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A developer of business management software.Speak with a Clarisys provider
Our Business
Accounting software is our business, and it always has been. Since 1983, we have focused our resources on product development, training and support. Unique in their design, our suite of integrated accounting packages is fully compatible, multi-lingual, and simple to learn and to use.
A Long-term Relationship
Our goal is to establish a long-lasting business relationship with each of our clients. To help us achieve this goal we are committed to providing small businesses around the world with high-quality accounting software.
We know how difficult it can be to start and manage a business. If we can save a new business some money by providing them with the opportunity of using one of our packages free of charge, we are happy to do so.
We are confident that the quality of our products will meet or exceed our clients' expectations and that the depth and consistency of our product line will ensure that as their information processing needs grow, our clients will purchase a more powerful or specialized program within the Clarisys family.
The Right Choice
Our development team is continuously creating new and innovative products. In this ever-changing market, our products are constantly evolving to incorporate ever more powerful features while maintaining their simplicity of use.
At Clarisys we believe we are the right choice for companies in search of accounting software that will meet their needs for years to come. Give us a try, we know you will agree.
Product Lines
Executive Accounting
An accounting software system designed by Clarisys.
Powerpak Accounting and Inventory Control
A inventory application designed by Clarisys.
Market Focus
Evaluations of Clarisys products by market segment:
Get Software Recommendations
For over 15 years, independent software experts have helped more than 200,000 businesses find the right software for their needs. We'd love to help you, too.


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Through 7/2, Target has a hot deal on Purex Laundry Detergent. The big 150 oz bottles are on sale for $6.99, plus you will get a $5 Target Gift Card when you buy two. Toss in some coupons to get an even better deal. Here's the scenario:
At Target:
BUY TWO PUREX LIQUID LAUNDRY DETERGENT 150 OZ 100 LOAD, on sale $6.99
Get a $5 Target Gift Card when you buy two select Purex Detergent 100-150 oz
Use one $3/2 Purex Laundry Detergent 128 oz or larger printable coupon
or use two $1/1 Purex Laundry Detergent 128 oz or larger printable coupons
Price at Register: As low as $10.98, but get $5 Target Gift Card
NET PRICE FOR ALL: $5.98 (or $2.99 per bottle!)
Thanks Totally Target.Extreme Couponing Tip: You can usually get two prints of most internet coupons. To find them in the easiest possible way, use our preclipped links that take you right to the coupon. Then come back and click the same link to get your 2nd print. This will save you the time spent searching for the coupon.
Never miss another hot coupon, deal or freebie again! "Like" Couponaholic .NET on Facebook, Follow us on Pinterest, Follow us on Twitter, Follow us on Instagram or Subscribe to our Daily Email Newsletter!

subset: commoncrawl


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Someone asked me recently how to configure NSX Load Balancing to get a single virtual IP (VIP) with multiple ports. Indeed, applications often listen on multiple ports and to avoid creating multiple virtual servers for that, you can define VIPs that are based on a port range. Reminder: NSX load … [Read more...]
Force HA Failover on NSX Edges
When NSX 6.2.3 was released earlier this year, a sentence in the release notes about failover caught my attention. NSX Edge — On Demand Failover: Enables users to initiate on-demand failover when needed. Well, since that moment, NSX 6.2.3 has been replaced by NSX 6.2.4 (sort of), but this … [Read more...]
Inspect your network with vRealize Network Insight (vRNI)
VMware vRealize Network Insight 3.0.0 (formerly known as Arkin) is now generally available. vRNI delivers intelligent operations for software-defined networking and security, with converged visibility across virtual and physical networks, planning and recommendations for micro-segmentation and … [Read more...]
Configuring NSX Edge Services in Async Mode via API
I was reading through the NSX API Guide recently and a section caught my attention: Configuring Edge Services in Async Mode. When configuring edge services asynchronously, accepted commands return an Accepted status (HTTP response status code 202) and a jobId (or taskId). The advantage of the … [Read more...]
Get Log Insight for free with NSX 6.2.3+
VMware released NSX for vSphere 6.2.3 last week: although considered as a minor release, NSX 6.2.3 brings a lot of enhancements. We also released Log Insight 3.3.2 at the same moment. The big news is that you get now Log Insight for free if you are entitled to NSX...yes, for free! :) The … [Read more...]
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Hover on image to zoom
Beat the heat in style by teaming this polo tee with a pair of shorts and loafers. You can also match it with a pair of chinos and sneakers for a smart casual look.
Enter your PIN code to check the delivery time and special services


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L.J. Smith, TE Rutgers
Height: 6-2 Weight: 258 40-time: 4.75
Career notes: All-Big East Conference second-team
Served as team captain... Ranks second in school history among tight
ends with 122 receptions for 1458 yards (12.0 avg) and ten touchdowns.
Positives: Durable athlete with good quickness,
agility and balance, displaying adequate strength
Has no trouble releasing
from the line, showing quickness getting into his blocks
Displays good
concentration going up for the ball, making proper body adjustments and using
his body to shield the ball from the defenders
Instinctive runner with
a good feel for the zone's seams.
Negatives: Has to build to reach his top speed and
lacks the acceleration to be effective on deep routes
Not a polished route
runner, needing to do a better job of selling his routes
Has good, but
not explosive separation agility
Does not show ideal leaping ability
good hands, but tends to double catch and cradle the ball.


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The deal
1x 8-day SIM card for $82 (rrp. $198)
2x 8-day SIM card for $158 (rrp. $396)
1x 15-day SIM card for $129 (rrp. $288)
2x 15-day SIM card for $239 (rrp. $576)
Product specifications and features
- Carrier network: Docomo
- Supports 4G LTE
- No registration needed
- Valid for 8 or 15 days
- Expiry date: Sep 30, 2016
- Supports maximum downloading speed of 150Mbps
- One-off use. No value adding allowed
- Comes with Nano SIM (Micro SIM adapter included)
- Does not support phone calls or SMS
- The largest network that covers the whole of Japan
- Speed: 4G LTE for first 200MB; 200kbps unlimited data access subsequently (auto-resets at 12am daily)
- Compatible with most iPhone and Android smartphones and tablets
- Supports Internet access and connectivity (emails, Youtube, Facebook, Google, Twitter, etc.)
- Supports Google Map
- Supports apps for chatting (WhatsApp / LINE / Kakao)
- Supports Internet calls (Skype / LINE / Viber / Kakao)
- Supports Wi-Fi Sharing with other devices
- Does not support HTC, Xiaomi, Lenovo, Blackberry, and non-original smartphones, please contact merchant for more details
Customers are advised to read the 'APN Setting' leaflet before use
Not available for dual-sim mobile phones, HTC, Blackberry, and China-brand mobile phones such as Xiaomi, Lenovo, and non-original smartphones
Daily Charge starts upon the successful activation of the sim. Daily Charge is levied on a daily basis. There is no pro-rata calculation of Daily Charge. A day means 00:00 to 23:59 (Japan time) wherever a customer is and the cut-off time is 23:59 (Japan time) each night wherever a customer is. If the SIM is activated during the daily cut-off time, it will be counted as one day when it reaches 00:00 and another day will be counted afterwards


