce Brown untracked this week. To beat the Bengals pass rush down, youÆve got to run. ItÆs that simple.
ōThey do a lot of things with fire zones and blitzes that you have to be ready for, and IÆm talking from a quarterbackÆs standpoint and a protection standpoint,ö Eagles coach Andy Reid said. ōThey do everything that you can do to maximize a defense, and theyÆre going to show it to you.ö
The Eagles and Foles began game-planning for the Bengals when they werenÆt trying to figure out the Bucs. Edwards explained how he strategically text messages highlights and key points to Foles along with the obvious Ś donÆt be late for this meeting or that meeting. To say the duo is close is an understatement. Foles offered Edwards a place to live for two months.
ōOn a regular basis weÆre pretty close,ö Edwards said. ōAnd that just comes with the territory. I think you kind of have to be that way. HeÆs helping me out a lot and I hope IÆm helping him out, too.ö
Foles credited Edwards and veteran quarterback Michael Vick, among others, with aiding in his development. Foles always is careful to include all of his teammates and avoid even a shred of controversy. Reid said Edwards has helped prepare the rookie to take on the media.
ōWhen Nick is here, Trent is here Ś they do all of this stuff together,ö Reid said. ōI just think it has been a real positive for him in terms of understanding the game, not only the game schematically but the game as a whole with the media and all the attention and everything that comes with it.ö
Edwards, who doesnÆt have a Twitter account, says Foles recognizes how to act off the field without his help. Whatever assistance Edwards provides, itÆs easily remembered.
ōI think the big thing is to be who you are,ö Foles said. ōIÆm going to tell you how I feel and I think you just stay true to who you are as a person. ThatÆs what IÆve talked to him about.ö
Foles has thrown three touchdown passes and no interceptions in his last two starts after getting intercepted three times in his first two starts. It wonÆt be a coincidence if Foles does well against the Bengals.
Though itÆs early, Edwards believes Foles is special.
ōI always have,ö Edwards said. ōIÆve always believed in him and IÆve felt like heÆs got Ś I donÆt know if moxie is the word Ś but just the right mentality.
ōThere was a play in the Dallas game when he got hit probably as hard as heÆs gotten hit in a long time. The very next play it was third-and-10 and he completes a ball inside to a slot receiver. I always judge quarterbacks based off of plays that they make after they get hit really hard. If they can stand in there and execute.
ōAnd heÆs done that on a consistent basis.ö
Even a proud pop canÆt ask for much more than that.


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This week "South Park" aired its Season 18 premiere episode revolving around launching a Kickstarter for a company that essentially does nothing. But even a company that useless needs to have a catchy name.
Taking advantage of the canceled trademark voided by the Patent Office earlier this year, Eric Cartman quickly chose the name "Washington Redskins" for his Kickstarter company with the motto: "Go f–k yourself."
"The Redskins has been on the forefront of Kickstarter as a company that is always finding new and exciting ways to tell people to go fuck themselves," Cartman says boastfully, before revealing his logo improvements.
Of course, this news wasn't well-received by Dan Snyder, owner of Washington's football team, who has stubbornly refused to change the racially disparaging moniker of his team.
RECOMMENDED: 'The Daily Show' To Take On Washington Redskins
"I know I can't legally make you stop using our name, but won't you just do it out of decency?" a concerned Snyder confronts Cartman who responds by saying:
"We can't just change the name of our company because it's, like, super-hard. But, hey — from one Redskin to another, go f–k yourself."
Despite Cartman giving him the cold shoulder, Snyder vows to stay determined in order to strip the lousy start-up of its name.
"We cannot give up," says Snyder to his boys. "Don't let them win."
The season premiere also incorporates current issues like crowdfunding, ISIS, and, most importantly, the ongoing controversy surrounding NFL Commissioner Roger Goodell and his mishandling of the infamous domestic abuse issue.
Watch the complete episode in the video below:


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Doctor insights on:
Hcv Infection Symptoms
What can a person with HCV infection do to protect their liver?
HCV: Yes, avoid alcohol. But, also discuss treatment options with a gastroenterologist or infectious disease specialist. ...Read moreSee 1 more doctor answer
Hepatitis C (Definition)
Hepatitis c is a virus that replicates (makes copies of itself) in the human liver. People can be infected by exposure to even very small amounts of blood. Over 20 to 40 years it can cause scarring of the liver, and severe scarring is called cirrhosis. People can be tested for exposure with an antibody test. If that is positive, they need a test for the virus itself ...Read more
What should persons with HCV infection do to protect their liver?
No Alcohol: The best thing that can be done is to not drink any alcohol. Also, there is some data suggesting that regularly smoking marijuana makes the liver disease worse. Being overweight can cause fatty liver which can also contribute to worsening hcv. ...Read moreSee 2 more doctor answers
What is the risk of carring HCV infection from a wife to her husband by sexual intercorse ?
Real: From my reading, most couples in which one partner is infected and the other is not do not transmit the infection. ...Read more
How many days after infection with HCV to be detected with pcr?
The RT-PCR for HCV: Can be positive within days, 7-10 or so, after exposure, in comparison to to 70-90 days or so to develop acute disease symptoms. Many cases of acute hcv are silent. ...Read more
When is a cut/wound sealed? If you pick a pimple and it bleeds but then stops. At what point is it protected from infection like HCV if contact blood?
Skin injury: The answer is in stages. the first stage is stop bleeding. It has some protection then, Dont worry about catching something from your own blood. The cells close the wound.by regrowth. It slowly closes over a couple of days. If it is clean, they grow faster. Withing 3-4 days it is closed. The wound heals side to side so the narrower it is the faster it heals. ...Read moreSee 1 more doctor answer
When might a specialist (gastroenterologist or hepatologist) be consulted regarding the management of HCV infection?