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The Leading eBooks Store Online
3,935,953 members ⚫ 1,292,914 ebooks
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Distinguished ServiceMarquette University Press 2006; US$ 45.00
Walter J. Kohler, Jr. was one of Wisconsin's best governors. Elected three times, he played a role in the election of Dwight D. Eisenhower to the presidency in 1952 and was known to be an administration favorite. Kohler's challenge was to unite moderate Republicans, who backed Ike, with a Far Right that fervently supported Senator Joe McCarthy.... more...
Conducting Educational Design ResearchTaylor and Francis 2013; US$ 59.95
Educational design research blends scientific investigation with systematic development and implementation of solutions to educational problems. Empirical investigation is conducted in real learning settings-not laboratories-to craft usable and effective solutions. At the same time, the research is carefully structured to produce theoretical understanding... more...
A Guide to Authentic e-LearningTaylor and Francis 2009; US$ 47.95
Part of the groundbreaking Connecting with e-Learning series, A Guide to Authentic e-Learning provides effective, working examples to engage learners with authentic tasks in online settings. As technology continues to open up possibilities for innovative and effective teaching and learning opportunities, students and teachers are no longer content... more...
MOOCs and Open Education Around the WorldTaylor and Francis 2015; US$ 39.95
As new digital forms of formal and informal learning proliferate, there is an increasing need to better understand how people in different regions of the world are implementing massive open online courses (MOOCs) and other forms of open educational resources (OERs). Educators, researchers, politicians, and numerous other stakeholders want to grasp... more...
Structural Biology of Membrane ProteinsRoyal Society of Chemistry 2007; US$ 232.00
The book provides up-to-date reference source for researchers. Introductory sections to each topic are followed by detailed discussions for the experienced biochemist. more...
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Veterans Day Sale Mixed Case
Your Veterans Day Sale Mixed Case includes one bottle each of
Albarrada Red
Albarrada is a new and exclusive winery that makes amazing wine that showcases local grapes. This red wine (or vinho tinto, in Portuguese) features a local grape, called Castelão. Native to the soils of Portugal, Castelão. It is unusual, finding a better home in the drier and harsher climate of Portugal than the normally more grape friendly soils of temperate climates. When well cared for, the wine that results is aromatic and fruit-forward with notes of red berries and slight hints of floral notes.
Spencer Family Reserve Cask Red
Fill up your cart with this deliciously smooth, robust red. Sweet black fruit aromas added to layers of ripe black cherry and plum flavors reflect a heavenly marriage of Cabernet Sauvignon, Grenache and Syrah. Forward fruit flavors and a velvety texture make this a go-to red wine for every day enjoyment.
Rivers End Reserve Merlot
A wonderful wine from the River's End winemakers with ripe berry fruit flavors and aromas with a nice touch of oak. An amazingly versatile choice for serving with grilled duck, turkey, chicken, braised lamb, pork or beef – and a nice partner for dishes featuring a rich tomato sauce.
Saddlehorn Zinfandel
Nothing suits a hearty beef roast, baked Portobello mushrooms or a filet mignon topped with a tasty blue cheese sauce, like this muscular, yet restrained Zinfandel. It showcases the essence of blackberry bramble and raspberry jam balanced by a thread of licorice, leather, cedar and exotic spice.
Della Flora Red Toscana Rosso
Tuscany produces stunning Sangiovese blends. These wines have medium weight, easy finish, and intriguing flavor profiles. These wines are enjoyable as a cocktail sippers, but when pairing with foods, any dish that has fatty meats and fresh tomatoes bring out the very best in flavors from these wines. Della Flora Toscana Rosso has fresh raspberry and strawberry flavors with hints of roasted peppers and fresh herbs like thyme. You will pick up some native earthy flavors like clay from these wines as its unique characteristic only further enhance the smooth drinking experience you get from Tuscan reds. Some of our favorite pairings are hearty Spaghetti Bolognese with shaved parmesan and pork and sausage stuffed red bell peppers.
Buscado Garnacha
Grenache is a varietal grown around the world and in the country of Spain, it goes by the name Garnacha. Each country where Grenache is grown, it expresses the unique terroir and shows different flavor profiles. For Spain and specifically the grapes in Buscado, Garnacha produces intense and pleasant aromas of licorice and wild berries with slight mineral undertones. Flavors of ripe red fruit, fresh thyme and hints of minerals linger on the finish of this silky and full-bodied expression of Garnacha.
Allegro Riesling
Refreshingly crisp and slightly sweet, Allegro Riesling offers swoon-worthy aromas and flavors of peach, pear, nectarine, lychee and clove – all perfectly sealed with a kiss of bright acidity. Their grapes are sourced from the finest Monterey vineyards and cold tank fermented in stainless steel to promote the vivid flavors, elegant palate weight and lively finish that make this wine an engaging complement to fresh fruit, artisan cheese and Asian dishes. Talk about love at first sip!
Hayton Family Reserve Chardonnay
It has a refreshing "say no to oak" style – bright and light with citrus, apple and tropical fruit aromas and flavors. A gentle acidity adds structure while allowing the delicate fruit flavors to shine. Versatile and food-friendly, it makes a good choice with seafood, poultry, or pasta dishes with butter-based sauces.
Kiyapura Sauvignon Blanc
A clean, citrusy, lean and fresh wine. The nose is full of grapefruit and green apple, followed by zesty flavors of green fruits, lime, floral notes, and a long, crisp finish. Outstanding as an aperitif or a cocktail wine, it is also ideal with salads using arugula, fennel, or roasted bell peppers, and is a refreshing companion for richer white meats like pork and lobster.
Bayshore Vintners Pinot Grigio
This lovely wine from Bayshore is produced from one of the first vineyards in California planted with Pinot Grigio that originally focused on dessert wines. That is until a wine importer, seeing the potential for table wines, used these grapes to launch a line of food-friendly table wines. Gorgeous aromas jump out of the glass and delicious flavors of melon, citrus and tangerine are completed by a refreshing thread of crisp acidity.
Porta De Ravessa White Wine Blend
Porta Da Ravessa is a white blend of Roupeiro, Fernao Pires and Arinto varieties. With these grapes Porta Da Ravessa has fruity and floral aromas that lead into rich, dry flavors citrus and stone fruit with vibrant acidity and a clean finish.
Moon Crest Sauvignon Blanc
Fresh and zesty with aromas of melon, freshly cut grass, green apple, sweet citrus zest and fig, this wine has a brisk acidity that carries its fruit and herbal flavors through a refreshing finish. Serve with fresh goat cheese, seafood or vegetarian dishes.


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This is an extremely useful spell for long-duration fights. It has a quick cast time and a 2 second cooldown. The damage it does to an enemy is almost nonexistant so its primary purpose is healing.
It places a debuff on an enemy target that does a damage/healing ping roughly once every 3 seconds. For every healing ping recieved by the Necromancer an additional temporary stacking buff is activated; future health pings from a Mark of the Devourer are boosted by 10%. The buff lasts for approximately 10 seconds and is restarted with an additional stack when more health pings are recieved. Because this spell has a quick casting and cooldown time it would not be difficult to have multiple Marks active on several enemies. Only one mark can be active on an enemy at a time. If the mark is able to go for its entire 25+ second duration, the Necromancer will recieve a final large burst-heal over five times as strong as a regular health ping.


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Hi guys
Just joined the forum.
Been using iOS for 5 years, decided to sell my iPhone 5 and I'm getting an android phone.
Truth is, I'm doing it to confirm which one suits me best, so I'm giving it a try.
I hope to learn a lot here since I know nothing about Android
Thanks in advance


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To sustain you talk terms a do mart price tag for a home, it's most advantageous to get an sorting and study buzz. Even if you hold direct with the environment marketer on a mart price, you may poverty these items to precaution the plus point of your new asset.
To hire a executive inspector, association the American Home Inspectors Directory (AHID). The American Home Inspector Directory includes inspectors from all political unit agreed household examiner organizations. Including the American Society of Home Inspectors (ASHI), National Association of Home Inspectors (NAHI), or National Association of Property Inspectors (NAPI). A certified evaluator checks a address for:
Structural components. This includes the foundation, floors, walls, columns, ceilings and protection.
Home outside. This includes doors, windows, chimneys, decks, balconies, steps, voidance and road.Post ads:
domain info
domain info
Plumbing. This includes pipes, sinks, drains, and bathroom fixtures.
Electrical regulations. This includes electric wiring and foundation equipment, electrical phenomenon and emf ratings, electrical device quarrier and light fixtures.
Heating and chilling systems. This includes boilers, thermostats, fry pumps, insulation, air conditioning, main controls, fans, ducts and filters.Post ads:
domain info
domain info
An enquiry tale may shun provision of paint, wallpaper, carpeting, house appliances and draperies. These are unanimously replaced by the buyer, whose tastes are possible deviating. You may too impoverishment a special examination for pests, or for dirt and drain. Inspections commonly expenditure involving $250 and $500.
An judgment is about e'er hunted once you buy a nest. However, if you dispute with the appraisal value, you can always command your own estimation. You can brainstorm an valuator through with such organizations as the National Association of Master Appraisers (NAMA). Appraisals mostly disbursement linking $250 and $500.
Negotiating a marketing asking price routinely starts with you production an first bestow on the home. The introductory give is normally smaller quantity than the seller's address list terms.The trader can accept, wash your hands of or treat your initial proposal. He can also spawn a counter-offer. A counter-offer is a contract to demean the fee to run into your propose at lowest possible part-way.
After the primary counter-offer, the customer and vender may go through with a ordination of counter-offers to arrive at a dutch auction terms (if agreeing at all). This means the spread, or gap, involving information bank price tag and first set aside gets narrower. Armed with your own opinion and scrutiny report, you can brand an au fait proffer and much efficaciously talk terms a concluding merchandising asking price.
Article submitted by the American Home Inspector Directory


text: A type of pizza made with vegetables, well seasoned and topped with cheese. Start a Discussion Discussions about Lakruar Lakruar A FANDOM user This is not a pizza. It made with FILO dough and features leeks,eggs and sometimes lamb. 2014-01-03T17:26:10Z See more discussions > Retrieved from "http://recipes.wikia.com/wiki/Lakruar?oldid=477255" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Albanian Food Glossary Add category Cancel Save


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Black Strappy Satin Evening Sandals
$24.49 $57
A caged vamp, t-strap and covered heel really show off the lustrous satin finish of these sexy pumps. Covered satin heel. Shoe sole measures 0.75 inches thick. Shoe heel measures 5 inches high from back top of heel to sole.
• Satin upper.
• Adjustable buckle ankle strap.
• Satin covered platform is .75 inches thick.
• Man Made Materials
• Imported
Product Code: F00406/F00406


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Currently 1.00/512345 Rating: 1.0/5 (Total votes: 2)
Rating: 1.0/5 (Total votes: 2)
· Breaking news, top stories, US, world, politics, health, entertainment news and more
· Snack-sized highlights or full stories
· Local news, weather and traffic
· Sharing via e-mail, SMS, Twitter and Facebook
Breaking News Alerts:
· Find out immediately when news breaks
· Breaking news alerts pushed to your home screen
· Live breaking news video
· Top video from all categories, most popular and the best of CNN TV
· Optimized for your connection
Local News, Weather and Traffic:
· Location-based news headlines
· Current weather conditions, 10-day forecasts and radar maps
· Traffic maps and incident reports
CNN iReport:
· Contribute to CNN's coverage on stories that are important to you
· View, record and submit video and photo iReports directly from your phone
What's New in This Release:
· America's Choice 2012 Election Center for iPhone now available.
· General bug fixes and enhancements.
What's New in 1.2.3:
· Now optimized for iOS 5.
What's New in 1.2.2:
· Fixed image caching issue
What's New in 1.2.1:
· UI improvements for Live TV
· Minor stability enhancements
What's New in 1.1.2:
· An improved Twitter experience
· Minor bug fixes
» show more


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All-Out-Of Pad
Don't you just hate it when you've gone to the market, carried in a ton of groceries, put them away, only to have someone ask, "Why didn't you buy any cereal? We're all out!." With this pad everyone can keep track of what they've yused the last of, so you don't have any more "Why didn't you get's."


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Retain a Law Firm that Provides Client-centered Representation
We have extensive experience protecting the rights and interests of individuals and families in San Diego County. We understand that clients don't want to hear excuses — they want results, and that is the reason clients turn to us for quality service, sound advice and practical legal help at a reasonable price.
We have proudly earned our reputation one client at a time. We focus on the goals of the client and work hard to achieve those goals with the most streamlined approach possible. Contact us today for a consultation.
Contact Griffith, Young & Lass today if you need legal assistance with any of the following:
Child Support
- Child Support Enforcement
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Custody & Visitation
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- Legal Custody
- Physical Custody
- Sole Custody
Call Griffith, Young & Lass today at 855-338-4379 to arrange your free initial consultation.
Attorney Profile
Attorney John Griffith
- California
Legal Certification:
- Certified Family Law Specialist by the California Board of Legal Specialization
- San Diego at Thomas Jefferson School of Law, J.D.
- Georgia State University, 2003
Professional Memberships and Achievements:
- San Diego Bar Association—Family Law
- North County Bar Association—Family Law
- Association of Certified Family Law Specialists
- North County Family Law Specialists Group


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Bella Voce Singers is a women's choir based in Brooklyn, New York. The choir gives numerous concerts throughout the year, including regularly scheduled performances in the Park Slope and Bay Ridge neighborhoods of Brooklyn.
The choir originated as an all-female teen group when Founding Director Jessica Corbin was teaching at New York City's F. H. La Guardia High School of Music and Art and Performing Arts. When Jessica left La Guardia in 2001, the choir followed her to Brooklyn, where they continued to grow and perform, eventually being named one of the top high-school age choirs in New York City and performing with the Orchestra of St. Luke's at Carnegie Hall. As the Bella Voce members began to graduate and move on to college, many decided that they still wanted to sing together, so the choir expanded to include all women ages 18 and up.
Bella Voce is now a 45-member multigenerational group dedicated to excellence in choral singing. Our mission is to enrich and educate our members and our audiences by performing a diverse repertoire with an emphasis on contemporary choral composers such as Gwyneth Walker, Elizabeth Alexander, Clifton J. Noble, Jr, Joan Szymko, Eleanor Daley, and Abbie Betinis, and by bringing other new and lesser-known works to the community. We have performed with many choirs including the New York Treble Singers, the Davidson Singers, Damkoren SALT (from Sweden), and Coro Musa (from Japan), and we are a regular participant in the bi-annual New York Women and Girls' Choir Festival. Bella Voce Singers has released two CDs: Songs of Peace and Love (2011) and Hope (2014). You can purchase CDs on our website (coming soon).
The choir rehearses on Monday nights from 7–9 pm at Greenwood Baptist Church in Park Slope, Brooklyn. Bella Voce Singers auditions new members twice a year.
Jessica Corbin, Artistic Director
Jessica Corbin is in her 15th season as Artistic Director of the Bella Voce Singers. A graduate of Indiana University and Duquesne University, Jessica currently works as a freelance conductor, music director, vocal coach and accompanist in and around New York City, and is an adjunct professor at Marymount Manhattan College, in the Music Theater Department. She has extensive teaching experience, having served as an Associate Instructor in the Music Theory Department at Indiana University, Director of Musical Activities at the Maryland School for the Blind, teacher in the vocal music department at F. H. La Guardia High School of Music and Art and Performing Arts in Manhattan, a teacher of piano, chorus and theory at the Brooklyn Conservatory of Music, and in the Theater Department of Kingsborough Community College of the CUNY. She most recently composed all original music for The Visitors, a short musical-play produced by EnGarde Arts in the BOSSS Festival in Manhattan. As an accompanist and music director, she regularly works with area theater programs and vocal classes, including those at New York University, Marymount Manhattan College, Kingsborough Community College, and the Workshop Theater Company in Manhattan. She also works as a vocal coach in Manhattan and Brooklyn, and for the past four years has been faculty as vocal coach and accompanist at the Kennedy Center American College Theater Festival.
Melanie Cozzi, Assistant Director
Melanie Cozzi is a classically trained vocalist and music education specialist that grew up in Staten Island, NY. She has received her B.M. in Voice Performance from The Hartt School at the University of Hartford, her M.M. in Voice Performance and Advanced Certificate in Music Education from CUNY Brooklyn College. Melanie has been the assistant director for BVS since 2007. During that time, she has regularly conducted community performances with the group, such as Make Music New York, and was the artistic director of BK Teens. She currently teaches at the International School of Brooklyn and Greene Hill School, and resides with her husband in Bay Ridge, Brooklyn.
Sergio Sandí, Accompanist
Sergio's bio is coming soon.


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Memu Movie Review and Rating, Memu Review, Memu Rating, Surya Memu Movie Rating:
Surya Latest Family Entertainer Memu Releasing on 08 July 2016. This is dubbed Movie of Tamil version Haiku( Pasanga 2). This is the sequel movie to Pasanga. This movie not released in telugu. Memu Movie is the children's movie. Amala paul doing female leading role in this movie Memu. After commercial action movie 24 Surya coming with this family entertainer. this is the good change to surya fan audience.Memu movie review and rating.
Banner : Sri Manikanta Creations
Movie : Memu (Telugu)
Cast : Suriya,Amala Paul,Bindhu Madhavi,
Directed by : Pandira
Produced by : Surya
Memu Movie Rating:*/5.0
Memu Review and Rating, Story, Talk, Live updates
Memu Movie "Review":
Memu Movie Starring by Suriya,Amala Paul,Bindhu Madhavi. This movie Directed by Pandira. Surya Producing this movie under the banner of 2D Entertainment Pasanga Productions. Music given by Arrol Corelli.
Pasanga 2 is a heartwarming film that deals with children suffering from Attention Deficit Hyperactivity Disorder (ADHD). The story in which these children get shaped forms the major crux of the movie. The problems which arise as a result of their attention deficit has been also discussed by the director.It is the little kids who are going to win your heart. Main leads are being done by many child actors and there is a good importance to Suriya's character. Suriya will be seen as a teacher in this children's drama movie and an interesting thing is he will be appearing for 40 minutes in this movie.


text: To get from Floridia to Gioia Tauro by train you can catch one of the 1 trains that everyday travel between these two cities. The first train to Gioia Tauro leaves from Floridia at 07:10 and the last train departs at 07:10. If you choose a local train the trip lasts on average 05:30 hours. For your trip from Floridia to Gioia Tauro by train you can choose to leave from one of Floridia main stations: Targia On Wanderio you can compare all schedules, fares and railway companies to Gioia Tauro and book the best itinerary starting from Floridia.


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Guy Martin Proper
Guy Martin Nigel Racing Corporation Head Gasket ® Bobble Hat and DVD Bundle Deal!
Guy Martin Nigel Racing Corporation Head Gasket ® Bobble Hat and DVD Bundle Deal!
Choose either a Blu-ray of Last Flight of the Vulcan, Complete Speed or a DVD of Our Guy in India or How Britain Worked! Save £5!
Would you believe it..Nigel the dog has come up with this hat, as a nod to Guy racing this year! He's a bright lad alright and NRC are happy to have Guy's new team on board.
Designed by Guy and Nigel, well Nigel and Guy.
Shipping to the United Kingdom using Royal Mail 48. Please allow up to 9 days for delivery.
Pre Order products, please allow 9 working days from the release date.
Allow longer for International orders. In the unlikely event that you have not received your order within 9 days of the order date, please do notify us.
If you have an issue with an order you have placed and want to return the goods for a refund or exchange, please contact us within 14 days via phone or email.