When diagnosed: Complex disease, complex management issues, changing medications, monitoring. Should be followed by a doc experienced in the management of the disease. ...Read more
I've read about chlamidophila pneumoniae and its way making immune system busy, i tested positive due to an old infection, could that delay anti HCV ?
Not specific: You would have to be more specific. What do you mean by "delaying anti hcv"? ...Read more
I'm a hcv+, had a severe uti & kidney infection last month and now diag with enlarged spleen, is it related to infection in anyways, what to do,advice?
Splenomegaly: A number of infections and diseases can contribute to an enlarged spleen. . Viral infections (like mononucleosis), bacterial infections (like syphilis or endocarditis), parasitic infections (like malaria), leukemias or hemolytic anemias. ...Read more
If i'm on Trileptal,can I safely can take Tylenol (acetaminophen) approx. 3 times weekly at 500-750 mg/day,to manage headaches and joint pain due HCV infection?
Yes, you can: However, for a patient with liver disease or taking other medication that can damage the liver, Tylenol (acetaminophen) dosing should be reduced to about 2 grams/day. Simple analgesics such as aspirin or Tylenol (acetaminophen) can produce MOH (medication overuse headache). Of course, always ask your doctor for more information about your individual situation. ...Read more
My hepatitis C antibody reactive(151.7).But in quantitative Hcv PCR test HCV RNA is less than 30 Iu/ml.Doctor said i have no hepatitis C infection.
Cleared: You were exposed to hepatitis C but you did not get the chronic, active infection. You, fortunately, were able to clear this infection. You are very lucky. ...Read more
Infection (Definition)
Infections are invasions of some other organism (fungus, bacteria, parasite) or viruses into places where they do not belong. For instance, we have normal gut bacteria that live within us without causing problems; however, when those penetrate the bowel wall and enter the bloodstream, ...Read more


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In April of 1972, SEAL Lieutenant Tom Norris risked his life in an unprecedented ground rescue of two American airmen who were shot down behind enemy lines in North Vietnam, a feat for which he would be awarded the Medal of Honor - an award that represents the pinnacle of heroism and courage.
Just six months later, Norris was sent on a dangerous special reconnaissance mission that would take his team deep into enemy territory. On that mission they engaged a vastly superior force. In the running gun battle that ensued, Lieutenant Norris was severely wounded; a bullet entered his left eye and exited the left side of his head. SEAL Petty Officer Mike Thornton, under heavy fire, fought his way back onto a North Vietnamese beach to rescue his officer. This was the first time Tom and Mike had been on a combat mission together. Mike's act of courage and loyalty marks the only time in modern history that the Medal of Honor has been awarded in a combat action where one recipient received the medal for saving the life of another.
By Honor Bound is the story of Tom Norris and Mike Thornton, two living American heroes who grew up very differently, entered military service and the Navy SEAL teams for vastly different reasons, and were thrown together for a single combat mission - a mission that would define their lives from that day forward.
©2016 Tom Norris & Mike Thornton; foreword: Bob Kerrey; preface: Drew Dix; introduction: Dick Couch (P)2016 Macmillan Audio
"Outstanding and inspiring story and book"
Really loved listening to this. Inspiring as well as informative. I learned a lot about the war in Vietnam, and the place these two men occupied. Dick Couch did a great job. Highly recommend.
Missouri Veteran
"A Hero's Story"
This book is the tale of two SEALs who went to great length to accomplish their mission, and at the same time, take care of each other. The description of the events is very good, and the description of the rescues riveting.
"Great story about 2 American hero's"
Mike Thornton and Tom Norris are true heroes. Their story is inspirational and bone chilling. Each of them went directly into the face of danger to save lives. Amazing story of character, perseverance and friendship/brotherhood! Most highly recommended!
"great story of two incredibly brave CMOH winners.."
A tremendous story that follows the two lives, the two stories of two very brave Americans. The narration is spot on and one cannot be helped but be moved by their story of heroism. What a great read!
"Amazing Americans"
To incredible human being we are so lucky to have them. also narrated in red
"Incredible American Treasures"
I would recommend this due to the ease of understanding the story; whilst not getting too involved in the manusha of the politics of the time. It was an incredble journey into the actions that define true heroism, courage, and grace under fire.
When Mike; against the advice and suggestion of his team went back for his fallen team mate Tom with the ethos of "No Man Left Behind"
The pronunciations of the cities and towns in Vietnam, combined with a reverence to the story as a friend to these heroes.
Great job connecting the characters, story tellers and reader to complete a true connection to the events that occurred in the text.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


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Creatinine and BUN tests are performed to measure renal function, filtration and over all organ health. These 2 tests, along with the creatinine clearance test, are very closely related and will help the healthcare professional understand the functional status of multiple organ systems.
They are easy and inexpensive tests to perform and frequently part of a normal blood screening.
What is BUN?
BUN stands for Blood Urea Nitrogen. It is an indirect and rough measurement of renal (kidney) and liver function, measuring the amount of urea nitrogen in the blood. (Urea is formed in the liver as the end product of protein metabolism and digestion.)
During ingestion, protein is broken down into amino acids. In the liver these amino acids are catabolized and ammonia is formed. All the ammonia molecules combine to form urea, which is then deposited in the blood and transported to the kidneys for excretion.
BUN is directly related to the metabolic function of the liver and excretory function of the kidney. Patients who have elevated BUN levels are said to have azotemia, or be azotemic.