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When I see beams of sunlight illuminate shimmering rain, I feel warm inside.
I love to share with people the experience of newly created musical sound.
I am involved with Art, Music, Writing and Holistic Arts. My meditation music mostly I write with piano , chanting and a range of instruments. My alternative music involves blues/rock guitar, piano, vocals and backing instruments. -
From time to time I hold Sound Circle workshops in the South west of WA. I bring a range in instruments where people can explore their inner voice to create meditation music and sounds. No experience required.-
Contact me for live performance and workshop bookings : details. Joe ; email@example.com -
http://soundcloud.com/savaggio -
http://www.triplejunearthed.com/Artists/View.aspx?artistid=46693 -
http://www.redbubble.com/people/savaggio -
http://www.gumtree.com.au/s-ad/winnejup/other-real-estate/rare-earth-tree-gully-sanctuary-expressions-of-interest/1004566529 -
Workshop Facilitator
Self Development Gatherings including; Team build projects, Sound health workshops, Nurture your birth right.
An introduction to Sound Healing with : 'Sound Circle Dreaming' (TM)
Vocalist and Sound artist; Joe Savage invites you to a gathering with some interesting and unusual instruments: Chimes, Rain sticks, Drums, and more. You are invited to explore with your voice and your body's instinctual rhythm. The aim is to have fun and find relaxation and maybe create some unique meditation music. Along the way we may find a place of 'non-thinkin' and 'energetic' spaces that inherently open doors to health and clearing.
All ages are welcome and musical experience is fine but not essential.
Other platforms for this gathering are; Intermediate and Experienced.
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Real Estate Law
Have Real Estate Law Questions? Ask a Real Estate Lawyer.
Thank you for your prompt reply.
Just to clarify, if they service both mortgages (first and second), do they have the right (or ability) to work on both "accounts" at once? What i mean is, can they promise to release alll rights on the second while they are actually still pursuing the first? I hope the question makes sense
Thank again for you reply. How often do they attempt to collect on second mortgages after a foreclosure. I am able, at the moment, to qualify for a Chapter 7, so I can do so now (after getting a credit hit for a frecl;osure and all that goes with it, it seems insignificant), it seems beneficial to do so now........ if they can come after me in 5 years and stretch the credit hit for much longer. But if they do so in rare occasions, it may seem like a risk to take....you thoughts?


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Modeling of Wheat Imbibition and Germination as Influenced by Soil Physical Properties
- A. Bouaziz and
- L. Bruckler
A theoretical model that was used previously for predicting maize (Zea mays L.) seed imbibition, and subsequently, germination, is applied to wheat (Triticum aestivum L.) seeds. The proposed model takes into account the seed-soil water movements in both liquid and vapor phases under nonlimiting aeration conditions. The main variables that govern the imbibition process are (i) the seed-soil water potential difference, (ii) the seed contact area as affected by vapor or liquid transfers, and (iii) conductive properties of the seed for both liquid and vapor phases. Laboratory experiments show that (i) the imbibition process occurs both in liquid and vapor phases, (ii) wheat seed must reach a critical moisture content before germination (0.27 kg kg−1 approximately), and (iii) the rate of the imbibition depends upon the seed surface area affected by liquid or vapor transfers and on the water potential of the external medium that governs the ability of the seed to reach its critical moisture content. The proposed model is regarded as satisfactory after calibration of the seed conductive properties in liquid and vapor phases. Field experiments involved irrigated and nonirrigated treatments (31.7% clay, 42.5% loam, 25.8% sand) and manual or mechanical sowing. Moisture content, bulk density profiles, and soil porosity analyses were used to estimate the seed-soil contact area. The previous imbibition model was applied to field experiments, combining field data with the laboratory results. This model accurately predicted wheat imbibition and germination. Finally, simulated results compared the effects of climatic conditions and sowing techniques on wheat germination for three climatic sequences. Climate was the major limiting factor illustrating the importance of selecting the suitable sowing techniques to optimize the seed imbibition and germination processes.Please view the pdf by using the Full Text (PDF) link under 'View' to the left.
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I ride my racer bike I create textiles I can cook Iam clean I mind my own business and I always pay my bills on time
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Easy peasy walk to town, Lismore Base Hospital, TAFE, sports grounds, shopping and CBD area. Cheap, safe and affordable accommodation. Rooms are semi furnished, and there is an on-site manager. Other residents are workers and students - there's a good mix from different backgrounds. THERE ARE A RANGE OF ROOMS - FROM SINGLE ($140), SHARED/ FEMALE ONLY DORM ($115/PERSON) TO DOUBLE ($190 - $210) PER WEEK - ENQUIRE ABOUT WHAT IS FREE OR COMING UP! There are a choice of room style depending on availability - some larger than others with a sunroom-style and fan. The kitchen is good - shared fridges, gas stove, microwave etc and a cupboard for your food. There is also a laundry and the games room has a table tennis and weights , and the lounge area has TV, heating and dining area. Wifi included in room rates We have a weekly cleaner for the shared areas, and there is a friendly manager on-site to keep things ticking over. We also have a games room with table tennis.
In town, close to everything ! Safe affordable and friendly place . This is a very popular room - single bed with good light and ventilation. Private and quiet. The house has shared bathrooms, fully equipped kitchen, TV room, games room, huge backyard. Do you own thing, or team up with others. Walk to everything in town, or if you have transport, you can easily explore the whole region - Nimbin, Byron Bay, Ballina etc from here - without paying the huge coastal rents. We have on site managers.
A great room in the Lismore guesthouse! Room 8 is a tidy double bedroom, with plenty of light and air. Quiet and clean and super affordable! NB - this is one week minimum rental! And sorry - we cannot take pets! This room is part of the Estreet Guesthouse, Lismore's best short term accommodation. If you are new to town, between places or traveling then this is the place to be! Shared bathrooms (3), laundry and kitchen are all available for your use. The rate includes power, gas and wifi - as well a weekly linen change. The house is huge - it was Lismore's first maternity hospital! There is a huge shady backyard, outside deck, TV room and a games room. We also have on-site management. House rules make this a really safe, friendly and affordable place to stay. We are situated within easy walking distance to everything in Lismore - shopping, Hospital, services and entertainment. Interested? Ask now about availability !
Cute , self contained all newly built , this small room with separate kitchen , covered deck , bathroom and view is minutes from CBD and a short drive or walk to the hospital and University .It has its own entrance and a tiny garden can be established just off the deck .. Out of flood zone too! Would suit an employed person or serious student who is smoke , drug and alcohol free
Simple cosy home surrounded by greenery.. the kind of place where you can fool yourself into thinking you're in the country
I'm a social young guy looking for a place in the Lismore/surrounding area, I've lived here pretty much all of my life. I study at Tafe but in my own time I like to make music and do most things creative, I also love to cook and would be quite happy to cook for others :)
I'm a chilled, considerate and quietly sociable gay guy. I like good, nourishing food and am up for having the occasional meal together. I've been in Lismore for two months from WA and absolutely love it here. I'm well educated and reasonably well travelled and I like people.
Single mum with a 6 year old daughter, looking to possibly team up with a 1 other person. or another Single parent and child. Flexible with areas between Lismore to Ballina. Hopefully bigger house with lots of room. or a house with separate living areas. If this sounds suitable please message me for more details. Clean and tidy and easy going not a party person.
Hello there, My name is Dalida. I am German and have planned to take a little time out. Starting off my three months sabbatical, I will be staying in Lismore for the whole of October to work at the FoK as a volunteer. Therefore, I would need a room/ place to stay for this period of time. I am reliable, honest, helpful, friendly and open-minded person. I would be very happy to receive replies from nice and friendly people who have a bright, nice and clean and quite accommodation to offer. Looking forward to hearing from you.:-) Dalida
Student. Casual worker. More than the sum of the parts. I have widely varied musical tastes (whilst respecting volume levels) and enjoy getting amongst it, wether that be hiking to the top of the mountain or snorkeling to find nemo. I cook a mean roast or BBQ, I cook a sub par risitto but an working on that. I cannot walk tight rope, nor juggle. I do have a mean as frisbee and hackysack game though. I am a conscientious and empathethic flatmate. I have no pets but I love animals. I rarely party but when I do you better hope you have a camera handy.
Easy going Tidy Keep to ourselves
Hello Me and my Partner are in urgent need of accomadation We are both currently receiving Centrelink my partner is studying, and I am also looking for work. We are both Friendly, Respectful Clean & quiet and tend to keep to ourselves :)
I have a partner, i smoke outside, i dont drink or do drugs. im honest,relyable, im easy to get along with, easy going,helpful,im caring, an im a strong believer in karma an treating others how id want to be treated and fun.
Easy going person and happy to meet new people. Would love to join a place that has a family type environment. I love spending time with people and alone, I understand the balance people need. Flexible in what my flatmates like to do from drinking and partying to just hanging out and chilling. Whatever is fine. People within 10 years of my age would be perfect. either looking to move up the coast to the Byron Bay Area or inner city and/or around Bondi or Northern Beaches areas.


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Monday, December 1, 2008
Semiconductor Sales Drop
The worldwide financial crisis is starting to hurt the semiconductor industry, according to the latest report from the Semiconductor Industry Association. The SIA said today that worldwide semiconductor sales dropped by 2.4 percent in October, down to $22.5 billion in sales versus 2007 sales of $23.0 billion. The SIA said the October drop in sales continues a trend that first became evident in September. The group said it expects the financial turmoil to continue to impact demand for semiconductors in 2009, saying that it a 5 percent decline in PC unit shipments, and 9 percent drop in cell phone unit shipments next year.


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Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study
Cell and molecular biology
The identification of circulating tumour cells (CTCs) in peripheral blood is a useful approach to estimate prognosis, monitor disease progression, and measure treatment effects in various malignancies. However, clinical relevance of CTCs is controversial. We attempted to detect viable CTCs in the peripheral blood of gastric cancer patients using a telomerase-specific viral agent.
We took a 7.5-ml blood sample from 65 treatment-negative gastric cancer patients before surgery and 10 healthy volunteers. We detected viable CTCs in the blood samples after incubating them with a telomerase-specific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein (GFP) gene (OBP-401). GFP-positive CTCs were defined as having a diameter of at least 7.735 μm; this threshold was determined by receiver operating characteristic curve analysis. GFP-positive cells were counted under a fluorescence microscope.
There was a significant difference in overall survival among the patients with 0–4 and those with ≥5 GFP-positive CTCs in the stage I–IV disease group and stage II–IV advanced disease group. The number of GFP-positive CTCs was not related to cancer stage. Among the pathological findings, the number of GFP-positive CTCs was only significantly related to venous invasion, although there were trends towards more GFP-positive CTCs with disease progression (tumour depth, lymph node metastasis, distant metastasis, lymphatic invasion, and histological type).
There was a significant relationship between the number of GFP-positive CTCs and overall survival in the patients with gastric cancer. The detection of CTCs using OBP-401 may be useful for prognostic evaluation.
Trial registration
University Hospital Medical Information Network in Japan, UMIN000002018.
Distant metastasis of a solid tumour is a strong prognostic factor
Cell enrichment by density gradient separation is performed using commercial kits such as OncoQuick® (Greiner, Frickenhausen, Germany)
Immunomagnetic cell enrichment, such as that performed by the CellSearch System® (Veridex, LLC, Raritan, NJ, USA)
Telomerase plays important roles in carcinogenesis, cancer invasion, and metastasis
Here, we applied the assay to detect viable CTCs with the potential for metastasis in gastric cancer patients. We detected GFP-positive CTCs. In contrast, it is possible that non-cancer cells emit GFP fluorescence after OBP-401 infection
Patients and healthy volunteers
The patients included in this preliminary study were those undergoing planned surgical treatment; patients who were suitable for endoscopic mucosal resection or endoscopic submucosal dissection were excluded. The inclusion criteria were: (i) histologically proven adenocarcinoma of the stomach by endoscopic biopsy; (ii) clinical solitary tumour; (iii) no prior endoscopic resection, chemotherapy, or radiotherapy; (iv) age 20–80 years; (v) Eastern Cooperative Oncology Group performance status
All the patients attended our hospital regularly after surgery, and were checked every 3 months. The patients also underwent endoscopy and computed tomography at least once a year, according to their disease stage and course.
We also recruited healthy volunteers to act as controls. All healthy volunteers were employees of Sysmex Corporation and included seven men (mean age 31.4 years, range 24–39 years) and three women (mean age 33.7 years, range 26–48 years). All volunteers underwent medical check-ups upon employment and annually; check-ups included medical interviews, auscultation, chest radiographs, and blood and urine analyses. Furthermore, we performed individual interviews before sample collection; any volunteer who was currently receiving medical treatment, pregnant or breastfeeding, or who had donated blood within the past month was excluded.
OBP-401, a telomerase-specific, replication-selective adenoviral agent in which the
Cell lines and culture
The A549 (lung carcinoma), HepG2 (hepatocellular carcinoma), HEC-1 (endometrial adenocarcinoma), KATO-III (gastric carcinoma), and SBC-3 (small cell lung carcinoma) cell lines were obtained from the Health Science Research Resources Bank (Osaka, Japan). The LNCaP (prostate adenocarcinoma) and OVCAR-3 (ovarian carcinoma) cell lines were obtained from the Riken Cell Bank (Tokyo, Japan). The cells were cultured according to the vendor's specifications. MDA-MB-468 cells were cultured as previously described
Sample preparation and cell counting
A 7.5-ml peripheral vein blood sample was obtained from each patient before surgery and from each volunteer. The samples were drawn into tubes containing citric acid, phosphoric acid, and dextrose, and stored at 4°C. The assay was started within 48 h.
The samples were centrifuged for 5 min at 540 g and the plasma phase was removed. The cells were then washed four times with phosphate-buffered saline (PBS) and twice with Roswell Park Memorial Institute medium. The samples were infected with 4 × 108 plaque-forming units (PFU) of OBP-401 viruses by incubation in the medium for 24 hours at 37°C.
After dead cell staining by the red-fluorescent reactive dye L23102 (Life Technologies Corporation, Carlsbad, CA, USA), OBP-401 viruses were inactivated and cells were fixed with 2% paraformaldehyde (PFA) for 20 min at room temperature.
The samples were treated with a surface-active agent (Emalgen 2025 G; Kao Chemicals, Tokyo, Japan) for 10 min at 40°C to degrade red blood cells. Finally, 7.5 ml blood was used to create two glass slide samples for microscopic analysis. All GFP-positive cells on the two slides were counted, using a computer-controlled fluorescent microscope (IX71; Olympus, Tokyo, Japan) and an examiner blinded to the sample details. The total assay time was 27.5 h (Figure
Figure 1
Protocol and procedure of the "GFP-CTC Assay"
Protocol and procedure of the "GFP-CTC Assay". Each 7.5-ml peripheral vein blood sample was obtained from patients before surgery and from volunteers. The samples were drawn into tubes containing citric acid, phosphoric acid and dextrose. The samples were centrifuged and the plasma phase was removed. After cell washing using PBS and Roswell Park Memorial Institute medium, the samples were infected with 4 × 108 PFU of OBP-401 virus. OBP-401 virus was inactivated and cells were fixed with 2% paraformaldehyde (PFA). The samples were treated with a surface-active agent to degrade red and white blood cells. Two glass slide samples from 7.5 ml blood were prepared for microscopic analysis. All GFP-positive cells on the two slides were counted using a computer-controlled fluorescent microscope.
Determination of GFP fluorescence intensity threshold
The threshold for GFP fluorescence intensity was determined as follows. Approximately 30,000 cultured cells were spiked into 7.5-ml blood samples from healthy volunteers, which were spiked with various cancer cell lines: A549, HepG2, HEC-1, KATO-III, SBC-3, LNCaP, MDA-MB-MB468 and OVCAR-3. Blood samples were subjected to CTC detection assay, and then detectable cells were counted by fluorescence microscopy. More than 100 cells were analysed in each sample. We determined 2.85 × 107 mean equivalent fluorochrome to be the threshold for GFP signal intensity from the minimal GFP intensity level observed in the blood samples spiked with the cell lines (Figure
Figure 2
GFP signal intensities from various cancer cell lines
GFP signal intensities from various cancer cell lines. The bottom and top of the box are the lower and upper quartiles, and the band of the box is the median. The lines on the end of the whiskers are minimum and maximum. The y axis represents GFP signal intensity on a log scale.
Phycoerythrin-labelled anti-human CD45 antibody (BioLegend, San Diego, CA, USA) was diluted 1:5 and Pacific Blue-labelled anti-human CD326 (EpCAM) antibody (BioLegend) was diluted 1:10 in PBS containing 2% foetal bovine serum. Cells were incubated with diluted antibodies for 30 min at 25°C. After washing with PBS containing 2% foetal bovine serum, cells were mounted on glass slides and analysed using a fluorescence microscope (IX71; Olympus).
Statistical analysis
Statistical analysis was performed using JMP Statistical Discovery 9.0.2 (SAS Institute, Cary, NC, USA). To determine the cell diameter threshold, the detected GFP-positive CTCs were analysed using a receiver operating characteristic (ROC) curve between the samples from gastric cancer patients and those from volunteers. For multiple group comparisons, homogeneity of variance was assessed by the Levene test. For parametric comparisons we used analysis of variance, and for non-parametric comparisons we used the Wilcoxon and the Kruskal–Wallis tests. We used Fisher's exact and
The study was approved by the Institutional Review Board of the Showa University, Northern Yokohama Hospital. We explained the study protocol to the patients and volunteers before they gave written informed consent. This study was registered with the University Hospital Medical Information Network in Japan, number 000002018.
Participant characteristics
Sixty-five patients with gastric adenocarcinoma (46 men and 19 women; mean age 58.8 years, range 33–76 years) who underwent surgery at the Digestive Disease Center of the Showa University Northern Yokohama Hospital between September 2009 and May 2011 were included in this study. Twenty-nine had distal gastrectomy, 32 had total gastrectomy, and four had exploratory laparotomy. The patients' characteristics are summarised in Table
GFP-positive CTCs in peripheral blood
Using a fluorescence microscope, cells with fluorescent emissions ≥2.85 × 107 mean equivalent fluorochrome were counted as GFP-positive cells.
Various sizes of GFP-positive cells were observed in each sample; therefore, it was difficult to identify one representative cell among the GFP-positive cells for comparison between patients and healthy volunteers. Therefore, to avoid using an arbitrary value, we decided to use the optimum threshold derived from the ROC analysis based on the cell size, that is, 7.735 μm, as the threshold to define GFP-positive CTCs (Figure
Figure 3
Comparison of cell diameter between patients and volunteers
Comparison of cell diameter between patients and volunteers. To determine the threshold, we compared the diameters of cells from gastric cancer patients and controls by ROC analysis. There was a significant difference between the gastric cancer patients and the controls (
By immunohistochemical staining using anti-EpCAM and anti-CD45 antibodies, we confirmed that GFP-positive CTCs were EpCAM-positive and CD45-negative (Figure
Figure 4
Examples of microscopic images
Examples of microscopic images. Representative images from two gastric cancer samples of GFP-positive CTCs and immunocytochemical analysis of anti-EpCAM- and anti-CD45-positive cells. Cells were counted using a computer-controlled fluorescence microscope by an examiner blinded to the sample status. Scale bar, 10 μm.