What is Creatinine?
Creatinine tests diagnose impaired renal function and measures the amount of creatine phosphate in the blood. Creatine phosphate is used as part of skeletal muscle contraction; its daily production depends on muscle mass. Once creatine is used by the muscles it becomes creatinine and is excreted by the kidneys as BUN.
With normal kidney function, serum creatine levels should remain constant. Only in renal disorders will creatinine be abnormally elevated.
Normal levels
Normal levels of BUN are between 10 to 20 mg/dL for an adult and 5 to 18 mg/dL for a child. Normal creatinine levels are between .5 to 1.1 mg/dL for an adult female and .6 to 1.2 mg/dL for an adult male. Creatinine levels are lower in young children and the elderly as a result of reduced muscle mass.
Creatinine Clearance
Another test that often accompanies creatinine and BUN tests, is creatinine clearance. This test measures the number of milliliters of filtrate made by the kidneys per minute, called GFR. Urine and serum creatinine levels are assessed and the clearance rate is calculated.
Creatinine clearance can help clarify the extent of kidney damage and if one or both kidneys are diseased. As with creatinine, creatinine clearance is slightly lower in children and the elderly. The normal adult male can expect a range between 107 to 139 mL/min and the adult female between 87 to 107 mL/min.
As mentioned, increased creatinine levels can indicate a disease affecting renal function. It can also indicate acromegaly, gigantism or any other disease that would be associated with increased muscle mass, causing normal creatinine levels to be elevated. Decreased levels normally indicate muscle atrophy.
Increased BUN levels can indicate many more pathologies, such as shock, dehydration, congestive heart failure or even starvation. Decreased levels of BUN might be a sign of liver failure or pregnancy.
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Current versions:
DSS DJ 5.6 offers everything the heart of DJ - for cool mixes without expensive equipment.
The discotheque sound system DJ has two virtual turntable, the so-called deck. You can add songs and create smooth transitions between songs. With the crossfader you switch between the two decks back and forth, just like on the real DJ booth. The highlight is the matching function for the number of BPM (beats per minute): with this discotheque sound system DJ adjusts the speed of the songs in the deck creates a perfect mix between the two tracks - DJs with hardware equipment need years of practice to get such transitions. The auto DJ mode you can get started with right - just open the sound files, the discotheque sound system DJ does the rest completely alone. Of course, you can create manual mixes and add effects.
The vinyl simulation ensures real plates feeling: spinning, scratching and re winds (truncate) are no problem for the discotheque sound system DJ. The file formats MP3, M4A, MP4, CDA, OGG, WMA, WAV, AIFF and AU are supported. With the record function, you're taking yours with the discotheque sound system DJ of created mixes and save them in wave format. You can then just burn the mix on a CD. Single - and multichannel sound cards are supported by the discotheque sound system DJ and configured automatically. VST-plug-in the can also be used. Via the MIDI interface you can control even an external hardware mixer.
If you bet the discotheque sound system DJ at a party, you keep the overview by the categorization function: instead of dealing with boxes full of plates or discs, you select relaxed songs from the hard drive. And if it takes you on the dance floor, you can even your computer out of sight: your playlist is protected by password query from the curious guests access. The next party is determined, so you should download discotheque sound system DJ us equal to the best.
The features and benefits of the discotheque sound system DJ in the overview:
• Possible mix automatically or manually
• BPM adjustment function for perfect transitions
• Support all common sound formats - MP3 to OGG
• Vinyl simulation for authentic DJ feel
• Own mixes can wave file will be saved as
You can immediately get started • easy to use - even without prior knowledge
The development of the discotheque sound system DJ
Discotheque sound system DJ, from the Romanian software company Myxoft, was developed in collaboration with DJs from all over the world and won several awards. The goal was to create an easily understandable and intuitive alternative to the expensive DJ equipment. Succeeded: professional disc jockeys also are impressed by the functionality and one dough er friendliness of the software tools, because Myxoft has greatly simplifies their lives. Instead of heavy record crates and equipment for thousands euros, you need only a PC, hard disk or CD with music - and the discotheque sound system DJ.
The current version of DSS DJ can come up with some very useful new features and significantly assist you in implementing your creative ideas. In edit mode, you can see a virtual mixer, which is very clear and structured organized and helps you to cut your favorite songs and create certain phrases. Of course, this is possible also in the so-called loop.