The numbers of GFP-positive CTCs in the peripheral blood samples are shown in Figure
Figure 5
Number of GFP-positive cells
Number of GFP-positive cells. The dots are the numbers of GFP-positive CTCs in the patient samples. The bottom and top of the box represent the lower and upper quartiles, and the band across the box shows the median. The lower and upper bars at the ends of the whiskers show the lowest data point within 1.5 interquartile ranges of the lower quartile, and the highest data point within 1.5 interquartile ranges of the upper quartile, respectively. The green bars indicate mean value.
Association of GFP-positive CTCs with survival
The mean number of GFP-positive CTCs in the samples from 10 healthy volunteers was 4.8. We divided the patients into two groups based on the numbers of GFP-positive CTCs: 0–4 and ≥5. The clinicopathological characteristics of the two groups are summarised in Table
Figure 6
Overall survival
Overall survival. (a) Overall survival of all patients. (b) Overall survival of patients with stage II–IV disease. Survival was compared according to the number of CTCs using Kaplan–Meier analysis and the log-rank statistics. **
Association of GFP-positive CTCs with pathological indices
There was no significant relationship between the number of GFP-positive CTCs and cancer stage (
Figure 7
Relationship between number of GFP-positive CTCs in a 7.5-ml blood sample from gastric cancer patients and pathological findings in the patients
Relationship between number of GFP-positive CTCs in a 7.5-ml blood sample from gastric cancer patients and pathological findings in the patients. The dots are the numbers of GFP-positive CTCs in the patient samples. The bottom and top of the box represent the lower and upper quartiles, and the band across the box shows the median. The lower and upper bars at the ends of the whiskers show the lowest data point within 1.5 interquartile ranges of the lower quartile, and the highest data point within 1.5 interquartile ranges of the upper quartile, respectively. a, Tumour invasion depth (T1–T4 indicate increasing depth). b, Lymphatic metastasis (N0 = negative, N1–3 = positive). c, Distant metastasis (M0 = negative, M1 = positive). d, Histological type (differentiated type and undifferentiated type). e, Lymphatic invasion (L0 = negative, L1 = positive). f, Venous invasion (V0 = negative, V1 = positive), *
This paper reports the correlation between CTCs and gastric cancer, which is the second leading cause of cancer-related death worldwide. The usefulness of the detection of CTCs in the diagnosis, estimation of prognosis, and evaluation of treatment effects has already been reported for breast
One major outcome of our study was a significant relationship between the number of CTCs and prognosis. Although we used a short follow-up period, the prognosis of patients who had ≥5 CTCs in their 7.5-ml peripheral blood samples was poor. Patients with early stage disease generally have a lower recurrence rate
Among our pathological findings, only venous invasion had a significant relationship with the number of CTCs. This suggests agreement between traditional pathology and modern molecular technology. We believe that the lack of a significant difference between the number of CTCs detected by our assay and the other pathological indices can be explained by methodological issues such as the small sample size. Our technique worked well as a prognostic evaluation tool — to provide information about the need for postoperative adjuvant therapy — and it may provide a useful auxiliary tool to pathology-based classification.
It is not clear whether all detected CTCs have metastatic potential. Viable CTCs were detected in the samples from early-stage cancer patients in the present study, but almost all stage I group patients survived without recurrence
Our results must be interpreted with some caution, considering the limitations of this study. First, the number of CTCs varied widely between individuals, including patients and healthy volunteers. Moreover, it was not influenced by tumour stage or the presence of clinically detectable metastases. Similarly, there was no association between the presence of metastases (lymph node or distant) or invasion and the number of CTCs, which brings into question the use of CTCs to predict metastatic potential. However, it is possible that the relatively small sample size limited the potential to detect real differences between these groups of patients. Finally, it must be acknowledged that our results are only applicable to preoperative, treatment-naïve gastric cancer and should not be generalised to other types of cancer.
Clearly, more studies in a larger population of patients, and with different cancer types, are needed to clarify the clinical applicability of CTC detection. We are now preparing a study to investigate the effects of gastric cancer treatment on the number of CTCs, which should help to establish their relationship with future disease progression and whether CTC count can help guidetherapy choice.
There was a significant difference in survival between patients with 0–4 CTCs and those with ≥5. However, it is unclear whether all CTCs have true metastatic potential, and further studies are needed.
Competing interests
No competing interests declared.
Authors' contributions
HI (Ito) conceived and designed the experiments, collected blood samples, performed the experiments, delivered clinical patients' data, and performed the statistical analysis and interpretation of data. HI (Inoue) participated in the study design and performed interpretation of data. NS participated in the study design and performed interpretation of data. SK (Kimura) participated in the study design, maintained the equipment, including the test tubes, and performed data interpretation. KG, JS and KM performed the experiments and interpretation of data. SI performed the statistical analysis and interpretation of data. NO and HS managed clinical examination and performed treatment of individual patients. SK (Kudo) participated in the study design and coordination. All authors have read and approved the final manuscript.
This research was supported in part by a Grant-in-Aid for Challenging Exploratory Research (23659308) from the Japan Society for the Promotion of Science (JSPS). The funding body played no role in the study design; in the collection, analysis, or interpretation of the data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. We are grateful to all the patients and volunteers who donated blood to this study. We would like to thank Professor Toshiyoshi Fujiwara (Okayama University Graduate School of Medicine, Okayama, Japan) for providing helpful comments and suggestions; Mr Yasuo Urata (Oncolys BioPharma, Tokyo, Japan) for supplying the OBP-401; Dr Yukio Tsujino, Dr Toshiyuki Ozawa and Dr Akinori Masago (Sysmex Corporation, Kobe, Japan) for their helpful support; and Dr Rebecca Devon (Genetics Unit and University of Edinburgh, Edinburgh, UK) for critical review and editing of the manuscript. We are also most grateful to clinical staff.
Lymph node metastasis as a prognostic factor in laryngeal cancer
Incidence and prognosis of para-aortic lymph node metastasis in gastric cancer
Incidence of lymph node metastasis and its impact on long-term prognosis in clinically localized prostate cancer
Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
The hallmarks of cancer
Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer
Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells
Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device
In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry
Detection and quantification of circulating tumor cells in patients with esophageal cancer by real-time polymerase chain reaction
Squamous cell carcinoma-antigen messenger RNA level in peripheral blood predicts recurrence after resection in patients with esophageal squamous cell carcinoma
Isolation of rare circulating tumour cells in cancer patients by microchip technology
Detection of circulating tumor cells in blood using an optimized density gradient centrifugation
Circulating tumor cells in the peripheral blood and bone marrow of patients with ovarian carcinoma do not predict prognosis
Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells
Reverse transcription-polymerase chain reaction detection of prostate-specific antigen, prostate-specific membrane antigen, and prostate stem cell antigen in one milliliter of peripheral blood: value for the staging of prostate cancer
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the Cell Search system
Circulating tumor cells in peripheral blood samples from patients with increased serum prostate specific antigen: initial results in early prostate cancer
Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial
Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy
Telomere states and cell fates
Specific association of human telomerase activity with immortal cells and cancer
Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses
Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy
A simple biological imaging system for detecting viable human circulating tumor cells
A novel approach using telomerase-specific replication-selective adenovirus for detection of circulating tumor cells in breast cancer patients
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
Portable filter-based microdevice for detection and characterization of circulating tumor cells
3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood
Toxicity and response criteria of the Eastern Cooperative Oncology Group
Circulating tumor cells, disease progression, and survival in metastatic breast cancer
Circulating tumor cells predict survival in patients with metastatic prostate cancer
Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer
Detection and evaluation of epithelial cells in the blood of colon cancer patients using RT-PCR
Clinical significance of circulating tumor cells in blood from patients with gastrointestinal cancers
Early gastric cancer: univariate and multivariate analysis for survival
High levels of DNA index heterogeneity in advanced breast carcinomas. Evidence for DNA ploidy differences between lymphatic and hematogenous metastases
Tumor vascularization, mitotic index, histopathologic grade, and DNA ploidy in the assessment of 114 head and neck squamous cell carcinomas
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Bungalow 5 Baluster Lamp in Pink
$ 537.00
The Baluster Lamp in soft white high - fire porcelain is a classic form of neutral color. The design features an antiqued silver - leaf base and silvered ball finial. Available in white, pink and light blue. Shade sold separately. Lamp only.
- Glazed Porcelain
- Silver Cord and Silver Leaf Base
- Color: Pink
- Overall: 9.5" w x 9.5" d x 28" h


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Sebra Baby Rattle Deer
Baby Rattle designed by Sebra, hand crocheted and with a delightful bell sound
14,95 € *
You receive 15 °P for this product
Description of Sebra Baby Rattle Deer
A small deer for the little ones!
Irresistible and adorable, this handmade deer rattle has little bells that gently ring as your little one plays with it. It is perfect for a baby´s tiny hands and will easily become baby´s best friend.
- rattle with ring
- with small bells inside
- handmade
Sebra products impress with their loving and cheerful designs, natural materials and ancient handcrafted techniques, such as crochet and knitting, etc. The Sebra Collection was created with a lot of dedication, and designed and implemented by parents for parents and their children.
The little Deer is a wonderful baby rattle that rings and also captures our hearts!
Art-No.: 521-3071Measures: Length 7.5 cm, Width 5 cm, Height 13 cm, Diameter 10 cm
Weight: 0.03 kg
Category: Games & Fun
Brand: Sebra
Color: brown
Material: wood; 100% cotton
Product Certification:
Sebra Baby Rattle Deer Reviews
Be the first to write a review for this product!


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Revel Barker, the tireless archivist of Fleet Street memories (many of which may be true), points out that too many journalists are too lazy to write obituaries about their long-time friends and colleagues.
"Understand this," he tells his readers on gentleman.ranters.com, "when you snuff it, nobody will care enough about you to write about you.
"They might have thought kindly of you in the past, and may well be saddened by your passing; they may attend your funeral or write their name on the list at the memorial service. But they won't bother enough to write a piece."
So he is asking for do-it-yourself obits to ensure that people who are elevated to what he calls the Great Editorial Floor In The Sky are properly remembered.
"Send it in and I'll file it somewhere safe... Tell somebody close to you to be sure to drop a quick email to Ranters... when you fall off the twig. We'll run the obit – obviously without revealing that you'd written it yourself. And everybody will be delighted with its insight and accuracy."
He offers some guidance before concluding: "Who ever gets the opportunity to read their own obituary? If you write it yourself you can read it as often as you like."


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Tasty Bite� 1 Step - 1 Minute� Kashmir Spinach�. Indian cuisine. All natural. Microwavable pouch. Heats in 1 minute. Lightly saut�ed spinach with cubes of paneer cheese. Vegetarian. Kosher inspection service certified
Spinach, Water, Tomatoes, Paneer Cheese, Onions, Sunflower Oil, Garlic, Salt, Ginger, Chilies, Cumin.
1 step heating instructions. Microwave. Cut pouch 2" to vent and heat on high for 1 minute (ovens may vary). Heats in 1 minute. Stovetop. Boil sealed pouch in water for 5 minutes. Serve as is, with Tasty Bite� rice or with flatbread! Use caution, grab pouch from sides, pouch will be hot. Refrigerate unused portion. Do not use conventional or toaster oven. Do not consume if pouch is leaking or swollen.
Always refer to the actual package for the most accurate information


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by Staff Writers
Tokyo (AFP) Oct 04, 2013
Japan's atomic watchdog summoned the boss of Fukushima operator TEPCO on Friday for a public dressing-down over sloppy standards at the crippled nuclear plant, as yet another problem with radiation-polluted water emerged.
The Nuclear Regulation Authority (NRA) called in Tokyo Electric Power Co president Naomi Hirose and other executives over "the inappropriate management of contaminated water".
"The problems have been caused by a lack of basic checks," NRA secretary general Katsuhiko Ikeda told Hirose.
"I can't help but say that standards of on-site management are extremely low at Fukushima Daiichi," Ikeda said. He added the utility should strengthen its staffing levels, including by sending workers from other nuclear plants.
Hirose apologised to Ikeda and pledged to increase efforts to deal with the ongoing problems "by using all the company's resources, including people, equipment and money".
The meeting came as it was revealed that a key system to decontaminate radioactive water at the plant had stopped again.
TEPCO said it halted the Advanced Liquid Processing System (ALPS) -- the only one of three that was in operation -- early Friday following "an alert suggesting abnormality in the process".
The firm said the cause of the problem was not known, but no leaks of radioactive water from the system had been detected. It was restarted in the evening, the company said.
The stoppage came just four days after TEPCO got the system back up and running following a breakdown when a piece of plastic clogged the machine.
ALPS is the great hope for TEPCO, which is struggling to cope with a huge -- and growing -- volume of liquid at the plant, where overheating reactors had to be cooled with thousands of tonnes of water after a tsunami hit in March 2011.
They continue to be doused, more than two-and-a-half years after the disaster.
Without a functioning ALPS, TEPCO is dependent on only one separate decontamination system to begin processing about 1,000 tanks full of water.
Independent experts have said that ultimately this water will have to be dumped in the ocean once it has been scoured of the worst of its radioactive contamination.
But neighbouring countries, global pressure groups and local fishermen are deeply opposed to the idea, unmoved by assurances that the radiation will be massively diluted as it mixes with the vast Pacific.
Friday's stoppage is the latest in a growing list of setbacks at the plant, where TEPCO's haphazard and uncoordinated efforts to fix the mess have been derided by one government minister as akin to someone playing "whack-a-mole".
On Thursday the company announced 430 litres of polluted water had spilt from a tank as workers tried to remove rainwater dumped at the plant during a recent typhoon.
Its admission that the "contaminated water may well have flowed into the sea" came after the firm announced in August that 300 tonnes of toxic water that had leaked from a different tank had made its way into the ocean.
The UN atomic agency said Friday it was sending experts to Japan on October 14 for a week-long review of progress on the clean up.
After some time in Fukushima and meetings with government officials, the International Atomic Energy Agency will publish a report on its findings.
While the tsunami cost more than 18,000 lives, the nuclear disaster it caused is not officially recorded as having directly killed anyone.
But tens of thousands of people who were evacuated are still unable to return to their homes, with scientists warning some areas near the plant will have to be abandoned forever because of radioactive contamination.
Last week TEPCO applied to the Japanese watchdog for permission to restart two reactors at a different plant.
All of Japan's 50 working reactors are offline amid public scepticism over nuclear power.
Related Links
Nuclear Power News - Nuclear Science, Nuclear Technology
Powering The World in the 21st Century at Energy-Daily.com
|The content herein, unless otherwise known to be public domain, are Copyright 1995-2014 - Space Media Network. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA Portal Reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement,agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement


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Independent Producer Survey: Technology, Services, & Other Drivers of Carrier Choice - L/H Edition
Independent Insurance Producers Uninspired by Carrier Offerings Insurance Reports Published by Celent
1,602 independent producers provide unique insights into how they select one carrier over another, and what it takes for a carrier to become a producer favorite.
Despite massive commitments of energy and budget by carriers seeking to strengthen their independent sales channels, most independent producers have relatively few favorite carriers and spread their new business across three carriers or more.
"Producers would gladly settle on a favorite, if only carriers would differentiate themselves by addressing the things that producers really care about," says senior analyst Craig Weber, author of Celent's latest report, Independent Producer Survey: Technology, Services, & Other Drivers of Carrier Choice (available in Life/Health and Property/Casualty editions). "But the vast majority of carriers dont give independent producers the right suite of products, services, and technology to meet their needs," Weber adds. "The result is that distribution investments are often wasted.
The report describes how product price, features, and underwriting speed are typically table stakes enough to put carriers in the running for a piece of new business, but not enough to differentiate the carrier and give producers a reason to concentrate their business with that carrier. (See Figure 1 above.)
"From a question about key drivers of carrier choice, it did not appear that technology was a major factor," says Weber. "But then we asked producers to name a favorite carrier and the reason for their choice. The results suggest that technology can be a key differentiator if it improves producers day-to-day quality of life. Producers who name favorites tend to be enthusiastic about their choice."
Survey respondents named The Hartford as a clear favorite in both Life/Health and Property/Casualty segments. Other favorites included Zurich, Travelers, AIG/Lexington, and Chubb Group for Property/Casualty, and Prudential, Pacific Life, and John Hancock for Life/Health.
Other key features of the report include:
- Detailed breakdowns of technology available to agents in the field and how often that technology is used.
- Insights into producer views on technology initiatives such as electronic signatures, online learning, tele-underwriting, and more.
- An examination of how producers from different segments typically handle both new sales and servicing transactions.
- A discussion of new business cycle time and how producers think it affects not-taken rates.
The reports are based on a Celent survey administered to 1,602 independent producers in August, 2003. A table of contents for both reports is available online. Click here for the life/health edition, here for the property/casualty edition.
of Celent Communications' Life/Health Insurance and Property/Casualty Insurance research services can download the report electronically by clicking on the icon to the left. Non-members should contact email@example.com for more information.
Celent is a research and advisory firm dedicated to helping financial institutions formulate comprehensive business and technology strategies. Celent publishes reports identifying trends and best practices in financial services technology and conducts consulting engagements for financial institutions looking to use technology to enhance existing business processes or launch new business strategies. With a team of internationally based analysts, Celent is uniquely positioned to offer strategic advice and market insights on a global basis. Celent is a member of the Oliver Wyman Group, which is a wholly-owned operating unit of Marsh & McLennan Companies [NYSE: MMC].
Media Contacts
North America
Michele Pace
Tel: +1 212 345 1366
Europe (London)
Chris Williams
Tel: +44 (0)782 448 3336
Asia (Tokyo)
Yumi Nagaoka
Tel.: +81 3 3500 3023
Table of Contents
|Boston, MA, USA November 11, 2003
Independent Producer Survey Life/Health Edition
Return to report Abstract