The most important innovations in the current version of DSS DJ
• Cut the songs to infinite pieces
• Audio sources can be played at different speeds
• Integration of playlists from other players
• the preset loops and the effects have been extended


text: Government Extends Exemption On 'No Win No Fee' Agreements For Insolvency Disputes Ministerial Announcement Provides More Time For Insolvency Industry To Adapt 26.02.2015 David Shirt, Press Officer | 0161 838 3094 National law firm Irwin Mitchell has today welcomed the Government's announcement today that the temporary exemption allowing no win no fee agreements for insolvency proceedings will no longer end in April 2015. Originally the exemption from the Legal Aid, Sentencing and Punishment of Offenders (LASPO) Act 2012, was due to end at the end of April 2015, but in a written ministerial statement to Parliament today, Lord Faulks QC has provided insolvency professionals with more time to adapt to changes to civil litigation funding. As a result no win no fee agreements in insolvency proceedings will for the time continue to operate on a pre-LASPO Act basis. This means that the success fee and ATE insurance premium will remain recoverable from the losing party. The Ministry of Justice has said that it will set out further details later in the year. Last year Irwin Mitchell launched a bespoke funding solution which includes a Conditional Fee Agreement and After The Event (ATE) insurance to support insolvency practitioners (IPs) to manage the costs and risks associated with insolvency litigation. The innovative solution, which is called Support4Dispute, has been developed together with leading ATE insurer Allianz Legal Protection, part of Allianz Insurance plc, and will enable insolvency practitioners to pursue litigation following an Administration, liquidation or bankruptcy more easily. Expert OpinionThis announcement is welcome news for insolvency professionals and we look forward to further details in the near future. What it does mean is that combined with our Support4Dispute product, IPs will be able to recover more assets for the benefit of creditors with no financial risk and uncertainty." John Vickery, Partner Key contact John Vickery Partner +44 (0)750 148 7060 Email John Press contact David Shirt BLS PR Manager 0161 838 3094 Email David Tags John Vickery Manchester Related articles 18.07.2017Leeds' Economy Has Grown Faster Than London Since Northern Powerhouse Launch 17.07.2017Manchester's Economy Has Grown Faster Than London's Since Northern Powerhouse 17.07.2017Birmingham's Economy Outperforms London's As It Retain Job Creation UK Top Ten Spot 17.07.2017Cambridge Takes Top Spot In City Economic Growth League Table 17.07.2017Sheffield's Economy Sees Jobs Boost According To New Research


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For years, researchers have studied the relationship between breast cancer and physical activity. Numerous studies have found that physically active women have a lower risk of developing breast cancer than those who don't exercise. This suggests that physical exercise can be beneficial for breast cancer patients. However, researchers from University of North Carolina found that most breast cancer patients fail to meet physical activity guidelines after being diagnosed with the disease.
The US Department of Health and Human Services and the American Cancer Society recommend that adults engage in at least 150 minutes of moderate physical activity or 75 minutes of intense physical activity each week for general health wellness. Researchers took a look at the pre- and post-diagnosis activity levels of 1,735 North Carolinian women aged 20 to 74 years who were diagnosed with invasive breast cancer between 2008 and 2011.
Results found that only 35 percent of the patients met the guidelines for physical activity post-diagnosis. Nearly 60 percent decreased their physical activity six months after diagnosis. African American women, who have a higher mortality rate from breast cancer, were also 40 percent less likely to meet physical activity guidelines compared to white women.
"Medical care providers should discuss the role physical activity plays in improving breast cancer outcomes with their patients, and strategies that may be successful in increasing physical activity among breast cancer patients need to be comprehensively evaluated and implemented," said researcher Brionna Hair, a doctoral candidate in epidemiology at UNC-Chapel Hill.
Breast cancer patients should take precautions when engaging in any physical activity. Some exercises may be too rigorous, especially after breast cancer surgery. Cancer.org has a great list of simple exercises to help restore arm and shoulder movement after breast surgery.
If you or a loved one has breast cancer, follow these steps below to ensure safe exercise:
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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
How do I change the email subject line of my form submissions?Asked by skinstudiogrowth on July 23, 2013 at 03:12 PM
JotForm Support
Hi, in order to change the subject line you need to:
1 - Click on Setup and Embed tab
2 - Email Alerts
3 - Click on the notification from the list.
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Hope it helps!


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|Hercules Sword
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|Iron Sword
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Hercules Sword is one of Strife's weapons in Soulcalibur III. The fabled sword of the great Greek hero Hercules himself. It's said his superhuman strength and unmatched spirit still rest in the blade, bringing glory to each new wielder.
Price: 37,200 Gold at Weapon Shop after Chronicle 7.
Effect: Defense Power Increases, Penetrates Defenses


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|The Lost Chronicles: The Official Companion Book
|The Lost Chronicles: The Official Companion Book
|Mark Cotta Vaz
|September 28, 2005
The Lost Chronicles: The Official Companion Book is a reference guide for Season 1 of LOST and was written by Mark Cotta Vaz and was released on September 28, 2005.
Publisher's SummaryEdit
When Lost debuted on ABC last fall, viewers were immediately captivated. On a remote South Pacific Island, 48 plane crash survivors are forced to scavenge what they can and battle cruel weather and, at times, each other. Some panic. Others pin their hopes on rescue. And some find strength they never knew they had. But the island has many secrets-and hidden dangers-as more than 17 million viewers are discovering.The Lost Chronicles is the must-have guide for those fans. Filled with a detailed episode guide and a behind-the-scenes look at the making of the show, the fully illustrated book offers plot twists and backstories that will help fans uncover the mysteries of Lost.
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text:
How to Put LED lights in miniature dioramas and game terrain
Want to put some electronics into your terrain piece or diorama? LED lights are great. You can use tiny watch batteries, which are small and efficient. LED lights are cheap, they come in colours, and you can find them in all kinds of broken gadgets. Watch this instructional video to illuminate your miniature dioramas, doll houses, and miniature war game terrain.


text: Kraft iFood Assistant Cost: Free or 99 cents for paid version, which includes coupons Kraft's ( KFT) iFood Assistant consists of thousands of recipes that can be searched through by ingredient, meal type or prep time. All recipes come with photos, step-by-step directions, reviews, nutrition info and pairings for drinks and sides. They also all incorporate Kraft products -- a recipe for a Crispy Chicken BLT Salad included Shake N' Bake Extra Crispy Seasoned Coating Mix, Oscar Mayer bacon, Kraft ranch dressing and Kraft natural three cheeses crumbles. The app boasts handy features like directions to the nearest stores with Kraft products. You can add ingredients to your shopping list by scanning the barcode of the ingredient or typing it in by hand to check off items as you shop. While we're a fan of simplicity, we found the recipes in this app a little too basic. We wish Kraft could have incorporated its products -- some of its most beloved brands like Oreos, Miracle Whip, and Ritz --- in a slightly more gourmet and creative fashion to create dishes we actually want to eat.


text:
Just kidding nobody calls me that, I made it up.
Down to earth, humble, kind, adventurous, love to laugh and joke around. I probably won't put a ring on it but if you swipe right we will go on spontaneous roadtrips and random adventures. Im looking for a getaway driver for various crimes aka a partner in crime. Yes...I will buy you tacos.


text: Have stayed in many B&Bs and this was one of the best. The house is beautifully restored (worth going just for that), the room comfortable, Carly was friendly and helpful, and the location on the park and close to everything was fantastic. We got to walk around Anchorage through the waterside park to Sacks (good) for dinner and around the city.


text:
Tangiers Sized Wind Cover! GOLD
This monster wind cover is what everyone's been asking for. Finally a windcover that will fit on top of your KM tray and clear your Tangier's phunnel bowl. 10.5" high and almost 4" in diameter. These remind me of German beer stiens! ***THESE WILL NOT ALWAYS FIT OVER A LARGE TANGIERS BOWL SINCE THEY ARE SO WIDE***
- Type: Hookah Wind Covers


text:
- Imogen Gardner
- 1 years ago
- Views:
1 FIRE & BURN PREVENTION NEWS VOLUME 9, ISSUE 1 SPRING 2013 IN THI S I SSUE Letter from the ABA President Welcome New Committee Chair ABA Partnership Conference IAFF Juvenile Firesetter Project Update American College of Surgeons Focus on Geriatric Trauma/Burn Prevention Frequency of Fireplace Burns Burn Prevention Booth and People s Choice Poster Contest NEW THIS YEAR Friday Educational Forum TGIF (Time to Get Injury Focused): Successfully Incorporating Prevention in Burn Care Palm Springs! AMERICAN BURN ASSOCIATION 45th Annual Meeting April 23-26, 2013 LETTER FROM THE CHAIR Fireplace Burns, Home Remedies & Toxic Chemicals These are just a few of the issues that have confronted the ABA Burn Prevention Committee within the past several months issues significantly more complex than instructing when to Stop, Drop and Roll! Allow me to explain. For over a year, we have been working in partnership with the community education committee of the American Academy of Pediatrics to refute the claims of the Hearth, Patio & Barbeque Association (HPBA) that there are no exceptional burn risks presented to young children by glassfronted gas fireplaces, and that there are only a handful of serious burns treated each year from these devices. As a result, they HPBA propose to appease regulatory standards by including removable protective grills with future products sold that consumers must attach themselves. Here is the problem with that solution: contrary to HPBA s assertion, there are hundreds of these burns treated annually and many of them present serious complications. Dr. Lucy Wibbenmeyer, University of Iowa Burn Center and ABA Burn Prevention Committee member, is giving leadership to an assessment of injury data from participating burn centers to extrapolate the actual number of injuries to toddlers and young children annually from contacting the super-heated glass surface of these gas fireplaces. This data will help us advocate to the U.S. Consumer Products and Safety Commission for a more permanent and comprehensive solution to this hazard. What should one do to relieve pain and promote the healing of a minor burn? You should see some of the home remedies being promoted by one popular web blog! Rather than enter into a debate over the validity of smearing bacon grease on sunburn, the Burn Prevention Committee has created a unit on first aid for burn injuries. Persons who wish an authoritative opinion on treatment options can soon turn to the ABA Website under the Prevention Section to get answers. When is prevention not the best solution? When it is not effective under real-life conditions and its by-products present an even more critical public health threat. Such is the case with certain fire retardant chemicals used in the foam for furniture and bedding. While the Burn Prevention Committee endorses all proven-effective methods of preventing burn injury and reducing the severity of those that do occur, we do not support the infusion of tons of dangerous chemicals, purported to be fire retardants, into furniture foam when there are even more effective, and environmentally friendly fire retardant alternatives. You can learn more about these and many other burn prevention issues by attending the Prevention Track Sessions at the ABA Annual Meeting. Or, better yet, become a member of the Prevention Committee and contribute to solutions to today s burn prevention issues and challenges. Sincerely, Chairman, ABA Burn Prevention Committee
2 Letter from the ABA President Prevention. It is one of the cornerstones of the American Burn Association (ABA). This year the ABA Prevention Committee has been incredibly busy promoting important burn prevention issues by addressing the 5 Ps of prevention: Evidence, Education, Engineering, Enforcement, and Economics. Initiatives have included the development of awareness programs for prevention of scald burns, electrical safety, and gasoline safety; assessment of the incidence of glass front fireplace burns; public policy review for building codes such as the residential sprinkler mandate; and the efficacy of flame retardant chemicals in upholstery, Tina Palmieri, MD, FACS, FCCM just to name a few.. This year our Burn Partnership Conference focused on three important areas of burns: Prevention, Disaster Preparedness, and Burn Survivor Outcomes. We brought together groups from varied backgrounds, including firefighters, burn survivors, the Department of Defense, physicians, nurses, National Fire Protection Agency (NFPA) and members of the Burn Prevention Committee to discuss the current status, develop a list of needs and priorities, and set goals for each of the topics. This incredibly productive conference generated an array of new ideas and partnerships that will help bring all the stakeholders together to work on common problems. The written summary of the Prevention portion of the conference, led by Dan Dillard, has been drafted and will be available for all. Yet the challenge will be to utilize new-found partnerships to convert the goals into meaningful action. We have taken the first step in achieving those