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Free Download MOD APK Android Yummy Gummy | Only best games at Sbenny.com
Game Description:
Treat hungry yummies to gushing gummies! Come set sail in an all new puzzle adventure to Yummy Gummy Land. Made with a juicy twist, this unique match-3 game serves up just the right amount of fun and challenge in every level.
Swipe sugary sweets by joining candies into chains for your fruity friends to fill their jelly bellies. Float through cotton candy clouds and over the rainbow river as you explore the luscious lands. Match your way to sweet victory!
★ Unlimited gameplay with hundreds of juicy levels
★ Sweet moves make delicious combos
★ Fruity friends float on when they're full
★ Achievements keep you playing longer
Connect With Facebook to get lives, watch leaderboards and share game savedata!
Game Requirements and Details:
Android Version Required: 2.3.3 and higher versions of Android Smartphones and Tablets
Required Storage Space: 57 MB or more
Internet connection NOT required to play
APK ID: com.zindagigames.yummygummy
Game Version: 2.7.0
Genre: Puzzle
Price: Free with In-App Purchases
Ads? YES
Installation Instructions:
- Download one of the [APK] files below (MOD version is the HACKED game) or try the [Google Play] version;
- Move the .apk game file to your Android Smartphone or Tablet and install it (if you are on mobile, just install the apk tapping on it);
- Launch the game and have fun with Yummy Gummy!
Free Download Yummy Gummy APK Android
Broken Link? Outdated Version? Report it! Want us to make a custom MOD for you? Visit our dedicated Forum!
[APK] [59.5 MB] [v2.7.0] [MEGA MOD]
MEGA MOD Features:
- Unlimited Coins
- Infinite Lives
- 99 Moves
[APK] [60.1 MB] [v2.2.7] [MEGA MOD]
MEGA MOD Features:
- Unlimited Lives
- Unlimited Coins
[APK+DATA] [Google Play] [Free Game]
Have troubles installing Yummy Gummy? Please read our Forum guide about HOW TO INSTALL ANDROID GAMES AND APPS.
Link broken? Looking for a newer or MOD (hacked) version of Yummy Gummy? Join our community and we will help you!


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Clemson Easter Bunny Run 5k & Half Marathon Volunteer Registration
Adventure Geek Productions
Saturday, March 30, 2013 from 1:00 PM to 4:00 PM (EDT)
Event Details
The 5th Annual Clemson Easter Bunny Run 5k and Half Marathon Volunteer Registration & Information
Saturday March 30, 2012
South Carolina Botanical Gardens
Clemson University
150 Discovery Ln
Clemson SC 29634
There is no I in team, but there is a U in Volunteer, and we need you!
Please help us out by volunteering for one or more of the positions listed above. You can sign up for multiple positions as long as the time commitments do not overlap. Information including times of commitment and a description of the position can be found under the "more info" links. We need all the help we can get, but please make sure you know what you are committing to before you register. Thanks! See you in April!
Brief Description of the Event:
Come join us in an exciting morning of fun and fitness. Chase the crazy carrot with your speed enhancing bunny ears as you run the half marathon or 5k. A Crazy Carrot will lead you on a scenic course through Clemson and the surrounding area. If you find an Easter egg along the way, be sure to pick it up for a surprise at the finish. An Easter egg hunt will also take place on the house lawn at the Botanical Gardens for all who wish to participate.
Expect new, fun, and exciting prizes! All half marathon finishers will receive a metal medal for their efforts and participation.
Those running the half marathon will receive the full Clemson running experience. Our course starts off in the South Carolina Botanical Gardens, circles around the Universities campus, adjacent neighborhoods and dikes giving you an excellent opportunity to see our beautiful Lake Hartwell.
The 5k is a rolling course includes the South Carolina Botanical Gardens and tours through part of campus.
*The Half Marathon course features mixed terrain and is NOT wheelchair accessible.
Map of Half Marathon - Always study and know your race course!
Map of 5k
Course Map
The Clemson Triathlon Team and Tigers for Babies will gladly accept any donations. Please make checks payable to Clemson Triathlon Club and/or Tigers for Babies. Event process will help send the active members of the Triathlon Club to Collegiate Nationals and go to the March of Dimes Foundation. GO TIGERS!
6:00am - 7:30am Registration/Check-in
8:00am - Half Marathon Start
8:10am - 5k Start
9:30am - Easter Egg Hunt
9:45am - 5k Awards and Easter Egg Hunt Awards
11:00am - Half Marathon Awards
Sponsors and Volunteers:
For information on becoming a sponsor or volunteer please click here.
Current Sponsors:
Tiger Town Graphics
SC Botanical Gardens
Contact Information & Volunteers Opportunities:
Race Directors: Jefferson Nicholson, 864-247-6735, email@example.com
Kristen Thomas, 803-487-1052, firstname.lastname@example.com
When & Where
South Carolina Botanical Gardens
150 Discovery Ln
Saturday, March 30, 2013 from 1:00 PM to 4:00 PM (EDT)
Add to my calendar


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Northeast CT Farmers Market
Fresh food from local farmers
About Us
Member Farms
Special Events
New Farmer/Vendor Info
Contact Us
Local Farms serving Northeast CT since 1980 with fruit, vegetables, meat, poultry and other farm products.
Welcome to the Northeast Ct Farmers Market website. We hope this helps you learn a little about us. Our farm members grow and produce what they sell, so you know you are getting locally grown, fresh food for you and your family. We hope that you visit us at one (or more) of our markets to enjoy the most fresh fruit, vegetables, meat, cheese and other farm products that you will find anywhere.
2017 Opening Dates
05/04/17 - Putnam - Thursday
05/06/17 - Danielson - Saturday
06/12/17 - Putnam - Monday
06/14/17 - Brooklyn - Wednesday
06/20/17 - Plainfield - Tuesday
Now taking subscriptions for our
Community Supported Agriculture
Subscribe to a weekly share of our farmers' harvest from June to October.
For details click
Vendors needed for the 2017 season!
for more information
Most vendors accept credit and debit cards and we honor Farmers Market Nutrition Program vouchers at all five of our markets.
To receive our
E-mail Newsletter
throughout the season, sign up
Copyright 2017 by Northeast CT Farmers Market Association, Inc.


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| stub.
You can help the Street Fighter Wiki by expanding it.
John Payne (born May 17, 1960) is a British voice actor who voiced Escher in the 1995 animated television series, Street Fighter. He has played several roles in anime shows, most notably Ramba Ral in Mobile Suit Gundam and Rasetsu in InuYasha.


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Watches, Etc.
Men's Rolex
Women's Rolex
Sport Rolex
Other Fine Swiss Watches
Contact Us
Sell Us Your Watch
Stainless Steel Oyster Perpetual 34 (114200)
The minimal, symmetrical look of the Oyster Perpetual models has set them apart from other watches as symbols of universal and classic style. There is nothing quite like the refinement of an original, and that's exactly what we have here with the Oyster Perpetual 34. This latest version of the watch takes the classic proportions of the original Oyster Perpetual and makes them modern with a re-designed 34mm Oyster case, sturdier Oyster band, and their new "White Grape" dial color. This watch is available with its original box and booklets, and our one year warranty.
Manufacture: Rolex
Reference Number: 114200
Band: Stainless Steel Oyster
Dial: "White Grape" with Luminous Hour Index Markers, Royal Blue Accents
Case: 34mm Diameter, Stainless Steel
Bezel: Stainless Steel, Smooth
Crystal: Synthetic Sapphire
Movement: 31 Jewels, Chronometer-Rated, Self-Winding
Similar Watches
Stainless Steel Oyster Perpetual 36 (116000)
Stainless Steel Air-King (114200)
Stainless Steel Air-King (114234)
Stainless Steel Oyster Perpetual 39 (114300)


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1 800 103 2581
Stop following?
Hi! I'm Kartik
I am an engineering graduate in Electronics & Communications...I had 3 backlogs in 3rd semester but I cleared it..after that i had no backlogs at all..My overall aggregate is 59.5%..I have also given GRE and TOEFL.. scores are GRE-305 TOEFL-92.. with these scores and my undergrad aggregate, will I get into any universities? If so, please suggest me some universities based on my profile..Thanks in advance..
- December 12, 2014
- Preferred qualification: Undergraduate | Preferred study destination: United States
Add a quick reply to 'Do backlogs affect my chances of getting an admission into US universites?'
Replies (2)
Dear Kartik,
Greetings from Hotcourses India.
You may consider the following universities options:
University of Cincinnati
Iowa State University
Washington State University
Please send your documents on email@example.com so that we can support you in finalizing some more universities as per your profile and assistance with the further process.
Thanks & Regards,
Hotcourses India
- December 19, 2014
- Flag as inappropriate
- Vote Up (0)
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In our JNTUK system, there is a two subject exception rule, means we can leave two subjects without writing exams or can leave two failed subjects without clearing by the end of engineering. I failed in a subject in my 2nd year electronic devices and didn't need to clear it, so left it. In that case they removed my 1 uncleared backlogs from exempted credits.. So now im taking my GRE coaching & im planning for MS in US. My doubt is that, do we consider that failed subject as a backlog or not? is that Ok for Admission.
- April 27, 2015
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