goals. As burn providers, our main goal is to ensure the best outcome possible for every burn survivor. As such, prevention yields the best outcome of all: no injury. We need to continue to strive to decrease the incidence of preventable burns by providing information on burn prevention and helping to make prevention a part of every household s daily routine. We have made great strides in burn prevention; our new partnerships have the potential to help us make great leaps forward. Sincerely, Tina L. Palmieri MD, FACS, FCCM President, American Burn Association Karla Klas, RN to Chair Prevention Committee Karla Ahrns Klas, RN, BSN, CCRP, will assume the role of Chair of the ABA Burn Prevention Committee at the conclusion of the 45th ABA Annual Meeting. Klas serves as the Managing Director, Injury Prevention and Community Outreach at the University of Michigan Trauma Burn Center and is the 2013 recipient of the ABA Burn Prevention Award. Karla has distinguished herself as a leading practitioner of evidence-based prevention methodologies, and has served in a leadership role on a number of regional and national burn prevention initiatives, Karla Klas, RN stated Dan Dillard, committee out-going chairman. Her experience, her focus on proven-effective interventions and her strategic vision for a collaborative problem-solving approach to difficult problems make her an excellent choice to chair the Burn Prevention Committee at this time, continued Dillard. AMERICAN BURN ASSOCIATION Burn & Fire Prevention Newsletter Contributors: David Greenhalgh, MD, FACS Karla Klas, RN, BSN, CCRP Annette Matherly, RN, CCRP Tina Palmieri, MD, FACS, FCCM Curtis Ryun, RN Phil Tammaro Kelsey Hartman-Viega Lucy Wibbenmeyer, MD Palm Springs Aerial Tramway 2 AMERICAN BURN ASSOCIATION FIRE & BURN PREVENTION NEWS
3 ABA CONFERENCE SCHEDULE Fire ghter SIG Monday, April 22, :00 am 12:00 pm Mojave Room Renaissance Hotel Burn Epidemiology SIG Monday, April 22, :00 pm 5:00 pm Catalina Room Renaissance Hotel Federation of Burn Foundations Evening Program: Treatment And Prevention: The Therapeutic Lawyer s Active Role Monday, April 22, :00 pm 8:00 pm Pueblo A Room Renaissance Hotel Burn Prevention SIG Tuesday, April 23, :00 am 11:30 am Catalina Room Renaissance Hotel Burn Prevention Workshop Tuesday, April 23, :00 pm 4:00 pm Catalina Room Renaissance Hotel Burn Prevention Symposium Best Use of Prevention Dollars Wednesday, April 24, :30 am 7:45 am Ventura Room Renaissance Hotel Fire ghter Course I: Meth Labs from a First Responders Perspective Wednesday, April 24, :00 am 12:00 pm Mojave Room Renaissance Hotel NEW! Educational Forum TGIF (Time to Get Injury Focused): Successfully Incorporating Prevention in Burn Care Friday, April 26, am 12 pm Primrose B Room Convention Center Raising the Bar on Injury Prevention: A Strategic Approach 10:00-10:10 am Introduction: Taking Responsibility for Prevention 10:10-10:20 am Fire Safety and Burn Prevention Knowledge and Practice Assessment 10:20-10:30 am Burn Epidemiology :30-10:40 am Teachable Moments 10:40-10:50 am Consistent Prevention and Safety Messaging 10:50-11:00 am Prevention Resources and Fact Sheets Best Practices in Burn Prevention: Addressing the Knowledge Gap 11:00-11:20 am Smoke Alarms 11:20-11:40 am Home/Medical Oxygen and Smoking 11:40-11:55 am Forum Panel Discussion and Audience Q&A 11:55-12:00 pm Summary Burn Prevention Symposium Partnering With Your Local Fire ghters Friday, April 26, :15 pm 1:45 pm Sierra Room Renaissance Hotel Burn Prevention Symposium Getting Involved in Burn Prevention Thursday, April 25, :30 am 7:45 am Smoke Tree A Room Convention Center Friday Forum International Outreach Committee Forum: Focus on Burn Prevention in the Developing World Friday, April 26, :00 pm 4:00 pm Primrose B Room Convention Center Correlative VII: Prevention Thursday, April 25, :00 am 12:00 pm Catalina Room Renaissance Hotel Fire ghter Course II: Managing a Mayday Thursday, April 25, :00 am 12:00 pm Mojave Room Renaissance Hotel AMERICAN BURN ASSOCIATION FIRE & BURN PREVENTION NEWS 3
4 People s Choice Poster We received over 20 posters for last years competition and we were very pleased with the interest around the U.S. and Canada for our poster contest. This year we have almost 30 posters from the U.S., Canada and South America and the posters will all be presented at the prevention booth at this year s conference. EDUCATION SESSIONS WITH THE EXPERTS Tuesday, April 23 and Wednesday, April 24 5:30-6:30 p.m. Burn Prevention Booth #713 Flash Over: Movement Patterns of Fire featuring Thomas Flamm Scald Campaign: Scald Prevention featuring Charis Kelly STOP DROP AND ROLL on over to the BURN PREVENTION BOOTH Annette Matherly, RN, CCRN Burn Prevention Booth Hours: Tuesday, April 23 5:00 pm 7:00 pm Wednesday, April 24 9:30 am 7:00 pm Thursday, April 25 9:30 am 2:00 pm The burn prevention booth will be an exciting place to visit at this year s ABA. Not only are we conveniently located by the food and beverages but, for the rst year ever, will be hosting education sessions with the experts on Tuesday and Wednesday evening from 5:30-6:30 pm. Come join us for two intriguing topics, one featuring Thomas Flamm on FIRE MOVEMENT and the other with Charis Kelly on SCALD INJURY. Visitors will have the opportunity to enter a fabulous prize drawing and will also be able to view and vote on the burn prevention posters. Place this booth on your must visit list at this year s ABA meeting. Our team is committed to making your stop worthwhile. 4 AMERICAN BURN ASSOCIATION FIRE & BURN PREVENTION NEWS
5 National Scald Prevention Campaign Update Phase 2 Regional Pilot Tests Observations & Recommendations During Phase 1 of the National Scald Prevention Campaign (NSPC) project, a collaborative steering committee of representatives of the American Burn Association, the Federation of Burn Foundations, the International Association of Fire Fighters Burn Foundation, the International Association of Fire Chiefs and SafeKids Worldwide developed a NSPC Toolkit. This Kit was comprised of a PowerPoint presentation, an Educator s Guide, sample media releases and Scald Burn Fact Sheets. In Phase 2 of the project a Campaign Administrator s Guide was developed, five Pilot Test Areas selected in the U.S., a National Training Session conducted for Pilot Test Teams and the Campaign was implemented in the pilot test areas. An extensive evaluation of the Pilot Test Teams resulted in the following: Pilot Test Area Administrator s Kit was generally well received and contained the basic information needed for successful area/ regional implementation of the program. Program Tool Kit contains a wealth of resource information primarily geared for program administrators/coordinators. Targeted educational products (video, PowerPoint) are needed for specific, targeted risk groups and/or caregivers of these Frequency of Fireplace Burns Lucy Wibbenmeyer, MD, Burn Surgeon, University of Iowa Burn Center Glass fronted fire places (GFGF) are common household appliances often placed on ground level and readily accessible to inquisitive children. Unfortunately, the exterior front glass can reach temperatures of 500 degrees Fahrenheit. 1 Although this temperature is sufficient to cause third degree burns instantaneously, there are no enforced standardized safety features currently in place. 2,3 While single center studies highlight the injuries from GFGF, there is a dearth of national data. Neither the National Electronic Injury Surveillance System (NEISS) operated by the Consumer Products Safety Commission (CPSC) nor the National Burn Repository supported by the American Burn Association (ABA) track these injuries with enough detail to change industry standards. As a result of the lack of injury coding, the CPSC has reduced the number of injuries from 2000 over a ten year review to just 37 injuries. Single center burn studies support much higher injury numbers. In the absence of national injury data, children will continue to present with needless burns from contact with GFGF. In order to determine more precise injury numbers, the Prevention committee of the American Burn Association has initiated a multicenter retrospective study looking at burns to children aged birth to 16 years of age incurred over a three year period. Seventeen burn centers from 13 states and Canada have agreed to share data. These groups (young children, elderly). These products should be geared to the learning capability and style of each group. They should focus on cause, effect and intervention activity. Develop a Campaign slogan or hook for branding and recognition purposes. Media spots must be developed to create a desire for this information among targeted individuals. These should include public awareness ads placed in parenting and senior citizen journals as well as TV and radio spots. Campaign materials should be available for order from a central source. This will create both cost efficiency and standardization of message and branding. Additional promotional/awareness materials need to be developed. These could include, but not be limited to: bus banners; posters; web banners; /text alerts, etc. Phase 3 of the project has now been proposed by the IAFF for funding by a FEMA 2012 Fire Prevention & Safety Grant. If funded, recommendations from Phase 2 will be addressed and the Campaign will be nationally launched. hospitals represent over one-quarter of verified burn centers who admit children and one-half the northern verified burn centers. The Institutional Review Board (IRB) at the University of Iowa has approved the study. The other participating centers are currently obtaining their respective IRB approvals. The anticipated completion of the study will be August of The study is partially supported by a grant from the University of Iowa Injury Prevention Center. Participating burn centers will collect data on injuries related to GFGF contact in order to estimate a more precise incidence of injuries sustained as a result of contact with these appliances. Additionally, the study will describe the types and severity of burns sustained and describes an at-risk population by age or ethnicity. Armed with more true incidence and severity data, the goal of the study is to force industry to mandate standard safety modifications to existing and new GFGF. 1. assessed 9/17/ Moritz AR. Studies of Thermal Injury: III. The Pathology and Pathogenesis of Cutaneous Burns. An Experimental Study. The American Journal of Pathology. Nov 1947;23(6): Moritz AR, Henriques FC. Studies of Thermal Injury: II. The Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns. The American Journal of Pathology. Sep 1947;23(5): AMERICAN BURN ASSOCIATION FIRE & BURN PREVENTION NEWS 5
6 International Association of Fire Fighters (IAFF) Juvenile Firesetter Database PHASE 1 PROJECT UPDATE Phil Tammaro The IAFF JFS Database Project has had excellent progress. To date, we have accomplished the following: Assembled a group of national subject matter experts on December 8 and 9 in Washington, DC. Identi ed and de ned data elements. Reviewed existing databases to evaluate their applicability towards this project. Identi ed stakeholders to participate in a Summit meeting. Conducted a national Summit Meeting in San Antonio, Texas. The results of these meetings and efforts are being compiled into a report that is being prepared for publication shortly. In addition to the written report (which will be distributed electronically), a PowerPoint presentation will be developed and articles will be published in major re safety publications along with Podcasts. Some of the preliminary ndings include: There is a distinct lack of comprehensive, cohesive data regarding the issue of juvenile and individuals involved in working on this a vital part in the success of this project and weaknesses in that none of them are quite Common language is needed among all of leads to the development of a common data An evaluation is needed of the existing data collection methods to determine how a JFS information in the aggregate and for 6 AMERICAN BURN ASSOCIATION FIRE & BURN PREVENTION NEWS
7 2013 ABA Partnership Conference: Focus on Preventing Burn Injuries Over 150 members of the ABA and invited representatives of kindred organizations participated in the 1st Annual ABA Partnership Conference on February 12, 2013, in Washington, D.C. The Conference was organized to collaboratively address three key strategic focus areas of the ABA: Priorities and Strategies for Preventing the Burn Injury; Optimizing Long Term Quality of Life; and Managing the Mass Casualty Burn Incident. Conferees participated in three separate sessions, the first and third of which were joint sessions. Session 1 entailed introductory presentations by specialist on each of the focus areas. Presenters for the Prevention Focus Area included Dan Dillard, Chair of the ABA Prevention Committee; Jason Woods, representing firefighters viewpoint; and Judy Comoletti of the NFPA. Each speaker identified current assets and deliverables and also enumerated the needs and challenges still requiring attention. During Session 2, conferees participated in facilitated group discussions for each of the three focus areas. Potential objectives and action items were identified and prioritized by each group. In Session 3, the priorities and recommended actions developed in session 2 were shared with all conferees. The Prevention Group forwarded three priority objectives and two immediate action items for ABA Board of Trustees consideration. A white paper will soon be published itemizing the proceedings and recommendations emanating from the Partnership Conference. Furthermore, the ABA Board of Trustees will convene later this year to address these concerns as it undertakes the creation of an ABA Strategic Plan. The Conference, in Washington D.C., was organized to collaboratively address three key strategic focus areas of the ABA: Priorities and Strategies for Preventing the Burn Injury; Optimizing Long Term Quality of Life; and Managing the Mass Casualty Burn Incident. AMERICAN BURN ASSOCIATION FIRE & BURN PREVENTION NEWS 7
8 The ABA and the Committee on Trauma of the American College of Surgeons Focus on Geriatric Trauma/Burn Prevention David G. Greenhalgh, MD, FACS The population is now shifting to be dominated by the elderly. The birth rate is down in developed countries and healthy living along with better health care is allowing people to live longer. The United States Census predicts that the percentage of elderly will continue to expand in the future. In 2010, 24% of the U.S. population was greater than 55 years and 13% were over 65 years. They predict that in 2050 almost a third (31.1%) will be over 55 years, 20.2% over 65 years and 4.3% over 85 years. Clearly, the incidence of trauma and burns will increase in the elderly population. It is essential that prevention efforts should focus on the elderly. As the representative of the ABA to the Committee on Trauma (COT) of the American College of Surgeons, I am fortunate to be on the COT s Prevention Committee. In cooperation with Dr. Deborah Kuhls, MD, FACS, who is the Chair of the COT Prevention Committee, we are focusing on geriatric Burn Prevention. Clearly, there are different types of injury associated with trauma than burns. Trauma prevention for the geriatric population focuses on prevention against such injuries as falls and motor vehicle accidents. Burns tends to focus on fire safety, especially related to cooking and starting fires for brush, smoking, and scald prevention. There are some common themes, however, that can allow for some common prevention efforts. As people age they tend to lose strength, endurance and reaction times. A person may have climbed a ladder to empty the gutters for years but as they get older, their balance may worsen so they are more prone to falling off the ladder. Along the same light, an elderly man may have burned his leaves with gasoline for years but as age slows his reflexes he may not be able to avoid the flame and then set his clothes on fire. In a similar fashion, an aged woman may have cooked all of her life but the one time her loosefitting clothes touch a flame she may not be able to extinguish the flames. Altered balance in the shower may lead to falls that, if associated with too high a water temperature may lead to both fractures and burns. As neurologic function declines, confusion may also lead to problems. Dementia may lead to poor decision making that can lead to both trauma and burns. Unfortunately, we have seen all of these types of injuries. While we could usually handle the injury or burn as a younger person, as we age we lose the ability to tolerate even minor injuries. The elderly person with a fracture may never be able to ambulate well again. The small burn often leads to loss of independence and transfer to a skilled nursing facility. The saddest issue is that since the ability to prevent larger burns or trauma may lead to an unexpected death. It is not uncommon that even minor injuries become the start of the decline in the geriatric population. Our combined efforts to prevent these injuries will allow the elderly to survive even longer and viable lives. The ABA Prevention Committee The Burn Prevention Committee is charged by the American Burn Association (ABA) to provide leadership in the area of burn prevention; gather and disseminate information related to burn awareness, prevention, and survival; assist in the development of burn prevention programs on the local, regional, national and international levels; and to serve as a resource to members and af liated organizations in the eld of burn prevention. Members of the Committee are selected and appointed by the President of the ABA from within its general membership. They are credentialed as burn care support professionals, public safety professionals, education specialists and corporate and non-pro t managers. The focus of the committee s work is in North America. 8 AMERICAN BURN ASSOCIATION FIRE & BURN PREVENTION NEWS
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text:
My Notes:
The Guthrie combines the designer's touch that makes your home memorable with the smart design that will help you save as much as 30% on your energy bills. On the first floor, you'll enjoy a raised serving bar and a kitchen that opens to the family room. The second floor is especially lovely, with an optional fifth bedroom or game room. Generous walk-in closets in the bedrooms will provide the storage space you need. The laundry room is close to the master bedroom for very easy access. Lots of enjoyment awaits you in this home that has a space for it all! Call today for more information!